title: Effect of abiraterone acetate treatment on the quality of life of patients with metastatic castration-resistant prostate cancer after failure of docetaxel chemotherapy.
abstract: BACKGROUND
  In a recent randomised, double-blind, phase III clinical trial among 1195 patients with metastatic castration-resistant prostate cancer (mCRPC) who had failed docetaxel chemotherapy, abiraterone acetate was shown to significantly prolong overall survival compared with prednisone alone. Here we report on the impact of abiraterone therapy on the health-related quality of life (HRQoL) observed during this trial, assessed using the validated Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire.
  
  
  METHODS
  All analyses were conducted using prespecified criteria for clinically meaningful improvement and deterioration in FACT-P total score as well as subscale scores; all respective thresholds were defined using an accepted methodology. Improvement was assessed only in patients with clinically significant functional status impairment at baseline.
  
  
  RESULTS
  Significant improvements in the FACT-P total score were observed in 48% of patients receiving abiraterone versus 32% of patients receiving prednisone (p < 0.0001). Also, the median time to deterioration in FACT-P total score was longer (p < 0.0001) in patients receiving abiraterone (59.9 weeks versus 36.1 weeks). Similar differences were observed in all FACT-P subscales, with the exception of the social/family well-being domain. Median time to improvement in the physical well-being domain and the trial outcome index was significantly shorter (p < 0.01) with abiraterone when compared with the prednisone arm.
  
  
  CONCLUSIONS
  The previously demonstrated survival benefit for abiraterone is accompanied by improvements in patient-reported HRQoL and a significant delay in HRQoL deterioration when compared with prednisone.
authors: UCL Cancer Institute, London, UK. Electronic address: stephen.harland@uclh.nhs.uk.
authors: Stephen
authors: S
authors: Harland
authors: John
authors: J
authors: Staffurth
authors: Arturo
authors: A
authors: Molina
authors: Yanni
authors: Y
authors: Hao
authors: Dennis D
authors: DD
authors: Gagnon
authors: Cora N
authors: CN
authors: Sternberg
authors: David
authors: D
authors: Cella
authors: Karim
authors: K
authors: Fizazi
authors: Christopher J
authors: CJ
authors: Logothetis
authors: Thian
authors: T
authors: Kheoh
authors: Christopher M
authors: CM
authors: Haqq
authors: Johann S
authors: JS
authors: de Bono
authors: Howard I
authors: HI
authors: Scher
mesh_terms: D000069501:Abiraterone Acetate; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D000730:Androstadienes / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009919:Orchiectomy; D010919:Placebos; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D011788:Quality of Life; D011795:Surveys and Questionnaires; D043823:Taxoids / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000730:Androstadienes; D000970:Antineoplastic Agents; D010919:Placebos; D043823:Taxoids; D000077143:Docetaxel; D000069501:Abiraterone Acetate
keywords: Abiraterone; Health; Outcome assessment; Prostate; Quality of life