title: Novel sesquiterpenoid glycosides and sesquiterpenes from the roots of Illicium henryi.
abstract: Seven new sesquiterpenoid glycosides, consisting of one thapsan-type (1), two capnellane-type (2 and 3), four floridanolide sesquiterpene glycosides (4-7), and one new azulene-type sesquiterpene (8), along with six known sesquiterpenes (9-14) were isolated from the roots of Illicium henryi. The structures of 1-8 were elucidated by extensive spectroscopic analyses and chemical methods. The absolute configurations of 1, 2, and 8 were determined based on Rh2(OCOCF3)4-induced CD, Mo2(OAc)4-induced CD data, and calculated electronic circular dichroism (ECD), respectively. Compound 1 was found to exhibit weak neurotoxicant activity.
authors: State Key Laboratory of Bioactive Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors: Peng-Yu
authors: PY
authors: Zhuang
authors: Gui-Jie
authors: GJ
authors: Zhang
authors: Xiao-Jing
authors: XJ
authors: Wang
authors: Yan
authors: Y
authors: Zhang
authors: Shi-Shan
authors: SS
authors: Yu
authors: Shuang-Gang
authors: SG
authors: Ma
authors: Yun-Bao
authors: YB
authors: Liu
authors: Jing
authors: J
authors: Qu
authors: Yong
authors: Y
authors: Li
authors: Nai-Hong
authors: NH
authors: Chen
mesh_terms: D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029523:Illicium / Q000737:chemistry*; D015394:Molecular Structure; D009498:Neurotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D009498:Neurotoxins; D010936:Plant Extracts; D012717:Sesquiterpenes