title: Chlorhexidine or povidone-iodine: Which solution is more effective on skin colonization in neonates?
abstract: BACKGROUND
  Infection control should be an integrated part of patient care, especially to ensure safety and survival in hospitalized neonates. Although povidone-iodine (PVP-I) solution has been used as the most common antiseptic in hospitals of Iran, chlorhexidine is currently used in some wards for skin disinfection. However, there is no evidence about the superiority of either antiseptic solution over the other one. This clinical trial carried out in two university hospitals affiliated to Isfahan University of Medical Sciences, Isfahan, Iran, aimed to compare the effects of chlorhexidine and PVP-I solutions on skin bacterial colonization in hospitalized neonates.
  
  
  METHODS
  The participants were 98 hospitalized infants. In each infant, one area on the skin was disinfected by chlorhexidine while the contralateral site was disinfected by PVP-I. Skin cultures were taken before and after disinfection. Microorganisms were determined and colony count was performed based on a standard method. The collected data were analyzed using descriptive and inferential statistical methods in SPSS v. 14.
  
  
  RESULTS
  The mean of microorganism colony count before and after disinfection by either solution was statistically different (P < 0.001). There was no significant difference between the two groups in terms of mean microorganism colony count before disinfection. However, a significant difference was observed after disinfection.
  
  
  CONCLUSIONS
  PVP-I is more efficacious than chlorhexidine for skin disinfection. Consequently, it seems better to use PVP-I for skin preparation before invasive procedures.
authors: Department of Medical Students Research Committee, Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan, Iran.
authors: Narges
authors: N
authors: Majidipour
authors: Zahra
authors: Z
authors: Abdeyazdan
authors: Ali
authors: A
authors: Zargham-Boroujeni
keywords: Bacterial infection; Iran; chlorhexidine; disinfection; neonate; newborns; povidone-iodine
references: Nurs Stand. 2005 Jul 27-Aug 2;19(46):55-64; quiz 66
references: 16097199
references: Ann Intern Med. 1999 Dec 7;131(11):834-7
references: 10610628
references: Plast Reconstr Surg. 2008 Jan;121(1):115-118
references: 18176213
references: Am J Infect Control. 2003 Jun;31(4):255-6
references: 12806364
references: Can J Ophthalmol. 2010 Dec;45(6):637-41
references: 20935695
references: Pediatr Infect Dis J. 2008 Jun;27(6):505-11
references: 18449064
references: Infect Control Hosp Epidemiol. 2008 Sep;29(9):847-53
references: 18665819
references: J Infect. 2008 May;56(5):354-9
references: 18407355
references: Crit Care. 2010;14(2):212
references: 20236456
references: Pediatr Infect Dis J. 2007 Jun;26(6):492-5
references: 17529865
references: J Perinatol. 2009 Dec;29(12):808-13
references: 19812587
references: Dermatology. 2002;204 Suppl 1:42-6
references: 12011520
references: J Trop Pediatr. 2002 Apr;48(2):123
references: 12022428
references: Pediatrics. 2004 May;113(5):1195-203
references: 15121929
references: N Engl J Med. 2010 Jan 7;362(1):18-26
references: 20054046
references: Pediatr Infect Dis J. 2006 Aug;25(8):665-75
references: 16874163