title: Prevalence of unruptured intracranial aneurysms in healthy asymptomatic Japanese adults: differences in gender and age.
abstract: BACKGROUND
  We aimed to assess the prevalence of unruptured intracranial aneurysms (UIAs) in healthy asymptomatic adults, and investigate the differences in incidence due to gender and age in Japan.
  
  
  METHODS
  Magnetic resonance angiography (MRA) results of healthy asymptomatic adults who underwent the procedure for examination of the brain, from April 2010 to March 2012, were retrospectively examined. Patients with a history of ruptured aneurysm and UIAs were excluded. UIAs greater than 2.0 mm in size were counted. In accordance with these criteria, 8,696 people with a mean age of 52.2±9.5 years were examined, and 37.4 % of these individuals were women.
  
  
  RESULTS
  The overall prevalence of UIAs was 3.2 %. The prevalence in women was higher than that in men (4.4 % versus 2.5 %, OR, 1.81; 95% CI, 1.4 to 2.31). The prevalence increased with age in both genders. In under 49 years, the prevalence in women and men were 2.7 % and 1.9 %, respectively, with no significant differences (OR, 1.47; CI, 0.91 to 2.37). In over 50 years, the prevalence in women was higher than that in men (5.4 % versus 2.8 %, OR, 2.01; CI, 1.52–2.67). There were significant differences in the locations of UIAs by gender (P <0.001); Internal carotid artery was more frequent in women, whereas anterior cerebral artery and middle cerebral artery were more common inmen.
  
  
  CONCLUSIONS
  This study provides etiological data on the prevalence of UIAs in healthy asymptomatic Japanese adults, and may be useful in determining therapeutic managements for UIAs.
authors: Kei
authors: K
authors: Harada
authors: Kouzou
authors: K
authors: Fukuyama
authors: Tetsu
authors: T
authors: Shirouzu
authors: Makoto
authors: M
authors: Ichinose
authors: Haruto
authors: H
authors: Fujimura
authors: Kohsuke
authors: K
authors: Kakumoto
authors: Yoshiyuki
authors: Y
authors: Yamanaga
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D002343:Carotid Artery, Internal / Q000473:pathology; D002533:Cerebral Angiography / Q000379:methods; D002536:Cerebral Arteries / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D007564:Japan; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics