title: Dietary consumption of meat, fat, animal products and advanced glycation end-products and the risk of Barrett's oesophagus.
abstract: BACKGROUND
  Advanced glycation end-products (AGEs) are found in high quantity in high-fat foods and meat cooked at high temperature. AGEs have been shown to contribute to chronic inflammation and oxidative stress in humans.
  
  
  OBJECTIVE
  To investigate the associations between consumption of meat, fat and AGEs, and the risk of Barrett's oesophagus (BO).
  
  
  METHODS
  We conducted a case-control study using data from the patients who were scheduled for elective esophagogastroduodenoscopy (EGD) and from a random sample of patients who were identified at primary care clinics. Daily consumption of meat, fat and Nε-(carboxymethyl) lysine (CML), a major type of AGEs, was derived from the food frequency questionnaire (FFQ). Multivariate logistic regression models were used to estimate the odds ratio (OR) and its 95% confidence interval (CI) for BO.
  
  
  RESULTS
  A total of 151 cases with BO and 777 controls without BO completed the FFQ. The multivariate OR (95% CI) for BO was 1.91 (1.07-3.38) for total meat, 1.80 (1.02-3.16) for saturated fat and 1.63 (0.96-2.76) for CML-AGE, when the highest tertile of intake was compared with the lowest. The association for total meat was attenuated to 1.61 (0.82-3.16), and that for saturated fat to 1.54 (0.81-2.94) after adjusting for CML-AGE.
  
  
  CONCLUSIONS
  Higher consumption of total meat, saturated fat or possibly CML-AGE was associated with an increased risk of Barrett's oesophagus. CML-AGE may partly explain the association between total meat and saturated fat consumption and the risk of Barrett's oesophagus.
authors: Houston VA Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. jiao@bcm.edu
authors: L
authors: L
authors: Jiao
authors: J R
authors: JR
authors: Kramer
authors: L
authors: L
authors: Chen
authors: M
authors: M
authors: Rugge
authors: P
authors: P
authors: Parente
authors: G
authors: G
authors: Verstovsek
authors: A
authors: A
authors: Alsarraj
authors: H B
authors: HB
authors: El-Serag
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects*; D005260:Female; D017127:Glycation End Products, Advanced / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016015:Logistic Models; D008239:Lysine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio
chemical_list: D017127:Glycation End Products, Advanced; C048496:N(6)-carboxymethyllysine; D008239:Lysine
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