title: Association of interleukin-13 SNP rs20541 (Arg>Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.
abstract: In this study, we report our findings as we evaluated the association of IL-13 SNP rs20541 to AR as reported in the meta-analysis (Ying, X-J et al., April, Gene 2013) in an Asian population of 1322 ethnic Chinese recruited in Singapore well defined and characterized for allergic rhinitis. The SNP was significantly associated with AR at an odds ratio of 1.57 for the homozygous genotype comparisons indicating a strong risk for AR. This highlights the importance of this mutation in Asian populations for risk towards allergic phenotypes and also warrants further functional work to characterize the mechanism behind this genetic predisposition.
authors: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors: Anand Kumar
authors: AK
authors: Andiappan
authors: Olaf
authors: O
authors: Rotzschke
authors: De Yun
authors: de Y
authors: Wang
authors: Fook Tim
authors: FT
authors: Chew
mesh_terms: D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
chemical_list: D018793:Interleukin-13
keywords: AR; ARIA 2010; Allergic Rhinitis; Allergic Rhinitis Impact on Asthma 2010; DNA; Deoxyribonucleic Acid; Genetics; IL-13; IgE; Immunoglobulin E; Interleukin-13; SNP; Singapore Chinese; Single Nucleotide Polymorphism; rs20541