title: [Hemophagocytic lymphohistiocytosis associated with a lymphohistiocytic pattern anaplastic large cell lymphoma: a case report].
abstract: We report the case of a 16-year-old girl with an anaplastic large cell lymphoma of lymphohistiocytic pattern revealed by a hemophagocytic syndrome. Histologically, the lymphomatous population was concealed by clusters of histiocytes. Immunohistochemical study allowed the diagnosis. The combination of these two entities is rarely described and may be a source of delay in diagnosis of a life-threatening condition.
authors: Service d'anatomie et de cytologie pathologiques, hôpital de la Source, Orléans cedex 2, France. dsizaret@gmail.com
authors: Damien
authors: D
authors: Sizaret
authors: Claire
authors: C
authors: Lecointre
authors: Rémy
authors: R
authors: Kerdraon
authors: Claire
authors: C
authors: Bléchet
authors: Carole
authors: C
authors: Bonneau
authors: Magda
authors: M
authors: Alexis
authors: François
authors: F
authors: Camus
authors: Patrick
authors: P
authors: Michenet
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics / Q000648:ultrastructure; D005260:Female; D005334:Fever / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008262:Macrophage Activation; D010033:Otitis Media / Q000209:etiology; D010198:Pancytopenia / Q000209:etiology; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D012008:Recurrence; D013163:Splenomegaly / Q000209:etiology; D014178:Translocation, Genetic
chemical_list: D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Anaplastic large cell lymphoma; Hemophagocytic lymphohistiocytosis; Lymphohistiocytic pattern; Lymphome anaplasique à grandes cellules; Syndrome d’activation macrophagique; Variante lymphohistiocytaire