title: [Iron-deficiency anemia].
abstract: Numerous studies have suggested a link between iron-deficiency anemia(IDA) and Helicobacter pylori infection. Previously, we found that strains isolated from IDA patients showed higher levels of Fe ion uptake and Fe-iron-dependent rapid proliferation than those of strains derived from patients without IDA. Recently we examined the nucleotide sequences of nap A, fur, and feo B of H. pylori strains from 24 IDA patients and those from 25 non-IDA patients. Frequency of neutrophil-activating protein A(Nap A), which encoded by nap A, with threonine at amino acid residue No. 70 (Thr70-type Nap A) was significantly higher in IDA strains than non-IDA strains. Strains with Thr70-type Nap A showed significantly higher levels of Fe3+ and Fe2+ uptake than strains with other type, Ser70-type Nap A, which is found in standard strains.
authors: Department of Pediatrics, Sapporo Kosei General Hospital.
authors: Mutsuko
authors: M
authors: Konno
authors: Nariaki
authors: N
authors: Toita
authors: Shin-ichi
authors: S
authors: Yokota
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D060740:Disease Eradication / Q000379:methods; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D016480:Helicobacter pylori; D006801:Humans; D007501:Iron / Q000378:metabolism*
chemical_list: D007501:Iron