title: Trypanosoma evansi infection impairs memory, increases anxiety behaviour and alters neurochemical parameters in rats.
abstract: The aim of this study was to investigate neurochemical and enzymatic changes in rats infected with Trypanosoma evansi, and their interference in the cognitive parameters. Behavioural assessment (assessment of cognitive performance), evaluation of cerebral L-[3H]glutamate uptake, acetylcholinesterase (AChE) activity and Ca+2 and Na+, K+-ATPase activity were evaluated at 5 and 30 days post infection (dpi). This study demonstrates a cognitive impairment in rats infected with T. evansi. At 5 dpi memory deficit was demonstrated by an inhibitory avoidance test. With the chronicity of the disease (30 dpi) animals showed anxiety symptoms. It is possible the inhibition of cerebral Na+, K+-ATPase activity, AChE and synaptosomal glutamate uptake are involved in cognitive impairment in infected rats by T. evansi. The understanding of cerebral host–parasite relationship may shed some light on the cryptic symptoms of animals and possibly human infection where patients often present with other central nervous system (CNS) disorders.
authors: Department of Chemistry, Universidade Federal de Santa Maria, Brazil. patiwol@hotmail.com
authors: Patrícia
authors: P
authors: Wolkmer
authors: Francine C
authors: FC
authors: Paim
authors: Cássia B
authors: CB
authors: DA Silva
authors: Bibiana M
authors: BM
authors: Gai
authors: Fabiano B
authors: FB
authors: Carvalho
authors: Ana Cristina G
authors: AC
authors: DA Souza
authors: Michelle M
authors: MM
authors: DA Rosa
authors: Aleksandro S
authors: AS
authors: DA Silva
authors: Paula R
authors: PR
authors: Pereira
authors: Sonia T A
authors: ST
authors: Lopes
authors: Cristina W
authors: CW
authors: Nogueira
authors: Maribel A
authors: MA
authors: Rubin
authors: Silvia G
authors: SG
authors: Monteiro
authors: Cinthia M
authors: CM
authors: Mazzanti
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000469:parasitology*; D001259:Ataxia; D001522:Behavior, Animal; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003072:Cognition Disorders; D004285:Dogs; D018698:Glutamic Acid / Q000032:analysis; D006790:Host-Parasite Interactions; D006801:Humans; D008297:Male; D018782:Maze Learning; D009420:Nervous System / Q000737:chemistry; D018512:Parasitemia; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014316:Tritium / Q000032:analysis; D014345:Trypanosoma / Q000502:physiology*; D014352:Trypanosomiasis / Q000469:parasitology / Q000503:physiopathology*
chemical_list: D014316:Tritium; D018698:Glutamic Acid; D000110:Acetylcholinesterase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase