title: Impact of cow's milk allergy on enterocolitis associated with Hirschsprung's disease.
abstract: OBJECTIVE
  To investigate the impact of cow's milk allergy (CMA) on infants with Hirschsprung's disease (HD).
  
  
  METHODS
  Twenty-four patients, who developed gastrointestinal symptoms before the age of 60 days and underwent surgery for HD in the period between January 2003 and December 2012, were enrolled in this study. They were divided into two groups based on CMA-related findings: stimulation index of lymphocyte stimulation test >300 % and the presence of eosinophilic infiltration in the resected colon. Ten patients were determined specimen as not having CMA (Group A), because they did not satisfy any of the criteria. The remaining 14 were determined as having possible CMA (Group B), because they satisfied either or both findings. Patient background characteristics, pre- and postoperative clinical history, and laboratory data were compared between Groups A and B.
  
  
  RESULTS
  Pre- and postoperative enterocolitis did not occur in Group A patients. Postoperative enterocolitis was more frequent in Group B than in Group A (p = 0.04). Other clinical and laboratory data did not show significant difference between the two groups.
  
  
  CONCLUSIONS
  CMA is a possible risk factor for postoperative enterocolitis in patients with HD.
authors: Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho Izumi, Osaka, 594-1101, Japan, s_umeda3104@yahoo.co.jp.
authors: Satoshi
authors: S
authors: Umeda
authors: Hisayoshi
authors: H
authors: Kawahara
authors: Akihiro
authors: A
authors: Yoneda
authors: Yuko
authors: Y
authors: Tazuke
authors: Gakuto
authors: G
authors: Tani
authors: Tomohiro
authors: T
authors: Ishii
authors: Taro
authors: T
authors: Goda
authors: Katsuhisa
authors: K
authors: Hirano
authors: Kayo
authors: K
authors: Ikeda
authors: Shinobu
authors: S
authors: Ida
authors: Masahiro
authors: M
authors: Nakayama
authors: Akio
authors: A
authors: Kubota
authors: Masahiro
authors: M
authors: Fukuzawa
mesh_terms: D000818:Animals; D013505:Digestive System Surgical Procedures; D004760:Enterocolitis / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006627:Hirschsprung Disease / Q000150:complications* / Q000276:immunology / Q000601:surgery; D006801:Humans; D007111:Immunity, Cellular; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008892:Milk / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D015995:Prevalence; D012189:Retrospective Studies
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