title: Tissue interactions in neural crest cell development and disease.
abstract: The neural crest is a transient population of migratory cells in the embryo that gives rise to a wide variety of different cell types, including those of the peripheral nervous system. Dysfunction of neural crest cells (NCCs) is associated with multiple diseases, such as neuroblastoma and Hirschsprung disease. Recent studies have identified NCC behaviors during their migration and differentiation, with implications for their contributions to development and disease. Here, we describe how interactions between cells of the neural crest and lineages such as the vascular system, as well as those involving environmental signals and microbial pathogens, are critically important in determining the roles played by these cells.
authors: Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. yotayota@develop.zool.kyoto-u.ac.jp
authors: Yoshiko
authors: Y
authors: Takahashi
authors: Douglas
authors: D
authors: Sipp
authors: Hideki
authors: H
authors: Enomoto
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology / Q000196:embryology; D002450:Cell Communication; D019070:Cell Lineage; D002465:Cell Movement; D002642:Chick Embryo; D002648:Child; D006627:Hirschsprung Disease / Q000473:pathology; D006801:Humans; D007422:Intestines / Q000166:cytology* / Q000294:innervation*; D039902:Multipotent Stem Cells / Q000502:physiology*; D009432:Neural Crest / Q000166:cytology*; D009447:Neuroblastoma / Q000473:pathology; D009473:Neuronal Plasticity; D010275:Parasympathetic Nervous System / Q000166:cytology*; D012583:Schwann Cells / Q000473:pathology / Q000502:physiology; D013564:Sympathetic Nervous System / Q000166:cytology*