title: TMPRSS2 is an activating protease for respiratory parainfluenza viruses.
abstract: Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.
authors: Department of Virology 3.
authors: Masako
authors: M
authors: Abe
authors: Maino
authors: M
authors: Tahara
authors: Kouji
authors: K
authors: Sakai
authors: Hiromi
authors: H
authors: Yamaguchi
authors: Kazuhiko
authors: K
authors: Kanou
authors: Kazuya
authors: K
authors: Shirato
authors: Miyuki
authors: M
authors: Kawase
authors: Masahiro
authors: M
authors: Noda
authors: Hirokazu
authors: H
authors: Kimura
authors: Shutoku
authors: S
authors: Matsuyama
authors: Hideo
authors: H
authors: Fukuhara
authors: Katsumi
authors: K
authors: Mizuta
authors: Katsumi
authors: K
authors: Maenaka
authors: Yasushi
authors: Y
authors: Ami
authors: Mariko
authors: M
authors: Esumi
authors: Atsushi
authors: A
authors: Kato
authors: Makoto
authors: M
authors: Takeda
mesh_terms: D000818:Animals; D002460:Cell Line; D004847:Epithelial Cells / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D018098:Paramyxovirinae / Q000502:physiology*; D012697:Serine Endopeptidases / Q000378:metabolism*; D019562:Viral Load; D010948:Viral Plaque Assay; D014779:Virus Replication
chemical_list: D012697:Serine Endopeptidases
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