title: Low complement levels in paediatric systemic lupus erythematosus and the risk of bacteraemia.
abstract: This report describes an 11-year-old girl with systemic lupus erythematosus (SLE) with long-standing low levels of complement proteins. A disease period with lupus nephritis (class IIIa) was complicated by Staphylococcus aureus bacteraemia and osteomyelitis. She was treated with high-dose immunosuppressants and 6 weeks of high-dose intravenous antibiotics. The clinician should be aware of bacteraemia in SLE with secondary complement deficiency.
authors: Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands.
authors: Jaap P
authors: JP
authors: Hagen
authors: Petra C E Hissink
authors: PC
authors: Muller
authors: Robbert G M
authors: RG
authors: Bredius
authors: Rebecca
authors: R
authors: ten Cate
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy* / Q000276:immunology; D002648:Child; D003165:Complement System Proteins / Q000172:deficiency* / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology*; D008181:Lupus Nephritis / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D003165:Complement System Proteins
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