title: Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease.
abstract: Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1.
authors: FAMERP, São José do Rio Preto SP, Brasil. marcelapinhel@yahoo.com.br
authors: Marcela Augusta de Souza
authors: MA
authors: Pinhel
authors: Caroline Leiko
authors: CL
authors: Sado
authors: Gabriela Dos Santos
authors: Gdos S
authors: Longo
authors: Michele Lima
authors: ML
authors: Gregório
authors: Gisele Sousa
authors: GS
authors: Amorim
authors: Greiciane Maria da Silva
authors: GM
authors: Florim
authors: Camila Montoro
authors: CM
authors: Mazeti
authors: Denise Poltronieri
authors: DP
authors: Martins
authors: Fábio de Nazaré
authors: Fde N
authors: Oliveira
authors: Marcelo Arruda
authors: MA
authors: Nakazone
authors: Waldir Antonio
authors: WA
authors: Tognola
authors: Dorotéia Rossi Silva
authors: DR
authors: Souza
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics; D010575:Pesticides / Q000633:toxicity*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase; D010575:Pesticides; C413545:glutathione S-transferase T1