title: Zinc and myocardial ischemia/reperfusion injury.
abstract: As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.
authors: Department of Physiology & Pathophysiology, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, People's Republic of China, zxu@tijmu.edu.cn.
authors: Zhelong
authors: Z
authors: Xu
authors: Juan
authors: J
authors: Zhou
mesh_terms: D001692:Biological Transport; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D008668:Metallothionein / Q000235:genetics / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015032:Zinc / Q000378:metabolism*
chemical_list: D027682:Cation Transport Proteins; D008668:Metallothionein; D011494:Protein Kinases; D015032:Zinc