title: State-of-the-art dried blood spot analysis: an overview of recent advances and future trends.
abstract: Dried blood spots have become a popular method in a variety of micro blood-sampling techniques in the life sciences sector, consequently competing with the field of conventional, invasive blood sampling by venepuncture. Dried blood spots are widely applied in numerous bioanalytical assays and have gained a significant role in the screening of inherited metabolic diseases, in PK and PD modeling; in the treatment and diagnosis of infectious diseases; and in therapeutic drug monitoring. Recent technological developments such as automation, online extraction, mass spectrometric direct analysis and also conventional dried blood spot bioanalysis, as well as future developments in dried blood spot bioanalysis are highlighted and presented in this article.
authors: Universidad de los Andes, Faculty of Sciences, Department of Chemistry, Cra. 1 No. 18A-10, Q-building, Room 826, Bogota D.C., Colombia. rj.meesters@uniandes.edu.co
authors: Roland Jw
authors: RJ
authors: Meesters
authors: Gero P
authors: GP
authors: Hooff
mesh_terms: D001800:Blood Specimen Collection / Q000379:methods; D002853:Chromatography, Liquid; D003141:Communicable Diseases / Q000097:blood*; D059788:Dried Blood Spot Testing / Q000706:statistics & numerical data / Q000639:trends*; D016903:Drug Monitoring; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000097:blood*; D046210:Microfluidic Analytical Techniques; D055553:Prescription Drugs / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D052617:Solid Phase Microextraction; D012997:Solvents; D053719:Tandem Mass Spectrometry
chemical_list: D055553:Prescription Drugs; D012997:Solvents