title: Extensive deep dermatophytosis cause by Trichophyton rubrum in a patient with liver cirrhosis and chronic renal failure.
abstract: Dermatophytes are the main pathogen of superficial skin fungal infections. On rare occasions, they can cause deep and extensive infections, especially in immunocompromised hosts. We reported a 48-year-old patient with liver cirrhosis and chronic renal failure who developed an extensive deep dermatophytosis with possible hematogenous dissemination. Skin histopathology showed extensive involvement of hair follicles and dermis by fungal elements. The pathogen was cultured from both skin biopsy specimen and central venous line. It was identified as Trichophyton rubrum by morphology and further conformed by sequencing of internal transcribed spacers of ribosomal DNA. The patient died quickly before the identification was available.
authors: Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors: Lung-Chi
authors: LC
authors: Wu
authors: Pei-Lun
authors: PL
authors: Sun
authors: Yun-Ting
authors: YT
authors: Chang
mesh_terms: D001706:Biopsy; D017809:Fatal Outcome; D006651:Histocytochemistry; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008103:Liver Cirrhosis / Q000150:complications*; D008828:Microbiological Techniques; D008875:Middle Aged; D017422:Sequence Analysis, DNA; D012867:Skin / Q000382:microbiology / Q000473:pathology; D014005:Tinea / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D014249:Trichophyton / Q000302:isolation & purification*
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