title: Surface modification of biomaterials for conjugation with human fetal osteoblasts.
abstract: Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
authors: Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne.
authors: Françoise
authors: F
authors: Borcard
authors: Phally
authors: P
authors: Kong
authors: Céline
authors: C
authors: Journot
authors: Davide
authors: D
authors: Staedler
authors: Philip N
authors: PN
authors: Sturzenegger
authors: Franziska Krauss
authors: FK
authors: Juillerat
authors: Urs T
authors: UT
authors: Gonzenbach
authors: Lucienne
authors: L
authors: Juillerat-Jeanneret
authors: Sandrine
authors: S
authors: Gerber-Lemaire
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry* / Q000378:metabolism; D057930:Click Chemistry; D017886:Durapatite / Q000737:chemistry* / Q000378:metabolism; D005333:Fetus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite