title: Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males.
abstract: Postprandial insulin release is lower in healthy aerobically trained (T) compared to untrained (UT) individuals. This may be mediated by a lower release of the two incretin hormones [glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)] in T. The aim of this study was to assess and compare gut hormone response and satiety changes after a liquid meal intake in young, healthy T and UT males. Postprandial gut hormone release and subjective feelings of hunger, satiety, fullness and prospective food consumption were assessed before and frequently for the following 3 h after a 200 ml liquid meal (1,260 kJ and 27, 41 and 32 energy % as protein, carbohydrates and fat, respectively) in ten T and ten UT young, healthy male subjects. The insulin and GIP responses were markedly lower in T than UT and correlated during the first 30 min after the liquid meal. Baseline GLP-1 concentration was higher in T versus UT, but the response in the following 3 h after a liquid meal was similar in T and UT. Satiety measures did not differ between groups throughout the test. It is possible that in aerobically T subjects, a lower GIP release is partly responsible for a lower postprandial incretin stimulated insulin secretion.
authors: Department of Biomedical Sciences, Center for Healthy Aging, Xlab, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark, michaeltl@sund.ku.dk.
authors: Michael Taulo
authors: MT
authors: Lund
authors: Lærke
authors: L
authors: Taudorf
authors: Bolette
authors: B
authors: Hartmann
authors: Jørn Wulff
authors: JW
authors: Helge
authors: Jens Juel
authors: JJ
authors: Holst
authors: Flemming
authors: F
authors: Dela
mesh_terms: D000328:Adult; D004435:Eating; D015444:Exercise; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D006801:Humans; D054795:Incretins / Q000097:blood*; D007328:Insulin / Q000097:blood; D008297:Male; D062407:Meals / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D012527:Satiation; D057185:Sedentary Behavior
chemical_list: D054795:Incretins; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide
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