title: Association of polymorphisms in natural killer cell-related genes with preterm birth.
abstract: Inflammation is implicated in preterm birth, but genetic studies of inflammatory genes have yielded inconsistent results. Maternal DNA from 1,646 participants in the Pregnancy, Infection, and Nutrition Cohort, enrolled in Orange and Wake counties, North Carolina (1995-2005), were genotyped for 432 tag single-nucleotide polymorphisms (SNPs) in 30 candidate genes. Gene-level and SNP associations were modeled within strata of genetic ancestry. Six genes were associated with preterm birth among European Americans: interleukin 12A (IL12A); colony-stimulating factor 2 (CSF2); interferon γ receptor 2 (IFNGR2); killer cell immunoglobulin-like receptor, three domain, long cytoplasmic tail, 2 (KIR3DL2); interleukin 4 (IL4); and interleukin 13 (IL13). Of these, relatively strong single-SNP associations were seen in IFNGR2 and KIR3DL2. Among the 4 genes related to natural killer cell function, 2 (IL12A and CSF2) were consistently associated with reduced risk of prematurity for both European and African Americans. SNPs tagging a locus control region for IL4 and IL13 were associated with an increased risk of spontaneous preterm birth for European Americans (rs3091307; risk ratio = 1.9; 95% confidence interval: 1.4, 2.5). Although gene-level associations were detected only in European Americans, single-SNP associations among European and African Americans were often similar in direction, though estimated with less precision among African Americans. In conclusion, we identified novel associations between variants in the natural killer cell immune pathway and prematurity in this biracial US population.
authors: Quaker E
authors: QE
authors: Harmon
authors: Stephanie M
authors: SM
authors: Engel
authors: Andrew F
authors: AF
authors: Olshan
authors: Thomas
authors: T
authors: Moran
authors: Alison M
authors: AM
authors: Stuebe
authors: Jingchun
authors: J
authors: Luo
authors: Michael C
authors: MC
authors: Wu
authors: Christy L
authors: CL
authors: Avery
mesh_terms: D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D003115:Colony-Stimulating Factors / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D060005:Genotyping Techniques; D006801:Humans; D007378:Interleukins / Q000235:genetics; D007694:Killer Cells, Natural / Q000502:physiology; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000208:ethnology / Q000235:genetics*; D017471:Receptors, Interferon / Q000235:genetics; D054347:Receptors, KIR3DL2 / Q000235:genetics; D013601:T-Lymphocytes; D044465:White People / Q000235:genetics
chemical_list: D003115:Colony-Stimulating Factors; C086185:IFNGR2 protein, human; D007378:Interleukins; C515084:KIR3DL2 protein, human; D017471:Receptors, Interferon; D054347:Receptors, KIR3DL2
keywords: African Americans; European Continental Ancestry Group; genetics; genetic association studies; inflammation; natural killer cells; premature birth
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