title: Rubrolide R: a new furanone metabolite from the ascidian Synoicum of the Indian Ocean.
abstract: A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of < 1 μM.
authors: a College of Pharmaceutical Sciences, Andhra University , Visakhapatnam , 530003 , Andhra Pradesh India.
authors: Desaraju
authors: D
authors: Smitha
authors: Muthyala Murali Krishna
authors: MM
authors: Kumar
authors: Hechhu
authors: H
authors: Ramana
authors: Desaraju Venkata
authors: DV
authors: Rao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004664:Encephalitis Virus, Japanese / Q000187:drug effects; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019156:Indian Ocean; D015394:Molecular Structure; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D005663:Furans; C000588804:rubrolide R