title: R292K substitution and drug susceptibility of influenza A(H7N9) viruses.
abstract: Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
authors: Katrina
authors: K
authors: Sleeman
authors: Zhu
authors: Z
authors: Guo
authors: John
authors: J
authors: Barnes
authors: Michael
authors: M
authors: Shaw
authors: James
authors: J
authors: Stevens
authors: Larisa V
authors: LV
authors: Gubareva
mesh_terms: D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D024882:Drug Resistance, Viral / Q000235:genetics*; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000187:drug effects* / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008826:Microbial Sensitivity Tests; D009439:Neuraminidase / Q000235:genetics* / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D009439:Neuraminidase
keywords: H7N9; R292K; antimicrobial resistance; antiviral resistance; avian influenza; influenza; neuraminidase inhibitor; oseltamivir; recombinant neuraminidase; viruses; zanamivir
references: N Engl J Med. 2013 May 16;368(20):1888-97
references: 23577628
references: Antiviral Res. 2002 May;54(2):99-111
references: 12062395
references: Influenza Other Respir Viruses. 2013 Sep;7(5):645-58
references: 23575174
references: J Virol. 1997 May;71(5):3385-90
references: 9094607
references: Antiviral Res. 2002 May;54(2):79-88
references: 12062393
references: Lancet. 2013 Jun 29;381(9885):2273-9
references: 23726392
references: Antiviral Res. 2009 Jan;81(1):16-24
references: 18835410
references: Antiviral Res. 2000 Jul;47(1):1-17
references: 10930642
references: Antivir Ther. 2012;17(1 Pt B):159-73
references: 22311680
references: MMWR Morb Mortal Wkly Rep. 2013 May 10;62(18):366-71
references: 23657113
references: J Virol. 1998 Mar;72(3):2456-62
references: 9499107
references: Wkly Epidemiol Rec. 2012 Sep 28;87(39):369-74
references: 23061103
references: J Virol. 2010 Sep;84(18):9427-38
references: 20631138