title: [Expression and regulation of the SOST gene].
abstract: Sclerostin(SOST), mainly expressed in osteocytes, is a negative regulator of bone formation. Hormones PTH and E2 inhibit the expression of the SOST gene. Transcription factors Osterix, Runx2, and Mef2c promote the SOST expression, while Sirt1 negatively regulates the SOST expression. In addition, the expression of the SOST gene is regulated by epigenetic mechanisms, such as DNA methylation and microRNA. Mutations in the SOST gene, which cause sclerosteosis and Van Buchem diseases, are associated with osteoporosis. Wnt and BMP are two important signaling pathways in bone metabolic regulation. SOST can regulate osteoblastic differentiation and bone formation by binding type I/II receptors and co-receptor LRP5/6 to inhibit BMP and Wnt signaling pathways. Suppression of SOST provides a new approach for osteoporosis treatment. This review covers the structure, function and expression regulation of the SOST gene, human disease association, mechanism in the regulation of bone metabolism and prospect in clinical application.
authors: College of Life Science, Central China Normal University, Wuhan 430079, China E-mail: qlj0125@126.com.
authors: Long-Juan
authors: LJ
authors: Qin
authors: Da-Xia
authors: DX
authors: Ding
authors: Lu-Lu
authors: LL
authors: Cui
authors: Qing-Yang
authors: QY
authors: Huang
mesh_terms: D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones; D005819:Genetic Markers; D006801:Humans; D010011:Osteocytes; D060449:Wnt Signaling Pathway
chemical_list: D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers