title: Design, synthesis, and application of stimulus-sensing biohybrid hydrogels.
abstract: A key feature of any living system is the ability to sense and react to the environmental stimuli. The biochemical characterization of the underlying biological sensors combined with advances in polymer chemistry has enabled the development of stimulus-sensitive biohybrid materials that translate most diverse chemical and biological input into a precise change in material properties. In this review article, we first describe synthesis strategies of how biological and chemical polymers can functionally be interconnected. We then provide a comprehensive overview of how the different properties of biological sensor molecules such as competitive target binding and allosteric modulation can be harnessed to develop responsive materials with applications in tissue engineering and drug delivery.
authors: Faculty of Biology, BIOSS - Centre for Biological Signalling Studies, SGBM - Spemann Graduate School of Biology and Medicine, University of Freiburg, Schänzlestrasse 18, 79104, Freiburg, Germany; Faculty of Biology, University of Freiburg, Schänzlestrasse 18, 79104, Freiburg, Germany.
authors: Natascha
authors: N
authors: Hotz
authors: Louisa
authors: L
authors: Wilcke
authors: Wilfried
authors: W
authors: Weber
mesh_terms: D000937:Antigen-Antibody Reactions; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D020100:Hydrogels; D010455:Peptides; D011108:Polymers; D011506:Proteins; D004247:DNA
keywords: biohybrid; conjugation; drug delivery systems; hydrogels; stimulus responsive