title: Eyelash growth induced by topical prostaglandin analogues, bimatoprost, tafluprost, travoprost, and latanoprost in rabbits.
abstract: OBJECTIVE
  Prostaglandin analogues (PGA) are ocular hypotensive agents used for the treatment of glaucoma. Hypertrichosis of the eyelashes has been reported in humans as a side effect. Eyelash growth was investigated with clinical trials in people using bimatoprost. Scattered reports of eyelash growth during the treatment of glaucoma with other PGA are also found in the literature. We investigated the effect of 4 different topical PGA on eyelash length.
  
  
  METHODS
  Forty New Zealand white rabbits were divided into 4 groups and received daily topical application of bimatoprost, tafluprost, travoprost, and latanoprost in the left eye for 4 weeks. The right eye received no treatment. Eyelash length was measured in both eyes before and after treatment using a stainless steel digital caliper.
  
  
  RESULTS
  Bimatoprost and tafluprost groups had significant increases in eyelash length. We did not observe significant eyelash growth in rabbits receiving travoprost and latanoprost after 1 month of treatment.
  
  
  CONCLUSIONS
  Today, only bimatoprost is approved for growing eyelashes, and our research shows that tafluprost could be further explored by the cosmetic and pharmaceutical industry. Additional research using travoprost and latanoprost as agents for eyelash growth should be performed in the future using prolonged treatment periods to determine whether or not these PGA induce eyelash growth, and investigate other possible side effects.
authors: 1 Department of Veterinary Medicine, Federal University of Paraná , Curitiba, Brazil .
authors: Amália Turner
authors: AT
authors: Giannico
authors: Leandro
authors: L
authors: Lima
authors: Heloisa Helena Abil
authors: HH
authors: Russ
authors: Fabiano
authors: F
authors: Montiani-Ferreira
mesh_terms: D000287:Administration, Topical; D000577:Amides / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000069580:Bimatoprost; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D005140:Eyelashes / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006983:Hypertrichosis / Q000139:chemically induced*; D000077338:Latanoprost; D008297:Male; D011460:Prostaglandins F / Q000008:administration & dosage / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D000069557:Travoprost
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; C485333:tafluprost; D003008:Cloprostenol; D000077338:Latanoprost; D000069580:Bimatoprost; D000069557:Travoprost