title: Impact of pubertal development on endothelial function and arterial elasticity.
abstract: OBJECTIVE
  Little is known about the relation of pubertal development on endothelial function and arterial elasticity in children and adolescents; therefore, we compared brachial artery flow-mediated dilation and carotid artery elasticity across Tanner (pubertal) stages in children and adolescents.
  
  
  METHODS
  Blood pressure, fasting lipids, glucose and insulin, body fat, insulin sensitivity adjusted for lean body mass, brachial flow-mediated dilation (percent dilation and area under the curve), endothelium-independent dilation (peak dilation and area under the curve), and carotid artery elasticity were evaluated across pubertal stages (Tanner I vs Tanner II-IV vs Tanner V) in 344 children and adolescents (184 males, 160 females; ages 6 to 21 years).
  
  
  RESULTS
  One hundred twenty-four subjects (mean age 8.23 ± 0.15 years; 52 females) were Tanner stage I; 105 subjects (mean age 13.19 ± 0.17 years; 47 females) were Tanner stages II-IV; and 115 subjects (mean age 17.19 ± 0.16 years; 61 females) were Tanner stage V. There were no significant differences for any of the measures of vascular structure and function across pubertal stages.
  
  
  CONCLUSIONS
  Results of the current study indicate that smooth-muscle and endothelial function, as well as carotid artery elasticity, do not differ throughout pubertal development and that accounting for pubertal stage when reporting vascular data in children and adolescents may be unnecessary.
authors: Laboratory of Integrative Human Physiology, School of Kinesiology, University of Minnesota, Minneapolis, MN.
authors: Kara L
authors: KL
authors: Marlatt
authors: Julia
authors: J
authors: Steinberger
authors: Donald R
authors: DR
authors: Dengel
authors: Alan
authors: A
authors: Sinaiko
authors: Antoinette
authors: A
authors: Moran
authors: Lisa S
authors: LS
authors: Chow
authors: Lyn M
authors: LM
authors: Steffen
authors: Xia
authors: X
authors: Zhou
authors: Aaron S
authors: AS
authors: Kelly
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D019540:Area Under Curve; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology*; D017536:Carotid Artery, Common / Q000502:physiology*; D002648:Child; D003430:Cross-Sectional Studies; D004548:Elasticity; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D011627:Puberty; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids
keywords: AUC; Area under the curve; BMI; Body mass index; DBP; Diastolic blood pressure; EID; Endothelium-independent dilation; FMD; Flow-mediated dilation; IRB; Institutional Review Board; NTG; Nitroglycerin; SBP; Systolic blood pressure
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