title: Bioconjugation by native chemical tagging of C-H bonds.
abstract: A general C-H functionalization method for the tagging of natural products and pharmaceuticals is described. An azide-containing sulfinate reagent allows the appendage of azidoalkyl chains onto heteroaromatics, the product of which can then be attached to a monoclonal antibody by a "click" reaction. This strategy expands the breadth of bioactive small molecules that can be linked to macromolecules in a manner that is beyond the scope of existing methods in bioconjugation to permit tagging of the "seemingly untaggable".
authors: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors: Qianghui
authors: Q
authors: Zhou
authors: Jinghan
authors: J
authors: Gui
authors: Chung-Mao
authors: CM
authors: Pan
authors: Earl
authors: E
authors: Albone
authors: Xin
authors: X
authors: Cheng
authors: Edward M
authors: EM
authors: Suh
authors: Luigi
authors: L
authors: Grasso
authors: Yoshihiro
authors: Y
authors: Ishihara
authors: Phil S
authors: PS
authors: Baran
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D057930:Click Chemistry; D015394:Molecular Structure; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D001386:Azides; D001688:Biological Products; D013441:Sulfinic Acids
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