title: Effects of repeated 5-HT₆ receptor stimulation on BDNF gene expression and cell survival.
abstract: In support of the neurotrophic hypothesis of depression chronic antidepressant drug treatment increases brain-derived neurotrophic factor (bdnf) gene expression and neurogenesis. Regarding 5-HT active drugs, the 5-HT receptor behind these effects remains unidentified. Here we report the effect of repeated 5-HT₆-receptor stimulation on bdnf expression and cell survival. The previously reported acute stimulatory action of the selective 5-HT₆ agonist LY-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. The effect on 5-HT₆-mediated cell survival was also dependent on a similar length of treatment. Hence, our study found no support for a primary effect of 5-HT₆ receptors in the mediation of chronic antidepressant drug-induced up-regulation of bdnf expression or neurogenesis.
authors: Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
authors: Georgina
authors: G
authors: de Foubert
authors: Ahmad A
authors: AA
authors: Khundakar
authors: Tyra S
authors: TS
authors: Zetterström
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D002470:Cell Survival; D008297:Male; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C097216:serotonin 6 receptor
keywords: 5-HT(6) receptors; Antidepressant drugs; BDNF; Brain derived neurotrophic factor; Neurogenesis; Serotonin