title: Illustration of anti-rheumatic mechanism of rheumavedic capsule.
abstract: The present study was taken up to illustrate the mechanism of anti-rheumatic activity of 'Rheumavedic capsule', a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced paw edema in rats. Analgesic mechanism is illustrated using Eddy's hot plate and acetic acid (0.6%v/v) induced writhing in mice. Histopathology of knee joint was studied. Rheumavedic showed inhibition of inflammation mediated through Histamine, 5-Hydroxy tryptamine, and Bradykinin. Rheumavedic showed protection in both acetic acid and Eddy's hot plate induced pain. Histopathology of knee joint of rat pre-treated with rheumavedic showed significant reduction in the mononuclear infiltration, pannus formation and adhesion molecules. The anti-rheumatic mechanism of rheumavedic is due to; inhibition of inflammatory mediators i.e., Histamine, 5-Hydroxy tryptamine and Bradykinin., protection against prostaglandins mediated pain, by inhibiting cyclo-oxygenase synthesis and reduction in pannus formation, by inhibiting mononuclear infiltration.
authors: Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, 22nd main, 24th cross, Banashankari IInd Stage, Bangalore, Karnataka 560 070, India.
authors: Sumanth
authors: S
authors: Meera
authors: Nandeep
authors: N
authors: Ramaiah
authors: Narasimharaju
authors: N
authors: Kalidindi
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