title: [Venous thromboembolism in adolescents associated with fourth-generation oral contraceptives].
abstract: Venous thromboembolism (VTE) is a rare, but feared adverse drug reaction of combined oral contraceptives. Modern oral contraceptives contain novel progestins, which are suspected of causing thrombotic events more frequently than well-known progestins. Drospirenone is one of those new fourth-generation progestins with antiandrogenic and antimineralocorticoid effects. Especially girls and young women do not only wish for contraception, but also for positive effects on skin and body weight. In the last decade, however, the safety of this progestin was often under discussion.A detailed literature search was conducted to obtain an overview of currently available data on the risk of VTE among girls and young women using drospirenone-containing contraceptives. It appears that drospirenone-containing contraceptives have a similar increase in risk as third-generation oral contraceptives and antiandrogens. Compared to second-generation contraceptives containing the progestin levonorgestrel there is an approximate 2-fold risk increase (1.0 to 2.8-fold) in women aged 10-55 years. Accurate data regarding the risk in the age group under 18 years are lacking. Nevertheless, the risk of VTE appears to be higher in young -women during the first months of treatment. Until more data for nov-el progestins are available and the safety profile is well defined well-studied second-generation oral contraceptives with low dose estrogen and better risk-benefit ratio should be preferred in young women. In any case, all patients should be comprehensively informed regarding the benefits and risks of each contraceptive method.
authors: Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Germany.
authors: S
authors: S
authors: Botzenhardt
authors: I
authors: I
authors: Toni
authors: W
authors: W
authors: Rascher
authors: A
authors: A
authors: Neubert
mesh_terms: D000293:Adolescent; D000736:Androstenes / Q000009:adverse effects*; D002648:Child; D003430:Cross-Sectional Studies; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D012102:Reproductive Control Agents / Q000008:administration & dosage / Q000009:adverse effects*; D012306:Risk; D054556:Venous Thromboembolism / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000736:Androstenes; D012102:Reproductive Control Agents; C534342:drospirenone and ethinyl estradiol combination; D004997:Ethinyl Estradiol