title: Narrowband ultraviolet B irradiation increases the serum level of vitamin D₃ in patients with neurofibromatosis 1.
abstract: The serum vitamin D₃ levels in patients with neurofibromatosis 1 has been reported to be significantly lower than that in control subjects, and the level of vitamin D₃ reversely correlates with the severity of neurofibroma formation. We found that narrowband ultraviolet B (NB-UVB) irradiation increased the serum level of 1,25(OH)₂ vitamin D₃ in patients with neurofibromatosis 1. The difference in the 1,25(OH)₂ vitamin D₃ levels between patients who had received irradiation for more than 18 months and those who had no irradiation was highly significant. Time-course analyses of the serum vitamin D₃ levels in the patients who were enrolled after informed consent revealed that the levels became higher significantly after 6 months of irradiation. It is suggested that NB-UVB irradiation is effective for increasing the serum level of vitamin D₃ in patients with neurofibromatosis 1, which may be of benefit for skin symptoms such as pigmented macules or neurofibromas.
authors: Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
authors: Juichiro
authors: J
authors: Nakayama
authors: Shinichi
authors: S
authors: Imafuku
authors: Tatsuki
authors: T
authors: Mori
authors: Chiemi
authors: C
authors: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002762:Cholecalciferol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000097:blood / Q000532:radiotherapy*; D014467:Ultraviolet Therapy; D055815:Young Adult
chemical_list: D002762:Cholecalciferol
keywords: 1,25(OH)2 vitamin D3; café-au-lait spots; itching; narrowband ultraviolet B; neurofibromatosis 1