title: Improved anticoagulation of titanium by sequential immobilization of oligo(ethylene glycol) and 2-methacryloyloxyethyl phosphorylcholine.
abstract: Titanium and its alloys have been widely used for blood-contacting biomedical devices; however, their blood compatibility needs to be improved. In this study, titanium surface was modified by sequential immobilization of oligo(ethylene glycol) (OEG) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to improve its anticoagulation. Water contact angle results showed an excellent hydrophilic surface after the immobilization. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) confirmed that OEG and MPC were successfully immobilized on titanium surface. Static platelet adhesion and APTT (activated partial thromboplastin time) experiments suggested that the anticoagulation of titanium was significantly enhanced by the immobilization of OEG and further by subsequent MPC grafting. The approach in the present study opens up a window of promising an effective and efficient method to improve the anticoagulation of blood-contact biomedical devices such as coronary stents.
authors: Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, China. Electronic address: swjtupcj@163.com.
authors: Chang-Jiang
authors: CJ
authors: Pan
authors: Yan-Hua
authors: YH
authors: Hou
authors: Heng-Quan
authors: HQ
authors: Liu
authors: Hong-Yan
authors: HY
authors: Ding
authors: Yun-Xiao
authors: YX
authors: Dong
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D054855:Drug-Eluting Stents; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry*; D010314:Partial Thromboplastin Time; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; C070638:2-methacryloyloxyethyl phosphorylcholine; D014025:Titanium
keywords: Anticoagulation; MPC; Oligo(ethylene glycol); Surface modification; Titanium