title: Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis.
abstract: The corrole-based catalytic antioxidant reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. and a non-redox active analogue of it affect the committed step of the biosynthetic pathway--the HMG-CoA reductase catalysed reaction--by acting as allosteric inhibitors of this key enzyme.
authors: Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel. chr10zg@tx.technion.ac.il.
authors: Adi
authors: A
authors: Haber
authors: Amona
authors: A
authors: Abu-Younis Ali
authors: Michael
authors: M
authors: Aviram
authors: Zeev
authors: Z
authors: Gross
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D002460:Cell Line; D002784:Cholesterol / Q000096:biosynthesis; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000378:metabolism; D000077340:Fluvastatin; D006903:Hydroxymethylglutaryl CoA Reductases / Q000737:chemistry / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000201:enzymology; D008665:Metalloporphyrins / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
chemical_list: D000975:Antioxidants; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D008665:Metalloporphyrins; D000077340:Fluvastatin; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases