title: New structure of phage-related islands carrying fusB and a virulence gene in fusidic acid-resistant Staphylococcus epidermidis.
abstract: Nucleotide sequencing of the fusB-flanking regions in two fusidic acid-resistant Staphylococcus epidermidis isolates with the type IV aj1-leader peptide (LP)-fusB structure (lacking aj1) revealed that their fusB gene was located on novel phage-related islands inserted downstream of smpB and are here referred to as SeRIfusB-3692 and SePIfusB-857. The novel SePIfusB-857 structure was followed by SeCI857, forming a composite pathogenicity island which contained a putative virulence gene, vapE. The linkage of fusB and vapE may contribute to bacterial adaption.
authors: Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
authors: Hsiao-Jan
authors: HJ
authors: Chen
authors: Ya-Chun
authors: YC
authors: Chang
authors: Jui-Chang
authors: JC
authors: Tsai
authors: Wei-Chun
authors: WC
authors: Hung
authors: Yu-Tzu
authors: YT
authors: Lin
authors: Shang-Jie
authors: SJ
authors: You
authors: Sung-Pin
authors: SP
authors: Tseng
authors: Lee-Jene
authors: LJ
authors: Teng
mesh_terms: D000222:Adaptation, Physiological; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D005672:Fusidic Acid / Q000494:pharmacology; D015964:Gene Expression Regulation, Bacterial; D044404:Genomic Islands; D008826:Microbial Sensitivity Tests; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D013204:Staphylococcus Phages / Q000235:genetics* / Q000378:metabolism; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity*; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D016601:RNA-Binding Proteins; D037521:Virulence Factors; C430328:small protein B; D005672:Fusidic Acid
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