title: Efficient synthesis of boron-containing α-acyloxyamide analogs via microwave irradiation.
abstract: In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
authors: Department of Chemistry, Tamkang University, New Taipei 25137, Taiwan.
authors: Chih-Cheng
authors: CC
authors: Chai
authors: Pin-Yi
authors: PY
authors: Liu
authors: Chia-Hung
authors: CH
authors: Lin
authors: Hsien-Chi
authors: HC
authors: Chen
authors: Yang-Chang
authors: YC
authors: Wu
authors: Fang-Rong
authors: FR
authors: Chang
authors: Po-Shen
authors: PS
authors: Pan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001895:Boron / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D008872:Microwaves
chemical_list: D000970:Antineoplastic Agents; D001895:Boron
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