title: Regulation of histone gene transcription in yeast.
abstract: Histones are the primary protein component of chromatin, the mixture of DNA and proteins that packages the genetic material in eukaryotes. Large amounts of histones are required during the S phase of the cell cycle when genome replication occurs. However, ectopic expression of histones during other cell cycle phases is toxic; thus, histone expression is restricted to the S phase and is tightly regulated at multiple levels, including transcriptional, post-transcriptional, translational, and post-translational. In this review, we discuss mechanisms of regulation of histone gene expression with emphasis on the transcriptional regulation of the replication-dependent histone genes in the model yeast Saccharomyces cerevisiae.
authors: The Donnelly Center, University of Toronto, Toronto, ON, M5S 3E1, Canada.
authors: Christoph F
authors: CF
authors: Kurat
authors: Judith
authors: J
authors: Recht
authors: Ernest
authors: E
authors: Radovani
authors: Tanja
authors: T
authors: Durbic
authors: Brenda
authors: B
authors: Andrews
authors: Jeffrey
authors: J
authors: Fillingham
mesh_terms: D015966:Gene Expression Regulation, Fungal; D006657:Histones / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015533:Transcriptional Activation
chemical_list: D006657:Histones; D029701:Saccharomyces cerevisiae Proteins
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