title: Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin).
abstract: Prolactin elevations occur in people treated with antipsychotic medications and are often much higher in women than in men. Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gynecomastia in females and is also associated with sexual dysfunction and bone loss. These side effects increase risk of antipsychotic nonadherence and suicide and pose significant problems in the long term management of women with schizophrenia. In this manuscript, we review the literature on prolactin; its physiology, plasma levels, side effects and strategies for treatment. We also present the rationale and protocol for an ongoing clinical trial to treat symptomatic hyperprolactinemia in premenopausal women with schizophrenia. More attention and focus are needed to address these significant side effects and help the field better personalize the treatment of women with schizophrenia.
authors: School of Medicine, Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, Maryland, USA. dkelly@mprc.umaryland.edu.
authors: Deanna L
authors: DL
authors: Kelly
authors: Heidi J
authors: HJ
authors: Wehring
authors: Amber K
authors: AK
authors: Earl
authors: Kelli M
authors: KM
authors: Sullivan
authors: Faith B
authors: FB
authors: Dickerson
authors: Stephanie
authors: S
authors: Feldman
authors: Robert P
authors: RP
authors: McMahon
authors: Robert W
authors: RW
authors: Buchanan
authors: Dale
authors: D
authors: Warfel
authors: William R
authors: WR
authors: Keller
authors: Bernard A
authors: BA
authors: Fischer
authors: Joo-Cheol
authors: JC
authors: Shim
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000068180:Aripiprazole; D002985:Clinical Protocols; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D012107:Research Design; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole
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