title: Mucoadhesive buccal patches based on interpolymer complexes of chitosan-pectin for delivery of carvedilol.
abstract: The study was designed to develop bioadhesive patches of carvedilol hydrochloride using chitosan (CH) and pectin (PE) interpolymer complexes and to systematically evaluate their in vitro and in vivo performances. Mucoadhesive buccal patches of carvedilol were prepared using solvent casting method. The physicochemical interaction between CH and PE was investigated by FTIR and DSC studies. The patches were evaluated for their physical characteristics like mass variation, content uniformity, folding endurance, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, surface pH, in vitro drug release, in situ release study, and in vivo bioavailability study. The swelling index of the patches was found to be proportional to the PE concentration. The surface pH of all the formulated bioadhesive patches was found to lie between 6.2 and 7.2. The optimized bioadhesive patch (C1, CH:PE 20:80) showed bioadhesive strength of 22.10 ± 0.20 g, in vitro release of 98.73% and ex vivo mucoadhesion time of 451 min with in a period of 8 h. The optimized patch demonstrated good in vitro and in vivo results. The buccal delivery of carvedilol in rabbits showed a significant improvement in bioavailability of carvedilol from patches when compared to oral route.
authors: Rayat and Bahra Institute of Pharmacy, Sahauran, Mohali, Punjab, India.
authors: Amanpreet
authors: A
authors: Kaur
authors: Gurpreet
authors: G
authors: Kaur
keywords: Bioadhesion; Buccal patch; Carvedilol hydrochloride; Chitosan; Pectin
references: Fertil Steril. 2008 Nov;90(5):1864-8
references: 18462734
references: Drug Dev Ind Pharm. 2004;30(9):995-1004
references: 15554224
references: AAPS PharmSciTech. 2010 Mar;11(1):36-45
references: 20017011
references: J Control Release. 2009 Oct 15;139(2):94-107
references: 19559740
references: Curr Drug Deliv. 2007 Jan;4(1):27-39
references: 17269915
references: Crit Rev Ther Drug Carrier Syst. 1988;5(1):21-67
references: 3293807
references: AAPS PharmSciTech. 2004 Apr 29;5(3):e35
references: 15760069
references: Colloids Surf B Biointerfaces. 2009 Nov 1;74(1):103-13
references: 19643587
references: J Pharm Sci. 1996 May;85(5):457-60
references: 8742934
references: Colloids Surf B Biointerfaces. 2010 Jun 1;77(2):227-33
references: 20188529
references: J Pharm Pharmacol. 1991 Jul;43(7):457-64
references: 1682457
references: Eur J Pharm Sci. 1998 Jul;6(3):207-17
references: 9795062
references: Eur J Pharm Biopharm. 2004 Jan;57(1):19-34
references: 14729078
references: Arzneimittelforschung. 1999 Sep;49(9):745-9
references: 10514901
references: Drug Dev Ind Pharm. 1999 Jun;25(6):701-9
references: 10349555
references: J Pharm Sci. 2000 Jul;89(7):850-66
references: 10861586
references: Oral Dis. 2006 Jul;12(4):420-3
references: 16792729
references: Acta Pharm. 2007 Mar;57(1):61-72
references: 19839407
references: Drug Dev Ind Pharm. 2004 Jul;30(6):609-17
references: 15285334
references: J Photochem Photobiol B. 2010 Oct 5;101(1):59-69
references: 20634088
references: Clin Pharmacokinet. 1994 May;26(5):335-46
references: 7914479