title: Non-coding RNAs and cancer.
abstract: The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.
authors: Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. federica.calore@osumc.edu
authors: Federica
authors: F
authors: Calore
authors: Francesca
authors: F
authors: Lovat
authors: Michela
authors: M
authors: Garofalo
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D022661:RNA, Untranslated / Q000502:physiology*
chemical_list: D022661:RNA, Untranslated
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