title: Early parenteral lipids and growth velocity in extremely-low-birth-weight infants.
abstract: OBJECTIVE
  Whether early parenteral lipids improve postnatal growth of preterm neonates remains unclear. We aimed to assess the effects of parenteral lipids on growth velocity in extremely-low-birth-weight infants.
  
  
  METHODS
  This retrospective cohort study included 121 extremely-low-birth-weight infants. The associations between parenteral lipids (cumulative intakes during the first week and delays in their introduction) and growth velocities (weight, head circumference and length) up to 28 days of life and to 36 weeks of corrected age were analysed using uni- and multivariate linear regression.
  
  
  RESULTS
  Univariate analyses showed a significant positive association between the cumulative intakes of parenteral lipids during the first week and i) weight gain up to day 28; ii) weight gain up to 36 weeks of corrected age; iii) head circumference growth up to day 28. There was a negative correlation between the delay in parenteral lipid introduction and weight gain up to day 28. In multivariate analyses, the association between the cumulative intakes of parenteral lipids and weight gain up to 28 days was independent of gestational age at birth, birth weight, sex, smallness for gestational age, and enteral intakes (regression coefficient: 0.19; 95% CI: 0.01-0.38) and, up to 36 weeks, independent of gestational age, birth weight, sex, smallness for gestational age and parenteral glucose and amino acids (0.16; 95% CI: 0.04-0.27).
  
  
  CONCLUSIONS
  Parenteral lipids during the first week were positively associated with weight gain in extremely-low-birth-weight infants and could improve early nutritional support of preterm neonates.
authors: Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfants, Hospices Civils de Lyon, Bron, France; Service de Néonatologie, Département Médico-Chirurgical de Pédiatrie, Centre Hospitalier Universitaire Vaudois et Université de Lausanne, Switzerland.
authors: Céline Julie
authors: CJ
authors: Fischer
authors: Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique Santé, Pierre-Bénite, France; Université Claude-Bernard, Lyon, France.
authors: Delphine
authors: D
authors: Maucort-Boulch
authors: Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfants, Hospices Civils de Lyon, Bron, France.
authors: Christine Murielle
authors: CM
authors: Essomo Megnier-Mbo
authors: Service de Biostatistique, Hospices Civils de Lyon, Lyon, France; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique Santé, Pierre-Bénite, France; Université Claude-Bernard, Lyon, France.
authors: Laurent
authors: L
authors: Remontet
authors: Service de Réanimation Néonatale et Néonatologie, Hôpital Femme Mère Enfants, Hospices Civils de Lyon, Bron, France; Equipe d'Accueil Mixte EAM 4128, Lyon, France. Electronic address: olivier.claris@chu-lyon.fr.
authors: Olivier
authors: O
authors: Claris
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D001724:Birth Weight; D002149:Energy Intake; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D007363:Intensive Care Units, Neonatal; D016014:Linear Models; D008055:Lipids / Q000008:administration & dosage* / Q000032:analysis; D008297:Male; D015999:Multivariate Analysis; D010288:Parenteral Nutrition / Q000379:methods*; D012189:Retrospective Studies; D015430:Weight Gain
chemical_list: D000596:Amino Acids; D008055:Lipids; D005947:Glucose
keywords: Extremely low birth weight infant; Growth; Lipids; Newborn; Parenteral nutrition; Preterm infant