title: Obstetric management does not influence vertical transmission of HCV infection: results of the ALHICE group study.
abstract: OBJECTIVE
  To investigate the impact of variation in obstetric practice during labor and childbirth upon the rate of neonatal transmission of HCV.
  
  
  METHODS
  Pregnant mothers were included in this prospective study from six hospitals in Southern France on the basis of positive HCV serology. Data recorded for the study included maternal factors, delivery details and laboratory data concerning mother and child. Pediatric follow-up was documented for a minimum of 1 year and for up to 2 years for children with circulating HCV RNA.
  
  
  RESULTS
  Two hundred and fourteen mother-child pairs were investigated. HIV/HCV co-infected mothers had a rate of HCV transmission significantly higher (11%) than that observed for mono-infected mothers (3.8%) (odds ratio=3.08 [95% CI:0.95 to 9.99] p=0.05). When the HCV viral load was greater than or equal to 6 log copies/ml, the transmission rate was 14.3% [95% CI:5.4-28.5], this representing a risk of transmission four times higher than for women with a lower viral load (OR=4 [95% CI:1.3-12.4]). Among co-infected mothers, the risk of transmission was significantly increased even when the load was less than 6 log copies/ml (p=0.006). Risk factors were identified related to labor (duration and induction type); the birth process (rupture of the amniotic sac, complete opening of the sac, appearance of the amniotic fluid); fetal characteristics (prematurity) and obstetric maneuvers (instrumental extractions, spontaneous or induced perineal trauma) and none of these factors were associated with an increased rate of HCV maternal-fetal transmission.
  
  
  CONCLUSIONS
  HCV infection does not appear to be a legitimate indication for modifying obstetric practices with regards to type of induction, monitoring of labor, route of delivery, fetal and perineal obstetric maneuvers or care of the newborn in the delivery room.
authors: Department of Obstetrics, Gynecology, Reproduction and Fetal Medicine .
authors: Jérôme
authors: J
authors: Delotte
authors: Eugènia Mariné
authors: EM
authors: Barjoan
authors: Alain
authors: A
authors: Berrébi
authors: Catherine
authors: C
authors: Laffont
authors: Paul
authors: P
authors: Benos
authors: Christian
authors: C
authors: Pradier
authors: André
authors: A
authors: Bongain
mesh_terms: D000328:Adult; D060085:Coinfection; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006526:Hepatitis C / Q000150:complications / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011446:Prospective Studies