title: The detection of oral pre- malignant lesions with an autofluorescence based imaging system (VELscope™) - a single blinded clinical evaluation.
abstract: OBJECTIVE
  The disease specific five-year survival rate especially for patients with advanced oral cancer has not improved significantly over the period of time. The most effective way of combating this dilemma is an early detection, diagnosis and eradication of early-stage lesions and their precursors. The use of VELscope® using an autofluorescence as a diagnostic tool might be useful in early detection of oral malignant lesions.
  
  
  METHODS
  120 patients with suspicious oral premalignant lesions were examined with two examination methods. They were randomly divided into two groups. Group 1 was examined conventional with white-light and group 2 was examined additionally to the white-light-examination with an autofluorescence visualization device, VELscope®. Biopsies were obtained from all suspicious areas identified in both examination groups (n = 52). The diagnostic strategies were compared regarding sensitivity and specificity.
  
  
  RESULTS
  Based upon the result, use of the VELscope® leads to a higher sensitivity (22.0%), but regarding specificity the additional use of the VELscope® is inferior (8.4%).
  
  
  CONCLUSIONS
  The VELscope device is a simple, non-invasive test of the oral mucosa, which can help the experienced clinician to find oral precursor malignant lesions.
authors: Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. r.smeets@uke.de.
authors: Henning
authors: H
authors: Hanken
authors: Juliane
authors: J
authors: Kraatz
authors: Ralf
authors: R
authors: Smeets
authors: Max
authors: M
authors: Heiland
authors: Alexandre Thomas
authors: AT
authors: Assaf
authors: Marco
authors: M
authors: Blessmann
authors: Wolfgang
authors: W
authors: Eichhorn
authors: Till Sebastian
authors: TS
authors: Clauditz
authors: Alexander
authors: A
authors: Gröbe
authors: Andreas
authors: A
authors: Kolk
authors: Madiha
authors: M
authors: Rana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D055088:Early Detection of Cancer / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging / Q000295:instrumentation*; D011230:Precancerous Conditions / Q000175:diagnosis*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method
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