title: Effect of an 18-month physical activity and weight loss intervention on body composition in overweight and obese older adults.
abstract: OBJECTIVE
  Our primary objective was to determine the long-term effects of physical activity (PA) and weight loss (WL) on body composition in overweight/obese older adults. Secondarily, the association between change in body mass and composition on change in several cardiometabolic risk factors and mobility was evaluated.
  
  
  METHODS
  288 older (X ± SD: 67.0 ± 4.8 years), overweight/obese (BMI 32.8 ± 3.8 kg/m² ) men and women participated in this 18-month randomized, controlled trial. Treatment groups included PA + WL (n = 98), PA-only (n = 97), and a successful aging (SA) health education control (n = 93). DXA-acquired body composition measures (total body fat and lean mass), conventional biomarkers of cardiometabolic risk, and 400-m walk time were obtained at baseline and 18 months.
  
  
  RESULTS
  Fat mass was significantly reduced from (X ± SE) 36.5 ± 8.9 kg to 31.7 ± 9.0 kg in the PA + WL group (p < 0.01), but remained unchanged from baseline in the PA-only (-0.8 ± 3.8 kg) and SA (-0.0 ± 3.9 kg) group. Lean mass losses were three times greater in the PA + WL groups compared to PA-only or SA groups (-2.5 ± 2.8 kg vs. -0.7 ± 2.2 kg or -0.8 ± 2.4 kg, respectively; p < 0.01); yet due to a larger decrease in fat mass, percent lean mass was significantly increased over baseline in the PA + WL groups (2.1% ± 2.6%; p < 0.01). Fat mass loss was primarily responsible for WL-associated improvements in cardiometabolic risk factors, while reduction in body weight, regardless of compartment, was significantly associated with improved mobility.
  
  
  CONCLUSIONS
  This 18-month PA + WL program resulted in a significant reduction in percent body fat with a concomitant increase in percent body lean mass. Shifts in body weight and composition were associated with favorable changes in clinical parameters of cardiometabolic risk and mobility. Moderate PA without WL had no effect on body composition.
authors: Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
authors: Kristen M
authors: KM
authors: Beavers
authors: Daniel P
authors: DP
authors: Beavers
authors: Beverly A
authors: BA
authors: Nesbit
authors: Walter T
authors: WT
authors: Ambrosius
authors: Anthony P
authors: AP
authors: Marsh
authors: Barbara J
authors: BJ
authors: Nicklas
authors: W Jack
authors: WJ
authors: Rejeski
mesh_terms: D050154:Adiposity; D000368:Aged; D000375:Aging; D001521:Behavior Therapy; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D004038:Diet, Reducing; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009069:Movement Disorders / Q000453:epidemiology / Q000517:prevention & control; D024510:Muscle Development; D009657:North Carolina / Q000453:epidemiology; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology / Q000628:therapy*; D050177:Overweight / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology / Q000628:therapy*; D012307:Risk Factors; D016138:Walking; D015431:Weight Loss
chemical_list: D015415:Biomarkers
references: J Nutr Health Aging. 2013 Jan;17(1):3-7
references: 23299370
references: Med Sci Sports Exerc. 2008 Jul;40(7):1213-9
references: 18580399
references: Obesity (Silver Spring). 2006 May;14(5):737-52
references: 16855180
references: J Gerontol A Biol Sci Med Sci. 2007 Aug;62(8):866-71
references: 17702878
references: Obes Res. 2005 Nov;13(11):1849-63
references: 16339115
references: J Am Diet Assoc. 2009 Nov;109(11):1886-95
references: 19857630
references: Clin Physiol. 1994 Jul;14(4):433-42
references: 7955941
references: J Am Geriatr Soc. 2004 Jul;52(7):1105-13
references: 15209648
references: Circulation. 2001 Feb 20;103(7):947-53
references: 11181468
references: J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):691-8
references: 23183902
references: J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):80-6
references: 22503993
references: Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10
references: 15173056
references: Med Sci Sports Exerc. 2009 Feb;41(2):459-71
references: 19127177
references: Arch Intern Med. 2006 Apr 24;166(8):860-6
references: 16636211
references: Obesity (Silver Spring). 2011 Aug;19(8):1636-46
references: 21233810
references: J Obes. 2011;2011:
references: 20953373
references: J Gerontol A Biol Sci Med Sci. 2005 Mar;60(3):324-33
references: 15860469
references: J Appl Physiol (1985). 2012 Jan;112(1):79-85
references: 22016371
references: J Am Geriatr Soc. 2001 Nov;49(11):1544-8
references: 11890597
references: Am J Med. 1999 May;106(5):506-12
references: 10335721
references: Am J Clin Nutr. 2006 Dec;84(6):1317-23
references: 17158411
references: Am J Clin Nutr. 2011 Sep;94(3):767-74
references: 21795437
references: J Gerontol A Biol Sci Med Sci. 2009 May;64(5):575-80
references: 19276190
references: Arthritis Rheum. 2004 May;50(5):1501-10
references: 15146420
references: Int J Obes (Lond). 2007 May;31(5):743-50
references: 17075583
references: JAMA. 2012 Feb 1;307(5):491-7
references: 22253363
references: N Engl J Med. 2011 Mar 31;364(13):1218-29
references: 21449785
references: Am J Clin Nutr. 2013 Mar;97(3):552-60
references: 23364001
references: Arch Intern Med. 2011 May 23;171(10):880-6
references: 21263080
references: Arch Intern Med. 2000 Apr 10;160(7):898-904
references: 10761953
references: Obesity (Silver Spring). 2009 Dec;17(12):2162-8
references: 19390517
references: Exp Gerontol. 2013 Oct;48(10):1054-61
references: 23403042
references: Am J Prev Med. 2004 Dec;27(5):385-90
references: 15556738
references: J Am Geriatr Soc. 2013 Jul;61(7):1089-94
references: 23772804
references: J Appl Physiol (1985). 2008 Aug;105(2):473-8
references: 18535122
references: Am J Clin Nutr. 2000 Apr;71(4):885-92
references: 10731493
references: J Nutr Health Aging. 2008 Aug-Sep;12(7):487-91
references: 18615231