title: Disadvantages of VKA and requirements for novel anticoagulants.
abstract: Vitamin K antagonists have been in wide use for over 70 years. Warfarin, the most commonly used vitamin K antagonist, has been shown to be highly effective in treating and preventing thrombosis. Despite this, warfarin has many disadvantages, which has led to the development of a new class of oral anticoagulants targeted to specific coagulation factors designated as target-specific oral anticoagulants (TSOAs). TSOAs include the thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban, apixaban). This chapter reviews the disadvantages of warfarin and evaluates both the advantages and disadvantages of the new oral anticoagulants.
authors: Department of Internal Medicine, Lenox Hill Hospital, New York, NY 10075, USA. rshameem@nshs.edu
authors: Raji
authors: R
authors: Shameem
authors: Jack
authors: J
authors: Ansell
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000069604:Dabigatran; D054796:Drug Dosage Calculations; D004347:Drug Interactions; D065427:Factor Xa Inhibitors; D006801:Humans; D009025:Morpholines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011728:Pyridones / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D000069552:Rivaroxaban; D013876:Thiophenes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013917:Thrombin / Q000037:antagonists & inhibitors; D013927:Thrombosis / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000009:adverse effects* / Q000493:pharmacokinetics; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D065427:Factor Xa Inhibitors; D009025:Morpholines; D011720:Pyrazoles; D011728:Pyridones; D013876:Thiophenes; D015091:beta-Alanine; D014812:Vitamin K; C522181:apixaban; D014859:Warfarin; D000069552:Rivaroxaban; D013917:Thrombin; D000069604:Dabigatran
keywords: apixaban; dabigatran; oral anticoagulation; rivaroxaban; vitamin K antagonists; warfarin