title: Size matching in lung transplantation: an evidence-based review.
abstract: The evidence base for size matching between donors and recipients in lung transplantation has not recently been reviewed in a comprehensive manner. Our aim in this study was to assimilate published studies that have addressed size matching of donors to recipients and to establish a pragmatic understanding of the range of lung sizes that may be used for lung transplantation. A comprehensive literature search was performed using Medline and PubMed up to and including September 2012, to identify scientific articles that relate to size matching between donors and lung transplant recipients. Seventy-two articles were identified, of which 21 had addressed the question of the impact of size mismatching on outcomes in lung transplantation. No study has specifically tested the consequences of intentionally mismatching above or below the hypothetical limits for double lung transplantation of a predicted total lung capacity for the donor of between 75% and 125% of the recipient predicted total lung capacity as set out in the ISHLT consensus report on lung donor acceptability criteria. Research is lacking that has robustly defined limits for size mismatch for single lung transplantation and for recipients with restrictive lung pathologies such as pulmonary fibrosis. Published research on the impact of size mismatching between lung transplant donors and recipients is limited by study design and size. It is centered on addressing the issue of mismatch in double lung transplantation in cohorts with a diagnostically heterogeneous make-up and in single lung transplant patients with chronic obstructive pulmonary disease.
authors: Department of Cardiothoracic Transplantation, Papworth Hospital, Papworth Everard, Cambridge, Cambridgeshire CB2 3RE, UK. jamesbbarnard@doctors.org.uk
authors: James B
authors: JB
authors: Barnard
authors: Owain
authors: O
authors: Davies
authors: Philip
authors: P
authors: Curry
authors: Pedro
authors: P
authors: Catarino
authors: John
authors: J
authors: Dunning
authors: David
authors: D
authors: Jenkins
authors: Catherine
authors: C
authors: Sudarshan
authors: Sukumaran
authors: S
authors: Nair
authors: Steven
authors: S
authors: Tsui
authors: Jasvir
authors: J
authors: Parmar
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D016040:Lung Transplantation / Q000379:methods / Q000639:trends*; D008176:Lung Volume Measurements; D009929:Organ Size; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery; D014019:Tissue Donors; D014109:Total Lung Capacity / Q000502:physiology; D014180:Transplantation; D016896:Treatment Outcome
keywords: evidence; lung transplantation; outcome; review; sizing