title: Palladium-catalyzed alkyne insertion/reduction route to trisubstituted olefins.
abstract: A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.
authors: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
authors: Erin R
authors: ER
authors: Fruchey
authors: Brendan M
authors: BM
authors: Monks
authors: Andrea M
authors: AM
authors: Patterson
authors: Silas P
authors: SP
authors: Cook