title: Electroacupuncture and rosiglitazone combined therapy as a means of treating insulin resistance and type 2 diabetes mellitus: a randomized controlled trial.
abstract: Aims. To evaluate the efficacy of rosiglitazone (TZD) and electroacupuncture (EA) combined therapy as a treatment for type 2 diabetes mellitus (T2DM) patients by randomized single-blind placebo controlled clinical trial. Methods. A total of 31 newly diagnostic T2DM patients, who fulfilled the study's eligibility criteria, were recruited. The individuals were randomly assigned into two groups, the control group (TZD, N = 15) and the experimental group (TZD + EA, N = 16). Changes in their plasma free fatty acid (FFA), glucose, and insulin levels, together with their homeostasis model assessment (HOMA) indices, were statistically compared before and after treatment. Hypoglycemic activity (%) was also compared between these two groups. Results. There was no significant difference in hypoglycemic activity between the TZD and TZD + EA group. The effectiveness of the combined therapy seems to derive from an improvement in insulin resistance and a significant lowering of the secreted insulin rather than the effect of TZD alone on T2DM. The combined treatment had no significant adverse effects. A lower plasma FFA concentration is likely to be the mechanism that causes this effect. Conclusion. This combined therapy seems to suppress endogenous insulin secretion by improving insulin resistance via a mechanism involving a reduction in plasma FFA. This trial is registered with ClinicalTrials.gov NCT01577095.
authors: Department of Internal Medicine and Emergency Medicine, Division of Endocrinology and Metabolism, Tungs' Taichung Metro Harbor Hospital, Taichung County, Taiwan.
authors: Rong-Tsung
authors: RT
authors: Lin
authors: Huei-Chin
authors: HC
authors: Pai
authors: Yu-Chen
authors: YC
authors: Lee
authors: Chung-Yuh
authors: CY
authors: Tzeng
authors: Chin-Hsien
authors: CH
authors: Chang
authors: Pei-Hsiu
authors: PH
authors: Hung
authors: Ying-I
authors: YI
authors: Chen
authors: Tai-Hao
authors: TH
authors: Hsu
authors: Chin-Chun
authors: CC
authors: Tsai
authors: Jaung-Geng
authors: JG
authors: Lin
authors: Shih-Liang
authors: SL
authors: Chang
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