title: Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models.
abstract: Cancer-associated cachexia is characterized, among other symptoms, by a dramatic loss of both muscle and fat. In addition, the cachectic syndrome is often associated with anemia. The object of the present investigation was to assess the effects of erythropoietin (EPO) treatment on experimental cancer cachexia models. The results clearly show that, in addition to the improvement of the hematocrit, EPO treatment promoted a partial preservation of adipose tissue while exerting negligible effects on muscle loss. Administration of EPO to tumor-bearing animals resulted in a significant increase of lipoprotein lipase (LPL) activity in adipose tissue, suggesting that the treatment favored triacylglycerol (TAG) accumulation in the adipose tissue. In vitro experiments using both adipose tissue slices and 3T3-L1 adipocytes suggests that EPO is able to increase the lipogenic rate through the activation of its specific receptor (EPOR). This metabolic pathway, in addition to TAG uptake by LPL, may contribute to the beneficial effects of EPO on fat preservation in cancer cachexia.
authors: Departament de Bioquímica i Biologia Molecular and Institut de Biomedicina (IBUB).
authors: Fabio
authors: F
authors: Penna
authors: Silvia
authors: S
authors: Busquets
authors: Miriam
authors: M
authors: Toledo
authors: Fabrizio
authors: F
authors: Pin
authors: David
authors: D
authors: Massa
authors: Francisco J
authors: FJ
authors: López-Soriano
authors: Paola
authors: P
authors: Costelli
authors: Josep M
authors: JM
authors: Argilés
mesh_terms: D041721:3T3-L1 Cells; D000273:Adipose Tissue / Q000187:drug effects* / Q000473:pathology*; D000818:Animals; D002100:Cachexia / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004921:Erythropoietin / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D009369:Neoplasms / Q000150:complications*; D051381:Rats; D017467:Receptors, Erythropoietin / Q000378:metabolism
chemical_list: D017467:Receptors, Erythropoietin; D004921:Erythropoietin
keywords: anemia; lipogenesis; lipolysis; lipoprotein lipase
references: Am J Med. 2004 Apr 5;116 Suppl 7A:11S-26S
references: 15050883
references: Blood. 2010 May 27;115(21):4254-63
references: 20124514
references: Eur J Haematol. 2007 Mar;78(3):183-205
references: 17253966
references: Curr Opin Support Palliat Care. 2011 Dec;5(4):356-60
references: 21934502
references: PLoS One. 2010 Oct 27;5(10):e13604
references: 21048967
references: Cancer Lett. 1997 Jun 24;116(2):159-65
references: 9215859
references: J Orthop Res. 2008 Dec;26(12):1618-26
references: 18634017
references: Med Hypotheses. 2008;70(6):1167-73
references: 18180110
references: Biochem Z. 1959;332:18-46
references: 14402528
references: Cancer. 2004 May 1;100(9):1967-77
references: 15112279
references: CA Cancer J Clin. 2007 Jul-Aug;57(4):225-41
references: 17626119
references: Cancer. 2003 Sep 1;98(5):1072-9
references: 12942577
references: Kidney Int Suppl. 1999 Jul;71:S213-5
references: 10412779
references: Am J Physiol. 1997 Apr;272(4 Pt 1):E656-60
references: 9142888
references: Lancet Oncol. 2000 Nov;1:138-47
references: 11905651
references: Eur J Cancer. 2006 Jan;42(1):31-41
references: 16314085
references: PLoS One. 2010 Nov 15;5(11):e13986
references: 21085572
references: Nucleic Acids Res. 1991 Jul 25;19(14):3843-8
references: 1650452
references: Mol Cell Biochem. 1995 Feb 23;143(2):113-8
references: 7596346
references: J Biol Chem. 2000 Dec 15;275(50):39754-61
references: 10995753
references: Clin Cancer Res. 2004 Oct 15;10(20):6855-64
references: 15501962
references: Cancer. 2001 Jun 15;91(12):2214-21
references: 11413508
references: Clin Nutr. 2010 Apr;29(2):154-9
references: 20060626
references: Cancer Res. 1975 Apr;35(4):939-45
references: 1116151
references: J Lipid Res. 1976 Sep;17(5):536-41
references: 9464
references: Biochem J. 1985 Nov 15;232(1):229-36
references: 4084231
references: Arch Biochem Biophys. 1993 Oct;306(1):52-8
references: 8215420
references: Cancer. 2005 May 15;103(10):2189-98
references: 15822132
references: Science. 2011 Jul 8;333(6039):233-8
references: 21680814
references: J Biol Chem. 1951 Nov;193(1):265-75
references: 14907713