title: Studies on anticancer activities of lactoferrin and lactoferricin.
abstract: This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.
authors: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, HONG KONG. b021770@mailserv.cuhk.edu.hk.
authors: Cui Ming
authors: CM
authors: Yin
authors: Jack Ho
authors: JH
authors: Wong
authors: Jiang
authors: J
authors: Xia
authors: Tzi Bun
authors: TB
authors: Ng
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D009336:Necrosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; C082171:lactoferricin B; D007781:Lactoferrin