title: Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study.
abstract: OBJECTIVE
  The aim of the study was to evaluate the effect of mouth cleaning with hinokitiol-containing gel on oral malodor.
  
  
  METHODS
  An open-label, randomized, controlled trial was conducted to assess oral malodor and clinical parameters related to oral malodor before and after mouth cleaning with hinokitiol-containing gel (n = 9) or with gel not including hinokitiol (n = 9). Mouth cleaning included the teeth, gingiva, and tongue and was carried out 3 times per day for 4 weeks.
  
  
  RESULTS
  Organoleptic test (OLT) scores (P = .021), levels of hydrogen sulfide (P = .008) and methyl mercaptan (P = .020), frequency of bleeding on probing, average probing pocket depth, and plaque index significantly improved in the group using hinokitiol. In contrast, only the OLT score (P = .031) significantly improved in the control group after the treatment regimen.
  
  
  CONCLUSIONS
  Mouth cleaning with hinokitiol-containing gel may be effective for reduction of oral malodor.
authors: Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.
authors: Kosaku
authors: K
authors: Iha
authors: Nao
authors: N
authors: Suzuki
authors: Masahiro
authors: M
authors: Yoneda
authors: Toru
authors: T
authors: Takeshita
authors: Takao
authors: T
authors: Hirofuji
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification; D002594:Cetylpyridinium / Q000627:therapeutic use; D002849:Chromatography, Gas; D029779:Cupressaceae; D003774:Dental Plaque Index; D005260:Female; D006209:Halitosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D039821:Monoterpenes / Q000627:therapeutic use*; D009055:Mouth / Q000382:microbiology / Q000473:pathology*; D008517:Phytotherapy; D010865:Pilot Projects; D010938:Plant Oils / Q000627:therapeutic use*; D012463:Saliva / Q000382:microbiology; D014099:Toothbrushing; D014100:Toothpastes / Q000494:pharmacology; D014334:Tropolone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D039821:Monoterpenes; D010938:Plant Oils; D014100:Toothpastes; D014334:Tropolone; D002594:Cetylpyridinium; C009479:beta-thujaplicin