title: The preventive effect of dopamine infusion in rats with abdominal compartment syndrome.
abstract: BACKGROUND
  The most significant perfusion disorder of the intra-abdominal viscera occurs in the abdominal compartment syndrome (ACS). Free oxygen radicals diffuse into the body during the reperfusion phase of ACS. Our aim was to determine the effects of dopamine infusion (3 μg/kg/min) on renal perfusion, cytokine levels, free oxygen radicals, and renal histopathological changes in the presence of ACS in a prospective randomized manner.
  
  
  METHODS
  Twenty-four male Sprague-Dawley rats were randomly divided into four groups (n = 6). Group 1 was used as control. In group 2, air was inflated until the intra-abdominal pressure (IAP) reached 20 mmHg. In group 3, dopamine was infused for 60 min meanwhile IAP was kept at 20 mmHg. In group 4, dopamine was infused for 60 min before IAP rise. After this phase, renal artery (RA) perfusion was measured continuously. Myeloperoxidase activity (MPO), glutathione (GSH), and lipid peroxidation (MDA) levels were measured in tissue samples and histopathological scoring was performed.
  
  
  RESULTS
  Dopamine treatment before and during ACS significantly decreased MPO and MDA levels and also increased renal blood flow and GSH levels. However, histopathological damage was improved simultaneously.
  
  
  CONCLUSIONS
  Dopamine infusion before and during ACS, increases renal perfusion and decreases free oxygen radicals. According to our findings, dopamine infusion may be proposed for the treatment of ACS and perfusion disorders in critically ill patients.
authors: 1 Department of Anesthesiology.
authors: Kemal Tolga
authors: KT
authors: Saracoglu
authors: Ayten
authors: A
authors: Saracoglu
authors: Tumay
authors: T
authors: Umuroglu
authors: Mustafa Umit
authors: MU
authors: Ugurlu
authors: Mustafa
authors: M
authors: Deniz
authors: Fevzi Yilmaz
authors: FY
authors: Gogus
mesh_terms: D000818:Animals; D004298:Dopamine / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D059325:Intra-Abdominal Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology
chemical_list: D008315:Malondialdehyde; D005978:Glutathione; D004298:Dopamine