title: Regulatory potential of COUP-TFs in development: stem/progenitor cells.
abstract: The formation of complex organisms is highly dependent on the differentiation of specialized mature cells from common stem/progenitor cells. The orphan nuclear receptors chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are broadly, but not ubiquitously, expressed in multiple tissues throughout embryonic development and COUP-TFs are indispensible for proper organogenesis. Recently, growing evidence suggests a critical role of COUP-TFs in multiple aspects of stem/progenitor cell biology. In this review, we highlight the progress of COUP-TFs function and its underlying mechanism in driving stem/progenitor cell self-renewal, lineage specification, differentiation, maintenance, and cell identity in diverse tissue types. These studies provide novel insights into future clinical utilities of COUP-TFs in stem cell based therapies and in the management of diseases.
authors: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors: Xin
authors: X
authors: Xie
authors: Ke
authors: K
authors: Tang
authors: Cheng-Tai
authors: CT
authors: Yu
authors: Sophia Y
authors: SY
authors: Tsai
authors: Ming-Jer
authors: MJ
authors: Tsai
mesh_terms: D000818:Animals; D051836:COUP Transcription Factors / Q000378:metabolism*; D047108:Embryonic Development; D006801:Humans; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D051836:COUP Transcription Factors
keywords: COUP-TFs; Stem/progenitor cell
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