title: Two-dimensional liquid chromatography for direct chiral separations: a review.
abstract: Separation of enantiomers remains a challenge owing to their identical physical and chemical properties in an achiral environment, and research on specialized separation techniques such as multidimensional achiral-chiral liquid chromatography continues to resolve individual enantiomers in complex samples. Recent advances in application of multidimensional liquid chromatography applied to chiral analysis are reviewed. For this reason, benefits of achiral-chiral coupling are shown, with emphasis in applications on biological and pharmaceutical fields as well as pesticide analysis. A description of standard instrumental setup in both heart-cut and comprehensive multidimensional liquid chromatography is shown. The most broadly used chiral stationary phases for multidimensional liquid chromatography are summarized. An extensive overview of different interface designs applied to complex samples is presented.
authors: Analytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, E-28040, Madrid, Spain.
authors: María Eugenia
authors: ME
authors: León-González
authors: Noelia
authors: N
authors: Rosales-Conrado
authors: Luis Vicente
authors: LV
authors: Pérez-Arribas
authors: Vanesa
authors: V
authors: Guillén-Casla
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D010575:Pesticides / Q000737:chemistry / Q000302:isolation & purification*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D010575:Pesticides; D004364:Pharmaceutical Preparations
keywords: chiral analysis; enantiomer separation; multidimensional liquid chromatography