title: Non-thermal plasmas induced electrostatic stress on corneocyte desquamation.
abstract: The advent of non-thermal plasma brought a breakthrough in exploring its clinical applications in dermatology to bolster tissue generation in the domain of plasma medicine. This study aimed to investigate the effect of non-thermal plasma on the corneocyte of the skin cells, in treating superficial skin diseases via the process of corneocyte desquamation, a probable mechanism for skin cell proliferation. The postulated brick and mortar arrangement of corneocytes in the stratum corneum was modeled consisting of three corneocytes and three corneodesmosomes in a simulation domain of 40.30 × 3.00 μm² using Maxwell 2D finite element analyzer. The corneocyte desquamation was quantified by the weakening of corneodesmosomes due to electrostatic pressure (~530 MV/m) on the corneodesmosome surface exceeding its tensile strength (~76 MPa). A mathematical model displaying a relationship between the plasma potential and the skin tensile strength is also presented in this investigation. The non-thermal plasma could emerge as a clean and dry therapy to treat superficial skin diseases. Our study propels investigating the interaction of non-thermal plasma with the wet tissue in the deeper layer (dermis) of the skin cells and also, the development of such instruments for a comprehensive skin treatment.
authors: Department of Biomedical Engineering, College of Medical Science, Catholic University of Daegu, Republic of Korea.
authors: Pawan K
authors: PK
authors: Tiwari
authors: Yeon Soo
authors: YS
authors: Lee
mesh_terms: D003198:Computer Simulation; D003896:Desmosomes / Q000187:drug effects / Q000378:metabolism; D004553:Electric Conductivity; D006801:Humans; D058626:Plasma Gases / Q000494:pharmacology; D012867:Skin / Q000166:cytology* / Q000187:drug effects*; D055672:Static Electricity; D013314:Stress, Mechanical
chemical_list: D058626:Plasma Gases