title: Targeting interleukin-22 in psoriasis.
abstract: Interleukin-22 (IL-22) is an IL-10 family cytokine that was recently discovered to be released by T helper 17 (Th17) cells, Th22 cells, etc. Recently, there is emerging evidence that IL-22 is involved in the development and pathogenesis of psoriasis. For instance, IL-22 can inhibit keratinocyte terminal differentiation and can induce psoriasis-like epidermis alterations; serum IL-22 levels were correlated with the disease severity of psoriasis patients, and IL-22 mRNA was positively expressed in the psoriatic skin lesions, but negatively expressed in the normal controls. All these findings suggest that IL-22 may be implicated in psoriasis; therapeutics targeting IL-22 may have promise as a potential therapeutic target for treating psoriasis. In the present review, we summarize recent advances on the role of IL-22 in the pathogenesis and treatment of psoriasis.
authors: Department of Oncology, The Fist Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China, ayfy_hjq@163.com.
authors: Ji-Qing
authors: JQ
authors: Hao
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D007378:Interleukins / Q000097:blood / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D016753:Interleukin-10; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22; C508609:IL10 protein, human
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