title: The role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of ovarian cancer relapse.
abstract: Nowadays the standard clinical management for advanced epithelial ovarian cancer is constituted by primary cytoreductive surgery associated to adjuvant systemic chemotherapy. Even if this first-line chemotherapy shows a high rate of complete responses, the disease recurrences occur especially in stage-III patients. Actually an option for this subset of patients is represented by secondary cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy that represents a promising therapy, having shown positive results in terms of median overall survival, progression free survival and overall survival. However, a much more research is still required especially by prospective randomised trials to improve outcomes in recurrent ovarian cancer.
authors: General Surgery Unit, Department of Human Pathology, University of Messina, Via Consolare Valeria, 98125, Messina, Italy, edoardosaladino@hotmail.com.
authors: E
authors: E
authors: Saladino
authors: F
authors: F
authors: Fleres
authors: S
authors: S
authors: Irato
authors: C
authors: C
authors: Famulari
authors: A
authors: A
authors: Macrì
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010537:Peritoneum
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