title: Elevated preoperative C-reactive protein levels are a risk factor for the development of postoperative infectious complications following elective colorectal surgery.
abstract: OBJECTIVE
  The present study was designed to evaluate the relationship between the preoperative C-reactive protein levels and the incidence of postoperative infectious complications in patients undergoing colorectal surgery.
  
  
  METHODS
  This study was a retrospective cohort study of a consecutive series of 464 patients who underwent elective colorectal resection between April 2010 and March 2012. We evaluated the patients' preoperative conditions, including the preoperative C-reactive protein levels, surgical content, and incidence of postoperative infectious complications.
  
  
  RESULTS
  Postoperative infectious complications occurred in 133 patients (28.7 %). In the univariate analysis, male gender, rectal surgery, open surgery, elevated preoperative white blood cell counts, elevated preoperative C-reactive protein levels, extended operative times, large amounts of blood loss during surgery, and ostomy formation were found to be significantly associated with the incidence of postoperative infectious complications. In the multivariate analysis, elevated preoperative C-reactive protein levels (OR per mg/dl = 1.17, 95 % CI = 1.02-1.37, P = 0.02) and large amounts of blood loss during surgery (OR per 100 g = 1.13, 95 % CI = 1.06-1.23, P < 0.01) were found to be independently associated with the incidence of postoperative infectious complications.
  
  
  CONCLUSIONS
  This study provides evidence of an association between the preoperative C-reactive protein level and the incidence of postoperative infectious complications following colorectal surgery, which should be further confirmed in prospective and appropriately designed studies.
authors: Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan, drs1020@ndmc.ac.jp.
authors: Toru
authors: T
authors: Kubo
authors: Satoshi
authors: S
authors: Ono
authors: Hideki
authors: H
authors: Ueno
authors: Eiji
authors: E
authors: Shinto
authors: Junji
authors: J
authors: Yamamoto
authors: Kazuo
authors: K
authors: Hase
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003082:Colectomy / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery*; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D004760:Enterocolitis / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011014:Pneumonia / Q000097:blood / Q000453:epidemiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000097:blood / Q000453:epidemiology*; D014552:Urinary Tract Infections / Q000097:blood / Q000453:epidemiology
chemical_list: D002097:C-Reactive Protein
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