title: Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together.
abstract: Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodelling and some grade of inflammation, and sarcopenia, a condition of pathological muscle weakness associated with altered muscle mass, strength, and function, are prevalent disorders in elderly people. There is increasing evidence that decline in lower limb muscle strength is associated with knee or hip osteoarthritis in a context of pain, altered joint stability, maladapted postures and defective neuromuscular communication. At the cellular and molecular levels, chondrocytes and myoblasts share common pathological targets and pathways, and the close anatomical location of both cell types suggest a possibility of paracrine communication. In this review, we examine the relationship between osteoarthritis and sarcopenia in the musculoskeletal field, and discuss the potential advantage of concomitant therapies, or how each disorder may benefit from treatment of the other.
authors: Institut de Recherches Servier, Department of Rheumatology, 11 rue des Moulineaux, Suresnes 92150, France. Electronic address: frederic.deceuninck@fr.netgrs.com.
authors: Frédéric
authors: F
authors: De Ceuninck
authors: Institut de Recherches Servier, Department of Rheumatology, 11 rue des Moulineaux, Suresnes 92150, France.
authors: Armel
authors: A
authors: Fradin
authors: Institut de Recherches Servier, Department of Rheumatology, 11 rue des Moulineaux, Suresnes 92150, France.
authors: Philippe
authors: P
authors: Pastoureau
mesh_terms: D000368:Aged; D000818:Animals; D002356:Cartilage / Q000473:pathology; D019902:Chondrocytes / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000473:pathology; D032446:Myoblasts / Q000378:metabolism; D010003:Osteoarthritis / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D019899:Paracrine Communication / Q000502:physiology; D055948:Sarcopenia / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology