title: IVIg treatment reduces catalytic antibody titers of renal transplanted patients.
abstract: Catalytic antibodies are immunoglobulins endowed with enzymatic activity. Catalytic IgG has been reported in several human autoimmune and inflammatory diseases. In particular, low levels of catalytic IgG have been proposed as a prognostic marker for chronic allograft rejection in patients undergoing kidney transplant. Kidney allograft is a treatment of choice for patients with end-stage renal failure. Intravenous immunoglobulins, a therapeutic pool of human IgG, is used in patients with donor-specific antibodies, alone or in conjunction with other immunosuppressive treatments, to desensitize the patients and prevent the development of acute graft rejection. Here, we followed for a period of 24 months the levels of catalytic IgG towards the synthetic peptide Pro-Phe-Arg-methylcoumarinimide in a large cohort of patients undergoing kidney transplantation. Twenty-four percent of the patients received IVIg at the time of transplantation. Our results demonstrate a marked reduction in levels of catalytic antibodies in all patients three months following kidney transplant. The decrease was significantly pronounced in patients receiving adjunct IVIg therapy. The results suggests that prevention of acute graft rejection using intravenous immunoglobulins induces a transient reduction in the levels of catalytic IgG, thus potentially jeopardizing the use of levels of catalytic antibodies as a prognosis marker for chronic allograft nephropathy.
authors: Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Unité Mixte de Recherche S 872, Paris, France.
authors: Ankit
authors: A
authors: Mahendra
authors: Ivan
authors: I
authors: Peyron
authors: Cécile
authors: C
authors: Dollinger
authors: Laurent
authors: L
authors: Gilardin
authors: Meenu
authors: M
authors: Sharma
authors: Bharath
authors: B
authors: Wootla
authors: Séverine
authors: S
authors: Padiolleau-Lefevre
authors: Alain
authors: A
authors: Friboulet
authors: Didier
authors: D
authors: Boquet
authors: Christophe
authors: C
authors: Legendre
authors: Srinivas V
authors: SV
authors: Kaveri
authors: Olivier
authors: O
authors: Thaunat
authors: Sébastien
authors: S
authors: Lacroix-Desmazes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017151:Antibodies, Catalytic / Q000097:blood / Q000378:metabolism*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D006868:Hydrolysis; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
chemical_list: D017151:Antibodies, Catalytic; D001323:Autoantibodies; D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
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