title: Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise.
abstract: Resveratrol and quercetin function as antioxidants and anti-inflammatories in vitro, but these mechanisms have been minimally examined in combination in exercising humans. The purpose of this investigation was to examine supplementation as a countermeasure against oxidative stress and inflammation in response to exercise. Fourteen athletes were randomly assigned, in a double-blind crossover design, to a resveratrol and quercetin combination (RQ) (120 mg resveratrol and 225 mg quercetin for 6 days and 240 mg resveratrol and 450 mg quercetin on day 7 just prior to exercise) or to placebo (P). There was a 1-week washout between trials. Blood was taken at baseline, pre-exercise, immediately after exercise, and 1 h after exercise. Plasma was analyzed for oxidative stress (F2-isoprostanes and protein carbonyls), antioxidant capacity (ferric-reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), oxygen radical absorptive capacity (ORAC)), and inflammation (cytokine interleukin (IL)-8 and C-reactive protein (CRP)). Statistical design utilized a 2 × 3 ANOVA and Student's t test. Pre-exercise values were not different from baseline for any measure. The postexercise increase in F2-isoprostanes was significantly less (p = 0.039 interaction) with RQ (68%) than with P (137%). Protein carbonyls, FRAP, ORAC, and TEAC significantly increased after exercise but were not affected by treatment. IL-8 and CRP increased significantly immediately after exercise but were not affected by treatment. These data indicate that RQ significantly reduces exercise-induced lipid peroxidation without associated changes in inflammation or plasma antioxidant status.
authors: Department of Nutrition and Health Care Management, Appalachian State University, Boone, NC 28608, USA.
authors: Lisa S
authors: LS
authors: McAnulty
authors: Lindsey E
authors: LE
authors: Miller
authors: Peter A
authors: PA
authors: Hosick
authors: Alan C
authors: AC
authors: Utter
authors: John C
authors: JC
authors: Quindry
authors: Steven R
authors: SR
authors: McAnulty
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D007249:Inflammation; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D011794:Quercetin