title: Q10-triggered facial vitiligo.
abstract: BACKGROUND
  Generation and accumulation of reactive oxygen/nitrogen species in the epidermis of patients with vitiligo has been widely documented. Moreover, semiquinone radical-mediated sensitivity has been shown in blood lymphocytes of these patients.
  
  
  OBJECTIVE
  To determine the possible mechanism behind Q10-induced facial vitiligo.
  
  
  METHODS
  This was a clinical assessment supported by in vivo Fourier transform-Raman spectroscopy and repigmentation.
  
  
  RESULTS
  Topical Q10 application generated hydrogen peroxide (H2 O2 ) leading in turn to facial vitiligo in susceptible individuals. Proof of the basic result stemmed from reduction of epidermal H2 O2 by using narrowband ultraviolet B-activated propseudocatalase PC-KUS in association with cessation of depigmentation and repigmentation of the lost skin colour.
  
  
  CONCLUSIONS
  Over-the-counter availability of Q10-containing topical formulations can be harmful to individuals susceptible to vitiligo.
authors: Institute for Pigmentary Disorders in Association with EM Arndt University, Greifswald, Germany; Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, U.K.
authors: K U
authors: KU
authors: Schallreuter
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002374:Catalase / Q000008:administration & dosage; D003358:Cosmetics / Q000009:adverse effects; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000009:adverse effects; D062327:Skin Lightening Preparations / Q000008:administration & dosage / Q000009:adverse effects*; D014451:Ubiquinone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014820:Vitiligo / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D003358:Cosmetics; D004366:Nonprescription Drugs; D062327:Skin Lightening Preparations; D014451:Ubiquinone; D006861:Hydrogen Peroxide; C038109:pseudocatalase; D002374:Catalase; C024989:coenzyme Q10