title: Allele frequency distribution of 1691G >A F5 (which confers Factor V Leiden) across Europe, including Slavic populations.
abstract: The allele 1691A F5, conferring Factor V Leiden, is a common risk factor in venous thromboembolism. The frequency distribution for this allele in Western Europe has been well documented; but here data from Central, Eastern and South-Eastern Europe has been included. In order to assess the significance of the collated data, a chi-squared test was applied, and Tukey tests and z-tests with Bonferroni correction were compared.
  
  
  RESULTS
  A distribution with a North-Southeast band of high frequency of the 1691A F5 allele was discovered with a pocket including some Southern Slavic populations with low frequency. European countries/regions can be arbitrarily delimited into low (group 1, <2.8 %, mean 1.9 % 1691A F5 allele) or high (group 2, ≥2.8 %, mean 4.0 %) frequency groups, with many significant differences between groups, but only one intra-group difference (the Tukey test is suggested to be superior to the z-tests).
  
  
  CONCLUSIONS
  In Europe a North-Southeast band of 1691A F5 high frequency has been found, clarified by inclusion of data from Central, Eastern and South-Eastern Europe, which surrounds a pocket of low frequency in the Balkans which could possibly be explained by Slavic migration. There seem to be no indications of variation in environmental selection due to geographical location.
authors: Jeremy S C
authors: JS
authors: Clark
authors: Grażyna
authors: G
authors: Adler
authors: Nermin N
authors: NN
authors: Salkic
authors: Andrzej
authors: A
authors: Ciechanowicz
mesh_terms: D000483:Alleles; D005060:Europe; D005165:Factor V / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D058974:Phylogeography; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V
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