title: The impact of short daily hemodialysis on anemia and the quality of life in Chinese patients.
abstract: Anemia is a frequent complication in hemodialysis patients. Compared to conventional hemodialysis (CHD), short daily hemodialysis (sDHD) has been reported to be effective in many countries except China. The aim of the present study was to determine whether sDHD could improve anemia and quality of life (QOL) for Chinese outpatients with end-stage renal disease. Twenty-seven patients (16 males/11 females) were converted from CHD to sDHD. All laboratory values were measured before conversion (baseline), at 3 months after conversion (sDHD1), and at 6 months after conversion (sDHD2). The patient's QOL was evaluated at baseline and 6 months after conversion using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). Hemoglobin concentration increased significantly from 107.4 ± 7.9 g/L at baseline to 114.4 ± 6.8 g/L (P<0.05) at sDHD1, and 118.3±8.4 g/L (P<0.001) at sDHD2 (Student paired t-test). However, the dose requirement for erythropoietin decreased from 6847.8 ± 1057.3 U/week at baseline to 5869.6±1094.6 U/week (P<0.05) at sDHD2. Weekly stdKt/V increased significantly from 2.05±0.13 at baseline to 2.73±0.20 (P<0.001) at sDHD1, and 2.84±0.26 (P<0.001) at sDHD2. C-reactive protein decreased from baseline to sDHD1 and sDHD2, but without statistically significant differences. Physical and mental health survey scores increased in the 6 months following conversion to sDHD. sDHD may increase hemoglobin levels, decrease exogenous erythropoietin dose requirements, and improve QOL in Chinese hemodialysis patients compared to CHD. A possible mechanism for improvement of clinical outcomes may be optimized management of uremia associated with the higher efficiency of sDHD.
authors: Qilu Hospital, Shandong University, Department of Nephrology, Jinan, China.
authors: J L
authors: JL
authors: Jiang
authors: W
authors: W
authors: Ren
authors: J
authors: J
authors: Song
authors: Q L
authors: QL
authors: Sun
authors: X Y
authors: XY
authors: Xiao
authors: X Z
authors: XZ
authors: Diao
authors: Y H
authors: YH
authors: Huang
authors: L
authors: L
authors: Lan
authors: P
authors: P
authors: Wang
authors: Z
authors: Z
authors: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology*; D044466:Asian People; D002681:China; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D006435:Renal Dialysis / Q000379:methods*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D004921:Erythropoietin; D007501:Iron
references: Trans Am Soc Artif Intern Organs. 1968;14:152-9
references: 5701525
references: Clin J Am Soc Nephrol. 2012 May;7(5):782-94
references: 22422538
references: Blood Purif. 2009;28(3):159-64
references: 19590183
references: BMC Nephrol. 2011 Dec 05;12:66
references: 22142369
references: Hemodial Int. 2012 Jan;16(1):31-7
references: 22284696
references: Am J Kidney Dis. 2003 Jul;42(1 Suppl):42-8
references: 12830443
references: Kidney Int. 2004 Mar;65(3):990-8
references: 14871419
references: Nephrol Dial Transplant. 2006 Sep;21(9):2529-35
references: 16720589
references: Am J Kidney Dis. 2007 Sep;50(3):471-530
references: 17720528
references: Am J Kidney Dis. 2003 Jul;42(1 Suppl):36-41
references: 12830442
references: Am J Kidney Dis. 1999 Dec;34(6):1089-95
references: 10585319
references: Kidney Int. 2012 Sep;82(5):561-9
references: 22622497
references: Nat Clin Pract Nephrol. 2008 Jan;4(1):47-57
references: 18094727
references: ASAIO J. 2001 Sep-Oct;47(5):449-55
references: 11575812
references: Nephron Clin Pract. 2003;95(1):c23-30
references: 14520018
references: Nephrol Dial Transplant. 2008 Aug;23(8):2634-46
references: 18390567
references: Korean J Intern Med. 2007 Sep;22(3):186-91
references: 17939336
references: Am J Kidney Dis. 2001 Aug;38(2):371-6
references: 11479164
references: Am J Kidney Dis. 2002 Aug;40(2):339-47
references: 12148107
references: Hemodial Int. 2004 Apr 1;8(2):151-8
references: 19379411
references: Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S95-8
references: 11158870
references: Nephrol Dial Transplant. 2006 Jan;21(1):166-75
references: 16169869
references: ASAIO J. 2002 Jan-Feb;48(1):57-61
references: 11814098
references: Am J Kidney Dis. 2003 Nov;42(5):1020-35
references: 14582046
references: Contrib Nephrol. 2011;171:261-265
references: 21625122
references: ASAIO J. 2005 May-Jun;51(3):236-41
references: 15968953
references: Adv Chronic Kidney Dis. 2007 Jul;14(3):e35-42
references: 17603973