title: A case of severe chronic progressive axonal polyradiculoneuropathy temporally associated with anti-CV2/CRMP5 antibodies.
abstract: OBJECTIVE
  The involvement of the peripheral nervous system by anti-CV2/CRMP5 paraneoplastic antibodies is typically encountered as a mixed sensorimotor polyneuropathy. We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.
  
  
  METHODS
  Review of the patient's chart, nerve conduction/electromyographic studies, and nerve biopsy.
  
  
  RESULTS
  A 51-year-old man presented with a progressive quadriparesis over a 4-month period. Extensive evaluation for potential etiologies was significant only for positive anti-CV2/CRMP5 antibodies without detection of an underlying neoplasm. Despite multiple immunomodulatory therapies, the patient progressed and demonstrated electrodiagnostic evidence for a chronic axonal polyradiculoneuropathy with ongoing denervation. The patient eventually died of respiratory failure.
  
  
  CONCLUSIONS
  This case adds to the clinical spectrum of the peripheral nervous system involvement in patients with paraneoplastic anti-CV2/CRMP5 antibodies.
authors: Department of Neurology, Baylor College of Medicine, Houston, TX, USA. yousefhannawi@yahoo.com
authors: Yousef
authors: Y
authors: Hannawi
authors: Corey E
authors: CE
authors: Goldsmith
authors: Joseph S
authors: JS
authors: Kass
authors: Adriana
authors: A
authors: Olar
authors: Eroboghene E
authors: EE
authors: Ubogu
authors: Yogeshwar V
authors: YV
authors: Kalkonde
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D017809:Fatal Outcome; D006801:Humans; D006867:Hydrolases; D008297:Male; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases