title: Integration of autophagy and anoikis resistance in solid tumors.
abstract: Macroautophagy or autophagy is a lysosome-dependent process in which enzymatic degradation and recycling of cytosolic components occurred due to stressful conditions. This cellular arrangement imparts anoikis resistance in solid tumors. Anoikis, a special form of apoptosis occurring when cells detach from the extracellular matrix, is a critical mechanism in maintaining tissue homeostasis and development. Anoikis resistance facilitates tumorigenesis and metastasis. However, the complexity of the role of autophagy in tumor is underscored by evidence that autophagy can function as both a pro-survival or pro-death depending on the context and the stimuli, which are likely exploitable for tumor therapy. This review focuses on recent progress in understanding anoikis resistance and autophagy signaling, paying particular attention to its relevance in solid tumor metastasis.
authors: Department of Biochemistry and Molecular Biology, Heping District, Tianjin, 300070, China.
authors: Jie
authors: J
authors: Yang
authors: Zhichao
authors: Z
authors: Zheng
authors: Xiaojie
authors: X
authors: Yan
authors: Xia
authors: X
authors: Li
authors: Zhe
authors: Z
authors: Liu
authors: Zhenyi
authors: Z
authors: Ma
mesh_terms: D000818:Animals; D023102:Anoikis; D001343:Autophagy; D002450:Cell Communication; D006801:Humans; D009369:Neoplasms / Q000473:pathology*
keywords: anoikis; anoikis resistance; autophagic cell death; metastasis; solid tumor