title: Either main or accessory olfactory system signaling can mediate the rewarding effects of estrous female chemosignals in sexually naive male mice.
abstract: A long-held view has been that interest of male mice in female body odors reflects an activation of reward circuits in the male brain following their detection by the vomeronasal organ (VNO) and processing via the accessory olfactory system. We found that adult, sexually naive male mice acquired a conditioned place preference (CPP) after repeatedly receiving estrous female urine on the nose and being placed in an initially nonpreferred chamber with soiled estrous bedding on the floor. CPP was not acquired in control mice that received saline on the nose before being placed in a nonpreferred chamber with clean bedding. Robust acquisition of a CPP using estrous female odors as the reward persisted in separate groups of mice in which VNO-accessory olfactory function was disrupted by bilateral lesioning of the accessory olfactory bulb (AOB) or in which main olfactory function was disrupted by zinc sulfate lesions of the main olfactory epithelium (MOE). By contrast, no CPP was acquired for estrous odors in males that received combined AOB and MOE lesions. Either the main or the accessory olfactory system suffices to mediate the rewarding effects of estrous female odors in the male mouse, even in the absence of prior mating experience. The main olfactory system is part of the circuitry that responds to chemosignals involved in motivated behavior, a role that may be particularly important for humans who lack a functional accessory olfactory system.
authors: Department of Biology.
authors: Wayne J
authors: WJ
authors: Korzan
authors: Mihael
authors: M
authors: Freamat
authors: Adam G
authors: AG
authors: Johnson
authors: James A
authors: JA
authors: Cherry
authors: Michael J
authors: MJ
authors: Baum
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological; D030762:Estrous Cycle / Q000502:physiology* / Q000652:urine; D005260:Female; D008297:Male; D051379:Mice; D009833:Olfactory Pathways / Q000502:physiology*; D010675:Pheromones / Q000502:physiology*; D012201:Reward
chemical_list: D010675:Pheromones
references: Genes Brain Behav. 2009 Oct;8(7):639-49
references: 19799641
references: Nature. 2006 Nov 16;444(7117):308-15
references: 17108955
references: Cell Rep. 2012 Jul 26;2(1):76-88
references: 22840399
references: Front Neuroanat. 2012 Aug 21;6:33
references: 22933993
references: Neuron. 2001 Aug 30;31(4):661-8
references: 11545724
references: Eur J Neurosci. 2006 Jun;23(12):3385-90
references: 16820028
references: Behav Neurosci. 2004 Apr;118(2):356-64
references: 15113261
references: J Gen Physiol. 2010 Jan;135(1):3-13
references: 20038523
references: Biol Psychol. 2005 Dec;70(3):197-204
references: 16242537
references: Nat Rev Neurosci. 2004 Jun;5(6):483-94
references: 15152198
references: Hum Brain Mapp. 2011 Mar;32(3):450-60
references: 20578170
references: Science. 2011 Jan 14;331(6014):226-30
references: 21212322
references: Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Sep;128(4):184-90
references: 21377439
references: Exp Brain Res. 1987;69(1):7-18
references: 3325300
references: Chem Senses. 2011 Mar;36(3):251-60
references: 21177285
references: Neuroscience. 1996 Apr;71(4):1063-72
references: 8684610
references: Front Neuroanat. 2011 Aug 22;5:54
references: 22007159
references: Science. 1980 Nov 28;210(4473):1039-41
references: 7434016
references: Cells Tissues Organs. 2009;190(5):256-85
references: 19287129
references: J Neurosci. 2009 Jun 17;29(24):7658-66
references: 19535577
references: Behav Brain Res. 2012 Jan 15;226(2):538-47
references: 22019343
references: Horm Behav. 2002 Mar;41(2):213-9
references: 11855906
references: J Comp Neurol. 1978 Feb 1;177(3):381-96
references: 412879
references: Eur J Neurosci. 2009 Feb;29(3):624-34
references: 19187265
references: J Neurosci. 2007 Feb 7;27(6):1261-5
references: 17287500
references: Brain Res. 1982 May 20;240(1):27-41
references: 7093718
references: J Comp Neurol. 2012 Jun 1;520(8):1819-30
references: 22120520
references: Physiol Behav. 2008 Feb 27;93(3):467-73
references: 17991495
references: Behav Neurosci. 2008 Oct;122(5):963-73
references: 18823153
references: Physiol Behav. 1995 Sep;58(3):529-34
references: 8587961
references: Biol Psychiatry. 2010 May 1;67(9):864-71
references: 20034613
references: Physiol Behav. 2006 Apr 15;87(4):781-8
references: 16516252
references: Eur J Neurosci. 2007 Jul;26(2):463-75
references: 17623023
references: Behav Neurosci. 2006 Aug;120(4):925-36
references: 16893298
references: Physiol Behav. 2001 Jul;73(4):457-69
references: 11495649
references: J Neurosci. 2004 Apr 7;24(14):3703-10
references: 15071119
references: Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2471-6
references: 17267604
references: Nat Neurosci. 2012 Sep;15(9):1236-44
references: 22842147
references: Science. 2002 Feb 22;295(5559):1493-500
references: 11823606
references: Chem Senses. 2007 Feb;32(2):139-48
references: 17085679
references: J Comp Neurol. 1994 Aug 15;346(3):403-34
references: 7527806
references: Neuroscience. 2011 Jan 13;172:196-204
references: 21070839
references: Nature. 2012 Nov 8;491(7423):212-7
references: 23064228