title: Dynamic neural network reorganization associated with second language vocabulary acquisition: a multimodal imaging study.
abstract: It remains unsettled whether human language relies exclusively on innately privileged brain structure in the left hemisphere or is more flexibly shaped through experiences, which induce neuroplastic changes in potentially relevant neural circuits. Here we show that learning of second language (L2) vocabulary and its cessation can induce bidirectional changes in the mirror-reverse of the traditional language areas. A cross-sectional study identified that gray matter volume in the inferior frontal gyrus pars opercularis (IFGop) and connectivity of the IFGop with the caudate nucleus and the superior temporal gyrus/supramarginal (STG/SMG), predominantly in the right hemisphere, were positively correlated with L2 vocabulary competence. We then implemented a cohort study involving 16 weeks of L2 training in university students. Brain structure before training did not predict the later gain in L2 ability. However, training intervention did increase IFGop volume and reorganization of white matter including the IFGop-caudate and IFGop-STG/SMG pathways in the right hemisphere. These "positive" plastic changes were correlated with the gain in L2 ability in the trained group but were not observed in the control group. We propose that the right hemispheric network can be reorganized into language-related areas through use-dependent plasticity in young adults, reflecting a repertoire of flexible reorganization of the neural substrates responding to linguistic experiences.
authors: Department of Functional Brain Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Chihiro
authors: C
authors: Hosoda
authors: Kanji
authors: K
authors: Tanaka
authors: Tadashi
authors: T
authors: Nariai
authors: Manabu
authors: M
authors: Honda
authors: Takashi
authors: T
authors: Hanakawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D019303:Multilingualism; D017711:Nonlinear Dynamics; D010551:Personality; D014825:Vocabulary; D055815:Young Adult
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