title: Association study of chemokine (C-C motif) ligand 5 gene polymorphism and papillary thyroid cancer.
abstract: The association between polymorphism of CC chemokine ligand 5 (CCL5) and cancer has been reported in several studies, however, there is no data in papillary thyroid cancer (PTC).
  
  
  OBJECTIVE
  The aim of this study was to investigate whether a promoter single nucleotide polymorphisms (SNP) in CCL5 contributes to the development of PTC and assess the relationships between the CCL5 SNP and the cliniopathologic characteristics of PTC.
  
  
  METHODS
  One promoter SNP (rs2107538, -281C/T) in CCL5 was genotyped using direct sequencing in 93 PTC patients and 212 healthy controls. Genetic data were analyzed using SNPStats, Helixtree, and SNPAnalyzer. PTC patients were dichotomized and compared with respect to cliniopathologic characteristics of PTC.
  
  
  RESULTS
  An association was evident between PTC and SNP (rs2107538) in CCL5 [codominant model 2 (T/T vs. C/C), OR = 2.74, 95% CI = 1.18-6.37, p = .019; dominant model, OR = 2.25, 95% CI = 1.01-5.03, p = .049; recessive model, OR = 1.73, 95% CI = 1.06-2.82, p = .030]. When the genetic relationships between SNP and subgroups of PTC patients were assessed, SNP rs2107538 in CCL5 was not associated with any clinicopathologic characteristics of PTC.
  
  
  CONCLUSIONS
  SNP in the CCL5 -281 promoter gene could increase the risk of developing PTC in Koreans.
authors: 1 Department of Otorhinolaryngology-Head and Neck Surgery, Kangdong Sacred Heart Hospital, School of Medicine, Hallym University, Seoul, Republic of Korea.
authors: Kee Hwan
authors: KH
authors: Kwon
authors: Young Chan
authors: YC
authors: Lee
authors: Joo-Ho
authors: JH
authors: Chung
authors: Young Gyu
authors: YG
authors: Eun
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary; D018946:Chemokine CCL5 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5