title: The two-edged sword: vasculitis associated with HIV and hepatitis C coinfection.
abstract: Vasculitis has long been associated with chronic viral infections, thus the twin perils of the infection and the immune response against it that bedevils the specialties of infection and immunity. After HIV was identified, it too became associated with vasculitic syndromes. Later, hepatitis C virus was also isolated, identified and described with its own spectrum of vasculitic diseases, including hepatitis C virus-associated cryoglobulinaemia. With the increasing prevalence of HIV and hepatitis C virus coinfection, there has come an increasing recognition of the range of vasculitides that can occur in this population leading to significant morbidity, diagnostic and treatment challenges. In this review, we examine the epidemiology, pathogenesis and general principles of treatment of these systemic diseases in HIV/hepatitis C virus coinfected individuals.
authors: Department of Infectious Diseases, Southern Health, Clayton, Australia.
authors: Samar
authors: S
authors: Ojaimi
authors: Ming-Wei
authors: MW
authors: Lin
authors: Kasha P
authors: KP
authors: Singh
authors: Ian
authors: I
authors: Woolley
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D060085:Coinfection; D003449:Cryoglobulinemia / Q000276:immunology / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D014657:Vasculitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000821:virology
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral
keywords: AIDS; HIV; HIV/HCV coinfection; cryoglobulinaemia; hepatitis C; vasculitis