title: Chemical synthesis of U1 snRNA derivatives.
abstract: U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA.
authors: Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Midoriku, Yokohama 226-8501, Japan. aohkubo@bio.titech.ac.jp
authors: Akihiro
authors: A
authors: Ohkubo
authors: Yasushi
authors: Y
authors: Kondo
authors: Makoto
authors: M
authors: Suzuki
authors: Haruki
authors: H
authors: Kobayashi
authors: Takashi
authors: T
authors: Kanamori
authors: Yoshiaki
authors: Y
authors: Masaki
authors: Kohji
authors: K
authors: Seio
authors: Kiyoshi
authors: K
authors: Nagai
authors: Mitsuo
authors: M
authors: Sekine
mesh_terms: D015394:Molecular Structure; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D012333:RNA, Messenger; D012342:RNA, Small Nuclear; C405483:U1 small nuclear RNA
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