title: In aged men, central vessel transmural pressure is reduced by brief Valsalva manoeuvre during strength exercise.
abstract: A brief Valsalva manoeuvre, lasting 2-3 s, performed by young healthy men during strength exercise reduces transmural pressure acting on intrathoracic arteries. In this study, we sought to verify this finding in older men. Twenty normotensive, prehypertensive and moderately hypertensive otherwise healthy men 46-69 years old performed knee extensions combined with inspiration or with brief Valsalva manoeuvre performed at 10, 20 and 40 mmHg mouth pressure. Same respiratory manoeuvres were also performed at rest. Non-invasively measured blood pressure, knee angle, respiratory airflow and mouth pressure were continuously registered. In comparison to inspiration, estimated transmural pressure acting on thoracic arteries changed slightly and insignificantly during brief Valsalva manoeuvre at 10 and 20 mmHg mouth pressure. At 40 mmHg mouth pressure, transmural pressure declined at rest (-8·8 ± 11·4 mmHg) and during knee extension (-12·1 ± 11·9 mmHg). This decline ensued, as peak systolic pressure increase caused by this manoeuvre, was distinctly <40 mmHg. Only a main effect of mouth pressure was revealed (P<0·001) and neither exercise nor interaction between these factors, what suggests that transmural pressure decline, depended mainly on intrathoracic pressure developed during brief Valsalva manoeuvre. Resting blood pressure did not influence the effect of brief Valsalva manoeuvre on transmural pressure.
authors: Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Experimental and Clinical Physiology, Medical University of Warsaw, Warsaw, Poland.
authors: Wiktor
authors: W
authors: Niewiadomski
authors: Anna
authors: A
authors: Pilis
authors: Anna
authors: A
authors: Strasz
authors: Dorota
authors: D
authors: Laskowska
authors: Anna
authors: A
authors: Gąsiorowska
authors: Karol
authors: K
authors: Pilis
authors: Gerard
authors: G
authors: Cybulski
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000503:physiopathology*; D058246:Prehypertension / Q000503:physiopathology; D055070:Resistance Training; D012119:Respiration; D012737:Sex Factors; D013895:Thoracic Arteries / Q000503:physiopathology*; D013997:Time Factors; D014636:Valsalva Maneuver
keywords: brief Valsalva manoeuvre; elderly; hypertension; men; strength training; transmural pressure