title: Morphologic characteristics of blastic plasmacytoid dendritic cell neoplasm: a case report.
abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, despite chemotherapy, died within a 12-month period. The electron microscopy findings - microvillous processes, nuclei with slight irregularities, a moderate amount of heterochromatin, and rough endoplasmic reticulum in the form of long, narrow profiles, often in parallel arrangements - taken together, serve to distinguish BPDCN from other neoplastic cells, such as monocytes, plasma cells and the cells of chronic lymphocyte leukemia.
authors: Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , China and.
authors: Yongxin
authors: Y
authors: Ru
authors: Peihong
authors: P
authors: Zhang
authors: Shuxu
authors: S
authors: Dong
authors: Huijun
authors: H
authors: Wang
authors: Shixuan
authors: S
authors: Zhao
authors: Yingchang
authors: Y
authors: Mi
authors: Brian
authors: B
authors: Eyden
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003713:Dendritic Cells / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology*; D008297:Male