title: Association between the adiponectin +45T>G genotype and risk of cardiovascular disease: a meta-analysis.
abstract: BACKGROUND
  Numerous studies have investigated the association between adiponectin +45 nucleotide T/G (+45T>G) polymorphisms and cardiovascular disease (CVD). However, these studies have been inconclusive because of obvious inconsistencies among results. The present study aims to quantify the strength of the association between +45T>G (rs2241766) in the adiponectin gene and the risk of CVD.
  
  
  METHODS
  We searched the PubMed, Embase, and Wangfang databases for studies related to the association between the adiponectin +45T>G genotype and the risk of CVD. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association.
  
  
  RESULTS
  A total of 28 case-control studies, with 12,378 CVD cases and 19,368 controls, were included in the meta-analysis. The meta-analysis of the 28 studies showed that the single-nucleotide polymorphism (SNP) +45T>G genotype was associated with an increased risk of CVD (random-effects OR = 1.22, 95% CI 1.08-1.39, p = 0.002). After adjusting for heterogeneity, the meta-analysis showed that the SNP +45T>G genotype was associated with the risk of CVD in the analyses of the total population and the Caucasian population (for the total population, fixed-effects OR = 1.11, 95% CI 1.01-1.23, p = 0.012; for the Caucasian population, fixed-effects OR = 1.16, 95% CI 1.01-1.34, p = 0.039). No significant association was found in other populations. Evidence of publication bias was observed in the meta-analysis.
  
  
  CONCLUSIONS
  A significant association between rs2241766 in the adiponectin gene and CVD was established by the meta-analysis.
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
authors: Donghui
authors: D
authors: Zhou
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China. Electronic address: yuanzhe_jin@126.com.
authors: Yuanzhe
authors: Y
authors: Jin
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
authors: Fengchen
authors: F
authors: Yao
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
authors: Zhiying
authors: Z
authors: Duan
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
authors: Qi
authors: Q
authors: Wang
authors: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
authors: Jing
authors: J
authors: Liu
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D039781:PubMed; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: D052242:Adiponectin
keywords: +45T>G; Adiponectin; Cardiovascular disease; Meta-analysis; Polymorphism