title: Adaptive inflammatory microenvironment for cell-based regeneration in ischemic cardiovascular disease.
abstract: Cell-based therapy has emerged to be a promising strategy for alleviating the heavy burden of ischemic cardiovascular disease for nearly two decades, despite a variety of pending questions about its availability and efficacy. One question is whether and how the cells behave for regeneration in vivo, which could be limited or potentiated by the inflammatory microenvironment following myocardial infarction or critical limb ischemia. To this end, we hypothesize that the "adaptive inflammatory microenvironment" is pertinent to the cell-based regeneration, and make a brief comment on it based upon recent evidence.
authors: Department of Cardiology & Molecular Imaging Program; Xijing Hospital; Fourth Military Medical University; Xi'an, PR China.
authors: Weiwei
authors: W
authors: Fan
authors: Jibin
authors: J
authors: Zhang
authors: Zheng
authors: Z
authors: Zhang
authors: Qiong
authors: Q
authors: Wang
authors: Feng
authors: F
authors: Cao
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation; D051379:Mice; D009203:Myocardial Infarction / Q000628:therapy*; D012038:Regeneration; D055153:Stem Cell Niche; D057905:Stem Cell Research; D033581:Stem Cell Transplantation; D023822:Tissue Engineering
keywords: cell transplantation; endogenous cardiac regeneration; inflammatory microenvironment; ischemic cardiovascular disease; tissue regeneration
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