title: Immunological functioning in Alzheimer's disease: differential effects of relative left versus right temporoparietal dysfunction.
abstract: The cerebral hemispheres are differentially involved in regulating immunological functioning and the neuropathology associated with Alzheimer's disease (AD) is asymmetrical. Thus, subgroups of AD patients may exhibit different patterns of immunological dysfunction. We explored this possibility in a group of AD patients and found that patients with low white blood cell counts and low lymphocyte numbers exhibited better performance on tests of right temporoparietal functioning. Also, a significant positive relationship exists between lymph numbers and performance on a test of left temporoparietal functioning. Thus, some AD patients have greater immunological dysfunction based on relative left versus right temporoparietal functioning.
authors: Middle Tennessee State University, Psychology Department, Murfreesboro, TN 37132, United States; Murfreesboro Medical Clinic, Medical Center Parkway, Murfreesboro, TN, United States; University of Florida, Neurology Department, Gainesville, FL 32608, United States. Electronic address: paul.foster@mtsu.edu.
authors: Paul S
authors: PS
authors: Foster
authors: Katelyn M
authors: KM
authors: Roosa
authors: Megan R
authors: MR
authors: Williams
authors: John C
authors: JC
authors: Witt
authors: Kenneth M
authors: KM
authors: Heilman
authors: Valeria
authors: V
authors: Drago
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000276:immunology* / Q000473:pathology*; D010775:Photic Stimulation / Q000379:methods; D013702:Temporal Lobe / Q000276:immunology* / Q000473:pathology*
keywords: Alzheimer's disease; Immunological functioning; Neuropsychological