title: Making scent of the presence and local translation of odorant receptor mRNAs in olfactory axons.
abstract: Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections.
authors: Université Pierre et Marie Curie Paris 06 (UPMC), Unité Mixte de Recherche (UMR) 7102, Team Development and Plasticity of Neural Network, UMR 7102, F-75005, Paris, France; Centre National de la Recherche Scientifique, UMR 7102, F-75005, Paris, France.
authors: Caroline
authors: C
authors: Dubacq
authors: Coralie
authors: C
authors: Fouquet
authors: Alain
authors: A
authors: Trembleau
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D009830:Olfactory Bulb / Q000502:physiology; D009833:Olfactory Pathways / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger
keywords: axon guidance; local translation; mouse; odorant receptor; olfactory system
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