title: Neutralizing antibodies associated with exposure factors to Orthopoxvirus in laboratory workers.
abstract: Extensive use of Vaccinia virus (VACV) in research has led to associated accidental human exposure in laboratories worldwide. In spite of the social and economic relevance of Bovine Vaccinia outbreaks in Brazil, national data concerning laboratory workers handling these infectious agents are relatively scarce. Therefore, a serological survey was conducted in a Brazilian laboratory to evaluate staff exposure to orthopoxviruses (OPVs). Information concerning direct work with OPVs, vaccination status and laboratory accidents was collected and correlated to serology results. This study presents an opportunity for discussion of routine procedures involving OPVs in laboratories and their intrinsic risks. Aspects of the live attenuated smallpox vaccine are also discussed.
authors: Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, n° 6627, Pampulha, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil.
authors: Galileu Barbosa
authors: GB
authors: Costa
authors: Elizabeth Castro
authors: EC
authors: Moreno
authors: Giliane
authors: G
authors: de Souza Trindade
mesh_terms: D000328:Adult; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil; D002417:Cattle; D005260:Female; D006801:Humans; D007753:Laboratories; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D018155:Orthopoxvirus / Q000276:immunology*; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral
keywords: Occupational infection; Serological survey; Vaccinia virus