title: A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting.
abstract: A novel and general strategy is developed to design selective artificial enzyme inhibitor based on nanoparticleenzyme inter actions and molecular imprinting. Due to the creation of specific binding cavities, the resulting artificial inhibitor has high inhibition efficiency for the target enzyme, and shows great target-selectivity over other enzymes of similar function and proteins of compaable mole cular weight.
authors: The Key Lab of Analysis Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350108, P. R. China.
authors: Cheng
authors: C
authors: Zheng
authors: Xiao-Long
authors: XL
authors: Zhang
authors: Wei
authors: W
authors: Liu
authors: Bo
authors: B
authors: Liu
authors: Huang-Hao
authors: HH
authors: Yang
authors: Zi-An
authors: ZA
authors: Lin
authors: Guo-Nan
authors: GN
authors: Chen
mesh_terms: D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D015195:Drug Design; D008958:Models, Molecular; D008968:Molecular Conformation; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D037742:Nanotubes, Carbon; D011108:Polymers; D011480:Protease Inhibitors; D002918:Chymotrypsin; C117608:alpha-chymotrypsin
keywords: enzyme inhibitor; molecular imprinted polymers; molecular recognition; nanoparticles