title: Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration.
abstract: Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.
authors: Institute for Frontier Materials, Deakin University, Geelong, Australia.
authors: Dolly
authors: D
authors: Mushahary
authors: Ragamouni
authors: R
authors: Sravanthi
authors: Yuncang
authors: Y
authors: Li
authors: Mahesh J
authors: MJ
authors: Kumar
authors: Nemani
authors: N
authors: Harishankar
authors: Peter D
authors: PD
authors: Hodgson
authors: Cuie
authors: C
authors: Wen
authors: Gopal
authors: G
authors: Pande
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D005269:Femur / Q000187:drug effects / Q000502:physiology / Q000601:surgery; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008297:Male; D008422:Materials Testing; D008673:Metals, Alkaline Earth / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects*; D019736:Prostheses and Implants; D011817:Rabbits; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000497:Alloys; D018786:Bone Substitutes; D008673:Metals, Alkaline Earth; D015040:Zirconium
keywords: bone mineralization; corrosion; osseointegration; osteoblasts; peri-implant; surface energy
references: Acta Biomater. 2012 Jul;8(6):2360-74
references: 22387336
references: J Periodontol. 2009 Feb;80(2):210-8
references: 19186960
references: J Biomed Mater Res A. 2007 Jun 1;81(3):748-56
references: 17390368
references: J Biomed Mater Res A. 2011 Apr;97(1):27-36
references: 21308982
references: Acta Biomater. 2010 May;6(5):1680-92
references: 20172057
references: Clin Oral Implants Res. 2011 May;22(5):512-7
references: 21143533
references: Int J Oral Maxillofac Implants. 1993;8(3):264-72
references: 8225461
references: J Biomed Mater Res B Appl Biomater. 2012 May;100(4):911-23
references: 22287336
references: Acta Biomater. 2013 Nov;9(10):8548-60
references: 22922249
references: Biomed Eng Online. 2012 Mar 20;11:14
references: 22429539
references: Acta Biomater. 2011 Jan;7(1):432-40
references: 20804867
references: Colloids Surf B Biointerfaces. 2011 Nov 1;88(1):254-9
references: 21783346
references: J Biomed Mater Res A. 2009 Sep 1;90(3):882-93
references: 18618719
references: J Biomed Mater Res B Appl Biomater. 2012 Aug;100(6):1524-34
references: 22689410
references: Acta Biomater. 2010 May;6(5):1861-8
references: 20035905
references: Biomaterials. 2008 Apr;29(12):1776-84
references: 18222536
references: Biomaterials. 2008 Apr;29(10):1329-44
references: 18191191
references: J Dent Educ. 2003 Aug;67(8):932-49
references: 12959168
references: Head Face Med. 2008 Nov 06;4:25
references: 18990214
references: Eur Cell Mater. 2012 Apr 10;23:273-86; discussion 286-8
references: 22492019
references: Clin Oral Implants Res. 2010 Nov;21(11):1278-87
references: 20497442
references: J Mater Sci Mater Med. 2010 Apr;21(4):1091-8
references: 20020186
references: J Biomed Mater Res A. 2012 May;100(5):1168-78
references: 22337701
references: Acta Biomater. 2012 Aug;8(8):3177-88
references: 22531570
references: Clin Oral Implants Res. 2009 May;20(5):433-40
references: 19522974
references: J Inorg Biochem. 1997 Apr;66(1):1-6
references: 9076968
references: J Biomed Mater Res A. 2009 Jun;89(3):717-26
references: 18449935
references: Int J Periodontics Restorative Dent. 2008 Apr;28(2):123-35
references: 18546808
references: Biomaterials. 2006 Mar;27(9):1728-34
references: 16246414
references: J Mater Sci Mater Med. 2012 Mar;23(3):805-12
references: 22190200
references: Biomaterials. 2008 Jul;29(20):2941-53
references: 18440630
references: Biomaterials. 2006 Jun;27(16):3096-108
references: 16460797
references: Exp Cell Res. 1995 Jan;216(1):35-45
references: 7813631
references: Acta Biomater. 2012 Mar;8(3):1230-8
references: 22107870
references: Bull N Y Acad Med. 1972 Feb;48(2):257-72
references: 4500643