title: Modeling myocardial growth and hypertrophy in engineered heart muscle.
abstract: The introduction of biomimetic culture paradigms has advanced myocardial tissue engineering fundamentally, enabling today the provision of engineered rodent and human heart muscle with features characteristically found in postnatal myocardium. This is in marked contrasts to "flat" cardiomyocyte cultures with their typically low degree of organotypic maturation. Here, we discuss the collagen hydrogel-based engineered heart muscle (EHM) technology and provide background information on its use in simulations of myocardial growth and disease.
authors: Institute of Pharmacology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner site Göttingen, Göttingen, Germany.
authors: Malte
authors: M
authors: Tiburcy
authors: Institute of Pharmacology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner site Göttingen, Göttingen, Germany. Electronic address: w.zimmermann@med.uni-goettingen.de.
authors: Wolfram-Hubertus
authors: WH
authors: Zimmermann
mesh_terms: D000818:Animals; D032701:Biomimetics; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology*; D018929:Cell Culture Techniques; D049109:Cell Proliferation; D048430:Cell Shape; D003094:Collagen / Q000378:metabolism; D006801:Humans; D020100:Hydrogels; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D020100:Hydrogels; D003094:Collagen