title: Neonatal disorders of germinal matrix.
abstract: The germinal matrix (GM) is a richly vascularized, transient layer near the ventricles. It produces neurons and glial cells, and is present in the foetal brain between 8 and 36 weeks of gestation. At 25 weeks, it reaches its maximum volume and subsequently withers. The GM is vulnerable to haemorrhage in preterm infants. This selective vulnerability is explained by limited astrocyte end-feet coverage of microvessels, reduced expression of fibronectin and immature tight junctions. Focal lesions in the neonatal period include haemorrhage, germinolysis and stroke. Such lesions in transient layers interrupt normal brain maturation and induce neurodevelopmental sequelae.
authors: a Department of Neonatology .
authors: M M A
authors: MM
authors: Raets
authors: a Department of Neonatology .|b Department of Radiology .|c Department of Neuroscience , and.
authors: J
authors: J
authors: Dudink
authors: a Department of Neonatology .|d Department of Pediatrics , ZNA Paola Children's Hospital , Antwerp , Belgium.
authors: P
authors: P
authors: Govaert
mesh_terms: D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000098:blood supply* / Q000196:embryology* / Q000254:growth & development; D005353:Fibronectins / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D020300:Intracranial Hemorrhages / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D055806:Microvessels / Q000473:pathology; D019108:Tight Junctions / Q000473:pathology
chemical_list: D005353:Fibronectins
keywords: Germinal matrix; germinolysis; haemorrhage; neonatal