title: Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
abstract: To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Daniel
authors: D
authors: Chubb
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors: Niels
authors: N
authors: Weinhold
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Peter
authors: P
authors: Broderick
authors: German Cancer Research Center, Heidelberg, Germany.
authors: Bowang
authors: B
authors: Chen
authors: Haemato-Oncology, Division of Pathology, Institute of Cancer Research, Surrey, UK.
authors: David C
authors: DC
authors: Johnson
authors: German Cancer Research Center, Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors: Asta
authors: A
authors: Försti
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Jayaram
authors: J
authors: Vijayakrishnan
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Gabriele
authors: G
authors: Migliorini
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Sara E
authors: SE
authors: Dobbins
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Amy
authors: A
authors: Holroyd
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.|National Centre of Tumour Diseases, Heidelberg, Germany.
authors: Dirk
authors: D
authors: Hose
authors: Haemato-Oncology, Division of Pathology, Institute of Cancer Research, Surrey, UK.
authors: Brian A
authors: BA
authors: Walker
authors: Haemato-Oncology, Division of Pathology, Institute of Cancer Research, Surrey, UK.
authors: Faith E
authors: FE
authors: Davies
authors: University of Leeds, Leeds, UK.
authors: Walter A
authors: WA
authors: Gregory
authors: Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors: Graham H
authors: GH
authors: Jackson
authors: Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
authors: Julie A
authors: JA
authors: Irving
authors: Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK.
authors: Guy
authors: G
authors: Pratt
authors: Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK.
authors: Chris
authors: C
authors: Fegan
authors: Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors: James Al
authors: JA
authors: Fenton
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors: Kai
authors: K
authors: Neben
authors: Institute of Human Genetics, University of Bonn, Germany.|Department of Genomics, University of Bonn, Germany.
authors: Per
authors: P
authors: Hoffmann
authors: Institute of Human Genetics, University of Bonn, Germany.|Department of Genomics, University of Bonn, Germany.|German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
authors: Markus M
authors: MM
authors: Nöthen
authors: Institute of Human Genetics, University of Bonn, Germany.|Department of Genomics, University of Bonn, Germany.
authors: Thomas W
authors: TW
authors: Mühleisen
authors: Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Germany.
authors: Lewin
authors: L
authors: Eisele
authors: Cytogenetics Group, Wessex Regional Cytogenetic Laboratory, Salisbury, UK.
authors: Fiona M
authors: FM
authors: Ross
authors: Schön Klinik Starnberger See, Berg, Germany.
authors: Christian
authors: C
authors: Straka
authors: University Clinic of Würzburg, Würzburg, Germany.
authors: Hermann
authors: H
authors: Einsele
authors: Department of Internal Medicine III, University of Ulm, Ulm, Germany.
authors: Christian
authors: C
authors: Langer
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
authors: Elisabeth
authors: E
authors: Dörner
authors: Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle-upon-Tyne, UK.
authors: James M
authors: JM
authors: Allan
authors: Institute of Human Genetics, University of Heidelberg, Germany.
authors: Anna
authors: A
authors: Jauch
authors: Haemato-Oncology, Division of Pathology, Institute of Cancer Research, Surrey, UK.
authors: Gareth J
authors: GJ
authors: Morgan
authors: German Cancer Research Center, Heidelberg, Germany.|Center for Primary Health Care Research, Lund University, Malmo, Sweden.
authors: Kari
authors: K
authors: Hemminki
authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
authors: Richard S
authors: RS
authors: Houlston
authors: Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.|National Centre of Tumour Diseases, Heidelberg, Germany.
authors: Hartmut
authors: H
authors: Goldschmidt
mesh_terms: D016022:Case-Control Studies; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D020022:Genetic Predisposition to Disease; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*
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