title: Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii L. and coriandrum sativum L. as periodontal drug delivery.
abstract: BACKGROUND
  Periodontitis is inflammation of the supporting tissues of the teeth caused by specific microorganisms. Intra-periodontal pocket, mucoadhesive drug delivery systems have been shown to be clinically effective in the treatment of periodontitis. The aim of this study was to formulate a mucoadhesive gel from the seed hull of Quercus brantii and fruits of Coriandrum sativum for the treatment of periodontitis.
  
  
  METHODS
  The semisolid concentrated extracts were incorporated in gel base. Mucoadhesive gels were prepared using carbopol 940, sodium carboxymethylcellulose (sodium CMC) and hydroxypropyl methylcellulose K4M (HPMC) as bioadhesive polymers. Physicochemical tests, mucoadhesive strength measurement and in vitro drug release study were carried out on two formulations containing carbopol 940 and sodium CMC polymers (Formulations F4 and F5). We investigated the antibacterial activity of formulation F5 against Porphyromonas gingivalis using the disk diffusion method on supplemented Brucella agar.
  
  
  RESULTS
  Eight gel formulations were prepared. Physical appearance, homogeneity and consistency of F4 and F5 were good. Mucoadhesion and viscosity of F5 (1% carbopol 940 and 3% sodium CMC) was more than F4 (0.5% carbopol 940 and 3% sodium CMC). Drug release from F5 was slower. Both of formulations were syringeable through 21 G needle. In the disk diffusion method, F5 produced significant growth inhibition zones against P. gingivalis.
  
  
  CONCLUSIONS
  The ideal formulation for the treatment of periodontitis should exhibit high value of mucoadhesion, show controlled release of drug and be easily delivered into the periodontal pocket preferably using a syringe. Based on in vitro release and mucoadhesion studies, F5 was selected as the best formulation.
authors: Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Abolfazl
authors: A
authors: Aslani
authors: Alireza
authors: A
authors: Ghannadi
authors: Hajar
authors: H
authors: Najafi
keywords: Coriandrum sativum; Quercus brantii; herbal gel; periodontal drug delivery; polyphenol
references: J Clin Gastroenterol. 2007 Oct;41(9):834-8
references: 17881930
references: J Dent. 2009 Jun;37(6):413-23
references: 19303186
references: Pak J Biol Sci. 2010 Jun 1;13(11):537-45
references: 21848067
references: AAPS PharmSciTech. 2009;10(3):716-23
references: 19479385
references: Am J Clin Nutr. 2005 Jan;81(1 Suppl):215S-217S
references: 15640483
references: Eur J Pharm Biopharm. 2000 Jul;50(1):83-99
references: 10840194
references: J Adv Pharm Technol Res. 2012 Jan;3(1):9-15
references: 22470888
references: Evid Based Complement Alternat Med. 2012;2012:632796
references: 22203875
references: Arch Pharm Res. 2007 Jul;30(7):871-5
references: 17703740
references: J Control Release. 2000 Jul 3;67(2-3):357-68
references: 10825567
references: Eur J Pharm Biopharm. 2002 Sep;54(2):135-41
references: 12191683
references: Indian J Pharm Sci. 2010 Nov;72(6):710-8
references: 21969742
references: J Ethnopharmacol. 2002 Apr;80(1):21-4
references: 11891083
references: Molecules. 2009 Dec 01;14(12):4987-5000
references: 20032872
references: Chem Pharm Bull (Tokyo). 2002 Jan;50(1):40-6
references: 11824583