title: [The microbiology and antimicrobial susceptibility of the infected knee arthroplasty].
abstract: OBJECTIVE
  To describe the microbiology, antimicrobial susceptibility of patients proven prosthetic joint infection (PJI) after primary total knee arthroplasty (TKA)and to provide reference for the diagnosis and treatment of this complication.
  
  
  METHODS
  The medical data of the patients with infected knee arthroplasty, who were managed with revision surgery between January 1995 to December 2011 were reviewed. Twenty-nine cases were identified and majority of the patients were female (23/29). Diagnosis of PJI after primary TKA was between 1 week and 10 years (average 24.3 months). The microbiology and antimicrobial susceptibility were analyzed.
  
  
  RESULTS
  The overall positive rate of cultures was 65.5% (19/29). The most common organisms identified were Coagulase-negative Staphylococcus (CNS) (7/19) and Staphylococcus Aureus (SA) (5/19). Rare pathogens of Mycobacterium (2/19) and fungi (1/19) were also identified. Vancomycin was the most effective antibiotics with overall sensitivity rates of 100%.Resistant and rare pathogens were all in type IV infection.
  
  
  CONCLUSIONS
  Gram-positive bacterias are the main pathogen, resistant and rare pathogens should be payed attention to. Antibiotic treatment for infected TKA should be based on the results of drug susceptibility. Vancomycin allows infected knee arthroplasties before the result.
authors: Department of Orthopedics, Peking Union Medical Collage Hospital, Peking Union Medical Collage, Chinese Academy of Medical Science, Beijing 100730, China.
authors: Hui-ming
authors: HM
authors: Peng
authors: Xi-sheng
authors: XS
authors: Weng
authors: Ji-liang
authors: JL
authors: Zhai
authors: Yan-yan
authors: YY
authors: Bian
authors: Jin
authors: J
authors: Lin
authors: Jin
authors: J
authors: Jin
authors: Wen-wei
authors: WW
authors: Qian
authors: Li-juang
authors: LJ
authors: Zhao
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019645:Arthroplasty, Replacement, Knee; D024881:Drug Resistance, Bacterial; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin