title: miR-128 and its target genes in tumorigenesis and metastasis.
abstract: MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis.
authors: Dalian Medical University, Dalian 116044, China. Electronic address: molin_li@hotmail.com.
authors: Molin
authors: M
authors: Li
authors: Weiming
authors: W
authors: Fu
authors: Lulu
authors: L
authors: Wo
authors: Xiaohong
authors: X
authors: Shu
authors: Fang
authors: F
authors: Liu
authors: Chuangang
authors: C
authors: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D063646:Carcinogenesis / Q000235:genetics*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C545189:MIRN128 microRNA, human; D035683:MicroRNAs; C550324:Mirn128 microRNA, mouse
keywords: Metastasis; MicroRNA-128 (miR-128); Target genes; Tumorigenesis