title: Botulinum toxin type A in children and adolescents with severe cerebral palsy: a retrospective chart review.
abstract: This retrospective cohort study reviewed set goals and their outcomes of children and adolescents with severe cerebral palsy who received botulinum toxin A in 2008 and 2009. Sixty children (36 male, mean age 9 years) were included. They received on average 4 (range 1-7) treatments, with the dosage varying between 20 and 400 units per treatment (3-21 U/kg/body weight). Mild transient side effects were reported in 12 of 242 treatments with botulinum toxin A. Treatment goals were related to lower limb function (82%), range of motion (68%), positioning (33%), upper limb function (33%), and facilitating ease of care in dressing (30%), toileting, and diapering (22%). The treatment goals were reached in 60% to 85% by report of the parent and child dyad. Our findings suggest that botulinum toxin A should be considered as a treatment option in patients with cerebral palsy within Gross Motor Function Classification System levels IV and V.
authors: 1McMaster University, Hamilton, Ontario, Canada.
authors: Ronit
authors: R
authors: Mesterman
authors: Jan Willem
authors: JW
authors: Gorter
authors: Adrienne
authors: A
authors: Harvey
authors: Julia
authors: J
authors: Lockhart
authors: Jenny
authors: J
authors: McEwen-Hill
authors: Karen
authors: K
authors: Margallo
authors: Nancy
authors: N
authors: Goldie
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D035002:Lower Extremity; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012648:Self Care; D012720:Severity of Illness Index; D016896:Treatment Outcome; D034941:Upper Extremity
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A
keywords: botulinum toxin A; cerebral palsy; children; hypertonia treatment; outcome