title: Changes induces by haloperidol (antidepressant drug) on the developing retina of the chick embryo.
abstract: Morphological and histological studies were done on the retina of chick embryos of 6th, 10th and 16th days of incubation by a single dose of haloperidol (0.25 mg/egg), injected on day zero and 5 of incubation. To get an idea about the extent of the teratogenic effect of this drug on the development retina. Sign of malformation in the chick embryo after administration of haloperidol were seen as absent of the ear vesicles, eyes or decreased size of them. Retardation of growth of the retina at 6th, 10th and 16th days treated chick embryo were observed as evidenced of reduction of the size of the retina, associated with sign of degeneration of the retina cells.
  
  
  CONCLUSIONS
  The injection of haloperidol drug give rise to several side effects as retardation of growth and degeneration of the cells. The decrease of the thickness of the layers and less density of the cells was related to direct effect of the drug on the cells of this organ. Also on the DNA formation and on the retardation of cellular mitotic activates, therefore the retina appeared decrease in thickness and less cell density with degeneration its cells.
authors: Department of Zoology (Embryology), Girls College of Education in Jeddah, King Abdul-Aziz University, Saudi Arabia.
authors: Badria Fathy
authors: BF
authors: Abd-Elmagid
authors: Fawzyah Abdullah
authors: FA
authors: Al-Ghamdi
keywords: Chick embryo; Degeneration; Haloperidol; Retardation; Retina; Toxicity
references: Brain Res Bull. 1992 Sep-Oct;29(3-4):449-58
references: 1356601
references: Neuropharmacology. 1981 Dec;20(12B):1243-9
references: 7033814
references: Eur J Neurosci. 2003 Apr;17(8):1563-70
references: 12752374
references: Pharmacol Biochem Behav. 1989 Dec;34(4):721-5
references: 2533691
references: Neurochem Res. 1982 Sep;7(9):1059-74
references: 6129583
references: Indian J Exp Biol. 1997 Sep;35(9):1014-5
references: 9475081
references: Cell Mol Neurobiol. 1990 Jun;10(2):281-9
references: 2364411
references: Pharmacol Res. 2006 Nov;54(5):361-72
references: 16962336
references: Neurochem Int. 2007 Jun;50(7-8):976-82
references: 17092607
references: Prog Brain Res. 1988;73:509-22
references: 2901780
references: Ann Clin Psychiatry. 1999 Dec;11(4):237-56
references: 10596739
references: Brain Res. 2008 Feb 27;1196:53-8
references: 18234163
references: Neuropathol Appl Neurobiol. 1982 Mar-Apr;8(2):109-16
references: 7099384
references: Brain Res. 1977 Jul 1;129(2):299-308
references: 884506
references: Behav Brain Funct. 2006 Nov 29;2:37
references: 17132176
references: Teratology. 1994 Aug;50(2):125-36
references: 7801300
references: Prog Brain Res. 1988;73:389-403
references: 3047804
references: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):633-42
references: 18055082