title: [PROK1, prognostic marker of embryo implantation?].
abstract: In spite of improvements in assisted reproductive technology (ART) during the last 30 years, the rate of pregnancy remains constrained, as only about 25 % of embryo transfer lead to successful pregnancies, even with an average of two embryos replaced. Embryo selection is currently based on the establishment of morphokinetic scores, a method that obviously exhibits limitations. Therefore, the assessment of embryo development potency by criteria of higher predictive value is mandatory in order to increase the rates of pregnancy. Nowadays, there is increasing evidence that angiogenic factors might contribute to the success of the implantation and to the pregnancy outcome. Among these factors, prokineticin 1 (PROK1) and its receptors (PROKRs) constitute new targets that showed over the last ten years strong biological features directly linked to ovarian physiology, endometrial receptivity, embryo implantation and thus successful pregnancies. In ART, the rates of circulating PROK1 were reported in 2012 as significantly linked to the quality of embryonic cohort, as well as to the rates of pregnancy. Our preliminary data suggest a high potential of this cytokine in the success of implantation and pregnancy, and strongly overtones the emergency to investigate the value of its measurement in conditioned media of oocytes and embryo cultures in ART.
authors: Centre d'aide médicale à la procréation, CHU de Grenoble, hôpital Couple-Enfant, CS 10217, 38043 Grenoble cedex 9, France. sbrouillet@chu-grenoble.fr
authors: S
authors: S
authors: Brouillet
authors: P
authors: P
authors: Hoffmann
authors: C
authors: C
authors: Thomas-Cadi
authors: U
authors: U
authors: Bergues
authors: J-J
authors: JJ
authors: Feige
authors: N
authors: N
authors: Alfaidy
authors: S
authors: S
authors: Hennebicq
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000737:chemistry; D046149:Embryo Culture Techniques; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D009865:Oocytes / Q000378:metabolism; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted; D016896:Treatment Outcome; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived / Q000032:analysis / Q000097:blood* / Q000502:physiology
chemical_list: D015415:Biomarkers; D017077:Culture Media, Conditioned; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
keywords: Assistance médicale à la procréation; Assisted reproductive technology; Biomarker; Biomarqueur; EG-VEGF; Implantation; Prokineticin; Prokinéticines