title: Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man.
abstract: Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.
authors: Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, N15, W7 Kita-Ku, Sapporo, Hokkaido, Japan, takakenta@med.hokudai.ac.jp.
authors: Kenta
authors: K
authors: Takahashi
authors: Masumi
authors: M
authors: Tsuda
authors: Hiromi
authors: H
authors: Kanno
authors: Junichi
authors: J
authors: Murata
authors: Roshan
authors: R
authors: Mahabir
authors: Yusuke
authors: Y
authors: Ishida
authors: Taichi
authors: T
authors: Kimura
authors: Mishie
authors: M
authors: Tanino
authors: Hiroshi
authors: H
authors: Nishihara
authors: Kazuo
authors: K
authors: Nagashima
authors: Shinya
authors: S
authors: Tanaka
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005909:Glioblastoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008297:Male; D009154:Mutation; D009837:Oligodendroglioma / Q000175:diagnosis / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human