title: MicroRNAs as novel regulators of neuroinflammation.
abstract: MicroRNAs are relatively recently discovered class of small noncoding RNAs, which function as important regulators of gene expression. They fine-tune protein expression either by translational inhibition or mRNA degradation. MicroRNAs act as regulators of diverse cellular processes, such as cell differentiation, proliferation, and apoptosis. Their defective biogenesis or function has been identified in various pathological conditions, like inflammation, neurodegeneration, or autoimmunity. Multiple sclerosis is one of the predominated debilitating neurological diseases affecting mainly young adults. It is a multifactorial disorder of as yet unknown aetiology. As far, it is suggested that interplay between genetic and environmental factors is responsible for MS pathogenesis. The role of microRNAs in this pathology is now extensively studied. Here, we want to review the current knowledge of microRNAs role in multiple sclerosis.
authors: Department of Neurology, Epileptology and Stroke, Medical University of Lodz, Zeromskiego Street 113, 90-549 Lodz, Poland. ksiazekdominika@gmail.com
authors: Dominika Justyna
authors: DJ
authors: Ksiazek-Winiarek
authors: Magdalena Justyna
authors: MJ
authors: Kacperska
authors: Andrzej
authors: A
authors: Glabinski
mesh_terms: D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity; D002454:Cell Differentiation; D049109:Cell Proliferation; D002490:Central Nervous System / Q000473:pathology; D015894:Genome, Human; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D035683:MicroRNAs / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D022661:RNA, Untranslated / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated
references: Nat Struct Mol Biol. 2006 Dec;13(12):1097-101
references: 17099701
references: Mol Cell. 2008 May 23;30(4):460-71
references: 18498749
references: Curr Drug Targets. 2010 Aug;11(8):943-9
references: 20415654
references: Cell. 2008 Mar 7;132(5):860-74
references: 18329371
references: Immunity. 2007 Dec;27(6):847-59
references: 18055230
references: Front Biosci (Elite Ed). 2012 Jan 01;4(4):1478-95
references: 22201969
references: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5282-7
references: 19289835
references: J Biol Chem. 2008 Nov 14;283(46):31315-22
references: 18801740
references: Cell. 2005 Dec 2;123(5):819-31
references: 16325577
references: Cell. 2007 Oct 5;131(1):146-59
references: 17923094
references: Cell. 2009 Feb 20;136(4):642-55
references: 19239886
references: Plant Cell Physiol. 2008 Apr;49(4):493-500
references: 18344228
references: Neurobiol Dis. 2010 Jan;37(1):13-25
references: 19664713
references: Cell. 2010 Sep 17;142(6):914-29
references: 20850013
references: Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7080-5
references: 17438277
references: Immunology. 2012 Jan;135(1):73-88
references: 22043967
references: Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39
references: 19165215
references: J Neuroinflammation. 2010 Oct 15;7:68
references: 20946687
references: Brain. 2005 Jul;128(Pt 7):1667-76
references: 15800022
references: Genome Res. 2009 Jan;19(1):92-105
references: 18955434
references: Diabetes. 2012 Aug;61(8):1986-93
references: 22688341
references: Shock. 2008 Sep;30(3):260-6
references: 18197146
references: J Exp Med. 2008 Sep 29;205(10):2199-206
references: 18762567
references: PLoS One. 2012;7(9):e44789
references: 23028621
references: Adv Immunol. 1977;25:1-54
references: 345773
references: J Neurosci Res. 2007 Jun;85(8):1694-703
references: 17465018
references: Mol Cell. 2007 Jul 6;27(1):91-105
references: 17612493
references: J Exp Med. 1997 Jul 21;186(2):307-12
references: 9221760
references: Science. 2007 Apr 27;316(5824):604-8
references: 17463289
references: Cell Mol Immunol. 2011 Sep;8(5):380-7
references: 21822298
references: Autoimmun Rev. 2009 May;8(6):506-9
references: 19211042
references: Nat Struct Mol Biol. 2010 Aug;17(8):1030-4
references: 20622877
references: J Neurosci. 2003 Jan 1;23(1):223-9
references: 12514219
references: J Exp Med. 1996 Jul 1;184(1):61-9
references: 8691150
references: J Neuroimmunol. 1998 Oct 1;90(2):113-21
references: 9817438
references: Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8
references: 21383194
references: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2735-40
references: 19193853
references: Nature. 2008 Oct 23;455(7216):1124-8
references: 18806776
references: Science. 2007 Apr 27;316(5824):608-11
references: 17463290
references: Nat Immunol. 2009 May;10(5):514-23
references: 19305396
references: Semin Immunol. 1998 Oct;10(5):351-3
references: 9799709
references: Nat Med. 2011 Jan;17(1):64-70
references: 21131957
references: Fluids Barriers CNS. 2011 Jan 18;8(1):4
references: 21349152
references: Lancet. 2008 Oct 25;372(9648):1502-17
references: 18970977
references: Transplantation. 2010 Jul 27;90(2):105-12
references: 20574417
references: Cell. 2006 Jun 2;125(5):887-901
references: 16751099
references: Glia. 2011 Dec;59(12):1911-22
references: 22170100
references: Nat Med. 2005 Feb;11(2):146-52
references: 15665833
references: Adv Exp Med Biol. 2002;513:87-113
references: 12575818
references: EMBO Mol Med. 2012 Jan;4(1):3-14
references: 22162462
references: Lancet Neurol. 2008 Mar;7(3):268-77
references: 18275928
references: J Neurosci Res. 2005 Jul 1;81(1):45-52
references: 15952173
references: Nat Immunol. 2009 Dec;10(12):1252-9
references: 19838199
references: Cell. 2008 Mar 7;132(5):875-86
references: 18329372
references: Evid Based Complement Alternat Med. 2011;2011:984965
references: 19622601
references: Cancer Res. 2005 May 1;65(9):3509-12
references: 15867338
references: Reprod Biol Endocrinol. 2009 Feb 11;7:13
references: 19210773
references: Cell. 2012 Apr 27;149(3):515-24
references: 22541426
references: Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1248-57
references: 22517757
references: Nat Immunol. 2010 Nov;11(11):1057-62
references: 20935646
references: Nature. 2011 Aug 10;476(7359):214-9
references: 21833088
references: Semin Immunopathol. 2009 Nov;31(4):497-511
references: 19779720
references: Curr Opin Cell Biol. 2008 Apr;20(2):214-21
references: 18329869
references: Med Hypotheses. 2012 Mar;78(3):398-401
references: 22209051
references: Brain. 2009 May;132(Pt 5):1175-89
references: 19339255
references: J Neuroimmunol. 2010 Aug 25;225(1-2):5-12
references: 20537409
references: Nature. 2005 Jun 2;435(7042):590-7
references: 15931211
references: Curr Pharm Biotechnol. 2009 Sep;10(6):569-78
references: 19619125
references: J Clin Invest. 2010 May;120(5):1368-79
references: 20440079
references: Genes Dev. 2006 Mar 1;20(5):515-24
references: 16510870
references: Science. 2004 Jan 2;303(5654):83-6
references: 14657504
references: J Immunol. 2006 Jul 1;177(1):566-73
references: 16785554
references: Nat Rev Immunol. 2010 Feb;10(2):111-22
references: 20098459
references: N Engl J Med. 2003 Jul 10;349(2):139-45
references: 12853586
references: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21629-34
references: 21098294
references: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19849-54
references: 18056638
references: Autoimmunity. 2010 Nov;43(7):504-13
references: 20380590
references: J Neuroimmunol. 2010 Apr 15;221(1-2):7-14
references: 19931190
references: Blood. 2009 Jul 9;114(2):404-14
references: 19398721
references: Immunity. 2008 May;28(5):621-9
references: 18450484
references: Mol Neurobiol. 2009 Oct;40(2):139-56
references: 19629762
references: Cell. 2006 Feb 24;124(4):783-801
references: 16497588
references: Trends Biochem Sci. 2008 Dec;33(12):583-91
references: 18848452
references: Mol Immunol. 2009 Mar;46(6):1222-8
references: 19118902
references: Nat Cell Biol. 2007 Jul;9(7):775-87
references: 17589498
references: Cell. 2009 Jan 23;136(2):215-33
references: 19167326
references: J Neurosci Res. 2005 Aug 1;81(3):374-89
references: 15959904
references: J Clin Invest. 2004 Mar;113(6):788-94
references: 15067307
references: Acta Neuropathol. 2010 Jan;119(1):89-105
references: 20012873
references: Cell. 2007 Apr 6;129(1):147-61
references: 17382377
references: Neurology. 2004 Dec 28;63(12):2381-3
references: 15623705
references: Nat Rev Neurosci. 2001 Jul;2(7):502-11
references: 11433375
references: Nature. 2008 Feb 28;451(7182):1125-9
references: 18278031
references: Brain. 2009 Dec;132(Pt 12):3342-52
references: 19952055
references: Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17719-24
references: 17965236
references: Nat Rev Immunol. 2002 Dec;2(12):933-44
references: 12461566
references: J Neuropathol Exp Neurol. 2008 Dec;67(12):1113-21
references: 19018243
references: Science. 2007 Dec 21;318(5858):1931-4
references: 18048652
references: Immunity. 2008 May;28(5):630-8
references: 18455451
references: J Exp Med. 2001 Apr 2;193(7):855-62
references: 11283158
references: Brain Res. 2008 Aug 21;1226:234-40
references: 18602376
references: PLoS One. 2007 Jul 11;2(7):e610
references: 17622355
references: J Neuroimmune Pharmacol. 2010 Jun;5(2):189-97
references: 20107924
references: Trends Immunol. 2007 Jan;28(1):12-8
references: 17129764
references: Eur J Immunol. 2009 Jun;39(6):1608-18
references: 19408243
references: Brain. 2002 Oct;125(Pt 10):2202-12
references: 12244078
references: J Immunol. 2009 Mar 1;182(5):2578-82
references: 19234151
references: Immunity. 2010 Oct 29;33(4):607-19
references: 20888269
references: J Neuroimmunol. 2003 Sep;142(1-2):47-57
references: 14512163
references: Nature. 2008 Jun 19;453(7198):1051-7
references: 18563156
references: Genome Biol. 2005;6(8):R71
references: 16086853
references: Nature. 2007 May 24;447(7143):396-8
references: 17522671
references: Nucleic Acids Res. 2010 Nov;38(20):7248-59
references: 20615901
references: Int Rev Immunol. 2009;28(6):535-61
references: 19954362
references: Cardiovasc Res. 2008 Sep 1;79(4):551-2
references: 18614548
references: Neuromolecular Med. 2005;7(3):217-28
references: 16247182
references: Autoimmun Rev. 2012 Mar;11(5):305-14
references: 20627134
references: Nature. 2004 Nov 11;432(7014):235-40
references: 15531877
references: Trends Immunol. 2005 Sep;26(9):485-95
references: 16039904
references: PLoS One. 2010 Aug 11;5(8):e12132
references: 20711463
references: Front Neurosci. 2012 Apr 09;6:48
references: 22509148
references: Am J Pathol. 2006 Apr;168(4):1200-9
references: 16565495
references: Nature. 2008 Sep 4;455(7209):64-71
references: 18668037
references: Nat Immunol. 2010 Sep;11(9):799-805
references: 20711193
references: Immunol Rev. 1999 Jun;169:225-39
references: 10450520
references: EMBO Rep. 2009 Feb;10(2):180-5
references: 19098714
references: Autoimmune Dis. 2010 Nov 11;2011:807426
references: 21188194
references: Front Biosci (Schol Ed). 2010 Jun 01;2(3):1113-26
references: 20515844
references: RNA Biol. 2010 Sep-Oct;7(5):606-14
references: 20864815
references: Ann Neurol. 2007 Nov;62(5):504-14
references: 17879969
references: Brain Behav Immun. 2008 Feb;22(2):140-7
references: 17920811
references: Brain. 2009 Dec;132(Pt 12):3329-41
references: 19933767
references: J Immunol. 2010 Jul 15;185(2):990-7
references: 20548023
references: Cell Immunol. 2002 May-Jun;217(1-2):78-86
references: 12426003
references: Ann Rheum Dis. 2011 Mar;70 Suppl 1:i88-91
references: 21339227
references: J Exp Med. 2000 Aug 7;192(3):393-404
references: 10934227
references: Cell. 2006 Sep 22;126(6):1121-33
references: 16990136