title: Sex influences the effect of body mass index on the vascular response to angiotensin II in humans.
abstract: OBJECTIVE
  Sex influences the cardiorenal risk associated with body mass index (BMI). The role of the renin-angiotensin-aldosterone system in adiposity-mediated cardiorenal risk profiles in healthy, non-obese men and women was investigated.
  
  
  METHODS
  Systemic and renal hemodynamic responses to angiotensin-II (AngII) as a function of BMI, waist and hip circumference, waist-hip ratio, as well as fat and lean mass were measured in 18 men and 25 women in high-salt balance, stratified by BMI (<25 kg/m2 (ideal body weight (IBW)) vs. ≥25 kg/m2 overweight)).
  
  
  RESULTS
  In men (n = 7, BMI 23 ± 1 kg/m2) and women (n = 14, BMI 22 ± 2 kg/m2) of IBW, BMI was not associated with the systolic blood pressure (SBP) response to AngII. In contrast, overweight men (n = 11, 29 ± 2 kg/m2) demonstrated a progressively more blunted vasoconstrictor SBP response to AngII challenge as BMI increased (P = 0.007), even after adjustment for covariates. Women maintained the same relationship between BMI and the SBP response to AngII irrespective of weight status (P = 0.2, IBW vs. overweight women). Compared to BMI, other adiposity measures showed similar associations to systemic AngII responsiveness in men but not in women. Increasing BMI was associated with a blunted renovasoconstrictor response to AngII in all subjects, but was more pronounced in men.
  
  
  CONCLUSIONS
  Sex influences the effect of adiposity on vascular angiotensin-responsiveness.
authors: Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute of Alberta, Alberta, Canada.
authors: A A
authors: AA
authors: Zalucky
authors: D D M
authors: DD
authors: Nicholl
authors: M C
authors: MC
authors: Mann
authors: B R
authors: BR
authors: Hemmelgarn
authors: T C
authors: TC
authors: Turin
authors: J M
authors: JM
authors: Macrae
authors: D Y
authors: DY
authors: Sola
authors: S B
authors: SB
authors: Ahmed
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000652:urine; D050177:Overweight / Q000097:blood / Q000652:urine; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012307:Risk Factors; D012737:Sex Factors; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D012982:Sodium, Dietary; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D012964:Sodium; D003404:Creatinine