title: New approaches to control infections: anti-biofilm strategies against gram-negative bacteria.
abstract: Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.
authors: University of Konstanz, Department of Chemistry and Zukunftskolleg, Universitätsstrasse 10, D-78457 Konstanz.
authors: Roman
authors: R
authors: Sommer
authors: Ines
authors: I
authors: Joachim
authors: Stefanie
authors: S
authors: Wagner
authors: Alexander
authors: A
authors: Titz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents