title: Differential effects of electrical stimulation of the central amygdala and lateral hypothalamus on fos-immunoreactive neurons in the gustatory brainstem and taste reactivity behaviors in conscious rats.
abstract: Projections from the central amygdala (CeA) and lateral hypothalamus (LH) modulate the activity of gustatory brainstem neurons, however, the role of these projections in gustatory behaviors is unclear. The goal of the current study was to determine the effects of electrical stimulation of the CeA or LH on unconditioned taste reactivity (TR) behaviors in response to intra-oral infusion of tastants. In conscious rats, electrical stimulation of the CeA or LH was delivered with and without simultaneous intra-oral infusion of taste solutions via an intra-oral cannula. Immunohistochemistry for the Fos protein was used to identify neurons in the gustatory brainstem activated by the electrical and/or intra-oral stimulation. In the absence of intra-oral infusion of a tastant, electrical stimulation of either the CeA or the LH increased the number of ingestive, but not aversive, TR behaviors performed. During intra-oral infusions of taste solutions, CeA stimulation tended to increase aversive behaviors whereas LH stimulation dramatically reduced the number of aversive responses to quinine hydrochloride (QHCl). These data indicate that projections from the CeA and LH alter TR behaviors. A few of the behavioral effects were accompanied by changes in the number of Fos-immunoreactive neurons in the gustatory brainstem, suggesting a possible anatomical substrate for these effects.
authors: Department of Biology Department, Unit 8264, Stetson University, 421 North Woodland Boulevard, DeLand, FL 32723, USA. mking@stetson.edu.
authors: Christopher A
authors: CA
authors: Riley
authors: Michael S
authors: MS
authors: King
mesh_terms: D000679:Amygdala / Q000502:physiology* / Q000648:ultrastructure; D000818:Animals; D001522:Behavior, Animal; D003243:Consciousness; D004558:Electric Stimulation; D007031:Hypothalamus / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D009474:Neurons / Q000166:cytology*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D055697:Taste Perception
chemical_list: D016760:Proto-Oncogene Proteins c-fos
keywords: gustation; nucleus of the solitary tract; oromotor behavior; parabrachial nucleus; reticular formation
references: J Neurophysiol. 2004 Mar;91(3):1143-57
references: 14627662
references: J Comp Neurol. 1976 Mar 1;166(1):17-30
references: 1262547
references: Brain Res Bull. 1993;30(1-2):163-72
references: 7678381
references: Chem Senses. 2003 Feb;28(2):155-71
references: 12588737
references: Brain Res Brain Res Rev. 1997 Dec;25(3):276-90
references: 9495559
references: Brain. 1977 Jun;100(2):264-86
references: 884485
references: Chem Senses. 2007 Jul;32(6):543-55
references: 17488743
references: Physiol Behav. 1986;36(5):829-34
references: 3714857
references: Neuroreport. 1993 Sep 10;4(11):1223-6
references: 8219018
references: Science. 1965 Dec 3;150(3701):1320-1
references: 5857003
references: Trends Neurosci. 1989 Nov;12(11):459-62
references: 2479148
references: Brain Res. 1980 Sep 22;197(2):291-317
references: 7407557
references: Brain Res. 1978 Mar 24;143(2):263-79
references: 630409
references: Am J Physiol. 1999 Aug;277(2):R384-94
references: 10444544
references: Brain Res Brain Res Rev. 1997 Dec;25(3):291-311
references: 9495560
references: J Comp Neurol. 2000 Jul 3;422(3):429-47
references: 10861518
references: Brain Res. 1996 Mar 4;711(1-2):125-37
references: 8680855
references: Brain Res. 1970 Jun 30;21(1):63-77
references: 5433117
references: J Comp Neurol. 1983 Nov 1;220(3):280-98
references: 6315785
references: J Neurophysiol. 2001 Feb;85(2):770-83
references: 11160511
references: J Neurophysiol. 2002 Apr;87(4):1981-92
references: 11929917
references: J Comp Neurol. 1988 Oct 22;276(4):547-72
references: 2461969
references: Neurobiology (Bp). 1996;4(1-2):85-102
references: 9116697
references: Exp Brain Res. 2000 Jan;130(1):78-92
references: 10638444
references: Brain Res. 1984 Aug;319(3):229-59
references: 6478256
references: Neurosci Lett. 1987 Oct 16;81(1-2):95-9
references: 2447527
references: Brain Res. 1975 Jun 20;91(1):99-117
references: 1131704
references: Neurosci Biobehav Rev. 2000 Mar;24(2):173-98
references: 10714382
references: J Comp Neurol. 1983 Apr 10;215(3):290-8
references: 6304157
references: Neuroscience. 2002;115(4):1139-51
references: 12453486
references: J Comp Neurol. 1993 Mar 8;329(2):201-29
references: 8454730
references: Behav Neurosci. 1988 Dec;102(6):942-52
references: 2850815
references: J Comp Neurol. 1990 Nov 22;301(4):554-74
references: 2177063
references: J Neurophysiol. 2005 Mar;93(3):1183-96
references: 15483060
references: J Comp Neurol. 1990 Mar 22;293(4):540-80
references: 1691748
references: Neuroscience. 1991;40(3):735-58
references: 2062440
references: Brain Res. 1978 Mar 24;143(2):281-97
references: 630410
references: Brain Res. 2007 Apr 13;1141:188-96
references: 17276421
references: Physiol Behav. 1994 Dec;56(6):1197-202
references: 7878091
references: Neurosci Biobehav Rev. 1997 Sep;21(5):631-47
references: 9353796
references: J Neurophysiol. 2010 Aug;104(2):726-41
references: 20519577
references: J Neurosci. 1984 May;4(5):1201-7
references: 6726325
references: Brain Res. 1999 Mar 13;821(2):251-62
references: 10064811
references: Brain Res. 1987 Dec 22;437(1):142-50
references: 3427474
references: J Comp Neurol. 1992 Mar 1;317(1):57-78
references: 1374087
references: Physiol Behav. 1982 Jul;29(1):17-21
references: 7122727
references: Neuron. 1990 Apr;4(4):477-85
references: 1969743
references: J Comp Neurol. 1984 Mar 20;224(1):1-24
references: 6715573
references: J Neurosci. 1992 Sep;12(9):3582-90
references: 1527597
references: Brain Res. 1988 Aug 2;457(1):1-11
references: 3167557
references: Chem Senses. 2013 Oct;38(8):705-17
references: 23978688
references: Neurosci Lett. 1981 Jul 2;24(2):111-6
references: 6166908
references: Ann N Y Acad Sci. 1998 Nov 30;855:482-5
references: 9929642
references: J Comp Neurol. 1990 May 22;295(4):624-61
references: 1694187
references: Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R52-7
references: 17989138
references: Brain Res. 1999 Jan 23;816(2):364-74
references: 9878830
references: Behav Neurosci. 2004 Feb;118(1):163-72
references: 14979793
references: J Neurosci Methods. 1989 Sep;29(3):261-5
references: 2507830
references: Brain Res. 2001 Jun 15;904(1):54-66
references: 11516411
references: Cell Tissue Res. 1996 Mar;283(3):367-74
references: 8593666
references: Behav Neurosci. 2003 Dec;117(6):1423-33
references: 14674860
references: J Neurophysiol. 2002 Dec;88(6):2979-92
references: 12466423
references: Neuroscience. 1992 Sep;50(2):403-25
references: 1279462
references: Brain Res Brain Res Rev. 1997 Dec;25(3):255-75
references: 9495558
references: Neurosci Biobehav Rev. 2008 Oct;32(8):1601-6
references: 18675299
references: J Neurophysiol. 2004 Jul;92(1):265-79
references: 14973323
references: Brain Res. 1998 Dec 7;813(2):283-302
references: 9838165
references: Brain Res Bull. 1982 May;8(5):511-26
references: 6811106
references: Behav Brain Res. 1997 Nov;88(2):275-9
references: 9404636
references: Neuroscience. 1996 May;72(1):185-97
references: 8730716
references: Science. 1978 Nov 3;202(4367):537-9
references: 705344
references: J Neurosci. 1999 Apr 15;19(8):3107-21
references: 10191326
references: Brain Res. 1991 Aug 23;557(1-2):265-79
references: 1747757
references: Am J Physiol Regul Integr Comp Physiol. 2002 Jun;282(6):R1798-810
references: 12010763
references: J Neurosci. 1997 May 15;17(10):3826-39
references: 9133401