title: Chronic pancreatitis: a path to pancreatic cancer.
abstract: Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells.
authors: Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia.
authors: Andreia V
authors: AV
authors: Pinho
authors: Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; Macarthur Cancer Therapy Centre, Campbelltown Hospital, Campbelltown, Australia.
authors: Lorraine
authors: L
authors: Chantrill
authors: Cancer Research Program, The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia; St. Vincent's Clinical School, University of New South Wales, Sydney, Australia; Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: i.rooman@garvan.org.au.
authors: Ilse
authors: I
authors: Rooman
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D018836:Inflammation Mediators
keywords: Acinar to ductal metaplasia; Dedifferentiation; Inflammation; Oxidative stress; Pancreatic cancer; Pancreatitis