title: The role of nesfatin-1 in the regulation of food intake and body weight: recent developments and future endeavors.
abstract: Nesfatin-1 was discovered in 2006 and introduced as a potential novel anorexigenic modulator of food intake and body weight. The past years have witnessed increasing evidence establishing nesfatin-1 as a potent physiological inhibitor of food intake and body weight and unravelled nesfatin-1's interaction with other brain transmitters to exert its food consumption inhibitory effect. As observed for other anorexigenic brain neuropeptides, nesfatin-1 is also likely to exert additional, if not pleiotropic, actions in the brain and periphery. Recent studies established the prominent expression of the nesfatin-1 precursor, nucleobindin2 (NUCB2), in the stomach and pancreas, where nesfatin-1 influences endocrine secretion. This review will highlight the current experimental state-of-knowledge on the effects of NUCB2/nesfatin-1 on food intake, body weight and glucose homeostasis. Potential implications in human obesity will be discussed in relation to the evidence of changes in circulating levels of NUCB2/nesfatin-1 in disease states, the occurrence of genetic NUCB2 polymorphisms and--in contrast to several other hormones--the independence of leptin signalling known to be blunted under conditions of chronically increased body weight.
authors: Charité Center for Internal Medicine and Dermatology, Division for General Internal and Psychosomatic Medicine, Charité- Universitätsmedizin Berlin, Berlin, Germany.
authors: A
authors: A
authors: Stengel
authors: M
authors: M
authors: Mori
authors: Y
authors: Y
authors: Taché
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005544:Forecasting / Q000379:methods; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D000080866:Nucleobindins; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D020738:Leptin; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Food intake; NUCB2; hypothalamus; nesfatin-1
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