title: Increases in creatine kinase with atorvastatin treatment are not associated with decreases in muscular performance.
abstract: BACKGROUND
  The present study examined if increases in creatine kinase (CK) levels during high-dose atorvastatin treatment are associated with changes in skeletal muscle function and symptoms.
  
  
  METHODS
  The Effect of Statins on Muscle Performance study (STOMP) investigated the effects of atorvastatin 80 mg daily for 6 months on muscle performance, exercise capacity, and the incidence of statin-associated muscle complaints in healthy adults.
  
  
  RESULTS
  CK levels increased with atorvastatin (n = 202) from 132.3 ± 120.9 U/L (mean ± SD) at baseline to 159.7 ± 170.4 and 153.1 ± 139.4 U/L at 3 and 6 months, respectively (P ≤ 0.002 for both). Changes in CK with atorvastatin treatment were not associated with changes in muscle function or the incidence of myalgia. More subjects on atorvastatin (n = 24) compared to placebo (n = 12 of 217) doubled their CK level at 6 months (P = 0.02). No differences in muscle function or physical activity were observed between atorvastatin-treated subjects who did or did not double their CK.
  
  
  CONCLUSIONS
  Results of the present investigation extend the findings of STOMP by demonstrating that greater increases in CK levels with high-dose atorvastatin treatment did not deleteriously impact skeletal muscle function or predict skeletal muscle complaints. This study was registered at ClinicalTrials.gov (NCT00609063).
authors: Division of Cardiology, Henry Low Heart Center, Hartford Hospital, CT 06102, USA. kballard@harthosp.org
authors: Kevin D
authors: KD
authors: Ballard
authors: Beth A
authors: BA
authors: Parker
authors: Jeffrey A
authors: JA
authors: Capizzi
authors: Adam S
authors: AS
authors: Grimaldi
authors: Priscilla M
authors: PM
authors: Clarkson
authors: Stephanie M
authors: SM
authors: Cole
authors: Justin
authors: J
authors: Keadle
authors: Stuart
authors: S
authors: Chipkin
authors: Linda S
authors: LS
authors: Pescatello
authors: Kathleen
authors: K
authors: Simpson
authors: C Michael
authors: CM
authors: White
authors: Paul D
authors: PD
authors: Thompson
mesh_terms: D000328:Adult; D000069059:Atorvastatin; D003402:Creatine Kinase / Q000378:metabolism*; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects* / Q000737:chemistry; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology*; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D063806:Myalgia / Q000139:chemically induced; D011758:Pyrroles / Q000009:adverse effects* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D003402:Creatine Kinase
keywords: Exercise; Muscle; Myalgia; Statins
references: Ann Clin Biochem. 1988 Jul;25 ( Pt 4):389-91
references: 3214120
references: Circulation. 2013 Jan 1;127(1):96-103
references: 23183941
references: Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):58-63
references: 12524225
references: Am J Cardiol. 2012 Jan 15;109(2):282-7
references: 22036108
references: Am J Cardiol. 1993 Nov 1;72(14):1031-7
references: 8213583
references: N Engl J Med. 2011 Dec 15;365(24):2250-1
references: 22085320
references: J Appl Physiol (1985). 2005 Aug;99(2):564-9
references: 15817725
references: CMAJ. 2009 Jul 7;181(1-2):E11-8
references: 19581603
references: J Appl Physiol (1985). 2010 Jun;108(6):1651-8
references: 20339010
references: Atherosclerosis. 2010 Jun;210(2):337-43
references: 20042189
references: Clin Rheumatol. 2000;19(4):296-300
references: 10941812
references: Am J Cardiol. 1994 Oct 1;74(7):667-73
references: 7942524
references: JAMA. 1998 May 27;279(20):1615-22
references: 9613910
references: Ann Intern Med. 2002 Oct 1;137(7):581-5
references: 12353945
references: Eur Heart J. 1999 Jan;20(1):58-69
references: 10075142
references: N Engl J Med. 2008 Nov 20;359(21):2195-207
references: 18997196
references: Am Heart J. 2014 Jul;168(1):6-15
references: 24952854
references: Arch Intern Med. 1993 Jun 14;153(11):1321-9
references: 8507122
references: Arch Intern Med. 1996 Oct 14;156(18):2085-92
references: 8862101
references: J Am Coll Cardiol. 1995 Nov 1;26(5):1133-9
references: 7594023
references: JAMA. 2002 Jun 26;287(24):3215-22
references: 12076217
references: Eur Heart J. 1994 Feb;15(2):255-69
references: 8005129
references: Metabolism. 1997 Oct;46(10):1206-10
references: 9322808
references: Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):51-4
references: 16433891