title: The correlation between gatifloxacin's acute adverse reaction and intravenous drip velocity.
abstract: OBJECTIVE
  To investigate the correlation between acute adverse reaction (AAR) and intravenous drip velocity of gatifloxacin.
  
  
  METHODS
  Patients who had received intravenous gatifloxacin (0.2g/100 ml) infusion in the Emergency Center, Zhongnan Hospital, Wuhan University, Wuhan, China from January to August 2012 were enrolled in this study. Patients were randomly divided into 3 groups according to different drip velocities: Group A: velocity ≤10 drops per minute; Group B: <10 velocity ≤20 drops per minute; Group C: <20 velocity ≤30 drops per minute. The AAR and demographic data of patients were documented.
  
  
  RESULTS
  Acute adverse reaction of the skin and digestive system were significantly positively related to intravenous drip velocity. The AAR of the cardiovascular system significantly increased when the intravenous drip velocity was beyond 20 drops per minute. The AAR of nervous system and abnormal glycometabolism has no significant correlation with intravenous drip velocity of gatifloxacin.
  
  
  CONCLUSIONS
  Acute adverse reactions of skin, digestive system, and cardiovascular system would decrease with an appropriate velocity of intravenous gatifloxacin (0.2g/100 ml) less than 10 drops per minute.
authors: Emergency Center, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China. Tel. +86 (027) 67813337. E-mail: jianjian_1998@sina.com.
authors: Jian
authors: J
authors: Xia
authors: Yan
authors: Y
authors: Zhao
authors: Hai-Hua
authors: HH
authors: Chen
authors: Jian
authors: J
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D000077734:Gatifloxacin; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin