title: Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin.
abstract: Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.
authors: University of Southern California, 1050 Childs Way, Los Angeles, CA, United States. Electronic address: chiolo@usc.edu.
authors: Irene
authors: I
authors: Chiolo
authors: Jonathan
authors: J
authors: Tang
authors: Walter
authors: W
authors: Georgescu
authors: Sylvain V
authors: SV
authors: Costes
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000528:radiation effects*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology; D022041:Euchromatin / Q000235:genetics / Q000528:radiation effects*; D006570:Heterochromatin / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D007700:Kinetics; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000473:pathology
chemical_list: D022041:Euchromatin; D006570:Heterochromatin
keywords: Biomarker; Cancer risk; Chromatin dynamics; DSB response; Ionizing radiation; Modeling
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