title: Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents.
abstract: Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg · kg(-1). In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg(-1)). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.
authors: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.
authors: Marco Antonio
authors: MA
authors: Costa
authors: João Carlos
authors: JC
authors: Palazzo de Mello
authors: Edílson Nobuyoshi
authors: EN
authors: Kaneshima
authors: Tânia
authors: T
authors: Ueda-Nakamura
authors: Benedito Prado
authors: BP
authors: Dias Filho
authors: Elisabeth Aparecida
authors: EA
authors: Audi
authors: Celso Vataru
authors: CV
authors: Nakamura
references: Environ Mol Mutagen. 2003;41(4):293-9
references: 12717784
references: Phytomedicine. 2004;11(4):352-60
references: 15185850
references: Clin Microbiol Infect. 2008 May;14 Suppl 4:65-70
references: 18430131
references: J Ethnopharmacol. 2008 Nov 20;120(2):141-8
references: 18762237
references: J Ethnopharmacol. 2002 Nov;83(1-2):101-4
references: 12413713
references: J Ethnopharmacol. 2007 Mar 1;110(1):76-91
references: 17056216
references: J Hepatol. 2009 Jan;50(1):80-8
references: 18977053
references: Biol Pharm Bull. 2006 Jun;29(6):1092-5
references: 16754999
references: Ann Clin Biochem. 2003 Sep;40(Pt 5):489-507
references: 14503986
references: Am J Reprod Immunol. 2007 Jan;57(1):2-12
references: 17156186
references: J Ethnopharmacol. 2004 Mar;91(1):43-50
references: 15036466
references: Ann Clin Microbiol Antimicrob. 2009 Nov 05;8:29
references: 19891776
references: Braz J Med Biol Res. 2000 Feb;33(2):179-89
references: 10657057
references: Toxicol Lett. 2003 Jun 5;143(1):55-63
references: 12697381
references: Mem Inst Oswaldo Cruz. 2005 Jul;100(4):397-401
references: 16113888
references: Regul Toxicol Pharmacol. 2010 Nov;58(2):330-5
references: 20655967
references: Toxicol Pathol. 2002 Jan-Feb;30(1):66-74
references: 11890477
references: J Toxicol Environ Health. 1986;18(2):161-88
references: 3712484
references: J Ethnopharmacol. 2011 Apr 12;134(3):992-5
references: 21291982
references: J Antimicrob Chemother. 2006 Nov;58(5):942-9
references: 16973655
references: Food Chem Toxicol. 2010 Feb;48(2):620-5
references: 19944127
references: J Ethnopharmacol. 2005 Jun 3;99(2):265-72
references: 15894137
references: Phytother Res. 1999 May;13(3):264-6
references: 10353177
references: Food Chem Toxicol. 2010 Jul;48(7):1817-20
references: 20398723
references: Trends Microbiol. 2003 Jun;11(6):272-9
references: 12823944