title: Application of proton magnetic resonance spectroscopy on substantia nigra metabolites in Parkinson's disease.
abstract: This study investigates changes in substantia nigra metabolites in Parkinson's disease (PD) using proton magnetic resonance spectroscopy ((1)H- MRS). Thirty patients with asymmetric PD and 20 normal controls were included in this study. Substantia nigra metabolites were detected in all subjects using 3D-multimer (1)H-MRS with a 3.0 T MRI scanner. The relative ratios of NAA/Cr, NAA/Cho, NAA/(Cho + Cr) in the substantia nigra were compared between two sides of asymmetric PD patients as well as between PD patients and controls. Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were observed between PD patients and healthy controls (P < 0.05) as well as between the ipsilateral and contralateral of affected extremity in PD patients (P < 0.05). Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were also observed between patients with mild and severe PD. Thus, we found that (1)H-MRS can be used to detect substantia nigra metabolites in PD patients, which may be useful for early diagnosis and evaluation of PD.
authors: Department of Radiology, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
authors: Bing
authors: B
authors: Zhou
authors: Fangzhen
authors: F
authors: Yuan
authors: Zhong
authors: Z
authors: He
authors: Changlian
authors: C
authors: Tan
mesh_terms: D000328:Adult; D000368:Aged; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D011522:Protons; D013378:Substantia Nigra / Q000378:metabolism*
chemical_list: D004151:Dipeptides; D011522:Protons; C027172:isospaglumic acid; D003401:Creatine; D002794:Choline