title: Clathrin-independent endocytosis: a cargo-centric view.
abstract: Clathrin-independent endocytosis occurs in all cells and interest in this mode of cellular entry has grown. Although this form of endocytosis was first described for entry of bacterial toxins, here we focus our attention on the endogenous cell surface "cargo" proteins that enter cells by this mechanism. The cargo proteins entering by this mechanism are varied and include nutrient transporters, ion channels, cell adhesion molecules and proteins associated with the immune system. Despite the apparent lack of selection at the cell surface, we provide some examples of specific sorting of these cargo proteins after entry, leading to distinct itineraries and cellular fates.
authors: Cell Biology & Physiology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
authors: Lymarie
authors: L
authors: Maldonado-Báez
authors: Chad
authors: C
authors: Williamson
authors: Julie G
authors: JG
authors: Donaldson
mesh_terms: D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis / Q000276:immunology / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D002966:Clathrin
keywords: Cell adhesion molecules; Clathrin-independent endocytosis; Endocytosis; Ion channels; Nutrient transporters; Plasma membrane protein; Protein sorting
references: Mol Biol Cell. 2012 May;23(10):1874-88
references: 22456504
references: Mol Cell. 2001 Mar;7(3):661-71
references: 11463390
references: Cell. 2002 Sep 20;110(6):673-87
references: 12297042
references: J Cell Biol. 2013 Apr 15;201(2):233-47
references: 23589492
references: Traffic. 2008 Sep;9(9):1446-57
references: 18564371
references: J Clin Invest. 1998 Apr 15;101(8):1708-16
references: 9541502
references: Int J Cancer. 1990 Jan 15;45(1):59-68
references: 2404879
references: Dev Cell. 2008 Aug;15(2):209-19
references: 18694561
references: J Cell Sci. 2004 Jan 26;117(Pt 3):373-80
references: 14702383
references: J Biol Chem. 2000 Mar 17;275(11):7964-74
references: 10713114
references: Nat Cell Biol. 2006 Jan;8(1):46-54
references: 16341206
references: J Biol Chem. 1999 Apr 16;274(16):11408-16
references: 10196234
references: Cell Signal. 2009 Jan;21(1):1-6
references: 18647649
references: Proc Natl Acad Sci U S A. 1991 May 1;88(9):3598-602
references: 1673787
references: J Biol Chem. 2003 Jun 27;278(26):23672-7
references: 12716892
references: Nat Cell Biol. 2007 Sep;9(9):1066-73
references: 17704769
references: Curr Biol. 2007 Nov 20;17(22):1913-24
references: 17997305
references: Eur J Immunol. 1989 Jan;19(1):1-8
references: 2465900
references: J Cell Biol. 1988 Aug;107(2):743-51
references: 2971068
references: Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21354-9
references: 23223633
references: Mol Cell Biol. 2013 Apr;33(8):1503-14
references: 23382078
references: J Cell Biol. 1994 Jul;126(2):317-30
references: 8034737
references: Cell. 2004 Feb 6;116(3):445-56
references: 15016378
references: J Biol Chem. 2009 Feb 6;284(6):3577-85
references: 19033440
references: Nat Rev Mol Cell Biol. 2009 Sep;10(9):597-608
references: 19696797
references: Prog Mol Biol Transl Sci. 2013;116:409-32
references: 23481205
references: IUBMB Life. 2010 May;62(5):315-33
references: 20209635
references: Mol Biol Cell. 2003 Feb;14(2):417-31
references: 12589044
references: J Cell Sci. 2008 Jul 1;121(Pt 13):2136-47
references: 18544637
references: J Biol Chem. 2003 Jun 6;278(23):21050-7
references: 12657640
references: Am J Hum Genet. 2010 Jun 11;86(6):872-80
references: 20560207
references: Nat Immunol. 2013 May;14(5):500-8
references: 23525088
references: J Cell Biol. 1997 Oct 6;139(1):49-61
references: 9314528
references: Mol Cell. 2010 Feb 12;37(3):370-82
references: 20159556
references: Clin Cancer Res. 2009 Dec 15;15(24):7462-7468
references: 20008845
references: J Biol Chem. 2005 May 20;280(20):19656-64
references: 15749704
references: Nat Rev Mol Cell Biol. 2003 May;4(5):409-14
references: 12728274
references: J Cell Sci. 2012 Apr 15;125(Pt 8):1991-2003
references: 22328521
references: Nat Cell Biol. 2008 Jan;10(1):30-41
references: 18084285
references: Mol Biol Cell. 2006 Jan;17(1):163-77
references: 16251358
references: Mol Immunol. 2007 Jan;44(1-3):73-81
references: 16884774
references: Mol Biol Cell. 2004 Aug;15(8):3542-52
references: 15146059
references: J Cell Sci. 2012 Mar 15;125(Pt 6):1373-82
references: 22499670
references: Traffic. 2007 Oct;8(10):1404-14
references: 17662026
references: J Cell Biol. 2010 Aug 23;190(4):675-91
references: 20713605
references: J Biol Chem. 2000 Feb 18;275(7):5059-64
references: 10671548
references: Immunobiology. 2012 Nov;217(11):1080-7
references: 22964233
references: Nat Cell Biol. 2013 May;15(5):461-71
references: 23563491
references: J Cell Biol. 1994 Jul;126(2):391-401
references: 7518464
references: Pharmacol Ther. 2009 Jan;121(1):29-40
references: 18992769
references: Dev Cell. 2011 Jun 14;20(6):751-63
references: 21664574
references: Cardiovasc Drugs Ther. 2011 Oct;25(5):379-91
references: 21805404
references: J Cell Biol. 2007 Aug 13;178(4):701-11
references: 17682053
references: Dev Cell. 2005 Sep;9(3):377-88
references: 16139226
references: J Clin Invest. 1989 Jun;83(6):2008-17
references: 2566624
references: Annu Rev Biochem. 2001;70:503-33
references: 11395416
references: Dev Cell. 2002 Apr;2(4):411-23
references: 11970892
references: Nature. 2011 Nov 09;480(7378):534-7
references: 22080952
references: Mol Biol Cell. 2004 Aug;15(8):3758-70
references: 15181155
references: Cell Mol Life Sci. 2012 Sep;69(18):3015-26
references: 22460579
references: Mol Biol Cell. 2007 Apr;18(4):1272-81
references: 17267690
references: Methods Enzymol. 2005;404:422-31
references: 16413288
references: J Biol Chem. 2008 May 23;283(21):14717-27
references: 18378669
references: Cell. 1987 Dec 4;51(5):813-9
references: 3315233
references: Histochem Cell Biol. 2008 Mar;129(3):267-76
references: 18193449
references: Proc Natl Acad Sci U S A. 2001 May 22;98(11):6360-5
references: 11353871
references: Cell. 1990 Jun 29;61(7):1303-13
references: 1694723
references: Cardiol Res Pract. 2012;2012:632408
references: 22454776
references: J Cell Sci. 2003 Apr 15;116(Pt 8):1599-609
references: 12640043
references: Nature. 2009 Mar 26;458(7237):445-52
references: 19325624
references: EMBO J. 2000 Aug 1;19(15):3896-904
references: 10921872
references: Cell. 1989 Mar 10;56(5):849-53
references: 2538244
references: Nat Rev Mol Cell Biol. 2003 Jan;4(1):33-45
references: 12511867
references: Cell. 1989 Mar 10;56(5):839-47
references: 2538243
references: J Biol Chem. 1998 Sep 11;273(37):23629-32
references: 9726963
references: Biochim Biophys Acta. 2008 Oct;1780(10):1087-92
references: 18625289
references: Connect Tissue Res. 2008;49(3):175-9
references: 18661337
references: J Virol. 2012 May;86(9):4868-82
references: 22345471
references: Annu Rev Cell Dev Biol. 2007;23:519-47
references: 17506697
references: J Cell Sci. 2009 Apr 1;122(Pt 7):912-8
references: 19258392
references: J Biol Chem. 2006 Nov 10;281(45):34601-9
references: 16945930
references: Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15470-5
references: 15494436
references: Ther Deliv. 2013 Mar;4(3):281-4
references: 23442072
references: J Dermatol Sci. 2011 Mar;61(3):169-79
references: 21282044
references: Blood. 1992 Jun 1;79(11):2807-20
references: 1586732
references: Traffic. 2011 Jan;12(1):102-20
references: 20961375
references: J Cell Biol. 2001 Mar 5;152(5):923-34
references: 11238449
references: J Cell Biol. 2001 Sep 3;154(5):1007-17
references: 11535619
references: Biochem J. 2000 Nov 1;351 Pt 3:607-12
references: 11042114
references: J Biol Chem. 1997 Nov 14;272(46):29174-80
references: 9360995
references: J Immunol. 2011 May 1;186(9):5021-3
references: 21505213
references: Nat Rev Mol Cell Biol. 2001 Feb;2(2):107-17
references: 11252952
references: Dev Cell. 2013 Mar 11;24(5):472-85
references: 23453597
references: Nature. 1998 Sep 17;395(6699):288-91
references: 9751058
references: Mol Biol Cell. 2006 Feb;17(2):645-57
references: 16314390
references: J Cell Biol. 1994 Jan;124(1-2):71-82
references: 7507492
references: Nat Rev Mol Cell Biol. 2009 Sep;10(9):583-96
references: 19696796
references: Nature. 2003 Mar 6;422(6927):37-44
references: 12621426
references: J Virol. 2013 Jun;87(12):6866-75
references: 23576506
references: Mol Biol Cell. 2011 Sep;22(17):3218-30
references: 21757542
references: Lipids Health Dis. 2006 Aug 31;5:23
references: 16945147
references: Neuropharmacology. 2007 Jan;52(1):100-7
references: 16890965
references: J Biol Chem. 2009 Oct 30;284(44):30328-38
references: 19723633
references: Antimicrob Agents Chemother. 2010 Jul;54(7):2753-66
references: 20439611
references: Nucleic Acids Res. 1989 Mar 11;17(5):1915-31
references: 2928113
references: J Biol Chem. 2004 Mar 19;279(12):11112-8
references: 14707126
references: J Biol Chem. 2007 Apr 27;282(17):13087-97
references: 17331948
references: Brain Dev. 2009 Aug;31(7):545-52
references: 19304421
references: Traffic. 2004 Jan;5(1):20-36
references: 14675422
references: Traffic. 2008 Sep;9(10):1801-10
references: 18647170
references: Traffic. 2009 May;10(5):590-9
references: 19302270
references: J Virol. 2009 Nov;83(21):11064-77
references: 19710132
references: FEBS J. 2007 Jun;274(11):2715-27
references: 17451431
references: Nat Rev Mol Cell Biol. 2013 Feb;14(2):98-112
references: 23340574
references: Int J Biochem Cell Biol. 2007;39(3):505-28
references: 17097330