title: Rh(III)-catalyzed tandem C-H allylation and oxidative cyclization of anilides: a new entry to indoles.
abstract: Rh(III)-catalyzed tandem C-H allylation and oxidative cyclization of anilides with allyl carbonates in the presence of a slight excess of AgSbF6 salt and Cu(OAc)2 as oxidant affords easy, economical access to important bioactive 2-methylindoles. The new reaction supports a wide range of functional groups on the anilide substrate. A possible mechanism is proposed as a basis for its rational further development.
authors: Departamento de Química Orgánica y Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors: Ana
authors: A
authors: Cajaraville
authors: Susana
authors: S
authors: López
authors: Jesús A
authors: JA
authors: Varela
authors: Carlos
authors: C
authors: Saá
mesh_terms: D000813:Anilides / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000813:Anilides; D002254:Carbonates; D007211:Indoles; D012238:Rhodium; C022958:2-methylindole