title: [C-reactive protein prior to radical cystectomy: preoperative determination of CRP].
abstract: BACKGROUND
  Numerous studies have shown a positive correlation between elevated C-reactive protein (CRP) and systemic spread of malignancies. The goal of the current study was to assess the predictive significance of preoperative CRP in patients undergoing radical cystectomy (RC).
  
  
  METHODS
  Preoperative CRP values were measured in 194 patients undergoing RC because of urothelial carcinoma between 1996 and 2005. Elevated CRP level was defined as ≥ 5 mg/l.
  
  
  RESULTS
  Preoperative increased CRP values were detected in 89 (45.9%) patients and these patients were more likely to have advanced tumor stages (pT3-4), positive resection margins and positive lymph nodes. Advanced urinary diversions were more common in patients with normal CRP values. In multivariate analysis, CRP was identified as an independent prognostic indicator for poor cancer-specific survival.
  
  
  CONCLUSIONS
  The results confirm previous reports that showed a prognostic significance of preoperative CRP elevation.
authors: Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland.
authors: M W
authors: MW
authors: Kramer
authors: A
authors: A
authors: Heinisch
authors: G
authors: G
authors: Wegener
authors: M
authors: M
authors: Abbas
authors: C
authors: C
authors: von Klot
authors: I
authors: I
authors: Peters
authors: H
authors: H
authors: Tezval
authors: T R
authors: TR
authors: Herrmann
authors: M A
authors: MA
authors: Kuczyk
authors: A S
authors: AS
authors: Merseburger
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D015653:Cystectomy / Q000401:mortality*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000401:mortality* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein
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