title: First clinical manifestation of Brugada syndrome during pregnancy.
abstract: The role of hormonal changes during pregnancy in Brugada syndrome is unknown. Only rare case reports of Brugada syndrome during pregnancy have been published. In this article, we describe a patient with first clinical manifestation of Brugada syndrome during pregnancy. The definitive diagnosis could only be achieved by drug challenge with ajmaline after childbirth because the spontaneous typical Brugada-like pattern was absent. Elevated hormone levels during pregnancy may increase the risk for arrhythmias in particular cases.
authors: Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany. dirk.prochnau@med.uni-jena.de
authors: Dirk
authors: D
authors: Prochnau
authors: Hans R
authors: HR
authors: Figulla
authors: Ralf
authors: R
authors: Surber
mesh_terms: D000328:Adult; D000404:Ajmaline; D000889:Anti-Arrhythmia Agents; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000517:prevention & control*; D012640:Seizures / Q000175:diagnosis / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D000404:Ajmaline
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