title: Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins.
abstract: Protein post-translational modifications (PTMs) are central to the host innate immune regulations. Dynamically, PTMs fine-tune the spatial and temporary responses of immune- and non-immune-cells, in accordance with extracellular and intracellular stresses. Ubiquitin and ubiquitin-like proteins (Ubls) are emerging as the important multi-functional signals, controlling the activation, stability, affinity and location of many signaling proteins. Recent investigations, at the molecular-cellular-animal models, have shed new light on the versatility of the ubiquitin, SUMO and ISG15, for shaping the strength and duration of the innate immune responses. This review summarizes our current knowledge on the functions and regulatory mechanisms of the ubiquitin and Ubls in the innate immunity, the first line of host defense against microbial infection.
authors: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors: Xing
authors: X
authors: Liu
authors: Qiang
authors: Q
authors: Wang
authors: Wei
authors: W
authors: Chen
authors: Chen
authors: C
authors: Wang
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology; D018160:Receptors, Cytoplasmic and Nuclear / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology; D014452:Ubiquitins / Q000276:immunology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D014452:Ubiquitins
keywords: ISG15; Innate immunity; SUMO; Signal transduction; Ubiquitin