title: Association of HLA-DR/DQ polymorphism with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in Tunisian patients.
abstract: OBJECTIVE
  Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder of the peripheral nervous system (PNS). The aim of this study was to investigate associations between HLA-DR/DQ alleles and CIDP in Tunisian patients.
  
  
  METHODS
  HLA DR/DQ genotyping was performed using polymerase chain reaction sequence-specific primers (PCR-SSP) with 36 CIDP patients and 100 healthy individuals serving as the control group.
  
  
  RESULTS
  CIDP in Tunisian patients was found to be associated with the HLA-DRB1*13 allele (pc=0.03) (where pc denotes the Bonferroni corrected probability value). Moreover, the two haplotypes, DRB1*13/DQB1*06 (22.22% of patients vs. 8.5% of controls, pc=0.017) and DRB1*07/DQB1*03 (13.88% of patients vs. 3% of controls, pc=0.005), were found to confer a susceptibility to CIDP.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on CIDP susceptibility in a Tunisian population.
authors: Université Tunis el Manar, Faculté des Science de Tunis, El Manar, Tunisia; Hôpital Militaire Principal d'Instruction de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, 1008 Montfleury, Tunisia.
authors: Meriem
authors: M
authors: Mrad
authors: Najiba
authors: N
authors: Fekih-Mrissa
authors: Malek
authors: M
authors: Mansour
authors: Aicha
authors: A
authors: Seyah
authors: Anis
authors: A
authors: Riahi
authors: Nasreddine
authors: N
authors: Gritli
authors: Ridha
authors: R
authors: Mrissa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D021141:Nucleic Acid Amplification Techniques / Q000379:methods; D011110:Polymorphism, Genetic; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000235:genetics* / Q000276:immunology; D014416:Tunisia
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens
keywords: CIDP; HLA-DR/DQ polymorphism; PCR-SSP; Typing HLA