title: Sugar for the brain: the role of glucose in physiological and pathological brain function.
abstract: The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. We synthesize these findings to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation that lead to disease.
authors: Department of Experimental Neurology and Department of Neurology, Center for Stroke Research, NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Berlin, Germany. Electronic address: philipp.mergenthaler@charite.de.
authors: Philipp
authors: P
authors: Mergenthaler
authors: Ute
authors: U
authors: Lindauer
authors: Gerald A
authors: GA
authors: Dienel
authors: Andreas
authors: A
authors: Meisel
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans
chemical_list: D005947:Glucose
keywords: apoptosis; brain-body axis; glucose metabolism; metabolic brain disease; metabolic coupling
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