title: A let-7 KRAS rs712 polymorphism increases colorectal cancer risk.
abstract: Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer. We aimed to investigate the association between let-7 KRAS rs712 polymorphism and the risk of colorectal cancer (CRC). The let-7 KRAS rs712 was analyzed in a case-control study, including 339 CRC patients and 313 age- and sex-matched controls; the relationship between the polymorphism and the clinicopathological features of CRC was also examined. Individuals carrying the let-7 KRAS rs712 TT genotype and T allele had an increased risk of developing CRC (TT vs. GG, adjusted OR = 2.18; 95% CI, 1.00-4.77; T vs. G, adjusted OR = 1.50; 95% CI, 1.15-1.96). Stratified analyses revealed that CRC patients with the let-7 KRAS rs712 TT genotype were more likely to have clinical stage III or IV disease (OR = 3.29, 95% CI, 1.32-8.20) and distant metastasis (OR = 4.70, 95% CI, 1.81-12.25). These findings provide evidence that the let-7 KRAS rs712 polymorphism may play crucial roles in the etiology of CRC.
authors: Department of Forensic Pathology, College of Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, 471003, People's Republic of China, mitochondrium@126.com.
authors: Xin-Min
authors: XM
authors: Pan
authors: Rui-Fen
authors: RF
authors: Sun
authors: Zhao-Hui
authors: ZH
authors: Li
authors: Xiao-Min
authors: XM
authors: Guo
authors: Zhen
authors: Z
authors: Zhang
authors: Hao-Jie
authors: HJ
authors: Qin
authors: Guo-Hui
authors: GH
authors: Xu
authors: Lin-Bo
authors: LB
authors: Gao
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D012306:Risk; D047368:Tumor Burden; D018631:ras Proteins / Q000235:genetics*
chemical_list: C117307:KRAS protein, human; D035683:MicroRNAs; D011518:Proto-Oncogene Proteins; C487931:mirnlet7 microRNA, human; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
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