title: Comparing predictors of conversion to Alzheimer's disease using the disease state index.
abstract: BACKGROUND
  The Disease State Index (DSI) is a method which interprets data originating from multiple different sources, assisting the clinician in the diagnosis and follow-up of dementia diseases.
  
  
  OBJECTIVE
  We compared the differences in accuracy in differentiating stable mild cognitive impairment (S-MCI) and progressive MCI (P-MCI) obtained from different data combinations using the DSI.
  
  
  METHODS
  We investigated 212 cases with S-MCI and 165 cases with P-MCI from the Alzheimer's Disease Neuroimaging Initiative cohort. Data from neuropsychological tests, cerebrospinal fluid, apolipoprotein E (APOE) genotype, magnetic resonance imaging (MRI) and positron emission tomography (PET) were included.
  
  
  RESULTS
  The combination of all parameters gave the highest accuracy (accuracy 0.70, sensitivity 0.71, specificity 0.68). In the different categories, neuropsychological tests (0.65, 0.65, 0.65) and hippocampal volumetry (0.66, 0.66, 0.66) achieved the highest accuracy.
  
  
  CONCLUSIONS
  In addition to neuropsychological testing, MRI is recommended to be included for differentiating S-MCI from P-MCI. APOE genotype, CSF and PET may provide some additional information.
authors: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
authors: Miguel Ángel
authors: MÁ
authors: Muñoz-Ruiz
authors: Anette
authors: A
authors: Hall
authors: Jussi
authors: J
authors: Mattila
authors: Juha
authors: J
authors: Koikkalainen
authors: Sanna-Kaisa
authors: SK
authors: Herukka
authors: Ritva
authors: R
authors: Vanninen
authors: Yawu
authors: Y
authors: Liu
authors: Jyrki
authors: J
authors: Lötjönen
authors: Hilkka
authors: H
authors: Soininen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D015415:Biomarkers / Q000032:analysis*; D060825:Cognitive Dysfunction; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers