title: Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.
abstract: Plasmonic nanomaterials including gold nanorods are effective agents for inducing heating in tumors. Because near-infrared (NIR) light has traditionally been delivered using extracorporeal sources, most applications of plasmonic photothermal therapy have focused on isolated subcutaneous tumors. For more complex models of disease such as advanced ovarian cancer, one of the primary barriers to gold nanorod-based strategies is the adequate delivery of NIR light to tumors located at varying depths within the body. To address this limitation, a series of implanted NIR illumination sources are described for the specific heating of gold nanorod-containing tissues. Through computational modeling and ex vivo studies, a candidate device is identified and validated in a model of orthotopic ovarian cancer. As the therapeutic, imaging, and diagnostic applications of plasmonic nanomaterials progress, effective methods for NIR light delivery to challenging anatomical regions will complement ongoing efforts to advance plasmonic photothermal therapy toward clinical use.
authors: Koch Institute for Integrative Cancer Research, ¶Health Sciences and Technology, and #Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology , Cambridge, Massachusetts, United States.
authors: Alexander F
authors: AF
authors: Bagley
authors: Samuel
authors: S
authors: Hill
authors: Gary S
authors: GS
authors: Rogers
authors: Sangeeta N
authors: SN
authors: Bhatia
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods; D007259:Infrared Rays / Q000627:therapeutic use; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy*; D010789:Phototherapy / Q000295:instrumentation* / Q000379:methods; D019736:Prostheses and Implants; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D006046:Gold
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