title: Wound contraction decreases with intravenously injected substance P in rabbits.
abstract: Substance P is an injury-inducible endogenous factor for the mobilization of CD29+ stromal-like cells into circulation and that are major effectors of accelerated healing. In this study, we evaluated the effect of intravenously injected substance P on full-thickness skin wound healing as a secondary intention wound model. We made circular full-thickness skin wounds on the ears of 28 New Zealand white rabbits. They were treated with phosphate-buffered saline, or intravenous 5, 50, or 250 n mole/kg substance P at days 0 and 1. All substance P-treated groups showed a 2.6-5.4-fold higher CD29 expression and resulted in greatly decreased wound contraction and early maturation of the stroma. However, a significant decrease in wound contraction was measured only in the 5 n mole/kg treatment group. We conclude that intravenously injected substance P at 5 n mole/kg decreases wound contraction and promotes wound maturation in full-thickness skin wounds in a rabbit ear model.
authors: Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Gyeonggi-do, Republic of Korea.
authors: Jun Yong
authors: JY
authors: Lee
authors: Department of Plastic and Reconstructive Surgery & Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Electronic address: kimws@cau.ac.kr.
authors: Woo Seob
authors: WS
authors: Kim
authors: Department of Microbiology & Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors: Wonyong
authors: W
authors: Kim
authors: Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul, Republic of Korea.
authors: Han Koo
authors: HK
authors: Kim
authors: Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Seoul, Republic of Korea.
authors: Tae Hui
authors: TH
authors: Bae
authors: Department of Plastic and Reconstructive Surgery & Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors: Jeong Ae
authors: JA
authors: Park
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004423:Ear / Q000293:injuries*; D007275:Injections, Intravenous; D019012:Integrin beta1 / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000293:injuries; D017154:Stromal Cells / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D019012:Integrin beta1; D013373:Substance P
keywords: CD29; Substance P; Wound contraction; Wound healing