title: Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure.
abstract: BACKGROUND
  Anal fissure is a common benign condition. An anorectal problem is defined as a split in the anal canal mucosa that extends from the dentate line to the anal verge. Chronic anal fissure is defined by a history of symptoms present for more than 2 months' duration and with a triad of external skin tags, namely, a hypertrophied anal papilla, an ulcer with rolled edges, and a base exposing the internal sphincter. Because complications such as incontinence are associated with surgical treatment, chemical sphincterotomy is currently favored.
  
  
  OBJECTIVE
  The objective of this study is to compare the difference in outcome between open partial lateral anal sphincterotomy and application of topical 0.2% nitroglycerin ointment for the treatment of chronic anal fissure.
  
  
  METHODS
  This was a quasi-experimental study carried out between January 16, 2007 and January 15, 2008 in the Surgical Department of Jinnah Hospital, Lahore, Pakistan. Sixty consecutive cases with a clinical diagnosis of chronic anal fissure were recruited in the study. All recruited patients met the study inclusion criteria and were randomly assigned to one of the two groups. Group A was managed conservatively using topical 0.2% nitroglycerin ointment, whereas Group B underwent open partial lateral anal sphincterotomy. Both groups were followed up at 1 week, 2 weeks, 4 weeks, and 6 weeks after the treatment.
  
  
  RESULTS
  All the patients complained of pain. A total of 43 (71.7%) patients had pain with constipation, whereas 31 (51.7%) patients had bleeding per rectum. Upon clinically examining the anal area, tenderness was elicited in all 60 (100%) patients. Group A included 30 (11 females and 19 males) cases treated with topical 0.2% nitroglycerin ointment and Group B included 30 (11 females and 19 males) cases who underwent open partial lateral anal sphincterotomy. In Group A, only 15 patients with fissures were successfully treated (50%). By contrast, 28 (93%) patients with fissures in Group B were successfully treated, and only two (7%) remained uncured. These two patients (6.6%) in Group B suffered from incontinence due to flatus and feces as a complication of the procedure.
  
  
  CONCLUSIONS
  This quasi-experimental study demonstrates that open partial lateral internal sphincterotomy is superior to topical 0.2% nitroglycerin application in the treatment of chronic anal fissure, with good symptomatic relief, high rate of healing, fewer side effects, and a very low rate of early continence disturbances.
authors: Department of Vascular/General Surgery, Queen Elizabeth Hospital, Gateshead, United Kingdom. Electronic address: drmia@hotmail.co.uk.
authors: Muhammad I
authors: MI
authors: Aslam
authors: Surgical Unit I, General Surgery Department, Jinnah Hospital, Lahore, Pakistan.
authors: Arif
authors: A
authors: Pervaiz
authors: Department of Vascular/General Surgery, Queen Elizabeth Hospital, Gateshead, United Kingdom.
authors: Rodrigo
authors: R
authors: Figueiredo
mesh_terms: D000287:Administration, Topical; D001003:Anal Canal / Q000601:surgery*; D002908:Chronic Disease; D005260:Female; D005401:Fissure in Ano / Q000628:therapy*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage*; D009824:Ointments / Q000008:administration & dosage; D011183:Postoperative Complications; D016896:Treatment Outcome
chemical_list: D009824:Ointments; D005996:Nitroglycerin
keywords: chronic anal fissure; open partial lateral anal sphincterotomy; topical 0.2% nitroglycerin