title: GSTT1 null genotype contributes to hepatocellular carcinoma risk: a meta-analysis.
abstract: Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and hepatocellular carcinoma (HCC) risk have reported conflicting results. Therefore, we conducted this meta-analysis to provide more precise evidence. Databases including PubMed, Embase, SCOPUS, ISI Web of Science, and Wangfang were searched for relevant studies. Potential sources of heterogeneity were also assessed by subgroup analysis. Funnel plots and Egger's linear regression were used to test publication bias among the articles. Finally, a total of 28 studies involving 3,897 HCC patients and 6,117 controls were included in this meta-analysis. In a combined analysis, the summary odds ratio for HCC of the GSTT1 null genotype was 1.43 (95% confidence interval (CI) 1.22–1.68, P < 10(−5)). In the subgroup analysis by ethnicity, significantly increased risks were found in East Asians for GSTT1 null polymorphism, while no significant associations were found among Caucasian, South Asian, and African populations. When stratified by a source of controls, both population- and hospital-based studies get consistent positive results. By pooling data from 10 studies (1,639 cases and 2,224 controls) that considered combinations of GSTT1 and GSTM1 genotypes, a statistically significant increased risk for HCC (odd ratio = 1.85, 95% CI 1.37–2.49) was detected for individuals with combined deletion mutations in both genes compared with positive genotypes. No evidence of publication bias was observed. Our result suggests that the GSTT1 null genotype contributes to an increased risk of HCC in East Asians and that interaction between unfavorable GSTs genotypes may exist.
authors: Ke-Ji
authors: KJ
authors: Chen
authors: Fei
authors: F
authors: Fan
authors: Yi
authors: Y
authors: Wang
authors: Gong-Tian
authors: GT
authors: Wei
authors: Lei
authors: L
authors: Hu
authors: Feng
authors: F
authors: Xu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D012306:Risk
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase
references: Cancer Res. 1985 Jun;45(6):2471-7
references: 3986787
references: Eur J Cancer. 2006 Jan;42(1):73-7
references: 16314088
references: Environ Health Perspect. 1993 Apr;100:293-306
references: 8354177
references: Hepatology. 2008 Oct;48(4):1312-27
references: 18821591
references: Atherosclerosis. 2000 Apr;149(2):451-62
references: 10729397
references: J Med Virol. 2012 Jul;84(7):1009-17
references: 22585716
references: Arch Intern Med. 2000 Nov 27;160(21):3227-30
references: 11088082
references: Dis Markers. 2010;28(6):369-76
references: 20683151
references: Am J Epidemiol. 1999 Apr 1;149(7):621-9
references: 10192309
references: J Natl Cancer Inst. 2003 Oct 1;95(19):1485-8
references: 14519756
references: Lancet. 1989 Oct 28;2(8670):1006-8
references: 2572740
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Egypt J Immunol. 2008;15(2):125-34
references: 20306695
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Ann Intern Med. 1997 Nov 1;127(9):820-6
references: 9382404
references: Cancer Epidemiol Biomarkers Prev. 2001 Jul;10(7):785-91
references: 11440964
references: DNA Cell Biol. 2008 Dec;27(12):687-94
references: 18816171
references: Cancer Res. 2003 Aug 1;63(15):4594-601
references: 12907637
references: Cancer Causes Control. 2005 Sep;16(7):831-8
references: 16132793
references: J Clin Epidemiol. 2003 Apr;56(4):297-303
references: 12767405
references: Nature. 2005 Aug 18;436(7053):946-52
references: 16107834
references: Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48
references: 11751440
references: Zhonghua Liu Xing Bing Xue Za Zhi. 2005 Oct;26(10):777-81
references: 16536303
references: World J Gastroenterol. 2005 Jan 14;11(2):272-4
references: 15633230
references: Carcinogenesis. 2001 Aug;22(8):1289-94
references: 11470760
references: Pharmacogenetics. 2004 Jul;14(7):453-63
references: 15226677
references: Clin Trials. 2008;5(2):116-20
references: 18375649
references: Hepatol Res. 2006 Sep;36(1):48-55
references: 16884947
references: Pharmacology. 2000 Sep;61(3):154-66
references: 10971201
references: J Med Virol. 1994 Jul;43(3):276-80
references: 7523582
references: Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):373-9
references: 15734960
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: J Cancer Res Clin Oncol. 2003 Jun;129(6):355-60
references: 12759747
references: Int J Cancer. 1991 Sep 30;49(3):377-80
references: 1655659
references: Am J Ind Med. 1998 Feb;33(2):157-63
references: 9438048
references: Int J Cancer. 2001 Oct 15;94(2):153-6
references: 11668491
references: J Clin Epidemiol. 2011 Apr;64(4):383-94
references: 21195583
references: BMJ. 2007 Nov 3;335(7626):914-6
references: 17974687
references: BMJ. 2003 Sep 6;327(7414):557-60
references: 12958120