title: Impacts of chloramine-T treatment on antioxidant enzyme activities and genotoxicity in rainbow trout, Oncorhynchus mykiss (Walbaum).
abstract: Juvenile rainbow trout Oncorhynchus mykiss (Walbaum) were exposed to therapeutic, and higher concentrations of chloramine-T (Cl-T) to assess the effects of this chemical on the antioxidant enzyme system and genetic structure. Red blood cells acetylcholinesterase, ∆-aminolevulinic acid dehydratase, paraoxonase and liver glutathione S-transferase activity were increased at 10 and 20 mg L(-1) Cl-T-exposed fish, while they were decreased at 30 mg L(-1) Cl-T-exposed fish. On the other hand, liver catalase activity and liver protein levels increased at 10 mg L(-1) and decreased at 20 and 30 mg L(-1) concentrations of Cl-T. Liver super-oxide dismutase activity decreased at 10 mg L(-1) and 20 mg L(-1) Cl-T and increased at 30 mg L(-1) of Cl-T. Compared to control, comet assay indicated that Cl-T did not cause significant DNA damage to red blood cells of the fish. Results indicate that 10 or 20 mg L(-1) Cl-T can be safely used to prevent or treat external parasitic and bacterial infection of rainbow trout.
authors: Department of Fisheries Technology Engineering, Faculty of Marine Science, Karadeniz Technical University, Trabzon, Turkey.
authors: H
authors: H
authors: Boran
authors: I
authors: I
authors: Altinok
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002700:Chloramines / Q000633:toxicity*; D020552:Comet Assay / Q000662:veterinary; D004249:DNA Damage; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology*; D029941:Fish Proteins / Q000235:genetics* / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010088:Oxidoreductases / Q000378:metabolism; D014105:Tosyl Compounds / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D002700:Chloramines; D029941:Fish Proteins; D014105:Tosyl Compounds; C016300:chloramine-T; D010088:Oxidoreductases
keywords: chloramine-T; comet assay; enzyme activity; genotoxicity; rainbow trout