title: Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies.
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder among older people. However, no cure or disease-modifying treatments are currently available, and the molecular and cellular mechanisms responsible for the etiology of AD remain under debate. Recent studies suggest that the immune system has a crucial role in AD pathogenesis and, thus, immunotherapy might be a promising new treatment. Here, we review the roles of the immune system in AD pathogenesis as well as recent developments in immunotherapy for AD. Furthermore, we hypothesize that age-related immune dysregulation, which might be a consequence of the age-associated chronic inflammation known as 'inflammaging', significantly contributes to AD pathogenesis. Finally, we propose various immunological mechanisms for the development of safe and effective therapies for AD.
authors: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital and Institute of Field Surgery, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China.
authors: Yu-Hui
authors: YH
authors: Liu
authors: Fan
authors: F
authors: Zeng
authors: Ye-Ran
authors: YR
authors: Wang
authors: Hua-Dong
authors: HD
authors: Zhou
authors: Brian
authors: B
authors: Giunta
authors: Jun
authors: J
authors: Tan
authors: Yan-Jiang
authors: YJ
authors: Wang
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D002908:Chronic Disease; D015195:Drug Design; D006801:Humans; D007107:Immune System / Q000473:pathology; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000503:physiopathology / Q000628:therapy