title: A NEW FRAMEWORK FOR ANALYZING WHITE MATTER MATURATION IN EARLY BRAIN DEVELOPMENT.
abstract: The trajectory of early brain development is marked by rapid growth presented by volume but also by tissue property changes. Capturing regional characteristics of axonal structuring and myelination via neuroimaging requires analysis of longitudinal image data with multiple modalities. Complementary to earlier studies of volume and cortical folding analysis, this paper focuses on white matter tissue changes as seen in multimodal MRI and DTI. We propose a new framework for analyzing early maturation in white matter that generates a normative spatiotemporal model and provides 3D maps of absolute and relative indices of maturation. The method, using a continuous model of intensity changes using modified Legendre polynomials, has been applied to a multimodal dataset (T1W, T2W, PD, DTI) with 8 subjects that have been scanned at approximately 2 weeks, 1 year, and 2 years. We demonstrate that spatial maturation maps generated from different modalities capture different properties of white matter growth which might lead to a better understanding of the underlying neurobiology.
authors: Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah 84112.
authors: Marcel
authors: M
authors: Prastawa
authors: Neda
authors: N
authors: Sadeghi
authors: John H
authors: JH
authors: Gilmore
authors: Weili
authors: W
authors: Lin
authors: Guido
authors: G
authors: Gerig
keywords: Brain development; Diffusion tensor imaging; Growth trajectory; Longitudinal analysis; MRI
references: Neuroimage. 2004;23 Suppl 1:S151-60
references: 15501084
references: Pediatr Res. 2008 Oct;64(4):325
references: 19258902
references: IEEE Trans Med Imaging. 1999 Aug;18(8):712-21
references: 10534053
references: Hum Brain Mapp. 2008 Jan;29(1):14-27
references: 17318834
references: Acad Radiol. 2007 Nov;14(11):1350-66
references: 17964459
references: J Neurosci. 2008 Nov 19;28(47):12176-82
references: 19020011
references: AJNR Am J Neuroradiol. 2009 Feb;30(2):290-6
references: 19001533
references: Neuroimage. 2006 May 1;30(4):1121-32
references: 16413790
references: Inf Process Med Imaging. 2007;20:257-69
references: 17633705