title: Controlled microstructuring of janus particles based on a multifunctional poly(ethylene glycol).
abstract: A novel water insoluble, multifunctional poly(ethylene glycol), poly(hydrazide ethylene glycol-co-benzyl glycidyl ether) (P(HZ-co-BnGE)), is synthesized via thiol-ene click reaction of poly(allyl glycidyl ether-co-benzyl glycidyl ether) (P(AGE-co-BnGE)). The base polymer P(AGE-co-BnGE) is previously prepared by anionic ring-opening copolymerization of the corresponding monomers. To demonstrate utility, bicompartmental microspheres and microcylinders containing P(HZ-co-BnGE) in one of the compartments are prepared via electrohydrodynamic (EHD) co-jetting. Next, spatially controlled surface reactivity toward sugars is demonstrated by selective binding of 2α-mannobiose to the P(HZ-co-BnGE) compartment only, as confirmed by a carbohydrate-lectin-binding assay. These sugar-reactive hydrazide-presenting microparticles have potential applications for glyco-targeted drug delivery.
authors: Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
authors: Ekaterina
authors: E
authors: Sokolovskaya
authors: Jaewon
authors: J
authors: Yoon
authors: Asish C
authors: AC
authors: Misra
authors: Stefan
authors: S
authors: Bräse
authors: Jörg
authors: J
authors: Lahann
mesh_terms: D057930:Click Chemistry; D004337:Drug Carriers / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D037102:Lectins / Q000737:chemistry / Q000378:metabolism; D008351:Mannans / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D037102:Lectins; D008351:Mannans; D011108:Polymers; C014647:mannobiose; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols
keywords: functional materials; microparticles; poly(ethylene glycol); ring-opening polymerization; sugar conjugation