title: Moderate compared to low dietary intake of trans-fatty acids impairs strength of old and aerobic capacity of young SAMP8 mice in both sexes.
abstract: The senescence accelerated SAMP8 mouse is a model for sarcopenia and provides an opportunity to study the effects of lifelong dietary composition on the loss of physical function with age. We studied the effects of trans-fatty acids (2 % of total energy, TFA diet) on the loss of strength and aerobic exercise capacity (VO₂peak) with age. SAMP8 mice were studied at two ages (young, 25 weeks; old, 60 weeks) and on two diets (control vs TFA). Body composition, grip strength, VO₂peak, blood metabolites, and biochemical parameters were assessed. Body weight, fat mass, and body fat percentage all increased with age (p < 0.05) but were not significantly impacted by diet. There was a significant age-related decline in total grip strength as well as that normalized to fat-free mass (FFM) (p < 0.05) with a further decrease at old age in these metrics of strength on the TFA diet vs control diet (p < 0.05). Total VO₂peak exhibited no change with age or diet, but when normalized to FFM, VO₂peak exhibited age and TFA-related declines (p < 0.05). Intramuscular triacylglycerol (p < 0.05) and collagen content (p < 0.05) significantly increased with age, while blood triacylglycerol was increased by the TFA diet (p < 0.05). These data further characterize the SAMP8 mouse as a model for sarcopenia and indicate that dietary fatty acid composition can impact the degree of this age-related loss of physical function.
authors: Department of Exercise Science and Rutgers Center for Lipid Research, Rutgers University, 70 Lipman Drive, Loree Building, New Brunswick, NJ, 08901, USA.
authors: Jesse
authors: J
authors: Liou
authors: Marc A
authors: MA
authors: Tuazon
authors: Alex
authors: A
authors: Burdzy
authors: Gregory C
authors: GC
authors: Henderson
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D009124:Muscle Proteins / Q000378:metabolism; D053580:Muscle Strength; D018384:Oxidative Stress; D010101:Oxygen Consumption; D010807:Physical Endurance; D005082:Physical Exertion; D050050:Protein Carbonylation; D055948:Sarcopenia / Q000378:metabolism* / Q000503:physiopathology; D044242:Trans Fatty Acids / Q000008:administration & dosage*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D009124:Muscle Proteins; D044242:Trans Fatty Acids; D014280:Triglycerides; D003094:Collagen
references: N Engl J Med. 1999 Jun 24;340(25):1933-40
references: 10379016
references: Biochim Biophys Acta. 2012 May;1822(5):650-6
references: 22142563
references: J Nutr. 2005 Mar;135(3):562-6
references: 15735094
references: J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):242-8
references: 15031308
references: Anal Biochem. 1976 May 7;72:248-54
references: 942051
references: Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G987-95
references: 18772365
references: J Biol Chem. 1957 May;226(1):497-509
references: 13428781
references: J Appl Physiol (1985). 2000 Jul;89(1):81-8
references: 10904038
references: J Am Diet Assoc. 2002 Nov;102(11):1621-30
references: 12449285
references: Gerontology. 2007;53(4):218-23
references: 17356288
references: Arch Biochem Biophys. 1961 May;93:440-7
references: 13786180
references: Br J Nutr. 2009 Feb;101(4):465-73
references: 18842159
references: Eur J Clin Nutr. 1991 Aug;45(8):375-82
references: 1760997
references: Int J Mol Sci. 2010 Apr 12;11(4):1509-26
references: 20480032
references: Am J Clin Nutr. 2003 Sep;78(3):370-5
references: 12936917
references: Atheroscler Suppl. 2006 May;7(2):1-4
references: 16713396
references: Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E272-7
references: 15727953
references: Exp Gerontol. 2005 Jul;40(7):562-72
references: 16023814
references: Free Radic Biol Med. 2008 Feb 15;44(4):594-601
references: 18021747
references: Anal Biochem. 2011 Jun 1;413(1):66-8
references: 21324304
references: Br J Nutr. 2003 May;89(5):631-9
references: 12720583
references: Am J Clin Nutr. 2004 Dec;80(6):1521-5
references: 15585763
references: J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):295-9
references: 19864639
references: Am J Physiol. 1997 Oct;273(4):E790-800
references: 9357810
references: Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15364-9
references: 8986817
references: Obesity (Silver Spring). 2009 Jun;17(6):1200-7
references: 19584878
references: J Appl Physiol (1985). 1998 Sep;85(3):1011-6
references: 9729577
references: J Nutr. 2004 Apr;134(4):874-9
references: 15051840
references: Br J Nutr. 2005 Sep;94(3):346-52
references: 16176604
references: Free Radic Biol Med. 1999 Feb;26(3-4):303-8
references: 9895220
references: J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1183-9
references: 19622801