title: Anatomical characteristics of the cerebral surface in bulimia nervosa.
abstract: BACKGROUND
  The aim of this study was to examine morphometric features of the cerebral surface in adolescent and adult female subjects with bulimia nervosa (BN).
  
  
  METHODS
  Anatomical magnetic resonance images were acquired from 34 adolescent and adult female subjects with BN and 34 healthy age-matched control subjects. We compared the groups in the morphological characteristics of their cerebral surfaces while controlling for age and illness duration.
  
  
  RESULTS
  Significant reductions of local volumes on the brain surface were detected in frontal and temporoparietal areas in the BN compared with control participants. Reductions in inferior frontal regions correlated inversely with symptom severity, age, and Stroop interference scores in the BN group.
  
  
  CONCLUSIONS
  These findings suggest that local volumes of inferior frontal regions are smaller in individuals with BN compared with healthy individuals. These reductions along the cerebral surface might contribute to functional deficits in self-regulation and to the persistence of these deficits over development in BN.
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York; Eating Disorders Research Unit, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York. Electronic address: MarshR@childpsych.columbia.edu.
authors: Rachel
authors: R
authors: Marsh
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors: Mihaela
authors: M
authors: Stefan
authors: Center for Developmental Neuropsychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors: Ravi
authors: R
authors: Bansal
authors: Center for Developmental Neuropsychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors: Xuejun
authors: X
authors: Hao
authors: Eating Disorders Research Unit, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors: B Timothy
authors: BT
authors: Walsh
authors: Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York; Center for Developmental Neuropsychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
authors: Bradley S
authors: BS
authors: Peterson
mesh_terms: D000293:Adolescent; D000375:Aging / Q000473:pathology; D052018:Bulimia Nervosa / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D057190:Stroop Test; D066127:White Matter / Q000473:pathology
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: Bulimia nervosa; Eating disorders; Frontal cortex; Frontostriatal; MRI; Surface morphology
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