title: Association of interleukin-18 gene polymorphisms with the outcomes of hepatitis C virus infection in high-risk Chinese Han population.
abstract: Interleukin 18 (IL-18) gene polymorphisms have been reported to be associated with the outcomes of hepatitis C virus (HCV) infection in Americans, Indians and Europeans. We aimed to investigate whether the association can be replicated in Chinese Han population. Three IL-18 variants, -656G>T, -137G>C and +105A>C, were genotyped in three independent Han cohorts consisting of 552 cases and 784 controls. By using logistic regression analysis and multiple testing, haplotype GCC were associated with a protection from susceptibility to HCV. After stratified analysis, both the carriage of -137C allele in the older or hemodialysis subgroup and the carriage of +105C allele in the younger subgroup were found to be significantly associated with a decreased risk of HCV susceptibility. By using logistic regression analysis and multiple testing for the resolution of HCV infection, our study showed that +105C allele and haplotype GGC displayed a negative effect on HCV persistence. After stratified analysis, a significantly decreased risk for HCV persistence was found in +105C allele in the subgroups of young, male or female, drug user or hemodialysis and HCV-1 or HCV mixed genotype. No significant association was observed between -656G>T and the outcomes of HCV infection. Our results demonstrated that the carriage of -137C allele, +105C allele, haplotype -656G/-137C/+105C and haplotype -656G/-137G/+105C of IL-18 gene may contribute to better outcomes of HCV infection in high-risk Chinese Han population.
authors: School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, Jiangsu, China.
authors: Ming
authors: M
authors: Yue
authors: Jia-jia
authors: JJ
authors: Wang
authors: Shai-di
authors: SD
authors: Tang
authors: Le
authors: L
authors: Feng
authors: Yun
authors: Y
authors: Zhang
authors: Yan
authors: Y
authors: Liu
authors: Jie
authors: J
authors: Wang
authors: Xiao-zhao
authors: XZ
authors: Deng
authors: Ke
authors: K
authors: Xu
authors: Jun
authors: J
authors: Zhang
mesh_terms: D000328:Adult; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D016174:Hepacivirus / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D007223:Infant; D020382:Interleukin-18 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups; D012306:Risk
chemical_list: D020382:Interleukin-18
keywords: CIs; ELISA; FDR; HCC; HCV; HD; Hepatitis C virus; IL-18; IL-18R; IL-1β; IRAK-4; Infection; Interleukin-18; MyD88; NF-kB; NFAT; ORs; Persistence; Polymorphism; SD; SNPs; Susceptibility; confidence intervals; enzyme-linked immunosorbent assay; false discovery rate; hemodialysis; hepatitis C virus; hepatocellular carcinoma; interleukin 1 receptor-associated kinase 4; interleukin-18; interleukin-18 receptor; interleukin-1β; myeloid differentiation factor 88; nuclear factor of activated T cells; odds ratios; single nucleotide polymorphisms; standard deviations; transcription factor nuclear factor-kB