title: Iatrogenic Cushing's syndrome induced by posaconazole.
abstract: Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing's syndrome. We present a patient with common-variable immunodeficiency who received 7 years of itraconazole therapy for bronchial colonization with Aspergillus in combination with inhaled fluticasone without any Cushingoid symptoms. After a switch to posaconazole, the patient developed Cushingoid symptoms.
authors: Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Paris, France.
authors: Benoit
authors: B
authors: Pilmis
authors: Hélène
authors: H
authors: Coignard-Biehler
authors: Vincent
authors: V
authors: Jullien
authors: Olivier
authors: O
authors: Hermine
authors: Philippe
authors: P
authors: Touraine
authors: Marc
authors: M
authors: Lecuit
authors: Olivier
authors: O
authors: Lortholary
mesh_terms: D000730:Androstadienes / Q000009:adverse effects*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D001980:Bronchi / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D001993:Bronchodilator Agents / Q000009:adverse effects*; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D000068298:Fluticasone; D006801:Humans; D007049:Iatrogenic Disease; D017964:Itraconazole / Q000627:therapeutic use*; D008875:Middle Aged; D014230:Triazoles / Q000009:adverse effects*
chemical_list: D000730:Androstadienes; D000935:Antifungal Agents; D001993:Bronchodilator Agents; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000068298:Fluticasone
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