title: Antiproliferative effect of alkylglycerols as vehicles of butyric acid on colon cancer cells.
abstract: The anticarcinogenic activity of synthetic 1-O-octadecyl-2,3-dibutyroilglycerol (D-SCAKG) in tumor-cell line of colonocytes (SW620) was performed. The effect of the previously digested D-SCAKG under in vitro intestinal conditions was compared to the bioactivity of non-digested D-SCAKG. Antiproliferative activity of each individual product from digestion (1-O-octadecyl-2-butyroilglycerol; 1-O-octadecyl glycerol; butyric acid) was also performed. The impact of solubilization of lipid products within micellar structures was also tested. The 1-O-octadecyl glycerol was the most active compound, followed by 1-O-octadecyl-2-butyroilglycerol, D-SCAKG and butyric acid. The 1-O-octadecyl glycerol and butyric acid were the only molecules that showed antiproliferative effect in absence of micelles. Digested D-SCAKG was 4-fold more effective than non-digested D-SCAKG. A synergism between 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol was evidenced. As summary, the synthetic D-SCAKG seems to be an interesting antitumoral lipid against colonocytes, especially after previous intestinal digestion, and mainly due to the synergism of the major products, namely 1-O-octadecyl-2-butyroilglycerol and 1-O-octadecyl glycerol. At the same time, 1-O-octadecyl-2-butyroilglycerol would constitute a stable esterified form of butyric acid for its vehiculization.
authors: Imdea-Food Institute, CEI UAM+CSIC, 28049 Madrid, Spain.
authors: S
authors: S
authors: Molina
authors: M I
authors: MI
authors: Moran-Valero
authors: D
authors: D
authors: Martin
authors: L
authors: L
authors: Vázquez
authors: T
authors: T
authors: Vargas
authors: C F
authors: CF
authors: Torres
authors: A
authors: A
authors: Ramirez de Molina
authors: G
authors: G
authors: Reglero
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry* / Q000494:pharmacology*; D020148:Butyric Acid / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005990:Glycerol / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans
chemical_list: D016588:Anticarcinogenic Agents; D020148:Butyric Acid; D005990:Glycerol
keywords: 1-O-octadecyl glycerol; 1-O-octadecyl-2,3-dibutyroilglycerol; 1-O-octadecyl-2-butyroilglycerol; AKG; Alkylglycerols; Antiproliferative compounds; Butyric acid; D-SCAKG; DMEM; DMSO; Dulbecco's modified Eagle's medium; FBS; GC; Lipid digestion; Lipid-delivery pro-drugs; M-SCAKG; MTT; PAF; dimethyl sulfoxide; fetal bovine serum; gas chromatography; platelet-activating factor; thiazolyl blue tetrazolium bromide