title: Bone mineral density following surgical oophorectomy and tamoxifen adjuvant therapy for breast cancer.
abstract: BACKGROUND
  In premenopausal women treated for breast cancer, loss of bone mineral density (BMD) follows from menopause induced by chemotherapy or loss of ovarian function biochemically or by surgical oophorectomy. The impact on BMD of surgical oophorectomy plus tamoxifen therapy has not been described.
  
  
  METHODS
  In 270 Filipino and Vietnamese premenopausal patients participating in a clinical trial assessing the impact of the timing in the menstrual cycle of adjuvant surgical oophorectomy on breast cancer outcomes, BMD was measured at the lumbar spine and femoral neck before this treatment, and at 6, 12, and 24 months after surgical and tamoxifen therapies.
  
  
  RESULTS
  In women with a pretreatment BMD assessment and at least 1 other subsequent BMD assessment, no significant change in femoral neck BMD was observed over the 2-year period (-0.006 g/cm2 , -0.8%, P = .19), whereas in the lumbar spine, BMD fell by 0.045 g/cm2 (4.7%) in the first 12 months (P < .0001) and then began to stabilize.
  
  
  CONCLUSIONS
  Surgically induced menopause with tamoxifen treatment is associated with loss of BMD at a rate that lessens over 2 years in the lumbar spine and no significant change of BMD in the femoral neck.
authors: International Breast Cancer Research Foundation, Madison, Wisconsin.
authors: Richard R
authors: RR
authors: Love
authors: Gregory S
authors: GS
authors: Young
authors: Adriano V
authors: AV
authors: Laudico
authors: Nguyen
authors: N
authors: Van Dinh
authors: Gemma B
authors: GB
authors: Uy
authors: Le Hong
authors: le H
authors: Quang
authors: Arturo S
authors: AS
authors: De La Peña
authors: Rodney B
authors: RB
authors: Dofitas
authors: Orlino C
authors: OC
authors: Bisquera
authors: Stephen S S
authors: SS
authors: Siguan
authors: Jonathan D S
authors: JD
authors: Salvador
authors: Maria Rica
authors: MR
authors: Mirasol-Lumague
authors: Narciso S
authors: NS
authors: Navarro
authors: Nguyen Dieu
authors: ND
authors: Linh
authors: David
authors: D
authors: Jarjoura
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D015519:Bone Density; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D005272:Femur Neck / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008161:Lumbosacral Region / Q000503:physiopathology; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D017697:Premenopause / Q000187:drug effects; D013131:Spine / Q000187:drug effects / Q000503:physiopathology; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen
keywords: adjuvant drug therapy; bone mineral density; breast cancer; femoral neck; menopause; oophorectomy; spine; tamoxifen