title: Anti-diabetic activities of the methanol leaf extracts of Hymenocardia acida (tul.) in alloxan-induced diabetic rats.
abstract: The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg - 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls.
authors: Department of Veterinary Physiology, Biochemistry and Pharmacology, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. ihechi2109@yahoo.com
authors: Ihechiluru I
authors: II
authors: Ezeigbo
authors: Isaac U
authors: IU
authors: Asuzu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D005905:Glyburide
keywords: Alloxan monohydrate; Diabetes mellitus; Glibenclamide; Hymenocardia acida; Lipid profile
references: Circulation. 1999 Sep 7;100(10):1134-46
references: 10477542
references: Phytomedicine. 1999 Mar;6(1):59-66
references: 10228613
references: Clin Chem. 1972 Jun;18(6):499-502
references: 4337382
references: Atherosclerosis. 2001 Jun;156(2):357-61
references: 11395032
references: J Ethnopharmacol. 2003 Aug;87(2-3):221-5
references: 12860312
references: Diabetes Metab Rev. 1987 Apr;3(2):551-70
references: 3552532
references: Circulation. 1979 Jan;59(1):8-13
references: 758126
references: Am J Cardiol. 1991 Jun 1;67(15):1185-9
references: 2035438
references: Clin Chem. 1982 Oct;28(10):2077-80
references: 6812986
references: Fitoterapia. 2003 Feb;74(1-2):7-13
references: 12628387
references: Am J Physiol. 1986 Sep;251(3 Pt 2):H571-80
references: 2944394
references: N Engl J Med. 1995 Feb 23;332(8):512-21
references: 7830734
references: Clin Chem. 1974 Apr;20(4):470-5
references: 4818200
references: Cardiovasc Res. 1999 Feb;41(2):323-33
references: 10341832
references: Planta Med. 2002 Jul;68(7):581-90
references: 12142989