title: Traditional herbal medicine: a review of potential of inhibitory hepatocellular carcinoma in basic research and clinical trial.
abstract: Although significantly develops in hepatocellular carcinoma (HCC), features of HCC remain an aggressive cancer with a dismal outcome. Traditional Chinese medicine (TCM), specifically Chinese herbal medicine (CHM), is one of the most popular complementary and alternative medicine modalities worldwide. The use of heat-clearing and detoxicating (Chinese named qingre jiedu) CHM has attracted great attention as an alternative antitumor including HCC considering its low toxicity and high activity. Together these reports indicate that CHM is a promising anti-HCC herbal remedy in basic research. For patients with advanced HCC, CHM including formula and single combined with transcatheter arterial chemoembolization or chemotherapy is able to decrease tumor growth and the side effect of toxicity and improve overall survival, quality of life, and immune function. Due to its abundance, low cost, and safety in consumption, CHM remains a species with tremendous potential for further investigation in HCC.
authors: Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China ; National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Xi'an 710004, China ; Shaanxi Province Engineering Research Center of Biotherapy and Translation Medicine, Xi'an 710004, China.
authors: Zhidong
authors: Z
authors: Wang
authors: Jun
authors: J
authors: Li
authors: Yuanyuan
authors: Y
authors: Ji
authors: Peng
authors: P
authors: An
authors: Shu
authors: S
authors: Zhang
authors: Zongfang
authors: Z
authors: Li
references: Cancer. 2009 Nov 15;115(22):5132-8
references: 19672999
references: Chin J Integr Med. 2010 Apr;16(2):102-8
references: 20473733
references: Molecules. 2011 May 27;16(6):4389-400
references: 21623310
references: J Cancer Res Clin Oncol. 2009 Sep;135(9):1245-55
references: 19277711
references: Biofactors. 2008;34(4):303-12
references: 19850985
references: J Altern Complement Med. 2008 Oct;14(8):1027-42
references: 18990050
references: World J Gastroenterol. 2009 Sep 28;15(36):4538-46
references: 19777612
references: Oncol Rep. 2010 Feb;23(2):413-21
references: 20043102
references: Oncology. 2013;84 Suppl 1:28-33
references: 23428855
references: Integr Cancer Ther. 2005 Sep;4(3):219-29
references: 16113029
references: Evid Based Complement Alternat Med. 2012;2012:908601
references: 23326293
references: BMC Complement Altern Med. 2012 Sep 05;12:146
references: 22947144
references: World J Gastroenterol. 2010 Sep 14;16(34):4281-90
references: 20818811
references: Oncol Rep. 2013 Mar;29(3):1080-6
references: 23254951
references: Exp Ther Med. 2013 Mar;5(3):695-700
references: 23408474
references: Oncol Rep. 2009 Dec;22(6):1357-63
references: 19885587
references: J Tradit Chin Med. 2008 Sep;28(3):205-10
references: 19004205
references: Carcinogenesis. 2013 Jun;34(6):1331-42
references: 23393227
references: World J Gastroenterol. 2008 Dec 28;14(48):7321-8
references: 19109865
references: Chin J Integr Med. 2011 Sep;17(9):691-7
references: 21910071
references: BMC Cancer. 2010 Oct 25;10:580
references: 20969807
references: Int J Mol Sci. 2013 Jan 11;14(1):1370-82
references: 23344047
references: Chin J Integr Med. 2012 May;18(5):339-44
references: 22549390
references: Evid Based Complement Alternat Med. 2012;2012:751046
references: 22778776
references: Int J Oncol. 2013 Jan;42(1):202-10
references: 23165653
references: Asian Pac J Cancer Prev. 2012;13(10):5319-21
references: 23244156
references: Cell Biol Int. 2008 Mar;32(3):337-43
references: 18262806
references: CA Cancer J Clin. 2012 Nov-Dec;62(6):394-9
references: 23070690
references: World J Gastroenterol. 2007 Aug 21;13(31):4192-8
references: 17696247
references: Biochem Pharmacol. 2012 May 1;83(9):1251-60
references: 22305746
references: Int J Oncol. 2012 Sep;41(3):969-78
references: 22684543
references: Explore (NY). 2011 Jan-Feb;7(1):37-43
references: 21194671
references: Int J Oncol. 2012 Oct;41(4):1431-42
references: 22858649
references: Dig Dis Sci. 2009 Feb;54(2):389-94
references: 18592377
references: BMC Cancer. 2010 May 20;10:219
references: 20487542
references: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Mar;29(3):257-60
references: 19548447
references: Clin Cancer Res. 2011 Dec 1;17(23):7294-302
references: 21976539