title: Genetic contributions to labor pain and progress.
abstract: Studies on genetic contributions to labor analgesia have essentially evaluated the μ-opioid receptor gene (OPRM1), with some evidence that p.118A/G of OPRM1 influences the response to neuraxial opioids. As for labor progress, the β2-adrenergic receptor gene (ADRB2) is associated with preterm labor and delivery, and impacts the course of labor. Taken together though, there is no evidence that pharmacogenetic testing is needed or beneficial in the context of obstetric anesthesia; however, realizing the influence of genetic variants on specific phenotypes provides the rationale for a more cautious interpretation of clinical studies that attempt to find a dose-regimen that fits all.
authors: Department of Anesthesiology and Pain Medicine, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195-6540, USA. rulandau@u.washington.edu
authors: Ruth
authors: R
authors: Landau
mesh_terms: D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000235:genetics; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D048949:Labor Pain / Q000235:genetics*; D007743:Labor, Obstetric / Q000235:genetics*; D007744:Obstetric Labor Complications / Q000235:genetics*; D007752:Obstetric Labor, Premature / Q000235:genetics; D058748:Pain Perception; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000235:genetics; D018045:Receptors, Oxytocin / Q000235:genetics
chemical_list: C553443:ADRB2 protein, human; D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; C569600:OXTR protein, human; D018343:Receptors, Adrenergic, beta-2; D017450:Receptors, Opioid, mu; D018045:Receptors, Oxytocin; D002394:Catechol O-Methyltransferase; D005283:Fentanyl
keywords: ADRB2; Genetics; Labor pain; OPRM1; Polymorphism