title: Thymine modified amphiphilic biodegradable copolymers for photo-cross-linked micelles as stable drug carriers.
abstract: A photo-cross-linked micelle is synthesized via photodimerization of thymine moieties fabricated from amphiphilic block copolymers (mPEG-b-P(LA-co-MPT). The crosslinking behavior is monitored by UV-Vis spectra and (1) H NMR. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that cross-linked micelles had smaller sizes than their uncross-linked precursors. In vitro studies reveal that cross-linking of the micelle cores results in a slow drug release and faster cellular uptake in comparison with uncross-linked ones in MCF-7 and Hela cells. Moreover, the paclitaxel (PTX)-loaded core-cross-linked micelles exhibit similar anticancer efficacy as free PTX. This work provides a convenient tool for designing a more stable structure in the blood circulation to realize a controlled drug delivery.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Graduate School of Chinese Academy of Sciences, Beijing, 100049, China.
authors: Huihui
authors: H
authors: Kuang
authors: Hongyan
authors: H
authors: He
authors: Jie
authors: J
authors: Hou
authors: Zhigang
authors: Z
authors: Xie
authors: Xiabin
authors: X
authors: Jing
authors: Yubin
authors: Y
authors: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000528:radiation effects; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000528:radiation effects; D006801:Humans; D008027:Light; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D010316:Particle Size; D055668:Photochemical Processes; D011091:Polyesters / Q000138:chemical synthesis* / Q000528:radiation effects; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000528:radiation effects; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; C000589321:methoxyl poly(ethylene glycol)-b-poly(lactide-co-2-methyl-2-(3-(2,3-dihydroxylpropylthio)propyloxycarbonyl)propylene carbonate 1-(carboxymethyl)thymine); D011092:Polyethylene Glycols; D004317:Doxorubicin; D017239:Paclitaxel; D013941:Thymine
keywords: amphiphilic copolymers; degradable; drug delivery; photo-cross-linking; thymine