title: Multiple myeloma presenting as bilateral breast lumps in pregnant woman.
abstract: BACKGROUND
  Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast.
  
  
  METHODS
  We describe the case of a 39-year-old woman diagnosed with an IgG lambda light-chain MM (Durie-Salmon stage IIIA, International Staging System II) in the 26th week of pregnancy, presenting with bilateral breast lumps. Dexamethasone (20 mg/m(2)/day on days 1-4, 9-12, and 17-20) was given as an induction agent to decrease tumor mass during pregnancy. Adverse response to dexamethasone was minor with excellent tolerance. A healthy baby was delivered at week 34 of gestation.
  
  
  CONCLUSIONS
  Breast nodules revealing MM are extremely rare. Clinical and radiological features are atypical. Presentation during pregnancy is extremely rare, making anti-MM treatment potentially challenging.
authors: Department of Medical Oncology, Habib Bourguiba University Hospital, 3029, Sfax, Tunisia, racem.bouzguenda@gmail.com.
authors: Racem
authors: R
authors: Bouzguenda
authors: Afef
authors: A
authors: Khanfir
authors: Nabil
authors: N
authors: Toumi
authors: Kais
authors: K
authors: Chaaben
authors: Yosr
authors: Y
authors: Hentati
authors: Lobna
authors: L
authors: Ayadi
authors: Wiem
authors: W
authors: Feki
authors: Jamel
authors: J
authors: Daoud
authors: Mounir
authors: M
authors: Frikha
mesh_terms: D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D001940:Breast / Q000473:pathology*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D010388:Pelvis / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color
chemical_list: D003907:Dexamethasone
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