title: [Hypertensive crisis: pathogenesis, clinic, treatment].
abstract: Contemporary data on mechanisms of development, types, and clinical picture of hypertensive crisis (HC) are presented. Algorithms of rational therapy of uncomplicated and complicated HC are considered. Appropriateness of the use in HC of antihypertensive drugs with multifactorial action is stressed. These drugs include urapidil - an antihypertensive agent with complex mechanism of action. Blocking mainly the postsynaptic 1-adrenoreceptors urapidil attenuates vasoconstrictor effect of catecholamines and decreases total peripheral resistance. Stimulation of 5HT1-receptors of medullary vasculomotor center promotes lowering of elevated vascular tone and prevents development of reflex tachycardia.
authors: A L
authors: AL
authors: Vertkin
authors: A V
authors: AV
authors: Topolianskiĭ
authors: A U
authors: AU
authors: Abdullaeva
authors: M A
authors: MA
authors: Alekseev
authors: Kh A
authors: KhA
authors: Shakhmanaev
mesh_terms: D000465:Algorithms; D000784:Aortic Dissection / Q000209:etiology / Q000517:prevention & control; D000959:Antihypertensive Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D001014:Aortic Aneurysm; D001794:Blood Pressure / Q000187:drug effects; D019468:Disease Management; D004630:Emergencies; D004638:Emergency Treatment / Q000379:methods; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006974:Hypertension, Malignant / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D020343:Hypertensive Encephalopathy / Q000209:etiology / Q000517:prevention & control; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil