title: Hashimoto's thyroiditis: an accidental discovery of a lingual thyroid in a 7-year-old child.
abstract: An ectopic thyroid located at the base of the tongue is a rare entity, resulting from early developmental defects of thyroid gland embryogenesis during its descent from the foramen caecum to its normal eutopic pretracheal site. This condition is the main cause of congenital primary hypothyroidism, even though signs and symptoms of thyroid dysfunction may also appear later in childhood. Lingual thyroid may sometimes present with symptoms of respiratory obstruction or feeding difficulties. We illustrate the case of a 7-year-old girl with subclinical hypothyroidism due to Hashimoto's thyroiditis arising in a lingual thyroid. She had never suffered from upper airway obstructive symptoms, but did refer a 3-month history of cough. Rapid normalisation of thyroid-stimulating hormone levels and termination of the cough were attained when the L-thyroxine treatment started. After 6 months a significant reduction of lingual thyroid size was also noted. The diagnostic procedures and therapeutic options in childhood are discussed.
authors: Department of Paediatrics, Catholic University, Rome, Italy.
authors: Michela
authors: M
authors: Mariani
authors: Alessandra
authors: A
authors: Palpacelli
authors: Annalisa
authors: A
authors: Mussoni
authors: Aurora Natalia
authors: AN
authors: Rossodivita
mesh_terms: D058070:Asymptomatic Diseases; D002648:Child; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D033162:Incidental Findings; D047268:Lingual Goiter / Q000175:diagnosis; D046151:Lingual Thyroid / Q000175:diagnosis*
references: Mol Cell Endocrinol. 2010 Jul 8;323(1):35-54
references: 20026174
references: Indian J Endocrinol Metab. 2012 May;16(3):441-3
references: 22629516
references: Eur J Endocrinol. 2011 Sep;165(3):375-82
references: 21715415
references: Hormones (Athens). 2011 Oct-Dec;10(4):261-9
references: 22281882
references: Acta Otorhinolaryngol Ital. 2009 Aug;29(4):213-7
references: 20161880
references: J Clin Endocrinol Metab. 1955 Jun;15(6):668-79
references: 14367482
references: Arch Intern Med. 1987 Nov;147(11):2046-8
references: 3675109
references: Laryngoscope. 2008 Jul;118(7):1174-9
references: 18418276
references: Dysphagia. 2001 Summer;16(3):220-3
references: 11453571
references: Laryngoscope. 2007 Nov;117(11):1969-73
references: 17828053
references: J Clin Endocrinol Metab. 2010 Oct;95(10):4509-10
references: 20926539
references: Otolaryngol Head Neck Surg. 2001 Sep;125(3):274-6
references: 11555767
references: Thyroid. 2003 Jun;13(6):607
references: 12930606
references: Am J Otolaryngol. 2001 Jul-Aug;22(4):276-81
references: 11464325
references: Intern Med. 1998 Apr;37(4):381-4
references: 9630198
references: Ann Endocrinol (Paris). 2006 Jun;67(3):245-8
references: 16840916
references: Thyroid. 2001 Dec;11(12):1191-6
references: 12186508
references: J Clin Endocrinol Metab. 2011 Oct;96(10):2959-67
references: 21976744
references: Eur J Pediatr Surg. 2011 Oct;21(5):339-40
references: 21544779
references: Head Neck. 2004 Nov;26(11):995-8
references: 15508119