title: Viral subversion of the nuclear pore complex.
abstract: The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
authors: Lady Davis Institute at the Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada. valerie.lesage@mail.mcgill.ca
authors: Valerie
authors: V
authors: Le Sage
authors: Andrew J
authors: AJ
authors: Mouland
mesh_terms: D002467:Cell Nucleus / Q000821:virology; D003593:Cytoplasm / Q000821:virology; D006801:Humans; D022022:Nuclear Pore / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*; D018406:Virus Physiological Phenomena; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins
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