title: Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.
abstract: Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ahr deficiency caused increased intestinal Th17 cells, raising the possibility that group 3 ILCs could negatively regulate Th17 cells. Reduced innate interleukin-22 (IL-22) in Ahr-deficient mice allowed expansion of commensal segmented filamentous bacteria (SFB), known to promote Th17 cells. Compared to Rorc(+/+)Ahr(-/-) mice, Rorc(gfp/+)Ahr(-/-) mice had further reduced group 3 ILCs and were prone to spontaneous colitis with increased SFB and Th17 cells. Innate expression of Ahr played a protective role in T-cell-mediated experimental colitis by suppressing pathogenic Th17 cells. Our data reveal an intricate balance between ILCs and Th17 cells regulated by Ahr and commensal flora.
authors: Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors: Ju
authors: J
authors: Qiu
authors: Xiaohuan
authors: X
authors: Guo
authors: Zong-Ming E
authors: ZM
authors: Chen
authors: Lei
authors: L
authors: He
authors: Gregory F
authors: GF
authors: Sonnenberg
authors: David
authors: D
authors: Artis
authors: Yang-Xin
authors: YX
authors: Fu
authors: Liang
authors: L
authors: Zhou
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D003092:Colitis / Q000276:immunology*; D020381:Interleukin-17 / Q000378:metabolism; D007378:Interleukins / Q000096:biosynthesis / Q000378:metabolism*; D007422:Intestines / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D000097043:Interleukin-22
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018336:Receptors, Aryl Hydrocarbon; D000097043:Interleukin-22
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