title: Bisphenol A and chronic disease risk factors in US children.
abstract: OBJECTIVE
  To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample.
  
  
  METHODS
  We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption).
  
  
  RESULTS
  We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.
  
  
  CONCLUSIONS
  Higher levels of urinary BPA were associated with a higher odds of obesity (BMI >95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.
authors: Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.
authors: Donna S
authors: DS
authors: Eng
authors: Joyce M
authors: JM
authors: Lee
authors: Achamyeleh
authors: A
authors: Gebremariam
authors: John D
authors: JD
authors: Meeker
authors: Karen
authors: K
authors: Peterson
authors: Vasantha
authors: V
authors: Padmanabhan
mesh_terms: D000293:Adolescent; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000652:urine; D015992:Body Mass Index; D002648:Child; D002908:Chronic Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D009749:Nutrition Surveys; D009765:Obesity / Q000139:chemically induced* / Q000453:epidemiology*; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D012307:Risk Factors; D014481:United States; D055105:Waist Circumference; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: NHANES; bisphenol A; children; endocrine disrupting chemical; obesity
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