title: Reduction of retinal sensitivity in eyes with reticular pseudodrusen.
abstract: OBJECTIVE
  To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods.
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects underwent color fundus photography, infrared reflectance (IR), fundus autofluorescence (FAF), and microperimetry.
  
  
  RESULTS
  The similarity in the number of reticular pseudodrusen was evaluated through inter-observer intraclass correlation coefficients, which ranged from 0.852-0.944. IR could detect reticular pseudodrusen within the center circle area in 12 eyes, whereas blue-channel fundus photography and FAF could only detect these lesions in 1 and 3 eyes, respectively. The number of reticular pseudodrusen correlated among the different imaging modalities (P < .001 for all) for all areas of the macula, except the center. The mean retinal sensitivity in eyes with reticular pseudodrusen was lower in all areas of the macula, compared with normal eyes (P < .001 for all). The number of reticular pseudodrusen correlated with retinal sensitivity in all areas by IR imaging (P = .003, P < .001, P = .003 for center, inner ring, outer ring, respectively), in the inner and outer rings by blue-channel fundus photography (P < .001 for both), and in the inner and outer rings by FAF (P < .001 and P = .001, respectively).
  
  
  CONCLUSIONS
  Although multiple imaging modalities are capable of quantifying reticular pseudodrusen, IR appears to have the best ability to do so as compared to blue-channel photography and FAF. The distribution and number of reticular pseudodrusen lesions are closely associated with retinal sensitivity.
authors: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: ohoto@kuhp.kyoto-u.ac.jp.
authors: Sotaro
authors: S
authors: Ooto
authors: Abdallah A
authors: AA
authors: Ellabban
authors: Naoko
authors: N
authors: Ueda-Arakawa
authors: Akio
authors: A
authors: Oishi
authors: Hiroshi
authors: H
authors: Tamura
authors: Kenji
authors: K
authors: Yamashiro
authors: Akitaka
authors: A
authors: Tsujikawa
authors: Nagahisa
authors: N
authors: Yoshimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010781:Photography; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D015593:Retinal Drusen / Q000175:diagnosis / Q000503:physiopathology*; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green