title: Cell-derived microparticles: new targets in the therapeutic management of disease.
abstract: Intercellular communication is essential to maintain vital physiological activities and to regulate the organism's phenotype. There are a number of ways in which cells communicate with one another. This can occur via autocrine signaling, endocrine signaling or by the transfer of molecular mediators across gap junctions. More recently communication via microvesicular shedding has gained important recognition as a significant pathway by which cells can coordinate the spread and dominance of selective traits within a population. Through this communication apparatus, cells can now acquire and secure a survival advantage, particularly in the context of malignant disease. This review aims to highlight some of the functions and implications of microparticles in physiology of various disease states, and present a novel therapeutic strategy through the regulation of microparticle production.
authors: School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia.
authors: Ariane
authors: A
authors: Roseblade
authors: Frederick
authors: F
authors: Luk
authors: Tristan
authors: T
authors: Rawling
authors: Alison
authors: A
authors: Ung
authors: Georges E R
authors: GE
authors: Grau
authors: Mary
authors: M
authors: Bebawy
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D015658:HIV Infections / Q000378:metabolism; D006801:Humans; D016779:Malaria, Cerebral / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism