title: Anticholinesterase insecticide action at the murine male reproductive system.
abstract: The present report describes for the first time that anticholinesterase type insecticides specifically inhibit the fatty acid amide hydrolase and/or monoacylglycerol lipase, as secondary target(s), in the murine male reproductive system (testis and epididymis cauda), thereby presumably being involved with spermatotoxicity such as deformity, underdevelopment, and reduced motility.
authors: Department of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
authors: Yuki
authors: Y
authors: Noro
authors: Motohiro
authors: M
authors: Tomizawa
authors: Yuki
authors: Y
authors: Ito
authors: Himiko
authors: H
authors: Suzuki
authors: Keisuke
authors: K
authors: Abe
authors: Michihiro
authors: M
authors: Kamijima
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005832:Genital Diseases, Male / Q000139:chemically induced; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013094:Spermatozoa / Q000187:drug effects*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D000099252:Fatty Acid Amide Hydrolases
keywords: Anticholinesterase insecticides; Chlorpyrifos; Fatty acid amide hydrolase; Monoacylglycerol lipase; Organophosphate and methylcarbamate insecticides; Spermatotoxicity