title: Possible artemisinin-based combination therapy-resistant malaria in Nigeria: a report of three cases.
abstract: Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.
authors: Department of Internal Medicine, Federal Teaching Hospital Abakaliki, State of Ebonyi, Nigeria.
authors: Nnennaya Anthony
authors: NA
authors: Ajayi
authors: Kingsley Nnanna
authors: KN
authors: Ukwaja
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage* / Q000009:adverse effects; D037621:Artemisinins / Q000008:administration & dosage* / Q000009:adverse effects; D004351:Drug Resistance; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008875:Middle Aged; D009549:Nigeria; D011803:Quinine / Q000008:administration & dosage*; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin; D011803:Quinine