title: Evaluation of a strategy aimed at reducing errors in antiretroviral prescriptions for hospitalized HIV-infected patients.
abstract: OBJECTIVE
  Errors are frequently made in the prescription of antiretroviral medication for hospitalized HIV-infected patients. We had for aim to evaluate the prescription of antiretroviral drug regimens at hospital admission and the impact of a strategy implemented to prevent errors.
  
  
  METHODS
  HIV-infected patients managed by our hospital as outpatients and admitted between January 1, 2010, and December 31, 2010 (first period) and between February 1, 2011, and January 31, 2012 (second period) were included in the study. We retrospectively identified errors made in the prescription of antiretrovirals by comparing the drugs prescribed during hospitalization and the treatment documented in the outpatient file. During the second period, we implemented a strategy involving the pharmacist and the infectious disease specialist to reduce the number of errors.
  
  
  RESULTS
  Thirty-five patients were treated during the first period for 56 admissions, and 43 patients for 77 admissions during the second one. We identified 39% of medication-related errors during the first period and 42% during the second one. The most common errors were drug omission, inappropriate dosage, or failure to adjust dosage for renal insufficiency. Our intervention, during the second period, allowed correcting 36% of errors.
  
  
  CONCLUSIONS
  In our study, errors made in the prescription of antiretroviral medication were frequent and our intervention allowed correcting 36% of errors. Other strategies, such as consulting a clinical pharmacist on admission, or training prescribers should be considered.
authors: Service de pharmacie, centre hospitalier de Longjumeau, 159, rue du Président-François-Mitterrand, 91160 Longjumeau, France.
authors: S
authors: S
authors: Lauzevis
authors: F
authors: F
authors: Chaix
authors: C
authors: C
authors: Lazzerini
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D011307:Drug Prescriptions; D057286:Electronic Health Records; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006748:Hospital Departments / Q000706:statistics & numerical data; D006757:Hospital Units / Q000706:statistics & numerical data; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008508:Medication Errors / Q000517:prevention & control*; D008875:Middle Aged; D010045:Outpatients / Q000706:statistics & numerical data; D010343:Patient Admission; D010595:Pharmacists; D010607:Pharmacy Service, Hospital / Q000458:organization & administration*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D015397:Program Evaluation; D012189:Retrospective Studies; D012984:Software
chemical_list: D019380:Anti-HIV Agents
keywords: Antiretroviral treatment; HIV; Pharmacovigilance; Traitement antirétroviral; VIH