title: Differential modifications of synaptic weights during odor rule learning: dynamics of interaction between the piriform cortex with lower and higher brain areas.
abstract: Learning of a complex olfactory discrimination (OD) task results in acquisition of rule learning after prolonged training. Previously, we demonstrated enhanced synaptic connectivity between the piriform cortex (PC) and its ascending and descending inputs from the olfactory bulb (OB) and orbitofrontal cortex (OFC) following OD rule learning. Here, using recordings of evoked field postsynaptic potentials in behaving animals, we examined the dynamics by which these synaptic pathways are modified during rule acquisition. We show profound differences in synaptic connectivity modulation between the 2 input sources. During rule acquisition, the ascending synaptic connectivity from the OB to the anterior and posterior PC is simultaneously enhanced. Furthermore, post-training stimulation of the OB enhanced learning rate dramatically. In sharp contrast, the synaptic input in the descending pathway from the OFC was significantly reduced until training completion. Once rule learning was established, the strength of synaptic connectivity in the 2 pathways resumed its pretraining values. We suggest that acquisition of olfactory rule learning requires a transient enhancement of ascending inputs to the PC, synchronized with a parallel decrease in the descending inputs. This combined short-lived modulation enables the PC network to reorganize in a manner that enables it to first acquire and then maintain the rule.
authors: Departments of Biology Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel, Department of Child and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY 10016, USA and Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
authors: Yaniv
authors: Y
authors: Cohen
authors: Department of Child and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY 10016, USA and Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
authors: Donald A
authors: DA
authors: Wilson
authors: Departments of Biology Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa 31905, Israel.
authors: Edi
authors: E
authors: Barkai
mesh_terms: D000818:Animals; D004193:Discrimination Learning / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D008297:Male; D009415:Nerve Net / Q000502:physiology; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D055696:Olfactory Perception / Q000502:physiology*; D066195:Piriform Cortex / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology*; D055366:Synaptic Potentials
keywords: field potentials recordings; olfactory bulb; olfactory rule learning; orbitofrontal cortex; piriform cortex
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