title: The model for end-stage liver disease score-based system predicts short term mortality better than the current Child-Turcotte-Pugh score-based allocation system during waiting for deceased liver transplantation.
abstract: To adopt the model for end-stage liver disease (MELD) score-based system in Korea, the feasibility should be evaluated by analysis of Korean database. The aim of this study was to investigate the feasibility of the MELD score-based system compared with the current Child-Turcotte-Pugh (CTP) based-system and to suggest adequate cut-off to stratify waiting list mortality among Korean population. We included 788 adult patients listed in waiting list in Seoul National University Hospital from January 2008 to May 2011. The short-term survival until 6 months after registration was evaluated. Two hundred forty six (31.2%) patients underwent live donor liver transplantation and 353 (44.8%) patients were still waiting and 121 (15.4%) patients were dropped out due to death. Significant difference was observed when MELD score 24 and 31 were used as cut-off. Three-months survival of Status 2A was 70.2%. However, in Status 2A patients whose MELD score less than 24 (n=82), 86.6% of patients survived until 6 month. Furthermore, patients with high MELD score (≥31) among Status 2B group showed poorer survival rate (45.8%, 3-month) than Status 2A group. In conclusion, MELD score-based system can predict short term mortality better and select more number of high risk patients in Korean population.
authors: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors: Geun
authors: G
authors: Hong
authors: Kwang-Woong
authors: KW
authors: Lee
authors: Sukwon
authors: S
authors: Suh
authors: Tae
authors: T
authors: Yoo
authors: Hyeyoung
authors: H
authors: Kim
authors: Min-Su
authors: MS
authors: Park
authors: Youngrok
authors: Y
authors: Choi
authors: Nam-Joon
authors: NJ
authors: Yi
authors: Kyung-Suk
authors: KS
authors: Suh
mesh_terms: D019540:Area Under Curve; D015331:Cohort Studies; D058625:End Stage Liver Disease / Q000401:mortality* / Q000628:therapy; D006801:Humans; D016031:Liver Transplantation; D015233:Models, Statistical; D012372:ROC Curve; D012042:Registries; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D014850:Waiting Lists
keywords: Liver Diseases; Liver Transplantation; MELD Score; Mortality; Survival; Waiting Lists
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