title: Construction of dispirocyclopentanebisoxindoles via self-domino Michael-aldol reactions of 3-phenacylideneoxindoles.
abstract: A simple protocol for the construction of novel dispirocyclopentanebisoxindoles is accomplished by the base promoted domino reactions between two molecules of 3-phenacylideneoxindoles with the participation of solvents, alcohol, or other added nucleophiles such as amines or thiophenols. Significantly, this domino reaction results in the complex dispiro compounds with high yields and diastereoselectivity, which would allow construction of dispirocyclopentanebisoxindole with four and five diastereoisomeric centers using simple materials.
authors: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors: Jing
authors: J
authors: Sun
authors: Ya-Jing
authors: YJ
authors: Xie
authors: Chao-Guo
authors: CG
authors: Yan
mesh_terms: D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D013141:Spiro Compounds