title: Takayasu arteritis presenting in the context of active tuberculosis: a pediatric case.
abstract: Takayasu arteritis (TA) is a large-vessel vasculitis, most commonly presenting in young adults and more rarely in pediatric patients. An apparent association between TA and Mycobacterium tuberculosis has been noted previously, although this potential relationship is not yet understood. We present the case of a 16-year-old Haitian girl diagnosed with TA, originally presenting in the context of active tuberculosis. Our patient has been treated with antituberculosis therapy, corticosteroids, methotrexate, and rituximab to control her continued active vasculitis. With this case report, we seek to promote further exploration of the apparent association between TA and tuberculosis, as further clarification of the nature of this relationship may lead to the development of more targeted therapies and better outcomes for TA patients.
authors: Pediatric Rheumatology, Hospital for Special Surgery, NY Weill Cornell Medical Center, New York, NY, USA. waltersh@hss.edu
authors: Heather M
authors: HM
authors: Walters
authors: Cassyanne L
authors: CL
authors: Aguiar
authors: Emma Jane
authors: EJ
authors: Macdermott
authors: Alexa
authors: A
authors: Adams
authors: Laura
authors: L
authors: Barinstein
authors: Jeffrey D
authors: JD
authors: Dayton
authors: Christine
authors: C
authors: Salvatore
authors: Nandadeepa
authors: N
authors: Thimmappa
authors: Thomas J
authors: TJ
authors: Lehman
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D015897:Comorbidity; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D009169:Mycobacterium tuberculosis; D000069283:Rituximab; D013625:Takayasu Arteritis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000305:Adrenal Cortex Hormones; D058846:Antibodies, Monoclonal, Murine-Derived; D000995:Antitubercular Agents; D000069283:Rituximab; D008727:Methotrexate