title: Phytochemical and biological studies of Adiantum capillus-veneris L.
abstract: Chromatographic fractionation of the alcoholic extract of the dried fronds of Adiantum capillus-veneris L. (Adiantaceae) yielded seven compounds: four triterpenoidal compounds belonging to adiantane and filicane groups were isolated from the hexane fraction and identified as isoadiantone (1); isoadiantol-B (2); 3-methoxy-4-hydroxyfilicane (3) and 3,4-dihydroxyfilicane (4) and three flavonoids were isolated from the ethyl acetate fraction and identified as: quercetin (5), quercetin-3-O-glucoside (6) and quercetin-3-O-rutinoside (rutin) (7). The identification of the isolated compounds has been established through their physical, chemical and spectroscopic methods including IR, (1)H NMR, (13)C NMR, HSQC, HMBC, NOESY and MS. Biological studies of the total alcoholic extract, hexane fraction and some of the isolated compounds showed an anti-inflammatory activity while the hypoglycemic study of the total alcoholic extract showed a significant activity.
authors: Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
authors: Zedan Z
authors: ZZ
authors: Ibraheim
authors: Amany S
authors: AS
authors: Ahmed
authors: Yaser G
authors: YG
authors: Gouda
keywords: Adiantane; Adiantum capillus-veneris L.; Anti-inflammatory; Filicane triterpenoids; Flavonoids; Hypoglycemic
references: Phytother Res. 2001 Feb;15(1):18-21
references: 11180516
references: Fitoterapia. 2002 Aug;73(5):363-8
references: 12165329
references: J Ethnopharmacol. 2007 Jan 19;109(2):295-303
references: 16987626
references: Phytochemistry. 2001 Sep;58(2):363-7
references: 11551565
references: Pharmacol Biochem Behav. 2009 Jul;93(1):40-6
references: 19375449
references: J Ethnopharmacol. 2005 Oct 31;102(1):58-68
references: 16024194
references: Boll Soc Ital Biol Sper. 1989 May;65(5):461-3
references: 2775551
references: Tetrahedron. 1969 Aug;25(15):2939-47
references: 5802374
references: Agents Actions. 1986 Jan;17(3-4):347-9
references: 3962781
references: Atherosclerosis. 2009 Jun;204(2):476-82
references: 18977480
references: J Ethnopharmacol. 2010 Mar 2;128(1):123-30
references: 20051261
references: Pharmacol Res. 2010 Apr;61(4):288-97
references: 19892018
references: J Ethnopharmacol. 2009 May 4;123(1):45-50
references: 19429338
references: J Ethnopharmacol. 2003 Dec;89(2-3):199-209
references: 14611883
references: FEBS Lett. 2008 Jan 23;582(2):310-8
references: 18154734
references: Farmaco. 2001 Sep;56(9):683-7
references: 11680812
references: Phytochemistry. 2008 Jun;69(9):1875-9
references: 18433808
references: J Ethnopharmacol. 2000 Jan;69(1):45-56
references: 10661883
references: Prostaglandins Leukot Essent Fatty Acids. 2010 Jan;82(1):45-50
references: 19897347
references: Free Radic Biol Med. 1996;20(3):331-42
references: 8720903
references: Chem Pharm Bull (Tokyo). 2008 Mar;56(3):374-7
references: 18310952
references: J Ethnobiol Ethnomed. 2008 Mar 11;4:7
references: 18334029
references: Bioorg Med Chem Lett. 2010 Mar 1;20(5):1528-31
references: 20153184
references: Fitoterapia. 2005 Jan;76(1):1-25
references: 15664457
references: J Ethnopharmacol. 2008 Oct 28;119(3):482-500
references: 18805475
references: J Ethnopharmacol. 1998 May;61(1):17-30
references: 9687078
references: J Ethnopharmacol. 2010 Mar 24;128(2):322-35
references: 20138210
references: J Ethnopharmacol. 1999 May;65(2):141-8
references: 10465654
references: Ann Pharmacother. 2000 Mar;34(3):317-21
references: 10917376
references: J Ethnopharmacol. 2008 Jan 17;115(2):327-9
references: 17997240
references: Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1273-5
references: 12237552
references: J Pharm Pharmacol. 2003 Jan;55(1):131-42
references: 12625877
references: Agents Actions. 1991 Sep;34(1-2):264-9
references: 1665298
references: J Ethnopharmacol. 2001 Dec;78(2-3):171-91
references: 11694363