title: Hepatic tissue damage induced in Meriones ungliculatus due to infection with Babesia divergens-infected erythrocytes.
abstract: Babesia divergens is an intraerythrocytic parasite which is capable of infecting a wide range of vertebrates causing huge economic losses. Histopathological, hematological and biochemical changes during B. divergens infection in female Meriones ungliculatus were reported. Animals were challenged with 5 × 10(6) B. divergens-infected erythrocytes. Parasitemia were maximum at day 5 postinfection where all gerbils died. Infection of gerbils with Babesia induced a significant decrease in erythrocytic count as well as the hemoglobin concentration and hematocrit percentage but leucocytes were increased significantly when compared to uninfected gerbils. Liver enzymes aspartate aminotransferase (AST) and aniline aminotransferase (ALT) were significantly increased while albumin and total bilirubin were significantly decreased at day 5 postinfection with B. divergens-infected erythrocytes. Histopathological scores of inflammation after infection of gerbils were done using Ischak's activity index and indicated that the liver was severely affected. In conclusion, the study indicated that the course of infection by B. divergens-induced alternations in hematology, biochemistry and histopathology of the hepatic tissue.
authors: Zoology Department, College of Science, King Saud University, Saudi Arabia ; Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt.
authors: M A
authors: MA
authors: Dkhil
authors: S
authors: S
authors: Al-Quraishy
authors: A S
authors: AS
authors: Abdel-Baki
keywords: Babesia; Gerbils; Hepatic tissue damage
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