title: Complications of upper cervical spine trauma in elderly subjects. A systematic review of the literature.
abstract: The frequency of cervical spine trauma in elderly patients is increasing with most injuries occurring in the upper cervical spine. These fractures are associated with a risk of sometimes life-threatening complications, although very few studies have specifically analyzed this. The goal of this study was to identify the incidence of complications in the literature (mortality and morbidity) following upper cervical spine trauma in elderly patients.
  
  
  METHODS
  A systematic search was performed on the MEDLINE database without limiting the search by language or date to identify all studies reporting the rate of complications after upper cervical spine trauma in patients over the age of 60.
  
  
  RESULTS
  Twenty-four observational studies were included, four were comparative. These studies included a total of 857 patients, mean age 76. Nearly all traumas were odontoid process fractures, and most were treated surgically (57%). The median mortality rate was 9.2% (Q1-Q3: 2.5-19.6) and the median rate of short-term complications was 15.4% (Q1-Q3: 5.8-26.9). The main late stage complication was nonunion, which developed in a mean 10 to 12% depending on the type of treatment.
  
  
  CONCLUSIONS
  Complications following cervical spine trauma are frequent in elderly patients whatever the type of treatment. Knowledge of the rate of complications in the literature and the potential risk factors is essential for the clinician to improve the information provided to patients and to prevent complications.
  
  
  METHODS
  Systematic review of the literature. Level of evidence IV.
authors: Service de chirurgie orthopédique, hôpital Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.
authors: P
authors: P
authors: Jubert
authors: G
authors: G
authors: Lonjon
authors: C
authors: C
authors: Garreau de Loubresse
mesh_terms: D000367:Age Factors; D002574:Cervical Vertebrae / Q000293:injuries*; D014943:Global Health; D006801:Humans; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016103:Spinal Fractures / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D015996:Survival Rate / Q000639:trends
keywords: Axis; Cervical atlas; Complications; Spinal injuries; Systematic review