title: Orientation-specific attachment of polymeric microtubes on cell surfaces.
abstract: Tubular particles presenting heterogeneous regions of chemistry on the tube-ends versus the side are fabricated and are shown to control the particle orientation on the surface of live lymphocytes. Controlling the orientation of anisotropic microparticles on cell surfaces is of interest for biomedical applications and drug delivery in particular, since it can be used to promote or resist particle internalization.
authors: Massachusetts Institute of Technology, Department of Chemical Engineering, 77 Massachusetts Avenue, MA, 02139, USA.
authors: Jonathan B
authors: JB
authors: Gilbert
authors: Janice S
authors: JS
authors: O'Brien
authors: Harini S
authors: HS
authors: Suresh
authors: Robert E
authors: RE
authors: Cohen
authors: Michael F
authors: MF
authors: Rubner
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D011073:Polyamines / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D011073:Polyamines; C063994:polyallylamine; C006903:carbopol 940
keywords: anisotropic; drug delivery; janus; polyelectrolyte multilayer; polymer