title: [Acetaminophen and the liver: damage at therapeutic dose levels?].
abstract: The possibility of liver intoxication at therapeutic doses of paracetamol (maximal dailydose of 4 x 1 g) is supported by retrospective, but not by controlled prospective studies. Intended orsuicidal overdosages are frequently misjudged in retrospektive reports. Malnutrition, ethanol consumption, and drugs inducing hepatic metabolism are no established riskfactors at therapeutic dose levels. Dose adaptation in existing liver disease is recommended for longer-term use.Transient increases in transaminase values (> 3 x upper limits of normal) after regulardoses of paracetamol are not proof of hepatic damage unless associated with corresponding symptoms or laboratory changes indicative of compromised hepatic function (total bilirubin, INR). There is insufficient evidence of liver injury by paracetamol at regular dose levels.
authors: Pharmakologe und Toxikologe, RWTH Aachen. karluwe.petersen@post.rwth-aachen.de
authors: K-U
authors: KU
authors: Petersen
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000428:Alcohol Drinking / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen