title: Association between uric acid and coronary collateral circulation in patients with stable coronary artery disease.
abstract: Serum uric acid (SUA) levels have been proposed as a biomarker of coronary artery disease (CAD) and coronary collateral circulation (CCC). We investigated the association between SUA levels and development of CCC in patients with stable CAD. Consecutive patients (n = 480) with stable CAD who underwent coronary angiography and documented total occlusion in 1 of the major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell (WBC), creatinine, platelet count, and SUA were significantly higher in patients with poor CCC than in those with good CCC. After multivariate analysis, high levels of SUA were an independent predictor of CCC together with levels of fasting blood glucose and WBC. The receiver-operating characteristic analysis provided a cutoff value of 5.65 mg/dL for SUA to predict poor CCC with 60% sensitivity and 66% specificity. High levels of SUA may be associated with poor CCC in patients with stable CAD.
authors: 1Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors: Onur Kadir
authors: OK
authors: Uysal
authors: Durmus Yildiray
authors: DY
authors: Sahin
authors: Mustafa
authors: M
authors: Duran
authors: Caner
authors: C
authors: Turkoglu
authors: Arafat
authors: A
authors: Yildirim
authors: Zafer
authors: Z
authors: Elbasan
authors: Bugra
authors: B
authors: Ozkan
authors: Kamuran
authors: K
authors: Tekin
authors: Aysegul Ulgen
authors: AU
authors: Kunak
authors: Yucel
authors: Y
authors: Yilmaz
authors: Mehmet Gungor
authors: MG
authors: Kaya
authors: Mustafa
authors: M
authors: Gur
authors: Murat
authors: M
authors: Cayli
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003097:Collateral Circulation; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: coronary angiography; coronary artery disease; coronary collateral circulation; uric acid