title: Skinflammation and drug toxicity--a delicate balance.
abstract: Loss of epidermal growth factor receptor function in epidermal keratinocytes triggers a disfiguring acneiform rash through the coordinate activation of innate and adaptive immune defense mechanisms (Mascia et al. and Lichtenberger et al., this issue).
authors: Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA.
authors: Mario E
authors: ME
authors: Lacouture
authors: Ulrich
authors: U
authors: Rodeck
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000276:immunology*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008297:Male; D011799:Quinazolines / Q000009:adverse effects*; D012867:Skin / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; C512478:EGFR protein, human; C541485:EGFR protein, mouse; D066246:ErbB Receptors; D000077156:Gefitinib