title: Evaluation of the potential role of a new mutation in mabA in modifying the response of Mycobacterium tuberculosis to isoniazid.
abstract: A new mutation in mabA, Thr4Ile, was identified in a Mycobacterium tuberculosis isolate from a patient whose culture remained positive after treatment. The same mutation was found in another 5 patients infected by different strains. A putative role for this mutation in the process of diminishing susceptibility to isoniazid is evaluated.
authors: Servicio de Microbiología Clínica y Enfermedades Infecciosas. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES06/06/0058), Spain.
authors: María
authors: M
authors: Alonso
authors: Miguel
authors: M
authors: Martínez-Lirola
authors: Juan José
authors: JJ
authors: Palacios
authors: Ángela
authors: Á
authors: Menéndez
authors: Marta
authors: M
authors: Herranz
authors: Susana
authors: S
authors: Martínez
authors: Emilio
authors: E
authors: Bouza
authors: Darío
authors: D
authors: García-de-Viedma
mesh_terms: D064431:3-Oxoacyl-(Acyl-Carrier-Protein) Reductase / Q000235:genetics* / Q000502:physiology; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001483:Base Sequence; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D016415:Sequence Alignment; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D064431:3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; D007538:Isoniazid
keywords: Isoniazid; Mutation; Resistance; mabA