title: The potential role of CD16+ Vγ2Vδ2 T cell-mediated antibody-dependent cell-mediated cytotoxicity in control of HIV type 1 disease.
abstract: Increasing evidence has suggested that HIV infection severely damages the Vγ2Vδ2 (Vδ2) T cells that play an important role in the first-line host response to infectious disease. However, little is known about Vδ2 T cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) in HIV disease. We found that although the CD16(+) Vδ2 T cell subset hardly participated in phosphoantigen responses dominated by the CD16(-) Vδ2 T cell subset, the potency of the ADCC function of Vδ2 T cells was correlated with the frequency of the CD16(+) subset. Thus, two distinct and complementary Vδ2 T cell subsets discriminated by CD16 were characterized to explore the respective impacts of HIV-1 infection on them. HIV-1 disease progression was not only associated with the phosphoantigen responsiveness of the CD16(-) Vδ2 subset, but also with the ability of the CD16(+) Vδ2 subset to kill antibody-coated target cells. Furthermore, both of the two Vδ2 functional subsets could be partially restored in HIV-infected patients with antiretroviral therapy. Notably, in the context of an overall HIV-mediated Vδ2 T cell depletion, despite the decline of phosphoantigen-responsive CD16(-) Vδ2 cells, CD16(+) Vδ2 cell-mediated ADCC was not compromised but exhibited a functional switch with dramatic promotion of degranulation in the early phase of HIV infection and chronic infection with slower disease progression. Our study reveals functional characterizations of the two Vδ2 T cell subsets with different activation pathways during HIV-1 infection and provides a rational direction for activating the CD16(+) Vδ2 T cells capable of mediating ADCC as a means to control HIV-1 disease.
authors: 1 Wuhan Institute of Virology , Chinese Academy of Sciences, Wuhan, China .
authors: Xuan
authors: X
authors: He
authors: Hua
authors: H
authors: Liang
authors: Kunxue
authors: K
authors: Hong
authors: Haishan
authors: H
authors: Li
authors: Hong
authors: H
authors: Peng
authors: Yangyang
authors: Y
authors: Zhao
authors: Manxue
authors: M
authors: Jia
authors: Yuhua
authors: Y
authors: Ruan
authors: Yiming
authors: Y
authors: Shao
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D017452:Receptors, IgG / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017452:Receptors, IgG
references: J Exp Med. 2003 Jan 20;197(2):163-8
references: 12538656
references: Mol Med. 1997 Jan;3(1):60-71
references: 9132281
references: Immunol Today. 1998 Jun;19(6):253-6
references: 9639988
references: AIDS. 2013 Jun 19;27(10):1557-62
references: 23525030
references: Immunity. 2009 Aug 21;31(2):184-96
references: 19699170
references: J Immunol Methods. 2004 Nov;294(1-2):15-22
references: 15604012
references: Clin Infect Dis. 2008 May 1;46(9):1466-72
references: 18419457
references: J Immunol. 1991 Nov 15;147(10):3459-65
references: 1834741
references: J Infect Dis. 1999 Oct;180(4):1338-41
references: 10479168
references: J Virol. 2009 Sep;83(17):8705-12
references: 19553339
references: Trends Immunol. 2003 Apr;24(4):213-9
references: 12697454
references: J Infect Dis. 2004 Apr 15;189(8):1482-6
references: 15073686
references: Nature. 1995 May 11;375(6527):155-8
references: 7753173
references: J Immunol. 1996 Jul 1;157(1):449-61
references: 8683151
references: Leukemia. 2007 Feb;21(2):356-9; author reply 359
references: 17251901
references: Microbes Infect. 2003 May;5(6):491-8
references: 12758278
references: Science. 1994 Apr 8;264(5156):267-70
references: 8146660
references: Nature. 1998 Jan 29;391(6666):502-6
references: 9461220
references: J Infect Dis. 2012 May 1;205(9):1448-55
references: 22454465
references: J Immunol. 1990 May 1;144(9):3375-84
references: 2329275
references: Clin Exp Immunol. 1989 Feb;75(2):206-10
references: 2522839
references: Blood. 2004 Aug 15;104(4):942-7
references: 15117761
references: Blood. 2011 Nov 24;118(22):5824-31
references: 21926353
references: Nat Rev Immunol. 2002 May;2(5):336-45
references: 12033739
references: AIDS Res Hum Retroviruses. 2003 Jan 1;19(1):21-9
references: 12581513
references: N Engl J Med. 2009 Dec 3;361(23):2209-20
references: 19843557
references: Immunol Today. 1997 Jan;18(1):22-6
references: 9018970
references: J Virol. 2001 Aug;75(15):6953-61
references: 11435575
references: Blood. 2004 Sep 15;104(6):1801-7
references: 15178578
references: Cytotherapy. 2012 Feb;14(2):173-81
references: 22029653
references: Blood. 2012 Feb 9;119(6):1418-27
references: 22180442