title: Autophagy and human parturition: evaluation of LC3 expression in placenta from spontaneous or medically induced onset of labor.
abstract: Induction of labor is one of the most used procedures in obstetrics, performed to achieve vaginal delivery through cervical ripening and stimulation of uterine contractions. We investigated the impact of induction of labor upon placental autophagy, a catabolic pathway activated in response to alteration of the physiological intracellular conditions. We collected 28 singleton placentas at the time of uncomplicated term vaginal delivery (7 spontaneous onset of labor, 21 induced labor). Autophagy was evaluated by immunohistochemistry, immunofluorescence, and immunoblotting. No significant difference in the autophagy expression was found between spontaneous or induced onset of labor. We found an inverse relationship between autophagy expression and the maternal prepregnancy body mass index, irrespective of the mode of labor onset. This result could be related to the nutritional maternal habits before and throughout pregnancy rather than rapid metabolic changes during labor.
authors: Unit of Obstetrics and Gynecology, Department of Health Sciences, San Paolo Hospital Medical School, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy.
authors: Laura
authors: L
authors: Avagliano
authors: Eleonora
authors: E
authors: Virgili
authors: Chiara
authors: C
authors: Garò
authors: Federica
authors: F
authors: Quadrelli
authors: Patrizia
authors: P
authors: Doi
authors: Michele
authors: M
authors: Samaja
authors: Gaetano Pietro
authors: GP
authors: Bulfamante
authors: Anna Maria
authors: AM
authors: Marconi
mesh_terms: D001343:Autophagy / Q000235:genetics*; D015992:Body Mass Index; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007751:Labor, Induced; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D036801:Parturition / Q000235:genetics / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D003346:Corticotropin-Releasing Hormone
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