title: [Assessment value of preoperative neutrophil-lymphocyte ratio for the prognosis of patients with colorectal cancer after radical operation].
abstract: OBJECTIVE
  To assess the value of preoperative neutrophil-lymphocyte ratio (NLR) for prognosis in patients with colorectal cancer after radical operation.
  
  
  METHODS
  Clinical data of 140 patients with colorectal cancer undergoing radical operation in the Department of General Surgery of General Hospital of PLA from July 2005 to July 2011 were analyzed retrospectively. According to preoperative NLR, patients were divided into the low NLR group (NLR<5, n=105) and the high NLR group (NLR≥5, n=35). The overall 5-year survival rates of two groups were compared and the independent risk factors were examined by univariate analysis and Cox model.
  
  
  RESULTS
  The overall 5-year survival rates of the low and high NLR groups were 74.8% and 54.7% respectively with significant difference (P=0.03). Univariate analysis revealed depth of tumor, lymph nodes metastasis, TMN stage and NLR were associated with survival (P<0.05, P<0.01). Cox model showed that NLR was independent risk factor of prognosis (RR=1.068, 95%CI:1.009-1.129, P=0.02).
  
  
  CONCLUSIONS
  Preoperative NLR≥5 predicts poorer prognosis of colorectal cancer patients.
authors: Department of General Surgery, General Surgery Institute, General Hospital of PLA, Beijing 100853, China. xuyingx@126.com.
authors: Hai-liang
authors: HL
authors: Liu
authors: Xiao-hui
authors: XH
authors: Du
authors: Pei-ming
authors: PM
authors: Sun
authors: Chun-hong
authors: CH
authors: Xiao
authors: Zhen-yu
authors: ZY
authors: Zou
authors: Ying-xin
authors: YX
authors: Xu
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate