title: Empathy and contextual social cognition.
abstract: Empathy is a highly flexible and adaptive process that allows for the interplay of prosocial behavior in many different social contexts. Empathy appears to be a very situated cognitive process, embedded with specific contextual cues that trigger different automatic and controlled responses. In this review, we summarize relevant evidence regarding social context modulation of empathy for pain. Several contextual factors, such as stimulus reality and personal experience, affectively link with other factors, emotional cues, threat information, group membership, and attitudes toward others to influence the affective, sensorimotor, and cognitive processing of empathy. Thus, we propose that the frontoinsular-temporal network, the so-called social context network model (SCNM), is recruited during the contextual processing of empathy. This network would (1) update the contextual cues and use them to construct fast predictions (frontal regions), (2) coordinate the internal (body) and external milieus (insula), and (3) consolidate the context-target associative learning of empathic processes (temporal sites). Furthermore, we propose these context-dependent effects of empathy in the framework of the frontoinsular-temporal network and examine the behavioral and neural evidence of three neuropsychiatric conditions (Asperger syndrome, schizophrenia, and the behavioral variant of frontotemporal dementia), which simultaneously present with empathy and contextual integration impairments. We suggest potential advantages of a situated approach to empathy in the assessment of these neuropsychiatric disorders, as well as their relationship with the SCNM.
authors: Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Pacheco de Melo 1860, Buenos Aires, Argentina.
authors: Margherita
authors: M
authors: Melloni
authors: Vladimir
authors: V
authors: Lopez
authors: Agustin
authors: A
authors: Ibanez
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D004645:Empathy / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D012919:Social Behavior
references: Neurology. 2001 Jun;56(11 Suppl 4):S6-10
references: 11402143
references: J Psychiatry Neurosci. 2008 Jan;33(1):34-42
references: 18197270
references: Eur J Neurosci. 2009 Feb;29(4):823-32
references: 19200075
references: Trends Cogn Sci. 2005 Aug;9(8):367-73
references: 16002323
references: J Neurosci. 2010 May 12;30(19):6482-96
references: 20463212
references: PLoS One. 2013;8(3):e57664
references: 23520477
references: Cereb Cortex. 2009 Nov;19(11):2522-34
references: 19193714
references: Cereb Cortex. 2007 Sep;17 Suppl 1:i101-9
references: 17725993
references: Psychiatry Res. 2012 Dec 30;200(2-3):184-92
references: 22766013
references: J Cogn Neurosci. 2010 May;22(5):985-97
references: 19425830
references: Trends Cogn Sci. 2009 Aug;13(8):334-40
references: 19643659
references: Neuron. 2004 Feb 19;41(4):653-62
references: 14980212
references: Neurocase. 2002;8(3):245-52
references: 12119321
references: Hum Brain Mapp. 2013 Jan;34(1):109-49
references: 22131304
references: Curr Opin Neurobiol. 2008 Apr;18(2):153-8
references: 18692571
references: Brain. 2002 Aug;125(Pt 8):1839-49
references: 12135974
references: Psychiatry Res. 2012 Jan 30;195(1-2):18-26
references: 21824666
references: J Autism Dev Disord. 2004 Apr;34(2):163-75
references: 15162935
references: Perspect Psychol Sci. 2013 Jan;8(1):56-61
references: 23710245
references: Philos Trans R Soc Lond B Biol Sci. 2009 May 12;364(1521):1325-34
references: 19528014
references: Annu Rev Neurosci. 2003;26:1-30
references: 12651967
references: Trends Cogn Sci. 2002 Jun 1;6(6):248-254
references: 12039606
references: Biol Psychiatry. 2011 Jun 15;69(12):1133-9
references: 20889144
references: Neuroimage. 2010 Jun;51(2):923-9
references: 20188182
references: Neurology. 2003 Jan 28;60(2):266-71
references: 12552042
references: Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1395-408
references: 11571031
references: J Autism Dev Disord. 2008 Mar;38(3):464-73
references: 17990089
references: J Clin Exp Neuropsychol. 2010 Mar;32(3):289-98
references: 19544133
references: Psychiatry Res. 2011 Jan 30;191(1):68-75
references: 21129937
references: Nat Rev Neurosci. 2013 Jun;14(6):417-28
references: 23635870
references: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11969-74
references: 18689686
references: J Pain. 2012 Jul;13(7):695-703
references: 22705065
references: Behav Brain Funct. 2011 Apr 13;7:8
references: 21489277
references: Ment Retard Dev Disabil Res Rev. 2004;10(4):259-71
references: 15666336
references: ScientificWorldJournal. 2006 Sep 20;6:1146-63
references: 16998603
references: Ann Gen Psychiatry. 2011 Jun 24;10:18
references: 21702932
references: Psychiatry Res. 2010 Feb 28;181(2):121-9
references: 20080395
references: J Neurosci. 2007 Feb 28;27(9):2349-56
references: 17329432
references: Annu Rev Psychol. 2009;60:653-70
references: 18793090
references: Nat Rev Neurosci. 2007 Jul;8(7):522-35
references: 17585305
references: Schizophr Res. 2012 Apr;136(1-3):70-81
references: 22306196
references: Schizophr Res. 2007 May;92(1-3):85-9
references: 17350225
references: J Autism Dev Disord. 2009 Feb;39(2):373-82
references: 18726150
references: Curr Opin Neurobiol. 2002 Apr;12(2):195-204
references: 12015237
references: Neuron. 2009 Apr 16;62(1):42-52
references: 19376066
references: Dev Neurosci. 2010;32(4):257-67
references: 20805682
references: Cogn Behav Neurol. 2005 Mar;18(1):28-36
references: 15761274
references: J Cogn Neurosci. 2007 Jan;19(1):42-58
references: 17214562
references: Curr Biol. 2010 Jun 8;20(11):1018-22
references: 20537539
references: Schizophr Res. 2008 Mar;100(1-3):191-205
references: 18234477
references: J Neuropsychiatry Clin Neurosci. 2011 Winter;23(1):74-82
references: 21304142
references: Ann N Y Acad Sci. 2009 Mar;1156:68-80
references: 19338503
references: Neuroimage. 2010 May 1;50(4):1676-82
references: 20080194
references: Hum Brain Mapp. 2009 Oct;30(10):3227-37
references: 19235883
references: Neuropsychologia. 2007 Jan 28;45(2):342-9
references: 16893555
references: J Child Psychol Psychiatry. 2000 Oct;41(7):831-46
references: 11079426
references: Neuroimage. 2009 Oct 1;47(4):2005-15
references: 19501175
references: Ciba Found Symp. 1997;208:132-56; discussion 156-61
references: 9386910
references: Trends Cogn Sci. 2007 Aug;11(8):327-32
references: 17625952
references: Neurology. 1998 Dec;51(6):1546-54
references: 9855500
references: Philos Trans R Soc Lond B Biol Sci. 2007 May 29;362(1481):801-11
references: 17412680
references: Neuroimage. 2009 Aug 15;47(2):722-34
references: 19439183
references: Front Hum Neurosci. 2010 Oct 19;4:188
references: 21079750
references: Neuropsychologia. 2006;44(6):950-8
references: 16198378
references: Neurophysiol Clin. 2000 Oct;30(5):263-88
references: 11126640
references: Brain. 2008 Sep;131(Pt 9):2464-78
references: 18550622
references: Hippocampus. 2007;17(9):813-25
references: 17598154
references: PLoS One. 2011;6(9):e25372
references: 21991394
references: Restor Neurol Neurosci. 2009;27(5):493-506
references: 19847072
references: Brain Cogn. 2008 Apr;66(3):306-10
references: 17980944
references: Front Hum Neurosci. 2012 Nov 08;6:302
references: 23162450
references: Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3389-94
references: 21300869
references: Nat Rev Drug Discov. 2012 Feb 01;11(2):141-68
references: 22293568
references: Neuropsychologia. 2012 Dec;50(14):3440-9
references: 23017597
references: Front Neurosci. 2013 May 08;7:64
references: 23658536
references: Front Hum Neurosci. 2012 Jul 02;6:191
references: 23060767
references: Soc Cogn Affect Neurosci. 2014 Jul;9(7):939-50
references: 23685775
references: Soc Cogn Affect Neurosci. 2012 Jun;7(5):535-41
references: 21737435
references: Lancet Neurol. 2011 Feb;10(2):162-72
references: 21147039
references: Cortex. 2013 May;49(5):1420-34
references: 23036522
references: Ann N Y Acad Sci. 2007 Dec;1121:528-45
references: 17846163
references: Brain Struct Funct. 2010 Jun;214(5-6):495-517
references: 20512377
references: Science. 2004 Feb 20;303(5661):1157-62
references: 14976305
references: Science. 2003 Oct 10;302(5643):290-2
references: 14551436
references: Nature. 2006 Jan 26;439(7075):466-9
references: 16421576
references: Brain Struct Funct. 2010 Jun;214(5-6):397-410
references: 20512375
references: Trends Cogn Sci. 2005 Dec;9(12):572-7
references: 16271505
references: Neurocase. 2003;9(1):44-50
references: 16210224
references: Neuropsychologia. 2006;44(5):752-61
references: 16140345
references: Psychiatry Res. 2011 Nov 30;190(1):3-8
references: 21131057
references: Schizophr Res. 2010 Sep;122(1-3):113-23
references: 20663646
references: Cortex. 2013 Apr;49(4):968-84
references: 22482695
references: Nat Rev Neurosci. 2006 Mar;7(3):242-9
references: 16495945
references: Neuron. 2010 Oct 6;68(1):149-60
references: 20920798
references: Brain Struct Funct. 2013 Nov;218(6):1355-73
references: 23412746
references: Curr Opin Neurobiol. 2001 Apr;11(2):231-9
references: 11301245
references: Neuropsychologia. 2008 Jan 15;46(1):160-73
references: 17825852
references: J Neurosci. 2009 Jul 1;29(26):8525-9
references: 19571143
references: J Behav Ther Exp Psychiatry. 2010 Jun;41(2):125-34
references: 20034611
references: Neuroimage. 2010 May 1;50(4):1357-63
references: 20123027
references: Arch Gen Psychiatry. 2007 Dec;64(12):1356-66
references: 18056543
references: Cortex. 2012 Nov-Dec;48(10):1329-41
references: 21978867
references: Neurobiol Aging. 2005 Jan;26(1):37-44
references: 15585344
references: Neuroimage. 2009 Aug 15;47(2):427-34
references: 19446642
references: Trends Cogn Sci. 2012 Nov;16(11):559-72
references: 23047070
references: Neurosci Biobehav Rev. 2012 Apr;36(4):1342-56
references: 22244985
references: Nat Rev Neurosci. 2009 Jan;10(1):59-70
references: 19096369
references: Psychiatry Res. 2002 Mar 15;109(2):149-59
references: 11927140
references: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7705-9
references: 10393884
references: Neuroimage. 2005 Feb 15;24(4):1042-51
references: 15670681
references: Eur J Neurosci. 1999 Jun;11(6):1891-8
references: 10336657
references: Schizophr Res. 2004 Jun 1;68(2-3):249-60
references: 15099607
references: Schizophr Res. 2011 Mar;126(1-3):303-5
references: 20472401
references: Neuroimage. 2007 May 15;36(1):256-67
references: 17400480
references: Philos Trans R Soc Lond B Biol Sci. 2009 May 12;364(1521):1235-43
references: 19528004
references: Biol Psychiatry. 2006 Aug 15;60(4):352-60
references: 16616731
references: Am J Hum Biol. 2011 Jan-Feb;23(1):5-21
references: 21140464
references: Neuropsychologia. 2009 Nov;47(13):2812-27
references: 19540253
references: Behav Cogn Neurosci Rev. 2004 Jun;3(2):71-100
references: 15537986
references: Schizophr Res. 2007 Aug;94(1-3):245-52
references: 17583482
references: Eur J Pain. 2005 Aug;9(4):463-84
references: 15979027
references: Pain. 2006 Nov;125(1-2):5-9
references: 16997470
references: J Neurosci. 1999 Dec 15;19(24):10869-76
references: 10594068
references: Brain Res. 2011 Jun 29;1398:72-85
references: 21624566
references: Neuropsychologia. 2008 Sep;46(11):2607-14
references: 18573266
references: PLoS One. 2013 Jun 13;8(6):e65914
references: 23785458
references: Curr Biol. 2005 Oct 25;15(20):R822-4
references: 16243017
references: Neurocase. 2001;7(2):145-60
references: 11320162
references: Ann N Y Acad Sci. 2009 Mar;1156:81-96
references: 19338504
references: Nat Rev Neurol. 2010 Nov;6(11):611-23
references: 21045795
references: Schizophr Res. 2009 Oct;114(1-3):154-60
references: 19632816
references: Nat Rev Neurosci. 2004 Aug;5(8):617-29
references: 15263892
references: Trends Cogn Sci. 2006 Jan;10(1):3-4
references: 16318924
references: Neuroimage. 2012 May 1;60(4):1947-58
references: 22361166
references: Annu Rev Psychol. 2009;60:693-716
references: 18771388
references: Hippocampus. 2010 Oct;20(10):1139-53
references: 19847786
references: Neuroimage. 2011 Feb 1;54(3):2492-502
references: 20946964
references: Dement Geriatr Cogn Disord. 2011;32(1):11-7
references: 21822019
references: J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):424-9
references: 12426410
references: Curr Biol. 2007 Oct 9;17(19):1708-13
references: 17900903
references: Pain. 2009 May;143(1-2):71-5
references: 19254825
references: Brain Lang. 2006 Sep;98(3):264-75
references: 16782185
references: Brain Struct Funct. 2010 Jun;214(5-6):655-67
references: 20512370
references: Schizophr Res. 2010 Feb;116(2-3):297-8
references: 19914806
references: Psychol Sci. 2011 Mar;22(3):306-13
references: 21270447
references: J Cogn Neurosci. 2006 Jul;18(7):1156-73
references: 16839289
references: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16518-23
references: 16260734
references: Schizophr Res. 2011 Sep;131(1-3):235-41
references: 21719258
references: J Autism Dev Disord. 2007 Apr;37(4):709-15
references: 16906462
references: Brain. 2006 Nov;129(Pt 11):2945-56
references: 17008334
references: Annu Rev Neurosci. 2012;35:1-23
references: 22715878
references: Cereb Cortex. 2012 Jan;22(1):209-20
references: 21616985
references: Biol Psychol. 2008 Apr;78(1):66-74
references: 18282653
references: Arch Gen Psychiatry. 2000 Dec;57(12):1131-7
references: 11115326
references: Brain. 2009 May;132(Pt 5):1299-309
references: 19336463
references: Trends Cogn Sci. 2005 Sep;9(9):416-23
references: 16054419
references: Ann N Y Acad Sci. 2011 Apr;1225:59-71
references: 21534993
references: PLoS One. 2010 Jul 28;5(7):e11751
references: 20676367
references: Soc Neurosci. 2008;3(2):97-112
references: 18633852
references: Front Hum Neurosci. 2013 Aug 16;7:467
references: 23966929
references: Dev Psychopathol. 2008 Fall;20(4):1053-80
references: 18838031
references: Cognition. 1985 Oct;21(1):37-46
references: 2934210
references: Aust N Z J Psychiatry. 2009 May;43(5):438-45
references: 19373705
references: Neurology. 2012 Apr 24;78(17):1354-62
references: 22529204
references: Neuroscientist. 2012 Aug;18(4):373-85
references: 21670424
references: Biol Psychiatry. 2009 Jan 1;65(1):63-74
references: 18996505
references: Schizophr Bull. 2011 Sep;37(5):1048-56
references: 20185539
references: J Neurosci. 2010 Mar 10;30(10):3739-44
references: 20220007
references: Soc Cogn Affect Neurosci. 2014 Sep;9(9):1253-60
references: 23887813
references: Neuroimage. 2004 Mar;21(3):1155-66
references: 15006682