title: Behavioral and neuroplastic effects of low-frequency rTMS of the unaffected hemisphere in a chronic stroke patient: a concomitant TMS and fMRI study.
abstract: Repetitive Transcranial Magnetic Stimulation (rTMS) ameliorates motor and neuropsychological deficits following stroke, but little is known about the underlying neuroplasticity. We investigated neuroplastic changes following 5 days of low-frequency rTMS on the intact motor cortex to promote motor recovery in a chronic patient with subcortical stroke. The feasibility of administering multiple treatments was also assessed 6 months later by applying the same protocol over the patient's parietal cortex to improve visuospatial disorders. Behavioral improvements and no adverse events were observed. Neuroimaging findings indicated that motor symptoms amelioration was associated with downregulation and cortical reorganization of hyperactive contralesional hemisphere.
authors: a Department of Psychology , University of Turin , Turin , Italy.
authors: Adriana
authors: A
authors: Salatino
authors: Eliana
authors: E
authors: Berra
authors: Walter
authors: W
authors: Troni
authors: Katiuscia
authors: K
authors: Sacco
authors: Franco
authors: F
authors: Cauda
authors: Federico
authors: F
authors: D'Agata
authors: Giuliano
authors: G
authors: Geminiani
authors: Sergio
authors: S
authors: Duca
authors: Ugo
authors: U
authors: Dimanico
authors: Raffaella
authors: R
authors: Ricci
mesh_terms: D001931:Brain Mapping; D002908:Chronic Disease; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010296:Parietal Lobe / Q000503:physiopathology; D020521:Stroke / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation; D014794:Visual Fields / Q000502:physiology*
keywords: Functional MRI; Motor recovery; Stroke; Visual attention; rTMS