title: Pharmaceutically active secondary metabolites of marine actinobacteria.
abstract: Marine actinobacteria are one of the most efficient groups of secondary metabolite producers and are very important from an industrial point of view. Many representatives of the order Actinomycetales are prolific producers of thousands of biologically active secondary metabolites. Actinobacteria from terrestrial sources have been studied and screened since the 1950s, for many important antibiotics, anticancer, antitumor and immunosuppressive agents. However, frequent rediscovery of the same compounds from the terrestrial actinobacteria has made them less attractive for screening programs in the recent years. At the same time, actinobacteria isolated from the marine environment have currently received considerable attention due to the structural diversity and unique biological activities of their secondary metabolites. They are efficient producers of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, antitumor, cytotoxic, cytostatic, anti-inflammatory, anti-parasitic, anti-malaria, antiviral, antioxidant, anti-angiogenesis, etc. In this review, an evaluation is made on the current status of research on marine actinobacteria yielding pharmaceutically active secondary metabolites. Bioactive compounds from marine actinobacteria possess distinct chemical structures that may form the basis for synthesis of new drugs that could be used to combat resistant pathogens. With the increasing advancement in science and technology, there would be a greater demand for new bioactive compounds synthesized by actinobacteria from various marine sources in future.
authors: Marine Biotechnology Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Panchanathan
authors: P
authors: Manivasagan
authors: Marine Biotechnology Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Jayachandran
authors: J
authors: Venkatesan
authors: Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
authors: Kannan
authors: K
authors: Sivakumar
authors: Marine Biotechnology Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: sknkim@pknu.ac.kr.
authors: Se-Kwon
authors: SK
authors: Kim
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D059001:Aquatic Organisms / Q000737:chemistry; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology*; D035843:Biomedical Research / Q000639:trends; D055808:Drug Discovery / Q000639:trends; D064210:Secondary Metabolism
chemical_list: D001688:Biological Products
keywords: Antibiotics; Bioactive compounds; Marine actinobacteria; Secondary metabolites