title: Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study.
abstract: The purpose of this study is to evaluate how beverages containingLactobacillus caseiShirota (BLS) and soy isoflavone consumption since adolescence affected the incidence of breast cancer. In a population-based case-control study, three hundred and six cases with breast cancer and 662 controls aged 40 to 55 were matched for age and residential area and included in the analyses. Diet, lifestyle and other breast cancer risk factors were investigated using the self-administered questionnaire and interview. Odds ratios (ORs) of BLS and soy isoflavone consumption for breast cancer incidence were independently and jointly estimated using a conditional logistic regression. The ORs of BLS consumption (≥ four times a week against < four times a week) was 0.65 and statistically significant (p = 0.048). The analysis of association between soy consumption and breast cancer incidence showed the more the isoflavone consumption is, the lower the odds of breast cancer becomes. Adjusted ORs for breast cancer in the second, the third and the fourth quartiles of soy consumption against the first quartile were 0.76, 0.53 and 0.48, respectively (trend test, p = 0.0002). The BLS-isoflavone interaction was not statistically significant; however, a biological interaction was suggested. Regular consumption of BLS and isoflavones since adolescence was inversely associated with the incidence of breast cancer in Japanese women.
authors: Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongou, Bunkyo-ku, Tokyo, 113-0033 Japan.
authors: Masakazu
authors: M
authors: Toi
authors: Saya
authors: S
authors: Hirota
authors: Ai
authors: A
authors: Tomotaki
authors: Nobuaki
authors: N
authors: Sato
authors: Yasuo
authors: Y
authors: Hozumi
authors: Keisei
authors: K
authors: Anan
authors: Takeshi
authors: T
authors: Nagashima
authors: Yutaka
authors: Y
authors: Tokuda
authors: Norikazu
authors: N
authors: Masuda
authors: Shozo
authors: S
authors: Ohsumi
authors: Shinji
authors: S
authors: Ohno
authors: Masato
authors: M
authors: Takahashi
authors: Hironori
authors: H
authors: Hayashi
authors: Seiichiro
authors: S
authors: Yamamoto
authors: Yasuo
authors: Y
authors: Ohashi
keywords: Breast cancer; Lactobacillus casei Shirota; probiotic beverage; soy isoflavones.
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