title: Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients.
abstract: BACKGROUND
  Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC.
  
  
  METHODS
  A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer's V coefficient.
  
  
  RESULTS
  Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109).
  
  
  CONCLUSIONS
  More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients.
authors: Department of Gastrointestinal Surgery, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, 67 West Dongchang Road, Liaocheng, Shandong Province 252000, China. yujxsd@hotmail.com
authors: Junxiu
authors: J
authors: Yu
authors: Bo
authors: B
authors: Fu
authors: Qi
authors: Q
authors: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D002681:China / Q000453:epidemiology; D003110:Colonic Neoplasms / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D055815:Young Adult
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