title: Amylin receptor: a common pathophysiological target in Alzheimer's disease and diabetes mellitus.
abstract: Amylin (islet amyloid polypeptide) and amyloid-beta (Aβ) protein, which are deposited within pancreatic islets of diabetics and brains of Alzheimer's patients respectively, share many biophysical and physiological properties. Emerging evidence indicates that the amylin receptor is a putative target receptor for the actions of human amylin and Aβ in the brain. The amylin receptor consists of the calcitonin receptor dimerized with a receptor activity-modifying protein and is widely distributed within central nervous system. Both amylin and Aβ directly activate this G protein-coupled receptor and trigger multiple common intracellular signal transduction pathways that can culminate in apoptotic cell death. Moreover, amylin receptor antagonists can block both the biological and neurotoxic effects of human amylin and Aβ. Amylin receptors thus appear to be involved in the pathophysiology of Alzheimer's disease and diabetes, and could serve as a molecular link between the two conditions that are associated epidemiologically.
authors: Division of Neurology, Department of Medicine, Centre for Neuroscience, University of Alberta , Edmonton, AB , Canada.
authors: Wen
authors: W
authors: Fu
authors: Aarti
authors: A
authors: Patel
authors: Jack H
authors: JH
authors: Jhamandas
keywords: Alzheimer’s disease; amylin; amylin receptor; amyloid-beta protein; type-2 diabetes mellitus
references: Adv Protein Chem Struct Biol. 2010;79:89-125
references: 20621282
references: J Neurosci. 2012 Nov 28;32(48):17401-6
references: 23197731
references: Cell Mol Life Sci. 2012 Jun;69(12):1947-65
references: 22193913
references: J Biol Chem. 2009 Jul 10;284(28):18742-53
references: 19406747
references: Curr Alzheimer Res. 2007 Apr;4(2):147-52
references: 17430239
references: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7
references: 12634421
references: J Neurochem. 1993 Dec;61(6):2330-3
references: 8245987
references: J Neurophysiol. 2003 Jun;89(6):2923-30
references: 12611974
references: Lancet. 2011 Mar 19;377(9770):1019-31
references: 21371747
references: FEBS Lett. 2008 Jun 25;582(15):2188-94
references: 18486611
references: Ann Neurol. 2013 Oct;74(4):517-26
references: 23794448
references: J Neurosci. 2004 Jun 16;24(24):5579-84
references: 15201330
references: Cell. 2012 Mar 16;148(6):1188-203
references: 22424229
references: N Engl J Med. 2000 Aug 10;343(6):411-9
references: 10933741
references: Physiol Rev. 2011 Jul;91(3):795-826
references: 21742788
references: Curr Alzheimer Res. 2009 Jun;6(3):213-23
references: 19519303
references: Neurobiol Aging. 2006 Feb;27(2):190-8
references: 16399206
references: Science. 2009 Jul 17;325(5938):328-32
references: 19541956
references: Neurobiol Aging. 2010 Feb;31(2):224-43
references: 18479783
references: FEBS Lett. 2013 Apr 17;587(8):1119-27
references: 23337872
references: Science. 2002 Jul 19;297(5580):353-6
references: 12130773
references: J Alzheimers Dis. 2005 Feb;7(1):63-80
references: 15750215
references: Endocrinology. 2000 Feb;141(2):850-3
references: 10650969
references: J Neural Transm (Vienna). 1998;105(4-5):423-38
references: 9720972
references: Science. 1986 Jun 27;232(4758):1612-9
references: 3086978
references: Adv Pharmacol. 2005;52:47-65
references: 16492540
references: Neurobiol Aging. 2006 Sep;27(9):1250-7
references: 16183170
references: Regul Pept. 2003 Mar 28;111(1-3):55-60
references: 12609749
references: Cell Mol Life Sci. 2009 Apr;66(8):1321-5
references: 19266159
references: Am J Pathol. 2011 Jan;178(1):140-9
references: 21224052
references: Proteomics. 2010 Apr;10(8):1621-33
references: 20186753
references: Int J Biochem Cell Biol. 2009 Mar;41(3):516-20
references: 18793745
references: Science. 2003 Apr 18;300(5618):486-9
references: 12702875
references: Endocr Rev. 2008 May;29(3):303-16
references: 18314421
references: Biogerontology. 2010 Aug;11(4):513-22
references: 20186480
references: Curr Alzheimer Res. 2006 Feb;3(1):71-3
references: 16472206
references: J Alzheimers Dis. 2010;20(3):723-36
references: 20413862
references: J Cell Mol Med. 2011 Sep;15(9):1807-21
references: 21435176
references: Endocrinology. 1999 Jun;140(6):2924-7
references: 10342886
references: Arch Neurol. 2009 Mar;66(3):306-10
references: 19273748
references: Science. 1997 Jan 31;275(5300):630-1
references: 9019820
references: Proc Natl Acad Sci U S A. 1987 Dec;84(23):8628-32
references: 3317417
references: J Biol Chem. 2012 May 25;287(22):18820-30
references: 22500019
references: Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6557-8
references: 20385830
references: J Neurochem. 2009 Dec;111(6):1490-500
references: 19811608