title: Role of endothelial cell metabolism in vessel sprouting.
abstract: Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis. Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and proliferating stalk cells that elongate the sprout. Past studies have identified genetic signals that control vascular branching. Prominent are VEGF, activating tip cells, and Notch, which stimulates stalk cells. After the branch is formed and perfused, ECs become quiescent phalanx cells. Now, emerging evidence has accumulated indicating that ECs not only adapt their metabolism when switching from quiescence to sprouting but also that metabolism regulates vascular sprouting in parallel to the control by genetic signals.
authors: Department of Oncology, University of Leuven, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Leuven 3000, Belgium; VIB, Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Leuven 3000, Belgium.
authors: Katrien
authors: K
authors: De Bock
authors: Maria
authors: M
authors: Georgiadou
authors: Peter
authors: P
authors: Carmeliet
mesh_terms: D019069:Cell Respiration; D042783:Endothelial Cells / Q000378:metabolism*; D025461:Feedback, Physiological; D006801:Humans; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000378:metabolism; D018919:Neovascularization, Physiologic