title: Human papillomavirus-associated balanoposthitis--a marker for penile intraepithelial neoplasia?
abstract: The purpose of this study was to analyse, among men treated with diathermy, whether there was a difference in balanoposthitis between men with histopathologically benign human papillomavirus-associated lesions and those with penile intraepithelial neoplasia. Data were derived from patient material from a previously published study. Two clinically identical lesions from the same genital site were collected for analysis with routine histopathology and with nested PCR. In total, 292 men were included, of which 47 (16%) had penile intraepithelial neoplasia. Of those with penile intraepithelial neoplasia, 19/47 (40%) reported problems consistent with balanoposthitis, compared with only 15/245 (6%) patients with benign lesions (p < 0.0001). A statistical difference in percentage distribution was also seen regarding morphology (p = 0.001) and location (p = 0.0003) of the lesions among the men having benign lesions with and without balanoposthitis. It is not possible to take biopsies from patients with genital warts, but this study suggests that one probably should be more observant for genital dysplasia among those men with warts with a history of balanoposthitis than those with no such history.
authors: Department of Dermatology & Venereology, Karolinska Hospital and Institute of Medicine, Karolinska Institute, Stockholm, Sweden.
authors: Arne
authors: A
authors: Wikström
authors: Mari-Anne
authors: MA
authors: Hedblad
authors: Stina
authors: S
authors: Syrjänen
mesh_terms: D003218:Condylomata Acuminata / Q000150:complications*; D004279:DNA, Viral / Q000032:analysis; D003972:Diathermy; D006801:Humans; D008297:Male; D008875:Middle Aged; D021141:Nucleic Acid Amplification Techniques; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology / Q000628:therapy / Q000821:virology*; D010409:Penile Diseases / Q000150:complications / Q000473:pathology; D010412:Penile Neoplasms / Q000150:complications / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies
chemical_list: D004279:DNA, Viral
keywords: Balanoposthitis; HPV; PIN; balanitis; condyloma; genital warts; human papillomavirus; nested PCR; penile cancer; penile intraepithelial neoplasia; sexually transmitted infection