title: Glucocorticoid-induced normotensive scleroderma renal crisis: a report on two cases and a review of the literature in Japan.
abstract: We herein report the findings of 2 cases of normotensive scleroderma renal crisis (SRC) that developed soon after the commencement of a glucocorticoid therapy. We also review 8 cases of normotensive SRC reported in Japan, including our cases. The common characteristics of these 8 cases are as follows: the recent onset of systemic sclerosis, the presence of diffuse skin sclerosis, the presence of myositis and/or serositis, a high titer of antinuclear antibody and positivity for anti-Scl-70 antibody. In 7 of the 8 patients, thrombotic microangiopathy developed within one month of starting the glucocorticoid treatment. We should be careful with the use of glucocorticoids in systemic sclerosis patients exhibiting these features in order to avoid cases of normotensive SRC.
authors: Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan.
authors: Akihito
authors: A
authors: Maruyama
authors: Takao
authors: T
authors: Nagashima
authors: Kohei
authors: K
authors: Ikenoya
authors: Yoko
authors: Y
authors: Aoki
authors: Yasushi
authors: Y
authors: Matsuyama
authors: Masahiro
authors: M
authors: Iwamoto
authors: Seiji
authors: S
authors: Minota
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis* / Q000453:epidemiology; D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D005938:Glucocorticoids