title: Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis.
abstract: BACKGROUND
  Several randomized controlled trials (RCTs) have compared endoscopic and symptomatic relapses in patients with erosive gastroesophageal reflux disease (GERD). We have summarized current evidence for rabeprazole 10 or 20 mg once daily for GERD maintenance treatment over 1 or 5 years.
  
  
  METHODS
  MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched, through August 2012, for eligible RCTs of adults with erosive GERD. The efficacies of rabeprazole 10 and 20 mg/d were compared.
  
  
  RESULTS
  The search identified 288 citations, and five RCTs containing 1480 patients were considered eligible. Heartburn relapse rates did not differ significantly between patients treated with rabeprazole 10 and 20 mg/d for 1 year (relative risk (RR) = 1.29; 95% confidence interval (CI): 0.97-1.72), but differed in patients treated for 5 years (RR = 1.274; 95% CI: 1.005-1.615). Endoscopic relapse rates differed significantly between rabeprazole 10 and 20 mg/d for 1 year (RR = 1.92; 95% CI: 1.21-3.06), for 5 years (RR = 1.667; 95% CI: 1.073-2.589), and in combined 1- and 5-year maintenance trials (RR = 1.785; 95% CI: 1.298-2.456).
  
  
  CONCLUSIONS
  Rabeprazole 20 mg/d was superior to rabeprazole 10 mg/d in preventing endoscopic relapse of erosive GERD, but that the two dosages were equivalent in symptomatic relief over 1 year.
authors: Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors: Hai-di
authors: HD
authors: Zhu
authors: Heng
authors: H
authors: Wang
authors: Xian-ming
authors: XM
authors: Xia
authors: Shu-man
authors: SM
authors: Xu
authors: Yao
authors: Y
authors: Lan
mesh_terms: D004305:Dose-Response Relationship, Drug; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D064750:Rabeprazole / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence
chemical_list: D054328:Proton Pump Inhibitors; D064750:Rabeprazole