title: Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report.
abstract: Combined large cell neuroendocrine carcinoma of the lungs (combined LCNEC) with giant cell carcinoma is extremely rare. A 65-year-old man was found to have an abnormal shadow in his left lung field. Computed tomography revealed a solid, round mass measuring 2.8 × 2.2 cm that was located in the left S9. The patient underwent left lower lobectomy and mediastinal lymph node dissection. Histopathological examination revealed an LCNEC, combined with giant cell carcinoma. The patient received by S-1 (TS-1, an oral fluoropyrimidine) chemotherapy, and he has been disease-free for over 8 months. Combined LCNEC with giant cell carcinoma is an extremely rare tumor with high malignant potential, and thus, multidisciplinary therapy and close follow-up are advised.
authors: Respiratory Center, Asahikawa Medical University Hospital, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, Japan. shayashi@asahikawa-med.ac.jp
authors: Satoshi
authors: S
authors: Hayashi
authors: Masahiro
authors: M
authors: Kitada
authors: Kei
authors: K
authors: Ishibashi
authors: Yoshinari
authors: Y
authors: Matsuda
authors: Naoyuki
authors: N
authors: Miyokawa
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018286:Carcinoma, Giant Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D018287:Carcinoma, Large Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D011379:Prognosis; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
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