title: Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13).
abstract: The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.
authors: Department of Neurological Surgery, University of New Mexico, Albuquerque, New Mexico.
authors: Andrew P
authors: AP
authors: Carlson
authors: Howard
authors: H
authors: Yonas
authors: Garth T
authors: GT
authors: Olson
authors: Kaaren K
authors: KK
authors: Reichard
authors: Rafael
authors: R
authors: Medina-Flores
keywords: Chondroblastoma; cytogenetics; genetics; karyotype; skull-base tumor; temporal bone
references: Ann Otol Rhinol Laryngol. 1992 Sep;101(9):763-9
references: 1514755
references: J Am Acad Dermatol. 1999 Feb;40(2 Pt 2):325-7
references: 10025860
references: Childs Nerv Syst. 2007 Feb;23(2):231-5
references: 17115228
references: Hum Pathol. 2000 Mar;31(3):306-11
references: 10746672
references: Int J Cancer. 1995 Aug 9;62(4):398-402
references: 7635565
references: Neuroradiology. 1986;28(4):367-70
references: 3762919
references: Eur Arch Otorhinolaryngol. 2008 Dec;265(12):1447-54
references: 18401591
references: Cancer Genet Cytogenet. 1998 Jul 1;104(1):52-6
references: 9648559
references: J Oral Maxillofac Surg. 2002 Feb;60(2):198-203
references: 11815922
references: Neurosurgery. 1988 Jun;22(6 Pt 1):1102-7
references: 3047595
references: Mod Pathol. 1998 Nov;11(11):1071-4
references: 9831204
references: Cancer Genet Cytogenet. 2009 Jul 15;192(2):56-9
references: 19596254
references: Neurol India. 2002 Dec;50(4):534-6
references: 12577121
references: J Bone Joint Surg Am. 1975 Apr;57(3):418-20
references: 1123399
references: J Laryngol Otol. 1996 Jul;110(7):696-9
references: 8759554
references: Clin Orthop Relat Res. 1998 Apr;(349):189-93
references: 9584382
references: J Pathol. 2002 Feb;196(2):194-203
references: 11793371
references: Mod Pathol. 2008 Nov;21(11):1303-10
references: 18587326
references: Surg Neurol. 2005 Mar;63(3):265-8; discussion 268
references: 15734522
references: Diagn Cytopathol. 2008 Dec;36(12):868-75
references: 18925568
references: Otol Neurotol. 2009 Aug;30(5):688-9
references: 19339910
references: Br J Oral Surg. 1980 Sep;18(2):150-6
references: 6934807
references: Surg Neurol. 1985 Jul;24(1):52-6
references: 4012561
references: Neurol Med Chir (Tokyo). 2002 Nov;42(11):516-20
references: 12472218
references: AJNR Am J Neuroradiol. 1993 Jan-Feb;14(1):70-1
references: 8427113
references: Arch Pathol Lab Med. 2005 Apr;129(4):539-40
references: 15794684
references: Laryngoscope. 2007 May;117(5):848-53
references: 17473681
references: Brain Pathol. 2007 Jul;17(3):327-8
references: 17598827
references: J Laryngol Otol. 1994 Dec;108(12):1115-9
references: 7861099
references: Br J Oral Maxillofac Surg. 1987 Jun;25(3):250-5
references: 3474023
references: Diagn Cytopathol. 2006 Jun;34(6):424-9
references: 16680777
references: Cancer Genet Cytogenet. 1992 Jan;58(1):14-7
references: 1728944
references: Acta Neurochir (Wien). 2002 Dec;144(12):1315-8
references: 12478344
references: Am J Clin Pathol. 1987 Jul;88(1):1-9
references: 3604981
references: J Korean Med Sci. 1999 Oct;14(5):559-64
references: 10576153
references: Am J Otolaryngol. 2003 Nov-Dec;24(6):370-3
references: 14608568
references: Cancer Genet Cytogenet. 1998 Sep;105(2):109-12
references: 9723025
references: Pathol Int. 1994 Dec;44(12):857-9
references: 7866569
references: Skeletal Radiol. 1991;20(4):299-301
references: 1853225
references: Int J Oncol. 2004 Jun;24(6):1385-91
references: 15138578
references: Int J Surg Pathol. 2003 Apr;11(2):137-41
references: 12754636
references: Hum Pathol. 2006 Jul;37(7):890-8
references: 16784990
references: Neuropathology. 2005 Jun;25(2):159-64
references: 15875910
references: Skull Base Surg. 1999;9(4):301-5
references: 17171120
references: Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):1017-24
references: 11958897
references: Otolaryngol Head Neck Surg. 1990 Mar;102(3):264-9
references: 2108415
references: BMC Cancer. 2009 Nov 10;9:393
references: 19903358
references: Curr Opin Oncol. 2004 Jul;16(4):342-54
references: 15187889
references: Cancer Genet Cytogenet. 1993 Sep;69(2):79-90
references: 8402563
references: Cranio. 2004 Apr;22(2):160-8
references: 15134417
references: No To Shinkei. 1992 Feb;44(2):143-8
references: 1567733