title: Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs.
abstract: Quantitative contrast enhanced ultrasound is a major breakthrough for ultrasound imaging in recent years. However, contrast enhancement of the pancreas is brief with bolus injection. To assess if continuous infusion of Sonazoid(®) can prolong the duration of pancreatic enhancement over bolus injections, eight adult dogs received bolus injection and continuous infusion of Sonazoid(®) on separate days. Contrast enhanced ultrasound of the pancreatic parenchyma and proximal descending duodenum was performed, and time intensity curves reflecting tissue perfusions were generated. Perfusion parameters- time to initial upslope, peak time, time to wash-out and peak intensity were calculated and evaluated. Fast wash-in to intense peak, followed by rapid wash-out was observed for time intensity curves of bolus injection. With continuous infusion, contrast wash-in to peak intensity was gradual, followed by long plateau and slow wash-out. Median contrast enhancement durations of the pancreas and duodenum were significantly prolonged by continuous infusion from 11 sec (range, 10 to 23 sec) and 16 sec (range, 3 to 43 sec) at bolus injection to 205 sec (range, 170 to 264 sec, P<0.01) and 193 sec (range, 169 to 216 sec, P<0.05), respectively. Median peak intensity of the pancreas was 100.9 MPV (range, 80.2 to 124.3 MPV) at bolus injection and 77.6 MPV (range, 58.2 to 99.5 MPV, P<0.05) at continuous infusion. Prolonged continuous imaging is afforded by continuous infusion of contrast agent. Peak intensity of the pancreas was slightly diminished in continuous infusion, but offered adequate imaging subjectively.
authors: Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan.
authors: Sue Yee
authors: SY
authors: Lim
authors: Kensuke
authors: K
authors: Nakamura
authors: Keitaro
authors: K
authors: Morishita
authors: Noboru
authors: N
authors: Sasaki
authors: Masahiro
authors: M
authors: Murakami
authors: Tatsuyuki
authors: T
authors: Osuga
authors: Hiroshi
authors: H
authors: Ohta
authors: Masahiro
authors: M
authors: Yamasaki
authors: Mitsuyoshi
authors: M
authors: Takiguchi
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004285:Dogs; D005290:Ferric Compounds; D007262:Infusions, Intravenous; D007267:Injections; D007501:Iron; D010087:Oxides; D010179:Pancreas / Q000000981:diagnostic imaging*; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods* / Q000662:veterinary*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron
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