title: Quantitative evaluation of hyperbaric oxygen efficacy in experimental traumatic brain injury: an MRI study.
abstract: To use DCE-magnetic resonance imaging (MRI) and diffusion-weighted imaging to evaluate the hyperbaric oxygen efficacy (HBO) in experimental traumatic brain injury (TBI). Forty-two rabbits were randomly divided into four groups: TBI, TBI + HBO, sham group, sham + HBO. The TBI + HBO and sham + HBO received a total of 10 HBO treatments within 7 days following TBI, and MRI was performed within a month after TBI. Functional assessments were performed pre-TBI, and at 1 and 30 days. In focal lesion area, K(trans) in TBI + HBO group was lower than TBI group at both acute and subacute phase (p < 0.05). ADC was higher in TBI + HBO group than TBI group at acute phase (p < 0.01), but lower at subacute phase (p < 0.05). In perifocal area, K(trans) were lower in TBI + HBO group than TBI group at acute phase (p < 0.01) after TBI. ADC was lower in the TBI + HBO group than in the TBI group at both acute and subacute phase (p < 0.01).The VCS was higher in TBI + HBO group than TBI group at 30 days (p < 0.05). HBO could improve the impaired BBB and cytotoxic edema after TBI and promote the recovery of neurofunction.
authors: Department of Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai, 200233, China.
authors: Xiao-Er
authors: XE
authors: Wei
authors: Yue-Hua
authors: YH
authors: Li
authors: Hui
authors: H
authors: Zhao
authors: Ming-Hua
authors: MH
authors: Li
authors: Min
authors: M
authors: Fu
authors: Wen-Bin
authors: WB
authors: Li
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging; D006931:Hyperbaric Oxygenation; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D009460:Neurologic Examination; D011817:Rabbits; D011897:Random Allocation; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
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