title: EURRECA-Estimating zinc requirements for deriving dietary reference values.
abstract: Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide, and the public health concern is considerable. In accordance with the EURRECA consortium principles and protocols, a series of literature reviews were undertaken in order to develop best practice guidelines for assessing dietary zinc intake and zinc status. These were incorporated into subsequent literature search strategies and protocols for studies investigating the relationships between zinc intake, status and health, as well as studies relating to the factorial approach (including bioavailability) for setting dietary recommendations. EMBASE (Ovid), Cochrane Library CENTRAL, and MEDLINE (Ovid) databases were searched for studies published up to February 2010 and collated into a series of Endnote databases that are available for the use of future DRV panels. Meta-analyses of data extracted from these publications were performed where possible in order to address specific questions relating to factors affecting dietary recommendations. This review has highlighted the need for more high quality studies to address gaps in current knowledge, in particular the continued search for a reliable biomarker of zinc status and the influence of genetic polymorphisms on individual dietary requirements. In addition, there is a need to further develop models of the effect of dietary inhibitors of zinc absorption and their impact on population dietary zinc requirements.
authors: International Institute of Nutrition and Applied Food Safety Studies, University of Central Lancashire, Preston, United Kingdom. NMLowe@uclan.ac.uk
authors: Nicola M
authors: NM
authors: Lowe
authors: Fiona C
authors: FC
authors: Dykes
authors: Anna-Louise
authors: AL
authors: Skinner
authors: Sujata
authors: S
authors: Patel
authors: Marisol
authors: M
authors: Warthon-Medina
authors: Tamás
authors: T
authors: Decsi
authors: Katalin
authors: K
authors: Fekete
authors: Olga W
authors: OW
authors: Souverein
authors: Carla
authors: C
authors: Dullemeijer
authors: Adriënne E
authors: AE
authors: Cavelaars
authors: Lluis
authors: L
authors: Serra-Majem
authors: Mariela
authors: M
authors: Nissensohn
authors: Silvia
authors: S
authors: Bel
authors: Luis A
authors: LA
authors: Moreno
authors: Maria
authors: M
authors: Hermoso
authors: Christiane
authors: C
authors: Vollhardt
authors: Cristiana
authors: C
authors: Berti
authors: Irene
authors: I
authors: Cetin
authors: Mirjana
authors: M
authors: Gurinovic
authors: Romana
authors: R
authors: Novakovic
authors: Linda J
authors: LJ
authors: Harvey
authors: Rachel
authors: R
authors: Collings
authors: Victoria
authors: V
authors: Hall-Moran
mesh_terms: D001682:Biological Availability; D015415:Biomarkers / Q000097:blood; D004032:Diet; D019587:Dietary Supplements; D005060:Europe; D006801:Humans; D015201:Meta-Analysis as Topic; D015596:Nutrition Assessment; D018673:Nutrition Policy / Q000331:legislation & jurisprudence; D016032:Randomized Controlled Trials as Topic; D064167:Recommended Dietary Allowances / Q000331:legislation & jurisprudence*; D012016:Reference Values; D015032:Zinc / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D015415:Biomarkers; D015032:Zinc