title: Anticonvulsant activity of 2-(substituted-imino)thiazolidin-4-ones.
abstract: A novel series of 2-(substituted-imino)thiazolidin-4-ones were synthesized and evaluated for anticonvulsant activity using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (Sc-PTZ) assays and their neurotoxicity was measured by the rotarod test. The results of these tests demonstrated that 2-(4-(pentyloxy)phenylimino)thiazolidin-4-one (5d) was the most potent anticonvulsant, with ED50 value of 18.5 mg/kg and 15.3 mg/kg in the MES and Sc-PTZ tests, and protective index (PI=TD50/ED50) values of 10.6 and 12.8 respectively. 5d was much safer than a reference drug Carbamazepine.
authors: College of Pharmacy, Yanbian University, Yanji, China.
authors: G-H
authors: GH
authors: Gong
authors: College of Pharmacy, Yanbian University, Yanji, China.
authors: D
authors: D
authors: Wang
authors: Institute of Medicinal Chemistry and Pharmacology, Inner Mongolia University for Nationalities, Tongliao, China.
authors: J-F
authors: JF
authors: Zhang
authors: Institute of Medicinal Chemistry and Pharmacology, Inner Mongolia University for Nationalities, Tongliao, China.
authors: C-X
authors: CX
authors: Wei
authors: College of Pharmacy, Yanbian University, Yanji, China.
authors: Z-S
authors: ZS
authors: Quan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002220:Carbamazepine / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D007202:Indicators and Reagents; D053778:Thiazolidines; D002220:Carbamazepine; D010433:Pentylenetetrazole