title: A mid-life vitamin A supplementation prevents age-related spatial memory deficits and hippocampal neurogenesis alterations through CRABP-I.
abstract: Age-related memory decline including spatial reference memory is considered to begin at middle-age and coincides with reduced adult hippocampal neurogenesis. Moreover, a dysfunction of vitamin A hippocampal signalling pathway has been involved in the appearance of age-related memory deficits but also in adult hippocampal neurogenesis alterations. The present study aims at testing the hypothesis that a mid-life vitamin A supplementation would be a successful strategy to prevent age-related memory deficits. Thus, middle-aged Wistar rats were submitted to a vitamin A enriched diet and were tested 4 months later in a spatial memory task. In order to better understand the potential mechanisms mediating the effects of vitamin A supplementation on hippocampal functions, we studied different aspects of hippocampal adult neurogenesis and evaluated hippocampal CRABP-I expression, known to modulate differentiation processes. Here, we show that vitamin A supplementation from middle-age enhances spatial memory and improves the dendritic arborisation of newborn immature neurons probably resulting in a better survival and neuronal differentiation in aged rats. Moreover, our results suggest that hippocampal CRABP-I expression which controls the intracellular availability of retinoic acid (RA), may be an important regulator of neuronal differentiation processes in the aged hippocampus. Thus, vitamin A supplementation from middle-age could be a good strategy to maintain hippocampal plasticity and functions.
authors: Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France ; INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France.
authors: Katia
authors: K
authors: Touyarot
authors: Damien
authors: D
authors: Bonhomme
authors: Pascale
authors: P
authors: Roux
authors: Serge
authors: S
authors: Alfos
authors: Pauline
authors: P
authors: Lafenêtre
authors: Emmanuel
authors: E
authors: Richard
authors: Paul
authors: P
authors: Higueret
authors: Véronique
authors: V
authors: Pallet
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D019587:Dietary Supplements; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory; D008569:Memory Disorders / Q000517:prevention & control*; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism*; D014801:Vitamin A / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D018168:Receptors, Retinoic Acid; C082927:retinoic acid binding protein I, cellular; D014801:Vitamin A
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