title: The uniqueness of the plant mitochondrial potassium channel.
abstract: The ATP-inhibited Plant Mitochondrial K(+) Channel (PmitoKATP) was discovered about fifteen years ago in Durum Wheat Mitochondria (DWM). PmitoKATP catalyses the electrophoretic K(+) uniport through the inner mitochondrial membrane; moreover, the co-operation between PmitoKATP and K(+)/H(+) antiporter allows such a great operation of a K(+) cycle to collapse mitochondrial membrane potential (ΔΨ) and ΔpH, thus impairing protonmotive force (Δp). A possible physiological role of such ΔΨ control is the restriction of harmful reactive oxygen species (ROS) production under environmental/oxidative stress conditions. Interestingly, DWM lacking Δp were found to be nevertheless fully coupled and able to regularly accomplish ATP synthesis; this unexpected behaviour makes necessary to recast in some way the classical chemiosmotic model. In the whole, PmitoKATP may oppose to large scale ROS production by lowering ΔΨ under environmental/oxidative stress, but, when stress is moderate, this occurs without impairing ATP synthesis in a crucial moment for cell and mitochondrial bioenergetics.
authors: Dipartimento di Scienze Agrarie, degli Alimenti e dell'Ambiente, Università di Foggia, Via Napoli 25-71122 Foggia, Italy. d.pastore@unifg.it
authors: Donato
authors: D
authors: Pastore
authors: Mario
authors: M
authors: Soccio
authors: Maura Nicoletta
authors: MN
authors: Laus
authors: Daniela
authors: D
authors: Trono
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D015221:Potassium Channels / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014908:Triticum / Q000378:metabolism*
chemical_list: D015221:Potassium Channels; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate
references: FEBS Lett. 2010 May 17;584(10):2057-62
references: 20083113
references: Biochemistry. 1992 Mar 31;31(12):3297-302
references: 1313290
references: Biochim Biophys Acta. 2003 Sep 30;1606(1-3):23-41
references: 14507425
references: Biochem J. 1980 Jun 15;188(3):945-8
references: 6258563
references: J Biol Chem. 1992 Jul 15;267(20):13903-9
references: 1629190
references: Biochemistry. 1980 Sep 30;19(20):4615-19
references: 7426620
references: Am J Physiol. 1993 Aug;265(2 Pt 2):H453-60
references: 8368348
references: Biochem J. 2009 Nov 11;424(2):307-16
references: 19740073
references: Biochim Biophys Acta. 1997 Feb 15;1318(3):317-21
references: 9048974
references: J Exp Bot. 2011 Jan;62(1):141-54
references: 20801915
references: Biochim Biophys Acta. 2005 Sep 30;1709(3):195-202
references: 16139788
references: Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:561-591
references: 11337409
references: Biochim Biophys Acta. 1984 Dec 17;768(3-4):257-92
references: 6095906
references: Biophys J. 2002 Jun;82(6):2833-46
references: 12023208
references: J Biol Chem. 1987 Apr 15;262(11):5000-7
references: 3031035
references: Proc Natl Acad Sci U S A. 1983 Jun;80(11):3313-7
references: 6574486
references: Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H649-57
references: 11158963
references: Biochim Biophys Acta. 1995 Oct 10;1231(3):282-8
references: 7578216
references: Bioelectrochem Bioenerg. 1999 Oct;49(1):43-50
references: 10619447
references: Biochim Biophys Acta. 2003 Jun 5;1604(2):77-94
references: 12765765
references: J Exp Biol. 2000 Jan;203(Pt 1):51-9
references: 10600673
references: Biochem J. 1982 Aug 15;206(2):351-7
references: 7150247
references: Plant Physiol. 1994 Jan;104(1):171-178
references: 12232070
references: Biochem Biophys Res Commun. 1995 May 5;210(1):98-104
references: 7741755
references: Biol Rev Camb Philos Soc. 1966 Aug;41(3):445-502
references: 5329743
references: Plant Physiol. 1993 Jan;101(1):7-12
references: 12231660
references: J Biol Chem. 1999 Sep 17;274(38):26683-90
references: 10480870
references: Funct Plant Biol. 2006 May;33(4):357-366
references: 32689242
references: Biochim Biophys Acta. 1976 Oct 13;449(1):108-24
references: 10008
references: Anal Biochem. 2001 Nov 15;298(2):170-80
references: 11757503
references: FEBS Lett. 1984 Jan 2;165(1):1-5
references: 6319178
references: Plant Cell Physiol. 2008 Jul;49(7):1039-55
references: 18511459
references: Biochim Biophys Acta. 2011 Mar;1807(3):275-85
references: 21167126
references: Biophys J. 2003 Feb;84(2 Pt 1):1031-7
references: 12547784
references: Nature. 1994 Aug 4;370(6488):379-82
references: 8047144
references: Plant Sci. 2013 Feb;199-200:91-102
references: 23265322
references: Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):372-6
references: 7831293
references: Nature. 1961 Jul 8;191:144-8
references: 13771349
references: Arch Biochem Biophys. 1997 Oct 1;346(1):37-44
references: 9328282
references: J Bioenerg Biomembr. 2004 Apr;36(2):195-202
references: 15224969
references: Mol Microbiol. 1995 Feb;15(3):403-10
references: 7783613
references: Plant Cell Environ. 2011 Dec;34(12):2093-108
references: 21819416
references: J Biol Chem. 1992 Dec 25;267(36):26062-9
references: 1464617
references: J Plant Physiol. 2008 Sep 8;165(13):1360-9
references: 18177980
references: Biochim Biophys Acta. 2003 Dec 8;1607(2-3):111-9
references: 14670601
references: Plant Cell Rep. 2008 Jan;27(1):137-46
references: 17823801
references: J Biol Chem. 1986 Oct 25;261(30):14031-8
references: 2945814
references: EMBO J. 1999 Aug 2;18(15):4118-27
references: 10428951
references: Biochim Biophys Acta. 1991 Nov 4;1069(2):131-8
references: 1718429
references: Biochemistry. 1994 Nov 22;33(46):13684-92
references: 7947777
references: Plant Cell Physiol. 2001 Dec;42(12):1373-82
references: 11773530
references: Cell Physiol Biochem. 2010;26(6):975-82
references: 21220928
references: J Exp Bot. 2007;58(2):195-210
references: 17261694
references: Biochim Biophys Acta. 1996 Jul 18;1275(1-2):123-6
references: 8688444
references: J Bioenerg Biomembr. 1997 Dec;29(6):579-90
references: 9559859