title: Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up.
abstract: In experimental studies, mesenchymal stem cell (MSC) transplantation in acute myocardial infarction (AMI) models has been associated with enhanced neovascularization and myogenesis. Clinical data however, are scarce. Therefore, the present study evaluates the safety and feasibility of intramyocardial MSC injection in nine patients, shortly after AMI during short-term and 5-year follow-up. Periprocedural safety analysis demonstrated one transient ischemic attack. No other adverse events related to MSC treatment were observed during 5-year follow-up. Clinical events were compared to a nonrandomized control group comprising 45 matched controls. A 5-year event-free survival after MSC-treatment was comparable to controls (89 vs. 91 %, P = 0.87). Echocardiographic imaging for evaluation of left ventricular function demonstrated improvements up to 5 years after MSC treatment. These findings were not significantly different when compared to controls. The present safety and feasibility study suggest that intramyocardial injection of MSC in patients shortly after AMI is feasible and safe up to 5-year follow-up.
authors: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333, Post office box 9600, 2300, RC, Leiden, The Netherlands.
authors: Sander F
authors: SF
authors: Rodrigo
authors: Jan
authors: J
authors: van Ramshorst
authors: Georgette E
authors: GE
authors: Hoogslag
authors: Helèn
authors: H
authors: Boden
authors: Matthijs A
authors: MA
authors: Velders
authors: Suzanne C
authors: SC
authors: Cannegieter
authors: Helene
authors: H
authors: Roelofs
authors: Imad
authors: I
authors: Al Younis
authors: Petra
authors: P
authors: Dibbets-Schneider
authors: Willem E
authors: WE
authors: Fibbe
authors: Jaap Jan
authors: JJ
authors: Zwaginga
authors: Jeroen J
authors: JJ
authors: Bax
authors: Martin J
authors: MJ
authors: Schalij
authors: Saskia L
authors: SL
authors: Beeres
authors: Douwe E
authors: DE
authors: Atsma
mesh_terms: D000368:Aged; D049109:Cell Proliferation; D002469:Cell Separation; D002478:Cells, Cultured; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007267:Injections; D053208:Kaplan-Meier Estimate; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D020127:Recovery of Function; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D016277:Ventricular Function, Left
references: Circulation. 2005 Jul 12;112(2):214-23
references: 15998673
references: JAMA. 2009 May 20;301(19):1997-2004
references: 19454638
references: Circulation. 2010 Dec 7;122(23):2419-29
references: 21098445
references: Circ Res. 2011 Aug 5;109(4):428-36
references: 21737787
references: J Clin Invest. 1999 Mar;103(5):697-705
references: 10074487
references: Cell Transplant. 2007;16(9):963-70
references: 18293895
references: Cell Transplant. 2012;21(8):1697-709
references: 22410280
references: Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11474-9
references: 16061805
references: Circulation. 2005 Aug 30;112(9 Suppl):I150-6
references: 16159808
references: Eur Heart J. 2000 Aug;21(16):1387-96
references: 10952828
references: Eur Heart J. 2007 Dec;28(24):2998-3005
references: 17984132
references: J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86
references: 19958962
references: Circulation. 2002 Jan 1;105(1):93-8
references: 11772882
references: Catheter Cardiovasc Interv. 2005 Jul;65(3):321-9
references: 15954106
references: J Intern Med. 2007 Nov;262(5):509-25
references: 17949362
references: Stem Cells. 2006 Sep;24(9):2052-9
references: 16728560
references: Am J Cardiol. 2006 Mar 15;97(6):823-9
references: 16516583
references: Circulation. 2004 Feb 10;109(5):656-63
references: 14734516
references: Nat Clin Pract Cardiovasc Med. 2008 Oct;5(10):663-70
references: 18711405
references: Eur J Heart Fail. 2009 Sep;11(9):887-96
references: 19654139
references: J Nucl Med. 2006 Apr;47(4):574-80
references: 16595489
references: Am Heart J. 2007 Jan;153(1):14.e1-11
references: 17174628
references: Eur Heart J. 2007 Nov;28(21):2667-77
references: 17933755
references: J Mol Cell Cardiol. 2007 Apr;42(4):735-45
references: 17320899
references: Blood. 2006 Sep 15;108(6):2114-20
references: 16690970
references: Heart. 2009 Jul;95(14):1145-52
references: 19336430
references: Circulation. 2005 Jan 18;111(2):150-6
references: 15642764
references: Am J Cardiol. 2012 Jan 15;109(2):187-94
references: 22244127
references: Am J Cardiol. 2004 Jul 1;94(1):92-5
references: 15219514
references: Circulation. 2012 Jul 31;126(5):551-68
references: 22730444
references: Lancet. 2004 Mar 6;363(9411):783-4
references: 15016490
references: Circ Res. 2011 Apr 1;108(7):792-6
references: 21415390
references: Lancet. 2008 May 10;371(9624):1579-86
references: 18468541
references: Eur J Immunol. 2006 Oct;36(10):2566-73
references: 17013987
references: Cytotherapy. 2006;8(4):315-7
references: 16923606
references: J Surg Res. 2009 May 15;153(2):217-23
references: 18694573
references: Coron Artery Dis. 2005 Mar;16(2):93-7
references: 15735401
references: Lancet. 2003 Jan 4;361(9351):47-9
references: 12517468
references: J Am Coll Cardiol. 2007 Oct 16;50(16):1532-40
references: 17936151