title: Structure-function-property-design interplay in biopolymers: spider silk.
abstract: Spider silks have been a focus of research for almost two decades due to their outstanding mechanical and biophysical properties. Recent advances in genetic engineering have led to the synthesis of recombinant spider silks, thus helping to unravel a fundamental understanding of structure-function-property relationships. The relationships between molecular composition, secondary structures and mechanical properties found in different types of spider silks are described, along with a discussion of artificial spinning of these proteins and their bioapplications, including the role of silks in biomineralization and fabrication of biomaterials with controlled properties.
authors: Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
authors: Olena
authors: O
authors: Tokareva
authors: Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
authors: Matthew
authors: M
authors: Jacobsen
authors: Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors: Markus
authors: M
authors: Buehler
authors: Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
authors: Joyce
authors: J
authors: Wong
authors: Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: David.Kaplan@tufts.edu.
authors: David L
authors: DL
authors: Kaplan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001696:Biomechanical Phenomena / Q000187:drug effects; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D047011:Silk / Q000737:chemistry* / Q000494:pharmacology*; D013112:Spiders / Q000033:anatomy & histology / Q000737:chemistry* / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D001672:Biocompatible Materials; D047011:Silk
keywords: Genetic engineering; Proteins; Secondary structure; Self-assembly; Spider silk
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