title: Urinary inositol phosphoglycan-P type: near patient test to detect preeclampsia prior to clinical onset of the disease. A study on 416 pregnant Mauritian women.
abstract: Preeclampsia and eclampsia account for major pregnancy complications in Mauritius, an emerging country (maternal mortality rate of 60 per 100,000 deliveries). This prospective longitudinal study was carried out in the main regional hospital in the north of the island, to measure inositol phosphoglycan-P type (IPG-P) in the urine of pregnant women (using an ELISA-based assay). Women had approximately 10 prenatal visits per pregnancy and a complete follow-up in this same referral centre after the first trimester of pregnancy. Urine samples were collected every 1-4 weeks in all women. In a cohort of 416 patients, preeclampsia (PE) was diagnosed in 34 women. In established PE (hypertension and proteinuria), the assay as a diagnostic test showed a positive likelihood ratio of 18.73, a negligible negative likelihood ratio with area under the curve (AUC) of 0.99, sensitivity of 96.7%, specificity of 94.8% and remained negative in control women (n=312), women with gestational hypertension (without proteinuria (n=56), and gestational diabetic mothers (n=14). Moreover, as a predictive screening test two weeks before the diagnosis of PE, the assay showed sensitivity of 84.2% and specificity of 83.6%. Detection of urinary inositol phosphoglycan-P type in pregnant women can be a useful confirmatory marker of PE, as well as a predictive marker, two weeks before the onset of the disease.
authors: Department of Medicine, Faculty of Science, University of Mauritius, Réduit, Mauritius. Electronic address: poonythl@uom.ac.mu.
authors: Lalita
authors: L
authors: Dawonauth
authors: Sylus Pharmaceuticals Ltd, Centre for Innovation and Enterprise, University of Oxford, Begbroke Science Park, Sandy Lane, Yarnton OX5 1PF, United Kingdom. Electronic address: laurensrademacher@syluspharma.com.
authors: Laurens
authors: L
authors: Rademacher
authors: Department of Medicine, Faculty of Science, University of Mauritius, Réduit, Mauritius. Electronic address: domiioshugoki@gmail.com.
authors: Arnaud Dominique
authors: AD
authors: L'Omelette
authors: Department of Medicine, Faculty of Science, University of Mauritius, Réduit, Mauritius. Electronic address: jankees@uom.ac.mu.
authors: Sarojini
authors: S
authors: Jankee
authors: Department of Medicine, Faculty of Science, University of Mauritius, Réduit, Mauritius. Electronic address: leekwaiy@uom.ac.mu.
authors: Man Yoon
authors: MY
authors: Lee Kwai Yan
authors: Department of Medicine, Faculty of Science, University of Mauritius, Réduit, Mauritius. Electronic address: adil.jeeawoody@gmail.com.
authors: Razgia B
authors: RB
authors: Jeeawoody
authors: Research Department of Immunology, Division of Infection and Immunity, University College London Medical School, Windeyer Building, 46 Cleveland Street, London W1P 6DB, United Kingdom. Electronic address: t.rademacher@ucl.ac.uk.
authors: Thomas W
authors: TW
authors: Rademacher
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine*; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007295:Inositol Phosphates / Q000652:urine*; D008137:Longitudinal Studies; D008403:Mass Screening; D008435:Mauritania; D019095:Point-of-Care Systems; D011134:Polysaccharides / Q000652:urine*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan
keywords: Diagnostic test; Inositol phosphoglycan-P type; Preeclampsia; Screening test; Urinary test