title: Hypersensitivity reaction to all drugs of category-1 anti-tuberculosis regime in an adult tuberculosis patient.
abstract: Adverse drug reaction to tuberculous chemotherapy is not an uncommon problem. Usually it occurs to single drug and can be treated easily with minimal intervention. We follow WHO recommended guideline for National Tuberculosis Control Programs to treat these adverse reactions. Here we found an adult who has been suffering left sided pleural tuberculosis developed anaphylactic reaction to first dose of category-1 anti-TB regime. Later on it was found that he could not even tolerate smaller challenging doses of isoniazide, Ethambutol, Rifampicin and Pyrazinamide separately. It became very difficult to choose an alternate regime for this patient. Lastly a regime with levofloxacin, streptomycin and clarithromycin was give to treat him and patient was recovered with this regime successfully. This experience will help in management of unusual drug reactions to anti-tuberculosis drugs.
authors: Dr Md Mamunur Rashid, Assistant Professor, Department of Respiratory Medicine, National Institute of Diseases of Chest and Hospital (NIDCH), Mohakhali, Dhaka, Bangladesh.
authors: M M
authors: MM
authors: Rashid
authors: M N
authors: MN
authors: Hoque
authors: D A
authors: DA
authors: Hossain
authors: M R
authors: MR
authors: Hassan
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents