title: FITC-quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells.
abstract: By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC-quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.
authors: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China. gliang@ustc.edu.cn.
authors: Anming
authors: A
authors: Tang
authors: Bin
authors: B
authors: Mei
authors: Weijuan
authors: W
authors: Wang
authors: Wanglai
authors: W
authors: Hu
authors: Fang
authors: F
authors: Li
authors: Jun
authors: J
authors: Zhou
authors: Qing
authors: Q
authors: Yang
authors: Hua
authors: H
authors: Cui
authors: Mian
authors: M
authors: Wu
authors: Gaolin
authors: G
authors: Liang
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D053148:Caspase 3 / Q000032:analysis* / Q000378:metabolism; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D006046:Gold / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D010455:Peptides; D006046:Gold; D053148:Caspase 3; D016650:Fluorescein-5-isothiocyanate