title: Variants in HAVCR1 gene region contribute to hepatitis C persistence in African Americans.
abstract: To confirm previously identified polymorphisms in HAVCR1 that were associated with persistent hepatitis C virus (HCV) infection in individuals of African and of European descent, we studied 165 subjects of African descent and 635 subjects of European descent. Because the association was only confirmed in subjects of African descent (rs6880859; odds ratio, 2.42; P = .01), we then used 379 subjects of African descent (142 with spontaneous HCV clearance) to fine-map HAVCR1. rs111511318 was strongly associated with HCV persistence after adjusting for IL28B and HLA (adjusted P = 8.8 × 10(-4)), as was one 81-kb haplotype (adjusted P = .0006). The HAVCR1 genomic region is an independent genetic determinant of HCV persistence in individuals of African descent.
authors: Bloomberg School of Public Health, Johns Hopkins University, Baltimore.
authors: Genevieve
authors: G
authors: Wojcik
authors: Rachel
authors: R
authors: Latanich
authors: Tim
authors: T
authors: Mosbruger
authors: Jacquie
authors: J
authors: Astemborski
authors: Gregory D
authors: GD
authors: Kirk
authors: Shruti H
authors: SH
authors: Mehta
authors: James J
authors: JJ
authors: Goedert
authors: Arthur Y
authors: AY
authors: Kim
authors: Eric C
authors: EC
authors: Seaberg
authors: Michael
authors: M
authors: Busch
authors: David L
authors: DL
authors: Thomas
authors: Priya
authors: P
authors: Duggal
authors: Chloe L
authors: CL
authors: Thio
mesh_terms: D001741:Black or African American; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D000072596:Hepatitis A Virus Cellular Receptor 1; D019698:Hepatitis C, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011991:Receptors, Virus / Q000235:genetics*
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus
keywords: Tim 1; hepatitis C virus; human genetics
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