title: Opercular myoclonic-anarthric status epilepticus due to glutamic acid decarboxylase antibody-associated encephalitis.
abstract: We report a patient who was diagnosed with opercular myoclonic-anarthric status epilepticus and found to have glutamic acid decarboxylase antibody (GADA)-associated encephalitis, a previously unrecognised aetiology of this condition. The patient was a 23-year-old female admitted for investigation of focal myoclonic status epilepticus in the right side of the face and glossopharyngeal area. Intravenous corticosteroid was administered and improvement was observed in seizure activity and overall general health. A video sequence of opercular myoclonia is included. Due to the presence of inflammatory elements based on brain MRI and CSF studies, a decision to investigate autoimmune encephalitis was undertaken. Anti-GAD65 radioimmunoassay was markedly positive. This case study highlights the need for awareness of the clinical presentation of GADA-associated encephalitis. [Published with video sequences].
authors: Centro de Cirurgia de Epilepsia, Hospital das Clínicas de Ribeirão Preto, Ribeirão Preto/SP, Brazil.
authors: Bruno Zanotelli
authors: BZ
authors: Monnerat
authors: Tonicarlo Rodrigues
authors: TR
authors: Velasco
authors: Frederico Nakane
authors: FN
authors: Nakano
authors: Alexandre Veriano
authors: AV
authors: Júnior
authors: Ana Paula Pinheiro
authors: AP
authors: Martins
authors: Américo Ceiki
authors: AC
authors: Sakamoto
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000134:cerebrospinal fluid / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications* / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications* / Q000276:immunology*; D004831:Epilepsies, Myoclonic / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D013226:Status Epilepticus / Q000209:etiology* / Q000503:physiopathology; D014741:Video Recording; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D001323:Autoantibodies; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2; D008775:Methylprednisolone