title: Four tumor necrosis factor alpha genes polymorphisms and periodontitis risk in a Chinese population.
abstract: BACKGROUND
  Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T, -308G/A and -238G/A) with susceptibility to AgP and CP in a Chinese population.
  
  
  METHODS
  A hospital-based case-control study was conducted in in patients with CP (n = 180), AgP (n = 180) and healthy controls (n = 180). Gene promoter polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Genotype and allele frequencies were analyzed using the chi-square test and logistic regression analysis.
  
  
  RESULTS
  TNF-alpha -1031CC genotype was significantly higher [odds ratio (OR) = 2.36, 95% confidence interval (CI) = 1.03, 5.43; P = 0.04] in patients with CP compared with healthy controls. TNF-alpha -308AA genotype was significantly higher (OR = 2.71, 95% CI = 1.09, 6.73; P = 0.03) in patients with AgP compared with healthy controls. No association was found of TNF-alpha -857C/T and -238G/A polymorphisms with susceptibility to AgP or CP.
  
  
  CONCLUSIONS
  Our data demonstrated that TNF-alpha -1031CC genotype was a risk factor for CP, and that TNF-alpha -308AA genotype was a risk factor for AgP. But there is a lack of association of TNF-alpha -857C/T and -238G/A polymorphisms with susceptibility to AgP or CP in a Chinese population.
authors: Department of Geriatric Dentistry, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Wenwei
authors: W
authors: Yang
authors: Yue
authors: Y
authors: Jia
authors: Hongkun
authors: H
authors: Wu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha