title: Control of relapsed germ cell tumor and SLE nephritis by high-dose chemotherapy and autologous hematopoietic cell transplantation.
abstract: High-dose chemotherapy and hematopoietic stem cell support remains a curative treatment option for relapsed or nonresponsive germ cell tumors, and has been applied experimentally to control severe autoimmune diseases. In the present study, we report on a patient with systemic lupus erythematosus nephritis who developed a nonseminomatous germ cell tumor that relapsed after standard chemotherapy and surgery. The patient received high-dose chemotherapy supported by autologous hematopoietic cell transplantation based on its indication for relapsed germ cell tumors. Prolonged control of his relapsed germ cell tumor and systemic lupus erythematosus was attained with high-dose chemotherapy and hematopoietic stem cell support. An extensive literature review is provided alongside a detailed discussion of the aforementioned case.
authors: Department of Medicine, 2nd Division of Medical Oncology & Hematopoietic Cell Transplantation Program, Metaxa Cancer Hospital, 51 Botassi Street, Piraeus, Greece. ckosmas1@hotmail.com
authors: Christos
authors: C
authors: Kosmas
authors: Theodora
authors: T
authors: Papachrysanthou
authors: Theodoros
authors: T
authors: Daladimos
authors: Aggelos
authors: A
authors: Athanasopoulos
authors: Nicolas
authors: N
authors: Tsavaris
authors: Panayiotis G
authors: PG
authors: Vlachoyiannopoulos
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D008181:Lupus Nephritis / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D009373:Neoplasms, Germ Cell and Embryonal / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D011379:Prognosis; D016879:Salvage Therapy; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin