title: Reproductive endocrinology: maternal cholestasis and offspring metabolic abnormalities.
abstract: Papacleovoulou and colleagues demonstrate that maternal cholestasis during pregnancy is associated with offspring adiposity and metabolic abnormalities, both in humans and in mice. This study reinforces the overwhelming evidence of the critical role of the in utero environment as a major determinant of adult health and disease.
authors: David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA.
authors: Mina
authors: M
authors: Desai
authors: Michael G
authors: MG
authors: Ross
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D002779:Cholestasis / Q000097:blood / Q000139:chemically induced / Q000150:complications*; D002784:Cholesterol / Q000097:blood; D019826:Cholic Acid / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000097:blood / Q000209:etiology; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D001647:Bile Acids and Salts; D002784:Cholesterol; D019826:Cholic Acid
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