title: Automated quantification of pulmonary perfused blood volume by dual-energy CTPA in chronic thromboembolic pulmonary hypertension.
abstract: OBJECTIVE
  The aim of the study was to determine whether automated quantification of pulmonary perfused blood volume (PBV) in dual-energy computed tomography pulmonary angiography (DE-CTPA) can be used to assess the severity of chronic thromboembolic pulmonary hypertension (CTEPH).
  
  
  METHODS
  Automated quantification of PBV was performed in 25 consecutive CTEPH patients undergoing DE-CTPA. PBV values were correlated with cardiac index and pulmonary vascular resistance quantified by right heart catheterization and walking distance in the 6-minute walk test using Pearson's correlation coefficient and multivariate linear regression analysis to control for age and gender.
  
  
  RESULTS
  DE-CTPA derived PBV values inversely correlated with systolic (r = -0.64, p = 0.001) and mean (r = -0.57, p = 0.004) pulmonary arterial pressure. There was a trend for PBV values to inversely correlate with pulmonary vascular resistance (r = -0.20, p = 0.35). No significant correlation was found between PBV values and cardiac index or 6-minute walking distance. These correlations were confirmed to be independent of age and gender on multivariate linear regression analysis.
  
  
  CONCLUSIONS
  DE-CTPA can be used for an automated quantification of pulmonary PBV in chronic thromboembolic pulmonary hypertension. PBV values correlate inversely with systolic and mean pulmonary arterial pressure and can thus be used to estimate the severity of pulmonary hypertension in these patients. Citation Format: • Meinel FG, Graef A, Thierfelder KM et al. Automated Quantification of Pulmonary Perfused Blood Volume by Dual-Energy CTPA in Chronic Thromboembolic Pulmonary Hypertension. Fortschr Röntgenstr 2014; 186: 151 - 156.
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: F G
authors: FG
authors: Meinel
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: A
authors: A
authors: Graef
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: K M
authors: KM
authors: Thierfelder
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: M
authors: M
authors: Armbruster
authors: Department of Internal Medicine V, Ludwig-Maximilians-University Hospital Munich.
authors: C
authors: C
authors: Schild
authors: Department of Internal Medicine V, Ludwig-Maximilians-University Hospital Munich.
authors: C
authors: C
authors: Neurohr
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: M F
authors: MF
authors: Reiser
authors: Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich.
authors: T R C
authors: TR
authors: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000792:Angiography; D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*