title: Does effective depression treatment alone reduce secondary HIV transmission risk? Equivocal findings from a randomized controlled trial.
abstract: Depressed mood has been associated with HIV transmission risk behavior. To determine whether effective depression treatment could reduce the frequency of sexual risk behavior, we analyzed secondary outcome data from a 36-week, two-arm, parallel-design, randomized controlled trial, in which homeless and marginally housed, HIV-infected persons with comorbid depressive disorders were randomized to receive either: (a) directly observed treatment with the antidepressant medication fluoxetine, or (b) referral to a local public mental health clinic. Self-reported sexual risk outcomes, which were measured at 3, 6, and 9 months, included: total number of sexual partners, unprotected sexual intercourse, unprotected sexual intercourse with an HIV-uninfected partner or a partner of unknown serostatus, and transactional sex. Estimates from generalized estimating equations regression models did not suggest consistent reductions in sexual risk behaviors resulting from treatment. Mental health interventions may need to combine depression treatment with specific skills training in order to achieve durable impacts on HIV prevention outcomes.
authors: Chester M. Pierce, MD Division of Global Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA, actsai@partners.org.
authors: Alexander C
authors: AC
authors: Tsai
authors: Matthew J
authors: MJ
authors: Mimiaga
authors: James W
authors: JW
authors: Dilley
authors: Gwendolyn P
authors: GP
authors: Hammer
authors: Dan H
authors: DH
authors: Karasic
authors: Edwin D
authors: ED
authors: Charlebois
authors: James L
authors: JL
authors: Sorensen
authors: Steven A
authors: SA
authors: Safren
authors: David R
authors: DR
authors: Bangsberg
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006703:Ill-Housed Persons / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D018570:Risk Assessment; D012309:Risk-Taking; D012495:San Francisco / Q000453:epidemiology; D012725:Sexual Behavior / Q000706:statistics & numerical data; D012747:Sexual Partners
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine
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