title: Associations between DGAT1, FABP4, LEP, RORC, and SCD1 gene polymorphisms and fat deposition in Spanish commercial beef.
abstract: The objective of the present study was to assess the frequency distribution of markers in the diacylglycerol acyltransferase (DGAT1), fatty acid binding protein 4 (FABP4), leptin (LEP), retinoic acid receptor-related orphan receptor C (RORC), and stearoyl-CoA desaturase (SCD1) genes in a Spanish commercial crossbred population (n = 286) produced in southwest Spain. We have also evaluated the association of these 5 major SNP with backfat thickness (BFT) and intramuscular fat (IMF) to use them routinely in the industry (if the associations are confirmed) due to their ease of use. The KK genotype of the DGAT1 gene was associated (P = 0.046) with the greatest BFT value. Bulls presenting the GG genotype for SNP in the FABP4 gene showed greater values for the percentage of IMF (P = 0.030), which means an increase of 0.155% IMF per copy of the G allele of this marker (P = 0.009). A significant association was found between the RORC: g.3290T > G marker and the percentage of IMF. The GG genotype of the RORC: g.3290T > G marker showed the lowest IMF percentage (P = 0.025). The specific associations found in this study not only provide information about the involvement of these genes in the fat deposition at different levels in the southwestern Spain cattle population, but can also serve as a tool to improve certain meat quality attributes through Marker Assisted Selection. However, sensory studies are needed to explore further the usefulness of these genes in meat quality and the impact on the actual palatability of the beef.
authors: MERAGEM Research Group, University of Cordoba, Campus de Rabanales, E-14071 Cordoba, Spain.
authors: C
authors: C
authors: Avilés
authors: O
authors: O
authors: Polvillo
authors: F
authors: F
authors: Peña
authors: M
authors: M
authors: Juárez
authors: A L
authors: AL
authors: Martínez
authors: A
authors: A
authors: Molina
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002417:Cattle / Q000235:genetics* / Q000502:physiology*; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005838:Genotype; D020738:Leptin / Q000235:genetics / Q000378:metabolism; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000502:physiology*; D013030:Spain; D013230:Stearoyl-CoA Desaturase / Q000235:genetics / Q000378:metabolism
chemical_list: D050556:Fatty Acid-Binding Proteins; D020738:Leptin; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D013230:Stearoyl-CoA Desaturase; D051048:Diacylglycerol O-Acyltransferase