title: Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.
authors: Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, Massachusetts, USA. jcflorez@partners.org
authors: Jose C
authors: JC
authors: Florez
mesh_terms: D002918:Chymotrypsin / Q000235:genetics*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D005260:Female; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D054795:Incretins / Q000378:metabolism*; D008297:Male; D018027:Receptors, Glucagon / Q000378:metabolism*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D007004:Hypoglycemic Agents; D054795:Incretins; D018027:Receptors, Glucagon; D002918:Chymotrypsin; C117609:chymotrypsin B
references: Nat Genet. 2012 Sep;44(9):991-1005
references: 22885924
references: Nat Genet. 2009 Jun;41(6):703-7
references: 19430480
references: N Engl J Med. 2010 Dec 9;363(24):2339-50
references: 21142536
references: Science. 2008 Nov 7;322(5903):881-8
references: 18988837
references: J Am Chem Soc. 2010 Mar 24;132(11):3819-30
references: 20178363
references: J Clin Endocrinol Metab. 2013 Apr;98(4):E801-6
references: 23457408
references: Diabetes. 2013 Sep;62(9):3275-81
references: 23674605
references: PLoS Genet. 2012;8(8):e1002793
references: 22876189
references: Nat Rev Genet. 2008 May;9(5):356-69
references: 18398418
references: Ann N Y Acad Sci. 2010 Nov;1212:59-77
references: 21091714
references: Nat Genet. 2012 Sep;44(9):981-90
references: 22885922
references: N Engl J Med. 2010 Jul 8;363(2):166-76
references: 20647212
references: N Engl J Med. 2009 Apr 23;360(17):1699-701
references: 19369661