title: Therapeutic effects of Shenfu Injection on post-cardiac arrest syndrome.
abstract: Survival rates after cardiac arrest have not changed substantially over the past 5 decades. Postcardiac arrest (CA) syndrome (PCAS) is the primary reason for the high mortality rate after successful restoration of spontaneous circulation (ROSC). Intravenous administration of Shenfu Injection (, SFI) may attenuate post-CA myocardial dysfunction and cerebral injury, inhibit systemic ischemia/reperfusion responses, and treat underlying diseases. In this article, we reviewed the therapeutic effects of SFI in PCAS. SFI might be useful in the treatment of PCAS, incorporating the multi-link and multi-target advantages of Chinese medicine into PCAS management. Further experimental and clinical research to verify the therapeutic effects of SFI in PCAS is required.
authors: Emergency Department of Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors: Zhi-jun
authors: ZJ
authors: Guo
authors: Chun-sheng
authors: CS
authors: Li
mesh_terms: D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use*; D006323:Heart Arrest / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007267:Injections; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; C492793:Shen-Fu
references: Continuum (Minneap Minn). 2011 Oct;17(5 Neurologic Consultation in the Hospital):1094-118
references: 22809984
references: J Thorac Cardiovasc Surg. 2003 Jun;125(6):1268-75
references: 12830043
references: Shock. 2012 Aug;38(3):301-6
references: 22683733
references: N Engl J Med. 2001 Nov 15;345(20):1473-82
references: 11794197
references: J Am Coll Cardiol. 1996 Jul;28(1):232-40
references: 8752819
references: N Engl J Med. 1984 May 3;310(18):1137-40
references: 6709008
references: Resuscitation. 2011 Sep;82(9):1138-43
references: 21745533
references: Circulation. 1984 Apr;69(4):822-35
references: 6697465
references: Circulation. 2008 Dec 2;118(23):2452-83
references: 18948368
references: Resuscitation. 2013 Feb;84(2):233-8
references: 22771871
references: Crit Care Med. 2006 Dec;34(12 Suppl):S458-65
references: 17114978
references: Shock. 2009 Aug;32(2):210-6
references: 19060788
references: Ann Thorac Surg. 2004 Sep;78(3):948-55
references: 15337026
references: Circulation. 1988 Aug;78(2):382-9
references: 3396175
references: Crit Care Med. 2008 Nov;36(11 Suppl):S418-21
references: 20449904
references: N Engl J Med. 2002 Feb 21;346(8):546
references: 11856792
references: Shock. 2011 May;35(5):530-6
references: 21263380
references: J Endotoxin Res. 2003;9(3):192-8
references: 12831462
references: Am J Chin Med. 2004;32(2):209-20
references: 15315259
references: Chin J Integr Med. 2012 Mar;18(3):164-5
references: 22466938
references: Chin J Integr Med. 2012 Jul;18(7):548-55
references: 22772919
references: Resuscitation. 2012 May;83(5):640-4
references: 22115934
references: JAMA. 2008 Sep 24;300(12):1423-31
references: 18812533