title: Chromatin targeting drugs in cancer and immunity.
abstract: Recent advances in the enzymology of transcription and chromatin regulation have led to the discovery of proteins that play a prominent role in cell differentiation and the maintenance of specialized cell functions. Knowledge about post-synthetic DNA and histone modifications as well as information about the rules that guide the formation of multimolecular chromatin-bound complexes have helped to delineate gene-regulating pathways and describe how these pathways are altered in various pathological conditions. The present review focuses on the emerging area of therapeutic interference with chromatin function for the purpose of cancer treatment and immunomodulation.
authors: Epinova DPU, Immuno-Inflammation Therapy Area, Medicines Research Centre, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
authors: Rab
authors: R
authors: Prinjha
authors: Alexander
authors: A
authors: Tarakhovsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002843:Chromatin / Q000187:drug effects*; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000235:genetics; D056747:Immunomodulation / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy*; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D002843:Chromatin; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2
keywords: cancer; chromatin; immunity
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