title: [Neutropenia and sepsis].
abstract: The clinical management of neutropenic infections represents a great diagnostic and therapeutic challenge. Established sepsis criteria only partially reflect the neutropenic setting. Diagnostic procedures are frequently impaired by thrombocytopenia and progressive respiratory insufficiency. Increased tendency to bleed, engraftment, and fulminant progression represent major therapeutic challenges. Thus, crucial for the diagnosis and therapy of neutropenic sepsis are clear and well-communicated algorithms, rapid action, and close collaboration between oncologists and intensivists.
authors: Internistische Intensivstation, Klinik I für Innere Medizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937 Köln, Deutschland. matthias.kochanek@uk-koeln.de
authors: M
authors: M
authors: Kochanek
authors: B
authors: B
authors: Böll
authors: M
authors: M
authors: Hallek
authors: M
authors: M
authors: von Bergwelt-Baildon
mesh_terms: D003422:Critical Care / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D009503:Neutropenia / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D018805:Sepsis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
references: Crit Care Med. 2012 Jan;40(1):43-9
references: 21926615
references: Crit Care. 2012 Jul 24;16(4):R133
references: 22827955
references: Crit Care Clin. 2010 Jan;26(1):59-91
references: 19944276
references: Intensive Care Med. 2008 May;34(5):847-55
references: 18214437
references: Support Care Cancer. 2007 Dec;15(12):1393-8
references: 17516092
references: Crit Care Med. 2013 Feb;41(2):580-637
references: 23353941
references: Medicine (Baltimore). 2004 Nov;83(6):360-370
references: 15525848
references: Cochrane Database Syst Rev. 2011 Apr 13;(4):CD004388
references: 21491390
references: Cancer. 2006 May 15;106(10):2258-66
references: 16575919
references: Anaesthesist. 2006 Aug;55(8):835-45
references: 16810538
references: Intensive Care Med. 1998 Dec;24(12):1283-8
references: 9885881
references: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007107
references: 19160320
references: Infect Control Hosp Epidemiol. 2013 Jan;34(1):89-92
references: 23221198
references: Crit Care Med. 2009 Apr;37(4):1185-96
references: 19242322
references: Cochrane Database Syst Rev. 2008 Jul 16;(3):CD005370
references: 18646125
references: Intensive Care Med. 2006 Jun;32(6):808-22
references: 16715324
references: Clin Infect Dis. 1997 Aug;25(2):247-59
references: 9332520
references: Eur J Cancer. 2009 Sep;45(14):2462-72
references: 19467584
references: Int J Antimicrob Agents. 2008 Nov;32 Suppl 1:S30-3
references: 18778919
references: J Crit Care. 2012 Dec;27(6):739.e1-6
references: 23217573
references: Crit Care Med. 2000 Aug;28(8):2786-92
references: 10966251
references: J Clin Oncol. 2005 Jun 20;23(18):4198-214
references: 15961767
references: BMJ. 2012 Sep 19;345:e5368
references: 22993392
references: Crit Care Med. 2002 Apr;30(4):781-6
references: 11940745
references: Chest. 2006 Jun;129(6):1432-40
references: 16778259
references: Nat Rev Immunol. 2008 Oct;8(10):776-87
references: 18802444
references: Crit Care Med. 2005 Apr;33(4):787-91
references: 15818106
references: J Clin Oncol. 2000 Aug;18(16):3038-51
references: 10944139
references: BMC Cancer. 2010 Nov 08;10:612
references: 21059210
references: Intensive Care Med. 2013 Feb;39(2):165-228
references: 23361625
references: Bone Marrow Transplant. 2005 Aug;36(3):245-50
references: 15937498
references: Mycoses. 2011 Jan;54 Suppl 1:17-26
references: 21126268
references: N Engl J Med. 2001 Feb 15;344(7):481-7
references: 11172189
references: Mol Med. 2010 Jan-Feb;16(1-2):69-82
references: 19949486
references: Clin Infect Dis. 2003 May 1;36(9):1103-10
references: 12715303
references: J Pathol. 2008 Jan;214(2):211-23
references: 18161754