title: Transmission of influenza A/H5N1 viruses in mammals.
abstract: Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.
authors: Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.
authors: M
authors: M
authors: Imai
authors: S
authors: S
authors: Herfst
authors: E M
authors: EM
authors: Sorrell
authors: E J A
authors: EJ
authors: Schrauwen
authors: M
authors: M
authors: Linster
authors: M
authors: M
authors: De Graaf
authors: R A M
authors: RA
authors: Fouchier
authors: Y
authors: Y
authors: Kawaoka
mesh_terms: D000818:Animals; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000502:physiology*; D007251:Influenza, Human / Q000635:transmission* / Q000821:virology*; D008322:Mammals / Q000821:virology*; D009976:Orthomyxoviridae Infections / Q000635:transmission / Q000662:veterinary* / Q000821:virology
keywords: Airborne transmission; Avian H5N1 influenza A virus; Mammalian model
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