title: [Clinicopathological features and prognosis of chronic gastric ulcer with early canceration].
abstract: OBJECTIVE
  To evaluate the clinicopathological features and prognosis of chronic gastric ulcer with early canceration in order to provide useful information for diagnosis and treatment strategies.
  
  
  METHODS
  A retrospective review of clinical data and prognosis from 43 patients of chronic gastric ulcer with early canceration from 2003 to 2010 was conducted. These data were compared with those with primary intra-mucosa gastric cancer (type I and II 275 cases, type III 68 cases).
  
  
  RESULTS
  In 43 cases of chronic gastric ulcer with early canceration, 30 cases (69.8%) were male, 22 cases (51.2%) were younger than 60 years old. Lesions located in the body or antrum of the stomach in 39 cases (90.7%), were less than 2 cm in 26 cases (60.5%), were undifferentiated type in 23 cases (53.5%), and developed lymph node metastasis in 4 cases (9.3%). Lesions of 4 cases of chronic gastric ulcer with early canceration located in the upper third of the stomach, while those of type III primary intra-mucosal gastric cancer all located in the lower two thirds, and the difference was statistically significant (P<0.01). Compared to type III and type I and II primary intra-mucosal gastric cancer, chronic gastric ulcer with early canceration did not differ in clinicopathological characteristics such as histological type, vascular or lymphatic invasion, and lymph nodes metastasis (all P>0.05). The median follow-up time was 57 months (range 16 to 98 months). The 5-year overall survival was 95.3% in chronic gastric ulcer with early canceration group, similar to that of type I, II (97.4%) or type III (94.5%) primary intra-mucosal gastric cancer group (P>0.05).
  
  
  CONCLUSIONS
  The clinicopathological features of chronic gastric ulcer with early canceration are similar to those of primary intra-mucosal gastric cancer. The prognosis is promising for those patients undergoing surgical treatment.
authors: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. sun.yihong@zs-hospital.sh.cn.
authors: Zhen-bin
authors: ZB
authors: Shen
authors: Yi-hong
authors: YH
authors: Sun
authors: Cong
authors: C
authors: Wang
authors: Yong
authors: Y
authors: Fang
authors: Hong-shan
authors: HS
authors: Wang
authors: Xue-fei
authors: XF
authors: Wang
authors: Wei-dong
authors: WD
authors: Chen
authors: Feng-lin
authors: FL
authors: Liu
authors: Kun-tang
authors: KT
authors: Shen
authors: Xin-yu
authors: XY
authors: Qin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*; D013276:Stomach Ulcer / Q000473:pathology*; D055815:Young Adult