title: Eudesmane-type sesquiterpene derivatives from Laggera alata.
abstract: Ten eudesmane-type sesquiterpene derivatives (1-10), including six cuauhtemone derivatives (1-6), one di-norsesquiterpene (3-oxo-di-nor-eudesma-4-en-11-oic acid, 7), and three eudesmane glycosides (alatoside F-H, 8-10) were isolated from the whole plants of Laggera alata together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, acid hydrolysis, and compounds 1 and 7 were studied by single-crystal X-ray diffraction analysis. The absolute configuration of 1 was determined by the application of the modified Mosher's method. All of the isolated eudesmane-type sesquiterpenes were evaluated for their cytotoxic activities on six human cancer cell lines, but all of the compounds were inactive on the tested cell lines in the concentration of 100 μg/mL.
authors: Instituent of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: wang_guocai@hotmail.com.
authors: Guo-Cai
authors: GC
authors: Wang
authors: Guo-Qiang
authors: GQ
authors: Li
authors: Hua-Wei
authors: HW
authors: Geng
authors: Tao
authors: T
authors: Li
authors: Jiao-Jiao
authors: JJ
authors: Xu
authors: Fang
authors: F
authors: Ma
authors: Xia
authors: X
authors: Wu
authors: Wen-Cai
authors: WC
authors: Ye
authors: Yao-Lan
authors: YL
authors: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D045787:Sesquiterpenes, Eudesmane
keywords: Compositae; Eudesmane; Laggera alata; Sesquiterpene