title: Magnetic resonance spectroscopy imaging-directed transrectal ultrasound biopsy increases prostate cancer detection in men with prostate-specific antigen between 4-10 ng/mL and normal digital rectal examination.
abstract: OBJECTIVE
  To evaluate the ability of magnetic resonance spectroscopic imaging to improve prostate cancer detection rate.
  
  
  METHODS
  A retrospective analysis was carried out of 278 men with prostate-specific antigen in the range of 4-10 ng/mL and normal digital rectal examination who underwent transrectal ultrasound-guided prostate biopsy. Outcomes were compared between men who had a standard biopsy versus those who also underwent a prebiopsy magnetic resonance spectroscopic imaging. Men with an abnormal voxel on magnetic resonance spectroscopic imaging had standard transrectal ultrasound biopsies plus biopsies directed to the abnormal voxels.
  
  
  RESULTS
  The study group (n = 140) and control group (n = 138) were similar in baseline parameters, such as mean age, prostate size and mean prostate-specific antigen. The overall cancer detection in the magnetic resonance spectroscopic imaging positive group (24.4%) was more than double that of the control group (10.1%). On comparing the magnetic resonance spectroscopic imaging results with the transrectal ultrasound biopsy findings, magnetic resonance spectroscopic imaging had 95.6% sensitivity, 41.9% specificity, a positive predictive value of 24.4%, a negative predictive value of 98% and an accuracy of 51.4%.
  
  
  CONCLUSIONS
  Magnetic resonance spectroscopic imaging-directed transrectal ultrasound biopsy increases the cancer detection rate compared with standard transrectal ultrasound biopsy in patients with normal digital rectal examination and elevated prostate-specific antigen in the range of 4-10 ng/mL.
authors: Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
authors: Tarun Dilip
authors: TD
authors: Javali
authors: Durgesh Kumar
authors: DK
authors: Dwivedi
authors: Rajeev
authors: R
authors: Kumar
authors: Naranamangalam Raghunathan
authors: NR
authors: Jagannathan
authors: Sanjay
authors: S
authors: Thulkar
authors: Amit Kumar
authors: AK
authors: Dinda
mesh_terms: D051517:Digital Rectal Examination; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen
keywords: magnetic resonance spectroscopic imaging; prostate cancer; transrectal ultrasound-guided biopsy