title: SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells.
abstract: The gut hormone apelin is a major therapeutic focus for several diseases involving inflammation and aberrant cell growth. We investigated whether apelin-36 contained alternative bioactive peptides associated with normal physiology or disease. Amino acid sequence analysis of apelin-36 identified an amidation motif consistent with the formation of a secondary bioactive peptide (SCNH2). SCNH2 is proven to be mitogenic and chemotactic in normal/malignant cells and augments angiogenesis via a PTX-resistant/CT-X-sensitive G protein-coupled receptor (GPCR). Notably, SCNH2 is substantially more potent and sensitive than apelin-13 and vascular endothelial growth factor-A. Endogenous SCNH2 is highly expressed in human tumors and placenta and in mouse embryonic tissues. Our findings demonstrate that SCNH2 is a new apelinergic member with critical pluripotent roles in angiogenesis related diseases and embryogenesis via a non-APJ GPCR.
authors: Angiogenesis Core Facility, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA.
authors: Changge
authors: C
authors: Fang
authors: Ingalill
authors: I
authors: Avis
authors: Caterina
authors: C
authors: Bianco
authors: Natalie
authors: N
authors: Held
authors: Jennifer
authors: J
authors: Morris
authors: Kris
authors: K
authors: Ylaya
authors: Stephen M
authors: SM
authors: Hewitt
authors: Alfred C
authors: AC
authors: Aplin
authors: Roberto F
authors: RF
authors: Nicosia
authors: Laura A
authors: LA
authors: Fung
authors: John D
authors: JD
authors: Lewis
authors: William G
authors: WG
authors: Stetler-Stevenson
authors: David S
authors: DS
authors: Salomon
authors: Frank
authors: F
authors: Cuttitta
keywords: Angiogenesis; Embryogenesis; Migration; Novel Apelinergic Member; SCNH2
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