title: Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline.
abstract: Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.
authors: Department of Biotechnology, GITAM Institute of Technology, GITAM University, Rushikonda, Visakhapatnam - 530 045, INDIA.
authors: Satyanarayana
authors: S
authors: Rentala
authors: Sudhakar
authors: S
authors: Konada
authors: Ramakrishna
authors: R
authors: Chintala
authors: Lakshmi Narasu
authors: LN
authors: Mangamoori
authors: Suryanarayana Murthy
authors: SM
authors: Upadhyayula
authors: Sarva Mangala
authors: SM
authors: Dhurjeti
keywords: Anti-oxidants; Cataract formation; Docking scores; Oxidative stress; gamma-D-crystallin
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