title: All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010.
abstract: BACKGROUND
  Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population.
  
  
  METHODS
  We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender.
  
  
  RESULTS
  Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003).
  
  
  CONCLUSIONS
  Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
authors: Red de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Avda, Monforte de Lemos, Madrid 5 28029, Spain. vhernando@isciii.es.
authors: Victoria
authors: V
authors: Hernando
authors: Belen
authors: B
authors: Alejos
authors: Susana
authors: S
authors: Monge
authors: Juan
authors: J
authors: Berenguer
authors: Lourdes
authors: L
authors: Anta
authors: David
authors: D
authors: Vinuesa
authors: Rosario
authors: R
authors: Palacios
authors: Roberto
authors: R
authors: Muga
authors: Santiago
authors: S
authors: Moreno
authors: Inma
authors: I
authors: Jarrin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000401:mortality*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
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