title: Increased prevalence of major congenital anomalies in births with placental abruption.
abstract: OBJECTIVE
  To examine the association between major congenital anomalies and placental abruption.
  
  
  METHODS
  A register-based retrospective case-control study was carried out from 1987 to 2005. Data on baseline characteristics and birth outcomes were collected from three Finnish national health registers: the Medical Birth Register, National Hospital Discharge Register, and Register of Congenital Malformations. The study population consisted of 4,190 women with singleton birth and placental abruption. Three control women without placental abruption were selected for each case, matched by maternal age, parity, year of birth, and hospital district. The main outcome measure of the study was a major congenital anomaly associated with placental abruption.
  
  
  RESULTS
  In total, 261 (prevalence 623/10,000) births with placental abruption and 415 (prevalence 330/10,000) control births had major congenital anomalies (odds ratio [OR] 1.92, 95% confidence interval [CI] 1.6-2.52). The association was strongest among births with growth restriction and prematurity. Adjusted analysis revealed a significant association with central nervous system anomalies (OR 2.33, 95% CI 1.29-4.23), anomalies of the eyes and ears (OR 1.82, 95% CI 1.08-3.09), cardiovascular anomalies (OR 1.78, 95% CI 1.34-2.37), respiratory anomalies (OR 3.51, 95% CI 1.56-7.90), gastrointestinal anomalies (OR 3.81, 95% CI 2.27-6.41), genitourinary anomalies (OR 2.55, 95% CI 1.73- 3.74), musculoskeletal anomalies (OR 1.67, 95% CI 1.24-2.24), and anomalies of integument (OR 3.29, 95% CI 1.20-8.98) in births complicated by placental abruption.
  
  
  CONCLUSIONS
  Major congenital anomalies are twice as common among neonates born from pregnancies complicated by placental abruption compared with control pregnancies without abruption. This observation applies to several organ systems.
  
  
  METHODS
  II.
authors: Department of Obstetrics and Gynecology and Children's Hospital, University Central Hospital, Helsinki, the THL National Institute for Health and Welfare, Helsinki, and the Science Center, Pirkanmaa Hospital District and School of Health Sciences, University of Tampere, Tampere, Finland; and the Nordic School of Public Health, Gothenburg, Sweden.
authors: Outi
authors: O
authors: Riihimäki
authors: Marjo
authors: M
authors: Metsäranta
authors: Annukka
authors: A
authors: Ritvanen
authors: Mika
authors: M
authors: Gissler
authors: Tiina
authors: T
authors: Luukkaala
authors: Jorma
authors: J
authors: Paavonen
authors: Mika
authors: M
authors: Nuutila
authors: Sture
authors: S
authors: Andersson
authors: Minna
authors: M
authors: Tikkanen
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology*; D000013:Congenital Abnormalities / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D011247:Pregnancy; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies
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