title: Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders.
abstract: We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
authors: Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors: Hiroyuki
authors: H
authors: Hanakawa
authors: Yorihisa
authors: Y
authors: Orita
authors: Yasuharu
authors: Y
authors: Sato
authors: Kinya
authors: K
authors: Uno
authors: Kazunori
authors: K
authors: Nishizaki
authors: Tadashi
authors: T
authors: Yoshino
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D019226:Oral Ulcer / Q000139:chemically induced* / Q000473:pathology; D009960:Oropharynx / Q000473:pathology*
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate