title: Synthesis of optically active β- or γ-alkyl-substituted alcohols through copper-catalyzed asymmetric allylic alkylation with organolithium reagents.
abstract: An efficient one-pot synthesis of optically active β-alkyl-substituted alcohols through a tandem copper-catalyzed asymmetric allylic alkylation (AAA) with organolithium reagents and reductive ozonolysis is presented. Furthermore, hydroboration-oxidation following the Cu-catalyzed AAA leads to the corresponding homochiral γ-alkyl-substituted alcohols.
authors: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors: Sureshbabu
authors: S
authors: Guduguntla
authors: Martín
authors: M
authors: Fañanás-Mastral
authors: Ben L
authors: BL
authors: Feringa
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D055620:Optical Phenomena; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000498:Allyl Compounds; D009942:Organometallic Compounds; D003300:Copper; D008094:Lithium