title: The synthesis of benzo[f]isoindole-1,3-dicarboxylates via an i2-induced 1,3-dipolar cycloaddition reaction.
abstract: An I2-induced 1,3-dipolar cycloaddition reaction has been developed for the synthesis of benzo[f]isoindole-1,3-dicarboxylates from quinones and N-substituted amino esters. The reaction proceeds in good to excellent yields in one step from 3 equiv of amino ester to react with the quinone structure. The utility of this transformation has been highlighted by its use for the construction of benzo[f]isoindole-1,3-dicarboxylates, which have been identified in natural products exhibiting important biological activities.
authors: State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology , Hangzhou 310032, P. R. China.
authors: Yu-Jin
authors: YJ
authors: Li
authors: Huan-Ming
authors: HM
authors: Huang
authors: Hua-Qing
authors: HQ
authors: Dong
authors: Jian-Hong
authors: JH
authors: Jia
authors: Liang
authors: L
authors: Han
authors: Qing
authors: Q
authors: Ye
authors: Jian-Rong
authors: JR
authors: Gao
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D002264:Carboxylic Acids; D054833:Isoindoles; D007455:Iodine