title: The click reaction as an efficient tool for the construction of macrocyclic structures.
abstract: The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures. Given its efficiency it has been widely applied for bioconjugation, polymer and dendrimer synthesis. More recently, this reaction has been utilized for the efficient formation of rigid or shape-persistent, preorganized macrocyclic species. This strategy also allows the installment of useful functionalities, in the form of polar and function-rich 1,2,3-triazole moieties, directly embedded in the macrocyclic structures. This review analyzes the state of the art in this context, and provides some elements of perspective for future applications.
authors: Department of Chemistry, University of Pavia, Viale Taramelli, 10-27100 Pavia, Italy. dario.pasini@unipv.it
authors: Dario
authors: D
authors: Pasini
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D047028:Macrocyclic Compounds
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