title: Multimodal deformable registration of traumatic brain injury MR volumes via the Bhattacharyya distance.
abstract: An important problem of neuroimaging data analysis for traumatic brain injury (TBI) is the task of coregistering MR volumes acquired using distinct sequences in the presence of widely variable pixel movements which are due to the presence and evolution of pathology. We are motivated by this problem to design a numerically stable registration algorithm which handles large deformations. To this end, we propose a new measure of probability distributions based on the Bhattacharyya distance, which is more stable than the widely used mutual information due to better behavior of the square root function than the logarithm at zero. Robustness is illustrated on two TBI patient datasets, each containing 12 MR modalities. We implement our method on graphics processing units (GPU) so as to meet the clinical requirement of time-efficient processing of TBI data. We find that 6 sare required to register a pair of volumes with matrix sizes of 256 × 256 × 60 on the GPU. In addition to exceptional time efficiency via its GPU implementation, this methodology provides a clinically informative method for the mapping and evaluation of anatomical changes in TBI.
authors: School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. louyifei@gmail.com
authors: Yifei
authors: Y
authors: Lou
authors: Andrei
authors: A
authors: Irimia
authors: Patricio A
authors: PA
authors: Vela
authors: Micah C
authors: MC
authors: Chambers
authors: John D
authors: JD
authors: Van Horn
authors: Paul M
authors: PM
authors: Vespa
authors: Allen R
authors: AR
authors: Tannenbaum
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D016008:Statistical Distributions; D014783:Viscosity
references: Med Image Anal. 2008 Feb;12(1):42-54
references: 17683976
references: Magn Reson Med. 1990 Jul;15(1):152-7
references: 2374495
references: IEEE Trans Med Imaging. 2004 Dec;23(12):1508-16
references: 15575408
references: Proc SPIE Int Soc Opt Eng. 2012 Mar 23;8314:831402
references: 24465115
references: Med Image Anal. 1996 Mar;1(1):35-51
references: 9873920
references: Prehosp Emerg Care. 2004 Jul-Sep;8(3):254-61
references: 15295724
references: IEEE Trans Med Imaging. 1997 Apr;16(2):187-98
references: 9101328
references: Med Image Comput Comput Assist Interv. 2011;14(Pt 2):639-46
references: 21995083
references: Front Neurol. 2012 Feb 06;3:10
references: 22363313
references: IEEE Trans Image Process. 2004 Apr;13(4):518-26
references: 15376586
references: Comput Methods Programs Biomed. 2010 Jun;98(3):278-84
references: 19818524
references: Med Image Anal. 2003 Dec;7(4):565-75
references: 14561559
references: Surg Neurol. 1998 Sep;50(3):187-93
references: 9736076
references: Med Phys. 2011 Apr;38(4):2005-18
references: 21626933
references: IEEE Trans Med Imaging. 1999 Aug;18(8):712-21
references: 10534053
references: Neuroimage. 2009 Mar;45(1 Suppl):S40-50
references: 19059343
references: IEEE Trans Image Process. 2009 Dec;18(12):2629-39
references: 19674952
references: Med Image Anal. 2002 Jun;6(2):129-42
references: 12045000
references: Med Image Anal. 2008 Feb;12(1):26-41
references: 17659998
references: Med Image Comput Comput Assist Interv. 2011;14(Pt 2):655-62
references: 21995085
references: Neuroimage. 2008 Feb 15;39(4):1654-65
references: 18065243
references: IEEE Trans Image Process. 2007 Nov;16(11):2787-801
references: 17990755
references: J Neurotrauma. 2011 Nov;28(11):2287-306
references: 21787171
references: IEEE Trans Med Imaging. 2003 Aug;22(8):986-1004
references: 12906253
references: Neuroimage. 2006 Aug 1;32(1):79-92
references: 16697666
references: Neuroimage Clin. 2012 Aug 24;1(1):1-17
references: 24179732
references: Comput Biol Med. 2002 Sep;32(5):311-28
references: 12102751
references: AJNR Am J Neuroradiol. 1992 Nov-Dec;13(6):1555-64
references: 1332459
references: J Opt Soc Am A Opt Image Sci Vis. 2004 Jul;21(7):1231-40
references: 15260255
references: IEEE Trans Med Imaging. 2010 Jan;29(1):19-29
references: 19447700
references: IEEE Trans Image Process. 1996;5(10):1435-47
references: 18290061
references: Proc IEEE Int Symp Biomed Imaging. 2012;:1152-1155
references: 23999192
references: IEEE Trans Med Imaging. 1998 Jun;17(3):463-8
references: 9735909