title: Use of RCM reactions for construction of eight-membered carbocycles and introduction of a hydroxy group at the juncture between five- and eight-membered carbocycles.
abstract: Model studies for total synthesis of YW3699 were carried out in order to introduce a hydroxy group at the ring juncture between 5- and 8-membered carbocycles. The five-membered ring part, hydrazone, and aldehyde with a cyclohexane ring were connected by the Shapiro reaction, followed by conversion to diketones, which were treated with IBX to afford hydroxylated models.
authors: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors: Takahiro
authors: T
authors: Morimitsu
authors: Reiko
authors: R
authors: Mizutani
authors: Katsuyuki
authors: K
authors: Nakashima
authors: Yoshinori
authors: Y
authors: Saito
authors: Motoo
authors: M
authors: Tori
mesh_terms: D003500:Cyclization; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis*
chemical_list: D006844:Hydrocarbons, Cyclic; D013729:Terpenes