title: Hippocampal-cerebellar interaction during spatio-temporal prediction.
abstract: The hippocampus and cerebellum play a role in the process of temporal memory formation. The interaction between these brain regions during the prediction of motor executions nevertheless remains unclear. Using fMRI, we show here that the hippocampus and cerebellum are co-activated during a timing-dependent task that requires accurate prediction timing of finger movements following preceding visual cues, but not during 2 control tasks: a reaction task requiring identical coordination of individual and combined fingers without predicting the motor timing, or an imagery task. In addition, functional connectivity analyses reveal that the hippocampus showed increased functional connectivity with the bilateral hemispheres of the cerebellum. These results suggest that hippocampal-cerebellar interplay occurs during spatio-temporal prediction of movements on the basis of visuomotor integration.
authors: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands.
authors: Yoshiyuki
authors: Y
authors: Onuki
authors: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, 1081 HV, Amsterdam, The Netherlands, Department of Medical Psychology, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands.
authors: Eus J W
authors: EJ
authors: Van Someren
authors: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands, Department of Neuroscience, ErasmusMC, 3000 DR, Rotterdam, The Netherlands.
authors: Chris I
authors: CI
authors: De Zeeuw
authors: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands, Department of Anatomy and Neurosciences, VU University Medical Center, 1007 MC, Amsterdam, The Netherlands.
authors: Ysbrand D
authors: YD
authors: Van der Werf
mesh_terms: D000293:Adolescent; D000328:Adult; D059031:Anticipation, Psychological / Q000502:physiology*; D001931:Brain Mapping; D002531:Cerebellum; D003463:Cues; D005260:Female; D005385:Fingers / Q000502:physiology*; D006624:Hippocampus; D006801:Humans; D007092:Imagination / Q000502:physiology; D007858:Learning / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: cerebellum; cerebro-cerebellar interaction; functional connectivity; hippocampus; spatio-temporal prediction