title: Enhanced efficacy of superparamagnetic iron oxide nanoparticles against antibiotic-resistant biofilms in the presence of metabolites.
abstract: Antibiotic resistance and the lack of new antibacterial agents cause major challenges for the treatment of infections. Here, we describe a simple, broad-spectrum, and low-cost dual-sided approach which uses superparamagnetic iron oxide particles (SPION) in combination with fructose metabolites as an alternative to existing antibacterial strategies. This strategy offers further improved efficacy of SPION against persistent gram-positive and gram-negative bacteria infections by manipulating the biofilm metabolic microenvironment and outperforms vancomycin (the antibiotic of last resort), creating a new nanotechnology-driven approach.
authors: Center for Biomedical Engineering, School of Engineering, Brown University, RI, USA, 02912.
authors: Naside Gozde
authors: NG
authors: Durmus
authors: Erik N
authors: EN
authors: Taylor
authors: Kim M
authors: KM
authors: Kummer
authors: Thomas J
authors: TJ
authors: Webster
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D005290:Ferric Compounds / Q000737:chemistry*; D005632:Fructose / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000502:physiology*; D014640:Vancomycin / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D005632:Fructose; D014640:Vancomycin; D015032:Zinc
keywords: antibacterial; antibiotic resistance; biofilm; metabolic simulation; superparamagnetic iron oxide nanoparticles (SPION)