title: Histone deacetylase inhibitors suppress CXCR4-mediated dendritic cell migration by regulation of maturation process.
abstract: Once activated by an infected pathogen, dendritic cells (DC's) migrate toward secondary lymphoid organs, and release inflammatory mediators. Therefore, in some case, mature DC's (mDC's) are considered to be potent inflammatory inducers. In this study we demonstrated that histone acetylation plays an important regulatory role in conserving the migration activity of the DC's. We showed that histone deacetylase (HDAC) inhibition reduces CXC chemokine receptor 4 (CXCR4)-dependent DC's migration. These inhibitory effects were found to be caused by a reduction in the expression of CXCR4, and by the phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and c-Jun N-terminal kinase (JNK). Taken together, histone deacetylase inhibitors (HDACi's) inhibit the phosphorylation of MAP kinases, and this inhibition reduces the expression of CXCR4, and this reduction decreases the chemotactic activity of mDC's.
authors: Department of Biology Education, College of Education, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors: Young Hoon
authors: YH
authors: Kim
authors: Sang-Bae
authors: SB
authors: Han
authors: Jae Kwon
authors: JK
authors: Lee
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D003713:Dendritic Cells / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000276:immunology*; D010766:Phosphorylation; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D056572:Histone Deacetylase Inhibitors; D019718:Receptors, CXCR4; D020928:Mitogen-Activated Protein Kinases
keywords: CXCR4; Cell migration; Dendritic cell; HDAC inhibitor; Inflammation; SDF-1α