title: [Effect of perindopril on the processes of subclinical inflammation in patients with arterial hypertension and type 2 diabetes mellitus].
abstract: We conducted comparative analysis of treatment 52 patients (7 men and 45 women aged 42-64 years, mean age 51.1 years) with I-II degree arterial hypertension (AH) and type 2 diabetes mellitus with the use of angiotensin converting enzyme inhibitor perindopril and with of other drugs. During 6 months effective control of AH was achieved on both treatments. We assessed changes in target organs at the background of 1 year therapy based on the use of perindopril or other antihypertensive preparations. Favorable changes of 24 hour indexes of arterial pressure accord in the group of perindopril treated patients compared with the group of patients treated with other antihypertensive drugs. Therapy with perindopril exerted organoprotective effect which manifested as lowering of microalbuminuria and augmentation of endothelium dependent vasodilation. We demonstrated ability of perindopril to affect proinflammatory status: to suppress factors of subclinical inflammation (interleukin-6 and C-reactive protein) and to elevate level of anti-inflammatory interleukin-10.
authors: T N
authors: TN
authors: Zvereva
authors: E Iu
authors: EIu
authors: Cherniavskaia
authors: O L
authors: OL
authors: Barbarash
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D062186:Arterial Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002097:C-Reactive Protein; D020913:Perindopril