title: Surface functionalization of styrenic block copolymer elastomeric biomaterials with hyaluronic acid via a "grafting to" strategy.
abstract: As a biostable elastomer, the hydrophobicity of styrenic block copolymer (SBC) intensely limits its biomedical applications. In order to overcome such shortcoming, the SBC films were grafted with hyaluronic acid (HA) using a coupling agent. The surface chemistry of the modified films was examined by ATR-FTIR and XPS techniques, and the surface morphology was visually described by AFM. The biological performances of the HA-modified films were evaluated by a series of experiments, such as protein adsorption, platelet adhesion, and in vitro cytocompatibility. It was found that the HA-modified samples showed a low adhesiveness to fibroblast at the initial stage; however, it stimulated the growth of fibroblast. The L929 fibroblast growth presented a strong dependence on the molecular weight (MW) of HA. The samples modified with 17kDa HA exhibited the worst wettability and platelet adhesion, while providing the best results of supporting fibroblast proliferation.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors: Xiaomeng
authors: X
authors: Li
authors: Shifang
authors: S
authors: Luan
authors: Shuaishuai
authors: S
authors: Yuan
authors: Lingjie
authors: L
authors: Song
authors: Jie
authors: J
authors: Zhao
authors: Jiao
authors: J
authors: Ma
authors: Hengchong
authors: H
authors: Shi
authors: Huawei
authors: H
authors: Yang
authors: Jing
authors: J
authors: Jin
authors: Jinghua
authors: J
authors: Yin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D020724:Elastomers / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D008970:Molecular Weight; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness; D011137:Polystyrenes / Q000737:chemistry*; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D017155:Wettability
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D011137:Polystyrenes; D006820:Hyaluronic Acid
keywords: Cytocompatibility; Hemocompatibility; Hyaluronic acid (HA); Styrenic block copolymer (SBC); Surface functionalization