title: Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration.
abstract: Studies in the central nervous system (CNS) and retina have revealed the significance of docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22:6), fatty acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio- and synaptogenesis in memory and vision, and it is the precursor for docosanoids and neuroprotectin D1 (NPD1; 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers three targets in ophthalmology for mediator lipidomics, a subgroup within the field of metabolomics: inflammation, neuroprotection and nerve regeneration. It also discusses the role DHA, NPD1 and other lipid mediators play in these three areas.
authors: Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors: William C
authors: WC
authors: Gordon
authors: Nicolas G
authors: NG
authors: Bazan
mesh_terms: D000818:Animals; D003316:Corneal Diseases / Q000276:immunology* / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000276:immunology*; D009416:Nerve Regeneration / Q000276:immunology*; D012164:Retinal Diseases / Q000276:immunology* / Q000378:metabolism
chemical_list: D004281:Docosahexaenoic Acids