title: Hormone replacement therapy in females can decrease the risk of lung cancer: a meta-analysis.
abstract: The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI  = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI<25 kg/m² (OR = 0.65, P = 0.000), and never smokers patients (OR = 0.86, P = 0.042). However, HRT use in patients with artificial menopause could increase the lung cancer risk, OR = 1.51(P = 0.001). The result of Egger's test did not show any evidence of publican bias (P = 0.069). In conclusion, our meta-analysis on HRT and lung cancer risk suggests that HRT use is correlated with decreased lung cancer risk in female, especially in female with BMI<25 kg/m² and never smokers.
authors: Jinling Hospital, Department of Respiratory Medicine, Nanjing University, School of Medicine, Nanjing, China.
authors: Yanwen
authors: Y
authors: Yao
authors: Xiaoling
authors: X
authors: Gu
authors: Juehua
authors: J
authors: Zhu
authors: Dongmei
authors: D
authors: Yuan
authors: Yong
authors: Y
authors: Song
mesh_terms: D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D012306:Risk
references: Contraception. 2006 Apr;73(4):331-5
references: 16531161
references: J Clin Oncol. 2006 Jan 1;24(1):59-63
references: 16314616
references: Maturitas. 2004 Aug 20;48(4):333-46
references: 15283925
references: JAMA. 2002 Jul 17;288(3):321-33
references: 12117397
references: Am J Epidemiol. 1996 Sep 15;144(6):610-21
references: 8797521
references: Climacteric. 2009;12 Suppl 1:71-5
references: 19811246
references: JAMA. 2002 Jul 3;288(1):58-66
references: 12090863
references: Cancer Causes Control. 2012 Mar;23(3):487-96
references: 22367699
references: Chest. 2005 Jul;128(1):370-81
references: 16002959
references: Cancer. 2007 Oct 15;110(8):1768-75
references: 17879370
references: Int J Cancer. 1989 Nov 15;44(5):833-9
references: 2583865
references: Obstet Gynecol. 2003 Sep;102(3):565-70
references: 12962944
references: Cancer Res. 2005 Jul 15;65(14):6450-8
references: 16024650
references: Int J Cancer. 2007 May 15;120(10):2214-20
references: 17278095
references: Am J Med Sci. 2002 Oct;324(4):180-4
references: 12385489
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Int J Cancer. 2011 Mar 15;128(6):1404-13
references: 20473922
references: CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36
references: 21685461
references: Pharmacoepidemiol Drug Saf. 2002 Oct-Nov;11(7):561-7
references: 12462132
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Climacteric. 2012 Jun;15(3):241-9
references: 22612610
references: Epidemiology. 2008 Nov;19(6):785-8; discussion 789-93
references: 18813015
references: Ann Thorac Surg. 2003 Dec;76(6):1789-95
references: 14667585
references: Int J Cancer. 1996 Jul 29;67(3):327-32
references: 8707404
references: J Clin Oncol. 2006 Jan 1;24(1):9-10
references: 16314612
references: J Natl Cancer Inst. 1994 Jun 1;86(11):869-70
references: 8182770
references: Int J Epidemiol. 2003 Apr;32(2):263-71
references: 12714547
references: Int J Cancer. 2005 Nov 20;117(4):662-6
references: 15929081
references: Cancer Causes Control. 2001 Feb;12(2):111-5
references: 11246839
references: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references: 22237781
references: Cancer Res. 1988 Dec 15;48(24 Pt 1):7279-84
references: 3191498
references: Menopause. 2009 Sep-Oct;16(5):1044-8
references: 19387414
references: Lancet. 2009 Apr 11;373(9671):1233-5
references: 19362661
references: Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):560-4
references: 21266521
references: Int J Cancer. 2010 Apr 15;126(8):1997-2001
references: 19795420
references: J Natl Cancer Inst. 2010 Sep 22;102(18):1413-21
references: 20709992
references: Lancet. 2004 May 22;363(9422):1728-31
references: 15158638
references: JAMA. 2008 Nov 26;300(20):2417-9
references: 19033592
references: Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3119-30
references: 21030602
references: Oncology. 2007;73(5-6):305-10
references: 18493157
references: Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):655-60
references: 18349283
references: Am J Epidemiol. 2008 May 1;167(9):1070-80
references: 18343880
references: Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):113-23
references: 14734459
references: Biochem Biophys Res Commun. 2001 Jul 13;285(2):340-7
references: 11444848
references: BMC Med Genet. 2011 Dec 12;12:159
references: 22151803
references: N Engl J Med. 2013 Jan 24;368(4):351-64
references: 23343064
references: Lancet. 2009 Oct 10;374(9697):1243-51
references: 19767090
references: J Clin Oncol. 2010 Mar 20;28(9):1540-6
references: 20159813