title: Sex-specific associations between screen time and lipoprotein subfractions.
abstract: BACKGROUND
  Time spent in sedentary activities (such as watching television) has previously been associated with several risk factors for cardiovascular disease (CVD) such as increased low-density lipoprotein cholesterol (LDL-C). Little is known about associations with lipoprotein subfractions. Using television and computer screen time in hours per day as a measure of sedentary time, we examined the association of screen time with lipoprotein subfractions.
  
  
  METHODS
  Data were used from men and women forming the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study population. Mixed linear models specified lipoprotein measures as the outcome, and screen time as the predictor for fourteen lipoprotein subfraction measures, and included age, smoking status, pedigree, and fat, carbohydrate daily alcohol and energy intake as covariates. Analyses were run separately for men (n = 623) and women (n = 671). A step-down Bonferroni correction was applied to results. The analysis was repeated for significant results (p < .05), additionally controlling for body mass index (BMI) and moderate and vigorous physical activity.
  
  
  RESULTS
  Linear models indicated that screen time was associated with five lipoprotein parameters in women: the concentration of large VLDL particles (p = .01), LDL particle number (p = .01), concentration of small LDL particles (p = .04), the concentration of large HDL particles (p = .04), and HDL diameter (p = .02). All associations remained after controlling for moderate or vigorous physical activity and BMI.
  
  
  CONCLUSIONS
  We show that sedentary time is associated with lipoprotein measures, markers of cardiometabolic disease, independently of physical activity and BMI, in women but not men.
authors: Division of Epidemiology, Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX.
authors: Alexis C
authors: AC
authors: Frazier-Wood
authors: Ingrid B
authors: IB
authors: Borecki
authors: Mary F
authors: MF
authors: Feitosa
authors: Paul N
authors: PN
authors: Hopkins
authors: Caren E
authors: CE
authors: Smith
authors: Donna K
authors: DK
authors: Arnett
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D002784:Cholesterol / Q000097:blood*; D003201:Computers; D015444:Exercise; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012307:Risk Factors; D057185:Sedentary Behavior; D012737:Sex Factors; D013690:Television
chemical_list: D008074:Lipoproteins; D002784:Cholesterol
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