title: [An association of the 825 polymorphism of the g protein 3 subunit with obesity in Kyrgyz population].
abstract: OBJECTIVE
  To study an association of G protein (GP) 3 subunit 825 polymorphism with obesity in native Kyrgyzes.
  
  
  METHODS
  210 persons: 89 patients (female - 35, male - 54) with obesity (body mass index [BMI] more or equal 30 kg/m2) and 121 apparently healthy controls (38 female, 83 male) with normal BMI. Arterial blood pressure, anthropometric measurement and laboratory tests for blood glucose and lipid parameters were performed in all examined persons. DNA was extracted from blood cells and GP3 subunit 825 polymorphism was determined by PCR method.
  
  
  RESULTS
  groups with TT and CT genotypes were combined together because of the rare frequency of TT genotype. Prevalence of + genotypes in group with obesity (0.72) was significantly higher than in controls - 0.52 (odds ratio 2.55, 95% confidence interval [CI] 1.31-4.23; =0.004). Arterial hypertension (45 vs. 31.3%; =0,049) and obesity (51.2 vs. 30%; p<0.01) occurred more often in + genotypes carriers compared with CC homozygotes. A logistic regression model for obesity showed significant effect of 825T allele (relative risk [RR] 2.89, 95% CI 1.25-6.7; =0.013) and irregular intake of vegetables (RR 3.47, 95% CI 1.52-7.94; =0.003) as predictors of obesity development independent of age, sex and physical activity level. In the regression model for arterial hypertension the 825T allele lost its significance after adjustment for obesity.
  
  
  CONCLUSIONS
  GP3 subunit 825 allele in native Kyrgyzes is associated with obesity.
authors: O S
authors: OS
authors: Lunegova
authors: A S
authors: AS
authors: Kerimkulova
authors: A E
authors: AE
authors: Mirrakhimov
authors: S S
authors: SS
authors: Abilova
authors: Iu V
authors: IuV
authors: Zalesskaia
authors: N T
authors: NT
authors: Alibaeva
authors: M B
authors: MB
authors: Sovkhozova
authors: Zh T
authors: ZhT
authors: Isakova
authors: A A
authors: AA
authors: Aldashev
authors: E M
authors: EM
authors: Mirrakhimov
mesh_terms: D000483:Alleles; D015992:Body Mass Index; D004247:DNA / Q000235:genetics*; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007707:Kyrgyzstan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D021122:Protein Subunits / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D004247:DNA; D019204:GTP-Binding Proteins