title: Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen.
abstract: Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.
authors: Department of Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands.
authors: Harshal
authors: H
authors: Zope
authors: Christophe Barnier
authors: CB
authors: Quer
authors: Paul H H
authors: PH
authors: Bomans
authors: Nico A J M
authors: NA
authors: Sommerdijk
authors: Alexander
authors: A
authors: Kros
authors: Wim
authors: W
authors: Jiskoot
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology*; D018899:CpG Islands; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007251:Influenza, Human / Q000517:prevention & control; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000737:chemistry*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control; D010455:Peptides / Q000737:chemistry*; D014612:Vaccines / Q000737:chemistry* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D010455:Peptides; D014612:Vaccines
keywords: adjuvants; nanoparticles; peptide amphiphiles; self-assembly; vaccines