title: Cortical thickness in children receiving intensive therapy for idiopathic apraxia of speech.
abstract: Children with idiopathic apraxia experience difficulties planning the movements necessary for intelligible speech. There is increasing evidence that targeted early interventions, such as Prompts for Restructuring Oral Muscular Phonetic Targets (PROMPT), can be effective in treating these disorders. In this study, we investigate possible cortical thickness correlates of idiopathic apraxia of speech in childhood, and changes associated with participation in an 8-week block of PROMPT therapy. We found that children with idiopathic apraxia (n = 11), aged 3-6 years, had significantly thicker left supramarginal gyri than a group of typically-developing age-matched controls (n = 11), t(20) = 2.84, p ≤ 0.05. Over the course of therapy, the children with apraxia (n = 9) experienced significant thinning of the left posterior superior temporal gyrus (canonical Wernicke's area), t(8) = 2.42, p ≤ 0.05. This is the first study to demonstrate experience-dependent structural plasticity in children receiving therapy for speech sound disorders.
authors: Division of Neurology, Pediatric Neuroimaging Research Consortium (PNRC), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Darren S
authors: DS
authors: Kadis
authors: Debra
authors: D
authors: Goshulak
authors: Aravind
authors: A
authors: Namasivayam
authors: Margit
authors: M
authors: Pukonen
authors: Robert
authors: R
authors: Kroll
authors: Luc F
authors: LF
authors: De Nil
authors: Elizabeth W
authors: EW
authors: Pang
authors: Jason P
authors: JP
authors: Lerch
mesh_terms: D001072:Apraxias / Q000473:pathology* / Q000628:therapy; D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013064:Speech Disorders / Q000473:pathology* / Q000628:therapy
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