title: Antiplatelet treatment in the secondary prevention of coronary and cerebrovascular disease: is there any place for novel agents?
abstract: Ischemic heart disease and cerebrovascular disease remain major health problems with associated mortality and quality-of-life consequences. Antiplatelet agents, including thienopyridines and the new P2Y12 inhibitors, have been shown to improve survival in the secondary prevention setting. We review the available evidence on the effectiveness and safety of previous established as well as novel antithrombotic agents in the secondary prevention of cardiovascular disease with a special focus on cerebrovascular disease.
authors: Department of Cardiology, University of Ioannina, Medical School, Ioannina, Greece dr.ntalas@gmail.com.
authors: Ioannis V
authors: IV
authors: Ntalas
authors: Department of Internal Medicine, University of Ioannina, Medical School, Ioannina, Greece.
authors: Haralampos J
authors: HJ
authors: Milionis
authors: Department of Internal Medicine, University of Ioannina, Medical School, Ioannina, Greece.
authors: Anastazia A
authors: AA
authors: Kei
authors: Department of Cardiology, University of Ioannina, Medical School, Ioannina, Greece.
authors: Kallirroi I
authors: KI
authors: Kalantzi
authors: Department of Cardiology, University of Ioannina, Medical School, Ioannina, Greece.
authors: John A
authors: JA
authors: Goudevenos
mesh_terms: D004359:Drug Therapy, Combination; D065427:Factor Xa Inhibitors / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D009203:Myocardial Infarction / Q000517:prevention & control*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D055502:Secondary Prevention; D020521:Stroke / Q000517:prevention & control*
chemical_list: D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors
keywords: antiplatelet agents; aspirin; clopidogrel; prasugrel; stroke; ticagrelor