title: Relationship between plasma mid-regional pro-adrenomedullin level and resistance to antihypertensive therapy in stable kidney transplant recipients.
abstract: We investigated the relationship between plasma mid-regional pro-adrenomedullin (MR-proADM)-like immunoreactive substance (IS) level and clinical characteristics associated with renal failure or resistance to antihypertensive therapy in stable kidney transplant recipients. Forty-six Japanese kidney transplant recipients who underwent transplantation more than 90 days prior to the study were included. To evaluate resistance to antihypertensive therapy, we calculated the treatment intensity score of the antihypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM-IS levels were measured using an enzyme immunoassay. A significant correlation was observed between plasma MR-proADM-IS level with creatinine clearance or treatment intensity score. Multiple regression analysis identified plasma MR-proADM level and body mass index as significant independent factors associated with treatment intensity score. Plasma MR-proADM level may be a useful biomarker indicating the degree of resistance to antihypertensive therapy.
authors: Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita 879-5593, Japan. Electronic address: y-suzuki@oita-u.ac.jp.
authors: Yosuke
authors: Y
authors: Suzuki
authors: Hiroki
authors: H
authors: Itoh
authors: Fumihiko
authors: F
authors: Katagiri
authors: Fuminori
authors: F
authors: Sato
authors: Kanako
authors: K
authors: Kawasaki
authors: Yukie
authors: Y
authors: Sato
authors: Yuhki
authors: Y
authors: Sato
authors: Hiromitsu
authors: H
authors: Mimata
authors: Masaharu
authors: M
authors: Takeyama
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D014180:Transplantation
chemical_list: D000959:Antihypertensive Agents; D010446:Peptide Fragments; D011498:Protein Precursors; C574167:mid-regional pro-adrenomedullin, human; D053607:Adrenomedullin; D003404:Creatinine