title: Physicochemical evaluation of acid-base disorders after liver transplantation and the contribution from administered fluids.
abstract: OBJECTIVE
  To analyze the mechanism of acid-base disorders in liver transplant recipients and to examine the relationship between these disorders and the fluids administered during surgery.
  
  
  METHODS
  This prospective study in a university-affiliated hospital intensive care unit (ICU) included 52 patients admitted to the ICU from December 2009 to January 2011. We examined the contributions of inorganic ion differences, lactate, unmeasured anions, phosphate, and albumin to metabolic acidosis. In addition to laboratory variables, we collected demographic and clinical data.
  
  
  RESULTS
  Metabolic acidosis (standard base excess ≤ -2.0 mmol/L) was identified in 37 (71.2%) patients during the immediate postoperative period. The inorganic ion difference was the main determinant of acidosis, accounting for -6.17 mEq/L of acidifying effect. The acidemia was attenuated mainly by the alkalinizing effect of albumin reduction, which contributed +6.03 mEq/L. There was an inverse proportional relationship between the quantity of saline solution used during surgery and the inorganic ion difference during the immediate postoperative period.
  
  
  CONCLUSIONS
  Hyperchloremia is the primary contributor to metabolic acidosis in liver transplant recipients. Possibly the use of chloride-rich solutions increases the incidence of this disorder.
authors: Critical Care Department, Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil. marciobt@terra.com.br
authors: M M
authors: MM
authors: Boniatti
authors: E M R
authors: EM
authors: Filho
authors: P R C
authors: PR
authors: Cardoso
authors: S R R
authors: SR
authors: Vieira
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D000328:Adult; D000418:Albumins / Q000009:adverse effects; D000471:Alkalosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001802:Blood Substitutes / Q000009:adverse effects*; D002712:Chlorides / Q000097:blood; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects*; D005780:Gelatin / Q000009:adverse effects; D006785:Hospitals, University; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects; D007362:Intensive Care Units; D007552:Isotonic Solutions / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000077325:Ringer's Lactate; D012965:Sodium Chloride / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000418:Albumins; D015415:Biomarkers; D001802:Blood Substitutes; D002712:Chlorides; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D005780:Gelatin