title: [Fertility preservation in boys: spermatogonial stem cell transplantation and testicular grafting].
abstract: Spermatogonial stem cells (SSC) are the founder cells of spermatogenesis and are responsible for the lifelong production of spermatozoa. The cryopreservation and transplantation of these cells has been proposed as a fertility preservation strategy for young boys at risk for stem cell loss, i.e. patients undergoing chemotherapy for cancer or as a conditioning treatment for bone marrow transplantation. To prevent lifelong sterility in boys, two fertility restoration strategies are being developed: the injection of SSC and the grafting of testicular tissue containing SSC. Depending on the disease of the patient one of these two approaches will be applicable. Grafting has the advantage that SSC can reside within their natural niche, preserving the interactions between germ cells and their supporting cells and may therefore be regarded as the first choice strategy. However, in cases where the risk for malignant contamination of the testicular tissue is real, e.g. leukemia, transplantation of SSC by injection is preferable over grafting.
authors: Biology of the Testis (BITE), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussel, Belgique. ellen.goossens@vub.ac.be
authors: E
authors: E
authors: Goossens
authors: H
authors: H
authors: Tournaye
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology* / Q000637:transplantation*; D000970:Antineoplastic Agents / Q000009:adverse effects; D016026:Bone Marrow Transplantation; D015925:Cryopreservation; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D011627:Puberty; D033581:Stem Cell Transplantation; D013737:Testis / Q000637:transplantation*; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents
keywords: Cellule souche spermatogoniale; Spermatogonial stem cell; Testicular tissue; Tissu testiculaire; Transplantation