title: In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites.
abstract: Upon the screening of 16 antiproliferative compounds against Toxoplasma gondii and Neospora caninum, two hydrolytically stable ruthenium complexes (compounds 16 and 18) exhibited 50% inhibitory concentrations of 18.7 and 41.1 nM (T. gondii) and 6.7 and 11.3 nM (N. caninum). To achieve parasiticidal activity with compound 16, long-term treatment (22 to 27 days at 80 to 160 nM) was required. Transmission electron microscopy demonstrated the rapid impact on and ultrastructural alterations in both parasites. These preliminary findings suggest that the potential of ruthenium-based compounds should thus be further exploited.
authors: Institute of Parasitology, Vetsuisse Faculty, University of Berne, Berne, Switzerland.
authors: Fabienne
authors: F
authors: Barna
authors: Karim
authors: K
authors: Debache
authors: Carsten A
authors: CA
authors: Vock
authors: Tatiana
authors: T
authors: Küster
authors: Andrew
authors: A
authors: Hemphill
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D020128:Inhibitory Concentration 50; D008018:Life Cycle Stages / Q000187:drug effects*; D046529:Microscopy, Electron, Transmission; D018688:Neospora / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D012428:Ruthenium / Q000737:chemistry*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D014709:Vero Cells
chemical_list: D056831:Coordination Complexes; D012428:Ruthenium
references: J Inorg Biochem. 2011 Aug;105(8):1019-29
references: 21666776
references: Antimicrob Agents Chemother. 2008 Jun;52(6):1999-2008
references: 18362190
references: Clin Cancer Res. 2004 Jun 1;10(11):3717-27
references: 15173078
references: Antimicrob Agents Chemother. 1997 Sep;41(9):1849-53
references: 9303372
references: Dalton Trans. 2011 Aug 21;40(31):7817-23
references: 21629963
references: Parasitol Res. 2004 Jun;93(3):178-87
references: 15290254
references: FEBS Lett. 2008 Mar 19;582(6):844-7
references: 18294965
references: Exp Parasitol. 2011 Oct;129(2):95-100
references: 21803039
references: Chem Asian J. 2008 Nov 13;3(11):1890-9
references: 18712745
references: Biochem Biophys Res Commun. 2012 Jan 6;417(1):576-81
references: 22177949
references: J Med Chem. 2008 Nov 13;51(21):6773-81
references: 18834187
references: Anticancer Drugs. 2009 Feb;20(2):97-103
references: 19209025
references: Chem Soc Rev. 2009 Feb;38(2):391-401
references: 19169456
references: J Med Chem. 2011 Jan 13;54(1):3-25
references: 21077686
references: Metallomics. 2009 Nov;1(6):458-70
references: 21305154
references: Antimicrob Agents Chemother. 2009 Oct;53(10):4414-21
references: 19581464
references: J Am Chem Soc. 2007 Jan 10;129(1):46-7
references: 17199281
references: J Parasitol. 1990 Apr;76(2):177-9
references: 2319416
references: J Inorg Biochem. 2004 Jun;98(6):984-90
references: 15149805
references: Parasite. 2011 Aug;18(3):207-14
references: 21894260
references: Free Radic Res. 2009 Oct;43(10):899-912
references: 19670067
references: Parasitology. 2012 Jun;139(7):934-44
references: 22309643
references: Parasitology. 2005 Jan;130(Pt 1):41-8
references: 15700756
references: Mini Rev Med Chem. 2006 Feb;6(2):131-43
references: 16472182
references: Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16
references: 20368397
references: J Mol Struct. 2011 Apr 19;992(1-3):39-47
references: 21552381
references: Parasitology. 2006 Sep;133(Pt 3):261-78
references: 16753081
references: Prev Vet Med. 2006 Dec 18;77(3-4):230-53
references: 16982104
references: J Med Chem. 2012 May 10;55(9):4178-88
references: 22489925
references: ACS Med Chem Lett. 2010 Oct 22;2(1):2-6
references: 24900247
references: Parasitology. 2012 Feb;139(2):208-20
references: 22011664
references: Parasitology. 2006;133 Suppl:S145-68
references: 17274844
references: Curr Top Med Chem. 2012;12(3):219-35
references: 22236158
references: Bioorg Med Chem Lett. 2011 Jan 1;21(1):186-90
references: 21129965
references: J Inorg Biochem. 2006 May;100(5-6):891-904
references: 16603249
references: Nature. 1965 Feb 13;205:698-9
references: 14287410
references: Animals (Basel). 2011 Sep 08;1(3):306-25
references: 26486502
references: Prev Vet Med. 2006 Dec 18;77(3-4):254-83
references: 16962190
references: Curr Top Med Chem. 2011;11(5):521-42
references: 21189131
references: Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005420
references: 16856096
references: Am J Health Syst Pharm. 2011 May 15;68(10):888-92
references: 21546639
references: Beilstein J Org Chem. 2007 Aug 28;3:22
references: 17725838
references: Dalton Trans. 2007 Nov 21;(43):5065-72
references: 17992291
references: Int J Parasitol. 2013 Feb;43(2):133-42
references: 23246675
references: Clin Microbiol Rev. 2007 Apr;20(2):323-67
references: 17428888
references: PLoS Pathog. 2012;8(3):e1002567
references: 22457617
references: Curr Med Chem. 2006;13(9):1085-107
references: 16611086
references: Curr Opin Chem Biol. 2008 Apr;12(2):197-206
references: 18155674
references: Int J Parasitol Drugs Drug Resist. 2012 Apr 02;2:109-20
references: 24533272
references: Am J Vet Res. 1994 Jul;55(7):976-81
references: 7978638
references: Parasitol Res. 2001 Jan;87(1):43-8
references: 11199848
references: Bioorg Med Chem. 2009 Jul 15;17(14):5038-43
references: 19539479
references: Lab Invest. 2011 May;91(5):744-51
references: 21339744
references: Scand J Infect Dis. 2012 Nov;44(11):805-14
references: 22831461
references: J Parasitol. 1989 Dec;75(6):990-2
references: 2614609
references: Eur J Med Chem. 2006 Nov;41(11):1231-9
references: 16828524
references: Expert Opin Drug Discov. 2012 Dec;7(12):1193-206
references: 22998671
references: Br J Pharmacol. 2010 May;160(2):260-9
references: 20105182
references: Gen Diagn Pathol. 1997 Jun;142(5-6):257-70
references: 9228248