title: MRI-visual order-disorder micellar nanostructures for smart cancer theranostics.
abstract: The development of MRI-visual order-disorder structures for cancer nanomedicine explores a pH-triggered mechanism for theragnosis of tumor hallmark functions. Superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with amphiphilic poly(styrene)-b-poly(acrylic acid)-doxorubicin with folic acid (FA) surfacing are employed as a multi-functional approach to specifically target, diagnose, and deliver drugs via a single nanoscopic platform for cancer therapy. The functional aspects of the micellar nanocomposite is investigated in vitro using human breast SkBr3 and colon cancer HCT116 cell lines for the delivery, release, localization, and anticancer activity of the drug. For the first time, concentration-dependent T2 -weighted MRI contrast for a monolayer of clustered cancer cells is shown. The pH tunable order-disorder transition of the core-shell structure induces the relative changes in MRI contrast. The outcomes elucidate the potential of this material for smart cancer theranostics by delivering non-invasive real-time diagnosis, targeted therapy, and monitoring the course and response of the action before, during, and after the treatment regimen.
authors: Biosensors and Bioelectronics Center, Department of Physics, Chemistry and Biology (IFM), Linköping University, 581 83, Linköping, Sweden; Integrative Regenerative Medicine (IGEN) Center, Department of Clinical and Experimental Medicine (IKE), Linköping University, 581 85, Linköping, Sweden.
authors: Hirak K
authors: HK
authors: Patra
authors: Nisar
authors: N
authors: Ul Khaliq
authors: Thobias
authors: T
authors: Romu
authors: Emilia
authors: E
authors: Wiechec
authors: Magnus
authors: M
authors: Borga
authors: Anthony P F
authors: AP
authors: Turner
authors: Ashutosh
authors: A
authors: Tiwari
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D008823:Micelles; D053761:Nanocomposites / Q000737:chemistry*; D050997:Nanomedicine; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D008823:Micelles; D011108:Polymers; D004317:Doxorubicin; D005492:Folic Acid
keywords: custom-fit nanomedicine; personalized therapeutics; smart nanotheranostic; tumor microenvironment