title: An unusual case of hyperlactataemia in a neonate.
abstract: We report a HIV uninfected neonate born to HIV positive mother, who had tachypnoea at birth. On investigations, he was found to have hyperlactataemia. All the secondary causes for elevated lactate were ruled out. Hyperlactataemia was attributed to the perinatal exposure, to maternal antiretroviral (ARV) drugs, mainly nucleoside analogues. Asymptomatic and symptomatic hyperlactataemia is not uncommon in HIV-exposed infants. Neonates with tachypnoea, who are HIV- and ARV-exposed with no obvious cause, should be screened for raised arterial lactate.
authors: Division of Neonatology, Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, India.
authors: Nilay
authors: N
authors: Nirupam
authors: Sushma
authors: S
authors: Nangia
authors: Ajay
authors: A
authors: Kumar
authors: Arvind
authors: A
authors: Saili
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood* / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000635:transmission; D018023:HIV Seronegativity; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000821:virology*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D059246:Tachypnea / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D018894:Reverse Transcriptase Inhibitors
keywords: AIDS; HIV; MTCT; Nucleoside reverse-transcriptase inhibitors; antiretroviral; hyperlactataemia; neonate; paediatric; therapy; transmission