title: The FTO gene rs9939609 polymorphism predicts risk of cardiovascular disease: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Genome-wide association studies have shown that variance in the fat mass- and obesity- associated gene (FTO) is associated with risk of obesity in Europeans and Asians. Since obesity is associated with an increased risk of cardiovascular disease (CVD), several studies have investigated the association between variant in the FTO gene and CVD risk, with inconsistent results. In this study, we performed a meta-analysis to clarify the association of rs9939609 variant (or its proxies [r (2)>0.90]) in the FTO gene with CVD risk.
  
  
  METHODS
  Published literature from PubMed and Embase was retrieved. Pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random- effects model.
  
  
  RESULTS
  A total of 10 studies (comprising 19,153 CVD cases and 103,720 controls) were included in the meta-analysis. The results indicated that the rs9939609 variant was significantly associated with CVD risk (odds ratio = 1.18, 95% confidence interval = 1.07-1.30, p = 0.001 [Z test], I (2) = 80.6%, p<0.001 [heterogeneity]), and there was an insignificant change after adjustment for body mass index (BMI) and other conventional CVD risk factors (odds ratio = 1.16, 95% confidence interval = 1.05-1.27, p = 0.003 [Z test], I (2) = 75.4%, p<0.001 [heterogeneity]).
  
  
  CONCLUSIONS
  The present meta-analysis confirmed the significant association of the rs9939609 variant in the FTO gene with CVD risk, which was independent of BMI and other conventional CVD risk factors.
authors: Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang, China.
authors: Chibo
authors: C
authors: Liu
authors: Sihua
authors: S
authors: Mou
authors: Chunqin
authors: C
authors: Pan
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D002318:Cardiovascular Diseases / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
references: Mol Nutr Food Res. 2011 Jan;55(1):136-49
references: 21207518
references: Science. 2007 May 11;316(5826):889-94
references: 17434869
references: Circ Cardiovasc Genet. 2009 Jun;2(3):260-9
references: 20031594
references: PLoS One. 2012;7(11):e50418
references: 23185617
references: J Physiol Pharmacol. 2012 Jun;63(3):241-8
references: 22791637
references: Int J Obes (Lond). 2008 Sep;32(9):1431-7
references: 18607383
references: Nat Genet. 2009 Jan;41(1):25-34
references: 19079261
references: Eur Heart J. 2008 Oct;29(20):2552-60
references: 18550552
references: Obes Facts. 2011;4(4):290-6
references: 21921652
references: Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):691-8
references: 20400278
references: Am Heart J. 2010 Dec;160(6):1163-9
references: 21146673
references: BMC Med Genet. 2012 Nov 07;13:101
references: 23134754
references: Diabetes. 2011 May;60(5):1637-44
references: 21398525
references: BMC Med. 2011 Jun 08;9:71
references: 21651756
references: PLoS Med. 2012;9(5):e1001212
references: 22563304
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Int Rev Psychiatry. 2012 Jun;24(3):176-88
references: 22724639
references: Biometrics. 1994 Dec;50(4):1088-101
references: 7786990
references: Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):327-32
references: 19910641
references: Diabetes. 2008 May;57(5):1419-26
references: 18346983
references: Int J Obes (Lond). 2008 Dec;32 Suppl 7:S120-6
references: 19136980
references: Cardiovasc J Afr. 2011 Jan-Feb;22(1):25-30
references: 21298202
references: Clin Chim Acta. 2010 Aug 5;411(15-16):1069-72
references: 20362563
references: Diabetologia. 2012 Apr;55(4):981-95
references: 22109280
references: Circ Cardiovasc Genet. 2009 Jun;2(3):255-9
references: 20031593
references: Genet Epidemiol. 2012 Sep;36(6):652-62
references: 22829130