title: Structures and antioxidant and intestinal disaccharidase inhibitory activities of A-type proanthocyanidins from peanut skin.
abstract: Nine compounds including a new A-type proanthocyanidin trimer, epicatechin-(2β→O→7,4β→8)-[catechin-(6→4β)]-epicatechin (8), and a known trimer, epicatechin-(4β→8)-epicatechin-(2β→O→7,4β→8)-catechin (9), being reported for peanut skin for the first time, were isolated and purified. Their structures were determined by spectroscopic methods and by degradation reactions with L-cysteine in acidic conditions. The DPPH radical scavenging activity and the inhibitory activity on maltase and sucrase of the isolated compounds were investigated. All compounds showed strong DPPH scavenging activities (EC₅₀ < 20 μg/mL). Compound 8 showed the strongest inhibitory activity on maltase with an IC₅₀ value of 0.088 mg/mL, while compound 9 exhibited the strongest inhibition on sucrase with an IC₅₀ value of 0.091 mg/mL.
authors: School of Life Sciences, Inner Mongolian University , Huhhot, China.
authors: Huiwen
authors: H
authors: Zhang
authors: Yerigui
authors: Yumei
authors: Y
authors: Yang
authors: Chaomei
authors: C
authors: Ma
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D010367:Arachis / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D007700:Kinetics; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D044945:Proanthocyanidins / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013393:Sucrase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000520:alpha-Glucosidases / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D044945:Proanthocyanidins; D000520:alpha-Glucosidases; D013393:Sucrase