title: Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort.
abstract: Four new ligustilides chuanxiongnolide R1 (1), chuanxiongnolide R2 (2), chuanxiongdiolide R1 (3) and chuanxiongdiolide R2 (4) together with eight known derivatives (5-12) were isolated from the root of Ligusticum chuanxiong Hort. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were confirmed via the circular dichroism (CD) spectrum. The anti-inflammatory assay in LPS-triggered RAW 264.7 macrophages was carried out on the twelve compounds. 1, 3, 5 and 6 showed significant inhibitory effects against LPS-induced NO production.
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: Jian
authors: J
authors: Huang
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: Xiao-Qing
authors: XQ
authors: Lu
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: Cui
authors: C
authors: Zhang
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: Jin
authors: J
authors: Lu
authors: School of Pharmacy, Shihezi University, Shihezi 832002, China.
authors: Guo-Yu
authors: GY
authors: Li
authors: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors: Rui-Chao
authors: RC
authors: Lin
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmacy, Shihezi University, Shihezi 832002, China. Electronic address: tcm_syphu@163.com.
authors: Jin-Hui
authors: JH
authors: Wang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D030004:Ligusticum / Q000737:chemistry*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D008517:Phytotherapy; D018517:Plant Roots
chemical_list: D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; C000588644:chuanxiongdiolide R1; C000588643:chuanxiongnolide R1; D009569:Nitric Oxide; C027820:ligustilide; D015107:4-Butyrolactone
keywords: Anti-inflammatory activity; CD; Ligusticum chuanxiong Hort; Ligustilide