title: Nitric oxide releasing photoresponsive nanohybrids as excellent therapeutic agent for cervical cancer cell lines.
abstract: Gold nanoparticles (GNPs) that can release nitric oxide (NO) on visible-light irradiation were prepared using 2-mercapto-5-nitro benzimidazole (MNBI) as stabilizer. These nanoparticles meet overall prerequisites for biomedical applications like small sizes, water solubility, and stability. It was found that even a very low dosage of MNBI-stabilized GNPs exhibit appreciable tumor cell mortality against cervical cancer cell lines, demonstrating the role of NO in killing cancer cells.
authors: Electrodics and Electrocatalysis Division, CSIR-Central Electrochemical Research Institute , Karaikudi, Tamilnadu 630006, India.
authors: Priya
authors: P
authors: Sudhesh
authors: Kaviyarasan
authors: K
authors: Tamilarasan
authors: Palaniappan
authors: P
authors: Arumugam
authors: Sheela
authors: S
authors: Berchmans
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001562:Benzimidazoles / Q000737:chemistry; D005260:Female; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism*; D012995:Solubility; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014867:Water / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D014867:Water; D009569:Nitric Oxide; D006046:Gold; C031000:benzimidazole