title: Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.
abstract: NK cells are critical in immune responses against pathogens. However, their role in autoimmunity is still controversial. In this study, we demonstrate that neonatal NK cells render newborns more susceptible to neonatal autoimmunity induced by maternal autoantibodies (neonatal autoimmune ovarian disease); thus, neonatal but not adult NK cells are pathogenic after transfer into NK cell-deficient pups. The inhibitory receptors Ly49C/I are expressed in ∼5% of neonatal and ∼50% of adult NK cells. In this study, we show that the presence of Ly49C/I⁺ adult NK cells inhibits neonatal autoimmune ovarian disease induction. Thus, the ontogenetic regulation of Ly49C/I expression determines the propensity to autoantibody-induced autoimmunity. In summary, this study provides definitive evidence of a pathogenic role of NK cells in neonatal autoimmunity and also elucidates a novel mechanism by which neonatal NK cells render newborns more susceptible to autoantibody-induced autoimmunity.
authors: Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
authors: Claudia
authors: C
authors: Rival
authors: Eileen
authors: E
authors: Samy
authors: Yulius
authors: Y
authors: Setiady
authors: Kenneth
authors: K
authors: Tung
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000276:immunology*; D010049:Ovarian Diseases / Q000276:immunology*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies; C527091:Klra3 protein, mouse; D055650:NK Cell Lectin-Like Receptor Subfamily A
references: Immunology. 2010 Dec;131(4):451-8
references: 21039469
references: J Exp Med. 1998 Feb 16;187(4):609-18
references: 9463411
references: J Immunol. 2008 Apr 1;180(7):4366-70
references: 18354156
references: Nat Immunol. 2010 Apr;11(4):321-7
references: 20190757
references: J Immunol. 1995 Sep 1;155(5):2715-20
references: 7650399
references: J Immunol. 2003 May 1;170(9):4656-64
references: 12707344
references: Neurology. 1997 Jan;48(1):50-4
references: 9008493
references: Curr Top Microbiol Immunol. 2011;350:105-25
references: 20680807
references: Trends Immunol. 2009 Dec;30(12):585-91
references: 19846341
references: Diabetes. 2011 Aug;60(8):2102-11
references: 21788582
references: Nat Immunol. 2000 Sep;1(3):245-51
references: 10973283
references: Blood. 2005 Jun 1;105(11):4416-23
references: 15728129
references: J Clin Invest. 2012 Sep;122(9):3260-70
references: 22863621
references: J Leukoc Biol. 2000 Nov;68(5):748-56
references: 11073116
references: Nat Med. 2007 Oct;13(10):1248-52
references: 17891146
references: Nature. 2005 Aug 4;436(7051):709-13
references: 16079848
references: J Immunol. 2004 Jul 15;173(2):1051-8
references: 15240693
references: J Immunol. 1999 Jul 1;163(1):212-6
references: 10384118
references: Nature. 1953 Oct 3;172(4379):603-6
references: 13099277
references: J Exp Med. 2012 Jun 4;209(6):1083-9
references: 22565825
references: Trends Immunol. 2011 Aug;32(8):364-72
references: 21752715
references: Immunity. 1997 Jan;6(1):89-96
references: 9052840
references: Immunol Cell Biol. 2012 Mar;90(3):304-9
references: 22249199
references: Nature. 2009 Jul 9;460(7252):269-73
references: 19494813
references: Cell Mol Life Sci. 2011 Nov;68(21):3505-18
references: 21861182
references: Autoimmunity. 2011 Feb;44(1):3-10
references: 20701455