title: Synthetic approach toward alpha-aminomethyl-gamma-butyrolactones from beta-lactam synthons elaborated by SmI2-mediated reductive coupling reactions.
abstract: A simple and straightforward synthetic approach was developed to access a biologically important class of alpha-aminomethyl-gamma-butyrolactones via a beta-lactam synthon strategy involving successive ring-opening and lactonization processes from alpha-hydroxyethyl-substituted beta-lactams that were elaborated by SmI2-mediated reductive coupling reaction.
authors: Department of Applied Chemistry, Graduate School of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, Shizuoka 432-8561, Japan.
authors: Masaki
authors: M
authors: Takahashi
authors: Takahiro
authors: T
authors: Sudo
authors: Yusuke
authors: Y
authors: Murata
authors: Tetsuya
authors: T
authors: Sengoku
authors: Hidemi
authors: H
authors: Yoda
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D007454:Iodides / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D012493:Samarium / Q000494:pharmacology; D047090:beta-Lactams / Q000737:chemistry*
chemical_list: D007454:Iodides; D007783:Lactones; D047090:beta-Lactams; D012493:Samarium; C409809:samarium diiodide; D015107:4-Butyrolactone