title: Two distinct forms of functional lateralization in the human brain.
abstract: The hemispheric lateralization of certain faculties in the human brain has long been held to be beneficial for functioning. However, quantitative relationships between the degree of lateralization in particular brain regions and the level of functioning have yet to be established. Here we demonstrate that two distinct forms of functional lateralization are present in the left vs. the right cerebral hemisphere, with the left hemisphere showing a preference to interact more exclusively with itself, particularly for cortical regions involved in language and fine motor coordination. In contrast, right-hemisphere cortical regions involved in visuospatial and attentional processing interact in a more integrative fashion with both hemispheres. The degree of lateralization present in these distinct systems selectively predicted behavioral measures of verbal and visuospatial ability, providing direct evidence that lateralization is associated with enhanced cognitive ability.
authors: Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, and Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Stephen J
authors: SJ
authors: Gotts
authors: Hang Joon
authors: HJ
authors: Jo
authors: Gregory L
authors: GL
authors: Wallace
authors: Ziad S
authors: ZS
authors: Saad
authors: Robert W
authors: RW
authors: Cox
authors: Alex
authors: A
authors: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D013028:Space Perception / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: asymmetry; circuit; intelligence; segregation; specialization
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