title: Mechanism study of copper-mediated one-pot reductive amination of aryl halides using trimethylsilyl azide.
abstract: Reaction mechanisms of the copper-mediated amination of aryl halides with trimethylsilyl azide (TMSN3) were analyzed on the basis of the time-course study using reaction monitoring FT-IR, trapping an intermediary aryl azide by the Huisgen reaction, and the analysis of the generated N2 gas during the reaction. This amination would proceed through multiple pathways via aryl radicals and copper(I) azide.
authors: Laboratory of Organic Chemistry, Gifu Pharmaceutical University , 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
authors: Toshihide
authors: T
authors: Maejima
authors: Moriatsu
authors: M
authors: Ueda
authors: Jun
authors: J
authors: Nakano
authors: Yoshinari
authors: Y
authors: Sawama
authors: Yasunari
authors: Y
authors: Monguchi
authors: Hironao
authors: H
authors: Sajiki
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*
chemical_list: D000588:Amines; D001386:Azides; D006846:Hydrocarbons, Halogenated; D012821:Silanes; C438544:azidotrimethylsilane; D003300:Copper