title: Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases.
abstract: OBJECTIVE
  To assess the association between Rosai-Dorfman disease (RDD) and IgG4-related disease (IgG4-RD).
  
  
  METHODS
  We studied the number of IgG4-positive plasma cells and the IgG4/IgG ratio in 32 biopsy specimens (13 nodal, 19 extranodal) from 29 patients with RDD and compared the findings with those in IgG4-RD of the pancreas and reactive lymph nodes. We also assessed the number of FOXP3-positive regulatory T cells (Tregs) since they were reported to be increased in IgG4-RD.
  
  
  RESULTS
  We found that RDD cases had much lower numbers of IgG4-positive plasma cells and lower IgG4/IgG ratios compared with IgG4-RD but were similar to reactive lymph nodes. Furthermore, RDD had lower numbers of FOXP3-positive Tregs than did IgG4-RD. There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases.
  
  
  CONCLUSIONS
  Our study suggests that RDD does not belong in the spectrum of IgG4-RD.
authors: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
authors: Liping
authors: L
authors: Liu
authors: Anamarija M
authors: AM
authors: Perry
authors: Wenfeng
authors: W
authors: Cao
authors: Lynette M
authors: LM
authors: Smith
authors: Eric D
authors: ED
authors: Hsi
authors: Xiuli
authors: X
authors: Liu
authors: Jun Q
authors: JQ
authors: Mo
authors: Snjezana
authors: S
authors: Dotlic
authors: Marina
authors: M
authors: Mosunjac
authors: Geoffrey
authors: G
authors: Talmon
authors: Dennis D
authors: DD
authors: Weisenburger
authors: Kai
authors: K
authors: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015618:Histiocytosis, Sinus / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*; D012598:Sclerosis / Q000276:immunology / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: IgG4-related disease; IgG4/IgG ratio; Regulatory T cells; Rosai-Dorfman disease; Sinus histiocytosis with massive lymphadenopathy