title: Nickel-catalyzed chemo- and stereoselective alkenylative cyclization of 1,6-enynes with alkenyl boronic acids.
abstract: Discover nickel! A nickel-catalyzed alkenylative cyclization of 1,6-enynes and alkenyl boronic acids affording substituted pyrrolidines and dihydrofurans is described (see scheme; cod = 1,5-cyclooctadiene, Ts = p-toluene sulfonate). The reaction is highly chemo- and stereoselective. A possible reaction mechanism involving a nickelacyclopentene intermediate is proposed.
authors: Department of Chemistry, National Tsing Hua University, Hsinchu, 30013 (Taiwan), Fax: (+886) 3572-4698.
authors: Chun-Ming
authors: CM
authors: Yang
authors: Subramaniyan
authors: S
authors: Mannathan
authors: Chien-Hong
authors: CH
authors: Cheng
keywords: cyclization; enynes; nickel; nickelacyclopentene; organoboronic acids