title: EURRECA-Estimating selenium requirements for deriving dietary reference values.
abstract: Current reference values for selenium, an essential micronutrient, are based on the intake of selenium that is required to achieve maximal glutathione peroxidase activity in plasma or erythrocytes. In order to assess the evidence of relevance to setting dietary reference values for selenium, the EURRECA Network of Excellence focused on systematic searches, review, and evaluation of (i) selenium status biomarkers and evidence for relationships between intake and status biomarkers, (ii) selenium and health (including the effect of intake and/or status biomarkers on cancer risk, immune function, HIV, cognition, and fertility), (iii) bioavailability of selenium from the diet, and (iv) impact of genotype/single nucleotide polymorphisms on status or health outcomes associated with selenium. The main research outputs for selenium and future research priorities are discussed further in this review.
authors: Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.
authors: Rachel
authors: R
authors: Hurst
authors: Rachel
authors: R
authors: Collings
authors: Linda J
authors: LJ
authors: Harvey
authors: Maria
authors: M
authors: King
authors: Lee
authors: L
authors: Hooper
authors: Jildau
authors: J
authors: Bouwman
authors: Mirjana
authors: M
authors: Gurinovic
authors: Susan J
authors: SJ
authors: Fairweather-Tait
mesh_terms: D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D019317:Evidence-Based Medicine; D006801:Humans; D015596:Nutrition Assessment; D018673:Nutrition Policy / Q000331:legislation & jurisprudence; D009752:Nutritional Status; D016032:Randomized Controlled Trials as Topic; D064167:Recommended Dietary Allowances / Q000331:legislation & jurisprudence*; D012016:Reference Values; D012643:Selenium / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D015415:Biomarkers; D012643:Selenium