title: SUMOylation of p53 mediates interferon activities.
abstract: There is growing evidence that many host proteins involved in innate and intrinsic immunity are regulated by SUMOylation, and that SUMO contributes to the regulatory process that governs the initiation of the type I interferon (IFN) response. The tumor suppressor p53 is a modulator of the IFN response that plays a role in virus-induced apoptosis and in IFN-induced senescence. Here we demonstrate that IFN treatment increases the levels of SUMOylated p53 and induces cellular senescence through a process that is partially dependent upon SUMOylation of p53. Similarly, we show that vesicular stomatitis virus (VSV) infection induces p53 SUMOylation, and that this modification favors the control of VSV replication. Thus, our study provides evidence that IFN signaling induces p53 SUMOylation, which results in the activation of a cellular senescence program and contributes to the antiviral functions of interferon.
authors: Departamento Biología Molecular y Celular; Centro Nacional de Biotecnología-CSIC; Madrid, Spain.
authors: Laura
authors: L
authors: Marcos-Villar
authors: José V
authors: JV
authors: Pérez-Girón
authors: Jéssica M
authors: JM
authors: Vilas
authors: Atenea
authors: A
authors: Soto
authors: Carlos F
authors: CF
authors: de la Cruz-Hererra
authors: Valerie
authors: V
authors: Lang
authors: Manuel
authors: M
authors: Collado
authors: Anxo
authors: A
authors: Vidal
authors: Manuel S
authors: MS
authors: Rodríguez
authors: César
authors: C
authors: Muñoz-Fontela
authors: Carmen
authors: C
authors: Rivas
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism; D045744:Cell Line, Tumor; D016922:Cellular Senescence / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D016898:Interferon-alpha / Q000378:metabolism* / Q000494:pharmacology; D008239:Lysine / Q000378:metabolism; D051379:Mice; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D058207:Sumoylation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D018116:Vesiculovirus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D025841:Small Ubiquitin-Related Modifier Proteins; D016159:Tumor Suppressor Protein p53; D008239:Lysine
keywords: SUMO; antiviral activity; interferon; p53; senescence
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