title: Chronological age vs biological age: an age-related normogram for antral follicle count, FSH and anti-Mullerian hormone.
abstract: OBJECTIVE
  To evaluate the correlation between chronological and biological age by comparing the normograms of AFC, AMH, and FSH.
  
  
  METHODS
  Retrospective study
  
  
  METHODS
  Data were taken from patients who visited the Infertility Clinic at Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia, between January 2008 and December 2010.
  
  
  METHODS
  Infertile women who visited the Infertility Clinic.
  
  
  METHODS
  None.
  
  
  METHODS
  Normogram of AFC (n = 366), AMH (n = 1616) and FSH (n = 415).
  
  
  RESULTS
  The correlations among AFC, AMH, FSH, and age are statistically significant. Normograms of AFC and AMH with 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles showed a decrease in age where FSH increased. A cut-off value of AFC, AMH, and FSH for poor responders was plotted at the 50th percentile of each normogram. Serum AMH and AFC started to decline in women between 34 and 35 years old. We found a relatively lower slope increase of FSH in older patients compared to that of AFC and AMH. FSH was observed to be a later predictor of biological age than AMH and AFC.
  
  
  CONCLUSIONS
  AMH predicted biological age earlier than FSH or AFC. Normograms can provide a reference guide for physicians to counsel infertile women. However, future validation with longitudinal data is still needed.
authors: Yasmin IVF Clinic - Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No.71, Jakarta, Indonesia, wiwekobudi@yahoo.co.id.
authors: Budi
authors: B
authors: Wiweko
authors: Dyah Mustikaning Pitha
authors: DM
authors: Prawesti
authors: Andon
authors: A
authors: Hestiantoro
authors: Kanadi
authors: K
authors: Sumapraja
authors: Muharam
authors: M
authors: Natadisastra
authors: Ali
authors: A
authors: Baziad
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D006080:Ovarian Follicle / Q000166:cytology / Q000378:metabolism; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
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