title: [Interest of selective progesterone receptor modulators in endometriosis].
abstract: The SPRM (selective progesterone receptor modulators) are agonists and/or antagonists of progesterone receptor. They are responsible for anovulation, amenorrhea and a lower prostaglandin levels, which leads to an improvement in pain and regression of lesions in endometriosis. On the endometrium, a particular aspect, the progesterone receptor modulator-associated endometrial changes (PAEC), raises additional studies to verify its harmlessness. However, due to the lack of hypoestrogenism and metabolic effects with these drugs, it is very likely that the SPRM will in the near future an important place in the treatment of endometriosis.
authors: Centre de gynécologie-obstétrique, centre d'AMP, CHU d'Amiens, 124, rue Camille-Desmoulins, 80054 Amiens cedex 1, France. Merviel.Philippe@chu-amiens.fr
authors: P
authors: P
authors: Merviel
authors: E
authors: E
authors: Lourdel
authors: S
authors: S
authors: Sanguin
authors: O
authors: O
authors: Gagneur
authors: R
authors: R
authors: Cabry
authors: A
authors: A
authors: Nasreddine
mesh_terms: D000568:Amenorrhea; D000818:Animals; D000858:Anovulation; D004715:Endometriosis / Q000188:drug therapy*; D004717:Endometrium / Q000187:drug effects; D005260:Female; D006727:Hormone Antagonists; D006801:Humans; D009640:Norethindrone / Q000737:chemistry; D009649:Norpregnadienes / Q000627:therapeutic use; D011374:Progesterone / Q000502:physiology; D011453:Prostaglandins / Q000032:analysis; D011980:Receptors, Progesterone / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D006727:Hormone Antagonists; D009649:Norpregnadienes; D011453:Prostaglandins; D011980:Receptors, Progesterone; D011374:Progesterone; D009640:Norethindrone; C555622:ulipristal acetate
keywords: Douleur pelvienne; Endometriosis; Endometrium; Endomètre; Endométriose; Pelvic pain; SPRM; Ulipristal acetate