title: Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice.
abstract: The aim of the study was to investigate the potential protective effect of ethanolic extract of Boswellia ovalifoliolata (BO) bark and leaf against doxorubicin (DOX)-induced cardiotoxicity in mice. Ethanolic extracts of BO bark (400 mg/kg) and leaves (250 mg/kg) were given orally to mice for 9 consecutive days and DOX (15 mg/kg; i.p.) was administered on the seventh day. Extract protected against DOX-induced ECG changes. It significantly inhibited DOX-provoked glutathione depletion and accumulation of malondialdehyde. The decrease in antioxidant enzyme activities of catalase, superoxide dismutase, glutathione peroxidase in cardiac tissue were significantly (p<0.05) mitigated after treatment with BO bark and leaf extracts. Pretreatment with BO significantly (p<0.05) restored the levels of DOX-induced rise of SGPT, SGOT, serum lactate dehydrogenase and creatine kinase-MB levels. These findings suggest that ethanolic extract of BO has protective effects against DOX-induced cardiotoxicity.
authors: Department of Pharmacology, A.U.College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam 530003, AP, India.
authors: Bandari
authors: B
authors: Uma Mahesh
authors: Shweta
authors: S
authors: Shrivastava
authors: Madhusudhana
authors: M
authors: Kuncha
authors: Bidya Dhar
authors: BD
authors: Sahu
authors: Challa Veerabhadra
authors: CV
authors: Swamy
authors: Rajeswara Rao
authors: RR
authors: Pragada
authors: V G M
authors: VG
authors: Naidu
authors: Ramakrishna
authors: R
authors: Sistla
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D029743:Boswellia / Q000737:chemistry*; D002316:Cardiotonic Agents; D002374:Catalase / Q000378:metabolism; D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000431:Ethanol; D005419:Flavonoids / Q000032:analysis; D016166:Free Radical Scavengers / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D006331:Heart Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000032:analysis; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012997:Solvents; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D001713:Biphenyl Compounds; D002316:Cardiotonic Agents; D005419:Flavonoids; D016166:Free Radical Scavengers; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D012997:Solvents; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D008315:Malondialdehyde; D004317:Doxorubicin; C004931:1,1-diphenyl-2-picrylhydrazyl; D002374:Catalase; D005978:Glutathione
keywords: Antioxidant; Boswellia ovalifoliolata; Cardioprotective; Doxorubicin