title: Fluorescein analogue xanthene-9-carboxylic acid: a transition-metal-free CO releasing molecule activated by green light.
abstract: 6-Hydroxy-3-oxo-3H-xanthene-9-carboxylic acid is introduced as the first transition-metal-free carbon monoxide releasing molecule activated by visible light (photoCORM). This water-soluble fluorescein analogue releases carbon monoxide in both water and methanol upon irradiation at 500 nm. When selectively irradiated in the presence of hemoglobin (Hb) under physiological conditions, released CO is quantitatively trapped to form carboxyhemoglobin (COHb). The reaction progress can be accurately monitored by characteristic absorption and emission properties of the reactants and products.
authors: Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
authors: Lovely Angel Panamparambil
authors: LA
authors: Antony
authors: Tomáš
authors: T
authors: Slanina
authors: Peter
authors: P
authors: Šebej
authors: Tomáš
authors: T
authors: Šolomek
authors: Petr
authors: P
authors: Klán
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry; D002263:Carboxyhemoglobin / Q000737:chemistry; D019793:Fluorescein / Q000737:chemistry; D008027:Light; D015394:Molecular Structure; D014867:Water / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry*
chemical_list: D014966:Xanthenes; D014867:Water; C036983:xanthene-9-carboxylic acid; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D019793:Fluorescein