title: Presynaptic proteoglycans: sweet organizers of synapse development.
abstract: Synaptic adhesion molecules control neuronal synapse development. In this issue of Neuron, Siddiqui et al. (2013) and de Wit et al. (2013) demonstrate that LRRTM4, a postsynaptic adhesion molecule, trans-synaptically interacts with presynaptic heparan sulfate proteoglycans (HSPGs) to promote synapse development.
authors: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon, 305-701, Korea.
authors: Yoo Sung
authors: YS
authors: Song
authors: Eunjoon
authors: E
authors: Kim
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D005260:Female; D053673:Glypicans / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D006624:Hippocampus; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D011247:Pregnancy; D013569:Synapses / Q000378:metabolism* / Q000502:physiology*
chemical_list: D053673:Glypicans; D019812:Heparan Sulfate Proteoglycans; C569562:LRRN4 protein, human; D009419:Nerve Tissue Proteins