title: [Lipid lowering therapy in geriatric patients].
abstract: Cardiovascular disease is also the most frequent cause of mortality in the elderly population. Invasive diagnostic and therapeutic interventions are performed at an increasing rate in older patients in order to maintain functional capacities and, thus, an adequate quality of life. Thus, strategies to prevent cardiovascular events (e.g., lipid lowering therapy) are also of great importance in elderly. With respect to the side effects of statin therapy, the risk of drug interaction has to be considered, as well as myopathy. Discrepant study results exist about the influence of statins on cognitive function. Retrospective analyses indicate that statin therapy might be related to an increased risk for type.2 diabetes in certain risk groups. The indication for statin therapy should, therefore, consider the risk profile and especially the individual situation of the older patient.
authors: Landeskrankenhaus Hochzirl, Anna-Dengel-Haus, 6170 Zirl, Österreich. Monika.lechleitner@tilak.at
authors: M
authors: M
authors: Lechleitner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000517:prevention & control; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000150:complications* / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents
references: Am J Epidemiol. 1996 Jan 15;143(2):151-8
references: 8546116
references: Vascul Pharmacol. 2013 Jul-Aug;59(1-2):11-8
references: 23702159
references: Curr Opin Cardiol. 2011 Jul;26(4):342-7
references: 21499090
references: Lancet. 2005 Jan 29-Feb 4;365(9457):434-41
references: 15680460
references: Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003160
references: 19370582
references: Lancet. 2011 Feb 12;377(9765):578-86
references: 21295847
references: Ann Intern Med. 1997 May 15;126(10):753-60
references: 9148647
references: J Am Coll Cardiol. 2010 Mar 30;55(13):1362-9
references: 20338498
references: Lancet. 2009 Apr 4;373(9670):1152-5
references: 19345816
references: Eur Heart J. 2012 Jul;33(13):1635-701
references: 22555213
references: JAMA. 2003 Apr 2;289(13):1681-90
references: 12672737
references: Circulation. 2002 Dec 17;106(25):3143-421
references: 12485966
references: J Am Geriatr Soc. 2008 Apr;56(4):621-9
references: 18205758
references: Arch Neurol. 2002 Feb;59(2):223-7
references: 11843693
references: J Am Coll Cardiol. 2008 Jan 1;51(1):37-45
references: 18174034
references: J Am Geriatr Soc. 2008 May;56(5):840-6
references: 18410327
references: Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):e149-61
references: 15297292
references: BMC Surg. 2012;12 Suppl 1:S15
references: 23173874
references: Ann Intern Med. 1998 Nov 1;129(9):681-9
references: 9841599
references: J Nutr Health Aging. 2010 May;14(5):387-92
references: 20424807
references: Curr Alzheimer Res. 2008 Aug;5(4):416-21
references: 18690839
references: Age Ageing. 2010 Nov;39(6):674-80
references: 20952373
references: Adv Nutr. 2012 Sep 01;3(5):711-7
references: 22983850
references: Obes Facts. 2013;6(1):9-16
references: 23434893
references: Arch Cardiovasc Dis. 2012 Dec;105(12):656-65
references: 23199621
references: Eur J Clin Pharmacol. 2013 Feb;69(2):261-7
references: 22706622
references: Lancet. 2000 Nov 11;356(9242):1627-31
references: 11089820
references: PLoS One. 2012;7(8):e41601
references: 22870234
references: Cochrane Database Syst Rev. 2013 Jan 31;(1):CD004816
references: 23440795
references: J Intern Med. 2003 Oct;254(4):353-62
references: 12974874
references: Circulation. 2007 Feb 13;115(6):681-3
references: 17296867
references: N Engl J Med. 2012 Jan 26;366(4):321-9
references: 22276822
references: Stroke. 2013 Feb;44(2):448-56
references: 23287777
references: Stroke. 2008 Apr;39(4):1084-9
references: 18309155
references: Ther Umsch. 2002 Jul;59(7):341-4
references: 12185949
references: BMJ. 2009 Jun 30;338:b2376
references: 19567909
references: J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M432-5
references: 12730252
references: Lancet. 2005 Oct 8;366(9493):1267-78
references: 16214597
references: Arch Intern Med. 1999 Aug 9-23;159(15):1670-8
references: 10448768
references: Clin Nutr. 2012 Feb;31(1):113-7
references: 21996512
references: CMAJ. 2008 Sep 23;179(7):645-52
references: 18809895
references: Neurorehabil Neural Repair. 2005 Sep;19(3):259-63
references: 16093417
references: Am J Cardiol. 1996 Apr 15;77(10):864-6
references: 8623741
references: Lancet. 2012 Aug 11;380(9841):581-90
references: 22607822
references: Exp Gerontol. 2009 Jan-Feb;44(1-2):112-22
references: 18579327
references: Curr Pharm Des. 2011;17(9):877-93
references: 21418034
references: Arch Intern Med. 2003 Jul 14;163(13):1549-54
references: 12860577
references: Am J Med. 2012 Sep;125(9):845-53
references: 22938925
references: Am J Geriatr Pharmacother. 2012 Aug;10(4):264-71
references: 22683398
references: Am J Cardiol. 2006 Jan 15;97(2):276-8
references: 16442378
references: Lancet. 2002 Nov 23;360(9346):1623-30
references: 12457784
references: Arch Intern Med. 2007 Mar 12;167(5):438-44
references: 17353490
references: Vasc Health Risk Manag. 2010 Apr 15;6:229-36
references: 20407630
references: Lancet. 2011 Dec 10;378(9808):2013-2020
references: 22115874
references: Circulation. 2013 Jan 1;127(1):143-52
references: 23283859
references: Am J Cardiol. 2012 Nov 15;110(10):1477-81
references: 22901970
references: J Am Coll Cardiol. 2013 Jul 2;62(1):21-9
references: 23644090
references: Ann Intern Med. 2001 May 15;134(10):931-40
references: 11352694
references: Am J Geriatr Pharmacother. 2012 Oct;10(5):296-302
references: 22921881
references: Geriatrics. 2003 May;58(5):35-6, 39-42
references: 12756679
references: Circulation. 1997 Jul 1;96(1):37-43
references: 9236414
references: Cochrane Database Syst Rev. 2009 Jul 08;(3):CD002091
references: 19588332
references: JAMA. 2004 Sep 22;292(12):1433-9
references: 15383513
references: Lancet. 2010 Nov 13;376(9753):1670-81
references: 21067804
references: Am J Cardiol. 2012 Jul 1;110(1 Suppl):3A-14A
references: 22697390