title: Cardiovascular autophagy: concepts, controversies, and perspectives.
abstract: Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been implicated in the pathogenesis of a wide range of heart pathologies. However, the precise role of autophagy in these contexts remains obscure owing to its multifarious actions. Here, we review recently derived insights regarding the role of autophagy in multiple manifestations of cardiac plasticity and disease.
authors: Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile; Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA.
authors: Sergio
authors: S
authors: Lavandero
authors: Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile.
authors: Rodrigo
authors: R
authors: Troncoso
authors: Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USA.
authors: Beverly A
authors: BA
authors: Rothermel
authors: Laboratory of Physiopharmacology; University of Antwerp; Antwerp, Belgium.
authors: Wim
authors: W
authors: Martinet
authors: Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA.
authors: Junichi
authors: J
authors: Sadoshima
authors: Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USA.
authors: Joseph A
authors: JA
authors: Hill
mesh_terms: D000818:Animals; D001343:Autophagy; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology
keywords: Cardiovascular system; atherosclerosis; autophagy; blood vessels; cardiac hypertrophy; cardiomyocyte; cardiovascular diseases; cell signaling; heart; heart failure; myocardial infarction; regulation; vascular muscle smooth cells