title: Different gestational ages and changing vulnerability of the premature brain.
abstract: In recent decades, there has been a general increase in survival rates of preterm and low birth weight infants, but this overall decrease in perinatal mortality has not been accompanied by a decrease in long-term physical and mental disability. In order to reduce the long-term sequelae of prematurity and to establish preventive measures, it is important to identify risk factors since the main determinant of specific vulnerability to different types of lesions is gestational age. The regional tissue vulnerability at a given gestational age is probably determined by the local metabolic requirements together with specific cell characteristics and their level of maturation. In this article, we discuss the most common neonatal cerebral lesions (cerebellar haemorrhage, germinal matrix intraventricular haemorrhage, periventricular leukomalacia, arterial ischaemic stroke, cerebral vein sinus thrombosis and hypoxic-ischaemic encephalopathy) related to the gestational age-dependent vulnerability of the premature brain.
authors: a Neonatal Intensive Care Unit , Istituto Giannina Gaslini , Genova , Italy .
authors: Andrea
authors: A
authors: Sannia
authors: a Neonatal Intensive Care Unit , Istituto Giannina Gaslini , Genova , Italy .
authors: Anna R
authors: AR
authors: Natalizia
authors: a Neonatal Intensive Care Unit , Istituto Giannina Gaslini , Genova , Italy .
authors: Alessandro
authors: A
authors: Parodi
authors: a Neonatal Intensive Care Unit , Istituto Giannina Gaslini , Genova , Italy .
authors: Mariya
authors: M
authors: Malova
authors: b NICU, Department of Clinical Sciences and Community Health , Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano , Milan , Italy , and.
authors: Monica
authors: M
authors: Fumagalli
authors: c Pediatric Neuroradiology Unit , Istituto Giannina Gaslini , Genova , Italy.
authors: Andrea
authors: A
authors: Rossi
authors: a Neonatal Intensive Care Unit , Istituto Giannina Gaslini , Genova , Italy .
authors: Luca A
authors: LA
authors: Ramenghi
mesh_terms: D001921:Brain / Q000196:embryology / Q000254:growth & development* / Q000503:physiopathology; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology*; D002550:Cerebral Veins; D002552:Cerebral Ventricles / Q000098:blood supply; D005865:Gestational Age; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology / Q000503:physiopathology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000473:pathology / Q000503:physiopathology*; D020300:Intracranial Hemorrhages; D007969:Leukomalacia, Periventricular / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000473:pathology / Q000503:physiopathology; D020521:Stroke / Q000473:pathology / Q000503:physiopathology
keywords: Cerebellar haemorrhage; GMH-IVH; HIE; PVL; gestational age; preterm; stroke