title: Long-term follow-up of coronary venous bypass graft lesions treated with a new generation drug-eluting stent with bioabsorbable polymer.
abstract: BACKGROUND
  To date, no published data are available regarding long-term follow-up of new generation DES implanted in coronary artery bypass graft (CABG) lesions.
  
  
  OBJECTIVE
  To assess the long-term clinical outcome of patients receiving the new generation Biolimus A9-coated drug-eluting stent (DES) with biodegradable polymer in saphenous vein grafts (SVG).
  
  
  METHODS
  Three thousand sixty-seven patients were included in the NOBORI 2 registry: 71 patients with a total of 117 lesions received at least 1 biolimus A9 DES in SVG lesions and 2,959 patients received percutaneous coronary intervention in other lesions. Clinical follow-up was performed at 1, 6, and 12 months, and annually up to 3 years.
  
  
  RESULTS
  Compared to the non-CABG group, patients with CABG lesions were older (P < 0.001), had a higher Charlson Comorbidity Index (P = 0.004), and presented more often with acute coronary syndrome (P = 0.02). At 3-year follow-up, cardiac death occurred in 9.7% versus 2.1% (P < 0.001), myocardial infarction (MI) in 8.3% versus 3.0% (P = 0.02), target lesion failure in 13.9% versus 6.4% (P = 0.03), and major adverse cardiac event in 18.1% versus 8.6% (P = 0.01). No differences were observed in TV-MI and TLR, nor stent thrombosis (ST) which was generally low in both groups (1.4% vs 0.8%, P = NS).
  
  
  CONCLUSIONS
  Albeit 3-year outcomes were less favorable in the CABG group, the higher cardiac mortality was apparently not driven by ST, target vessel MI, or TLR, but is likely due to advanced disease and age as well as comorbidity. The low TLR rate as well as the absence of late and very late ST suggest that BES are safe and effective for the treatment of CABG lesions.
authors: Zentrum für Herz-Gefaess- und Lungenmedizin Mediapark, Cologne, Germany.
authors: Rainer
authors: R
authors: Wessely
authors: Antonio
authors: A
authors: Marzocchi
authors: Harald
authors: H
authors: Schwacke
authors: Osmund
authors: O
authors: Bertel
authors: Peep
authors: P
authors: Laanmets
authors: Zoran
authors: Z
authors: Perisic
authors: Ralph
authors: R
authors: Toelg
authors: Nikola
authors: N
authors: Jagic
authors: Albrecht
authors: A
authors: Elsässer
authors: Gian Battista
authors: GB
authors: Danzi
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D001026:Coronary Artery Bypass; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011108:Polymers; D011446:Prospective Studies; D012501:Saphenous Vein; D016896:Treatment Outcome
chemical_list: D011108:Polymers