title: Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines.
abstract: A series of hybrid novel chloro (1a-9a) and dichloro (10b-18b) phenylthiazolyl-s-triazine were synthesized and subsequently subjected to their antibacterial activity against three gram positive viz. Lactobacillus casei (NCIM-2651); Bacillus cereus (NCIM-2458); Staphylococcus aureus (NCIM-2120) and three gram negative viz Salmonella typhimurium (NCIM-2501); Escherichia coli (NCIM-2065); Klebsiella aerogenes (NCIM-2098). The SAR studies around the lead compound revealed that introduction of electron withdrawing groups and amino (-NH-) and mercapto (-S-) linker bridge seemed more promising towards antibacterial activity. Moreover, the virtual Molinspiration screenings are in compliance with Ghose's rule.
authors: Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, India.
authors: Prashant
authors: P
authors: Gahtori
authors: Surajit Kumar
authors: SK
authors: Ghosh
authors: Brijesh
authors: B
authors: Singh
authors: Udaya Pratap
authors: UP
authors: Singh
authors: Hans Raj
authors: HR
authors: Bhat
authors: Archana
authors: A
authors: Uppal
keywords: Amines; Broth dilution assay; Linker bridge; MIC; s-Triazines
references: Eur J Med Chem. 2006 Nov;41(11):1240-6
references: 16815597
references: Eur J Med Chem. 2011 Feb;46(2):676-90
references: 21194812
references: Bioorg Med Chem Lett. 2010 Jan 1;20(1):322-5
references: 19910192
references: Indian J Pharm Sci. 2009 Jan;71(1):79-82
references: 20177467
references: Eur J Med Chem. 2010 Aug;45(8):3335-45
references: 20452706
references: J Antibiot (Tokyo). 2010 Aug;63(8):423-30
references: 20551985
references: Bioorg Med Chem Lett. 2006 Oct 15;16(20):5451-6
references: 16890435
references: Eur J Med Chem. 2006 May;41(5):611-5
references: 16540207
references: Nat Rev Drug Discov. 2010 Oct;9(10):751-2
references: 20885395
references: Nat Biotechnol. 2006 Dec;24(12):1521-8
references: 17160056