title: Contextual control of audiovisual integration in low-level sensory cortices.
abstract: Potential sources of multisensory influences on low-level sensory cortices include direct projections from sensory cortices of different modalities, as well as more indirect feedback inputs from higher order multisensory cortical regions. These multiple architectures may be functionally complementary, but the exact roles and inter-relationships of the circuits are unknown. Using a fully balanced context manipulation, we tested the hypotheses that: (1) feedforward and lateral pathways subserve speed functions, such as detecting peripheral stimuli. Multisensory integration effects in this context are predicted in peripheral fields of low-level sensory cortices. (2) Slower feedback pathways underpin accuracy functions, such as object discrimination. Integration effects in this context are predicted in higher-order association cortices and central/foveal fields of low-level sensory cortex. We used functional magnetic resonance imaging to compare the effects of central versus peripheral stimulation on audiovisual integration, while varying speed and accuracy requirements for behavioral responses. We found that interactions of task demands and stimulus eccentricity in low-level sensory cortices are more complex than would be predicted by a simple dichotomy such as our hypothesized peripheral/speed and foveal/accuracy functions. Additionally, our findings point to individual differences in integration that may be related to skills and strategy. Overall, our findings suggest that instead of using fixed, specialized pathways, the exact circuits and mechanisms that are used for low-level multisensory integration are much more flexible and contingent upon both individual and contextual factors than previously assumed.
authors: Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands; Neuroimaging and Neuromodeling Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York.
authors: Nienke M
authors: NM
authors: van Atteveldt
authors: Bradley S
authors: BS
authors: Peterson
authors: Charles E
authors: CE
authors: Schroeder
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000344:Afferent Pathways / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D005134:Eye Neoplasms; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: auditory cortex; eccentricity; fMRI; multisensory; task demand; visual cortex
references: Trends Cogn Sci. 2006 Jun;10(6):278-85
references: 16713325
references: Trends Cogn Sci. 2006 Nov;10(11):512-8
references: 17015029
references: Nat Neurosci. 2004 Nov;7(11):1190-2
references: 15475952
references: Nature. 1999 Jul 8;400(6740):162-6
references: 10408442
references: Neuropsychologia. 2007 Feb 1;45(3):531-9
references: 16797610
references: Exp Brain Res. 2005 Oct;166(3-4):559-71
references: 16028028
references: J Neurosci. 2007 Oct 24;27(43):11465-72
references: 17959789
references: Neuropsychologia. 2009 Mar;47(4):1045-52
references: 19041883
references: Atten Percept Psychophys. 2013 Apr;75(3):501-7
references: 23188734
references: Int J Psychophysiol. 2003 Oct;50(1-2):5-17
references: 14511832
references: Brain Res. 1987 Mar 10;405(2):268-83
references: 3567605
references: Exp Brain Res. 2009 Sep;198(2-3):221-31
references: 19352639
references: J Neurosci. 2009 Sep 23;29(38):11924-32
references: 19776278
references: Neuroscience. 2007 May 25;146(3):1371-87
references: 17395383
references: Neuropsychologia. 2009 Dec;47(14):3059-66
references: 19596021
references: J Cogn Neurosci. 2008 Dec;20(12):2125-36
references: 18457502
references: J Neurosci. 2010 Sep 22;30(38):12572-80
references: 20861363
references: Brain Res Cogn Brain Res. 2002 Jun;14(1):115-28
references: 12063135
references: Neurosci Lett. 2010 Jun 25;477(3):109-14
references: 20430065
references: Cereb Cortex. 2007 Jul;17(7):1672-9
references: 16968869
references: Cereb Cortex. 2010 Jul;20(7):1529-38
references: 19875677
references: Exp Brain Res. 2004 Oct;158(4):405-14
references: 15221173
references: J Comp Neurol. 2001 Dec 17;441(3):197-222
references: 11745645
references: Neuron. 2008 Jan 10;57(1):11-23
references: 18184561
references: Brain Struct Funct. 2007 Sep;212(2):121-32
references: 17717687
references: BMC Neurosci. 2008 Aug 12;9:79
references: 18699988
references: Magn Reson Med. 1995 May;33(5):636-47
references: 7596267
references: Neuroimage. 2007 Jul 15;36(4):1345-60
references: 17513133
references: J Comp Neurol. 2007 Jun 20;502(6):894-923
references: 17447261
references: Hear Res. 2009 Dec;258(1-2):152-64
references: 19500658
references: Neuron. 2004 Mar 4;41(5):809-23
references: 15003179
references: Hear Res. 2009 Dec;258(1-2):72-9
references: 19595755
references: J Cogn Neurosci. 2010 Jul;22(7):1583-96
references: 19583474
references: Neuroinformatics. 2005;3(2):93-113
references: 15988040
references: Exp Brain Res. 2009 Sep;198(2-3):183-94
references: 19352638
references: Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1181-6
references: 15647358
references: Cereb Cortex. 2007 Sep;17(9):2172-89
references: 17135481
references: Neuropsychologia. 2001;39(8):828-44
references: 11369406
references: J Neurosci. 2008 May 14;28(20):5344-9
references: 18480290
references: Eur J Neurosci. 2005 Dec;22(11):2886-902
references: 16324124
references: Neuron. 2004 Jul 22;43(2):271-82
references: 15260962
references: J Neurosci. 2010 Feb 17;30(7):2662-75
references: 20164350
references: J Cogn Neurosci. 2013 Jul;25(7):1122-35
references: 23384192
references: Brain. 2007 Nov;130(Pt 11):2929-41
references: 17906328
references: Neuron. 2007 Jan 18;53(2):279-92
references: 17224408
references: Cereb Cortex. 2009 Sep;19(9):2025-37
references: 19150924
references: Proc Natl Acad Sci U S A. 2006 May 23;103(21):8239-44
references: 16702554
references: Hum Brain Mapp. 2006 May;27(5):392-401
references: 16596654
references: J Comp Neurol. 2007 Jun 20;502(6):924-52
references: 17444488
references: J Neurophysiol. 2005 May;93(5):2575-86
references: 15634709
references: J Neurosci. 2007 Jul 25;27(30):7881-7
references: 17652579
references: J Cogn Neurosci. 2007 Dec;19(12):1964-73
references: 17892381
references: J Neurosci. 2002 Jul 1;22(13):5749-59
references: 12097528
references: Exp Brain Res. 2009 Sep;198(2-3):153-64
references: 19533111
references: Cereb Cortex. 2009 Jul;19(7):1641-53
references: 19015373
references: Neuroimage. 2004 Jun;22(2):706-19
references: 15193599
references: Brain Res. 2008 Nov 25;1242:136-50
references: 18479672
references: Cereb Cortex. 2007 Apr;17(4):962-74
references: 16751298
references: Brain Res Cogn Brain Res. 2002 Jun;14(1):20-30
references: 12063127
references: J Vis. 2003;3(10):586-98
references: 14640882
references: Cogn Psychol. 1982 Apr;14(2):247-79
references: 7083803
references: Exp Brain Res. 2005 Oct;166(3-4):289-97
references: 15988597
references: J Neurosci. 2012 Jan 25;32(4):1171-82
references: 22279203
references: Exp Psychol. 2008;55(2):121-32
references: 18444522
references: Cereb Cortex. 2008 Oct;18(10):2439-49
references: 18281303
references: Exp Brain Res. 2006 Jun;172(1):57-66
references: 16369788
references: Front Integr Neurosci. 2009 Mar 11;3:2
references: 19404410
references: Neuroscience. 2006 Dec 28;143(4):1065-83
references: 17027173
references: Neuroreport. 2001 Dec 4;12(17):3849-52
references: 11726807
references: J Neurophysiol. 2008 Nov;100(5):2712-8
references: 18799604
references: Curr Biol. 2009 Nov 17;19(21):1799-805
references: 19836243
references: Int J Psychophysiol. 2003 Oct;50(1-2):19-26
references: 14511833
references: J Cogn Neurosci. 1999 Sep;11(5):473-90
references: 10511637
references: Eur J Neurosci. 2010 May;31(10):1772-82
references: 20584181
references: Cereb Cortex. 2001 Dec;11(12):1110-23
references: 11709482