title: IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection.
abstract: The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway's immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia (K. pneumonia) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection.
authors: Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA.
authors: Hsing-Chuan
authors: HC
authors: Tsai
authors: Sharlene
authors: S
authors: Velichko
authors: Li-Yin
authors: LY
authors: Hung
authors: Reen
authors: R
authors: Wu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000378:metabolism*; D011014:Pneumonia / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D053722:Receptors, Interleukin-17 / Q000378:metabolism; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17
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