title: Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.
abstract: We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres. We identified, for the first time, that two dietary flavones, acacetin and chrysin, are able to specifically alleviate TPE in human cells. We further investigated their influence on telomere integrity and showed that both drugs drastically deprotect telomeres against DNA damage response. However, telomere deprotection triggered by shelterin dysfunction does not affect TPE, indicating that acacetin and chrysin target several functions of telomeres. These results show that TPE-based screening assays represent valuable methods to discover new compounds targeting telomeres.Molecular Therapy-Nucleic Acids (2013) 2, e116; doi:10.1038/mtna.2013.42; published online 20 August 2013.
authors: Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, UCBL1, IFR128, 46 allée d'Italie, Lyon Cedex 07, France.
authors: Amina
authors: A
authors: Boussouar
authors: Caroline
authors: C
authors: Barette
authors: Robert
authors: R
authors: Nadon
authors: Adelaïde
authors: A
authors: Saint-Léger
authors: Natacha
authors: N
authors: Broucqsault
authors: Alexandre
authors: A
authors: Ottaviani
authors: Arva
authors: A
authors: Firozhoussen
authors: Yiming
authors: Y
authors: Lu
authors: Laurence
authors: L
authors: Lafanechère
authors: Eric
authors: E
authors: Gilson
authors: Frédérique
authors: F
authors: Magdinier
authors: Jing
authors: J
authors: Ye
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