title: Evaluation of extemporaneous oral itraconazole suspensions by dissolution profiles mapping.
abstract: The objective of this study was to evaluate by dissolution profiles mapping five extemporaneous oral itraconazole suspensions reported in the literature. Dissolution profiles of the extemporaneous oral itraconazole preparations were mapped and correlated with their reported clinical data therein. Four out of five extemporaneous preparations had either too early or insufficient release of itraconazole during the dissolution study, potentially limiting the in vivo oral bioavailability in patients. Dissolution profiles in the remaining extemporaneous preparation was closely similar to that in commercial itraconazole capsules. Based on the reported clinical data and dissolution results in this study, the extemporaneous preparation proposed in a study by Ong and Fobes seems to be the most reasonable choice for our patients. Dissolution profile evaluation is an important quality-control parameter during the evaluation of extemporaneous preparations by pharmacists.
authors: School of Health Sciences Macao Polytechnic Institute, Macao SAR, China.
authors: Henry H Y
authors: HH
authors: Tong
authors: Hokman
authors: H
authors: Chan
authors: Zhen
authors: Z
authors: Du
authors: Ying
authors: Y
authors: Zheng