title: Myocardial perfusion imaging with cardiac computed tomography: state of the art.
abstract: Cardiac computed tomography (CCT) has become an important tool for the anatomic assessment of patients with suspected coronary disease. Its diagnostic accuracy for detecting the presence of underlying coronary artery disease and ability to risk stratify patients are well documented. However, the role of CCT for the physiologic assessment of myocardial perfusion during resting and stress conditions is only now emerging. With the addition of myocardial perfusion imaging to coronary imaging, CCT has the potential to assess both coronary anatomy and its functional significance with a single non-invasive test. In this review, we discuss the current state of CCT myocardial perfusion imaging for the detection of myocardial ischemia and myocardial infarction and examine its complementary role to CCT coronary imaging.
authors: Department of Medicine, Section of Cardiology, Cardiac Imaging Center, University of Chicago, Medical Center, 5841 South Maryland Avenue, MC5084, Chicago, IL, 60637, USA, amitpatel@uchicago.edu.
authors: Amit R
authors: AR
authors: Patel
authors: Nicole M
authors: NM
authors: Bhave
authors: Victor
authors: V
authors: Mor-Avi
mesh_terms: D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
references: Invest Radiol. 2010 Jun;45(6):298-305
references: 20421799
references: Int J Cardiovasc Imaging. 2010 Mar;26(3):345-54
references: 19908161
references: Heart. 2012 Oct;98(20):1510-7
references: 22895647
references: Am J Cardiol. 2009 Aug 1;104(3):318-26
references: 19616661
references: Radiology. 2004 Jun;231(3):697-701
references: 15118118
references: JACC Cardiovasc Imaging. 2010 Oct;3(10):1010-9
references: 20947046
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):382-91
references: 22146497
references: J Am Coll Cardiol. 2005 Jun 21;45(12):2042-7
references: 15963407
references: Eur Radiol. 2012 Dec;22(12):2654-61
references: 22752461
references: Eur J Nucl Med Mol Imaging. 2012 Dec;39(12):1920-6
references: 22926710
references: Med Phys. 2009 Dec;36(12):5683-94
references: 20095281
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):459-66
references: 22146505
references: Circ Cardiovasc Imaging. 2011 Sep;4(5):540-9
references: 21862731
references: Am J Cardiol. 2010 Aug 1;106(3):310-5
references: 20643238
references: Lancet. 2003 Feb 1;361(9355):374-9
references: 12573373
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):443-8
references: 22146503
references: J Am Coll Cardiol. 2009 Sep 15;54(12):1072-84
references: 19744616
references: Radiology. 2012 Nov;265(2):576-83
references: 22893711
references: Circ J. 2008 Jul;72(7):1086-91
references: 18577816
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):449-58
references: 22146504
references: J Cardiovasc Comput Tomogr. 2010 Mar-Apr;4(2):99-107
references: 20060800
references: J Cardiovasc Comput Tomogr. 2011 Jul-Aug;5(4):247-54
references: 21723516
references: J Nucl Cardiol. 2011 Feb;18(1):96-103
references: 21128040
references: Med Phys. 2012 Jul;39(7):4079-92
references: 22830741
references: J Cardiovasc Comput Tomogr. 2013 Jan-Feb;7(1):51-7
references: 23333188
references: Am Heart J. 2010 Sep;160(3):528-34
references: 20826263
references: AJR Am J Roentgenol. 2012 Mar;198(3):521-9
references: 22357991
references: Eur Radiol. 2009 Aug;19(8):1897-905
references: 19280193
references: J Am Coll Cardiol. 2013 Mar 12;61(10):1099-107
references: 23375929
references: Am J Cardiol. 1974 Jul;34(1):48-55
references: 4835753
references: Circ Cardiovasc Imaging. 2012 May 1;5(3):333-40
references: 22447807
references: Eur Radiol. 2005 May;15(5):864-71
references: 15776243
references: Coron Artery Dis. 2013 Jun;24(4):290-7
references: 23442945
references: Radiology. 2010 Jul;256(1):111-8
references: 20574089
references: N Engl J Med. 2012 Apr 12;366(15):1393-403
references: 22449295
references: Invest Radiol. 2007 Dec;42(12):815-22
references: 18007153
references: Invest Radiol. 2010 Jun;45(6):306-13
references: 20421800
references: Radiology. 2012 Sep;264(3):876-83
references: 22771879
references: N Engl J Med. 2008 Nov 27;359(22):2324-36
references: 19038879
references: Eur J Radiol. 2012 Oct;81(10):2648-57
references: 22209631
references: Heart. 2013 Jul;99(14):1004-11
references: 23674364
references: Circ J. 2012;76(7):1799-801
references: 22664799
references: J Cardiovasc Comput Tomogr. 2012 Jan-Feb;6(1):14-23
references: 22210535
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):370-81
references: 22146496
references: Med Phys. 2012 Jan;39(1):214-23
references: 22225290
references: Eur Heart J. 2008 Oct;29(20):2544-51
references: 18762553
references: J Am Coll Cardiol. 2006 Jul 4;48(1):153-60
references: 16814661
references: Circulation. 2003 Jun 17;107(23):2900-7
references: 12771008
references: Circulation. 1976 Mar;53(3):490-3
references: 1248081
references: J Am Coll Cardiol. 2011 Aug 16;58(8):849-60
references: 21835321
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):421-9
references: 22146501
references: Eur Radiol. 2011 Oct;21(10):2091-9
references: 21573970
references: Int J Cardiovasc Imaging. 2013 Oct;29(7):1585-93
references: 23653247
references: JACC Cardiovasc Imaging. 2012 Nov;5(11):1097-111
references: 23153909
references: Circ Cardiovasc Imaging. 2009 May;2(3):174-82
references: 19808590
references: J Nucl Cardiol. 2010 Aug;17(4):625-30
references: 20473650
references: Invest Radiol. 1978 Mar-Apr;13(2):103-9
references: 77854
references: Eur Radiol. 2012 Jan;22(1):39-50
references: 21938441
references: Int J Cardiovasc Imaging. 2013 Apr;29(4):875-84
references: 23076604
references: Eur J Radiol. 2012 Dec;81(12):3703-10
references: 21194865
references: Circ J. 2009 May;73(5):905-11
references: 19325193
references: N Engl J Med. 2009 Jan 15;360(3):213-24
references: 19144937
references: AJR Am J Roentgenol. 2008 Jul;191(1):19-25
references: 18562719
references: Invest Radiol. 2012 Jan;47(1):71-7
references: 22178894
references: Invest Radiol. 2010 Jun;45(6):314-23
references: 20440212
references: Radiology. 2010 Feb;254(2):410-9
references: 20093513
references: Radiology. 2011 Sep;260(3):689-98
references: 21846761
references: Clin Cardiol. 2011 Jul;34(7):454-60
references: 21660991
references: J Am Coll Cardiol. 2006 Jul 4;48(1):144-52
references: 16814660
references: N Engl J Med. 2012 Jul 26;367(4):299-308
references: 22830462
references: Eur Heart J. 2012 Jan;33(1):67-77
references: 21810860
references: J Comput Assist Tomogr. 2012 Jul-Aug;36(4):443-9
references: 22805675
references: AJR Am J Roentgenol. 2012 Mar;198(3):512-20
references: 22357990
references: JACC Cardiovasc Imaging. 2010 Aug;3(8):811-20
references: 20705260
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):412-20
references: 22146500
references: Phys Med Biol. 2009 May 21;54(10):3031-50
references: 19398817
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):357-69
references: 22146495
references: J Am Coll Cardiol. 2012 Feb 21;59(8):730-8
references: 22340265
references: Eur Radiol. 2013 Jul;23(7):1812-21
references: 23430194
references: J Nucl Cardiol. 2010 Jan-Feb;17(1):27-37
references: 19936863
references: JACC Cardiovasc Imaging. 2012 Aug;5(8):829-36
references: 22897997
references: Eur J Radiol. 2012 Dec;81(12):3719-25
references: 21277132
references: AJR Am J Roentgenol. 2013 Feb;200(2):337-42
references: 23345355
references: IEEE Trans Inf Technol Biomed. 2012 Sep;16(5):842-51
references: 22711778
references: Eur Radiol. 2010 Jul;20(7):1607-14
references: 20155270
references: Eur Radiol. 2011 Jan;21(1):26-35
references: 20658242
references: Am J Cardiol. 2009 Jun 1;103(11):1487-94
references: 19463504
references: Int J Cardiol. 2013 Sep 30;168(2):739-45
references: 23102604
references: Circ J. 2011;75(8):1905-12
references: 21697608
references: AJR Am J Roentgenol. 2011 Oct;197(4):829-37
references: 21940569
references: Eur Radiol. 2010 Feb;20(2):337-47
references: 19711083
references: Heart. 2006 Dec;92(12):1779-83
references: 16740917
references: J Cardiovasc Comput Tomogr. 2011 Nov-Dec;5(6):392-405
references: 22146498