title: Reciprocal relationship between plasma ghrelin level and arterial stiffness in hypertensive subjects.
abstract: Arterial stiffness, considered an independent predictor of cardiovascular morbidity and mortality, is closely associated with hypertension. Futhermore, the role of ghrelin in the development of hypertension has been widely recognized. The purpose of the present study was to explore the potential relationship between circulating ghrelin and arterial stiffness in hypertensive subjects. A total of 192 patients with primary hypertension and 107 normotensive (NT) control subjects were enrolled in the present cross-sectional study. Plasma ghrelin was determined by ELISA. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) and the augmentation index (AIx). Both baPWV and AIx values were markedly higher in the hypertensive compared with NT group (P < 0.01). In contrast, plasma ghrelin concentrations were significantly lower in hypertensive patients compared with NT subjects (P < 0.01). Plasma ghrelin concentrations were negatively correlated with age (odds ratio (OR) -1.836; P < 0.001), smoking (OR -1.347; P = 0.042), baPWV (OR -1.762; P < 0.001) and AIx (OR -1.516; P = 0.005), but positively associated with fasting plasma glucose (OR 1.293; P = 0.047) and HbA1c (OR 1.413; P = 0.025). The inverse correlation between circulating ghrelin and the extent of arterial stiffness suggests that ghrelin is an independent determinant of arterial stiffness, even after adjustment for confounding cardiovascular risk factors, and it actively participates in the pathophysiology of arterial stiffness in hypertensive subjects.
authors: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors: Yin-Tao
authors: YT
authors: Zhao
authors: Hai-Bo
authors: HB
authors: Yang
authors: Ling
authors: L
authors: Li
authors: Ke
authors: K
authors: Gao
authors: Peng-Fei
authors: PF
authors: Li
authors: Wei-Wei
authors: WW
authors: Xie
mesh_terms: D000368:Aged; D001158:Arteries / Q000378:metabolism / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054439:Ghrelin / Q000097:blood* / Q000378:metabolism; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D014655:Vascular Resistance; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; C515349:GHRL protein, human; D054439:Ghrelin
keywords: arterial stiffness; augmentation index; circulating ghrelin; hypertension; pulse wave velocity