title: Latency locus complements MicroRNA 155 deficiency in vivo.
abstract: MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155.
authors: Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors: Sang-Hoon
authors: SH
authors: Sin
authors: Yong Baek
authors: YB
authors: Kim
authors: Dirk P
authors: DP
authors: Dittmer
mesh_terms: D000818:Animals; D005816:Genetic Complementation Test; D018858:Germinal Center; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000276:immunology; D054884:Host-Pathogen Interactions; D007136:Immunoglobulins / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics*; D010581:Peyer's Patches / Q000276:immunology / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D007136:Immunoglobulins; D035683:MicroRNAs; C532623:Mirn155 microRNA, mouse; D012367:RNA, Viral
references: Immunity. 2007 Dec;27(6):847-59
references: 18055230
references: Science. 2007 Apr 27;316(5824):604-8
references: 17463289
references: Blood. 2009 Jun 4;113(23):5938-41
references: 19252139
references: J Exp Med. 1999 Dec 20;190(12):1857-68
references: 10601360
references: J Virol. 2002 Jun;76(12):6213-23
references: 12021355
references: J Clin Invest. 2011 Feb;121(2):752-68
references: 21245574
references: Cell Host Microbe. 2011 Nov 17;10(5):515-26
references: 22100165
references: Nature. 2007 Dec 13;450(7172):1096-9
references: 18075594
references: PLoS One. 2012;7(11):e49435
references: 23185331
references: Nucleic Acids Res. 2008 Nov;36(20):6608-19
references: 18940871
references: Gene. 2001 Aug 22;274(1-2):157-67
references: 11675008
references: J Virol. 2010 Nov;84(22):11670-8
references: 20844043
references: J Virol. 2010 Oct;84(20):10653-60
references: 20686032
references: Blood. 2008 Feb 15;111(4):2347-53
references: 18079361
references: Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32
references: 15738415
references: J Virol. 2007 Dec;81(23):12836-45
references: 17881434
references: PLoS Pathog. 2010 Jan 29;6(1):e1000742
references: 20126446
references: Science. 2007 Apr 27;316(5824):608-11
references: 17463290
references: J Virol. 2011 Oct;85(19):9877-86
references: 21813606
references: J Virol. 1998 Oct;72(10):8309-15
references: 9733875
references: J Virol. 2008 Nov;82(21):10436-43
references: 18753206
references: PLoS Pathog. 2011 Feb;7(2):e1001305
references: 21383974
references: J Virol. 2002 Nov;76(21):11024-32
references: 12368345
references: J Virol. 2008 Jun;82(11):5295-306
references: 18367535
references: Genes Chromosomes Cancer. 2004 Feb;39(2):167-9
references: 14695998
references: Blood. 2013 Apr 11;121(15):2952-63
references: 23365457
references: PLoS Pathog. 2012;8(8):e1002884
references: 22927820
references: J Virol. 2009 Jan;83(1):489-92
references: 18945769
references: Proc Natl Acad Sci U S A. 2006 May 2;103(18):7024-9
references: 16641092
references: J Clin Invest. 2006 Mar;116(3):735-42
references: 16498502
references: Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11558-62
references: 8524803
references: Genes Chromosomes Cancer. 2003 May;37(1):20-8
references: 12661002