title: Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis.
abstract: BACKGROUND
  The I405V polymorphism of the cholesteryl ester transfer protein gene (CETP) has been suggested to be a protective factor conferring longevity in Ashkenazi Jews, although findings in other races are not supportive. This paper describes a case-control study and a meta-analysis conducted to derive a more precise estimation of the association between CETP 405V and longevity.
  
  
  METHODS
  We enrolled 1,021 ethnic Han Chinese participants (506 in the longevity group and 515 controls), then performed a meta-analysis that integrated the current study and previously published ones. Pooled odds ratios (OR) were calculated for allele contrasts, dominant and recessive inheritance models to assess the association between CETP 405V and longevity according to the ethnic stratification.
  
  
  RESULTS
  Our case-control data indicated that CETP 405V is a longevity risk allele in all genetic models (P additive =0.008; P dominant =0.008, OR(dominant)=0.673; P recessive =0.017, OR(recessive)=0.654) after adjustment for the apolipoprotein E (APOE) ε4 allele, body mass index and high-density lipoprotein cholesterol. A synergy was detected between 405V and APOE ε4 (P=0.001, OR=0.530). Eight studies were eligible for meta-analysis, which confirmed 405V is the risky allele against longevity in all genetic models: allele contrasts (OR=0.81, 95%CI=0.74-0.88), dominant model (OR=0.72, 95%CI=0.64-0.82) and recessive model (OR=0.80, 95%CI=0.67-0.96). After ethnic stratification, 405V remained a risk allele in East Asians but no significant association was found in Europeans or white Americans.
  
  
  CONCLUSIONS
  Our case-control study suggests CETP 405V as a risk allele against longevity in Chinese. The meta-analysis suggests the involvement of CETP 405V is protective in Ashkenazi Jews but is a risk allele against longevity in the East Asian (Chinese) population.
authors: The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors: Liang
authors: L
authors: Sun
authors: Cai-you
authors: CY
authors: Hu
authors: Xiao-hong
authors: XH
authors: Shi
authors: Chen-guang
authors: CG
authors: Zheng
authors: Ze-zhi
authors: ZZ
authors: Huang
authors: Ze-ping
authors: ZP
authors: Lv
authors: Jin
authors: J
authors: Huang
authors: Gang
authors: G
authors: Wan
authors: Ke-yan
authors: KY
authors: Qi
authors: Si-ying
authors: SY
authors: Liang
authors: Lin
authors: L
authors: Zhou
authors: Ze
authors: Z
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008076:Cholesterol, HDL / Q000235:genetics; D003710:Demography; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008136:Longevity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D017594:Publication Bias; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D014280:Triglycerides
references: J Lipid Res. 1998 May;39(5):1071-8
references: 9610775
references: Arch Gerontol Geriatr. 2006 Sep-Oct;43(2):213-21
references: 16384616
references: Bioinformatics. 2003 Jan;19(1):149-50
references: 12499305
references: J Mol Neurosci. 2005;25(1):95-103
references: 15781970
references: Nature. 2012 Dec 6;492(7427):S6-8
references: 23222673
references: Biogerontology. 2008 Apr;9(2):85-92
references: 18034366
references: Lancet. 2001 Aug 4;358(9279):351-5
references: 11502313
references: J Clin Epidemiol. 2009 Oct;62(10):1006-12
references: 19631508
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: JAMA. 2003 Oct 15;290(15):2030-40
references: 14559957
references: J Clin Invest. 1999 Apr;103(8):1191-9
references: 10207171
references: Am J Epidemiol. 2002 Aug 15;156(4):300-10
references: 12181099
references: Am J Hum Genet. 2005 Feb;76(2):268-75
references: 15625622
references: PLoS Med. 2006 Dec;3(12):e495
references: 17194192
references: PLoS Med. 2009 Jul 21;6(7):e1000100
references: 19621070
references: Contemp Clin Trials. 2007 Feb;28(2):105-14
references: 16807131
references: JAMA. 2010 Jan 13;303(2):150-8
references: 20068209
references: Hum Genet. 1996 Mar;97(3):319-23
references: 8786073
references: Atheroscler Suppl. 2002 Dec;3(4):39-47
references: 12573362
references: Diabet Med. 2006 Oct;23(10):1085-92
references: 16978372
references: Am J Public Health. 2008 Jul;98(7):1203-8
references: 18511735
references: Nat Genet. 2001 Nov;29(3):306-9
references: 11600885
references: Curr Gerontol Geriatr Res. 2010;2010:380460
references: 21490698
references: Mech Ageing Dev. 2005 Jun-Jul;126(6-7):826-8
references: 15888337
references: Angiology. 2014 Mar;65(3):210-5
references: 23389097
references: PLoS One. 2013;8(3):e56564
references: 23483888
references: Inflamm Res. 2012 Jan;61(1):43-51
references: 21979869
references: J Gerontol A Biol Sci Med Sci. 2010 May;65(5):478-87
references: 20304771
references: Am J Clin Nutr. 2006 Feb;83(2):484S-487S
references: 16470017
references: Ann N Y Acad Sci. 2006 May;1067:252-63
references: 16803995
references: JAMA. 2008 Jun 18;299(23):2777-88
references: 18560005
references: J Gerontol A Biol Sci Med Sci. 2012 May;67(5):503-10
references: 22499764