title: Value of positron emission tomography/computed tomography in diagnosis and staging of primary ocular and orbital tumors.
abstract: Accurate and reliable staging methods are crucial for optimal care of patients with ocular and orbital malignancies. Positron emission tomography/computed tomography (PET/CT) has recently emerged as a staging tool in the field of ophthalmic oncology. For detecting primary ocular or orbital lesions, PET/CT does not seem to provide an advantage over clinical ophthalmologic examination or conventional imaging studies such as CT or magnetic resonance imaging of the orbit. However, PET/CT may detect distant metastatic lesions that conventional imaging studies miss. For orbital and ocular adnexal lymphoma, use of PET/CT has been proven to be feasible and is now accepted both as a standard part of the initial staging work-up and for the assessment of response to therapy. For other ophthalmic tumors, PET/CT seems most appropriate for advanced metastatic tumors of the orbit, eyelid, and eye, for which the detection of distant metastasis with 1 comprehensive study may be preferable to performing multiple CT scans with contrast.
authors: Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA ; The University of Texas Medical School at Houston, Houston, TX, USA.
authors: Ka-Hoi
authors: KH
authors: Hui
authors: Margaret L
authors: ML
authors: Pfeiffer
authors: Bita
authors: B
authors: Esmaeli
keywords: Cancer staging; MALT lymphoma; Orbital lymphoma; Orbital tumors; Positron emission tomography/computed tomography; Uveal melanoma
references: J Clin Oncol. 2006 Mar 1;24(7):1178-87
references: 16505438
references: Cancer. 1999 Mar 1;85(5):1151-9
references: 10091801
references: Ophthalmology. 2006 Oct;113(10):1854-8
references: 16860867
references: Br J Ophthalmol. 2005 Oct;89(10):1265-9
references: 16170113
references: Optometry. 2007 Aug;78(8):396-401
references: 17662928
references: Q J Nucl Med Mol Imaging. 2004 Jun;48(2):66-75
references: 15243404
references: Nuklearmedizin. 2008;47(2):73-9
references: 18392316
references: Br J Ophthalmol. 2005 Oct;89(10):1270-4
references: 16170114
references: Br J Ophthalmol. 2006 Oct;90(10):1263-6
references: 16837539
references: J Nucl Med. 2004 Jan;45 Suppl 1:72S-81S
references: 14736838
references: Cancer. 1974 Oct;34(4):1001-4
references: 4424282
references: Clin Nucl Med. 2010 Dec;35(12):962-4
references: 21206233
references: Melanoma Res. 2010 Dec;20(6):511-6
references: 20890225
references: Eur J Nucl Med Mol Imaging. 2009 Nov;36(11):1774-82
references: 19495748
references: Ophthalmic Surg Lasers Imaging. 2007 Jul-Aug;38(4):319-25
references: 17674923
references: Semin Nucl Med. 2003 Jul;33(3):193-204
references: 12931321
references: Semin Nucl Med. 2008 May;38(3):152-66
references: 18396176
references: Am J Ophthalmol. 2005 Aug;140(2):193-9
references: 15992753
references: Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):759-60
references: 17219120
references: Clin Nucl Med. 2011 Oct;36(10):e127-38
references: 21892025
references: Clin Nucl Med. 2010 Apr;35(4):260-2
references: 20305416
references: Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):137-42
references: 20395070
references: J Craniomaxillofac Surg. 2006 Jan;34(1):9-16
references: 16343913
references: Arch Ophthalmol. 2007 Dec;125(12):1663-7
references: 18071119
references: Radiology. 2006 Feb;238(2):405-22
references: 16436809
references: Arch Ophthalmol. 1990 Sep;108(9):1268-73
references: 2205183
references: Clin Nucl Med. 2012 May;37(5):516-9
references: 22475910
references: Ann Hematol. 2005 Jan;84(1):13-8
references: 15309523
references: Mol Imaging Biol. 2006 Jul-Aug;8(4):212-7
references: 16724293
references: J Clin Oncol. 2004 Jun 15;22(12):2438-44
references: 15197206
references: Blood. 2008 Jan 15;111(2):504-16
references: 17916746
references: J Nucl Med. 2012 Feb;53(2):191-8
references: 22251556
references: Am J Ophthalmol. 2005 Oct;140(4):612-7
references: 16226513
references: Cardiovasc Intervent Radiol. 2013 Feb;36(1):158-65
references: 22526099
references: Nucl Med Commun. 2010 Nov;31(11):925-30
references: 20856153
references: Ophthalmol Clin North Am. 2005 Mar;18(1):143-50, ix
references: 15763199
references: Int J Dermatol. 2008 Mar;47(3):276-9
references: 18289332
references: Radiol Clin North Am. 2008 Mar;46(2):199-211, vii
references: 18619376
references: Ophthalmology. 1991 Mar;98(3):383-9; discussion 390
references: 2023760
references: Br J Ophthalmol. 2008 Apr;92(4):479-82
references: 18369064
references: Korean J Radiol. 2009 Jan-Feb;10(1):1-7
references: 19182496
references: Postgrad Med J. 2010 Mar;86(1013):174-82
references: 20237012
references: Eye (Lond). 1998;12 ( Pt 6):945-8
references: 10325992
references: Clin Nucl Med. 2009 Sep;34(9):589-93
references: 19692819
references: J Surg Oncol. 2012 Nov;106(6):708-12
references: 22674652
references: Melanoma Res. 2012 Feb;22(1):63-9
references: 22027909
references: Am J Ophthalmol. 2005 Sep;140(3):531-3
references: 16139007
references: Head Neck. 2012 Sep;34(9):1205-11
references: 22038900
references: Ophthalmology. 2011 Sep;118(9):1881-5
references: 21704381
references: Cancer. 1972 Jan;29(1):252-60
references: 5007387