title: Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans.
abstract: BACKGROUND
  GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study.
  
  
  METHODS
  GLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.
  
  
  RESULTS
  GLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C (low density lipoprotein cholesterol), hsCRP (high-sensitive C-reactive protein), and eGFR (estimated glomerular filtration rate) (OR: 2.53 (95% CI: 1.12 - 6.08; p = 0.03).
  
  
  CONCLUSIONS
  Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations.
authors: Department of Internal Medicine I, University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. mlehrke@ukaachen.de.
authors: Katja
authors: K
authors: Piotrowski
authors: Melanie
authors: M
authors: Becker
authors: Julia
authors: J
authors: Zugwurst
authors: Ingeborg
authors: I
authors: Biller-Friedmann
authors: Gerald
authors: G
authors: Spoettl
authors: Martin
authors: M
authors: Greif
authors: Alexander W
authors: AW
authors: Leber
authors: Alexander
authors: A
authors: Becker
authors: Rüdiger P
authors: RP
authors: Laubender
authors: Corinna
authors: C
authors: Lebherz
authors: Burkhard
authors: B
authors: Goeke
authors: Nikolaus
authors: N
authors: Marx
authors: Klaus G
authors: KG
authors: Parhofer
authors: Michael
authors: M
authors: Lehrke
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D058226:Plaque, Atherosclerotic; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D052216:Glucagon-Like Peptide 1
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