title: Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing.
abstract: In the past decade gold nanoparticle-nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid-gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called 'nano-flare' systems. These systems are capable of detecting specific endocellular targets such as mRNAs, microRNAs or small molecules in real time. In this minireview, we discuss the current progress in the field of DNA-nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity.
authors: Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton, SO17 1BJ, UK. A.Kanaras@soton.ac.uk.
authors: Amelie
authors: A
authors: Heuer-Jungemann
authors: Pascal K
authors: PK
authors: Harimech
authors: Tom
authors: T
authors: Brown
authors: Antonios G
authors: AG
authors: Kanaras
mesh_terms: D015374:Biosensing Techniques; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000175:diagnosis; D009693:Nucleic Acid Hybridization
chemical_list: D005456:Fluorescent Dyes; D006046:Gold; D004247:DNA