title: Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed.
abstract: Gallstone disease represents an important issue in the healthcare system. The principal non-invasive non-surgical medical treatment for cholesterol gallstones is still represented by oral litholysis with bile acids. The first successful and documented dissolution of cholesterol gallstones was achieved in 1972. Since then a large number of investigators all over the world, have been dedicated in biochemical and clinical studies on ursodeoxycholic acid (UDCA), demonstrating its extreme versatility. This editorial is aimed to provide a brief review of recent developments in UDCA use, current indications for its use and, the more recent advances in understanding its effects in terms of an anti-inflammatory drug.
authors: Michele Pier Luca
authors: MP
authors: Guarino
authors: Silvia
authors: S
authors: Cocca
authors: Annamaria
authors: A
authors: Altomare
authors: Sara
authors: S
authors: Emerenziani
authors: Michele
authors: M
authors: Cicala
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D042882:Gallstones / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D014580:Ursodeoxycholic Acid
keywords: Cholesterol gallstones; Gallbladder; Ursodeoxycholic acid
references: Dig Dis Sci. 1998 Feb;43(2):349-53
references: 9512129
references: Dig Dis Sci. 2007 May;52(5):1313-25
references: 17390223
references: Eur J Clin Invest. 2002 Jul;32(7):528-34
references: 12153554
references: Dig Dis Sci. 1999 Nov;44(11):2235-43
references: 10573368
references: Hepatology. 1999 Jul;30(1):6-13
references: 10385632
references: Gut. 1996 Sep;39(3):475-8
references: 8949657
references: Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G490-7
references: 11447029
references: Am J Surg. 1993 Apr;165(4):405-9
references: 8480872
references: Gastroenterol Clin North Am. 1999 Mar;28(1):133-44
references: 10198782
references: Hepatology. 2006 Jun;43(6):1276-83
references: 16729326
references: N Engl J Med. 1972 Jan 6;286(1):1-8
references: 5006919
references: Neurogastroenterol Motil. 2002 Dec;14(6):633-42
references: 12464085
references: J Hepatol. 2008;48 Suppl 1:S124-35
references: 18308417
references: Curr Med Chem. 2009;16(12):1531-42
references: 19355905
references: Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G87-94
references: 12065295
references: Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G300-6
references: 11804851
references: Gastroenterology. 1993 Jun;104(6):1865-70
references: 8500748
references: Gut. 2008 Dec;57(12):1740-1
references: 19022933
references: Gastroenterology. 2001 Dec;121(6):1354-71
references: 11729115
references: N Engl J Med. 1989 Mar 9;320(10):633-9
references: 2918875
references: Cell Physiol Biochem. 2007;19(1-4):89-98
references: 17310103
references: Hepatology. 1999 Jun;29(6):1649-54
references: 10347103
references: Liver Int. 2008 Aug;28(7):935-47
references: 18783541
references: World J Gastrointest Pharmacol Ther. 2012 Apr 6;3(2):7-20
references: 22577615
references: Ann Surg. 1989 Nov;210(5):565-75
references: 2684058
references: Am J Surg. 1993 Apr;165(4):399-404
references: 8480871
references: Gastroenterology. 1989 Sep;97(3):726-31
references: 2753332
references: J Gastroenterol Hepatol. 1998 Jun;13(6):659-64
references: 9715413
references: Ann Surg. 2002 Jun;235(6):842-9
references: 12035041
references: NIH Consens Statement. 1992 Sep 14-16;10(3):1-28
references: 1301217
references: BMJ. 1995 Jul 8;311(6997):99-105
references: 7613411
references: World J Gastroenterol. 2007 Oct 7;13(37):5003-8
references: 17854144
references: Gut. 2000 Nov;47(5):728-31
references: 11034593
references: Dig Dis Sci. 1999 Jan;44(1):190-6
references: 9952243
references: Hepatology. 2006 Sep;44(3):650-7
references: 16941683
references: Gastroenterology. 2008 Jun;134(7):2101-10
references: 18442485
references: Gut. 2007 Jun;56(6):815-20
references: 17185355
references: Ann Intern Med. 1982 Sep;97(3):351-6
references: 7051912
references: Clin Sci (Lond). 2011 Dec;121(12):523-44
references: 21854363
references: J Hepatol. 2001 Jul;35(1):134-46
references: 11495032
references: Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G82-8
references: 12936912
references: Eur J Clin Invest. 2013 Apr;43(4):413-26
references: 23419155
references: Dig Dis. 2011;29(1):23-36
references: 21691101