title: Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.
abstract: Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.
authors: Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London, United Kingdom.
authors: Tina
authors: T
authors: Shah
authors: Jorgen
authors: J
authors: Engmann
authors: Caroline
authors: C
authors: Dale
authors: Sonia
authors: S
authors: Shah
authors: Jon
authors: J
authors: White
authors: Claudia
authors: C
authors: Giambartolomei
authors: Stela
authors: S
authors: McLachlan
authors: Delilah
authors: D
authors: Zabaneh
authors: Alana
authors: A
authors: Cavadino
authors: Chris
authors: C
authors: Finan
authors: Andrew
authors: A
authors: Wong
authors: Antoinette
authors: A
authors: Amuzu
authors: Ken
authors: K
authors: Ong
authors: Tom
authors: T
authors: Gaunt
authors: Michael V
authors: MV
authors: Holmes
authors: Helen
authors: H
authors: Warren
authors: Daniel I
authors: DI
authors: Swerdlow
authors: Teri-Louise
authors: TL
authors: Davies
authors: Fotios
authors: F
authors: Drenos
authors: Jackie
authors: J
authors: Cooper
authors: Reecha
authors: R
authors: Sofat
authors: Mark
authors: M
authors: Caulfield
authors: Shah
authors: S
authors: Ebrahim
authors: Debbie A
authors: DA
authors: Lawlor
authors: Philippa J
authors: PJ
authors: Talmud
authors: Steve E
authors: SE
authors: Humphries
authors: Christine
authors: C
authors: Power
authors: Elina
authors: E
authors: Hypponen
authors: Marcus
authors: M
authors: Richards
authors: Rebecca
authors: R
authors: Hardy
authors: Diana
authors: D
authors: Kuh
authors: Nicholas
authors: N
authors: Wareham
authors: Claudia
authors: C
authors: Langenberg
authors: Yoav
authors: Y
authors: Ben-Shlomo
authors: Ian N
authors: IN
authors: Day
authors: Peter
authors: P
authors: Whincup
authors: Richard
authors: R
authors: Morris
authors: Mark W J
authors: MW
authors: Strachan
authors: Jacqueline
authors: J
authors: Price
authors: Meena
authors: M
authors: Kumari
authors: Mika
authors: M
authors: Kivimaki
authors: Vincent
authors: V
authors: Plagnol
authors: Frank
authors: F
authors: Dudbridge
authors: John C
authors: JC
authors: Whittaker
authors: Juan P
authors: JP
authors: Casas
authors: Aroon D
authors: AD
authors: Hingorani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D053858:Metabolic Networks and Pathways / Q000235:genetics; D056186:Metagenomics; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D012107:Research Design; D012307:Risk Factors
chemical_list: D005819:Genetic Markers
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