title: Delta opioid receptor and its peptide: a receptor-ligand neuroprotection.
abstract: In pursuit of neurological therapies, the opioid system, specifically delta opioid receptors and delta opioid peptides, demonstrates promising therapeutic potential for stroke, Parkinson's disease, and other degenerative neurological conditions. Recent studies offer strong evidence in support of the therapeutic use of delta opioid receptors, and provide insights into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies.
authors: Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA. meaghans@mail.usf.edu
authors: Meaghan
authors: M
authors: Staples
authors: Sandra
authors: S
authors: Acosta
authors: Naoki
authors: N
authors: Tajiri
authors: Mibel
authors: M
authors: Pabon
authors: Yuji
authors: Y
authors: Kaneko
authors: Cesar V
authors: CV
authors: Borlongan
mesh_terms: D000818:Animals; D016308:Enkephalin, Leucine-2-Alanine / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D017465:Receptors, Opioid, delta / Q000819:agonists* / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy
chemical_list: D018696:Neuroprotective Agents; D017465:Receptors, Opioid, delta; D016308:Enkephalin, Leucine-2-Alanine
references: Stroke. 1999 Jun;30(6):1271-7; discussion 1278
references: 10356111
references: Life Sci. 1987 Nov 2;41(18):2107-13
references: 2823038
references: Synapse. 2002 Jan;43(1):86-94
references: 11746737
references: Prog Neurobiol. 2010 Apr;90(4):439-70
references: 20036308
references: Brain Res. 1991 May 24;549(2):181-93
references: 1653081
references: J Biol Chem. 2005 Apr 22;280(16):16208-18
references: 15687501
references: Physiol Rev. 1985 Jan;65(1):101-48
references: 3880896
references: Circulation. 1999 Jun 15;99(23):3079-85
references: 10368128
references: Stroke. 2003 May;34(5):1281-6
references: 12677023
references: Cell Mol Life Sci. 2009 Mar;66(6):1105-15
references: 19189047
references: Eur J Pharmacol. 1999 May 21;372(3):R5-7
references: 10395030
references: Neuroscience. 1996 Jun;72(3):785-9
references: 9157323
references: Curr Drug Targets. 2012 Feb;13(2):230-46
references: 22204322
references: J Neurosci. 1997 Sep 15;17(18):7111-8
references: 9278545
references: Brain Res. 2000 Jan 10;852(2):496-500
references: 10678782
references: Pathophysiology. 2007 Dec;14(3-4):183-93
references: 17961999
references: J Neurochem. 2009 Feb;108(3):741-54
references: 19054276
references: Cereb Cortex. 2008 Sep;18(9):2217-27
references: 18203692
references: Vascul Pharmacol. 2005 Apr-May;42(5-6):211-8
references: 15922254
references: Synapse. 2010 Apr;64(4):267-73
references: 19953654
references: J Neurochem. 2003 Aug;86(4):966-79
references: 12887694
references: Neurochem Res. 1996 Nov;21(11):1333-45
references: 8947923
references: Front Biosci. 2004 Sep 01;9:3392-8
references: 15353366
references: J Neurosci. 1997 Jun 1;17(11):4341-8
references: 9151750
references: Brain Res. 2001 Mar 30;896(1-2):56-63
references: 11277973
references: Anesth Analg. 1996 Jun;82(6):1237-41
references: 8638797
references: Eur J Pharmacol. 1999 Feb 5;366(2-3):R7-8
references: 10082218
references: J Exp Biol. 2004 Aug;207(Pt 18):3243-9
references: 15299045
references: J Cell Physiol. 2007 Jul;212(1):60-7
references: 17373650
references: Cell Death Differ. 2007 Dec;14(12):2068-75
references: 17885667
references: Life Sci. 1988;43(19):1565-74
references: 2904105
references: J Pharmacol Exp Ther. 1994 Feb;268(2):683-8
references: 8113979
references: J Pharmacol Exp Ther. 1998 Oct;287(1):322-31
references: 9765353
references: J Neurosci. 1996 Nov 1;16(21):6753-65
references: 8824316
references: Brain Res. 2009 Oct 6;1292:100-6
references: 19619518
references: BMC Biol. 2009 Jun 17;7:31
references: 19534760
references: Brain Res. 2000 Dec 8;885(2):143-53
references: 11102568
references: Science. 1969 Jan 17;163(3864):298-9
references: 5762611
references: Neurobiol Dis. 2001 Aug;8(4):636-46
references: 11493028
references: Science. 1993 May 21;260(5111):1130-2
references: 8493557
references: Neuroreport. 2000 Apr 7;11(5):923-6
references: 10790856
references: Am J Physiol. 1982 Sep;243(3):R281-8
references: 6287869
references: J Cereb Blood Flow Metab. 2007 Feb;27(2):356-68
references: 16773140
references: Anesthesiology. 2004 Mar;100(3):562-8
references: 15108969
references: J Comp Neurol. 2001 Jul 23;436(2):202-10
references: 11438924
references: Science. 1997 Oct 3;278(5335):114-7
references: 9311914
references: Am J Physiol. 1992 Apr;262(4 Pt 2):R595-603
references: 1314516
references: J Neurochem. 2006 Jun;97(5):1494-505
references: 16696856
references: Int Rev Neurobiol. 2007;82:383-95
references: 17678973
references: J Neurosci. 1987 Aug;7(8):2445-64
references: 3039080
references: J Cereb Blood Flow Metab. 1998 Feb;18(2):168-75
references: 9469159
references: Cell Mol Life Sci. 2009 Nov;66(21):3505-16
references: 19756387
references: Life Sci. 1987 Nov 2;41(18):2115-20
references: 2823039
references: Stroke. 2001 Sep;32(9):2170-8
references: 11546913
references: Sheng Li Xue Bao. 2009 Dec 25;61(6):585-92
references: 20029693