title: Influence of the type of vegetable oil on the drug release profile from lipid-core nanocapsules and in vivo genotoxicity study.
abstract: The use of rice bran (RB), soybean (SB) or sunflower seed (SF) oils to prepare lipid-core nanocapsules (LNCs) as controlled drug delivery systems was investigated. LNCs were prepared by interfacial deposition using the preformed polymer method. All formulations showed negative zeta potential and adequate nanotechnological characteristics (particle size 220-230  nm, polydispersity index < 0.20). The environmental safety was evaluated through an in vivo protocol (Allium cepa test) and LNCs containing RB, SB or SF oils did not present genotoxic potential. Clobetasol propionate (CP) was selected as a model drug to evaluate the influence of the type of vegetable oil on the control of the drug release from LNCs. Biphasic drug release profiles were observed for all formulations. After 168  h, the concentration of drug released from the formulation containing SF oil was lower (0.36  mg/mL) than from formulations containing SB (0.40  mg/mL) or RB oil (0.45  mg/mL). Good correlations between the consistency indices for the LNC cores and the burst and sustained drug release rate constants were obtained. Therefore, the type of the vegetal oil was shown as an important factor governing the control of drug release from LNCs.
authors: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria , Santa Maria , Brazil .
authors: Lucas Almeida
authors: LA
authors: Rigo
authors: Viviane
authors: V
authors: Frescura
authors: Luana
authors: L
authors: Fiel
authors: Karine
authors: K
authors: Coradini
authors: Aline Ferreira
authors: AF
authors: Ourique
authors: Tatiana
authors: T
authors: Emanuelli
authors: Andréia
authors: A
authors: Quatrin
authors: Solange
authors: S
authors: Tedesco
authors: Cristiane B da
authors: CB
authors: Silva
authors: Silvia Staniçuaski
authors: SS
authors: Guterres
authors: Adriana Raffin
authors: AR
authors: Pohlmann
authors: Ruy Carlos Ruver
authors: RC
authors: Beck
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002990:Clobetasol / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000633:toxicity; D009152:Mutagenicity Tests; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity; D019697:Onions / Q000187:drug effects / Q000235:genetics; D010938:Plant Oils / Q000737:chemistry* / Q000633:toxicity; D000073879:Rice Bran Oil; D013024:Soybean Oil / Q000737:chemistry* / Q000633:toxicity; D000074242:Sunflower Oil
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D010938:Plant Oils; D000074242:Sunflower Oil; D013024:Soybean Oil; D002990:Clobetasol; D000073879:Rice Bran Oil