title: Optimized Synthesis of Salicylate-based Poly(anhydride-esters).
abstract: The synthesis of a salicylate-based poly(anhydride-ester) was optimized to improve the overall efficiency and quality of the polymer. First, a new approach for the preparation of the polymer precursor minimizes the overall number of synthetic steps and increases the overall yield. Second, the melt-polymerization apparatus was modified to include dynamic mixing, which yields polymer with increased molecular weights on both the milligram and gram scale.
authors: Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8087.
authors: Robert C
authors: RC
authors: Schmeltzer
authors: Theodore J
authors: TJ
authors: Anastasiou
authors: Kathryn E
authors: KE
authors: Uhrich
references: Biomaterials. 1981 Oct;2(4):201-14
references: 7034798
references: Biomaterials. 2000 Dec;21(24):2507-12
references: 11071600
references: Biomaterials. 2000 Oct;21(19):1941-6
references: 10941915
references: Chem Rev. 1999 Nov 10;99(11):3181-98
references: 11749514
references: Nature. 1998 Apr 30;392(6679 Suppl):5-10
references: 9579855
references: Science. 1993 May 14;260(5110):920-6
references: 8493529