title: Association between serum biochemical levels, related to bone metabolism and Parkinson's disease.
abstract: BACKGROUND
  Vitamin D insufficiency and serum calcium disturbance have been reported to be more common in Parkinson's disease (PD) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. Because of the high-vitamin D insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in PD patients in comparison with age-matched healthy controls, for the 1(st) time in a Middle East population.
  
  
  METHODS
  This case-control study was involved 105 (20 were excluded) PD patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin D (25OHD) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods.
  
  
  RESULTS
  There was no significant difference in 25OHD between PD patients and control group (P = 0.071). 25OHD level was not significantly different in PD patients compared to controls {odds ratio 1.003, (confidence interval [CI], 0.98-1.02), P value 0.793}. None of the other biochemical levels did not induce more chance for PD, only we observed in men has more risk of PD than women (odds ratio 2.53, [CI, 1.27-5.03], P value 0.008).
  
  
  CONCLUSIONS
  Our data do not support a possible role of vitamin D insufficiency in PD. Regarding to variable changes in biochemical markers in PD patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of PD.
authors: Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Tehran, Iran ; Department of Medical Sciences, Islamic Azad University, Najaf Abad Branch, Tehran, Iran.
authors: Rokhsareh
authors: R
authors: Meamar
authors: Mohammad
authors: M
authors: Maracy
authors: Ahmad
authors: A
authors: Chitsaz
authors: Mohammad Reza Aghaye
authors: MR
authors: Ghazvini
authors: Maryam
authors: M
authors: Izadi
authors: Amir Pouya
authors: AP
authors: Tanhaei
keywords: 25-hydroxyvitamin D; Bone metabolism; Parkinson's disease; serum calcium
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