title: The neural correlates of mental rotation abilities in cannabis-abusing patients with schizophrenia: an FMRI study.
abstract: Growing evidence suggests that cannabis abuse/dependence is paradoxically associated with better cognition in schizophrenia. Accordingly, we performed a functional magnetic resonance imaging (fMRI) study of visuospatial abilities in 14 schizophrenia patients with cannabis abuse (DD), 14 nonabusing schizophrenia patients (SCZ), and 21 healthy controls (HCs). Participants performed a mental rotation task while being scanned. There were no significant differences in the number of mistakes between schizophrenia groups, and both made more mistakes on the mental rotation task than HC. Relative to HC, SCZ had increased activations in the left thalamus, while DD patients had increased activations in the right supramarginal gyrus. In both cases, hyper-activations are likely to reflect compensatory efforts. In addition, SCZ patients had decreased activations in the left superior parietal gyrus compared to both HC and DD patients. This latter result tentatively suggests that the neurophysiologic processes underlying visuospatial abilities are partially preserved in DD, relative to SCZ patients, consistently with the findings showing that cannabis abuse in schizophrenia is associated with better cognitive functioning. Further fMRI studies are required to examine the neural correlates of other cognitive dysfunctions in schizophrenia patients with and without comorbid cannabis use disorder.
authors: Centre de Recherche de l'Institut Universitaire de Santé Mentale de Montréal, 7331 Hochelaga, Montreal, QC, Canada H1N 3V2 ; Department of Psychiatry, Faculty of Medicine, University of Montreal, 2900 Edouard-Montpetit, Montreal, QC, Canada H3C 3J7.
authors: Stéphane
authors: S
authors: Potvin
authors: Josiane
authors: J
authors: Bourque
authors: Myriam
authors: M
authors: Durand
authors: Olivier
authors: O
authors: Lipp
authors: Pierre
authors: P
authors: Lalonde
authors: Emmanuel
authors: E
authors: Stip
authors: Sylvain
authors: S
authors: Grignon
authors: Adrianna
authors: A
authors: Mendrek
references: PLoS One. 2013;8(2):e55821
references: 23390554
references: J Neuroimaging. 2011 Jan;21(1):16-23
references: 19659683
references: Neuroimage. 2007 Jul 15;36(4):1374-86
references: 17532647
references: J Neurosci. 2012 Jan 4;32(1):12-20
references: 22219266
references: Schizophr Res. 2003 Oct 1;63(3):297-9
references: 12957709
references: Am J Psychiatry. 2008 Apr;165(4):490-6
references: 18281413
references: Neuroimage. 2002 Nov;17(3):1623-33
references: 12414300
references: Brain. 2006 May;129(Pt 5):1096-112
references: 16585053
references: Schizophr Res. 2009 Mar;108(1-3):293-4
references: 19150221
references: Curr Drug Abuse Rev. 2008 Jan;1(1):81-98
references: 19630708
references: Schizophr Res. 2004 Dec 15;72(1):29-39
references: 15531405
references: Biol Psychiatry. 2005 Mar 15;57(6):594-608
references: 15780846
references: Schizophr Res. 2011 May;128(1-3):111-6
references: 21420282
references: Neuropsychologia. 2010 Jan;48(2):529-35
references: 19850055
references: J Cereb Blood Flow Metab. 1995 May;15(3):361-70
references: 7713993
references: Neuropsychologia. 2002;40(7):917-30
references: 11900744
references: Curr Top Behav Neurosci. 2010;4:373-90
references: 21312407
references: Psychiatry Res. 2011 Dec 30;194(3):245-256
references: 22079660
references: Psychiatry Res. 2010 Jan 30;181(1):51-6
references: 19962862
references: Lancet. 2007 Jul 28;370(9584):319-28
references: 17662880
references: Psychiatry Res. 2006 Feb 28;141(2):129-39
references: 16427141
references: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):1-10
references: 18727949
references: Biol Psychiatry. 2011 Dec 15;70(12):1134-42
references: 21861988
references: Psychopharmacology (Berl). 2006 Nov;188(4):425-44
references: 17019571
references: Front Hum Neurosci. 2009 Nov 24;3:53
references: 19956405
references: J Clin Psychiatry. 2003 Jun;64(6):663-7
references: 12823080
references: Am J Psychiatry. 1996 Mar;153(3):321-30
references: 8610818
references: Med Sci Sports Exerc. 2011 Oct;43(10):1857-62
references: 21407123
references: Schizophr Res. 2010 Jul;120(1-3):95-100
references: 20483565
references: Neuroimage. 2002 Jan;15(1):273-89
references: 11771995
references: Curr Pharm Des. 2012;18(32):5055-69
references: 22716150
references: Encephale. 2003 Jan-Feb;29(1):11-7
references: 12640322
references: Psychopharmacology (Berl). 2004 Nov;176(3-4):239-47
references: 15205869
references: Neuroimage. 2002 Mar;15(3):547-58
references: 11848697
references: Neuropsychology. 2009 May;23(3):315-36
references: 19413446
references: Schizophr Res. 2001 Mar 1;48(1):69-82
references: 11278155
references: Schizophr Res. 2008 Mar;100(1-3):242-51
references: 17614260
references: JAMA. 1990 Nov 21;264(19):2511-8
references: 2232018
references: Clin Immunol. 2012 Jan;142(1):57-67
references: 21420365
references: Neuropsychol Rev. 2013 Jun;23(2):117-37
references: 23129391
references: Neuroimage. 2003 Sep;20(1):225-32
references: 14527583
references: Schizophr Res. 2004 Apr 1;67(2-3):305-7
references: 14984893
references: Schizophr Bull. 1987;13(2):261-76
references: 3616518
references: Br J Psychiatry. 2008 Nov;193(5):357-63
references: 18978312
references: Neuroimage. 2006 Aug 1;32(1):432-44
references: 16650777
references: Arch Gen Psychiatry. 1992 Aug;49(8):624-9
references: 1637252
references: Neuroimage. 2006 Aug 1;32(1):445-56
references: 16714123
references: Schizophr Res. 2012 Aug;139(1-3):13-8
references: 22633527
references: Brain Cogn. 2005 Oct;59(1):38-42
references: 15913868
references: Encephale. 2006 May-Jun;32(3 Pt 1):341-50
references: 16840928
references: Psychol Med. 2013 Oct;43(10):2047-56
references: 23237024
references: Conscious Cogn. 2006 Jun;15(2):295-309
references: 16182569
references: Acta Neuropathol. 2009 Apr;117(4):347-68
references: 18604544
references: Schizophr Res. 2008 Feb;99(1-3):1-6
references: 18248793
references: Nat Rev Neurosci. 2003 Nov;4(11):873-84
references: 14595399
references: Psychol Med. 2010 Mar;40(3):383-98
references: 19627647
references: Behav Brain Res. 2009 Sep 14;202(2):153-61
references: 19463696
references: Science. 1971 Feb 19;171(3972):701-3
references: 5540314
references: Brain. 1996 Feb;119 ( Pt 1):89-100
references: 8624697
references: J Cogn Neurosci. 2012 Mar;24(3):588-99
references: 22066583
references: Neuroimage. 2007 Apr 15;35(3):1264-77
references: 17346989
references: Cogn Neuropsychiatry. 2013;18(6):615-30
references: 23343453
references: Neuropsychopharmacology. 2004 Aug;29(8):1558-72
references: 15173844
references: Aust N Z J Psychiatry. 2007 Oct;41(10):792-9
references: 17828652
references: Curr Top Behav Neurosci. 2010;4:509-28
references: 21312411
references: J Int Neuropsychol Soc. 2003 Jul;9(5):679-89
references: 12901774
references: Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1054-63
references: 17482741
references: Am J Psychiatry. 2010 Aug;167(8):987-93
references: 20478874
references: Neuroimage. 2004 Dec;23(4):1440-9
references: 15589108
references: Schizophr Bull. 2012 Mar;38(2):316-30
references: 20660494
references: Cogn Neuropsychiatry. 2010 Jul;15(4):397-405
references: 20094930
references: Schizophr Bull. 2000;26(1):179-92
references: 10755680
references: Psychopharmacology (Berl). 2009 Jul;205(1):45-52
references: 19326102
references: Schizophr Res. 2010 Sep;122(1-3):53-62
references: 20385471
references: J Addict Med. 2011 Mar;5(1):1-8
references: 21321675
references: Schizophr Bull. 2010 Nov;36(6):1115-30
references: 19386576
references: Brain. 2000 Jan;123 ( Pt 1):65-73
references: 10611121
references: Schizophr Res. 2007 Nov;96(1-3):169-84
references: 17826035
references: Curr Psychiatry Rep. 2001 Dec;3(6):507-12
references: 11707165
references: Front Psychiatry. 2012 Oct 30;3:94
references: 23115554
references: Arch Gen Psychiatry. 2009 Apr;66(4):442-51
references: 19349314
references: Neuroimage. 2001 Jan;13(1):143-52
references: 11133317
references: Int J Neuropsychopharmacol. 2012 Apr;15(3):297-307
references: 21557880
references: Schizophr Res. 2005 Jun 1;75(1):135-7
references: 15820332