title: [Pathological mechanisms in rheumatoid arthritis].
abstract: Rheumatoid arthritis(RA) is a representative autoimmune disease characterized by systemic, chronic, destructive inflammatory synovitis and multiple organ manifestations, resulting in severe disability and mortality rates. Immune cells such as T cells, B cells, dendritic cells and macrophages and cellular interaction among them through cytokines and cell surface molecules plays a pivotal role in the pathological processes of RA. The accumulation of inflammatory cells, the self-perpetuation of inflammation and induction and/or activation of osteoclasts lead to cartilage and bone destruction and multiple organ manifestations. The importance of immune systems in the pathogenesis of RA has become apparent based on the clinical efficacy of biologic agents TNF, IL-6, CD28 and CD20. The research translation between bench and bedside would bring enormous progress in the treatment of RA.
authors: First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
authors: Yoshiya
authors: Y
authors: Tanaka
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology / Q000473:pathology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D001847:Bone Diseases / Q000209:etiology / Q000473:pathology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
chemical_list: D016207:Cytokines