title: GSTP1 Ile105Val polymorphism and prostate cancer risk: evidence from a meta-analysis.
abstract: BACKGROUND
  Glutathione S-transferase P1 (GSTP1) is thought to be involved in the detoxification of reactive carcinogen metabolites. Numerous epidemiological studies have evaluated the association of GSTP1 Ile105Val polymorphism with the risk of prostate cancer. However, the results remain inconclusive. To derive a more precise estimation, a meta-analysis was performed.
  
  
  RESULTS
  A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the relationship. The overall association was not significant (Val/Val vs. Ile/Ile OR = 1.06, 95% CI = 0.90-1.25, P = 0.50; Val/Val vs. Val/Ile+Ile/Ile: OR = 1.07, 95% CI = 0.91-1.25, P = 0.44). In subgroup analyses by ethnicity and prostate cancer grade, the similar results were observed. However, in stratified analysis by clinical stage, we found a significant association with low-stage prostate cancer (Val/Val vs. Ile/Ile: OR = 2.70, 95% CI = 1.73-4.22, P<0.001; Val/Val vs. Val/Ile+Ile/Ile: OR = 2.14, 95% CI = 1.38-3.33, P = 0.001). Moreover, there was no statistically significant evidence of multiplicative interactions neither between the GSTP1 Ile105Val polymorphism and GSTM1, nor between smoking status and GSTP1 on prostate cancer risk.
  
  
  CONCLUSIONS
  This meta-analysis showed that GSTP1 Ile105Val polymorphism might not be significantly associated with overall prostate cancer risk. Further stratified analyses showed a significant association with low-stage prostate cancer.
authors: Department of Urology, Affiliated Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors: Bingbing
authors: B
authors: Wei
authors: You
authors: Y
authors: Zhou
authors: Zhuoqun
authors: Z
authors: Xu
authors: Jun
authors: J
authors: Ruan
authors: Huan
authors: H
authors: Cheng
authors: Ming
authors: M
authors: Zhu
authors: Qiang
authors: Q
authors: Hu
authors: Ke
authors: K
authors: Jin
authors: Zhiqiang
authors: Z
authors: Yan
authors: Deqi
authors: D
authors: Zhou
authors: Feng
authors: F
authors: Xuan
authors: Hongyi
authors: H
authors: Zhou
authors: Zhirong
authors: Z
authors: Wang
authors: Xing
authors: X
authors: Huang
authors: Qiang
authors: Q
authors: Wang
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000235:genetics
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C496556:GSTP1 protein, human
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