title: Familial orthostatic tremor and essential tremor in two young brothers: A rare entity.
abstract: Orthostatic tremor (OT), is usually a disease of old age and is characterized by quivering movements of the legs during quiet standing or in the state of isometric contraction in the lower limbs. This is relieved on walking or on lying down. It is diagnosed by surface electromyography, particularly over the quadriceps femoris muscles which shows a distinctive frequency of 13 to 18 Hz on standing. Some investigators consider it as a variant of essential tremor (ET) and the two conditions often co-exist. The disease is usually non-familial. Two brothers presented with tremor in the lower limbs on standing and on the outstretched hands without any family history. Subsequently, they were proved to be suffering from OT and ET by clinical examination and surface EMG. Simultaneous occurrence of OT and ET in two young brothers without any family history in the previous generation has not been described before and they also appeared at a much earlier age than what is described in the literature.
authors: Department of Neuromedicine, RG Kar Medical College and Hospital, Kolkata, West Bengal, India.
authors: Kalyan B
authors: KB
authors: Bhattacharyya
authors: D
authors: D
authors: Das
keywords: Essential tremor; familial; orthostatic tremor; young age
references: Arch Neurol. 1995 Mar;52(3):299-305
references: 7872885
references: Mov Disord. 2003 Feb;18(2):195-9
references: 12539215
references: Arch Neurol. 1984 Aug;41(8):880-1
references: 6466163
references: Mov Disord. 1998;13 Suppl 3:2-23
references: 9827589
references: Mov Disord. 2004 Jul;19(7):788-795
references: 15254936
references: Mov Disord. 2005 Nov;20(11):1455-61
references: 16037915
references: Neurology. 1986 Sep;36(9):1241-5
references: 3748391
references: Ann Neurol. 1993 Jul;34(1):82-90
references: 8517685
references: Arch Neurol. 1986 Jun;43(6):584-7
references: 3718286
references: Riv Sper Freniatr Med Leg Alien Ment. 1970 Apr 30;94(2):450-7
references: 4320856
references: Neurology. 2012 Jul 17;79(3):288-9
references: 22764256
references: Neurology. 2006 May 23;66(10):1600-1
references: 16717234