title: Synthesis of dihydrobenzofurans with quaternary carbon center under mild and neutral conditions.
abstract: A new method has been developed for the construction of dihydrobenzofurans from O-aryloxime ethers bearing an α-cyano group using a sequential regioselective isomerization/[3,3]-sigmatropic rearrangement/cyclization reaction in MeOH without any catalysts under neutral conditions at ambient temperature. The current transformation provides environmentally benign and atom-economical access to a variety of dihydrobenzofurans containing a quaternary carbon from readily available cyclic and acyclic oxime ethers.
authors: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors: Norihiko
authors: N
authors: Takeda
authors: Masafumi
authors: M
authors: Ueda
authors: Syunsuke
authors: S
authors: Kagehira
authors: Hiroyuki
authors: H
authors: Komei
authors: Norimitsu
authors: N
authors: Tohnai
authors: Mikiji
authors: M
authors: Miyata
authors: Takeaki
authors: T
authors: Naito
authors: Okiko
authors: O
authors: Miyata
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry; D010091:Oximes / Q000737:chemistry
chemical_list: D001572:Benzofurans; D004987:Ethers; D009570:Nitriles; D010091:Oximes