title: Stability of tubocurarine chloride injection at ambient temperature and 4 deg C in polypropylene syringes.
abstract: The stabililty of 3 mg/mL tubocurarine chloride injection in 3-mL polypropylene syringes stored at ambient temperature and at 4 deg C for up to 90 days was investigated. A high-performance liquid chromatographic stability-indicating assay was used to determine concentration levels of tubocurarine chloride injection 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Benzyl alcohol, which was used as a preservative, did not interfere wiht the assay. At 25 deg C, the loss in potency was less than 10% after the syringes had been stored for 45 days; at 4 deg C, that loss was less than 1% after 90 days of storage. The pH of tubocurarine chloride injection did not change appreciably during the 90-day study period.
authors: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.
authors: James T
authors: JT
authors: Stewart
authors: Meredith L
authors: ML
authors: Storms
authors: Flynn W
authors: FW
authors: Warren