title: Leptin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage.
abstract: Leptin has been identified as a plasma marker for outcomes in traumatic brain injury and intracerebral hemorrhage. We further investigated whether leptin might serve as a marker for severity and prognosis in aneurysmal subarachnoid hemorrhage. One hundred and eight consecutive patients and 108 sex and age - matched healthy subjects were recruited. Plasma leptin levels were measured by enzyme-linked immunosorbent assay. Clinical severity was assessed using World Federation of Neurological Surgeons score and Fisher score. Mortality and poor long-term outcome (Glasgow outcome scale scores of 1-3) at 6 months were recorded. Plasma leptin levels on admission were substantially higher in patients than in healthy controls, and were significantly associated with the clinical severity. There was also a significant association between leptin levels and clinical outcomes at 6 months in multivariate logistic regression analysis. Using receiver operating characteristic curves, we calculated areas under the curve for clinical outcomes at 6 months. The predictive performance of leptin was similar to, but did not obviously improve those of World Federation of Neurological Surgeons score and Fisher score. Thus, leptin may indicate clinical severity of the initial bleeding and also have prognostic value for clinical outcomes in aneurysmal subarachnoid hemorrhage and may therefore help in guiding treatment decisions in the setting of aneurysmal subarachnoid hemorrhage.
authors: Department of Neurosurgery, Quzhou People's Hospital, 2 Zhongloudi Road, Kecheng District, Quzhou 324000, China.
authors: Xiao-Feng
authors: XF
authors: Fan
authors: Zhen-Hong
authors: ZH
authors: Chen
authors: Qiang
authors: Q
authors: Huang
authors: Wei-Min
authors: WM
authors: Dai
authors: Yuan-Qing
authors: YQ
authors: Jie
authors: Guo-Feng
authors: GF
authors: Yu
authors: An
authors: A
authors: Wu
authors: Xin-Jiang
authors: XJ
authors: Yan
authors: Yun-Ping
authors: YP
authors: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001930:Brain Injuries / Q000097:blood* / Q000473:pathology; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D020738:Leptin
keywords: Aneurysmal subarachnoid hemorrhage; Functional outcome; Leptin; Mortality