title: Neonatal opiate withdrawal and rooming-in: a retrospective analysis of a single center experience.
abstract: OBJECTIVE
  To evaluate our treatment of neonatal abstinence syndrome (NAS), our experience with rooming-in of opiate-dependent mothers and to examine the influence of rooming-in on short term outcome of infants exposed to opiates in utero.
  
  
  METHODS
  Retrospective analysis of maternal and perinatal data of newborn infants with NAS treated between 2004 and 2011 in a level 3 academic children's hospital in a German metropolis. Therapy of NAS and duration of therapy, length of hospital stay and costs were considered in particular.
  
  
  RESULTS
  Data of 77 newborns with NAS were analysed. 84.6% of infants were treated with tincture of opium (79.2% rooming-in, 88.7% no rooming-in). Infants with rooming-in (n=24) had a 17% shorter median duration of therapy [27.0 d (IQR 24.0-38.5), no rooming-in (n=53) 32.5 d (IQR 25.0-54.5)] and shorter median length of hospital stay [33.0 d (IQR 28.0-48.0), no rooming-in 41.5 d (IQR 30.3-54.5)]. Demographic data was comparable between newborns and mothers with or without rooming-in. Costs were median 13 457 € (IQR 8 967-17 494)/patient [rooming-in: 9 547 € (IQR 7 024-16 135), no rooming-in: 14 486 € (IQR 9 479-19 352)].
  
  
  CONCLUSIONS
  Rooming-in in NAS should be encouraged to shorten duration of therapy and length of hospital stay and thereby reduce costs. No major problems arose in the care of the infants with NAS when parents stayed with their infants but close monitoring of the newborn and strict instruction of parents are required.
authors: Neonatology, Children's Hospital of the University of Cologne, Germany.
authors: C
authors: C
authors: Hünseler
authors: M
authors: M
authors: Brückle
authors: B
authors: B
authors: Roth
authors: A
authors: A
authors: Kribs
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005858:Germany; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D009357:Neonatal Abstinence Syndrome / Q000175:diagnosis / Q000534:rehabilitation*; D009293:Opioid-Related Disorders / Q000175:diagnosis / Q000534:rehabilitation*; D009892:Opium / Q000008:administration & dosage*; D018743:Perinatal Care; D012189:Retrospective Studies; D012386:Rooming-in Care; D016896:Treatment Outcome
chemical_list: D009892:Opium