title: Chromosome 19p in Alzheimer's disease: when genome meets transcriptome.
abstract: Genetic studies have identified several genomic loci including chr19p13.2 relevant to Alzheimer's disease (AD) susceptibility. However, the functional roles of these genomic loci in AD pathogenesis require further clarification. Transcriptome as an endophenotype is critical for the understanding of disease mechanism. Here we demonstrate that chr19p is the most significantly perturbed chromosome region in AD brain transcriptome. With dual evidence from genome and transcriptome, chr19p likely play a special role in AD pathogenesis.
authors: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China.
authors: Jiajia
authors: J
authors: Wang
authors: Xuemei
authors: X
authors: Feng
authors: Zhouxian
authors: Z
authors: Bai
authors: Lee-Way
authors: LW
authors: Jin
authors: Yong
authors: Y
authors: Duan
authors: Hongxing
authors: H
authors: Lei
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000378:metabolism; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D062126:Databases, Chemical / Q000706:statistics & numerical data; D015870:Gene Expression; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D046228:Microarray Analysis; D059467:Transcriptome / Q000235:genetics*
keywords: Chromosome 19p; KANK2; complement C3; gene expression; genetic association