title: Excessive Hepatic Arterial-portal Venous Shunting May Predict Failure of Microparticle Localization in Hepatocellular Carcinomas.
abstract: Locoregional treatment of hepatocellular carcinomas using yttrium-90 (Y-90) microspheres is an emerging modality, and involves the administration of such radioactive particles directly into the hepatic arterial vasculature. We present the case of a 58-year-old gentleman undergoing evaluation for Y-90 microsphere therapy for hepatocellular carcinoma, in which our findings suggest that significant hepatic arterial portal venous shunting detected during the angiogram maybe a predictor of poor localization of microspheres in the turmor, and that centers that utilize body surface area (BSA) approaches for dosimetry should take note of such findings.
authors: Department of Nuclear Medicine and PET, Singapore General Hospital, Outram, Singapore.
authors: Andrew Eik Hock
authors: AE
authors: Tan
authors: Yung Hsiang
authors: YH
authors: Kao
authors: Wanying
authors: W
authors: Xie
keywords: Hepatocellular carcinoma; Y-90 microsphere therapy; arteria-portal venous shunting
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