title: Study of thrombocytopenia in patients of malaria.
abstract: BACKGROUND
  Malaria is a Protozoal disease caused by infection with parasites of the genus Plasmodium and transmitted to man by certain species of infected female Anopheline mosquito. In 2008 there were 1.52 million cases of malaria in India, out of which 0.76 million case of Plasmodium falciparum, comprising 50% of total malaria cases. There were 924 deaths from malaria. Hematological abnormalities have been observed in patients with malaria, with anemia, and thrombocytopenia being the most common.
  
  
  METHODS
  We conducted this study to find out the frequency and the degree of thrombocytopenia in patients with malaria. In our study, 230 patients with malaria positive were investigated with platelet count.
  
  
  RESULTS
  In the study group of 230 patients: 130 (56.51%) were positive for Plasmodium vivax, 90 (39.13%) were positive for P. falciparum and 10 (4.34%) had mixed infection with both P. vivax and P. falciparum. Out of 130 cases detected with vivax malaria, 100 cases had thrombocytopenia. Out of 90 cases detected with falciparum malaria, 70 cases had thrombocytopenia. Among 10 cases of mixed infection, 9 cases had thrombocytopenia.
  
  
  CONCLUSIONS
  Presence of thrombocytopenia in a patient with acute febrile illness in the tropics increases the possibility of malaria. The above finding can have therapeutic implications in context of avoiding unnecessary platelet infusion in malaria patients.
authors: Department of Pathology, ESIC Model Hospital Cum Occupational Disease Centre, Indore, Madhya Pradesh, India.
authors: Narendra Kumar
authors: NK
authors: Gupta
authors: Shyam Babu
authors: SB
authors: Bansal
authors: Uttam Chand
authors: UC
authors: Jain
authors: Kiran
authors: K
authors: Sahare
keywords: Malaria; Plasmodium falciparum; Plasmodium vivax; thrombocytopenia
references: Acta Trop. 2011 Feb;117(2):82-5
references: 20943199
references: Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):277-99
references: 10942626
references: Saudi Med J. 2001 Feb;22(2):133-8
references: 11299407
references: Southeast Asian J Trop Med Public Health. 2010 Sep;41(5):1035-41
references: 21073022
references: Aust N Z J Med. 1992 Apr;22(2):169-70
references: 1530541
references: Malar J. 2010 Dec 13;9 Suppl 3:S4
references: 21144084
references: J Assoc Physicians India. 2004 Aug;52:615-8
references: 15847353
references: Indian J Pathol Microbiol. 2006 Oct;49(4):505-8
references: 17183838
references: Platelets. 2010;21(4):307-9
references: 20178400
references: J Trop Pediatr. 2005 Apr;51(2):120-1
references: 15843368
references: J Trop Pediatr. 2007 Jun;53(3):210-2
references: 17264156
references: Diagn Microbiol Infect Dis. 1999 Nov;35(3):243-4
references: 10626136
references: Indian J Pediatr. 2009 May;76(5):551-2
references: 19390798
references: Braz J Infect Dis. 2002 Oct;6(5):263-5
references: 12495609
references: Invest Clin. 2009 Jun;50(2):187-201
references: 19662814
references: J Vector Borne Dis. 2007 Dec;44(4):266-71
references: 18092534
references: Indian J Med Sci. 2004 Jun;58(6):239-44
references: 15226575
references: Iran J Parasitol. 2010 Sep;5(3):69-70
references: 22347258
references: Travel Med Infect Dis. 2009 Mar;7(2):111-7
references: 19237144
references: J Trop Pediatr. 2006 Feb;52(1):49-51
references: 15980019
references: Platelets. 2010;21(8):623-7
references: 21050055