title: Corticosteroid responsive prolonged thrombocytopenia in a case of dengue fever.
abstract: Thrombocytopenia and bleeding manifestations are consistent features of dengue fever. Usually thrombocytopenia resolves and platelet count normalises by day 10 of fever. Persistent thrombocytopenia is not a feature of dengue fever. Proposed mechanisms behind thrombocytopenia are many. Direct platelet destruction by dengue virus, immune-mediated platelet destruction and even megakaryocytic immune injury have been proposed as underlying mechanisms. We are reporting a case of an old man who presented in dengue season in 2012 with fever and bleeding and was diagnosed as a case of dengue fever. He developed persistent thrombocytopenia requiring treatment on the lines of immune thrombocytopenia and responded to steroids. Other causes of thrombocytopenia were ruled out.
authors: Division of Clinical Haematology, Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research JIPMER, Pondicherry, India. drspkgmu@rediffmail.com
authors: Shailendra Prasad
authors: SP
authors: Verma
authors: Abdoul
authors: A
authors: Hamide
authors: Jyoti
authors: J
authors: Wadhwa
authors: Kalaimani
authors: K
authors: Sivamani
mesh_terms: D000368:Aged; D003715:Dengue / Q000150:complications / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone
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