title: Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.
abstract: The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-d/l-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics.
authors: Institute of Biomolecule Reconstruction (iBR), Department of Pharmaceutical Engineering, Sun Moon University, Tangjeong-myeon, Asan-si, Chungnam, Republic of Korea.
authors: Ramesh Prasad
authors: RP
authors: Pandey
authors: Prakash
authors: P
authors: Parajuli
authors: Niranjan
authors: N
authors: Koirala
authors: Je Won
authors: JW
authors: Park
authors: Jae Kyung
authors: JK
authors: Sohng
mesh_terms: D001407:Bacillus / Q000201:enzymology; D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery / Q000379:methods*; D004926:Escherichia coli; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism*; D060847:Metabolic Engineering / Q000379:methods*; D015394:Molecular Structure; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism
chemical_list: D005419:Flavonoids; D009702:Nucleoside Diphosphate Sugars; D016695:Glycosyltransferases; C041477:3-hydroxyflavone
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