title: Steroidal saponins from the flowers of Dioscorea bulbifera var. sativa.
abstract: Eleven steroidal saponins, dioscoreanosides A-K, along with five known congeners, were isolated from the flowers of Dioscorea bulbifera var. sativa. Their structures were established by extensive NMR experiments in conjunction with mass spectrometry. The isolated compounds were tested for cytotoxicity against urinary bladder carcinoma cells (ECV-304 cells). Our results revealed a moderate activity for spiroconazol A (15), pennogenin 3-O-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (12), and 26-O-ß-d-glucopyranosyl-(25R)-5-en-furost-3ß,17α,22α,26-tetraol-3-O-α-l-rhamnopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→4)-[α-l-rhamnopyranosyl-(1→2)]-β-d-glucopyranoside (13).
authors: Department of Chemistry, Faculty of Science, University of Dschang, Box 183, Dschang, Cameroon; Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Königin-Luise-Str. 2-4, D-14195 Berlin, Germany. Electronic address: Tapondjou2001@yahoo.fr.
authors: Léon Azefack
authors: LA
authors: Tapondjou
authors: Kristina
authors: K
authors: Jenett-Siems
authors: Stefan
authors: S
authors: Böttger
authors: Matthias F
authors: MF
authors: Melzig
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D027742:Dioscorea / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: C588391:26-O-glucopyranosyl-5-en-furost-3,17,22,26-tetraol-3-O-rhamnopyranosyl-(1-4)-rhamnopyranosyl-(1-4)-(rhamnopyranosyl-(1-2))glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D010840:Phytosterols; D010936:Plant Extracts; D012503:Saponins; C588390:pennogenin 3-O-rhamnopyranosyl-(1-4)-rhamnopyranosyl-(1-4)-(rhamnopyranosyl-(1-2))glucopyranoside; C588392:spiroconazol A
keywords: Cytotoxicity; Dioscorea bulbifera var. sativa; Dioscoreaceae; Pennogenin; Steroidal saponins