title: T cell recognition of beryllium.
abstract: Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by a hypersensitivity to beryllium and characterized by the accumulation of beryllium-specific CD4(+) T cells in the lung. Genetic susceptibility to beryllium-induced disease is strongly associated with HLA-DP alleles possessing a glutamic acid at the 69th position of the β-chain (βGlu69). The structure of HLA-DP2, the most prevalent βGlu69-containing molecule, revealed a unique solvent-exposed acidic pocket that includes βGlu69 and represents the putative beryllium-binding site. The delineation of mimotopes and endogenous self-peptides that complete the αβTCR ligand for beryllium-specific CD4(+) T cells suggests a unique role of these peptides in metal ion coordination and the generation of altered self-peptides, blurring the distinction between hypersensitivity and autoimmunity.
authors: Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
authors: Shaodong
authors: S
authors: Dai
authors: Michael T
authors: MT
authors: Falta
authors: Natalie A
authors: NA
authors: Bowerman
authors: Amy S
authors: AS
authors: McKee
authors: Andrew P
authors: AP
authors: Fontenot
mesh_terms: D001607:Berylliosis / Q000235:genetics / Q000276:immunology*; D001608:Beryllium / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D020022:Genetic Predisposition to Disease; D006801:Humans
chemical_list: D001608:Beryllium
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