title: An association study between the norepinephrine transporter gene and depression.
abstract: A potential approach for identification of candidate genes for depression is characterization of chromosomal rearrangements. Through analysis of a chromosome translocation in an individual with recurrent depression, we identified a potential candidate gene: the norepinephrine transporter (NET; SLC6A2 for solute carrier 6 family member 2). The gene is responsible for the reuptake of norepinephrine and dopamine into presynaptic nerve terminals and the norepinephrine system appears to play an important role in depression. We therefore analyzed genetic variants within SLC6A2 for association with depression in 408 affected and 559 control individuals from Denmark. After quality control of the genotypes, 31 of 45 single nucleotide polymorphisms (SNPs) were left for analyses. One SNP showed a nominal association with depression but did not survive correction for multiple testing. The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
authors: Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark. henrbutt@rm.dk
authors: Henriette N
authors: HN
authors: Buttenschøn
authors: Iben S
authors: IS
authors: Jacobsen
authors: Matias B
authors: MB
authors: Grynderup
authors: Ase M
authors: AM
authors: Hansen
authors: Henrik A
authors: HA
authors: Kolstad
authors: Linda
authors: L
authors: Kaerlev
authors: Jane F
authors: JF
authors: Thomsen
authors: Merete
authors: M
authors: Nordentoft
authors: Asli
authors: A
authors: Silahtaroglu
authors: Niels
authors: N
authors: Tommerup
authors: Zeynep
authors: Z
authors: Tümer
authors: Jesper
authors: J
authors: Krogh
authors: Anders D
authors: AD
authors: Børglum
authors: Ole
authors: O
authors: Mors
mesh_terms: D000328:Adult; D019457:Chromosome Breakage; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D003863:Depression / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human