title: Gold-catalyzed hydration of haloalkynes to α-halomethyl ketones.
abstract: A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through hydration of a wide range of haloalkynes. Other outstanding features include excellent yields from both alkyl- and aryl-substituted haloalkynes and wide functional group tolerance. This protocol is an alternative to conventional α-halogenation of ketones.
authors: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, People's Republic of China.
authors: Longyong
authors: L
authors: Xie
authors: Yundong
authors: Y
authors: Wu
authors: Weiguo
authors: W
authors: Yi
authors: Lei
authors: L
authors: Zhu
authors: Jiannan
authors: J
authors: Xiang
authors: Weimin
authors: W
authors: He
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D007659:Ketones; D050607:Organogold Compounds; D014867:Water