title: Anti-inflammatory and anti-nociceptive activities of two new triterpenoids from Adiantum capillus-veneris Linn.
abstract: Two new triterpenoids characterised as 30-normethyl fernen-22-one (capillirone, 1) and hopan-3β-ol (capillirol B, 2), along with two known triterpenoids, 4-α-hydroxyfilican-3-one and 3-β,4-α-dihydroxyfilicane, have been isolated from the ethanolic extract of the fronds of Adiantum capillus-veneris Linn. (Adiantaceae). Compounds 1 and 3 showed significant anti-inflammatory activity with 33.07% (p < 0.01) and 42.30% (p < 0.001) inhibition as compared to indomethacin that exhibited 60.00% (p < 0.001) inhibition after 3 h in the carrageenan-induced hind paw oedema method. Compound 3 showed potent anti-nociceptive activity with 42.37% inhibition as compared to indomethacin that showed 45.34% inhibition in the writhing test.
authors: a Department of Chemistry , Faculty of Science, Jamia Hamdard (Hamdard University) , New Delhi , 110062 , India.
authors: Saqlain
authors: S
authors: Haider
authors: Chetna
authors: C
authors: Kharbanda
authors: Mohammad Sarwar
authors: MS
authors: Alam
authors: Hinna
authors: H
authors: Hamid
authors: Mohammad
authors: M
authors: Ali
authors: Mahboob
authors: M
authors: Alam
authors: Syed
authors: S
authors: Nazreen
authors: Yakub
authors: Y
authors: Ali
mesh_terms: D035681:Adiantum / Q000737:chemistry*; D000700:Analgesics / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes; D002351:Carrageenan