title: Epigenetics of human papillomaviruses.
abstract: Human papilllomaviruses (HPVs) are common human pathogens that infect cutaneous or mucosal epithelia in which they cause warts, self-contained benign lesions that commonly regress. The HPV life cycle is intricately tied to the differentiation of the host epithelium it infects. Mucosotropic HPVs are the most common sexually transmitted pathogen known to mankind. A subset of the mucosotropic HPVs, so-called high risk HPVs, is etiologically associated with numerous cancers of the anogenital tract, most notably the cervix, as well as a growing fraction of head and neck cancers. In these cancers, the HPV genome, which normally exists an a double stranded, circular, nuclear plasmid, is commonly found integrated into the host genome and expresses two viral oncogenes, E6 and E7, that are implicated in the development and maintainance of the cancers caused by these high risk HPVs. Numerous studies, primarily on the high risk HPV16, have documented that the methylation status of the viral genome changes not only in the context of the viral life cycle but also in the context of the progressive neoplastic disease that culminates in cancer. In this article, we summarize the knowledge gained from those studies. We also provide the first analysis of available ChIP-seq data on the occupancy of both epigentically modified histones as well as transcription factors on the high risk HPV18 genome in the context of HeLa cells, a cervical cancer-derived cell line that has been the subject of extensive analyses using this technique.
authors: Department of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA; McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
authors: Eric
authors: E
authors: Johannsen
authors: Paul F
authors: PF
authors: Lambert
mesh_terms: D001483:Base Sequence; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D004279:DNA, Viral / Q000235:genetics; D018450:Disease Progression; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005260:Female; D016679:Genome, Viral; D006367:HeLa Cells; D006657:Histones / Q000378:metabolism; D052161:Human papillomavirus 18 / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D030361:Papillomavirus Infections / Q000473:pathology; D011485:Protein Binding; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology; D014779:Virus Replication
chemical_list: D002843:Chromatin; D004279:DNA, Viral; D006657:Histones; D009856:Oncogene Proteins, Viral; C069102:oncogene protein E2, Human papillomavirus type 18
keywords: Epigenetics; Histone modification; Methylation; Papillomavirus; Transcription
references: J Acquir Immune Defic Syndr. 2005 Jun 1;39(2):143-51
references: 15905729
references: Int J Cancer. 2008 Oct 15;123(8):1832-40
references: 18688866
references: Nucleic Acids Res. 2012 Jan;40(Database issue):D912-7
references: 22075998
references: J Natl Cancer Inst. 2012 Nov 21;104(22):1738-49
references: 23093560
references: Genes Chromosomes Cancer. 1992 Sep;5(2):150-7
references: 1381951
references: J Clin Microbiol. 1995 Jul;33(7):1746-54
references: 7665641
references: Int J Cancer. 2013 Mar 15;132(6):1412-22
references: 22847263
references: J Virol. 2011 Nov;85(21):10999-1006
references: 21865393
references: J Pathol. 2013 Sep;231(1):53-62
references: 23674368
references: Genome Res. 2008 Nov;18(11):1851-8
references: 18714091
references: Cell Cycle. 2006 Jul;5(14):1499-502
references: 16861919
references: J Virol. 1997 Oct;71(10):7167-79
references: 9311789
references: Int J Cancer. 2007 May 15;120(10):2165-9
references: 17278110
references: Virology. 2006 Oct 25;354(2):280-5
references: 16905170
references: Arch Gynecol Obstet. 2012 May;285(5):1433-9
references: 22116316
references: J Med Virol. 2010 Feb;82(2):311-20
references: 20029805
references: Int J Cancer. 2013 May 1;132(9):2087-94
references: 23065631
references: J Virol. 1995 May;69(5):2989-97
references: 7707525
references: Semin Cancer Biol. 2009 Jun;19(3):144-52
references: 19429477
references: J Virol. 1999 Mar;73(3):1918-30
references: 9971771
references: Bioinformatics. 2008 Nov 1;24(21):2537-8
references: 18784119
references: Cancer Res. 1990 Feb 15;50(4):1316-23
references: 2153457
references: Virology. 2004 Jul 1;324(2):483-92
references: 15207633
references: J Biol Chem. 1997 Mar 28;272(13):8236-42
references: 9079642
references: Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2125-37
references: 23035178
references: J Infect Dis. 2012 Sep 15;206(6):867-74
references: 22740717
references: Carcinogenesis. 2010 May;31(5):918-26
references: 20123756
references: J Virol. 2012 May;86(9):5151-64
references: 22379087
references: J Virol. 2003 Dec;77(23):12450-9
references: 14610169
references: Virology. 2009 Aug 1;390(2):261-7
references: 19497607
references: Gynecol Oncol. 2011 Dec;123(3):597-604
references: 21911249
references: Mol Med Rep. 2008 Jul-Aug;1(4):555-60
references: 21479449
references: PLoS One. 2011;6(8):e23897
references: 21887341
references: Oncogene. 2012 May 3;31(18):2335-49
references: 21963854
references: New Biol. 1991 Jan;3(1):90-100
references: 1645591
references: Mol Cell. 2005 Dec 22;20(6):971-8
references: 16364921
references: J Virol. 2004 Dec;78(23):12762-72
references: 15542628
references: Oncol Rep. 2010 Dec;24(6):1599-604
references: 21042757
references: Virology. 2008 May 10;374(2):292-303
references: 18242658
references: J Virol. 1988 May;62(5):1640-6
references: 2833614
references: Cancer Res. 2011 Feb 1;71(3):1187-95
references: 21148070
references: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1654-8
references: 7878034
references: J Virol Methods. 2012 Sep;184(1-2):84-92
references: 22664184
references: PLoS One. 2012;7(11):e50533
references: 23226306
references: Virology. 2009 Jun 20;389(1-2):100-7
references: 19443004
references: Virology. 2006 May 25;349(1):175-83
references: 16472835
references: J Gen Virol. 1999 Jul;80 ( Pt 7):1725-1733
references: 10423141
references: Cancer. 2011 Mar 1;117(5):957-63
references: 20945322
references: PLoS One. 2011;6(9):e24451
references: 21915330
references: Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):215-20
references: 19819061
references: Int J Gynecol Cancer. 2009 Apr;19(3):321-5
references: 19407553
references: Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2130-5
references: 21245294