title: Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference.
abstract: Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a substantial obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest that new persistent spine formation in the frontal cortex may be involved in stimulant-related learning driving appetitive behavior.
authors: Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California, USA.
authors: Francisco Javier
authors: FJ
authors: Muñoz-Cuevas
authors: Jegath
authors: J
authors: Athilingam
authors: Denise
authors: D
authors: Piscopo
authors: Linda
authors: L
authors: Wilbrecht
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D049229:Dendritic Spines / Q000187:drug effects / Q000502:physiology; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology
chemical_list: D003042:Cocaine
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