title: DNA methylation in inflammatory bowel disease and beyond.
abstract: Inflammatory bowel disease (IBD) is a consequence of the complex, dysregulated interplay between genetic predisposition, environmental factors, and microbial composition in the intestine. Despite a great advancement in identifying host-susceptibility genes using genome-wide association studies (GWAS), the majority of IBD cases are still underrepresented. The immediate challenge in post-GWAS era is to identify other causative genetic factors of IBD. DNA methylation has received increasing attention for its mechanistical role in IBD pathogenesis. This stable, yet dynamic DNA modification, can directly affect gene expression that have important implications in IBD development. The alterations in DNA methylation associated with IBD are likely to outset as early as embryogenesis all the way until old-age. In this review, we will discuss the recent advancement in understanding how DNA methylation alterations can contribute to the development of IBD.
authors: Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
authors: Daren
authors: D
authors: Low
authors: Atsushi
authors: A
authors: Mizoguchi
authors: Emiko
authors: E
authors: Mizoguchi
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D004269:DNA, Bacterial / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D007422:Intestines / Q000382:microbiology; D010641:Phenotype; D012307:Risk Factors
chemical_list: D004269:DNA, Bacterial; D005765:Gastrointestinal Agents
keywords: Colitis; Crohn’s disease; DNA methyltransferase; Epi-therapy; Intestinal inflammation
references: Nat Rev Mol Cell Biol. 2003 Sep;4(9):721-32
references: 14506475
references: J Immunol. 2011 Jun 1;186(11):6505-14
references: 21515785
references: Eur J Intern Med. 2010 Aug;21(4):320-3
references: 20603044
references: Gastroenterology. 2004 Mar;126(3):796-808
references: 14988834
references: Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7
references: 22689992
references: Cancer Epidemiol Biomarkers Prev. 1997 Jun;6(6):469-71
references: 9184782
references: Nature. 1995 Apr 6;374(6522):546-9
references: 7700380
references: Am J Gastroenterol. 1997 Dec;92(12):2241-4
references: 9399762
references: Eur J Immunol. 2002 Jul;32(7):2084-92
references: 12115630
references: Science. 1996 Oct 11;274(5285):262-5
references: 8824194
references: Gut Microbes. 2013 Jan-Feb;4(1):84-8
references: 23137966
references: Nature. 2012 Nov 1;491(7422):119-24
references: 23128233
references: Inflamm Bowel Dis. 2011 Jan;17(1):171-8
references: 20848535
references: Arthritis Rheum. 2005 Oct;52(10):3004-14
references: 16200580
references: J Leukoc Biol. 2013 Jan;93(1):83-93
references: 23142729
references: Hum Mol Genet. 2010 Jun 1;19(11):2168-76
references: 20197410
references: Eur J Cancer. 2012 Sep;48(14):2270-81
references: 22244828
references: Gastroenterology. 2004 May;126(6):1504-17
references: 15168363
references: World J Gastroenterol. 2005 Oct 14;11(38):6038-42
references: 16273621
references: Nat Genet. 2008 Jun;40(6):713-5
references: 18438405
references: Cell. 2011 Sep 16;146(6):866-72
references: 21925312
references: Nature. 2010 Feb 25;463(7284):1101-5
references: 20098412
references: Nature. 2000 Dec 7;408(6813):740-5
references: 11130078
references: Nucleic Acids Res. 1982 Apr 24;10(8):2709-21
references: 7079182
references: Nat Genet. 2011 Mar;43(3):246-52
references: 21297633
references: J Immunol. 2001 Apr 15;166(8):5145-54
references: 11290797
references: J Leukoc Biol. 2009 Sep;86(3):663-70
references: 19620253
references: Nature. 2002 Jul 4;418(6893):99-103
references: 12097915
references: Inflamm Bowel Dis. 2011 Sep;17(9):1955-65
references: 21830274
references: J Immunol. 2009 Jan 1;182(1):259-73
references: 19109157
references: Mol Cancer Res. 2010 Apr;8(4):471-81
references: 20354000
references: Gastroenterology. 2009 Aug;137(2):569-78, 578.e1
references: 19375422
references: J Immunol. 2009 Sep 1;183(5):3109-17
references: 19648272
references: J Immunol. 2003 Aug 15;171(4):1647-51
references: 12902461
references: Hum Mol Genet. 2011 May 1;20(9):1687-96
references: 21296867
references: Cancer Cell. 2011 Nov 15;20(5):606-19
references: 22094255
references: Gastroenterology. 2009 Jul;137(1):209-20
references: 19303021
references: Inflamm Bowel Dis. 2008 Jul;14(7):968-76
references: 18253950
references: Oncogene. 2012 Mar 29;31(13):1733-42
references: 21841819
references: Gastroenterology. 2008 Sep;135(3):889-98, 898.e1-3
references: 18691581
references: PLoS One. 2012;7(9):e45287
references: 23028907
references: N Engl J Med. 1991 Sep 26;325(13):928-37
references: 1881418
references: Nature. 2008 Mar 6;452(7183):112-5
references: 18322535
references: EMBO J. 2006 Jun 7;25(11):2443-52
references: 16724115
references: Cancer. 2001 Feb 15;91(4):854-62
references: 11241255
references: Cell. 2000 Sep 1;102(5):553-63
references: 11007474
references: Inflamm Bowel Dis. 2012 Nov;18(11):2128-37
references: 22419656
references: FASEB J. 2011 May;25(5):1449-60
references: 21228220
references: Inflamm Bowel Dis. 2010 Nov;16(11):1871-81
references: 20848509
references: J Exp Med. 2001 May 7;193(9):1027-34
references: 11342587
references: J Cell Mol Med. 2011 Nov;15(11):2486-97
references: 21199330
references: J Clin Gastroenterol. 2008 May-Jun;42(5):481-6
references: 18344891
references: Eur J Gastroenterol Hepatol. 2006 Jun;18(6):615-21
references: 16702850
references: Pathol Res Pract. 2008;204(7):511-24
references: 18571874
references: Nucleic Acids Res. 2003 May 1;31(9):2261-71
references: 12711670
references: Inflamm Bowel Dis. 2012 May;18(5):889-99
references: 22021194
references: Gastroenterology. 2007 Apr;132(4):1254-60
references: 17408633
references: Science. 2009 May 15;324(5929):930-5
references: 19372391
references: Cell. 2011 Jul 8;146(1):67-79
references: 21722948
references: Blood. 2006 Aug 1;108(3):1058-64
references: 16861352
references: Nature. 2008 Mar 6;452(7183):45-50
references: 18322525
references: Am J Gastroenterol. 2008 Aug;103(8):1998-2006
references: 18796097
references: Trends Genet. 2012 Jan;28(1):33-42
references: 22019337
references: Science. 2012 Apr 27;336(6080):489-93
references: 22442383
references: Digestion. 2010;82(3):179-86
references: 20588031
references: Mol Immunol. 2013 Jul;54(3-4):264-70
references: 23328087
references: Dig Dis Sci. 2012 Dec;57(12):3145-53
references: 22821069
references: Surg Today. 2013 Nov;43(11):1275-80
references: 23307264
references: J Biol Chem. 2004 Dec 10;279(50):52353-60
references: 15448152
references: Carcinogenesis. 2012 Oct;33(10):1889-96
references: 22739025
references: Adv Immunol. 2007;94:37-73
references: 17560271
references: Nat Genet. 2010 Dec;42(12):1118-25
references: 21102463
references: Genome Res. 2012 Nov;22(11):2130-7
references: 22826509
references: Br J Nutr. 2013 Feb 28;109(4):630-8
references: 23021249
references: Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G623-34
references: 23275612
references: J Immunol. 2008 Sep 1;181(5):3099-107
references: 18713980
references: Mol Pharmacol. 2013 Jan;83(1):294-306
references: 23115325
references: J Biol Chem. 2008 Nov 21;283(47):32198-208
references: 18809684
references: Dig Dis Sci. 2007 Jul;52(7):1636-41
references: 17393334
references: Genes Dev. 2002 Jan 1;16(1):6-21
references: 11782440
references: Clin Genet. 2011 Jul;80(1):59-67
references: 20950376