title: Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases.
abstract: T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF- α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.
authors: Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
authors: Ning
authors: N
authors: Qu
authors: Mingli
authors: M
authors: Xu
authors: Izuru
authors: I
authors: Mizoguchi
authors: Jun-ichi
authors: J
authors: Furusawa
authors: Kotaro
authors: K
authors: Kaneko
authors: Kazunori
authors: K
authors: Watanabe
authors: Junichiro
authors: J
authors: Mizuguchi
authors: Masahiro
authors: M
authors: Itoh
authors: Yutaka
authors: Y
authors: Kawakami
authors: Takayuki
authors: T
authors: Yoshimoto
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism*; D020381:Interleukin-17 / Q000378:metabolism; D053759:Interleukin-23 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism*; D000097043:Interleukin-22
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D053759:Interleukin-23; D007378:Interleukins; D000097043:Interleukin-22
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