title: Lecithin-based emulsions for potential use as saliva substitutes in patients with xerostomia--viscoelastic properties.
abstract: The purpose of the present study was to investigate lecithin-rice bran oil rheological properties with the view to consider these as potential saliva substitutes in patients with severe xerostomia and salivary hypofunction. Pseudo-ternary phase diagrams of rice bran oil, lecithin and water mixtures were constructed and characterised using polarising light microscopy. Viscoelastic properties, which we hypothesise are important determinants in product performance, were analysed using both flow and oscillatory rheology. Rheological properties were influenced by composition, frequency and shear stress. Frequency-dependent viscoelasticity was observed in some formulations where viscosity dominated (tanδ>1) at frequencies under 5 Hz and elasticity dominated (tanδ<1) at higher frequencies. Threshold frequencies were determined for each formulation, where a peak in loss tangent was observed, coinciding with a reduction in the storage modulus and increase in loss modulus. The frequency-dependent behaviour of emulsions are of interest because these combinations exhibit viscous behaviour at low frequencies, which may improve lubrication of the oral cavity at rest, whereas increased elasticity at higher frequencies may improve retention during higher-shear tasks such as swallowing and speaking.
authors: School of Pharmacy, University of Otago, PO Box 56, Dunedin 9054, New Zealand. Electronic address: sara.hanning@otago.ac.nz.
authors: Sara M
authors: SM
authors: Hanning
authors: Tao
authors: T
authors: Yu
authors: David S
authors: DS
authors: Jones
authors: Gavin P
authors: GP
authors: Andrews
authors: Jules A
authors: JA
authors: Kieser
authors: Natalie J
authors: NJ
authors: Medlicott
mesh_terms: D004655:Emulsions; D006801:Humans; D054709:Lecithins / Q000008:administration & dosage / Q000737:chemistry*; D012463:Saliva / Q000737:chemistry*; D012464:Saliva, Artificial / Q000008:administration & dosage / Q000737:chemistry*; D055682:Viscoelastic Substances / Q000008:administration & dosage / Q000737:chemistry*; D014987:Xerostomia / Q000188:drug therapy
chemical_list: D004655:Emulsions; D054709:Lecithins; D012464:Saliva, Artificial; D055682:Viscoelastic Substances
keywords: Emulsion; Phase diagram; Rheology; Saliva substitute; Salivary hypofunction; Xerostomia