title: Preserving neural function under extreme scaling.
abstract: Important brain functions need to be conserved throughout organisms of extremely varying sizes. Here we study the scaling properties of an essential component of computation in the brain: the single neuron. We compare morphology and signal propagation of a uniquely identifiable interneuron, the HS cell, in the blowfly (Calliphora) with its exact counterpart in the fruit fly (Drosophila) which is about four times smaller in each dimension. Anatomical features of the HS cell scale isometrically and minimise wiring costs but, by themselves, do not scale to preserve the electrotonic behaviour. However, the membrane properties are set to conserve dendritic as well as axonal delays and attenuation as well as dendritic integration of visual information. In conclusion, the electrotonic structure of a neuron, the HS cell in this case, is surprisingly stable over a wide range of morphological scales.
authors: Department of Systems and Computational Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany ; Institute of Clinical Neuroanatomy, Goethe University, Frankfurt/Main, Germany ; Ernst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society, Frankfurt/Main, Germany.
authors: Hermann
authors: H
authors: Cuntz
authors: Friedrich
authors: F
authors: Forstner
authors: Bettina
authors: B
authors: Schnell
authors: Georg
authors: G
authors: Ammer
authors: Shamprasad Varija
authors: SV
authors: Raghu
authors: Alexander
authors: A
authors: Borst
mesh_terms: D000818:Animals; D003712:Dendrites / Q000502:physiology; D004175:Diptera / Q000033:anatomy & histology / Q000502:physiology*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000502:physiology*; D055724:Electrophysiological Phenomena; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology
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