title: Antinociceptive and anti-inflammatory activities of Sargassum wightii and Halophila ovalis sulfated polysaccharides in experimental animal models.
abstract: The present study investigated the effects of sulfated polysaccharides from brown seaweed Sargassum wightii (Sw-SP) and seagrass Halophila ovalis (Ho-SP) in nociceptive and inflammatory models. In the formalin test, Sw-SP and Ho-SP significantly reduced licking time in both phases of the test at a dose of 10 mg/kg. In the hot plate test, the antinociceptive effect was observed only in animals treated with 10 mg/kg of Sw-SP and 5, 10 mg/kg of Ho-SP, suggesting that the analgesic effect occurs through a central action mechanism at the higher dose. Sw-SP and Ho-SP (10 mg/kg) significantly inhibited paw edema induced by carrageenan, especially at 3 h after treatment and potentially decreased neutrophil migration by 53% and 52%, respectively. In Freund's adjuvant-induced arthritic rats, there was a significant increase in the rat paw volume and decrease in body weight, but in Sw-SP- and Ho-SP-treated groups (10 mg/kg), a significant reduction in paw volume and a normal gain in body weight were observed. The present results indicate that Sw-SP and Ho-SP possess antinociceptive and anti-inflammatory effects and have potential usefulness for development as therapeutic agents.
authors: Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry, India.
authors: Neelakandan
authors: N
authors: Yuvaraj
authors: Paulraj
authors: P
authors: Kanmani
authors: Ramraj
authors: R
authors: Satishkumar
authors: Alagesan
authors: A
authors: Paari
authors: Vellaiyan
authors: V
authors: Pattukumar
authors: Venkatesan
authors: V
authors: Arul
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001168:Arthritis / Q000188:drug therapy*; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D031321:Hydrocharitaceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage*; D017208:Rats, Wistar; D044647:Sargassum / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011134:Polysaccharides