title: Crohn's-like disease in a patient with common variable immunodeficiency treated with azathioprine and adalimumab.
abstract: Common variable immunodeficiency (CVID) is the most frequent primary antibody deficiency. It is characterized by recurrent bacterial infections, and occurrence of autoimmune and neoplastic diseases is also frequent; there is also a high prevalence of gastrointestinal diseases. There are reports of inflammatory bowel disease in this entity, but incidence is low (2-4 %). We present the case of a patient with common variable immunodeficiency suffering a chronic diarrhea episode and who was diagnosed with ileocaecal Crohn s-like disease after performing intestinal transit, CT abdomen and colonoscopy with biopsy. It was first treated with prednisone but on showing cortisone dependency, treatment with azathioprine and adalimumab was started, with good results.
authors: Juan María
authors: JM
authors: Vázquez-Morón
authors: Héctor
authors: H
authors: Pallarés-Manrique
authors: Ignacio Javier
authors: IJ
authors: Martín-Suárez
authors: Beatriz
authors: B
authors: Benítez-Rodríguez
authors: Manuel
authors: M
authors: Ramos-Lora
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use*; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy*; D003424:Crohn Disease / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; D000068879:Adalimumab; D001379:Azathioprine