title: Melanotic neuroectodermal tumor of infancy arising in the temporal bone.
abstract: Melanotic neuroectodermal tumor of infancy is a rare melanin-containing neoplasm with locally aggressive and rapid expansile growth, usually involving the maxilla, skull, and mandible of early infancy. Radical surgery is critical for a long-term outcome. We present a case of 14-month-old girl with rapid-growing subcutaneous mass arising in the right temporal bone and extending intracranially on computed tomographic scan. Radical surgery was performed. A brownish-black tumor composed of large pigmented epithelioid cells, positive for cytokeratins and HMB-45, and nests of small neuroblast-like cells positive for neuron-specific enolase and synaptophysin, was diagnosed as melanotic neuroectodermal tumor of infancy. The patient remained well without evidence of recurrence for 1 year after surgery. Clinicopathological features, management alternatives and outcome were discussed.
authors: Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.
authors: Jian-guo
authors: JG
authors: Zhang
authors: Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China. zhaoruijiao@126.com.
authors: Rui-jiao
authors: RJ
authors: Zhao
authors: Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, Henan, People's Republic of China.
authors: Ling-fei
authors: LF
authors: Kong
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D017600:Neuroectodermal Tumor, Melanotic / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D012888:Skull Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D013701:Temporal Bone / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: benign neoplasm; melanotic neuroectodermal tumor of infancy; temporal bone