title: Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer.
abstract: We retrospectively review outcomes of applying boron neutron capture therapy (BNCT) to unresectable advanced or recurrent head and neck cancers. Patients who were treated with BNCT for either local recurrent or newly diagnosed unresectable head or neck cancers between December 2001 and September 2007 were included. Clinicopathological characteristics and clinical outcomes were retrieved from hospital records. Either a combination of borocaptate sodium and boronophenylalanine (BPA) or BPA alone were used as boron compounds. In all the treatment cases, the dose constraint was set to deliver a dose <10-12 Gy-eq to the skin or oral mucosa. There was a patient cohort of 62, with a median follow-up of 18.7 months (range, 0.7-40.8). A total of 87 BNCT procedures were performed. The overall response rate was 58% within 6 months after BNCT. The median survival time was 10.1 months from the time of BNCT. The 1- and 2-year overall survival (OS) rates were 43.1% and 24.2%, respectively. The major acute Grade 3 or 4 toxicities were hyperamylasemia (38.6%), fatigue (6.5%), mucositis/stomatitis (9.7%) and pain (9.7%), all of which were manageable. Three patients died of treatment-related toxicity. Three patients experienced carotid artery hemorrhage, two of whom had coexistent infection of the carotid artery. This study confirmed the feasibility of our dose-estimation method and that controlled trials are warranted.
authors: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
authors: Minoru
authors: M
authors: Suzuki
authors: Ituro
authors: I
authors: Kato
authors: Teruhito
authors: T
authors: Aihara
authors: Junichi
authors: J
authors: Hiratsuka
authors: Kenichi
authors: K
authors: Yoshimura
authors: Miyuki
authors: M
authors: Niimi
authors: Yoshihiro
authors: Y
authors: Kimura
authors: Yasunori
authors: Y
authors: Ariyoshi
authors: Shin-Ichi
authors: S
authors: Haginomori
authors: Yoshinori
authors: Y
authors: Sakurai
authors: Yuko
authors: Y
authors: Kinashi
authors: Shin-Ichiro
authors: S
authors: Masunaga
authors: Masanori
authors: M
authors: Fukushima
authors: Koji
authors: K
authors: Ono
authors: Akira
authors: A
authors: Maruhashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016754:Boron Neutron Capture Therapy / Q000401:mortality*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000532:radiotherapy*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000532:radiotherapy*; D015995:Prevalence; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome
keywords: boron neutron capture therapy; head and neck tumors
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