title: Eye closure sensitivity in juvenile myoclonic epilepsy and its effect on prognosis.
abstract: OBJECTIVE
  To investigate eye closure sensitivity (ECS) in the EEGs of patients diagnosed with juvenile myoclonic epilepsy (JME) and its relationship to prognosis.
  
  
  METHODS
  We included 76 JME patients with a minimum follow-up of one year and evaluated a total of 254 EEGs to obtain evidence of ECS. The patients were grouped according to their response to treatment, and these subgroups were compared in relation to ECS and other clinical and EEG features.
  
  
  RESULTS
  There were 12 patients (15.8%) with poor prognosis who showed resistance to appropriate anti-epileptic drug treatment, 15 (19.7%) patients with pseudo-resistance, and 49 (64.5%) patients with good prognosis. The EEGs of only four of the patients displayed pure ECS (5.3%), and only one of these exhibited poor prognosis. Furthermore, 11 patients (14.5%) had both ECS and photosensitivity, and two of these patients exhibited poor prognosis. Thus, neither pure ECS nor ECS with photosensitivity correlated with poor prognosis. A family history of epilepsy and focal findings on the EEG was correlated with poorer prognosis.
  
  
  CONCLUSIONS
  ECS is a rare EEG finding in JME and does not appear to be a marker for poor prognosis.
authors: Bakirkoy Research and Training Hospital for Psychiatry, Neurology, Neurosurgery, Department of Neurology, Istanbul Zuhuratbaba-Bakırkoy, 34147 Istanbul, Turkey; Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Millet cad Fatih-Capa, 34390 Istanbul, Turkey. Electronic address: bguveli@hotmail.com.
authors: Betül
authors: B
authors: Tekin Güveli
authors: Betül
authors: B
authors: Baykan
authors: Nimet
authors: N
authors: Dörtcan
authors: Nerses
authors: N
authors: Bebek
authors: Candan
authors: C
authors: Gürses
authors: Ayşen
authors: A
authors: Gökyiğit
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001767:Blinking / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D011379:Prognosis
chemical_list: D000927:Anticonvulsants
keywords: EEG; Eye closure sensitivity; Juvenile myoclonic epilepsy; Prognosis; Theraphy