title: Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.
abstract: Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1.
authors: Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Equipe dénutritions maternelles périnatales, Université de Lille 1, Bâtiment SN4, 59655 Villeneuve d'Ascq, France.
authors: Jean-Sébastien
authors: JS
authors: Wattez
authors: Rozenn
authors: R
authors: Ravallec
authors: Benoit
authors: B
authors: Cudennec
authors: Claude
authors: C
authors: Knauf
authors: Pascal
authors: P
authors: Dhulster
authors: Philippe
authors: P
authors: Valet
authors: Christophe
authors: C
authors: Breton
authors: Didier
authors: D
authors: Vieau
authors: Jean
authors: J
authors: Lesage
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002766:Cholecystokinin / Q000378:metabolism*; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D051379:Mice; D051381:Rats
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C495199:apelin-13 peptide; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin
keywords: Apelin; Cholecystokinin; Glucagon-like peptide 1; Rat; STC-1 cells