title: Quantitative evaluation of the outcomes of revascularization procedures for peripheral arterial disease using indocyanine green angiography.
abstract: OBJECTIVE
  We performed indocyanine green angiography (ICGA) in patients with peripheral arterial disease (PAD), and established a method for the quantitative measurement of appropriate parameters to assess peripheral perfusion and the applicability of ICGA tests.
  
  
  METHODS
  Twenty-one patients with PAD underwent revascularization procedures with pre- and postinterventional ICGA tests. The ICGA parameters, which included the magnitude of intensity of indocyanine green, the time to maximum intensity, and the time from fluorescence onset to half the maximum intensity (T1/2) were compared with the ankle-brachial pressure index, toe -brachial pressure index, and toe pressure. We evaluated these parameters for regions of interest (ROIs).
  
  
  RESULTS
  T1/2 was the strongest parameter among all parameters of the ICGA tests. ROI 3, which included the distal region of the first metatarsal bone, correlated more significantly with the traditional measurements than the other ROIs. A value of T1/2 >20 seconds for ROI 3 was significantly correlated with a toe pressure of <50 mmHg (sensitivity: 0.77, specificity: 0.80).
  
  
  CONCLUSIONS
  ICGA can be used to assess peripheral tissue perfusion. By measuring the value of T1/2 in ROI 3, ICGA tests can be used to evaluate the outcomes of revascularization procedures.
authors: Department of Esophageal and General Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan. Electronic address: igari.srg1@tmd.ac.jp.
authors: K
authors: K
authors: Igari
authors: T
authors: T
authors: Kudo
authors: T
authors: T
authors: Toyofuku
authors: M
authors: M
authors: Jibiki
authors: Y
authors: Y
authors: Inoue
authors: T
authors: T
authors: Kawano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D057510:Endovascular Procedures; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012039:Regional Blood Flow; D013997:Time Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green
keywords: Bypass surgery; Critical limb ischemia; Endovascular treatment; Indocyanine green angiography; Peripheral arterial disease