title: Computer simulation of cardiac cryoablation: comparison with in vivo data.
abstract: Simulation of cardiac cryoablation by the finite element method can contribute to optimizing ablation results and understanding the effects of modifications prior to time-consuming and expensive experiments. In this work an intervention scenario using a 9 Fr 8 mm tip applicator applied to ventricular tissue was simulated using the effective heat capacity model based on Pennes' bioheat equation. Using experimentally obtained refrigerant flow rates and temperature profiles recorded by a thermocouple located at the tip of the applicator the cooling performance of the refrigerant was estimated and integrated by time and temperature dependent boundary conditions based on distinct phases of a freeze-thaw cycle. Our simulations exhibited a mean difference of approximately 6°C at the applicator tip compared to temperature profiles obtained during in vivo experiments. The presented model is a useful tool for simulation and validation of new developments in clinical cardiac cryoablation.
authors: Institute of Electrical and Biomedical Engineering, University for Health Sciences, Medical Informatics and Technology, Eduard Wallnöfer-Zentrum 1, 6060 Hall in Tirol, Austria. Electronic address: michael.handler@umit.at.
authors: Michael
authors: M
authors: Handler
authors: Gerald
authors: G
authors: Fischer
authors: Michael
authors: M
authors: Seger
authors: Roland
authors: R
authors: Kienast
authors: Claudia-Nike
authors: CN
authors: Nowak
authors: Daniel
authors: D
authors: Pehböck
authors: Florian
authors: F
authors: Hintringer
authors: Christian
authors: C
authors: Baumgartner
mesh_terms: D055011:Ablation Techniques; D000818:Animals; D006348:Cardiac Surgical Procedures; D003452:Cryosurgery; D020342:Finite Element Analysis; D013552:Swine; D013696:Temperature
keywords: Cardiac cryoablation; Finite element method; In vivo validation; Modeling and simulation; Pennes’ bioheat equation; Temperature profile