title: Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity.
abstract: Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe autoimmune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peritumoral delivery of low doses of this immunomodulatory drug can trigger a systemic antitumor immune response while preventing the toxicity against other organs.
authors: Authors' Affiliations: Department of Medicine, Division of Oncology, Stanford University, Stanford, California; and Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.
authors: Aurélien
authors: A
authors: Marabelle
authors: Holbrook
authors: H
authors: Kohrt
authors: Ronald
authors: R
authors: Levy
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D019138:Antibodies, Blocking / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology
chemical_list: D019138:Antibodies, Blocking; D000911:Antibodies, Monoclonal; D060908:CTLA-4 Antigen
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