title: Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa.
abstract: As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.
authors: *Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; †Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; ‡National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau; §National Public Health Laboratory, Bissau, Guinea-Bissau; ‖GloHAU, Center for Global Health, School of Public Health, Aarhus University, Aarhus, Denmark; and ¶Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
authors: Bo Langhoff
authors: BL
authors: Hønge
authors: Magnús Pétur
authors: MP
authors: Bjarnason Obinah
authors: Sanne
authors: S
authors: Jespersen
authors: Candida
authors: C
authors: Medina
authors: David da Silva
authors: Dda S
authors: Té
authors: Zacarias José
authors: ZJ
authors: da Silva
authors: Lars
authors: L
authors: Østergaard
authors: Alex Lund
authors: AL
authors: Laursen
authors: Christian
authors: C
authors: Wejse
authors: Christian
authors: C
authors: Erikstrup
mesh_terms: D015492:AIDS Serodiagnosis / Q000379:methods* / Q000706:statistics & numerical data; D000328:Adult; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000175:diagnosis; D005260:Female; D006169:Guinea-Bissau / Q000453:epidemiology; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D015497:HIV-1; D015498:HIV-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity