title: [A case of apple allergy with initial symptoms like food-dependent exercise-induced anaphylaxis].
abstract: A 13-year-old boy with two episodes of anaphylaxis after exercise was suspected as food-dependent exercise-induced anaphylaxis (FEIAn). The exercise challenge test after ingestion of an apple was performed, because apple was commonly contained in meals before the both episodes and a prick test for apple was positive. The exercise test was positive accompanied with nasal discharge, sneezing, throat discomfort, swelling of the uvula. The patient was instructed to refrain from exercise for 4 hours after ingestion of apple. In five months, he developed allergic symptoms only by an intake of foods containing heated apple without exercise and showed a slight increase in apple-specific IgE from negative to 0.51 IU/ml. The prognosis of FEIAn has not been well described. Cases with FEIAn to apples like this case require a close follow-up in consideration of development of allergic reactions without exercise.
authors: Department of Pediatrics, Gunma University, Graduate School of Medicine.
authors: Mari
authors: M
authors: Kaneko
authors: Hisako
authors: H
authors: Yagi
authors: Harumi
authors: H
authors: Koyama
authors: Naoki
authors: N
authors: Nakajima
authors: Reiko
authors: R
authors: Muramatu
authors: Takumi
authors: T
authors: Takizawa
authors: Hirokazu
authors: H
authors: Arakawa
mesh_terms: D000293:Adolescent; D000707:Anaphylaxis / Q000209:etiology*; D001250:Asthma, Exercise-Induced / Q000175:diagnosis* / Q000209:etiology; D001985:Bronchial Provocation Tests; D005080:Exercise Test; D005512:Food Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D008297:Male; D027845:Malus / Q000276:immunology*