title: Aqueous soluble vascular endothelial growth factor receptor-2 in macular edema with branch retinal vein occlusion.
abstract: OBJECTIVE
  The aqueous humor level of soluble vascular endothelial growth factor receptor (sVEGFR)-2 may influence macular edema in patients with branch retinal vein occlusion (BRVO). The association of sVEGFR-2 with macular edema was investigated in this study.
  
  
  METHODS
  A retrospective case-controlled study was performed in 22 patients with BRVO and macular edema, as well as 5 patients with non-ischemic ocular diseases as the control group. The severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during intravitreous injection of anti-VEGF agents, triamcinolone acetonide, or combined vitrectomy and cataract surgery. sVEGFR-2 levels in aqueous humor were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The aqueous humor level of sVEGFR-2 (median: 124.5 ng/ml) was significantly elevated in BRVO patients compared with the control group (78.1 pg/ml) (p = 0.010). In addition, the sVEGFR-2 level was correlated with the severity of macular edema (p = 0.033).
  
  
  CONCLUSIONS
  sVEGFR-2 may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sVEGFR-2 levels may be helpful for understanding the disease status in BRVO patients with macular edema.
authors: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University , Chiba , Japan and.
authors: Hidetaka
authors: H
authors: Noma
authors: Tatsuya
authors: T
authors: Mimura
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012167:Retinal Perforations / Q000378:metabolism* / Q000473:pathology; D012170:Retinal Vein Occlusion / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies; D012995:Solubility; D041623:Tomography, Optical Coherence; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D040301:Vascular Endothelial Growth Factor Receptor-2