title: Gas gangrene caused by clostridium perfringens involving the liver, spleen, and heart in a man 20 years after an orthotopic liver transplant: a case report.
abstract: Despite advances in immunosuppression and liver transplant in the past, mortality and morbidity caused by infections remain major problems. We present a 71-year-old man who was admitted to our internal intensive care unit with septicemia. Upon admission, he had poorly localized epigastric pain and fever of 2 days ' duration. Twenty years earlier, he had undergone an orthotopic liver transplant. Testing revealed a high C-reactive protein level, elevated liver enzymes, and an acute kidney injury. A computer tomography scan showed 2 circular, non--rim-enhancing, totally emphysematous intrahepatic lesions. Additionally, gas could be seen in the portal veins mainly, as well as in the biliary system, in the right auricle, and the splenic veins. To the best of our knowledge, he showed no malignant lesion or predisposing trauma. Empirically, treatment with broad-spectrum antibiotics was begun, and the patient was transferred to the operating suite. When surgery began, blood cultures revealed the presence of gram-positive bacilli, which were identified as Clostridium perfringens. Seven hours after the surgery, the patient developed asystole and died. In septic patients presenting with severe hemolysis, Clostridium perfringens infection must be considered in the absence of a malignant lesion or a predisposing trauma; a previous episode of gastroenteritis might be a predisposing trauma by impairing the barrier of the intestinal flora, leading to Clostridium perfringens infection.
authors: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany.
authors: Daniel
authors: D
authors: Kitterer
authors: Niko
authors: N
authors: Braun
authors: Margit C
authors: MC
authors: Jehs
authors: Bernhard
authors: B
authors: Schulte
authors: M Dominik
authors: MD
authors: Alscher
authors: Joerg
authors: J
authors: Latus
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003016:Clostridium perfringens / Q000472:pathogenicity*; D017809:Fatal Outcome; D005738:Gas Gangrene / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006331:Heart Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008100:Liver Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D012086:Reoperation; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis / Q000382:microbiology; D013158:Splenic Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents