title: Alkalizer administration improves renal function in hyperuricemia associated with obesity.
abstract: We evaluated the combination effect of the alkalizer citrate with the xanthine oxidase inhibitor allopurinol on renal function and uric acid in patients with hyperuricemia associated with obesity and/or metabolic syndrome (MetS), who were extracted from among the subjects enrolled in a prospective randomized controlled study aimed at assessing the efficacy of such a combination for improving renal function. We also conducted a post hoc analysis to examine influences on lipid profiles. Patients who consented to participate in the study were randomly allocated to receive either allopurinol alone (monotherapy) or in combination with a citrate preparation (combination therapy). The analysis population consisted of 31 obese patients with a body mass index greater than 25 kg/m(2) (monotherapy, 15 patients; combination therapy, 16 patients). The creatinine clearance rate (Ccr), serum uric acid levels, and lipid profiles were measured before and at 12 weeks after the start of treatment. In the combination therapy group, Ccr increased significantly and serum uric acid levels decreased significantly in obese patients, while Ccr tended to increase and serum uric acid levels decreased, though not significantly, in patients with MetS-related clinical parameters. Overall, blood triglyceride levels tended to improve in the combination therapy group as compared with the monotherapy group.
authors: Division of Endocrinology and Metabolism, Endocrinology and Diabetic center, Department of Medicine, Yokohama Rosai Hospital.
authors: Jun
authors: J
authors: Saito
authors: Yoko
authors: Y
authors: Matsuzawa
authors: Hiroko
authors: H
authors: Ito
authors: Masao
authors: M
authors: Omura
authors: Tomoshige
authors: T
authors: Kino
authors: Tetsuo
authors: T
authors: Nishikawa
keywords: Obesity; alkalizer; citrate; hyperuricemia; renal function
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