title: Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin-induced nephrotoxicity in rats.
abstract: This study aimed to assess the protective effect of cinnamic acid (CA) and cinnamaldehyde (CD) against cisplatin-induced nephrotoxicity. A single dose of cisplatin (5 mg/kg), injected intraperitoneally to male rats, caused significant increases in serum urea, creatinine levels, and lipid peroxides measured as the malondialdehyde content of kidney, with significant decreases in serum albumin, reduced glutathione, and the activity of antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) of kidney as compared with the control group. On the other hand, administration of CA (50 mg/kg, p.o.) or CD (40 mg/kg, p.o.) for 7 days before cisplatin ameliorated the cisplatin-induced nephrotoxicity as indicated by the restoration of kidney function and oxidative stress parameters. Furthermore, they reduced the histopathological changes induced by cisplatin. In conclusion, CA and CD showed protective effects against cisplatin-induced nephrotoxicity where CD was more effective than CA; affects that might be attributed to their antioxidant activities.
authors: Pharmacolgy and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt. elsayed200_1956@hotmail.com.
authors: El-Sayed M
authors: el-SM
authors: El-Sayed
authors: Ola M
authors: OM
authors: Abd El-Raouf
authors: Hala M
authors: HM
authors: Fawzy
authors: Mohamed F
authors: MF
authors: Manie
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000494:pharmacology; D000418:Albumins / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002934:Cinnamates / Q000494:pharmacology*; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000418:Albumins; D000970:Antineoplastic Agents; D000975:Antioxidants; D002934:Cinnamates; D017392:Thiobarbituric Acid Reactive Substances; C029010:cinnamic acid; D000171:Acrolein; D003404:Creatinine; D002945:Cisplatin; C012843:cinnamaldehyde
keywords: Anti-Oxidant; Cinnamaldehyde; Cinnamic Acid; Cisplatin; Nephrotoxicity