title: Additive genetic variation in schizophrenia risk is shared by populations of African and European descent.
abstract: To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European descent (ED [n = 4,990]) schizophrenia case-control genome-wide association study (GWAS) data set available, the Molecular Genetics of Schizophrenia (MGS) data set. We show how a method that uses genomic similarities at measured SNPs to estimate the additive genetic correlation (SNP correlation [SNP-rg]) between traits can be extended to estimate SNP-rg for the same trait between ethnicities. We estimated SNP-rg for schizophrenia between the MGS ED and MGS AD samples to be 0.66 (SE = 0.23), which is significantly different from 0 (p(SNP-rg = 0) = 0.0003), but not 1 (p(SNP-rg = 1) = 0.26). We re-estimated SNP-rg between an independent ED data set (n = 6,665) and the MGS AD sample to be 0.61 (SE = 0.21, p(SNP-rg = 0) = 0.0003, p(SNP-rg = 1) = 0.16). These results suggest that many schizophrenia risk alleles are shared across ethnic groups and predate African-European divergence.
authors: Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80302, USA. teresa.decandia@colorado.edu
authors: Teresa R
authors: TR
authors: de Candia
authors: S Hong
authors: SH
authors: Lee
authors: Jian
authors: J
authors: Yang
authors: Brian L
authors: BL
authors: Browning
authors: Pablo V
authors: PV
authors: Gejman
authors: Douglas F
authors: DF
authors: Levinson
authors: Bryan J
authors: BJ
authors: Mowry
authors: John K
authors: JK
authors: Hewitt
authors: Michael E
authors: ME
authors: Goddard
authors: Michael C
authors: MC
authors: O'Donovan
authors: Shaun M
authors: SM
authors: Purcell
authors: Danielle
authors: D
authors: Posthuma
authors: Peter M
authors: PM
authors: Visscher
authors: Naomi R
authors: NR
authors: Wray
authors: Matthew C
authors: MC
authors: Keller
mesh_terms: D000349:Africa / Q000208:ethnology; D044383:Black People / Q000235:genetics*; D015331:Cohort Studies; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency / Q000235:genetics; D005789:Genealogy and Heraldry; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000235:genetics*
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