title: Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model.
abstract: METHODS
  Metabolic syndrome has become an epidemic and poses tremendous burden on the health system. People with metabolic syndrome are more likely to experience cognitive decline. As obesity and sedentary lifestyles become more common, the development of early prevention strategies is critical. In this study, we explore the potential beneficial effects of a combinatory polyphenol preparation composed of grape seed extract, Concord purple grape juice extract, and resveratrol, referred to as standardized grape polyphenol preparation (SGP), on peripheral as well as brain dysfunction induced by metabolic syndrome.
  
  
  RESULTS
  We found dietary fat content had minimal effect on absorption of metabolites of major polyphenols derived from SGP. Using a diet-induced animal model of metabolic syndrome (DIM), we found that brain functional connectivity and synaptic plasticity are compromised in the DIM mice. Treatment with SGP not only prevented peripheral metabolic abnormality but also improved brain synaptic plasticity.
  
  
  CONCLUSIONS
  Our study demonstrated that SGP, comprised of multiple bioavailable and bioactive components targeting a wide range of metabolic syndrome related pathological features, provides greater global protection against peripheral and central nervous system dysfunctions and can be potentially developed as a novel prevention/treatment for improving brain connectivity and synaptic plasticity important for learning and memory.
authors: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ, USA.
authors: Jun
authors: J
authors: Wang
authors: Cheuk
authors: C
authors: Tang
authors: Mario G
authors: MG
authors: Ferruzzi
authors: Bing
authors: B
authors: Gong
authors: Brian J
authors: BJ
authors: Song
authors: Elsa M
authors: EM
authors: Janle
authors: Tzu-Ying
authors: TY
authors: Chen
authors: Bruce
authors: B
authors: Cooper
authors: Merina
authors: M
authors: Varghese
authors: Alice
authors: A
authors: Cheng
authors: Daniel
authors: D
authors: Freire
authors: Amanda
authors: A
authors: Bilski
authors: Jessica
authors: J
authors: Roman
authors: Tuyen
authors: T
authors: Nguyen
authors: Lap
authors: L
authors: Ho
authors: Stephen T
authors: ST
authors: Talcott
authors: James E
authors: JE
authors: Simon
authors: Qingli
authors: Q
authors: Wu
authors: Giulio M
authors: GM
authors: Pasinetti
mesh_terms: D000818:Animals; D001682:Biological Availability; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004041:Dietary Fats / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D056604:Grape Seed Extract / Q000494:pharmacology; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000187:drug effects*; D059808:Polyphenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects*; D027843:Vitis / Q000737:chemistry*
chemical_list: D004041:Dietary Fats; D056604:Grape Seed Extract; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol
keywords: Metabolic syndrome; Polyphenols; Standardized grape polyphenol preparation; Synaptic plasticity
references: Nutrition. 2006 Nov-Dec;22(11-12):1137-45
references: 17030113
references: Transl Neurosci. 2012 Mar 1;3(1):9-14
references: 23459252
references: Am J Clin Nutr. 1997 Aug;66(2):261-6
references: 9250103
references: IEEE Trans Med Imaging. 2004 Feb;23(2):137-52
references: 14964560
references: Biol Psychiatry. 2010 Mar 15;67(6):505-12
references: 19358976
references: FASEB J. 2005 Apr;19(6):659-61
references: 15650008
references: Dement Geriatr Cogn Disord. 2007;23(1):29-34
references: 17068394
references: J Clin Invest. 2007 Nov;117(11):3393-402
references: 17965777
references: Brain Res. 1992 Jan 20;570(1-2):134-43
references: 1617405
references: Obesity (Silver Spring). 2010 Mar;18(3):463-9
references: 19730425
references: J Biol Chem. 2010 Mar 19;285(12):9100-13
references: 20080969
references: J Am Geriatr Soc. 2007 May;55(5):758-62
references: 17493197
references: Neuroscience. 2003;120(2):535-9
references: 12890522
references: Diabetes Care. 2007 Oct;30(10):2655-60
references: 17563341
references: Cardiovasc Psychiatry Neurol. 2009;2009:107286
references: 19936102
references: Endocrinology. 2004 Nov;145(11):4985-90
references: 15271880
references: J Alzheimers Dis. 2010;22(2):653-61
references: 20858961
references: Br J Nutr. 2010 Oct;104 Suppl 3:S67-90
references: 20955651
references: Metabolism. 2009 Dec;58(12):1743-6
references: 19608210
references: Annu Rev Nutr. 2001;21:381-406
references: 11375442
references: Cell. 2006 Dec 15;127(6):1109-22
references: 17112576
references: Nature. 1997 Jun 5;387(6633):561
references: 9177339
references: J Agric Food Chem. 2010 Jun 9;58(11):6685-91
references: 20446738
references: Hippocampus. 2008;18(11):1085-8
references: 18651634
references: Int J Mol Sci. 2010 Mar 31;11(4):1365-402
references: 20480025
references: J Neurosci. 2008 Jun 18;28(25):6388-92
references: 18562609
references: J Neurosci. 2012 Apr 11;32(15):5144-50
references: 22496560
references: Natl Health Stat Report. 2009 May 5;(13):1-7
references: 19634296
references: Nutrition. 2011 Jun;27(6):617-23
references: 21367579
references: J Agric Food Chem. 2004 Sep 8;52(18):5593-7
references: 15373398
references: Nature. 2006 Nov 16;444(7117):337-42
references: 17086191
references: Metabolism. 1995 May;44(5):645-51
references: 7752914
references: Arch Neurol. 2007 Jan;64(1):93-6
references: 17210814
references: J Nutr Biochem. 2010 Oct;21(10):961-7
references: 19962298
references: Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
references: 16087444
references: J Alzheimers Dis. 2009;16(1):59-72
references: 19158422
references: Dement Geriatr Cogn Disord. 2007;24(3):185-92
references: 17641531
references: Neuroscience. 2002;113(3):607-15
references: 12150780
references: Biochem Pharmacol. 2006 Nov 30;72(11):1439-52
references: 16920072
references: Arch Surg. 2011 May;146(5):556-64
references: 21739664
references: Br J Nutr. 2010 Mar;103(5):730-4
references: 20028599
references: Pharmacol Res. 2005 Sep;52(3):264-70
references: 15925517
references: J Agric Food Chem. 2004 Feb 25;52(4):1008-16
references: 14969564
references: J Agric Food Chem. 2011 Oct 12;59(19):10586-93
references: 21879745
references: Neuroimage. 2010 Feb 1;49(3):2163-77
references: 19896537
references: Neurology. 2007 Sep 4;69(10):979-85
references: 17785666