title: Structural properties of polyphenols causing cell cycle arrest at G1 phase in HCT116 human colorectal cancer cell lines.
abstract: Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure-activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest.
authors: Department of Biological Sciences, Konkuk University, Seoul 143-701, Korea. shinsy@konkuk.ac.kr
authors: Soon Young
authors: SY
authors: Shin
authors: Hyuk
authors: H
authors: Yoon
authors: Seunghyun
authors: S
authors: Ahn
authors: Dong-Wook
authors: DW
authors: Kim
authors: Dong-Ho
authors: DH
authors: Bae
authors: Dongsoo
authors: D
authors: Koh
authors: Young Han
authors: YH
authors: Lee
authors: Yoongho
authors: Y
authors: Lim
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms; D004354:Drug Screening Assays, Antitumor; D059585:G1 Phase Cell Cycle Checkpoints; D045325:HCT116 Cells; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship
chemical_list: D016588:Anticarcinogenic Agents; D010936:Plant Extracts; D059808:Polyphenols
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