title: RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication.
abstract: Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications.
authors: Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences , Kanazawa , Japan.
authors: Yasuhiko
authors: Y
authors: Yamamoto
authors: Hiroshi
authors: H
authors: Yamamoto
keywords: inflammation; obesity; pattern-recognition receptors; rage; toll-like receptors
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