title: Structural Biology: Parkin's Serpentine Shape Revealed in the Year of the Snake.
abstract: Parkin is an E3 ubiquitin ligase, mutations in which are responsible for autosomal recessive juvenile parkinsonism. Recently, several structures of Parkin have been solved, revealing its serpentine shape and modes of auto-inhibition.
authors: Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
authors: Katja K
authors: KK
authors: Dove
authors: Rachel E
authors: RE
authors: Klevit
mesh_terms: D000818:Animals; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D051381:Rats; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein