title: A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers.
abstract: Background. Thyroid status may influence tumorigenesis of gynecologic cancers, yet epidemiologic studies of this relationship are limited and inconsistent. Methods. We evaluated the association of self-reported history of physician-diagnosed hypothyroidism and hyperthyroidism with medical-record confirmed endometrial (EC; all invasive adenocarcinomas) and ovarian cancer (OC; epithelial ovarian or peritoneal cancers) in Nurses' Health Study (NHS) from 1976 to 2010 and NHSII from 1989 to 2011. Cox proportional hazard models were used to estimate multivariable rate ratios (RRs) and 95% confidence intervals based on pooled cohort data. Results. We confirmed 1314 incident cases of EC and 1150 cases of OC. Neither a history of hypothyroidism nor hyperthyroidism was significantly associated with risk of EC or OC. However, having a history of hypothyroidism for 8+ years (median) was nonsignificantly inversely associated with EC (RR = 0.81; 95% CI = 0.63-1.04; P-trend with history duration = 0.11) and OC (RR = 0.87, 95% CI = 0.66-1.15; P-trend = 0.13). Having a history of hyperthyroidism for 6+ years (median) was non-significantly positively associated with EC (RR = 1.69; 95% CI = 0.86-3.30; P-trend = 0.12) but not OC (RR = 1.12; 95% CI = 0.46-2.72; P-trend = 0.95). Conclusions. A history of hypothyroidism or hyperthyroidism was not significantly associated with risk of EC or OC.
authors: Channing Division of Network Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Jae H
authors: JH
authors: Kang
authors: Angela S
authors: AS
authors: Kueck
authors: Richard
authors: R
authors: Stevens
authors: Gary
authors: G
authors: Curhan
authors: Immaculata
authors: I
authors: De Vivo
authors: Bernard
authors: B
authors: Rosner
authors: Erik
authors: E
authors: Alexander
authors: Shelley S
authors: SS
authors: Tworoger
references: Arch Intern Med. 2005 Jul 25;165(14):1606-11
references: 16043678
references: Epidemiology. 2000 Mar;11(2):111-7
references: 11021606
references: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references: 22237781
references: Am J Obstet Gynecol. 2008 Feb;198(2):218.e1-6
references: 18226630
references: Best Pract Res Clin Endocrinol Metab. 2004 Jun;18(2):153-65
references: 15157833
references: Mod Pathol. 2012 Aug;25(8):1140-8
references: 22460811
references: Adv Anat Pathol. 2002 May;9(3):145-84
references: 11981113
references: Cancer Lett. 2011 Feb 28;301(2):119-26
references: 21183275
references: Endocr Rev. 2010 Oct;31(5):702-55
references: 20573783
references: J Clin Endocrinol Metab. 2007 Jan;92(1):322-7
references: 17032711
references: Biochim Biophys Acta. 2013 Jul;1830(7):3908-16
references: 22484490
references: In Vivo. 1996 Mar-Apr;10(2):245-7
references: 8744809
references: Cancer. 2005 Mar 15;103(6):1122-8
references: 15712375
references: J Clin Endocrinol Metab. 1975 Sep;41(3):491-7
references: 1159057
references: J Reprod Immunol. 2011 Jun;90(1):58-66
references: 21641659
references: Fertil Steril. 2000 Dec;74(6):1063-70
references: 11119728
references: Eur J Cancer. 1997 Sep;33(10):1634-7
references: 9389926
references: Urology. 1990 Jun;35(6):492-8
references: 2353376
references: Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):543-7
references: 18698261
references: Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):570-4
references: 19155436
references: J Natl Cancer Inst. 1998 Dec 2;90(23):1774-86
references: 9839517
references: JAMA. 1984 Feb 3;251(5):616-9
references: 6690834
references: Ann Intern Med. 2012 Jul 3;157(1):ITC1-16
references: 22751778
references: Cancer Res. 1990 Apr 15;50(8):2283-9
references: 2317816
references: Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):432-6
references: 20689420
references: Best Pract Res Clin Obstet Gynaecol. 2008 Apr;22(2):235-49
references: 17804298
references: Proc R Soc Med. 1972 Sep;65(9):789-90
references: 5085068
references: Thyroid. 2004;14 Suppl 1:S5-15
references: 15142372
references: Gynecol Oncol. 2007 Dec;107(3):487-94
references: 17825884
references: Fertil Steril. 1995 Mar;63(3):535-42
references: 7851583
references: Obstet Gynecol Surv. 2002 Mar;57(3 Suppl):S1-7
references: 12074547
references: Endocr Rev. 2010 Apr;31(2):139-70
references: 20051527
references: Trends Endocrinol Metab. 2009 Sep;20(7):318-24
references: 19716314
references: Fertil Steril. 2011 Jan;95(1):230-7, 237.e1-2
references: 20691434
references: J Natl Cancer Inst. 2010 Apr 21;102(8):568-72
references: 20305129
references: Am J Obstet Gynecol. 1983 Jun 15;146(4):380-3
references: 6305196
references: J Obstet Gynaecol Br Commonw. 1974 Oct;81(10):795-803
references: 4419555
references: Int J Gynecol Cancer. 2001 Sep-Oct;11(5):339-48
references: 11737463
references: Breast Cancer Res Treat. 2012 Jun;133(3):1169-77
references: 22434524
references: Tissue Cell. 2003 Aug;35(4):260-73
references: 12921709
references: JAMA. 1998 Jul 22-29;280(4):347-55
references: 9686552
references: Braz J Med Biol Res. 2005 May;38(5):761-5
references: 15917958
references: Thyroid. 2005 Nov;15(11):1253-9
references: 16356089
references: J Natl Cancer Inst. 1996 Aug 21;88(16):1127-35
references: 8757192
references: Endocrinology. 2005 Jul;146(7):2864-71
references: 15802494