title: Effectiveness of trimethoprim-sulfamethoxazole and metronidazole in the treatment of small intestinal bacterial overgrowth in children living in a slum.
abstract: Trimethoprim-sulfamethoxazole and metronidazole were used for 14 days to treat 20 children with small intestine bacterial overgrowth (SIBO). SIBO was diagnosed using the lactulose hydrogen breath test. The breath test was repeated 1 month after treatment, and 19 (95.0%) of 20 children showed no evidence of SIBO (P < 0.001). The area under the individual curves showed that children with SIBO exhibited greater hydrogen production before treatment in both the first hour and between 60 and 180 minutes after the breath test. The treatment did not decrease methane production. In conclusion, trimethoprim-sulfamethoxazole and metronidazole was effective in treating children with SIBO.
authors: Pediatric Gastroenterology Division, Pediatric Department, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors: Soraia
authors: S
authors: Tahan
authors: Lígia Cristina F L
authors: LC
authors: Melli
authors: Carolina Santos
authors: CS
authors: Mello
authors: Mírian Silva C
authors: MS
authors: Rodrigues
authors: Humberto
authors: H
authors: Bezerra Filho
authors: Mauro B
authors: MB
authors: de Morais
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D001944:Breath Tests; D002648:Child; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology*; D007792:Lactulose / Q000378:metabolism; D008795:Metronidazole / Q000627:therapeutic use*; D011203:Poverty; D012111:Residence Characteristics; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D007792:Lactulose; D006859:Hydrogen; D015662:Trimethoprim, Sulfamethoxazole Drug Combination