title: Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.
abstract: The homeobox transcription factor Pitx2 displays a highly specific expression pattern during embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left-right signaling. Conditional deletion in mice has demonstrated a complex and intricate role for Pitx2 in distinct aspects of cardiac development and more recently a link to atrial fibrillation has been proposed based on genome-wide association studies. In this review we will revise the role of Pitx2 in the developing heart, starting from the early events of left-right determination followed by its role in cardiac morphogenesis and ending with its role in cardiac arrhythmogenesis.
authors: Department of Experimental Biology B3-362, University of Jaén, Jaen 23071, Spain. Electronic address: dfranco@ujaen.es.
authors: Diego
authors: D
authors: Franco
authors: Heart Failure Research Centre, Academic Medical Centre, Amsterdam, The Netherlands.
authors: Vincent M
authors: VM
authors: Christoffels
authors: CNR-Institute of Neurosciences, Department of Biomedical Sciences, University of Padua, Padua, Italy.
authors: Marina
authors: M
authors: Campione
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease; D006321:Heart / Q000196:embryology* / Q000503:physiopathology; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis; D009206:Myocardium / Q000378:metabolism*; D010641:Phenotype; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D000097577:Homeobox Protein PITX2
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2