title: Age-related decline of precision and binding in visual working memory.
abstract: Working memory declines with normal aging, but the nature of this impairment is debated. Studies based on detecting changes to arrays of visual objects have identified two possible components to age-related decline: a reduction in the number of items that can be stored, or a deficit in maintaining the associations (bindings) between individual object features. However, some investigations have reported intact binding with aging, and specific deficits arising only in Alzheimer's disease. Here, using a recently developed continuous measure of recall fidelity, we tested the precision with which adults of different ages could reproduce from memory the orientation and color of a probed array item. The results reveal a further component of cognitive decline: an age-related decrease in the resolution with which visual information can be maintained in working memory. This increase in recall variability with age was strongest under conditions of greater memory load. Moreover, analysis of the distribution of errors revealed that older participants were more likely to incorrectly report one of the unprobed items in memory, consistent with an age-related increase in misbinding. These results indicate a systematic decline with age in working memory resources that can be recruited to store visual information. The paradigm presented here provides a sensitive index of both memory resolution and feature binding, with the potential for assessing their modulation by interventions. The findings have implications for understanding the mechanisms underpinning working memory deficits in both health and disease.
authors: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology.
authors: Muy-Cheng
authors: MC
authors: Peich
authors: Masud
authors: M
authors: Husain
authors: Paul M
authors: PM
authors: Bays
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology / Q000523:psychology*; D003118:Color Perception / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009949:Orientation / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
references: J Exp Psychol Learn Mem Cogn. 2000 Sep;26(5):1170-87
references: 11009251
references: Arch Clin Neuropsychol. 1997;12(1):29-40
references: 14588432
references: Brain. 2010 Sep;133(9):2702-13
references: 20624814
references: J Vis. 2004 Dec 29;4(12):1120-35
references: 15669916
references: J Vis. 2011 Oct 06;11(12):
references: 21980189
references: J Neurol. 2010 Jul;257(7):1160-9
references: 20162428
references: J Vis. 2009 Sep 09;9(10):7.1-11
references: 19810788
references: Psychol Sci. 2010 Mar;21(3):399-405
references: 20424077
references: Science. 2008 Aug 8;321(5890):851-4
references: 18687968
references: Proc Natl Acad Sci U S A. 2012 May 29;109(22):8780-5
references: 22582168
references: Psychol Sci. 2004 Feb;15(2):106-11
references: 14738517
references: Psychol Aging. 2011 Sep;26(3):612-24
references: 21463062
references: Annu Rev Psychol. 1991;42:333-76
references: 2018397
references: Cereb Cortex. 2011 May;21(5):1147-54
references: 20884722
references: J Vis. 2010 Oct 22;10(12):27
references: 21047759
references: Psychon Bull Rev. 2008 Jun;15(3):543-7
references: 18567252
references: Dev Psychol. 2006 Nov;42(6):1089-102
references: 17087544
references: N Engl J Med. 2011 Oct 6;365(14):1346-7
references: 21991958
references: Psychol Aging. 2009 Dec;24(4):968-80
references: 20025410
references: Cereb Cortex. 2011 Dec;21(12):2809-19
references: 21527784
references: J Neurosci. 2011 Jan 19;31(3):1128-38
references: 21248137
references: J Vis. 2011 Dec 01;11(14):
references: 22135378
references: J Neurosci. 2011 Jun 8;31(23):8502-11
references: 21653854
references: Psychol Aging. 2013 Mar;28(1):77-86
references: 23066799
references: Percept Psychophys. 1988 Oct;44(4):369-78
references: 3226885
references: Nature. 1997 Nov 20;390(6657):279-81
references: 9384378
references: Neuroimage. 2012 Jan 2;59(1):646-54
references: 21763439
references: Behav Brain Sci. 2001 Feb;24(1):87-114; discussion 114-85
references: 11515286
references: Brain Res Cogn Brain Res. 2000 Sep;10(1-2):197-206
references: 10978709
references: Nature. 2008 May 8;453(7192):233-5
references: 18385672
references: J Vis. 2011 Sep 12;11(10):
references: 21911739
references: J Exp Psychol Hum Percept Perform. 1990 May;16(2):332-50
references: 2142203
references: Philos Trans R Soc Lond B Biol Sci. 1998 Aug 29;353(1373):1295-306
references: 9770223
references: Vision Res. 2004;44(14):1707-16
references: 15136005
references: Psychol Aging. 2004 Sep;19(3):541-6
references: 15383004
references: Curr Aging Sci. 2009 Mar;2(1):43-59
references: 20021398
references: Q J Exp Psychol (Hove). 2008 May;61(5):674-82
references: 18421642
references: Dev Sci. 2012 Jul;15(4):528-39
references: 22709402
references: Nature. 2011 Jul 27;476(7359):210-3
references: 21796118
references: Psychol Aging. 2012 Sep;27(3):627-37
references: 22563939
references: J Exp Psychol Gen. 2002 Mar;131(1):48-64
references: 11900102
references: J Exp Psychol Hum Percept Perform. 2001 Feb;27(1):92-114
references: 11248943
references: Neurosci Lett. 2009 Jan 2;449(1):1-5
references: 18977410
references: Psychol Aging. 2010 Dec;25(4):968-79
references: 20973605
references: Brain. 2009 Apr;132(Pt 4):1057-66
references: 19293236
references: J Vis. 2010 Dec 06;10(14):8
references: 21135255
references: Psychol Aging. 1989 Dec;4(4):500-3
references: 2619956
references: J Vis. 2012 Mar 14;12(3):
references: 22419756
references: Neuropsychologia. 2011 May;49(6):1622-31
references: 21172364
references: J Vis. 2012 Apr 20;12(4):
references: 22523399
references: Curr Biol. 2011 Jun 7;21(11):975-9
references: 21596568
references: Mem Cognit. 1996 Jul;24(4):403-16
references: 8757490
references: Psychol Aging. 2004 Jun;19(2):310-7
references: 15222824