title: Ceriponols A-K, tremulane sesquitepenes from Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte of Huperzia serrata.
abstract: Tremulane sesquiterpenes ceriponols A-K, together with three known ones tremulenediol A, 11,12-dihydroxy-1-tremulen-5-one and conocenol B, were isolated from the cultures of Ceriporia lacerate, a fungal endophyte residing in the stems of the medicinal plant Huperzia serrata. Among these isolates, ceriponol B possessed an unprecedent 12-nortremulane skeleton. The structures of all isolates were elucidated by spectroscopic methods, including MS and NMR (1D and 2D) spectroscopic techniques. The cytotoxic activities of ceriponols A-K were evaluated against three human tumor cell lines (HeLa, HepG2, and SGC 7901). Ceriponols F and K exhibited moderate cytotoxicity against all the tested human cancer cell lines with IC50 values ranging from 32.3 ± 0.4 to 173.2 ± 1.5 μM, while ceriponol G showed slightly better cytotoxicity against a HeLa cell line.
authors: College of Pharmaceutical Science Zhejiang University of Technology, People's Republic of China.
authors: You-Min
authors: YM
authors: Ying
authors: Wei-Guang
authors: WG
authors: Shan
authors: Li-Wen
authors: LW
authors: Zhang
authors: Zha-Jun
authors: ZJ
authors: Zhan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D060026:Endophytes / Q000737:chemistry; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D032501:Huperzia / Q000382:microbiology*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D020072:Polyporales / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D012717:Sesquiterpenes; C588393:ceriponol F; C588394:ceriponol K
keywords: Ceriporia lacerate; Endophytes; Huperzia serrata; Lycopodiopsida; Nor-sesquiterpenes; Polyporaceae; Sesquiterpenes; Tremulane