title: Antioxidant and anti-fatigue activities of flavonoids from Puerariae radix.
abstract: This study evaluated the antioxidant and anti-fatigue activities of flavonoids from Puerariae radix (FPR). In vitro antioxidant activities of FPR were investigated through hydroxyl and superoxide radical scavenging activities. In vivo anti-fatigue activity of FPR was investigated through loaded swimming exercise of mice. Results showed that FPR had not only in vitro antioxidant activities, but also an in vivo anti-fatigue activity in mice. FPR possessed superoxide and hydroxyl radical scavenging activity in in vitro experimental studies. In vivo experimental studies, FPR could evidently extend exhaustive swimming time of mice, inhibit the increase of blood lactic acid (BLA), decrease serum urea nitrogen (BUN) and malondialdehyde (MDA) contents, promote increases in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) of mice after swimming. The results provided an important basis for developing the FPR as a novel antioxidant and anti-fatigue compound.
authors: Sichuan Normal University, Chengdu, No.5, Jin'An Road, 610068, P.R. China. waximi41@hotmail.com
authors: Wang
authors: W
authors: Xiaoming
authors: Lei
authors: L
authors: Ling
authors: Zhang
authors: Z
authors: Jinghang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005221:Fatigue / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008813:Mice, Inbred ICR; D010807:Physical Endurance / Q000187:drug effects*; D008517:Phytotherapy; D018517:Plant Roots; D029908:Pueraria / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013550:Swimming
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D013481:Superoxides; D017665:Hydroxyl Radical; D019344:Lactic Acid; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Puerariae radix; anti-fatigue; antioxidant; flavonoids
references: Mol Aspects Med. 2002 Feb-Jun;23(1-3):101-208
references: 12079771
references: Life Sci. 2006 Jun 20;79(4):324-30
references: 16472823
references: Indian J Pharmacol. 2009 Apr;41(2):64-7
references: 20336219
references: Physiol Rev. 2008 Jan;88(1):287-332
references: 18195089
references: Ann Nutr Metab. 2006;50(4):380-6
references: 16809907
references: J Sports Sci. 2010 Oct;28(12):1261-8
references: 20845212
references: J Ethnopharmacol. 2004 Jul;93(1):75-81
references: 15182908
references: Int J Sport Nutr Exerc Metab. 2010 Feb;20(1):2-14
references: 20190346
references: Physiol Rev. 2008 Oct;88(4):1243-76
references: 18923182
references: Nutrition. 2008 Apr;24(4):293-9
references: 18272335
references: Biol Pharm Bull. 2006 May;29(5):962-6
references: 16651727
references: J Agric Food Chem. 2000 Aug;48(8):3597-604
references: 10956156
references: J Bone Miner Metab. 2003;21(5):268-75
references: 12928827
references: J Agric Food Chem. 2011 Jul 27;59(14):7948-53
references: 21675717
references: Nutrients. 2010 Mar;2(3):319-29
references: 22254024
references: Appl Microbiol Biotechnol. 2006 Mar;70(2):247-53
references: 15983804
references: Clin Biochem. 2007 Jan;40(1-2):141-2
references: 17123499
references: Med Sci Sports. 1970 Summer;2(2):51-78
references: 4939286
references: Life Sci. 2010 Jan 2;86(1-2):39-44
references: 19913560
references: J Appl Physiol (1985). 1996 Oct;81(4):1843-9
references: 8904607
references: Life Sci. 2005 Nov 4;77(25):3183-96
references: 16005472