title: Comparison of serum from gastric cancer patients and from healthy persons using FTIR spectroscopy.
abstract: Since serum can reflect human beings' physiological and pathological conditions, FTIR spectroscopy was used to compare gastric cancer patients' serum with healthy persons' serum in this study. The H2959/H2931, H1646/H1550, H1314/H1243, H1453/H1400 and H1080/H1550 ratios were calculated, among these ratios, the H2959/H2931 ratio might be a standard for distinguishing gastric cancer patients from healthy persons. Then curve fitting was processed using Gaussian curves in the 1140-1000 cm(-1) region, and the result showed that the RNA/DNA ratios of gastric cancer patients' serum were obviously lower than those of healthy persons' serum. The results suggest that FTIR spectroscopy may be a potentially useful tool for diagnosis of gastric cancer.
authors: School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China; The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
authors: Daping
authors: D
authors: Sheng
authors: Yican
authors: Y
authors: Wu
authors: Xin
authors: X
authors: Wang
authors: Dake
authors: D
authors: Huang
authors: Xianliang
authors: X
authors: Chen
authors: Xingcun
authors: X
authors: Liu
mesh_terms: D000328:Adult; D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000097:blood*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D012313:RNA; D004247:DNA
keywords: Curve fitting; FTIR; FTIR spectroscopy; Fourier transform infrared; Gastric cancer patients; Healthy persons; IR; Serum; infrared