title: Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate) copolymer.
abstract: BACKGROUND
  Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo.
  
  
  METHODS
  Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells.
  
  
  RESULTS
  Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model.
  
  
  CONCLUSIONS
  We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system.
authors: Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea.
authors: Kyung Dong
authors: KD
authors: Lee
authors: Young-Il
authors: YI
authors: Jeong
authors: Da Hye
authors: DH
authors: Kim
authors: Gyun-Taek
authors: GT
authors: Lim
authors: Ki-Choon
authors: KC
authors: Choi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000473:pathology; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C507106:poly(acrylic acid-co-methyl methacrylate); D002945:Cisplatin
keywords: cisplatin; ion complexes; nanoparticle; poly(acrylic acid-co-methyl methacrylate)
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