title: Pd(II)-catalyzed intramolecular 1,2-aminoalkylation of conjugated 1,3-dienes for the synthesis of pyrrolizidines.
abstract: A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.
authors: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors: Dong
authors: D
authors: Xing
authors: Dan
authors: D
authors: Yang
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D000577:Amides; D011763:Pyrrolizidine Alkaloids; D010165:Palladium