title: Tranexamic acid accelerates skin barrier recovery and upregulates occludin in damaged skin.
abstract: BACKGROUND
  Tranexamic acid (TA) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become the topic of a lot of research. The aim of this study is to determine whether TA could repair the skin barrier by means of tight intercellular junctions.
  
  
  METHODS
  Two kinds of damaged skin models were set up and subjected to repeated application of sodium lauryl sulfate and irradiation of ultraviolet B. Through bioengineering technology and immunohistochemistry tests, TA-induced changes in skin were detected.
  
  
  RESULTS
  After 1, 3, 7, and 14 days of application, TA can significantly accelerate barrier recovery and decrease the melanin index values of ultraviolet B irritation skin. The mean optic density of occludin from TA treatment is higher than from self-repair.
  
  
  CONCLUSIONS
  These experiments suggest that TA can accelerate skin barrier recovery and upregulate occludin induced by physicochemical damages of human skin, but it is advisable to perform more research on the upregulation of occludin in molecular mechanism in the future.
authors: Department of Skin & Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, China.
authors: Chao
authors: C
authors: Yuan
authors: Xue-Min
authors: XM
authors: Wang
authors: Li-Jie
authors: LJ
authors: Yang
authors: Pei-Lan
authors: PL
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008543:Melanins / Q000032:analysis; D008875:Middle Aged; D062793:Occludin / Q000032:analysis; D011832:Radiation Injuries / Q000188:drug therapy / Q000209:etiology; D012867:Skin / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D019108:Tight Junctions / Q000187:drug effects; D014148:Tranexamic Acid / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects; D015854:Up-Regulation / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D008543:Melanins; D062793:Occludin; D012967:Sodium Dodecyl Sulfate; D014148:Tranexamic Acid