title: Interaction between a regenerative matrix and wound bed in nonhealing ulcers: results with 16 cases.
abstract: A chronic wound is a wound that is delayed in one of the wound-healing stages and cannot progress any further. A chronic wound leaves the patient at risk of infection and hospitalization. In these case series, 16 patients affected by venous ulcers underwent Hyalomatrix PA grafting for reconstructive surgery. Hyalomatrix PA is a bilayered, sterile, flexible, and conformable three-dimensional matrix made of fibers of HYAFF, a benzyl ester of hyaluronic acid, and a semipermeable silicone membrane. Hyalomatrix PA acts as a substitutive and regenerative permanent matrix able to replace the dermis providing a three-dimensional matrix for cellular invasion and capillary growth. The silicon layer controls water vapor loss avoiding an excessive loss of fluids and acts as a semipermeable barrier to the external agents. In the presented cases, the average area grafted per procedure was 153 cm(2). The length of followup ranged from 0.5 to 1 year. The final results were considered to be good in 12 cases, fair in 3 cases, and poor in one case. This study suggests that the combination of wound bed preparation with application of the hyaluronic regenerative matrix can be a valid approach for treatment of partial thickness ulcers.
authors: Department of Dermatology, Macchi Foundation Hospital, Varese, Italy. alberico.motolese@ospedale.varese.it
authors: Alberico
authors: A
authors: Motolese
authors: Francesca
authors: F
authors: Vignati
authors: Roberto
authors: R
authors: Brambilla
authors: Michele
authors: M
authors: Cerati
authors: Alberto
authors: A
authors: Passi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D002908:Chronic Disease / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000175:diagnosis* / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D006820:Hyaluronic Acid
references: J Burn Care Res. 2007 Mar-Apr;28(2):269-74
references: 17351444
references: Biomaterials. 2000 Nov;21(21):2183-91
references: 10985492
references: Physiol Rev. 2011 Jan;91(1):221-64
references: 21248167
references: J Vasc Surg. 1998 Nov;28(5):876-83
references: 9808856
references: Clin Dermatol. 2005 Jul-Aug;23(4):388-95
references: 16023934
references: J Invest Dermatol. 1998 Mar;110(3):292-6
references: 9506452
references: Exp Cell Res. 2004 Jun 10;296(2):123-34
references: 15149843
references: J Invest Dermatol. 1998 Nov;111(5):850-7
references: 9804349
references: Eur J Vasc Endovasc Surg. 2004 Nov;28(5):484-93
references: 15465369
references: Wound Repair Regen. 1996 Apr-Jun;4(2):234-9
references: 17177819
references: Wound Repair Regen. 1996 Jul-Sep;4(3):321-5
references: 17177727
references: Wound Repair Regen. 1999 Mar-Apr;7(2):79-89
references: 10231509
references: Tissue Eng. 2006 Oct;12(10):2985-95
references: 17518666
references: Wounds. 2011 Aug;23(8):228-35
references: 25879233
references: Lancet. 1993 Apr 17;341(8851):1006-8
references: 7682272
references: Br J Nurs. 2004 Aug 12-Sep 8;13(15):S16-23
references: 15365480