title: Helical foldamer containing a combination of cyclopentane-1,2-diamine and 2,2-dimethylmalonic acid.
abstract: We have developed new helical oligomers using a combination of (1S,2S)-cyclopentane-1,2-diamine [(S,S)-CPDA] and 2,2-dimethylmalonic acid (DMM) residues as building blocks. In solution, the preferred secondary structure of the (S,S) tetramer 6 was a right-handed (P) helix, and that of the (R,R) tetramer ent-6 was a left-handed (M) helix. In the crystalline state, both 6 and the (S,S) pentamer 7 folded into (P) 11-helices, and ent-6 folded into an (M) 11-helix with hydrogen bonds that were oriented in alternating directions.
authors: Division of Organic Chemistry, National Institute of Health Sciences , Tokyo 158-8501, Japan.
authors: Norikazu
authors: N
authors: Yamazaki
authors: Yosuke
authors: Y
authors: Demizu
authors: Yukiko
authors: Y
authors: Sato
authors: Mitsunobu
authors: M
authors: Doi
authors: Masaaki
authors: M
authors: Kurihara
mesh_terms: D003517:Cyclopentanes / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry*; D006860:Hydrogen Bonding; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D012996:Solutions
chemical_list: D003517:Cyclopentanes; D003959:Diamines; D008314:Malonates; D012996:Solutions; C467768:cyclopentane-1,2-diamine; C087784:2,2-dimethylmalonic acid