title: Trends in the susceptibility of methicillin-resistant Staphylococcus aureus to nine antimicrobial agents, including ceftobiprole, nemonoxacin, and tyrothricin: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006-2010.
abstract: This study investigated the in vitro susceptibilities of methicillin-resistant Staphylococcus aureus (MRSA) to nine antimicrobial agents in Taiwan. A total of 1,725 isolates were obtained from 20 hospitals throughout Taiwan from 2006 to 2010. The minimum inhibitory concentrations (MICs) of the nine agents were determined by the agar dilution method. The MICs of mupirocin and tyrothricin were determined for 223 MRSA isolates collected from 2009 to 2010. For vancomycin, 99.7 % were susceptible; however, 30.0 % (n = 517) exhibited MICs of 2 μg/ml and 0.3 % (n = 6) demonstrated intermediate susceptibility (MICs of 4 μg/ml). Nearly all isolates (≥ 99.9 %) were susceptible to teicoplanin, linezolid, and daptomycin. The MIC90 values were 2 μg/ml for ceftobiprole and 1 μg/ml for nemonoxacin. The MIC90 values of mupirocin and tyrothricin were 0.12 and 4 μg/ml, respectively. MIC creep was noted for daptomycin during this period, but not for vancomycin, teicoplanin, linezolid, or tigecycline. For isolates with vancomycin MICs of 2 μg/ml, the MIC90 values were 2 μg/ml for teicoplanin, 0.5 μg/ml for daptomycin, and 0.5 μg/ml for tigecycline. Those values were four- to eight-fold higher than those among isolates with vancomycin MICs of 0.5 μg/ml (2, 0.06, and 0.12 μg/ml, respectively). Of the nine MRSA isolates exhibiting non-susceptibility to vancomycin (n = 6), teicoplanin (n = 1), daptomycin (n = 2), or tigecycline (n = 1), all had different pulsotypes, indicating the absence of intra-hospital or inter-hospital spread. The presence of a high proportion of MRSA isolates with elevated MICs (2 μg/ml) and MIC creep of daptomycin might alert clinicians on the therapy for serious MRSA infections in Taiwan.
authors: Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Y-H
authors: YH
authors: Chen
authors: C-Y
authors: CY
authors: Liu
authors: W-C
authors: WC
authors: Ko
authors: C-H
authors: CH
authors: Liao
authors: P-L
authors: PL
authors: Lu
authors: C-H
authors: CH
authors: Huang
authors: C-T
authors: CT
authors: Lu
authors: Y-C
authors: YC
authors: Chuang
authors: S-M
authors: SM
authors: Tsao
authors: Y-S
authors: YS
authors: Chen
authors: Y-C
authors: YC
authors: Liu
authors: W-Y
authors: WY
authors: Chen
authors: T-N
authors: TN
authors: Jang
authors: H-C
authors: HC
authors: Lin
authors: C-M
authors: CM
authors: Chen
authors: Z-Y
authors: ZY
authors: Shi
authors: S-C
authors: SC
authors: Pan
authors: J-L
authors: JL
authors: Yang
authors: H-C
authors: HC
authors: Kung
authors: C-E
authors: CE
authors: Liu
authors: Y-J
authors: YJ
authors: Cheng
authors: J-W
authors: JW
authors: Liu
authors: W
authors: W
authors: Sun
authors: L-S
authors: LS
authors: Wang
authors: K-W
authors: KW
authors: Yu
authors: P-C
authors: PC
authors: Chiang
authors: M-H
authors: MH
authors: Lee
authors: C-M
authors: CM
authors: Lee
authors: G-J
authors: GJ
authors: Hsu
authors: P-R
authors: PR
authors: Hsueh
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D062665:Epidemiological Monitoring; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology; D013624:Taiwan; D014449:Tyrothricin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015363:Quinolones; D014449:Tyrothricin; C443755:ceftobiprole; C543520:nemonoxacin
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