title: Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers.
abstract: Apigenin, a natural phytoestrogen flavonoid, has potential biological effects, including antioxidative, anti-inﬂammatory and anticancer activities. The mechanisms of anticancer activities of apigenin are unknown. Some studies have found that apigenin inhibits GLUT-1 mRNA and protein expression in cancer cells. Thus, we hypothesized that apigenin exerts similar effects on head and neck cancers through its inhibition of GLUT-1 expression. In this article, we review the anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. In addition, we describe the current state of knowledge about the relationship between apigenin and GLUT-1 expression in head and neck cancers.
authors: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou City, Zhejiang Province, China.
authors: Yang-Yang
authors: YY
authors: Bao
authors: Shui-Hong
authors: SH
authors: Zhou
authors: Jun
authors: J
authors: Fan
authors: Qin-Ying
authors: QY
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D047310:Apigenin / Q000627:therapeutic use*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D051272:Glucose Transporter Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D051272:Glucose Transporter Type 1; D047310:Apigenin