title: Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses.
abstract: There is a need for both new and improved vaccination formulations for a range of diseases for which current vaccines are either inadequate or non-existent. Biodegradable polymer-based vaccines fulfill many of the desired properties in achieving effective long-term protection in a manner that is safe, economical, and potentially more practicable on a global scale. Here we discuss some of the work performed with micro/nanoparticles made from either synthetic (poly[lactic-co-glycolic acid] [PLGA] and polyanhydrides) or natural (chitosan) biodegradable polymers. Our attention is focused on, but not limited to, the generation of antitumor immunity where we stress the importance of particle size and co-delivery of antigen and adjuvant.
authors: Department of Pharmaceutical Sciences and Experimental Therapeutics; College of Pharmacy; University of Iowa; Iowa City, IA USA.
authors: Vijaya B
authors: VB
authors: Joshi
authors: Department of Pharmaceutical Sciences and Experimental Therapeutics; College of Pharmacy; University of Iowa; Iowa City, IA USA.
authors: Sean M
authors: SM
authors: Geary
authors: Department of Pharmaceutical Sciences and Experimental Therapeutics; College of Pharmacy; University of Iowa; Iowa City, IA USA.
authors: Aliasger K
authors: AK
authors: Salem
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D063566:Biodegradable Plastics / Q000494:pharmacology*; D004337:Drug Carriers / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular; D053758:Nanoparticles; D052638:Particulate Matter / Q000494:pharmacology*; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000941:Antigens; D063566:Biodegradable Plastics; D004337:Drug Carriers; D052638:Particulate Matter; D014612:Vaccines
keywords: PLGA; adjuvant; biodegradable polymer; cancer vaccine; chitosan; polyanhydride
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