title: IGF-I levels and visceral fat accumulation in colonic neoplasia.
abstract: BACKGROUND
  IGF-I, visceral obesity, IGF binding protein-3 and insulin are reported to be potential risk factors for colorectal carcinogenesis. Many studies report a relation between obesity, insulin resistance and the risk of colon cancer. This study investigates the association between IGF-I levels, insulin resistance and visceral fat accumulation in patients with colon cancer and adenoma.
  
  
  METHODS
  In this cross sectional study, 48 sequential patients were diagnosed with either colorectal adenoma or carcinoma were enrolled. The control subjects were 30 sequential subjects. Serum IGF-I, HOMA insulin resistance index and visceral fat were measured in patients with colorectal adenoma and carcinoma.
  
  
  RESULTS
  Serum IGF-I levels were significantly higher in patients with colorectal adenoma and carcinoma compared with controls. Visceral fat accumulation was lower in colorectal carcinoma group compared with colorectal adenoma group, but no statistically significant difference was observed among them and controls. No statistically significant difference was observed in HOMA insulin resistance index, fasting insulin and fasting glucose concentrations among the three groups. No correlation was found between insulin resistance and serum IGF-I levels and visceral fat accumulation. Logistic regression analysis showed that plasma IGF-I concentration was significantly associated with colorectal adenoma and carcinoma. Body mass index and waist circumference were associated with colorectal, carcinoma but were not associated with adenoma.
  
  
  CONCLUSIONS
  In our study we found that, IGF-I levels are associated with colorectal adenomas and carcinomas, independent of insulin resistance and visceral fat accumulation; supporting the hypothesis that an increase in IGF-I levels may be a factor involved in the development of colon cancer.
authors: Dışkapı Yıldırım Beyazıt Education and Research Hospital, Department of Gastroenterology, İrfan Baştuğ Caddesi, 06110 Ankara, Turkey. Electronic address: elifeerarslan@gmail.com.
authors: Elife
authors: E
authors: Erarslan
authors: Dışkapı Yıldırım Beyazıt Education and Research Hospital, Department of Gastroenterology, İrfan Baştuğ Caddesi, 06110 Ankara, Turkey.
authors: Yusuf
authors: Y
authors: Coşkun
authors: Fatih University, School of Medicine, Department of Gastroenterology, Ankara, Turkey.
authors: Cansel
authors: C
authors: Türkay
authors: Fatih University, School of Medicine, Department of Radiology, Ankara, Turkey.
authors: Aslı
authors: A
authors: Köktener
authors: Harran University, School of Medicine, Department of Gastroenterology, Şanlıurfa, Turkey.
authors: Timuçin
authors: T
authors: Aydoğan
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D050152:Intra-Abdominal Fat; D008297:Male; D008875:Middle Aged
chemical_list: D007334:Insulin-Like Growth Factor I