title: Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population.
abstract: OBJECTIVE
  To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population.
  
  
  METHODS
  Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease.
  
  
  RESULTS
  The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively].
  
  
  CONCLUSIONS
  The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide.
authors: *Miami Veterans Affairs Medical Center, Miami, FL; and †Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.
authors: Andrew J
authors: AJ
authors: McClellan
authors: Allison L
authors: AL
authors: McClellan
authors: Candido F
authors: CF
authors: Pezon
authors: Carol L
authors: CL
authors: Karp
authors: William
authors: W
authors: Feuer
authors: Anat
authors: A
authors: Galor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D016022:Case-Control Studies; D003230:Conjunctival Neoplasms / Q000453:epidemiology*; D003316:Corneal Diseases / Q000453:epidemiology*; D016208:Databases, Factual; D005134:Eye Neoplasms / Q000453:epidemiology*; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014728:Veterans / Q000706:statistics & numerical data*
references: Arch Ophthalmol. 2002 May;120(5):554-8
references: 12003603
references: Cancer. 1967 Oct;20(10):1689-98
references: 6058176
references: Ophthalmology. 1997 Mar;104(3):485-92
references: 9082277
references: Cancer. 2001 Apr 15;91(8 Suppl):1603-6
references: 11309758
references: Health Serv Res. 2005 Oct;40(5 Pt 2):1573-83
references: 16178996
references: Cancer Epidemiol Biomarkers Prev. 1997 Feb;6(2):73-7
references: 9037556
references: Arch Ophthalmol. 1992 Apr;110(4):525-7
references: 1562262
references: Br J Ophthalmol. 2006 Jan;90(1):109-13
references: 16361679
references: Cornea. 2003 Jan;22(1):1-4
references: 12502938
references: Br J Ophthalmol. 2003 Apr;87(4):396-8
references: 12642297
references: Bull Soc Belge Ophtalmol. 1998;268:135-41
references: 9810095
references: Ophthalmology. 2002 Mar;109(3):542-7
references: 11874759
references: Ophthalmic Surg. 1990 Jan;21(1):27-30
references: 2325992
references: Cornea. 2003 Oct;22(7):687-704
references: 14508267
references: Lancet. 1995 Jul 22;346(8969):257-8
references: 7616836
references: Br J Ophthalmol. 1999 Jan;83(1):98-103
references: 10209445
references: Br J Ophthalmol. 2002 Feb;86(2):168-73
references: 11815342
references: Int J Med Inform. 2003 Mar;69(2-3):135-56
references: 12810119
references: Br J Cancer. 2000 May;82(9):1585-92
references: 10789729
references: Cent Afr J Med. 2003 Jan-Feb;49(1-2):1-4
references: 14562592
references: Br J Ophthalmol. 2011 Mar;95(3):350-4
references: 20837790
references: Br J Ophthalmol. 1996 Jun;80(6):503-8
references: 8759259
references: Invest Ophthalmol Vis Sci. 1992 Jan;33(1):184-9
references: 1309728
references: Br J Cancer. 2002 Jul 29;87(3):301-8
references: 12177799