title: Uveal melanoma: Ocular and systemic disease.
abstract: Although rare, uveal melanoma is the most common intraocular tumor in adults. Most cases arise from the choroidal layer of the uvea, displaying a discoid, collar-button, or mushroom shaped growth. Histopathologically, neoplasms are classified by the dominant cell type: spindle, epithelioid or mixed spindle cell type. The most important prognostic factors are cell type, nucleolar size, largest tumor dimension, and mitotic figures. Patient prognosis is poor when metastases occur in the liver, one of the main reasons that despite advances in the diagnosis and treatment of uveal melanoma, the mortality rate has not change significantly since 1973.
authors: The Henry C. Witelson Ocular Pathology Laboratory, McGill University Health Center, Montreal, QC, Canada.
authors: Cristina
authors: C
authors: Miyamoto
authors: Matthew
authors: M
authors: Balazsi
authors: Silvin
authors: S
authors: Bakalian
authors: Bruno F
authors: BF
authors: Fernandes
authors: Miguel N
authors: MN
authors: Burnier
keywords: Cancer; Choroidal; Metastasis; Uveal melanoma
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