title: Levels of gingival crevicular metalloproteinases-8 and -9 in periodontitis.
abstract: Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The aim of this study was planned to determine the levels of GCF (gingival crevicular fluid) matrix metalloproteinase-8 (MMP-8) and metalloproteinase-9 (MMP-9) patients with periodontitis and in healthy controls. Levels of crevicular MMP-8 and -9 were determined by ELISA in subjects with healthy without any periodontal disease (n = 10) and periodontitis (n = 10). Significantly higher crevicular MMP-8 and -9 were observed in cases of periodontitis compared to healthy adults. Crevicular MMP-8 and -9 may serve as biomarkers of periodontal disease and aid in early detection of periodontitis.
authors: Oral Imaging center, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium.
authors: Balwant
authors: B
authors: Rai
authors: Jasdeep
authors: J
authors: Kaur
authors: Rajnish
authors: R
authors: Jain
authors: Suresh C
authors: SC
authors: Anand
keywords: Biomarkers; Metalloproteinase; Periodontal disease
references: J Clin Periodontol. 2008 Dec;35(12):1027-31
references: 19040578
references: J Periodontal Res. 2002 Jun;37(3):196-203
references: 12113554
references: J Periodontol. 2000 Mar;71(3):353-60
references: 10776921
references: Clin Chim Acta. 2000 Feb 15;291(2):223-34
references: 10675725
references: J Dent Res. 1994 Aug;73(8):1397-406
references: 8083435
references: J Clin Periodontol. 2001 Apr;28(4):353-9
references: 11314892
references: Ann N Y Acad Sci. 1993 Sep 20;694:72-7
references: 8215087
references: Microbiology (Reading). 2003 Jan;149(Pt 1):67-75
references: 12576581
references: Quintessence Int. 2007 Mar;38(3):247-52
references: 17334003
references: Inflammation. 2009 Apr;32(2):130-7
references: 19238528
references: Ann N Y Acad Sci. 1994 Sep 6;732:459-61
references: 7978839
references: J Am Dent Assoc. 2006 Mar;137(3):322-9
references: 16570465
references: Periodontol 2000. 2001;25:8-20
references: 11155179
references: J Clin Periodontol. 2001 Aug;28(8):782-9
references: 11442739
references: J Periodontol. 2006 Dec;77(12):2063-9
references: 17209792
references: J Periodontal Res. 1990 Sep;25(5):257-67
references: 2170617
references: FASEB J. 1991 May;5(8):2145-54
references: 1850705
references: J Periodontal Res. 1987 Sep;22(5):381-9
references: 2826747
references: Arch Oral Biol. 1990;35 Suppl:193S-196S
references: 1965117
references: J Periodontol. 2002 Jul;73(7):762-9
references: 12146536