title: Meta-analysis of the correlation between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus.
abstract: In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.
authors: People's Hospital of Zhengzhou, Zhengzhou, China. shilipu@126.com
authors: Lipu
authors: L
authors: Shi
authors: Yanlin
authors: Y
authors: Wei
authors: Wen
authors: W
authors: Xun
authors: Dan
authors: D
authors: Han
mesh_terms: D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: 1858C/T polymorphism; PTPN22 gene; meta-analysis; systemic lupus erythematosus (SLE)