title: Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence.
abstract: There are well-established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited but growing literature based on human studies, has demonstrated that DNA methylation (DNAm) changes occur in response to environmental stress, with some of these occurring in a sex-specific manner. In this review, we explore whether DNAm plays a role in contributing to the observed sex differences in prevalence of mental disorders in which stress contributes significantly to their etiologies, specifically posttraumatic stress disorder (PTSD) and depression. We propose that investigating sex differences in DNAm among genes known to influence brain development may help to shed light on the sexually dimorphic risk for, or resilience to, developing PTSD and depression.
authors: Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, Michigan; Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan.
authors: Monica
authors: M
authors: Uddin
authors: Levent
authors: L
authors: Sipahi
authors: Jia
authors: J
authors: Li
authors: Karestan C
authors: KC
authors: Koenen
mesh_terms: D019175:DNA Methylation / Q000502:physiology*; D003866:Depressive Disorder / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D055500:Resilience, Psychological; D012306:Risk; D012737:Sex Factors; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics
keywords: DNA methylation; sex; stress
references: Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):700-8
references: 21714072
references: Neuroendocrinology. 2011;93(3):150-8
references: 21411982
references: Nat Neurosci. 2009 Mar;12(3):342-8
references: 19234457
references: Neuroscientist. 2002 Oct;8(5):497-511
references: 12374432
references: Epigenetics. 2008 Mar-Apr;3(2):97-106
references: 18536531
references: Psychol Med. 2011 May;41(5):997-1007
references: 20836906
references: Hum Mol Genet. 2012 Apr 15;21(8):1673-80
references: 22186023
references: Front Behav Neurosci. 2013 Apr 10;7:30
references: 23596403
references: Am J Psychiatry. 1999 Jun;156(6):816-28
references: 10360118
references: Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):101-5
references: 16958039
references: PLoS One. 2012;7(6):e39501
references: 22745770
references: Biol Psychiatry. 2009 May 1;65(9):760-9
references: 19150054
references: Arch Gen Psychiatry. 1995 Dec;52(12):1048-60
references: 7492257
references: Am J Hum Genet. 2008 Mar;82(3):696-711
references: 18319075
references: Psychol Med. 1980 Nov;10(4):633-45
references: 7208723
references: Nat Neurosci. 2009 Dec;12(12):1559-66
references: 19898468
references: Mol Neurobiol. 2004 Dec;30(3):307-25
references: 15655254
references: J Am Acad Child Adolesc Psychiatry. 2003 Mar;42(3):269-78
references: 12595779
references: JAMA. 2008 Mar 19;299(11):1345-50
references: 18349095
references: Nat Protoc. 2009;4(1):44-57
references: 19131956
references: Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):543-9
references: 17987668
references: Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5169-74
references: 23487789
references: Biol Psychiatry. 2010 Sep 1;68(5):405-7
references: 20591416
references: Depress Anxiety. 2011 Aug;28(8):639-47
references: 21608084
references: Horm Behav. 2011 Mar;59(3):338-44
references: 20800064
references: Epigenetics. 2011 Jul;6(7):857-61
references: 21617370
references: Pediatr Res. 2009 Jun;65(6):591-8
references: 19218885
references: Endocrinology. 2010 May;151(5):2297-305
references: 20237133
references: Epigenetics. 2009 Jan;4(1):47-53
references: 19029819
references: J Neurosci. 2009 Oct 14;29(41):12815-23
references: 19828794
references: Endocrinology. 2010 Oct;151(10):4871-81
references: 20702577
references: PLoS One. 2012;7(1):e30148
references: 22295073
references: Arch Gen Psychiatry. 1998 Jul;55(7):626-32
references: 9672053
references: Proc Natl Acad Sci U S A. 2010 May 18;107(20):9470-5
references: 20439746
references: Arch Gen Psychiatry. 1997 Nov;54(11):1044-8
references: 9366662
references: Dis Markers. 2011;30(2-3):111-21
references: 21508515
references: Autism Res. 2008 Jun;1(3):169-78
references: 19132145
references: Arch Neurol. 1986 Jun;43(6):570-2
references: 3718283
references: Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):710-713
references: 19739105
references: Arch Gen Psychiatry. 2008 Jul;65(7):785-93
references: 18606951
references: Child Dev. 2010 Jan-Feb;81(1):41-79
references: 20331654
references: Nat Neurosci. 2013 Jan;16(1):33-41
references: 23201972
references: Genome Biol. 2012 Jun 15;13(6):R43
references: 22703893
references: Epigenetics. 2007 Sep;2(3):173-8
references: 17965589
references: J Consult Clin Psychol. 2000 Oct;68(5):748-66
references: 11068961
references: J Psychiatr Res. 2011 Jul;45(7):919-26
references: 21306736
references: Nat Neurosci. 2010 Nov;13(11):1351-3
references: 20890295
references: J Neuroendocrinol. 2011 Jul;23(7):577-83
references: 21518035
references: Am J Psychiatry. 2001 Apr;158(4):587-93
references: 11282693
references: Arch Gen Psychiatry. 1994 Jan;51(1):8-19
references: 8279933
references: Nat Neurosci. 2004 Aug;7(8):847-54
references: 15220929
references: PLoS One. 2011;6(11):e28128
references: 22132228
references: Child Dev. 2013 Jan-Feb;84(1):58-75
references: 21883162
references: Ann N Y Acad Sci. 2011 Mar;1220:49-59
references: 21388403
references: JAMA. 2008 Jun 25;299(24):2877-83
references: 18577732
references: Cell. 2007 Feb 23;128(4):669-81
references: 17320505
references: Front Psychiatry. 2012 Jun 13;3:55
references: 22707942
references: Dev Psychobiol. 2014 Apr;56(3):392-406
references: 23460384
references: J Affect Disord. 1993 Oct-Nov;29(2-3):85-96
references: 8300981
references: Biol Psychiatry. 2012 Feb 15;71(4):350-7
references: 22030358
references: Adv Exp Med Biol. 2009;651:47-57
references: 19731549
references: Nature. 2011 Feb 24;470(7335):492-7
references: 21350482
references: Endocrinology. 2006 Jun;147(6):2909-15
references: 16513834
references: Depress Anxiety. 2010 Jul;27(7):631-42
references: 20336807
references: Biochim Biophys Acta. 1984 Sep 10;782(4):331-42
references: 6383476
references: Psychol Bull. 2006 Nov;132(6):959-92
references: 17073529
references: Mol Psychiatry. 2009 Jul;14(7):728-37
references: 18283278
references: PLoS One. 2012;7(11):e48597
references: 23155396
references: Mol Cell Biol. 1999 Feb;19(2):1182-9
references: 9891052
references: Horm Behav. 2011 Mar;59(3):358-63
references: 20619265
references: Nat Genet. 2006 Dec;38(12):1378-85
references: 17072317
references: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1181-8
references: 20600466
references: Epigenomics. 2012 Feb;4(1):29-40
references: 22332656
references: Acta Psychiatr Scand. 2005 Apr;111(4):291-9
references: 15740465
references: Neuropsychopharmacology. 2013 Jan;38(1):183-97
references: 22643929
references: J Child Psychol Psychiatry. 2003 Nov;44(8):1092-115
references: 14626453