title: Enhanced potassium selectivity in a bioinspired solid nanopore.
abstract: Biological ion channels present unique ionic properties. They can be highly permeable to ions, while selecting only one type of ions, without external energy supply. An important research field has been developed to transfer these properties to solid state nanoporous membranes in order to develop artificial biomimetic nanofilters. One of the promising ways to develop biomimetic structures is based on the direct insertion of the gramicidin A, i.e. an ionic channel, inside a nanopore. Experiments have recently proved the feasibility of such a hybrid membrane with very interesting results regarding the ionic selectivity. Here, we propose to interpret these experiments using theoretical molecular dynamic simulations which allow us to analyze more profoundly the structures of the proteins confined inside the nanopore and the relation between their conformation and the observed ionic properties.
authors: Laboratoire de Nanomédecine, Imagerie et Thérapeutique, Université Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16 route de Gray, 25030 Besançon cedex, France. fabien.picaud@univ-fcomte.fr.
authors: Fabien
authors: F
authors: Picaud
authors: Sebastian
authors: S
authors: Kraszewski
authors: Christophe
authors: C
authors: Ramseyer
authors: Sébastien
authors: S
authors: Balme
authors: Philippe
authors: P
authors: Déjardin
authors: Jean Marc
authors: JM
authors: Janot
authors: François
authors: F
authors: Henn
mesh_terms: D032701:Biomimetics; D004058:Diffusion; D006096:Gramicidin / Q000737:chemistry / Q000378:metabolism; D008567:Membranes, Artificial; D056004:Molecular Dynamics Simulation; D058608:Nanopores; D011188:Potassium / Q000378:metabolism*; D011487:Protein Conformation; D055672:Static Electricity; D013379:Substrate Specificity
chemical_list: D008567:Membranes, Artificial; D006096:Gramicidin; D011188:Potassium