title: Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation.
abstract: Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction between positive surfactant micelles and negative polypeptides. Core-shell-like structures of supramolecular nanogels provide stable hydrophobic pockets that prevent simple diffusion of hydrophobic guest molecules, resulting in high encapsulation stability. The size of the supramolecular nanogels can be systematically controlled by varying the size of the surfactant micelles. Furthermore, noncovalently encapsulated dye molecules can be released in response to matrix metalloproteinases highly overexpressed in tumor tissues, potentially providing tumor-triggered targeting.
authors: Department of Chemistry, Seoul National University , Seoul 151-747, Korea.
authors: Keunsuk
authors: K
authors: Kim
authors: Boram
authors: B
authors: Bae
authors: Young Ji
authors: YJ
authors: Kang
authors: Jwa-Min
authors: JM
authors: Nam
authors: Sebyung
authors: S
authors: Kang
authors: Ja-Hyoung
authors: JH
authors: Ryu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D000080385:Nanogels; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011094:Polyethyleneimine / Q000138:chemical synthesis / Q000737:chemistry*; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D001798:Blood Proteins; D046911:Macromolecular Substances; D008823:Micelles; D000080385:Nanogels; D010455:Peptides; D013501:Surface-Active Agents; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine