title: Levodopa inhibits habit-learning in Parkinson’s disease.
abstract: Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.
authors: Hannah
authors: H
authors: Fuhrer
authors: Andreas
authors: A
authors: Kupsch
authors: Thomas D
authors: TD
authors: Hälbig
authors: Ute A
authors: UA
authors: Kopp
authors: Peter
authors: P
authors: Scherer
authors: Doreen
authors: D
authors: Gruber
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D001245:Association Learning / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects; D003463:Cues; D017753:Ecosystem; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000139:chemically induced* / Q000175:diagnosis; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
references: N Engl J Med. 2004 Dec 9;351(24):2498-508
references: 15590952
references: Neuroreport. 2004 Mar 1;15(3):539-43
references: 15094519
references: J Cogn Neurosci. 2005 Jan;17(1):51-72
references: 15701239
references: Mov Disord. 1999 Jul;14(4):572-84
references: 10435493
references: Science. 2004 Dec 10;306(5703):1940-3
references: 15528409
references: Neuropsychologia. 2010 Mar;48(4):1096-103
references: 20006629
references: Neurology. 1992 Jun;42(6):1142-6
references: 1603339
references: Science. 1996 Sep 6;273(5280):1399-402
references: 8703077
references: J Neurol. 1997 Jan;244(1):2-8
references: 9007738
references: Biol Psychiatry. 2011 Jun 15;69(12):e113-25
references: 21531388
references: Cereb Cortex. 2001 Dec;11(12):1136-43
references: 11709484