title: HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection.
abstract: OBJECTIVE
  To characterize high mobility group box chromosomal protein 1 (HMGB1) polymorphisms in patients infected with hepatitis B virus (HBV) and determine the different patterns in patient subgroups.
  
  
  METHODS
  A total of 1495 unrelated Han Chinese HBV carriers were recruited in this hospital-based case-control study. The HMGB1 1176 G/C polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism assay.
  
  
  RESULTS
  A significant association was observed between HMGB1 1176 G/C polymorphism and outcome of HBV infection. The subjects bearing 1176G/G genotype had an increased risk of susceptibility to chronic hepatitis B, liver cirrhosis and severe hepatitis B when compared with those bearing at least one 1176C allele.
  
  
  CONCLUSIONS
  Patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in HBV infection.
authors: Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors: Chun-Qing
authors: CQ
authors: Deng
authors: Guo-Hong
authors: GH
authors: Deng
authors: Yu-Ming
authors: YM
authors: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D024243:HMGB1 Protein / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D024243:HMGB1 Protein; C585491:HMGB1 protein, human
keywords: Hepatitis B virus; High mobility group box chromosomal protein 1; Intron; Polymorphism
references: Cytokine. 2003 Dec 21;24(6):254-65
references: 14609567
references: Science. 1998 Oct 23;282(5389):682-9
references: 9784121
references: Best Pract Res Clin Anaesthesiol. 2004 Sep;18(3):455-75
references: 15212339
references: Nucleic Acids Res. 1988 Feb 11;16(3):1215
references: 3344216
references: Biol Blood Marrow Transplant. 2010 Feb;16(2):239-52
references: 19819342
references: Science. 1997 Dec 19;278(5346):2046-8
references: 9432713
references: Infect Genet Evol. 2012 Aug;12(6):1222-8
references: 22543033
references: Hepatology. 2004 Apr;39(4):978-88
references: 15057902
references: Intervirology. 2005;48(2-3):133-7
references: 15812186
references: Am J Gastroenterol. 2002 Aug;97(8):2086-92
references: 12190181
references: Tissue Antigens. 2007 Aug;70(2):151-6
references: 17610420
references: J Virol. 2005 Aug;79(15):9896-903
references: 16014950
references: J Hepatol. 2001 Jun;34(6):922-9
references: 11451178
references: Gene Expr Patterns. 2003 Mar;3(1):29-33
references: 12609598
references: Trends Immunol. 2005 Jul;26(7):381-7
references: 15978523
references: Crit Care. 2008;12(3):R83
references: 18577209
references: Intervirology. 2005;48(2-3):112-9
references: 15812183
references: Mutat Res. 2003 Jan 28;522(1-2):119-25
references: 12517417
references: Lancet. 2002 Sep 28;360(9338):991-5
references: 12383669
references: Gastroenterology. 2008 Mar;134(3):716-26
references: 18325387
references: Clin Exp Immunol. 1998 Mar;111(3):579-82
references: 9528902
references: Surgery. 2012 Mar;151(3):427-36
references: 22047946
references: Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):139-42
references: 15928582
references: J Viral Hepat. 2009 Nov;16(11):775-83
references: 19413695
references: Hum Mutat. 2011 Oct;32(10):1128-36
references: 21837769
references: Hepatology. 2004 Aug;40(2):318-26
references: 15368436
references: Mol Immunol. 2005 Feb;42(4):433-44
references: 15607795