title: Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple-vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2.
abstract: OBJECTIVE
  We sought to investigate medium-term outcome of percutaneous coronary intervention (PCI) compared with coronary artery bypass grafting (CABG) in patients with triple-vessel coronary artery disease (TVD).
  
  
  RESULTS
  We identified 2,981 patients with TVD (PCI: N=1,825, CABG: N=1,156) among 15,939 patients with first coronary revascularisation enrolled in the CREDO-Kyoto PCI/CABG registry cohort-2. Excess adjusted three-year risk of the PCI group relative to the CABG group for death/myocardial infarction (MI)/stroke was significant (HR 1.47 [95% CI: 1.13-1.92, p=0.004]). Adjusted risk for all-cause death was also significantly higher with PCI as compared with CABG (HR 1.62 [95% CI: 1.16-2.27, p=0.005]), while risk for cardiac death was neutral between the two groups (HR 1.3 [95% CI: 0.81-2.07, p=0.28]). PCI was also associated with a markedly higher risk for any coronary revascularisation. Regarding the analysis stratified by the SYNTAX score, the adjusted HR of PCI relative to CABG for death/MI/stroke was 1.66 (95% CI: 1.04-2.65, p=0.03) in the low-score (<23: N=874, and N=257), 1.24 (95% CI: 0.83-1.85, p=0.29) in the intermediate-score (23-32: N=638, and N=388), and 1.59 (95% CI: 0.998-2.54, p=0.051) in the high-score (≥ 33: N=280, and N=375) tertiles, respectively.
  
  
  CONCLUSIONS
  PCI as compared with CABG was associated with significantly higher risk for serious adverse events in TVD patients.
authors: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Junichi
authors: J
authors: Tazaki
authors: Hiroki
authors: H
authors: Shiomi
authors: Takeshi
authors: T
authors: Morimoto
authors: Masao
authors: M
authors: Imai
authors: Kyohei
authors: K
authors: Yamaji
authors: Ryuzo
authors: R
authors: Sakata
authors: Hitoshi
authors: H
authors: Okabayashi
authors: Michiya
authors: M
authors: Hanyu
authors: Mitsuomi
authors: M
authors: Shimamoto
authors: Noboru
authors: N
authors: Nishiwaki
authors: Tatsuhiko
authors: T
authors: Komiya
authors: Takeshi
authors: T
authors: Kimura
mesh_terms: D000368:Aged; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000379:methods; D003324:Coronary Artery Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000601:surgery; D016896:Treatment Outcome