title: Whole-genome sequencing reveals untapped genetic potential in Africa's indigenous cereal crop sorghum.
abstract: Sorghum is a food and feed cereal crop adapted to heat and drought and a staple for 500 million of the world's poorest people. Its small diploid genome and phenotypic diversity make it an ideal C4 grass model as a complement to C3 rice. Here we present high coverage (16-45 × ) resequenced genomes of 44 sorghum lines representing the primary gene pool and spanning dimensions of geographic origin, end-use and taxonomic group. We also report the first resequenced genome of S. propinquum, identifying 8 M high-quality SNPs, 1.9 M indels and specific gene loss and gain events in S. bicolor. We observe strong racial structure and a complex domestication history involving at least two distinct domestication events. These assembled genomes enable the leveraging of existing cereal functional genomics data against the novel diversity available in sorghum, providing an unmatched resource for the genetic improvement of sorghum and other grass species.
authors: 1] Department of Agriculture, Fisheries and Forestry Queensland (DAFFQ), Warwick, Queensland 4370, Australia [2].
authors: Emma S
authors: ES
authors: Mace
authors: Shuaishuai
authors: S
authors: Tai
authors: Edward K
authors: EK
authors: Gilding
authors: Yanhong
authors: Y
authors: Li
authors: Peter J
authors: PJ
authors: Prentis
authors: Lianle
authors: L
authors: Bian
authors: Bradley C
authors: BC
authors: Campbell
authors: Wushu
authors: W
authors: Hu
authors: David J
authors: DJ
authors: Innes
authors: Xuelian
authors: X
authors: Han
authors: Alan
authors: A
authors: Cruickshank
authors: Changming
authors: C
authors: Dai
authors: Céline
authors: C
authors: Frère
authors: Haikuan
authors: H
authors: Zhang
authors: Colleen H
authors: CH
authors: Hunt
authors: Xianyuan
authors: X
authors: Wang
authors: Tracey
authors: T
authors: Shatte
authors: Miao
authors: M
authors: Wang
authors: Zhe
authors: Z
authors: Su
authors: Jun
authors: J
authors: Li
authors: Xiaozhen
authors: X
authors: Lin
authors: Ian D
authors: ID
authors: Godwin
authors: David R
authors: DR
authors: Jordan
authors: Jun
authors: J
authors: Wang
mesh_terms: D000349:Africa; D018556:Crops, Agricultural / Q000235:genetics*; D002523:Edible Grain / Q000235:genetics*; D018745:Genome, Plant / Q000235:genetics*; D005838:Genotype; D015810:Linkage Disequilibrium / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D045868:Sorghum / Q000235:genetics*
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