title: Dynamic contrast-enhanced and ultra-high-resolution breast MRI at 7.0 Tesla.
abstract: OBJECTIVE
  To assess the feasibility of 7-T contrast-enhanced breast MRI in patients with suspicious masses.
  
  
  METHODS
  Twenty patients with 23 suspicious breast masses on conventional imaging (mean size 13 mm, range 5-27 mm) were examined at 7 T. The MRI protocol included a dynamic series with injection of 0.1 mmol/kg gadobutrol (seven consecutive 3D T1-weighted gradient echo sequences, resolution 1 × 1 × 2 mm(3), temporal resolution 63 s) and ultra-high-resolution imaging (T1-weighted 3D gradient echo sequence, resolution 0.45 × 0.57 × 0.45 mm(3)). Two observers (R1 and R2) independently judged the examinations on image quality and classified lesions according to BI-RADS. The added value of ultra-high-resolution imaging was assessed.
  
  
  RESULTS
  The image quality was deemed excellent in 1 and 0, good in 10 and 12, sufficient in 8 and 8, and insufficient in 1 and 0 for R1 and R2 respectively. Twenty of the 23 lesions were identified at 7-T MRI by both observers. All histopathologically proven malignant lesions (n = 19) were identified and classified as BI-RADS-MRI 4 or 5. Ultra-high-resolution imaging increased reader confidence in 88 % (R1) and 59 % (R2) of acquisitions.
  
  
  CONCLUSIONS
  The study shows the feasibility of dynamic contrast-enhanced 7-T breast MRI, where all malignant mass lesions were identified by two observers.
  
  
  CONCLUSIONS
  • Magnetic resonance imaging is important in the evaluation of breast cancer. • Recently, 7-T MRI has become available. • The 7-T dynamic contrast-enhanced breast MRI is feasible in patients. • The 7-T breast examinations are amenable to evaluation according to BI-RADS.
authors: Department of Radiology; E01.132, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands, b.l.stehouwer@umcutrecht.nl.
authors: Bertine L
authors: BL
authors: Stehouwer
authors: Dennis W J
authors: DW
authors: Klomp
authors: Maurice A A J
authors: MA
authors: van den Bosch
authors: Mies A
authors: MA
authors: Korteweg
authors: Kenneth G A
authors: KG
authors: Gilhuijs
authors: Arjen J
authors: AJ
authors: Witkamp
authors: Paul J
authors: PJ
authors: van Diest
authors: Karel A F
authors: KA
authors: Houwert
authors: Wybe J M
authors: WJ
authors: van der Kemp
authors: Peter R
authors: PR
authors: Luijten
authors: W P Th M
authors: WP
authors: Mali
authors: Wouter B
authors: WB
authors: Veldhuis
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol
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