title: Synthesis, characterization and biological studies of some novel 3-fluorosalicylaldehyde based amine derivatives.
abstract: A series of biologically important substituted 3-fluorosalicylaldehyde derivatives (1a-h) with various primary amines were synthesized by using ionic liquid (1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) as an efficient catalyst. A new series of Schiff base derivatives (1a-h) were synthesized and characterized by IR, NMR ((1)H, (13)C, (1)H-(1)H COSY and HSQC), mass spectra and elemental analysis. Further crystal structure of compound 1a was evaluated by single crystal X-ray diffraction techniques. All the synthesized compounds were screened for in vitro antimicrobial activity against a panel of selected bacterial and fungal strains using Streptomycin and Amphotericin B as standards. Most of the synthesized compounds demonstrated moderate effects on both antibacterial and antifungal activities at minimum inhibitory concentrations (MIC's).
authors: Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu 608 002, India.
authors: M
authors: M
authors: Shanmugam
authors: K
authors: K
authors: Narayanan
authors: M
authors: M
authors: Mahalakshmi
authors: S
authors: S
authors: Kabilan
authors: V
authors: V
authors: Chidambaranathan
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D054879:Halogenation; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D007094:Imides / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D013449:Sulfonamides
chemical_list: C493485:1-butyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)amide; D000447:Aldehydes; D000890:Anti-Infective Agents; D007093:Imidazoles; D007094:Imides; D052578:Ionic Liquids; D013449:Sulfonamides; C013243:salicylaldehyde
keywords: 1D-NMR; 2D-NMR spectroscopy; Antimicrobial activity; Ionic liquid; Single crystal-XRD