title: Autoimmune haemolytic anaemia in a patient treated with capecitabine.
abstract: A 61-year-old female, followed-up for a metastatic breast cancer, was admitted in our institution with conjunctival icterus, asthenia and abdominal crampoid pain. The patient was included in a clinical trial comparing the efficiency of capecitabine monotherapy versus capecitabine conjugated with a new biological agent in a randomised and double blind trial. The patient was in the capecitabine alone arm. Biological tests performed upon admission suggested the diagnosis of haemolytic anaemia. Moreover, the direct Coombs test result was twice positive indicating autoimmune haemolytic anaemia. Capecitabine has been reported to cause haemolysis either alone or combined with lapatinib, each time with a mechanism other than immunological. In this clinical case, capecitabine is the most likely factor causing an autoimmune haemolytic anaemia.
authors: Medical Oncology, Jules Bordet Institut-Université Libre de Bruxelles, Bruxelles, Belgium. sideris.spyridon@hotmail.com
authors: S
authors: S
authors: Sideris
authors: A
authors: A
authors: Loizidou
authors: A
authors: A
authors: Georgala
authors: F
authors: F
authors: Lebrun
authors: T
authors: T
authors: Gil
authors: Pr
authors: P
authors: Awada
authors: Pr
authors: P
authors: Piccart
authors: F
authors: F
authors: Cardoso
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000175:diagnosis; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil