title: Principles of miRNA-target regulation in metazoan models.
abstract: MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged.
authors: Basic Neurosciences Division, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens 11527, Greece. edoxakis@bioacademy.gr
authors: Epaminondas
authors: E
authors: Doxakis
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D026723:Polyadenylation; D034622:RNA Interference; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D035683:MicroRNAs
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