title: Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body.
abstract: Last-minute labeling: Mesoporous silica nanoparticles (MSNs) were modified with a very short half-life fluorine-18-labeled azide radiotracer by a cycloaddition reaction after the MSNs had reached the tumor site in mice. The tumor could then be visualized successfully with positron emission tomography.
authors: Department of Chemistry, Inha University, 100 Inha-ro, Nam-gu, Incheon 402-751 (Korea).
authors: Sang Bong
authors: SB
authors: Lee
authors: Hye Lan
authors: HL
authors: Kim
authors: Hwan-Jeong
authors: HJ
authors: Jeong
authors: Seok Tae
authors: ST
authors: Lim
authors: Myung-Hee
authors: MH
authors: Sohn
authors: Dong Wook
authors: DW
authors: Kim
mesh_terms: D000818:Animals; D005260:Female; D005462:Fluorine Radioisotopes / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012822:Silicon Dioxide
keywords: bioorthogonal reactions; mesoporous silica; molecular imaging; nanoparticles; radiopharmaceuticals