title: Meta-analysis on the association between the TF gene rs1049296 and AD.
abstract: BACKGROUND
  Polymorphisms of genes participating in iron transportation have been associated with Alzheimer's disease (AD) risk. The association between transferrin (TF) gene rs1049296 (P570S) polymorphism and AD is controversial.
  
  
  METHODS
  We performed meta analysis on data from 19 studies with 6310 cases and 13661 controls to reexamine the association between the TF gene rs1049296 polymorphism and AD. We applied a fixed-effects model to combine the odds ratio (OR) and 95% confidence intervals (95% CI). Egger's test was carried out to evaluate the potential publication bias.
  
  
  RESULTS
  The overall ORs with 95% CIs showed statistical association between the TF gene rs1049296 polymorphism and the risk of AD in the allele contrast, the recessive model and the dominant model for allele C2 (fixed-effects pooled OR 1.11; 95% CI 1.05 to 1.17, pooled OR 1.13; 95% CI 1.06 to 1.21, and pooled OR 1.23; 95% CI 1.03 to 1.47, respectively). In the contrast of C2C2+C2C1 vs C1C1, large heterogeneity among the Asian subgroup (p=0.041, I2= 68.6%) was observed but not among the overall population (p = 0.184, I2= 22.4%). No publication bias was observed.
  
  
  CONCLUSIONS
  The present meta analysis demonstrated that TF gene rs1049296 polymorphism is a genetic determinant of AD.
authors: Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China.
authors: Yun
authors: Y
authors: Wang
authors: Shunliang
authors: S
authors: Xu
authors: Zhen
authors: Z
authors: Liu
authors: Chao
authors: C
authors: Lai
authors: Zhaohong
authors: Z
authors: Xie
authors: Cuiping
authors: C
authors: Zhao
authors: Yan
authors: Y
authors: Wei
authors: Jian Zhong
authors: JZ
authors: Bi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000544:Alzheimer Disease / Q000235:genetics; D015982:Bias; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012306:Risk; D014168:Transferrin / Q000235:genetics
chemical_list: D014168:Transferrin