title: Prevalence, clinical features and quantification of genital non-viral infections.
abstract: We conducted a study of the prevalence, clinical features and microscopy findings, by retrospective case-notes survey, of six non-viral organisms, among 1718 attendees at a genitourinary (GU) medicine clinic in England. An in-house assay for six non-viral infections was used and quantitation of ureaplasmas performed. The prevalences of the six organisms were: Chlamydia trachomatis (CT), 7.1%; Neisseria gonorrhoeae (NG), 0.6%; Mycoplasma genitalium (MG), 1.0%; Trichomonas vaginalis, 0.2%; Ureaplasma urealyticum, 16.1%; Ureaplasma parvum, 35.6%. Among men (but not women) there were significantly raised odds ratios compared with that for U. parvum, for the symptom of discharge with CT, 7.30; MG, 6.43; NG 19.29; dysuria with CT, 5.89 and MG, 5.95; and the microscopy finding of >4 pus cells per high power field with: CT, 7.22; MG, 4.58 and NG 22.31. Evaluation of a possible link between quantitation of U. urealyticum and urethritis did not confirm research findings elsewhere.
authors: Department of Genitourinary Medicine, Clinic 1A, Box 38, Addenbrookes Hospital, Cambridge University Hospitals NHS Trust, UK. christopher.carne@addenbrookes.nhs.uk
authors: C A
authors: CA
authors: Carne
authors: J
authors: J
authors: Gibbs
authors: A
authors: A
authors: Delaney
authors: C
authors: C
authors: Sonnex
authors: N Q
authors: NQ
authors: Verlander
authors: A
authors: A
authors: Smielewska
authors: E
authors: E
authors: Skeggs
authors: N
authors: N
authors: Bentley
authors: H
authors: H
authors: Jalal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004739:England / Q000453:epidemiology; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D060737:Reproductive Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D012189:Retrospective Studies; D014247:Trichomonas Vaginitis / Q000175:diagnosis / Q000453:epidemiology*; D014246:Trichomonas vaginalis / Q000302:isolation & purification*
keywords: Mycoplasma genitalium; Ureaplasma urealyticum; clinical features; microscopy; prevalence; quantitation; sexually transmitted infections; urethritis