title: White blood cell count is positively associated with benign prostatic hyperplasia.
abstract: OBJECTIVE
  To determine whether low-grade systemic inflammation is associated with prostatic enlargement/benign prostatic hyperplasia.
  
  
  METHODS
  Prostate volume was measured by transrectal ultrasonography in 576 Japanese men. The association between prostate volume and routine clinical inflammatory markers (C-reactive protein level, white blood cell count, or the differential white cell count [neutrophils, lymphocytes, basophils, eosinophils, and monocytes]) were analyzed. Contributors to prostate volume were identified in univariate and multivariable linear regression models.
  
  
  RESULTS
  Prostate volume was found to have a positive association with serum prostate-specific antigen level (P < 0.001), white blood cell count (P = 0.027) and absolute neutrophil count (P = 0.010). In univariate linear regression models, a large prostate volume was associated with older age, higher prostate-specific antigen, and higher white blood cell and neutrophil counts. A multivariable model adjusted for age, prostate-specific antigen, and C-reactive protein showed that the white blood cell count and the neutrophil count were independently associated with prostate volume. An increased white blood cell count was also associated with higher total International Prostatic Symptom Scores (P < 0.001).
  
  
  CONCLUSIONS
  White blood cell count seems to be associated with the degree of prostate enlargement and lower urinary tract symptoms. Chronic low-grade systemic inflammation might be involved in the etiology of benign prostatic hyperplasia.
authors: Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Urology, Osaka General Medical Center, Osaka, Japan.
authors: Kazutoshi
authors: K
authors: Fujita
authors: Masahiro
authors: M
authors: Hosomi
authors: Masahiro
authors: M
authors: Nakagawa
authors: Go
authors: G
authors: Tanigawa
authors: Ryoichi
authors: R
authors: Imamura
authors: Motohide
authors: M
authors: Uemura
authors: Yasutomo
authors: Y
authors: Nakai
authors: Hitoshi
authors: H
authors: Takayama
authors: Seiji
authors: S
authors: Yamaguchi
authors: Norio
authors: N
authors: Nonomura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000097:blood*
chemical_list: D015415:Biomarkers
keywords: benign prostatic hyperplasia; prostate; white blood cell count