title: Pyothorax-associated lymphoma (PAL) with biclonal Epstein-Barr virus infection: characterization of a novel PAL cell line with unique features.
abstract: Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this rare lymphoma, but reports of PAL-derived cell lines are scarce. We report a new PAL cell line, designated Pal-2, with unique phenotypic expression. Pal-2 is the first PAL cell line that carries a biclonal EBV infection with abundant viral genome and that exhibits tumorigenic capacity once injected into nude mice.
authors: Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan.
authors: Ayuko
authors: A
authors: Taniguchi
authors: Yumiko
authors: Y
authors: Hashida
authors: Yuiko
authors: Y
authors: Nemoto
authors: Takahiro
authors: T
authors: Taguchi
authors: Yoshihito
authors: Y
authors: Iwahara
authors: Masanori
authors: M
authors: Daibata
mesh_terms: D000368:Aged; D000818:Animals; D015139:Blotting, Southern; D020732:Cytogenetic Analysis; D004654:Empyema, Tuberculous / Q000235:genetics / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000235:genetics / Q000821:virology*; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity; D010641:Phenotype; D014407:Tumor Cells, Cultured
keywords: Biclonal viral genome; Cell line; Epstein–Barr virus; Pyothorax-associated lymphoma