title: Transcription factor-induced enhancer modulations during cell fate conversions.
abstract: The activity of transcription factors (TFs) has empowered the reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) and alternative lineages. Elucidation of the molecular mechanisms underpinning these processes has expanded our understanding of how novel gene expression programs become activated while old ones are silenced. How TFs modify chromatin and activate requisite enzymes during these processes has recently been discussed in several excellent reviews. Here we discuss the questions of how ectopically expressed TFs access chromatin to modulate enhancers and establish a novel transcriptome during cell reprogramming, lineage conversions and differentiation.
authors: Gene Regulation, Stem Cells and Cancer Program, Center for Genomic Regulation and Pompeu Fabra University, Barcelona, Spain. Electronic address: chris.vanoevelen@crg.eu.
authors: C
authors: C
authors: van Oevelen
authors: E M
authors: EM
authors: Kallin
authors: T
authors: T
authors: Graf
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D065150:Cellular Reprogramming / Q000235:genetics*; D002843:Chromatin / Q000235:genetics; D053595:Embryonic Stem Cells / Q000166:cytology; D004742:Enhancer Elements, Genetic; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics; D059467:Transcriptome / Q000235:genetics
chemical_list: D002843:Chromatin; D014157:Transcription Factors