title: Drug-coated balloons for treatment of coronary artery disease: updated recommendations from a consensus group.
abstract: OBJECTIVE
  Drug-coated balloon catheters (DCB) are a new clinical treatment modality for coronary and peripheral artery disease. The goal of the consensus group is to develop recommendations for the clinical use of DCB based on randomized clinical trials and the best available clinical evidence. The present paper gives an update on the recommendations against the background of a variety of new data published since the first paper was presented.
  
  
  RESULTS
  The general concept of our recommendations for the coronary use of DCB includes the preparation of the lesion to facilitate drug delivery and to estimate the need for stent implantation, especially after relevant dissections. Lesion preparation includes conventional angioplasty. In more complex lesions, additional treatments and imaging or functional measurements are helpful. In case of no flow-limiting dissection and an acceptable but not stent-like primary result, DCB use without additional stent implantation may be considered. The proposed advantages of the DCB only concept over a direct stent approach include reduced restenosis rates in indications where DES show limited efficacy, the reduction of DAPT especially in patients with contraindications for prolonged DAPT, and the option of leaving no foreign object behind resulting in vascular restoration with potentially plaque regression instead of neo-atherosclerosis.
  
  
  CONCLUSIONS
  DCB allow for local drug delivery in endovascular therapy leaving no permanent implant behind.
authors: Charité, University Medicine, Berlin, Germany.
authors: Franz X
authors: FX
authors: Kleber
authors: Harald
authors: H
authors: Rittger
authors: Klaus
authors: K
authors: Bonaventura
authors: Uwe
authors: U
authors: Zeymer
authors: Jochen
authors: J
authors: Wöhrle
authors: Raban
authors: R
authors: Jeger
authors: Benny
authors: B
authors: Levenson
authors: Sven
authors: S
authors: Möbius-Winkler
authors: Leonhard
authors: L
authors: Bruch
authors: Dieter
authors: D
authors: Fischer
authors: Christian
authors: C
authors: Hengstenberg
authors: Tudor
authors: T
authors: Pörner
authors: Detlef
authors: D
authors: Mathey
authors: Bruno
authors: B
authors: Scheller
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods*; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology; D016503:Drug Delivery Systems; D054855:Drug-Eluting Stents; D006801:Humans; D058729:Peripheral Arterial Disease / Q000628:therapy*; D058226:Plaque, Atherosclerotic / Q000628:therapy
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