title: A rare malignancy of the parotid gland in a 13-year-old Taiwanese boy: case report of a mammary analogue secretory carcinoma of the salivary gland with molecular study.
abstract: Mammary analogue secretory carcinoma (MASC) is a recently described malignancy of the salivary glands characterized by an ETV6-NTRK3 (EN) fusion gene. Morphologically, MASC is sometimes difficult to distinguish from acinic cell carcinoma. Consequently, identifying the chromosomal translocation is essential for diagnosis. We present a case of parotid gland MASC in a 13-year-old boy. To the best of our knowledge, this is the youngest case reported in the literature. Histologic evaluation showed a tumor composed of microcysts, tubular structures, solid nests, or papillary architecture, with secretions within the lumens of the cysts or tubules. Immunohistochemically, tumor cells showed diffuse positive staining of S-100 protein, cytokeratin 19, and vimentin. ETV6 rearrangement was detected by fluorescence in situ hybridization and EN fusion transcripts were verified by reverse transcription (RT-PCR) assay.
authors: Department of Surgical Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua, Taiwan, ROC.
authors: Michael J
authors: MJ
authors: Hwang
authors: Pei Ru
authors: PR
authors: Wu
authors: Chih-Ming
authors: CM
authors: Chen
authors: Chia-Yu
authors: CY
authors: Chen
authors: Chih-Jung
authors: CJ
authors: Chen
mesh_terms: D000293:Adolescent; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D003937:Diagnosis, Differential; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D053539:Keratin-19 / Q000378:metabolism; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010306:Parotid Gland / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D009418:S100 Proteins / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D013624:Taiwan; D014746:Vimentin / Q000378:metabolism; D000097764:ETS Translocation Variant 6 Protein; D020812:Receptor, trkC
chemical_list: D053539:Keratin-19; D015514:Oncogene Proteins, Fusion; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D009418:S100 Proteins; D014746:Vimentin; D000097764:ETS Translocation Variant 6 Protein; C484319:ETV6-NTRK3 fusion protein, human; D020812:Receptor, trkC
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