title: Resilin-Based Hybrid Hydrogels for Cardiovascular Tissue Engineering.
abstract: The outstanding elastomeric properties of natural resilin, an insect protein, have motivated the engineering of resilin-like polypeptides (RLPs) as a potential material for cardiovascular tissue engineering. The RLPs, which incorporate biofunctional domains for cell-matrix interactions, are cross-linked into RLP-PEG hybrid hydrogels via a Michael-type addition of cysteine residues on the RLP with vinyl sulfones of an end-functionalized multi-arm star PEG. Oscillatory rheology indicated the useful mechanical properties of these materials. Assessments of cell viability via con-focal microscopy clearly show the successful encapsulation of human aortic adventitial fibroblasts in the three-dimensional matrices and the adoption of a spread morphology following 7 days of culture.
authors: Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
authors: Christopher L
authors: CL
authors: McGann
authors: Eric A
authors: EA
authors: Levenson
authors: Kristi L
authors: KL
authors: Kiick
keywords: biomaterials; elastomers; hydrogels; mechanical properties; tissue engineering
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