title: Comparative analysis of clinical, electrocardiographic, angiographic and echocardiographic data of indigenous and non-indigenous residents of Yakutia with coronary artery atherosclerosis.
abstract: OBJECTIVE
  The aim of the study is to compare clinical, angiographic, electrocardiographic, echocardiographic data between indigenous and non-indigenous residents of Yakutia.
  
  
  METHODS
  We performed cross-sectional analysis of the Registry of Selective Coronary Angiography (SCAG) of the Yakutsk Republican Hospital for the period from 2004 to 2007. All patients (n = 1,233) were admitted to hospital from all 35 regions of the Sakha Republic (Yakutia). Initially, 12 (1%) patients, who had abnormal coronary arteries and 259 (21%) patients with normal coronary arteries were excluded from this study. From the remaining 962 (78%) patients with detected coronary artery atherosclerosis 394 (41%) patients were excluded for having congenital heart malformations due to possible influence on the outcomes of examination for myocardial hypertrophy. Finally, only 568 patients were selected for further examinations.
  
  
  METHODS
  We analyzed clinical data, and the findings of selective angiography, multi-detector computed tomography (CT), electrocardiography (ECG), 24-hour Holter ECG monitoring and echocardiography.
  
  
  RESULTS
  (a) In the Sakha Republic (Yakutia) single-vessel coronary disease, coronary stenosis with 50-75% and 75-90% of constriction were detected more often among indigenous males, while multiple-vessel coronary stenosis was detected more often among non-indigenous males as well as stenosis with more than 90% of constriction. Lower calcium score mean (349.1 ± 129.8 vs. 621.8 ± 115.2) was observed among indigenous patients compared to non-indigenous patients; (b) Painless myocardial infarction, painless ischaemia, arterial hypertension and atrial fibrillation were detected more often among indigenous male compared to non-indigenous participants; (c) Based on the results of ECG and echocardiographic examinations, left ventricular (LV) hypertrophy, particular eccentric type of hypertrophy, was found more commonly among indigenous than non-indigenous males; and (d) By laboratory findings, indigenous males had significantly lower triglyceride levels, while platelet counts were higher compared to non-indigenous patients. Obesity was observed less frequently among indigenous men compared to non-indigenous men.
  
  
  CONCLUSIONS
  The differences observed in this study are disputable and call for further studies. Collection of reliable data for women should be the aim of future studies.
authors: Yakutsk Scientific Center, SB RAMS, Yakutsk, Russia. makharova@mail.ru
authors: Natalya Vladimirovna
authors: NV
authors: Makharova
authors: Michael Ivanovich
authors: MI
authors: Voevoda
authors: Faina Fedorovna
authors: FF
authors: Lyutova
authors: Irina Andreevna
authors: IA
authors: Pinigina
authors: Vera Evstafievna
authors: VE
authors: Tarasova
mesh_terms: D000367:Age Factors; D001110:Arctic Regions / Q000453:epidemiology; D044466:Asian People; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000208:ethnology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000208:ethnology*; D003430:Cross-Sectional Studies; D015716:Electrocardiography, Ambulatory; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D015994:Incidence; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000208:ethnology; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012907:Smoking / Q000208:ethnology; D014057:Tomography, X-Ray Computed
chemical_list: D008055:Lipids
keywords: Yakutia; atherosclerosis; eccentric hypertrophy; indigenous population; non-indigenous population
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