title: Redox-neutral α-C-H bond functionalization of secondary amines with concurrent C-P bond formation/N-alkylation.
abstract: Redox-neutral formation of C-P bonds in the α-position of amines was achieved via a process that features a combination of an oxidative α-C-H bond functionalization and a reductive N-alkylation. Benzoic acid functions as an efficient catalyst in this three-component reaction of cyclic secondary amines, aldehydes and phosphine oxides to provide rapid access to α-amino phosphine oxides not easily accessible by classic Kabachnik-Fields reactions.
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors: Deepankar
authors: D
authors: Das
authors: Daniel
authors: D
authors: Seidel
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D019817:Benzoic Acid / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010720:Phosphines / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D010720:Phosphines; D019817:Benzoic Acid; C044646:phosphine
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