title: [Acetaminophen - A modern classic under suspicion].
abstract: Paracetamol is one of the most popular and widely used drugs for the treatment of pain and fever and provides safe and effective relief of these symptoms since decades. The mechanism of action is very complex and involves the inhibition of the peroxidase portion of the cyclooxygenase enzyme together with the modulation of the serotoninergic and cannabinoid system. Paracetamol is a safe drug, if used in accordance with the regulations and has demonstrated a superior side effect profile to many widely used NSAIDs.
authors: Chemiker, Aachen. hbuschmann@gmail.com
authors: H
authors: H
authors: Buschmann
authors: K
authors: K
authors: Heintze
authors: E
authors: E
authors: Morgenstern
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D011247:Pregnancy; D018570:Risk Assessment; D013116:Spinal Cord / Q000187:drug effects
chemical_list: D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D000082:Acetaminophen