title: Effects of resveratrol on daily rhythms of locomotor activity and body temperature in young and aged grey mouse lemurs.
abstract: In several species, resveratrol, a polyphenolic compound, activates sirtuin proteins implicated in the regulation of energy balance and biological clock processes. To demonstrate the effect of resveratrol on clock function in an aged primate, young and aged mouse lemurs (Microcebus murinus) were studied over a 4-week dietary supplementation with resveratrol. Spontaneous locomotor activity and daily variations in body temperature were continuously recorded. Reduction in locomotor activity onset and changes in body temperature rhythm in resveratrol-supplemented aged animals suggest an improved synchronisation on the light-dark cycle. Resveratrol could be a good candidate to restore the circadian rhythms in the elderly.
authors: Mécanismes Adaptatifs et Evolution, UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France. pifferi@mnhn.fr
authors: Fabien
authors: F
authors: Pifferi
authors: Alexandre
authors: A
authors: Dal-Pan
authors: Solène
authors: S
authors: Languille
authors: Fabienne
authors: F
authors: Aujard
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D016565:Cheirogaleidae; D002940:Circadian Rhythm / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
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