title: Assessment of drinking water fortification with iron plus ascorbic Acid or ascorbic Acid alone in daycare centers as a strategy to control iron-deficiency anemia and iron deficiency: a randomized blind clinical study.
abstract: OBJECTIVE
  Assess drinking water fortification with iron and/or ascorbic acid as a strategy to control iron-deficiency anemia and iron deficiency.
  
  
  METHODS
  Randomized blind clinical study, fortifying drinking water to 153 pre-school children during 3 months, with iron and ascorbic acid (A), ascorbic acid (B) or plain water (C). Hemoglobin (Hb), mean corpuscular volume (MCV) and ferritin were measured.
  
  
  RESULTS
  Within the groups, Hb raised in all three groups, MCV in A and B and ferritin in A. The difference between time points 0 and 1 was significant between A and B for Hb, when A and B were compared with C for MCV and when A was compared with either B or C for ferritin.
  
  
  CONCLUSIONS
  Water fortification is efficient in controlling iron deficiency and anemia. Iron stores' recovery depends on a more effective offer of iron. Water fortification must be preceded by a careful assessment of the previous nutritional status.
authors: University of Ribeirão Preto, Eugênio Ferrante, 170, Ribeirão Preto - SP - Brazil, CEP 14027-150.
authors: Carlos A N
authors: CA
authors: de Almeida
authors: Elza D
authors: ED
authors: De Mello
authors: Adriana P R
authors: AP
authors: Ramos
authors: Camila A
authors: CA
authors: João
authors: Carolina R
authors: CR
authors: João
authors: José E
authors: JE
authors: Dutra-de-Oliveira
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001938:Brazil / Q000453:epidemiology; D002656:Child Day Care Centers; D002675:Child, Preschool; D004311:Double-Blind Method; D060766:Drinking Water; D005260:Female; D005527:Food, Fortified; D006454:Hemoglobins / Q000032:analysis* / Q000187:drug effects; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D000090463:Iron Deficiencies; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D015995:Prevalence; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D060766:Drinking Water; D006454:Hemoglobins; D014815:Vitamins; D007501:Iron; D001205:Ascorbic Acid
keywords: anemia; health education; iron deficiency; nutrition assessment