title: A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses.
abstract: Equine recurrent uveitis (ERU) is a common eye disease affecting up to 3-15% of the horse population. A genome-wide association study (GWAS) using the Illumina equine SNP50 bead chip was performed to identify loci conferring risk to ERU. The sample included a total of 144 German warmblood horses. A GWAS showed a significant single nucleotide polymorphism (SNP) on horse chromosome (ECA) 20 at 49.3 Mb, with IL-17A and IL-17F being the closest genes. This locus explained a fraction of 23% of the phenotypic variance for ERU. A GWAS taking into account the severity of ERU, revealed a SNP on ECA18 nearby to the crystalline gene cluster CRYGA-CRYGF. For both genomic regions on ECA18 and 20, significantly associated haplotypes containing the genome-wide significant SNPs could be demonstrated. In conclusion, our results are indicative for a genetic component regulating the possible critical role of IL-17A and IL-17F in the pathogenesis of ERU. The associated SNP on ECA18 may be indicative for cataract formation in the course of ERU.
authors: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany ; Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany.
authors: Maike
authors: M
authors: Kulbrock
authors: Stefanie
authors: S
authors: Lehner
authors: Julia
authors: J
authors: Metzger
authors: Bernhard
authors: B
authors: Ohnesorge
authors: Ottmar
authors: O
authors: Distl
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses / Q000235:genetics*; D016014:Linear Models; D012008:Recurrence; D012307:Risk Factors; D014605:Uveitis / Q000235:genetics / Q000662:veterinary*
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