title: Cartilage to bone transitions in health and disease.
abstract: Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inherently 'stable' cartilage. Lessons may be learnt from the molecular mechanisms underpinning transient chondrocyte differentiation and function, and their application may better identify disease aetiology. Here, we review the current evidence supporting this possibility. We firstly outline endochondral ossification and the cellular and physiological mechanisms by which it is controlled in the postnatal growth plate. We then compare the biology of these transient cartilaginous structures to the inherently stable articular cartilage. Finally, we highlight specific scenarios in which the redeployment of these embryonic processes may contribute to disease development, with the foresight that deciphering those mechanisms regulating pathological changes and loss of cartilage stability will aid future research into effective disease-modifying therapies.
authors: Comparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
authors: K A
authors: KA
authors: Staines
authors: A S
authors: AS
authors: Pollard
authors: I M
authors: IM
authors: McGonnell
authors: C
authors: C
authors: Farquharson
authors: A A
authors: AA
authors: Pitsillides
mesh_terms: D001846:Bone Development / Q000502:physiology*; D001847:Bone Diseases / Q000503:physiopathology*; D002356:Cartilage / Q000254:growth & development / Q000502:physiology; D002358:Cartilage, Articular / Q000166:cytology / Q000473:pathology; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology; D004838:Epiphyses; D006132:Growth Plate / Q000166:cytology; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000503:physiopathology; D009999:Ossification, Heterotopic / Q000503:physiopathology; D010003:Osteoarthritis / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D010641:Phenotype
keywords: bone; cartilage; chondrocyte; endochondral ossification; osteoarthritis
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