title: Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin.
abstract: We report a case of chronic leg ulceration occurring in a patient with necrobiosis lipoidica (NL). After many topical treatments had failed to achieve healing, treatment with topical becaplermin was started, which resulted in rapid improvement and ultimately complete healing of the ulceration. Treatment of ulcerated NL is often disappointing. Many topical and systemic drugs have been tried. Becaplermin is a platelet-derived growth factor indicated for the treatment of neuropathic diabetic ulcers measuring < 50 mm in size. To our knowledge, this is only the second case reported in the literature of ulcerated NL successfully treated with becaplermin.
authors: Department of Dermatology, CHU de Tours, France.
authors: V
authors: V
authors: Tauveron
authors: A
authors: A
authors: Rosen
authors: M
authors: M
authors: Khashoggi
authors: M
authors: M
authors: Abdallah-Lotf
authors: L
authors: L
authors: Machet
mesh_terms: D000287:Administration, Topical; D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage*; D000077214:Becaplermin; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000473:pathology; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D020574:Proto-Oncogene Proteins c-sis / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D043925:Angiogenesis Inducing Agents; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin