title: Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer.
abstract: OBJECTIVE
  To assess the clinical efficacy of targeted arterial perfusion of verapamil and chemotherapeutic agents in the interventional therapy of lung cancer.
  
  
  METHODS
  Forty patients with advanced lung cancer underwent treatment with targeted arterial perfusion of verapamil and chemotherapeutic agents using Seldinger technique. Interventional therapy was performed once a month, and each subject received interventional treatment for 2 or more cycles. The therapeutic efficacy was evaluated 2 months post-treatment.
  
  
  RESULTS
  Out of 40 patients with advanced lung cancer, 5 cases achieved complete remission (CR) and 29 cases achieved partial remission (PR), with a total effectiveness (CR + PR) rate of 85 %. Besides, 32 cases achieved significantly alleviated clinical symptoms, and 29 cases had decreased clinical tumor stage. All subjects had stable karnofsky performance status score and body weight. Among the 40 patients, 13 cases had leucopenia, 10 cases had gastrointestinal reactions, 3 cases presented with elevated alanine aminotransferase/aspartate aminotransferase ratio, and 3 cases had fever. However, all these side effects relieved quickly. No elevation of BUN/Cr ratio and allergic reactions was observed. No significant changes in cardiac function and electrocardiogram were noticed after the treatment.
  
  
  CONCLUSIONS
  Targeted arterial perfusion of verapamil and chemotherapeutic drugs can improve the clinical symptoms of patients with advanced lung cancer and increase the efficacy of chemotherapeutic agents, thereby providing an opportunity for radiotherapy or surgical treatment for advanced lung cancer.
authors: Department of Medical Oncology, Anhui Provincial Cancer Hospital, Anhui Medical University, 107 Huanhu Road East, Hefei, 230031, People's Republic of China.
authors: Jin
authors: J
authors: Huang
authors: Tengyue
authors: T
authors: Zhang
authors: Kelong
authors: K
authors: Ma
authors: Pingsheng
authors: P
authors: Fan
authors: Yabei
authors: Y
authors: Liu
authors: Chengtao
authors: C
authors: Weng
authors: Gaofei
authors: G
authors: Fan
authors: Qiaohong
authors: Q
authors: Duan
authors: Xianhai
authors: X
authors: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D010477:Perfusion / Q000379:methods; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D014700:Verapamil
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