title: Association between increased epicardial adipose tissue volume and coronary plaque composition.
abstract: To assess the relationship between epicardial adipose tissue volume (EATV) and plaque vulnerability in significant coronary stenosis using a 40-MHz intravascular ultrasound (IVUS) imaging system (iMap-IVUS), we analyzed 130 consecutive patients with coronary stenosis who underwent dual-source computed tomography (CT) and cardiac catheterization. Culprit lesions were imaged by iMap-IVUS before stenting. The iMAP-IVUS system classified coronary plaque components as fibrous, lipid, necrotic, or calcified tissue, based on the radiofrequency spectrum. Epicardial adipose tissue was measured as the tissue ranging from -190 to -30 Hounsfield units. EATV, calculated as the sum of the fat areas on short-axis images, was 85.0 ± 34.0 cm(3). There was a positive correlation between EATV and the percentage of necrotic plaque tissue (R (2) = 0.34, P < 0.01), while there was a negative correlation between EATV and the percentage of fibrous tissue (R (2) = 0.24, P < 0.01). Multivariate analysis revealed that an increased low-density lipoprotein cholesterol level (β = 0.15, P = 0.03) and EATV (β = 0.14, P = 0.02) were independently associated with the percentage of necrotic plaque tissue. An increase in EATV was associated with the development of coronary atherosclerosis and, potentially, with the most dangerous type of plaque.
authors: Division of Cardiology and Cardiac Catheterization Laboratories, Showa University Northern Yokohama Hospital, 35-1, Chigasaki-chuo, Tsuzuki, Yokohama, Kanagawa, 224-8503, Japan, kennosuke.atmm3@gmail.com.
authors: Kennosuke
authors: K
authors: Yamashita
authors: Myong Hwa
authors: MH
authors: Yamamoto
authors: Seitarou
authors: S
authors: Ebara
authors: Toshitaka
authors: T
authors: Okabe
authors: Shigeo
authors: S
authors: Saito
authors: Koichi
authors: K
authors: Hoshimoto
authors: Tadayuki
authors: T
authors: Yakushiji
authors: Naoei
authors: N
authors: Isomura
authors: Hiroshi
authors: H
authors: Araki
authors: Chiaki
authors: C
authors: Obara
authors: Masahiko
authors: M
authors: Ochiai
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009336:Necrosis; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation; D010496:Pericardium / Q000000981:diagnostic imaging*; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015607:Stents; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional; D061205:Vascular Calcification / Q000000981:diagnostic imaging
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL
references: Circulation. 1995 Aug 1;92(3):657-71
references: 7634481
references: Circulation. 2004 Jul 13;110(2):227-39
references: 15249516
references: Circulation. 2004 Nov 30;110(22):3424-9
references: 15557374
references: N Engl J Med. 2005 Apr 7;352(14):1425-35
references: 15755765
references: Heart Vessels. 2014 Jan;29(1):42-8
references: 23296264
references: Circulation. 1975 Apr;51(4 Suppl):5-40
references: 1116248
references: Atherosclerosis. 2010 May;210(1):150-4
references: 20031133
references: Invest Radiol. 2005 Feb;40(2):97-101
references: 15654254
references: JACC Cardiovasc Imaging. 2010 Nov;3(11):1104-12
references: 21070997
references: Circulation. 2003 Nov 18;108(20):2460-6
references: 14581396
references: Circulation. 2002 Dec 17;106(25):3143-421
references: 12485966
references: JACC Cardiovasc Imaging. 2010 Apr;3(4):352-60
references: 20394896
references: EuroIntervention. 2009 May;5(1):133-9
references: 19577995
references: Dev Biol. 1978 Oct;66(2):579-85
references: 700255
references: J Am Coll Cardiol. 2001 Apr;37(5):1478-92
references: 11300468
references: J Am Coll Cardiol. 1990 Mar 15;15(4):827-32
references: 2407762
references: Circulation. 2008 Feb 5;117(5):605-13
references: 18212276
references: Heart Vessels. 2012 Sep;27(5):443-52
references: 21837498
references: Cardiovasc Diabetol. 2006 Jan 13;5:1
references: 16412224
references: J Am Coll Cardiol. 2009 Dec 8;54(24):2290-5
references: 19958964
references: Eur Heart J. 2009 Apr;30(7):850-6
references: 19136488