title: Hepatitis B virus-induced hepatocellular carcinoma.
abstract: Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.
authors: Institute for Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors: Cheng
authors: C
authors: Xu
authors: The Department of General Surgery II, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors: Wence
authors: W
authors: Zhou
authors: Institute for Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: wym417@163.com.
authors: Yuming
authors: Y
authors: Wang
authors: Storr Liver Unit, University of Sydney, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia. Electronic address: liang.qiao@sydney.edu.au.
authors: Liang
authors: L
authors: Qiao
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D002472:Cell Transformation, Viral; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D005838:Genotype; D006509:Hepatitis B / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D018836:Inflammation Mediators; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein
keywords: Carcinogenesis; HBV; HBVx; HCC