title: Fine needle aspiration biopsy of ophthalmic tumors.
abstract: A majority of intraocular tumors can be diagnosed based on clinical examination and ocular imaging studies, which obviate the need for diagnostic ophthalmic fine needle aspiration biopsy (FNAB). Overall, diagnostic accuracy of ophthalmic FNAB is high but limited cellularity can compromise the diagnostic potential of ophthalmic aspirate samples. The role of ophthalmic FNAB is limited in retinal tumors. Orbital FNAB should be considered in the evaluation of lacrimal gland tumors, orbital metastasis, and lymphoproliferative lesions. Negative cytologic diagnosis of malignancy should not be considered unequivocal proof that an intraocular malignancy does not exist. With improved understanding of genetic prognostic factors of uveal melanoma, ophthalmic FNAB is gaining popularity for prognostic purposes in combination with eye conserving treatment of the primary tumor. In special clinical indications, ancillary studies such as immunohistochemistry and FISH can be performed on ophthalmic FNAB samples. Assistance of an experienced cytopathologist cannot be overemphasized.
authors: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors: Arun D
authors: AD
authors: Singh
authors: Charles V
authors: CV
authors: Biscotti
keywords: Cytology; FNAB; Melanoma; Metastases; Uvea
references: Surv Ophthalmol. 1985 May-Jun;29(6):410-22
references: 3892741
references: Monogr Clin Cytol. 2012;21:55-60
references: 22024584
references: Am J Ophthalmol. 2005 Dec;140(6):1002-6
references: 16376642
references: Diagn Cytopathol. 2008 Nov;36(11):773-5
references: 18831026
references: Diagn Cytopathol. 1996 Mar;14(2):182-3
references: 8964178
references: Ophthalmology. 2009 Jan;116(1):163-163.e6
references: 19118703
references: Monogr Clin Cytol. 2012;21:72-81
references: 22024586
references: Maturitas. 2009 Feb 20;62(2):113-23
references: 19167175
references: Int Ophthalmol Clin. 1993 Summer;33(3):77-82
references: 8407195
references: Ann Clin Lab Sci. 2008 Summer;38(3):296-9
references: 18715862
references: Trans Am Ophthalmol Soc. 1952;50:375-405
references: 13102568
references: Arch Ophthalmol. 2007 Aug;125(8):1017-24
references: 17698747
references: Ophthalmology. 1984 Jun;91(6):726-49
references: 6379545
references: Int Ophthalmol Clin. 1999 Winter;39(1):213-22
references: 10083918
references: World J Surg. 2010 Apr;34(4):844-51
references: 20049437
references: Monogr Clin Cytol. 2012;21:1-9
references: 22024579
references: Ophthalmology. 2002 Feb;109(2):235-42
references: 11825801
references: Ophthalmology. 1979 Sep;86(9):1662-81
references: 551354
references: Acta Ophthalmol (Copenh). 1959;37:568-75
references: 14407130
references: Br J Ophthalmol. 2006 Apr;90(4):420-2
references: 16547317
references: Am J Ophthalmol. 1951 Mar;34(3):432-4
references: 14819160
references: Br J Ophthalmol. 2011 Jan;95(1):79-82
references: 21163820
references: Acta Cytol. 1989 Sep-Oct;33(5):599-605
references: 2781961
references: Monogr Clin Cytol. 2012;21:10-6
references: 22024580
references: AMA Arch Ophthalmol. 1953 Sep;50(3):303-10
references: 13079368
references: Retina. 2002 Dec;22(6):707-10
references: 12476095
references: Hum Pathol. 1983 Jan;14(1):9-28
references: 6187655
references: Am J Ophthalmol. 1990 Oct 15;110(4):361-5
references: 2220969
references: Acta Cytol. 2004 Jul-Aug;48(4):487-91
references: 15296338
references: Monogr Clin Cytol. 2012;21:44-54
references: 22024583
references: Eur J Ophthalmol. 2010 Nov-Dec;20(6):1059-65
references: 20602321
references: Trans Am Ophthalmol Soc. 1988;86:499-560
references: 2979028
references: Acta Ophthalmol. 2009 Sep;87(6):588-601
references: 19719804
references: Ophthalmology. 2006 Nov;113(11):2080-6
references: 17074566
references: Monogr Clin Cytol. 2012;21:82-9
references: 22024587
references: Am J Ophthalmol. 1984 Jun;97(6):686-90
references: 6731534
references: Ophthalmology. 1992 Feb;99(2):250-6
references: 1553217
references: Klin Monbl Augenheilkd. 1978 Sep;173(3):416-8
references: 374843
references: Acta Cytol. 2005 May-Jun;49(3):297-308
references: 15966293
references: Cancer. 1984 Jul 1;54(1):73-8
references: 6722746
references: Ophthalmology. 1997 Aug;104(8):1265-76
references: 9261313
references: Ophthalmology. 1985 Dec;92(12):1763-7
references: 4088631
references: Am J Ophthalmol. 1967 Sep;64(3):Suppl:591-9
references: 6039081
references: Arch Ophthalmol. 1992 Jul;110(7):969-76
references: 1637283
references: Acta Ophthalmol Scand. 1999 Aug;77(4):448-52
references: 10463420
references: Nippon Ganka Gakkai Zasshi. 1967 Aug;71(8):1317-22
references: 5625598
references: Br J Ophthalmol. 1995 Jul;79(7):692-6
references: 7662638
references: Cytopathology. 2001 Feb;12(1):1-6
references: 11256932
references: Eye (Lond). 2001 Apr;15(Pt 2):143-7
references: 11339578
references: Am J Ophthalmol. 1988 May 15;105(5):538-46
references: 3369520
references: Ophthalmology. 1985 Jan;92(1):39-49
references: 3974994
references: Ophthalmic Surg. 1984 Jan;15(1):34-40
references: 6700944
references: Graefes Arch Clin Exp Ophthalmol. 2006 Apr;244(4):524-8
references: 16170536
references: Acta Cytol. 1983 Mar-Apr;27(2):157-65
references: 6573087
references: J Clin Pathol. 1997 Jul;50(7):541-3
references: 9306930
references: Acta Ophthalmol (Copenh). 1954;32(5):645-57
references: 14387647
references: Am J Ophthalmol. 2008 Feb;145(2):297-302
references: 18062935
references: Monogr Clin Cytol. 2012;21:17-30
references: 22024581
references: Ophthalmol Clin North Am. 2005 Mar;18(1):177-85, x
references: 15763203
references: Ophthalmology. 1993 Nov;100(11):1677-84
references: 8233394
references: Br J Ophthalmol. 1988 Dec;72(12):905-11
references: 3067746
references: Acta Cytol. 1975 Jan-Feb;19(1):32-7
references: 46659
references: Ophthalmology. 2006 Jun;113(6):1028-31
references: 16751041
references: Acta Ophthalmol. 2009 Sep;87(6):586-7
references: 19719803
references: Acta Cytol. 1998 Mar-Apr;42(2):362-6
references: 9568136
references: Eye (Lond). 1992;6 ( Pt 1):11-27
references: 1426393
references: Am J Ophthalmol. 1997 Sep;124(3):362-72
references: 9439362