title: Changes in expression of calbindin 28 kDa in the small intestine of red kidney bean (Phaseolus vulgaris) lectin-treated suckling piglets.
abstract: Calbindin (CB) is a calcium binding protein playing a role in calcium uptake and anti-apoptotic cellular protection. The expression of CB was immunohistochemically studied in the small intestine of normal and red bean kidney lectin-treated suckling piglets. In the duodenum and jejunum (but not ileum) of lectin-treated animals overexpression of CB was noted in chromogranin A-immunoreactive (CgA-IR) neuroendocrine (NE) cells. In both control and experimental group a small population of CB-IR NE cells exhibited the presence of somatostatin (but not serotonin, histamine or CRF). After the lectin treatment, an increased (however not statistically significant) immunoreactivity to CB was found in a small subpopulation of neurons of outer submucous (but not inner submucous and myenteric) plexus. It is suggested that there is a functional interaction between lectin administration and CB-expression in the porcine small intestine. Future studies will be needed to clarify this processes.
authors: Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland. asiembida13@wp.pl
authors: A
authors: A
authors: Zacharko-Siembida
authors: J L Valverde
authors: JL
authors: Piedra
authors: M B
authors: MB
authors: Arciszewski
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000833:Animals, Suckling; D064026:Calbindins; D004032:Diet / Q000662:veterinary*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008297:Male; D027805:Phaseolus / Q000737:chemistry*; D037121:Plant Lectins / Q000737:chemistry / Q000494:pharmacology*; D064030:S100 Calcium Binding Protein G / Q000235:genetics / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*
chemical_list: D064026:Calbindins; D037121:Plant Lectins; D064030:S100 Calcium Binding Protein G