title: Prevalence of and risk factors for osteoporosis and fracture among a male HIV-infected population in the UK.
abstract: Rates of osteoporosis and fracture may be increased in HIV but there are few UK data. Our aim was to examine the prevalence of and risk factors for osteoporosis and fractures among a homogeneous cohort of well-characterized HIV-infected men. In total, 168 men were recruited, median age 45 years, 37 combination antiretroviral therapy (cART) naïve, 46 with <3 years cART exposure and 85 cART-exposed longer term (median >10 years). All participants provided information on bone health and underwent DEXA scanning. Osteopenia was found in 58% of subjects and osteoporosis in 12%; 14% reported fractures since HIV diagnosis. Number of fractures since HIV diagnosis was significantly increased among those with osteoporosis (OR 3.5, 95% CI 1.2-10.4, p = 0.018). Duration of infection greater than 13 years was significantly associated with osteoporosis. Duration of cART was associated in univariate but not multivariate analyses. Strategies to prevent osteoporosis and fractures in HIV will require attention to viral and lifestyle factors and not just cART.
authors: Department of HIV Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
authors: Charlotte-Eve S
authors: CE
authors: Short
authors: Simon G
authors: SG
authors: Shaw
authors: Martin J
authors: MJ
authors: Fisher
authors: Karen
authors: K
authors: Walker-Bone
authors: Yvonne C
authors: YC
authors: Gilleece
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D003430:Cross-Sectional Studies; D050723:Fractures, Bone / Q000453:epidemiology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006784:Hospitals, Teaching; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
keywords: DEXA; HIV; Osteoporosis; ageing; antiretroviral therapy; bone density; fractures; male; osteopenia
references: Osteoporos Int. 2007 Oct;18(10):1345-53
references: 17665239
references: J Clin Endocrinol Metab. 2006 Aug;91(8):2938-45
references: 16735489
references: J Clin Endocrinol Metab. 2008 Sep;93(9):3499-504
references: 18593764
references: AIDS. 2003 Sep 5;17(13):1917-23
references: 12960824
references: AIDS. 2006 Nov 14;20(17):2165-74
references: 17086056
references: Int J STD AIDS. 2012 Aug;23(8):546-52
references: 22930290
references: Osteoporos Int. 1999;9 Suppl 2:S2-8
references: 10525719
references: Clin Infect Dis. 2011 Apr 15;52(8):1061-8
references: 21398272
references: AIDS. 2001 Sep 7;15(13):1731-3
references: 11546951
references: J Clin Endocrinol Metab. 2007 Feb;92(2):405-13
references: 17090633
references: Bone. 2001 Dec;29(6):517-22
references: 11728921
references: Osteoporos Int. 2004 Jun;15(6):439-46
references: 15205714
references: Bone. 2009 Sep;45(3):449-54
references: 19450718
references: Calcif Tissue Int. 2001 Oct;69(4):193-5
references: 11730248
references: PLoS One. 2011;6(12):e28512
references: 22174826
references: Osteoporos Int. 2011 Apr;22(4):1069-77
references: 20533026
references: Antivir Ther. 2007;12(2):261-5
references: 17503668
references: Clin Infect Dis. 2005 Dec 15;41(12):1804-5
references: 16288407
references: AIDS. 2007 Mar 12;21(5):617-23
references: 17314524
references: Clin Infect Dis. 2005 Dec 15;41(12):1794-803
references: 16288406
references: J Clin Endocrinol Metab. 2007 Dec;92(12):4522-8
references: 17925333
references: PLoS One. 2011 Feb 16;6(2):e17217
references: 21359191
references: AIDS. 2009 May 15;23(8):1021-4
references: 19300202
references: Curr Opin Infect Dis. 2010 Feb;23(1):1-8
references: 20010102
references: Curr Opin Rheumatol. 2012 Sep;24(5):567-75
references: 22820515
references: Best Pract Res Clin Rheumatol. 2009 Dec;23(6):755-68
references: 19945687
references: AIDS. 2012 Jun 1;26(9):1073-82
references: 22301413
references: BMJ. 1993 Jun 5;306(6891):1506-9
references: 8518677
references: Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):671-85
references: 19028351