title: Triterpenoids as reversal agents for anticancer drug resistance treatment.
abstract: Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR), which is one of the major obstacles in the treatment of cancer patients. None of the strategies to overcome MDR has been successfully applied in the clinic until now. Plenty of evidence shows that some triterpenoids function as reversal agents of MDR for anticancer drug resistance treatment. Here, we review the latest findings of reversing cancer MDR with triterpenoids. Findings are summarized showing that triterpenoids are MDR modulators and potential chemosensitizers. Finally, we contemplate future prospects of modulating MDR in the clinic.
authors: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.
authors: Xiao-Jian
authors: XJ
authors: Yan
authors: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.
authors: Li-Hua
authors: LH
authors: Gong
authors: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.
authors: Fei-Yun
authors: FY
authors: Zheng
authors: Chemical Biology Center, Lishui Institute of Agricultural Sciences, Lishui, Zhejiang 323000, China.
authors: Ke-Jun
authors: KJ
authors: Cheng
authors: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
authors: Zhe-Sheng
authors: ZS
authors: Chen
authors: Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China. Electronic address: tshizhi@jnu.edu.cn.
authors: Zhi
authors: Z
authors: Shi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D014315:Triterpenes