title: Meta-analysis: glutathione S-transferase T1 null allele is associated with gastric cancer risk.
abstract: Allelic variant within genes encoding glutathione S-transferase T1 (GSTT1) has been suggested to be a possible risk factor of gastric cancer, but previous studies provide controversial results. This study aimed to assess the effects of GSTT1 polymorphism on gastric cancer by means of meta-analysis. We included published studies on the relationship between GSTT1 null allele and gastric cancer risk after searching electronic databases. A meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95% confidence intervals (95% CI). Forty-two studies with a total of 8,203 gastric cancer cases and 13,866 controls were included into this meta-analysis. When all 42 studies were pooled into this meta-analysis, there was a significant association between the GSTT1 null allele and gastric cancer risk (OR = 1.24, 95% CI 1.14-1.36, P < 0.00001). Sensitivity analysis by excluding individual studies showed that there was no effect on the pooled OR with 95% CI. After excluding studies with low quality, there was still a significant association between the GSTT1 null allele and gastric cancer risk (OR = 1.24, 95% CI 1.13-1.36, P < 0.00001). In the subgroup analysis, there was a significant association between the GSTT1 null allele and gastric cancer risk in both Europeans and Asians. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null allele is associated with increased risk of gastric cancer.
authors: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang, 110004, Liaoning Province, China, sunweiliaoning@outlook.com.
authors: Wei
authors: W
authors: Sun
authors: Li
authors: L
authors: Yao
authors: Benchun
authors: B
authors: Jiang
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D016017:Odds Ratio; D017594:Publication Bias; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase
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