title: The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
abstract: BACKGROUND
  Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213.
  
  
  METHODS
  A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing.
  
  
  RESULTS
  The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76). Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03) and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13). Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia.
  
  
  CONCLUSIONS
  Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.
authors: Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors: Ji-peng
authors: JP
authors: Wan
authors: Han
authors: H
authors: Zhao
authors: Tao
authors: T
authors: Li
authors: Chang-zhong
authors: CZ
authors: Li
authors: Xie-tong
authors: XT
authors: Wang
authors: Zi-Jiang
authors: ZJ
authors: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D015820:Cadherins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: D015820:Cadherins; C099972:H-cadherin
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