title: Delirium in the acute phase after stroke and the role of the apolipoprotein E gene.
abstract: OBJECTIVE
  To study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population.
  
  
  METHODS
  527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available.
  
  
  RESULTS
  The incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOEε4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4-2.1). Delirium did not last longer in patients with an APOEε4 allele compared to patients without an APOEε4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5).
  
  
  CONCLUSIONS
  There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke.
authors: Department of Intensive Care Medicine, St Elisabeth Hospital, Tilburg, The Netherlands. Electronic address: a.oldenbeuving@elisabeth.nl.
authors: A W
authors: AW
authors: Oldenbeuving
authors: P L M
authors: PL
authors: de Kort
authors: L J
authors: LJ
authors: Kappelle
authors: C M
authors: CM
authors: van Duijn
authors: G
authors: G
authors: Roks
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053327:Apolipoprotein E4 / Q000235:genetics*; D015331:Cohort Studies; D003693:Delirium / Q000150:complications* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies; D020521:Stroke / Q000150:complications*; D013997:Time Factors
chemical_list: D053327:Apolipoprotein E4
keywords: Delirium; apolipoprotein E; stroke