title: Peripheral retinal nonperfusion in fellow eyes in coats disease.
abstract: OBJECTIVE
  To measure peripheral nonperfusion and describe bilateral vascular abnormalities in patients with Coats disease, emphasizing subtle findings in the contralateral eyes of patients diagnosed with unilateral disease.
  
  
  METHODS
  Clinical records, including retina drawings and fluorescein angiography images obtained under anesthesia, were retrospectively reviewed from consecutive pediatric patients with Coats disease. The main outcome measure was disk diameters of peripheral nonperfusion and proportion of Coats disease patients with bilateral findings.
  
  
  RESULTS
  Twenty-two of 32 patients with Coats disease had bilateral abnormal peripheral vasculature. In Group 1 (classic Coats disease: presumed unilateral, ocular only disease), 15 of 24 patients had peripheral nonperfusion >2 disk diameters in their contralateral eyes, 5 with telangiectasis and/or microaneurysms. Seven of 8 patients in Group 2 (Coats-like disease: systemic and/or clinically bilateral disease) had bilateral vascular anomalies.
  
  
  CONCLUSIONS
  Bilateral vascular abnormalities are more common in Coats disease than previously reported. This observation supports a systemic and/or genetic association with Coats disease. Patients with Coats disease should have careful evaluation of the periphery of the less affected eye, preferably with fluorescein angiography, to identify vascular changes not visible clinically. Both eyes warrant surveillance over the lifetime of the patient for potential progression to exudative disease that would warrant treatment.
authors: Retina Consultants, Des Plaines, IL 60016, USA.
authors: Michael P
authors: MP
authors: Blair
authors: J Niklas
authors: JN
authors: Ulrich
authors: M
authors: M
authors: Elizabeth Hartnett
authors: Michael J
authors: MJ
authors: Shapiro
mesh_terms: D000293:Adolescent; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007223:Infant; D017075:Laser Coagulation; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D015356:Retinal Artery Occlusion / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D058456:Retinal Telangiectasis / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D012171:Retinal Vessels / Q000503:physiopathology*; D012189:Retrospective Studies; D014792:Visual Acuity