title: Expression of CA IX in dysplasia adjacent to surgical resection margins of oral squamous cell carcinoma.
abstract: Carbonic anhydrase (CA) IX is a hypoxia marker located almost exclusively in tumor cells. We analyzed the expression of this marker in dysplastic lesions adjacent to the surgical resection margin in patients with oral squamous cell carcinoma. We investigated 70 archived tumors, 36 of which showed dysplasia adjacent to the surgical margin. We used tissue microarray technology to perform an immunohistochemical study of CA IX expression. We found 12 (33.3%) cases of mild dysplasia (10 negative, 2 positive for CA IX), five (13.9%) cases of moderate dysplasia (3 negative, 2 positive for CA IX), 1 (2.8%) case of severe dysplasia (negative for CA IX) and 18 (50%) cases of carcinoma in situ (10 negative, 8 positive for CA IX). In cases of intense expression of CA IX in the tumor, the same distribution of positive and negative cases was observed in all degrees of dysplasia (mild, moderate, severe), although cases of carcinoma in situ tended to be CA IX positive.
authors: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Institute of Sanitary Research of Santiago, (IDIS) , Entrerrios s/n, Santiago de Compostela C.P. 15782.
authors: M
authors: M
authors: Pérez-Sayáns
authors: J M
authors: JM
authors: Suárez-Peñaranda
authors: M
authors: M
authors: Torres-López
authors: C T
authors: CT
authors: Supuran
authors: P
authors: P
authors: Gándara-Vila
authors: P
authors: P
authors: Gayoso-Diz
authors: F
authors: F
authors: Barros-Angueira
authors: A
authors: A
authors: Blanco-Carrión
authors: J M
authors: JM
authors: Gándara-Rey
authors: A
authors: A
authors: García-García
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000235:genetics* / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology; D013194:Staining and Labeling
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases