title: Post-transcriptional controls by ribonucleoprotein complexes in the acquisition of drug resistance.
abstract: Acquisition of drug resistance leads to failure of anti-cancer treatments and therapies. Although several successive chemotherapies are available, along with efforts towards clinical applications of new anti-cancer drugs, it is generally realized that there is a long way to go to treat cancers. Resistance to anti-cancer drugs results from various factors, including genetic as well as epigenetic differences in tumors. Determining the molecular and cellular mechanisms responsible for the acquisition of drug resistance may be a helpful approach for the development of new therapeutic strategies to overcome treatment failure. Several studies have shown that the acquisition of drug resistance is tightly regulated by post-transcriptional regulators such as RNA binding proteins (RBPs) and microRNAs (miRNAs), which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, epithelial-mesenchymal transition, and drug metabolism. Here, we review our current understanding of ribonucleoprotein complexes, including RBPs and miRNAs, which play critical roles in the acquisition of drug resistance and have potential clinical implications for cancer.
authors: Department of Biochemistry, College of Medicine, Catholic University of Korea, Seoul 137-701, Korea. kanghoin1@naver.com
authors: Hoin
authors: H
authors: Kang
authors: Chongtae
authors: C
authors: Kim
authors: Heejin
authors: H
authors: Lee
authors: Wook
authors: W
authors: Kim
authors: Eun Kyung
authors: EK
authors: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D034622:RNA Interference; D020871:RNA Stability; D012261:Ribonucleoproteins / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs; D012261:Ribonucleoproteins
references: Am J Pathol. 2012 Nov;181(5):1823-35
references: 22982443
references: Eur J Cancer. 2010 Aug;46(12):2166-77
references: 20413300
references: Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):217-25
references: 21242194
references: Mol Cancer Res. 2012 Aug;10(8):1098-108
references: 22723308
references: Oncogene. 2013 Jan 17;32(3):341-51
references: 22370637
references: Cancer Res. 2006 Jul 15;66(14):7334-40
references: 16849584
references: Mol Cell Biol. 2007 Sep;27(18):6265-78
references: 17620417
references: Pathol Oncol Res. 2013 Oct;19(4):677-83
references: 23640248
references: Trends Cardiovasc Med. 2003 Jul;13(5):188-95
references: 12837581
references: BMC Cancer. 2013 Feb 08;13:72
references: 23394580
references: Cancer Epidemiol. 2012 Oct;36(5):481-9
references: 22609235
references: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12938-43
references: 19622726
references: Clin Cancer Res. 2006 Apr 15;12(8):2492-7
references: 16638857
references: J Biol Chem. 2008 Oct 31;283(44):29897-903
references: 18708351
references: Genes Dev. 2002 Mar 15;16(6):720-8
references: 11914277
references: Int J Cancer. 2005 Oct 20;117(1):32-40
references: 15880358
references: J Biol Chem. 2012 Feb 10;287(7):4485-91
references: 22199357
references: Mol Cancer. 2010 Apr 30;9:96
references: 20433742
references: Oncotarget. 2012 Nov;3(11):1439-54
references: 23183822
references: Oncogenesis. 2013 Mar 25;2:e40
references: 23552883
references: Mol Cell Biol. 2011 Sep;31(18):3790-801
references: 21768308
references: Science. 2005 Sep 2;309(5740):1514-8
references: 16141059
references: Mol Cancer. 2012 Mar 21;11:13
references: 22436134
references: Biochem J. 2012 Aug 15;446(1):113-23
references: 22646166
references: Cancer Res. 2009 Jun 1;69(11):4567-72
references: 19487279
references: Cancer Res. 2001 Oct 1;61(19):7196-203
references: 11585755
references: Cancer Res. 2008 Feb 1;68(3):826-33
references: 18245484
references: Oncogene. 2012 Jan 5;31(1):39-47
references: 21666713
references: J Gastroenterol. 2012 Aug;47(8):883-95
references: 22382630
references: Biochem J. 2011 Sep 1;438(2):349-58
references: 21649584
references: J Exp Clin Cancer Res. 2009 Feb 15;28:19
references: 19216799
references: Cancer. 1985 May 15;55(10):2303-l6
references: 3886121
references: Nat Rev Mol Cell Biol. 2005 May;6(5):376-85
references: 15852042
references: Pharmacogenomics. 2012 Sep;13(12):1321-4
references: 22966880
references: Mod Pathol. 2009 Dec;22(12):1564-74
references: 19734850
references: EMBO J. 2002 Sep 2;21(17):4709-18
references: 12198173
references: Genes Cancer. 2011 Jul;2(7):720-7
references: 22207897
references: Nat Rev Cancer. 2007 Sep;7(9):713-22
references: 17721435
references: Cancer Res. 2010 Jul 15;70(14):5891-900
references: 20587520
references: Cancer Gene Ther. 2012 Nov;19(11):773-8
references: 22996741
references: J Biol Chem. 2011 Feb 4;286(5):3741-54
references: 21068389
references: J Biol Chem. 1996 Apr 5;271(14):8144-51
references: 8626503
references: Methods Mol Biol. 2010;596:341-58
references: 19949931
references: Mol Pharmacol. 2013 Apr;83(4):857-69
references: 23355539
references: Cancer Gene Ther. 2010 Aug;17(8):523-31
references: 20467450
references: J Cell Physiol. 2006 Jun;207(3):571-81
references: 16250021
references: Mol Cancer Res. 2011 May;9(5):648-59
references: 21498545
references: J Biol Chem. 2001 Nov 2;276(44):40680-6
references: 11546759
references: Front Biosci (Landmark Ed). 2012 Jan 01;17:189-205
references: 22201738
references: Cancer Biol Ther. 2008 Sep;7(9):1496-506
references: 18769129
references: Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):373-80
references: 23519412
references: Clin Cancer Res. 2009 Sep 15;15(18):5615-20
references: 19723648
references: Nat Rev Cancer. 2003 May;3(5):330-8
references: 12724731
references: Br J Cancer. 2006 Apr 24;94(8):1087-92
references: 16495912
references: Drug Resist Updat. 2007 Feb-Apr;10(1-2):59-67
references: 17350322
references: Cell Cycle. 2013 May 1;12(9):1385-94
references: 23574723
references: Nat Rev Mol Cell Biol. 2007 Jun;8(6):479-90
references: 17473849
references: JAMA. 2008 Jan 30;299(4):425-36
references: 18230780
references: J Transl Med. 2010 Aug 20;8:78
references: 20727170
references: FEBS Lett. 2012 May 7;586(9):1279-86
references: 22465665
references: Trends Genet. 2008 Aug;24(8):416-25
references: 18597886
references: Trends Mol Med. 2011 Aug;17(8):412-23
references: 21652264
references: Breast Cancer Res Treat. 2008 Sep;111(1):15-25
references: 17891453
references: RNA Biol. 2011 Jan-Feb;8(1):44-8
references: 21289484
references: Oncol Rep. 2012 Jan;27(1):250-7
references: 21947305
references: Biochemistry. 2010 Aug 10;49(31):6784-90
references: 20614893
references: Oncol Rep. 2011 Oct;26(4):1011-7
references: 21743970
references: Biochem Biophys Res Commun. 2012 Nov 16;428(2):210-5
references: 23036199
references: J Biol Chem. 2013 May 3;288(18):12569-73
references: 23539627
references: Med Oncol. 2011 Mar;28(1):211-8
references: 20143188
references: Int J Mol Sci. 2013 Feb 08;14(2):3802-16
references: 23396109
references: Pharmacogenomics. 2009 Mar;10(3):399-416
references: 19290790
references: IUBMB Life. 2007 Nov;59(11):696-9
references: 17885832
references: Annu Rev Med. 2002;53:615-27
references: 11818492
references: Mol Cancer Ther. 2010 Aug;9(8):2265-75
references: 20647341
references: Nat Rev Drug Discov. 2009 Sep;8(9):709-23
references: 19629074
references: Int J Cancer. 2010 Dec 1;127(11):2520-9
references: 20162574
references: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103
references: 21078976
references: FEBS Lett. 2008 Jun 18;582(14):1977-86
references: 18342629
references: Br J Cancer. 2008 Aug 5;99(3):387-91
references: 18665178
references: Nat Rev Cancer. 2011 Aug 05;11(9):644-56
references: 21822212