title: Predictors of non-adherence to clinical follow-up among patients participating in a randomized trial of pharmaceutical care intervention in HIV-positive adults in Southern Brazil.
abstract: Pharmaceutical care (PC) has been shown to improve adherence to therapeutic interventions as well as improve clinical outcomes. We assessed the predictors of non-adherence to clinical follow-up (i.e., not attending three scheduled routine clinical visits over a 1 year period) among patients who participated in a clinical trial of PC intervention on adherence to HIV antiretroviral therapy uptake (the PC-HIV trial). A total of 332 patients participated: median age was 39 years, 63 % were male, 76 % had CD4 count ≥200 cells/mm³, and 52 % had undetectable viral load. About half, 52.7 %, were non-adherent to clinical follow-up. Identified risk factors for non-adherence were male gender, age <40 years, and being in the trial's "control" group (adjusted odds ratio [AOR] 1.67, 95 % CI 1.05-2.66; AOR 2.21, 95 % CI 1.42-3.47; AOR 1.67, 95 % CI 1.07-2.61, respectively). Younger, male patients may benefit from interventions such as PC, which facilitates engagement in care.
authors: Department of Physiology and Pharmacology, Institute of Biology, Federal University of Pelotas, (UFPel), Campus Universitário, Capão do Leão, S/N, Caixa Postal 354, Pelotas, CEP 96010900, Brazil, marysabelfarmacologia@yahoo.com.br.
authors: Marysabel Pinto Telis
authors: MP
authors: Silveira
authors: Marília Cruz
authors: MC
authors: Guttier
authors: Leila Beltrami
authors: LB
authors: Moreira
authors: Ali
authors: A
authors: Mirzazadeh
authors: Kimberly
authors: K
authors: Page
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001938:Brazil; D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D016017:Odds Ratio; D010593:Pharmaceutical Services / Q000458:organization & administration / Q000706:statistics & numerical data*; D010595:Pharmacists; D011237:Predictive Value of Tests; D024382:Professional Role; D012307:Risk Factors; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents