title: BAF chromatin remodeling complex: cortical size regulation and beyond.
abstract: The multi-subunit chromatin remodeling BAF complex controls different developmental processes. Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume. The mechanistic basis includes suppression of the expression of Pax6 target genes, which are required for genesis of cortical intermediate progenitors (IPs) and specification of late neuronal subtype identity. In addition, we showed that a dynamic competition between BAF170 and BAF155 subunits within the BAF complex during progression of neurogenesis is a primary event in modulating the size of the mammalian cortex. Here, we present additional insights into the interaction between the BAF complex and TF Pax6 in the genesis of IPs of the developing cortex. Furthermore, we show that such competition between BAF170 and BAF155 is involved as well in the determination of the size of the embryonic body. Our results add new insights into a cell-intrinsic mechanism, mediated by the chromatin remodeling BAF complex that controls vertebrate body shape and size.
authors: Institute of Neuroanatomy; Universitätsmedizin Göttingen; Göttingen, Germany.
authors: Tran Cong
authors: TC
authors: Tuoc
authors: Ramanathan
authors: R
authors: Narayanan
authors: Anastassia
authors: A
authors: Stoykova
mesh_terms: D000818:Animals; D049628:Body Size; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D012097:Repressor Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; C000605732:Pax6 protein, mouse; D034741:RNA, Small Interfering; D012097:Repressor Proteins; C491090:Smarcc1 protein, mouse; C587872:Smarcc2 protein, mouse; D014157:Transcription Factors
keywords: BAF complex; Pax6; body size; chromatin regulation; cortical size; intermediate progenitor
references: Nat Rev Neurosci. 2009 Oct;10(10):724-35
references: 19763105
references: Neuron. 1998 Nov;21(5):1031-44
references: 9856459
references: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
references: 14681479
references: Genes Dev. 2008 Jul 15;22(14):1972-86
references: 18628401
references: PLoS Genet. 2009 Jun;5(6):e1000511
references: 19521500
references: Nat Rev Genet. 2013 May;14(5):347-59
references: 23568486
references: Stem Cells. 2008 May;26(5):1155-65
references: 18323406
references: J Cell Sci. 2008 Sep 1;121(Pt 17):2783-93
references: 18716282
references: Cell. 2011 Jul 8;146(1):18-36
references: 21729779
references: Cell. 2013 Apr 25;153(3):535-49
references: 23622239
references: Curr Opin Cell Biol. 2005 Dec;17(6):664-71
references: 16226449
references: Neuron. 2008 Oct 9;60(1):56-69
references: 18940588
references: Neuron. 2003 Mar 6;37(5):751-64
references: 12628166
references: Dev Neurobiol. 2008 Jun;68(7):917-25
references: 18327765
references: Neuron. 2013 Apr 24;78(2):269-84
references: 23622063
references: Nat Neurosci. 2002 Apr;5(4):308-15
references: 11896398
references: Nat Rev Mol Cell Biol. 2005 Oct;6(10):777-88
references: 16314867
references: Curr Opin Neurobiol. 2009 Apr;19(2):120-6
references: 19442513
references: Nat Rev Neurosci. 2002 Jul;3(7):517-30
references: 12094208
references: Genes Dev. 2007 Apr 15;21(8):886-97
references: 17437995
references: Neuron. 2001 Sep 13;31(5):727-41
references: 11567613
references: Trends Neurosci. 1995 Sep;18(9):383-8
references: 7482803
references: Nat Rev Neurosci. 2007 Jun;8(6):427-37
references: 17514196
references: Dev Cell. 2013 May 13;25(3):256-69
references: 23643363
references: J Neurosci. 2009 Jul 1;29(26):8335-49
references: 19571125
references: Nat Rev Neurosci. 2006 Nov;7(11):883-90
references: 17033683
references: Curr Opin Neurobiol. 2012 Oct;22(5):737-46
references: 22554882
references: Cell. 1999 Jan 22;96(2):235-44
references: 9988218
references: Nucleic Acids Res. 1995 Dec 25;23(24):5080-1
references: 8559668
references: Nature. 1959 Oct 24;184:1286-7
references: 13836947
references: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5187-91
references: 19279218
references: Cell. 2007 Sep 21;130(6):1120-33
references: 17889654
references: EMBO J. 1998 Dec 1;17(23):6979-91
references: 9843504
references: Curr Biol. 2012 May 8;22(9):R368-79
references: 22575479
references: Nature. 2007 Feb 22;445(7130):886-91
references: 17259975
references: Neuron. 2007 Jul 19;55(2):201-15
references: 17640523
references: EMBO J. 2004 Jul 21;23(14):2892-902
references: 15229646
references: Blood. 2000 Apr 1;95(7):2446-8
references: 10733521
references: Nat Neurosci. 2009 Oct;12(10):1229-37
references: 19749747
references: Nat Neurosci. 2004 Feb;7(2):136-44
references: 14703572
references: Nat Commun. 2013;4:1665
references: 23575669
references: Prog Neurobiol. 2007 Sep;83(1):37-52
references: 17517461
references: Brain Behav Evol. 2011;78(1):94-107
references: 21691047
references: Cereb Cortex. 2011 Jan;21(1):81-94
references: 20413449
references: EMBO J. 2013 Jul 3;32(13):1817-28
references: 23624932
references: J Neurosci. 2000 Nov 1;20(21):8042-50
references: 11050125
references: Neurobiol Dis. 2010 Jul;39(1):3-12
references: 20304068
references: BMC Dev Biol. 2008 Feb 28;8:23
references: 18307776
references: J Biol Chem. 2008 Sep 5;283(36):24881-8
references: 18611861
references: Dev Biol. 2007 Feb 1;302(1):50-65
references: 16979618