title: Janus nanogels of PEGylated Taxol and PLGA-PEG-PLGA copolymer for cancer therapy.
abstract: Nanogels are promising carriers for the delivery of anti-cancer drugs for cancer therapy. We report in this study on a Janus nanogel system formed by mixing a prodrug of Taxol (PEGylated Taxol) and a copolymer of PLGA-PEG-PLGA. The Janus nanogels have good stability over months in aqueous solutions and the freeze-dried powder of nanogels can be re-dispersed instantly in aqueous solutions. The Janus nanogels show an enhanced inhibition effect on tumor growth in a mice breast cancer model probably due to the enhanced uptake of the nano-sized materials by the EPR effect. What is more, the nanogels can also serve as physical carriers to co-deliver other anti-cancer drugs such as doxorubicin to further improve the anti-cancer efficacy. The results obtained from H&E staining and TUNEL assay also support the observation of tumor growth inhibition. These results suggest the potential of this novel delivery system for cancer therapy.
authors: State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, P. R. China. yangzm@nankai.edu.cn wly@nankai.edu.cn.
authors: Jun
authors: J
authors: Wei
authors: Huaimin
authors: H
authors: Wang
authors: Meifeng
authors: M
authors: Zhu
authors: Dan
authors: D
authors: Ding
authors: Dongxia
authors: D
authors: Li
authors: Zhinan
authors: Z
authors: Yin
authors: Lianyong
authors: L
authors: Wang
authors: Zhimou
authors: Z
authors: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D004359:Drug Therapy, Combination; D005260:Female; D006207:Half-Life; D051379:Mice; D008807:Mice, Inbred BALB C; D000080385:Nanogels; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011098:Polyglactin 910 / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D000080385:Nanogels; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; C413692:polyethylene glycol polyethyleneimine nanogel; D011098:Polyglactin 910; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine; D017239:Paclitaxel