title: Influences of crude extract of tea leaves, Camellia sinensis, on streptozotocin diabetic male albino mice.
abstract: Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for diabetes mellitus. The aim of the present study was to investigate the hypoglycemic activity of the crude tea leaves extract on streptozotocin (STZ)-induced diabetic mice. The average body weight of animals with diabetes and their percentage changes of body weight gain after 15 and 30 days were significantly lower than that of the normal control mice. In diabetic mice, supplementation with tea leaves extract decreased the loss of body weight. After 15 and 30 days, significant increases in the levels of serum glucose, triglycerides, cholesterol, creatinine, urea, uric acid, glutamic pyruvic acid transaminase (GPT) and glutamic oxaloacetic acid transaminase (GOT) were noted in STZ-diabetic mice fed with normal diet. Also, the values of total protein in this group were statistically declined after 15 and 30 days. The levels of serum glucose and GPT were significantly elevated after 15 and 30 days in diabetic mice supplemented with tea leaves extract. Moreover, the level of serum GOT was notably increased after 30 days. Insignificant alterations were observed in the levels of serum triglycerides, cholesterol, total protein, creatinine, urea and uric acid in diabetic mice supplemented with tea leaves extract. Thus, the present results have shown that tea leaves extract has the antihyperglycemic, antihyperlipidemic, and antihyperproteinemic effects and consequently may alleviate liver and kidney damage associated with STZ-induced diabetes in mice.
authors: Department of Biological Sciences, Faculty of Sciences, King Abdul Aziz University, P.O. Box 139109, Jeddah 21323, Saudi Arabia.
authors: Atef M
authors: AM
authors: Al-Attar
authors: Talal A
authors: TA
authors: Zari
keywords: Body weight; Diabetes; Mice; Serum chemistry; Streptozotocin; Tea leaves
references: Biol Pharm Bull. 2008 Jul;31(7):1422-8
references: 18591786
references: Pharmacol Res. 2005 Feb;51(2):117-23
references: 15629256
references: J Ethnopharmacol. 2004 May;92(1):85-91
references: 15099853
references: J Agric Food Chem. 2004 Feb 11;52(3):643-8
references: 14759162
references: J Nutr. 2003 Oct;133(10):3285S-3292S
references: 14519827
references: Indian J Pharm Sci. 2008 Mar-Apr;70(2):227-9
references: 20046718
references: Indian J Exp Biol. 1991 Nov;29(11):1081-3
references: 1816088
references: Br J Nutr. 2009 Dec;102(11):1611-9
references: 19825205
references: J Ethnopharmacol. 2003 Feb;84(2-3):241-5
references: 12648821
references: Biochem Biophys Res Commun. 2010 Jan 1;391(1):733-8
references: 19944074
references: Indian J Pharmacol. 2009 Feb;41(1):19-22
references: 20177576
references: Antimicrob Agents Chemother. 1995 Nov;39(11):2375-7
references: 8585711
references: J Ethnopharmacol. 2000 Sep;72(1-2):69-76
references: 10967456
references: J Ethnopharmacol. 2000 Apr;70(1):9-15
references: 10720784
references: J Ethnopharmacol. 2005 May 13;99(1):75-81
references: 15848023
references: Life Sci. 2005 May 13;76(26):3069-80
references: 15850599
references: Br J Nutr. 2008 Sep;100(3):652-9
references: 18252021
references: Diabetes. 1997 Nov;46(11):1733-42
references: 9356019
references: Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1184-9
references: 17184499
references: Prev Med. 1992 May;21(3):334-50
references: 1614995
references: J Biol Chem. 2001 Aug 17;276(33):31099-104
references: 11390407
references: Phytomedicine. 1995 Oct;2(2):137-89
references: 23196156
references: Can J Physiol Pharmacol. 2010 Feb;88(2):153-60
references: 20237590
references: J Ethnopharmacol. 2007 May 4;111(2):430-4
references: 17197141
references: Diabetes. 1999 Apr;48(4):927-32
references: 10102716
references: Nutr Res. 2008 May;28(5):343-9
references: 19083430
references: Food Chem Toxicol. 2010 Apr;48(4):1078-84
references: 20122979
references: Int J Diabetes Dev Ctries. 2009 Jul;29(3):123-8
references: 20165649
references: Indian J Clin Biochem. 2004 Jul;19(2):23-31
references: 23105452
references: Chem Phys Lipids. 2002 Dec;120(1-2):109-17
references: 12426080
references: Free Radic Biol Med. 2003 Nov 15;35(10):1240-51
references: 14607523