title: Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort.
abstract: Fine particulate matter (PM(2.5)) in air pollution, primarily from combustion sources, is recognized as an important risk factor for cardiovascular events but studies of workplace PM(2.5) exposure are rare. We conducted a prospective study of exposure to PM(2.5) and incidence of ischemic heart disease (IHD) in a cohort of 11,966 US aluminum workers. Incident IHD was identified from medical claims data from 1998 to 2008. Quantitative metrics were developed for recent exposure (within the last year) and cumulative exposure; however, we emphasize recent exposure in the absence of interpretable work histories before follow-up. IHD was modestly associated with recent PM(2.5) overall. In analysis restricted to recent exposures estimated with the highest confidence, the hazard ratio (HR) increased to 1.78 (95% CI: 1.02, 3.11) in the second quartile and remained elevated. When the analysis was stratified by work process, the HR rose monotonically to 1.5 in both smelter and fabrication facilities, though exposure was almost an order of magnitude higher in smelters. The differential exposure-response may be due to differences in exposure composition or healthy worker survivor effect. These results are consistent with the air pollution and cigarette smoke literature; recent exposure to PM(2.5) in the workplace appears to increase the risk of IHD incidence.
authors: Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA.
authors: Sadie
authors: S
authors: Costello
authors: Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA.
authors: Daniel M
authors: DM
authors: Brown
authors: Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA.
authors: Elizabeth M
authors: EM
authors: Noth
authors: Occupational and Environmental Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
authors: Linda
authors: L
authors: Cantley
authors: Occupational and Environmental Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
authors: Martin D
authors: MD
authors: Slade
authors: Occupational and Environmental Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA.
authors: Baylah
authors: B
authors: Tessier-Sherman
authors: Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA.
authors: S Katharine
authors: SK
authors: Hammond
authors: Environmental Health Science, School of Public Health, University of California, Berkeley, California, USA.
authors: Ellen A
authors: EA
authors: Eisen
authors: Department of Internal Medicine, Stanford University, Stanford, California, USA.
authors: Mark R
authors: MR
authors: Cullen
mesh_terms: D000368:Aged; D000535:Aluminum / Q000009:adverse effects*; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D052638:Particulate Matter; D000535:Aluminum
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