title: Copper-catalyzed synthesis of benzo[b]thiophenes and benzothiazoles using thiocarboxylic acids as a coupling partner.
abstract: An efficient copper-catalyzed approach to benzo[b]thiophene and benzothiazole derivatives using thiocarboxylic acids as a sulfur source has been developed. In the presence of CuI and 1,10-phen, and n-Pr3N as the base, (2-iodobenzyl)triphenylphosphonium bromide and (2-iodophenylimino)triphenylphosphorane reacted smoothly with thiocarboxylic acids to give benzo[b]thiophene and benzothiazole derivatives in good yields via sequential Ullmann-type C-S bond coupling and Wittig condensation.
authors: Department of Chemistry, Tongji University, 1239 Siping Road, Yangpu, Shanghai 200092, PR China. yuhui@tongji.edu.cn
authors: Hui
authors: H
authors: Yu
authors: Meishu
authors: M
authors: Zhang
authors: Yuzhe
authors: Y
authors: Li
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D002264:Carboxylic Acids; D013438:Sulfhydryl Compounds; D013876:Thiophenes; C088015:benzothiophene; D003300:Copper