title: The role of smooth muscle cells in the pathophysiology of pelvic organ prolapse.
abstract: Pelvic organ prolapse (POP) is a prevalent and disabling condition. The pathophysiology of prolapse is multifactorial, and no single mechanism adequately explains all aspects of its development. The pathophysiology of POP is complex and incompletely understood. Smooth muscle (SM), an integral part of the vaginal wall and endopelvic structures that support the pelvic viscera, has also been implicated in the pathophysiology of POP. In this article, we review the role of smooth muscle cells (SMC) in the pathophysiology of POP, also addressing the anatomy of SM in pelvic floor, morphometric analysis, biomechanical properties, and potential mechanisms.
authors: Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors: Shanshan
authors: S
authors: Mei
authors: Ming
authors: M
authors: Ye
authors: Laura
authors: L
authors: Gil
authors: Jianping
authors: J
authors: Zhang
authors: Yanping
authors: Y
authors: Zhang
authors: Keith
authors: K
authors: Candiotti
authors: Peter
authors: P
authors: Takacs
mesh_terms: D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000473:pathology / Q000502:physiology*; D017773:Pelvic Floor / Q000473:pathology / Q000503:physiopathology*; D056887:Pelvic Organ Prolapse / Q000209:etiology / Q000503:physiopathology*