title: Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features.
abstract: OBJECTIVE
  Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression.
  
  
  METHODS
  A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients.
  
  
  RESULTS
  There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression.
  
  
  CONCLUSIONS
  These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.
authors: Zeynep
authors: Z
authors: Kotan
authors: Emre
authors: E
authors: Sarandöl
authors: Emine
authors: E
authors: Kırhan
authors: Güven
authors: G
authors: Ozkaya
authors: Selcçuk
authors: S
authors: Kırlı
keywords: brain-derived neurotrophic factor; depression; leptin; vascular endothelial growth factor
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