title: Association between genetic polymorphisms of beta2 adrenergic receptors and nocturnal asthma in Egyptian children.
abstract: BACKGROUND
  Identification of the genetic basis of asthma may contribute to the discovery of effective asthma drugs.
  
  
  OBJECTIVE
  Our aim was to estimate the association between B2 adrenergic receptor (ADRB2) polymorphisms and nocturnal asthma in Egyptian children.
  
  
  METHODS
  ADRB2 polymorphisms Gly16 and Glu27 were genotyped in 200 Egyptian children (90 with nocturnal asthma and 110 healthy controls) using allele-specific polymerase chain reaction.
  
  
  RESULTS
  The homozygous (Gly16) genotype significantly increased the risk of nocturnal asthma (odds ratio [OR], 3.2; 95% CI, 1.3-7.7; P = .003), as did the Gly allele (OR, 1.8: 95% CI, 1.2-2.8).
  
  
  CONCLUSIONS
  Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.
authors: Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors: R A
authors: RA
authors: Karam
authors: N A
authors: NA
authors: Sabbah
authors: H E
authors: HE
authors: Zidan
authors: H M A
authors: HM
authors: Rahman
mesh_terms: D000293:Adolescent; D000483:Alleles; D019943:Amino Acid Substitution; D001249:Asthma / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D004534:Egypt; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: C553443:ADRB2 protein, human; D018343:Receptors, Adrenergic, beta-2