title: Palladium-catalyzed cyclization of bromoenynamides to tricyclic azacycles: synthesis of trikentrin-like frameworks.
abstract: Palladium-catalyzed cascade cyclization of bromoenynamides equipped with an additional alkyne or ynamide substituent affords azatricyclic products. Using 5- to 7-membered ring tethers, this chemistry offers a regiospecific route to highly-functionalized azacycles. Elaboration to the trikentrin B skeleton is achieved from the arylsilane cyclization products.
authors: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. edward.anderson@chem.ox.ac.uk.
authors: Craig D
authors: CD
authors: Campbell
authors: Rebecca L
authors: RL
authors: Greenaway
authors: Oliver T
authors: OT
authors: Holton
authors: Helen A
authors: HA
authors: Chapman
authors: Edward A
authors: EA
authors: Anderson
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000577:Amides; D053961:Azabicyclo Compounds; D006842:Hydrocarbons, Brominated; D026121:Indole Alkaloids; C519345:trikentrin A; D010165:Palladium