title: PharmGKB summary: tamoxifen pathway, pharmacokinetics.
authors: Departments of aGenetics bBioengineering, Stanford University Medical Center, Stanford, California cDepartment of Medicine, Indiana University Simon Cancer Center, Indianapolis, Indiana, USA.
authors: Daniel J
authors: DJ
authors: Klein
authors: Caroline F
authors: CF
authors: Thorn
authors: Zeruesenay
authors: Z
authors: Desta
authors: David A
authors: DA
authors: Flockhart
authors: Russ B
authors: RB
authors: Altman
authors: Teri E
authors: TE
authors: Klein
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015239:Arylsulfotransferase / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D010597:Pharmacogenetics; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D013629:Tamoxifen / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen; D013629:Tamoxifen; D019389:Cytochrome P-450 CYP2D6; D015239:Arylsulfotransferase
references: J Natl Cancer Inst. 2012 Mar 21;104(6):441-51
references: 22395644
references: J Pharmacol Exp Ther. 2011 Jun;337(3):710-7
references: 21378205
references: Oncologist. 2012;17(5):620-30
references: 22531359
references: Pharmacogenomics. 2011 Nov;12(11):1535-43
references: 21961651
references: Drug Metab Dispos. 2011 Mar;39(3):558-62
references: 21148080
references: Drug Metab Dispos. 2005 Oct;33(10):1446-52
references: 15987777
references: J Clin Oncol. 2007 Sep 1;25(25):3837-45
references: 17761971
references: J Clin Oncol. 2007 Nov 20;25(33):5187-93
references: 18024866
references: Breast Cancer Res. 2007;9(1):R7
references: 17244352
references: Breast Cancer Res. 2005;7(3):R284-90
references: 15987423
references: Breast Cancer Res Treat. 2005 Jun;91(3):249-58
references: 15952058
references: J Clin Oncol. 2006 Aug 1;24(22):3708-9; author reply 3709
references: 16877740
references: N Engl J Med. 1998 Nov 26;339(22):1609-18
references: 9828250
references: Nat Clin Pract Oncol. 2007 Mar;4(3):152-3
references: 17245346
references: Clin Pharmacol Ther. 2011 May;89(5):708-17
references: 21451508
references: Breast Cancer Res Treat. 2012 May;133(1):99-109
references: 21814747
references: Breast Cancer Res Treat. 2009 May;115(2):391-6
references: 18521743
references: Hum Mol Genet. 2012 Apr 1;21(7):1665-72
references: 22180457
references: J Natl Cancer Inst. 1998 Sep 16;90(18):1371-88
references: 9747868
references: Br J Pharmacol. 1980;71(1):83-91
references: 7470748
references: J Natl Cancer Inst. 2003 Dec 3;95(23):1734-5
references: 14652227
references: Drug Metab Dispos. 2007 Nov;35(11):2006-14
references: 17664247
references: J Clin Oncol. 2010 Mar 10;28(8):1287-93
references: 20124171
references: Nat Rev Drug Discov. 2003 Mar;2(3):205-13
references: 12612646
references: J Natl Cancer Inst. 2012 Mar 21;104(6):452-60
references: 22395643
references: J Natl Cancer Inst. 2005 Jan 5;97(1):30-9
references: 15632378
references: J Clin Oncol. 2013 Jan 10;31(2):176-80
references: 23091108
references: JAMA. 2009 Oct 7;302(13):1429-36
references: 19809024
references: Pharmacogenet Genomics. 2009 Jul;19(7):559-62
references: 19512959
references: Nature. 1975 Aug 14;256(5518):592-3
references: 170527
references: Pharmacogenomics. 2012 Jun;13(8):951-4
references: 22676198
references: J Endocrinol. 1977 Nov;75(2):305-16
references: 591813
references: J Natl Cancer Inst. 2003 Dec 3;95(23):1758-64
references: 14652237
references: Breast Cancer Res Treat. 2012 Jan;131(2):473-81
references: 21390495
references: Lancet. 1989 Jan 21;1(8630):117-20
references: 2563046
references: Drug Metab Dispos. 2006 Mar;34(3):361-8
references: 16381672
references: Drug Metab Pharmacokinet. 2012;27(1):122-31
references: 22041137
references: Carcinogenesis. 2000 Oct;21(10):1851-8
references: 11023543
references: Breast Cancer Res Treat. 2012 Jul;134(2):693-700
references: 22562123
references: Am J Psychiatry. 2008 Oct;165(10):1251-5
references: 18829880
references: Cancer Res. 1988 Apr 15;48(8):2304-8
references: 3349495
references: Breast Cancer Res Treat. 2007 Jan;101(1):113-21
references: 17115111
references: J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75
references: 15159443
references: J Natl Cancer Inst. 2012 Aug 22;104(16):1264; author reply 1266-8
references: 22851270
references: Cancer Res. 2009 Mar 1;69(5):1722-7
references: 19244106
references: J Natl Cancer Inst. 2002 Nov 6;94(21):1635-40
references: 12419790
references: BMC Cancer. 2010 Jun 21;10:313
references: 20565970
references: J Natl Cancer Inst. 2012 Aug 22;104(16):1265-6; author reply 1266-8
references: 22851267
references: Clin Pharmacol Ther. 2006 Jul;80(1):61-74
references: 16815318
references: Eur J Cancer. 1975 Mar;11(3):205-6
references: 165942
references: J Clin Oncol. 2005 Dec 20;23(36):9312-8
references: 16361630