title: Quality of life in immune thrombocytopenia following treatment.
abstract: OBJECTIVE
  To determine the impact of therapy on the reported health-related quality of life (HRQoL) in children with primary immune thrombocytopenia (ITP) using the Kids ITP tool (KIT).
  
  
  METHODS
  Secondary data analysis of the international and North American KIT validation studies.
  
  
  RESULTS
  217 children from 6 countries participated in the two studies. The majority of treatments occurred in children with newly diagnosed ITP. There was no statistical difference in age, platelet count and bleeding severity at presentation in those who physicians chose to treat or observe. Self-reported KIT scores did not differ between the two groups. The KIT parent-proxy scores were significantly worse for newly diagnosed children receiving treatment, especially following prednisone.
  
  
  CONCLUSIONS
  Treatment of ITP does not improve, and may worsen, the HRQoL of children with ITP as measured using the KIT.
authors: Department of Haematology, University of Manchester, Royal Manchester Children's Hospital, , Manchester, UK.
authors: John D
authors: JD
authors: Grainger
authors: Nancy L
authors: NL
authors: Young
authors: Victor S
authors: VS
authors: Blanchette
authors: Robert J
authors: RJ
authors: Klaassen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007518:Isoantibodies / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011594:Psychometrics; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000534:rehabilitation*; D011788:Quality of Life; D018029:Rho(D) Immune Globulin; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin; D011241:Prednisone
keywords: General Paediatrics; Haematology; ITP; quality of life