title: Palladium-catalyzed hydrobenzylation of ortho-tolyl alkynyl ethers by benzylic C-H activation: remarkable alkynoxy-directing effect.
abstract: It's selective: The title reaction involves palladium(0)-catalyzed insertion of C≡C bonds into benzylic C(sp(3))-H bonds, thus providing efficient access to 2-methylene-2,3-dihydrobenzofurans, which transform into benzofurans upon treatment with a weak acid (e.g., AcOH) and electrophiles. The alkynoxy group serves as a directing group in promoting C-H bond functionalization.
authors: Research and Development Initiative, Chuo University, JST, ACT-C, Kasuga, Bunkyo-ku, Tokyo 112-8551 (Japan). yminami@kc.chuo-u.ac.jp.
authors: Yasunori
authors: Y
authors: Minami
authors: Kotomi
authors: K
authors: Yamada
authors: Tamejiro
authors: T
authors: Hiyama
keywords: alkynes; arenes; heterocycles; palladium; synthetic methods