title: Serum MMP-8: a novel indicator of left ventricular remodeling and cardiac outcome in patients after acute myocardial infarction.
abstract: OBJECTIVE
  Left ventricular (LV) remodeling following myocardial infarction (MI) is characterized by progressive alterations of structure and function, named LV remodeling. Although several risk factors such as infarct size have been identified, LV remodeling remains difficult to predict in clinical practice. Changes within the extracellular matrix, involving matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), are an integral part of left ventricular (LV) remodeling after myocardial infarction (MI). We investigated the temporal profile of circulating MMPs and TIMPs and their relations with LV remodeling at 1 year and clinical outcome at 3 years in post-MI patients.
  
  
  METHODS
  This prospective multicentre study included 246 patients with a first anterior MI. Serial echocardiographic studies were performed at hospital discharge, 3 months, and 1 year after MI, and analysed at a core laboratory. LV remodeling was defined as the percent change in LV end-diastolic volume (EDV) from baseline to 1 year. Serum samples were obtained at hospital discharge, 1, 3, and 12 months. Multiplex technology was used for analysis of MMP-1, -2, -3, -8, -9, -13, and TIMP-1, -2, -3, -4 serum levels.
  
  
  RESULTS
  Baseline levels of MMP-8 and MMP-9 were positively associated with changes in LVEDV (P = 0.01 and 0.02, respectively). When adjusted for major baseline characteristics, MMP-8 levels remained an independent predictor LV remodeling (P = 0.025). By univariate analysis, there were positive relations between cardiovascular death or hospitalization for heart failure during the 3-year follow-up and the baseline levels of MMP-2 (P = 0.03), MMP-8 (P = 0.002), and MMP-9 (P = 0.03). By multivariate analysis, MMP-8 was the only MMP remaining significantly associated with clinical outcome (P = 0.02).
  
  
  CONCLUSIONS
  Baseline serum MMP-8 is a significant predictor of LV remodeling and cardiovascular outcome after MI and may help to improve risk stratification.
authors: Centre Hospitalier Régional et Universitaire de Lille, Lille, France.
authors: Marie
authors: M
authors: Fertin
authors: Gilles
authors: G
authors: Lemesle
authors: Annie
authors: A
authors: Turkieh
authors: Olivia
authors: O
authors: Beseme
authors: Maggy
authors: M
authors: Chwastyniak
authors: Philippe
authors: P
authors: Amouyel
authors: Christophe
authors: C
authors: Bauters
authors: Florence
authors: F
authors: Pinet
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D004562:Electrocardiography; D023381:Endpoint Determination; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology*; D011379:Prognosis; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D019714:Tissue Inhibitor of Metalloproteinases; D020784:Matrix Metalloproteinase 8
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