title: Self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in the presence of mixed nonionic surfactants.
abstract: The present study was undertaken to evaluate the impact of various combinations of nonionic surfactants on self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in glibenclamide (GBN) nanoemulsion. Formulations (L1-L30) were prepared by spontaneous emulsification method. Prepared formulations were subjected to thermodynamic stability and self-nanoemulsification test. Results of thermodynamic stability and self-nanoemulsification tests were confirmed by further characterization of these formulations in terms of droplet size, viscosity, refractive index and % transmittance. Formulations prepared with Labrasol, HCO-60 and Gelucire-44/14 were found to be suitable for self-emulsifying drug delivery system only whereas those prepared with Tween-80 and Cremophor-EL were found to be suitable for self-nanoemulsifying or self-microemulsifying drug delivery system of GBN with respect to Lauroglycol-90 or Lauroglycol-FCC. Formulation L24 (Lauroglycol-FCC/Tween-80/ethanol/water) was optimized as best formulation for self-nanoemulsifying drug delivery system of GBN. These results indicated that Tween-80 could be the best surfactant in terms of self-nanoemulsification.
authors: Center of Excellence in Biotechnology Research, King Saud University , P.O. Box 2460, Riyadh 11451 , Saudi Arabia .
authors: Faiyaz
authors: F
authors: Shakeel
authors: Nazrul
authors: N
authors: Haq
authors: Fars K
authors: FK
authors: Alanazi
authors: Ibrahim A
authors: IA
authors: Alsarra
mesh_terms: D045703:Emulsifying Agents / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D005905:Glyburide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D007848:Laurates / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D045703:Emulsifying Agents; D004655:Emulsions; D007004:Hypoglycemic Agents; D007848:Laurates; D011409:Propylene Glycols; D013501:Surface-Active Agents; C098387:propyleneglycol monolaurate; D005905:Glyburide