title: Correlation between different Chinese medicine syndromes and changes in microcirculation in septic shock patients.
abstract: OBJECTIVE
  To investigate the correlation between different Chinese medicine (CM) syndromes and variations in microcirculation in septic shock patients.
  
  
  METHODS
  seventy Septic shock patients were divided into four groups: heat damaging qi-yin group (HDQY, 23 cases); yin exhaustion and yang collapse group (YEYC, 26 cases); excessive heat in Fu organ group (EHFO, 10 cases); and heat damaging nutrient-blood group (HDNB, 11 cases). Sublingual microcirculation parameters were observed by sidestream dark-field (SDF) imaging and scored by Acute Physiology and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA), and parameters of microcirculation perfusion variations and prognoses were analyzed.
  
  
  RESULTS
  Compared with those with qi-yin heat damage, perfused vessel density (PVD) in other groups decreased dramatically (P<0.05), and APACHE II scores increased significantly (P<0.05). In addition, the recovery time was prolonged substantially (P<0.05), and the mixed venous oxygen saturation (SVO2) decreased (P<0.05). Blood lactic acid increased significantly (P<0.05), and the mixed SVO decreased (P<0.05), in the YEYC group. Compared with the thermal injury camp blood group, sublingual microcirculation parameter variations showed no obvious difference in the YEYC and EHFO groups (P>0.05). There were significant positive correlations between CM syndromes and APACHE II scoring in different groups (r=0.512, P<0.05). There were negative correlations between PVD and APACHE II scoring (r=-0.378, P=0.043), the proportion of perfused vessels (PPV) and APACHE II scoring (r=-0.472, P=0.008), as well as between the microvascular flow index (MFI) and APACHE II scoring (r=-0.424, P=0.023) in different patients.
  
  
  CONCLUSIONS
  Sublingual microcirculation may serve as a clinical diagnostic parameter of the patient condition, as well as being a prognostic indicator.
authors: Department of Critical Care Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, 100050, Beijing, China.
authors: Jing-feng
authors: JF
authors: Liu
authors: Meng-ya
authors: MY
authors: Zhao
authors: Hai-zhou
authors: HZ
authors: Zhuang
authors: Chong
authors: C
authors: Liu
authors: Yi-bing
authors: YB
authors: Weng
authors: Ang
authors: A
authors: Li
authors: Shu-wen
authors: SW
authors: Zhang
authors: Mei-li
authors: ML
authors: Duan
mesh_terms: D000368:Aged; D004298:Dopamine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D009060:Mouth Floor / Q000098:blood supply* / Q000503:physiopathology*; D010477:Perfusion; D012772:Shock, Septic / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D013577:Syndrome
chemical_list: D004298:Dopamine
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