title: Poly(2-oxazoline)s as materials for biomedical applications.
abstract: The conjunction of polymers and medicine enables the development of new materials that display novel features, opening new ways to administrate drugs, design implants and biosensors, to deliver pharmaceuticals impacting cancer treatment, regenerative medicine or gene therapy. Poly(2-oxazoline)s (POx) constitute a polymer class with exceptional properties for their use in a plethora of different biomedical applications and are proposed as a versatile platform for the development of new medicine. Herein, a global vision of POx as a platform for novel biomaterials is offered, by highlighting the recent advances and breakthroughs in this fascinating field.
authors: Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281-S4, 9000, Ghent, Belgium, victor.retamerodelarosa@ugent.be.
authors: Victor R
authors: VR
authors: de la Rosa
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D010080:Oxazoles / Q000737:chemistry*; D019736:Prostheses and Implants; D023822:Tissue Engineering / Q000295:instrumentation*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D010080:Oxazoles; C577913:poly(2-oxazoline)
references: J Comb Chem. 2005 Jan-Feb;7(1):10-3
references: 15638473
references: Bioconjug Chem. 1994 Nov-Dec;5(6):493-6
references: 7873652
references: Adv Drug Deliv Rev. 2007 Dec 22;59(15):1504-20
references: 17904246
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1599
references: 22965791
references: J Control Release. 2012 Sep 10;162(2):446-55
references: 22820448
references: Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5679-84
references: 15824322
references: Angew Chem Int Ed Engl. 2009;48(43):7978-94
references: 19768817
references: Macromol Biosci. 2009 Feb 11;9(2):157-61
references: 19009514
references: Angew Chem Int Ed Engl. 2006 Feb 13;45(8):1198-215
references: 16444775
references: Biotechnol Bioeng. 2004 Mar 20;85(6):629-37
references: 14966804
references: J Control Release. 2007 Jun 22;119(3):291-300
references: 17451833
references: Cancer Sci. 2009 Apr;100(4):572-9
references: 19462526
references: Macromol Rapid Commun. 2011 Nov 15;32(22):1815-9
references: 21932286
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1701-7
references: 22893256
references: Biomaterials. 2011 Aug;32(22):5291-303
references: 21514664
references: Mol Pharm. 2010 Aug 2;7(4):984-92
references: 20550191
references: J Control Release. 2008 Jan 22;125(2):87-95
references: 18031860
references: J Control Release. 2012 May 10;159(3):353-61
references: 22405905
references: Bioconjug Chem. 2011 May 18;22(5):976-86
references: 21452890
references: Bioconjug Chem. 2003 May-Jun;14(3):581-7
references: 12757382
references: Science. 1999 Dec 17;286(5448):2244-5
references: 10636774
references: Adv Drug Deliv Rev. 2012 Jun 15;64(9):836-51
references: 22342438
references: Adv Mater. 2010 Mar 26;22(12):1412-6
references: 20333690
references: Adv Drug Deliv Rev. 2013 Jan;65(1):60-70
references: 22981753
references: J Control Release. 2001 Jun 15;73(2-3):391-9
references: 11516514
references: Bioconjug Chem. 2001 Nov-Dec;12(6):989-94
references: 11716690
references: Angew Chem Int Ed Engl. 1966 Oct;5(10):875-88
references: 4962631
references: Biomacromolecules. 2012 Jan 9;13(1):40-8
references: 22145634
references: Biomaterials. 2010 Dec;31(36):9462-72
references: 21059465
references: Eur J Pharm Sci. 2012 Apr 11;45(5):539-45
references: 22155543
references: Chem Commun (Camb). 2008 Nov 30;(44):5758-60
references: 19009072
references: Macromol Biosci. 2005 Feb 23;5(2):149-56
references: 15719430
references: Nat Rev Drug Discov. 2008 Jan;7(1):21-39
references: 18097458
references: Curr Opin Biotechnol. 2011 Aug;22(4):492-501
references: 21676609
references: Macromol Biosci. 2012 Jul;12(7):986-98
references: 22648985
references: Macromol Biosci. 2012 Jul;12(7):926-36
references: 22610725
references: Int J Pharm. 2012 Oct 15;436(1-2):636-43
references: 22850293
references: Mol Immunol. 2008 Dec;46(2):225-32
references: 18849076
references: Chem Commun (Camb). 2011 Oct 14;47(38):10620-2
references: 21881646
references: Macromol Biosci. 2011 Jan 10;11(1):111-21
references: 20945436
references: Biointerphases. 2012 Dec;7(1-4):1
references: 22589044
references: ACS Appl Mater Interfaces. 2011 Sep;3(9):3463-71
references: 21834589
references: Biotechnol J. 2010 Jan;5(1):113-28
references: 20069580
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1663-76
references: 22996913
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1632-47
references: 22811405
references: J Mater Sci Mater Med. 2011 Jul;22(7):1725-34
references: 21604137
references: Biomaterials. 2010 Jun;31(18):4972-9
references: 20346493
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1600-12
references: 22760956
references: Acta Biomater. 2011 Dec;7(12):4149-59
references: 21810488
references: Mol Pharm. 2012 Aug 6;9(8):2302-13
references: 22681126
references: Adv Drug Deliv Rev. 2012 Jun 15;64(9):866-84
references: 22349241
references: Beilstein J Org Chem. 2010 Sep 09;6:773-83
references: 20978618
references: J Cardiovasc Pharmacol. 2008 Mar;51(3):246-52
references: 18356688
references: ACS Appl Mater Interfaces. 2012 Mar;4(3):1357-64
references: 22324756
references: Adv Colloid Interface Sci. 1998 Feb;74:69-117
references: 9561719
references: Nat Mater. 2009 Jun;8(6):451-3
references: 19458644
references: Adv Drug Deliv Rev. 2003 Sep 26;55(10):1261-77
references: 14499706
references: J Pediatr. 1988 Aug;113(2):312-7
references: 3260944
references: Eur J Pharm Biopharm. 2012 Aug;81(3):506-13
references: 22580209
references: J Control Release. 2011 Jul 15;153(1):73-82
references: 21513750
references: Biomaterials. 2008 Aug-Sep;29(24-25):3477-96
references: 18499247
references: Langmuir. 2008 Feb 5;24(3):613-6
references: 18179272
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1648-62
references: 23034926
references: Nature. 2001 Dec 13;414(6865):677
references: 11742355
references: N Engl J Med. 2009 Aug 20;361(8):787-94
references: 19692690
references: J Gene Med. 2005 Oct;7(10):1287-98
references: 15906395
references: Biomacromolecules. 2012 Jan 9;13(1):165-72
references: 22148422
references: Nano Lett. 2008 May;8(5):1368-73
references: 18444692
references: Nano Lett. 2005 Nov;5(11):2220-4
references: 16277457
references: Nat Biotechnol. 1999 Jan;17(1):94-5
references: 9920278
references: Macromol Biosci. 2009 Feb 11;9(2):129-39
references: 19107717
references: Macromol Biosci. 2011 Dec 8;11(12):1621-4
references: 22110007
references: Bioconjug Chem. 2006 May-Jun;17(3):781-6
references: 16704218
references: J Control Release. 2012 Jul 20;161(2):473-83
references: 22020381
references: Nature. 2002 Nov 14;420(6912):116-8
references: 12432357
references: J Control Release. 2012 Jul 20;161(2):461-72
references: 22094104
references: Nat Rev Drug Discov. 2003 May;2(5):347-60
references: 12750738
references: J Biomed Mater Res B Appl Biomater. 2005 May;73(2):347-54
references: 15736286
references: Curr Opin Biotechnol. 2011 Dec;22(6):894-900
references: 21724381
references: Biomaterials. 2008 Feb;29(5):551-60
references: 17981322
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1677-82
references: 22619208
references: Macromol Biosci. 2012 Aug;12(8):1114-23
references: 22777761
references: J Pharm Sci. 1996 Feb;85(2):133-7
references: 8683436
references: Biochim Biophys Acta. 2004 Jun 28;1689(2):103-13
references: 15196591
references: Cancer. 2007 Jul 1;110(1):103-11
references: 17516438
references: Macromol Rapid Commun. 2010 Mar 16;31(6):511-25
references: 21590935
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1613-31
references: 22865555
references: J Control Release. 2010 Mar 3;142(2):160-6
references: 19850094
references: Angew Chem Int Ed Engl. 2004 Feb 20;43(9):1064-76
references: 14983439
references: Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308
references: 20648499
references: Langmuir. 2010 May 4;26(9):6529-34
references: 20035571
references: Macromol Rapid Commun. 2012 Oct 15;33(19):1695-700
references: 22887564
references: Adv Drug Deliv Rev. 2009 Nov 12;61(13):1203-13
references: 19699247