title: The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test.
abstract: BACKGROUND
  There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects.
  
  
  OBJECTIVE
  We examined the relationship between 17β-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST).
  
  
  METHODS
  Topiramate was administered alone or combined with 17β-estradiol to ovariectomized rats submitted to the FST.
  
  
  RESULTS
  Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17β-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17β-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17β-estradiol (P < 0.05) reduced locomotion.
  
  
  CONCLUSIONS
  Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.
authors: Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México, mimolis@hotmail.com.
authors: Miguel
authors: M
authors: Molina-Hernández
authors: N Patricia
authors: NP
authors: Téllez-Alcántara
authors: Jorge I
authors: JI
authors: Olivera-López
authors: M Teresa
authors: MT
authors: Jaramillo
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010052:Ovariectomy / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology; D000077236:Topiramate
chemical_list: D000928:Antidepressive Agents; D000077236:Topiramate; D005632:Fructose; D004958:Estradiol
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