title: Green synthesis of α-aminophosphonate derivatives on a solid supported TiO2 -SiO2 catalyst and their anticancer activity.
abstract: Syntheses of a new series of biologically potent α-aminophosphonates were accomplished by one-pot Kabachnik-Fields reaction using TiO2-SiO2 as solid supported catalyst under microwave irradiation conditions. The chemical structures of all the newly synthesized compounds were confirmed by analytical and spectral (IR, 1H, 13C, 31P NMR, and mass) data. Their anticancer nature was evaluated by screening the in vitro activity on two human cancer cell lines, HeLa and SK-BR-3. Compounds 4i and 4o showed the best activity on these cancer cells even though the majority of the compounds, and particularly 4l and 4p, have good cytotoxic activity against them.
authors: Department of Chemistry, Sri Venkateswara University, Tirupati, Andra Pradesh, India.
authors: Radha Rani
authors: RR
authors: Chinthaparthi
authors: Ira
authors: I
authors: Bhatnagar
authors: Chandra Sekhar Reddy
authors: CS
authors: Gangireddy
authors: Sundar Chereddy
authors: SC
authors: Syama
authors: Suresh Reddy
authors: SR
authors: Cirandur
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D055772:Green Chemistry Technology / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry; D013329:Structure-Activity Relationship; D014025:Titanium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium
keywords: Anticancer activity; Green synthesis; HeLa and SK-BR-3 human cancer cells; TiO2-SiO2; α-Aminophosphonates