title: Asymmetric α-arylation of amino acid derivatives by Clayden rearrangement of ester enolates via memory of chirality.
abstract: A method for asymmetric α-arylation of amino acid derivatives has been developed. The arylation was performed by Clayden rearrangement of ester enolates via memory of chirality to give hydantoins with an aryl-substituted tetrasubstituted carbon with up to 99% ee.
authors: Institute for Chemical Research, Kyoto University , Uji, Kyoto 611-0011, Japan.
authors: Keisuke
authors: K
authors: Tomohara
authors: Tomoyuki
authors: T
authors: Yoshimura
authors: Ryuichi
authors: R
authors: Hyakutake
authors: Pan
authors: P
authors: Yang
authors: Takeo
authors: T
authors: Kawabata
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D004952:Esters; D007659:Ketones