title: Blood chemical changes and renal histological alterations induced by gentamicin in rats.
abstract: Gentamicin is an effective widely used antibiotic, but the risk of nephrotoxicity and oxidative damage limit its long-term use. Hence, the current study aims to elucidate such hazardous effects. To achieve the study aim male Wistar albino rats (Rattus norvegicus) were exposed to gentamicin to investigate the resultant blood chemical changes and renal histological alterations. In comparison with control rats, gentamicin produced outstanding tubular, glomerular and interstitial alterations that included degeneration, necrosis, cytolysis and cortical tubular desquamation together with mesangial hypercellularity, endothelial cell proliferation and blood capillary congestion. Compared with control animals significant blood chemical changes (P < 0.05) including free radicals, ALT, AST, ALP, serum creatinine and serum urea were recorded in gentamicin-injected animals. The findings revealed that exposure to gentamicin can induce significant histological alterations in the kidney as well as remarkable blood chemical changes that might indicate marked renal failure.
authors: Department of Zoology, Faculty of Science, King Saud University, Saudi Arabia.
authors: Saud
authors: S
authors: Alarifi
authors: Amin
authors: A
authors: Al-Doaiss
authors: Saad
authors: S
authors: Alkahtani
authors: S A
authors: SA
authors: Al-Farraj
authors: Mohammed Saad
authors: MS
authors: Al-Eissa
authors: B
authors: B
authors: Al-Dahmash
authors: Hamad
authors: H
authors: Al-Yahya
authors: Mohammed
authors: M
authors: Mubarak
keywords: Creatinine; Free radicals; Gentamicin; Histopathology; Nephrotoxicity; Rattus norvegicus; Transaminases; Tubular necrosis; Urea
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