title: HIV and innate immunity - a genomics perspective.
abstract: Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied. A clearer semantic classification of the components of innate immunity is needed, which will have direct relevance to the interpretation of human genome variation. Here, we discuss genomic approaches that can assist in re-defining the perimeter of innate immunity. We place particular emphasis on the characteristics of effectors of the intracellular defense against HIV and other pathogens.
authors: Institute of Microbiology, University Hospital of Lausanne and University of Lausanne Switzerland ; Swiss Institute of Bioinformatics, Lausanne Switzerland.
authors: Antonio
authors: A
authors: Rausell
authors: Paul J
authors: PJ
authors: McLaren
authors: Amalio
authors: A
authors: Telenti
references: Nature. 2012 Nov 1;491(7422):56-65
references: 23128226
references: Nat Immunol. 2007 Nov;8(11):1165-71
references: 17952041
references: Science. 2013 Apr 12;340(6129):202-7
references: 23580528
references: Nat Genet. 2000 May;25(1):25-9
references: 10802651
references: Science. 2013 May 10;340(6133):701-6
references: 23661752
references: J Interferon Cytokine Res. 2011 Jan;31(1):1-4
references: 21226605
references: Genome Biol. 2013 Jan 29;14(1):R9
references: 23360670
references: Annu Rev Genet. 2012;46:677-700
references: 23145935
references: Nature. 2011 Feb 3;470(7332):59-65
references: 21293372
references: Nature. 2011 Jun 29;474(7353):658-61
references: 21720370
references: BMC Syst Biol. 2010 Aug 20;4:117
references: 20727158
references: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15623-8
references: 9861020
references: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3035-40
references: 22315404
references: PLoS Pathog. 2013 Jan;9(1):e1003161
references: 23382686
references: Nat Immunol. 2012 Feb 16;13(3):214-22
references: 22344284
references: Nature. 2011 Apr 28;472(7344):481-5
references: 21478870
references: Science. 2013 Apr 12;340(6129):207-11
references: 23580529
references: Nat Rev Genet. 2010 Feb;11(2):97-108
references: 20051986
references: Nat Rev Genet. 2006 Jul;7(7):552-64
references: 16770338
references: Science. 2010 Dec 10;330(6010):1551-7
references: 21051598
references: Science. 2007 Aug 17;317(5840):944-7
references: 17641165
references: Cell Host Microbe. 2013 May 15;13(5):613-623
references: 23684312
references: Mol Biol Evol. 2013 Jul;30(7):1544-58
references: 23625889
references: PLoS Pathog. 2010 Feb 26;6(2):e1000781
references: 20195503
references: Nat Rev Immunol. 2012 Apr 25;12(5):367-82
references: 22531325
references: Immunity. 2012 Sep 21;37(3):399-411
references: 22999946
references: Annu Rev Med. 2012;63:35-61
references: 22248320
references: Nat Immunol. 2013 Jan;14(1):61-71
references: 23160154
references: PLoS Genet. 2008 Aug 01;4(8):e1000144
references: 18670650
references: Nature. 2011 May 25;474(7353):654-7
references: 21613998
references: Nature. 1977 May 19;267(5608):275-6
references: 865622
references: F1000 Biol Rep. 2009 Sep 28;1:71
references: 20948616
references: PLoS Biol. 2012;10(3):e1001282
references: 22427742
references: Nature. 2012 Nov 1;491(7422):125-8
references: 23000900