title: Evaluation of acute and subacute oral toxicity of the ethanol extract from Antidesma acidum Retz.
abstract: Toxicity tests of 95% ethanol extract of the root of Antidesma acidum were studied in male and female rats. The oral acute toxicity test at 5,000 mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general behavious, mortality and gross appearance of internal organs of rats. Furthermore, the oral sub-acute toxicity test at the dose of 1,000 mg/kg/day displayed no significant changes in body and internal organs' weights, normal hematological and clinical blood chemistry values. Histological examination also showed normal architecture of all internal organs. In conclusion, the ethanol extract of Antidesma acidum did not produce any toxicity in oral acute and suba-cute toxicity studies.
authors: Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand. seewaboon@gmail.com
authors: Seewaboon
authors: S
authors: Sireeratawong
authors: Sopit
authors: S
authors: Thamaree
authors: Kornkanok
authors: K
authors: Ingkaninan
authors: Pritsana
authors: P
authors: Piyabhan
authors: Supaporn
authors: S
authors: Vannasiri
authors: Parirat
authors: P
authors: Khonsung
authors: Tipaya
authors: T
authors: Singhalak
authors: Kanjana
authors: K
authors: Jaijoy
mesh_terms: D000818:Animals; D019665:Euphorbiaceae / Q000009:adverse effects; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute
chemical_list: D010936:Plant Extracts
keywords: Acute toxicity; Antidesma acidum; Subacute toxicity
references: Clin Chem. 1980 Dec;26(13):1877-9
references: 7438435
references: Hum Exp Toxicol. 1996 Aug;15(8):612-6
references: 8863053