title: Diagnostic exercise: hemolysis and sudden death in lambs.
abstract: Within a 24-hour period, 7 out of 200 three- to four-week-old pastured Katahdin lambs died after showing clinical signs of hemoglobinuria, red-tinged feces, weakness, and recumbency. One of the lambs that was examined clinically before natural death also had abdominal pain, trembling, tachycardia, and severe anemia with a packed cell volume of 4%. Pathologic findings included icterus, hemoglobinuric nephrosis, dark red urine, pulmonary edema, hydrothorax, splenomegaly, and acute centrilobular to midzonal hepatocellular degeneration and necrosis with cholestasis. The differential diagnoses and diagnostic workup to achieve the diagnosis are briefly discussed.
authors: 620 West Health Sciences Drive, Davis, CA 95616, USA. Email: fgiannitti@ucdavis.edu.
authors: F
authors: F
authors: Giannitti
authors: M Macias
authors: MM
authors: Rioseco
authors: J P
authors: JP
authors: García
authors: J
authors: J
authors: Beingesser
authors: L W
authors: LW
authors: Woods
authors: B
authors: B
authors: Puschner
authors: F A
authors: FA
authors: Uzal
mesh_terms: D000818:Animals; D003016:Clostridium perfringens; D003645:Death, Sudden / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D004767:Enterotoxemia / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005766:Gastrointestinal Contents; D006456:Hemoglobinuria / Q000662:veterinary; D006461:Hemolysis / Q000502:physiology*; D006652:Histological Techniques / Q000662:veterinary; D006876:Hydrothorax / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D007565:Jaundice / Q000473:pathology / Q000662:veterinary; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D009401:Nephrosis / Q000473:pathology / Q000662:veterinary; D011654:Pulmonary Edema / Q000473:pathology / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology*; D013163:Splenomegaly / Q000473:pathology / Q000662:veterinary
keywords: Clostridium perfringens type D; alpha toxin; hemoglobinuria; icterus; yellow lamb disease