title: Gamma knife radiosurgery for typical trigeminal neuralgia: An institutional review of 108 patients.
abstract: BACKGROUND
  In this study, we present the previously unreported pain relief outcomes of 108 patients treated at Gamma Knife of Spokane for typical trigeminal neuralgia (TN) between 2002 and 2011.
  
  
  METHODS
  Pain relief outcomes were measured using the Barrow Neurological Institute (BNI) pain intensity scale. In addition, the effects gender, age at treatment, pain laterality, previous surgical treatment, repeat Gamma Knife radiosurgery (GKRS), and maximum radiosurgery dose have on patient pain relief outcomes were retrospectively analyzed. Statistical analysis was performed using Andersen 95% confidence intervals, approximate confidence intervals for log hazard ratios, and multivariate Cox proportional hazard models.
  
  
  RESULTS
  All 108 patients included in this study were grouped into BNI class IV or V prior to GKRS. The median clinical follow-up time was determined to be 15 months. Following the first GKRS procedure, 71% of patients were grouped into BNI class I-IIIb (I = 31%; II = 3%; IIIa = 19%; IIIb = 18%) and the median duration of pain relief for those patients was determined to be 11.8 months. New facial numbness was reported in 19% of patients and new facial paresthesias were reported in 7% of patients after the first GKRS procedure. A total of 19 repeat procedures were performed on the 108 patients included in this study. Following the second GKRS procedure, 73% of patients were grouped into BNI class I-IIIb (I = 44%; II = 6%; IIIa = 17%, IIIb = 6%) and the median duration of pain relief for those patients was determined to be 4.9 months. For repeat procedures, new facial numbness was reported in 22% of patients and new facial paresthesias were reported in 6% of patients.
  
  
  CONCLUSIONS
  GKRS is a safe and effective management approach for patients diagnosed with typical TN. However, further studies and supporting research is needed on the effects previous surgical treatment, number of radiosurgery procedures, and maximum radiosurgery dose have on GKRS clinical outcomes.
authors: Department of Neurosurgery, Gamma Knife of Spokane, Spokane, WA USA ; Department of Radiation Oncology, Gamma Knife of Spokane and Cancer Care Northwest, Spokane, Washington, USA.
authors: Ameer L
authors: AL
authors: Elaimy
authors: Andrew F
authors: AF
authors: Lamm
authors: John J
authors: JJ
authors: Demakas
authors: Alexander R
authors: AR
authors: Mackay
authors: Wayne T
authors: WT
authors: Lamoreaux
authors: Robert K
authors: RK
authors: Fairbanks
authors: Robert D
authors: RD
authors: Pfeffer
authors: Barton S
authors: BS
authors: Cooke
authors: Benjamin J
authors: BJ
authors: Peressini
authors: Christopher M
authors: CM
authors: Lee
keywords: Barrow Neurological Institute pain intensity scale; gamma knife radiosurgery; trigeminal neuralgia
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