title: Anti-inflammatory and antioxidant activities of extracts from Musa sapientum peel.
abstract: BACKGROUND
  Many parts of Musa sapientum Linn. (Musaceae) are used in Thai traditional medicine as drugs, food supplements and cosmetics. The banana peel is used as an astringent in foot care, the unripe fruit is used to treat diarrhea and, the ripe fruit is used as tonic.
  
  
  OBJECTIVE
  To evaluate anti-inflammatory and antioxidant activities of banana peel extracts obtained from different extraction methods and to determine their total phenolic content.
  
  
  METHODS
  Four extraction methods were used to extract unripe and ripe peels. Nitric oxide inhibitory and DPPH scavenging assays were used to evaluate anti-inflammatory and antioxidant activities, respectively. Folin-Ciocalteu's reagent was used to determine total phenolic content.
  
  
  RESULTS
  The water extract of fresh ripe peel exhibited the most potent NO inhibitory activity (IC50 = 6.68 +/- 0.34 microg/ml), but apparently exhibited no antioxidant activity. The decoction extract of fresh unripe peel exhibited strong antioxidant activity as well as had the highest total phenolic compound. The antioxidant activity exhibited a correlation with the total phenolic content.
  
  
  CONCLUSIONS
  This study supports the use of Musa sapientum peel in Thai Traditional Medicine for treatment of inflammatory-related diseases.
authors: Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
authors: Pathompong
authors: P
authors: Phuaklee
authors: Srisopa
authors: S
authors: Ruangnoo
authors: Arunporn
authors: A
authors: Itharat
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D051379:Mice; D028521:Musa / Q000737:chemistry; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology*; D018675:Toxicity Tests
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts