title: Depression of local cell-mediated immunity and histological characteristics of disseminated AIDS-related Mycobacterium avium infection after the initiation of antiretroviral therapy.
abstract: OBJECTIVE
  The aim of the present study was to examine the immunohistological characteristics of disseminated Mycobacterium avium infection after the initiation of antiretroviral therapy (ART) for acquired immunodeficiency syndrome (AIDS).
  
  
  METHODS
  We histologically investigated five autopsied AIDS patients with systemic M. avium infection.
  
  
  RESULTS
  The inflammatory cell composition in the affected tissues was assessed using immunohistochemistry. The celiac lymph nodes and intestinal canal were the most commonly involved organs in the AIDS cases. The most common histological feature was unstructured aggregation of histiocytes. Immunohistochemistry revealed depression of CD4(+), CD8(+) and CD57(+) cells in the gut lamina propria and mesenteric lymph nodes.
  
  
  CONCLUSIONS
  These findings suggest that local cell-mediated immunity is depressed in affected tissues and that the primary histological feature is poor organization of granulomas in mycobacterial lesions, despite the administration of adequate ART.
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan. st11029@mdu.ac.jp
authors: Kenji
authors: K
authors: Hibiya
authors: Masao
authors: M
authors: Tateyama
authors: Katsuji
authors: K
authors: Teruya
authors: Makoto
authors: M
authors: Mochizuki
authors: Hideta
authors: H
authors: Nakamura
authors: Daisuke
authors: D
authors: Tasato
authors: Makoto
authors: M
authors: Furugen
authors: Futoshi
authors: F
authors: Higa
authors: Hisako
authors: H
authors: Endo
authors: Yoshimi
authors: Y
authors: Kikuchi
authors: Shinichi
authors: S
authors: Oka
authors: Jiro
authors: J
authors: Fujita
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009162:Mycobacterium avium / Q000276:immunology*; D012189:Retrospective Studies; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents