title: Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis.
abstract: Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB-4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis.
authors: Departamento de Ingeniería Química, Facultad de Ingeniería, Ciencias y Administración, Universidad de La Frontera, Temuco, Chile.
authors: A B
authors: AB
authors: Zepeda
authors: G M
authors: GM
authors: Calaf
authors: C A
authors: CA
authors: Figueroa
authors: J G
authors: JG
authors: Farías
mesh_terms: D000818:Animals; D029798:Blueberry Plants; D004822:Epididymis / Q000473:pathology*; D000860:Hypoxia / Q000517:prevention & control*; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D017392:Thiobarbituric Acid Reactive Substances
keywords: Epididymis; hypobaric hypoxia; infertility; oxidative stress; polyphenols