title: [Prognostic implications of hematopoietic cell transplantation-specific comorbidity index on non-relapse mortality and overall survival after allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To study the prognostic implications of hematopoietic cell transplantation-specific comorbidity index (HCT-CI) on non-relapse mortality (NRM) and overall survival (OS) in patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  
  
  METHODS
  Clinical data of 161 cases received allo-HSCT from July 2003 to November 2010 were analyzed retrospectively. The prognostic significance of HCT-CI, age, sex, conditioning regimens, disease status before transplantation, graft source and the degree of HLA matches for NRM and OS was conducted by COX regression model. The prognostic impact of HCT-CI on NRM and OS was performed in all patients under different disease status before transplantation.
  
  
  RESULTS
  Of the 161 cases with allo-HSCT, 3-year NRM and OS were 26.4% and 61.4% respectively. NRM at 3 years in patients with HCT-CI score 0, 1-2 and ≥3 were 14.9%, 24.5% and 52.7% respectively. And OS at 3 years were 68.9%, 64.6% and 34.7% respectively. There were significant differences between HCT-CI score 0 and ≥3 groups for NRM and OS (P<0.01). High-risk disease status before transplantation (NRM: RR=3.35, P<0.01;OS: RR=3.53, P<0.01) and HCT-CI score≥3 (NRM: RR=6.85, P<0.01;OS: RR=3.77, P<0.01)were independent risk factors by COX regression model. In the subgroup analysis according to disease status, high score of HCT-CI was associated with poor OS (P<0.01) and high NRM (P<0.01) in patients with low-risk, but not in those with high-risk disease status.
  
  
  CONCLUSIONS
  HCT-CI score and disease status before transplantation are independent risk factors for patients received allo-HSCT. HCT-CI score have prognostic implication for NRM and OS in patients with low-risk disease status, but not in high-risk group.
authors: Department of Hematology, Peking University First Hospital, Beijing 100034, China.
authors: Chun-yue
authors: CY
authors: Wang
authors: Han-yun
authors: HY
authors: Ren
authors: Zhi-xiang
authors: ZX
authors: Qiu
authors: Ying
authors: Y
authors: Wang
authors: Xi-nan
authors: XN
authors: Cen
authors: Li-hong
authors: LH
authors: Wang
authors: Mang-ju
authors: MJ
authors: Wang
authors: Wei-lin
authors: WL
authors: Xu
authors: Wen-sheng
authors: WS
authors: Wang
authors: Yuan
authors: Y
authors: Li
authors: Yu-jun
authors: YJ
authors: Dong
authors: Jin-ping
authors: JP
authors: Ou
authors: Ze-yin
authors: ZY
authors: Liang
authors: Wei
authors: W
authors: Liu
authors: Qian
authors: Q
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality*; D006801:Humans; D007938:Leukemia / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D055815:Young Adult