title: Primary small cell carcinoma of the esophagus: patient data metaanalysis and review of the literature.
abstract: We analysed the typical features of primary small cell carcinoma of the esophagus (SCCE) with emphasis on occurrence, behaviour, outcome and treatment options. This metaanalysis was aimed at collecting and analyzing information from international studies about handling this disease. This seems necessary due to the rarity of this disease. Studies were acquired from electronic databases and reference lists. We finally analysed 313 patient cases from the literature with oesophageal SCC. A data extraction was accomplished referring to 13 evaluable features that are described in the "methods", whereof 7 were analyzed with univariate and multivariate tests. Three hundred thirteen cases were analyzed, 109 patients (35%) had limited stage (LS), whereas 167 (54%) had extensive stage (ES). There is no information about the remaining 35 patients concerning the stage. Univariate and multivariate analysis showed only age (<50 years vs. >50 years, HR 1.024; 95% CI 1.000-1.041, P<0.0001) and disease stage (LS vs. ES, HR 4.884; 95% CI 2.572-9.27, P<0.0001) as significant prognostic factors. There also was a statistically significant difference in survival between those patients who received therapy compared to those who only received best supportive care (11.6 months vs. 0.8 months, HR 0.093, CI 95% 0.053-0.16, P<0.001). In this first multivariate analysis for SCCE we show that SCCE is an aggressive type of tumour with a shorter survival rate compared to its counterpart from the lung. It is demonstrated that only disease stage (limited vs. extensive stage), age (<50 years vs. >50 years) and therapy are independent significant predictors of prognosis.
authors: Department of Internal Medicine III, University of Bonn, Germany.
authors: Saineb
authors: S
authors: Al Mansoor
authors: Carsten
authors: C
authors: Ziske
authors: Ingo G H
authors: IG
authors: Schmidt-Wolf
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018288:Carcinoma, Small Cell / Q000401:mortality*; D004938:Esophageal Neoplasms / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017678:Sex Distribution; D016019:Survival Analysis
keywords: esophagus; metaanalysis; oesophagus; small cell carcinoma
references: Ann Thorac Surg. 1973 May;15(5):463-73
references: 4349388
references: Am J Gastroenterol. 1988 Oct;83(10):1176-9
references: 2844080
references: Cancer. 1976 Mar;37(3):1352-8
references: 177167
references: J Pathol Bacteriol. 1952 Oct;64(4):889-91
references: 13000600
references: Ann Thorac Surg. 2011 Feb;91(2):373-8
references: 21256272
references: Cancer. 1978 May;41(5):1890-6
references: 77183
references: Hum Pathol. 1984 May;15(5):460-8
references: 6327495
references: Eur J Surg Oncol. 1990 Apr;16(2):109-15
references: 1691109
references: Int Adv Surg Oncol. 1980;3:73-109
references: 6926744
references: Cancer. 1981 May 15;47(10):2500-2
references: 6268272
references: Histopathology. 1983 Mar;7(2):261-77
references: 6133829
references: Int J Radiat Oncol Biol Phys. 1984 Jan;10(1):147-52
references: 6321409
references: Am J Clin Pathol. 1982 Feb;77(2):123-36
references: 7064914
references: J Urol. 2002 Jul;168(1):192
references: 12050524
references: World J Gastroenterol. 2004 Dec 15;10(24):3680-2
references: 15534932
references: Nihon Shokakibyo Gakkai Zasshi. 2009 Sep;106(9):1334-42
references: 19734705
references: Bone Marrow Transplant. 1999 Oct;24(7):813-4
references: 10516689
references: Ai Zheng. 2006 Sep;25(9):1131-3
references: 16965656
references: J Thorac Cardiovasc Surg. 1994 Dec;108(6):1138-46
references: 7983884
references: AJR Am J Roentgenol. 1981 Sep;137(3):555-7
references: 6269412
references: Chin Med J (Engl). 2007 Mar 5;120(5):355-8
references: 17376302
references: J Clin Gastroenterol. 1990 Aug;12(4):384-8
references: 2168912
references: Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte. 1972 Apr;58(7):225-49
references: 4338754
references: Histopathology. 1977 Jul;1(4):289-99
references: 210102
references: Virchows Arch. 2008 Jan;452(1):103-7
references: 18008084
references: J Clin Pathol. 1976 Dec;29(12):1068-73
references: 188868
references: Gan To Kagaku Ryoho. 2009 Apr;36(4):637-40
references: 19381038
references: Chest. 1995 Jan;107(1):179-81
references: 7813272
references: Acta Oncol. 2007;46(6):846-51
references: 17653910
references: BMC Cancer. 2007 Mar 03;7:38
references: 17335582
references: N Engl J Med. 1992 Nov 12;327(20):1434-41
references: 1328881
references: Cancer. 1994 Jan 1;73(1):1-4
references: 7506114
references: Ann Thorac Surg. 1989 Mar;47(3):477-80
references: 2539065
references: Cancer. 1997 Oct 15;80(8):1366-72
references: 9338459
references: J Med Case Rep. 2008 Jan 22;2:15
references: 18211708