title: A 'tête-à tête' between cancer stem cells and endothelial progenitor cells in tumor angiogenesis.
abstract: Accumulating evidence suggests the involvement of stem cells in tumor angiogenesis. Two major types of stem cells frequently discussed in this regard are bone marrow-derived endothelial progenitor cells (EPCs) and tumor-derived cancer stem cells (CSCs). The present review discusses the possibility of a close association between these two cell types that drives the tumor towards metastasis. An exploration of this plausible relationship between EPCs and CSCs is imperative to completely unveil the mechanisms of tumor angiogenesis and develop CSC- and/or EPC-targeted anti-tumor therapies.
authors: School of Biotechnology, Gautam Buddha University, Greater Noida, 201308, Uttar Pradesh, India, savneetk@gbu.ac.in.
authors: S
authors: S
authors: Kaur
authors: P
authors: P
authors: Bajwa
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D002450:Cell Communication; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000473:pathology; D055153:Stem Cell Niche / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*; D059016:Tumor Microenvironment
references: Circ Res. 2003 Nov 28;93(11):1023-5
references: 14605020
references: Haematologica. 2009 Feb;94(2):258-63
references: 19109217
references: Nat Rev Cancer. 2007 Oct;7(10):733-6
references: 17882276
references: FEBS Lett. 2008 May 14;582(11):1607-12
references: 18423403
references: Brain. 2010 Apr;133(Pt 4):973-82
references: 20375132
references: Nature. 2011 Oct 19;478(7369):399-403
references: 22012397
references: Stem Cells Dev. 2005 Jun;14(3):292-8
references: 15969624
references: Proc Natl Acad Sci U S A. 2008 May 6;105(18):6620-5
references: 18443294
references: Cancer Cell. 2005 Sep;8(3):211-26
references: 16169466
references: Nat Med. 1999 Apr;5(4):434-8
references: 10202935
references: Tissue Eng Part A. 2009 Nov;15(11):3473-86
references: 19435420
references: FASEB J. 2008 Sep;22(9):3234-46
references: 18556461
references: Science. 1997 Feb 14;275(5302):964-7
references: 9020076
references: FEBS Lett. 2009 Aug 6;583(15):2457-63
references: 19596003
references: Cancer Res. 2009 Sep 15;69(18):7243-51
references: 19738068
references: Science. 2008 Jan 11;319(5860):195-8
references: 18187653
references: Blood. 2000 Feb 1;95(3):952-8
references: 10648408
references: Eur J Cancer. 2012 Jun;48(9):1354-62
references: 22370181
references: Oncogene. 2009 May 7;28(18):1960-70
references: 19330021
references: Cell. 2002 May 31;109(5):625-37
references: 12062105
references: PLoS One. 2008 Feb 20;3(2):e1652
references: 18286204
references: Cancer Res. 2010 Dec 1;70(23):9969-78
references: 21098716
references: Cancer Lett. 2007 May 8;249(2):188-97
references: 16997457
references: Curr Neurovasc Res. 2011 Aug 1;8(3):210-9
references: 21675958
references: Nat Med. 1997 Jul;3(7):730-7
references: 9212098
references: Cancer Res. 2008 Aug 1;68(15):6038-42
references: 18676823
references: Cancer Res. 2008 Jun 1;68(11):4331-9
references: 18519693
references: Science. 2008 Jan 11;319(5860):163-4
references: 18187643
references: Int J Biol Sci. 2011;7(6):782-91
references: 21750647
references: J Clin Invest. 2005 Mar;115(3):653-63
references: 15765148
references: FASEB J. 2006 Jul;20(9):1495-7
references: 16754748
references: Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H1-18
references: 16980351
references: Blood. 2001 May 15;97(10):3283-91
references: 11342460
references: Genes Dev. 2007 Jun 15;21(12):1546-58
references: 17575055
references: Cancer Res. 2011 Feb 15;71(4):1474-85
references: 21212411
references: Basic Res Cardiol. 2009 Nov;104(6):739-49
references: 19479297
references: Nature. 2010 Dec 9;468(7325):824-8
references: 21102434
references: Am J Pathol. 1999 Sep;155(3):739-52
references: 10487832
references: Nat Med. 2001 Nov;7(11):1194-201
references: 11689883
references: Biochem Biophys Res Commun. 2007 Aug 31;360(3):553-9
references: 17618600
references: Breast Dis. 2006-2007;26:65-74
references: 17473366
references: EMBO Rep. 2011 May;12(5):470-6
references: 21460795
references: Cancer Res. 2006 Aug 15;66(16):7843-8
references: 16912155
references: J Cell Mol Med. 2004 Jul-Sep;8(3):294-300
references: 15491505
references: Nat Med. 2004 Jan;10(1):64-71
references: 14702636
references: Science. 1999 Apr 2;284(5411):143-7
references: 10102814
references: Nat Rev Cancer. 2010 Feb;10(2):138-46
references: 20094048
references: Stem Cells. 2010 Jun;28(6):1019-29
references: 20506127
references: Cancer Res. 2006 Nov 1;66(21):10247-52
references: 17079441
references: Nature. 1994 Feb 17;367(6464):645-8
references: 7509044
references: Cancer Res. 2011 Jul 15;71(14):4748-57
references: 21616936
references: Circulation. 2001 Feb 6;103(5):634-7
references: 11156872
references: Cancer Res. 2006 Oct 1;66(19):9339-44
references: 16990346
references: PLoS One. 2012;7(6):e39069
references: 22745705
references: Cancer Res. 2005 Jul 1;65(13):5506-11
references: 15994920
references: Nature. 1997 Apr 17;386(6626):671-4
references: 9109485
references: Blood. 2008 May 1;111(9):4551-8
references: 18256324
references: Cancer Res. 2005 Jan 15;65(2):465-72
references: 15695388
references: Circulation. 2003 Mar 4;107(8):1164-9
references: 12615796
references: Nature. 2000 Sep 14;407(6801):249-57
references: 11001068
references: Cancer Res. 2008 Jan 15;68(2):346-51
references: 18199526
references: Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1185-9
references: 12714439
references: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18111-6
references: 16326806
references: Clin Cancer Res. 2009 May 15;15(10):3265-76
references: 19447867