title: Synthesis and anti-histaminic activity of some novel pyrimidines.
abstract: Novel pyrimidines were prepared by the condensation of chalcones of 4'-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1-5 were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.
authors: Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada 520 010, AP, India.
authors: Sk A
authors: SA
authors: Rahaman
authors: Y
authors: Y
authors: Rajendra Pasad
authors: Phani
authors: P
authors: Kumar
authors: Bharath
authors: B
authors: Kumar
keywords: Anti-histaminic activity; Chalcone; Pyrimidine
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