title: The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria.
abstract: Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were sorted into two groups as group A (with CSU) and group B (without CSU). The tissue materials were taken via endoscopy for polymerase chain reaction study to determine virulence factors. After H. pylori eradication therapy, the eradication rate and response of urticaria were evaluated by using C(13)-UBT and a three-point scale (complete remission, partial remission, or no improvement). Results. The results were comparable between patients of groups A and B in terms of H. pylori infection rates and eradication rate. Longitudinal follow-up of 23.5 months showed complete remission of urticaria in 63.6% but no improvement in 36.4% of the patients after H. pylori eradication. H. pylori infected patients with different virulence factors such as cytotoxin-associated gene A, vacuolating cytotoxin gene A signal region and middle region have similar remission rates for CSU. Conclusions. Current study suggests that H. pylori may play a role in the development and disease course of CSU but may be irrelevant to different virulent genotypes.
authors: Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung 833, Taiwan.
authors: Yi-Chun
authors: YC
authors: Chiu
authors: Wei-Chen
authors: WC
authors: Tai
authors: Seng-Kee
authors: SK
authors: Chuah
authors: Ping-I
authors: PI
authors: Hsu
authors: Deng-Chyang
authors: DC
authors: Wu
authors: Keng-Liang
authors: KL
authors: Wu
authors: Chao-Cheng
authors: CC
authors: Huang
authors: Ji-Chen
authors: JC
authors: Ho
authors: Johannes
authors: J
authors: Ring
authors: Wen-Chieh
authors: WC
authors: Chen
references: Allergy Asthma Clin Immunol. 2009 Dec 01;5(1):10
references: 20066173
references: J Gastroenterol. 2004 Sep;39(9):827-30
references: 15565400
references: J Physiol Pharmacol. 2006 Sep;57 Suppl 3:51-65
references: 17033105
references: J Physiol Pharmacol. 2006 Sep;57 Suppl 3:5-14
references: 17033102
references: Eur J Dermatol. 2009 Sep-Oct;19(5):431-44
references: 19527988
references: Intern Med J. 2008 Nov;38(11):852-7
references: 19120535
references: World J Gastroenterol. 2011 Sep 21;17(35):3971-5
references: 22046084
references: Mt Sinai J Med. 2006 May;73(3):622-6
references: 16758102
references: Clin Dermatol. 2010 Sep-Oct;28(5):478-82
references: 20797505
references: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12778-83
references: 10535999
references: Scand J Gastroenterol. 2001 Feb;36(2):128-35
references: 11252403
references: Gut. 2001 Jul;49(1):11-7
references: 11413104
references: Int Arch Allergy Immunol. 1999 May;119(1):60-3
references: 10341322
references: Gastroenterology. 2003 Dec;125(6):1636-44
references: 14724815
references: J Physiol Pharmacol. 2006 Sep;57 Suppl 3:29-50
references: 17033104
references: Am J Gastroenterol. 1994 Aug;89(8 Suppl):S116-28
references: 8048402
references: Int J Dermatol. 2003 Aug;42(8):601-4
references: 12890101
references: J Biol Chem. 1995 Jul 28;270(30):17771-7
references: 7629077
references: Allergol Immunopathol (Madr). 2003 Jul-Aug;31(4):209-14
references: 12890412
references: Med Clin North Am. 2009 Nov;93(6):1211-24
references: 19932327
references: Allergol Immunopathol (Madr). 2002 Sep-Oct;30(5):255-8
references: 12396958
references: Helicobacter. 2001 Mar;6(1):60-5
references: 11328367
references: Int J Dermatol. 2000 Jun;39(6):446-52
references: 10944090
references: J Am Acad Dermatol. 1996 Apr;34(4):685-6
references: 8601663
references: Science. 1998 Jan 16;279(5349):373-7
references: 9430586
references: Ital J Gastroenterol Hepatol. 1999 Apr;31(3):186-91
references: 10379477
references: Allergy. 2009 Oct;64(10):1417-26
references: 19772512
references: J Am Acad Dermatol. 2003 Nov;49(5):861-4
references: 14576665
references: J Bacteriol. 1993 Jun;175(11):3278-88
references: 8501031
references: Gut. 1998 Aug;43(2):182-6
references: 10189841
references: J Clin Microbiol. 2003 Aug;41(8):3737-43
references: 12904384
references: Helicobacter. 2012 Jun;17(3):216-23
references: 22515360
references: Infect Immun. 1998 Dec;66(12):5785-91
references: 9826355
references: Eur J Gastroenterol Hepatol. 1999 Dec;11(12):1371-7
references: 10654797
references: Dig Dis Sci. 1998 Jun;43(6):1226-9
references: 9635612
references: J Clin Microbiol. 1999 Jul;37(7):2274-9
references: 10364597