title: Fructose restrains fibrillogenesis in human serum albumin.
abstract: The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We report the inhibition of HSA fibrillation in the presence of naturally occurring sugars such as glucose, fructose, ribose and sucrose with fructose being the most potent. We have characterized the inhibitory potency of the sugars, using different spectroscopic and microscopic techniques.
authors: Department of Chemistry, Indian Institute of Technology, Kharagpur, Kharagpur 721302, India.
authors: Nitin K
authors: NK
authors: Pandey
authors: Sudeshna
authors: S
authors: Ghosh
authors: Swagata
authors: S
authors: Dasgupta
mesh_terms: D052160:Benzothiazoles; D002942:Circular Dichroism; D005632:Fructose / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006860:Hydrogen Bonding; D046911:Macromolecular Substances / Q000737:chemistry / Q000648:ultrastructure; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism; D013816:Thermodynamics; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism
chemical_list: D052160:Benzothiazoles; D046911:Macromolecular Substances; D012709:Serum Albumin; D013844:Thiazoles; C009462:thioflavin T; D005632:Fructose
keywords: Fibrillation; Human serum albumin; Inhibition; Microscopy; Spectroscopy; Sugars