title: HIV infection is associated with diffusing capacity impairment in women.
abstract: Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DL(CO)) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DL(CO) impairment and airflow obstruction. Providers should be aware that DL(CO) impairment is common in HIV infection, and that either DL(CO) impairment or airflow obstruction may cause respiratory symptoms in this population.
authors: *Department of Medicine, University of Pittsburgh, Pittsburgh, PA; †Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; ‡Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA; Departments of §Medicine; ‖Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA; and ¶Department of Immunology, University of Pittsburgh, Pittsburgh, PA.
authors: Meghan E
authors: ME
authors: Fitzpatrick
authors: Matthew R
authors: MR
authors: Gingo
authors: Cathy
authors: C
authors: Kessinger
authors: Lorrie
authors: L
authors: Lucht
authors: Eric
authors: E
authors: Kleerup
authors: Ruth M
authors: RM
authors: Greenblatt
authors: David
authors: D
authors: Claman
authors: Claudia
authors: C
authors: Ponath
authors: Serena
authors: S
authors: Fong
authors: Laurence
authors: L
authors: Huang
authors: Alison
authors: A
authors: Morris
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D011653:Pulmonary Diffusing Capacity; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology* / Q000821:virology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry; D014481:United States / Q000453:epidemiology
references: Thorax. 1996 Mar;51(3):312-4
references: 8779138
references: Ann Intern Med. 2000 Mar 7;132(5):369-72
references: 10691587
references: Respir Med. 2011 Nov;105(11):1655-61
references: 21703841
references: J Infect Dis. 2010 Mar 15;201(6):823-34
references: 20151840
references: Chest. 1991 Nov;100(5):1268-71
references: 1935280
references: Eur Respir J. 2005 Nov;26(5):948-68
references: 16264058
references: PLoS One. 2009 Jul 21;4(7):e6328
references: 19621086
references: Comput Programs Biomed. 1978 Jun;8(2):121-34
references: 668307
references: J Med Virol. 2002 Jan;66(1):34-9
references: 11748656
references: Epidemiol Infect. 2010 Feb;138(2):167-73
references: 19563696
references: Am J Respir Crit Care Med. 1999 Jan;159(1):179-87
references: 9872837
references: Circ Heart Fail. 2010 Jan;3(1):132-9
references: 19933410
references: AIDS. 2012 Mar 27;26(6):731-40
references: 22210636
references: Am J Respir Crit Care Med. 2008 Jan 1;177(1):108-13
references: 17932378
references: Respiration. 2006;73(3):318-23
references: 16179822
references: MMWR Morb Mortal Wkly Rep. 2011 Jun 3;60(21):689-93
references: 21637182
references: AIDS. 2012 Sep 24;26(15):1879-84
references: 22824629
references: Clin Diagn Lab Immunol. 2005 Sep;12(9):1013-9
references: 16148165
references: Clin Physiol Funct Imaging. 2012 Jul;32(4):288-95
references: 22681606
references: BMC Pulm Med. 2010 May 11;10:27
references: 20459792
references: Clin Infect Dis. 2002 Mar 15;34(6):831-7
references: 11833007
references: Chest. 2006 Nov;130(5):1326-33
references: 17099007
references: Am J Respir Crit Care Med. 1996 Feb;153(2):656-64
references: 8564114
references: Respir Res. 2006 Mar 29;7:52
references: 16571126
references: Am J Respir Crit Care Med. 2010 Sep 15;182(6):790-6
references: 20522793
references: AIDS Res Ther. 2010 Mar 19;7:6
references: 20298614
references: Thorax. 1997 Jan;52(1):33-7
references: 9039237
references: Eur Respir J. 2005 Oct;26(4):720-35
references: 16204605
references: Am J Public Health. 2006 Jun;96(6):1060-5
references: 16670229
references: Qual Life Res. 2010 Nov;19(9):1295-302
references: 20617387
references: Epidemiology. 1998 Mar;9(2):117-25
references: 9504278
references: Clin Infect Dis. 2011 Feb 1;52(3):378-86
references: 21217185
references: Eur Respir J. 2005 Aug;26(2):319-38
references: 16055882
references: Am J Med. 2004 Jun 1;116(11):749-52
references: 15144911
references: Am J Respir Crit Care Med. 2011 Feb 1;183(3):388-95
references: 20851926
references: Chest. 2003 Feb;123(2):600-3
references: 12576385
references: Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120
references: 742764
references: Am J Respir Crit Care Med. 1995 Aug;152(2):738-45
references: 7633736