title: Functionalization of gold nanoparticles as antidiabetic nanomaterial.
abstract: In the present investigation, functionalization of gold nanoparticles synthesized using propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl) (PAT) an active biocomponent isolated from Cassia auriculata is studied in detail. On reaction of PAT with aqueous HAuCl4, rapid formation of stable gold nanoparticles was achieved. Formation of gold nanoparticles was confirmed by UV-vis spectroscopy, XRD, GC-MS,FTIR, TEM and SEM with EDAX. Gold nanoparticles mostly were monodisperse, spherical in shape and ranged in size 12-41 nm. Gold nanoparticles synthesised using PAT was administered to alloxan (150 mg/kg body weight) induced diabetic male albino rats at different doses (0.25, 0.5, 0.75 and 1.0mg/kg body weight) for 28 days. Plasma glucose level, cholesterol and triglyceride were significantly (p<0.001) reduced in experimental animals treated with gold nanoparticles at dosage of 0.5mg/kg body weight and plasma insulin increased significantly. The newly genre green gold nanoparticles exhibit remarkable protein tyrosine phosphatase 1B inhibitory activity.
authors: Department of Biochemistry, Institute of Veterinary Preventive Medicine, Ranipet 632402, India.
authors: M
authors: M
authors: Venkatachalam
authors: K
authors: K
authors: Govindaraju
authors: A
authors: A
authors: Mohamed Sadiq
authors: S
authors: S
authors: Tamilselvan
authors: V
authors: V
authors: Ganesh Kumar
authors: G
authors: G
authors: Singaravelu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002366:Cassia / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D017612:Gold Compounds / Q000737:chemistry; D055772:Green Chemistry Technology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D051381:Rats
chemical_list: D001786:Blood Glucose; D002712:Chlorides; D017612:Gold Compounds; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D006046:Gold; C024568:gold tetrachloride, acid; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Antidiabetic activity; Gold nanoparticles; Green synthesis; Propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl)