title: Synergy of non-antibiotic drugs and pyrimidinethiol on gold nanoparticles against superbugs.
abstract: Co-presenting non-antibiotic drugs and pyrimidinethiol on gold nanoparticles (NPs) can generate broad-spectrum antibacterial and bactericidal activities against superbugs. Dimethylbiguanide (metformin), an anti-hyperglycemic drug, shows the best enhanced activity via increasing the ability to compromise bacterial cell walls. Synergistic effects are also reflected in the eradicating biofilm cells. Our findings suggest a large chemical space to develop new antibacterial materials to treat superbugs.
authors: Department of Chemistry, Tsinghua University, National Center for NanoScience and Technology, Beijing 100084, China.
authors: Yuyun
authors: Y
authors: Zhao
authors: Zeliang
authors: Z
authors: Chen
authors: Yanfen
authors: Y
authors: Chen
authors: Jie
authors: J
authors: Xu
authors: Jinghong
authors: J
authors: Li
authors: Xingyu
authors: X
authors: Jiang
mesh_terms: D000900:Anti-Bacterial Agents; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004357:Drug Synergism; D006046:Gold / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008687:Metformin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C521859:2-pyrimidinethiol; D000900:Anti-Bacterial Agents; D007004:Hypoglycemic Agents; D011743:Pyrimidines; D013438:Sulfhydryl Compounds; D006046:Gold; D008687:Metformin