title: Pharmacological treatments in ARDS; a state-of-the-art update.
abstract: Despite its high incidence and devastating outcomes, acute respiratory distress syndrome (ARDS) has no specific treatment, with effective therapy currently limited to minimizing potentially harmful ventilation and avoiding a positive fluid balance. Many pharmacological therapies have been investigated with limited success to date. In this review article we provide a state-of-the-art update on recent and ongoing trials, as well as reviewing promising future pharmacological therapies in ARDS.
authors: Centre for Infection and Immunity, Health Sciences Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. d.f.mcauley@qub.ac.uk.
authors: Andrew James
authors: AJ
authors: Boyle
authors: Rob
authors: R
authors: Mac Sweeney
authors: Daniel Francis
authors: DF
authors: McAuley
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
references: Am J Respir Crit Care Med. 2011 Sep 1;184(5):561-8
references: 21562125
references: BMJ. 2008 May 3;336(7651):1006-9
references: 18434379
references: Lancet. 2012 Jan 21;379(9812):229-35
references: 22166903
references: Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L924-40
references: 11943656
references: BMJ. 2007 Apr 14;334(7597):779
references: 17383982
references: Trials. 2013 Apr 17;14:100
references: 23782429
references: N Engl J Med. 2005 Oct 20;353(16):1685-93
references: 16236739
references: N Engl J Med. 2006 Apr 20;354(16):1671-84
references: 16625008
references: Crit Care Med. 2004 Aug;32(8):1695-702
references: 15286546
references: N Engl J Med. 2003 Feb 20;348(8):683-93
references: 12594312
references: Eur J Immunol. 2007 Dec;37(12):3334-8
references: 18034430
references: Am J Respir Crit Care Med. 2011 Mar 1;183(5):620-6
references: 20870757
references: Crit Care Med. 2010 Oct;38(10 Suppl):S569-73
references: 21164399
references: Crit Care. 2010;14(6):R198
references: 21047406
references: N Engl J Med. 2000 May 4;342(18):1301-8
references: 10793162
references: Lancet. 1967 Aug 12;2(7511):319-23
references: 4143721
references: Clin Ther. 2008 May;30(5):787-99
references: 18555927
references: Crit Care Med. 2011 Nov;39(11):2393-400
references: 21725238
references: J Surg Res. 2008 Mar;145(1):25-32
references: 17688881
references: Trials. 2012 Sep 17;13:170
references: 22985805
references: Am J Respir Crit Care Med. 2009 Jun 15;179(12):1107-14
references: 19324974
references: Cochrane Database Syst Rev. 2010 Aug 04;(8):CD007733
references: 20687093
references: Intern Med. 2010;49(22):2423-32
references: 21088343
references: Eur Respir J. 2005 Jul;26(1):101-5
references: 15994395
references: Nature. 2005 Jul 7;436(7047):112-6
references: 16001071
references: J Immunol. 2007 Aug 1;179(3):1855-63
references: 17641052
references: Curr Med Chem. 2008;15(19):1911-24
references: 18691048
references: Chest. 2007 Apr;131(4):954-63
references: 17426195
references: Am J Respir Crit Care Med. 2013 Apr 1;187(7):751-60
references: 23292883
references: Steroids. 2011 Nov;76(12):1305-9
references: 21745487
references: N Engl J Med. 2010 Sep 16;363(12):1107-16
references: 20843245
references: Am Rev Respir Dis. 1988 Jul;138(1):62-8
references: 3202402
references: Am J Respir Crit Care Med. 2006 Feb 1;173(3):281-7
references: 16254268
references: N Engl J Med. 1984 Nov 1;311(18):1137-43
references: 6384785
references: Chest. 2011 Feb;139(2):289-295
references: 20688925
references: Crit Care. 2010;14(5):R180
references: 20937093
references: Trials. 2013 Feb 18;14:51
references: 23419093
references: Nat Med. 2012 Apr 15;18(5):759-65
references: 22504485
references: Am J Respir Crit Care Med. 2011 Apr 15;183(8):1055-61
references: 21148720
references: Arch Surg. 1985 May;120(5):536-40
references: 3885915