title: A degrading view of regulatory T cells.
abstract: Studies by van Loosdregt et al. and Chen et al. in this issue of Immunity provide evidence for previously unrecognized players that regulate FOXP3 degradation. These are interesting developments that point to unappreciated mechanisms by which inflammatory signals can impact expression of FOXP3 and possibly the stability of Treg cell phenotypes.
authors: National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA.
authors: Arian
authors: A
authors: Laurence
authors: Yasmine
authors: Y
authors: Belkaid
authors: John J
authors: JJ
authors: O'Shea
mesh_terms: D000818:Animals; D003092:Colitis / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*; D000076084:Ubiquitin-Specific Peptidase 7
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7