title: Heat shock protein27 expression and cell differentiation in ameloblastomas.
abstract: The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.
authors: Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan.
authors: Muneteru
authors: M
authors: Fujita
authors: Keisuke
authors: K
authors: Nakano
authors: Ariyoshi
authors: A
authors: Funato
authors: Yoshihiko
authors: Y
authors: Sugita
authors: Toshikatsu
authors: T
authors: Kubo
authors: Hatsuhiko
authors: H
authors: Maeda
authors: Norimasa
authors: N
authors: Okafuji
authors: Hiromasa
authors: H
authors: Hasegawa
authors: Toshiyuki
authors: T
authors: Kawakami
mesh_terms: D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D055815:Young Adult
chemical_list: D055551:HSP27 Heat-Shock Proteins
keywords: CK; HSP; ameloblatoma; cell differentiation.; immunohistochemistry
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