title: Graphene oxide-based magnetic fluorescent hybrids for drug delivery and cellular imaging.
abstract: A graphene oxide (GO)-based multifunctional hybrid has been developed for loading and delivery of anticancer drugs. The GO was functionalized by magnetic/fluorescent SiO2 microsphere via an amidation process. Doxorubicin (DOX) was chosen as a model drug to be loaded onto the GO via π-π stacking and hydrophobic interaction. The loading capacities of DOX to the GO-based magnetic fluorescent hybrids were investigated. The release profiles of DOX from the hybrids were depicted. The fluorescence images of the GO-based magnetic fluorescent hybrids indicated that the hybrids would be an effective drug carrier and a potential optical imaging tool. The application of the developed GO-based magnetic fluorescent hybrids for HepG2 cells demonstrated an excellent therapeutic effect of the DOX loaded hybrids to the target tumor.
authors: State Key Laboratory on Integrated Optoelectronics , College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
authors: Yuan
authors: Y
authors: Gao
authors: Xin
authors: X
authors: Zou
authors: Julia Xiaojun
authors: JX
authors: Zhao
authors: Yan
authors: Y
authors: Li
authors: Xingguang
authors: X
authors: Su
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D060328:Magnetic Phenomena; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D061848:Optical Imaging / Q000379:methods; D013050:Spectrometry, Fluorescence
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D053769:Nanocapsules; D006108:Graphite; D004317:Doxorubicin
keywords: Cellular imaging; Drug delivery; Fluorescent; Graphene oxide; Magnetic; Multi-functional materials