title: The controversial role of microglia in malignant gliomas.
abstract: Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.
authors: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-1402, USA.
authors: Jun
authors: J
authors: Wei
authors: Konrad
authors: K
authors: Gabrusiewicz
authors: Amy
authors: A
authors: Heimberger
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D002450:Cell Communication; D005910:Glioma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D017628:Microglia / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*
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