title: Clonal evolution in hematological malignancies and therapeutic implications.
abstract: The ability of cancer to evolve and adapt is a principal challenge to therapy in general and to the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of multiple, genetically heterogeneous subpopulations within the cancer cell population. Increasing evidence has supported the idea that these subpopulations are selected in a Darwinian fashion, by which the genetic landscape of the tumor is continuously reshaped. Massively parallel sequencing has enabled a recent surge in our ability to study this process, adding to previous efforts using cytogenetic methods and targeted sequencing. Altogether, these studies reveal the complex evolutionary trajectories occurring across individual hematological malignancies. They also suggest that while clonal evolution may contribute to resistance to therapy, treatment may also hasten the evolutionary process. New insights into this process challenge us to understand the impact of treatment on clonal evolution and inspire the development of novel prognostic and therapeutic strategies.
authors: 1] Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA [2] Broad Institute, Cambridge, MA, USA [3] Department of Hematology, Yale Cancer Center, New Haven, CT, USA [4] Université Paris Diderot, Paris, France.
authors: D A
authors: DA
authors: Landau
authors: Broad Institute, Cambridge, MA, USA.
authors: S L
authors: SL
authors: Carter
authors: 1] Broad Institute, Cambridge, MA, USA [2] Massachusetts General Hospital Cancer Center and Department of Pathology, Boston, MA, USA.
authors: G
authors: G
authors: Getz
authors: 1] Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA [3] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: C J
authors: CJ
authors: Wu
mesh_terms: D019143:Evolution, Molecular; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans
references: Nat Rev Cancer. 2006 Dec;6(12):924-35
references: 17109012
references: J Exp Med. 2011 Apr 11;208(4):653-61
references: 21464223
references: N Engl J Med. 2001 Apr 5;344(14):1031-7
references: 11287972
references: Blood. 2010 Nov 11;116(19):3923-32
references: 20693430
references: Blood. 2011 Dec 15;118(25):6521-8
references: 21931113
references: Nature. 2013 Jul 11;499(7457):214-218
references: 23770567
references: Blood. 2007 Feb 1;109(3):944-50
references: 17032921
references: Nat Genet. 2013 Mar;45(3):229-31
references: 23435090
references: Oncogene. 2009 Apr 16;28(15):1807-11
references: 19287454
references: Br J Cancer. 2011 Feb 1;104(3):392-8
references: 21139585
references: Nature. 2008 Dec 4;456(7222):593-8
references: 19052619
references: PLoS Genet. 2013;9(1):e1003137
references: 23326238
references: Cancer Cell. 2004 Dec;6(6):587-96
references: 15607963
references: Cancer Cell. 2011 Dec 13;20(6):810-7
references: 22137795
references: Science. 1990 Mar 2;247(4946):1079-82
references: 2408149
references: Cancer Res. 1987 May 15;47(10):2604-8
references: 3567893
references: Cancer Res. 2009 Jun 1;69(11):4894-903
references: 19487300
references: N Engl J Med. 2010 Aug 26;363(9):809-19
references: 20818844
references: Nat Rev Cancer. 2004 Mar;4(3):177-83
references: 14993899
references: Cell. 2011 Mar 4;144(5):646-74
references: 21376230
references: N Engl J Med. 2013 Jul 11;369(2):111-21
references: 23841729
references: N Engl J Med. 2011 Dec 29;365(26):2497-506
references: 22150006
references: J Clin Oncol. 2008 Sep 10;26(26):4268-75
references: 18626007
references: Genes Dev. 2010 Aug 15;24(16):1731-45
references: 20713517
references: Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4828-33
references: 19261858
references: Cell. 1997 Mar 7;88(5):593-602
references: 9054499
references: Nat Biotechnol. 2012 May;30(5):413-21
references: 22544022
references: Cancer Res. 2012 Oct 1;72(19):4875-82
references: 23002210
references: Cell. 2011 Mar 18;144(6):910-25
references: 21414483
references: Science. 2013 Feb 1;339(6119):543-8
references: 23239622
references: Cancer Cell. 2011 Dec 13;20(6):695-7
references: 22172718
references: Cell. 2009 Aug 21;138(4):645-659
references: 19682730
references: Science. 2008 Nov 28;322(5906):1377-80
references: 19039135
references: Nat Rev Cancer. 2011 Jun;11(6):450-7
references: 21593786
references: PLoS Genet. 2012;8(2):e1002533
references: 22359517
references: Cell. 2012 Jul 20;150(2):264-78
references: 22817890
references: N Engl J Med. 2000 Dec 28;343(26):1910-6
references: 11136261
references: Blood. 1992 Dec 15;80(12):2983-90
references: 1467514
references: Nat Genet. 2006 Apr;38(4):468-73
references: 16565718
references: Nature. 2010 Jan 14;463(7278):191-6
references: 20016485
references: Cancer Cell. 2002 Aug;2(2):117-25
references: 12204532
references: Blood. 2012 Aug 2;120(5):1060-6
references: 22529291
references: Nature. 2011 Jan 20;469(7330):356-61
references: 21160474
references: Blood. 2012 Nov 15;120(20):4117-8
references: 23160186
references: N Engl J Med. 2009 Jul 9;361(2):123-34
references: 19553641
references: Nat Med. 2009 Sep;15(9):1010-2
references: 19734877
references: N Engl J Med. 2012 Mar 8;366(10):883-892
references: 22397650
references: Science. 2008 Sep 26;321(5897):1807-12
references: 18772396
references: Nat Rev Cancer. 2012 Sep;12(9):587-98
references: 22918414
references: Proc Natl Acad Sci U S A. 2001 May 8;98(10):5393-8
references: 11344284
references: J Clin Oncol. 2009 Sep 20;27(27):4585-90
references: 19687334
references: J Clin Invest. 2010 Feb;120(2):401-3
references: 20101092
references: N Engl J Med. 2012 Mar 22;366(12):1079-89
references: 22417203
references: Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13081-6
references: 18723673
references: Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22745-50
references: 21149740
references: Biol Blood Marrow Transplant. 2011 Oct;17(10):1450-1459.e1
references: 21781950
references: Int J Oncol. 2008 Apr;32(4):729-37
references: 18360700
references: Cancer Res. 2006 Aug 15;66(16):7854-8
references: 16912157
references: Nat Med. 2011 Mar;17(3):313-9
references: 21386835
references: Cancer Lett. 2006 Jan 28;232(1):13-26
references: 16236432
references: Biol Blood Marrow Transplant. 2010 Jun;16(6):709-28
references: 20227509
references: Cell. 1990 Jun 1;61(5):759-67
references: 2188735
references: Blood. 2013 Feb 28;121(9):1604-11
references: 23297126
references: Nature. 1992 Oct 8;359(6395):552-4
references: 1406975
references: N Engl J Med. 2004 Aug 12;351(7):657-67
references: 15306667
references: J Natl Cancer Inst. 1999 May 19;91(10):861-8
references: 10340906
references: N Engl J Med. 2013 May 30;368(22):2059-74
references: 23634996
references: Nature. 2010 Feb 18;463(7283):899-905
references: 20164920
references: N Engl J Med. 2012 Mar 22;366(12):1090-8
references: 22417201
references: Cell. 2010 Jan 8;140(1):62-73
references: 20074520
references: Cell. 2012 Mar 2;148(5):873-85
references: 22385957
references: Blood. 2002 Aug 1;100(3):1014-8
references: 12130516
references: Cancer Res. 1978 Sep;38(9):2651-60
references: 354778
references: Cell. 2009 Sep 18;138(6):1083-95
references: 19766563
references: Biol Blood Marrow Transplant. 2010 Dec;16(12):1649-57
references: 20558312
references: Science. 1976 Oct 1;194(4260):23-8
references: 959840
references: N Engl J Med. 2001 Apr 5;344(14):1038-42
references: 11287973
references: Science. 2004 Feb 6;303(5659):793-9
references: 14764867
references: Nature. 2009 May 21;459(7245):428-32
references: 19363473
references: Blood. 2012 Aug 2;120(5):1067-76
references: 22498740
references: Cancer Res. 2004 May 15;64(10):3414-27
references: 15150093
references: Clin Cancer Res. 2009 Jul 15;15(14):4622-9
references: 19584161
references: Haematologica. 2011 Aug;96(8):1161-9
references: 21546498
references: Nature. 2011 Apr 7;472(7341):90-4
references: 21399628
references: Leukemia. 2013 Dec;27(12):2376-9
references: 23612016
references: Nature. 2008 Feb 28;451(7182):1111-5
references: 18264088
references: Blood. 2012 Nov 15;120(20):4191-6
references: 22915640
references: Cell. 2012 Mar 2;148(5):886-95
references: 22385958
references: Semin Cancer Biol. 2010 Apr;20(2):65-70
references: 20359535
references: Cancer Res. 2012 Feb 1;72(3):779-89
references: 22180495
references: Blood. 2013 Feb 21;121(8):1403-12
references: 23243274
references: Blood. 2009 Oct 15;114(16):3367-75
references: 19636060
references: Nature. 2013 Jun 13;498(7453):236-40
references: 23685454
references: Transplantation. 2012 Apr 15;93(7):744-9
references: 22314337
references: Proc Natl Acad Sci U S A. 1982 Sep;79(18):5547-51
references: 6957880
references: Nature. 2012 Apr 04;486(7403):395-9
references: 22495314
references: Cancer Genet. 2011 Dec;204(12):654-65
references: 22285017
references: Cell. 2008 Dec 12;135(6):1009-12
references: 19070571
references: Nat Rev Cancer. 2012 Apr 12;12(5):335-48
references: 22495321
references: Nat Rev Genet. 2013 Mar;14(3):204-20
references: 23400093
references: Nat Rev Cancer. 2012 Jun 14;12(7):487-93
references: 22695393
references: Br J Haematol. 2006 Apr;133(1):50-8
references: 16512828
references: N Engl J Med. 2008 Jul 24;359(4):366-77
references: 18596266
references: N Engl J Med. 2004 May 20;350(21):2129-39
references: 15118073
references: Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18545-50
references: 20876136
references: Nat Rev Genet. 2010 Oct;11(10):685-96
references: 20847746
references: Blood. 2012 Nov 22;120(22):4407-17
references: 22932801
references: Leukemia. 2013 Apr;27(5):1188-91
references: 23147253
references: Nat Rev Genet. 2006 Jan;7(1):34-44
references: 16369570
references: Leuk Res. 2004 May;28 Suppl 1:S47-52
references: 15036941
references: Cell. 2013 Feb 14;152(4):714-26
references: 23415222
references: Cell. 2012 May 25;149(5):994-1007
references: 22608083
references: Haematologica. 2007 Sep;92(9):1242-5
references: 17666364
references: Blood. 2009 Nov 26;114(23):4832-42
references: 19789386
references: Nat Med. 2013 Mar;19(3):368-71
references: 23377281
references: Blood. 2002 Sep 15;100(6):1965-71
references: 12200353
references: Nature. 2012 Jan 18;481(7381):306-13
references: 22258609
references: Nature. 2012 Jan 11;481(7382):506-10
references: 22237025
references: Leukemia. 2013 Apr;27(5):1155-64
references: 23295736