title: Additional cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes violatinctus and biogenetic considerations.
abstract: The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. A general hypothetical biogenetic pathway is then proposed for pyridoacridine alkaloids that contain a fused pyrrole ring. Comparison of the biological properties of the isolated alkaloids is also discussed.
authors: Laboratoire de Chimie des Biomolécules et de l'Environnement, EA4215, Université de Perpignan via Domitia , 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France.
authors: Nataly
authors: N
authors: Bontemps
authors: Florence
authors: F
authors: Gattacceca
authors: Christophe
authors: C
authors: Long
authors: Olivier P
authors: OP
authors: Thomas
authors: Bernard
authors: B
authors: Banaigs
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D008542:Melanesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010618:Phenanthrolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000166:Acridines; D000470:Alkaloids; D000970:Antineoplastic Agents; D010618:Phenanthrolines; C475900:pyridoacridine