title: Liver transplantation for acute liver failure caused by macrophage activation syndrome.
abstract: Macrophage activation syndrome (MAS) is a rare, potentially fatal condition, which most frequently complicates rheumatological conditions and is often associated with liver dysfunction. In this case report of a patient with MAS, acute liver failure developed despite conventional immunosuppressive therapy. Liver transplantation resulted in rapid recovery and the patient has remained well for six years. A recent diagnosis of Adult Onset Still's Disease (AOSD) provides additional supporting evidence that the initial presentation was caused by MAS. While transplantation in the context of systemic disease remains controversial, this first reported case of successful adult liver transplantation for acute liver failure caused by MAS raises an interesting clinical dilemma.
authors: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; Liver Unit, Freeman Hospital, Newcastle upon Tyne, UK.
authors: James
authors: J
authors: Orr
authors: Yvonne
authors: Y
authors: Bury
authors: Mark
authors: M
authors: Hudson
authors: Steven
authors: S
authors: Masson
mesh_terms: D000328:Adult; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology* / Q000601:surgery; D016031:Liver Transplantation; D055501:Macrophage Activation Syndrome / Q000150:complications*; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000150:complications
keywords: acute liver failure; adult onset still's disease; liver transplantation; macrophage activation syndrome