title: [Influence of obesity on urological malignancies].
abstract: BACKGROUND
  Overweight presents a growing problem in our society; therefore, there is an increasing interest to understand the influence of obesity on urological forms of cancer.
  
  
  OBJECTIVE
  In prostate cancer the development of a more aggressive phenotype seems to correlate with obesity. In renal cell cancer (RCC) obesity is both, a risk factor for occurrence -and is also associated with an improved tumour-specific survival in patients with organ-confined disease following kidney surgery as well as overall survival of patients with advanced disease receiving VEGF(R)-targeted treatment. In contrast, even though an association between body mass index (BMI) and bladder cancer has been described the role of obesity in bladder cancer remains largely unclear as published data are contradictory.
  
  
  RESULTS
  An update on currently available data focusing on the relationship between obesity and genitourinary malignancies is given in this review; however, basic research which is necessary to define the biological and metabolic effects associated with obesity and which might affect the development and progression of urological cancers, is indicated.
authors: Klinik für Urologie und urologische Onkologie, Medizinische Hochschule Hannover, Carl-Neubergstraße 1, 30625, Hannover, Deutschland.
authors: H
authors: H
authors: Eggers
authors: M A
authors: MA
authors: Kuczyk
authors: A J
authors: AJ
authors: Schrader
authors: S
authors: S
authors: Steffens
mesh_terms: D015897:Comorbidity; D019317:Evidence-Based Medicine; D006801:Humans; D009765:Obesity / Q000175:diagnosis* / Q000401:mortality*; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D014571:Urologic Neoplasms / Q000175:diagnosis* / Q000401:mortality*
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