title: Molecular interactions in the development of brain metastases.
abstract: Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.
authors: Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. nlmartinez@gmail.com
authors: Nina
authors: N
authors: Martinez
authors: Adrienne
authors: A
authors: Boire
authors: Lisa M
authors: LM
authors: Deangelis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control / Q000556:secondary*; D006801:Humans; D009361:Neoplasm Invasiveness; D009928:Organ Specificity; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
references: Cancer Metastasis Rev. 2001;20(1-2):13-25
references: 11831641
references: J Clin Oncol. 2006 Dec 20;24(36):5658-63
references: 17102066
references: J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
references: 3346912
references: Nat Rev Clin Oncol. 2011 Jun;8(6):333-42
references: 21522123
references: Expert Rev Anticancer Ther. 2012 Nov;12(11):1429-35
references: 23249107
references: J Clin Oncol. 2004 Jul 15;22(14):2865-72
references: 15254054
references: Mayo Clin Proc. 2012 Oct;87(10):976-81
references: 23036672
references: Clin Cancer Res. 2011 Sep 15;17(18):5850-7
references: 21673068
references: Nat Med. 2010 Jan;16(1):116-22
references: 20023634
references: N Engl J Med. 1990 Feb 22;322(8):494-500
references: 2405271
references: Am J Pathol. 2010 Jun;176(6):2958-71
references: 20382702
references: Neoplasia. 2011 Mar;13(3):286-98
references: 21390191
references: Cancer Res. 2007 May 1;67(9):4190-8
references: 17483330
references: Int J Cancer. 2011 Jun 1;128(11):2527-35
references: 21365651
references: Clin Cancer Res. 2009 Nov 15;15(22):7020-8
references: 19887484
references: J Natl Compr Canc Netw. 2008 May;6(5):505-13; quiz 514
references: 18492462
references: Nat Rev Cancer. 2010 Dec;10(12):871-7
references: 21048784
references: JAMA. 2006 Jun 7;295(21):2483-91
references: 16757720
references: Recent Results Cancer Res. 2012;195:25-39
references: 22527492
references: Lancet. 2004 May 22;363(9422):1665-72
references: 15158627
references: J Neurooncol. 2010 Jan;96(1):71-83
references: 19960229
references: Nature. 2010 Nov 25;468(7323):557-61
references: 20944627
references: Ann Oncol. 2003 Jul;14(7):1072-7
references: 12853349
references: Mol Cancer Res. 2004 Jun;2(6):327-38
references: 15235108
references: Neuro Oncol. 2011 Dec;13(12):1364-9
references: 21865399
references: J Neurooncol. 2011 Sep;104(3):689-96
references: 21359851
references: Ann Oncol. 2004 Jul;15(7):1042-7
references: 15205197
references: Cancer Res. 2009 Feb 1;69(3):828-35
references: 19141644
references: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6674-9
references: 22451897
references: Cancer Res. 2000 Sep 1;60(17):4767-70
references: 10987284
references: Cell Cycle. 2006 Aug;5(16):1744-50
references: 16861927
references: Clin Exp Metastasis. 2011 Jan;28(1):13-25
references: 20953899
references: Trends Neurosci. 2001 Dec;24(12):719-25
references: 11718877
references: Eur Respir J. 2009 Feb;33(2):436-40
references: 19181917
references: Cell. 2009 Dec 24;139(7):1315-26
references: 20064377
references: Neuro Oncol. 2004 Apr;6(2):154-65
references: 15134630
references: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3119-27
references: 23071298
references: Clin Cancer Res. 2009 Feb 15;15(4):1452-9
references: 19228746
references: Cancer Treat Rev. 2003 Dec;29(6):533-40
references: 14585263
references: Future Oncol. 2009 Sep;5(7):1083-98
references: 19792975
references: Cancer Cell. 2008 Jan;13(1):58-68
references: 18167340
references: Lab Invest. 1997 Oct;77(4):357-68
references: 9354770
references: Nat Rev Neurosci. 2006 Jan;7(1):41-53
references: 16371949
references: Magn Reson Med. 2006 Nov;56(5):1001-10
references: 17029229
references: APMIS. 2008 Jul-Aug;116(7-8):586-601
references: 18834404
references: Clin Breast Cancer. 2003 Jun;4(2):114-9
references: 12864939
references: Oncologist. 2007 Jul;12(7):884-98
references: 17673619
references: Adv Cancer Res. 2009;102:67-101
references: 19595307
references: PLoS One. 2009 Jun 10;4(6):e5857
references: 19516901
references: Neurosurg Clin N Am. 2011 Jan;22(1):1-6, v
references: 21109143
references: Int J Oncol. 2008 Oct;33(4):705-12
references: 18813783
references: Nat Rev Cancer. 2009 Apr;9(4):274-84
references: 19308067
references: Cell. 2012 Jun 8;149(6):1192-205
references: 22682243
references: Breast Cancer. 2014 Nov;21(6):677-83
references: 23335064
references: Nat Rev Genet. 2007 May;8(5):341-52
references: 17440531
references: Curr Opin Oncol. 2012 Nov;24(6):679-86
references: 22820413
references: Neuro Oncol. 2012 Sep;14(9):1171-7
references: 22898372
references: J Clin Oncol. 2004 Sep 1;22(17):3608-17
references: 15337811
references: Neurology. 1985 Feb;35(2):219-26
references: 3969210
references: Cell Biosci. 2011 Feb 25;1(1):8
references: 21711688
references: Nature. 2009 Jun 18;459(7249):1005-9
references: 19421193
references: Clin Cancer Res. 2007 Mar 15;13(6):1656-62
references: 17363518
references: Cancer. 2005 Jun 1;103(11):2344-8
references: 15844174
references: Nat Rev Cancer. 2002 Aug;2(8):563-72
references: 12154349
references: Breast. 2006 Apr;15(2):219-25
references: 16026983
references: Cancer. 2003 Jun 15;97(12):2972-7
references: 12784331
references: Science. 1982 Sep 10;217(4564):998-1003
references: 7112116
references: J Natl Cancer Inst. 2007 Feb 21;99(4):309-21
references: 17312308
references: Cancer Biol Ther. 2005 Aug;4(8):805-12
references: 16082183
references: Cell Mol Neurobiol. 2000 Feb;20(1):57-76
references: 10690502
references: Acta Oncol. 2006;45(2):196-201
references: 16546866
references: Cell. 2006 Nov 17;127(4):679-95
references: 17110329
references: Clin Exp Metastasis. 2005;22(3):237-46
references: 16158251
references: Semin Cancer Biol. 2011 Apr;21(2):107-12
references: 21167939