title: The signaling pathway of hypoxia inducible factor and its role in renal diseases.
abstract: It is well-documented that hypoxia inducible factor (HIF) is a key mediator of tissue and cellular adaptation to hypoxia. HIF-target genes are also involved in cellular apoptosis and profibrotic mechanisms. The role of HIF in diseases is not consistent. It is a risk factor for tumor progression, whereas it plays a protective role against ischemic hypofusion. For renal diseases, it is not always a risk or protective factor. Many factors are involved in the pathogenesis of renal diseases. It is reported that HIF not only increases hypoxia tolerance, but also regulates a lot of signaling pathways. In the past decades, a number of studies were also conducted to explore the association between HIF and the risk of renal diseases. However, the role of HIF in the development of renal diseases was not entirely clear. In this study, the signal transduction pathways of HIF and its role in the pathogenesis of renal diseases were reviewed.
authors: Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University , Nanjing, Jiangsu , China.
authors: Song
authors: S
authors: Mao
authors: Songming
authors: S
authors: Huang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D015687:Cell Hypoxia / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D007674:Kidney Diseases / Q000235:genetics* / Q000473:pathology; D060066:Protein Interaction Maps / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors