title: Formulation and evaluation of mefenamic acid emulgel for topical delivery.
abstract: Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic drugs. The objective of the study was to prepare emulgel of mefenamic acid, a NSAID, using Carbapol 940 as a gelling agent. Mentha oil and clove oil were used as penetration enhancers. The emulsion was prepared and it was incorporated in gel base. The formulations were evaluated for rheological studies, spreading coefficient studies, bioadhesion strength, skin irritation studies, in vitro release, ex vivo release studies, anti-inflammatory activity and analgesic activity. Formulation F2 and F4 showed comparable analgesic and anti-inflammatory activity when they compared with marketed diclofenac sodium gel. So, it can be concluded that topical emulgel of mefenamic acid posses an effective anti-inflammatory and analgesic activity.
authors: Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra, Punjab, India.
authors: Rachit
authors: R
authors: Khullar
authors: Deepinder
authors: D
authors: Kumar
authors: Nimrata
authors: N
authors: Seth
authors: Seema
authors: S
authors: Saini
keywords: Emulgel; Mefenamic acid; NSAIDs; Topical drug delivery
references: Drug Dev Ind Pharm. 2003 May;29(5):545-53
references: 12779284
references: J Pain Symptom Manage. 2007 Mar;33(3):342-55
references: 17349504
references: AAPS PharmSciTech. 2001 Feb 15;2(1):E-TN1
references: 14727885
references: AAPS J. 2004 Oct 11;6(3):e26
references: 15760111
references: Biol Pharm Bull. 2005 Jan;28(1):176-80
references: 15635188
references: AAPS PharmSciTech. 2009;10(2):368-75
references: 19340587
references: J Pain Res. 2010 Nov 10;3:223-33
references: 21197326
references: Br J Pharmacol. 1971 Jul;42(3):392-402
references: 4104654