title: Biomarker evaluation of self-reported condom use among women in HIV-discordant couples.
abstract: Self-reported condom use is a commonly collected statistic, yet its use in research studies may be inaccurate. We evaluated this statistic among women in HIV-discordant couples enrolled in a clinical trial in Nairobi, Kenya. Vaginal swabs were acquired from 125 women and tested for prostate-specific antigen (PSA), a biomarker for semen exposure, using an enzyme-linked immunosorbent assay. Ten (10%) of 98 women who reported 100% use of condoms in the previous month tested PSA positive. In a bivariate logistic regression analysis, among women who reported 100% condom use in the previous month, those with ≤8 years of school had significantly higher odds of testing PSA-positive (odds ratio [OR] = 8.39, 95% confidence interval [CI] 1.02-69.13) than women with more schooling. Our estimate may be conservative, as the ability to detect PSA may be limited to 24-48 hours after exposure. Less educated women may be a target group for counselling regarding reporting sexual behaviour in clinical trials.
authors: Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya.
authors: F
authors: F
authors: Mose
authors: L P
authors: LP
authors: Newman
authors: R
authors: R
authors: Njunguna
authors: H
authors: H
authors: Tamooh
authors: G
authors: G
authors: John-Stewart
authors: C
authors: C
authors: Farquhar
authors: J
authors: J
authors: Kiarie
mesh_terms: D015415:Biomarkers / Q000032:analysis; D017280:Condoms / Q000706:statistics & numerical data*; D004797:Enzyme-Linked Immunosorbent Assay; D005191:Family Characteristics; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000635:transmission; D006801:Humans; D007630:Kenya; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D057566:Self Report; D012661:Semen / Q000737:chemistry; D012959:Socioeconomic Factors
chemical_list: D015415:Biomarkers; D017430:Prostate-Specific Antigen
keywords: AIDS; HIV; PSA; biomarker; condom use; discordant couples; prevention; prostate-specific antigen; self-reported; semen exposure; sexual behaviour; transmission; women
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