title: An unusual case of acute psychosis in an adolescent.
abstract: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe form of encephalitis that has been identified within the context of acute neuropsychiatric manifestations. We report the case of an 18-year-old adolescent referred for a first episode of acute psychosis. The clinical picture rapidly deteriorated to a state of catatonia, decreased consciousness and autonomic instability. Detection of highly positive anti-NMDA-R antibodies confirmed the diagnosis of anti-NMDA-R encephalitis. Immunosuppressive treatment and repeated plasma exchange resulted in slow recovery. The literature on diagnosis and treatment of this specific type of encephalitis is reviewed.
authors: Department of Intensive Care, University Hospital Brussels, Belgium. Lies.verfaillie@uzbrussel.be
authors: L
authors: L
authors: Verfaillie
authors: V
authors: V
authors: Bissay
authors: N
authors: N
authors: Vanderbruggen
authors: E
authors: E
authors: Van Eetvelde
authors: P M
authors: PM
authors: Honoré
authors: H
authors: H
authors: Spapen
mesh_terms: D000293:Adolescent; D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000150:complications* / Q000628:therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D010951:Plasma Exchange; D011618:Psychotic Disorders / Q000209:etiology* / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone