title: Increased risk of acute pancreatitis in patients with chronic hemodialysis: a 4-year follow-up study.
abstract: BACKGROUND
  The risk of acute pancreatitis in patients on long-term peritoneal dialysis is higher as compared to the general population. However, the relationship between long-term hemodialysis and acute pancreatitis has never been established.
  
  
  OBJECTIVE
  We investigated the incidence of acute pancreatitis among patients on long-term hemodialysis in Taiwan to evaluate if there is a higher risk of acute pancreatitis in comparison to the general population.
  
  
  METHODS
  We utilized a National Health Insurance (NHI) claims data sample containing one million beneficiaries. We followed all adult beneficiaries from January 1, 2007 until December 31, 2010 to see if they had been hospitalized for acute pancreatitis during this period. We further identified patients on chronic hemodialysis and compared their risk of acute pancreatitis with the general population.
  
  
  RESULTS
  This study included 2603 patients with long-term hemodialysis and 773,140 patients without hemodialysis. After controlling for age, gender, Charlson Comorbidity Index Score, geographic region, socioeconomic status and urbanization level, the adjusted hazard ratio was 3.44 (95% Confidence interval, 2.5-4.7).
  
  
  CONCLUSIONS
  The risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population.
authors: Emergency Department, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
authors: Sheng-Wen
authors: SW
authors: Hou
authors: Yi-Kung
authors: YK
authors: Lee
authors: Chen-Yang
authors: CY
authors: Hsu
authors: Ching-Chih
authors: CC
authors: Lee
authors: Yung-Cheng
authors: YC
authors: Su
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
references: Gut. 2000 Mar;46(3):385-9
references: 10673301
references: Eur J Gastroenterol Hepatol. 2012 Jan;24(1):95-101
references: 22027700
references: Diabetes Care. 2012 May;35(5):1061-6
references: 22446175
references: Am J Surg. 1984 Dec;148(6):732-5
references: 6150657
references: J Chronic Dis. 1987;40(5):373-83
references: 3558716
references: Nephrol Dial Transplant. 2008 Apr;23(4):1401-5
references: 18065830
references: Gut. 1982 May;23(5):357-61
references: 6804312
references: Pancreas. 2012 Jul;41(5):696-702
references: 22699142
references: PLoS One. 2012;7(8):e44325
references: 22957007
references: Am J Gastroenterol. 1983 Mar;78(3):170-3
references: 6829538
references: Health Policy. 1997 Mar;39(3):225-39
references: 10165463
references: Pharmacoepidemiol Drug Saf. 2006 May;15(5):291-303
references: 16447304
references: J Clin Epidemiol. 1992 Jun;45(6):613-9
references: 1607900
references: Int J Pancreatol. 1992 Dec;12(3):263-9
references: 1283864
references: PLoS One. 2013 May 01;8(5):e62422
references: 23658727
references: Nephron. 1987;46(4):347-9
references: 3658062
references: Emerg Med J. 2013 Aug;30(8):620-2
references: 23620503
references: Am J Gastroenterol. 2005 Oct;100(10):2288-93
references: 16181382