title: Isolated abdominal circumference < 5% or estimated fetal weight 10 to 19% as predictors of small for gestational age infants.
abstract: OBJECTIVE
  To determine whether (1) isolated fetal abdominal circumference < 5% (AC5) in absence of growth restriction (estimated fetal weight < 10% [EFW10]) or (2) borderline fetal growth 10 to 19% (EFW10-19) predicts subsequent fetal and/or neonatal growth restriction.
  
  
  METHODS
  The authors performed a retrospective cohort study (January 2008 to December 2011) of women with singleton pregnancies between 26 and 36 weeks who had ≥ 1 growth ultrasound. Univariable and multivariable analyses were performed to determine the association between isolated AC5 or EFW10-19 with both subsequent sonographic diagnosis of EFW10 and neonatal diagnosis of small for gestational age (SGA). Test characteristics were calculated.
  
  
  RESULTS
  Out of the 10,642 pregnancies, prevalence of isolated AC5, EFW10-19, EFW10, and SGA were as follows: AC5, 5.31%; EFW10-19, 13.30%; EFW10, 7.95%; and SGA, 17.63%. While screening for SGA using EFW10 alone would miss 68.34% of SGA neonates, using isolated AC5 would identify an additional 16.15% of SGA neonates with a 3.7% false positive rate. Using EFW10-19 would identify an additional 40.20% of SGA neonates with a 9.0% false positive rate.
  
  
  CONCLUSIONS
  Fetuses with isolated AC5 or EFW10-19 are at an increased risk of growth restriction. Using isolated AC5 or composite EFW10-19 would identify SGA neonates that are missed using conventional sonographic definitions of growth restriction alone.
authors: Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Amy L
authors: AL
authors: Turitz
authors: Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Hayley
authors: H
authors: Quant
authors: Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Nadav
authors: N
authors: Schwartz
authors: Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Michal
authors: M
authors: Elovitz
authors: Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Jamie A
authors: JA
authors: Bastek
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging / Q000473:pathology*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000453:epidemiology*; D020567:Fetal Weight; D005865:Gestational Age; D006801:Humans; D007236:Infant, Small for Gestational Age; D009929:Organ Size; D011237:Predictive Value of Tests; D011247:Pregnancy; D015995:Prevalence; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal