title: Differential drug responses of circulating tumor cells within patient blood.
abstract: Personalized medicine holds great promise for cancer treatment, with the potential to address challenges associated with drug sensitivity and interpatient variability. Circulating tumor cells (CTC) can be useful for screening cancer drugs as they may reflect the severity and heterogeneity of primary tumors. Here we present a platform for rapidly evaluating individualized drug susceptibility. Treatment efficacy is evaluated directly in blood, employing a relevant environment for drug administration, and assessed by comparison of CTC counts in treated and control samples. Multiple drugs at varying concentrations are evaluated simultaneously to predict an appropriate therapy for individual patients.
authors: Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States.
authors: Andrew D
authors: AD
authors: Hughes
authors: Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States.
authors: Jocelyn R
authors: JR
authors: Marshall
authors: BioCytics, Inc., Huntersville, NC, United States; Carolina BioOncology Institute, PLLC, Huntersville, NC, United States.
authors: Eric
authors: E
authors: Keller
authors: BioCytics, Inc., Huntersville, NC, United States; Carolina BioOncology Institute, PLLC, Huntersville, NC, United States.
authors: John D
authors: JD
authors: Powderly
authors: BioCytics, Inc., Huntersville, NC, United States; Carolina BioOncology Institute, PLLC, Huntersville, NC, United States.
authors: Bryan T
authors: BT
authors: Greene
authors: Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States. Electronic address: mike.king@cornell.edu.
authors: Michael R
authors: MR
authors: King
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001772:Blood Cell Count; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000187:drug effects*; D057285:Precision Medicine
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Circulating tumor cell; Drug resistance; Personalized medicine
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