title: Hybrid CT angiography and quantitative 15O-water PET for assessment of coronary artery disease: comparison with quantitative coronary angiography.
abstract: OBJECTIVE
  CT angiography (CTA) can rule out significant stenoses with a very high reliability, whereas its ability to confirm significant stenoses is suboptimal. In contrast, measurements of myocardial blood flow (MBF) provide information on the haemodynamic consequences of stenoses. Therefore, a combination of the two might improve diagnostic accuracy. We conducted a head-to-head comparison of CTA, measurement of MBF by (15)O-water PET, and hybrid PET/CTA for the detection of significant coronary artery stenoses.
  
  
  METHODS
  The study group comprised 44 outpatients scheduled for invasive coronary angiography (ICA) with an intermediate pretest likelihood of coronary artery disease. The patients underwent 64-slice CTA and baseline and hyperaemic PET before ICA with quantitative coronary angiography analysis.
  
  
  RESULTS
  On a per-patient basis, the negative predictive values (NPV; 95% confidence intervals in parentheses) were 88 % (64 - 97%) for CTA, 90% (71 - 97%) for PET and 92% (74 - 98%) for PET/CTA, and the positive predictive values (PPV) were 71% (53 - 85%) for CTA, 87% (68 - 95%) for PET and 100% (84 - 100%) for PET/CTA. Similarly, on a per-vessel basis the NPVs (which were generally high) were 97% (94 - 100%) for CTA, 95 % (90 - 99%) for PET and 97% (95 - 100%) for PET/CTA, and the PPVs (which were lower, but higher with PET/CTA) were 53% (39 - 66%) for CTA, 53 % (40 - 66%) for PET and 85 % (73 - 97%) for PET/CTA. In six patients, CTA analysis was hampered by the presence of severe calcifications. However, with the addition of the PET data, all six patients were correctly categorized.
  
  
  CONCLUSIONS
  Cardiac quantitative hybrid PET/CTA imaging has better diagnostic accuracy than CTA alone and PET alone. CTA has a suboptimal PPV, suggesting that hybrid PET/CTA imaging should be used to assess the significance of coronary stenoses diagnosed by CTA.
authors: Department of Nuclear Medicine, OUH, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark, anders.thomassen@rsyd.dk.
authors: Anders
authors: A
authors: Thomassen
authors: Henrik
authors: H
authors: Petersen
authors: Axel C P
authors: AC
authors: Diederichsen
authors: Hans
authors: H
authors: Mickley
authors: Lisette O
authors: LO
authors: Jensen
authors: Allan
authors: A
authors: Johansen
authors: Oke
authors: O
authors: Gerke
authors: Poul-Erik
authors: PE
authors: Braad
authors: Per
authors: P
authors: Thayssen
authors: Mette M
authors: MM
authors: Høilund-Carlsen
authors: Werner
authors: W
authors: Vach
authors: Juhani
authors: J
authors: Knuuti
authors: Poul F
authors: PF
authors: Høilund-Carlsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water
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