title: Assessment of endothelial dysfunction in patients with impaired glucose tolerance during a cold pressor test.
abstract: The objective of this study is to explore changes in microvascular tone during a contralateral cold pressor test and to compare the results obtained in healthy subjects and in patients with impaired glucose tolerance (IGT) and type 2 diabetes. Low-amplitude fluctuations of skin temperature in the appropriate frequency ranges were used as a characteristic for the mechanism for vascular tone regulation. In total, 13 adults with type 2 diabetes aged 40-67 years and 18 adults with IGT aged 31-60 years participated in this pilot study. The control group included 12 healthy men and women aged 39-60 years. The response to the cold pressor test in patients with type 2 diabetes and with IGT differs essentially from that of healthy subjects in the endothelial frequency range. Endothelial dysfunction occurs in the preclinical stage of diabetes and manifests, in particular, as a disturbance of the endothelial part of vascular tone regulation.
authors: Perm State Medical Academy, Perm, Russian Federation.
authors: Elena
authors: E
authors: Smirnova
authors: Sergey
authors: S
authors: Podtaev
authors: Irina
authors: I
authors: Mizeva
authors: Evgenia
authors: E
authors: Loran
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003080:Cold Temperature; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D010865:Pilot Projects; D011236:Prediabetic State / Q000175:diagnosis / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012815:Signal Processing, Computer-Assisted; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature; D013817:Thermography; D013997:Time Factors; D014661:Vasoconstriction
keywords: Impaired glucose tolerance; endothelial dysfunction; skin temperature fluctuations; type 2 diabetes