title: Biochemical and physical signal gradients in hydrogels to control stem cell behavior.
abstract: Three-dimensional (3D) gradients of biochemical and physical signals in macroscale degradable hydrogels are engineered that can regulate photoencapsulated human mesenchymal stem cell (hMSC) behavior. This simple, cytocompatible, and versatile gradient system may be a valuable tool for researchers in biomaterials science to control stem cell fate in 3D and guide tissue regeneration.
authors: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors: Oju
authors: O
authors: Jeon
authors: Daniel S
authors: DS
authors: Alt
authors: Stephen W
authors: SW
authors: Linderman
authors: Eben
authors: E
authors: Alsberg
mesh_terms: D000464:Alginates / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D002478:Cells, Cultured; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008027:Light; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D011098:Polyglactin 910 / Q000737:chemistry; D015398:Signal Transduction; D023822:Tissue Engineering
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020100:Hydrogels; D011098:Polyglactin 910; D020723:Glucuronic Acid
keywords: alginate; biomaterials; gradients; hydrogels; stem cells; tissue engineering
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