title: The effect of polyhydroxylated alkaloids on maltase-glucoamylase.
abstract: One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.
authors: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.
authors: Qian
authors: Q
authors: Shang
authors: Junfeng
authors: J
authors: Xiang
authors: Hong
authors: H
authors: Zhang
authors: Qian
authors: Q
authors: Li
authors: Yalin
authors: Y
authors: Tang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D011485:Protein Binding; D011487:Protein Conformation; D051381:Rats; D013395:Sucrose / Q000378:metabolism; D000520:alpha-Glucosidases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D001786:Blood Glucose; D004791:Enzyme Inhibitors; D013395:Sucrose; D000520:alpha-Glucosidases
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