title: The role of goal cognitions, illness perceptions and treatment beliefs in self-reported adherence after kidney transplantation: a cohort study.
abstract: OBJECTIVE
  Nonadherence to immunosuppressive medication (IM) after kidney transplantation is related to poorer patient and graft outcomes; therefore research into modifiable factors associated with nonadherence is a priority. In this prospective cohort study we investigated whether changes in goal cognitions, illness perceptions, and treatment beliefs were related to self-reported medication adherence six months after kidney transplantation.
  
  
  METHODS
  Interviews were conducted with patients in the out-patient clinic six weeks (T1: n=113) and six months (T2: n=106) after transplantation. Self-reported adherence was measured using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS© Interview). The Brief Illness Perceptions Questionnaire, Beliefs about Medicines Questionnaire and questions on goal cognitions were also administered at both time points.
  
  
  RESULTS
  Self-reported nonadherence increased significantly between 6 weeks and 6 months after transplantation from 17% to 27%. Importance of medication adherence as a personal goal and self-efficacy to successfully carry out this goal decreased significantly over time. Perceived necessity of immunosuppressive medication was high but significantly decreased over time. Concerns about the medicines were low. There were no significant changes in illness perceptions or concerns over time. An increase in perceived graft longevity (timeline) was related to higher likelihood of nonadherence six months post-transplant. Furthermore, younger adult patients were more likely to be nonadherent six months after transplantation.
  
  
  CONCLUSIONS
  The self-reported nonadherence levels found in this study so soon after transplantation demonstrate the need for early and continued intervention after kidney transplantation in order to maximise adherence and consequently clinical outcomes. Changes in (unrealistic) beliefs regarding the longevity of the graft may offer a potential target for intervention among nonadherent patients.
authors: Department of Internal Medicine, Nephrology & Transplantation, Erasmus MC, Rotterdam, The Netherlands.
authors: Emma K
authors: EK
authors: Massey
authors: Mirjam
authors: M
authors: Tielen
authors: Mirjam
authors: M
authors: Laging
authors: Denise K
authors: DK
authors: Beck
authors: Roshni
authors: R
authors: Khemai
authors: Teun
authors: T
authors: van Gelder
authors: Willem
authors: W
authors: Weimar
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition; D015331:Cohort Studies; D003469:Culture; D005260:Female; D006040:Goals; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000523:psychology*; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D010465:Perception; D011446:Prospective Studies; D012648:Self Care; D020377:Self Efficacy; D057566:Self Report; D012927:Social Control, Informal; D011795:Surveys and Questionnaires
chemical_list: D007166:Immunosuppressive Agents
keywords: End stage renal disease; Medication adherence; Patient compliance; Self-management; Self-regulation