title: Ratio of metastatic to examined lymph nodes, a helpful staging system and independent prognostic factor of esophagogastric junction cancer.
abstract: BACKGROUND
  The incidence of the esophagogastric junction cancer is growing rapidly. The purpose of this study is to clarify the outcome of the ratio between metastatic and examined lymph nodes in esophagogastric junction cancer patients with or without 7 examined lymph nodes.
  
  
  METHODS
  A total of 3,481 patients who underwent operation are identified from the Surveillance, Epidemiology, and End Results database. Different lymph nodes resected groups are analyzed to test the lymph nodes ratio factor.
  
  
  RESULTS
  There are 2522 patients with 7 or more lymph nodes resected and 959 patients with less than 7 lymph nodes resected. Lymph nodes ratio and lymph node involvement are independent prognostic factors. But the lymph nodes ratio categories have a better prognostic value than the lymph node involvement categories. Compared with lymph node involvement categories, lymph nodes ratio categories represent patients with more homogeneous overall survival rate.
  
  
  CONCLUSIONS
  This study defines that the lymph nodes ratio is an independent prognostic factor for esophagogastric junction cancer. The lymph nodes ratio can prevent stage migration and may be a helpful system to predict the prognosis of esophagogastric junction cancer patients.
authors: Oncology Department, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors: Hao
authors: H
authors: Zhang
authors: Wei
authors: W
authors: Wang
authors: Dongmei
authors: D
authors: Diao
authors: Yao
authors: Y
authors: Cheng
authors: Yongchun
authors: Y
authors: Song
authors: Kun
authors: K
authors: Zhu
authors: Chengxue
authors: C
authors: Dang
mesh_terms: D000368:Aged; D004943:Esophagogastric Junction / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D016019:Survival Analysis
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