title: Negative feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction.
abstract: We present a minimal motif model for transmembrane cell signalling. The model assumes signalling events taking place in spatially distributed nanoclusters regulated by a birth/death dynamics. The combination of these spatio-temporal aspects can be modulated to provide a robust and high-fidelity response behaviour without invoking sophisticated modelling of the signalling process as a sequence of cascade reactions and fine-tuned parameters. Our results show that the fact that the distributed signalling events take place in nanoclusters with a finite lifetime regulated by local production is sufficient to obtain a robust and high-fidelity response.
authors: Departament de Física Fonamental, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
authors: M Ángeles
authors: MÁ
authors: Serrano
authors: Manuel
authors: M
authors: Jurado
authors: Ramon
authors: R
authors: Reigada
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
keywords: high-fidelity transduction; mitogen-activated protein kinase pathway; signalling nanoclusters; transmembrane signal transduction
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