title: A balance of interleukin-12 and -23 in cancer.
abstract: Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-γ, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the context of the tumor-inhibitory effects of IL-12, and tumor-promoting effects of IL-23, we discuss the use of anti-IL-12p/23 monoclonal antibodies (mAbs) in autoimmune inflammatory disorders and the alternative specific neutralization of IL-23.
authors: Immunology in Cancer and Infection Laboratory, Queensland Institute of Medical Research, Herston, 4006, Queensland, Australia.
authors: Shin Foong
authors: SF
authors: Ngiow
authors: Michele W L
authors: MW
authors: Teng
authors: Mark J
authors: MJ
authors: Smyth
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D063646:Carcinogenesis / Q000276:immunology*; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology*; D053759:Interleukin-23 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D053759:Interleukin-23; D018664:Interleukin-12
keywords: autoimmunity; cancer; cytokine; inflammation