title: Randomised in situ study on the efficacy of a tin/chitosan toothpaste on erosive-abrasive enamel loss.
abstract: Tin is a notable anti-erosive agent, and the biopolymer chitosan has also shown demineralisation-inhibiting properties. Therefore, the anti-erosive/anti-abrasive efficacy of the combination of both compounds was tested under in situ conditions. Twenty-seven volunteers were included in a randomised, double-blind, three-cell crossover in situ trial. Enamel specimens were recessed on the buccal aspects of mandibular appliances, extraorally demineralised (6 × 2 min/day) and intraorally treated with toothpaste slurries (2 × 2 min/day). Within the slurry treatment time, one-half of the specimens received additional intraoral brushing (5 s, 2.5 N). The tested toothpastes included a placebo toothpaste, an experimental NaF toothpaste (1,400 ppm F(-)) and an experimental F/Sn/chitosan toothpaste (1,400 ppm F(-), 3,500 ppm Sn(2+), 0.5% chitosan). The percentage reduction of tissue loss (slurry exposure/slurry exposure + brushing) compared to placebo was 19.0 ± 47.3/21.3 ± 22.4 after use of NaF and 52.5 ± 30.9/50.2 ± 34.3 after use of F/Sn/chitosan. F/Sn/chitosan was significantly more effective than NaF (p ≤ 0.001) and showed good efficacy against erosive and erosive-abrasive tissue loss. This study suggests that the F/Sn/chitosan toothpaste could provide good protection for patients who frequently consume acidic foodstuffs.
authors: Department of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University, Giessen, Germany.
authors: N
authors: N
authors: Schlueter
authors: J
authors: J
authors: Klimek
authors: C
authors: C
authors: Ganss
mesh_terms: D000588:Amines / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use*; D048271:Chitosan / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D010919:Placebos; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000627:therapeutic use; D017971:Tin Compounds / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use; D014072:Tooth Abrasion / Q000517:prevention & control*; D014077:Tooth Erosion / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000588:Amines; D002614:Chelating Agents; D010919:Placebos; D017971:Tin Compounds; D014002:Tin Fluorides; D014100:Toothpastes; C023599:stannous chloride; D012969:Sodium Fluoride; D048271:Chitosan