title: Synthesis of a rotaxane Cu(I) triazolide under aqueous conditions.
abstract: We describe the serendipitous isolation of a stable, neutral, monomeric mechanically interlocked Cu(I) triazolide under aqueous conditions. This "trapped" intermediate of the CuAAC catalytic cycle is sterically protected from reprotonation by the rotaxane architecture, which renders the Cu(I)-C bond stable toward moisture and air--even carboxylic acids protonate the Cu(I)-C bond only slowly. The isolation of this remarkably stable Cu(I) organometallic points toward potential applications of mechanical bonding in the study of reactive intermediates.
authors: School of Biological Sciences, Queen Mary University of London , Joseph Priestly Building, Mile End Road, London E1 4NS, U.K.
authors: Joby
authors: J
authors: Winn
authors: Aleksandra
authors: A
authors: Pinczewska
authors: Stephen M
authors: SM
authors: Goldup
mesh_terms: D003300:Copper / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D043862:Rotaxanes; D014230:Triazoles; D014867:Water; D003300:Copper