title: DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment.
abstract: Every day, cells are faced with thousands of DNA lesions, which have to be repaired to preserve cell survival and function. DNA repair is more or less accurate and could result in genomic instability and cancer. We review here the current knowledge of the links between molecular features, treatment, and DNA repair in multiple myeloma (MM), a disease characterized by the accumulation of malignant plasma cells producing a monoclonal immunoglobulin. Genetic instability and abnormalities are two hallmarks of MM cells and aberrant DNA repair pathways are involved in disease onset, primary translocations in MM cells, and MM progression. Two major drugs currently used to treat MM, the alkylating agent Melphalan and the proteasome inhibitor Bortezomib act directly on DNA repair pathways, which are involved in response to treatment and resistance. A better knowledge of DNA repair pathways in MM could help to target them, thus improving disease treatment.
authors: CHU Montpellier; Institute of Research in Biotherapy; Montpellier, France; INSERM; U1040; Montpellier, France.
authors: Claire
authors: C
authors: Gourzones-Dmitriev
authors: Alboukadel
authors: A
authors: Kassambara
authors: Surinder
authors: S
authors: Sahota
authors: Thierry
authors: T
authors: Rème
authors: Jérôme
authors: J
authors: Moreaux
authors: Pascal
authors: P
authors: Bourquard
authors: Dirk
authors: D
authors: Hose
authors: Philippe
authors: P
authors: Pasero
authors: Angelos
authors: A
authors: Constantinou
authors: Bernard
authors: B
authors: Klein
mesh_terms: D063646:Carcinogenesis / Q000235:genetics* / Q000473:pathology*; D004260:DNA Repair / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009101:Multiple Myeloma / Q000235:genetics* / Q000628:therapy*
keywords: DNA repair; bortezomib; drug resistance; genetic instability; homologous recombination; melphalan; multiple myeloma; non-homologous end joining
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