title: Relationship between 5' UTR length and gene expression pattern in chicken.
abstract: The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and non-amniote vertebrates. Here, we carried out a systematic study of the relationship between 5' UTR length and gene expression pattern in the chicken genome. We found that gene 5' UTRs lengths show a negative correlation with gene expression levels and gene expression breadths significantly. The relevance of 5' UTR length to expression pattern can not be a consequence of transcription-associated mutations. We also found that gene 5' UTR length shows a weakly positive correlation with gene tissue specificity. Another intriguing finding is that genes with 5' UTR length <30 bp have highest expression level, highest expression breadth, and lowest tissue specificity in chicken. We argued that selection is likely involved in shaping 5' UTR length in the chicken genome.
authors: Department of Biological Technology, Nanchang Normal University, Nanchang, Jiangxi, China, rys8323571@yahoo.com.cn.
authors: You S
authors: YS
authors: Rao
authors: Zhang F
authors: ZF
authors: Wang
authors: Xue W
authors: XW
authors: Chai
authors: Qing H
authors: QH
authors: Nie
authors: Xi Q
authors: XQ
authors: Zhang
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D000818:Animals; D002645:Chickens / Q000235:genetics*; D016678:Genome; D009928:Organ Specificity; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D020121:5' Untranslated Regions
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