title: Endostatin levels and the risk of subsequent preeclampsia.
abstract: OBJECTIVE
  To evaluate endostatin, an anti-angiogenic factor, in relation to the risk of preeclampsia (PE).
  
  
  METHODS
  In this case control study, serum samples were collected at 11-17 weeks and 18-26 weeks' gestation. Endostatin levels were expressed as adjusted multiples of the median (MoM). Logistic regression was used to calculate adjusted odds ratios (aORs) for the prediction of PE.
  
  
  RESULTS
  A total of 77 women with PE and 150 controls were studied. Endostatin levels were significantly higher in women with PE compared to controls in both the first and the second trimester. At a cut-off level of 75th percentile of endostatin MoMs, the aORs for PE were 1.33 (95% confidence interval [CI], 0.68-2.58) at 11-17 weeks and 1.77 (95% CI, 0.94-3.34) at 18-26 weeks, after adjustment for ethnicity and chronic hypertension. The aORs for early-onset PE were 3.51 (95% CI, 1.18-10.43) at 11-17 weeks and 2.17 (95% CI, 0.67-7.06) at 18-26 weeks.
  
  
  CONCLUSIONS
  Higher endostatin levels are associated with an increased risk of early onset PE. Endostatin alone, however, has a poor predictive value for clinical usefulness.
authors: Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, 3175 Cote Ste-Catherine, Montreal, Quebec H3T 1C5, Canada.
authors: Sarah
authors: S
authors: Thissier-Levy
authors: Isabelle
authors: I
authors: Boucoiran
authors: Zhong-Cheng
authors: ZC
authors: Luo
authors: Anne-Monique
authors: AM
authors: Nuyt
authors: Pierre
authors: P
authors: Julien
authors: William D
authors: WD
authors: Fraser
authors: Francois
authors: F
authors: Audibert
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D043169:Endostatins / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D018570:Risk Assessment
chemical_list: D043169:Endostatins
keywords: Endostatin; Preeclampsia; Pregnancy; Screening