title: Waol A,trans-dihydrowaol A, andcis-dihydrowaol A: polyketide-derived γ-lactones from aVolutellaspecies.
abstract: An organic extract of a filamentous fungus (MSX 58801), identified as aVolutellasp. (Hypocreales, Ascomycota), displayed moderate cytotoxic activity against NCI-H460 human large cell lung carcinoma. Bioactivity-directed fractionation led to the isolation of three γ-lactones having the furo[3,4-b]pyran-5-one bicyclic ring system [waol A (1),trans-dihydrowaol A (2), andcis-dihydrowaol A (3)]. The structures were elucidated using a set of spectroscopic and spectrometric techniques; the absolute configuration of2was established via a modified Mosher's ester method. Compounds1and2were evaluated for cytotoxicity against a human cancer cell panel.
authors: University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, Greensboro, NC 27402, United States.
authors: Tamam
authors: T
authors: El-Elimat
authors: Mario
authors: M
authors: Figueroa
authors: Huzefa A
authors: HA
authors: Raja
authors: Audrey F
authors: AF
authors: Adcock
authors: David J
authors: DJ
authors: Kroll
authors: Steven M
authors: SM
authors: Swanson
authors: Mansukh C
authors: MC
authors: Wani
authors: Cedric J
authors: CJ
authors: Pearce
authors: Nicholas H
authors: NH
authors: Oberlies
keywords: Cytotoxicty; Filamentous Fungi; Polyketide; Waol A; γ-Lactone
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