title: Age-related changes in the structure and function of prefrontal cortex-amygdala circuitry in children and adolescents: a multi-modal imaging approach.
abstract: The uncinate fasciculus is a major white matter tract that provides a crucial link between areas of the human brain that underlie emotion processing and regulation. Specifically, the uncinate fasciculus is the major direct fiber tract that connects the prefrontal cortex and the amygdala. The aim of the present study was to use a multi-modal imaging approach in order to simultaneously examine the relation between structural connectivity of the uncinate fasciculus and functional activation of the amygdala in a youth sample (children and adolescents). Participants were 9 to 19years old and underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). Results indicate that greater structural connectivity of the uncinate fasciculus predicts reduced amygdala activation to sad and happy faces. This effect is moderated by age, with younger participants exhibiting a stronger relation. Further, decreased amygdala activation to sad faces predicts lower internalizing symptoms. These results provide important insights into brain structure-function relationships during adolescence, and suggest that greater structural connectivity of the uncinate fasciculus may facilitate regulation of the amygdala, particularly during early adolescence. These findings also have implications for understanding the relation between brain structure, function, and the development of emotion regulation difficulties, such as internalizing symptoms.
authors: Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA. Electronic address: jrswartz@umich.edu.
authors: Johnna R
authors: JR
authors: Swartz
authors: Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USA. Electronic address: melisa_carrasco@urmc.rochester.edu.
authors: Melisa
authors: M
authors: Carrasco
authors: Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA. Electronic address: leejilli@umich.edu.
authors: Jillian Lee
authors: JL
authors: Wiggins
authors: Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI 48202, USA; Department of Pediatrics, Wayne State University, Detroit, MI 48202, USA. Electronic address: moriah@wayne.edu.
authors: Moriah E
authors: ME
authors: Thomason
authors: Department of Psychology, University of Michigan, Ann Arbor, MI 48104, USA; Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48104, USA; Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48104, USA. Electronic address: csmonk@umich.edu.
authors: Christopher S
authors: CS
authors: Monk
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D000679:Amygdala / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D009413:Nerve Fibers, Myelinated / Q000502:physiology / Q000648:ultrastructure; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Adolescence; Development; Diffusion tensor imaging; Emotion; Internalizing; fMRI
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