title: Association of serum total testosterone concentration with skeletal muscle mass in men under hemodialysis.
abstract: OBJECTIVE
  Although skeletal muscle wasting can occur in chronic kidney diseases, its relationship with the serum testosterone concentration remains uncertain. This study investigates the relationship between serum testosterone and skeletal muscle mass in men under hemodialysis (HD).
  
  
  METHODS
  Sixty men aged between 41 and 89 years undergoing HD for 15.0 ± 8.1 years were enrolled for this study. The muscle areas of the thigh (TMA) and abdomen (AMA) were measured by computed tomography (CT), and the association between these muscle areas and serum total testosterone was examined with adjustment of age and other nutritional variables.
  
  
  RESULTS
  The mean serum total testosterone in our HD patients (6.33 ± 2.90 ng/mL) was not lower than that of the Japanese general population, but showed a positive correlation with TMA (r = 0.39, p < 0.05), AMA (r = 0.52, p < 0.001), serum creatinine (r = 0.33, p < 0.05), and the creatinine generation rate (r = 0.26, p < 0.05). Serum total testosterone was inversely correlated with age (r = -0.32, p < 0.05), CRP (r = -0.31, p < 0.05), and IL-6 (r = -0.24, p < 0.05). A multiple-regression analysis showed both serum total testosterone and age to be an independent determinant of the muscle mass in these patients.
  
  
  CONCLUSIONS
  This study identified testosterone as a determinant of muscle mass in HD men.
authors: Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan.
authors: Gloria
authors: G
authors: Kojo
authors: Takuya
authors: T
authors: Yoshida
authors: Sakae
authors: S
authors: Ohkawa
authors: Mari
authors: M
authors: Odamaki
authors: Akihiko
authors: A
authors: Kato
authors: Takako
authors: T
authors: Takita
authors: Yukitaka
authors: Y
authors: Maruyama
authors: Hiromichi
authors: H
authors: Kumagai
mesh_terms: D000009:Abdominal Muscles / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy*; D013739:Testosterone / Q000097:blood*; D013848:Thigh / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D015850:Interleukin-6; D013739:Testosterone; D002097:C-Reactive Protein; D003404:Creatinine
references: Circulation. 2007 Jul 3;116(1):85-97
references: 17606856
references: J Clin Endocrinol Metab. 2001 Feb;86(2):724-31
references: 11158037
references: J Nephrol. 2012 Jan-Feb;25(1):31-42
references: 21748720
references: Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7
references: 15075918
references: Eur J Endocrinol. 2011 Nov;165(5):687-701
references: 21852391
references: J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8
references: 15240608
references: Mech Ageing Dev. 1999 Mar 1;107(2):123-36
references: 10220041
references: Kidney Int. 2008 Feb;73(4):391-8
references: 18094682
references: Int J Urol. 2005 Sep;12(9):810-4
references: 16201977
references: Kidney Int. 2003 Jan;63(1):291-7
references: 12472795
references: Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E284-94
references: 12110533
references: Clin Exp Rheumatol. 1993 Mar-Apr;11(2):157-62
references: 8508557
references: Atherosclerosis. 2011 Jun;216(2):446-51
references: 21414625
references: Endocr Rev. 2005 Oct;26(6):833-76
references: 15901667
references: Clin J Am Soc Nephrol. 2010 Nov;5(11):2018-23
references: 20651153
references: Rheum Dis Clin North Am. 2000 Nov;26(4):825-39
references: 11084946
references: Clin Chim Acta. 2012 Apr 11;413(7-8):803-7
references: 22293276
references: J Sex Med. 2007 Jul;4(4 Pt 1):1056-69
references: 17627750
references: Am J Clin Nutr. 2010 Apr;91(4):1128S-1132S
references: 20181807
references: Nephrol Dial Transplant. 2011 Jan;26(1):184-90
references: 20624775
references: J Am Soc Nephrol. 2009 Mar;20(3):613-20
references: 19144759
references: Int Urol Nephrol. 2014 Jan;46(1):129-40
references: 23703546
references: Ann N Y Acad Sci. 1999 Jun 22;876:426-9
references: 10415638
references: Nephrol Dial Transplant. 2011 Sep;26(9):2971-7
references: 21427069
references: Am J Clin Nutr. 2000 Feb;71(2):485-90
references: 10648262
references: Mayo Clin Proc. 2013 May;88(5):479-86
references: 23562348
references: Heart. 2011 Jun;97(11):870-5
references: 21177660
references: BMJ. 2000 Jul 22;321(7255):199-204
references: 10903648
references: Int Urol Nephrol. 2013 Dec;45(6):1747-52
references: 23793618
references: J Clin Endocrinol Metab. 2003 Nov;88(11):5240-7
references: 14602756
references: J Am Soc Nephrol. 1996 May;7(5):780-5
references: 8738814
references: Am J Kidney Dis. 2003 Aug;42(2):295-302
references: 12900811
references: Artif Organs. 1997 Aug;21(8):864-72
references: 9247176