title: Elevated serum levels of interleukin-17A in uveitis patients.
abstract: OBJECTIVE
  T helper 17 cells (Th17) are one of the main pathogenic effectors in autoimmune uveitis, and IL-17A is the signature cytokine of Th17 cells. This study aims to assess serum IL-17A levels in patients with autoimmune uveitis and evaluate associations between IL-17A levels and disease characteristics.
  
  
  METHODS
  Serum IL-17A levels from 87 autoimmune uveitis patients and 60 healthy controls were assessed using an enzyme-linked immunosorbent assay. Among this cohort, 9 patients were followed longitudinally for IL-17A levels during active and inactive stages of their disease.
  
  
  RESULTS
  Median serum IL-17A levels were higher among uveitis patients compared to controls (p < 0.0001). Moreover, IL-17A levels were elevated among uveitis patients with active disease compared to those with inactive disease (p = 0.0202). Among the 9 patients followed longitudinally, IL-17A levels were elevated during active disease compared to the inactive stage (p = 0.0078).
  
  
  CONCLUSIONS
  Serum IL-17A levels are elevated in uveitis patients, particularly in active uveitis.
authors: Laboratory of Clinical Immunology and.
authors: Shayma
authors: S
authors: Jawad
authors: Baoying
authors: B
authors: Liu
authors: Elvira
authors: E
authors: Agron
authors: Robert B
authors: RB
authors: Nussenblatt
authors: H Nida
authors: HN
authors: Sen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D002648:Child; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D058504:Th17 Cells / Q000276:immunology; D014605:Uveitis / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D055815:Young Adult
chemical_list: D020381:Interleukin-17
references: Am J Ophthalmol. 2005 Sep;140(3):509-16
references: 16196117
references: Ocul Immunol Inflamm. 2009 May-Jun;17(3):160-9
references: 19585358
references: Br J Rheumatol. 1992 May;31(5):299-308
references: 1581771
references: Immunol Res. 2008;42(1-3):41-50
references: 18629448
references: Gut. 2003 Jan;52(1):65-70
references: 12477762
references: Clin Rheumatol. 2011 Sep;30(9):1201-7
references: 21874405
references: Ophthalmology. 2013 Apr;120(4):777-87
references: 23290985
references: Cytokine. 2008 Sep;43(3):402-7
references: 18701318
references: Semin Immunopathol. 2008 Apr;30(2):135-43
references: 18317764
references: Am J Ophthalmol. 2013 Jun;155(6):1068-1074.e1
references: 23497844
references: Lancet. 1990 May 5;335(8697):1078-80
references: 1970380
references: Jpn J Ophthalmol. 2011 Sep;55(5):565-575
references: 21750969
references: Nat Med. 2007 Jun;13(6):711-8
references: 17496900
references: Histol Histopathol. 2011 Sep;26(9):1145-51
references: 21751146
references: Scand J Rheumatol. 2002;31(4):205-10
references: 12369651
references: J Allergy Clin Immunol. 2007 May;119(5):1218-24
references: 17335887
references: Clin Immunol. 2008 Jun;127(3):385-93
references: 18373953
references: J Immunol. 2011 Mar 15;186(6):3373-82
references: 21307296
references: Am J Ophthalmol. 2011 Aug;152(2):177-182.e1
references: 21570674
references: J Korean Med Sci. 2011 Jul;26(7):938-44
references: 21738349
references: Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3058-64
references: 18579762
references: Mol Vis. 2010 May 19;16:880-6
references: 20508866
references: J Rheumatol. 2007 Aug;34(8):1647-9
references: 17696283
references: PLoS One. 2011 Mar 30;6(3):e18139
references: 21479174
references: Med Sci Monit. 2011 Apr;17(4):CR227-34
references: 21455110
references: Arthritis Res Ther. 2010;12(5):R196
references: 20961415
references: Clin Rheumatol. 2011 Feb;30(2):269-73
references: 21161669
references: J Chin Med Assoc. 2012 Jul;75(7):303-8
references: 22824043
references: Rev Bras Reumatol. 2012 Aug;52(4):536-44
references: 22885421
references: Front Immunol. 2012 Jun 04;3:129
references: 22675324
references: J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):330-2
references: 17641855
references: Sci Transl Med. 2010 Oct 6;2(52):52ra72
references: 20926833