title: In vivo1H magnetic resonance spectroscopy in young-adult daily marijuana users.
abstract: To date, there has been little work describing the neurochemical profile of young, heavy marijuana users. In this study, we examined 27 young-adult marijuana users and 26 healthy controls using single-voxel magnetic resonance spectroscopy on a 3 T scanner. The voxel was placed in the dorsal striatum, and estimated concentrations of glutamate + glutamine,myo-inositol, taurine + glucose, total choline and totalN-acetylaspartate were examined between groups. Therewere no overall group effects, but two metabolites showed group by sex interactions. Lower levels of glutamate + glutamine (scaled to total creatine) were observed in female, but not male, marijuana users compared to controls. Higher levels ofmyo-inositol were observed in female users compared to female non-users and to males in both groups. Findings are discussed in relation to patterns of corticostriatal connectivity and function, in the context of marijuana abuse.
authors: Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
authors: Ryan L
authors: RL
authors: Muetzel
authors: Małgorzata
authors: M
authors: Marjańska
authors: Paul F
authors: PF
authors: Collins
authors: Mary P
authors: MP
authors: Becker
authors: Romain
authors: R
authors: Valabrègue
authors: Edward J
authors: EJ
authors: Auerbach
authors: Kelvin O
authors: KO
authors: Lim
authors: Monica
authors: M
authors: Luciana
keywords: Adolescence; Basal ganglia; Cannabis; Glutamate
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