title: Alkyne-azide "click" chemistry in designing nanocarriers for applications in biology.
abstract: The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of "click" chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.
authors: Montreal Heart Institute, Research Center, 5000 Bélanger Est, Montréal, QC H1T 1C8, Canada.
authors: Pramod K
authors: PK
authors: Avti
authors: Dusica
authors: D
authors: Maysinger
authors: Ashok
authors: A
authors: Kakkar
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry / Q000379:methods*; D008928:Mitochondria / Q000737:chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides
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