title: The pH-sensitive polyampholyte nanogels: inclusion of carbon nanotubes for improved drug loading.
abstract: We report a simple and facile method to prepare a novel pH sensitive polyampholyte nanogel by copolymerizing vinylimidazole (VIM) with acrylic acid (AA) using functionalized single-walled carbon nanotubes (f-SWCNTs) (as reinforcing material) and cyanuric chloride via an intermolecular quaternization reaction. The polyampholyte nanogels have been characterized by various microscopic and spectroscopic methods. These studies reveal that incorporation of nanotubes in cross-linked copolymer of poly(vinylimidazole-co-acrylic acid) (PVI-co-AA) form polyampholyte nanogel with enhanced physical properties. The thermal experiments show that the introduction of f-SWCNTs into PVI-co-AA has significant impact on the thermal stability of nanogels. The rheological study showed that the nanogel is more viscoelastic than native gel. MTT assay indicates that the prepared polyampholyte gels possess biocompatibility and cell viability. The nanogel is also useful material to load water-soluble drug such as promethazine hydrochloride. The releasing profile of the drug from the nanogel clearly shows the pH-sensitive property of the material.
authors: Polymer Division, Council of Scientific and Industrial Research (CSIR) - Central Leather Research Institute (CLRI), Adyar, Chennai 600020, Tamil Nadu, India.
authors: Rajavelu Murali
authors: RM
authors: Sankar
authors: Kamal Mohamed
authors: KM
authors: Seeni Meera
authors: Debasis
authors: D
authors: Samanta
authors: Panneerselvam
authors: P
authors: Jithendra
authors: Asit Baran
authors: AB
authors: Mandal
authors: Sellamuthu N
authors: SN
authors: Jaisankar
mesh_terms: D000665:Ampholyte Mixtures / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D006358:Hot Temperature; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D048288:Imidazolines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011145:Polyvinyls / Q000737:chemistry; D011398:Promethazine / Q000008:administration & dosage; D012212:Rheology; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014783:Viscosity
chemical_list: D000665:Ampholyte Mixtures; D004337:Drug Carriers; D020100:Hydrogels; D048288:Imidazolines; D037742:Nanotubes, Carbon; D011145:Polyvinyls; C521626:polyvinylimidazoline; D011398:Promethazine
keywords: Carbon nanotubes; Drug release; Nanogel; Poly(vinylimidazole); Polyampholyte