title: [Use of the PMSI for the detection of adverse drug reactions].
abstract: OBJECTIVE
  To evaluate the performance of a query on international classification of diseases 10(th) version (ICD10) codes in the database of the programme for the medicalisation of information systems (programme de médicalisation des systèmes d'information, PMSI) to identify serious adverse drug reactions (ADR).
  
  
  METHODS
  The query concerned hospital stays of patients discharged from the French University Hospital of Rennes in 2009. All the hospitalization summaries including a selected ICD10 code were analysed to validate ADR.
  
  
  RESULTS
  Out of 383 cases, 142 cases were validated (37.1%). Performance of some ICD10 codes was particularly interesting, above 40% (T88.6, L27.0, J70.4, G62.0 and N14.1) and 79.5% of the ADR were detected by these five codes. During the study period, 98 ADR of the same type were spontaneously reported by physicians, 22 of which were common with the ICD10 query.
  
  
  CONCLUSIONS
  The use of PMSI can be a tool for signal detection of serious ADR, in addition to spontaneous reporting.
authors: Centre régional de Pharmacovigilance, CHU Pontchaillou, Rennes, France.
authors: Marie-Noëlle
authors: MN
authors: Osmont
authors: Marc
authors: M
authors: Cuggia
authors: Elisabeth
authors: E
authors: Polard
authors: Christine
authors: C
authors: Riou
authors: Frédéric
authors: F
authors: Balusson
authors: Emmanuel
authors: E
authors: Oger
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D059019:Clinical Coding; D016208:Databases, Factual / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis*; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D016347:Medical Records Systems, Computerized / Q000706:statistics & numerical data*; D060735:Pharmacovigilance