title: PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor.
authors: Departments of aGenetics bBioengineering, Stanford University Medical Center, Stanford, California, USA cBreakthrough Cancer Research Unit, Pangaea Biotech, Dexeus University Institute dMedical Oncology Service, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Barcelona, Spain.
authors: Ugur
authors: U
authors: Hodoglugil
authors: Michelle W
authors: MW
authors: Carrillo
authors: Joan M
authors: JM
authors: Hebert
authors: Niki
authors: N
authors: Karachaliou
authors: Rafael C
authors: RC
authors: Rosell
authors: Russ B
authors: RB
authors: Altman
authors: Teri E
authors: TE
authors: Klein
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics*; D017326:Clinical Trials, Phase III as Topic; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D058990:Molecular Targeted Therapy; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D047428:Protein Kinase Inhibitors; C512478:EGFR protein, human; D066246:ErbB Receptors
references: Br J Cancer. 2007 Apr 23;96(8):1191-6
references: 17387341
references: Nat Rev Cancer. 2005 May;5(5):341-54
references: 15864276
references: Lung Cancer. 2006 Nov;54(2):201-7
references: 16956694
references: Curr Drug Targets. 2010 Jul;11(7):851-64
references: 20388064
references: J Clin Oncol. 2008 Apr 1;26(10):1742-51
references: 18375904
references: N Engl J Med. 2009 Sep 3;361(10):947-57
references: 19692680
references: Cancer Sci. 2007 Dec;98(12):1817-24
references: 17888036
references: J Clin Oncol. 2012 Apr 1;30(10):1122-8
references: 22370314
references: N Engl J Med. 2005 Jul 14;353(2):123-32
references: 16014882
references: Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2070-5
references: 18227510
references: J Thorac Oncol. 2008 Aug;3(8):832-9
references: 18670300
references: Hum Genet. 2012 Dec;131(12):1877-88
references: 22886559
references: Proc Natl Acad Sci U S A. 1983 Mar;80(5):1337-41
references: 6298788
references: Clin Cancer Res. 2011 Mar 1;17(5):1169-80
references: 21248300
references: J Clin Oncol. 2008 Mar 1;26(7):1119-27
references: 18309947
references: J Clin Pathol. 2011 Nov;64(11):947-52
references: 21725039
references: Clin Cancer Res. 2011 Mar 1;17(5):1160-8
references: 21233402
references: J Clin Oncol. 2005 Sep 1;23(25):5900-9
references: 16043828
references: Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37
references: 11252954
references: Cancer Treat Rev. 2013 Aug;39(5):489-97
references: 23022519
references: Br J Cancer. 2006 Dec 4;95(11):1483-9
references: 17106442
references: Cancer Prev Res (Phila). 2008 Aug;1(3):156-60
references: 19138950
references: N Engl J Med. 2007 Nov 15;357(20):2040-8
references: 18003960
references: N Engl J Med. 2008 Mar 13;358(11):1160-74
references: 18337605
references: N Engl J Med. 2010 Jun 24;362(25):2380-8
references: 20573926
references: Nat Rev Clin Oncol. 2009 Sep;6(9):519-27
references: 19636327
references: Gene. 2006 Jan 17;366(1):2-16
references: 16377102
references: Crit Rev Oncol Hematol. 2001 Apr;38(1):17-23
references: 11255078
references: Pharmacogenomics. 2012 May;13(7):789-802
references: 22594511
references: Nucleic Acids Res. 2002 Jan 1;30(1):38-41
references: 11752248
references: J Thorac Oncol. 2012 Oct;7(10):1490-502
references: 22982650
references: Nat Genet. 2005 Dec;37(12):1315-6
references: 16258541
references: N Engl J Med. 2008 Sep 11;359(11):1116-27
references: 18784101
references: J Clin Oncol. 2011 Nov 1;29(31):4113-20
references: 21969500
references: Cancer Res. 2006 Aug 15;66(16):7854-8
references: 16912157
references: Drugs. 2000;60 Suppl 1:15-23; discussion 41-2
references: 11129168
references: Clin Cancer Res. 2009 Jan 15;15(2):460-7
references: 19147750
references: Lancet Oncol. 2011 Aug;12(8):735-42
references: 21783417
references: Carcinogenesis. 2012 Jul;33(7):1270-6
references: 22510280
references: N Engl J Med. 2009 Sep 3;361(10):958-67
references: 19692684
references: Lancet Oncol. 2010 Feb;11(2):121-8
references: 20022809
references: Pharmacogenomics J. 2008 Apr;8(2):129-38
references: 17375033
references: Nat Rev Cancer. 2007 Mar;7(3):169-81
references: 17318210
references: J Biol Chem. 2008 Apr 18;283(16):10698-706
references: 18281283
references: Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50
references: 20952405
references: Lung Cancer. 2007 Oct;58(1):95-103
references: 17610986
references: J Clin Oncol. 2004 Mar 1;22(5):785-94
references: 14990633
references: N Engl J Med. 2005 Feb 24;352(8):786-92
references: 15728811
references: N Engl J Med. 2005 Jul 14;353(2):172-87
references: 16014887
references: Eur J Pharmacol. 2007 Sep 10;570(1-3):175-81
references: 17597605
references: Lancet. 2005 Oct 29-Nov 4;366(9496):1527-37
references: 16257339
references: J Clin Oncol. 2008 Mar 20;26(9):1472-8
references: 18349398
references: Clin Pharmacol Ther. 2012 Oct;92(4):414-7
references: 22992668
references: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20932-7
references: 18093943
references: N Engl J Med. 2009 Apr 2;360(14):1408-17
references: 19339720
references: J Clin Oncol. 2012 Feb 1;30(4):433-40
references: 22215752
references: Nat Rev Clin Oncol. 2010 Sep;7(9):493-507
references: 20551942
references: Oncol Lett. 2012 Mar;3(3):713-717
references: 22740981
references: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
references: 18287387
references: Lung Cancer. 2009 Oct;66(1):114-9
references: 19201048
references: J Clin Oncol. 2006 Jul 20;24(21):3340-6
references: 16785471
references: Lancet Oncol. 2008 Oct;9(10):962-72
references: 18804418
references: Cancer Res. 2008 Apr 1;68(7):2106-11
references: 18381415
references: Int J Cancer. 2007 Mar 15;120(6):1239-47
references: 17192902
references: Sci Transl Med. 2011 Mar 23;3(75):75ra26
references: 21430269
references: Cancer Cell. 2010 Jan 19;17(1):77-88
references: 20129249
references: Cell. 2012 Sep 14;150(6):1107-20
references: 22980975
references: Clin Cancer Res. 2008 Mar 1;14(5):1296-302
references: 18316547
references: Cancer Res. 2013 Apr 15;73(8):2428-34
references: 23382048
references: N Engl J Med. 2008 Jul 24;359(4):366-77
references: 18596266
references: J Clin Oncol. 2004 Mar 1;22(5):777-84
references: 14990632
references: Genome Biol. 2006;7 Suppl 1:S12.1-14
references: 16925834
references: Science. 2007 May 18;316(5827):1039-43
references: 17463250
references: PLoS Med. 2005 Mar;2(3):e73
references: 15737014
references: N Engl J Med. 2004 May 20;350(21):2129-39
references: 15118073
references: Lung Cancer. 2010 Mar;67(3):355-60
references: 19473722
references: Pharmacogenet Genomics. 2007 May;17(5):313-9
references: 17429313
references: PLoS Med. 2007 Oct;4(10):1681-89; discussion 1690
references: 17973573
references: Pharmacogenomics. 2008 Aug;9(8):1079-99
references: 18681783
references: Int J Clin Oncol. 2006 Jun;11(3):190-8
references: 16850125
references: Hum Mol Genet. 2011 Jul 15;20(14):2897-904
references: 21531791
references: Lancet Oncol. 2012 Mar;13(3):239-46
references: 22285168
references: Lancet. 2008 Nov 22;372(9652):1809-18
references: 19027483
references: PLoS One. 2013;8(3):e57528
references: 23472089
references: J Thorac Oncol. 2012 Nov;7(11):1640-4
references: 22899358
references: J Clin Oncol. 2011 Jul 20;29(21):2866-74
references: 21670455
references: N Engl J Med. 2006 Feb 9;354(6):567-78
references: 16467544
references: PLoS Med. 2007 Oct;4(10):1669-79; discussion 1680
references: 17973572
references: Exp Cell Res. 2003 Mar 10;284(1):31-53
references: 12648464
references: PLoS Med. 2007 Oct 9;4(10):e294
references: 17927446
references: Mol Cancer Ther. 2009 Dec;8(12):3173-80
references: 19934277