title: Polymorphism in cathelicidin gene (CAMP) that alters Hypoxia-inducible factor (HIF-1α::ARNT) binding is not associated with tuberculosis.
abstract: Polymorphisms in the CAMP gene (cathelicidin) have not been tested in tuberculosis susceptibility. We tested polymorphisms rs9844812 (HIF-1α::ARNT binding site) and rs56122065 (CAMP) plus rs1800972 (DEFB1). SNP rs1800972 was associated with extrapulmonary tuberculosis (EPTB) in a codominant model (genotype CG, P = 0.037, OR 4.82; 95% CI: 0.92-47.42; statistical power, 82%), but not PTB (P = 0.101) in a Mexican population.
authors: In silico Laboratory, Pharmaceutical and Medical Biotechnology Unit, Research Center in Technology and Design Assistance of Jalisco State (CIATEJ, AC), National Council of Science and Technology, Guadalajara, Mexico.
authors: G N
authors: GN
authors: López Campos
authors: J S
authors: JS
authors: Velarde Félix
authors: L
authors: L
authors: Sandoval Ramírez
authors: S
authors: S
authors: Cázares Salazar
authors: A L
authors: AL
authors: Corona Nakamura
authors: G
authors: G
authors: Amaya Tapia
authors: E
authors: E
authors: Prado Montes de Oca
mesh_terms: D020121:5' Untranslated Regions; D000483:Alleles; D000595:Amino Acid Sequence; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000235:genetics*; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D001665:Binding Sites; D016022:Case-Control Studies; D005091:Exons; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D059372:Nucleotide Motifs; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D056510:Position-Specific Scoring Matrices; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D014376:Tuberculosis / Q000235:genetics* / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000378:metabolism; D023083:beta-Defensins / Q000235:genetics; D054804:Cathelicidins
chemical_list: D020121:5' Untranslated Regions; D023181:Antimicrobial Cationic Peptides; C406407:DEFB1 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D023083:beta-Defensins; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D054804:Cathelicidins