title: Role of the aryl hydrocarbon receptor (AhR) in lung inflammation.
abstract: Millions of individuals worldwide are afflicted with acute and chronic respiratory diseases, causing temporary and permanent disabilities and even death. Oftentimes, these diseases occur as a result of altered immune responses. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acts as a regulator of mucosal barrier function and may influence immune responsiveness in the lungs through changes in gene expression, cell-cell adhesion, mucin production, and cytokine expression. This review updates the basic immunobiology of the AhR signaling pathway with regards to inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease, and silicosis following data in rodent models and humans. Finally, we address the therapeutic potential of targeting the AhR in regulating inflammation during acute and chronic respiratory diseases.
authors: Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, Skaggs School of Pharmacy and Allied Health Sciences, The University of Montana, 32 Campus Drive, Skaggs Building Room 284, Missoula, MT, 59812, USA.
authors: Celine A
authors: CA
authors: Beamer
authors: David M
authors: DM
authors: Shepherd
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism*; D008171:Lung Diseases / Q000276:immunology* / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D012829:Silicosis / Q000276:immunology / Q000378:metabolism
chemical_list: D018336:Receptors, Aryl Hydrocarbon
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