title: B-Z transition of (dA-T)(n) duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation.
abstract: The spermine conjugate of the cationic porphyrin ligand (1) selectively induced the B-Z transition of the [(dA-T)n]2 sequence at low salt concentrations. The [(dG-C)n]2 sequence was not transformed into the Z-form. The B-Z transition was induced via an intermediate DNA conformation, which was formed by the external binding and formation of an assembly of 1 onto B-DNA.
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. saski@phar.kyushu-u.ac.jp.
authors: Hideaki
authors: H
authors: Sasaki
authors: Shigeki
authors: S
authors: Sasaki
mesh_terms: D002942:Circular Dichroism; D003124:Colorimetry; D059371:DNA, B-Form / Q000737:chemistry*; D043542:DNA, Z-Form / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011067:Poly dA-dT / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry*; D013096:Spermine / Q000737:chemistry*
chemical_list: D059371:DNA, B-Form; D043542:DNA, Z-Form; D011089:Polydeoxyribonucleotides; D011166:Porphyrins; C016681:poly(dG).poly(dC); D011067:Poly dA-dT; D013096:Spermine