title: TGF-β: an emerging player in drug resistance.
abstract: The transforming growth factor β (TGF-β) pathway acts as a double-edged sword in tumorigenesis. By constraining epithelial cell growth, TGF-β is a potent tumor suppressor. However, TGF-β also acts as a key player in the induction of epithelial-to-mesenchymal transition (EMT), thereby enhancing invasiveness and metastasis. Furthermore, TGF-β signaling has recently been correlated with resistance against both targeted and conventional anticancer agents. Here, we present data demonstrating a role for TGF-β in chemotherapy resistance in colorectal cancer (CRC). We discuss these results in the context of recent findings indicating TGF-β signaling as an emerging player in cancer drug resistance.
authors: Division of Molecular Carcinogenesis; The Netherlands Cancer Institute; Amsterdam, The Netherlands.
authors: Diede
authors: D
authors: Brunen
authors: Stefan M
authors: SM
authors: Willems
authors: Udo
authors: U
authors: Kellner
authors: Rachel
authors: R
authors: Midgley
authors: Iris
authors: I
authors: Simon
authors: René
authors: R
authors: Bernards
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D056892:Mediator Complex / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D051899:Smad2 Protein / Q000378:metabolism; D051900:Smad3 Protein / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; C460107:MED12 protein, human; D056892:Mediator Complex; D034741:RNA, Small Interfering; D051899:Smad2 Protein; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta
keywords: EMT; TGF-β; chemotherapy; drug resistance
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