title: Vulval disease in HIV-positive women attending a tertiary vulval dermatology clinic over a five-year period.
abstract: There is a paucity of data on vulval disease in HIV-infected women. We describe the spectrum of vulval disease in HIV-infected women attending a tertiary vulval dermatology referral centre over a five-year period. Seven vulval conditions were identified in 14 women. Most were attending for HIV care (n = 12, 86%), and on combined antiretroviral therapy (CART) with a CD4 cell count above 200 cells/µL (n = 9, 64%) at diagnosis. Imiquimod therapy was effective in treating undifferentiated vulval intraepithelial neoplasia (uVIN) - the most common diagnosis. There were no cases of invasive vulval carcinoma. Hypertrophic herpes simplex virus occurred in one woman stable on CART with good immune reconstitution. Clinicians should be vigilant about the spectrum of vulval disease in HIV-infected women and consider genital examination as part of routine care.
authors: Department of GUM/HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors: Olamide
authors: O
authors: Dosekun
authors: Pippa
authors: P
authors: Farrugia
authors: Fiona
authors: F
authors: Lewis
authors: Gulshan
authors: G
authors: Sethi
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000628:therapy; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D000077271:Imiquimod; D008875:Middle Aged; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014845:Vulvar Diseases / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: AIDS; HIV; VIN; Women; dermatosis; herpes simplex virus; human immunodeficiency virus; human papillomavirus