title: Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold.
abstract: A novel multicatalytic MBH-Michael tandem reaction has been developed for the asymmetric assembly of ninhydrin, nitroolefins and aldehydes into a structurally complex oxa-spirocyclic indanone backbone. Successive iodocyclization allowed us to convert these multifunctional allylic products into fused chiral natural product mimics.
authors: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China. hanbo@cdutcm.edu.cn pengchengchengdu@126.com.
authors: Xiang
authors: X
authors: Li
authors: Lei
authors: L
authors: Yang
authors: Cheng
authors: C
authors: Peng
authors: Xin
authors: X
authors: Xie
authors: Hai-Jun
authors: HJ
authors: Leng
authors: Biao
authors: B
authors: Wang
authors: Zheng-Wei
authors: ZW
authors: Tang
authors: Gu
authors: G
authors: He
authors: Liang
authors: L
authors: Ouyang
authors: Wei
authors: W
authors: Huang
authors: Bo
authors: B
authors: Han
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D009555:Ninhydrin / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D007189:Indans; C013352:indacrinone; D009555:Ninhydrin