title: Biology and host response to Cyprinid herpesvirus 3 infection in common carp.
abstract: Viruses from the family Alloherpesviridae form an aquatic clade of herpesviruses infecting fish and amphibia. Diseases caused by these herpesviruses are of increasing importance because of the high morbidity and mortality associated with the infection, and the difficulties in diagnosing latently infected carriers. Cyprinid herpesvirus 3 (CyHV-3) induces a severe disease and mortality in common carp and thus greatly affects carp aquaculture and trade. This review summarises advancements in the understanding of the infection process and the current knowledge on immune responses of carp to CyHV-3. A focus is laid on host genetics and immunity responsible for resistance/survival from the disease and on the viral mechanisms accountable for evasion of carp immune responses. As current knowledge of immune responses to CyHV-3 is still limited, perspectives for future studies are outlined. Analysing CyHV-3 fish-host interactions will be useful and thought-provoking for a basic understanding of fish immune responses.
authors: Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
authors: Mikołaj
authors: M
authors: Adamek
authors: Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. Electronic address: Dieter.Steinhagen@tiho-hannover.de.
authors: Dieter
authors: D
authors: Steinhagen
authors: Polish Academy of Sciences, Institute of Ichthyobiology and Aquaculture in Gołysz, Kalinowa 2, 43-520 Chybie, Poland.
authors: Ilgiz
authors: I
authors: Irnazarow
authors: Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, 900 Gajwa-dong, Jinju, Gyeongnam 660-710, South Korea.
authors: Jun-ichi
authors: J
authors: Hikima
authors: Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, 900 Gajwa-dong, Jinju, Gyeongnam 660-710, South Korea.
authors: Tae-Sung
authors: TS
authors: Jung
authors: Aquatic Biotechnology Center of WCU Project, College of Veterinary Medicine, Gyeongsang National University, 900 Gajwa-dong, Jinju, Gyeongnam 660-710, South Korea; Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513, Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan.
authors: Takashi
authors: T
authors: Aoki
mesh_terms: D000818:Animals; D003530:Cyprinidae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007109:Immunity / Q000235:genetics; D018140:Varicellovirus / Q000276:immunology*
keywords: Common carp; Cyprinid herpesvirus 3; Immune evasion; Immune response; Immunogenetics