title: Impact of mTOR-I on fertility and pregnancy: state of the art and review of the literature.
abstract: Successful transplantation should lead to improvements in sexual function and sex hormone disturbances in both men and women, but immunosuppressive drugs may interfere with hormone metabolism. In this regard, several studies have showed a potential negative effect of mTOR inhibitors (mTORi) on male gonadal function, while their role in the female patients is not well documented in the literature. Successful pregnancy is possible after solid organ transplantation. The fetal effects of mTORi are still poorly defined but they seem not to represent an absolute contraindication for pregnancy. The aim of our study would be to review the impact of mTORi on fertility and pregnancy in order to have a clearer picture about their possible use after organ transplantation.
authors: Department of Gynecological-Obstetrical and Urological Sciences, University of Rome Sapienza, Italy.
authors: Marialuisa
authors: M
authors: Framarino-dei-Malatesta
authors: Martina
authors: M
authors: Derme
authors: Tommaso M
authors: TM
authors: Manzia
authors: Giuseppe
authors: G
authors: Iaria
authors: Linda
authors: L
authors: De Luca
authors: Laura
authors: L
authors: Fazzolari
authors: Angela
authors: A
authors: Napoli
authors: Pasquale
authors: P
authors: Berloco
authors: Timil
authors: T
authors: Patel
authors: Giuseppe
authors: G
authors: Orlando
authors: Giuseppe
authors: G
authors: Tisone
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000276:immunology; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000276:immunology / Q000517:prevention & control*; D011247:Pregnancy / Q000187:drug effects / Q000276:immunology; D011248:Pregnancy Complications / Q000276:immunology / Q000517:prevention & control*; D011788:Quality of Life; D020123:Sirolimus / Q000494:pharmacology* / Q000627:therapeutic use; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D007166:Immunosuppressive Agents; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus