title: Sphingolipid metabolic pathway: an overview of major roles played in human diseases.
abstract: Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Given that most of these cellular processes form the basis for several pathologies, it is not surprising that sphingolipids are key players in several pathological processes. This review discusses the role of the sphingolipid metabolic pathway in diabetes, Alzheimer's disease, and hepatocellular carcinoma, with a special emphasis on the changes in gene expression pattern in these disease conditions. For convenience, the sphingolipid metabolic pathway is divided into hypothetical compartments (modules) with each compartment representing a physiological process and changes in gene expression pattern are mapped to each of these modules. It appears that alterations in the gene expression pattern in these disease conditions are biased to manipulate the system in order to result in a particular disease.
authors: Biology Group, Connexios Life Sciences Private Limited, No.49 Shilpa Vidya, First Main Road, 3rd Phase JP Nagara, Bangalore 560078, India.
authors: Raghavendra
authors: R
authors: Pralhada Rao
authors: Nanditha
authors: N
authors: Vaidyanathan
authors: Mathiyazhagan
authors: M
authors: Rengasamy
authors: Anup
authors: A
authors: Mammen Oommen
authors: Neeti
authors: N
authors: Somaiya
authors: M R
authors: MR
authors: Jagannath
references: J Neuroinflammation. 2009 Dec 26;6:41
references: 20035627
references: Diabetes. 2004 May;53(5):1215-21
references: 15111489
references: Diabetes. 2006 Sep;55(9):2579-87
references: 16936207
references: Trends Mol Med. 2007 Aug;13(8):327-36
references: 17588815
references: Science. 2004 Oct 15;306(5695):457-61
references: 15486293
references: Biochim Biophys Acta. 2009 Jul;1791(7):684-91
references: 19416656
references: J Neurosci. 2010 Sep 22;30(38):12676-89
references: 20861373
references: Biochim Biophys Acta. 2006 Dec;1758(12):2057-79
references: 16854371
references: Cell. 1994 Sep 23;78(6):1005-15
references: 7923351
references: Nature. 2005 Jan 27;433(7024):425-30
references: 15674294
references: Glycoconj J. 2004;21(6):295-304
references: 15514478
references: J Clin Invest. 2011 Nov;121(11):4222-30
references: 22045572
references: Neuromolecular Med. 2010 Dec;12(4):331-40
references: 20571935
references: Am J Pathol. 2009 Apr;174(4):1241-51
references: 19264902
references: Curr Biol. 2004 Feb 17;14(4):R163-5
references: 15027471
references: J Biol Chem. 2003 May 30;278(22):19777-83
references: 12649271
references: Cold Spring Harb Perspect Biol. 2011 Jun 01;3(6):
references: 21502308
references: Nat Rev Neurosci. 2007 Jul;8(7):499-509
references: 17551515
references: Oxid Med Cell Longev. 2012;2012:479348
references: 22577490
references: Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30
references: 12782147
references: Prog Lipid Res. 2006 Jan;45(1):42-72
references: 16445986
references: Annu Rev Cell Dev Biol. 2005;21:81-103
references: 16212488
references: Ann Neurol. 2002 Oct;52(4):448-57
references: 12325074
references: J Neurosci Res. 2008 Jul;86(9):2091-9
references: 18335524
references: J Clin Invest. 2002 Jul;110(1):3-8
references: 12093880
references: Mol Cell Biol. 2003 Nov;23(21):7794-808
references: 14560023
references: Trends Biochem Sci. 2007 Oct;32(10):457-68
references: 17928229
references: Diabetes. 2004 Jan;53(1):25-31
references: 14693694
references: Biochim Biophys Acta. 2010 Aug;1801(8):878-86
references: 20452460
references: J Lipids. 2011;2011:565316
references: 21490804
references: Neurochem Res. 2000 Oct;25(9-10):1161-72
references: 11059790
references: Int J Cancer. 2001 Oct 15;94(2):157-65
references: 11668492
references: Neurochem Res. 2007 Apr-May;32(4-5):845-56
references: 17342407
references: Eur J Neurosci. 2004 Dec;20(12):3489-97
references: 15610181
references: J Biol Chem. 2003 Jan 31;278(5):2896-902
references: 12417588
references: Curr Drug Targets Infect Disord. 2004 Dec;4(4):311-22
references: 15578972
references: Cancer Biol Ther. 2011 Jan 15;11(2):138-49
references: 21209555
references: J Biol Chem. 1999 Aug 20;274(34):24202-10
references: 10446195
references: Neuromolecular Med. 2010 Dec;12(4):306-19
references: 20680704
references: J Alzheimers Dis. 2010;19(1):311-23
references: 20061647
references: Mol Cell Biol. 1998 Sep;18(9):5457-64
references: 9710629
references: Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50
references: 18216770
references: J Biol Chem. 2003 Mar 21;278(12):10297-303
references: 12525490
references: Endocr Metab Immune Disord Drug Targets. 2011 Dec;11(4):262-72
references: 21696364
references: Diabetologia. 2009 Dec;52(12):2612-5
references: 19669729
references: Cell. 2005 Feb 25;120(4):545-55
references: 15734686
references: Biochem J. 2004 Sep 1;382(Pt 2):619-29
references: 15193147
references: Endocrinology. 1994 Jan;134(1):264-70
references: 8275942
references: J Biol Chem. 2003 Oct 3;278(40):38206-13
references: 12855693
references: Biochim Biophys Acta. 2006 Aug;1761(8):927-46
references: 16901751
references: Science. 1993 Jan 1;259(5091):87-91
references: 7678183
references: J Biol Chem. 2002 Jul 19;277(29):25847-50
references: 12011103
references: FEBS Lett. 2012 May 7;586(9):1300-5
references: 22465662
references: Nat Rev Cancer. 2004 Aug;4(8):604-16
references: 15286740
references: Am J Med Sci. 1978 Nov-Dec;276(3):293-303
references: 742637
references: J Neurosci. 2011 Feb 2;31(5):1837-49
references: 21289194
references: Cell Mol Life Sci. 2005 Jan;62(2):128-42
references: 15666085
references: Physiol Rev. 2001 Apr;81(2):741-66
references: 11274343
references: Eur J Neurosci. 2007 Oct;26(8):2131-41
references: 17908174
references: Clin Cancer Res. 2003 Jan;9(1):415-23
references: 12538495
references: Cell Mol Life Sci. 2001 Dec;58(14):2053-68
references: 11814056
references: J Clin Invest. 2006 Jul;116(7):1793-801
references: 16823477
references: Adv Exp Med Biol. 2010;688:185-205
references: 20919655
references: Diabetologia. 2009 Dec;52(12):2475-7
references: 19802602
references: J Cell Biol. 2009 Jan 12;184(1):143-58
references: 19139267
references: J Biol Chem. 1990 Oct 5;265(28):16880-5
references: 2211599
references: Science. 1992 Mar 27;255(5052):1715-8
references: 1313189
references: Nat Rev Immunol. 2011 Feb;11(2):98-107
references: 21233852
references: Cell Signal. 2002 Mar;14(3):231-8
references: 11812651
references: Int J Alzheimers Dis. 2011;2011:695413
references: 21660213
references: Pharmacol Res. 2003 May;47(5):373-81
references: 12676511
references: J Biol Chem. 2005 Jul 29;280(30):28110-7
references: 15923191
references: Ann Neurol. 2004 Feb;55(2):257-67
references: 14755730
references: Cancer Res. 2001 Feb 1;61(3):1233-40
references: 11221856
references: Adv Exp Med Biol. 2011;721:1-17
references: 21910079
references: Cell Death Differ. 2006 Mar;13(3):385-92
references: 16397584
references: J Biol Chem. 1996 Aug 9;271(32):19530-6
references: 8702646
references: J Biol Chem. 1997 Jan 10;272(2):971-6
references: 8995390
references: Physiol Rev. 2001 Oct;81(4):1689-723
references: 11581500
references: J Lipid Res. 2007 Dec;48(12):2701-8
references: 17890681
references: Annu Rev Med. 2002;53:615-27
references: 11818492
references: J Chem Neuroanat. 2004 Sep;28(1-2):67-78
references: 15363492
references: Adv Exp Med Biol. 2010;688:118-30
references: 20919650
references: Nutr Rev. 2007 Jun;65(6 Pt 2):S39-46
references: 17605313
references: Prostaglandins Other Lipid Mediat. 2008 Feb;85(1-2):1-16
references: 18035569
references: Neurobiol Aging. 2010 Mar;31(3):398-408
references: 18547682
references: Anticancer Agents Med Chem. 2012 May;12(4):364-75
references: 22043999
references: J Neurochem. 1997 Oct;69(4):1612-21
references: 9326290