title: Carboxymethyl functionalization of amylopectin and its evaluation as a nanometric drug carrier.
abstract: Carboxymethylation of amylopectin was accomplished by reacting it with monochloroacetic acid. The results of characterization study confirmed the carboxymethyl functionalization with degree of substitution of 1.25. Carboxymethyl amylopectin was found to be slightly more crystalline, appearing morphologically as polyhedral flakes with striated surface. Further, carboxymethylation of amylopectin modified its compression characteristic from fragmentary to plastic. Interaction of carboxymethyl amylopectin (0.001-0.005%, w/v) with chitosan (0.05-0.075% w/v) using ibuprofen (0.05%, w/v) as a model drug provided polyelectrolyte nanoparticles of size 182.7-353.3 nm and 75-92% drug entrapment. The polyelectrolyte nanoparticles showed a sustained release of drug following zero-order kinetics with mechanism of release being combination of matrix erosion and diffusion through the matrix.
authors: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India.
authors: Kanika
authors: K
authors: Thakur
authors: Munish
authors: M
authors: Ahuja
authors: Ashok
authors: A
authors: Kumar
mesh_terms: D000687:Amylopectin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D008745:Methylation; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D048271:Chitosan; D000687:Amylopectin; D007052:Ibuprofen
keywords: Amylopectin; Chitosan; Ibuprofen; Polyelectrolyte nanoparticles