title: Genomics of pain in osteoarthritis.
abstract: Osteoarthritis (OA) accounts for the majority of the disease burden for musculoskeletal disorders and is one of the leading causes of disability worldwide. This disability is the result not of the cartilage loss that defines OA radiographically, but of the chronic pain whose presence defines symptomatic OA. It is becoming clear that many genes, each with a small effect size, contribute to the risk of developing OA. However, the genetics of OA pain are only just starting to be explored. This review will describe the first genes to have been identified in genomic studies of OA pain, as well as the possible dual roles of genes previously identified in genomic studies of OA in the context of pain. Difficulties associated with attempting to characterise the genetics of OA pain will be discussed and promising future avenues of research into genetic and epigenetic factors affecting OA pain described.
authors: Neurorestoration Group, Wolfson CARD, School of Biomedical Sciences, Kings College London Guy's Campus, London SE1 1UL, UK. thakurmatthew@gmail.com
authors: M
authors: M
authors: Thakur
authors: J M
authors: JM
authors: Dawes
authors: S B
authors: SB
authors: McMahon
mesh_terms: D018771:Arthralgia / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D023281:Genomics; D006801:Humans; D010003:Osteoarthritis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors
keywords: GWAS; Genetics; Genomics; Nociception; Osteoarthritis; Pain; Symptomatic
references: Pain. 2012 Jul;153(7):1525-1536
references: 22633683
references: Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4536-41
references: 15764707
references: Neuroscience. 2009 Mar 17;159(2):780-6
references: 19167466
references: Rheumatology (Oxford). 2010 Sep;49(9):1753-5
references: 20525736
references: J Int Med Res. 2011;39(1):1-9
references: 21672302
references: Arthritis Rheum. 2011 Mar;63(3):810-8
references: 21305503
references: Osteoarthritis Cartilage. 2008 Feb;16(2):137-62
references: 18279766
references: BMC Musculoskelet Disord. 2012 Feb 20;13:23
references: 22348792
references: Arthritis Rheum. 2010 May;62(5):1308-18
references: 20213802
references: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23
references: 22566624
references: J Neurosci. 2010 Aug 11;30(32):10860-71
references: 20702715
references: Neuroscience. 1996 Apr;71(4):1091-4
references: 8684613
references: PLoS One. 2012;7(3):e33730
references: 22470467
references: Arthritis Rheum. 2009 Feb;60(2):628-9
references: 19180497
references: Pain. 2004 Jun;109(3):488-496
references: 15157710
references: Pain. 2003 Aug;104(3):471-480
references: 12927619
references: Br J Pharmacol. 1991 Nov;104(3):765-7
references: 1797337
references: Brain Res. 2006 Oct 20;1116(1):206-14
references: 16938273
references: Purinergic Signal. 2009 Jun;5(2):257-62
references: 19319666
references: J Rheumatol. 1997 Jul;24(7):1384-9
references: 9228141
references: J Neurosci Res. 2005 Oct 1;82(1):51-62
references: 16047385
references: Osteoarthritis Cartilage. 2007 Oct;15(10):1190-8
references: 17500014
references: PLoS One. 2009 Jun 23;4(6):e6016
references: 19547755
references: Pain. 2007 Sep;131(1-2):8-20
references: 17257750
references: Ann Rheum Dis. 2010 May;69(5):856-61
references: 19934104
references: Pain. 2002 Mar;96(1-2):89-97
references: 11932065
references: Ann Neurol. 2012 Jan;71(1):26-39
references: 21698661
references: J Leukoc Biol. 2006 May;79(5):1022-32
references: 16522746
references: J Neurosci. 2011 Apr 13;31(15):5865-75
references: 21490228
references: Nat Med. 2012 Mar 25;18(4):595-9
references: 22447075
references: Ann N Y Acad Sci. 2008 Nov;1144:42-52
references: 19076362
references: J Pain. 2011 Nov;12(11 Suppl):T61-74
references: 22074753
references: Osteoarthritis Cartilage. 2012 May;20(5):339-349
references: 22281264
references: Gastroenterology. 2008 Jun;134(7):2059-69
references: 18343379
references: Ann Rheum Dis. 2013 Mar;72(3):427-36
references: 22956598
references: Brain Res. 2002 Mar 15;930(1-2):150-62
references: 11879805
references: Mol Med. 2005 Jan-Dec;11(1-12):1-15
references: 16557334
references: Eur J Pain. 2009 Mar;13(3):263-72
references: 18554968
references: Curr Opin Rheumatol. 2010 Mar;22(2):139-43
references: 20090528
references: Am J Hum Genet. 2011 Sep 9;89(3):446-50
references: 21871595
references: Pain. 2010 Jun;149(3):573-581
references: 20418016
references: Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):840-53
references: 20833281
references: Ann Rheum Dis. 2011 Sep;70(9):1556-61
references: 21616913
references: Pain Med. 2012 Apr;13(4):522-40
references: 22390201
references: BMC Musculoskelet Disord. 2008 Sep 02;9:116
references: 18764949
references: Sci Transl Med. 2011 Jul 6;3(90):90ra60
references: 21734176
references: Blood. 2009 Oct 8;114(15):3244-54
references: 19567879
references: Eur J Pharmacol. 2010 Sep 1;641(2-3):108-13
references: 20538089
references: Arthritis Res Ther. 2009;11(3):R82
references: 19490633
references: J Neurosci. 2010 Feb 10;30(6):2138-49
references: 20147541
references: Curr Pain Headache Rep. 2011 Jun;15(3):185-92
references: 21327569
references: J Neurosci. 1998 Jul 15;18(14):5456-62
references: 9651226
references: Lancet. 2012 Sep 1;380(9844):815-23
references: 22763110
references: PLoS One. 2012;7(10):e48135
references: 23110189
references: Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3731-6
references: 21245297
references: Arthritis Rheum. 2002 May;46(5):1223-7
references: 12115227
references: Mol Pharmacol. 2009 May;75(5):1014-20
references: 19255242
references: Pain. 2007 Mar;128(1-2):136-47
references: 17070997
references: Arthritis Care Res. 1995 Sep;8(3):182-8
references: 7654803
references: Rheumatology (Oxford). 2010 Oct;49(10):1852-61
references: 20581375
references: Mol Pain. 2007 Oct 29;3:31
references: 17967183
references: J Pain. 2011 Nov;12(11 Suppl):T27-45
references: 22074750
references: Purinergic Signal. 2007 Mar;3(1-2):163-9
references: 18404430
references: Arthritis Rheum. 2009 Apr;60(4):1035-41
references: 19333945
references: Neuropsychopharmacology. 2008 Mar;33(4):924-32
references: 17522626
references: Nat Genet. 2011 Oct 02;43(11):1142-6
references: 21964574
references: J Urol. 2009 Mar;181(3):980-4
references: 19150095
references: Arch Biochem Biophys. 2008 Oct 1;478(1):43-51
references: 18671934
references: Osteoarthritis Cartilage. 2011 Mar;19(3):265-71
references: 21146623
references: Pain. 2011 Mar;152(3):566-572
references: 21239114
references: Gene. 2011 Jul 1;480(1-2):34-41
references: 21397669
references: Trends Mol Med. 2005 Apr;11(4):186-91
references: 15823757
references: Arthritis Rheum. 2011 Mar;63(3):691-9
references: 21360498
references: Arthritis Care Res (Hoboken). 2012 Feb;64(2):248-55
references: 22012846
references: Curr Opin Rheumatol. 2009 Sep;21(5):507-12
references: 19633560
references: J Thromb Haemost. 2003 Jul;1(7):1391-7
references: 12871272
references: Neuron. 2012 Feb 9;73(3):435-44
references: 22325197
references: Clin Pharmacol Ther. 2009 Jan;85(1):25-30
references: 18548001
references: PLoS One. 2012;7(7):e40779
references: 22815815
references: Eur J Pain. 2009 Sep;13(8):786-93
references: 18955000
references: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5198-203
references: 15758069
references: Pain. 2008 May;136(1-2):53-61
references: 17686583
references: Psychopharmacology (Berl). 2004 Nov;176(3-4):343-52
references: 15197532
references: Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5148-53
references: 20212137
references: Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15753-7
references: 9861042
references: Ann Rheum Dis. 2012 Jun;71(6):1042-8
references: 22440827
references: Mol Pain. 2012 Jun 19;8:47
references: 22713358
references: Pain. 2011 Feb;152(2):300-307
references: 21130573
references: Pharmacol Rev. 2012 Oct;64(4):939-71
references: 23023032
references: Brain Behav Immun. 2010 Mar;24(3):474-85
references: 20006700
references: N Engl J Med. 2010 Oct 14;363(16):1521-31
references: 20942668
references: Pain. 2006 Dec 5;125(3):216-224
references: 16837133
references: Osteoarthritis Cartilage. 2010 Apr;18(4):581-92
references: 20060954
references: Psychopharmacology (Berl). 2008 Mar;197(1):115-26
references: 18060387
references: Arthritis Rheum. 2010 Feb;62(2):499-510
references: 20112360
references: Arthritis Care Res (Hoboken). 2011 Mar;63(3):440-4
references: 21031562
references: Brain Res. 2008 Jul 11;1219:59-65
references: 18538749
references: J Neuroimmune Pharmacol. 2012 Dec;7(4):904-13
references: 22547300
references: Ann Rheum Dis. 2012 Jun;71(6):1073-80
references: 22294637
references: Neurosci Lett. 2011 Jul 20;499(2):109-13
references: 21640790
references: Osteoarthritis Cartilage. 2011 Mar;19(3):254-64
references: 21059398
references: Joint Bone Spine. 2012 May;79(3):298-303
references: 21727020
references: Neuroscience. 2005;131(2):491-8
references: 15708490
references: Arthritis Rheum. 2011 Jul;63(7):1908-17
references: 21717421
references: Mol Cell Biochem. 2009 Jan;321(1-2):135-43
references: 18836817
references: J Pain. 2011 Nov;12(11 Suppl):T92-101
references: 22074755
references: Psychopharmacology (Berl). 2005 Jun;180(1):1-11
references: 15830230
references: BMJ. 2009 Aug 21;339:b2844
references: 19700505
references: J Neuroinflammation. 2012 May 30;9:111
references: 22647544
references: Arthritis Rheum. 2006 Nov;54(11):3494-507
references: 17075851
references: Arthritis Rheum. 2009 Sep 15;61(9):1226-34
references: 19714588
references: Ann Neurol. 2009 Jun;65(6):733-41
references: 19557861
references: Ann N Y Acad Sci. 2010 Apr;1193:60-9
references: 20398009
references: Spine J. 2010 Nov;10(11):958-60
references: 20970736