title: Predictive value of XPD polymorphisms on platinum-based chemotherapy in non-small cell lung cancer: a systematic review and meta-analysis.
abstract: BACKGROUND
  The correlation between xeroderma pigmentosum group D (XPD) polymorphisms (Lys751Gln and Asp312Asn) and clinical outcomes of non-small cell lung cancer (NSCLC) patients, who received platinum-based chemotherapy (Pt-chemotherapy), is still inconclusive. This meta-analysis was aimed to systematically review published evidence and ascertain the exact role of XPD polymorphisms.
  
  
  METHODS
  Databases of MEDLINE and EMBASE were searched up to April 2013 to identify eligible studies. A rigorous quality assessment of eligible studies was conducted according the Newcastle-Ottawa Quality Assessment Scales. The relationship between XPD polymorphisms and response to Pt-chemotherapy and survival was analyzed.
  
  
  RESULTS
  A total of 22 eligible studies were included and analyzed in this meta-analysis. The overall analysis suggested that the XPD Lys751Gln polymorphism was not associated with response to Pt-chemotherapy or survival. However, the XPD 312Asn allele was significantly associated with poor response to Pt-chemotherapy compared with the Asp312 allele (Asn vs. Asp: OR = 0.435, 95% CI: 0.261-0.726). Additionally, the variant genotype of XPD Asp312Asn polymorphism was associated with favorable survival in Caucasian (AspAsn vs. AspAsp: HR = 0.781, 95% CI: 0.619-0.986) but unfavorable survival in Asian (AspAsn+AsnAsn vs. AspAsp: HR = 1.550, 95% CI: 1.038-2.315).
  
  
  CONCLUSIONS
  These results suggest that XPD Asp312Asn polymorphism may function as a predictive biomarker on platinum-based chemotherapy in NSCLC and further studies are warranted.
authors: Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Institute of Jiangsu Province, Nanjing, China.
authors: Mantang
authors: M
authors: Qiu
authors: Xin
authors: X
authors: Yang
authors: Jingwen
authors: J
authors: Hu
authors: Xiangxiang
authors: X
authors: Ding
authors: Feng
authors: F
authors: Jiang
authors: Rong
authors: R
authors: Yin
authors: Lin
authors: L
authors: Xu
mesh_terms: D000483:Alleles; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D044466:Asian People; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D017671:Platinum Compounds / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D044465:White People; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human
references: J Thorac Oncol. 2011 Nov;6(11):1793-800
references: 21841506
references: PLoS Med. 2009 Jul 21;6(7):e1000097
references: 19621072
references: Ann Oncol. 2004 Aug;15(8):1194-203
references: 15277258
references: Cancer Treat Rev. 1998 Oct;24(5):331-44
references: 9861196
references: Environ Health Perspect. 2003 Nov;111(15):1843-50
references: 14630517
references: Clin Cancer Res. 2012 Jul 15;18(14):3972-81
references: 22705987
references: Clin Transl Oncol. 2012 Mar;14(3):207-13
references: 22374424
references: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16
references: 10655437
references: Cancer Chemother Pharmacol. 2012 Dec;70(6):883-90
references: 23053267
references: Lung Cancer. 2011 Jul;73(1):110-5
references: 21129812
references: Lung Cancer. 2012 Oct;78(1):92-9
references: 22889494
references: Cancer. 2011 Nov 15;117(22):5172-81
references: 21523769
references: Lung Cancer. 2011 Feb;71(2):191-8
references: 20627363
references: Ann Intern Med. 1997 Nov 1;127(9):820-6
references: 9382404
references: J Clin Oncol. 2009 Jul 20;27(21):3540-6
references: 19470925
references: J Natl Cancer Inst. 2002 Jul 17;94(14):1091-9
references: 12122100
references: PLoS One. 2012;7(6):e38150
references: 22761669
references: Carcinogenesis. 2000 Mar;21(3):453-60
references: 10688865
references: Med Oncol. 2011 Mar;28(1):315-21
references: 20143185
references: Lung Cancer. 2012 Jan;75(1):102-9
references: 21676483
references: Ann Oncol. 2006 Apr;17(4):668-75
references: 16407418
references: Br J Cancer. 2001 May 4;84(9):1143-5
references: 11336462
references: Int J Cancer. 1999 Mar 15;80(6):827-41
references: 10074914
references: Cancer Res. 2002 Oct 1;62(19):5457-62
references: 12359753
references: PLoS One. 2013 Apr 30;8(4):e62485
references: 23653681
references: Cancer. 2012 May 1;118(9):2466-75
references: 22031394
references: Clin Lung Cancer. 2009 Mar;10(2):118-23
references: 19362955
references: Am J Clin Oncol. 2010 Oct;33(5):489-94
references: 20351547
references: Lung Cancer. 2004 Jun;44(3):311-6
references: 15140544
references: J Thorac Oncol. 2011 Dec;6(12):2018-26
references: 22052224
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: Lung Cancer. 2011 Jun;72(3):370-7
references: 21075476
references: PLoS One. 2012;7(3):e33200
references: 22479369
references: Zhonghua Zhong Liu Za Zhi. 2006 Mar;28(3):196-9
references: 16875604
references: CA Cancer J Clin. 2002 Jan-Feb;52(1):23-47
references: 11814064
references: Med Oncol. 2012 Sep;29(3):1622-8
references: 21805378
references: J Thorac Oncol. 2012 Jun;7(6):973-81
references: 22551904
references: Clin Cancer Res. 1998 May;4(5):1087-100
references: 9607565
references: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references: 20610543
references: Clin Cancer Res. 2008 Mar 15;14(6):1797-803
references: 18347182
references: Mol Carcinog. 2013 Dec;52(12):923-31
references: 22821704
references: J Clin Oncol. 2004 Jul 1;22(13):2594-601
references: 15173214
references: Asian Pac J Cancer Prev. 2012;13(6):2583-6
references: 22938424
references: J Natl Compr Canc Netw. 2006 Jul;4(6):548-82
references: 16813724
references: BMJ. 1995 Oct 7;311(7010):899-909
references: 7580546
references: J Clin Oncol. 2004 Jan 15;22(2):330-53
references: 14691125
references: Asian Pac J Cancer Prev. 2009;10(5):859-64
references: 20104979