title: Doxorubicin-antioxidant co-drugs.
abstract: Doxorubicin-antioxidant multitarget compounds 6 and 7 were obtained by combining doxorubicin (DOX) with caffeic and ferulic acids through an ester linkage at C-14. The products were studied in in vitro models of cardiomyocytes and breast cancer cells, characterized by different degrees of resistance to DOX, due to different expressions of ATP binding cassette (ABC) transporters. Compound 7 was found to be less toxic than DOX in cardiomyocytes and to display the same possibly higher toxicity against the resistant breast cancer cells. This result shows that appropriate DOX-antioxidant co-drugs can limit the onset of cardiac damage, a significant side-effect of DOX, without impairing the antitumor activity of the parent antibiotic.
authors: Department of Science and Drug Technology, University of Torino, Torino, Italy.
authors: Konstantin
authors: K
authors: Chegaev
authors: Chiara
authors: C
authors: Riganti
authors: Barbara
authors: B
authors: Rolando
authors: Loretta
authors: L
authors: Lazzarato
authors: Elena
authors: E
authors: Gazzano
authors: Stefano
authors: S
authors: Guglielmo
authors: Dario
authors: D
authors: Ghigo
authors: Roberta
authors: R
authors: Fruttero
authors: Alberto
authors: A
authors: Gasco
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects
chemical_list: D000975:Antioxidants; D004317:Doxorubicin
keywords: ABC transporters; Antioxidant; Cardiotoxicity; Doxorubicin; Ferulic acid