title: Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.
abstract: Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10(-14)) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.
authors: Infections and Immunoepidemiology Branch.
authors: Peter V
authors: PV
authors: Aka
authors: Mark H
authors: MH
authors: Kuniholm
authors: Ruth M
authors: RM
authors: Pfeiffer
authors: Alan S
authors: AS
authors: Wang
authors: Wei
authors: W
authors: Tang
authors: Sabrina
authors: S
authors: Chen
authors: Jacquie
authors: J
authors: Astemborski
authors: Michael
authors: M
authors: Plankey
authors: Maria C
authors: MC
authors: Villacres
authors: Marion G
authors: MG
authors: Peters
authors: Seema
authors: S
authors: Desai
authors: Eric C
authors: EC
authors: Seaberg
authors: Brian R
authors: BR
authors: Edlin
authors: Howard D
authors: HD
authors: Strickler
authors: David L
authors: DL
authors: Thomas
authors: Ludmila
authors: L
authors: Prokunina-Olsson
authors: Gerald B
authors: GB
authors: Sharp
authors: Thomas R
authors: TR
authors: O'Brien
mesh_terms: D000328:Adult; D001741:Black or African American; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D016174:Hepacivirus / Q000276:immunology* / Q000302:isolation & purification*; D006526:Hepatitis C / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D011446:Prospective Studies; D000095022:Interferon Lambda
chemical_list: D007378:Interleukins; C579163:IFNL4 protein, human; D000095022:Interferon Lambda
keywords: HCV; IFNL4; IL28B; genetic; viral clearance
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