title: Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period.
abstract: Prolonged early-life seizures are associated with disruptions of affective and cognitive function. Postictal disturbances, temporary functional deficits that persist for hours to days after seizures, have not yet been thoroughly characterized. Here, we used kainic acid (KA) to induce status epilepticus (SE) in immature rats at three developmental stages (postnatal day (P) 15, 21, or 30) and subsequently assessed spatial learning and memory in a Barnes maze, exploratory behavior in an open field, and the spatiotemporal distribution of cell injury during the first 7-10 days of the postictal period. At 1 day post-SE, P15-SE rats showed no deficit in the Barnes maze but were hyperexploratory in an open field compared with their littermate controls. In contrast, P21- and P30-SE rats exhibited markedly impaired performance in the Barnes maze and exhibited significantly reduced open field exploration suggestive of anxiety-like behavior. These behavioral changes were transient in P15 rats but more persistent in P21 and enduring in P30 rats after KA-SE. The time course of behavioral deficits in P21 and P30 rats was temporally correlated with the presence of neuronal injury in the lateral septal nuclei, amygdala, and ventral subiculum/CA1, regions involved in modulation of the hypothalamic-pituitary-adrenal stress response.
authors: Neurobiology Program, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA.
authors: Lauren M
authors: LM
authors: Mlsna
authors: Sookyong
authors: S
authors: Koh
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology*; D053938:DNA Fragmentation / Q000187:drug effects; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid / Q000633:toxicity; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D001523:Mental Disorders / Q000209:etiology*; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D045442:Rotarod Performance Test; D012640:Seizures / Q000139:chemically induced / Q000150:complications* / Q000473:pathology*
chemical_list: D007608:Kainic Acid
keywords: Amygdala; Anxiety; BLA; Cell death; Epilepsy; HPA; ISEL; Immature brain; KA; LS; P; PBS; Postictal state; SE; Seizure; basolateral amygdala; hypothalamic–pituitary–adrenal; in situ end labeling; kainic acid; lateral septum; phosphate buffered saline; postnatal; status epilepticus; vSub/CA1; ventral subiculum/cornu ammonis 1
references: Semin Pediatr Neurol. 2005 Dec;12(4):222-8
references: 16780293
references: Behav Brain Res. 1996 Nov;81(1-2):43-52
references: 8950000
references: Dev Psychopathol. 2001 Summer;13(3):419-49
references: 11523842
references: Dev Psychobiol. 2003 Dec;43(4):373-83
references: 15027421
references: Epilepsy Behav. 2005 Sep;7(2):222-30
references: 15996529
references: Epilepsy Res. 1994 Dec;19(3):191-204
references: 7698095
references: Pediatr Neurol. 2002 Feb;26(2):125-9
references: 11897476
references: Physiol Behav. 1992 Nov;52(5):945-51
references: 1484851
references: Learn Mem. 2006 Nov-Dec;13(6):809-19
references: 17101874
references: Cell. 1995 Jun 16;81(6):905-15
references: 7781067
references: J Neurosurg. 2003 Sep;99(3):542-8
references: 12959443
references: Neurology. 2004 Mar 9;62(5 Suppl 2):S17-23
references: 15007160
references: Neurochem Int. 2008 May;52(6):935-47
references: 18093696
references: J Comp Physiol Psychol. 1969 Mar;67(3):370-5
references: 5787388
references: J Neurosci Res. 2001 May 15;64(4):418-28
references: 11340649
references: Cortex. 2007 Aug;43(6):792-805
references: 17710830
references: Pediatr Rev. 2008 Feb;29(2):e9-14
references: 18245299
references: Epilepsia. 2004 Dec;45(12):1539-48
references: 15571512
references: Epilepsia. 2007;48 Suppl 8:19-20
references: 18329989
references: Integr Physiol Behav Sci. 1992 Jan-Mar;27(1):66-83
references: 1576090
references: Neuroscience. 1984 Dec;13(4):1051-72
references: 6527789
references: J Neurosci. 2011 Oct 26;31(43):15397-406
references: 22031886
references: Neural Plast. 2007;2007:78970
references: 18060012
references: Neurobiol Learn Mem. 2009 May;91(4):333-42
references: 19041949
references: Neuron. 1990 Dec;5(6):745-56
references: 2148486
references: Epilepsia. 2008 May;49(5):832-41
references: 18076646
references: J Neurosci. 1989 Sep;9(9):3072-82
references: 2795152
references: Eur J Neurosci. 2004 Jun;19(12):3255-65
references: 15217382
references: Epilepsia. 2007;48 Suppl 9:30-2
references: 18047598
references: Neurosci Biobehav Rev. 2001 May;25(3):261-73
references: 11378180
references: J Neurosci. 2009 Feb 18;29(7):2103-12
references: 19228963
references: Cell Mol Neurobiol. 2003 Oct;23(4-5):727-38
references: 14514027
references: J Mol Neurosci. 2005;25(3):285-98
references: 15800381
references: Neuron. 2005 Oct 20;48(2):175-87
references: 16242399
references: Psychol Bull. 1976 May;83(3):482-504
references: 17582919
references: Mol Psychiatry. 2001 Jan;6(1):13-34
references: 11244481
references: Epilepsia. 2007;48 Suppl 2:4-12
references: 17571348
references: Neuroscience. 1980;5(6):991-1014
references: 7402461
references: Epilepsy Curr. 2004 Mar;4(2):43-46
references: 15562299
references: Ann N Y Acad Sci. 2003 Apr;985:389-410
references: 12724173
references: Epilepsia. 1999;40 Suppl 1:S23-33; discussion S40-1
references: 10421558
references: Neuroscience. 1984 Dec;13(4):1073-94
references: 6527790
references: Nat Rev Neurosci. 2005 Jun;6(6):463-75
references: 15891777
references: Brain Res. 1981 Aug 10;218(1-2):299-318
references: 7272738
references: Hippocampus. 2006;16(12):1032-60
references: 17094147
references: Neurology. 1999 Sep 22;53(5):915-21
references: 10496246
references: Brain Res Dev Brain Res. 1992 Feb 21;65(2):227-36
references: 1572066
references: Neuroscience. 1998 Sep;86(2):449-59
references: 9881860
references: Ment Retard Dev Disabil Res Rev. 2000;6(4):242-52
references: 11107189
references: Ment Retard Dev Disabil Res Rev. 2003;9(3):149-54
references: 12953293
references: Brain Res Brain Res Rev. 2004 Aug;46(1):71-117
references: 15297155
references: Child Psychiatry Hum Dev. 1999 Spring;29(3):189-208
references: 10080962
references: Epilepsy Behav. 2007 Mar;10(2):213-8
references: 17257900
references: Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1945-9
references: 8700864
references: Epilepsia. 1993 May-Jun;34(3):420-32
references: 8504777
references: Ann N Y Acad Sci. 2003 Apr;985:420-44
references: 12724175
references: Physiol Behav. 2001 Aug;73(5):781-92
references: 11566211
references: Neurosci Biobehav Rev. 1995 Summer;19(2):235-40
references: 7630579
references: Ment Retard Dev Disabil Res Rev. 2004;10(2):101-5
references: 15362164
references: Biol Neonate. 2000 Feb;77(2):69-82
references: 10657682
references: Acta Neurol Scand Suppl. 2007;186:7-15
references: 17784531
references: Epilepsia. 2007;48 Suppl 2:75-82
references: 17571355
references: Nat Rev Neurosci. 2004 Jul;5(7):583-9
references: 15208700
references: J Comp Physiol Psychol. 1979 Feb;93(1):74-104
references: 221551
references: Epilepsia. 2005;46 Suppl 5:113-7
references: 15987264
references: Epilepsy Behav. 2005 Sep;7(2):161-71
references: 16054870
references: Int J Dev Neurosci. 1988;6(5):431-8
references: 3202002
references: Dev Neuropsychol. 2000;18(2):237-72
references: 11280966
references: Epilepsy Behav. 2009 Feb;14(2):293-9
references: 19068237
references: Brain Res. 1982 Oct 28;250(1):178-82
references: 7139314
references: Pediatr Neurol. 2005 Jan;32(1):1-10
references: 15607597
references: Hippocampus. 2005;15(5):562-78
references: 15884034
references: Neuroendocrinology. 1974;14(6):351-5
references: 4416216
references: Trends Neurosci. 2006 Jul;29(7):414-418
references: 16713634
references: J Neurosci. 2008 Sep 10;28(37):9133-44
references: 18784294
references: J Child Neurol. 2007 May;22(5 Suppl):21S-9S
references: 17690084
references: Behav Brain Res. 1999 Apr;100(1-2):225-35
references: 10212070
references: Brain. 2005 Dec;128(Pt 12):2822-9
references: 16014650
references: Neuroscience. 1996 Sep;74(2):541-51
references: 8865204
references: Physiol Behav. 1982 Jul;29(1):41-5
references: 7122733
references: Int J Dev Neurosci. 2008 Nov;26(7):779-90
references: 18687397
references: Brain Res Dev Brain Res. 1994 Jan 14;77(1):133-6
references: 7510587
references: Eur J Neurosci. 2001 Oct;14(7):1143-52
references: 11683906
references: Brain Res. 1984 Mar;315(1):139-48
references: 6722574
references: Annu Rev Neurosci. 1999;22:105-22
references: 10202533
references: Brain Res Dev Brain Res. 1989 May 1;47(1):113-22
references: 2736759
references: Behav Neurosci. 2002 Jun;116(3):472-8
references: 12049328
references: Epilepsy Behav. 2000 Feb;1(1):52-9
references: 12609127
references: Neurology. 2004 Mar 9;62(5):708-13
references: 15007118
references: Hippocampus. 1998;8(6):608-19
references: 9882018
references: Epilepsia. 1999;40 Suppl 10:S2-20
references: 10609602