title: Acid-base and potassium homeostasis.
abstract: Acid-base balance and potassium disorders are often clinically linked. Importantly, acid-base disorders alter potassium transport. In general, acidosis causes decreased K(+) secretion and increased reabsorption in the collecting duct. Alkalosis has the opposite effects, often leading to hypokalemia. Potassium disorders also influence acid-base homeostasis. Potassium depletion causes increased H(+) secretion, ammoniagenesis and H-K-ATPase activity. Hyperkalemia decreases ammoniagenesis and NH4(+) transport in the thick ascending limb. Some combined potassium and acid-base disorders involve indirect factors such as aldosterone, impaired renal function, volume depletion, and diarrhea. In summary, disorders of potassium and acid-base homeostasis are mechanistically linked and clinically important.
authors: Departments of Medicine and Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA, USA. Lhamm@tulane.edu
authors: L
authors: L
authors: Lee Hamm
authors: Kathleen S
authors: KS
authors: Hering-Smith
authors: Nazih L
authors: NL
authors: Nakhoul
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000137:Acid-Base Imbalance / Q000378:metabolism / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006947:Hyperkalemia / Q000378:metabolism / Q000503:physiopathology; D007008:Hypokalemia / Q000378:metabolism / Q000503:physiopathology; D007684:Kidney Tubules / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*
chemical_list: D011188:Potassium
keywords: Renal K(+) regulation; acidosis; aldosterone; alkalosis; ammonia; hyperkalemia; hypokalemia; pH; potassium disorders