title: Into the wild: digging at immunology's evolutionary roots.
abstract: The two pillars of modern immunology have been man and mouse; in both settings, investigators seek to reduce complexity and control environmental conditions. However, the world outside the laboratory is immensely variable; this is not 'noise' but represents the genetic and environmental framework in which the immune system evolved and functions. Placing the ever-growing understanding of immunological mechanisms in wider real-world contexts is a massive but fundamentally important challenge.
authors: Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK. r.maizels@ed.ac.uk
authors: Rick M
authors: RM
authors: Maizels
authors: Daniel H
authors: DH
authors: Nussey
mesh_terms: D000486:Allergy and Immunology / Q000639:trends; D000818:Animals; D005075:Biological Evolution; D004777:Environment; D006801:Humans; D007107:Immune System / Q000502:physiology*
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