title: Uranium deposition in bones of Wistar rats associated with skeleton development.
abstract: Sixty female Wistar rats were submitted to a daily intake of ration doped with uranium from weaning to adulthood. Uranium in bone was quantified by the SSNTD (solid state nuclear track detection) technique, and bone mineral density (BMD) analysis performed. Uranium concentration as a function of age exhibited a sharp rise during the first week of the experiment and a drastic drop of 70% in the following weeks. Data interpretation indicates that uranium mimics calcium. Results from BMD suggest that radiation emitted by the incorporated Uranium could induce death of bone cells.
authors: Physics Institute University of São Paulo, São Paulo-SP, Brazil; Veterinary Medicine School, Methodist University, São Paulo-SP, Brazil. Electronic address: arruda@usp.br.
authors: G
authors: G
authors: Rodrigues
authors: J D T
authors: JD
authors: Arruda-Neto
authors: R M R
authors: RM
authors: Pereira
authors: S R
authors: SR
authors: Kleeb
authors: L P
authors: LP
authors: Geraldo
authors: M C
authors: MC
authors: Primi
authors: L
authors: L
authors: Takayama
authors: T E
authors: TE
authors: Rodrigues
authors: G T
authors: GT
authors: Cavalcante
authors: G C
authors: GC
authors: Genofre
authors: R
authors: R
authors: Semmler
authors: G P
authors: GP
authors: Nogueira
authors: E M
authors: EM
authors: Fontes
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D015519:Bone Density / Q000528:radiation effects; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects*; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000528:radiation effects; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D014501:Uranium / Q000009:adverse effects* / Q000493:pharmacokinetics*
chemical_list: D014501:Uranium; D002118:Calcium
keywords: Bone mineral density; Radiobiological effects; Skeleton bones; Uranium incorporation; Wistar rats