title: Evaluation of vasomotor reactivity in systemic lupus erythematosus patients and its comparison with the control group.
abstract: BACKGROUND
  Neuropsychiatric abnormalities are among the most common manifestations of systemic lupus erythematosus (SLE). They have been proposed to be associated with impaired cerebral blood flow (CBF). Cerebral vasomotor reactivity (VMR) is a hemodynamic parameter effective in the autoregulation of CBF. The aim of the present study is to determine and compare the VMR of women with stable SLE and normal women.
  
  
  METHODS
  According to the study criteria 60 women in each group entered the study. VMR was evaluated with Transcranial Doppler (TCD) at rest and after one minute of breath holding.
  
  
  RESULTS
  There was no significant difference in the mean of age between two groups (31.76 ± 7.50 years in the SLE group versus 32.43 ± 4.55 years in the control group, P value: 0.64). The mean duration of SLE in the case group was 5.40 ± 3.60 years. The means of the Breath-Holding Index (BHI) in the SLE and control groups were 0.842 ± 0.72% and 0.815 ± 0.26%, respectively, which was not significantly different (P value: 0.82).
  
  
  CONCLUSIONS
  This study indicates that the VMR of women with stable SLE is not significantly different from the age- and sex-matched normal population. However, further investigations on patients with longer SLE duration and more neuropsychological abnormality rates are suggested.
authors: Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Fariborz
authors: F
authors: Khorvash
authors: Elham
authors: E
authors: Shirani
authors: Gholam Reza
authors: GR
authors: Askari
authors: Seyed Ali
authors: SA
authors: Mousavi
authors: Zahra
authors: Z
authors: Sayedbonakdar
authors: Alimohammad
authors: A
authors: Fatemi
keywords: Cerebral blood flow; systemic lupus erythematosus; transcranial Doppler; vasomotor reactivity
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