title: Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
abstract: BACKGROUND
  A variety of surgical procedures are now available for tissue reconstruction after osteosarcoma excision, and an important prognostic factor is the evaluation of response to chemotherapy using histology. Although tumor-bearing autografts are useful tools for reconstruction, re-use of the primary tumor may make it difficult to assess the histological response to chemotherapy, since the entire tumor cannot be analyzed. Here, we analyzed the prognostic value of the histological response in the patients who received frozen tumor-bearing autografts for reconstruction.
  
  
  METHODS
  Retrospective analysis of the medical records of 51 patients with high-grade osteosarcoma of the extremities was performed. All patients received reconstruction using frozen tumor-bearing autografts. Tumor necrosis was evaluated in extraskeletal masses and cancellous bone.
  
  
  RESULTS
  Five-year overall survival of patients with good and poor response to chemotherapy was 82.9% and 46.4%, respectively (P = 0.044), and 5-year event-free survival was 57.7% and 36.0%, respectively (P = 0.329). Multivariate analysis revealed that a poor histological response to chemotherapy was a significant prognostic factor for overall survival (P = 0.033).
  
  
  CONCLUSIONS
  Histological response is an important and reliable prognostic factor in patients undergoing reconstruction using frozen tumor-bearing autografts.
authors: Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors: Shinji
authors: S
authors: Miwa
authors: Akihiko
authors: A
authors: Takeuchi
authors: Hiroko
authors: H
authors: Ikeda
authors: Toshiharu
authors: T
authors: Shirai
authors: Norio
authors: N
authors: Yamamoto
authors: Hideji
authors: H
authors: Nishida
authors: Katsuhiro
authors: K
authors: Hayashi
authors: Yoshikazu
authors: Y
authors: Tanzawa
authors: Hiroaki
authors: H
authors: Kimura
authors: Kentaro
authors: K
authors: Igarashi
authors: Hiroyuki
authors: H
authors: Tsuchiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D064592:Autografts; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016025:Bone Transplantation / Q000379:methods; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
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