title: Active polyketides isolated from Penicillium herquei.
abstract: In this work we are reporting the isolation by classical methods of chromatography of six polyketides from Penicillium herquei. The compounds citreorosein ( 1) , emodin ( 2) , janthinone ( 3) , citrinin ( 4) , citrinin H1 ( 5) and dicitrinol ( 6) were identified by spectral methods of 1D and 2D NMR and MS. Compounds 1, 2 and 3 were tested against promastigotes forms of Leishmania brasiliensis and 1 and 2 were also assayed against Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis and showed good activity.
authors: Faculdade de Química, Universidade Federal do Pará, 66075-110 Belém, PA, Brasil. andrey@ufpa.br
authors: Andrey M R
authors: AM
authors: Marinho
authors: Patrícia S B
authors: PS
authors: Marinho
authors: Lourivaldo S
authors: LS
authors: Santos
authors: Edson
authors: E
authors: Rodrigues Filho
authors: Izabel C P
authors: IC
authors: Ferreira
mesh_terms: D000880:Anthraquinones / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D002953:Citrinin / Q000494:pharmacology; D004642:Emodin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D007892:Leishmania braziliensis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021261:Parasitic Sensitivity Tests; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000880:Anthraquinones; D061065:Polyketides; D002953:Citrinin; D004642:Emodin; C540595:citreorosein