title: Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome.
abstract: Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 ± 0.32 μmol/L, p = 0.0022) and malondialdehyde (0.77 ± 0.11 μmol/L, p < 0.001) in sera of MDS patients vs controls (asymmetric dimethylarginine: 0.56 ± 0.16 μmol/L, malondialdehyde: 0.52 ± 0.07 μmol/L). On the contrary, nitrites concentrations were significantly decreased in MDS patients (1.71 ± 0.46 μmol/L, p = 0.0028) vs controls (2.16 ± 0.38 μmol/L). We suppose that the oxidative stress in MDS is enhanced due to methylated arginines influence on NO synthase activity impairment.
authors: Jana
authors: J
authors: Štikarová
authors: Jiří
authors: J
authors: Suttnar
authors: Kristýna
authors: K
authors: Pimková
authors: Leona
authors: L
authors: Chrastinová-Mášová
authors: Jaroslav
authors: J
authors: Čermák
authors: Jan E
authors: JE
authors: Dyr
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine
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