title: Bumping up kinase activity with an ATP-derived neo-substrate.
abstract: Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.
authors: Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA. rkleiner@rockefeller.edu
authors: Ralph E
authors: RE
authors: Kleiner
authors: Tarun M
authors: TM
authors: Kapoor
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010300:Parkinson Disease / Q000473:pathology*; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase