title: Two-photon oxygen sensing with quantum dot-porphyrin conjugates.
abstract: Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO2) in organic solvents. Palladium porphyrins are sensitive in the 0-160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. Appreciable overlap between QD emission and porphyrin absorption features results in efficient Förster resonance energy transfer (FRET) for signal transduction in these sensors. The QD serves as a photon antenna, enhancing porphyrin emission under both one- and two-photon excitation, demonstrating that QD-palladium porphyrin conjugates may be used for oxygen sensing over physiological oxygen ranges.
authors: Department of Chemistry, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
authors: Christopher M
authors: CM
authors: Lemon
authors: Elizabeth
authors: E
authors: Karnas
authors: Moungi G
authors: MG
authors: Bawendi
authors: Daniel G
authors: DG
authors: Nocera
mesh_terms: D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D017785:Photons; D011166:Porphyrins / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D017646:Organosilicon Compounds; D011166:Porphyrins; D010165:Palladium; D010100:Oxygen
references: Chem Commun (Camb). 2011 Jan 7;47(1):325-7
references: 20730204
references: Science. 2005 Jan 7;307(5706):58-62
references: 15637262
references: J Org Chem. 2008 Sep 5;73(17):6728-42
references: 18683982
references: Langmuir. 2006 Mar 28;22(7):3007-13
references: 16548550
references: Anal Biochem. 2002 Nov 15;310(2):191-8
references: 12423638
references: Chem Soc Rev. 2007 Apr;36(4):579-91
references: 17387407
references: J Am Chem Soc. 2012 Apr 11;134(14):6401-8
references: 22414052
references: Annu Rev Chem Biomol Eng. 2011;2:281-98
references: 22432620
references: J Neurosci Methods. 2013 Mar 30;214(1):45-51
references: 23333398
references: J Org Chem. 2008 Aug 15;73(16):6187-201
references: 18637693
references: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references: 18156677
references: Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4148-51
references: 22344795
references: Cancer Res. 1989 Dec 1;49(23):6449-65
references: 2684393
references: J Am Chem Soc. 2008 Apr 30;130(17):5720-5
references: 18393422
references: Angew Chem Int Ed Engl. 2010 Jul 5;49(29):4907-9
references: 20540131
references: Nat Biotechnol. 2003 Nov;21(11):1369-77
references: 14595365
references: Nat Med. 2001 Jul;7(7):864-8
references: 11433354
references: Phys Chem Chem Phys. 2009 Nov 14;11(42):9850-60
references: 19851565
references: J Am Chem Soc. 2009 Sep 16;131(36):12994-3001
references: 19697933
references: Chemphyschem. 2008 Aug 25;9(12):1673-9
references: 18663708
references: Curr Opin Biotechnol. 2009 Feb;20(1):37-44
references: 19216068
references: Appl Opt. 2006 Jun 1;45(16):3760-7
references: 16724134
references: Nano Lett. 2001 Apr;1(4):207-211
references: 35897166
references: Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):39-43
references: 22171005
references: Science. 2003 May 30;300(5624):1434-6
references: 12775841
references: Analyst. 2011 Mar 7;136(5):962-7
references: 21170467
references: Chemistry. 2002 Mar 1;8(5):1181-8
references: 11891906
references: Chem Biodivers. 2008 Jan;5(1):153-61
references: 18205117
references: J Org Chem. 2005 Apr 29;70(9):3500-10
references: 15844983
references: J Am Chem Soc. 2005 Aug 24;127(33):11851-62
references: 16104764
references: J Phys Chem B. 2005 May 12;109(18):8679-92
references: 16852028
references: Annu Rev Biochem. 1971;40:83-114
references: 4331120
references: Nat Biotechnol. 2004 Jan;22(1):47-52
references: 14704706
references: J Am Chem Soc. 2006 Oct 18;128(41):13320-1
references: 17031920
references: Org Biomol Chem. 2009 Mar 21;7(6):1093-6
references: 19262927
references: Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1165-9
references: 23225635
references: Angew Chem Int Ed Engl. 2008;47(39):7450-3
references: 18729125
references: J Phys Chem B. 2010 Nov 18;114(45):14373-82
references: 20462225
references: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3011-6
references: 19218443
references: Photochem Photobiol Sci. 2010 Jan;9(1):103-9
references: 20062850
references: J Phys Chem A. 2007 Aug 2;111(30):6977-90
references: 17608457
references: J Org Chem. 2000 Apr 7;65(7):2249-52
references: 10774058
references: Chem Sci. 2012;3(10):2980-2985
references: 26413260
references: Small. 2006 Nov;2(11):1308-13
references: 17192978
references: Nat Rev Drug Discov. 2007 Apr;6(4):273-86
references: 17396134
references: Nat Mater. 2003 Sep;2(9):630-8
references: 12942071
references: J Org Chem. 2007 Sep 28;72(20):7701-14
references: 17824652
references: Dalton Trans. 2008 Mar 14;(10):1341-5
references: 18305846
references: J Org Chem. 2004 Nov 26;69(24):8356-65
references: 15549807
references: Inorg Chem. 2005 Dec 12;44(25):9232-41
references: 16323904
references: Science. 2000 Feb 11;287(5455):1011-3
references: 10669406
references: Chem Pharm Bull (Tokyo). 2001 Mar;49(3):287-93
references: 11253918
references: Angew Chem Int Ed Engl. 2002 Jun 17;41(12):2117-9
references: 19746614
references: Nat Med. 1997 Feb;3(2):177-82
references: 9018236
references: Annu Rev Phys Chem. 1996;47:555-606
references: 8930102
references: J Am Chem Soc. 2012 Jan 18;134(2):1172-80
references: 22121977
references: Acta Crystallogr C. 2008 Jan;64(Pt 1):m53-7
references: 18216441