title: Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells.
abstract: This is a case report of a 32-year-old man exposed to a total body dose of 14.5 Gy γ-radiation in a lethal (60)Co-source irradiation accident in 2008 in China. Frequent nausea, vomiting and marked neutropenia and lymphopenia were observed from 30 min to 45 h after exposure. HLA-mismatched peripheral blood stem cell transplantation combined with infusion of mesenchymal stem cells was used at Day 7. Rapid hematopoietic recovery, stable donor engraftment and healing of radioactive skin ulceration were achieved during Days 18-36. The patient finally developed intestinal obstruction and died of multi-organ failure on Day 62, although intestinal obstruction was successfully released by emergency bowel resection.
authors: Department of Hematology and Transplantation, Affiliated Hospital of the Academy of Military Medical Sciences, 8 Dongdajie, Beijing 100071, China.
authors: Mei
authors: M
authors: Guo
authors: Zheng
authors: Z
authors: Dong
authors: Jianhui
authors: J
authors: Qiao
authors: Changlin
authors: C
authors: Yu
authors: Qiyun
authors: Q
authors: Sun
authors: Kaixun
authors: K
authors: Hu
authors: Guangxian
authors: G
authors: Liu
authors: Li
authors: L
authors: Wei
authors: Bo
authors: B
authors: Yao
authors: Qiuhong
authors: Q
authors: Man
authors: Xuedong
authors: X
authors: Sun
authors: Zhiqing
authors: Z
authors: Liu
authors: Zhiwu
authors: Z
authors: Song
authors: Chengze
authors: C
authors: Yu
authors: Ying
authors: Y
authors: Chen
authors: Qingliang
authors: Q
authors: Luo
authors: Sugang
authors: S
authors: Liu
authors: Hui-Sheng
authors: HS
authors: Ai
mesh_terms: D054508:Acute Radiation Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D003037:Cobalt Radioisotopes / Q000506:poisoning*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D036102:Peripheral Blood Stem Cell Transplantation; D018788:Radioactive Hazard Release
chemical_list: D003037:Cobalt Radioisotopes; D006680:HLA Antigens
keywords: HLA-mismatched stem cell transplantation; acute radiation syndrome; mesenchymal stem cell
references: Bone Marrow Transplant. 2002 Jun;29(11):935-9
references: 12080361
references: J Radiat Res. 2001 Sep;42 Suppl:S167-82
references: 11791750
references: Health Phys. 2010 Feb;98(2):172-8
references: 20065680
references: N Engl J Med. 2002 Sep 19;347(12):944-7; author reply 944-7
references: 12240687
references: J Radiol Prot. 2009 Sep;29(3):301-20
references: 19690364
references: N Engl J Med. 1989 Jul 27;321(4):205-12
references: 2664512
references: J Hematother Stem Cell Res. 2002 Jun;11(3):549-64
references: 12183840
references: JAMA. 1987 Aug 7;258(5):664-7
references: 3302322
references: Br J Radiol. 2007 Sep;80 Spec No 1:S49-55
references: 17704326
references: Stem Cells. 2009 May;27(5):1205-11
references: 19418462
references: Br J Radiol. 2003 Apr;76(904):246-53
references: 12711644
references: Ann Intern Med. 1988 Nov 1;109(9):730-44
references: 3056171
references: Int J Radiat Biol. 2010 Sep;86(9):800-8
references: 20636236
references: Lancet. 2004 May 1;363(9419):1439-41
references: 15121408
references: J Gene Med. 2003 Dec;5(12):1028-38
references: 14661178
references: Blood. 2007 Oct 1;110(7):2764-7
references: 17638847
references: Biol Blood Marrow Transplant. 2009 Aug;15(8):930-7
references: 19589482
references: Blood. 2003 Aug 15;102(4):1541-7
references: 12714500
references: Health Phys. 1997 Apr;72(4):513-8
references: 9119674
references: Leukemia. 2003 Oct;17(10):2052-4
references: 14513058
references: Blood. 2008 Jun 15;111(12):5757-8; author reply 5758-9
references: 18544701
references: Ann Hematol. 2006 Oct;85(10):671-9
references: 16896913