title: Donor-associated malignancy in kidney transplant patients.
abstract: Skin cancer cells with donor genotype have been identified in allogeneic transplant patients; however, the donor contribution to the recipient's epithelial malignancy remains to be established. In this issue of the JCI, Verneuil et al. provide the first evidence for donor contribution to the malignant epithelium of skin squamous cell carcinoma in a kidney transplant recipient. This case report may have important implications for cancer research and clinical care of long-surviving kidney transplant patients.
authors: Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.
authors: Cai-Bin
authors: CB
authors: Cui
authors: David A
authors: DA
authors: Gerber
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000209:etiology*
references: Br J Dermatol. 2000 Sep;143(3):513-9
references: 10971322
references: J Am Soc Nephrol. 2010 May;21(5):852-8
references: 20431040
references: Int J Cancer. 2009 Oct 15;125(8):1747-54
references: 19444916
references: Blood. 2007 Apr 1;109(7):2688-92
references: 17132724
references: J Clin Invest. 2013 Sep;123(9):3797-801
references: 23979160
references: Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6229-34
references: 21444804
references: Transplant Proc. 2011 Oct;43(8):2887-90
references: 21996180
references: Br J Dermatol. 2009 Nov;161 Suppl 3:85-9
references: 19775362
references: Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6
references: 21502497
references: J Clin Invest. 2007 Jul;117(7):1893-901
references: 17607363
references: J Am Acad Dermatol. 1999 Feb;40(2 Pt 1):177-86
references: 10025742
references: Transplantation. 2002 Feb 15;73(3):379-86
references: 11884934
references: Biol Blood Marrow Transplant. 2011 Jun;17(6):771-89
references: 20951819
references: Br J Dermatol. 2006 Mar;154(3):498-504
references: 16445782
references: Hum Mutat. 2003 Mar;21(3):313-20
references: 12619118
references: Cancer Res. 2005 Mar 1;65(5):1755-60
references: 15753371
references: N Engl J Med. 2003 Apr 24;348(17):1681-91
references: 12711744
references: Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2:S87-S100
references: 18309007