title: Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine.
abstract: Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM -biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways.
authors: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors: Ligeng
authors: L
authors: Xu
authors: Ye
authors: Y
authors: Liu
authors: Zhiyun
authors: Z
authors: Chen
authors: Wei
authors: W
authors: Li
authors: Ying
authors: Y
authors: Liu
authors: Liming
authors: L
authors: Wang
authors: Liying
authors: L
authors: Ma
authors: Yiming
authors: Y
authors: Shao
authors: Yuliang
authors: Y
authors: Zhao
authors: Chunying
authors: C
authors: Chen
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects / Q000737:chemistry* / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D037741:Fullerenes / Q000009:adverse effects / Q000737:chemistry* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D012449:Safety; D019444:Vaccines, DNA / Q000009:adverse effects / Q000737:chemistry* / Q000276:immunology; D058425:Vaccines, Virus-Like Particle / Q000009:adverse effects / Q000737:chemistry* / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D037741:Fullerenes; D019444:Vaccines, DNA; D058425:Vaccines, Virus-Like Particle; C108127:fullerenol
keywords: HIV-1; fullerenol; nano-adjuvant; vaccine; virus-like particle