title: A chemical logic for reprogramming to pluripotency.
abstract: Pluripotency can be experimentally induced from somatic cells by nuclear transfer, fusion with embryonic stem cells, or ectopic transcription factor induction, but attempts to recapitulate this process by chemical means alone have previously failed. In a recent paper published in Science, Hou et al. pursue a rational, albeit laborious approach to identify cocktails of small molecules whose treatment restores pluripotency in adult somatic cells.
authors: 1] Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA [3] Broad Institute, Boston, MA 02115, USA [4] Harvard Stem Cell Institute, Boston, MA 02115, USA.
authors: Alejandro
authors: A
authors: De Los Angeles
authors: George Q
authors: GQ
authors: Daley
mesh_terms: D000818:Animals; D060846:Cell Engineering / Q000379:methods*; D065150:Cellular Reprogramming / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects*; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D054852:Small Molecule Libraries / Q000494:pharmacology*
chemical_list: D054852:Small Molecule Libraries
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