title: The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy.
abstract: BACKGROUND
  Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) due to decreasing quality of life. In the present study, it is aimed to evaluate angiotensin-converting enzyme (ACE) Gene I/D polymorphism in Turkish population.
  
  
  METHODS
  Two hundred and thirty-five DPN patients and two hundred and eighty-one controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses for the ACE gene I/D polymorphism.
  
  
  RESULTS
  Baseline characteristics of the DPN patients according to ACE genotypes were similar, except for history of hypertension. The frequency of II genotype was significantly higher in patients with positive history of hypertension than the patients with negative history of hypertension (p=0.013). DD genotype of I/D polymorphism was found to be a susceptibility factor for DPN in homozygous form (p=0.032). According to allele frequencies, D allele of I/D polymorphism was found to be a susceptibility factor for DPN (p=0.031).
  
  
  CONCLUSIONS
  ACE gene I/D polymorphism may research in DM patients to determine genetic predisposition for DPN. It can be useful for taking early measures and avoiding DPN in a Turkish population.
authors: Gaziosmanpasa University, Faculty of Medicine, Department of Physical Therapy and Rehabilitation, Tokat, Turkey.
authors: Ahmet
authors: A
authors: Inanir
authors: Nursah
authors: N
authors: Basol
authors: Nevin
authors: N
authors: Karakus
authors: Serbulent
authors: S
authors: Yigit
mesh_terms: D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D003929:Diabetic Neuropathies / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000473:pathology; D007532:Isoleucine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007532:Isoleucine; D001224:Aspartic Acid; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; Bp; Diabetic peripheral neuropathy; Gene Polymorphism; base pair