title: Synthesis of 3-tetrazolylmethyl-azepino[4,5-b]indol-4-ones in two reaction steps: (Ugi-azide/N-acylation/SN2)/free radical cyclization and docking studies to a 5-Ht(6) model.
abstract: A series of nine novel 3-tetrazolylmethyl-azepino[4,5-b]indol-4-ones were prepared in moderate to good overall yields in only two reaction steps. The first step consisted of a one-pot sequential process of an Ugi-azide multicomponent reaction, N-acylation and SN2 to give the xanthates. The second step was an intramolecular cyclization under free radical conditions. Also, their binding modes have been modelled using docking techniques.
authors: Departamento de Química and Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato, C.P. 36050, Guanajuato, México. rociogm@ugto.mx.
authors: Raul E
authors: RE
authors: Gordillo-Cruz
authors: Angel
authors: A
authors: Rentería-Gómez
authors: Alejandro
authors: A
authors: Islas-Jácome
authors: Carlos J
authors: CJ
authors: Cortes-García
authors: Erik
authors: E
authors: Díaz-Cervantes
authors: Juvencio
authors: J
authors: Robles
authors: Rocío
authors: R
authors: Gámez-Montaño
mesh_terms: D000215:Acylation; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D001381:Azepines; D001386:Azides; D005609:Free Radicals; D007211:Indoles