title: Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in extraribosomal function, persistence, and drug resistance based on transcriptome data.
abstract: Ribosome, the protein synthesis machinery essential for all living cells, consists of ribosomal proteins and RNA. Extraribosomal functions have recently been discovered for many ribosomal proteins, acting either as individual regulatory proteins or as a complex with other cell components. However, extraribosomal functions of Mycobacterium tuberculosis ribosomal proteins have not been systematically addressed. To this end, M. tuberculosis ribosomal proteins potentially engaged in extraribosomal functions were curated by data mining from transcriptional profiles of M. tuberculosis exposed to diverse treatments. Six M. tuberculosis ribosomal proteins, namely, S3 (Rv0707, rpsC), L16 (Rv0708, rplP), L29 (Rv0709, rpmC), S17 (Rv0710, rpsQ), S14 (Rv2056c, rpsN2), and L33 (Rv2057c, rpmG1), were found to behave idiosyncratically. The function of these abnormal ribosomal subunits can be further explored. Special emphasis is on their potential value as novel targets for better antibiotics.
authors: a Key Laboratory of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, State Key Laboratory Breeding Base of Eco-Enviroment and Bio-Resource of the Three Gorges Area , School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University , Beibei, Chongqing , 400700 , China .
authors: Xiangyu
authors: X
authors: Fan
authors: Xiemei
authors: X
authors: Tang
authors: Jianlong
authors: J
authors: Yan
authors: Jianping
authors: J
authors: Xie
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics*; D010588:Phagosomes / Q000187:drug effects / Q000378:metabolism; D060066:Protein Interaction Maps / Q000187:drug effects; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism*; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects / Q000235:genetics; D059467:Transcriptome / Q000235:genetics*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D021122:Protein Subunits; D012269:Ribosomal Proteins
keywords: Mycobacterium tuberculosis; data mining; extraribosomal function; ribosomal proteins