title: Is bone marrow biopsy always indicated in patients with primary cutaneous marginal zone B-cell lymphoma?
abstract: Bone marrow involvement at the time of diagnosis is uncommon in patients with primary cutaneous marginal zone B-cell lymphoma (PCMZL). Moreover, in these patients such involvement is rarely found in isolation on diagnosis. Typically the few patients with PCMZL who have early bone marrow involvement also present secondary nodal or visceral involvement, which is detected by other staging studies (usually computed tomography). In recent years, this has given rise to some debate about whether a bone marrow biopsy should be routinely performed in patients diagnosed with PCMZL in view of the good prognosis and low incidence of bone marrow infiltration and/or extracutaneous involvement in this type of lymphoma.
authors: Servicio de Dermatología, Hospital de Viladecans, Barcelona, Spain. Electronic address: cristinamuniesa@hotmail.com.
authors: C
authors: C
authors: Muniesa
authors: B
authors: B
authors: Hernández-Machín
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination / Q000706:statistics & numerical data; D003955:Diagnostic Tests, Routine; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification; D018442:Lymphoma, B-Cell, Marginal Zone / Q000145:classification / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification; D009367:Neoplasm Staging / Q000379:methods; D049268:Positron-Emission Tomography; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D019564:Unnecessary Procedures; D014944:World Health Organization
keywords: Afectación extracutánea; Biopsia de médula ósea; Bone marrow biopsy; Extracutaneous involvement; Linfoma primario cutáneo de células B de la zona marginal; Primary cutaneous marginal zone B-cell lymphoma