title: Serum Fetuin-A levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.
abstract: This study was designed to determine serum Fetuin-A levels and establish whether serum Fetuin-A level is related with insulin resistance, oxidative stress, ovarian hyperandrogenism and dyslipidemia in women with polycystic ovary syndrome (PCOS). Twenty-two patients with PCOS and twenty-one healthy control women were evaluated in this controlled clinical study. Serum Fetuin-A, lipid fractions, glucose, insulin, malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), superoxide dismutase (SOD) and other hormone (gonadotropins, androgens) levels were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-R). The women with PCOS had significantly higher serum fasting glucose, insulin, luteinizing hormone (LH), MDA, Fetuin-A levels, and LH/follicle-stimulating hormone (FSH) ratio, free androgen index (FAI), HOMA-IR than healthy women. However, sex hormone-binding globulin (SHBG) and GSH levels were significantly lower in patients with PCOS compared with controls. Fetuin-A was positively correlated with insulin, HOMA-IR and FAI. Multiple regression analysis revealed that FAI was strong predictor of serum Fetuin-A level. Serum Fetuin-A level was related with insulin resistance and ovarian hyperandrogenism in women with PCOS. These results suggest that Fetuin-A may have a role in triggering the processes leading to insulin resistance and androgen excess in PCOS.
authors: Department of Biochemistry, Pamukkale University, School of Medicine , Denizli , Turkey .
authors: Yasar
authors: Y
authors: Enli
authors: Semin Melahat
authors: SM
authors: Fenkci
authors: Veysel
authors: V
authors: Fenkci
authors: Ozer
authors: O
authors: Oztekin
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis*
chemical_list: D000728:Androgens; D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D060749:alpha-2-HS-Glycoprotein; D008315:Malondialdehyde; C075709:glutathiohydroxyacetone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D009195:Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione