title: [Antitumor activity of dihydrobetulonic acid amides in vitro and in vivo].
abstract: Amides with homopiperidinic and piperazinic cycles were synthesized from dihydrobetulonic acid which was obtained by dihydrobetulin oxidation. All substances have shown high antitumor activity (CCID50 3.5-36.2 microM) in vitro in lymphoid (CEM-13, U-937) and monocytic (MT-4) human cell lines. Amides with methyl- and ethyl-piperazinic residues don't influence viability of Lung Lewis Carcinoma cell in culture and haven't any significant effect to its transplantates in C57BL/6 mice. But such amides inhibit efficiently the metastatic elaboration in lung of these mice. The antimetastatic activity increases followed by the change of aliphatic residue length in piperazinic cycle from methyl to ethyl.
authors: I V
authors: IV
authors: Sorokina
authors: I Iu
authors: IIu
authors: Maĭnagashev
authors: N A
authors: NA
authors: Zhukova
authors: D V
authors: DV
authors: Korchagina
authors: T G
authors: TG
authors: Tolstikova
authors: V P
authors: VP
authors: Nikolin
authors: N A
authors: NA
authors: Popova
authors: M A
authors: MA
authors: Pokrovskiĭ
authors: A G
authors: AG
authors: Pokrovskiĭ
authors: N F
authors: NF
authors: Salakhutdinov
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D009828:Oleanolic Acid; C118308:betulonic acid; D000094062:Betulinic Acid