title: The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons.
abstract: The anandamide monounsaturated analogue oleoylethanolamide (OEA) acts as satiety signal released from enterocytes upon the ingestion of dietary fats to prolong the interval to the next meal. This effect, which requires intact vagal fibers and intestinal PPAR-alpha receptors, is coupled to the increase of c-fos and oxytocin mRNA expression in neurons of the paraventricular nucleus (PVN) and is prevented by the intracerebroventricular administration of a selective oxytocin antagonist, thus suggesting a necessary role of oxytocinergic neurotransmission in the pro-satiety effect of OEA. By brain microdialysis and immunohistochemistry, in this study we demonstrate that OEA treatment can stimulate oxytocin neurosecretion from the PVN and enhance oxytocin expression at both axonal and somatodendritic levels of hypothalamic neurons. Such effects, which are maximum 2h after OEA administration, support the hypothesis that the satiety-inducing action of OEA is mediated by the activation of oxytocin hypothalamic neurons.
authors: Department of Physiology and Pharmacology, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
authors: Adele
authors: A
authors: Romano
authors: Tommaso
authors: T
authors: Cassano
authors: Bianca
authors: B
authors: Tempesta
authors: Silvia
authors: S
authors: Cianci
authors: Pasqua
authors: P
authors: Dipasquale
authors: Roberto
authors: R
authors: Coccurello
authors: Vincenzo
authors: V
authors: Cuomo
authors: Silvana
authors: S
authors: Gaetani
mesh_terms: D000818:Animals; D063388:Endocannabinoids; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009829:Oleic Acids / Q000494:pharmacology*; D010121:Oxytocin / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012527:Satiation / Q000187:drug effects*
chemical_list: D063388:Endocannabinoids; D009829:Oleic Acids; C488250:oleoylethanolamide; D010121:Oxytocin