title: White matter atrophy in brain of neuromyelitis optica: a voxel-based morphometry study.
abstract: BACKGROUND
  Recent studies have shown that tissue damage in neuromyelitis optica (NMO) is not limited to the spinal cord and optic nerve but can also appear in the brain. Previous magnetic resonance imaging (MRI) studies have reported controversial findings regarding the presence of white matter atrophy in NMO patients.
  
  
  OBJECTIVE
  To investigate regional white matter changes in NMO using voxel-based morphometry (VBM).
  
  
  METHODS
  Conventional MRI and T1-weighted three-dimensional MRI were performed on 20 patients with NMO and 20 age- and sex-matched normal controls (NCs). The data were analyzed by statistical parametric mapping 5 (SPM5) to generate white matter concentration maps, and regional white matter concentrations were compared between the two groups. Relationships between the white matter concentration in regions with significant group differences and the Expanded Disability Status Scale (EDSS) and disease duration were further explored.
  
  
  RESULTS
  Compared to NCs, NMO patients had decreased white matter volumes in the right precentral gyrus, right postcentral gyrus, left middle and medial frontal gyrus, right superior frontal gyrus, bilateral inferior and superior parietal lobule, right angular gyrus, right middle occipital gyrus, and left precuneus. No significant correlation was found between white matter regions with volume reduction and the EDSS and disease duration in NMO.
  
  
  CONCLUSIONS
  We found white matter atrophy in several brain regions in the frontal, parietal, and occipital lobes in NMO, suggesting that subtle white matter damage relevant to the motor, vision, and cognition systems exists in NMO patients. The pattern of white matter atrophy in NMO is different from that in multiple sclerosis (MS).
authors: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Yunyun
authors: Y
authors: Duan
authors: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Yaou
authors: Y
authors: Liu
authors: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Peipeng
authors: P
authors: Liang
authors: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Xiuqin
authors: X
authors: Jia
authors: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Jing
authors: J
authors: Ye
authors: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
authors: Huiqing
authors: H
authors: Dong
authors: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China kunchengli55@gmail.com.
authors: Kuncheng
authors: K
authors: Li
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009471:Neuromyelitis Optica / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
keywords: Voxel-based morphometry; magnetic resonance imaging; neuromyelitis optica