title: Transient global amnesia associated with accidental high-frequency stimulation of the right hippocampus in deep brain stimulation for segmental dystonia.
abstract: We report on a 66-year-old woman with segmental dystonia treated with chronic bilateral deep brain stimulation of the globus pallidus internus, in whom accidental high-voltage, high-frequency stimulation induced an episode of transient global amnesia (TGA) via an electrode contact which was misplaced in the right hippocampus. A possible mechanism underlying this TGA episode may have been the inhibition of local neuronal activity or fiber activation by high current density via direct electrical stimulation of hippocampal structures. While a unifying etiology of TGA has not been proven so far, our case demonstrates a possible link between focal electrical stimulation of hippocampal structures and the full clinical picture of the syndrome.
authors: Department of Neurology, Universitaetsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
authors: Hansjörg
authors: H
authors: Baezner
authors: Christian
authors: C
authors: Blahak
authors: H Holger
authors: HH
authors: Capelle
authors: Christoph
authors: C
authors: Schrader
authors: Götz
authors: G
authors: Lütjens
authors: Joachim K
authors: JK
authors: Krauss
mesh_terms: D000368:Aged; D000648:Amnesia, Retrograde / Q000209:etiology* / Q000503:physiopathology; D020236:Amnesia, Transient Global / Q000209:etiology* / Q000503:physiopathology; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000295:instrumentation; D020821:Dystonic Disorders / Q000628:therapy*; D004556:Electric Injuries / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D004567:Electrodes, Implanted / Q000009:adverse effects; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology; D006624:Hippocampus / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008839:Microelectrodes / Q000009:adverse effects