title: Patient characteristics as predictors of clinical outcome of distraction in treatment of severe ankle osteoarthritis.
abstract: Osteoarthritis (OA) is a slowly progressive joint disease. Joint distraction can be a treatment of choice in case of severe OA. Prediction of failure will facilitate implementation of joint distraction in clinical practice. Patients with severe ankle OA, who underwent joint distraction were included. Survival analysis was performed over 12 years (n = 25 after 12 years). Regression analyses were used to predict failures and clinical benefit at 2 years after joint distraction (n = 111). Survival analysis showed that 44% of the patients failed, 17% within 2 years and 37% within 5 years after joint distraction (n = 48 after 5 years). Survival analysis in subgroups showed that the percentage failure was only different in women (30% after 2 years) versus men (after 11 years still no 30% failure). In the multivariate analyses female gender was predictive for failure 2 years after joint distraction. Gender and functional disability at baseline predicted more pain. Functional disability and pain at baseline were associated with more functional disability. Joint distraction shows a long-term clinical beneficial outcome. However, failure rate is considerable over the years. Female patients have a higher chance of failure during follow-up. Unfortunately, not all potential predictors could be investigated and other clinically significant predictors were not found.
authors: Rheumatology & Clinical Immunology, UMC Utrecht, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands.
authors: A C A
authors: AC
authors: Marijnissen
authors: M C L
authors: MC
authors: Hoekstra
authors: B C du
authors: BC
authors: Pré
authors: P M
authors: PM
authors: van Roermund
authors: J
authors: J
authors: van Melkebeek
authors: A
authors: A
authors: Amendola
authors: P
authors: P
authors: Maathuis
authors: F P J G
authors: FP
authors: Lafeber
authors: P M J
authors: PM
authors: Welsing
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000503:physiopathology* / Q000601:surgery*; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010003:Osteoarthritis / Q000503:physiopathology* / Q000601:surgery*; D019857:Osteogenesis, Distraction / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D020127:Recovery of Function; D012044:Regression Analysis; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: joint distraction; osteoarthritis; prediction