title: Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide.
abstract: There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O(6)-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributory role to the efficacy of TMZ treatment for pituitary carcinomas and atypical adenomas. The preserved MSH6 function might be essential for the responsiveness to TMZ treatment in pituitary carcinomas and atypical adenomas.
authors: Department of Neurosurgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan, akirakun@med.teikyo-u.ac.jp.
authors: Akira
authors: A
authors: Matsuno
authors: Mineko
authors: M
authors: Murakami
authors: Katsumi
authors: K
authors: Hoya
authors: Shoko M
authors: SM
authors: Yamada
authors: Shinya
authors: S
authors: Miyamoto
authors: So
authors: S
authors: Yamada
authors: Jae-Hyun
authors: JH
authors: Son
authors: Hajime
authors: H
authors: Nishido
authors: Fuyuaki
authors: F
authors: Ide
authors: Hiroshi
authors: H
authors: Nagashima
authors: Mutsumi
authors: M
authors: Sugaya
authors: Toshio
authors: T
authors: Hirohata
authors: Akiko
authors: A
authors: Mizutani
authors: Hiroko
authors: H
authors: Okinaga
authors: Yudo
authors: Y
authors: Ishii
authors: Shigeyuki
authors: S
authors: Tahara
authors: Akira
authors: A
authors: Teramoto
authors: R Yoshiyuki
authors: RY
authors: Osamura
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D003606:Dacarbazine; D019853:O(6)-Methylguanine-DNA Methyltransferase; D000077204:Temozolomide
references: ScientificWorldJournal. 2010 Nov 04;10:2132-8
references: 21057727
references: J Pharmacol Exp Ther. 2003 Feb;304(2):661-8
references: 12538819
references: J Clin Endocrinol Metab. 2002 Jul;87(7):3084-9
references: 12107205
references: Hormones (Athens). 2012 Jan-Mar;11(1):94-100
references: 22450349
references: Neurosurgery. 2011 Jun;68(6):E1761-7; discussion E1767
references: 21389894
references: Pituitary. 2011 Dec;14(4):418-24
references: 19960369
references: Cancer. 2006 Apr 15;106(8):1759-65
references: 16541434
references: Ann Oncol. 2005 Jun;16(6):950-7
references: 15829494
references: J Clin Endocrinol Metab. 2005 May;90(5):3089-99
references: 15741248
references: Exp Clin Endocrinol Diabetes. 2010 Nov;118(10):760-3
references: 20496311
references: Case Rep Endocrinol. 2012;2012:645914
references: 23091742
references: J Clin Neurosci. 2009 Dec;16(12):1694-6
references: 19818629
references: Pituitary. 2012 Mar;15(1):97-100
references: 20407837
references: J Spinal Cord Med. 2012 Mar;35(2):118-21
references: 22333938
references: Hum Pathol. 2007 Jan;38(1):185-9
references: 17056093
references: Cancer Res. 1999 Feb 15;59(4):793-7
references: 10029064
references: Neurosurgery. 1996 Apr;38(4):765-70; discussion 770-1
references: 8692397
references: Onco Targets Ther. 2013 Apr 15;6:371-89
references: 23620671
references: Med Mol Morphol. 2011 Jun;44(2):63-70
references: 21717308
references: Mutat Res. 2000 Apr;462(2-3):71-82
references: 10767619
references: J Neurosurg. 2010 Apr;112(4):750-5
references: 19698042
references: J Neurosurg. 1989 Apr;70(4):573-7
references: 2926498
references: Eur J Endocrinol. 2009 Jan;160(1):115-9
references: 18984772
references: J Clin Endocrinol Metab. 2013 Mar;98(3):1130-6
references: 23365123
references: Med Mol Morphol. 2005 Mar;38(1):36-42
references: 16158178
references: N Engl J Med. 2000 Nov 9;343(19):1350-4
references: 11070098
references: Neurosurg Focus. 2004 Apr 15;16(4):E7
references: 15191336
references: Pituitary. 2011 Dec;14(4):400-4
references: 19655257
references: Clin Cancer Res. 2004 Mar 15;10(6):1871-4
references: 15041700
references: Cancer Invest. 2013 Mar;31(3):190-6
references: 23477586
references: N Engl J Med. 2005 Mar 10;352(10):997-1003
references: 15758010
references: Carcinogenesis. 1986 May;7(5):745-9
references: 3698202
references: Clin Endocrinol (Oxf). 2012 Jun;76(6):877-86
references: 22372583
references: Cancer Res. 2002 Jun 1;62(11):3070-6
references: 12036916
references: Clinics (Sao Paulo). 2012;67 Suppl 1:119-23
references: 22584716
references: Nat Rev Cancer. 2004 Apr;4(4):296-307
references: 15057289
references: World J Surg Oncol. 2007 Aug 04;5:89
references: 17683572
references: J Child Neurol. 2008 Dec;23(12):1467-71
references: 19073854
references: Neurosurgery. 2009 Apr;64(4):E773-4; discussion E774
references: 19349807
references: Lancet Oncol. 2006 Jun;7(6):518-20
references: 16750503
references: J Clin Oncol. 2006 Jan 20;24(3):401-6
references: 16421420
references: Curr Opin Oncol. 2003 Nov;15(6):412-8
references: 14624222
references: Mol Cancer Ther. 2004 Sep;3(9):1127-35
references: 15367707
references: Hormones (Athens). 2011 Apr-Jun;10(2):162-7
references: 21724542
references: J Clin Endocrinol Metab. 2010 Nov;95(11):E280-90
references: 20668043
references: Ann Endocrinol (Paris). 2012 Jun;73(3):225-9
references: 22520146
references: Mol Cell. 2004 Apr 9;14(1):105-16
references: 15068807
references: Cancer. 2009 Mar 1;115(5):1070-80
references: 19156926
references: Proc Natl Acad Sci U S A. 1985 May;82(9):2985-9
references: 3857628
references: Int J Cancer. 2005 Jan 20;113(3):379-85
references: 15455350
references: Cancer Res. 1996 Dec 1;56(23):5375-9
references: 8968088
references: N Engl J Med. 2005 May 5;352(18):1851-60
references: 15872200
references: Cancer Res. 1997 Sep 15;57(18):3949-55
references: 9307278
references: Eur J Endocrinol. 2009 Oct;161(4):631-7
references: 19654234
references: Nature. 1980 Dec 25;288(5792):727-9
references: 7005689
references: Endocr Pathol. 2007 Winter;18(4):217-22
references: 18026859
references: J Clin Oncol. 2007 Apr 20;25(12):1470-5
references: 17442989
references: J Clin Endocrinol Metab. 2010 Oct;95(10):4592-9
references: 20660056
references: Clin Endocrinol (Oxf). 2006 Oct;65(4):552-3
references: 16984254
references: Clin Cancer Res. 2006 Jan 15;12(2):328-31
references: 16428468
references: Cancer Res. 2006 Apr 15;66(8):3987-91
references: 16618716
references: Mutat Res. 2000 Apr;462(2-3):83-100
references: 10767620
references: Annu Rev Biochem. 1988;57:133-57
references: 3052269
references: Clin Endocrinol (Oxf). 2009 Apr;70(4):656-7
references: 18771563
references: J Neurosurg. 2006 Oct;105(4):621-6
references: 17044568
references: Oncol Rep. 2005 Nov;14(5):1275-80
references: 16211296
references: Pituitary. 1998 Apr;1(1):69-81
references: 11081185
references: N Engl J Med. 2006 Jun 29;354(26):2751-63
references: 16807412
references: Curr Opin Oncol. 2007 Nov;19(6):606-11
references: 17906460
references: Can J Neurol Sci. 2012 Sep;39(5):683-5
references: 23066557
references: Mutat Res. 1985 Jan-Mar;145(1-2):1-16
references: 3883145
references: Pituitary. 2007;10(1):81-6
references: 17285366
references: Hematol Oncol Clin North Am. 1995 Apr;9(2):431-50
references: 7642472
references: Pituitary. 2013 Dec;16(4):515-22
references: 23184261
references: Clin Cancer Res. 2007 Apr 1;13(7):2038-45
references: 17404084
references: Hormones (Athens). 2009 Oct-Dec;8(4):303-6
references: 20045804
references: Pituitary. 2011 Mar;14(1):80-91
references: 20972839
references: Pituitary. 2012 Mar;15(1):37-43
references: 21858654
references: Pituitary. 2012 Sep;15(3):276-87
references: 22076588
references: Acta Neuropathol. 2008 Feb;115(2):261-2
references: 17926052
references: Clin Endocrinol (Oxf). 2009 Aug;71(2):226-33
references: 19067722
references: Eur J Endocrinol. 2010 Dec;163(6):843-51
references: 20870708
references: Eur J Endocrinol. 2009 Oct;161(4):553-9
references: 19589911