title: Effects of organic apricot on liver regeneration after partial hepatectomy in rats.
abstract: BACKGROUND
  The present study investigated the effects of (sun-dried organic apricot/SDOA) supplementation in chow on liver regeneration after partial hepatectomy/(PH) in rats.
  
  
  METHODS
  In this study, 28 female rats were randomized into four groups. On the 7th day of the study, group 1 underwent laparoscopic intervention while a PH was performed on the other three cohorts. On day 28, all rats were humanely killed. Blood and liver tissue samples were subjected to biochemical determinations, histological examinations, and measurement of tissue oxidative stress enzyme activity.
  
  
  RESULTS
  Serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP), and liver tissue glutathione (GSH) activities were affected by PH and/or SDOA consumption (P < .05). Moderately staining cell counts in group 4 were significantly different from the other three groups (P < .05). However, no significant differences were detected among all groups in regard to aspartate aminotransferase (AST) serum levels or liver tissue superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) or glutathione peroxidase (GSHpx) activities (P < .05).
  
  
  CONCLUSIONS
  The 5% SDOA supplementation over a 21-day feeding period showed a beneficial effect on liver regeneration in rats, as reflects by Ki-67 finding although there was no change in ALT or ALP or in liver tissue GSH activity.
authors: Department of Pharmacology, İnonu University, Malatya/Turkey. yilmaz.ismet@inonu.edu.tr
authors: İ
authors: İ
authors: Yilmaz
authors: A
authors: A
authors: Karaman
authors: N
authors: N
authors: Vardi
authors: A
authors: A
authors: Cetin
authors: E
authors: E
authors: Erdemli
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D005638:Fruit; D006498:Hepatectomy / Q000379:methods*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects*; D023421:Models, Animal; D058871:Organic Agriculture; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D027861:Prunus; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D015415:Biomarkers; D010936:Plant Extracts