title: Protective effect of serofendic acid, administered intravenously, on cerebral ischemia-reperfusion injury in rats.
abstract: Serofendic acid is a low-molecular-weight compound extracted from fetal calf serum. We previously reported that intracerebroventricular administration of serofendic acid prevents cerebral ischemia-reperfusion injury. However, the effect of peripheral administration of serofendic acid on cerebral ischemia-reperfusion injury has not been examined. In the present study, we investigated the effect of intravenous administration of serofendic acid against cerebral ischemia-reperfusion injury using transient middle cerebral artery occlusion model rats. Serofendic acid (10mg/kg) administrated three times, including 30min before the onset of ischemia, just after the onset of ischemia and just before reperfusion reduced the infarct volume and improved the neurological dysfunction induced by ischemia-reperfusion without affecting regional cerebral blood flow or physiological parameters. However, there were no protective effects when serofendic acid (30mg/kg) was only administered once at 30min before the onset of ischemia, just after the onset of ischemia, or just before reperfusion. Our results reveal the importance of maintaining the blood concentration of serofendic acid for preventing cerebral ischemia-reperfusion injury.
authors: Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
authors: Tadaaki
authors: T
authors: Ioroi
authors: Kazuya
authors: K
authors: Taguchi
authors: Yasuhiko
authors: Y
authors: Izumi
authors: Yuki
authors: Y
authors: Takada-Takatori
authors: Akinori
authors: A
authors: Akaike
authors: Toshiaki
authors: T
authors: Kume
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy*; D004224:Diterpenes / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D004224:Diterpenes; D018696:Neuroprotective Agents; C452642:serofendic acid
keywords: Ischemia-reperfusion injury; Middle cerebral artery occlusion; Neuroprotection; Serofendic acid; Stroke