title: An immunophenotypic and molecular diagnosis of composite hairy cell leukaemia and chronic lymphocytic leukaemia.
abstract: Hairy cell leukaemia (HCL) and chronic lymphocytic leukaemia (CLL) are distinct clinicopathological B cell chronic lymphoproliferative disorders (B-CLPD). Both diseases have characteristic immunophenotypic and molecular features. The co-existence of two B-CLPD is perhaps more common than previously thought but a composite HCL and CLL has been rarely documented. A case is reported in which the morphology, integrated with an extensive immunophenotyping panel, and incorporation of the recently described HCL-associated BRAF V600E mutation, enabled the prompt diagnosis of composite HCL and CLL thus allowing appropriate treatment selection. This case serves to highlight the benefit of a multidisciplinary approach to the diagnosis of bi-clonal B-CLPD.
authors: Department of Haematology, Central Pathology Laboratory, St. James's Hospital, Dublin 8, Ireland, sliptrot@stjames.ie.
authors: Stuart
authors: S
authors: Liptrot
authors: David
authors: D
authors: O' Brien
authors: Stephen E
authors: SE
authors: Langabeer
authors: Fiona
authors: F
authors: Quinn
authors: A Jill
authors: AJ
authors: Mackarel
authors: Patrick
authors: P
authors: Elder
authors: Elisabeth
authors: E
authors: Vandenberghe
authors: Patrick J
authors: PJ
authors: Hayden
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D007943:Leukemia, Hairy Cell / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D057089:Pathology, Molecular / Q000379:methods
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