title: Oxytocin effects on neural correlates of self-referential processing.
abstract: Oxytocin (OT) influences how humans process information about others. Whether OT affects the processing of information about oneself remains unknown. Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration. We found that OT vs. placebo treatment reduced the differential amplitudes of a fronto-central positivity at 220-280 ms (P2) during self- vs. valence-judgments. OT vs. placebo treatment tended to reduce the differential amplitude of a late positive potential at 520-1000 ms (LPP) during self-judgments but to increase the differential LPP amplitude during other-judgments. OT effects on the differential P2 and LPP amplitudes to self- vs. celebrity-judgments were positively correlated with a measure of interdependence of self-construals. Thus OT modulates the neural correlates of self-referential processing and this effect varies as a function of interdependence.
authors: Department of Psychology, Peking University, Beijing, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
authors: Yi
authors: Y
authors: Liu
authors: Feng
authors: F
authors: Sheng
authors: Kate A
authors: KA
authors: Woodcock
authors: Shihui
authors: S
authors: Han
mesh_terms: D000281:Administration, Intranasal; D000704:Analysis of Variance; D001931:Brain Mapping; D004311:Double-Blind Method; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects*; D006801:Humans; D007600:Judgment / Q000187:drug effects; D008297:Male; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012649:Self Concept; D012938:Social Perception; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin
keywords: ERP; Oxytocin; P2; Self-construal; Self-referential processing