title: A novel polyethylene glycol mediated lipid nanoemulsion as drug delivery carrier for paclitaxel.
abstract: A novel polyethylene glycol 400 (PEG400) mediated lipid nanoemulsion as drug-delivery carrier for paclitaxel (PTX) was successfully developed. The formulation comprised a PEG400 solution of the drug (25mg/mL) that would be mixed with commercially 20% lipid emulsion to form PTX-loaded nanoemulsion (1mg/mL) prior to use. This two-vial formulation of PTX-loaded lipid nanoemulsion (TPLE) could significantly reduce extraction of reticuloendothelial system (RES) organs and increase tumor uptake, and exhibited more potent antitumor efficacy on bearing A2780 or Bcap-37 tumor nude mice compared to conventional PTX-loaded lipid nanoemulsion (CPLE). TPLE did not cause haematolysis and intravenous irritation response yet, and showed the same cytotoxicity against HeLa cells as Taxol®, and its LD50 was 2.7-fold higher than that of Taxol®, suggesting its good safety and druggability. In addition, TPLE displayed distinctly faster release of PTX, a greater proportion of PTX in phospholipids layer and a smaller share in oil phase than CPLE. From the Clinical Editor: This study demonstrates the feasibility and potential advantage of a novel PEG400-mediated two-vial formulation of lipid nanoemulsion as drug carrier for PTX in clinical application for the cancer therapy.
  
  
  BACKGROUND
  This team of investigators convincingly demonstrates the feasibility and potential advantage of a PEG400-mediated two-vial formulation of lipid nanoemulsion as drug carrier for PTX in cancer therapy, documenting superior safety and faster release of PTX compared to commercially available formulations.
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian, PR China.
authors: Xiaolong
authors: X
authors: Jing
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors: Li
authors: L
authors: Deng
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors: Baoan
authors: B
authors: Gao
authors: Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China.
authors: Lin
authors: L
authors: Xiao
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors: Yingying
authors: Y
authors: Zhang
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian, PR China.
authors: Xingfa
authors: X
authors: Ke
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian, PR China.
authors: Jianhao
authors: J
authors: Lian
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian, PR China.
authors: Qiang
authors: Q
authors: Zhao
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors: Lulu
authors: L
authors: Ma
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China. Electronic address: yaojz@sh163.net.
authors: Jianzhong
authors: J
authors: Yao
authors: School of Pharmacy, Second Military Medical University, Shanghai, PR China; Tasly Pharmaceutical Group Co., Ltd, Tianjin, PR China. Electronic address: yjcjm@163.com.
authors: Jianming
authors: J
authors: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D050997:Nanomedicine; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000628:therapy; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D011092:Polyethylene Glycols; D017239:Paclitaxel
keywords: Drug carrier; Lipid emulsion; Paclitaxel; Poorly water-soluble drug; Tumor