title: Is hydrogen cyanide a marker of Burkholderia cepacia complex?
abstract: Biofilm cultures of Burkholderia cepacia complex (BCC) infection have been found to generate the nonvolatile cyanide ion. We investigated if gaseous hydrogen cyanide (HCN) was a marker of BCC infection. Selected ion flow tube mass spectrometry analysis showed HCN was not elevated in the headspace of planktonic or biofilm cultures or in the exhaled breath of adult cystic fibrosis patients with chronic BCC infection. HCN is therefore not an in vitro or in vivo marker of BCC.
authors: Academic Department of Child Health, University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom.
authors: Francis J
authors: FJ
authors: Gilchrist
authors: Hayley
authors: H
authors: Sims
authors: Alice
authors: A
authors: Alcock
authors: Andrew M
authors: AM
authors: Jones
authors: Rowland J
authors: RJ
authors: Bright-Thomas
authors: David
authors: D
authors: Smith
authors: Patrik
authors: P
authors: Španel
authors: A Kevin
authors: AK
authors: Webb
authors: Warren
authors: W
authors: Lenney
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D001944:Breath Tests / Q000379:methods; D019121:Burkholderia Infections / Q000175:diagnosis* / Q000382:microbiology*; D042602:Burkholderia cepacia complex / Q000737:chemistry* / Q000302:isolation & purification*; D003550:Cystic Fibrosis / Q000150:complications; D005260:Female; D006801:Humans; D006856:Hydrogen Cyanide / Q000032:analysis*; D008297:Male; D013058:Mass Spectrometry
chemical_list: D015415:Biomarkers; D006856:Hydrogen Cyanide
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