title: Treatment of intrabony defects with anorganic bone matrix/p-15 or guided tissue regeneration in patients with aggressive periodontitis.
abstract: Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients were randomly allocated to be treated with ABM/P-15 or GTR. At baseline and at 3 and 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. There was a significant probing pocket depth reduction (p<0.001) for both groups (2.27 ± 0.96 mm for ABM/P-15 group and 2.57 ± 1.06 mm for GTR group). Clinical attachment level gain (1.87 ± 0.94 mm for ABM/P-15 group and 2.09 ± 0.88 mm for GTR group) was also observed. There were no statistically significant differences in clinical parameters between the groups. The radiographic bone fill was more expressive in ABM/P-15 group (2.49 mm) than in GTR group (0.73 mm). In subtraction radiographs, the areas representing gain in density were 93.16% of the baseline defect for ABM/P-15 group versus 62.03% in GRT group. There were no statistically significant differences in inter-group and intra-group comparisons with regards to IL-1β and IL-6 quantification. Treatment of intrabony periodontal defects in patients with G-AgP with ABM/P-15 and GTR improved significantly the clinical outcomes. The use of ABM/P-15 promoted a better radiographic bone fill.
authors: Dental School, Federal University of Amazonas, Manaus, AM, Brazil.
authors: Adriana C
authors: AC
authors: Queiroz
authors: Priscila Brasil da
authors: PB
authors: Nóbrega
authors: Fabíola S
authors: FS
authors: Oliveira
authors: Arthur B
authors: AB
authors: Novaes
authors: Mário
authors: M
authors: Taba
authors: Daniela B
authors: DB
authors: Palioto
authors: Márcio F M
authors: MF
authors: Grisi
authors: Sergio L S
authors: SL
authors: Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000601:surgery*; D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000637:transplantation*; D003094:Collagen / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008567:Membranes, Artificial; D010446:Peptide Fragments / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011859:Radiography; D013382:Subtraction Technique; D013524:Surgical Flaps / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D008567:Membranes, Artificial; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen