title: Stereocontrolled synthesis of 1,3-diols from enones: cooperative Lewis base-mediated intramolecular carbonyl hydrosilylations.
abstract: A streamlined synthesis of β-hydroxy ketone substrates has been developed to further investigate a recently discovered cooperative Lewis base-mediated intramolecular carbonyl hydrosilylation reaction. The synthesis features an enone β-borylation/oxidation sequence that has proven to be quite general and high-yielding. This has allowed for additional investigations into the diastereoselectivity of the hydrosilylation reaction through the preparation of important polyketide fragments.
authors: Department of Chemistry, Western Washington University , Bellingham, Washington 98225, United States.
authors: Casey
authors: C
authors: Medina
authors: Kyle P
authors: KP
authors: Carter
authors: Michael
authors: M
authors: Miller
authors: Timothy B
authors: TB
authors: Clark
authors: Gregory W
authors: GW
authors: O'Neil
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D058115:Lewis Bases; D012821:Silanes