title: The effect of topical doxycycline on corneal neovascularization.
abstract: OBJECTIVE
  To examine the effect of topical doxycycline on human corneal neovascularization (CONV).
  
  
  METHODS
  Six eyes of six patients with CONV received topical 1% doxycycline four times per day for three weeks and monitored for a total of one year. Ophthalmic evaluations included visual acuity, tonometry, slit-lamp examination, conjunctival swabs, quantification of CONV and photography.
  
  
  RESULTS
  CONV either disappeared or was attenuated, shortened and less dense in five of six patients. There were no adverse effects.
  
  
  CONCLUSIONS
  Topical doxycycline was effective in reducing CONV and healing of the ocular surface.
authors: Faculty of Medical Dentistry, University of Belgrade , Dr Subotica 8, Belgarde , Serbia.
authors: Vesna
authors: V
authors: Jovanovic
authors: Ljubisa
authors: L
authors: Nikolic
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016510:Corneal Neovascularization / Q000188:drug therapy*; D004318:Doxycycline / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010781:Photography; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D004318:Doxycycline