title: Ocular adnexal non-Hodgkin's lymphoma: a review of epidemiology and risk factors.
abstract: Ocular adnexal non-Hodgkin's lymphoma (NHL), the most common form of ophthalmic NHL, has a unique incidence pattern showing a steady and rapid increase in the past few decades, nearly equal rates among both genders, and predominance among Asians/Pacific Islanders. No major cause for ocular adnexal NHL has been identified, although infectious agents, immune disorders and genetic/epigenetic factors have all been implicated in its etiology. Identifying putative risk factors and biologic mechanisms leading to carcinogenesis in ocular adnexal NHL may enable implementation of effective preventive and/or therapeutic approaches for this malignancy. This article summarizes current knowledge on epidemiology of ocular adnexal NHL and the role of various potential risk factors in its etiology.
authors: Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, NY, USA ; Cancer Research Center, State University of New York at Albany, NY, USA.
authors: Roxana
authors: R
authors: Moslehi
authors: Maria J
authors: MJ
authors: Schymura
authors: Seema
authors: S
authors: Nayak
authors: F Bruce
authors: FB
authors: Coles
keywords: epigenetic changes and NHL; extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue; genetic factors and NHL; immune factors and NHL; infectious agents and NHL; ocular adnexal non-Hodgkin’s lymphoma
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