title: Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
abstract: The atypical cadherins Fat (Ft) and Dachsous (Ds) control tissue growth through the Salvador-Warts-Hippo (SWH) pathway, and also regulate planar cell polarity and morphogenesis. Ft and Ds engage in reciprocal signalling as both proteins can serve as receptor and ligand for each other. The intracellular domains (ICDs) of Ft and Ds regulate the activity of the key SWH pathway transcriptional co-activator protein Yorkie (Yki). Signalling from the FtICD is well characterized and controls tissue growth by regulating the abundance of the Yki-repressive kinase Warts (Wts). Here we identify two regulators of the Drosophila melanogaster SWH pathway that function downstream of the DsICD: the WD40 repeat protein Riquiqui (Riq) and the DYRK-family kinase Minibrain (Mnb). Ds physically interacts with Riq, which binds to both Mnb and Wts. Riq and Mnb promote Yki-dependent tissue growth by stimulating phosphorylation-dependent inhibition of Wts. Thus, we describe a previously unknown branch of the SWH pathway that controls tissue growth downstream of Ds.
authors: 1] Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia [2] Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.
authors: Joffrey L
authors: JL
authors: Degoutin
authors: Claire C
authors: CC
authors: Milton
authors: Eefang
authors: E
authors: Yu
authors: Marla
authors: M
authors: Tipping
authors: Floris
authors: F
authors: Bosveld
authors: Liu
authors: L
authors: Yang
authors: Yohanns
authors: Y
authors: Bellaiche
authors: Alexey
authors: A
authors: Veraksa
authors: Kieran F
authors: KF
authors: Harvey
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism*; D002478:Cells, Cultured; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000097603:Dyrk Kinases; D000099317:Hippo Kinases
chemical_list: D015820:Cadherins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; C094449:ds protein, Drosophila; C585064:wap protein, Drosophila; C092066:mnb protein, Drosophila; D000097603:Dyrk Kinases; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases
references: Curr Biol. 2006 Nov 7;16(21):2081-9
references: 16996266
references: Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14897-902
references: 18809931
references: Development. 2011 Jan;138(1):9-22
references: 21138973
references: Curr Biol. 2010 Apr 13;20(7):573-81
references: 20362447
references: Curr Biol. 2006 Nov 7;16(21):2101-10
references: 17045801
references: Development. 2006 Jun;133(12):2315-24
references: 16687445
references: Development. 2006 Nov;133(22):4561-72
references: 17075008
references: Curr Biol. 2010 May 11;20(9):803-10
references: 20434337
references: Dev Cell. 2011 Nov 15;21(5):896-906
references: 22075148
references: Dev Cell. 2010 Feb 16;18(2):300-8
references: 20159599
references: Cell. 2003 Aug 22;114(4):457-67
references: 12941274
references: Curr Opin Cell Biol. 2009 Dec;21(6):837-43
references: 19846288
references: Science. 2008 Jul 18;321(5887):401-4
references: 18635802
references: Development. 2008 Sep;135(17):2827-38
references: 18697904
references: Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15810-5
references: 20798049
references: FEBS J. 2006 Sep;273(18):4264-76
references: 16930133
references: EMBO J. 2010 Nov 17;29(22):3750-61
references: 20940704
references: J Biol Chem. 2004 Jan 23;279(4):2490-8
references: 14593110
references: Nat Cell Biol. 2006 Jan;8(1):27-36
references: 16341207
references: Curr Opin Cell Biol. 2009 Oct;21(5):717-23
references: 19679459
references: Nat Rev Cancer. 2007 Mar;7(3):182-91
references: 17318211
references: Nat Cell Biol. 2003 Oct;5(10):921-7
references: 14502295
references: Science. 2012 May 11;336(6082):724-7
references: 22499807
references: Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10532-7
references: 20498073
references: Curr Biol. 2006 Nov 7;16(21):2090-100
references: 16996265
references: Fly (Austin). 2008 Jul-Aug;2(4):229-35
references: 18719405
references: BMC Dev Biol. 2006 Jun 07;6:28
references: 16759393
references: Nat Genet. 2006 Oct;38(10):1142-50
references: 16980976
references: Curr Biol. 2012 Sep 11;22(17):1587-94
references: 22840515
references: Dev Cell. 2011 Nov 15;21(5):888-95
references: 22075147
references: J Cell Biol. 2008 Feb 25;180(4):691-6
references: 18299344
references: Dev Dyn. 2012 Jan;241(1):27-39
references: 21919123
references: Curr Biol. 2008 Sep 23;18(18):1390-5
references: 18804377
references: Dev Biol. 2007 May 1;305(1):187-201
references: 17359963
references: Development. 2012 Apr;139(8):1498-508
references: 22399682
references: Curr Biol. 2010 May 11;20(9):811-7
references: 20434335
references: Cell. 2007 Sep 21;130(6):1120-33
references: 17889654
references: Genes Dev. 1995 Jun 15;9(12):1530-42
references: 7601355
references: Dev Cell. 2010 Feb 16;18(2):309-16
references: 20159600
references: Development. 2008 Mar;135(6):1081-8
references: 18256197
references: Neuron. 1995 Feb;14(2):287-301
references: 7857639
references: Dev Cell. 2010 Feb 16;18(2):288-99
references: 20159598
references: Curr Biol. 2010 Jul 13;20(13):R574-82
references: 20619814
references: Curr Biol. 2010 Apr 13;20(7):582-90
references: 20362445
references: Cell. 2005 Aug 12;122(3):421-34
references: 16096061
references: Dev Cell. 2008 Aug;15(2):309-21
references: 18694569
references: Nat Cell Biol. 2008 Dec;10(12):1379-82
references: 19043429
references: Cell. 2011 Apr 29;145(3):357-70
references: 21514639
references: Curr Biol. 2012 Sep 11;22(17):1582-6
references: 22840522
references: PLoS Biol. 2011 Jun;9(6):e1000624
references: 21666802
references: Development. 2010 Mar;137(5):735-43
references: 20110315