title: T cell transcriptional factors in allergic rhinitis and its association with clinical features.
abstract: BACKGROUND
  Th2 cells are crucially important in allergic disease and the possible involvement of Treg and Th17 cells has not been clearly identified.
  
  
  OBJECTIVE
  To identify the mRNA expression of T cell transcription factors in nasal mucosa in patients with allergic rhinitis (AR) and to reveal their correlations with clinical features.
  
  
  METHODS
  Eighteen patients with AR and 12 controls with turbinate hypertrophy were included. mRNA expression of the following transcriptional factors in nasal mucosa were measured by quantitative polymerase chain reaction; T-bet (Th1), GATA3 (Th2), retinoic acid-related orphan receptor C (RORC; Th17), and forkhead box P3 (Foxp3; Treg). mRNA expression was compared among groups and correlation between mRNA expression level and clinical features (rhinitis symptoms, eosinophil count, and IgE) were also investigated.
  
  
  RESULTS
  GATA3 and RORC were significantly increased and Foxp3 was significantly decreased in the AR group. Moderate-to-severe AR group also had increased expression of GATA3 and RORC than mild AR group, suggesting severity of AR influence expression of transcription factors. Correlation analysis showed that none of these transcription factors were associated with severity of clinical symptoms, eosinophil counts and skin prick test severity and that IgE level was significantly correlated with expression level of GATA3 and RORC, suggesting an association of IgE production with Th2 and Th17 cells.
  
  
  CONCLUSIONS
  Increased mRNA expression of GATA3 (Th2), increased expression of RORC and decreased expression of Foxp3 may be important in pathogenesis of AR. GATA3 and RORC may be closed related with IgE level.
authors: Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan 330-715, Korea.
authors: Ji-Hun
authors: JH
authors: Mo
authors: Young-Jun
authors: YJ
authors: Chung
authors: Ji Hye
authors: JH
authors: Kim
keywords: Allergic rhinitis; Forkhead box P3; GATA3; Retinoic acid-related orphan receptor C; T-bet; Transcription factor
references: J Exp Med. 2004 Jun 7;199(11):1567-75
references: 15173208
references: Clin Exp Immunol. 2001 Aug;125(2):177-83
references: 11529906
references: Allergy. 2010 Sep;65(9):1149-57
references: 20192943
references: J Allergy Clin Immunol. 2008 Sep;122(3):650-1.e2
references: 18602680
references: Allergol Int. 2008 Jun;57(2):121-34
references: 18427165
references: Inflamm Allergy Drug Targets. 2008 Dec;7(4):237-52
references: 19075789
references: Respir Med. 2003 Jun;97(6):726-33
references: 12814161
references: Cell. 2006 Sep 22;126(6):1121-33
references: 16990136
references: Nat Immunol. 2007 Sep;8(9):958-66
references: 17676043
references: Otolaryngol Head Neck Surg. 2009 Feb;140(2):197-201
references: 19201288
references: J Allergy Clin Immunol. 2009 Aug;124(2):342-8, 348.e1-5
references: 19577286
references: Clin Immunol. 2004 Nov;113(2):172-8
references: 15451474
references: J Immunol. 2000 Dec 1;165(11):6107-15
references: 11086043
references: J Exp Med. 2010 Oct 25;207(11):2479-91
references: 20921287
references: Allergy. 2009 Sep;64(9):1375-8
references: 19226302
references: Nature. 2008 Apr 10;452(7188):773-6
references: 18337720
references: J Allergy Clin Immunol. 2001 Sep;108(3):430-8
references: 11544464
references: Lancet. 2004 Feb 21;363(9409):608-15
references: 14987885
references: Int Arch Allergy Immunol. 2010;151(4):297-307
references: 19844129
references: Laryngoscope. 2007 May;117(5):876-80
references: 17473687