title: [A case of elderly-onset type 1 diabetes mellitus: negative for antiglutamic acid dehydrogenase antibody and positive insulinoma-associated tyrosine phosphatase-like protein-2 antibody].
abstract: An 83-year-old Japanese woman given a diagnosis of type 2 diabetes mellitus 3 years previously was hospitalized for markedly elevated plasma glucose (386 mg/dl) and glycated hemoglobin (9.3%) levels. Laboratory study results showed urinary connecting peptide immunoreactivity (CPR) concentrations of 8.9 μg/day and serum CPR levels <0.2 ng/ml before and 0.3 ng/ml 6 min after glucagon administration, indicating decreased insulin secretion. Although antiglutamic acid dehydrogenase (GAD) antibody levels were negative, insulinoma-associated tryrosine phosphatase-like protein-2 (IA-2) antibody levels were positive (50 U/ml), leading to a diagnosis of type 1 diabetes mellitus. Furthermore, human leukocyte antigen (HLA) typing revealed DRB1*0901, a diabetes-susceptibility gene. Intensive insulin therapy was initiated. This was a rare case of elderly-onset type 1 diabetes.
authors: Department of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital.
authors: Yuko
authors: Y
authors: Chiba
authors: Jeong
authors: J
authors: Ynie
authors: Yoshiyuki
authors: Y
authors: Kimbara
authors: Yoshiaki
authors: Y
authors: Tamura
authors: Seijiro
authors: S
authors: Mori
authors: Hideki
authors: H
authors: Ito
authors: Atsushi
authors: A
authors: Araki
mesh_terms: D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D005969:Glutamate Dehydrogenase / Q000276:immunology*; D006801:Humans; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005969:Glutamate Dehydrogenase; C516862:PTPRN protein, human; D054635:Receptor-Like Protein Tyrosine Phosphatases, Class 8