title: Liquid crystal-based molecularly imprinted nanoparticles with low crosslinking for capillary electrochromatography.
abstract: In this work, molecularly imprinted polymer (MIP) nanoparticles were prepared at a low level of crosslinking in the presence of liquid crystalline monomer as physical crosslinker to replace the most of chemical crosslinker. The imprinted nanoparticles against d-zopiclone were synthesized by precipitation polymerization using a mixture of methacrylic acid, ethylene glycol dimethacrylate, and liquid crystalline monomers. The resulting d-zopiclone imprinted nanoparticles were evaluated in capillary electrochromatography by partial filling technique. The resolution of enantiomer separation achieved on the d-zopiclone-imprinted nanoparticles was up to 3.29 and the column efficiency of zopiclone enantiomer (up to 66,900 plates/m) with good peak symmetry was obtained. The imprinted nanoparticles prepared in the presence of liquid crystalline monomer can retain affinity and specificity for template even when prepared with a level of cross-linker as low as 5%.
authors: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
authors: Xiao
authors: X
authors: Liu
authors: Hai-Yan
authors: HY
authors: Zong
authors: Yan-Ping
authors: YP
authors: Huang
authors: Zhao-Sheng
authors: ZS
authors: Liu
mesh_terms: D053801:Capillary Electrochromatography / Q000295:instrumentation*; D003432:Cross-Linking Reagents / Q000737:chemistry; D050866:Liquid Crystals / Q000737:chemistry*; D054802:Molecular Imprinting; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D011108:Polymers
keywords: Enantiomers separation; Liquid crystal; Low crosslinking; Molecularly imprinted polymer; Nanoparticles; Zopiclone