title: Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma.
abstract: Subacute cerebellar degeneration associated with metabotropic glutamate receptor type 1 (mGluR1) autoantibodies is an uncommon syndrome known to be part of the spectrum of paraneoplastic cerebellar degenerations associated with neuronal autoantibodies. We describe a patient with prostate adenocarcinoma who developed a subacute cerebellar ataxia. Autoantibodies specific to mGluR1 were detected in patient's serum and cerebrospinal fluid (CSF). Immunohistochemistry analyses of patient's prostate adenocarcinoma revealed abundant mGluR1 expression in luminal acinar epithelial cells and binding of patient's IgGs to tumoral mGluR1. These findings suggest that cerebellar degeneration associated with mGluR1 antibodies can be a paraneoplastic accompaniment of prostate adenocarcinoma.
authors: Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy. Electronic address: iorio.raffaele@gmail.com.
authors: Raffaele
authors: R
authors: Iorio
authors: Valentina
authors: V
authors: Damato
authors: Massimiliano
authors: M
authors: Mirabella
authors: Maria Gabriella
authors: MG
authors: Vita
authors: Esther
authors: E
authors: Hulsenboom
authors: Domenico
authors: D
authors: Plantone
authors: Alessandra
authors: A
authors: Bizzarro
authors: Alessandra
authors: A
authors: Del Grande
authors: Peter A E
authors: PA
authors: Sillevis Smitt
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D051379:Mice; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1
keywords: Antibodies; Metabotropic glutamate receptor 1; Paraneoplastic cerebellar degeneration