title: HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women.
abstract: As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P<0.05). One haplotype (CTGCGG) that was associated with breast cancer was found via haplotype analysis. Our research also indicated an association between polymorphisms of HVEM and clinicopathologic features, including lymph node metastasis, estrogen receptor, progesterone receptor and P53. Our results primarily indicate that polymorphisms of the HVEM gene were associated with the risk of sporadic breast cancer in northeast Chinese females.
authors: Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China ; Department of Immunology & Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University, Harbin, China.
authors: Dalin
authors: D
authors: Li
authors: Zhenkun
authors: Z
authors: Fu
authors: Shuang
authors: S
authors: Chen
authors: Weiguang
authors: W
authors: Yuan
authors: Yanhong
authors: Y
authors: Liu
authors: Liqun
authors: L
authors: Li
authors: Da
authors: D
authors: Pang
authors: Dianjun
authors: D
authors: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D001943:Breast Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D053240:Receptors, Tumor Necrosis Factor, Member 14; C506028:TNFRSF14 protein, human; D016159:Tumor Suppressor Protein p53
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