title: Organosulfur compounds and possible mechanism of garlic in cancer.
abstract: Garlic (Allium sativum), a member of the family Liliaceae, contains an abundance of chemical compounds that have been shown to possess beneficial effects to protect against several diseases, including cancer. Evidence supports the protective effects of garlic in stomach, colorectal, breast cancer in humans. The protective effects appear to be related to the presence of organosulfur compounds, predominantly allyl derivatives, which also have been shown to inhibit carcinogenesis in forestomach, esophagus, colon, mammary gland and lung of experimental animals. The exact mechanisms of the cancer-preventive effects are not clear, although several hypotheses have been proposed. Organosulfur compounds modulate the activity of several metabolizing enzymes that activate (cytochrome P450s) or detoxify (glutathione S-transferases) carcinogens and inhibit the formation of DNA adducts in several target tissues. Antiproliferative activity has been described in several tumor cell lines, which is possibly mediated by induction of apoptosis and alterations of the cell cycle. Organosulfur compounds in garlic are thus possible cancer-preventive agents. Clinical trials will be required to define the effective dose that has no toxicity in humans.
authors: College of Pharmacy, Al-Qassim University, P.O. Box 31922, Buraidah 51418, Saudi Arabia.
authors: S H
authors: SH
authors: Omar
authors: N A
authors: NA
authors: Al-Wabel
keywords: Antiproliferative; Antitumor; Antitumorigenic; Garlic; Organosulfur
references: Cancer Res. 2003 Oct 15;63(20):6825-37
references: 14583480
references: Carcinogenesis. 1996 Apr;17(4):669-73
references: 8625476
references: Am J Clin Nutr. 1997 Aug;66(2):398-405
references: 9250120
references: Cancer Lett. 1997 Sep 16;118(1):61-7
references: 9310261
references: Cancer Res. 1988 Dec 1;48(23):6872-5
references: 3180095
references: J Ocul Pharmacol. 1993 Fall;9(3):201-9
references: 8228529
references: J Biochem Mol Toxicol. 1999;13(3-4):127-34
references: 10098897
references: Nutr Cancer. 1997;27(2):186-91
references: 9121948
references: Mol Pharmacol. 1998 Mar;53(3):402-7
references: 9495804
references: Nutr Cancer. 1998;30(3):169-74
references: 9631486
references: Cancer Lett. 1997 May 19;115(2):129-33
references: 9149115
references: Chem Res Toxicol. 1997 Mar;10(3):318-27
references: 9084912
references: Med Res Rev. 1996 Jan;16(1):111-24
references: 8788216
references: Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22
references: 8367443
references: Biochim Biophys Acta. 2000 Jan 15;1463(1):20-30
references: 10631291
references: Adv Enzymol Relat Subj Biochem. 1951;11:377-400
references: 24540596
references: Biochim Biophys Acta. 1994 Mar 10;1221(1):73-7
references: 7510522
references: Cancer Res. 1989 Sep 15;49(18):5073-6
references: 2504484
references: J Nutr. 2001 Mar;131(3s):1032S-40S
references: 11238811
references: Planta Med. 1992 Aug;58(4):301-5
references: 1438588
references: Biochem Biophys Res Commun. 1996 Aug 14;225(2):660-5
references: 8753815
references: Nutr Cancer. 1986;8(3):211-5
references: 3737423
references: Carcinogenesis. 1987 Aug;8(8):1155-7
references: 3608098
references: Nutr Cancer. 1999;34(1):42-8
references: 10453440
references: Biochem Pharmacol. 1993 Jun 9;45(11):2323-9
references: 8390837
references: Planta Med. 1994 Oct;60(5):417-20
references: 7997468
references: Curr Cancer Drug Targets. 2003 Feb;3(1):67-81
references: 12570662
references: Cancer Lett. 1990 Feb;49(2):175-80
references: 2306712
references: Cancer Lett. 1992 Apr 30;63(3):211-9
references: 1349504
references: Res Commun Mol Pathol Pharmacol. 1998 Nov;102(2):163-74
references: 10100508
references: Antimicrob Agents Chemother. 1988 Dec;32(12):1763-8
references: 2469386
references: Experientia. 1996 Feb 15;52(2):115-20
references: 8608811
references: Drug Chem Toxicol. 1999 May;22(2):343-58
references: 10234471
references: Toxicol Appl Pharmacol. 1991 Apr;108(2):342-54
references: 2017758
references: Cancer Lett. 1992 Aug 31;65(3):227-32
references: 1516037
references: Carcinogenesis. 1993 Aug;14(8):1627-31
references: 8353846
references: Mutat Res. 1989 Dec;227(4):215-9
references: 2511444
references: Sci Am. 1985 Mar;252(3):114-9
references: 3975593
references: Nutrition. 1997 Jul-Aug;13(7-8):656-63
references: 9263259
references: Cancer Res. 1990 Aug 15;50(16):5084-7
references: 2379172
references: Nutr Rev. 1996 Nov;54(11 Pt 2):S82-6
references: 9110580
references: CA Cancer J Clin. 2005 May-Jun;55(3):178-94
references: 15890640
references: Cancer Lett. 2000 Nov 10;160(1):29-35
references: 11098081
references: Agents Actions. 1990 Mar;29(3-4):360-3
references: 2111084
references: Carcinogenesis. 1987 Mar;8(3):487-9
references: 3815744
references: Cancer Res. 1988 Nov 1;48(21):5937-40
references: 3167846
references: Bioessays. 2000 Nov;22(11):1007-17
references: 11056477
references: Am J Chin Med. 1998;26(3-4):353-64
references: 9862023
references: Oncology. 1993;50(1):63-9
references: 8421600
references: Am J Clin Nutr. 2000 Oct;72(4):1047-52
references: 11010950
references: Biochim Biophys Acta. 1998 Feb 2;1379(2):233-44
references: 9528659
references: Phytomedicine. 1999 Mar;6(1):7-11
references: 10228605
references: Nutr Cancer. 1996;25(3):241-8
references: 8771567
references: Carcinogenesis. 1988 Jan;9(1):131-4
references: 3335037
references: Nutr Cancer. 1997;29(2):152-6
references: 9427979
references: Environ Mol Mutagen. 1989;13(4):357-65
references: 2661224
references: Nutr Cancer. 1999;35(2):160-6
references: 10693170
references: Mycologia. 1977 Mar-Apr;69(2):341-8
references: 865503
references: Cancer Biochem Biophys. 1986 Oct;8(4):299-312
references: 3802049
references: Planta Med. 1991 Aug;57(4):371-5
references: 1775580
references: Exp Mol Med. 2000 Sep 30;32(3):127-34
references: 11048643
references: J Nutr. 1999 Jul;129(7 Suppl):1395S-7S
references: 10395605
references: Prostate. 2000 Dec 1;45(4):304-14
references: 11102955
references: Cancer Lett. 1993 Oct 15;74(1-2):85-90
references: 8287376
references: Nutr Cancer. 1997;27(2):177-85
references: 9121947
references: Cancer Lett. 1996 Apr 19;102(1-2):199-204
references: 8603370
references: Cancer Res. 1994 Jun 1;54(11):2895-9
references: 8187074
references: Planta Med. 1995 Aug;61(4):356-7
references: 7480182
references: Carcinogenesis. 1994 Feb;15(2):349-52
references: 8313528
references: Food Chem Toxicol. 1998 Sep-Oct;36(9-10):761-70
references: 9737423
references: Carcinogenesis. 2000 Jun;21(6):1129-34
references: 10837000