title: One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease.
abstract: Multiple sclerosis (MS) is an incurable inflammatory demyelinating disease. We investigated one calcitriol dose plus vitamin D3 (calcitriol/+D) as a demyelinating disease treatment in experimental autoimmune encephalomyelitis (EAE). Evidence that calcitriol-vitamin D receptor pathway deficits may promote MS, and data showing calcitriol enhancement of autoimmune T cell apoptosis provided the rationale. Whereas vitamin D3 alone was ineffective, calcitriol/+D transiently increased central nervous system (CNS) Helios(+)FoxP3(+) T cells and sustainably decreased CNS T cells, pathology, and neurological deficits in mice with EAE. Calcitriol/+D, which was more effective than methylprednisolone, has potential for reversing inflammatory demyelinating disease safely and cost-effectively.
authors: Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, United States.
authors: Faye E
authors: FE
authors: Nashold
authors: Corwin D
authors: CD
authors: Nelson
authors: Lauren M
authors: LM
authors: Brown
authors: Colleen E
authors: CE
authors: Hayes
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage*; D002417:Cattle; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis*; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D011897:Random Allocation; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis*; D015854:Up-Regulation / Q000187:drug effects / Q000276:immunology*
chemical_list: D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D014157:Transcription Factors; C491746:Zfpn1a2 protein, mouse; D002117:Calcitriol
keywords: Autoimmunity; Encephalomyelitis; Methylprednisolone; Multiple sclerosis; Vitamin D