title: Studies toward welwitindolinones: formal syntheses ofN-methylwelwitindolinone C isothiocyanate and related natural products.
abstract: The formal syntheses ofN-methylwelwitindolinone C isothiocyanate (4) and several other welwitindolinones5-8were achieved by the independent synthesis of79. The synthesis featured a Lewis acid-mediated coupling between a heteroaryl carbinol and bis-TMS enol ether, an intramolecular enolate arylation, and an unprecedented intramolecular allylic alkylation of a γ-acyloxyenone.
authors: Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, TX 78712-0165, USA.
authors: Tsung-Hao
authors: TH
authors: Fu
authors: William T
authors: WT
authors: McElroy
authors: Mariam
authors: M
authors: Shamszad
authors: Richard W
authors: RW
authors: Heidebrecht
authors: Brian
authors: B
authors: Gulledge
authors: Stephen F
authors: SF
authors: Martin
keywords: Alkaloids; Allylic alkylation; Enolate arylation; Lewis acid-mediated coupling; Welwitindolinones
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