title: [Influence of Hepatomax on male fertility].
abstract: The features of morphotype sperm in men with infertility and found some monomodal its deviations. The study of products of lipid peroxidation (LPO) and antioxidant enzymes (AOP) levels in men with mild forms of chronic inflammation of the urogenital tract complicated with infertility. The studies found that the majority of men surveyed marked activation of lipid peroxidation of biological membranes, which was accompanied by increased concentrations of the major metabolite of LPO--intermediate (conjugated diene) and final (malondialdehyde) in serum. In the study of the system of AOP was found that the activity of catalase and superoxide dismutase decreased. Was calculated as an integrative index F, which characterizes the ratio of prooxidant and antioxidant properties of blood. Found suppression of the index, which indicates an imbalance indicators LPO/AOP. A negative correlation between the index F and the presence of mikrosomatich form sperm was found. The positive influence of the Hepatomax on the process of recovery oxidative activity systems, normalization of the integral index of F and reduce the number of abnormal forms of generative cells was established. Given antioxidant, immunomodulating, hepatoprotective properties of the Hepatomax, we consider it appropriate to include this drug in treatment of infertile men with inflammatory processes in the urogenital tract.
authors: S Iu
authors: SIu
authors: Tsiporenko
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001688:Biological Products / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D060737:Reproductive Tract Infections / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012661:Semen / Q000187:drug effects* / Q000378:metabolism; D012838:Silymarin / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001688:Biological Products; D012838:Silymarin; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase