title: Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats.
abstract: Uremia means excess nitrogenous waste products in the blood & their toxic effects. An acute acetaminophen (paracetamol, N-acetyl p-aminophenol; APAP) overdose may result into potentially fatal hepatic and renal necrosis in humans and experimental animals. The aims of this present study were to investigate the protective effect of alpha-lipoic acid (ALA) on oxidative stress & uremia on male albino rats induced by acetaminophen. The study was performed by 24 albino male Wister strain rats which were randomly divided into four groups: Group I, control - receives normal food and water, Groups II, III & IV receive acetaminophen interperitoneally at the dose of 500 mg/kg/day for 10 days, from 11th day Groups III & IV were treated with ALA at the dose of 5 mg & 10 mg/100 g/day for 15 days, respectively. After 25 days of treatment, it was observed that there was a significant increase in plasma urea, creatinine, sodium and malondialdehyde (MDA) levels (p < 0.05) but a significant decrease in super oxide dismutase (SOD) & catalase activity & potassium level in uremic group is compared with control group & there was a significant increase in SOD & catalase (p < 0.05) & a significant decrease in serum urea, creatinine & Na and MDA (p < 0.05) in Group III & Group IV is compared with Group II & significant changes were observed in high ALA dose group. In conclusion it was observed that the ALA has nephroprotective activities by biochemical observations against acetaminophen induced uremic rats.
authors: Department of Nutrition, Microbiology and Human Physiology, Research Unit, Raja N.L. Khan Women's College, Midnapore 721 102, West Bengal, India.
authors: Shrabani
authors: S
authors: Pradhan
authors: Shreya
authors: S
authors: Mandal
authors: Suchismita
authors: S
authors: Roy
authors: Arpita
authors: A
authors: Mandal
authors: Koushik
authors: K
authors: Das
authors: Dilip K
authors: DK
authors: Nandi
keywords: Acetaminophen; Alpha-lipoic acid (ALA); Oxidative stress; Uremia
references: Ren Fail. 2004 Sep;26(5):517-24
references: 15526909
references: Toxicology. 2002 Aug 15;177(2-3):187-96
references: 12135622
references: Saudi J Kidney Dis Transpl. 2010 Jan;21(1):75-80
references: 20061697
references: Free Radic Biol Med. 1995 Aug;19(2):227-50
references: 7649494
references: Eur J Biochem. 1993 Jul 15;215(2):213-9
references: 7688300
references: Nihon Juigaku Zasshi. 1990 Feb;52(1):113-9
references: 2313944
references: Eur J Biochem. 1974 Sep 16;47(3):469-74
references: 4215654
references: Pharmacol Toxicol. 2000 May;86(5):234-41
references: 10862506
references: J Clin Pharm Ther. 1993 Feb;18(1):5-8
references: 8473360
references: Toxicology. 2007 May 5;234(1-2):124-34
references: 17391827
references: J Biol Chem. 1952 Mar;195(1):133-40
references: 14938361
references: Iran J Pharm Res. 2010 Spring;9(2):153-61
references: 24363722
references: Nephrol Dial Transplant. 2005 Dec;20(12):2587-93
references: 16204281
references: Exp Toxicol Pathol. 2008 Aug;60(4-5):289-94
references: 18407480
references: Metabolism. 1992 Nov;41(11):1229-32
references: 1435296
references: J Clin Chem Clin Biochem. 1988 Jan;26(1):15-24
references: 3373146
references: J Infect Dis. 1982 Mar;145(3):370-3
references: 7061883
references: IUBMB Life. 2008 Jun;60(6):362-7
references: 18409172
references: Clin Chem. 1959 Jun;5(3):171-85
references: 13663271
references: Curr Med Chem. 2004 May;11(9):1135-46
references: 15134511
references: Anal Biochem. 1979 Jun;95(2):351-8
references: 36810
references: Semin Nephrol. 2004 Sep;24(5):469-73
references: 15490413
references: Cell Mol Biol Lett. 2003;8(2):461-70
references: 12813579