title: Genetic disorders of potassium homeostasis.
abstract: Hereditary disorders of potassium homeostasis are an interesting group of disorders, affecting people from the newborn period to adults of all ages. The clinical presentation varies from severe hypotension at birth to uncontrolled hypertension in adults, often associated with abnormal potassium values, although many patients may have a normal serum potassium concentration despite being affected by the genetic disorder. A basic understanding of these disorders and their underlying mechanisms has significant clinical implications, especially in the few patients with subtle clinical signs and symptoms. We present a summary of these disorders, with emphasis on the clinical presentation and genetic mechanisms of these disorders.
authors: Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors: Gaurav
authors: G
authors: Jain
authors: Song
authors: S
authors: Ong
authors: David G
authors: DG
authors: Warnock
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D001477:Bartter Syndrome / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D053579:Gitelman Syndrome / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006947:Hyperkalemia / Q000235:genetics*; D006994:Hypoaldosteronism / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D007008:Hypokalemia / Q000235:genetics*; D056929:Liddle Syndrome / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D043204:Mineralocorticoid Excess Syndrome, Apparent / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D011188:Potassium / Q000378:metabolism*; D011546:Pseudohypoaldosteronism / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
chemical_list: D011188:Potassium
keywords: Bartter; Genetic disorders of potassium; Gitelman; Liddle; aldosteronism