title: Canine transmissible venereal tumour: a review.
abstract: Canine transmissible venereal tumour (CTVT) is a contagious venereal tumour of dogs, commonly observed in dogs that are in close contact with one another, or in stray and wild dogs that exhibit unrestrained sexual activity. CTVT represents a unique, naturally transmissible, contagious tumour, where the mutated tumour cell itself is the causative agent and perpetuates as a parasitic allograft in the host. Clinical history, signalment and cytological features are often obvious for establishing a diagnosis though biopsy and histological examination may be needed in atypical cases. Most cases are curable with three intravenous injections of vincristine sulphate at weekly intervals. The role of stray and wild dogs makes the disease difficult to control and necessitates sustained animal birth control in stray dogs along with prompt therapy of the affected dogs. This review captures the manifold developments in different areas embracing this fascinating tumour, including its biology, diagnosis and therapeutic alternatives.
authors: Animal Biotechnology Center, Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, India.
authors: B
authors: B
authors: Ganguly
authors: Broad Street Pet Clinics, Kolkata, India.
authors: U
authors: U
authors: Das
authors: Department of Surgery and Radiology, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, India.
authors: A K
authors: AK
authors: Das
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D014685:Venereal Tumors, Veterinary / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents
keywords: canine; diagnosis; immunity; transmissible venereal tumour; treatment