title: The effect of surgical wide excision and amniotic membrane transplantation with adjuvant topical mitomycin C treatment in recurrent conjunctival--corneal intraepithelial neoplasia.
abstract: OBJECTIVE
  To investigate the effect of surgical wide excision and amniotic membrane transplantation with adjuvant mitomycin C 0.04% eye drops on recurrent conjunctival-corneal intraepithelial neoplasia (CCIN).
  
  
  METHODS
  The authors applied amniotic membrane transplantation after total surgical excision of a tumor to a patient with recurrent conjunctival-corneal intraepithelial neoplasia. The tumor co-existed as a conjunctival lesion and corneal opacity. After one week, the patient received mitomycin C 0.04% eye drops four times a day for one month to prevent recurrence. Ocular complications and recurrence were evaluated under slit lamp microscopy for one year.
  
  
  RESULTS
  Corneal epithelium completely healed within one week after the surgery. Both conjunctival and corneal lesions were completely regressed and no recurrence has been found with follow-up to 24 months.
  
  
  CONCLUSIONS
  Surgical wide excision and amniotic membrane transplantation with adjuvant topical MMC would be an effective treatment modality for treatment of recurrent CCIN.
authors: Department of Ophthalmology & Visual Science, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors: Jae Hyung
authors: JH
authors: Lee
authors: Yeong Hoon
authors: YH
authors: Kim
authors: Man Soo
authors: MS
authors: Kim
authors: Eun Chul
authors: EC
authors: Kim
mesh_terms: D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D000650:Amnion / Q000637:transplantation*; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003230:Conjunctival Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003316:Corneal Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D013508:Ophthalmologic Surgical Procedures
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin
keywords: Aamniotic membrane transplantation; corneal opacity; recurrent conjunctival–corneal intraepithelial neoplasia (CCIN); surgical wide excision; topical mitomycin C