title: Environmental epigenetics and effects on male fertility.
abstract: Environmental exposures to factors such as toxicants or nutrition can have impacts on testis biology and male fertility. The ability of these factors to influence epigenetic mechanisms in early life exposures or from ancestral exposures will be reviewed. A growing number of examples suggest environmental epigenetics will be a critical factor to consider in male reproduction.
authors: Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, 99164-4236, USA.
authors: Carlos
authors: C
authors: Guerrero-Bosagna
authors: Michael K
authors: MK
authors: Skinner
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000633:toxicity; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000235:genetics; D013737:Testis / Q000187:drug effects / Q000196:embryology
chemical_list: D004785:Environmental Pollutants
references: Trends Endocrinol Metab. 2010 Apr;21(4):214-22
references: 20074974
references: Lancet. 2004 May 22;363(9422):1700-2
references: 15158633
references: Fertil Steril. 2012 Feb;97(2):267-74
references: 22289286
references: Reprod Domest Anim. 2008 Jul;43 Suppl 2:310-6
references: 18638140
references: Bioessays. 1991 Apr;13(4):151-6
references: 1859392
references: Mol Cell Endocrinol. 2000 May 25;163(1-2):3-9
references: 10963867
references: Pediatr Res. 2013 Apr;73(4 Pt 2):523-30
references: 23314296
references: Genes Dev. 2000 Oct 15;14(20):2587-95
references: 11040213
references: Science. 2012 Sep 28;337(6102):1614-5
references: 23019638
references: Mod Pathol. 2013 Apr;26(4):465-84
references: 23307060
references: Asian J Androl. 2012 Jan;14(1):164-71
references: 22179516
references: J Steroid Biochem. 1990 Feb;35(2):173-8
references: 2308334
references: Arch Anat Microsc Morphol Exp. 1980;69(4):297-318
references: 7212698
references: BMC Mol Biol. 2008 Apr 29;9:44
references: 18445271
references: PLoS Genet. 2011 Jun;7(6):e1001391
references: 21695223
references: Toxicology. 2013 Nov 8;313(1):3-14
references: 23238276
references: J Biochem. 2005 Jul;138(1):13-9
references: 16046443
references: Psicothema. 2013 Feb;25(1):3-12
references: 23336536
references: Dev Biol. 1998 Nov 15;203(2):323-33
references: 9808783
references: J Appl Toxicol. 2012 Sep;32(9):643-53
references: 22334439
references: Cell Mol Life Sci. 2012 Dec;69(24):4177-90
references: 22802127
references: Dev Dyn. 2001 Apr;220(4):363-76
references: 11307169
references: Epigenetics. 2011 Jul;6(7):838-42
references: 21637037
references: Mol Endocrinol. 2008 Jan;22(1):1-9
references: 17666585
references: Int J Dev Biol. 1993 Sep;37(3):407-15
references: 8292535
references: Life Sci. 2009 Nov 18;85(21-22):742-52
references: 19837096
references: Hum Reprod. 2001 May;16(5):972-8
references: 11331648
references: Bioessays. 2007 Jan;29(1):15-25
references: 17187356
references: Nature. 2007 Aug 9;448(7154):714-7
references: 17687327
references: Fertil Steril. 2013 Mar 1;99(3):607-15
references: 23357459
references: Cytogenet Genome Res. 2003;101(3-4):219-23
references: 14684986
references: Biol Reprod. 2009 Jun;80(6):1178-88
references: 19211811
references: Int J Androl. 2010 Aug 1;33(4):642-9
references: 19878521
references: Curr Biol. 2007 Feb 20;17(4):379-84
references: 17239600
references: Int J Androl. 2007 Aug;30(4):198-204; discussion 204-5
references: 17705804
references: Mol Cell Biol. 2001 Dec;21(23):8197-202
references: 11689708
references: Endocr Rev. 1991 Feb;12(1):45-77
references: 2026122
references: Gastric Cancer. 2007;10(2):75-83
references: 17577615
references: Hum Reprod Update. 2011 May-Jun;17(3):418-33
references: 21266373
references: Genesis. 2002 Aug;33(4):170-80
references: 12203914
references: Nat Commun. 2012;3:1053
references: 22968699
references: Hum Reprod. 2009 Sep;24(9):2361-4
references: 19477879
references: EXS. 2001;(91):11-24
references: 11301595
references: Oncogene. 2004 Aug 23;23(38):6329-40
references: 15322508
references: Reprod Toxicol. 2011 Apr;31(3):344-50
references: 20955784
references: Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1697-712
references: 20403879
references: Cell Mol Life Sci. 2008 Oct;65(20):3182-95
references: 18581056
references: Semin Reprod Med. 2000;18(1):41-9
references: 11299518
references: J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):204-15
references: 21899826
references: Int Arch Occup Environ Health. 2004 Apr;77(3):153-8
references: 14963712
references: Cell. 2012 Sep 28;151(1):167-80
references: 23021223
references: Semin Reprod Med. 2009 Jan;27(1):5-13
references: 19197800
references: Reprod Toxicol. 2011 May;31(4):507-12
references: 21382472
references: PLoS One. 2010 Sep 30;5(9):
references: 20927350
references: Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11184-8
references: 16847261
references: Fertil Steril. 2010 Jul;94(2):585-94
references: 19338988
references: Aust Vet J. 1990 Jun;67(6):197-201
references: 2222361
references: Front Biosci (Elite Ed). 2012 Jan 01;4(2):746-54
references: 22201910
references: Development. 1993 Jan;117(1):273-81
references: 8223251
references: Best Pract Res Clin Endocrinol Metab. 2011 Apr;25(2):391-402
references: 21397206
references: Mol Cell Endocrinol. 2012 May 22;355(2):231-9
references: 22061620
references: Cell. 2010 Dec 23;143(7):1084-96
references: 21183072
references: Nature. 2008 Jun 12;453(7197):930-4
references: 18454134
references: Sex Dev. 2008;2(3):128-33
references: 18769072
references: PLoS One. 2013;8(1):e55387
references: 23359474
references: Cytogenet Cell Genet. 2000;91(1-4):72-80
references: 11173834
references: Hum Mol Genet. 2007 Nov 1;16(21):2542-51
references: 17636251
references: Lancet. 2011 Oct 22;378(9801):1461-84
references: 21924486
references: EXS. 2001;(91):97-115
references: 11301602
references: PLoS One. 2012;7(10):e47892
references: 23112866
references: Front Neuroendocrinol. 2008 Jun;29(3):386-97
references: 18462782
references: PLoS One. 2012;7(2):e31901
references: 22389676
references: Reprod Fertil Dev. 2011;23(3):403-16
references: 21426858
references: Epigenetics. 2008 Jan-Feb;3(1):5-13
references: 18259118
references: Endocrinology. 2006 Dec;147(12):5515-23
references: 16973726
references: Andrologia. 2002 Dec;34(6):384-90
references: 12472623
references: J Biol Chem. 2007 Apr 6;282(14):10553-60
references: 17277314
references: Biol Reprod. 2003 Jun;68(6):2033-7
references: 12606390
references: Science. 2001 Aug 10;293(5532):1089-93
references: 11498579
references: PLoS One. 2011;6(5):e19935
references: 21637323
references: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
references: 16877546
references: Epigenetics. 2013 Feb;8(2):192-202
references: 23314690
references: J Cell Biol. 2007 Jan 29;176(3):283-94
references: 17261847
references: Hum Genet. 1981;58(1):59-63
references: 7286994
references: PLoS One. 2011;6(11):e28282
references: 22140567
references: J Anim Sci. 1995 May;73(5):1509-15
references: 7665383
references: Int J Health Serv. 1991;21(4):731-57
references: 1769760
references: Dev Biol. 2004 Oct 15;274(2):271-9
references: 15385158
references: Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9143-8
references: 22615374
references: Sex Dev. 2012;6(1-3):7-17
references: 22025195
references: Andrologia. 2012 May;44 Suppl 1:187-93
references: 21592178
references: Endocrinology. 2011 Jun;152(6):2228-36
references: 21447631
references: Hum Ecol Interdiscip J. 2007;35(6):653-668
references: 32214603
references: Dev Biol. 2005 Feb 15;278(2):473-81
references: 15680364
references: Fertil Steril. 2010 Oct;94(5):1728-33
references: 19880108
references: Int J Androl. 2008 Sep;31(5):462-70
references: 18637153
references: Cancer Lett. 2009 Jun 28;279(1):84-92
references: 19232459
references: Reproduction. 2005 Feb;129(2):137-49
references: 15695608
references: Nat Clin Pract Endocrinol Metab. 2006 Apr;2(4):231-8
references: 16932288
references: Physiol Rev. 1982 Apr;62(2):624-71
references: 6803269
references: Dev Dyn. 2006 Sep;235(9):2292-300
references: 16881057
references: Mutat Res. 2011 May-Jun;727(3):62-71
references: 21540125
references: Biol Reprod. 2012 Dec 06;87(6):131
references: 23034159
references: Endocrinology. 2010 Jul;151(7):3363-73
references: 20444942
references: Asian Pac J Cancer Prev. 2007 Jan-Mar;8(1):13-23
references: 17477765
references: Dev Biol. 2005 Feb 15;278(2):511-25
references: 15680367
references: PLoS One. 2012;7(9):e43380
references: 22984422
references: Epigenetics. 2012 Sep;7(9):1057-70
references: 22894908
references: PLoS One. 2010 Nov 09;5(11):e13884
references: 21085488
references: Reprod Toxicol. 2013 Apr;36:104-16
references: 23453003
references: Biol Reprod. 2011 Aug;85(2):277-84
references: 21508350
references: J Reprod Fertil Suppl. 1981;30:223-30
references: 6762423
references: Curr Opin Allergy Clin Immunol. 2013 Feb;13(1):63-9
references: 23242116
references: Hum Reprod. 2011 Sep;26(9):2558-69
references: 21685136
references: Reprod Toxicol. 2012 Dec;34(4):708-19
references: 22975477
references: Development. 2009 Jan;136(1):129-38
references: 19036799
references: J Neurosci. 2011 Aug 17;31(33):11748-55
references: 21849535
references: Dev Biol. 1999 Dec 1;216(1):340-7
references: 10588883
references: PLoS One. 2012;7(9):e46249
references: 23049995
references: Endocrinology. 2009 Dec;150(12):5575-85
references: 19819939
references: Dev Dyn. 2001 Oct;222(2):228-37
references: 11668600
references: Biol Reprod. 2006 Jan;74(1):195-201
references: 16207837
references: Science. 2005 Jun 3;308(5727):1466-9
references: 15933200
references: Int J Oncol. 2007 Jan;30(1):253-60
references: 17143536
references: PLoS One. 2007 Dec 12;2(12):e1289
references: 18074014
references: Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):279-89
references: 20541152
references: EMBO J. 2005 May 18;24(10):1798-809
references: 15889150
references: Genome Res. 2011 Dec;21(12):2058-66
references: 22042642
references: Development. 2005 Jul;132(13):3045-54
references: 15944188
references: Dev Disabil Res Rev. 2010;16(2):114-9
references: 20818725
references: J Occup Med. 1979 Mar;21(3):161-6
references: 556420
references: PLoS Genet. 2011 Apr;7(4):e1002036
references: 21490963
references: PLoS One. 2012;7(4):e34327
references: 22523547
references: Mol Hum Reprod. 2008 Feb;14(2):67-74
references: 18178607
references: Eur J Hum Genet. 2010 Jan;18(1):73-80
references: 19584898
references: Reproduction. 2010 Sep;140(3):435-43
references: 20538714
references: Dev Biol. 2005 Nov 1;287(1):111-24
references: 16185683
references: Lancet. 2000 Oct 7;356(9237):1240-1
references: 11072947
references: Ann Allergy Asthma Immunol. 2011 May;106(5):355-61; quiz 362
references: 21530865