title: Laryngeal synovial sarcoma: a rare clinical entity.
abstract: Introduction. Synovial sarcomas (SS) are aggressive malignant soft tissue tumours that are thought to arise from pluripotent mesenchymal cells. Clinical Report. A 20-year-old male presented with an acute onset of respiratory stridor. Computer tomography scanning confirmed a mass arising from the left supraglottic larynx and an emergency tracheostomy was performed. A diagnosis of biphasic synovial sarcoma was formed. A total laryngectomy and left hemithyroidectomy was performed in conjunction with a left modified radical neck dissection. The patient received adjuvant chemotherapy followed by a course of radiotherapy and remains alive and disease free at 18 months after treatment. Discussion. Prognosis for patients with SS is related to primary tumour extent, grade, and size. The presence of the diagnostic translocation, t(X;18), is being targeted and hopefully will lead to the development of new therapeutics (Guadagnolo et al., 2007). Conclusion. Laryngeal SS remains a rare and poorly understood entity. A multidisciplinary approach to treatment is essential and long-term followup is imperative.
authors: St Vincents Hospital, Sydney, NSW 2010, Australia.
authors: Clair
authors: C
authors: Saxby
authors: Ron
authors: R
authors: Bova
authors: Melanie
authors: M
authors: Edwards
references: J Clin Oncol. 2003 Apr 15;21(8):1602-11
references: 12697886
references: J Transl Med. 2005 Jan 12;3(1):1
references: 15647119
references: Cancer. 1999 Jun 15;85(12):2596-607
references: 10375108
references: Med J Aust. 2012 Jan 16;196(1):72-3
references: 22256940
references: Ear Nose Throat J. 2010 Jun;89(6):280-3
references: 20556741
references: Ann Otol Rhinol Laryngol. 1998 Dec;107(12):1080-5
references: 9865642
references: J Surg Oncol. 1993 Oct;54(2):82-6
references: 8412164
references: Curr Treat Options Oncol. 2005 Nov;6(6):449-59
references: 16242050
references: Lancet. 1997 Dec 6;350(9092):1647-54
references: 9400508
references: Curr Opin Oncol. 2003 May;15(3):239-52
references: 12778019
references: Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1173-80
references: 17689031
references: Head Neck. 2007 Aug;29(8):731-40
references: 17274049
references: Gulf J Oncolog. 2011 Jan;(9):52-6
references: 21177209