title: ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients.
abstract: : Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.
authors: *Unidad de Coinfección HIV/Hepatitis, Centro Nacional de Microbiología, Hospital Carlos III, Madrid, Spain; †Plataforma de Laboratorio, Hospital General Universitario "Gregorio Marañón," Madrid, Spain; ‡Fundación para la Investigación Biomédica, Hospital General Universitario "Gregorio Marañón," Madrid, Spain; §Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Spain; ‖Servicio Microbiología, Hospital General Universitario Gregorio Marañon, Madrid, Spain; ¶Servicio de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, Madrid, Spain; #Servicio de Enfermedades Infecciosas, Hospital Virgen del Rocío, Seville, Spain; **Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain; ††Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain; and ‡‡Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
authors: María
authors: M
authors: Guzmán-Fulgencio
authors: José L
authors: JL
authors: Jiménez
authors: María A
authors: MA
authors: Jiménez-Sousa
authors: José M
authors: JM
authors: Bellón
authors: Mónica
authors: M
authors: García-Álvarez
authors: Vicente
authors: V
authors: Soriano
authors: Paloma
authors: P
authors: Gijón-Vidaurreta
authors: Enrique
authors: E
authors: Bernal-Morell
authors: Pompeyo
authors: P
authors: Viciana
authors: M Ángeles
authors: MÁ
authors: Muñoz-Fernández
authors: Salvador
authors: S
authors: Resino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D003066:Coenzyme A Ligases / Q000235:genetics* / Q000502:physiology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000235:genetics* / Q000503:physiopathology; D020276:HIV Long-Term Survivors; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D003066:Coenzyme A Ligases; C587198:ACSM4 protein, human