title: Insight into lymphoid tissue morphogenesis.
abstract: Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves interactions between haematopoietic and mesenchymal cells. Importantly, this morphogenesis potential is maintained throughout life since in chronic inflammatory conditions novel "tertiary lymphoid organs" can be generated by processes that are reminiscent of embryonic SLO development. In this review we will discuss early events in SLO morphogenesis, focusing on haematopoietic and mesenchymal cell subsets implicated on the development of lymphoid organs.
authors: Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York YO10 5DD, UK. Electronic address: mark.coles@york.ac.uk.
authors: Mark
authors: M
authors: Coles
authors: Henrique
authors: H
authors: Veiga-Fernandes
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008221:Lymphoid Tissue / Q000196:embryology / Q000254:growth & development / Q000276:immunology*; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000378:metabolism; D009024:Morphogenesis / Q000235:genetics / Q000276:immunology*
keywords: Lymphoid tissue development; Secondary lymphoid organs