title: Cell stress response in rat chronic small bowel allograft rejection.
abstract: BACKGROUND
  We sought to assess the expression of five cell stress molecules: Heat shock protein (HSP)-60, HSP-70, interferon (IFN)-α, rat retinoic acid early induible-1 like transcript (RRLT), and vasoactive intestinal peptide (VIP) during rat chronic small bowel allograft rejection.
  
  
  METHODS
  A rat model of small bowel allograft rejection was induced on postoperative day 90 using F344 rat as donor and Lewis rat as recipient.
  
  
  RESULTS
  We demonstrated increased expression of lamina propria HSP-60 (mean rank grade 8.3 and 3.2, respectively), graft RRLT (relative mRNA amount 5.1 ± 1.8 and 3.0 ± 1.3, respectively) and IFN-α (relative mRNA amount 108.3 ± 49.2 and 59.2 ± 22.0, respectively) in allograft group compared with the isograft group.
  
  
  CONCLUSIONS
  These data suggest the presence of cell stress during chronic small bowel allograft rejection.
authors: Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors: J
authors: J
authors: Wang
authors: Y
authors: Y
authors: Li
authors: J
authors: J
authors: Li
mesh_terms: D064591:Allografts; D000818:Animals; D018834:Chaperonin 60 / Q000235:genetics / Q000378:metabolism; D002908:Chronic Disease; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006084:Graft Rejection / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D016898:Interferon-alpha / Q000235:genetics / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology / Q000637:transplantation*; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D020365:RNA Helicases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013312:Stress, Physiological; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000235:genetics / Q000378:metabolism
chemical_list: D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; C557067:Hspd1 protein, rat; D016898:Interferon-alpha; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D014660:Vasoactive Intestinal Peptide; C556407:RIG-I protein, rat; D020365:RNA Helicases