title: Establishment and characterization of a canine xenograft model of inflammatory mammary carcinoma.
abstract: Canine inflammatory mammary cancer (IMC) and human inflammatory breast cancer (IBC) are the most aggressive form of mammary/breast cancer. Both species naturally develop it, sharing epidemiological, clinical and histological characteristics. Thus, IMC has been suggested as a model to study the human disease. We have developed the first IMC xenograft model in SCID mice. Xenografts reproduced the histological features from the primary tumor, were highly aggressive and showed dermal tumor emboli, distinctive hallmarks of IMC/IBC. This model was hormone receptors positive and HER2 negative. Our findings showed that estrogens and androgens are locally produced in tissues. Factors related to tumor vascularization showed positive expression and xenografts with the highest expression of all analyzed vascular factors had the highest rate of tumor proliferation. The role of steroid hormones and the angio/lymphangiogenic properties found in this model, provide additional knowledge for future interventions in the diagnosis, treatment and prevention of the disease.
authors: Department of Animal Physiology, Veterinary Medicine School, Complutense University of Madrid, Madrid, Spain. Electronic address: laura_mond@hotmail.com.
authors: L
authors: L
authors: Camacho
authors: L
authors: L
authors: Peña
authors: A
authors: A
authors: González Gil
authors: S
authors: S
authors: Cáceres
authors: L
authors: L
authors: Díez
authors: J C
authors: JC
authors: Illera
mesh_terms: D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D001940:Breast / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004958:Estradiol / Q000378:metabolism; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D064593:Heterografts / Q000473:pathology; D058922:Inflammatory Breast Neoplasms / Q000473:pathology / Q000662:veterinary*; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation / Q000473:pathology / Q000662:veterinary*; D011374:Progesterone / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
chemical_list: D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D051546:Cyclooxygenase 2; C017296:estrone sulfate
keywords: Canine; Hormones; Inflammatory breast cancer; SCID mice; Vascular factors; Xenograft