title: Rash and hepatitis within days of starting a new antiretroviral regimen: nevirapine hypersensitivity, secondary syphilis or both?
abstract: We report a case in which an HIV-positive man developed general malaise, skin rash and biochemical hepatitis within days of starting a nevirapine-based antiretroviral treatment regimen. At the same time, his syphilis serology proved positive. We discuss the diagnostic dilemma: was this a nevirapine hypersensitivity reaction, secondary syphilis or both?
authors: Department of Genitourinary Medicine, North Manchester General Hospital, Pennine Acute Hospital NHS Trust, Manchester, UK.
authors: Cara J
authors: CJ
authors: Saxon
authors: Matthew R
authors: MR
authors: Helbert
authors: Adeniyi J
authors: AJ
authors: Komolafe
authors: Stephen P
authors: SP
authors: Higgins
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D003937:Diagnosis, Differential; D005076:Exanthema / Q000139:chemically induced*; D015658:HIV Infections / Q000188:drug therapy*; D006505:Hepatitis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy; D007630:Kenya; D019829:Nevirapine / Q000009:adverse effects* / Q000627:therapeutic use; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D019829:Nevirapine
keywords: AIDS; HIV; antiretroviral toxicity; diagnosis; nevirapine; syphilis