title: Abnormal expression of e-cadherin in gastric adenocarcinoma, and its correlation with tumor histopathology and helicobacter pylori infection.
abstract: BACKGROUND
  Gastric cancer is one of the leading cancers in the world especially in Iran. There are many genomic and molecular factors that cause gastric cancer to occur, and also there are many markers that associate with tumor invasiveness. E-cadherin is a tumor suppressor gene which produces E-cadherin transmembrane protein, a molecule which plays an important role in adhesion and differentiation of epithelial cells.
  
  
  OBJECTIVE
  In this study, we evaluated the prevalence of abnormal E-cadherin expression in Iranian patients with gastric adenocarcinoma, and tried to find its correlation with H. pylori infection and tumor histopathology.
  
  
  METHODS
  A historical cohort survey was performed on tissue samples obtained from 95 total or partial gastrectomy with gastric adenocarcinoma. The immunohistochemistry and Giemsa staining were used to assess E-cadherin expression, and H- pylori infection respectively. The association between abnormal E-cadherin expression and tumor histopathology characteristics include depth of tumor invasion, tumor differentiation, tumor phenotype, tumor type, tumor size, neurovascular invasion of tumor, and regional lymph node involvement and H- pylori infection and patient's age and sex, were evaluated in all patients.
  
  
  RESULTS
  Abnormal E-cadherin expression was noted in 38% of patients, and 59% of patients were infected with H-pylori. A significant correlation was seen between abnormal E-cadherin expression, and tumor grade and regional lymph node involvement. We could not find any significant association between abnormal E-cadherin expression and H- pylori infection, patient's age and sex, tumor phenotype, tumor type, depth of tumor invasion, tumor size, and neurovascular invasion of tumor.
  
  
  CONCLUSIONS
  Abnormal E-cadherin expression is a common phenomenon in gastric adenocarcinoma. The study showed a significant correlation between abnormal E-cadherin expression and tumor grade and regional lymph node involvement; so, abnormal E-cadherin expression may be used as a predictive factor for tumor invasiveness in gastric adenocarcinoma.
authors: Oncology Department, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Robab
authors: R
authors: Anbiaee
authors: Khosrow
authors: K
authors: Mojir Sheibani
authors: Peyman
authors: P
authors: Torbati
authors: Hanieh
authors: H
authors: Jaam
keywords: Cadherin; Helicobacter Pylori; Stomach Neoplasms
references: Rev Med Chil. 2006 Aug;134(8):1002-9
references: 17130988
references: Oncology. 2001;60(4):339-45
references: 11408802
references: World J Gastroenterol. 2002 Dec;8(6):987-93
references: 12439911
references: Gastroenterology. 1997 Jan;112(1):46-54
references: 8978342
references: Gut. 2003 Apr;52(4):502-6
references: 12631658
references: Clin Cancer Res. 2004 Apr 15;10(8):2784-9
references: 15102685
references: J Clin Pathol. 1998 May;51(5):410-2
references: 9708215
references: Ann Oncol. 2004 Mar;15(3):489-92
references: 14998854