title: Narrow band imaging with magnification endoscopy for celiac disease: results from a prospective, single-center study.
abstract: In celiac disease (CD), the intestinal lesions can be patchy and partial villous atrophy may elude detection at standard endoscopy (SE). Narrow Band Imaging (NBI) system in combination with a magnifying endoscope (ME) is a simple tool able to obtain targeted biopsy specimens. The aim of the study was to assess the correlation between NBI-ME and histology in CD diagnosis and to compare diagnostic accuracy between NBI-ME and SE in detecting villous abnormalities in CD. Forty-four consecutive patients with suspected CD undergoing upper gastrointestinal endoscopy have been prospectively evaluated. Utilizing both SE and NBI-ME, observed surface patterns were compared with histological results obtained from biopsy specimens using the k-Cohen agreement coefficient. NBI-ME identified partial villous atrophy in 12 patients in whom SE was normal, with sensitivity, specificity, and accuracy of 100%, 92.6%, and 95%, respectively. The overall agreement between NBI-ME and histology was significantly higher when compared with SE and histology (kappa score: 0.90 versus 0.46; P = 0.001) in diagnosing CD. NBI-ME could help identify partial mucosal atrophy in the routine endoscopic practice, potentially reducing the need for blind biopsies. NBI-ME was superior to SE and can reliably predict in vivo the villous changes of CD.
authors: Gastroenterology and Digestive Endoscopy Unit, "San Salvatore" Hospital, Piazzale Cinelli, 1-61121 Pesaro, Italy.
authors: L
authors: L
authors: De Luca
authors: L
authors: L
authors: Ricciardiello
authors: M B L
authors: MB
authors: Rocchi
authors: M T
authors: MT
authors: Fabi
authors: M L
authors: ML
authors: Bianchi
authors: A
authors: A
authors: de Leone
authors: S
authors: S
authors: Fiori
authors: D
authors: D
authors: Baroncini
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