title: Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk.
abstract: Potential single-nucleotide polymorphisms (SNPs) of interleukin-4 receptor alpha (IL-4Rα) rs1801275 and rs1805015 have been implicated in glioma risk; however, the findings of previous published case-control studies are conflicting and inconclusive. We performed the updated meta-analysis with the aim to provide a more precise estimate for the role of interleukin-4Rα SNPs in glioma risk. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the gene association. Overall, the pooled analysis showed that the IL-4Rα rs1801275 polymorphism was associated with a decreased risk of glioma in the comparison of G vs. A (OR = 0.87, 95% CI = 0.76-0.99, P OR = 0.041). Subgroup analysis by ethnicity revealed that the IL-4Rα rs1801275 variant G and GG + AG exerted a decreased risk effect on the development of glioma among Asians, but not Caucasians (G vs. A, OR = 0.81, 95% CI = 0.69-0.95, P OR = 0.011; GG + AG vs. AA, OR = 0.80, 95% CI = 0.66-0.96, P OR = 0.018). However, the IL-4Rα rs1805015 polymorphism did not modify the risk of glioma. Sensitivity analysis confirmed the reliability for all of the results. Our meta-analysis suggests that the polymorphism of IL-4Rα rs1801275 but not IL-4Rα rs1805015 plays a protective role in the glioma pathogenesis, particularly among Asians.
authors: Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, Yancheng, 224001, People's Republic of China.
authors: Jun
authors: J
authors: Guo
authors: Lei
authors: L
authors: Shi
authors: Min
authors: M
authors: Li
authors: Jin
authors: J
authors: Xu
authors: Shushan
authors: S
authors: Yan
authors: Chuang
authors: C
authors: Zhang
authors: Guan
authors: G
authors: Sun
mesh_terms: D000483:Alleles; D001932:Brain Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D005838:Genotype; D005910:Glioma / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: D053662:Interleukin-4 Receptor alpha Subunit
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