title: An in vivo insight to the toxicological profile of various organotellurides.
abstract: In this study we have examined the in vivo toxic effects of various organochalcogens on hepatic, renal, glycemic and lipid profile. Diorganotellurium dichloride phosphonate (C1) at all tested doses did not modify serum alanine aminotransferase (ALT) activity in mice. While, 2-butyltellurium furan (C2) and dinaphthalene ditelluride (C3) at a dose of 0.75 and 0.125 mmol/kg caused an increase in aspartate aminotransferase (AST) and ALT activities. Our data showed that C1 caused an increase in urea content at different doses while treatment with C2 and C3 did not modify urea content. Treatment with C2 caused a significant alteration in serum glucose and fructosamine levels which explains the possible toxicity of these compounds. No significant changes were observed for cholesterol and triglycerides levels. These results suggest that organochalcogen compounds presented liver and renal toxicity and also altered glycemic profile which may leads to various clinical complications.
authors: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors: Viviane Patrícia P
authors: VP
authors: Schiar
authors: Danúbia B
authors: DB
authors: dos Santos
authors: Marta M M F
authors: MM
authors: Duarte
authors: Fabrício
authors: F
authors: Vargas
authors: Marinei C P
authors: MC
authors: Ribeiro
authors: Cristina W
authors: CW
authors: Nogueira
authors: Gilson
authors: G
authors: Zeni
authors: Waseem
authors: W
authors: Hassan
authors: João B T
authors: JB
authors: da Rocha
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D019270:Fructosamine / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D007677:Kidney Function Tests; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D016019:Survival Analysis; D013691:Tellurium / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D008055:Lipids; D009942:Organometallic Compounds; D019270:Fructosamine; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013691:Tellurium
keywords: Haemoglobin content; Organochalcogens; Renal and hepatic toxicity