title: Negative reward expectations in Borderline Personality Disorder patients: neurophysiological evidence.
abstract: Borderline Personality Disorder (BPD) patients present profound disturbances in affect regulation and impulse control which could reflect a dysfunction in reward-related processes. The current study investigated these processes in a sample of 18 BPD patients and 18 matched healthy controls, using an event-related brain potentials methodology. Results revealed a reduction in the amplitude of the Feedback-Related Negativity of BPD patients, which is a neurophysiological index of the impact of negative feedback in reward-related tasks. This reduction, in the effect of negative feedback in BPD patients, was accompanied by a different behavioral pattern of risk choice compared to healthy participants. These findings confirm a dysfunctional reward system in BDP patients, which might compromise their capacity to build positive expectations of future rewards and decision making.
authors: Servei de Psiquiatria i Salut Mental, Hospital d'Igualada (Consorci Sanitari de l'Anoia), Igualada, Barcelona 08700, Spain; Unitat de Psicologia Mèdica, Departament de Psiquiatria i Medicina Legal & Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Cognition and Brain Plasticity Group [Bellvitge Biomedical Research Institute - IDIBELL], L'Hospitalet de Llobregat, Barcelona 08097, Spain.
authors: Daniel
authors: D
authors: Vega
authors: Àngel
authors: À
authors: Soto
authors: Julià L
authors: JL
authors: Amengual
authors: Joan
authors: J
authors: Ribas
authors: Rafael
authors: R
authors: Torrubia
authors: Antoni
authors: A
authors: Rodríguez-Fornells
authors: Josep
authors: J
authors: Marco-Pallarés
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D000704:Analysis of Variance; D001883:Borderline Personality Disorder / Q000503:physiopathology* / Q000523:psychology; D016009:Chi-Square Distribution; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D030141:Feedback, Psychological / Q000502:physiology*; D005260:Female; D005717:Games, Experimental; D006801:Humans; D008875:Middle Aged; D012201:Reward; D011795:Surveys and Questionnaires; D064232:Visual Analog Scale; D055815:Young Adult
keywords: Borderline Personality Disorder; Error; Feedback-Related Negativity; Reward; Theta oscillatory activity