title: CD105 (endoglin) is highly overexpressed in a subset of cases of acute myeloid leukemias.
abstract: OBJECTIVE
  To assess CD105 (endoglin) expression in 119 acute myeloid leukemia (AML) and 13 control cases using immunohistochemistry.
  
  
  METHODS
  CD105 expression was assessed retrospectively by using immunohistochemistry in bone marrow specimens.
  
  
  RESULTS
  CD105 was strongly and diffusely positive in all 9 (100%) AMLs with t(15;17)(q24.1;q21.2), 2 (100%) AMLs with t(8;21)(q22;q22), 1 (100%) AML with t(6;9)(p23;q34), 7 (28%) of 25 AMLs with myelodysplasia-related changes, 1 (33%) of 3 therapy-related AMLs, 3 (16%) of 19 AMLs unclassifiable, 1 (14%) of 7 AMLs with inv(16)(p13.1q22), and 5 (11%) of 45 AMLs not otherwise specified. Uninvolved bone marrow in these cases showed no CD105 expression by erythroid precursors, megakaryocytes, or endothelial or stromal cells. Two of 13 control bone marrow specimens showed partial CD105 positivity in myeloid cells. In 21 strongly CD105+ AML cases tested for the IDH2 mutation, 9 (42%) were mutated (P = .004).
  
  
  CONCLUSIONS
  These data suggest that CD105 could be a therapeutic target in a subset of patients with AML.
authors: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 072, Houston, TX 77030, USA.
authors: Zaher I
authors: ZI
authors: Chakhachiro
authors: Zhuang
authors: Z
authors: Zuo
authors: Tariq N
authors: TN
authors: Aladily
authors: Hagop M
authors: HM
authors: Kantarjian
authors: Jorge E
authors: JE
authors: Cortes
authors: Khaled
authors: K
authors: Alayed
authors: Martin H
authors: MH
authors: Nguyen
authors: L Jeffrey
authors: LJ
authors: Medeiros
authors: Carlos
authors: C
authors: Bueso-Ramos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D000071063:Endoglin; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface
keywords: Acute myeloid leukemia; CD105; Endoglin; IDH2 mutation; Immunohistochemistry