title: Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease.
abstract: C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD.
authors: Department of Internal Medicine, University of Pennsylvania, Philadelphia, PA, United States.
authors: Mark
authors: M
authors: Yarchoan
authors: Natalia
authors: N
authors: Louneva
authors: Sharon X
authors: SX
authors: Xie
authors: Frank J
authors: FJ
authors: Swenson
authors: William
authors: W
authors: Hu
authors: Holly
authors: H
authors: Soares
authors: John Q
authors: JQ
authors: Trojanowski
authors: Virginia M-Y
authors: VM
authors: Lee
authors: Mitchel A
authors: MA
authors: Kling
authors: Leslie M
authors: LM
authors: Shaw
authors: Alice
authors: A
authors: Chen-Plotkin
authors: David A
authors: DA
authors: Wolk
authors: Steven E
authors: SE
authors: Arnold
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis* / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010949:Plasma / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Alzheimer disease; Apolipoprotein E; Biological markers; C-reactive protein; Inflammation; Mild cognitive impairment
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