title: Intravenous thrombolysis for acute ischemic stroke occurring during hospitalization for transient ischemic attack.
abstract: BACKGROUND
  There are limited data regarding the use of intravenous thrombolysis in patients who experienced acute ischemic symptoms during their hospitalization for prior transient ischemic attack.
  
  
  OBJECTIVE
  We sought to prospectively evaluate the safety and efficacy of intravenous thrombolysis for the treatment of acute ischemic stroke occurring during hospitalization for transient ischemic attack in an international, multicenter study.
  
  
  METHODS
  Consecutive patients with acute ischemic stroke that occurred during hospitalization for prior transient ischemic attack were treated with intravenous thrombolysis in five tertiary-care stroke centers. Early arterial recanalization was determined by transcranial Doppler at the end of recombinant tissue plasminogen activator infusion using previously validated criteria. Symptomatic intracranial hemorrhage complicating intravenous thrombolysis was evaluated using the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study definition. Functional independence at three-months was defined as Modified Rankin Scale score of 0-2.
  
  
  RESULTS
  Systemic recombinant tissue plasminogen activator infusion (median onset-to-treatment time 70 mins, interquartile range 50-150) was given in 25 consecutive patients (mean age 66 ± 10 years) who developed acute ischemic stroke symptoms (median National Institutes of Health Stroke Scale score 10 points; interquartile range 8-14) during hospitalization for prior transient ischemic attack (median ABCD(2) score 5 points; median time-to-symptom recurrence 24 h, interquartile range 24-48). No symptomatic intracranial hemorrhage (0%; 95% confidence interval 0-12%) was documented. Early complete recanalization occurred in 64% of patients (95% confidence interval 44-80%), and 84% (95% confidence interval 65-94%) achieved three-month functional independence. The rate of three-month functional independence was higher in patients treated with intravenous tissue plasminogen activator within 90 mins from symptom onset compared with those with onset-to-treatment time>90 mins (81% vs. 33%; P = 0.031).
  
  
  CONCLUSIONS
  Intravenous thrombolysis for symptoms of acute ischemic stroke occurring after hospitalization for transient ischemic attack appears to be safe. These pilot data support resetting the clock if new symptoms recur shortly after transient ischemic attack.
authors: Second Department of Neurology, School of Medicine, University of Athens, Athens, Greece; Department of Neurology, Democritus University of Thrace, Alexandroupolis, Greece; International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic.
authors: Georgios
authors: G
authors: Tsivgoulis
authors: Vijay K
authors: VK
authors: Sharma
authors: Robert
authors: R
authors: Mikulik
authors: Christos
authors: C
authors: Krogias
authors: Michal
authors: M
authors: Haršány
authors: Reza
authors: R
authors: Bavarsad Shahripour
authors: Dimitrios
authors: D
authors: Athanasiadis
authors: Hock Luen
authors: HL
authors: Teoh
authors: Charitomeni
authors: C
authors: Piperidou
authors: Andrei V
authors: AV
authors: Alexandrov
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006470:Hemorrhage / Q000209:etiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007391:International Cooperation; D002546:Ischemic Attack, Transient / Q000150:complications*; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D020521:Stroke / Q000628:therapy*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: acute ischemic stroke; intravenous thrombolysis; transient ischemic attack