title: Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments.
abstract: Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.
authors: Center for International Health Research.
authors: Emily A
authors: EA
authors: McDonald
authors: Sunthorn
authors: S
authors: Pond-Tor
authors: Blanca
authors: B
authors: Jarilla
authors: Marianne J
authors: MJ
authors: Sagliba
authors: Annaliza
authors: A
authors: Gonzal
authors: Amabelle J
authors: AJ
authors: Amoylen
authors: Remigio
authors: R
authors: Olveda
authors: Luz
authors: L
authors: Acosta
authors: Fusun
authors: F
authors: Gundogan
authors: Lisa M
authors: LM
authors: Ganley-Leal
authors: Jonathan D
authors: JD
authors: Kurtis
authors: Jennifer F
authors: JF
authors: Friedman
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D016207:Cytokines / Q000097:blood; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D010679:Philippines; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000473:pathology*; D012554:Schistosomiasis japonica / Q000473:pathology*
chemical_list: D016207:Cytokines; D004731:Endotoxins
keywords: S. japonicum; endotoxin; pregnancy
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