title: High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.
abstract: Apolipoprotein E ε4 allele (APOE ε4) increases the apolipoprotein E (apoE) protein levels in Alzheimer's disease (AD) cerebrospinal fluid (CSF). Thus, we hypothesized that apoE levels were also associated with the APOE genotype, and amyloid-β (Aβ)-associated clinical, functional, and imaging parameters in patients with Lewy body-associated disorders (LBD). Indeed, similar to AD, patients with LBD displayed high CSF apoE levels (greatest in patients with dementia with LBD), and this was linked to APOE ε4. High CSF apoE protein correlated positively with CSF soluble amyloid precursor protein, total tau, and cortical and striatal Pittsburgh compound B retention; and correlated negatively with CSF Aβ42, cognitive tests scores, and glucose uptake ratio in the temporal and parietal cortices. APOE ε4-triggered accumulation of apoE in CSF is related to Aβ-associated clinical and functional imaging parameters in LBD. Accordingly, therapeutic strategies aimed at reducing apoE levels in the brain should be explored not only in AD but also in LBD, particularly when accompanied with dementia.
authors: Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Neurobiology Center, Stockholm, Sweden.
authors: Swetha
authors: S
authors: Vijayaraghavan
authors: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, Tuebingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Tuebingen, Germany.
authors: Walter
authors: W
authors: Maetzler
authors: Nuclear Medicine and PET Center, University of Tuebingen, Tuebingen, Germany.
authors: Matthias
authors: M
authors: Reimold
authors: Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Neurobiology Center, Stockholm, Sweden.
authors: Christina Unger
authors: CU
authors: Lithner
authors: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, Tuebingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Tuebingen, Germany.
authors: Inga
authors: I
authors: Liepelt-Scarfone
authors: Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, Tuebingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tuebingen, Tuebingen, Germany.
authors: Daniela
authors: D
authors: Berg
authors: Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Neurobiology Center, Stockholm, Sweden. Electronic address: Taher.Darreh-Shori@ki.se.
authors: Taher
authors: T
authors: Darreh-Shori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid; D000814:Aniline Compounds; D001057:Apolipoproteins E / Q000134:cerebrospinal fluid* / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002250:Carbon Radioisotopes; D015331:Cohort Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000235:genetics / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013844:Thiazoles; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000814:Aniline Compounds; D001057:Apolipoproteins E; D015415:Biomarkers; D002250:Carbon Radioisotopes; C054369:MAPT protein, human; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; D013844:Thiazoles; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Alzheimer’s disease; Amyloid-β; Apolipoprotein E; Cerebrospinal fluid; Dementia with Lewy bodies; Fluorodeoxyglucose–positron emission tomography; Lewy body-associated disorders; Pittsburgh compound B–positron emission tomography; Positron emission tomography