title: Morning plasma cortisol is low among obese women with polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is the most common cause for androgen excess in women. It is associated with wide variety of metabolic disorders. The present study assessed morning plasma cortisol in women with PCOS. One hundred and ninety seven cases and 55 controls were enrolled for this study. The mean age of patients and controls were 23 ± 5.6 years and 25 ± 4.3 years. One hundred twelve (56%) women with PCOS had BMI >25. Serum cortisol levels were significantly higher in lean PCOS women compared to controls (13.4 ± 5.1 versus 11.3 ± 4.5, p < 0.01) and over-weight PCOS women group (13.4 ± 5.1 versus 9.3 ± 3.2, p < 0.01). There was a trend for less acne and hirsutism with increase in BMI. Morning plasma cortisol was lower among obese women with PCOS. Morning plasma cortisol correlated negatively with BMI in PCOS women with normal glucose tolerance.
authors: Department of Endocrinology & Metabolism and.
authors: Iram
authors: I
authors: Shabir
authors: Mohd Ashraf
authors: MA
authors: Ganie
authors: Edavan P
authors: EP
authors: Praveen
authors: Madan L
authors: ML
authors: Khurana
authors: Jomimol
authors: J
authors: John
authors: Nandita
authors: N
authors: Gupta
authors: Guresh
authors: G
authors: Kumar
authors: Ariachery C
authors: AC
authors: Ammini
mesh_terms: D000152:Acne Vulgaris / Q000150:complications / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002940:Circadian Rhythm; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006628:Hirsutism / Q000150:complications / Q000453:epidemiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D013739:Testosterone; D006854:Hydrocortisone