title: [Genetic predictors of sick sinus node syndrome].
abstract: The article is devoted to the role of heredity in development of the sick sinus node syndrome (SSNS). We have examined 14 probands and 110 their relatives from families with idiopathic SSNS and established the role in development of hereditary SSNS of polymorphisms of the following genes: -2-adrenoreceptor, enzyme endothelial NO synthase, protein connexin 40, voltage dependent cardiac sodium channels, cardiac myosin heavy chains. We also revealed associations of clinical variants of idiopathic SSNS with genotypes of the studied genes.
authors: A A
authors: AA
authors: Chernova
authors: S Iu
authors: SIu
authors: Nikulina
authors: S S
authors: SS
authors: Tret'iakova
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012804:Sick Sinus Syndrome / Q000235:genetics / Q000503:physiopathology