title: Effect of supplemental vitamin E on antibody titer in Japanese black calves vaccinated against bovine herpesvirus-1.
abstract: We investigated the effect of supplemental vitamin E on antibody titer against bovine herpesvirus-1 (BHV-1) in Japanese Black calves after vaccination with modified live virus. Thirty calves kept at the same farm were studied. They were divided into two groups; fifteen calves received 300 IU/day of vitamin E orally from 1 to 3 months of age (VE Group), and the other fifteen calves did not receive vitamin E supplement (Control Group). BHV-1 modified live vaccine was injected twice to all calves when they were 2 and 3 months of age. Following the vaccination, serum vitamin E concentration and neutralizing antibody titer to BHV-1 were measured over time. VE Group showed higher serum vitamin E at 2, 3 and 4 months of age compared to Control Group (P<0.05). The antibody titer in Control Group was the highest at 1 month of age, and it gradually decreased until 4 months of age. VE Group showed increase in antibody titer at 4 months of age resulting in significant difference (P<0.01) from Control Group. This study demonstrated that vitamin E supplementation to Japanese Black calves could increase antibody production after the second modified live BHV-1 vaccination.
authors: Kagoshima Prefectural Federation of Agricultural Mutual Aid Associations, Kagoshima 891-0132, Japan.
authors: Konosuke
authors: K
authors: Otomaru
authors: Shun
authors: S
authors: Saito
authors: Karura
authors: K
authors: Endo
authors: Masayuki
authors: M
authors: Kohiruimaki
authors: Shin-Ichi
authors: S
authors: Fukuyama
authors: Hiromichi
authors: H
authors: Ohtsuka
mesh_terms: D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000187:drug effects*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control* / Q000821:virology*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D019587:Dietary Supplements; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007564:Japan; D009500:Neutralization Tests / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*
chemical_list: D000914:Antibodies, Viral; D014810:Vitamin E
references: Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):53-63
references: 16772096
references: Poult Sci. 1997 Jul;76(7):984-91
references: 9200234
references: J Nutr. 2000 Dec;130(12):2932-7
references: 11110849
references: Proc Nutr Soc. 1991 Aug;50(2):245-9
references: 1749793
references: Anim Sci J. 2011 Feb;82(1):93-8
references: 21269366
references: J Dairy Sci. 2005 Jan;88(1):195-210
references: 15591383
references: Acta Vet Scand. 1978;19(4):497-505
references: 217258
references: J Dairy Sci. 1987 May;70(5):993-9
references: 3597940
references: J Dairy Sci. 1982 Dec;65(12):2357-65
references: 7161433
references: Can J Comp Med. 1983 Jan;47(1):57-63
references: 6299485
references: Can J Comp Med. 1985 Jan;49(1):10-4
references: 2985214
references: Clin Chem. 1978 Apr;24(4):585-90
references: 639263
references: J Dairy Sci. 1987 Jan;70(1):123-9
references: 3571614