title: Non-occupational post-exposure prophylaxis for HIV at St Michael's Hospital, Toronto: a retrospective review of patient eligibility and clinical outcomes.
abstract: Stringent eligibility criteria, drug costs and antiretroviral toxicities are challenges in delivering HIV non-occupational post-exposure prophylaxis (nPEP). We reviewed patients' nPEP eligibility and clinical outcomes at St Michael's Hospital, Toronto, Canada to identify opportunities for improvement. Of 241 patients, 59%, 36% and 6% presented for high- (receptive anal/vaginal, blood), medium- (insertive anal/vaginal) and low-risk (oral) sexual exposures, respectively, and nearly all (93%) presented within 72 hours. Of 205 patients given nPEP, 20 were known to have discontinued nPEP prematurely: three due to costs but none due to toxicities. Two HIV seroconversions occurred in patients with suspected ongoing potential exposures. Five asymptomatic syphilis diagnoses were made among 71 tested. Only 39% and 19% of nPEP patients returned to our institution for follow-up at 3-4 and six months, respectively. Our findings underscore the feasibility and importance of nPEP programmes to HIV and sexually transmitted infection control, while identifying opportunities for improvement.
authors: Division of Infectious Diseases, Department of Medicine, St Michael's Hospital, Toronto, Canada.
authors: A C H
authors: AC
authors: Chan
authors: K
authors: K
authors: Gough
authors: D
authors: D
authors: Yoong
authors: M
authors: M
authors: Dimeo
authors: D H S
authors: DH
authors: Tan
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002170:Canada; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004608:Eligibility Determination; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D010349:Patient Compliance; D056990:Post-Exposure Prophylaxis; D015397:Program Evaluation; D012017:Referral and Consultation; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; PEPSE; antiretroviral; cohort study; injection drug use; nPEP; non-occupational; postexposure prophylaxis; prevention; sexual exposure; sexually transmitted infections; toxicity