title: Internal heavy atom effect of Au(III) and Pt(IV) on hypocrellin A for enhanced in vitro photodynamic therapy of cancer.
abstract: Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced (1)O2 generation quantum yield through the increased intersystem crossing efficiency mediated by internal heavy atom effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the heavy-atom effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy.
authors: College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
authors: Lin
authors: L
authors: Zhou
authors: Xuefeng
authors: X
authors: Ge
authors: Jihua
authors: J
authors: Liu
authors: Jiahong
authors: J
authors: Zhou
authors: Shaohua
authors: S
authors: Wei
authors: Fuyou
authors: F
authors: Li
authors: Jian
authors: J
authors: Shen
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D019216:Metals, Heavy / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D019800:Phenol; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D056831:Coordination Complexes; D019216:Metals, Heavy; D017319:Photosensitizing Agents; D011809:Quinones; D019800:Phenol; D010984:Platinum; D010569:Perylene; D006046:Gold; C048388:hypocrellin A
keywords: Anticancer activity; Complex; Hypocrellin A; Internal heavy atom effect; Intersystem crossing