title: Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
abstract: Previous studies have reported that the hypothalamic-pituitary-adrenal axis is involved with personality traits. We examined the association between corticotropin-releasing hormone receptor (CRHR) genes and personality traits. We investigated the 12 single-nucleotide polymorphisms of intron CRHR (six in CRHR1 and six in CRHR2, respectively) in 218 healthy volunteers using TaqMan PCR assays. Personality traits were assessed using the Revised NEO-Personality Inventory, the Temperament and Character Inventory, and the State-Trait Anxiety Inventory. No significant associations were observed between CRHR1 and CRHR2 expression and personality traits. These results fail to provide support for an association of CRHR1 and CRHR2 with personality traits in a Japanese adult population.
authors: Department of Neuropsychiatry, Faculty of Medicine, Oita University, Oita, Japan.
authors: Yoshinobu
authors: Y
authors: Ishitobi
authors: Shinya
authors: S
authors: Nakayama
authors: Masayuki
authors: M
authors: Kanehisa
authors: Haruka
authors: H
authors: Higuma
authors: Yoshihiro
authors: Y
authors: Maruyama
authors: Shizuko
authors: S
authors: Okamoto
authors: Ayako
authors: A
authors: Inoue
authors: Junko
authors: J
authors: Imanaga
authors: Yoshihiro
authors: Y
authors: Tanaka
authors: Jusen
authors: J
authors: Tsuru
authors: Hiroaki
authors: H
authors: Hanada
authors: Jotaro
authors: J
authors: Akiyoshi
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D000099052:CRF Receptor, Type 1
chemical_list: C101531:CRF receptor type 2; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1