title: Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
abstract: Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2,938 adolescents and young adults ages 12-25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.
authors: Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, NY, USA. chorlian@hbnl.downstate.edu
authors: David B
authors: DB
authors: Chorlian
authors: Madhavi
authors: M
authors: Rangaswamy
authors: Niklas
authors: N
authors: Manz
authors: Jen-Chyong
authors: JC
authors: Wang
authors: Danielle
authors: D
authors: Dick
authors: Laura
authors: L
authors: Almasy
authors: Lance
authors: L
authors: Bauer
authors: Kathleen
authors: K
authors: Bucholz
authors: Tatiana
authors: T
authors: Foroud
authors: Victor
authors: V
authors: Hesselbrock
authors: Sun J
authors: SJ
authors: Kang
authors: John
authors: J
authors: Kramer
authors: Sam
authors: S
authors: Kuperman
authors: John
authors: J
authors: Nurnberger
authors: John
authors: J
authors: Rice
authors: Marc
authors: M
authors: Schuckit
authors: Jay
authors: J
authors: Tischfield
authors: Howard J
authors: HJ
authors: Edenberg
authors: Alison
authors: A
authors: Goate
authors: Laura
authors: L
authors: Bierut
authors: Bernice
authors: B
authors: Porjesz
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000428:Alcohol Drinking / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D000437:Alcoholism / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D043585:Receptor, Muscarinic M2 / Q000235:genetics; D055815:Young Adult
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2
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