title: Enzyme-responsive supramolecular nanovalves crafted by mesoporous silica nanoparticles and choline-sulfonatocalix[4]arene [2]pseudorotaxanes for controlled cargo release.
abstract: Mesoporous silica nanoparticles (MSNs) have been surface-functionalized with choline moieties encircled by sulfonatocalix[4]arenes. Two enzyme cleavable sites are incorporated in the stalks for specific enzymes to regulate the release of loaded cargos from MSNs. These gated materials show a clear enzymatic response and proven orthogonality.
authors: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, P. R. China. ywyang@jlu.edu.cn yywfrank@gmail.com.
authors: Yu-Long
authors: YL
authors: Sun
authors: Yue
authors: Y
authors: Zhou
authors: Qing-Lan
authors: QL
authors: Li
authors: Ying-Wei
authors: YW
authors: Yang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D047250:Calixarenes / Q000737:chemistry*; D002794:Choline / Q000737:chemistry; D004798:Enzymes / Q000378:metabolism*; D004950:Esterases / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry; D043862:Rotaxanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004798:Enzymes; C509968:MCM-41; D010636:Phenols; D012235:Rhodamines; D043862:Rotaxanes; D013451:Sulfonic Acids; C121325:calix(4)arene; D047250:Calixarenes; D012822:Silicon Dioxide; D004950:Esterases; C029773:rhodamine B; D002794:Choline