title: Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people.
abstract: We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.
authors: Lipids and Atherosclerosis Research Unit, IMIBIC/Reina Sofía University Hospital/University of Córdoba, Avda. Menéndez Pidal, s/n, 14004, Córdoba, Spain.
authors: Eliana Romina
authors: ER
authors: Meza-Miranda
authors: Antonio
authors: A
authors: Camargo
authors: Oriol Alberto
authors: OA
authors: Rangel-Zuñiga
authors: Javier
authors: J
authors: Delgado-Lista
authors: Antonio
authors: A
authors: Garcia-Rios
authors: Pablo
authors: P
authors: Perez-Martinez
authors: Inma
authors: I
authors: Tasset-Cuevas
authors: Isaac
authors: I
authors: Tunez
authors: Francisco J
authors: FJ
authors: Tinahones
authors: Francisco
authors: F
authors: Perez-Jimenez
authors: José
authors: J
authors: Lopez-Miranda
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000375:Aging; D018592:Cross-Over Studies; D038441:Diet, Mediterranean; D004041:Dietary Fats / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D019518:Postprandial Period / Q000502:physiology*; D011379:Prognosis; D012313:RNA / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000235:genetics; D054481:Thioredoxin Reductase 1 / Q000096:biosynthesis / Q000235:genetics; D000099156:Superoxide Dismutase 2
chemical_list: D004041:Dietary Fats; D012313:RNA; D013482:Superoxide Dismutase; D054481:Thioredoxin Reductase 1; D000099156:Superoxide Dismutase 2
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