title: Impact of the gut microbiome on mucosal inflammation.
abstract: In the past 10 years it has become increasingly apparent that the gut microbiome has profound effects on the immune system to which it is juxtaposed, the mucosal immune system. Here, I explore recent studies in which the effects of the microbiota expand or facilitate anti-inflammatory or regulatory immunological machinery or which favor development of proinflammatory immunological machinery in this system. I then focus on how these opposing processes play out in inflammatory bowel disease (IBD); a disease in which normal immune homeostasis is disturbed and inflammation takes hold.
authors: National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA. Electronic address: Wstrober@niaid.nih.gov.
authors: Warren
authors: W
authors: Strober
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology*; D064307:Microbiota
keywords: Anti-inflammatory organisms; Gut microbiome; Inflammatory Bowel Disease; Mucosal regulatory T cells; Proinflammatory (colitogenic organisms)
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