title: Chronic paracoccidioidomycosis of the intestine as single organ involvement points to an alternative pathogenesis of the mycosis.
abstract: Current knowledge on the natural history of paracoccidioidomycosis states that the chronic form of the disease results from reactivation of quiescent foci established years or decades before during the primary lung infection. Once reactivated, the fungi can disseminate to virtually any organ or system. We present herein two chronic paracoccidioidomycosis patients with a single organ involvement that points to an alternative pathogenesis of the mycosis. These patients suggest that the chronic form may also arise from reactivation of foci not confined to the lungs, due to the early dissemination of yeast cells during the primary infection.
authors: Laboratory of Medical Investigation Units 56 and 53, Clinics Hospital and Laboratory of Medical Mycology, Tropical Medicine Institute, University of São Paulo Medical School, Av Dr. Eneas de Carvalho Aguiar 470, São Paulo, CEP 05403-000, Brazil, bengil60@gmail.com.
authors: G
authors: G
authors: Benard
authors: A N
authors: AN
authors: Costa
authors: A P S
authors: AP
authors: Leopércio
authors: A P
authors: AP
authors: Vicentini
authors: A
authors: A
authors: Kono
authors: M A
authors: MA
authors: Shikanai-Yasuda
mesh_terms: D003113:Colonoscopy; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007410:Intestinal Diseases / Q000382:microbiology* / Q000473:pathology*; D007422:Intestines / Q000473:pathology; D008168:Lung / Q000000981:diagnostic imaging; D008853:Microscopy; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000473:pathology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
references: Semin Respir Crit Care Med. 2011 Dec;32(6):764-74
references: 22167404
references: Mycopathologia. 2008 Apr-May;165(4-5):209-21
references: 18777630
references: Rev Soc Bras Med Trop. 1987 Apr-Jun;20(2):129-32
references: 3507739
references: Lancet. 2000 Dec 23-30;356(9248):2133-8
references: 11191539
references: Clinics (Sao Paulo). 2013 Apr;68(4):441-8
references: 23778339
references: J Infect Dis. 2012 Oct;206(8):1194-205
references: 22732919
references: Am J Trop Med Hyg. 2011 Sep;85(3):546-50
references: 21896820
references: Rev Hosp Clin Fac Med Sao Paulo. 1976 May-Jun;31(3):199-207
references: 935723
references: Hospital (Rio J). 1966 Jan;69(1):169-74
references: 5295601
references: J Clin Gastroenterol. 2011 Feb;45(2):87-91
references: 20975575
references: Clin Microbiol Rev. 2011 Apr;24(2):296-313
references: 21482727