title: The maize leaf lipidome shows multilevel genetic control and high predictive value for agronomic traits.
abstract: Although the plant lipidome show an enormous level of structural and functional diversity, our knowledge about its genetic control and its connection to whole-plant phenotypes is very limited. Here, we profiled 563 lipid species with UPLC-FT-MS in 289 field-grown inbred lines genotyped with 56,110 SNPs. Genome-wide association study identified 174 associations for 76 lipids explaining up to 31.4% of the genetic variance (P-value 8.4 × 10(-18)). Candidate genes were found for lipid synthesis, breakdown, transfer, and protection against peroxidation. The detected SNP-lipid associations could be grouped into associations with 1) individual lipids, 2) lipids from one biochemical class, and 3) lipids from several classes, suggesting a multilevel genetic control architecture. We further found a strong connection between the lipidome and agronomic traits in field-evaluated hybrid progeny. A cross-validated prediction model yielded correlations of up to 0.78 suggesting that the lipidome accurately predicts agronomic traits relevant in hybrid maize breeding.
authors: Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, Fruwirthstr. 21, 70593 Stuttgart, Germany.
authors: Christian
authors: C
authors: Riedelsheimer
authors: Yariv
authors: Y
authors: Brotman
authors: Michaël
authors: M
authors: Méret
authors: Albrecht E
authors: AE
authors: Melchinger
authors: Lothar
authors: L
authors: Willmitzer
mesh_terms: D018745:Genome, Plant / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000235:genetics*; D018515:Plant Leaves / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D003313:Zea mays / Q000235:genetics*
chemical_list: D008055:Lipids
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