title: Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.
abstract: 2-Amino-1,4-dihydropyrimidines were reacted with bis-electrophiles to produce novel fused bi-pyrimidine, pyrimido-aminotriazine, and pyrimido-sulfonamide scaffolds. In addition, a quinazoline library was constructed using a guanidine Atwal-Biginelli reaction with 1-(quinazolin-2-yl)guanidines. The product heterocycles have novel constitutions with high nitrogen atom counts and represent valuable additions to screening libraries for the discovery of new modulators of biological targets.
authors: University of Pittsburgh, Center for Chemical Methodologies and Library Development, Pittsburgh, PA 15260, USA.
authors: David M
authors: DM
authors: Arnold
authors: Matthew G
authors: MG
authors: Laporte
authors: Shelby M
authors: SM
authors: Anderson
authors: Peter
authors: P
authors: Wipf
keywords: Atwal-Biginelli reaction; Guanidines; Pyrimidines; Quinazolines; Screening library
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