title: An RNA modification with remarkable resistance to RNase A.
abstract: A 3'-deoxy-3'-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. The most remarkable finding is that, despite the fact that both the vicinal 2-hydroxy nucleophile and the 5'-oxyanion leaving group are intact, the 3'-methylenephosponate RNA modification is also highly resistant towards the action of RNase A.
authors: Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen 7, 14183, Huddinge, Sweden. Roger.Stromberg@ki.se.
authors: Alice
authors: A
authors: Ghidini
authors: Charlotte
authors: C
authors: Ander
authors: Anna
authors: A
authors: Winqvist
authors: Roger
authors: R
authors: Strömberg
mesh_terms: D009843:Oligoribonucleotides / Q000737:chemistry*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010757:Phosphorous Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D012910:Snake Venoms / Q000201:enzymology
chemical_list: D009843:Oligoribonucleotides; D010757:Phosphorous Acids; D012910:Snake Venoms; D012313:RNA; D012259:Ribonuclease, Pancreatic; D010727:Phosphoric Diester Hydrolases