title: Gut sensing of potassium intake and its role in potassium homeostasis.
abstract: Extracellular K(+) homeostasis has been explained by feedback mechanisms in which changes in extracellular K(+) concentration drive renal K(+) excretion directly or indirectly via stimulating aldosterone secretion. However, this cannot explain meal-induced kaliuresis, which often occurs without increases in plasma K(+) or aldosterone concentrations. Recent studies have produced evidence supporting a feedforward control in which gut sensing of dietary K(+) increases renal K(+) excretion (and extrarenal K(+) uptake) independent of plasma K(+) concentrations, namely, a gut factor. This review focuses on these new findings and discusses the role of gut factor in acute and chronic regulation of extracellular K(+) as well as in the beneficial effects of high K(+) intake on the cardiovascular system.
authors: Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, CA 90089-9142, USA. youn@usc.edu
authors: Jang H
authors: JH
authors: Youn
mesh_terms: D000818:Animals; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D017419:Potassium, Dietary / Q000378:metabolism*
chemical_list: D005768:Gastrointestinal Hormones; D007328:Insulin; D017419:Potassium, Dietary; D011188:Potassium
keywords: Potassium excretion; feedback control; feedforward control; potassium adaptation; potassium balance
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