title: Cancer problem in Peutz-Jeghers syndrome.
abstract: Peutz-Jeghers syndrome is a rare autosomal dominantly inherited condition, characterized by the presence of hamartomatous gastrointestinal polyps and mucocutaneous pigmentation. Patients with this syndrome can be associated with other neoplasms such as ovarian neoplasms known as sex-cord tumor with annular tubules that are associated in one third of the cases with this syndrome and other types of malignancies. We report a 42-year-old woman with a history of Peutz-Jeghers Syndrome and bilateral breast cancer that presented with abnormal uterine bleeding. Total abdominal hysterectomy with bilateral salpino-oophorectomy was done and an ovarian sex cord tumor with annular tubules was incidentally diagnosed. By reviewing literatures and in agreement with previous studies we suggest routine screening for malignancies in patients with Peutz-Jeghers syndrome.
authors: Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Diana
authors: D
authors: Taheri
authors: Noushin
authors: N
authors: Afshar-Moghadam
authors: Parvin
authors: P
authors: Mahzoni
authors: Amin
authors: A
authors: Eftekhari
authors: Seyed Mozafar
authors: SM
authors: Hashemi
authors: Mohammad Hasan
authors: MH
authors: Emami
authors: Mehdi
authors: M
authors: Fesharakizadeh
authors: Hamid Reza
authors: HR
authors: Ghasemi-Basir
keywords: Breast cancer; Peutz–Jeghers syndrome; ovarian cancer; sex cord tumor
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