title: Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.
abstract: Excessive obesity correlates with hypersomnolence and impaired cognitive function, presumably induced by metabolic factors and cytokines. Production of the adipokine leptin correlates with the amount of adiposity, and leptin has been shown to promote sleep. To determine whether leptin plays a major role in the hypersomnolence of obesity, we measured sleep architecture in pan-leptin receptor knockout (POKO) mice that do not respond to leptin because of the production of a mutant, non-signaling receptor. The obese POKO mice had more non-rapid eye movement (NREM) sleep and less waking time than their littermate controls. This was mainly seen during the light span, although increased bouts of rapid eye movement sleep were also seen in the dark span. The increase of NREM sleep correlated with the extent of obesity. The POKO mice also had decreased locomotor activity and more immobility in the open field test, but there was no increase of forced immobility nor reduction of sucrose intake as would be seen in depression. The increased NREM sleep and reduced locomotor activity in the POKO mice suggest that it was obesity, rather than leptin signaling, that played a predominant role in altering sleep architecture and activity.
authors: Blood-Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors: Yuping
authors: Y
authors: Wang
authors: Junyun
authors: J
authors: He
authors: Abba J
authors: AJ
authors: Kastin
authors: Hung
authors: H
authors: Hsuchou
authors: Weihong
authors: W
authors: Pan
mesh_terms: D000818:Animals; D006970:Disorders of Excessive Somnolence / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity; D009765:Obesity / Q000150:complications / Q000235:genetics; D054411:Receptors, Leptin / Q000235:genetics*; D012895:Sleep, REM; D014851:Wakefulness
chemical_list: D054411:Receptors, Leptin
references: J Neuroinflammation. 2012 May 11;9:91
references: 22578011
references: Sleep Med Rev. 2014 Jun;18(3):283-90
references: 24080454
references: Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1158-65
references: 10827020
references: Sleep. 2000 Dec 15;23(8):1025-40
references: 11145318
references: J Mol Neurosci. 2011 Mar;43(3):478-84
references: 21086065
references: Peptides. 2008 Oct;29(10):1732-9
references: 18577407
references: Behav Brain Res. 2010 Dec 1;213(2):319-22
references: 20438766
references: J Mol Neurosci. 2012 Feb;46(2):276-84
references: 21598024
references: Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R2059-66
references: 18843095
references: Behav Brain Res. 2009 Dec 28;205(2):349-54
references: 19591880
references: J Mol Neurosci. 2013 May;50(1):124-33
references: 22956188
references: Life Sci. 2001 May 4;68(24):2705-14
references: 11400913
references: Psychopharmacology (Berl). 2010 Jan;207(4):535-45
references: 19823809
references: Brain Behav Immun. 2010 Nov;24(8):1340-6
references: 20600810
references: Brain. 2009 Apr;132(Pt 4):889-902
references: 19293246
references: Clin Chest Med. 2003 Jun;24(2):249-59
references: 12800782
references: Obesity (Silver Spring). 2007 Oct;15(10):2504-11
references: 17925477
references: Peptides. 1996;17(2):305-11
references: 8801538
references: Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R894-903
references: 16293682
references: Neuropharmacology. 2001 May;40(6):818-25
references: 11369035
references: Sleep. 2012 May 01;35(5):605-15
references: 22547886
references: J Appl Physiol (1985). 2013 Oct 1;115(7):995-1003
references: 23869060
references: J Appl Physiol (1985). 1998 Jan;84(1):253-6
references: 9451643
references: Arch Intern Med. 1998 Jun 22;158(12):1333-7
references: 9645828
references: Sleep. 2011 Oct 01;34(10):1335-45
references: 21966065
references: Physiol Behav. 2006 Feb 28;87(2):255-62
references: 16360185
references: J Neurosci Methods. 2004 Feb 15;133(1-2):71-80
references: 14757347
references: Am J Physiol. 1989 Jan;256(1 Pt 2):R281-3
references: 2912222
references: Sleep. 2003 May 1;26(3):298-307
references: 12749549
references: J Appl Physiol (1985). 2012 Apr;112(8):1410-8
references: 22323652
references: J Sleep Res. 1999 Sep;8(3):197-203
references: 10476006
references: J Appl Physiol (1985). 2013 Mar 15;114(6):734-41
references: 23329815
references: Ann N Y Acad Sci. 2012 Aug;1264:64-71
references: 22530983
references: Psychoneuroendocrinology. 2011 Feb;36(2):266-78
references: 20724079