title: [Regulating pre-antral follicle development: a brake on depletion of the ovarian reserve].
abstract: The process of folliculogenesis is a complex and dynamic process that is regulated by positive and negative factors. During folliculogenesis in the mammalian ovary, the primordial follicle pool is gradually reduced through successive waves of follicle growth. It is important that this pool is carefully regulated, otherwise premature ovarian failure will occur. This process results in the ovulation of an ovocyte or more commonly, the loss of ovocytes through atresia. The majority of research has concentrated on the positive regulators of follicle growth with very little attention on the negative regulators. Nonetheless, there are several factors that have been observed to inhibit follicle activation and development. In this review, we summarize those here.
authors: INRA, UMR85, physiologie de la reproduction et des comportements, 37380 Nouzilly, France. jMichael.Bertoldo@tours.inra.fr
authors: M-J
authors: MJ
authors: Bertoldo
authors: J
authors: J
authors: Bernard
authors: N
authors: N
authors: Duffard
authors: P
authors: P
authors: Mermillod
authors: Y
authors: Y
authors: Locatelli
mesh_terms: D028341:Activins / Q000502:physiology; D000818:Animals; D054304:Anti-Mullerian Hormone / Q000502:physiology; D005260:Female; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology; D006080:Ovarian Follicle / Q000254:growth & development*; D010053:Ovary / Q000502:physiology*; D010060:Ovulation; D016649:Primary Ovarian Insufficiency / Q000209:etiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: C422405:activin A; D028341:Activins; D054304:Anti-Mullerian Hormone; D048031:JNK Mitogen-Activated Protein Kinases
keywords: AMH; C-Jun; Folliculogenesis; Folliculogenèse; Ovocyte