title: [Incidence and clinical outcome of contrast-induced nephropathy in the elderly patients].
abstract: BACKGROUND
  Aging is an established risk factor for contrast-induced nephropathy (CIN). However, little information is available on the incidence and clinical outcome of CIN for the elderly patients in Japan.
  
  
  OBJECTIVE
  We determined the incidence and clinical outcome of CIN in the Japanese elderly patient.
  
  
  METHODS
  We studied 292 patients who had mild renal dysfunction (estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)) at baseline and underwent coronary angiography. Patients were divided into two groups base on their age: the elderly group (age ≥ 75, n=108) and the control group (age<75, n=184). CIN was defined as a 25% increase in serum creatinine or an increase in serum creatinine by>0.5 mg/dl above the baseline value at or within 2 days post procedure.
  
  
  RESULTS
  Patients in the elderly group had a higher incidence of CIN (14%) than those in the control group (9%). In patients who developed CIN, there was no significant difference between the two groups in baseline GFR and GFR on days 1, 2, 7 and 30 after the procedure. However, the relative increase in GFR above baseline on day 7 (-4.0 ± 6.1 vs -8.3 ± 8.0 ml/min P=0.096) and day 30 (1.5 ± 9.4 vs -10.1 ± 9.6 ml/min P=0.0017) in the elderly group was higher than that in the control group. Furthermore, death occurred in 3 patients in the elderly group (20%) whereas no patient died in the control group (P=0.092).
  
  
  CONCLUSIONS
  Aging (age ≥ 75) is a risk factor for CIN in Japanese. CIN in the elderly patients may be associated with prolonged renal dysfunction and poor prognosis.
authors: Department of Medicine II, Kansai Medical University.
authors: Masayuki
authors: M
authors: Motohiro
authors: Hiroshi
authors: H
authors: Kamihata
authors: Yoshinori
authors: Y
authors: Suwa
authors: Kousuke
authors: K
authors: Murakawa
authors: Satoshi
authors: S
authors: Tsujimoto
authors: Shigeo
authors: S
authors: Umemura
authors: Kenichi
authors: K
authors: Manabe
authors: Toshiji
authors: T
authors: Iwasaka
authors: Ichiro
authors: I
authors: Shiojima
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000401:mortality; D007677:Kidney Function Tests; D008297:Male; D011379:Prognosis
chemical_list: D003287:Contrast Media