title: Big endothelin-1 and nitric oxide in hypertensive elderly patients with and without obstructive sleep apnea-hypopnea syndrome.
abstract: BACKGROUND
  The role of oxidative stress in hypertensive elderly patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) is unknown.
  
  
  OBJECTIVE
  The purpose was to evaluate the levels of big endothelin-1 (Big ET-1) and nitric oxide (NO) in elderly hypertensive patients with and without moderate to severe OSAHS.
  
  
  METHODS
  Volunteers were hospitalized for 24 h. We obtained the following data: body mass index (BMI); 24-ambulatory blood pressure monitoring; and current medication. Arterial blood was collected at 7 pm and 7 am for determining plasma NO and Big ET-1 levels. Pulse oximetry was performed during sleep. Pearson's or Spearman's correlation and univariate analysis of variance were used for statistical analysis.
  
  
  RESULTS
  We studied 25 subjects with OSAHS (group 1) and 12 without OSAHS (group 2) aged 67.0 ± 6.5 years and 67.8 ± 6.8 years, respectively. No significant differences were observed between the groups in BMI; number of hours of sleep; 24-h systolic and diastolic BPs; awake BP, sleep BP and medications to control BP between groups. No differences were detected in plasma Big ET-1 and NO levels at 19:00 h, but plasma Big ET-1 levels at 7:00 h were higher in group 1 (p =0.03). In group 1, a negative correlation was also observed between the mean arterial oxyhemoglobin saturation level, 24-h systolic BP (p = 0.03, r = -0.44), and Big ET-1 (p = 0.04, r = -0.41).
  
  
  CONCLUSIONS
  On comparing elderly hypertensive patients with and without OSAHS having similar BP and BMI, we observed higher Big ET-1 levels After sleep in the OSAHS group. NO levels did not differ between the hypertensive patients with or without OSAHS.
authors: Iara Felicio
authors: IF
authors: Anunciato
authors: Rômulo Rebouças
authors: RR
authors: Lobo
authors: Eduardo Barbosa
authors: EB
authors: Coelho
authors: Waldiceu Aparecido
authors: WA
authors: Verri
authors: Alan Luiz
authors: AL
authors: Eckeli
authors: Paulo Roberto Barbosa
authors: PR
authors: Evora
authors: Fernando
authors: F
authors: Nobre
authors: Júlio César
authors: JC
authors: Moriguti
authors: Eduardo
authors: E
authors: Ferriolli
authors: Nereida Kilza da Costa
authors: NK
authors: Lima
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D010092:Oximetry; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000503:physiopathology; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide
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