title: [Vitamin D deficiency in Germany, is it a danger for increased morbidityand mortality?].
abstract: Vitamin D regulates the calcium-phosphate metabolism and thereby plays an important role for the integrity and functioning of bone, muscle and nerves. Studies have shown furthermore an influence on certain types of cancer, diabetes and cardiovascular diseases. Vitamin D is mainly produced by the skin. During exposure to sunlightthe precursor7-dehydrocholesterol is transformed to colecalciferol (vitamin D3). Smaller amounts are supplied by nutrition. In our latitude vitamin D synthesis takes only place during summertime. The vitamin stored in fat tissue in generally is not sufficient for the whole winter period and accordingly insufficiency is very frequent. In a cross-sectional study all over Germany (DeViD, 2007) only about 8% of the population was vitamin D sufficient in spring time.Two prospective studies (2008) proved a correlation between vitamin D supply and overall mortality. An amelioration of vitamin D supply can be achieved either by increasing sun exposure or daily oral intake of 800-2000 IU (=20-50 microg) colecalciferol.
authors: Klinikum Leverkusen gGmbH, Leverkusen.
authors: J D
authors: JD
authors: Ringe
authors: C
authors: C
authors: Kipshoven
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002762:Cholecalciferol / Q000172:deficiency* / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D018570:Risk Assessment; D012621:Seasons; D012737:Sex Factors; D013223:Statistics as Topic; D014808:Vitamin D Deficiency / Q000401:mortality* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D002762:Cholecalciferol