title: Haplotypes of the IL10 gene as potential protection factors in leprosy patients.
abstract: Leprosy is an infectious disease caused by Mycobacterium leprae characterized by dermatoneurological signs and symptoms that has a large number of new cases worldwide. Several studies have associated interleukin 10 with susceptibility/resistance to several diseases. We investigated haplotypes formed by three single nucleotide polymorphisms (SNPs) located in the IL10 gene (A-1082G, C-819T, and C-592A) in order to better understand the susceptibility to and severity of leprosy in an admixed northern Brazil population, taking into account estimates of interethnic admixture. We observed the genotypes ACC/ACC (P = 0.021, odds ratio [OR] [95% confidence interval (CI)] = 0.290 [0.085 to 0823]) and ACC/GCC (P = 0.003, OR [95% CI] = 0.220 [0.504 to 0.040]) presenting significant results for protection against leprosy development, framed in the profiles of low and medium interleukin production, respectively. Therefore, we suggest that genotypes A-1082G, C-819T, and C-592A formed by interleukin-10 polymorphisms are closely related to protection of the leprosy development in an admixed northern Brazil population, in particular ACC/ACC and ACC/GCC genotypes.
authors: Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.
authors: Patricia
authors: P
authors: Garcia
authors: Dayse
authors: D
authors: Alencar
authors: Pablo
authors: P
authors: Pinto
authors: Ney
authors: N
authors: Santos
authors: Claudio
authors: C
authors: Salgado
authors: Vinicius A
authors: VA
authors: Sortica
authors: Mara H
authors: MH
authors: Hutz
authors: Ândrea
authors: Â
authors: Ribeiro-dos-Santos
authors: Sidney
authors: S
authors: Santos
mesh_terms: D000328:Adult; D001938:Brazil; D060467:Disease Resistance; D005260:Female; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology*; D007918:Leprosy / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
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