title: Glycine receptor α2 subunit activation promotes cortical interneuron migration.
abstract: Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis.
authors: Department of Cell Physiology, BIOMED Research Institute, Hasselt University, Diepenbeek 3590, Belgium.
authors: Ariel
authors: A
authors: Avila
authors: Pía M
authors: PM
authors: Vidal
authors: T Neil
authors: TN
authors: Dear
authors: Robert J
authors: RJ
authors: Harvey
authors: Jean-Michel
authors: JM
authors: Rigo
authors: Laurent
authors: L
authors: Nguyen
mesh_terms: D000200:Action Potentials; D000205:Actomyosin / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D007395:Interneurons / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018009:Receptors, Glycine / Q000235:genetics / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; C501173:Glra2 protein, mouse; D018009:Receptors, Glycine; D000205:Actomyosin; D002118:Calcium; D005998:Glycine
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