title: In vitro susceptibility of Conidiobolus lamprauges recovered from sheep to antifungal agents.
abstract: Data regarding the susceptibility of Conidiobolus lamprauges is limited and there is no consensus about the optimal treatment for infections caused by Conidiobolus spp. In this context, the objective of this study was to evaluate the in vitro susceptibility of six C. lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. Terbinafine was the most active (MIC range <0.06-0.5 μg/mL). Resistance or reduced susceptibility was observed for amphotericin B and azole and echinocandin antifungals. Additional studies are necessary to determine the therapeutic potential of terbinafine as monotherapy or in combination therapy with other antifungals.
authors: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Brazil.
authors: Juliana Simoni Moraes
authors: JS
authors: Tondolo
authors: Érico Silva
authors: ÉS
authors: de Loreto
authors: Valéria
authors: V
authors: Dutra
authors: Luciano
authors: L
authors: Nakazato
authors: Daphine Ariadne Jesus
authors: DA
authors: de Paula
authors: Régis Adriel
authors: RA
authors: Zanette
authors: Sydney Hartz
authors: SH
authors: Alves
authors: Janio Morais
authors: JM
authors: Santurio
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D020092:Conidiobolus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000382:microbiology*; D020096:Zygomycosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000935:Antifungal Agents
keywords: Conidiobolomycosis; Susceptibility testing; Terbinafine