title: Chronic inflammation and gallbladder cancer.
abstract: Gallbladder cancer (GBC) is the most common biliary tract malignancy with an extremely poor prognosis. Epidemiological data have demonstrated that chronic inflammation resulting from infection of gallbladder or gallstones predispose individuals to GBC. Recent studies have begun to elucidate molecular mechanisms underlying the development of GBC in the setting of chronic inflammation. It is possible that persistently local inflammatory reactions may contribute to the development and progression of GBC through inducing genetic alterations, and subsequent promoting survival and proliferation of mutated sells, inhibiting apoptosis, stimulating angiogenesis and metastasis. This article reviews the current understanding of the involvement of chronic inflammation in gallbladder tumorigenesis.
authors: The Second Hospital of Lanzhou University, Lanzhou 730030, China; Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China. Electronic address: liym@lzu.edu.cn.
authors: Yumin
authors: Y
authors: Li
authors: The Second Hospital of Lanzhou University, Lanzhou 730030, China; Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730030, China.
authors: Junqiang
authors: J
authors: Zhang
authors: The First Hospital of Lanzhou University, Lanzhou 730000, China.
authors: Haizhen
authors: H
authors: Ma
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism; D002761:Cholangitis / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D002908:Chronic Disease; D018450:Disease Progression; D005706:Gallbladder Neoplasms / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D018836:Inflammation Mediators
keywords: Aetiology; Chronic inflammation; Gallbladder cancer; Pathogenesis