title: Comparative studies of apoptosis in Xenopus laevis and mouse thymoma cell lines.
abstract: With the use of in vitro methods and cell lines, functional aspects of apoptosis in the Xenopus laevis B3/B7 and mouse EL4 thymoma cell lines are revealed. Moreover, by using information gleaned from digital imaging and immunocytochemistry, changes in locations of key proteins implicated in apoptotic anti-cancer responses, e.g. p53 and Mdm2, are shown. Suggestions are offered as to what these results might mean with respect to the evolutionary conservation of the function and structure of these two molecules and to cancer resistance in amphibians. Finally, studies are described on resveratrol as an anti-cancer therapeutic reagent in the two thymoma cell lines and in normal X. laevis thymocytes.
authors: Reed College, Portland, OR, USA.
authors: Rachel O
authors: RO
authors: Johnson
authors: Thomas V
authors: TV
authors: Tittle
authors: Maria P M
authors: MP
authors: Sefchick
authors: Leslie D
authors: LD
authors: Zettergren
authors: Laurens N
authors: LN
authors: Ruben
authors: Richard H
authors: RH
authors: Clothier
authors: Michael
authors: M
authors: Balls
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D007150:Immunohistochemistry; D051379:Mice; D051736:Proto-Oncogene Proteins c-mdm2 / Q000032:analysis; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013945:Thymoma / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014466:Ultraviolet Rays; D014982:Xenopus laevis
chemical_list: D013267:Stilbenes; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2; D000077185:Resveratrol