title: Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues.
abstract: A new series of 1-adamantyl derivatives was designed, synthesized and evaluated for their antimicrobial and antiviral activities. Representative derivatives of the newly synthesized compounds were tested. Ampicillin, clotimazole and the antiviral antibiotic aphidicolin were used as positive controls. Compound 18 proved to be the most active member of this series as antimicrobial against Staphylococcus aureus and Candida albicans and as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.02 mg/ml while compound 19 proved to be the most active member of this series as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.01 mg/ml.
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Ghada S
authors: GS
authors: Hassan
authors: Ali A
authors: AA
authors: El-Emam
authors: Laila M
authors: LM
authors: Gad
authors: Alaa Eldin M
authors: AE
authors: Barghash
keywords: 1-Adamantyl; Antimicrobial testing; Antiviral screening; Synthesis
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