title: Frequency of cancer in first-degree relatives of patients with cleft lip and/or palate in the Brazilian population.
abstract: Congenital malformations and cancer may share common etiological factors and the association between nonsyndromic cleft lip and/or palate (NSCL/P) and cancers has been observed in different studies. The objective of this study was to evaluate the frequency of cancer in relatives of patients with NSCL/P. This investigation was a cross-sectional, case-controlled study, evaluating 358 patients with NSCL/P treated at a Referral Center for craniofacial deformities (case group) and 358 patients without craniofacial alterations (control group). Information concerning the gender, age and family history of cancer in first-degree relatives for both groups was obtained. The frequency of cancer was 6.4% (n=46) in the studied population, with 18 subjects in the case group (5%) and 28 (7.8%) in control. In both groups, the most frequently reported cases were those of breast, colorectal, stomach, prostate and uterus cancers, but there was no association between the two groups. There was no association with a family history of cancer among the first-degree relatives (odds ratio=0.62; 95% IC: 0.34 to 1.15), neither when the analysis was made by type of cancer. In conclusion, both epidemiological and genetic studies have suggested common etiological factors for NSCL/P and cancer. However, in this population-based study, no association between cancer and NSCL/P could be confirmed.
authors: Health Science Program, State University of Montes Claros, Montes Claros, MG, Brazil.
authors: Leonardo Santos
authors: LS
authors: Lima
authors: Matheus de Oliveira
authors: Mde O
authors: Silvério
authors: Mário Sérgio Oliveira
authors: MS
authors: Swerts
authors: Sibele Nascimento de
authors: SN
authors: Aquino
authors: Daniella Reis Barbosa
authors: DR
authors: Martelli
authors: Hercílio
authors: H
authors: Martelli-Júnior
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D002971:Cleft Lip / Q000453:epidemiology* / Q000235:genetics; D002972:Cleft Palate / Q000453:epidemiology* / Q000235:genetics; D015179:Colorectal Neoplasms / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology; D055815:Young Adult