title: Living donor transplant options in end-stage renal disease patients with ABO incompatibility.
abstract: BACKGROUND
  The options available to CKD 5 patients with donor shortage due to incompatibilities is to either get enlisted in cadaver transplant program or opt for three other alternatives viz; ABO-incompatible transplant (ABO-I), ABO-incompatible transplant with Rituximab (ABO-R) or paired-kidney exchange transplant (PKE). At our institute we have performed ABO-I, ABO-R and PKE transplants and we are presenting the results of these transplants performed at our institution. Here, we report our experiences of living donor kidney transplantation in highly sensitized patients.
  
  
  OBJECTIVE
  To review the options available to CKD 5 patients with incompatible donor.
  
  
  METHODS
  Between January 2008 and June 2011, 7 PKE, 26 ABO-I and 7 ABO-R transplants were carried out at our institute. Evaluation of both the recipients and donors involved biochemical, serological and radiological investigations. In case of PKE, recipients were operated simultaneously in different operation theaters. In ABO-I splenectomy was done while in ABO-R was given. Post-transplant the recipient management protocol remained the same. Expenditure following each transplant was calculated.
  
  
  RESULTS
  The graft and patient survival of ABO-I, ABO-R and PKE transplants 12-18 months after transplant were 78.9%:80%, 85.7%:85.7% and 100%:100%, respectively.
  
  
  CONCLUSIONS
  The inclusion of Rituximab in the transplant protocol appears promising. The existing donor shortage could be addressed by encouraging other options like PKE. The limiting factor for ABO-R and PKE transplants is time and cost, respectively. The decision depends on the informed consent between the patient and the nephrologists.
authors: Department of Urology and Renal Transplant, Jaslok Hospital and Research Centre, Mumbai, India.
authors: Santosh S
authors: SS
authors: Waigankar
authors: Madhav H
authors: MH
authors: Kamat
authors: Shriram
authors: S
authors: Joshi
authors: Bhupendra V
authors: BV
authors: Gandhi
authors: Madan
authors: M
authors: Bahadur
authors: Rushi V
authors: RV
authors: Deshpande
keywords: ABO incompatibility; CKD 5; Rituximab; living donor; paired-kidney exchange transplants; splenectomy
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