title: Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: a retrospective cohort study.
abstract: To compare the rates of cure of septic abortion and pelvic inflammatory disease using a daily dose of clindamycin with gentamicin versus divided doses, we conducted a retrospective cohort study, where the electronic records of 661 patients who used clindamycin 1 × , 3 × or 4 ×/day (groups 1, 3 and 4, respectively) between September 2002 and August 2010 were analysed. Major outcomes included rates of cure and failure according to the clinical records. Secondary endpoints were percentage of adverse effects related to medication regimen and the prevalence of positive VDRL and HIV. Similar conditions were observed in all groups - septic abortion: 167/116/123; pelvic inflammatory disease: 73/95/87 (groups 1, 3 and 4, respectively). No significant difference was found among groups for age or for rate of cure. Rates of cure (cure/total [rate (95%CI)]) in groups 1, 3 and 4 were 236/240 [0.983 (0.957-0.993)], 205/211 [0.971 (0.939-0.986)], 203/210 [0.966 (0.932-0.983)], respectively. Days of use of clindamycin was significantly reduced in group 1, compared to groups 3 and 4 (2.6 ± 1.3 vs. 3.5 ± 2.5 vs. 3.3 ± 1.9-mean ± SD; p < 0.0001 - ANOVA), but this may be due to differences in how length of therapy was measured and not the effect on clinical cure.
authors: Departamento e Serviço de Ginecologia e Obstetrícia, Universidade Federal do Rio Grande do Sul - Hospital de Clínicas de Porto Alegre - Rua Ramiro Barcelos, Porto Alegre, Brazil.
authors: Cláudia S
authors: CS
authors: Giugno
authors: Alice L
authors: AL
authors: Silva
authors: Daniele G
authors: DG
authors: Fuhrich
authors: Paola S
authors: PS
authors: Rabaioli
authors: Katia G
authors: KG
authors: Gonçalves
authors: Nicole C
authors: NC
authors: Sartor
authors: Ricardo F
authors: RF
authors: Savaris
mesh_terms: D000031:Abortion, Septic / Q000188:drug therapy*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002981:Clindamycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay; D008499:Medical Records; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin
keywords: PID; Septic abortion; antibiotics; clindamycin; dose; gentamicin; pelvic inflammatory disease; sexually transmitted infection; treatment