title: Organometalliccis-Dichlorido Ruthenium(II) Ammine Complexes.
abstract: Bifunctional neutral half-sandwich RuIIcomplexes of the type [(η6-arene)Ru(NH3)Cl2] where arene isp-cym (1) or bip (2) were synthesised by the reaction ofN,N-dimethylbenzylamine (dmba), NH4PF6and the corresponding RuIIarene dimer, and were fully characterised. X-ray crystallographic studies of [(η6-p-cym)Ru(NH3)Cl2]·{(dmba-H)(PF6)} (1a) and [(η6-bip)Ru(NH3)Cl2] (2) show extensive H-bond interactions in the solid state, mainly involving the NH3and the Cl ligands, as well as weak aromatic stacking interactions. The half-lives for the sequential hydrolysis of1and2determined by UV/Vis spectroscopy at 310 K ranged from a few minutes for the first aquation to ca. 45 min for the second aquation; the diaqua adducts were the predominant species at equilibrium. Arene loss during the aquation of complex2was observed. Upon hydrolysis, both complexes readily formed mono- and di-9-ethylguanine (9-EtG) adducts in aqueous solution at 310 K. The reaction reached equilibrium after ca. 1.8 h in the case of complex1and was slower but more complete for complex2(before the onset of arene loss at ca. 2.7 h). Complexes1and2were not cytotoxic towards A2780 human ovarian cancer cells up to the maximum concentration tested (100 μM).
authors: Department of Chemistry, University of Warwick Coventry, CV4 7AL, UK E-mail: P.J.Sadler@warwick.ac.uk.
authors: Soledad
authors: S
authors: Betanzos-Lara
authors: Abraha
authors: A
authors: Habtemariam
authors: Guy J
authors: GJ
authors: Clarkson
authors: Peter J
authors: PJ
authors: Sadler
keywords: Antitumor agents; Arene ligands; Cytotoxicity; N ligands; Ruthenium; Sandwich complexes
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