title: Sustained antidepressant response to ketamine.
abstract: Case series outlining the treatment of three patients with ketamine, in which two of the patients had a sustained antidepressant effect to ketamine without the need for maintenance on antidepressants. These two responders have an established diagnosis of bipolar affective disorder with a history of response to electroconvulsive therapy and lithium, both of which have an influence on the seizure threshold as has ketamine. The mechanism of action of ketamine is yet unclear and although the current focus is on the N-methyl-d-aspartate and alpha-amino-3-4-hydroxy-5methyl-4-isoxazoleproprionic acid receptors, we additionally recommend that its impact on the seizure threshold should be explored with a view to fully elucidating the mechanism of action.
authors: Department of Psychiatry (Hergest Unit), Ysbyty Gwynedd Hospital, Bangor, Wales, UK.
authors: Onome Victor
authors: OV
authors: Atigari
authors: David
authors: D
authors: Healy
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000627:therapeutic use*; D008875:Middle Aged; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine
references: Aust N Z J Psychiatry. 2013 Nov;47(11):998-1001
references: 23798716
references: Biol Psychiatry. 2013 Aug 15;74(4):257-64
references: 23206319
references: Clin Pharmacol Ther. 2012 Feb;91(2):303-9
references: 22205190
references: Neuropsychopharmacology. 2013 Apr;38(5):729-42
references: 23303054
references: Biol Psychiatry. 2000 Feb 15;47(4):351-4
references: 10686270