title: Flavonoids from Sudanese Albizia zygia (Leguminosae, subfamily Mimosoideae), a plant with antimalarial potency.
abstract: Three flavonoids were isolated for the first time from the Sudanese medicinal plants Albizia zygia. Compounds 1-3 were identified by interpretation of ESI mass data, (1)H, (13)C and 2D NMR as well as by comparison with published data as 4',7-dihydroxyflavanone (1) 3',4',7-trihydroxyflavone (2), 3-O-methylfisetin (3',4',7-trihydroxy-3-methoxyflavone, 3). All flavonoids were tested against Plasmodium falciparum, and only compound 2 showed high antimalarial activity (IC50 0.078 µg/ml).
authors: Institute of Organic and Biomolecular Chemistry, Georg-August University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors: Muna Ali
authors: MA
authors: Abdalla
authors: Hartmut
authors: H
authors: Laatsch
mesh_terms: D031289:Albizzia / Q000737:chemistry*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*; D013397:Sudan
chemical_list: C587591:3',4',7-trihydroxyflavone; D000962:Antimalarials; D005419:Flavonoids; D010936:Plant Extracts
keywords: Albizia zygia; Mimosoideae; antimalarial activity; flavonoids
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