title: Effectiveness of one dose of mumps vaccine against clinically diagnosed mumps in Guangzhou, China, 2006-2012.
abstract: Although mumps-containing vaccines were introduced in China in 1990s, mumps continues to be a public health concern due to the lack of decline in reported mumps cases. To assess the mumps vaccine effectiveness (VE) in Guangzhou, China, we performed a 1:1 matched case-control study. Among children in Guangzhou aged 8 mo to 12 y during 2006 to 2012, we matched one healthy child to each child with clinically diagnosed mumps. Cases with clinically diagnosed mumps were identified from surveillance sites system and healthy controls were randomly sampled from the Children's Expanded Programmed Immunization Administrative Computerized System in Guangzhou. Conditional logistic regression was used to calculate VE. We analyzed the vaccination information for 1983 mumps case subjects and 1983 matched controls and found that the overall VE for 1 dose of mumps vaccine, irrespective of the manufacture, was 53.6% (95% confidence interval [CI], 41.0-63.5%) to children aged 8 mo to 12 y. This post-marketing mumps VE study found that immunization with one dose of the mumps vaccine confers partial protection against mumps disease. Evaluation of the VE for the current mumps vaccines, introduction of a second dose of mumps vaccine, and assessment of modifications to childhood immunization schedules is essential.
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Chuanxi
authors: C
authors: Fu
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Jianxiong
authors: J
authors: Xu
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Yuanjun
authors: Y
authors: Cai
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Qing
authors: Q
authors: He
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Chunhuan
authors: C
authors: Zhang
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Jian
authors: J
authors: Chen
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Zhiqiang
authors: Z
authors: Dong
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Wensui
authors: W
authors: Hu
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Hui
authors: H
authors: Wang
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Wei
authors: W
authors: Zhu
authors: Guangzhou Center for Disease Control and Prevention; Guangzhou, PR China.
authors: Ming
authors: M
authors: Wang
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007223:Infant; D008297:Male; D009107:Mumps / Q000628:therapy*; D009108:Mumps Vaccine / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D009108:Mumps Vaccine
keywords: China; children; matched case-control studies; mumps; vaccine effectiveness
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