title: Low frequency mu-like activity characterizes cortical rhythms in epilepsy due to ring chromosome 20.
abstract: OBJECTIVE
  To evaluate the spectral and spatial features of the cortical rhythms in patients affected by ring chromosome 20 - [r(20)]-syndrome.
  
  
  METHODS
  Twelve patients with [r(20)] syndrome were studied. As controls we enrolled 12 patients with idiopathic generalized epilepsy (IGE) and 12 healthy volunteers (HV). Blind source separation, spectral analyses and source reconstruction were applied in all cases in order to identify reliable spatio-temporal patterns of cortical activity.
  
  
  RESULTS
  A theta-delta EEG rhythm was identified in [r(20)] patients, with spectral peak ranging between 3 and 7Hz and whose generators mapped over the sensory-motor cortices. A second peak laying at a frequency about double with respect to the first one was present in 6 cases. Analogue methodological approach in HV and IGE groups failed to show similar findings.
  
  
  CONCLUSIONS
  EEG of [r(20)] patients reveals the existence of a highly reproducible EEG pattern arising from the sensory-motor system.
  
  
  CONCLUSIONS
  The recognition of this peculiar EEG pattern could help the diagnostic work-up. Additionally, our findings supports the existence of a parallelism between this EEG trait and the physiological "mu" rhythm which is generate by the sensory-motor system. Such link suggests a sensory-motor system dysfunction in [r(20)] patients.
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy; Department di Neuroscience, University of Parma, Parma, Italy.
authors: Pietro
authors: P
authors: Avanzini
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy.
authors: Anna Elisabetta
authors: AE
authors: Vaudano
authors: Epilepsy Centre, San Paolo Hospital, Health Science Department, University of Milano, Italy.
authors: Aglaia
authors: A
authors: Vignoli
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy.
authors: Andrea
authors: A
authors: Ruggieri
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy.
authors: Francesca
authors: F
authors: Benuzzi
authors: Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors: Francesca
authors: F
authors: Darra
authors: Pediatric Neurology Unit, V. Buzzi Hospital, A.O. ICP, Milano, Italy.
authors: Massimo
authors: M
authors: Mastrangelo
authors: Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors: Bernardo
authors: B
authors: Dalla Bernardina
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy.
authors: Paolo Frigio
authors: PF
authors: Nichelli
authors: Epilepsy Centre, San Paolo Hospital, Health Science Department, University of Milano, Italy; Department of Medicine, Surgery and Dentistry, Faculty of Medicine and Surgery, University of Milano, Milano, Italy.
authors: Maria Paola
authors: MP
authors: Canevini
authors: Department of Biomedical Sciences, Metabolism and Neuroscience, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy. Electronic address: Stefano.meletti@unimore.it.
authors: Stefano
authors: S
authors: Meletti
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D003700:Delta Rhythm / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004829:Epilepsy, Generalized / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012303:Ring Chromosomes; D013826:Theta Rhythm / Q000502:physiology*
keywords: EEG; Electrical source imaging; Epilepsy; Mu rhythm; Sensory-motor network