title: Phospholipase C-β in immune cells.
abstract: Great progress has recently been made in structural and functional research of phospholipase C (PLC)-β. We now understand how PLC-β isoforms (β1-β4) are activated by GTP-bound Gαq downstream of G protein-coupled receptors. Numerous studies indicate that PLC-βs participate in the differentiation and activation of immune cells that control both the innate and adaptive immune systems. The PLC-β3 isoform also interplays with tyrosine kinase-based signaling pathways, to inhibit Stat5 activation by recruiting the protein-tyrosine phosphatase SHP-1, with which PLC-β3 and Stat5 form a multi-molecular signaling platform, named SPS complex. The SPS complex has important regulatory roles in tumorigenesis and immune cell activation.
authors: Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Laboratory of Allergic Disease, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama 230-0045, Japan. Electronic address: toshi@liai.org.
authors: Toshiaki
authors: T
authors: Kawakami
authors: Wenbin
authors: W
authors: Xiao
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000201:enzymology / Q000276:immunology; D007527:Isoenzymes / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D022423:Myeloid Cells / Q000201:enzymology* / Q000276:immunology; D054799:Phospholipase C beta / Q000235:genetics / Q000276:immunology*
chemical_list: D007527:Isoenzymes; D054799:Phospholipase C beta
keywords: B cell receptor; BCR; C-terminal; CT; DAG; G-protein-coupled receptor; GAP; GPCR; GTPase-activating protein; HSC; IL; IP(3); ITAM; NP; PG; PKC; PLC; SH2; Src homology 2; T cell receptor; T cell-independent; TCR; TI; TNFα; diacylglycerol; dko; double knockout; hematopoietic stem cell; hydroxylnitrophenyl; immunoreceptor tyrosine-based activation motif; inositol 1,4,5-trisphosphate; interleukin; phospholipase C; prostaglandin; protein kinase C; tumor necrosis factor α
references: Cancer Cell. 2009 Aug 4;16(2):161-71
references: 19647226
references: J Lipid Res. 2009 Apr;50 Suppl:S243-8
references: 19033212
references: Nat Immunol. 2008 Nov;9(11):1215-23
references: 18936782
references: Annu Rev Immunol. 1999;17:931-72
references: 10358778
references: Annu Rev Pharmacol Toxicol. 2006;46:355-79
references: 16402909
references: Immunity. 2002 Mar;16(3):441-51
references: 11911828
references: Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7971-5
references: 9223297
references: J Immunol. 2013 Jun 15;190(12):6589-95
references: 23690479
references: Immunity. 2006 Aug;25(2):213-24
references: 16919488
references: Science. 2000 Feb 11;287(5455):1046-9
references: 10669417
references: Int Arch Allergy Appl Immunol. 1986;80(3):285-90
references: 3087885
references: Blood. 2010 Dec 23;116(26):6003-13
references: 20858858
references: Nature. 1992 Jan 2;355(6355):78-80
references: 1370575
references: Adv Biol Regul. 2012 Jan;52(1):7-15
references: 21982978
references: Immunol Lett. 2007 Nov 15;113(2):59-69
references: 17919738
references: Circulation. 2009 Sep 1;120(9):774-84
references: 19687358
references: Science. 2010 Nov 12;330(6006):974-80
references: 20966218
references: Immunity. 2006 Jul;25(1):67-78
references: 16860758
references: BMB Rep. 2008 Jun 30;41(6):415-34
references: 18593525
references: J Allergy Clin Immunol. 2000 Apr;105(4):782-7
references: 10756230
references: Br J Haematol. 2000 Dec;111(4):1209-14
references: 11167763
references: Am J Pathol. 2009 Dec;175(6):2439-53
references: 19850892
references: Annu Rev Immunol. 2004;22:891-928
references: 15032599
references: J Biomed Sci. 2011 Jun 13;18:38
references: 21663700
references: Cell Signal. 2013 Jan;25(1):255-63
references: 23006664
references: Hum Mol Genet. 2010 May 15;19(10):2079-85
references: 20172861
references: Annu Rev Immunol. 2009;27:591-619
references: 19132916
references: Nat Immunol. 2004 Sep;5(9):943-52
references: 15300245
references: Nat Rev Immunol. 2004 Apr;4(4):301-8
references: 15057788
references: Science. 1998 Jul 17;281(5375):413-6
references: 9665884
references: Nat Struct Mol Biol. 2013 Mar;20(3):355-62
references: 23377541
references: Subcell Biochem. 2012;58:61-94
references: 22403074
references: Annu Rev Physiol. 2013;75:127-54
references: 23140367
references: J Immunol. 2003 Jul 1;171(1):360-7
references: 12817019
references: Nat Struct Mol Biol. 2011 Aug 07;18(9):999-1005
references: 21822282
references: Annu Rev Biochem. 2001;70:281-312
references: 11395409
references: Trends Biochem Sci. 2011 Feb;36(2):88-96
references: 20870410
references: J Immunol. 2011 Aug 1;187(3):1440-7
references: 21705626
references: Nat Rev Immunol. 2009 Apr;9(4):259-70
references: 19282852
references: J Immunol. 2005 Nov 15;175(10):6885-92
references: 16272347
references: Immunity. 2010 May 28;32(5):593-604
references: 20510870
references: J Biol Chem. 1994 Feb 25;269(8):5918-25
references: 8119935
references: Annu Rev Immunol. 2005;23:127-59
references: 15771568
references: Cell. 2011 Apr 29;145(3):341-55
references: 21529710
references: Immunol Rev. 1992 Feb;125:37-48
references: 1532373
references: Nature. 1996 Aug 15;382(6592):635-8
references: 8757135
references: J Biol Chem. 2011 Apr 8;286(14):12407-16
references: 21266572
references: J Clin Invest. 2008 Jan;118(1):195-204
references: 18079968
references: PLoS One. 2010 Aug 03;5(8):e11944
references: 20689814
references: PLoS Negl Trop Dis. 2008;2(12):e305
references: 19104650
references: Nat Med. 2012 May 04;18(5):693-704
references: 22561833
references: Cell Signal. 2008 Apr;20(4):625-36
references: 18207701
references: Mol Cell. 2006 Feb 17;21(4):495-507
references: 16483931
references: Blood. 2005 Sep 1;106(5):1703-10
references: 15899916
references: PLoS One. 2011;6(9):e24995
references: 21949826
references: Nat Rev Immunol. 2010 Jun;10(6):440-52
references: 20498670
references: Nat Immunol. 2011 Oct 30;12(12):1212-20
references: 22037603
references: EMBO Rep. 2006 Oct;7(10):1023-9
references: 16888650
references: EMBO J. 1998 Apr 1;17(7):1961-72
references: 9524119
references: Blood. 2003 Sep 15;102(6):1959-65
references: 12750173
references: Hum Immunol. 1998 Jan;59(1):25-8
references: 9544236
references: Cell Mol Immunol. 2010 Nov;7(6):428-39
references: 20871625
references: J Biol Chem. 1993 Nov 5;268(31):23318-24
references: 7693687
references: Immunity. 2011 Jun 24;34(6):893-904
references: 21683628
references: Cell. 1996 Dec 13;87(6):1037-47
references: 8978608
references: Dev Comp Immunol. 2010 May;34(5):481-4
references: 20043942
references: J Clin Invest. 1991 Feb;87(2):446-53
references: 1991831
references: J Immunol. 2007 Aug 15;179(4):2223-7
references: 17675482
references: Science. 2006 Jul 28;313(5786):526-30
references: 16873664