title: Characterization of changes in total body composition for patients with head and neck cancer undergoing chemoradiotherapy using dual-energy x-ray absorptiometry.
abstract: BACKGROUND
  Patients with head and neck cancer experience significant weight loss secondary to concurrent chemoradiotherapy (CCRT). Using dual-energy X-ray absorptiometry (DEXA) scans, we characterize total body composition changes during and after CCRT in order to develop novel clinical care models that will improve the patient's quality of life (QOL).
  
  
  METHODS
  Sixty DEXA scans were obtained from 12 patients undergoing CCRT for locally advanced squamous cell head and neck cancer. DEXAs were performed at baseline, during treatment, completion of CCRT, and then 1 and 2 months posttreatment.
  
  
  RESULTS
  Mean weight loss by treatment end was 9.5 kg (10.2%; p = .0002). On average, lean body mass (LBM) decreased 10.2% (p = .001), and fat body mass (FBM) decreased 11.1% (p = .001) during CCRT. LBM began to normalize after completion of treatment, whereas FBM continued to decline.
  
  
  CONCLUSIONS
  Substantial loss of muscle and FBM occurs in patients undergoing CCRT for head and neck cancer. To prevent long-term disability and QOL decline after curative CCRT, clinical care interventions incorporating aggressive nutrition/exercise counseling are needed.
authors: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
authors: William
authors: W
authors: Jackson
authors: Neil
authors: N
authors: Alexander
authors: Matthew
authors: M
authors: Schipper
authors: Lorraine
authors: L
authors: Fig
authors: Felix
authors: F
authors: Feng
authors: Shruti
authors: S
authors: Jolly
mesh_terms: D015502:Absorptiometry, Photon; D001823:Body Composition; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005081:Exercise Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D000077195:Squamous Cell Carcinoma of Head and Neck; D015431:Weight Loss
chemical_list: D003404:Creatinine
keywords: chemoradiotherapy; dual-energy x-ray absorptiometry (DEXA); head and neck cancer; lean body mass; total body composition