title: At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence.
abstract: It is well accepted that non-coding RNAs play a critical role in regulating gene expression. Recent paradigm-setting studies are now revealing that non-coding RNAs, other than microRNAs, also play intriguing roles in the maintenance of chromatin structure, in the DNA damage response, and in adult human stem cell aging. In this review, we will discuss the complex inter-dependent relationships among non-coding RNA transcription, maintenance of genomic stability, chromatin structure, and adult stem cell senescence. DNA damage-induced non-coding RNAs transcribed in the vicinity of the DNA break regulate recruitment of the DNA damage machinery and DNA repair efficiency. We will discuss the correlation between non-coding RNAs and DNA damage repair efficiency and the potential role of changing chromatin structures around double-strand break sites. On the other hand, induction of non-coding RNA transcription from the repetitive Alu elements occurs during human stem cell aging and hinders efficient DNA repair causing entry into senescence. We will discuss how this fine balance between transcription and genomic instability may be regulated by the dramatic changes to chromatin structure that accompany cellular senescence.
authors: Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center Houston, TX, USA.
authors: Ryosuke
authors: R
authors: Ohsawa
authors: Ja-Hwan
authors: JH
authors: Seol
authors: Jessica K
authors: JK
authors: Tyler
keywords: aging; chromatin; genomic instability; non-coding RNA; senescence
references: Cell Mol Life Sci. 2012 May;69(9):1447-73
references: 22083606
references: Cell. 2007 Nov 30;131(5):901-14
references: 18001825
references: Plant J. 2006 Dec;48(6):947-61
references: 17227549
references: J Cell Sci. 2012 Jan 1;125(Pt 1):7-17
references: 22294612
references: Adv Exp Med Biol. 2012;724:317-31
references: 22411253
references: Mol Gen Genet. 1989 Sep;218(3):465-74
references: 2555668
references: Exp Gerontol. 1996 Jan-Apr;31(1-2):281-93
references: 8706797
references: Mol Cell. 2004 May 21;14(4):501-13
references: 15149599
references: Curr Biol. 2003 Sep 2;13(17):1549-56
references: 12956959
references: Nat Struct Mol Biol. 2012 Feb 12;19(3):276-82
references: 22343725
references: Mol Cell. 2012 Dec 14;48(5):723-33
references: 23122415
references: Mol Cell. 2011 Jan 7;41(1):46-55
references: 21211722
references: Mutat Res. 1987 Mar;177(1):53-60
references: 3029582
references: Curr Biol. 2002 Aug 6;12(15):1279-86
references: 12176355
references: Genes Dev. 2009 May 15;23(10):1207-20
references: 19451221
references: Epigenetics. 2012 Jul;7(7):680-8
references: 22647267
references: Cell. 2010 Jun 11;141(6):970-81
references: 20550933
references: Oncogene. 2000 Jun 15;19(26):3021-31
references: 10871854
references: Nature. 2011 Nov 02;479(7372):232-6
references: 22048312
references: Cell. 2012 Mar 30;149(1):101-12
references: 22445173
references: Mol Cell. 2012 Apr 27;46(2):212-25
references: 22424773
references: Curr Opin Genet Dev. 2012 Apr;22(2):156-63
references: 22243696
references: Nature. 2007 Jun 7;447(7145):730-4
references: 17554310
references: FEBS Lett. 2012 Nov 2;586(21):3920-5
references: 23031826
references: Mol Cell Biol. 2007 Mar;27(6):2343-58
references: 17242207
references: Mol Cell. 2010 Oct 22;40(2):228-37
references: 20965418
references: Mol Cell. 2010 Nov 24;40(4):632-44
references: 21055984
references: Cell. 2006 Dec 29;127(7):1361-73
references: 17190600
references: J Biol Chem. 2009 Oct 30;284(44):30424-32
references: 19740755
references: Exp Gerontol. 1998 Aug;33(5):393-419
references: 9762520
references: Nucleic Acids Res. 1994 Mar 25;22(6):1087-95
references: 7512262
references: Nat Rev Genet. 2013 Jan;14(1):62-75
references: 23247436
references: Trends Biochem Sci. 2011 Sep;36(9):478-84
references: 21741842
references: J Cell Biol. 2010 Oct 4;191(1):31-43
references: 20876283
references: Nature. 2009 May 14;459(7244):274-7
references: 19444217
references: Science. 2007 Jul 13;317(5835):245-8
references: 17626885
references: Science. 2002 May 3;296(5569):922-7
references: 11934988
references: Cell. 2006 Nov 3;127(3):481-93
references: 17081972
references: Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40
references: 17667954
references: Dev Cell. 2005 Jan;8(1):19-30
references: 15621527
references: Exp Cell Res. 1965 Mar;37:614-36
references: 14315085
references: Genes Chromosomes Cancer. 2001 Jan;30(1):64-71
references: 11107177
references: Mol Cell Biol. 2009 Nov;29(21):5645-56
references: 19704005
references: Cell. 2005 Dec 29;123(7):1213-26
references: 16377563
references: Nat Struct Mol Biol. 2010 Oct;17(10):1218-25
references: 20890289
references: Nat Cell Biol. 2006 Aug;8(8):870-6
references: 16862143
references: Mech Ageing Dev. 2007 Jan;128(1):36-44
references: 17116315
references: Nature. 2003 Feb 27;421(6926):961-6
references: 12607005
references: Nature. 2009 Jun 11;459(7248):802-7
references: 19516333
references: Nat Cell Biol. 2012 Feb 19;14(3):318-28
references: 22344029
references: Eukaryot Cell. 2011 Sep;10(9):1148-55
references: 21724934
references: FEBS Lett. 1998 Oct 30;438(1-2):41-8
references: 9821956
references: Adv Drug Deliv Rev. 2013 Mar;65(3):368-75
references: 22820533
references: Nat Struct Mol Biol. 2009 Sep;16(9):923-9
references: 19680243
references: Cell. 2007 Nov 30;131(5):887-900
references: 18001824
references: EMBO J. 2012 May 2;31(9):2169-81
references: 22373577
references: Cell. 2008 Jul 25;134(2):231-43
references: 18662539
references: Cell Mol Life Sci. 2012 Sep;69(17):2895-906
references: 22430204
references: J Mol Cell Biol. 2011 Jun;3(3):151-8
references: 21183529
references: Cell Cycle. 2011 Sep 1;10(17):3016-30
references: 21862875
references: Biochem Biophys Res Commun. 1994 Sep 15;203(2):845-51
references: 8093066
references: Cell Cycle. 2010 Apr 15;9(8):1568-76
references: 20421735
references: Mol Cell. 2006 Jan 20;21(2):187-200
references: 16427009
references: Nature. 2004 Nov 18;432(7015):406-11
references: 15525939
references: Mutat Res. 1990 Mar;229(1):69-77
references: 2156159
references: Ageing Res Rev. 2013 Jan;12(1):429-35
references: 22504407
references: Nat Cell Biol. 2006 Jan;8(1):91-9
references: 16341205
references: Mol Cell. 2010 Oct 22;40(2):179-204
references: 20965415
references: Cell. 1996 Feb 23;84(4):633-42
references: 8598049
references: Nucleic Acids Res. 2011 Oct;39(18):7931-45
references: 21727091
references: Mol Cell. 2004 Dec 22;16(6):991-1002
references: 15610741
references: Nature. 2012 Aug 9;488(7410):231-5
references: 22722852
references: J Cell Biol. 2006 Nov 6;175(3):389-400
references: 17074886
references: Nucleic Acids Res. 2012 Nov 1;40(20):10287-301
references: 22941645
references: J Cell Sci. 2005 May 1;118(Pt 9):2043-55
references: 15840649
references: Nat Cell Biol. 2004 Feb;6(2):168-70
references: 14755273
references: Mol Cell. 2010 Sep 10;39(5):724-35
references: 20832724
references: PLoS Biol. 2010 Oct 05;8(10):
references: 20957187
references: Aging (Albany NY). 2012 Nov;4(11):823-42
references: 23235539
references: Exp Gerontol. 1997 Jul-Oct;32(4-5):383-94
references: 9315443
references: Science. 2005 Dec 23;310(5756):1954-7
references: 16373574
references: Nature. 2003 Nov 13;426(6963):194-8
references: 14608368
references: Aging Cell. 2011 Apr;10(2):292-304
references: 21176091