title: Quality of life of patients with ADPKD-Toranomon PKD QOL study: cross-sectional study.
abstract: BACKGROUND
  The quality of life (QOL) of patients with autosomal dominant polycystic kidney disease (ADPKD) has not been investigated well. This study was performed to clarify the QOL of patients with ADPKD and to identify factors that affected their QOL.
  
  
  METHODS
  The present cross-sectional study is part of a prospective observational study on the QOL of ADPKD patients. Patients with ADPKD who were referred to Toranomon Hospital between March 2010 and November 2012 were enrolled. The short form-36 (SF-36) questionnaire and our original 12-item questionnaire were used to evaluate QOL. We analyzed the results of the questionnaire survey and then investigated correlations between QOL and clinical features.
  
  
  RESULTS
  A total of 219 patients (93 men and 126 women) were enrolled and their mean age was 55.1 ± 10.8 years. There were 108 patients on dialysis. The SF-36 scores (PCS, MCS, and RCS) of all patients were significantly lower than the mean scores for the Japanese population. Stepwise multiple regression analysis demonstrated that Hb, serum Alb, ascites, and cerebrovascular disease all had a significant influence on the PCS, while mental disease had a significant influence on the MCS and serum Alb significantly influenced the RCS. The total liver and kidney volume (TLKV) and the dialysis status were not significantly associated with any of the SF-36 scores by multiple regression analysis, but TLKV was closely correlated with abdominal distention and distention had an important influence on QOL. Pain, sleep disturbance, heartburn, fever, gross hematuria, and anorexia also affected QOL, but these variables were not correlated with TLKV.
  
  
  CONCLUSIONS
  Several factors influence QOL, so improving symptoms unrelated to TLKV as well as reducing abdominal distention can improve the QOL of ADPKD patients.
authors: Department of Nephrology, Toranomon Hospital, Tokyo, Japan. suwabe@toranomon.gr.jp.
authors: Tatsuya
authors: T
authors: Suwabe
authors: Yoshifumi
authors: Y
authors: Ubara
authors: Koki
authors: K
authors: Mise
authors: Masahiro
authors: M
authors: Kawada
authors: Satoshi
authors: S
authors: Hamanoue
authors: Keiichi
authors: K
authors: Sumida
authors: Noriko
authors: N
authors: Hayami
authors: Junichi
authors: J
authors: Hoshino
authors: Rikako
authors: R
authors: Hiramatsu
authors: Masayuki
authors: M
authors: Yamanouchi
authors: Eiko
authors: E
authors: Hasegawa
authors: Naoki
authors: N
authors: Sawa
authors: Kenmei
authors: K
authors: Takaichi
mesh_terms: D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000523:psychology*; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology / Q000523:psychology* / Q000534:rehabilitation; D015995:Prevalence; D011788:Quality of Life / Q000523:psychology*; D006435:Renal Dialysis / Q000523:psychology* / Q000706:statistics & numerical data*; D012307:Risk Factors; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
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