title: MALAT-1 interacts with hnRNP C in cell cycle regulation.
abstract: As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.
authors: Institute of Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100871, China.
authors: Feng
authors: F
authors: Yang
authors: Fan
authors: F
authors: Yi
authors: Xiaorui
authors: X
authors: Han
authors: Quan
authors: Q
authors: Du
authors: Zicai
authors: Z
authors: Liang
mesh_terms: D001692:Biological Transport; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D015536:Down-Regulation; D005434:Flow Cytometry; D016195:G2 Phase; D020868:Gene Silencing; D006367:HeLa Cells; D056945:Hep G2 Cells; D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C / Q000378:metabolism*; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
chemical_list: D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C; C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding
keywords: Cell cycle; Long non-coding RNA; MALAT-1; hnRNP C