title: Dried blood spots in bioanalysis of antimalarials: relevance and challenges in quantitative assessment of antimalarial drugs.
abstract: Malaria is the leading parasitic disease in emerging countries. Therapeutic drug monitoring of antimalarial drugs is becoming increasingly important due to their spreading resistance. Measuring systemic antimalarial drug concentrations is also vital for safety and PK evaluations during clinical development. The dried blood spot (DBS) technique is a convenient alternative sample-collection method to venipuncture, especially in resource -limited areas where the clinical studies of antimalarials are usually carried out. Various bioanalytical methods for antimalarial drug estimation utilizing DBS sampling have been reported. This review discusses the applicability and relevance of DBS in quantitative assessment of antimalarial drugs, the advantages and drawbacks of DBS, and the difficulties encountered during its implementation.
authors: Academy of Scientific & Industrial Research, New Delhi, India.
authors: Isha
authors: I
authors: Taneja
authors: Madhuri
authors: M
authors: Erukala
authors: Kanumuri Siva Rama
authors: KS
authors: Raju
authors: Sheelendra Pratap
authors: SP
authors: Singh
authors: Wahajuddin
mesh_terms: D000962:Antimalarials / Q000097:blood* / Q000145:classification / Q000627:therapeutic use; D001800:Blood Specimen Collection / Q000379:methods; D002853:Chromatography, Liquid; D059788:Dried Blood Spot Testing / Q000592:standards* / Q000706:statistics & numerical data; D016903:Drug Monitoring; D004355:Drug Stability; D006400:Hematocrit; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D012680:Sensitivity and Specificity; D052617:Solid Phase Microextraction; D012997:Solvents; D053719:Tandem Mass Spectrometry
chemical_list: D000962:Antimalarials; D012997:Solvents