title: The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.
abstract: OBJECTIVE
  Prognosis after curative resection of colorectal liver metastases is hard to determine based on clinical parameters; biomarkers are therefore needed. The purpose of this study was to determine the value of desmocollins (DSC) as potential biomarkers. Desmocollins are responsible for cell-cell adhesion in epithelial tissue; their loss may lead to reduced cellular adhesion and facilitate cellular migration, enabling tumor cells to form distant metastases. We analyzed DSC expression in colorectal liver metastases with respect to the risk of recurrence following liver resection.
  
  
  METHODS
  Tissue microarrays from 257 consecutive patients who underwent R0-resection of colorectal liver metastases were constructed.
  
  
  RESULTS
  Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases. There was no correlation between site or stage of the primary tumor, presence of extrahepatic tumor, grading, size or number of metastases, and desmocollin expression. Primary tumor stage I or II (p = 0.005) and no or few lymph node metastases (p < 0.001) were associated with a significantly better disease-free survival on univariate analysis. These parameters reached only marginal significance on multivariate analysis (p = 0.059 and p = 0.052, respectively), as did desmocollin 3 expression (p = 0.050). In the subgroup of patients with stages III-IV primary tumors, however, multivariate analysis showed a significant correlation between DSC 3 expression and disease-free survival after liver resection (p = 0.009).
  
  
  CONCLUSIONS
  Reduced expression of DSC3 correlated with an increased risk of developing tumor recurrence after resection of liver metastases. These findings may be helpful in selecting high-risk patients who might benefit from multimodal therapy.
authors: Department of General, Visceral, and Vascular Surgery, Jena University Hospital, Erlanger Allee 101, 07740, Jena, Germany, silke.schuele@med.uni-jena.de.
authors: Silke
authors: S
authors: Schüle
authors: Claudia
authors: C
authors: Neuhäuser
authors: Falk
authors: F
authors: Rauchfuß
authors: Thomas
authors: T
authors: Knösel
authors: Utz
authors: U
authors: Settmacher
authors: Annelore
authors: A
authors: Altendorf-Hofmann
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D051187:Desmocollins / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary* / Q000601:surgery*; D008297:Male; D009367:Neoplasm Staging; D019990:Perioperative Care; D011379:Prognosis
chemical_list: C081560:DSC1 protein, human; C081561:DSC2 protein, human; C490356:DSC3 protein, human; D051187:Desmocollins
references: HPB (Oxford). 2010 May;12(4):227-38
references: 20590892
references: Br J Surg. 2012 Apr;99(4):477-86
references: 22261895
references: Ann Surg Oncol. 2010 Feb;17(2):492-501
references: 19856028
references: Hum Pathol. 2010 Oct;41(10):1456-65
references: 20621329
references: Br J Surg. 2010 Jul;97(7):1110-8
references: 20632280
references: Eur J Surg Oncol. 2010 Jun;36(6):568-74
references: 20413243
references: Cell Oncol. 2006;28(4):167-75
references: 16988472
references: Cancer. 1996 Apr 1;77(7):1254-62
references: 8608500
references: Ann Surg Oncol. 2012 Jan;19(1):139-44
references: 21751045
references: Br J Cancer. 2011 Mar 15;104(6):1013-9
references: 21364582
references: Int J Colorectal Dis. 2011 Aug;26(8):967-81
references: 21584664
references: Br J Cancer. 2012 Feb 14;106(4):756-62
references: 22333708
references: Lancet. 2008 Mar 22;371(9617):1007-16
references: 18358928
references: Int J Colorectal Dis. 2012 Nov;27(11):1391-9
references: 22438068
references: Neoplasia. 2005 Aug;7(8):741-7
references: 16207476
references: Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21
references: 10493478
references: Hum Pathol. 2011 Mar;42(3):409-18
references: 21193224
references: J Clin Pathol. 2011 Nov;64(11):990-4
references: 21725043
references: Ann Surg. 2007 Aug;246(2):183-91
references: 17667495
references: J Am Coll Surg. 1999 Sep;189(3):291-9
references: 10472930
references: J Pathol. 2010 Jul;221(3):275-84
references: 20527021