title: Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma.
abstract: Human hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Currently, surgical resection is the only effective treatment for HCC if the tumor is resectable. Small molecule, biologics and siRNA anti-cancer drugs have been explored for the treatment of HCC. Selective targeting to tumor tissue rather than normal liver in HCC patients is still a challenge. Galactosamine-mediated targeting delivery of anti-cancer drugs in the liver has been tested because its receptor, asialoglycoprotein receptor 1 (ASGPR1), is expressed in the liver and not in other human tissues. We examined ASGPR1 expression levels by immunohistochemistry in HCC with different grades. Guidance for a targeting delivery strategy for anti-cancer drugs to HCC is suggested in this report.
authors: Department of In Vivo Pharmacology - Oncology, Merck Research Laboratories, Merck & Co., Inc., West Point, PA (BS).
authors: Bin
authors: B
authors: Shi
authors: Marc
authors: M
authors: Abrams
authors: Laura
authors: L
authors: Sepp-Lorenzino
mesh_terms: D037263:Asialoglycoprotein Receptor / Q000032:analysis* / Q000096:biosynthesis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C546927:ASGR1 protein, human; D037263:Asialoglycoprotein Receptor
keywords: ASGPR; galactosamine; galactose; human hepatocellular carcinoma (HCC); immunohistochemistry; targeting delivery
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