title: Cleaning and asthma characteristics in women.
abstract: BACKGROUND
  We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects.
  
  
  METHODS
  Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
  
  
  RESULTS
  Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)).
  
  
  CONCLUSIONS
  Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.
authors: Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807, Villejuif, France; Univ Paris-Sud, UMRS 1018, F-94807, Villejuif, France.
authors: Orianne
authors: O
authors: Dumas
authors: Valérie
authors: V
authors: Siroux
authors: Frédéric
authors: F
authors: Luu
authors: Rachel
authors: R
authors: Nadif
authors: Jan-Paul
authors: JP
authors: Zock
authors: Francine
authors: F
authors: Kauffmann
authors: Nicole
authors: N
authors: Le Moual
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000503:physiopathology*; D016022:Case-Control Studies; D003902:Detergents; D004202:Disinfectants; D005260:Female; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D016017:Odds Ratio; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D003902:Detergents; D004202:Disinfectants
keywords: asthma characteristics; cleaning product; occupational asthma; occupational exposure; work-related asthma