title: XRCC3 and RAD51 expression are associated with clinical factors in breast cancer.
abstract: OBJECTIVE
  XRCC3 and RAD51 are two important members in homologous recombination repair pathway. This study was performed to detect the expressions of these two molecules in breast cancer and explore their correlations with clinicopathological factors.
  
  
  RESULTS
  Immunohistochemistry was used to detect protein expressions of XRCC3 and RAD51 in 248 cases of breast cancer tissue and 78 cases of adjacent non-cancerous tissue. Data showed that expressions for both XRCC3 and RAD51 were significantly increased in breast cancer. High XRCC3 expression was associated with large tumor size and positive PR and HER2 status, while high RAD51 expression was associated with axillary lymph node metastasis and positive PR and HER2 status. The result of multivariate analysis demonstrated that HER2, PR and RAD51 were significantly association with XRCC3. And besides XRCC3, axillary lymph node metastasis and PR were significantly correlated with RAD51.
  
  
  CONCLUSIONS
  XRCC3 and RAD51 were significantly associated with clinicopathological factors and they might play important roles in the development and progress of breast cancer.
authors: The Second Department of Oncology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, P.R. China ; Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
authors: Jia
authors: J
authors: Hu
authors: Ning
authors: N
authors: Wang
authors: Ya-Jie
authors: YJ
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000556:secondary; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D051135:Rad51 Recombinase / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D011980:Receptors, Progesterone; C110901:X-ray repair cross complementing protein 3; C495153:RAD51 protein, human; D051135:Rad51 Recombinase
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