title: Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens.
abstract: Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Xia
authors: X
authors: Liu
authors: Xing-Wei
authors: XW
authors: Yang
authors: Chao-Qun
authors: CQ
authors: Chen
authors: Chun-Yan
authors: CY
authors: Wu
authors: Jing-Jing
authors: JJ
authors: Zhang
authors: Jun-Zeng
authors: JZ
authors: Ma
authors: Huan
authors: H
authors: Wang
authors: Li-Xin
authors: LX
authors: Yang
authors: Gang
authors: G
authors: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D010696:Phloroglucinol