title: Structural perspective on the formation of ribonucleoprotein complex in negative-sense single-stranded RNA viruses.
abstract: Negative-sense single-stranded RNA viruses (NSRVs) possess a ribonucleoprotein (RNP) complex composed of viral polymerase and genomic RNA surrounded by viral nucleoprotein. The RNP facilitates virus replication, transcription, and assembly. To date, a large body of structural work, through crystallography and electron microscopy (EM) analysis, has been performed to aid understanding the molecular mechanism of RNP formation in NSRVs, and provides great potential for the discovery of antiviral agents targeting viral RNP formation.
authors: State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, China; Laboratory of Structural Biology and Ministry of Education (MOE) Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.
authors: Honggang
authors: H
authors: Zhou
authors: Yuna
authors: Y
authors: Sun
authors: Yu
authors: Y
authors: Guo
authors: Zhiyong
authors: Z
authors: Lou
mesh_terms: D000818:Animals; D006801:Humans; D012328:RNA Viruses / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology
chemical_list: D012367:RNA, Viral; D012261:Ribonucleoproteins; D014764:Viral Proteins
keywords: antiviral drugs; formation; negative-sense single-stranded RNA virus; ribonucleoprotein complex; structure