title: Hypothermic versus normothermic cardiopulmonary bypass in patients with valvular heart disease.
abstract: OBJECTIVE
  The aim of this study was to test the hypothesis that normothermic cardiopulmonary bypass (CPB) is as effective as hypothermic CPB in terms of cardiac protection (cTnI level) and outcome in patients with valvular heart disease.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  A tertiary cardiothoracic referral center.
  
  
  METHODS
  140 patients who had valvular heart disease, with/without coronary artery disease, surgically treated under CPB.
  
  
  METHODS
  The patients were allocated randomly to undergo either hypothermic (temperature [T], 31 °C-32 °C) or normothermic CPB (T>36 °C).
  
  
  RESULTS
  The primary endpoint was the dynamics of troponin I. The secondary endpoints were ventilation time, the need for inotropic support, intensive care unit (ICU) and hospital stay durations, complications, and mortality. There were no significant intergroup differences in dynamics of troponin I. Ventilation time was significantly lower in the hypothermic group (6 (5-9) and 8 (5-12); p = 0.01).
  
  
  CONCLUSIONS
  Normothermic CPB in patients with valvular heart disease was as effective as hypothermic perfusion in terms of myocardial protection after the surgery assessed by cTnI release. The short ventilation duration in patients who underwent hypothermic CPB needs to be confirmed in a future investigation.
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Vladimir V
authors: VV
authors: Lomivorotov
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Vladimir A
authors: VA
authors: Shmirev
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia. Electronic address: sergefremov@mail.ru.
authors: Sergey M
authors: SM
authors: Efremov
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Dmitry N
authors: DN
authors: Ponomarev
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Gleb B
authors: GB
authors: Moroz
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Denis G
authors: DG
authors: Shahin
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Igor A
authors: IA
authors: Kornilov
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Anna N
authors: AN
authors: Shilova
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Vladimir N
authors: VN
authors: Lomivorotov
authors: Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Alexander M
authors: AM
authors: Karaskov
mesh_terms: D000328:Adult; D000368:Aged; D001831:Body Temperature; D006348:Cardiac Surgical Procedures / Q000379:methods* / Q000401:mortality; D002315:Cardiopulmonary Bypass / Q000379:methods* / Q000401:mortality; D002316:Cardiotonic Agents / Q000627:therapeutic use; D003422:Critical Care; D023381:Endpoint Determination; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D012121:Respiration, Artificial; D019210:Troponin I / Q000097:blood
chemical_list: D002316:Cardiotonic Agents; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: cardiac protection; cardiac surgery; cardiopulmonary bypass; heart valve disease; hypothermia; normothermia