title: Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis.
abstract: Previous studies have shown that apolipoprotein A5 (APOA5) gene variants are genetic determinants of the concentration of triglycerides, which are a known risk factor for coronary heart disease (CHD). Using the standardized coronary angiography method, 290 CHD patients and 198 non‑CHD controls were recruited from Ningbo Lihuili Hospital. In addition, 331 unrelated healthy volunteers were recruited as healthy controls from Ningbo Ximen Community residents. Three variants of the APOA5 gene, S19W, ‑1131T>C and 553G>T, were analyzed for their association with CHD. Under a dominant inheritance model, ‑1131CT>C was shown to be a CHD risk factor (P=0.030; OR, 1.422; 95% CI, 1.036‑1.952). The single nucleotide polymorphism, 553G>T, was found to correlate with the severity of CHD in males (P=0.032). Meta‑analysis showed that ‑1131T>C was significantly associated with CHD (P<0.0001). By contrast, negative correlations with CHD were observed for S19W and 553G>T. In the present case‑control study, APOA5 gene variants were not found to correlate with the risk of CHD in the populations studied; however, ‑1131CT>C was shown to be a CHD risk factor under a dominant inheritance model. Meta‑analysis showed a significant contribution of ‑1131T>C to the risk of CHD, implying an ethnic difference in APOA5 gene variants.
authors: Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, P.R. China.
authors: Jianqing
authors: J
authors: Zhou
authors: Limin
authors: L
authors: Xu
authors: Rong Stephanie
authors: RS
authors: Huang
authors: Yi
authors: Y
authors: Huang
authors: Yanping
authors: Y
authors: Le
authors: Danjie
authors: D
authors: Jiang
authors: Xi
authors: X
authors: Yang
authors: Weifeng
authors: W
authors: Xu
authors: Xiaoyan
authors: X
authors: Huang
authors: Changzheng
authors: C
authors: Dong
authors: Meng
authors: M
authors: Ye
authors: Jiangfang
authors: J
authors: Lian
authors: Shiwei
authors: S
authors: Duan
mesh_terms: D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A
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