title: Draft genome sequences of two super-extensively  drug-resistant isolates of Mycobacterium tuberculosis  from China.
abstract: The prevalence of drug-resistance in Mycobacterium tuberculosis is already having a negative impact on the control of tuberculosis. We report the draft genome sequences of two super-extensively drug-resistant M. tuberculosis isolates from China, FJ05194 (lineage 2) and GuangZ0019 (lineage 4), and compare them with the H37Rv reference strain to identify possible sources of genetic variation associated with their extensive drug resistance. Our results suggest that their extensive drug resistance probably results from the stepwise accumulation of resistances to individual drugs.
authors: Nan
authors: N
authors: Lin
authors: Zhangyi
authors: Z
authors: Liu
authors: Jie
authors: J
authors: Zhou
authors: Shihua
authors: S
authors: Wang
authors: Joy
authors: J
authors: Fleming
mesh_terms: D002681:China; D004269:DNA, Bacterial / Q000235:genetics; D054908:Extensively Drug-Resistant Tuberculosis / Q000382:microbiology*; D014644:Genetic Variation; D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004269:DNA, Bacterial