title: HIV antiretroviral resistance mutations among antiretroviral treatment-naive and -experienced patients in South Korea.
abstract: The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.
authors: 1 Department of Internal Medicine, Yonsei University College of Medicine , Seoul, Korea.
authors: Min Hyung
authors: MH
authors: Kim
authors: Je Eun
authors: JE
authors: Song
authors: Jin Young
authors: JY
authors: Ahn
authors: Yong Chan
authors: YC
authors: Kim
authors: Dong Hyun
authors: DH
authors: Oh
authors: Heun
authors: H
authors: Choi
authors: Hea Won
authors: HW
authors: Ann
authors: Jae Kyoung
authors: JK
authors: Kim
authors: Sun Bean
authors: SB
authors: Kim
authors: Su Jin
authors: SJ
authors: Jeong
authors: Nam Su
authors: NS
authors: Ku
authors: Sang Hoon
authors: SH
authors: Han
authors: Young Goo
authors: YG
authors: Song
authors: June Myung
authors: JM
authors: Kim
authors: Jun Yong
authors: JY
authors: Choi
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D056910:Republic of Korea
chemical_list: D019380:Anti-HIV Agents
references: AIDS. 1996 Aug;10(9):975-81
references: 8853730
references: AIDS Res Hum Retroviruses. 2010 Feb;26(2):217-21
references: 20156103
references: Curr HIV Res. 2012 Dec;10(8):647-52
references: 23061604
references: J Korean Med Sci. 2009 Dec;24(6):1031-7
references: 19949656
references: Clin Microbiol Rev. 2002 Apr;15(2):247-77
references: 11932232
references: Tohoku J Exp Med. 2008 Nov;216(3):259-65
references: 18987460