title: Mathematical model of bursting in dissociated purkinje neurons.
abstract: In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (INaP) to be its burst initiator and SK K(+) current (ISK) to be its burst terminator.
authors: Department of Computer Science, University of Warwick, Coventry, West Midlands, United Kingdom. mikeforrest@hotmail.com
authors: Michael D
authors: MD
authors: Forrest
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D020013:Calcium Signaling; D003712:Dendrites / Q000502:physiology; D008959:Models, Neurological; D015221:Potassium Channels / Q000378:metabolism; D011689:Purkinje Cells / Q000502:physiology*; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D015221:Potassium Channels; D015222:Sodium Channels
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