title: Cytomegalovirus infection accelerates the process of chronic rejection in rat liver transplantation.
abstract: OBJECTIVE
  Analysis of the pathogenesis of cytomegalovirus (CMV) infection for rat chronic liver rejection.
  
  
  METHODS
  Based on animal models that we previously developed, we divided control and a CMV infection group to analyze survival, histopathology and rejection activity. The level and mRNA expression of transforming growth factor-β1, platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF) were measured in peripheral blood serum and liver tissue.
  
  
  RESULTS
  Obliterative arteriopathy and fibrosis was significantly greater in the CMV infection versus the control group (P < .05). PDGF mRNA expression in rat liver and in peripheral blood were significantly higher in the CMV infection versus the control group (P < .05). bFGF mRNA expression in the CMV infection group was also significantly higher than among the controls (P < .05).
  
  
  CONCLUSIONS
  CMV infection aggravated foam cell obliterative arteriopathy and liver fibrosis in chronic liver rejection, processes that accelerate the immune response, which may correlate with early high PDGF and bFGF expression.
authors: Department of Hepatobiliary and Pancreatic Surgery and Center of Organ Transplantation, the First Affiliated Hospital, Nanchang University, Nanchang, China. gaolianghui@gmail.com
authors: L H
authors: LH
authors: Gao
authors: L X
authors: LX
authors: Zeng
authors: H M
authors: HM
authors: Chen
authors: R H
authors: RH
authors: Wan
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000821:virology; D004195:Disease Models, Animal; D018450:Disease Progression; D016222:Fibroblast Growth Factor 2 / Q000097:blood / Q000235:genetics; D006084:Graft Rejection / Q000097:blood / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000097:blood; D051381:Rats; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C508962:Tgfb1 protein, rat; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2