title: Weaker feedforward inhibition accounts for less pronounced thalamocortical response transformation in mouse vs. rat barrels.
abstract: Feedforward inhibition is a common motif of thalamocortical circuits. Strong engagement of inhibitory neurons by thalamic inputs enhances response differentials between preferred and nonpreferred stimuli. In rat whisker-barrel cortex, robustly driven inhibitory barrel neurons establish a brief epoch during which synchronous or near-synchronous thalamic firing produces larger responses to preferred stimuli, such as high-velocity deflections of the principal whisker in a preferred direction. Present experiments in mice show that barrel neuron responses to preferred vs. nonpreferred stimuli differ less than in rats. In addition, fast-spike units, thought to be inhibitory barrel neurons, fire less robustly to whisker stimuli in mice than in rats. Analyses of real and simulated data indicate that mouse barrel circuitry integrates thalamic inputs over a broad temporal window, and that, as a consequence, responses of barrel neurons are largely similar to those of thalamic neurons. Results are consistent with weaker feedforward inhibition in mouse barrels. Differences in thalamocortical circuitry between mice and rats may reflect mechanical properties of the whiskers themselves.
authors: Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors: E E
authors: EE
authors: Kwegyir-Afful
authors: H T
authors: HT
authors: Kyriazi
authors: D J
authors: DJ
authors: Simons
mesh_terms: D000818:Animals; D003198:Computer Simulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology*; D010812:Physical Stimulation; D051381:Rats; D013003:Somatosensory Cortex / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology
keywords: cortical circuits; thalamus; whiskers
references: J Neurophysiol. 2000 May;83(5):2791-801
references: 10805677
references: Somatosens Mot Res. 2008 Dec;25(4):209-21
references: 18989828
references: Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):971-6
references: 22219358
references: Cereb Cortex. 2003 Jan;13(1):73-82
references: 12466218
references: Brain Res. 1975 Dec 5;99(2):349-53
references: 1182550
references: J Neurosci. 1993 Apr;13(4):1601-15
references: 8463838
references: J Comp Neurol. 1975 Nov 1;164(1):79-94
references: 809494
references: J Neurosci. 2008 Oct 29;28(44):11153-64
references: 18971458
references: J Neurophysiol. 2004 Jan;91(1):223-9
references: 14507984
references: J Neurophysiol. 1994 Jul;72(1):392-401
references: 7965022
references: Nat Neurosci. 2002 May;5(5):403-4
references: 11967546
references: Nat Neurosci. 2005 Oct;8(10):1364-70
references: 16158064
references: J Comp Neurol. 1974 Dec 15;158(4):437-53
references: 4141363
references: Neuroscience. 1987 Apr;21(1):229-36
references: 3299139
references: Cereb Cortex. 2003 Jan;13(1):33-44
references: 12466213
references: Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1717-27
references: 12626006
references: Nat Neurosci. 2010 Oct;13(10):1240-8
references: 20871602
references: J Neurosci. 2002 Dec 15;22(24):10966-75
references: 12486192
references: J Neurophysiol. 2003 Sep;90(3):1556-70
references: 12724362
references: J Neurophysiol. 2009 Nov;102(5):2955-73
references: 19741102
references: J Neurophysiol. 2011 May;105(5):2421-37
references: 21325677
references: J Neurosci. 2001 Apr 1;21(7):2462-73
references: 11264320
references: Nat Neurosci. 2007 Apr;10(4):462-8
references: 17334362
references: J Neurophysiol. 2008 Jan;99(1):356-66
references: 17989240
references: Curr Opin Neurobiol. 2001 Aug;11(4):488-97
references: 11502397
references: J Neurophysiol. 2003 Apr;89(4):2137-45
references: 12612019
references: J Neurosci. 2006 Jul 26;26(30):7933-41
references: 16870738
references: J Neurophysiol. 2000 Mar;83(3):1158-66
references: 10712446
references: J Neurophysiol. 2005 Jul;94(1):26-32
references: 15985693
references: J Neurophysiol. 1989 Feb;61(2):311-30
references: 2918357
references: PLoS Comput Biol. 2009 Mar;5(3):e1000328
references: 19325875
references: J Comput Neurosci. 1996 Sep;3(3):247-64
references: 8872703
references: Science. 2006 Jun 16;312(5780):1622-7
references: 16778049
references: J Neurosci. 2005 Jun 22;25(25):5926-34
references: 15976081
references: J Neurophysiol. 1978 May;41(3):798-820
references: 660231
references: J Neurophysiol. 2003 Jan;89(1):40-56
references: 12522158
references: J Neurophysiol. 2006 Mar;95(3):1792-9
references: 16338992
references: Neuron. 2011 Jul 14;71(1):180-94
references: 21745647
references: Nature. 1999 Nov 4;402(6757):75-9
references: 10573419
references: Nature. 2003 Nov 27;426(6965):442-6
references: 14647382
references: J Comp Neurol. 1984 Nov 20;230(1):119-32
references: 6512012
references: J Neurosci. 2001 Apr 15;21(8):2699-710
references: 11306623
references: Curr Opin Neurobiol. 2011 Oct;21(5):701-8
references: 21723114
references: Neuron. 2005 Oct 20;48(2):315-27
references: 16242411
references: Brain Behav Evol. 1978;15(5-6):325-71
references: 737526
references: Brain Res. 1983 Oct 3;276(1):178-82
references: 6626997
references: J Neurosci. 2010 Mar 10;30(10):3652-62
references: 20219999
references: J Neurophysiol. 2010 Jun;103(6):3001-16
references: 20375248
references: Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8854-9
references: 9238067
references: Nat Neurosci. 2010 Dec;13(12):1534-41
references: 21102447