title: Penile intraepithelial neoplasia: important lessons from a case series.
abstract: Seven men presenting to our genitourinary (GU) medicine clinic over a period of 22 months had a histopathological diagnosis of penile intraepithelial neoplasia (PIN). Median duration of symptoms was eight months (range 2-216 months). Macroscopic appearances were different in all cases. All histology was reviewed locally and at a tertiary centre. Six of seven had severe dysplasia (PIN III). Interestingly, only one individual was HIV-positive and one, who was immunocompetent, had multifocal disease. These cases highlight the importance of a full anogenital examination and early biopsy in patients presenting with atypical or persistent penile lesions.
authors: Claude Nicol Centre, Royal Sussex County Hospital, Brighton and Sussex University Hospital NHS Trust, Eastern Road, BN2 5BE Brighton, UK. judith.zhou@imperial.nhs.uk
authors: J
authors: J
authors: Zhou
authors: M
authors: M
authors: Howard
authors: D
authors: D
authors: Williams
authors: D
authors: D
authors: Richardson
mesh_terms: D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
keywords: HIV; HPV; PIN; anal intraepithelial neoplasia; biopsy; genital dermatose; human papillomavirus; penile intraepithelial neoplasia; sexually transmitted infections; squamous cell carcinoma