title: Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior.
abstract: OBJECTIVE
  DA-8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA-8031 on male sexual behavior in a rat model.
  
  
  METHODS
  Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA-8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA-8031 at a dose level of 30 mg/kg.
  
  
  RESULTS
  DA-8031 treatment produced a dose-dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P < 0.05). In addition, DA-8031 treatment reduced the mean number of ejaculations in a dose-dependent manner. No changes in post-ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA-8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half-life of 1.79 ± 0.32 h.
  
  
  CONCLUSIONS
  Treatment with DA-8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post-ejaculatory interval in rats. Furthermore, DA-8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA-8031 as an "on-demand" agent for premature ejaculation.
authors: Research Institute of Dong-A Pharmaceutical Company, Yong-in, Kyoung-gi, South Korea; College of Pharmacy, Ajou University, Yeongtong, Suwon, South Korea.
authors: Kyung Koo
authors: KK
authors: Kang
authors: Ji Hyun
authors: JH
authors: Sung
authors: Soon Hoe
authors: SH
authors: Kim
authors: Sukhyang
authors: S
authors: Lee
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D061686:Premature Ejaculation / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012725:Sexual Behavior / Q000187:drug effects*
chemical_list: D001572:Benzofurans; C559089:DA 8031
keywords: DA-8031; animals; premature ejaculation; sexual behavior