title: Cognitive profiles of three clusters of patients with a first-episode psychosis.
abstract: OBJECTIVE
  The primary objective was to identify specific groups of patients with a first-episode psychosis based on family history, obstetric complications, neurological soft signs, and premorbid functioning. The secondary objective was to relate these groups with cognitive variables.
  
  
  METHODS
  A total of 62 first-episode psychoses were recruited from adult and child and adolescent mental health services. The inclusion criteria were patients between 7 and 65 years old (real range of the samples was 13-35 years old), two or more psychotic symptoms and less than one year from the onset of the symptoms. Premorbid functioning (PAS), soft signs (NES), obstetric complications and a neuropsychological battery (CPT, TMTA/TMTB, TAVEC/TAVECI, Stroop, specific subtest of WAIS-III/WISC-IV) were administered.
  
  
  RESULTS
  We found three clusters: 1) higher neurodevelopment contribution (N=14), 2) higher genetic contribution (N=30), and 3) lower neurodevelopment contribution (N=18). Statistical differences were found between groups in TMTB, learning curve of the TAVEC, digits of the WAIS and premorbid estimated IQ, the cluster 1 being the most impaired.
  
  
  CONCLUSIONS
  A cluster approach could differentiate several groups of patients with different cognitive performance. Neuropsychological interventions, as cognitive remediation, should be addressed specifically to patients with more impaired results.
authors: Parc Sanitari Sant Joan de Déu. Sant Boi de Llobregat (Barcelona), CIBERSAM, Spain. Electronic address: sochoa@pssjd.org.
authors: Susana
authors: S
authors: Ochoa
authors: Elena
authors: E
authors: Huerta-Ramos
authors: Ana
authors: A
authors: Barajas
authors: Raquel
authors: R
authors: Iniesta
authors: Montserrat
authors: M
authors: Dolz
authors: Iris
authors: I
authors: Baños
authors: Bernardo
authors: B
authors: Sánchez
authors: Janina
authors: J
authors: Carlson
authors: Alexandrina
authors: A
authors: Foix
authors: Trinidad
authors: T
authors: Pelaez
authors: Marta
authors: M
authors: Coromina
authors: Marta
authors: M
authors: Pardo
authors: Judith
authors: J
authors: Usall
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016000:Cluster Analysis; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology; D055815:Young Adult
keywords: Cluster analysis; Family history; First-episode psychosis; Neurodevelopment; Neuropsychology