title: The role of calcium phosphate in the development of Randall's plaques.
abstract: Results of research carried out during recent years have shown that papillary subepithelial and intratubular deposits of calcium phosphate have important roles in the formation of calcium oxalate stones. In this article, the mechanisms of calcium oxalate stone formation are briefly reviewed and the background to formation of Randall's plaques type I and II discussed. Although some of the conclusions are difficult to prove, it stands to reason that improved understanding of how calcium phosphate is deposited in the interstitial tissue as well as in the collecting ducts will be of great importance for design of rational and individualized recurrence prevention.
authors: Division of Urology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Stockholm, Sweden, hans-goran.tiselius@telia.com.
authors: Hans-Göran
authors: HG
authors: Tiselius
mesh_terms: D002129:Calcium Oxalate / Q000737:chemistry / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism*; D003460:Crystallization; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology* / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D008954:Models, Biological
chemical_list: D002130:Calcium Phosphates; D002129:Calcium Oxalate; C020243:calcium phosphate
references: Oxid Med Cell Longev. 2013;2013:462361
references: 23840917
references: Calcif Tissue Int. 1992 May;50(5):391-6
references: 1596774
references: Ann Urol (Paris). 1995;29(6-7):351-4
references: 8687171
references: J Am Soc Nephrol. 1999 Nov;10 Suppl 14:S364-70
references: 10541265
references: Urol Res. 2010 Jun;38(3):147-60
references: 20411383
references: J Urol. 1975 Oct;114(4):500-7
references: 1235369
references: Pediatr Nephrol. 2010 May;25(5):831-41
references: 19198886
references: Am J Physiol. 1996 Apr;270(4 Pt 2):F604-13
references: 8967338
references: Urol Res. 1993 May;21(3):175-80
references: 8342251
references: Eur Urol. 1993;24(3):381-6
references: 8262107
references: J Urol. 1985 Mar;133(3):490-4
references: 3974005
references: Clin Chim Acta. 1995 Jul 31;239(1):1-11
references: 7586581
references: Am J Physiol. 1992 Apr;262(4 Pt 2):F622-30
references: 1566875
references: Am J Physiol Renal Physiol. 2008 Nov;295(5):F1286-94
references: 18715937
references: BJU Int. 2010 Jan;105(2):242-5
references: 19549258
references: Urol Res. 1999 Dec;27(6):417-25
references: 10651129
references: Nephron Physiol. 2011;119(4):p49-53
references: 21952643
references: Urol Res. 2009 Aug;37(4):181-92
references: 19444436
references: Urol Res. 2001 Dec;29(6):417-22
references: 11828996
references: Urology. 1996 Sep;48(3):343-6
references: 8804483
references: Kidney Int. 2001 Jan;59(1):169-78
references: 11135069
references: Kidney Int. 2003 Dec;64(6):2150-4
references: 14633137
references: J Urol. 1999 May;161(5):1685-8
references: 10210440
references: Scanning Microsc. 1996;10(2):471-84; discussion 484-6
references: 9813625
references: Urol Res. 2010 Aug;38(4):239-47
references: 20625890
references: J Urol. 2000 Jul;164(1):230-6
references: 10840465
references: Urol Res. 2009 Feb;37(1):11-7
references: 19066874
references: Braz J Med Biol Res. 2002 Oct;35(10):1165-72
references: 12424489
references: Nephron Exp Nephrol. 2004;98(2):e55-60
references: 15499208
references: Clin J Am Soc Nephrol. 2011 Aug;6(8):2083-92
references: 21825103
references: Med Hypotheses. 1992 Dec;39(4):360-3
references: 1494324
references: World J Urol. 1997;15(4):244-51
references: 9280053
references: Can J Surg. 1979 Nov;22(6):527-9
references: 497925
references: Front Biosci. 2004 May 01;9:1450-82
references: 14977559
references: Urol Res. 1997;25(2):153-9
references: 9144885
references: Urol Res. 1999 Dec;27(6):397-403
references: 10651126
references: J Clin Invest. 2003 Mar;111(5):607-16
references: 12618515
references: Urol Res. 2011 Aug;39(4):231-43
references: 21246193
references: Miner Electrolyte Metab. 1994;20(6):393-8
references: 7783702
references: Ann Clin Biochem. 1992 Jan;29 ( Pt 1):59-63
references: 1536527
references: Invest Urol. 1978 May;15(6):442-8
references: 649291
references: Kidney Int. 1994 Sep;46(3):847-54
references: 7996806
references: Br J Urol. 1983 Feb;55(1):95-9
references: 6824873
references: J Am Soc Nephrol. 1999 Nov;10 Suppl 14:S371-5
references: 10541266
references: Int J Nanomedicine. 2008;3(1):105-15
references: 18488421
references: Trans Am Clin Climatol Assoc. 1984;95:183-90
references: 6679136
references: Kidney Int. 2006 Apr;69(8):1313-8
references: 16614720
references: Clin Sci. 1972 Oct;43(4):499-506
references: 4653589
references: Invest Urol. 1978 May;15(6):449-51
references: 649292
references: Urology. 1998 Dec;52(6):988-94
references: 9836542
references: Kidney Int. 2002 Dec;62(6):2062-72
references: 12427130
references: Invest Urol. 1981 Mar;18(5):358-63
references: 7203960
references: Anat Rec (Hoboken). 2007 Oct;290(10):1315-23
references: 17724713
references: Urol Res. 2012 Apr;40(2):95-112
references: 22213019