title: Oxidative stress and immune thrombocytopenia.
abstract: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased platelet destruction or decreased platelet production. The mechanism of the disease has been extensively studied so that we now have a much improved understanding of the pathophysiology; however, the trigger of the autoimmunity remains unclear. More recently, oxidative stress was identified to be involved in the pathogenesis of ITP and provides a new hypothesis for the initiation of autoimmunity in patients with ITP. In this review, oxidative stress and its impact on autoimmunity, particularly ITP, will be covered.
authors: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
authors: Bing
authors: B
authors: Zhang
authors: James L
authors: JL
authors: Zehnder
mesh_terms: D000818:Animals; D015551:Autoimmunity; D006801:Humans; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013921:Thrombocytopenia / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species