title: [Multiple sclerosis and pregnancy].
abstract: Multiple sclerosis will usually calm down during pregnancy, but the number of relapses again increases immediately after childbirth. Among the conventional immunomodulatory drugs, there is experience already for over 15 years of the use of interferon-beta and glatiramer. No indications of harmful effects on the fetus have been noted, and interferon-beta and glatiramer can very likely be safely used until the beginning of pregnancy. Fingolimod is suspected to be harmful for fetal development, and the use of this drug should be stopped no later than two months before discontinuing the contraception.
authors: Turun yliopistollinen keskussairaala, neurotoimialue ja Medbase Oy, Turku
authors: Jori
authors: J
authors: Ruuskanen
authors: Heli
authors: H
authors: Malm
authors: Laura
authors: L
authors: Airas
mesh_terms: D005260:Female; D005333:Fetus / Q000187:drug effects; D000068876:Fingolimod Hydrochloride; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016899:Interferon-beta / Q000009:adverse effects / Q000627:therapeutic use; D008431:Maternal-Fetal Exchange; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology*; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011409:Propylene Glycols / Q000009:adverse effects / Q000627:therapeutic use; D012008:Recurrence; D013110:Sphingosine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D011409:Propylene Glycols; D000068717:Glatiramer Acetate; D016899:Interferon-beta; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine