title: The role of cyclin D1 in response to long-term exposure to ionizing radiation.
abstract: The health-related hazards resulting from long-term exposure to radiation remain unknown. Thus, an appropriate molecular marker is needed to clarify these effects. Cyclin D1 regulates the cell cycle transition from the G 1 phase to the S phase. Cyclin D1 is degraded as a G1/S checkpoint after 10 Gy of single acute radiation exposure, whereas conversely, cyclin D1 is stabilized when human tumor cells are exposed to fractionated radiation (FR) with 0.5 Gy of x-rays for 31 d. In this article, we review new findings regarding cyclin D1 overexpression in response to long-term exposure to FR. Cyclin D1 overexpression is associated with induction of genomic instability in irradiated cells. Therefore, repression of cyclin D1 expression is likely to cancel the harmful effects of long-term exposure to FR. Thus cyclin D1 may be a marker of long-term exposure to radiation and is a putative molecular radioprotection target for radiation safety.
authors: Department of Environmental Health; National Institute of Public Health 2-3-6 Minami; Wako, Saitama, Japan.
authors: Tsutomu
authors: T
authors: Shimura
authors: Manabu
authors: M
authors: Fukumoto
authors: Naoki
authors: N
authors: Kunugita
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D019938:Cyclin D1 / Q000378:metabolism*; D025461:Feedback, Physiological / Q000528:radiation effects; D006801:Humans; D011836:Radiation Tolerance / Q000528:radiation effects; D011839:Radiation, Ionizing; D013997:Time Factors
chemical_list: D019938:Cyclin D1
keywords: AKT; Cyclin D1; double-strand breaks; long-term fractionated radiation; radioprotection
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