title: [Warfarin - its synthesis and properties in a twenty-year retrospective*].
abstract: The review paper deals with some aspects of warfarin history and its use, at the beginning as a rodenticide and later as an anticoagulant. It describes its principal physical-chemical properties and it analyzes schematically the possibilities of its preparation by both selective and non-selective synthesis from coumarin derivatives. A survey of syntheses and its results are tabulated, including the literary references, and the paper is concluded with an evaluation of the prospects of this agent in comparison with alternative anticoagulants and its advantages, disadvantages and prospects.
authors: Interna Klinika SZU, Limbova, Bratislava, Slovenska Republika.
authors: Eva
authors: E
authors: Milatová
authors: Viktor
authors: V
authors: Milata
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use; D003374:Coumarins / Q000737:chemistry; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012378:Rodenticides / Q000138:chemical synthesis / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use; D014859:Warfarin / Q000138:chemical synthesis / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D012378:Rodenticides; D014859:Warfarin