title: Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.
abstract: Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.
authors: Radiochemistry and Biomarker Development Unit, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria; Department of Inorganic Chemistry, University of Vienna, A-1090 Vienna, Austria.
authors: Christina
authors: C
authors: Rami-Mark
authors: Johanna
authors: J
authors: Ungersboeck
authors: Daniela
authors: D
authors: Haeusler
authors: Lukas
authors: L
authors: Nics
authors: Cecile
authors: C
authors: Philippe
authors: Markus
authors: M
authors: Mitterhauser
authors: Matthaeus
authors: M
authors: Willeit
authors: Rupert
authors: R
authors: Lanzenberger
authors: Georgios
authors: G
authors: Karanikas
authors: Wolfgang
authors: W
authors: Wadsak
keywords: Carbon-11; Grignard reaction; Loop method; [(11)C]-(+)-PHNO; [carbonyl-(11)C] WAY 100635
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