title: Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes.
abstract: OBJECTIVE
  Urinary adiponectin (u-adiponectin) excretion has been suggested to reflect early glomerular damage. Inspired by this, we studied the levels of u-adiponectin in type 1 diabetic patients with different levels of urinary albumin excretion (UAE).
  
  
  METHODS
  U-adiponectin was analysed by ELISA in type 1 diabetic patients: Fifty-eight with normoalbuminuria (<30mg albumin/24h), 43 with persistent microalbuminuria (30-300mg/24h) and 44 with persistent macroalbuminuria (>300mg/24h). For comparison, a control group of 55 healthy individuals was included.
  
  
  RESULTS
  U-adiponectin increased with increasing levels of UAE (p<0.01). U-adiponectin median (interquartile range): Normoalbuminuria 0.38 (0.14-1.31), microalbuminuria 1.12 (0.20-2.68), macroalbuminuria 9.20 (1.10-23.35) and controls 0.09 (0.06-0.24) μg/g creatinine. Levels were unrelated to sex, age, cholesterol, diastolic BP and BMI. U-adiponectin was weakly associated with increasing systolic BP and HbA1c (r(2)<0.1, p<0.05), but strongly related to increasing UAE (r(2)=0.57, p<0.001) and decreasing eGFR (r(2)=0.26, p<0.001). The relationship between UAE and u-adiponectin was significant in all groups and independent of eGFR, BMI, BP and HbA1c. Furthermore, u-adiponectin was associated with markers of tubular damage (p<0.01).
  
  
  CONCLUSIONS
  U-adiponectin rises with increasing levels of UAE in patients with type 1 diabetes. This is in accordance with the hypothesis that loss of adiponectin may reflect glomerular and/or tubular damage.
authors: Steno Diabetes Center, Gentofte, Denmark; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. Electronic address: andejors@rm.dk.
authors: Anders
authors: A
authors: Jorsal
authors: Emilie Hein
authors: EH
authors: Petersen
authors: Lise
authors: L
authors: Tarnow
authors: Georg
authors: G
authors: Hess
authors: Dietmar
authors: D
authors: Zdunek
authors: Jan
authors: J
authors: Frystyk
authors: Allan
authors: A
authors: Flyvbjerg
authors: Maria
authors: M
authors: Lajer
authors: Peter
authors: P
authors: Rossing
mesh_terms: D052242:Adiponectin / Q000652:urine*; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000453:epidemiology / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: Adiponectin; Albuminuria; Diabetes and kidney disease