title: [The multifactorial genesis of left ventricle remodeling in patients with essential arterial hypertension].
abstract: We examined 122 patients (70 men and 52 women, mean age 56.17+/-1.4 years) with essential hypertension (EH) by echocardiography, radionuclide and radioimmune methods. In 43 patients carotid-femoral pulse wave velocity (PWV) was evaluated by means of the Complier method. In patients with stage I EH cardiac index was significantly increased. This parameter decreased with stabilization of blood pressure while total peripheral resistance (TPR) progressively rose. Pulmonary blood volume was high and volume of circulating blood was normal. Concentration of renin in patients with I-II stages of EH was either normal or high, while in patients with stage III EH it was low. The aldosterone level was significantly increased in all stages of EH. The prevalent geometric type of left ventricular (LV) remodeling in patients with EH was concentric hypertrophy (62.8%). Eccentric LV hypertrophy (LVH) was observed in 22.1% of patients. PWV was increased in all patients but more apparently in patients with stage III EH. Associations were found between PWV and heart rate, hemodynamic, hormonal, cardiac and vascular structural parameters. Degrees of these associations depended on stage of EH. Conclusion. Genesis of LVH and LV remodeling in patients with EH is multifactorial. Hemodynamic and hormonal factors produce double effect on the heart inducing volume-dependent and pressure-dependent LVH.
authors: S V
authors: SV
authors: Gurgerian
authors: S Kh
authors: SKh
authors: Vatinian
mesh_terms: D001794:Blood Pressure; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling / Q000502:physiology*