title: Outcomes after tongue-lip adhesion or mandibular distraction osteogenesis in infants with Pierre Robin sequence and severe airway obstruction.
abstract: The objective was to review and compare outcomes after tongue-lip adhesion (TLA) and mandibular distraction osteogenesis (MDO) in infants with severe breathing difficulties related to Pierre Robin sequence (PRS). A single-centre retrospective (2002-2012) study was carried out; 18 infants with severe breathing difficulties related to PRS resistant to conservative treatment, who underwent TLA or MDO to correct airway obstruction, were enrolled. The primary outcome measures were successful weaning from respiratory support and resumption of full oral feeding. Nine underwent TLA and nine MDO. Eight of the nine infants who underwent MDO and all those treated with TLA were successfully weaned from respiratory support. After discharge, residual respiratory distress was diagnosed more commonly after TLA than after MDO (6/9 vs 1/9, P=0.050). Infants resumed oral feeding sooner after MDO than after TLA (mean days after surgery to full oral feeds 44±24 vs 217±134, P<0.003). The length of hospital stay was longer for infants treated with MDO than for those treated with TLA. The rate of complications was similar. Infants with severe airway obstruction related to PRS can benefit safely from either TLA or MDO. Although MDO lengthens the time to discharge, this option stabilizes airway patency of infants with PRS more efficiently and achieves full oral feeding more rapidly than TLA.
authors: Pediatric Emergency and Intensive Care, Sapienza University of Rome, Umberto I Policlinico, Rome, Italy. Electronic address: p.papoff@libero.it.
authors: P
authors: P
authors: Papoff
authors: G
authors: G
authors: Guelfi
authors: R
authors: R
authors: Cicchetti
authors: E
authors: E
authors: Caresta
authors: D A
authors: DA
authors: Cozzi
authors: C
authors: C
authors: Moretti
authors: F
authors: F
authors: Midulla
authors: S
authors: S
authors: Miano
authors: C
authors: C
authors: Cerasaro
authors: P
authors: P
authors: Cascone
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay; D008046:Lip / Q000601:surgery*; D008297:Male; D008334:Mandible / Q000002:abnormalities* / Q000601:surgery; D019857:Osteogenesis, Distraction / Q000379:methods*; D010855:Pierre Robin Syndrome / Q000150:complications / Q000601:surgery*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D014059:Tongue / Q000601:surgery*; D016896:Treatment Outcome
keywords: Airway obstruction; Mandibular distraction; Pierre Robin sequence; Tongue–lip adhesion