title: In vitro evaluation of a novel topical cream for vitiligo and psoriasis that selectively delivers NB-UVB therapy when exposed to sunlight.
abstract: Ultraviolet-B (UVB) phototherapy is a well-established mode of treatment for several types of dermatological disease. For psoriasis and vitiligo, narrow band UVB (NB-UVB) phototherapy is an effective therapy, demonstrating greater efficacy and safety compared to broadband UVB or psoralen plus UVA treatments. While the treatment efficacy of NB-UVB artificial light sources is well documented, the long term time and cost commitment of the therapy remains a barrier to treatment adherence. Natural sunlight is an ideal source of accessible UVB radiation; however, exposure to natural sunlight generally results in erythema prior to the accumulation of sufficient dosage of therapeutic wavelengths of UVB. This communication describes a novel topical cream designed to selectively deliver NB-UVB therapy when exposed to sunlight. The topical cream when combined with natural sunlight could offer patients a more convenient phototherapy option for psoriasis and vitiligo, potentially increasing patient compliance.
authors: Applied Biology, Irvine, California.
authors: John
authors: J
authors: McCoy
authors: Andy
authors: A
authors: Goren
authors: Torello
authors: T
authors: Lotti
mesh_terms: D000279:Administration, Cutaneous; D006801:Humans; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects*; D011565:Psoriasis / Q000628:therapy*; D013056:Spectrophotometry, Ultraviolet; D013472:Sunlight; D014467:Ultraviolet Therapy / Q000379:methods*; D014820:Vitiligo / Q000175:diagnosis / Q000628:therapy*
chemical_list: D017319:Photosensitizing Agents
keywords: phototherapy; psoriasis; vitiligo