title: Synthesis, characterization and biological activity of three square-planar complexes of Ni(II) with ethyl (2E)-2-[2-(diphenylphosphino)benzylidene]hydrazinecarboxylate and monodentate pseudohalides.
abstract: Three square-planar complexes of nickel(II) with the tridentate condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate, and monodentate pseudohalides, have been synthesized. Their crystal structures have been determined. All the complexes showed a significant antifungal activity, while only the azido complex displayed antibacterial activity. All the complexes were cytotoxic to a panel of six tumor cell lines, the azido complex showing a similar activity as cisplatin to leukemia cell line K562 and lower toxicity to normal MRC-5 cells than that anticancer agent. The complexes interfered with cell cycle of tumor cells and induced plasmid DNA cleavage.
authors: Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
authors: Milica
authors: M
authors: Milenković
authors: Alessia
authors: A
authors: Bacchi
authors: Giulia
authors: G
authors: Cantoni
authors: Jovana
authors: J
authors: Vilipić
authors: Dušan
authors: D
authors: Sladić
authors: Miroslava
authors: M
authors: Vujčić
authors: Nevenka
authors: N
authors: Gligorijević
authors: Katarina
authors: K
authors: Jovanović
authors: Siniša
authors: S
authors: Radulović
authors: Katarina
authors: K
authors: Anđelković
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004269:DNA, Bacterial / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry*; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D002264:Carboxylic Acids; D056831:Coordination Complexes; D004269:DNA, Bacterial; D006834:Hydrazines; D010720:Phosphines; D009532:Nickel; C044646:phosphine
keywords: Antimicrobial activity; Cytotoxicity; Nickel(II) complexes; Pseudohalides; X-ray crystal structures