title: Clear castable polyurethane elastomer for fabrication of microfluidic devices.
abstract: Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting; however, partitioning of small hydrophobic molecules into the bulk of PDMS hinders industrial acceptance of PDMS microfluidic devices for chemical processing and drug development applications. Here we describe an attractive alternative material that is similar to PDMS in terms of optical transparency, flexibility and castability, but that is also resistant to absorption of small hydrophobic molecules.
authors: Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu.
authors: Karel
authors: K
authors: Domansky
authors: Daniel C
authors: DC
authors: Leslie
authors: James
authors: J
authors: McKinney
authors: Jacob P
authors: JP
authors: Fraser
authors: Josiah D
authors: JD
authors: Sliz
authors: Tiama
authors: T
authors: Hamkins-Indik
authors: Geraldine A
authors: GA
authors: Hamilton
authors: Anthony
authors: A
authors: Bahinski
authors: Donald E
authors: DE
authors: Ingber
mesh_terms: D000042:Absorption; D004396:Coloring Agents / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D055620:Optical Phenomena; D010126:Ozone / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D004396:Coloring Agents; D011140:Polyurethanes; D010126:Ozone
references: J Pharm Pharmacol. 1987 Mar;39(3):236-8
references: 2883293
references: Integr Biol (Camb). 2012 May;4(5):461-70
references: 22388577
references: Int J Pharm. 2008 Mar 3;351(1-2):158-64
references: 17980981
references: Lab Chip. 2006 Dec;6(12):1484-6
references: 17203151
references: Electrophoresis. 2003 Nov;24(21):3563-76
references: 14613181
references: Biomaterials. 2009 Oct;30(28):5241-50
references: 19545891
references: Lab Chip. 2011 Jun 7;11(11):1962-7
references: 21503367
references: Int J Nanomedicine. 2012;7:3143-54
references: 22787403
references: Nature. 2006 Jul 27;442(7101):368-73
references: 16871203
references: Anal Chem. 2009 May 15;81(10):3714-22
references: 19382754
references: Nat Rev Drug Discov. 2007 Nov;6(11):881-90
references: 17971784
references: Ann Biomed Eng. 2012 Sep;40(9):1862-73
references: 22484830
references: J Biomater Appl. 2002 Apr;16(4):327-40
references: 12099511
references: Lab Chip. 2012 Jun 21;12(12):2156-64
references: 22555377
references: Lab Chip. 2012 Jun 21;12(12):2165-74
references: 22434367
references: Science. 2010 Jun 25;328(5986):1662-8
references: 20576885
references: Lab Chip. 2009 Jun 7;9(11):1631-7
references: 19458873