title: Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults.
abstract: Hypovitaminosis D is highly prevalent in type 2 diabetes. The aim of this study is to determine the serum levels of 25-hydroxyvitamin D [25(OH)D] in type 2 diabetic patients with and without mild cognitive impairment (MCI), and examine the relationship of 25(OH)D and MCI with other clinical factors. One hundred and sixty-five diabetic patients were enrolled in this study. Among whom, 95 patients were considered as MCI [Montreal Cognitive Assessment score (MoCA) < 26] and the other 70 as no MCI (MoCA ≥ 26). Subjects were assessed clinically. Diabetic patients with MCI had a longer duration of DM, fewer years of education, elevated fasting blood glucose (FBG), resistant index (RI) of carotid, and lower levels of 25(OH)D {[17.35 (13.02-25.92) vs 28.00 (19.67-34.30)] ng/ml, P < 0.001}. The MoCA score was positively correlated with log10[25(OH)D], education year, and inversely correlated with duration of DM, history of hypertension, intima-media thickness (IMT), FBG, max-RI, and min-RI. Log10[25(OH)D] was positively correlated with MoCA score, and inversely correlated with IMT, in multivariate regression analysis adjusted for age, sex, and education year, 25(OH)D (β = 0.210, P = 0.003), history of hypertension (β = -0.191, P = 0.007), IMT (β = -0.194, P = 0.007), and FBG (β = -0.157, P = 0.026) independently predicted MoCA score. In conclusion, our results suggest that levels of serum 25(OH)D are inversely associated with the cognitive impairment in diabetic patients. Vitamin D may be a potential protective factor for cognitive impairment in patients with type 2 diabetes.
authors: Department of Endocrinology, Shanghai Pudong New Area People's Hospital, No.490, South Chuanhuan Road, Shanghai, China.
authors: Rui-hua
authors: RH
authors: Chen
authors: Xiao-hui
authors: XH
authors: Zhao
authors: Zhe
authors: Z
authors: Gu
authors: Pei-li
authors: PL
authors: Gu
authors: Bin
authors: B
authors: Zhou
authors: Zhen-hong
authors: ZH
authors: Zhu
authors: Lin-yan
authors: LY
authors: Xu
authors: Yu-feng
authors: YF
authors: Zou
authors: Xiao-zhen
authors: XZ
authors: Jiang
mesh_terms: D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood* / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000523:psychology
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
references: Neurology. 2012 Sep 25;79(13):1397-405
references: 23008220
references: Endocrine. 2013 Jun;43(3):618-25
references: 23015273
references: Clin Endocrinol (Oxf). 2006 Nov;65(5):593-7
references: 17054459
references: Arch Neurol. 1999 Mar;56(3):303-8
references: 10190820
references: J Neurol Neurosurg Psychiatry. 2006 Jun;77(6):714-8
references: 16549412
references: Atherosclerosis. 2012 Oct;224(2):506-10
references: 22854188
references: Eur J Neurol. 2009 Oct;16(10):1083-9
references: 19659751
references: Int J Clin Pract. 2010 Feb;64(3):351-5
references: 19863680
references: J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):59-65
references: 21041201
references: Curr Drug Targets. 2011 Jan;12(1):61-87
references: 20795936
references: Endocrine. 2013 Oct;44(2):465-72
references: 23340918
references: Neuropsychobiology. 2010 Aug;62(3):139-50
references: 20628264
references: Diabetes Care. 2013 Jun;36(6):1720-5
references: 23404303
references: Atherosclerosis. 2012 Jun;222(2):490-4
references: 22460047
references: J Alzheimers Dis. 2009;17(3):703-17
references: 19433889
references: Trends Endocrinol Metab. 2002 Apr;13(3):100-5
references: 11893522
references: Diabetes Metab. 2010 Apr;36(2):91-6
references: 20189425
references: N Engl J Med. 2007 Jul 19;357(3):266-81
references: 17634462
references: Diabetologia. 2005 Dec;48(12):2460-9
references: 16283246
references: Ann Endocrinol (Paris). 2012 Jun;73(3):208-12
references: 22704263
references: J Nutr Health Aging. 2012 Oct;16(10):898-901
references: 23208029
references: Endocrine. 2011 Oct;40(2):273-9
references: 21861245
references: J Am Geriatr Soc. 2005 Apr;53(4):695-9
references: 15817019
references: Dement Geriatr Cogn Disord. 2012;33(5):297-305
references: 22759681
references: J Neurol Sci. 2012 Nov 15;322(1-2):152-6
references: 22871541
references: BMJ. 2010 Aug 05;341:c3885
references: 20688841
references: Diabetes Care. 2008 Oct;31(10):2006-12
references: 18628568