title: Hallucinogen-persisting perception disorder.
abstract: A 33-year-old female patient developed a hallucinogen-persisting perception disorder (HPPD) after lysergic acid diethylamide (LSD) abuse for a year at the age of 18. Specifically, she reported after images, perception of movement in her peripheral visual fields, blurring of small patterns, halo effects, and macro- and micropsia. Previous treatment with antidepressants and risperidone failed to ameliorate these symptoms. Upon commencing drug therapy with lamotrigine, these complex visual disturbances receded almost completely. Based on its hypothesized neuroprotective and mood-stabilizing effects, the antiepileptic lamotrigine may offer a promising new approach in the treatment of HPPD.
authors: Department of Psychiatry, Christophsbad, Göppingen, Germany.
authors: Leo
authors: L
authors: Hermle
authors: Melanie
authors: M
authors: Simon
authors: Martin
authors: M
authors: Ruchsow
authors: Martin
authors: M
authors: Geppert
keywords: Flashback; LSD; hallucinogen-persisting perception disorder
references: Drug Alcohol Depend. 2003 Mar 1;69(2):109-19
references: 12609692
references: Epilepsy Res. 2001 Sep;46(3):205-23
references: 11518623
references: J Clin Psychopharmacol. 1996 Jun;16(3):238-41
references: 8784656
references: J Pediatr. 1994 Nov;125(5 Pt 1):817-9
references: 7965440
references: Eur Psychiatry. 2005 Aug;20(5-6):458-60
references: 15963699
references: Isr J Psychiatry Relat Sci. 2002;39(2):100-3
references: 12227224
references: Int Clin Psychopharmacol. 2000 Jan;15(1):35-7
references: 10836284
references: Lancet. 1955 May 21;268(6873):1078-9
references: 14368965
references: Neuropsychopharmacology. 1996 Jun;14(6):425-36
references: 8726753
references: J Clin Psychiatry. 2001 Oct;62(10):826-7
references: 11816874
references: J Psychopharmacol. 2003 Mar;17(1):103-5
references: 12680746
references: J Nerv Ment Dis. 1982 Apr;170(4):217-23
references: 7062008
references: Am J Psychiatry. 1997 Mar;154(3):437
references: 9054801
references: Biol Psychiatry. 1992 Dec 1;32(11):976-91
references: 1467389
references: Isr J Psychiatry Relat Sci. 2002;39(1):57-60
references: 12013711
references: Br J Psychiatry. 1982 May;140:518-20
references: 6980680
references: Isr J Psychiatry Relat Sci. 2001;38(2):133-6
references: 11475916
references: Arch Gen Psychiatry. 1983 Aug;40(8):884-9
references: 6135405
references: Curr Psychiatry Rep. 2003 Oct;5(5):347-54
references: 13678554
references: Int Clin Psychopharmacol. 2003 Mar;18(2):101-5
references: 12598822
references: Fortschr Neurol Psychiatr. 2008 Jun;76(6):334-42
references: 18512184
references: J Clin Psychiatry. 1997 Feb;58(2):85
references: 9062378
references: J Clin Psychopharmacol. 1998 Dec;18(6):487-8
references: 9864086
references: Neuropsychopharmacology. 1996 Apr;14(4):285-98
references: 8924196
references: J Clin Psychopharmacol. 2001 Jun;21(3):343-4
references: 11386500
references: J Nerv Ment Dis. 1984 May;172(5):273-8
references: 6716092