title: Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition.
abstract: Recent clinical data indicates that hemodynamic changes caused by cardiovascular diseases such as atherosclerosis, heart failure, and hypertension affect cognition. Yet, the underlying mechanisms of the resulting vascular cognitive impairment (VCI) are poorly understood. One reason for the lack of mechanistic insights in VCI is that research in dementia primarily focused on Alzheimer's disease models. To fill in this gap, we critically reviewed the published data and various models of VCI. Typical findings in VCI include reduced cerebral perfusion, blood-brain barrier alterations, white matter lesions, and cognitive deficits, which have also been reported in different cardiovascular mouse models. However, the tests performed are incomplete and differ between models, hampering a direct comparison between models and studies. Nevertheless, from the currently available data we conclude that a few existing surgical animal models show the key features of vascular cognitive decline, with the bilateral common carotid artery stenosis hypoperfusion mouse model as the most promising model. The transverse aortic constriction and myocardial infarction models may be good alternatives, but these models are as yet less characterized regarding the possible cerebral changes. Mixed models could be used to study the combined effects of different cardiovascular diseases on the deterioration of cognition during aging.
authors: 1] Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands [2] Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Diewertje I
authors: DI
authors: Bink
authors: Katja
authors: K
authors: Ritz
authors: Eleonora
authors: E
authors: Aronica
authors: Louise
authors: L
authors: van der Weerd
authors: Mat J A P
authors: MJ
authors: Daemen
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D004195:Disease Models, Animal; D051379:Mice
references: Dement Geriatr Cogn Disord. 2004;18(2):207-16
references: 15211077
references: Mol Neurodegener. 2009 Oct 24;4:42
references: 19852847
references: J Cereb Blood Flow Metab. 2006 Feb;26(2):253-62
references: 16079792
references: Ann Neurol. 2007 May;61(5):403-10
references: 17328068
references: Stroke. 2011 Sep;42(9):2672-713
references: 21778438
references: Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1104-12
references: 11514276
references: Eur J Heart Fail. 2007 May;9(5):440-9
references: 17174152
references: Behav Brain Res. 2008 Aug 22;191(2):256-65
references: 18466986
references: J Neurosci. 2011 Dec 7;31(49):18185-94
references: 22159130
references: J Cereb Blood Flow Metab. 2005 Jun;25(6):713-21
references: 15703698
references: Stroke. 2004 Nov;35(11):2598-603
references: 15472111
references: Mol Med. 2001 Dec;7(12):810-5
references: 11844869
references: J Neurol Sci. 2009 Oct 15;285(1-2):39-45
references: 19524941
references: Cardiovasc Psychiatry Neurol. 2012;2012:367516
references: 23243502
references: Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1902-9
references: 22556331
references: Brain Behav Immun. 2011 Aug;25(6):1113-22
references: 21356305
references: Neurobiol Aging. 2011 Dec;32(12):2325.e1-6
references: 21194797
references: J Clin Invest. 2010 Feb;120(2):433-45
references: 20071773
references: J Neurosci. 2010 Nov 17;30(46):15337-57
references: 21084591
references: Alzheimers Dement. 2012 Oct;8(5 Suppl):S104-11
references: 22537801
references: J Neurosci Res. 2000 May 15;60(4):559-64
references: 10797559
references: J Cell Sci. 2011 Oct 1;124(Pt 19):3369-80
references: 21896646
references: J Alzheimers Dis. 2010;20(3):855-9
references: 20182039
references: Nat Rev Neurosci. 2012 Nov;13(11):743-57
references: 23047773
references: J Cell Sci. 2011 Jul 1;124(Pt 13):2220-30
references: 21652634
references: J Proteome Res. 2008 Jun;7(6):2246-52
references: 18473452
references: Cell. 1992 Oct 16;71(2):343-53
references: 1423598
references: Mol Cell Biochem. 2006 Oct;291(1-2):205-11
references: 16718361
references: Thromb Haemost. 2007 Apr;97(4):658-64
references: 17393030
references: Stroke. 2004 May;35(5):1203-8
references: 15060322
references: Exp Dermatol. 2012 Feb;21(2):123-9
references: 22229442
references: Behav Brain Res. 2004 Jan 5;148(1-2):167-77
references: 14684257
references: Exp Neurol. 2001 May;169(1):13-22
references: 11312553
references: J Neurochem. 2007 Aug;102(4):1220-31
references: 17472705
references: Stroke. 2010 Dec;41(12):2938-43
references: 20947840
references: Immunology. 2010 Feb;129(2):154-69
references: 20561356
references: Stroke. 2007 Jul;38(7):2136-41
references: 17525390
references: Hypertens Res. 2009 Sep;32(9):816-20
references: 19575014
references: Cell Stem Cell. 2009 Dec 4;5(6):634-45
references: 19951691
references: Stroke. 2012 Dec;43(12):3319-24
references: 23103489
references: Eur J Neurosci. 2001 Nov;14(9):1505-14
references: 11722612
references: Exp Neurol. 1998 Jun;151(2):314-25
references: 9628766
references: Am J Physiol Cell Physiol. 2007 Apr;292(4):C1256-62
references: 16870825
references: NMR Biomed. 2003 Dec;16(8):459-67
references: 14696002
references: J Alzheimers Dis. 2012;32(2):495-511
references: 22810096
references: Prog Neuropsychopharmacol Biol Psychiatry. 1999 Apr;23(3):519-31
references: 10378234
references: Nat Genet. 1997 Nov;17(3):263-4
references: 9354781
references: Neurobiol Aging. 2012 Jan;33(1):205.e19-29
references: 20961666
references: Ann Neurol. 2005 Jun;57(6):789-94
references: 15929050
references: Alzheimers Dement. 2013 Jan;9(1):63-75.e2
references: 23305823
references: Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1143-52
references: 21705678
references: Magn Reson Med. 2008 Sep;60(3):744-8
references: 18727091
references: J Clin Invest. 2000 Dec;106(12):1489-99
references: 11120756
references: Stroke. 2006 Nov;37(11):2816-23
references: 17008622
references: Lab Invest. 2001 Jul;81(7):953-60
references: 11454984
references: J Pineal Res. 2005 Jan;38(1):35-41
references: 15617535
references: J Alzheimers Dis. 2012;32(3):633-42
references: 22842868
references: PLoS One. 2011 Jan 27;6(1):e16567
references: 21305033
references: Stroke. 2005 Oct;36(10):2270-4
references: 16141423
references: Behav Brain Res. 2001 Nov 1;125(1-2):249-59
references: 11682116
references: Neurobiol Aging. 2013 Mar;34(3):679-93
references: 22819135
references: Trends Neurosci. 2007 Sep;30(9):433-9
references: 17765332
references: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4544-9
references: 9539774
references: J Cereb Blood Flow Metab. 2003 Apr;23(4):499-512
references: 12679727
references: J Gerontol A Biol Sci Med Sci. 2006 Oct;61(10):1065-9
references: 17077200
references: Neurobiol Aging. 2009 Feb;30(2):222-8
references: 17673335
references: J Biol Chem. 2011 May 20;286(20):17536-42
references: 21471207
references: Stroke. 2005 May;36(5):1053-8
references: 15817893
references: Stroke. 2007 Oct;38(10):2826-32
references: 17761909
references: Neuropathol Appl Neurobiol. 2009 Apr;35(2):132-46
references: 19077110
references: Brain Res. 2009 Oct 19;1294:202-10
references: 19646974
references: Physiol Behav. 2012 Jun 25;106(4):485-90
references: 22483785
references: Stroke. 2009 May;40(5):1590-6
references: 19265054
references: Neurobiol Aging. 2013 Apr;34(4):1018-31
references: 23084084
references: J Alzheimers Dis. 2011;24(2):269-85
references: 21239853
references: Opt Express. 2011 Oct 10;19(21):20301-15
references: 21997041
references: Stroke. 2004 Jun;35(6):e159-62
references: 15105518
references: J Biol Chem. 2005 Jul 8;280(27):25754-9
references: 15888448
references: Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H1032-43
references: 21186270
references: J Neurosci. 1999 Jun 15;19(12):4867-80
references: 10366621
references: J Cereb Blood Flow Metab. 2008 Jun;28(6):1071-85
references: 18349877
references: Arterioscler Thromb. 1994 Jan;14(1):133-40
references: 8274468
references: J Neuroinflammation. 2012 Jun 18;9:132
references: 22709928
references: Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18787-92
references: 17116874
references: Neurosci Lett. 2011 Feb 4;489(2):84-8
references: 21134418
references: Neuroscience. 2001;108(2):237-47
references: 11734357
references: CNS Neurosci Ther. 2012 Sep;18(9):745-53
references: 22943141
references: J Neurol Sci. 2004 Nov 15;226(1-2):3-7
references: 15537510
references: Stroke. 2010 Jun;41(6):1278-84
references: 20448204
references: J Clin Invest. 2012 Apr;122(4):1377-92
references: 22406537
references: Neurobiol Aging. 2011 Dec;32(12):2324.e7-12
references: 20961660
references: Stroke. 2011 Apr;42(4):1122-8
references: 21393586
references: Resuscitation. 2012 Oct;83(10):1292-7
references: 22370005
references: Cardiovasc Res. 2007 Oct 1;76(1):100-9
references: 17658498
references: Neuroimage. 2001 Dec;14(6):1244-55
references: 11707081
references: Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2081-92
references: 21926346
references: J Neurosci Res. 2009 Apr;87(5):1270-81
references: 18951530
references: Exp Neurol. 2008 Apr;210(2):585-91
references: 18222425
references: Ultrasound Med Biol. 2003 Sep;29(9):1281-9
references: 14553805
references: Front Physiol. 2012 May 10;3:131
references: 22590459
references: Arch Intern Med. 2006 May 8;166(9):1003-8
references: 16682574
references: Neurobiol Dis. 2004 Jun;16(1):212-9
references: 15207278
references: Neurosci Lett. 1999 Apr 23;265(3):218-22
references: 10327170
references: Neuroscience. 1998 Jul;85(1):93-110
references: 9607706
references: Hypertension. 2011 Oct;58(4):635-42
references: 21859961
references: Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2881-8
references: 21940951
references: Int Psychogeriatr. 2003;15 Suppl 1:139-46
references: 16191231
references: Neurosci Res. 2007 Nov;59(3):251-6
references: 17720268
references: Circulation. 2012 Jul 10;126(2):196-206
references: 22668972
references: Nature. 2012 May 16;485(7399):512-6
references: 22622580
references: Neuroscience. 2011 Dec 1;197:99-106
references: 21945034
references: J Clin Invest. 1995 May;95(5):2246-57
references: 7738190
references: Nat Med. 1998 Aug;4(8):934-8
references: 9701246
references: Neuroimage. 2012 Dec;63(4):1807-17
references: 22971548
references: J Clin Invest. 2010 Feb;120(2):472-84
references: 20071776
references: Arch Neurol. 2007 Dec;64(12):1734-40
references: 18071036
references: J Cereb Blood Flow Metab. 2004 Jul;24(7):744-55
references: 15241182
references: J Cardiopulm Rehabil Prev. 2010 Nov-Dec;30(6):401-8
references: 20562712
references: Neurobiol Aging. 2001 Jan-Feb;22(1):9-15
references: 11164271
references: Am J Med Sci. 2002 Jan;323(1):3-10
references: 11814139
references: N Engl J Med. 1987 Sep 17;317(12):734-7
references: 3627182
references: Development. 2011 Oct;138(20):4351-62
references: 21880781
references: PLoS One. 2011;6(7):e22712
references: 21829488
references: Eur Heart J. 2005 Feb;26(3):226-33
references: 15618043
references: J Cereb Blood Flow Metab. 2012 Jul;32(7):1277-309
references: 22293983
references: Neuroreport. 1997 Jul 28;8(11):2505-10
references: 9261817
references: Neurobiol Aging. 2006 Nov;27(11):1632-43
references: 16236385
references: Exp Neurol. 1995 Dec;136(2):107-22
references: 7498401
references: J Neurochem. 2008 Jul;106(1):475-85
references: 18410513
references: Neurodegener Dis. 2008;5(3-4):126-32
references: 18322369
references: Exp Ther Med. 2013 Apr;5(4):1019-1024
references: 23596467
references: Hypertension. 2012 Jul;60(1):188-97
references: 22615109
references: J Clin Invest. 1995 Mar;95(3):1124-32
references: 7883961
references: Eur J Heart Fail. 2007 Oct;9(10):1003-9
references: 17719270
references: Arch Neurol. 2005 Nov;62(11):1734-6
references: 16286548
references: Stroke. 1999 May;30(5):1118-24
references: 10229753
references: J Cereb Blood Flow Metab. 2010 Aug;30(8):1494-503
references: 20234380
references: J Clin Exp Neuropsychol. 1997 Oct;19(5):692-7
references: 9408799
references: BMJ. 1995 Apr 15;310(6985):970-3
references: 7728032
references: Neuron. 2012 Dec 6;76(5):871-85
references: 23217737
references: Neurochem Res. 2009 Feb;34(2):311-5
references: 18607722
references: Acta Neuropathol. 2012 Mar;123(3):381-94
references: 22170742
references: FEBS Lett. 2005 Nov 21;579(28):6411-6
references: 16288750
references: Nat Immunol. 2011 Mar;12(3):204-12
references: 21321594
references: Eur J Heart Fail. 2010 Jan;12(1):4-12
references: 20023039
references: PLoS One. 2011;6(7):e21880
references: 21755005
references: Stroke. 2010 Oct;41(10 Suppl):S129-34
references: 20876488
references: Ann Neurol. 2002 Jan;51(1):113-7
references: 11782990