title: Prognostic indicator for the resection of liver metastasis of colorectal cancer.
abstract: OBJECTIVE
  We investigated the predictive indicator for a good prognosis of surgical resection for liver metastasis of colorectal cancer.
  
  
  METHODS
  Between 1990 and 2009 at our institute, 117 patients underwent 132 hepatic resections for liver metastasis of colorectal cancer. The clinical, pathological, and outcome parameters affecting their prognoses were analyzed. The extent of the liver metastases was subdivided according to the Japanese Classification of Colorectal Carcinoma (JCCRC), and the patients were classified into different grades based on the JCCRC classification and the status of the nodal involvement of the primary tumor.
  
  
  RESULTS
  The median survival time (MST) of the 117 patients was 58 months, and the actuarial survival rates at 1, 3, and 5 years were 92.3, 60.0, and 46.1 %, respectively. A multivariate analysis revealed that the JCCRC Grade classification was an independent prognostic indicator (Grade A vs. B vs. C: MST, 72 vs. 41 vs. 23 months; 5-year survival, 59.0 vs. 38.6 vs. 0 %: p < 0.0001).
  
  
  CONCLUSIONS
  Our findings indicate that the JCCRC Grade classification for liver metastasis of colorectal cancer is a significant prognostic indicator and may be useful for making decisions regarding the treatment of liver metastasis.
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan, ramano@med.osaka-cu.ac.jp.
authors: Ryosuke
authors: R
authors: Amano
authors: Nobuya
authors: N
authors: Yamada
authors: Bunzo
authors: B
authors: Nakata
authors: Kenjiro
authors: K
authors: Kimura
authors: Masakazu
authors: M
authors: Yashiro
authors: Masaichi
authors: M
authors: Ohira
authors: Kosei
authors: K
authors: Hirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology*; D003661:Decision Support Techniques; D005260:Female; D006498:Hepatectomy / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000145:classification / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult
references: J Clin Oncol. 2008 Aug 1;26(22):3672-80
references: 18669451
references: World J Surg. 1995 Jan-Feb;19(1):59-71
references: 7740812
references: Cancer. 1969 Jan;23(1):198-202
references: 5763253
references: Hepatogastroenterology. 2008 Jan-Feb;55(81):173-8
references: 18507101
references: Lakartidningen. 2003 Aug 28;100(35):2684-8
references: 14531128
references: Surgery. 2008 Jun;143(6):706-14
references: 18549886
references: Surg Today. 2012 Jun;42(6):532-5
references: 22139087
references: J Clin Oncol. 2006 Nov 1;24(31):4976-82
references: 17075115
references: J Hepatobiliary Pancreat Surg. 2005;12(1):16-22
references: 15754094
references: Cancer. 1996 Apr 1;77(7):1254-62
references: 8608500
references: Surg Today. 2012 May;42(5):426-30
references: 22094439
references: J Clin Oncol. 1997 Mar;15(3):938-46
references: 9060531
references: Semin Surg Oncol. 1996 Jul-Aug;12(4):219-52
references: 8829283
references: J Hepatobiliary Pancreat Surg. 1999;6(1):39-49
references: 10436236
references: J Surg Oncol. 2008 Oct 1;98(5):371-6
references: 18646038
references: J Hepatobiliary Pancreat Sci. 2012 Jan;19(1):72-84
references: 22020927
references: Lancet. 2000 Mar 25;355(9209):1041-7
references: 10744089
references: J Clin Oncol. 2004 Jan 1;22(1):23-30
references: 14665611
references: N Engl J Med. 2004 Jun 3;350(23):2335-42
references: 15175435
references: Lancet. 2008 Mar 22;371(9617):1007-16
references: 18358928
references: Br J Surg. 1997 Aug;84(8):1136-40
references: 9278662
references: Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21
references: 10493478
references: Br J Surg. 1997 Jul;84(7):977-80
references: 9240140
references: N Engl J Med. 2004 Jun 3;350(23):2343-51
references: 15175436
references: Ann Surg Oncol. 2001 May;8(4):347-53
references: 11352309
references: World J Surg. 2007 Mar;31(3):511-21
references: 17308854
references: World J Surg. 2008 Jan;32(1):93-103
references: 18027020
references: Surgery. 1994 Oct;116(4):703-10; discussion 710-1
references: 7940169
references: Ann Oncol. 2009 Dec;20(12):1964-70
references: 19567451
references: J Clin Oncol. 2008 Apr 20;26(12):2013-9
references: 18421054