title: Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis.
abstract: Study results on the association between RAD51 gene -135G/C polymorphism and risk of myelodysplastic syndrome (MDS) or acute leukemia are inconsistent. A meta-analysis was conducted to identify the association. A systematic search was performed in PubMed, Embase, CNKI, VIP, Wanfang databases to collect all relevant studies until January 2013. Meta-analysis was carried out using fixed/random model by Review Manager 5.1 and STATA10.0. A total of 10 eligible studies with 2,656 patients and 3,725 controls were included in meta-analysis. Significant association was detected between -135G/C polymorphism and increased MDS risk (CC + GC vs. GG: OR = 1.46, 95% CI = 1.11-1.92; CC vs. GC + GG: OR = 2.45, 95% CI = 1.23-4.89), while no association was observed for acute leukemia. Subgroup analysis by subtypes of acute leukemia and ethnicity showed no significant results either. Our meta-analysis indicated that the -135G/C polymorphism might be associated with increased susceptibility of MDS. However, lack of evidence supported association of this polymorphism with acute leukemia. Additional well-designed studies with larger samples are required to verify our results.
authors: West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, People's Republic of China.
authors: Ya-zhou
authors: YZ
authors: He
authors: Xin
authors: X
authors: Hu
authors: Xiao-sa
authors: XS
authors: Chi
authors: Yuan-chuan
authors: YC
authors: Zhang
authors: Xiang-Bing
authors: XB
authors: Deng
authors: Ming-tian
authors: MT
authors: Wei
authors: Zi-qiang
authors: ZQ
authors: Wang
authors: Yan-hong
authors: YH
authors: Zhou
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000208:ethnology / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D051135:Rad51 Recombinase / Q000235:genetics*
chemical_list: D051135:Rad51 Recombinase
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