title: Evaluation of Bacopa monniera for its synergistic activity with rivastigmine in reversing aluminum-induced memory loss and learning deficit in rats.
abstract: The objective of this study was to evaluate the synergistic activity of Bacopa monniera with Rivastigmine against aluminum-chloride (AlCl3)-induced cognitive impairment in rats. Adult male Wistar rats were divided into ten groups (n = 10) and subjected to their assigned treatments for 42 days. On the 20(th) day of the respective drug treatments, all the animals were trained in the Morris water maze (retention latency) and the elevated plus maze (transfer latency). After the initial training, the retention latency (RL) and the transfer latency (TL) were evaluated on the 21(st) and the 42(nd) days of the study. Chronic administration of AlCl3 caused significant memory impairment associated with increased RL in the Morris water maze task and increased TL in the elevated plus maze test. Interestingly, animals treated with oral administration of B. monniera (100 and 200 mg/kg), Rivastigmine (5 mg/kg) or a combination of B. monniera (100 mg/kg) with Rivastigmine (5 mg/kg) showed significant protection against AlCl3-induced memory impairment compared to animal treated with AlCl3per se. Additionally, the neuroprotective effect of B. monniera (100 and 200 mg/kg) was significantly improved when supplemented with Rivastigmine (5 mg/kg). These findings suggest that treatment with a combination of B. monniera with Rivastigmine may be highly beneficial compared to their per-se treatment.
authors: Department of Pharmacology, R&D Center, The Himalaya Drug Company, Makali, Karnataka, India.
authors: Agadi Hiremath
authors: AH
authors: Thippeswamy
authors: Mohamed
authors: M
authors: Rafiq
authors: Gollapalle Lakshminarayana Shastry
authors: GL
authors: Viswantha
authors: Kethaganahalli J
authors: KJ
authors: Kavya
authors: Suryakanth D
authors: SD
authors: Anturlikar
authors: Pralhad S
authors: PS
authors: Patki
mesh_terms: D000535:Aluminum / Q000633:toxicity; D000818:Animals; D034681:Bacopa / Q000737:chemistry*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology*; D048448:Phenylcarbamates / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D000068836:Rivastigmine
chemical_list: D048448:Phenylcarbamates; D010936:Plant Extracts; D000535:Aluminum; D000068836:Rivastigmine
keywords: Bacopa monniera; Morris water maze; aluminum chloride; elevated plus maze; memory impairment; rivastigmine