title: Pentraxin 3 is a local inflammatory marker in atrial fibrillation.
abstract: Increasing evidence indicates that inflammation contributes to the pathogenesis of atrial fibrillation (AF). Pentraxin 3 (PTX3) is produced abundantly in local inflammatory lesions while C-reactive protein (CRP) is produced mainly in the liver. In this study, we investigated whether a local level of PTX3 might be a sensitive marker for the local inflammation of AF. Blood from the periphery and left atrial appendage (LAA) was sampled from 23 patients with AF undergoing pulmonary vein isolation, and from 10 control subjects with Wolff-Parkinson-White syndrome. We measured peripheral and LAA plasma concentrations of CRP, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and PTX3. Plasma PTX3 concentrations in both locations were higher in patients with AF than in control subjects. PTX3 concentrations were significantly higher in the LAA than the periphery in patients with AF (3.7 ± 1.4 vs 3.3 ± 1.2 ng/ml, P < 0.01), but not in control subjects (2.4 ± 0.5 vs 2.4 ± 0.5 ng/ml, not significant). Patients and controls showed no significant differences in CRP, IL-6, or TNF-α concentrations between the periphery and LAA. Interestingly, there was a significant positive correlation between LAA plasma concentrations of PTX3 and left atrial volume (r = 0.55, P < 0.01). These data demonstrate that local PTX3 production in the left atrium might reflect the local inflammation of AF.
authors: Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 2-50-1 Kuramoto, 770-8503, Tokushima, Japan, soeki@clin.med.tokushima-u.ac.jp.
authors: Takeshi
authors: T
authors: Soeki
authors: Sachiko
authors: S
authors: Bando
authors: Etsuko
authors: E
authors: Uematsu
authors: Tomomi
authors: T
authors: Matsuura
authors: Toshiyuki
authors: T
authors: Niki
authors: Takayuki
authors: T
authors: Ise
authors: Kenya
authors: K
authors: Kusunose
authors: Junko
authors: J
authors: Hotchi
authors: Yuka
authors: Y
authors: Ueda
authors: Noriko
authors: N
authors: Tomita
authors: Koji
authors: K
authors: Yamaguchi
authors: Shusuke
authors: S
authors: Yagi
authors: Daiju
authors: D
authors: Fukuda
authors: Yoshio
authors: Y
authors: Taketani
authors: Takashi
authors: T
authors: Iwase
authors: Hirotsugu
authors: H
authors: Yamada
authors: Tetsuzo
authors: T
authors: Wakatsuki
authors: Michio
authors: M
authors: Shimabukuro
authors: Masataka
authors: M
authors: Sata
mesh_terms: D000368:Aged; D020517:Atrial Appendage / Q000276:immunology*; D001281:Atrial Fibrillation / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000032:analysis*; D015854:Up-Regulation; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
references: Heart. 2010 Dec;96(23):1909-14
references: 20965978
references: Circulation. 2001 Dec 11;104(24):2886-91
references: 11739301
references: Circ J. 2010 Feb;74(2):262-70
references: 20009387
references: Circulation. 2003 Dec 16;108(24):3006-10
references: 14623805
references: Circulation. 1997 Aug 19;96(4):1180-4
references: 9286947
references: Heart. 2008 Feb;94(2):200-4
references: 17575330
references: J Cardiol. 2011 Sep;58(2):151-7
references: 21676590
references: Clin Chem Lab Med. 2009;47(4):471-7
references: 19327124
references: Heart Vessels. 2013 Nov;28(6):795-801
references: 23494606
references: Heart Vessels. 2013 Sep;28(5):583-8
references: 23242167
references: Am J Cardiol. 2005 Mar 15;95(6):764-7
references: 15757607
references: Eur Heart J. 2003 Jul;24(14):1373-80
references: 12871695
references: JAMA. 1985 Dec 27;254(24):3449-53
references: 4068186
references: J Am Coll Cardiol. 2004 Jun 2;43(11):2075-82
references: 15172416
references: Circulation. 1998 Sep 8;98(10):946-52
references: 9737513
references: PLoS One. 2012;7(9):e45834
references: 23029266
references: Cardiovasc Pathol. 2011 Jan-Feb;20(1):e27-35
references: 20356766
references: Annu Rev Immunol. 2005;23:337-66
references: 15771574
references: Ann Thorac Surg. 2005 May;79(5):1530-5
references: 15854929
references: Eur Heart J. 2005 Oct;26(20):2083-92
references: 15975993