title: Influence of interleukin-6 gene -174G>C polymorphism on development of atherosclerosis: a meta-analysis of 50 studies involving 33,514 subjects.
abstract: Increasing epidemiological studies have focused on the associations between interleukin-6 (IL-6) gene -174G>C polymorphism and atherosclerotic diseases, but the results are still controversial. This meta-analysis was designed to identify whether this association exists. PubMed, Embase, Web of Science, Cochrane database, Clinicaltrials.gov and Current Controlled Trials, Chinese Clinical Trial Registry, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. The crude odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to estimate the association between the IL-6 gene -174G>C polymorphism and atherosclerosis ( AS ) risk. The subgroup analyses were made on the following: ethnicity, atherosclerotic diseases and source of controls. Finally, 50 studies (15,029 cases and 18,485 controls) were included in this meta-analysis. Overall, no significant association was found between the IL-6 gene -174G>C polymorphism and AS risk (for C allele vs. G allele: OR=1.02, 95% CI=0.94-1.11, p=0.64; for C/C vs. G/G: OR=1.01, 95% CI=0.85-1.21, p=0.88; for C/C vs. C/G+G/G: OR=0.97, 95% CI=0.84-1.12, p=0.68; for C/C+C/G vs. G/G: OR=1.07, 95% CI=0.97-1.17, p=0.18). In the subgroup analyses, significant associations were found between the IL-6 gene -174G>C polymorphism and AS in non-Caucasian group (for CC+CG vs. GG: OR=1.22, 95% CI=1.06-1.41, p=0.005), other atherosclerotic diseases group (for C allele vs. G allele: OR =0.75, 95% CI=0.61-0.93, p=0.008; for C/C vs. G/G: OR=0.56, 95% CI=0.38-0.81, p=0.002; for C/C vs. C/G+G/G: OR=0.60, 95% CI=0.45-0.79, p=0.0004) and population-based group (for C allele vs. G allele: OR=1.09, 95% CI=1.00-1.18, p=0.04; for CC+CG vs. GG: OR=1.15, 95% CI=1.04-1.27, p=0.005). In summary, the present meta-analysis suggests that the IL-6 gene -174G C polymorphism is associated with the susceptibility to AS. However, due to the high heterogeneity in the meta-analysis, the results should be interpreted with caution.
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Yan-Wei
authors: YW
authors: Yin
authors: Jing-Cheng
authors: JC
authors: Li
authors: Meng
authors: M
authors: Zhang
authors: Jing-Zhou
authors: JZ
authors: Wang
authors: Bing-Hu
authors: BH
authors: Li
authors: Yun
authors: Y
authors: Liu
authors: Shao-Qiong
authors: SQ
authors: Liao
authors: Ming-Jie
authors: MJ
authors: Zhang
authors: Chang-Yue
authors: CY
authors: Gao
authors: Li-Li
authors: LL
authors: Zhang
mesh_terms: D000483:Alleles; D050197:Atherosclerosis / Q000235:genetics*; D016208:Databases, Factual; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015850:Interleukin-6
keywords: AAA; AS; Atherosclerosis; CAD; CHD; CI; CVDs; HWE; Hardy–Weinberg equilibrium; IL-6; IS; Interleukin-6; MI; MeSH; Medical Subject Heading; Meta-analysis; NOS; Newcastle-Ottawa Scale; OR; PAD; PAOD; PRISMA; Polymorphism; Preferred Reporting Items for Systematic Reviews and Meta-analyses; RAO; RAS; TIA; abdominal aortic aneurysm; atherosclerosis; cardiovascular diseases; confidence interval; coronary artery disease; coronary heart disease; interleukin-6; ischemic stroke; myocardial infarction; odds ratio; peripheral Arterial Disease; peripheral artery occlusive disease; renal artery stenosis; retinal artery occlusion; transient ischemic attack, CAS carotid artery stenosis