title: Organic electrochemical transistor array for recording transepithelial ion transport of human airway epithelial cells.
abstract: An organic electrochemical transistor array is integrated with human airway epithelial cells. This integration provides a novel method to couple transepithelial ion transport with electrical current. Activation and inhibition of transepithelial ion transport are readily detected with excellent time resolution. The organic electrochemical transistor array serves as a promising platform for physiological studies and drug testing.
authors: Bioengineering Graduate Program, Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
authors: Chunlei
authors: C
authors: Yao
authors: Changyan
authors: C
authors: Xie
authors: Peng
authors: P
authors: Lin
authors: Feng
authors: F
authors: Yan
authors: Pingbo
authors: P
authors: Huang
authors: I-Ming
authors: IM
authors: Hsing
mesh_terms: D002460:Cell Line; D055664:Electrochemical Techniques; D004566:Electrodes; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D007477:Ions / Q000737:chemistry / Q000378:metabolism; D009930:Organic Chemicals / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D007477:Ions; D009930:Organic Chemicals; D011137:Polystyrenes; D013876:Thiophenes; C533756:poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)
keywords: cell biosensors; cystic fibrosis transmembrane conductance regulators; ion channels; organic electrochemical transistors; transepithelial ion transport