title: Salience network resting-state activity: prediction of frontotemporal dementia progression.
abstract: OBJECTIVE
  Noninvasive measures of activity within intrinsic brain networks may be clinically relevant, providing a marker of neurodegenerative disease and predicting clinical behaviors.
  
  
  OBJECTIVE
  To correlate baseline resting-state measures within the salience network and changes in behavior among patients with frontotemporal dementia.
  
  
  METHODS
  Baseline resting-state functional magnetic resonance imaging data and longitudinal clinical measures were obtained from prospectively accrued patients during 8 weeks.
  
  
  METHODS
  Tertiary academic care center specializing in the assessment and management of patients with neurodegenerative disease.
  
  
  METHODS
  Fifteen patients with clinically diagnosed frontotemporal dementia (5 behavioral variant and 10 semantic dementia).
  
  
  METHODS
  Baseline resting-state functional magnetic resonance imaging data measured within regions of interest were regressed on serial behavioral measures from prospectively accrued patients with frontotemporal dementia to determine the ability of baseline resting-state activity to account for changes in behavior.
  
  
  RESULTS
  Low-frequency fluctuations in the left insula significantly predicted changes in Frontal Behavioral Inventory scores (standard β = 0.51, P = .049), accounting for 28% of the change variance. The trend was driven by changes in measures of apathy independent of dementia severity.
  
  
  CONCLUSIONS
  Baseline measures of salience network connectivity involving the left insula may predict behavioral changes in patients with frontotemporal dementia.
authors: Gregory S
authors: GS
authors: Day
authors: Norman A S
authors: NA
authors: Farb
authors: David F
authors: DF
authors: Tang-Wai
authors: Mario
authors: M
authors: Masellis
authors: Sandra E
authors: SE
authors: Black
authors: Morris
authors: M
authors: Freedman
authors: Bruce G
authors: BG
authors: Pollock
authors: Tiffany W
authors: TW
authors: Chow
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D012720:Severity of Illness Index
chemical_list: D010100:Oxygen