title: The rs1050450 C > T polymorphism of GPX1 is associated with the risk of bladder but not prostate cancer: evidence from a meta-analysis.
abstract: Glutathione peroxidase (GPX) is an endogenous antioxidant enzyme counteracting oxidative stress. Accumulating evidence has demonstrated that the GPX1 rs1050450 C > T polymorphism may modulate cancer risk, but the association of GPX1 rs1050450 polymorphism with bladder cancer (BC) and prostate cancer (PCa) is still inconclusive. This meta-analysis was designed to determine the exact association of GPX1 rs1050450 C > T polymorphism with the risk of bladder cancer and prostate cancer. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the association strength. Databases of PubMed, EMBASE, and China National Knowledge Infrastructure were searched to retrieve eligible studies. In total, ten eligible studies with 6,194 participants were included. By pooling all eligible studies, we found that carriers of the variant T allele were associated with a significantly increased risk of urinary tract cancer (T vs. C: OR = 1.459 and 95% CI, 1.086-1.962; CT/TT vs. CC: OR = 1.411 and 95 % CI, 1.053-1.891). In stratified analysis, we observed that the rs1050450 C > T polymorphism was significantly associated with an increased risk of BC (T vs. C: OR = 2.111 and 95% CI, 1.020-4.368; CT/TT vs. CC: OR = 1.876 and 95% CI, 1.011-3.480), while the association was not significant for PCa. Egger's test and Begg's test revealed no publication bias. The present meta-analysis provides evidence that the GPX1 rs1050450 C > T polymorphism leads to an increased risk of BC but not the risk of PCa.
authors: Department of Urology, Qianfoshan Hospital Affiliated to Shandong University, 283 Jingwu Rd, Huaiyin District, Jinan, 250012, China.
authors: Tongyi
authors: T
authors: Men
authors: Xiaoming
authors: X
authors: Zhang
authors: Jiwei
authors: J
authors: Yang
authors: Bin
authors: B
authors: Shen
authors: Xianduo
authors: X
authors: Li
authors: Dongdong
authors: D
authors: Chen
authors: Jianning
authors: J
authors: Wang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D017594:Publication Bias; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1
chemical_list: D005979:Glutathione Peroxidase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human
references: Minerva Urol Nefrol. 2011 Sep;63(3):183-90
references: 21993316
references: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1115-20
references: 17548672
references: Oncol Res. 2010;18(8):395-400
references: 20441054
references: Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1552-4
references: 21586620
references: BJU Int. 2011 Jan;107(1):126-34
references: 20477822
references: Hum Exp Toxicol. 2012 Jan;31(1):24-31
references: 21636625
references: Urol Int. 2011;87(2):159-64
references: 21625079
references: BJU Int. 2000 Jul;86 Suppl 1:111-22
references: 10961281
references: Cancer Res. 2003 Jun 15;63(12):3347-51
references: 12810669
references: J Nutr. 2011 Sep;141(9):1731-7
references: 21795425
references: Acc Chem Res. 2010 Nov 16;43(11):1408-19
references: 20690615
references: Ann Intern Med. 1997 Nov 1;127(9):820-6
references: 9382404
references: Acta Histochem. 2010 Jul;112(4):364-71
references: 19500819
references: Biol Trace Elem Res. 2004 Nov;101(2):97-106
references: 15557674
references: Int Urol Nephrol. 2009;41(1):63-70
references: 18563616
references: J Nutrigenet Nutrigenomics. 2012;5(6):339-51
references: 23363810
references: N Engl J Med. 2007 Dec 27;357(26):2696-705
references: 18160689
references: Carcinogenesis. 2004 Oct;25(10):1935-44
references: 15192016
references: Breast Cancer Res. 2001;3(5):323-7
references: 11597322
references: Cancer Lett. 2005 Nov 8;229(1):85-91
references: 15946795
references: Med Oncol. 2012 Sep;29(3):1928-34
references: 21904836
references: Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2958-68
references: 20852007
references: Prostate Cancer Prostatic Dis. 2002;5(3):189-92
references: 12496980
references: Cell Mol Life Sci. 2000 Dec;57(13-14):1825-35
references: 11215509
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: Environ Health Perspect. 1997 Jun;105 Suppl 4:875-82
references: 9255574
references: Carcinogenesis. 2010 Jun;31(6):1074-9
references: 20378690
references: J Urol. 2004 Aug;172(2):728-32
references: 15247771
references: BMC Cancer. 2008 Feb 25;8:60
references: 18298806
references: Prostate. 2013 May;73(7):734-42
references: 23143801
references: J Clin Epidemiol. 2001 Oct;54(10):1046-55
references: 11576817
references: Cancer Res. 2006 Jan 15;66(2):1225-33
references: 16424062