title: PSA testing without clinical indication for prostate cancer in relation to socio-demographic and clinical characteristics in the Danish Diet, Cancer and Health Study.
abstract: BACKGROUND
  Social differences in prostate cancer (PC) incidence and mortality might be related to testing for prostate-specific antigen (PSA). Although routine PSA screening is not recommended in Denmark, testing without clinical indication increased during the past decade. We evaluated associations between socio-demographic or clinical characteristics and PSA testing without clinical indication.
  
  
  METHODS
  In the Danish Diet, Cancer and Health Cohort, we identified 1051 men with PC diagnosed in 1993-2008. Diagnostic and clinical characteristics were obtained from medical records, and socio-demographic information was retrieved from administrative registers. We used general logistic regression analysis to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between socio-demographic or clinical characteristics and PSA testing without clinical indication. Cox regression analysis was used to examine associations with mortality.
  
  
  RESULTS
  PSA testing without clinical indication was less likely among patients > 67 years (OR 0.7; 0.5-1.0). Men who were, PSA tested without clinical indication, were more likely to have vocational training (OR 1.8; 1.1-2.9) or higher education (OR 1.5; 0.9-2.5) and less likely to have advanced disease (OR 0.6; 0.4-0.9). PSA testing without clinical indication more often preceded therapy with curative intent (OR 1.8; 1.1-2.9) and less often palliative treatment (OR 0.6; 0.3-1.0). Men who were PSA tested without clinical indication had non-significantly lower overall and PC-specific mortality [hazard ratios 0.8 (0.5-1.2) and 0.6 (0.3-1.1), respectively].
  
  
  CONCLUSIONS
  PSA testing without clinical indication was associated with higher educational level. PC detected by PSA testing with no clinical indication was more often localized and treated with curative intent.
authors: Danish Cancer Society Research Center , Copenhagen , Denmark.
authors: Randi V
authors: RV
authors: Karlsen
authors: Signe B
authors: SB
authors: Larsen
authors: Jane
authors: J
authors: Christensen
authors: Klaus
authors: K
authors: Brasso
authors: Søren
authors: S
authors: Friis
authors: Anne
authors: A
authors: Tjønneland
authors: Susanne Oksbjerg
authors: SO
authors: Dalton
mesh_terms: D000368:Aged; D003710:Demography; D003718:Denmark; D055088:Early Detection of Cancer / Q000706:statistics & numerical data / Q000639:trends*; D005247:Feeding Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D044469:Racial Groups; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate
chemical_list: D017430:Prostate-Specific Antigen