title: Polyketides from the littoral plant associated fungus Pseudallescheria boydii.
abstract: Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(-)-mevalonolactone (6), (R)-(-)-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1-9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher's method. The growth inhibitory activities of 1-9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI₅₀ values of 41.3 and 4.1 μM, respectively, in comparison with fluorouracil (GI₅₀ = 3.6 μM).
authors: School of Pharmacy, Taipei Medical University , Taipei, Taiwan 110.
authors: Ya-Chih
authors: YC
authors: Chang
authors: Tzu-Shing
authors: TS
authors: Deng
authors: Ka-Lai
authors: KL
authors: Pang
authors: Che-Jen
authors: CJ
authors: Hsiao
authors: Yi-Ying
authors: YY
authors: Chen
authors: Shye-Jye
authors: SJ
authors: Tang
authors: Tzong-Huei
authors: TH
authors: Lee
mesh_terms: D035722:Aizoaceae / Q000382:microbiology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011541:Pseudallescheria / Q000737:chemistry*; D021681:Scedosporium
chemical_list: D000970:Antineoplastic Agents; D061065:Polyketides; C584997:botryorhodine F; C584998:botryorhodine G; C584996:boydone A; C584999:boydone B; D005472:Fluorouracil