title: A contusion model of severe spinal cord injury in rats.
abstract: The translational potential of novel treatments should be investigated in severe spinal cord injury (SCI) contusion models. A detailed methodology is described to obtain a consistent model of severe SCI. Use of a stereotactic frame and computer controlled impactor allows for creation of reproducible injury. Hypothermia and urinary tract infection pose significant challenges in the post-operative period. Careful monitoring of animals with daily weight recording and bladder expression allows for early detection of post-operative complications. The functional results of this contusion model are equivalent to transection models. The contusion model can be utilized to evaluate the efficacy of both neuroprotective and neuroregenerative approaches.
authors: Department of Neuroscience, Division of Neurosurgery, Medical University of South Carolina, USA. vibhorkrishna@gmail.com
authors: Vibhor
authors: V
authors: Krishna
authors: Hampton
authors: H
authors: Andrews
authors: Xing
authors: X
authors: Jin
authors: Jin
authors: J
authors: Yu
authors: Abhay
authors: A
authors: Varma
authors: Xuejun
authors: X
authors: Wen
authors: Mark
authors: M
authors: Kindy
mesh_terms: D000818:Animals; D003288:Contusions / Q000473:pathology*; D004195:Disease Models, Animal; D051381:Rats; D013119:Spinal Cord Injuries / Q000473:pathology*
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