title: Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.
abstract: A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.
authors: Department of Neuroscience, College of Medicine, Korea University, Seoul 136-705, Republic of Korea.
authors: Chung
authors: C
authors: Ju
authors: Sumi
authors: S
authors: Song
authors: Sunyoung
authors: S
authors: Hwang
authors: Chorong
authors: C
authors: Kim
authors: Minkyoung
authors: M
authors: Kim
authors: Jail
authors: J
authors: Gu
authors: Yu-Kyoung
authors: YK
authors: Oh
authors: Kyeong
authors: K
authors: Lee
authors: Jinsun
authors: J
authors: Kwon
authors: Kiho
authors: K
authors: Lee
authors: Won-Ki
authors: WK
authors: Kim
authors: Yongseok
authors: Y
authors: Choi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000081008:Bicyclic Monoterpenes; D002478:Cells, Cultured; D004195:Disease Models, Animal; D055808:Drug Discovery; D007511:Ischemia / Q000188:drug therapy; D016202:N-Methylaspartate / Q000737:chemistry; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D000081008:Bicyclic Monoterpenes; D018696:Neuroprotective Agents; D013729:Terpenes; D016202:N-Methylaspartate; C052875:verbenone
keywords: Anti-excitotoxic activity; Anti-ischemic activity; Anti-oxidant activity; Cerebral ischemia; Verbenone