title: Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6- and IL-10-independent mechanisms.
abstract: Some parasitic helminths are known to protect their hosts from allergic and autoimmune disorders. Here, we tested the effects of a gastrointestinal nematode, Heligmosomoides polygyrus (Hp), on streptozotocin (STZ)-induced type 1 diabetes (T1D) in mice. Hp infection significantly suppressed hyperglycemia induced by multiple low-dose administration of STZ, but did not affect hyperglycemia induced by single high-dose administration of STZ. In the multiple low dose model, Hp infection prevented a decrease in pancreatic islet size. The augmentation of TNF-α and IL-1β expression in the pancreas was abrogated by Hp infection. The genetic absence of IL-10 or STAT6 did not abrogate the anti-hyperglycemic effect of Hp. Hp has a suppressive effect on immune mechanism-mediated experimental T1D via Th2 polarization-independent mechanisms.
authors: Department of Immunology and Parasitology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Electronic address: yosada@med.uoeh-u.ac.jp.
authors: Yoshio
authors: Y
authors: Osada
authors: Sohsuke
authors: S
authors: Yamada
authors: Atsunori
authors: A
authors: Nabeshima
authors: Yasunobu
authors: Y
authors: Yamagishi
authors: Kenji
authors: K
authors: Ishiwata
authors: Susumu
authors: S
authors: Nakae
authors: Katsuko
authors: K
authors: Sudo
authors: Tamotsu
authors: T
authors: Kanazawa
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology*; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics; D016753:Interleukin-10 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009351:Nematospiroides dubius / Q000276:immunology*; D050800:STAT6 Transcription Factor / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D012720:Severity of Illness Index; D013047:Specific Pathogen-Free Organisms; D017206:Strongylida Infections / Q000150:complications / Q000276:immunology*
chemical_list: D016207:Cytokines; D050800:STAT6 Transcription Factor; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: Cytokine; Diabetes; Heligmosomoides polygyrus; Helminth; Immunomodulation; Streptozotocin