title: A comparison of the predicted risk for cardiovascular disease between HIV-infected and uninfected persons in Korea.
abstract: BACKGROUND
  The introduction of highly active antiretroviral therapy (HAART) has extended the life expectancy of persons infected with the human immunodeficiency virus type 1 (HIV-1). However, cardiovascular disease (CVD) is currently an increasing concern for HIV-infected persons.
  
  
  METHODS
  We conducted a cross-sectional case-control study to evaluate and compare the 10-y cardiovascular risk of HIV-infected Koreans who had been receiving HAART for over 6 months and age- and sex-matched uninfected persons who visited a health promotion center, by calculating Framingham risk scores (FRS).
  
  
  RESULTS
  The average 10-y risk for cardiovascular events (FRS) was 7.07% (2-45) in the HIV group and 6.87% (1-37) in the control group (p = 0.77), corresponding to the very low risk group. Among HIV patients, the FRS was above 10% (low to moderate cardiovascular risk) in 19.9% of the patients, and above 20% (high risk) in 1.7% of the patients. In the healthy control group, the FRS was above 10% in 16.8% and above 20% in 2.7% (p = 0.57). The FRS was not significantly different for HIV-infected patients treated with protease inhibitor (PI)-based HAART and those treated with non-nucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (7.26 ± 6.3 and 6.81 ± 4.4, respectively, p = 0.69).
  
  
  CONCLUSIONS
  The predicted cardiovascular risk of HIV-infected Koreans on HAART by FRS equation was low and similar to that of age- and sex-matched healthy control persons. However, the possibility remains that actual cardiovascular events could be underestimated. The next step for predicting the cardiovascular risk is to calculate the Data Collection of Adverse Events of Anti-HIV Drugs (D:A:D) equation risks.
authors: From the Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine , Seoul , Republic of Korea.
authors: Sun Bean
authors: SB
authors: Kim
authors: Yong Chan
authors: YC
authors: Kim
authors: Min Hyung
authors: MH
authors: Kim
authors: Je Eun
authors: JE
authors: Song
authors: Dong Hyun
authors: DH
authors: Oh
authors: Jin Young
authors: JY
authors: Ahn
authors: Nam Su
authors: NS
authors: Ku
authors: Hye-Won
authors: HW
authors: Kim
authors: Su Jin
authors: SJ
authors: Jeong
authors: Sang Hoon
authors: SH
authors: Han
authors: Young Goo
authors: YG
authors: Song
authors: Jun Yong
authors: JY
authors: Choi
authors: June Myung
authors: JM
authors: Kim
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment