title: Relationship between HLA molecules and late restenosis after coronary stent placement.
abstract: OBJECTIVE
  The objective of this study is to confirm whether there is relation between the human leucocyte antigen (HLA) locus and restenosis after percutaneous coronary intervention (PCI) holds in our patient population and whether it can be useful as a prognostic factor.
  
  
  METHODS
  We examined the HLA phenotypes in 46 consecutive patients (39 men, 7 women, mean age of 57 ± 9 years) who had successful stent implantation in the coronary artery. Selective coronary arteriography was performed 6 months after coronary stenting to assess the presence of restenosis. The HLA phenotyping was performed for HLA-A,-B,-C antigens by Terasaki microlymphocytotoxicity technique and for HLA-DR alleles with PCR-SSP technique.
  
  
  RESULTS
  Restenosis(R+) was present in 12 (26.1%) patients (11 men, 1 woman, mean age of 57 ± 10 years). For HLA Class I antigens frequency of HLA-B62 and HLA-CW2 antigen was slightly higher in restenotic patients but did not reach statistical significance. For HLA-DR alleles restenotic patients had higher frequencies for HLA-DRB1(∗)01(R+ %25, R- %14.7), and HLA-DR11(R+ %41.7, R- %20.6), without reaching statistical significance and lower frequencies for DR7(R+ %0, R- %17.6) and D13(R+%8.3, R- %32.4) and HLA-DR53 (R+ %25, R- %35.3) without reaching statistical significance.
  
  
  CONCLUSIONS
  In conclusion, results show that there was no relationship between the development of restenosis and HLA-subtypes.
authors: Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, 34390 Istanbul.
authors: Hasan
authors: H
authors: Kudat
authors: Mustafa
authors: M
authors: Ozcan
authors: Tufan
authors: T
authors: Tükek
authors: Ahmet Bilge
authors: AB
authors: Sözen
authors: Vakur
authors: V
authors: Akkaya
authors: Fatma
authors: F
authors: Oguz
authors: Yalçın
authors: Y
authors: Seyhun
keywords: HLA; Restenosis; Stent implantation
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