title: The possible role of Mena protein and its splicing-derived variants in embryogenesis, carcinogenesis, and tumor invasion: a systematic review of the literature.
abstract: The Ena/VASP (enabled/vasodilator stimulated phosphoprotein) family includes the binding actin proteins such as mammalian Ena (Mena), VASP, and Ena-VASP-like. It is known that the perturbation of actin cycle could determine alteration in the mobility of cells and in consequence of organogenesis. Few recent studies have revealed that Mena protein could play a role in breast or pancreatic carcinogenesis. Based on our researches, we observed that the intensity of Mena expression increased from premalignant to malignant lesions in some organs such as large bowel, stomach, cervix, and salivary glands. These findings prove that Mena could be a marker of premalignant epithelial lesions. In premalignant lesions, it could be helpful to define more accurately the risk for malignant transformation. In malignant tumors, correlation of expression of its splice variants could indicate metastatic behavior. In conclusion, we consider that it is necessary to analyze the expression of Mena splice variants in a higher number of cases, in different epithelial lesions, and also in experimental studies to define its exact role in carcinogenesis and also its possible prognostic and predictive values.
authors: Department of Pathology, University of Medicine and Pharmacy of Targu-Mures, 38 Ghe Marinescu Street, 540193 Targu Mures, Romania. simonagurzu@yahoo.com
authors: Simona
authors: S
authors: Gurzu
authors: Diana
authors: D
authors: Ciortea
authors: Istvan
authors: I
authors: Ember
authors: Ioan
authors: I
authors: Jung
mesh_terms: D000199:Actins / Q000378:metabolism; D017398:Alternative Splicing / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics*; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D011485:Protein Binding; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
chemical_list: D000199:Actins; D004268:DNA-Binding Proteins; C092744:ENA-VASP proteins; C511939:Enah protein, human; D008840:Microfilament Proteins; D020033:Protein Isoforms
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