title: Health-related quality of life of HIV-infected intravenous drug users.
abstract: To investigate health-related quality of life in HIV-infected intravenous drug users registered but not engaged in HIV outpatient care (missing ≥2 outpatient appointments over 1 year or non-attendance for ≥6 months) we conducted a cross-sectional study to examine health-related quality of life of HIV-infected intravenous drug users registered for care at an inner city HIV unit. EQ-5D, SF-36, SF-6D, mood disorder, clinical and substance misuse data were collected. Mean scores and preference derived utility scores were calculated. Statistical relationships between health-related quality of life and other variables were explored using univariate and multivariate analysis. Fifty-five patients were recruited, 64% were males. The mean anxiety value was 11.44 (anxious) and mean depression score was 9.3 (borderline depressed). The mean EQ-5D utility was 0.45 (95% CI 0.35, 0.55) and mean SF-6D utility was 0.52 (95% CI 0.48, 0.55). There was no statistical relationship between HIV indices, substance misuse and EQ-5D and SF-6D utility. Anxiety and depression were significantly correlated with EQ-5D and SF-6D utility values on univariate and multivariate analysis. Health-related quality of life was reduced in this HIV-infected intravenous drug user population. Whilst hepatitis C co-infection and substance misuse did not affect health-related quality of life, anxiety and depression had a significant impact on it.
authors: The GUIDE clinic (Department of Genito-Urinary Medicine & Infectious Diseases), St James's Hospital, Dublin, Ireland.
authors: S
authors: S
authors: Surah
authors: R
authors: R
authors: Adams
authors: L
authors: L
authors: Townsend
authors: I
authors: I
authors: Reynolds
authors: J C
authors: JC
authors: Kinahan
authors: S
authors: S
authors: Keating
authors: F
authors: F
authors: Mulcahy
authors: E
authors: E
authors: Keenan
authors: M
authors: M
authors: Barry
authors: F
authors: F
authors: Lyons
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D055030:Drug Users / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012959:Socioeconomic Factors; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000523:psychology*; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology*; D011795:Surveys and Questionnaires
keywords: AIDS; HIV; antiretroviral therapy; anxiety; depression; health-related quality of life; injecting drug use; viral disease