title: MiR-215 modulates gastric cancer cell proliferation by targeting RB1.
abstract: Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.
authors: The Center for Diseases Modeling, and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors: Yujie
authors: Y
authors: Deng
authors: Zhenxia
authors: Z
authors: Huang
authors: Yanjun
authors: Y
authors: Xu
authors: Juan
authors: J
authors: Jin
authors: Wei
authors: W
authors: Zhuo
authors: Cheng
authors: C
authors: Zhang
authors: Xuting
authors: X
authors: Zhang
authors: Minhong
authors: M
authors: Shen
authors: Xiaoyi
authors: X
authors: Yan
authors: Liangjing
authors: L
authors: Wang
authors: Xiaojia
authors: X
authors: Wang
authors: Yibin
authors: Y
authors: Kang
authors: Jianmin
authors: J
authors: Si
authors: Tianhua
authors: T
authors: Zhou
mesh_terms: D020413:3' Untranslated Regions; D000368:Aged; D019540:Area Under Curve; D001483:Base Sequence; D001665:Binding Sites; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D012372:ROC Curve; D016160:Retinoblastoma Protein / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome; D015854:Up-Regulation
chemical_list: D020413:3' Untranslated Regions; D014408:Biomarkers, Tumor; C553667:MIRN215 microRNA, human; D035683:MicroRNAs; D016160:Retinoblastoma Protein
keywords: Gastric cancer; MiR-215; Proliferation; Retinoblastoma