title: [Synthetic transformations of higher terpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with a piperidine or pyrrolidine nitroxide moiety].
abstract: The reaction of betulonic acid chloride with 4-amino-2,2,6,6-tetramethylpeperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl gave corresponding triterpenoid amides. It was found that new derivatives exhibit cytotoxic activity against tumor cells CEM-13, U-937, MT-4. CCID50 value for most activity compound--N-[3-oxolup-20(29)-en-30-yl]-(2,2,6,6-tetramethylpiperidine-4-yl)-1-oxyl--was 5.7-33.1 microM.
authors: A N
authors: AN
authors: Antimonova
authors: N I
authors: NI
authors: Petrenko
authors: E E
authors: EE
authors: Shults
authors: Iu F
authors: IuF
authors: Polienko
authors: M M
authors: MM
authors: Shakirov
authors: I G
authors: IG
authors: Irtegova
authors: M A
authors: MA
authors: Pokrovskiĭ
authors: K M
authors: KM
authors: Sherman
authors: I A
authors: IA
authors: Grigor'ev
authors: A G
authors: AG
authors: Pokrovskiĭ
authors: G A
authors: GA
authors: Tolstikov
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013113:Spin Labels; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D009828:Oleanolic Acid; D013113:Spin Labels; D013729:Terpenes; C118308:betulonic acid; D000094062:Betulinic Acid