title: Depression in older patients with advanced colorectal cancer is closely connected with immunosuppressive acidic protein.
abstract: Colorectal cancer (CRC) is one of the most common tumors. CRC patients are susceptible to suffering from depression. Whether the immune system of CRC patients with depression is impaired or stimulated is controversial. Possible reasons for this conflict are the involvement of confounding factors, such as the age of the patient, the stage of the CRC and the types of treatment in previous studies. To demonstrate clearly the relationship between depression and the immune system in the context of CRC, the present study included only older patients with advanced CRC who received only chemotherapy, and the study adopted immunosuppressive acidic protein (IAP) as an immune parameter for the first time. A total of 56 older patients with advanced CRC completed the Zung Self-Rating Depression Scale (SDS) and were divided into two groups according to SDS scores. The patients exhibiting depression were treated with fluoxetine until their symptoms remitted. The serum levels of IAP and the percentages of CD3-positive (CD3+), CD4+, CD8+ T lymphocytes and CD56+ natural killer (NK) cells and Neutrophil-lymphocyte ratio (NLR) were calculated at the time of enrollment and once the symptoms remitted. Correlation analyses revealed that the SDS score was positively associated with serum IAP levels but negatively associated with CD3 and CD4 levels. Among the depressed and non-depressed patients, serum IAP levels and the percentages of CD3 and CD4 cells were dramatically different. After the depression symptoms were treated, the IAP levels dramatically decreased, while the levels of CD3, CD4, CD8 and CD56 were unchanged. All of above suggested that IAP was closely correlated with depression and might be a relatively objective parameter for predicting depression.
authors: Myeloma and Lymphoma Center, Department of Hematology, Chang Zheng Hospital, Second Military Medical University, Shanghai, 200003, China.
authors: Rong
authors: R
authors: Li
authors: Jie
authors: J
authors: Yang
authors: Jihua
authors: J
authors: Yang
authors: Weijun
authors: W
authors: Fu
authors: Hua
authors: H
authors: Jiang
authors: Juan
authors: J
authors: Du
authors: Chunyang
authors: C
authors: Zhang
authors: Hao
authors: H
authors: Xi
authors: Jian
authors: J
authors: Hou
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000523:psychology*; D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D015703:Antigens, CD / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000523:psychology*; D003863:Depression / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D009504:Neutrophils; D057566:Self Report; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015703:Antigens, CD; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein; D005473:Fluoxetine
references: Brain Behav Immun. 2007 May;21(4):374-83
references: 17360153
references: Psychosom Med. 2011 Nov-Dec;73(9):724-30
references: 22021459
references: Jpn J Cancer Res. 1994 Jan;85(1):93-100
references: 8106294
references: Am J Med. 1998 Sep 28;105(3A):35S-42S
references: 9790480
references: J Surg Oncol. 2008 Apr 1;97(5):404-8
references: 18181167
references: Aging Ment Health. 2013;17(4):470-8
references: 23215855
references: Cancer. 1996 Jun 1;77(11):2206-12
references: 8635085
references: Int J Colorectal Dis. 2012 Oct;27(10):1347-57
references: 22460305
references: Cancer Res. 1981 Aug;41(8):3244-52
references: 6166371
references: Clin Psychol Psychother. 2014 Sep-Oct;21(5):411-9
references: 23716367
references: Nurs Res Pract. 2010;2010:693961
references: 21994813
references: Br J Cancer. 2011 Apr 12;104(8):1288-95
references: 21448173
references: Int J Clin Oncol. 2005 Dec;10(6):411-7
references: 16369745
references: Pol J Pathol. 2012 Dec;63(4):221-7
references: 23359190
references: World J Gastroenterol. 2005 Apr 21;11(15):2313-8
references: 15818744
references: Anticancer Res. 2010 Mar;30(3):993-9
references: 20393026
references: Best Pract Res Clin Gastroenterol. 2009;23(6):889-907
references: 19942166
references: Int J Cancer. 2012 Oct 1;131(7):1649-58
references: 21607946
references: Tumour Biol. 2013 Oct;34(5):2809-15
references: 23681801
references: Dan Med J. 2012 Apr;59(4):B4428
references: 22459726
references: Biol Psychiatry. 2009 May 1;65(9):732-41
references: 19150053
references: Am J Psychiatry. 2002 Oct;159(10):1752-9
references: 12359683
references: Surgery. 2012 Sep;152(3):403-13
references: 22938900
references: Psychiatr Serv. 2003 Mar;54(3):297-9
references: 12610234
references: Surgeon. 2012 Oct;10(5):303
references: 22673586
references: Brain Behav Immun. 2011 Feb;25(2):221-9
references: 20955778
references: Surg Today. 1992;22(6):530-6
references: 1472793
references: Trends Immunol. 2006 Jan;27(1):24-31
references: 16316783
references: Eur J Pharmacol. 2011 Jun 1;659(2-3):265-72
references: 21497159
references: Oncology. 2012;82(5):261-8
references: 22538399
references: Br J Cancer. 2013 Jul 23;109(2):401-7
references: 23820256
references: Biomarkers. 2012 May;17(3):216-22
references: 22424597
references: Postgrad Med J. 2000 Sep;76(899):555-8
references: 10964119
references: Genes Immun. 2012 Jan;13(1):1-13
references: 22048454
references: J Appl Biobehav Res. 2013 Mar 1;18(1):37-57
references: 23526866
references: Metab Brain Dis. 2012 Mar;27(1):91-100
references: 22109853
references: Support Care Cancer. 2010 Apr;18(4):417-21
references: 19554353
references: Int J Colorectal Dis. 2011 Oct;26(10):1299-307
references: 21562744
references: Eur J Oncol Nurs. 2012 Jul;16(3):227-32
references: 21783416
references: Dis Esophagus. 2008;21(3):214-9
references: 18430101