title: [Synthesis, structure and farmacologycal activity of (7R,8S)-epoxy-(13R,17R)-trioxolaneabietic acid].
abstract: The synthesis and X-ray diffraction established the structure of (7R,8S)-(see text for symbol)-(13R,17R)-trioxolaneabietic acid. Predicted by the computer system PASS antineoplastic activity and the ability to induce apoptosis, a mechanism of cell death, is correlated with experimentally shown cytotoxic activity against malignant cell line MeWo. Results of tests on animals have shown that abietic acid and its 9R,11S-epoxy-12R,15R-trioxolane derivative have anti-inflammatory and antiulcer activity in the absence of adverse effects on animal organisms.
authors: O B
authors: OB
authors: Kazakova
authors: I E
authors: IE
authors: Smirnova
authors: Kh
authors: Kh
authors: Do Tkhi Tkhu
authors: Tkhankh Tra Nguen
authors: G N
authors: GN
authors: Apryshko
authors: O S
authors: OS
authors: Zhukova
authors: N I
authors: NI
authors: Medvedeva
authors: T I
authors: TI
authors: Nazyrov
authors: E V
authors: EV
authors: Tret'iakova
authors: I V
authors: IV
authors: Chudov
authors: A F
authors: AF
authors: Ismagilova
authors: K Iu
authors: KIu
authors: Suponitskiĭ
authors: D V
authors: DV
authors: Kazakov
authors: F E
authors: FE
authors: Safarov
authors: G A
authors: GA
authors: Tolstikov
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects; D005557:Formaldehyde / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D051381:Rats; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D014961:X-Ray Diffraction
chemical_list: D045784:Abietanes; D005557:Formaldehyde; D019342:Acetic Acid; C023710:abietic acid