title: Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.
abstract: Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt's bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4-8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt's bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt's bat.
authors: 1] Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, South Korea [3].
authors: Inge
authors: I
authors: Seim
authors: Xiaodong
authors: X
authors: Fang
authors: Zhiqiang
authors: Z
authors: Xiong
authors: Alexey V
authors: AV
authors: Lobanov
authors: Zhiyong
authors: Z
authors: Huang
authors: Siming
authors: S
authors: Ma
authors: Yue
authors: Y
authors: Feng
authors: Anton A
authors: AA
authors: Turanov
authors: Yabing
authors: Y
authors: Zhu
authors: Tobias L
authors: TL
authors: Lenz
authors: Maxim V
authors: MV
authors: Gerashchenko
authors: Dingding
authors: D
authors: Fan
authors: Sun
authors: S
authors: Hee Yim
authors: Xiaoming
authors: X
authors: Yao
authors: Daniel
authors: D
authors: Jordan
authors: Yingqi
authors: Y
authors: Xiong
authors: Yong
authors: Y
authors: Ma
authors: Andrey N
authors: AN
authors: Lyapunov
authors: Guanxing
authors: G
authors: Chen
authors: Oksana I
authors: OI
authors: Kulakova
authors: Yudong
authors: Y
authors: Sun
authors: Sang-Goo
authors: SG
authors: Lee
authors: Roderick T
authors: RT
authors: Bronson
authors: Alexey A
authors: AA
authors: Moskalev
authors: Shamil R
authors: SR
authors: Sunyaev
authors: Guojie
authors: G
authors: Zhang
authors: Anders
authors: A
authors: Krogh
authors: Jun
authors: J
authors: Wang
authors: Vadim N
authors: VN
authors: Gladyshev
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001835:Body Weight / Q000502:physiology; D002685:Chiroptera / Q000235:genetics*; D004455:Echolocation / Q000502:physiology; D016678:Genome / Q000235:genetics*; D006605:Hibernation / Q000235:genetics / Q000502:physiology; D008136:Longevity / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D011986:Receptors, Somatotropin / Q000235:genetics*; D012098:Reproduction / Q000235:genetics / Q000502:physiology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D059467:Transcriptome / Q000235:genetics
chemical_list: D011986:Receptors, Somatotropin; D017526:Receptor, IGF Type 1
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