title: Mechanistic insights into extracorporeal photochemotherapy: efficient induction of monocyte-to-dendritic cell maturation.
abstract: Extracorporeal photochemotherapy (ECP) is a widely used immunotherapy for cutaneous T cell lymphoma, as well as immunomodulation of graft-versus-host disease (GVHD) and transplanted organ rejection. ECP's mechanism encompasses large-scale physiologic platelet induction of dendritic cells (DCs). The normal bidirectional immunologic talents of DCs likely contribute heavily to ECP's capacity to immunize against tumor antigens, while also suppressing transplant immunopathology. Our understanding of how ECP physiologically induces monocyte-to-DC maturation can enhance the treatment's potency, potentially broaden its use to other cancers and autoimmune disorders and tailor its application to individual patients' diseases. ECP's next decade is filled with promise.
authors: Aaron and Marguerite Lerner Professor and Chairman, Department of Dermatology, Yale University School of Medicine, USA. Electronic address: redelson@yale.edu.
authors: Richard L
authors: RL
authors: Edelson
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007114:Immunization / Q000379:methods; D056747:Immunomodulation; D009000:Monocytes / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy; D016377:Organ Transplantation; D017893:Photopheresis / Q000379:methods*; D014181:Transplantation Immunology
chemical_list: D000951:Antigens, Neoplasm
keywords: Antigen-presenting cells; Cancer; Dendritic cells; Photopheresis; Tolerance
references: Lancet. 1977 Jul 30;2(8031):249-50
references: 69857
references: Nat Rev Cancer. 2004 May;4(5):401-11
references: 15122211
references: Blood. 2010 Dec 2;116(23):4838-47
references: 20720185
references: Int J Cancer. 1998 May 4;76(3):304-11
references: 9579563
references: J Immunol. 2008 Nov 1;181(9):5956-62
references: 18941184
references: Transfusion. 2013 Oct;53(10):2340-52
references: 23305044
references: N Engl J Med. 1998 Dec 10;339(24):1744-51
references: 9845709
references: Biol Blood Marrow Transplant. 2011 Dec;17(12):1775-82
references: 21621629
references: J Am Acad Dermatol. 1992 Sep;27(3):427-33
references: 1401279
references: Leuk Lymphoma. 2006 Aug;47(8):1495-503
references: 16966259
references: N Engl J Med. 1974 Aug 8;291(6):293-4
references: 4276213
references: Transplantation. 1991 Jun;51(6):1283-9
references: 1828639
references: Nucleic Acids Res. 1985 Apr 11;13(7):2533-44
references: 4000963
references: N Engl J Med. 1987 Feb 5;316(6):297-303
references: 3543674
references: Proc Natl Acad Sci U S A. 1987 Jan;84(1):246-50
references: 3491992
references: Transfus Apher Sci. 2010 Oct;43(2):211-5
references: 20926344
references: Ann Intern Med. 1975 Oct;83(4):534-52
references: 126656
references: Transfus Sci. 1994 Dec;15(4):443-54
references: 10155563
references: Nature. 1998 Mar 5;392(6671):86-9
references: 9510252
references: Ann N Y Acad Sci. 1991 Dec 30;636:113-23
references: 1793203