title: Mechanisms of apoptotic phosphatidylserine exposure.
abstract: It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.
authors: 1] INSERM, U848, F-94805 Villejuif, France [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.
authors: Guillermo
authors: G
authors: Mariño
authors: Guido
authors: G
authors: Kroemer
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D049294:Phospholipid Transfer Proteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*
chemical_list: D049294:Phospholipid Transfer Proteins; D010743:Phospholipids; D002118:Calcium
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