title: Bombarding cancer: biolistic delivery of therapeutics using porous Si carriers.
abstract: A new paradigm for an effective delivery of therapeutics into cancer cells is presented. Degradable porous silicon carriers, which are tailored to carry and release a model anti-cancer drug, are biolistically bombarded into in-vitro cancerous targets. We demonstrate the ability to launch these highly porous microparticles by a pneumatic capillary gene gun, which is conventionally used to deliver cargos by heavy metal carriers. By optimizing the gun parameters e.g., the accelerating gas pressure, we have successfully delivered the porous carriers, to reach deep targets and to cross a skin barrier in a highly spatial resolution. Our study reveals significant cytotoxicity towards the target human breast carcinoma cells following the delivery of drug-loaded carriers, while administrating empty particles results in no effect on cell viability. The unique combination of biolistics with the temporal control of payload release from porous carriers presents a powerful and non-conventional platform for designing new therapeutic strategies.
authors: 1] Faculty of Engineering, Bar-Ilan University, Ramat-Gan 5290002, Israel [2] Bar-Ilan Institute of Nanotechnologies and Advanced Materials, Ramat-Gan, 52900, Israel [3].
authors: Neta
authors: N
authors: Zilony
authors: Adi
authors: A
authors: Tzur-Balter
authors: Ester
authors: E
authors: Segal
authors: Orit
authors: O
authors: Shefi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D019470:Biolistics / Q000379:methods*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000737:chemistry; D016062:Porosity; D012825:Silicon / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008942:Mitoxantrone; D012825:Silicon
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