title: Ginsenoside Rh2 improves learning and memory in mice.
abstract: A wide range of plant foods and dietary supplements are able to modify the functioning of the central nervous system. In the present study, we observed that oral administration of ginsenoside Rh2 (10 mg/mL) for 3 weeks significantly improved spatial learning and memory. Spatial memory and learning was evaluated in mice by hippocampus-dependent tasks (Morris water maze test) and immunohistochemical marker of cell genesis bromodeoxyuridine. Ginsenoside Rh2 treatment (30 days) promoted cell survival and genesis. Further, ginsenoside Rh2 treatment in enriched condition had no significant effects on cell survival compared with standard condition exposure. These results revealed that ginsenoside Rh2-mediated spatial learning and memory improvement was associated with cell genesis and survival and may be parallel to the mechanism of environmental enrichment. Therefore, ginsenoside Rh2 may have efficacy as a dietary supplement for spatial learning and memory improvement.
authors: Department of Food Science and Technology, College of Agriculture and Biotechnology, Chungnam National University, Daejon, Korea.
authors: Jingang
authors: J
authors: Hou
authors: Jianjie
authors: J
authors: Xue
authors: Mira
authors: M
authors: Lee
authors: Lei
authors: L
authors: Liu
authors: Dongliang
authors: D
authors: Zhang
authors: Mengqi
authors: M
authors: Sun
authors: Yinan
authors: Y
authors: Zheng
authors: Changkeun
authors: C
authors: Sung
mesh_terms: D000818:Animals; D036145:Ginsenosides / Q000008:administration & dosage*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D036145:Ginsenosides; D010936:Plant Extracts; C055305:ginsenoside Rh2
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