title: Impact of a manualized multifocal perinatal home-visiting program using psychologists on postnatal depression: the CAPEDP randomized controlled trial.
abstract: BACKGROUND
  Postnatal maternal depression (PND) is a significant risk factor for infant mental health. Although often targeted alongside other factors in perinatal home-visiting programs with vulnerable families, little impact on PND has been observed.
  
  
  OBJECTIVE
  This study evaluates the impact on PND symptomatology of a multifocal perinatal home-visiting intervention using psychologists in a sample of women presenting risk factors associated with infant mental health difficulties.
  
  
  METHODS
  440 primiparous women were recruited at their seventh month of pregnancy. All were future first-time mothers, under 26, with at least one of three additional psychosocial risk factors: low educational level, low income, or planning to raise the child without the father. The intervention consisted of intensive multifocal home visits through to the child's second birthday. The control group received care as usual. PND symptomatology was assessed at baseline and three months after birth using the Edinburgh Postnatal Depression Scale (EPDS).
  
  
  RESULTS
  At three months postpartum, mean (SD) EPDS scores were 9.4 (5.4) for the control group and 8.6 (5.4) for the intervention group (p = 0.18). The difference between the mean EPDS scores was 0.85 (95% CI: 0.35; 1.34). The intervention group had significantly lower EPDS scores than controls in certain subgroups: women with few depressive symptoms at inclusion (EPDS <8): difference = 1.66 (95%CI: 0.17; 3.15), p = 0.05, adjusted for baseline EPDS score), women who were planning to raise the child with the child's father: difference = 1.45 (95%CI: 0.27; 2.62), p = 0.04 (adjusted); women with a higher educational level: difference = 1.59 (95%CI: 0.50; 2.68) p = 0.05 (adjusted).
  
  
  CONCLUSIONS
  CAPEDP failed to demonstrate an overall impact on PND. However, post-hoc analysis reveals the intervention was effective in terms of primary prevention and in subgroups of women without certain risk factors. Effective overall reduction of PND symptomatology for young, first-time mothers presenting additional psychosocial risk factors may require more tailored interventions.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00392847 Promoting Parental Skills and Enhancing Attachment in Early Childhood (CAPEDP).
authors: Unité de Périnatalité, Centre Hospitalier Sainte-Anne, Paris, France. romain.dugravier@gmail.com
authors: Romain
authors: R
authors: Dugravier
authors: Florence
authors: F
authors: Tubach
authors: Thomas
authors: T
authors: Saias
authors: Nicole
authors: N
authors: Guedeney
authors: Blandine
authors: B
authors: Pasquet
authors: Diane
authors: D
authors: Purper-Ouakil
authors: Susana
authors: S
authors: Tereno
authors: Bertrand
authors: B
authors: Welniarz
authors: Joana
authors: J
authors: Matos
authors: Antoine
authors: A
authors: Guedeney
authors: Tim
authors: T
authors: Greacen
mesh_terms: D000328:Adult; D002675:Child, Preschool; D019052:Depression, Postpartum / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D004522:Educational Status; D005260:Female; D006792:House Calls / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008603:Mental Health / Q000706:statistics & numerical data; D009034:Mother-Child Relations / Q000523:psychology; D011181:Postnatal Care; D011203:Poverty; D011247:Pregnancy; D011613:Psychotherapy; D012307:Risk Factors; D015406:Single Parent
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