title: Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease.
abstract: Advanced chronic kidney disease (CKD) results in a constellation of dysregulation of lipid metabolism, oxidative stress, and inflammation which are causally interconnected and participate in a vicious cycle. The CKD-associated lipid disorders are marked by impaired clearance of very low density lipoprotein and chylomicrons, hypertriglyceridemia, formation of small dense low-density lipoprotein (LDL), oxidative modification of LDL, intermediate density lipoprotein and chylomicron remnants, and high-density lipoprotein deficiency and dysfunction. This review provides a brief overview of the role of CKD-induced lipid disorders in the pathogenesis of oxidative stress, inflammation, cardiovascular disease, impaired exercise capacity, cachexia and wasting syndrome.
authors: Division of Nephrology and Hypertension, University of California Irvine Medical Center, Suite 400, City Tower, 101 City Drive, Orange, CA, 92868, USA, ndvaziri@uci.edu.
authors: Nosratola D
authors: ND
authors: Vaziri
mesh_terms: D050197:Atherosclerosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D050171:Dyslipidemias / Q000150:complications / Q000503:physiopathology*; D004734:Energy Metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000209:etiology; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D018384:Oxidative Stress; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology; D019282:Wasting Syndrome / Q000209:etiology
chemical_list: D008075:Lipoproteins, HDL
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