title: The antiinflammatory mechanism of Igongsan in mouse peritoneal macrophages via suppression of NF-κB/Caspase-1 activation.
abstract: Igongsan (IGS), which is an herbal prescription composed of five different herbs, Ginseng Radix (root of Panax ginseng, Araliaceae), Atractylodis Rhizoma Alba (rhizome of Atractylodes Macrocephala, Compositae), Poria Sclerotium (sclerotium of Poria cocos, Polyporaceae), Glycyrrhizae Radix et Rhizoma (root and rhizome of Glycyrrhiza uralensis, Leguminosae), and Citri Unshius Pericarpium (Peel of Citrus unshiu, Rutaceae), has been traditionally used in Korea to treat a variety of inflammatory diseases. In this study, we investigated to elucidate the mechanism responsible for IGS's antiinflammatory effect in mouse peritoneal macrophages. The findings demonstrate that IGS inhibited the production of inflammatory cytokine and prostaglandins E2 . IGS inhibited the enhanced levels of cyclooxygenase-2 and inducible NO synthase caused by lipopolysaccharide (LPS). Additionally, it was shown that the antiinflammatory effect of IGS is through regulating the activation of nuclear factor-kappa B and caspase-1 in LPS-stimulated mouse peritoneal macrophages. These results provide novel insights into the pharmacological actions of IGS as a potential candidate for development of new drugs to treat inflammatory diseases.
  
  
  CONCLUSIONS
  These results provide novel insights into the pharmacological actions of IGS as a potential candidate for development of new drugs to treat inflammatory diseases.
authors: Department of Cosmeceutical Science, Daegu Hanny University, Yugok-dong, Kyungsan, 712-715, Korea.
authors: Su-Jin
authors: SJ
authors: Kim
authors: Hyun-Ji
authors: HJ
authors: Shin
authors: Byung-Joo
authors: BJ
authors: Lee
authors: Dae-Seung
authors: DS
authors: Kim
authors: Jong Hyun
authors: JH
authors: Lee
authors: Mi-Young
authors: MY
authors: Jeong
authors: Hye-Lin
authors: HL
authors: Kim
authors: Jinbong
authors: J
authors: Park
authors: Hara
authors: H
authors: Lim
authors: Sung-Hoon
authors: SH
authors: Kim
authors: Seung-Heon
authors: SH
authors: Hong
authors: Min-Woo
authors: MW
authors: Hwang
authors: Jae-Young
authors: JY
authors: Um
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D020170:Caspase 1 / Q000378:metabolism*; D002478:Cells, Cultured; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D008070:Lipopolysaccharides; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D055670:Medicine, Korean Traditional; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D008070:Lipopolysaccharides; D016328:NF-kappa B; D028321:Plant Preparations; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D020170:Caspase 1; D015232:Dinoprostone
keywords: caspase-1; igongsan; inflammation; macrophage; nuclear factor-kappa B