title: Reactive oxygen species, ageing and the hormesis police.
abstract: For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association with increased reactive oxygen species (ROS). The beneficial role of ROS in lifespan extension is consistent with the essential role of these molecules in cell signalling. However, the identity of specific forms of ROS that promote longevity remains unclear. In this article, we argue that in several model systems, hydrogen peroxide plays a crucial role in the induction of hormesis.
authors: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors: Paula
authors: P
authors: Ludovico
authors: William C
authors: WC
authors: Burhans
mesh_terms: D000818:Animals; D002470:Cell Survival; D059165:Hormesis; D006801:Humans; D008136:Longevity; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D017382:Reactive Oxygen Species
keywords: ROS signalling; ageing; caloric restriction; hormesis; longevity; oxidative damage
references: Trends Cell Biol. 2011 Oct;21(10):569-76
references: 21824781
references: J Biol Chem. 2003 Feb 28;278(9):6824-30
references: 12475988
references: Cell Cycle. 2013 Apr 15;12(8):1189-200
references: 23518504
references: Nature. 2002 Jul 18;418(6895):344-8
references: 12124627
references: J Biol Chem. 1998 Aug 28;273(35):22480-9
references: 9712873
references: Free Radic Biol Med. 2011 Jul 15;51(2):327-36
references: 21619928
references: J Gerontol A Biol Sci Med Sci. 2002 Mar;57(3):B109-14
references: 11867647
references: Cell Metab. 2007 Oct;6(4):280-93
references: 17908557
references: Cell Metab. 2011 Jun 8;13(6):668-78
references: 21641548
references: Mol Biol Cell. 2000 Dec;11(12):4241-57
references: 11102521
references: Kidney Int. 1994 Aug;46(2):405-13
references: 7967352
references: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6564-9
references: 15087496
references: EMBO J. 2000 Oct 2;19(19):5157-66
references: 11013218
references: Cell. 2002 Nov 15;111(4):471-81
references: 12437921
references: J Cell Biochem. 2004 Oct 15;93(3):588-97
references: 15378602
references: Antioxid Redox Signal. 2013 Oct 20;19(12):1362-72
references: 22901002
references: Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15123-8
references: 20696905
references: Trends Cell Biol. 2013 Mar;23(3):129-34
references: 23117019
references: Nature. 2012 Oct 18;490(7420):355-60
references: 23023126
references: Cell Cycle. 2012 Aug 15;11(16):3087-96
references: 22871733
references: Cell Metab. 2012 Apr 4;15(4):451-65
references: 22482728
references: Mech Ageing Dev. 2002 Nov;123(12):1579-87
references: 12470895
references: Aging Cell. 2005 Feb;4(1):41-52
references: 15659212
references: Free Radic Res. 2006 Dec;40(12):1244-9
references: 17090413
references: PLoS Biol. 2007 May;5(5):e110
references: 17472436
references: Biochim Biophys Acta. 2009 Oct;1790(10):1005-14
references: 19524016
references: Cell Metab. 2012 Sep 5;16(3):322-35
references: 22921415
references: PLoS Biol. 2010 Dec 07;8(12):e1000556
references: 21151885
references: PLoS Genet. 2008 Jan;4(1):e13
references: 18225956
references: Nucleic Acids Res. 2007;35(22):7505-13
references: 17986462
references: Cell Mol Life Sci. 2010 Jan;67(1):1-8
references: 19730800
references: Exp Suppl. 2012;101:551-64
references: 22945582
references: J Cell Biol. 2004 Sep 27;166(7):1055-67
references: 15452146
references: EXS. 1996;77:XI-XII
references: 8856965
references: PLoS One. 2007 Aug 15;2(8):e748
references: 17710147
references: Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2729-34
references: 21282621
references: Aging (Albany NY). 2010 Oct;2(10):709-26
references: 21076178
references: Aging Cell. 2008 Jun;7(3):405-17
references: 18331617
references: Cell. 2002 Nov 27;111(5):607-10
references: 12464172
references: Aging (Albany NY). 2011 Sep;3(9):821-8
references: 21931183