title: Development of a second generation palladium-catalyzed cycloalkenylation and its application to bioactive natural product synthesis.
abstract: A novel palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins is described. This protocol was devised to solve one of the drawbacks of the original palladium-catalyzed cycloalkenylation that we developed. We call this new procedure the 'second generation palladium-catalyzed cycloalkenylation'. This protocol has been applied to the total syntheses of cis-195A, trans-195A, boonein, scholareins A, C, D, and alpha-skytanthine.
authors: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. toyota@c.s.osakafu-u.ac.jp
authors: Masahiro
authors: M
authors: Toyota
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D001688:Biological Products; D010165:Palladium