title: Extranodal nasal NK/T-cell lymphoma: a rare oral presentation and FASN, CD44 and GLUT-1 expression.
abstract: Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with Epstein-Barr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results.
authors: João de Barros Barreto University Hospital, Federal University of Pará, Belém, PA, Brazil.
authors: Hélder Antônio Rebelo
authors: HA
authors: Pontes
authors: Flávia Sirotheau Corrêa
authors: FS
authors: Pontes
authors: Brunno Santos de Freitas
authors: BS
authors: Silva
authors: Felipe Paiva
authors: FP
authors: Fonseca
authors: Bruno Augusto Benevenuto de
authors: BA
authors: Andrade
authors: Victor Hugo Toral
authors: VH
authors: Rizo
authors: Mário José
authors: MJ
authors: Romañach
authors: Jorge Esquiche
authors: JE
authors: León
authors: Oslei Paes de
authors: OP
authors: Almeida
mesh_terms: D000328:Adult; D003951:Diagnostic Errors; D017809:Fatal Outcome; D054890:Fatty Acid Synthase, Type I / Q000032:analysis*; D005260:Female; D005887:Gingival Neoplasms / Q000175:diagnosis*; D005892:Gingivitis, Necrotizing Ulcerative / Q000175:diagnosis; D051272:Glucose Transporter Type 1 / Q000032:analysis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis*; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis*; D009918:Orbital Neoplasms / Q000175:diagnosis*
chemical_list: C497483:CD44 protein, human; D051272:Glucose Transporter Type 1; D018960:Hyaluronan Receptors; C495677:SLC2A1 protein, human; C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I