title: Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.
abstract: OBJECTIVE
  Overexpression of fatty acid synthase (FASN), the enzyme involved in the de novo synthesis of fatty acids, has been reported in several human carcinomas, including breast cancer, and has been related to poor prognosis. Our aim was to analyze the association of FASN tumor tissue expression with clinicopathological and anthropometrical features in early-stage breast cancer patients.
  
  
  METHODS
  We prospectively studied 53 women with early-stage breast cancer who were treated with surgical operation and postoperative chemotherapy.
  
  
  RESULTS
  Menopause status and age were strongly associated with higher levels of FASN tumor expression (P < 0.005 and P = 0.038, respectively). Body mass index and pathological stage were also related to FASN tumor expression.
  
  
  CONCLUSIONS
  Our findings suggest that FASN could be a potential therapeutic target in postmenopausal breast cancer patients. However, further studies are needed.
authors: From the 1Medical Oncology Department, Catalan Institute of Oncology and Girona Biomedical Research Institute, Girona, Spain; 2Molecular Oncology (NEOMA), Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain; 3Research Institute of Santa Caterina Hospital, Salt, Girona, Spain; and 4Department of Pathology, Dr. Josep Trueta University Hospital of Girona, Girona, Spain.
authors: Rut
authors: R
authors: Porta
authors: Adriana
authors: A
authors: Blancafort
authors: Gemma
authors: G
authors: Casòliva
authors: Miquel
authors: M
authors: Casas
authors: Joan
authors: J
authors: Dorca
authors: Maria
authors: M
authors: Buxo
authors: Gemma
authors: G
authors: Viñas
authors: Glòria
authors: G
authors: Oliveras
authors: Teresa
authors: T
authors: Puig
mesh_terms: D000328:Adult; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003430:Cross-Sectional Studies; D054890:Fatty Acid Synthase, Type I / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008593:Menopause / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology; D011379:Prognosis; D011446:Prospective Studies; D013030:Spain
chemical_list: C518729:FASN protein, human; D054890:Fatty Acid Synthase, Type I