title: Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge.
abstract: Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters. Structures of the obtained compounds were established by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Configurations of the triterpene epoxy lactones (1-4) were determined on the basis of NOESY and CD data and calculation of spin coupling constants and confirmed by X-ray crystallographic analysis of compound 2. The isolated triterpenoid 6 was cytotoxic against human leukemia HL-60 cells (IC₅₀ = 9.7 μM).
authors: G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russian Federation.
authors: Sophia A
authors: SA
authors: Kolesnikova
authors: Ekaterina G
authors: EG
authors: Lyakhova
authors: Anatoly I
authors: AI
authors: Kalinovsky
authors: Michail A
authors: MA
authors: Pushilin
authors: Shamil Sh
authors: SSh
authors: Afiyatullov
authors: Ekaterina A
authors: EA
authors: Yurchenko
authors: Sergey A
authors: SA
authors: Dyshlovoy
authors: Chau V
authors: CV
authors: Minh
authors: Valentin A
authors: VA
authors: Stonik
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014744:Vietnam
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; C093431:penasterone; D007810:Lanosterol