title: Preparation and characterization of hydrophilic composites AA/EPMA loaded with hydroxyapatite.
abstract: Copolymeric composites of acrylamide (AA) and 2,3-epoxypropyl methacrylate (EPMA) with hydroxyapatite (HA) load were studied. Swelling studies reports an anomalous or non-Fickian behavior following a good fitting to a pseudo second order mathematical treatment (α = 0.05, p < 0.0001). The composites showed a strong dependence on pH, related with the variations in the swelling behavior. The addition of load induces a diminution of swelling capacity and an increase of diametric tensile strength (DTS) ranging between 20 and 90 kPa. The calorimetric experiments showed two steps at 78°C and 255°C assigned to water loss and samples Tg. The drug control released was adjusted to a two-term equation obtaining a diffusion coefficient around 10(-5) cm(2) /s. The samples showed a significant bioactivity in vitro and it was certified by SEM, EDS and surface area calculus.
authors: Biomaterials Center, University of Havana, Ave. Universidad e/ G y Ronda, Vedado, Plaza, La Habana, 10400, Cuba.
authors: Yaima
authors: Y
authors: Campos
authors: Gastón
authors: G
authors: Fuentes
authors: José A
authors: JA
authors: Delgado
authors: Amisel
authors: A
authors: Almirall
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002437:Cefazolin / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D013696:Temperature; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D004852:Epoxy Compounds; D008689:Methacrylates; D020106:Acrylamide; D017886:Durapatite; D002437:Cefazolin; C007870:glycidyl methacrylate
keywords: acrylic monomers; bioactivity; composites; hydrophilic properties; mechanical properties