title: The effect of a first-generation H1-antihistamine on postural control: a preliminary study in healthy volunteers.
abstract: First-generation H1-antihistamines are known to cause fatigue and drowsiness, due to their poor receptor selectivity and their high penetration rate of the blood-brain barrier. However, little is known about the effects of first-generation H1-antihistamines on postural stability. The purpose of this study was to evaluate the effects of d-chlorpheniramine on postural stability using posturography with and without foam rubber. A double-blind study with three parallel groups was conducted. Twenty-seven healthy young volunteers (mean age 21.9 years) were recruited and orally administered d-chlorpheniramine, 2 or 4 mg, or placebo. Postural sway was measured every hour up to 8 h after administration. Two-legged stance tasks were performed by each subject in four conditions: eyes open or eyes closed and with or without foam rubber. Inter-group comparisons showed that the group receiving 4-mg d-chlorpheniramine showed significantly larger sway in the eyes open with foam rubber condition (visual and vestibular information available, somatosensory information reduced). Inter-subject analysis in the 4-mg d-chlorpheniramine group showed that the effect of d-chlorpheniramine on postural control was variable. Our results suggest that among the three main sensory systems responsible for postural control (visual, vestibular, and somatosensory), d-chlorpheniramine may have a larger effect on the visual and/or vestibular systems in susceptible individuals.
authors: National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 1528902, Japan, y-chihara@umin.ac.jp.
authors: Yasuhiro
authors: Y
authors: Chihara
authors: Ayako
authors: A
authors: Sato
authors: Michiteru
authors: M
authors: Ohtani
authors: Chisato
authors: C
authors: Fujimoto
authors: Takahiro
authors: T
authors: Hayashi
authors: Hironobu
authors: H
authors: Nishijima
authors: Masato
authors: M
authors: Yagi
authors: Shinichi
authors: S
authors: Iwasaki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001696:Biomechanical Phenomena; D002744:Chlorpheniramine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D019277:Entropy; D005123:Eye; D005260:Female; D064368:Healthy Volunteers; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture / Q000502:physiology; D055815:Young Adult
chemical_list: D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine
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