title: Senescence at a glance.
abstract: Cellular senescence is a stable proliferation arrest that is associated with extensive cellular remodelling and an altered secretory pathway. Through its numerous inducers that lead to altered gene expression, senescence is able to influence many contrasting functions and pathologies, namely tumour suppression, tumour promotion, wound healing and ageing. As senescence is able to control such important tissue functions, it is now being pinpointed as a possible route for novel therapies. This article and accompanying poster aim to provide a summary of the initiators, pathways and roles of senescence, as well as present examples of senescence and a possible use for senescence in therapy.
authors: Institute of Cancer Sciences, Cancer Research UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, UK.
authors: Jeff S
authors: JS
authors: Pawlikowski
authors: Peter D
authors: PD
authors: Adams
authors: David M
authors: DM
authors: Nelson
mesh_terms: D049109:Cell Proliferation; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D015398:Signal Transduction
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