title: Development of an expedient intramolecular Pauson-Khand reaction approach to stereoselectively construct the trans-decalin with a C1 quaternary chiral center.
abstract: Stereoselective synthesis of the trans-decalin subunit with a defined C1 quaternary chiral center has been achieved by the Pauson-Khand reaction (PKR) as a key step. The developed chemistry offers an alternative to the IMDA reaction that has been used for the syntheses of trans-decalin based biologically active natural products.
authors: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. chuangli@pku.edu.cn zyang@pku.edu.cn.
authors: Li-Li
authors: LL
authors: Shi
authors: Hong-Juan
authors: HJ
authors: Shen
authors: Li-Chao
authors: LC
authors: Fang
authors: Jun
authors: J
authors: Huang
authors: Chuang-Chuang
authors: CC
authors: Li
authors: Zhen
authors: Z
authors: Yang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D003517:Cyclopentanes; D009281:Naphthalenes; C007201:cyclopentanone; C007229:decalin