title: Are there differences in LDL-C target value attainment in Austrian federal states? Yes!
abstract: Low density lipoprotein (LDL-C) levels determine the cardiovascular risk. Previous studies indicated an LDL-C target attainment of around 50%, but no Austrian wide analysis on results for the federal states was available. We therefore sought to detect potential differences.
  
  
  METHODS
  Open-label, non-interventional, longitudinal study, registered: www.clinicaltrials.gov NCT 01381679. In all, 746 statin treated patients not at LDL-C goal received intensified therapy for 12 months. The sample was split into nine subgroups, representing the federal states of Austria.We detected an east-west gradient for baseline LDL-C. Individual target values were achieved by 37.2% (range: 26.1-57.7%). After 12 months, LDL-C < 70 mg/l was achieved by 13.5% (5.9-38.5%). Univariate ANCOVA retrieved significant differences within the states (Upper Austria and Salzburg, p = 0.001 and p = 0.0015, respectively). Furthermore, the capacity of intensified lipid lowering therapy applied in practice was as high as -42% as compared to previous standard therapy (additional LDL-C reduction after switch from baseline therapy in Vorarlberg).
authors: Paracelsus Medical University, Salzburg, Austria.
authors: Max
authors: M
authors: Pichler
authors: Dominik
authors: D
authors: Lautsch
authors: Claudia
authors: C
authors: Adler
authors: Karl
authors: K
authors: Bögl
authors: Heinz
authors: H
authors: Drexel
authors: Bernd
authors: B
authors: Eber
authors: Christiane
authors: C
authors: Fauer
authors: Johannes
authors: J
authors: Föchterle
authors: Bernhard
authors: B
authors: Föger
authors: Karin
authors: K
authors: Gansch
authors: Peter
authors: P
authors: Grafinger
authors: Monika
authors: M
authors: Lechleitner
authors: Bernhard
authors: B
authors: Ludvik
authors: Gerald
authors: G
authors: Maurer
authors: Reinhard
authors: R
authors: Mörz
authors: Bernhard
authors: B
authors: Paulweber
authors: Karl Peter
authors: KP
authors: Pfeiffer
authors: Rudolf
authors: R
authors: Prager
authors: Gerhard
authors: G
authors: Stark
authors: Hermann
authors: H
authors: Toplak
authors: Otto
authors: O
authors: Traindl
authors: Raimund
authors: R
authors: Weitgasser
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001317:Austria; D001384:Azetidines / Q000627:therapeutic use*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D004351:Drug Resistance; D000069438:Ezetimibe; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019233:Retreatment; D019371:Topography, Medical
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000069438:Ezetimibe
references: Can J Cardiol. 1988 Jul;4 Suppl A:5A-10A
references: 3179802
references: N Engl J Med. 2008 Nov 20;359(21):2195-207
references: 18997196
references: J Geriatr Cardiol. 2011 Mar;8(1):1-11
references: 22783278
references: Circulation. 2009 Jul 7;120(1):28-34
references: 19546386
references: Atherosclerosis. 2011 Jul;217 Suppl 1:S1-44
references: 21723445
references: Eur J Prev Cardiol. 2012 Apr;19(2):221-30
references: 21450578
references: Eur Heart J. 2008 Apr;29(7):932-40
references: 18334475
references: Eur Heart J. 2007 Oct;28(19):2375-414
references: 17726041
references: J Intern Med. 2009 May;265(5):568-80
references: 19141093
references: Int J Clin Pract. 2009 Apr;63(4):547-59
references: 19222610
references: Lancet. 2011 Jun 25;377(9784):2181-92
references: 21663949
references: Wien Klin Wochenschr. 2011 Jan;123(1-2):21-7
references: 21165704
references: Stroke. 2012 Apr;43(4):1153-5
references: 22223239
references: Curr Med Res Opin. 2012 Sep;28(9):1447-54
references: 22856551
references: Eur Heart J. 2012 Jul;33(13):1635-701
references: 22555213
references: Wien Klin Wochenschr. 2012 Jun;124(11-12):363-9
references: 22661048
references: Am J Cardiol. 2008 Dec 1;102(11):1489-94
references: 19026302
references: Lancet. 2009 Mar 14;373(9667):929-40
references: 19286092
references: N Engl J Med. 2011 Dec 1;365(22):2078-87
references: 22085316
references: Circulation. 2004 Jul 13;110(2):227-39
references: 15249516
references: Am J Cardiol. 2010 Jan 1;105(1):69-76
references: 20102893
references: N Engl J Med. 2005 Apr 7;352(14):1425-35
references: 15755765
references: Int J Health Geogr. 2011 Nov 14;10:59
references: 22082341
references: Curr Med Res Opin. 2008 Mar;24(3):685-94
references: 18226326
references: J Am Coll Cardiol. 2009 Nov 3;54(19):1787-94
references: 19874992
references: Wien Klin Wochenschr. 2011 Oct;123(19-20):611-7
references: 21947362
references: Wien Klin Wochenschr. 2008;120(17-18):558-65
references: 18988009
references: Lancet. 2010 Nov 13;376(9753):1670-81
references: 21067804
references: N Engl J Med. 2004 Apr 8;350(15):1495-504
references: 15007110