title: [Relationship between early serum lipid profiles and respiratory distress syndrome in preterm infants].
abstract: OBJECTIVE
  To investigate early serum lipid profiles in preterm infants and their relationship with neonatal respiratory distress syndrome (RDS).
  
  
  METHODS
  Appropriate-for-gestational-age (AGA) preterm infants were grouped according to gestational age (GA) or birth weight (BW). AGA full-term infants were randomly selected as the control group. Venous blood samples were collected within 12 hours after birth for measurement of biochemical indices, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG). Blood lipid levels were compared between preterm infants with and without RDS in various groups.
  
  
  RESULTS
  Plasma TG level rose as GA and BW increased. Plasma TG levels in the 28-30 week and 31-33 week GA groups were significantly lower than in the 34-36 week GA and control groups (P<0.01). Plasma TG levels in the ≤ 1499 g and 1500-2499 g BW groups were significantly lower than in the ≥ 2500 g BW and control groups (P<0.05), and the 1500-2499 g BW group had a significantly higher plasma TG level than the ≤ 1499 g BW group (P<0.01). There were no significant differences in plasma HDL-C, LDL-C and TC levels between all groups and between preterm infants with RDS and without RDS. In the 28-30 week GA group, the preterm infants with RDS had a significantly lower TG level than those without RDS (P<0.05); also, in the ≤ 1499 g BW group, preterm infants with RDS had a significantly lower TG level than those without RDS ( P<0.05).
  
  
  CONCLUSIONS
  Blood lipid levels are related to GA and BW. Low TG level may be one of the causes of RDS in preterm infants with a gestational age of 28-30 weeks and a BW of ≤ 1499 g.
authors: Neonatal Intensive Care Unit, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. bjtong2007@163.com.
authors: Hua
authors: H
authors: Wang
authors: Wei
authors: W
authors: Zhang
authors: Jing
authors: J
authors: Wang
authors: Hui-Ling
authors: HL
authors: Li
authors: Chun-Ling
authors: CL
authors: Wen
mesh_terms: D001724:Birth Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol