title: A physical explanation of the temperature dependence of physiological processes mediated by cilia and flagella.
abstract: The majority of biological rates are known to exhibit temperature dependence. Here I reveal a direct link between temperature and ecologically relevant rates such as swimming speeds in Archaea, Bacteria, and Eukaryotes as well as fluid-pumping and filtration rates in many metazoans, and show that this relationship is driven by movement rates of cilia and flagella. I develop models of the temperature dependence of cilial and flagellar movement rates and evaluate these with an extensive compilation of data from the literature. The model captures the temperature dependence of viscosity and provides a mechanistic and biologically interpretable explanation for the temperature dependence of a range of ecologically relevant processes; it also reveals a clear dependence on both reaction rate-like processes and the physics of the environment. The incorporation of viscosity allows further insight into the effects of environmental temperature variation and of processes, such as disease, that affect the viscosity of blood or other body fluids.
authors: School of Biological, Biomedical and Environmental Sciences, University of Hull, Kingston-upon-Hull HU6 7RX, United Kingdom. s.humphries@hull.ac.uk
authors: Stuart
authors: S
authors: Humphries
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000465:Algorithms; D000818:Animals; D002468:Cell Physiological Phenomena / Q000502:physiology; D002923:Cilia / Q000502:physiology*; D005407:Flagella / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D013045:Species Specificity; D013696:Temperature
chemical_list: D000255:Adenosine Triphosphate
keywords: Arrhenius; biological fluid dynamics
references: Am Nat. 2004 Mar;163(3):429-41
references: 15026978
references: J Exp Biol. 2010 Dec 15;213(Pt 24):4223-31
references: 21113003
references: Proc Natl Acad Sci U S A. 1974 Aug;71(8):3253-4
references: 4213062
references: Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10591-6
references: 21606358
references: Science. 1992 Mar 13;255(5050):1421-3
references: 17801232
references: Biochim Biophys Acta. 2002 Mar 25;1595(1-2):367-81
references: 11983409
references: Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15670-5
references: 20798342
references: Biophys J. 2006 Feb 1;90(3):811-21
references: 16284275
references: Biophys J. 2010 Feb 17;98(4):617-26
references: 20159158
references: Prog Clin Biol Res. 1982;80:25-8
references: 7048323
references: Ecol Lett. 2012 Dec;15(12):1465-74
references: 22931542
references: Biophys J. 2008 Jan 1;94(1):298-305
references: 17872955
references: Science. 2001 Sep 21;293(5538):2248-51
references: 11567137
references: South Med J. 2010 Sep;103(9):892-5
references: 20689477
references: Curr Biol. 2004 May 4;14(9):R355-6
references: 15120091
references: Cell Motil Cytoskeleton. 2009 Apr;66(4):220-36
references: 19243024
references: Appl Environ Microbiol. 2005 Feb;71(2):921-9
references: 15691949
references: Nature. 2004 Feb 12;427(6975):649-52
references: 14961123
references: J Cell Biol. 1981 Dec;91(3 Pt 1):689-94
references: 6460037
references: Biol Cell. 1992;76(3):335-8
references: 1305479
references: Nat Rev Microbiol. 2005 Jul;3(7):537-46
references: 15953930
references: J Exp Biol. 1966 Aug;45(1):113-39
references: 6007962
references: Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1260-5
references: 16432218
references: Proc Natl Acad Sci U S A. 2004 May 11;101(19):7234-9
references: 15118088
references: Science. 1994 Jul 1;265(5168):100-3
references: 17774697
references: Clin Otolaryngol Allied Sci. 1998 Oct;23(5):403-13
references: 9800075