title: Dynamin rings: not just for fission.
abstract: The GTPase dynamin has captivated researchers for over two decades, even managing to establish its own research field. Dynamin's allure is partly due to its unusual biochemical properties as well as its essential role in multiple cellular processes, which include the regulation of clathrin-mediated endocytosis and of actin cytoskeleton. On the basis of the classic model, dynamin oligomerization into higher order oligomers such as rings and helices directly executes the final fission reaction in endocytosis, which results in the generation of clathrin-coated vesicles. Dynamin's role in the regulation of actin cytoskeleton is mostly explained by its interactions with a number of actin-binding and -regulating proteins; however, the molecular mechanism of dynamin's action continues to elude us. Recent insights into the mechanism and role of dynamin oligomerization in the regulation of actin polymerization point to a novel role for dynamin oligomerization in the cell.
authors: Nephrology Division, Massachusetts General Hospital, CNY 149 8.113, 149 13th Street, Charlestown, MA, 02129, USA.
authors: Sanja
authors: S
authors: Sever
authors: Joann
authors: J
authors: Chang
authors: Changkyu
authors: C
authors: Gu
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D055503:Protein Multimerization
chemical_list: D034281:Dynamins
keywords: dynamin actin; endocytosis; microtubules; oligomerization
references: Dev Cell. 2009 Dec;17(6):811-22
references: 20059951
references: J Cell Biol. 2005 Apr 11;169(1):117-26
references: 15824135
references: J Cell Biol. 2000 Sep 4;150(5):1137-48
references: 10974001
references: EMBO J. 2006 Sep 20;25(18):4163-74
references: 16946707
references: Traffic. 2000 May;1(5):385-92
references: 11208124
references: Cell Signal. 1999 Jan;11(1):25-9
references: 10206341
references: Nature. 1999 Apr 8;398(6727):481-6
references: 10206643
references: Mol Biol Cell. 2003 Mar;14(3):1085-96
references: 12631725
references: Nature. 1995 Mar 9;374(6518):190-2
references: 7877694
references: Mol Biol Cell. 2005 Apr;16(4):2058-67
references: 15703209
references: Dev Cell. 2007 Jul;13(1):43-56
references: 17609109
references: Nat Cell Biol. 2004 Apr;6(4):335-42
references: 15048127
references: Annu Rev Biophys. 2013;42:629-49
references: 23541160
references: Nature. 1990 Sep 20;347(6290):256-61
references: 2144893
references: PLoS Biol. 2012;10(4):e1001302
references: 22505844
references: Dev Cell. 2006 Jun;10(6):839-50
references: 16740485
references: Nature. 2001 Mar 8;410(6825):231-5
references: 11242086
references: J Cell Biol. 1997 Aug 25;138(4):771-81
references: 9265645
references: Traffic. 2011 Nov;12(11):1620-33
references: 21762456
references: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):161-6
references: 11782545
references: Cell. 2011 Sep 30;147(1):209-22
references: 21962517
references: Nature. 2011 Sep 18;477(7366):556-60
references: 21927000
references: Nat Cell Biol. 2003 Jul;5(7):599-609
references: 12833063
references: Annu Rev Cell Dev Biol. 2000;16:483-519
references: 11031245
references: J Cell Biol. 2009 Jun 15;185(6):939-48
references: 19528294
references: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20770-5
references: 19948954
references: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):167-72
references: 11782546
references: Mol Biol Cell. 2004 Jan;15(1):256-67
references: 14617821
references: PLoS One. 2013;8(1):e55691
references: 23383266
references: Annu Rev Cell Dev Biol. 2011;27:79-105
references: 21599493
references: PLoS Biol. 2009 Mar 17;7(3):e57
references: 19296720
references: Mol Biol Cell. 1992 Oct;3(10):1181-94
references: 1421574
references: J Biol Chem. 2009 Sep 4;284(36):23995-4005
references: 19605363
references: PLoS Biol. 2011 Mar;9(3):e1000604
references: 21445324
references: Nature. 1991 May 30;351(6325):411-4
references: 1674590
references: J Neurosci. 2013 Mar 6;33(10):4514-26
references: 23467367
references: EMBO J. 2010 Nov 3;29(21):3593-606
references: 20935625
references: Cell Rep. 2012 Nov 29;2(5):1111-9
references: 23103167
references: Curr Biol. 2002 Dec 23;12(24):2111-7
references: 12498685
references: J Cell Biol. 1987 Mar;104(3):491-501
references: 3029140
references: Curr Biol. 2002 Oct 29;12(21):1852-7
references: 12419186
references: J Am Soc Nephrol. 2005 Dec;16(12):3694-701
references: 16251236
references: J Biol Chem. 1996 Sep 13;271(37):22310-4
references: 8798389
references: J Cell Biol. 2000 Oct 2;151(1):187-98
references: 11018064
references: Science. 2013 Mar 22;339(6126):1433-6
references: 23520112
references: EMBO J. 1997 Nov 17;16(22):6676-83
references: 9362482
references: Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47
references: 15040446
references: Cell. 1989 Nov 3;59(3):421-32
references: 2529977
references: Cell. 2012 Mar 30;149(1):124-36
references: 22464325
references: Nat Cell Biol. 2001 Oct;3(10):922-6
references: 11584275
references: Mol Biol Cell. 2003 Mar;14(3):1074-84
references: 12631724
references: J Biol Chem. 2003 Nov 14;278(46):45672-9
references: 12952985
references: Semin Cell Dev Biol. 2011 Feb;22(1):10-7
references: 20837154
references: Biophys J. 2011 Feb 2;100(3):729-737
references: 21281588
references: FASEB J. 2006 Oct;20(12):2050-7
references: 17012257
references: J Cell Biol. 2000 Jul 24;150(2):377-89
references: 10908579
references: Biophys J. 2010 Sep 22;99(6):1852-60
references: 20858430
references: J Biol Chem. 2013 Mar 1;288(9):6651-61
references: 23297414
references: Mol Biol Cell. 2005 Jul;16(7):3301-13
references: 15872089
references: Curr Opin Cell Biol. 2010 Aug;22(4):430-6
references: 20605711