title: Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest Ethiopia: A Case-Control Study.
abstract: BACKGROUND
  Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfected patients.
  
  
  METHODS
  We conducted an unmatched case-control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfected patients who were alive during the end of the follow-up period.
  
  
  RESULTS
  Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfected patients.
  
  
  CONCLUSIONS
  Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
authors: Department of Epidemiology, Jimma University, Jimma, Ethiopia kebededeka@yahoo.com.
authors: Kebede
authors: K
authors: Deribe
authors: Department of Internal Medicine, Jimma University, Jimma, Ethiopia.
authors: Alemeshet
authors: A
authors: Yami
authors: Department of Epidemiology, Jimma University, Jimma, Ethiopia.
authors: Amare
authors: A
authors: Deribew
authors: Department of Internal Medicine, Jimma University, Jimma, Ethiopia Department of Internal Medicine, Gondar University, Gondar, Ethiopia.
authors: Nebiyu
authors: N
authors: Mesfin
authors: Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
authors: Robert
authors: R
authors: Colebunders
authors: Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium.
authors: Jean Pierre
authors: JP
authors: Van Geertruyden
authors: Department of Health Services Management, Jimma University, Jimma, Ethiopia.
authors: Mirkuzie
authors: M
authors: Woldie
authors: Department of Health Studies, UNISA, Pretoria, South Africa.
authors: Todd
authors: T
authors: Maja
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D015331:Cohort Studies; D060085:Coinfection / Q000401:mortality*; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000097:blood / Q000150:complications / Q000401:mortality*; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Ethiopia; TB/HIV coinfection; mortality; tuberculosis
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