title: Cerebrospinal fluid Aβ42, phosphorylated Tau181, and resting-state functional connectivity.
abstract: OBJECTIVE
  Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease.
  
  
  OBJECTIVE
  To assess the relationship between default mode network integrity and cerebrospinal fluid biomarkers of Alzheimer disease pathology in cognitively normal older individuals.
  
  
  METHODS
  Cross-sectional cohort study at The Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University in St Louis, St Louis, Missouri, among 207 older adults with normal cognition (Clinical Dementia Rating, 0).
  
  
  METHODS
  Resting-state functional connectivity magnetic resonance imaging measures of default mode network integrity.
  
  
  RESULTS
  Decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 were independently associated with reduced default mode network integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions. Observed reductions in functional connectivity were unattributable to age or structural atrophy in the posterior cingulate and medial temporal areas. Similar resting-state functional connectivity magnetic resonance imaging findings in relation to cerebrospinal fluid biomarkers were obtained using region-of-interest analyses and voxelwise correlation mapping.
  
  
  CONCLUSIONS
  Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer disease.
authors: Liang
authors: L
authors: Wang
authors: Matthew R
authors: MR
authors: Brier
authors: Abraham Z
authors: AZ
authors: Snyder
authors: Jewell B
authors: JB
authors: Thomas
authors: Anne M
authors: AM
authors: Fagan
authors: Chengjie
authors: C
authors: Xiong
authors: Tammie L
authors: TL
authors: Benzinger
authors: David M
authors: DM
authors: Holtzman
authors: John C
authors: JC
authors: Morris
authors: Beau M
authors: BM
authors: Ances
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D012111:Residence Characteristics; D012146:Rest / Q000502:physiology*; D018709:Statistics, Nonparametric; D013912:Threonine / Q000378:metabolism*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D013912:Threonine; D010100:Oxygen
references: Brain. 2006 Nov;129(Pt 11):3035-41
references: 17012293
references: Ann Neurol. 1999 Mar;45(3):358-68
references: 10072051
references: Acta Neuropathol. 1991;82(4):239-59
references: 1759558
references: Prog Neurobiol. 2011 Dec;95(4):579-93
references: 21130138
references: J Neurosci. 2012 Jun 13;32(24):8254-62
references: 22699906
references: J Comp Neurol. 2003 Nov 3;466(1):48-79
references: 14515240
references: Lancet Neurol. 2010 Nov;9(11):1118-27
references: 20934914
references: Neurology. 2000 Aug 8;55(3):370-6
references: 10932270
references: J Neuropathol Exp Neurol. 2003 Nov;62(11):1087-95
references: 14656067
references: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references: 18400922
references: Alzheimers Dement. 2011 May;7(3):280-92
references: 21514248
references: EMBO Mol Med. 2009 Nov;1(8-9):371-80
references: 20049742
references: Ann Neurol. 2003 Aug;54(2):163-9
references: 12891668
references: Nat Rev Neurol. 2010 Mar;6(3):131-44
references: 20157306
references: J Neurosci. 2005 Aug 24;25(34):7709-17
references: 16120771
references: Brain. 2011 Jun;134(Pt 6):1635-46
references: 21490054
references: Ann Neurol. 2010 Jan;67(1):122-31
references: 20186853
references: Sci Rep. 2013;3:1339
references: 23439248
references: Ann Neurol. 2006 Mar;59(3):512-9
references: 16372280
references: Alzheimers Dement. 2011 May;7(3):257-62
references: 21514247
references: J Neurochem. 2007 Jun;101(5):1172-84
references: 17286590
references: Neuroimage. 2010 Jun;51(2):910-7
references: 20188183
references: Nat Med. 2008 Aug;14(8):837-42
references: 18568035
references: Arch Neurol. 2001 Sep;58(9):1395-402
references: 11559310
references: J Neurosci. 2012 Jun 27;32(26):8890-9
references: 22745490
references: JAMA. 2003 Apr 23-30;289(16):2094-103
references: 12709467
references: Curr Opin Neurol. 2008 Aug;21(4):424-30
references: 18607202
references: J Neurosci. 2010 Dec 15;30(50):17035-40
references: 21159973
references: Magn Reson Med. 1995 Oct;34(4):537-41
references: 8524021
references: Arch Neurol. 2011 Sep;68(9):1131-6
references: 21555604
references: Nat Neurosci. 2010 Jul;13(7):812-8
references: 20581818
references: J Neurosci. 2009 Oct 7;29(40):12686-94
references: 19812343
references: Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4):210-6
references: 17132964
references: Neurology. 2006 Aug 8;67(3):446-52
references: 16894106
references: Neurology. 2006 Jun 27;66(12):1837-44
references: 16801647
references: Ann Neurol. 2012 Oct;72(4):571-7
references: 23109152
references: J Neurosci. 1996 Jul 15;16(14):4491-500
references: 8699259
references: Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10041-5
references: 16785436
references: Biol Psychiatry. 2010 Mar 15;67(6):584-7
references: 19833321
references: Arch Neurol. 1998 Mar;55(3):326-35
references: 9520006
references: Cereb Cortex. 2010 Dec;20(12):2852-62
references: 20237243
references: Neuroimage. 2012 Feb 1;59(3):2142-54
references: 22019881
references: Neurology. 1993 Nov;43(11):2412-4
references: 8232972
references: Neuron. 2010 Nov 4;68(3):428-41
references: 21040845
references: Cereb Cortex. 2011 Oct;21(10):2399-407
references: 21383234
references: Neuromolecular Med. 2010 Mar;12(1):27-43
references: 20069392
references: Arch Neurol. 2007 Mar;64(3):343-9
references: 17210801
references: Ann Neurol. 2004 Mar;55(3):306-19
references: 14991808
references: Cereb Cortex. 1991 Jan-Feb;1(1):103-16
references: 1822725