title: Food protein-induced enterocolitis syndrome, from practice to theory.
abstract: Food protein-induced enterocolitis syndrome (FPIES) is an allergic disease, probably non-IgE-mediated, with expression predominantly in the GI tract. The most characteristic symptom is repeated, debilitating vomiting. It occurs 2-6 h after ingestion of culprit food and is usually accompanied by pallor and lethargy. There may be diarrhea, and in 10-20% of cases, severe hypotension. These symptoms resolve completely within a few hours. The food most frequently involved is cow's milk, followed by rice, but many other foods may be involved. The prognosis is generally good in a few years. In this review the authors try to cope, with the help of some case histories, with the practical clinical aspects of FPIES. The authors also try to provide a management approach based on current knowledge, and finally, to point out the aspects of FPIES that are still controversial.
authors: Department of Paediatrics, Catholic University of Sacred Heart, L.go Gemelli 8, Rome 00168, Italy. stefano.micelisopo@gmail.com
authors: Stefano
authors: S
authors: Miceli Sopo
authors: Monica
authors: M
authors: Greco
authors: Serena
authors: S
authors: Monaco
authors: Salvatore
authors: S
authors: Tripodi
authors: Mauro
authors: M
authors: Calvani
mesh_terms: D017668:Age of Onset; D000818:Animals; D002417:Cattle; D003348:Cortisone / Q000627:therapeutic use; D004035:Diet Therapy; D004760:Enterocolitis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005502:Food / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D007022:Hypotension; D007223:Infant; D008297:Male; D013577:Syndrome; D014839:Vomiting
chemical_list: D003348:Cortisone