title: Evaluating the arcuate fasciculus with combined diffusion-weighted MRI tractography and electrocorticography.
abstract: The conventional model of language-related brain structure describing the arcuate fasciculus as a key white matter tract providing a direct connection between Wernicke's region and Broca's area has been called into question. Specifically, the inferior precentral gyrus, possessing both primary motor (Brodmann Area [BA] 4) and premotor cortex (BA 6), has been identified as a potential alternative termination. The authors initially localized cortical sites involved in language using measurement of event-related gamma-activity on electrocorticography (ECoG). The authors then determined whether language-related sites of the temporal lobe were connected, via white matter structures, to the inferior frontal gyrus more tightly than to the precentral gyrus. The authors found that language-related sites of the temporal lobe were far more likely to be directly connected to the inferior precentral gyrus through the arcuate fasciculus. Furthermore, tractography was a significant predictor of frontal language-related ECoG findings. Analysis of an interaction between anatomy and tractography in this model revealed tractrography to have the highest predictive value for language-related ECoG findings of the precentral gyrus. This study failed to support the conventional model of language-related brain structure. More feasible models should include the inferior precentral gyrus as a termination of the arcuate fasciculus. The exact functional significance of direct connectivity between temporal language-related sites and the precentral gyrus requires further study.
authors: MD/PhD Program, School of Medicine, Wayne State University, Detroit, Michigan; Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, Michigan.
authors: Erik C
authors: EC
authors: Brown
authors: Jeong-Won
authors: JW
authors: Jeong
authors: Otto
authors: O
authors: Muzik
authors: Robert
authors: R
authors: Rothermel
authors: Naoyuki
authors: N
authors: Matsuzaki
authors: Csaba
authors: C
authors: Juhász
authors: Sandeep
authors: S
authors: Sood
authors: Eishi
authors: E
authors: Asano
mesh_terms: D000293:Adolescent; D001111:Arcuate Nucleus of Hypothalamus / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D021621:Imaging, Three-Dimensional; D007802:Language; D008297:Male; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D055815:Young Adult
keywords: DTI; connectivity; event-related augmentation of gamma-activity; high-frequency oscillations (HFOs); naming; ripples; speech; tractography
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