title: Antitumor and scavenging radicals activities of some polyphenols related to dehydroabietylamine derivatives.
abstract: A novel series of polyphenols 4-9 were synthesized by the reaction of catechol with dehydroabietylamine derivatives. The antitumor activities of these compounds against L02 and HepG2 cells were investigated. Among them, compounds 4, 5, and 9 can inhibit HepG2 cells viability, but have lower inhibitory effect on L02 cells in the same concentration, indicating their potential for further development. Meanwhile, the novel series of polyphenols exhibited stronger radical-scavenging activities than the control groups.
authors: a College of Chemical Engineering, Nanjing Forestry University , Nanjing , 210037 , China.
authors: Chao-Xiang
authors: CX
authors: Liu
authors: Zhong-Xiang
authors: ZX
authors: Lin
authors: Zhou
authors: Z
authors: Lu
authors: Yi-Meng
authors: YM
authors: Wang
authors: Yong-Li
authors: YL
authors: Bao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D059808:Polyphenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D002396:Catechols; D004224:Diterpenes; D016166:Free Radical Scavengers; D010851:Picrates; D059808:Polyphenols; C004931:1,1-diphenyl-2-picrylhydrazyl; C034221:catechol