title: Impact of the histological type on the prognosis of patients with prenatally diagnosed sacrococcygeal teratomas: the results of a nationwide Japanese survey.
abstract: OBJECTIVE
  To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan.
  
  
  METHODS
  A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously.
  
  
  RESULTS
  The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated.
  
  
  CONCLUSIONS
  Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases.
authors: Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan, ayoneda@mch.pref.osaka.jp.
authors: Akihiro
authors: A
authors: Yoneda
authors: Noriaki
authors: N
authors: Usui
authors: Tomoaki
authors: T
authors: Taguchi
authors: Yoshihiro
authors: Y
authors: Kitano
authors: Haruhiko
authors: H
authors: Sago
authors: Yutaka
authors: Y
authors: Kanamori
authors: Tomoo
authors: T
authors: Nakamura
authors: Shunsuke
authors: S
authors: Nosaka
authors: Mari S
authors: MS
authors: Oba
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology / Q000473:pathology*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D010386:Pelvic Neoplasms / Q000453:epidemiology / Q000473:pathology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D012445:Sacrococcygeal Region; D015996:Survival Rate / Q000639:trends; D013724:Teratoma / Q000453:epidemiology / Q000473:pathology*
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