title: Briefing in family characteristics of microRNAs and their applications in cancer research.
abstract: MicroRNAs (miRNAs) are endogenous, short, non-coding RNA molecules that are directly involved in the post-transcriptional regulation of gene expression. Dysregulation of miRNAs is usually associated with diseases. Since miRNAs in a family intend to have common functional characteristics, proper assignment of miRNA family becomes heuristic for better understanding of miRNA nature and their potentials in clinic. In this review, we will briefly discuss the recent progress in miRNA research, particularly its impact on protein and its clinical application in cancer research in a view of miRNA family. This article is part of a Special Issue entitled: Computational Proteomics, Systems Biology & Clinical Implications. Guest Editor: Yudong Cai.
authors: School of Information Science and Technology, Xiamen University, Xiamen, 361005 Fujian, PR China.
authors: Qicong
authors: Q
authors: Wang
authors: Leyi
authors: L
authors: Wei
authors: Xinjun
authors: X
authors: Guan
authors: Yunfeng
authors: Y
authors: Wu
authors: Quan
authors: Q
authors: Zou
authors: ZhiLiang
authors: Z
authors: Ji
mesh_terms: D019295:Computational Biology / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D040901:Proteomics; D049490:Systems Biology
chemical_list: D035683:MicroRNAs
keywords: Cancer therapy; MicroRNA; miRNA family