title: Thr698Thr (nt2369) polymorphism on CACNA1A gene and head pain severity in familial migraine.
abstract: BACKGROUND
  Migraine is a common neurological disorder with a significant genetic component. Less information is known about the contribution of minor genetic variations, such as single nucleotide polymorphism (SNP) on the migraine process. In the present study, we aim to investigate the role of CACNA1A gene polymorphism on severity and related factors in family positive migraine patients.
  
  
  METHODS
  We included 74 common migraine patients consequently. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire and quality of life of patients was investigated according to MSQ (Migraine-Specific Quality of Life Questionnaire v2.1) questionnaire. Thirty patients with positive family history of migraine were selected and sequencing analysis after DNA extraction was performed.
  
  
  RESULTS
  Direct sequencing revealed a known SNP G to A transition in the exon 16 (nt2369, G → A) in 9 patients. There was no significantly correlation between polymorphism and type of migraine, severity, frequency, duration and quality of life in family positive migraine. Evaluated migraine severity by HIT6 questioner couldn't act as a risk factor for this polymorphism (OR: 0.93, CI%95 0.82-1.06 P = 0.3).
  
  
  CONCLUSIONS
  In Iranian population no significant association was seen between Thr698Thr (nt2369) polymorphism and head pain severity in familial migraine. Confirmation of this hypothesis needs further investigation.
authors: Isfahan Neuroscience Research Center, Isfahan university of Medical Sciences, Isfahan, Iran ; Department of Medical Sciences, Najaf Abad Branch, Isfahan, Iran.
authors: Rokhsareh
authors: R
authors: Meamar
authors: Nafise
authors: N
authors: Soltani
authors: Neda
authors: N
authors: Mohammadi
authors: Maryam
authors: M
authors: Ostadsharif
keywords: Migraine; quality of life; severity; single nucleotide polymorphism
references: J Headache Pain. 2012 Oct;13(7):513-9
references: 22752568
references: Cephalalgia. 2000 Oct;20(8):696-700
references: 11167897
references: J Med Genet. 2001 May;38(5):328-33
references: 11403042
references: Arch Neurol. 2004 Jun;61(6):926-8
references: 15210532
references: Lancet Neurol. 2002 Sep;1(5):285-93
references: 12849426
references: Am J Med Genet A. 2003 Feb 1;116A(4):324-8
references: 12522784
references: Genomics. 1994 Oct;23(3):707-9
references: 7851903
references: Genomics. 2001 Dec;78(3):150-4
references: 11735221
references: Cephalalgia. 1988;8 Suppl 7:1-96
references: 3048700
references: Curr Opin Neurol. 2008 Jun;21(3):331-7
references: 18451718
references: Neurology. 1994 Jun;44(6 Suppl 4):S17-23
references: 8008222
references: Headache. 2012 Mar;52(3):409-21
references: 21929662
references: Hum Genet. 1995 Nov;96(5):604-8
references: 8530012
references: Headache. 1995 Oct;35(9):513-9
references: 8530274
references: Neurogenetics. 2009 Jul;10(3):199-208
references: 19219470
references: Cardiovasc Drugs Ther. 1997 Sep;11(4):603-4
references: 9358966
references: J Pain. 2005 Mar;6(3):159-67
references: 15772909
references: Cell. 1996 Nov 1;87(3):543-52
references: 8898206
references: Am J Med Genet. 1998 Sep 1;79(2):148-51
references: 9741473
references: Neurosci Lett. 2009 Mar 27;453(1):12-5
references: 19429006
references: Headache. 1995 Feb;35(2):70-8
references: 7737864
references: J Neurol Sci. 2012 Dec 15;323(1-2):232-5
references: 23058564