title: A cluster to remember.
abstract: Based on a massive transcription factor location analysis within a single cell type, in this issue Yan et al. find that the great majority of occupancies occur within dense clusters of up to 100 factors that almost invariably contain cohesins. Retention of cohesins at cluster sites during mitosis raises the possibility that they contribute to transcriptional memory during the cell cycle.
authors: Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors: Gerd A
authors: GA
authors: Blobel
authors: Ross C
authors: RC
authors: Hardison
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism*; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D014157:Transcription Factors; D000097722:Cohesins
references: Nature. 2009 Jul 16;460(7253):410-3
references: 19458616
references: Genome Biol. 2009;10(7):R80
references: 19627575
references: PLoS Genet. 2013 Mar;9(3):e1003382
references: 23555293
references: Nature. 2010 Sep 23;467(7314):430-5
references: 20720539
references: Genome Biol. 2012 Sep 26;13(9):R48
references: 22950945
references: Curr Opin Cell Biol. 2013 Jun;25(3):327-33
references: 23465542
references: Cell. 2013 Aug 15;154(4):801-13
references: 23953112
references: Nature. 2012 Sep 6;489(7414):91-100
references: 22955619
references: Cell. 2012 Aug 17;150(4):725-37
references: 22901805
references: Epigenetics Chromatin. 2013 Apr 02;6(1):6
references: 23547918