title: Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner.
abstract: The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of IAV infection on p53 stability and transcriptional activity. Our results indicate that IAV-induced stabilization of p53 only partially correlates with modulation of p53 transcriptional activity measured during infection. Moreover, we show that the viral non-structural protein 1 (NS1) is able to inhibit p53 transcriptional activity, in a promoter-dependent manner. Based on these data, we propose that NS1 may contribute to p53-mediated cell fate decision during IAV infection.
authors: Laboratoire de Virologie et Pathologie Humaine VirPath, Equipe VirCell, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France. olivier.terrier@univ-lyon1.fr
authors: Olivier
authors: O
authors: Terrier
authors: Audrey
authors: A
authors: Diederichs
authors: Julia
authors: J
authors: Dubois
authors: Gaëlle
authors: G
authors: Cartet
authors: Bruno
authors: B
authors: Lina
authors: Jean-Christophe
authors: JC
authors: Bourdon
authors: Manuel
authors: M
authors: Rosa-Calatrava
mesh_terms: D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D004285:Dogs; D054884:Host-Pathogen Interactions; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000378:metabolism*; D061985:Madin Darby Canine Kidney Cells; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D055550:Protein Stability; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C085820:INS1 protein, influenza virus; D016159:Tumor Suppressor Protein p53; D017361:Viral Nonstructural Proteins
keywords: Influenza virus; Non-structural protein NS1; Orthomyxoviridae; Transcription factor; p53