title: Determination of nanostructure of liposomes containing two model drugs by X-ray scattering from a synchrotron source.
abstract: Small-angle X-ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X-ray scattering model, developed for multilamellar liposome systems [Pabst et al. (2000), Phys. Rev. E, 62, 4000-4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and their concentration. Even though the experimental data reveal a complicated picture of the drug-bilayer interaction, they clearly show a correlation between nanostructure, drug and concentration in some aspects. The localization of the drugs in the bilayers is discussed.
authors: Department of Chemistry, Ångström Laboratory, Uppsala University, Lagerhyddsvägen 1, S-75120 Uppsala, Sweden.
authors: Alexandr
authors: A
authors: Nasedkin
authors: Jan
authors: J
authors: Davidsson
authors: Mont
authors: M
authors: Kumpugdee-Vollrath
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D008051:Lipid Bilayers; D008081:Liposomes / Q000737:chemistry*; D008962:Models, Theoretical; D049329:Nanostructures; D010743:Phospholipids / Q000737:chemistry*; D053838:Scattering, Small Angle; D017356:Synchrotrons; D014961:X-Ray Diffraction / Q000379:methods*
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D010743:Phospholipids; D000082:Acetaminophen; D001241:Aspirin
keywords: SAXS; WAXS; acetylsalicylic acid; drug-loaded liposomes; paracetamol