title: The effect of brominated furanones on the formation of Staphylococcus aureus biofilm on PVC.
abstract: To study the influence of brominated furanones on the formation of Staphylococcus aureus (SA) biofilm on PVC thus providing new avenues of research on the surface modification of materials and clinical treatment of biomaterial-centered infection. Three brominated furanones (furanone-1, furanone-2, and furanone-3) were coated on the surface of PVC material. Both the modified PVC materials and SA were co-cultivated together. To assess the thickness of bacterial biofilm and bacterium colony unit area on PVC materials, confocal laser scanning microscopy and scanning electron microscopy (SEM) were used to observe the surface structure of SA biofilm formation. All treatments were compared with the control group which was not coated with furanones. PVC materials coated with furanone-1 had an increase in bacterial biofilm as well as SA colony area when compared with control. However, there was no significant difference between treating with furanone-1 and furanone-3 (P > 0.05). The impact of different brominated furanones on SA biofilm formation on the surface of PVC materials is different, furanone-1 can promote the SA biofilm formation on the surface of PVC material.
authors: Cardiothoracic Surgery Section, The Third Affiliated Hospital of Kunming Medical University (Yunnan Province Cancer Hospital), Lung Cancer Research Center, Yunnan Institute of Oncology, 519 Kun-Zhou Road, Kunming, 650118, Yunnan, China.
authors: Lei
authors: L
authors: Yujie
authors: Xu
authors: X
authors: Geng
authors: Yun-chao
authors: YC
authors: Huang
authors: Yang
authors: Y
authors: Li
authors: Kaiyun
authors: K
authors: Yang
authors: Lianhua
authors: L
authors: Ye
authors: Xiaobo
authors: X
authors: Chen
authors: Guangqiang
authors: G
authors: Zhao
authors: Chen
authors: C
authors: Yin
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D054879:Halogenation; D011143:Polyvinyl Chloride / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000502:physiology*; D013499:Surface Properties
chemical_list: D005663:Furans; D011143:Polyvinyl Chloride; C039281:furan