title: A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose.
abstract: The paper studies the compressibility and disintegration time of tablets from the co-processed dry binder DisintequikTM MCC in combination with two lubricants at two concentrations in dependence on compression force. It also compares identical parameters in the physical mixtures of the spray-dried lactose Flowlac® 100 and the microcrystalline cellulose Microcel® MC-102 in the ratios of 9 : 1, 8 : 2 and 7 : 3, again in combination with two lubricants of two concentrations at one compression force. The lubricants employed are magnesium stearate and poloxamer 407 in concentrations of 1% and 2%. Compressibility is evaluated by means of energy balance of compression and tensile strength of tablets. DisintequikTM MCC shows higher values of total energy of compression due to higher values of the energy accumulated by the tablet, higher plasticity, higher strength and a longer disintegration time of tablets than the physical mixture of spray-dried lactose and microcrystalline cellulose of a corresponding content. .
authors: Department of Pharmaceutical Technology, Charles University in Prague, Hradec Kralove. muzikova@faf.cuni.cz
authors: Jitka
authors: J
authors: Mužíková
authors: Pavla
authors: P
authors: Sináglová
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D054327:Lubricants / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
chemical_list: D005079:Excipients; D054327:Lubricants; D013229:Stearic Acids; D013607:Tablets; D020442:Poloxamer; C031183:stearic acid; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose