title: Kidney and pancreatic extramedullary relapse in adult acute lymphoblastic leukemia: a case report and review of the literature.
abstract: Extramedullary relapse of acute lymphoblastic leukemia (ALL) is rare and has been primarily reported in pediatric patients or hematopoietic stem cell transplant recipients. We report a case of a 62-year-old woman who presented with relapsed ALL involving her kidneys, pancreas, and bone marrow 2 years after completing chemotherapy with a standard ALL protocol. Unfortunately, her extramedullary disease progressed despite treatment. To the best of our knowledge, this is the first reported case of extramedullary relapse of B-cell ALL to the kidneys and pancreas occurring in an adult patient who had not previously undergone a hematopoietic stem cell transplant. A literature review of kidney and pancreatic extramedullary relapse in ALL is also included.
authors: Division of Hematology, Department of Medicine, London Health Sciences Centre, Victoria Hospital, 800 Commissioners Road East, London, ON, Canada N6A 5W9.
authors: Leslie
authors: L
authors: Skeith
authors: Alejandro
authors: A
authors: Lazo-Langner
authors: Joy
authors: J
authors: Mangel
references: Br J Haematol. 2001 Dec;115(3):545-53
references: 11736934
references: An Esp Pediatr. 1991 Feb;34(2):170-2
references: 2042816
references: J Pediatr. 1986 Oct;109(4):665-8
references: 3463724
references: Leuk Lymphoma. 2013 Jul;54(7):1430-6
references: 23167607
references: Cancer. 1998 Apr 1;82(7):1387-95
references: 9529033
references: Acta Paediatr Jpn. 1991 Aug;33(4):540-7
references: 1792914
references: Bone Marrow Transplant. 2010 May;45(5):953-4
references: 19767785
references: Pediatr Radiol. 2002 May;32(5):360-1
references: 11956725
references: Chin Med J (Engl). 2010 Nov;123(22):3364-6
references: 21163148
references: Blood. 2001 Mar 1;97(5):1211-8
references: 11222362
references: Blood. 2007 Dec 1;110(12):4022-9
references: 17720883
references: Blood. 2007 Feb 1;109(3):944-50
references: 17032921
references: Leuk Res. 2010 Jul;34(7):e150-1
references: 20089303
references: J Pediatr. 1994 Oct;125(4):584-6
references: 7931878
references: Haematologica. 2006 May;91(5 Suppl):ECR07
references: 16709515
references: Curr Hematol Malig Rep. 2010 Oct;5(4):185-91
references: 20717757
references: Leukemia. 2008 Dec;22(12):2142-50
references: 18818707
references: Indian J Pathol Microbiol. 2010 Jan-Mar;53(1):155-6
references: 20090251
references: Leuk Lymphoma. 2004 Apr;45(4):825-8
references: 15160965
references: Am J Dis Child. 1978 Dec;132(12):1204-5
references: 281126
references: Rinsho Ketsueki. 2011 Dec;52(12):1882-7
references: 22241156
references: Bone Marrow Transplant. 1995 Apr;15(4):515-21
references: 7655375
references: Clin Nephrol. 1992 Sep;38(3):142-4
references: 1395166
references: Nephrol Dial Transplant. 2003 Jun;18(6):1214-6
references: 12748358
references: Blood. 2007 Oct 1;110(7):2268-75
references: 17596539
references: Blood. 2006 Mar 1;107(5):1761-7
references: 16269611
references: J Pediatr Hematol Oncol. 2010 Mar;32(2):150-1
references: 20048689
references: J Pediatr Hematol Oncol. 2008 Jan;30(1):87-9
references: 18176191
references: Leuk Lymphoma. 2006 Sep;47(9):1754-67
references: 17064985
references: J Pediatr Ophthalmol Strabismus. 2009 Jun 25;:
references: 19645387
references: J Pediatr Hematol Oncol. 2000 Sep-Oct;22(5):454-6
references: 11037860
references: Pediatr Radiol. 2011 Jun;41(6):779-80
references: 21076824
references: Am J Kidney Dis. 2010 Nov;56(5):1001-5
references: 20599308
references: Med Pediatr Oncol. 1990;18(4):283-6
references: 2355888
references: Indian J Pediatr. 2004 Jun;71(6):555-7
references: 15226571
references: Clin Cancer Res. 2013 Jan 15;19(2):357-66
references: 23213054