title: Retinal detachment and proliferative vitreoretinopathy: central retinal artery blood velocities, intraocular pressure, and endothelin 1.
abstract: OBJECTIVE
  To analyze if endothelin 1 may have an effect on central retinal artery (CRA) blood flow velocities and intraocular pressure (IOP) in retinal detachment.
  
  
  METHODS
  Using radioimmunoassay, immunoreactive endothelin 1 levels were tested in both plasma and subretinal fluid specimens from patients with retinal detachment, while only plasma specimens from healthy subjects were tested. Central retinal artery Doppler sonography parameters and IOP were measured in eyes with retinal detachment, with and without proliferative vitreoretinopathy, their respective healthy fellow eyes, and normal eyes.
  
  
  RESULTS
  Retinal detachment eyes had lower CRA peak systolic velocity and end-diastolic velocity, lower IOP, and higher plasma immunoreactive endothelin 1 levels than normal eyes (P < 0.0001). Eyes with proliferative vitreoretinopathy had lower CRA peak systolic velocity and end-diastolic velocity, higher resistivity index, lower IOP, higher plasma immunoreactive endothelin 1 levels, and higher subretinal fluid immunoreactive endothelin 1 than eyes without proliferative vitreoretinopathy (P < 0.0001). A statistically significant linear correlation was found among CRA parameters, IOP, and subretinal fluid immunoreactive endothelin 1 measurements.
  
  
  CONCLUSIONS
  Endothelin 1 has shown a close relationship with IOP and CRA blood flow changes associated to retinal detachment as well as with proliferative vitreoretinopathy complications.
authors: Department of Ophthalmology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain. MRPUCMHS@telefonica.net
authors: Manuela
authors: M
authors: Roldán-Pallarés
authors: Abdalla-Sadiq
authors: AS
authors: Musa
authors: Julian
authors: J
authors: Hernández-Montero
authors: Carmen
authors: C
authors: Bravo-Llatas Sc
authors: Raquel
authors: R
authors: Fernández-Durango
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D012161:Retinal Artery / Q000502:physiology*; D012163:Retinal Detachment / Q000503:physiopathology*; D058471:Subretinal Fluid / Q000378:metabolism; D014065:Tonometry, Ocular; D018615:Ultrasonography, Doppler, Color; D018630:Vitreoretinopathy, Proliferative / Q000503:physiopathology*
chemical_list: D019332:Endothelin-1