title: Extending the tissue penetration capability of conventional photosensitisers: a carbon quantum dot-protoporphyrin IX conjugate for use in two-photon excited photodynamic therapy.
abstract: A carbon quantum dot (CQD)-protoporphyrin (IX) sensitisier conjugate was designed to exploit the large two-photon absorption cross section of CQDs and enable the indirect excitation of the sensitiser with 800 nm irradiation via FRET.
authors: School of Pharmacy and Pharmaceutical Sciences, The University of Ulster, Northern Ireland, BT52 1SA, UK. j.callan@ulster.ac.uk.
authors: Colin
authors: C
authors: Fowley
authors: Nikolitsa
authors: N
authors: Nomikou
authors: Anthony P
authors: AP
authors: McHale
authors: Bridgeen
authors: B
authors: McCaughan
authors: John F
authors: JF
authors: Callan
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D005354:Fibrosarcoma / Q000188:drug therapy; D031541:Fluorescence Resonance Energy Transfer; D006367:HeLa Cells; D006801:Humans; D008027:Light; D051379:Mice; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011524:Protoporphyrins / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*; D014183:Transplantation, Heterologous
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D002244:Carbon; C028025:protoporphyrin IX