title: Incidence, etiology, and outcomes of rhabdomyolysis in a single tertiary referral center.
abstract: We have encountered numerous cases of rhabdomyolysis associated with acute pesticide intoxication; however, the cause, incidence, and treatment outcomes of rhabdomyolysis have not been studied. The current study involved 2,125 patients hospitalized with acute chemical poisoning. Based on clinical and laboratory parameters and treatment outcomes, we found that overall incidence of rhabdomyolysis in our hospital was 0.06% (93 of 143,830 patients admitted), but the incidence associated with acute pesticide intoxication was 1.8% (33 of 1,793 cases). The incidence of rhabdomyolysis after pesticide intoxication was significantly higher in men than in women (P = 0.010). The amount of pesticide ingested was significantly higher in rhabdomyolysis patients than that in those who did not develop rhabdomyolysis (mean ± SD, 114.1 ± 79.5 mL vs 74.1 ± 94.2 mL, P = 0.010). Our results show that pesticide intoxication is a frequent cause of rhabdomyolysis and is more common among men than women. The volume of pesticide ingested, and not the degree of human toxicity, is the main factor influencing the incidence of rhabdomyolysis.
authors: Department of Internal Medicine, Soonchunhyang University, College of Medicine, Cheonan, Korea.
authors: Jae-Seok
authors: JS
authors: Park
authors: Min-Sook
authors: MS
authors: Seo
authors: Hyo-Wook
authors: HW
authors: Gil
authors: Jong-Oh
authors: JO
authors: Yang
authors: Eun-Young
authors: EY
authors: Lee
authors: Sae-Yong
authors: SY
authors: Hong
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000506:poisoning; D012206:Rhabdomyolysis / Q000453:epidemiology* / Q000209:etiology; D012737:Sex Factors; D062606:Tertiary Care Centers; D016896:Treatment Outcome
chemical_list: D010575:Pesticides
keywords: Acute Kidney Injury; Intoxication; Pesticides; Rhabdomyolysis; Surfactant
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