title: Tracking pulmonary gas exchange by breathing control during exercise: role of muscle blood flow.
abstract: Populations of group III and IV muscle afferent fibres located in the adventitia of the small vessels appear to respond to the level of venular distension and to recruitment of the vascular bed within the skeletal muscles. The CNS could thus be informed on the level of muscle hyperaemia when the metabolic rate varies. As a result, the magnitude and kinetics of the change in peripheral gas exchange - which translates into pulmonary gas exchange - can be sensed. We present the view that the respiratory control system uses these sources of information of vascular origin, among the numerous inputs produced by exercise, as a marker of the metabolic strain imposed on the circulatory and the ventilatory systems, resulting in an apparent matching between pulmonary gas exchange and alveolar ventilation.
authors: Pennsylvania State University College of Medicine, Department of Medicine, 500 University Drive, H041, Hershey, PA 17033, USA. phaouzi@hmc.psu.edu.
authors: Philippe
authors: P
authors: Haouzi
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000294:innervation / Q000502:physiology; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012119:Respiration
references: Acta Neurobiol Exp (Wars). 1975;35(3):227-40
references: 1163305
references: Chest. 1992 Mar;101(3):656-61
references: 1541128
references: J Appl Physiol (1985). 2011 Mar;110(3):854-6
references: 21030668
references: J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul;53(1):218-24
references: 7118635
references: J Anat. 1969 Sep;105(Pt 2):231-54
references: 5802932
references: Physiol Rev. 1974 Jan;54(1):75-159
references: 4587247
references: J Appl Physiol (1985). 2001 May;90(5):1798-810
references: 11299270
references: J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1506-13
references: 6809716
references: Circ Res. 1987 Oct;61(4 Pt 2):I60-5
references: 3652404
references: J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):45-54
references: 6782057
references: Compr Physiol. 2012 Jan;2(1):743-77
references: 23728984
references: Med Sci Sports Exerc. 1994 Mar;26(3):319-27
references: 8183096
references: Brain Res. 1976 Aug 20;113(1):201-5
references: 133748
references: Respir Physiol Neurobiol. 2006 Apr 28;151(2-3):267-79
references: 16412707
references: J Physiol. 1988 Feb;396:365-77
references: 3137328
references: Respir Physiol. 1993 Nov;94(2):137-50
references: 8272586
references: J Appl Physiol Respir Environ Exerc Physiol. 1978 Jul;45(1):109-14
references: 670022
references: Chest. 1978 Feb;73(2 Suppl):274-7
references: 23261
references: Respir Physiol. 1996 Aug;105(1-2):143-53
references: 8897660
references: Respir Physiol. 1990 May-Jun;80(2-3):155-62
references: 2218097
references: J Appl Physiol (1985). 1999 Aug;87(2):545-53
references: 10444611
references: Respir Physiol Neurobiol. 2007 Nov 15;159(2):211-8
references: 17869591
references: J Physiol. 1972 Jul;224(1):173-86
references: 5039977
references: Am J Physiol. 1999 Dec;277(6 Pt 2):S244-59
references: 10644251
references: J Physiol. 1989 Dec;419:1-14
references: 2621624
references: J Appl Physiol. 1957 May;10(3):367-71
references: 13438785
references: J Appl Physiol (1985). 1990 Aug;69(2):718-27
references: 2228882
references: J Appl Physiol (1985). 2004 Feb;96(2):407-18
references: 14715672
references: J Appl Physiol (1985). 1990 Aug;69(2):407-18
references: 2228848
references: Med Sci Sports Exerc. 1990 Apr;22(2):141-54
references: 2192221
references: Respir Physiol Neurobiol. 2012 Apr 30;181(2):220-7
references: 22465526
references: J Physiol. 1983 Sep;342:383-97
references: 6631740
references: Adv Exp Med Biol. 1998;450:195-7
references: 10026983
references: J Appl Physiol. 1973 Jul;35(1):68-76
references: 4716163
references: J Appl Physiol (1985). 2009 Mar;106(3):904-10
references: 19095753
references: Respir Physiol Neurobiol. 2009 May 30;167(1):101-6
references: 18824145
references: J Appl Physiol. 1973 Jul;35(1):58-67
references: 4716162
references: Rev Fr Etud Clin Biol. 1958 Sep;3(7):755-61
references: 13591867
references: J Physiol. 2001 Jun 15;533(Pt 3):823-36
references: 11410638
references: J Appl Physiol Respir Environ Exerc Physiol. 1984 May;56(5):1335-9
references: 6427152
references: J Appl Physiol (1985). 2003 May;94(5):1726-34
references: 12533504
references: Br J Sports Med. 1998 Sep;32(3):199-211
references: 9773167
references: Respir Physiol. 1997 Feb;107(2):181-90
references: 9108632
references: Prog Brain Res. 1996;113:83-100
references: 9009729
references: J Physiol (Paris). 1959 Mar-Apr;51(2):163-261
references: 13655208
references: Respir Physiol. 1993 Mar;91(2-3):207-26
references: 8469845
references: J Appl Physiol Respir Environ Exerc Physiol. 1977 Feb;42(2):300-1
references: 838654
references: Adv Exp Med Biol. 2002;508:25-32
references: 12171119
references: J Physiol. 2004 Aug 15;559(Pt 1):315-25
references: 15235099
references: J Appl Physiol (1985). 2010 Oct;109(4):966-76
references: 20634355
references: Exp Brain Res. 1978 Apr 14;31(4):511-22
references: 658178
references: Respir Physiol Neurobiol. 2007 Jan 15;155(1):29-34
references: 16621736
references: Circulation. 1968 Nov;38(5 Suppl):VII1-78
references: 5696236