title: Sex differences between cT4b and pT4b rectal cancers.
abstract: We retrospectively evaluated rectal cancer surgery cases in which resection had been performed for invasion of other organs in terms of pathologic findings from the viewpoint of sex differences. We enrolled 61 consecutive patients with rectal cancer who had undergone curative surgery with resection of invaded adjacent organs. We investigated invasion of adjacent organs in terms of pathologic findings according to sex differences. Among males, 4 cases (13.8%) had received combined radical resections of more than 2 organs, while the number of such female cases was 15 (46.9%). The difference between males and females was statistically significant (P = 0.006). Among male cases, histopathologic invasion was present in 4 (13.8%), while 9 female cases (28.1%) showed this feature. Nevertheless, there was not a statistically significant difference between males and females (P = 0.08); the rate in females was roughly twice that in males. No significant difference was recognized in the overall survival rates between males and females, but more females than males experienced local recurrence. In cases with rectal cancer invading neighboring organs, the effect of the invasion must be carefully determined, and the most appropriate operative approach selected accordingly.
authors: Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
authors: Koji
authors: K
authors: Komori
authors: Kenya
authors: K
authors: Kimura
authors: Takashi
authors: T
authors: Kinoshita
authors: Tsuyoshi
authors: T
authors: Sano
authors: Seiji
authors: S
authors: Ito
authors: Tetsuya
authors: T
authors: Abe
authors: Yoshiki
authors: Y
authors: Senda
authors: Kazunari
authors: K
authors: Misawa
authors: Yuichi
authors: Y
authors: Ito
authors: Norihisa
authors: N
authors: Uemura
authors: Yasuhiro
authors: Y
authors: Shimizu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012737:Sex Factors
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