title: Steroid regulation of C. elegans diapause, developmental timing, and longevity.
abstract: Hormones play a critical role in driving major stage transitions and developmental timing events in many species. In the nematode C. elegans the steroid hormone receptor, DAF-12, works at the confluence of pathways regulating developmental timing, stage specification, and longevity. DAF-12 couples environmental and physiologic signals to life history regulation, and it is embedded in a rich architecture governing diverse processes. Here, we highlight the molecular insights, extraordinary circuitry, and signaling pathways governing life stage transitions in the worm and how they have yielded fundamental insights into steroid regulation of biological time.
authors: Max Planck Institute for Biology of Ageing, Cologne, Germany. AAntebi@age.mpg.de
authors: Adam
authors: A
authors: Antebi
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development*; D029742:Caenorhabditis elegans Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D008018:Life Cycle Stages / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D008954:Models, Biological; D015394:Molecular Structure; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; C410905:DAF-12 protein, C elegans; D012739:Gonadal Steroid Hormones; D018160:Receptors, Cytoplasmic and Nuclear
keywords: Aging; Developmental timing; Diapause; Heterochronic; Insulin; MicroRNA; Steroid