title: Nutrient regulation of immunity: O-GlcNAcylation regulates stimulus-specific NF-κB-dependent transcription.
abstract: Nutrients regulate gene transcription by the dynamic cycling of O-linked N-acetylglucosamine (O-GlcNAc) on proteins that constitute the transcriptional machinery. A study shows that O-GlcNAcylation of the nuclear factor κB (NF-κB) subunit c-Rel is required for its binding to the promoters of some, but not all, key T cell receptor-dependent genes; however, O-GlcNAcylation is dispensable for the binding of c-Rel to the promoters of tumor necrosis factor-α-dependent genes. This study not only illustrates how specific stimuli that act on the same transcription factor can elicit the expression of particular sets of genes, it also suggests a possible mechanism for autoimmunity in diabetes.
authors: Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. gwhart@jhmi.edu
authors: Gerald W
authors: GW
authors: Hart
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000215:Acylation; D004032:Diet; D005786:Gene Expression Regulation; D006801:Humans; D007109:Immunity / Q000235:genetics; D008957:Models, Genetic; D016328:NF-kappa B / Q000378:metabolism*; D009747:Nutritional Physiological Phenomena / Q000235:genetics / Q000276:immunology; D011401:Promoter Regions, Genetic / Q000235:genetics; D011485:Protein Binding; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: D016328:NF-kappa B; D000117:Acetylglucosamine