title: A lower serum level of middle-molecular-weight adiponectin is a risk factor for endometrial cancer.
abstract: BACKGROUND
  The present study was undertaken to examine the correlation between serum levels of adiponectin isoforms and the risk for endometrial cancer.
  
  
  METHODS
  This retrospective case-control study included 43 Japanese women with endometrial cancer and 62 Japanese women with no history of cancer. Serum levels of total adiponectin and the respective isoforms were determined by enzyme-linked immunosorbent assay. Multivariate logistic regression analysis was performed on the serum levels of total adiponectin and its isoforms, high molecular weight, middle molecular weight, and low molecular weight adiponectins, after adjustment for confounders (age, body mass index, hypertension, and diabetes mellitus).
  
  
  RESULTS
  The distribution of body mass index revealed a statistically significant difference between patients and controls (P = 0.001). A statistically significant difference (P < 0.01) was also found in the incidence of diabetes mellitus between the two groups, although there was no significant difference in the incidence of hypertension. In controls, an inverse correlation was observed between body mass index and serum adiponectin levels. However, in patients, an inverse correlation was found only between body mass index and serum middle molecular weight adiponectin level. After adjustment for confounding variables, the factor found to be most closely associated with endometrial cancer was a lower serum level of middle molecular weight adiponectin (adjusted odds ratio 4.89, 95 % confidence interval value 1.25-19.11, P = 0.022).
  
  
  CONCLUSIONS
  Low serum level of middle molecular weight adiponectin was the only independent risk factor for endometrial cancer suggesting that the application of adiponectin might prevent or decrease the risk for endometrial cancer.
authors: Department of Gynecology and Obstetrics, Funabashi Municipal Medical Center, Chiba, Japan.
authors: Yukari
authors: Y
authors: Ohbuchi
authors: Yasunobu
authors: Y
authors: Suzuki
authors: Ikuo
authors: I
authors: Hatakeyama
authors: Yoshifumi
authors: Y
authors: Nakao
authors: Atsuya
authors: A
authors: Fujito
authors: Tsuyoshi
authors: T
authors: Iwasaka
authors: Keiichi
authors: K
authors: Isaka
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D011379:Prognosis; D020033:Protein Isoforms / Q000097:blood*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D020033:Protein Isoforms
references: Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):466-72
references: 15701829
references: Diabetes Care. 2006 Jun;29(6):1357-62
references: 16732021
references: J Biochem. 1996 Oct;120(4):803-12
references: 8947845
references: J Clin Endocrinol Metab. 2004 Mar;89(3):1160-3
references: 15001602
references: J Biol Chem. 2002 Jul 19;277(29):25863-6
references: 12032136
references: J Biol Chem. 2003 Oct 10;278(41):40352-63
references: 12878598
references: J Clin Endocrinol Metab. 2004 Mar;89(3):1102-7
references: 15001594
references: Cancer Sci. 2007 Jul;98(7):1120-7
references: 17459059
references: Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2476-81
references: 14983034
references: Biochem Biophys Res Commun. 2004 Apr 9;316(3):924-9
references: 15033490
references: J Clin Endocrinol Metab. 2003 Mar;88(3):993-7
references: 12629074
references: J Clin Endocrinol Metab. 2007 May;92(5):1821-6
references: 17341566
references: Clin Chem Lab Med. 2006;44(10):1264-8
references: 17032140
references: Blood. 2000 Sep 1;96(5):1723-32
references: 10961870
references: Circulation. 2003 Feb 11;107(5):671-4
references: 12578865
references: Gastroenterology. 2003 Dec;125(6):1796-807
references: 14724832
references: Circulation. 2002 Nov 26;106(22):2767-70
references: 12451000
references: J Biol Chem. 2003 Mar 14;278(11):9073-85
references: 12496257
references: Clin Endocrinol (Oxf). 2007 Aug;67(2):276-81
references: 17547685
references: Am J Cardiol. 2007 Aug 15;100(4):569-74
references: 17697807
references: Diabetes. 2005 Dec;54(12):3358-70
references: 16306350
references: J Biol Chem. 2003 Jan 24;278(4):2461-8
references: 12431986
references: J Biol Chem. 1995 Nov 10;270(45):26746-9
references: 7592907
references: Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5
references: 15369797
references: J Endocrinol Invest. 2006 Mar;29(3):231-6
references: 16682836
references: Lancet. 2002 Jul 6;360(9326):57-8
references: 12114044
references: J Clin Endocrinol Metab. 2001 May;86(5):1930-5
references: 11344187
references: J Biol Chem. 2003 Dec 12;278(50):50810-7
references: 14522956
references: J Natl Cancer Inst. 2005 Nov 16;97(22):1688-94
references: 16288122
references: Nat Med. 2002 Nov;8(11):1288-95
references: 12368907
references: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10
references: 11172066
references: Circ Res. 2004 Mar 5;94(4):e27-31
references: 14752031
references: Br J Cancer. 2006 May 8;94(9):1221-5
references: 16570048
references: Nat Med. 2001 Aug;7(8):941-6
references: 11479627
references: Biochem Biophys Res Commun. 1996 Apr 16;221(2):286-9
references: 8619847
references: Cancer. 2006 Jun 1;106(11):2376-81
references: 16639730
references: J Biol Chem. 1996 May 3;271(18):10697-703
references: 8631877