title: Should Finasteride Be Routinely Given Preoperatively for TURP?
abstract: Objective. The aim of the review was to compare the use of finasteride to placebo in patients undergoing TURP procedures. Material & Methods. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966-November 2011), EMBASE (1980-November 2011), CINAHL, Clinicaltrials.gov, Google Scholar, reference lists of articles, and abstracts from conference proceedings without language restriction for studies comparing finasteride to placebo patients needing TURPs. Results. Four randomised controlled trials were included comparing finasteride to a placebo. A meta-analysis was not conducted due to the disparity present in the results between the studies. Three of the studies found that finasteride could reduce either intra- or postoperative bleeding after TURP. One study found finasteride to significantly lower the microvessel density (MVD) and vascular endothelial growth factor (VEGF). None of the studies reported any long-term complications related to either the medication or the procedure. Conclusion. finasteride reduces bleeding either during or after TURP.
authors: Department of Urology, University Hospital of Wales, Cardiff CF14 4XW, UK.
authors: O M
authors: OM
authors: Aboumarzouk
authors: M Z
authors: MZ
authors: Aslam
authors: A
authors: A
authors: Wedderburn
authors: K
authors: K
authors: Turner
authors: O
authors: O
authors: Hughes
authors: H G
authors: HG
authors: Kynaston
references: J Urol. 2000 Feb;163(2):496-8
references: 10647664
references: Prostate Cancer Prostatic Dis. 2005;8(3):215-8
references: 15999118
references: BJU Int. 2007 Mar;99(3):587-94
references: 17407516
references: BJU Int. 2005 Dec;96(9):1319-22
references: 16287453
references: J Urol. 2002 Nov;168(5):2024-6
references: 12394700
references: Actas Urol Esp. 2010 Nov;34(10):866-9
references: 21159282
references: J Urol. 1989 Feb;141(2):243-7
references: 2643719
references: J Urol. 1995 Nov;154(5):1779-82
references: 7563345
references: BJU Int. 2004 Jan;93(1):3-4
references: 14678355
references: Urology. 2000 May;55(5):684-9
references: 10792079
references: Prostate. 2006 Aug 1;66(11):1194-202
references: 16652387
references: Urology. 2001 Dec;58(6):972-6
references: 11744471
references: J Urol. 2011 May;185(5):1793-803
references: 21420124
references: J Clin Endocrinol Metab. 1992 Mar;74(3):505-8
references: 1371291
references: Scand J Urol Nephrol. 2002;36(3):182-7
references: 12201932
references: Nat Rev Urol. 2011 Aug 16;8(9):504-14
references: 21844906
references: J Urol. 2003 Jan;169(1):20-3
references: 12478093