title: Blood and milk oxidative status after administration of different antioxidants during early postpartum in dairy cows.
abstract: This paper describes serum and milk oxidative profiles during early postpartum (10th-16th day) of dairy cows, after three different treatments: β-carotene and α-tocopherol (Dalmavital®, Fatro, Italy) (VAE Group); L-carnitine, d, L-acetylmethionine, cyanocobalamin (Adiuxan®, Ceva Vetem, Italy) (LCAR Group) and Dalmavital®+Adiuxan® (VAE/LCAR Group). Antioxidant administrations resulted in a general reduction in ROS concentrations which decreased more after a single drug administration (VAE and LCAR Groups) vitamin A and E serum levels increased in the three treated groups compared to control one (p < 0.05). Milk lipoperoxide content was statistically lower in treated cows than in control ones, whereas, as to vitamins, only vitamin E increased in all the treated groups compared to control. Taken together, the results of this study confirm the efficacy of antioxidant administration in the early postpartum of dairy cows and suggest that an excess in antioxidant administration may result, paradoxically, in an increase in ROS generation.
authors: Department of Emergency and Organ Transplantation, University of Bari "Aldo Moro", strada prov.le per Casamassima km3, 70010 Valenzano, BA, Italy.
authors: A
authors: A
authors: Rizzo
authors: M
authors: M
authors: Pantaleo
authors: M
authors: M
authors: Mutinati
authors: G
authors: G
authors: Minoia
authors: C
authors: C
authors: Trisolini
authors: E
authors: E
authors: Ceci
authors: R L
authors: RL
authors: Sciorsci
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002331:Carnitine / Q000494:pharmacology; D002417:Cattle / Q000097:blood / Q000378:metabolism; D005260:Female; D008054:Lipid Peroxides / Q000032:analysis; D008715:Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D008892:Milk / Q000737:chemistry* / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D049590:Postpartum Period / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000032:analysis / Q000097:blood; D014801:Vitamin A / Q000032:analysis / Q000097:blood; D014805:Vitamin B 12 / Q000494:pharmacology; D014810:Vitamin E / Q000032:analysis / Q000097:blood; D024502:alpha-Tocopherol / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; C006379:N-acetylmethionine; D008715:Methionine; D024502:alpha-Tocopherol; D014805:Vitamin B 12; D002331:Carnitine
keywords: Antioxidants; Dairy cow; Early postpartum; NEBAL; Oxidative stress