title: Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma.
abstract: Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial-mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future.
authors: Department of Head and Neck Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
authors: Xionghui
authors: X
authors: Mao
authors: Susheng
authors: S
authors: Miao
authors: Hongjiang
authors: H
authors: He
authors: Suping
authors: S
authors: Miao
authors: Rong
authors: R
authors: Pei
authors: Xianguang
authors: X
authors: Yang
authors: Chen
authors: C
authors: Xiu
authors: Kaibin
authors: K
authors: Song
authors: Jian
authors: J
authors: Zhang
authors: Ji
authors: J
authors: Sun
authors: Shenshan
authors: S
authors: Jia
authors: Qiang
authors: Q
authors: Guan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D015870:Gene Expression; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D000099200:Scaffold Protein ILK
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D051741:Kruppel-Like Transcription Factors; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK; C492214:KLF5 protein, human
references: Recent Results Cancer Res. 1984;95:1-23
references: 6396753
references: J Cancer Res Clin Oncol. 2008 Feb;134(2):163-7
references: 17622557
references: Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6653-8
references: 16617118
references: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 May;41(5):390-1
references: 16850547
references: Cancer Res. 2007 Apr 1;67(7):3450-60
references: 17409456
references: Gastroenterology. 2008 Jan;134(1):120-30
references: 18054006
references: Oncogene. 2009 Oct 22;28(42):3702-13
references: 19668233
references: J Clin Invest. 2005 Feb;115(2):339-47
references: 15668738
references: FEBS Lett. 2005 Aug 29;579(21):4757-62
references: 16102754
references: Cell Metab. 2005 Jan;1(1):27-39
references: 16054042
references: Br J Cancer. 2002 Mar 18;86(6):886-92
references: 11953819
references: Am J Pathol. 2003 Apr;162(4):1283-91
references: 12651620
references: Cancer Res. 1999 Nov 15;59(22):5830-5
references: 10582706
references: Clin Exp Metastasis. 2007;24(8):587-97
references: 17978854
references: Diagn Pathol. 2013 Jul 09;8:114
references: 23837653
references: Mol Ther. 2007 Jan;15(1):94-102
references: 17164780
references: Tumour Biol. 2012 Feb;33(1):149-55
references: 22081375
references: Br J Cancer. 1996 May;73(10):1233-6
references: 8630284
references: J Biol Chem. 2004 Mar 26;279(13):12093-101
references: 14726538
references: Curr Opin Cell Biol. 2003 Dec;15(6):740-6
references: 14644200
references: Int J Biol Macromol. 2013 Oct;61:97-101
references: 23831383
references: J Genet Genomics. 2013 Jun 20;40(6):315-8
references: 23790631
references: PLoS One. 2013 Jun 05;8(6):e65538
references: 23755247
references: Clin Cancer Res. 2007 Nov 1;13(21):6459-68
references: 17975158
references: Hum Pathol. 2013 Oct;44(10):1973-81
references: 23845467
references: Nucleic Acids Res. 2006 Feb 25;34(4):1216-23
references: 16500892
references: Tumour Biol. 2012 Feb;33(1):183-94
references: 22081310
references: Mech Dev. 2003 Nov;120(11):1351-83
references: 14623443
references: Carcinogenesis. 2005 Jul;26(7):1224-32
references: 15760917
references: Cancer Res. 2002 Mar 15;62(6):1613-8
references: 11912130
references: Int J Cancer. 2006 Mar 15;118(6):1346-55
references: 16184550
references: J BUON. 2012 Oct-Dec;17(4):700-5
references: 23335528
references: Int J Biol Macromol. 2013 Sep;60:235-40
references: 23748010
references: J Pathol. 2007 Apr;211(5):532-540
references: 17334981