title: Probiotics as additives on therapy in allergic airway diseases: a systematic review of benefits and risks.
abstract: BACKGROUND
  We conducted a systematic review to find out the role of probiotics in treatment of allergic airway diseases.
  
  
  METHODS
  A comprehensive search of the major electronic databases was done till March 2013. Trials comparing the effect of probiotics versus placebo were included. A predefined set of outcome measures were assessed. Continuous data were expressed as standardized mean difference with 95% CI. Dichotomous data were expressed as odds ratio with 95% CI. P value < 0.05 was considered as significant.
  
  
  RESULTS
  A total of 12 studies were included. Probiotic intake was associated with a significantly improved quality of life score in patients with allergic rhinitis (SMD -1.9 (95% CI -3.62, -0.19); P = 0.03), though there was a high degree of heterogeneity. No improvement in quality of life score was noted in asthmatics. Probiotic intake also improved the following parameters: longer time free from episodes of asthma and rhinitis and decrease in the number of episodes of rhinitis per year. Adverse events were not significant.
  
  
  CONCLUSIONS
  As the current evidence was generated from few trials with high degree of heterogeneity, routine use of probiotics as an additive on therapy in subjects with allergic airway diseases cannot be recommended.
authors: Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar 751019, India. dr_rashmipgi@yahoo.com
authors: Rashmi Ranjan
authors: RR
authors: Das
authors: Sushree Samiksha
authors: SS
authors: Naik
authors: Meenu
authors: M
authors: Singh
mesh_terms: D016208:Databases, Factual; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D046650:Medical Subject Headings; D019936:Probiotics / Q000008:administration & dosage*; D011788:Quality of Life; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000473:pathology; D018570:Risk Assessment
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