title: Flexible access to conformationally-locked bicyclic morpholines.
abstract: A preparatively accessible route to a series of conformationally-locked bicyclic morpholines has been developed. This flexible approach allows for diversification in order for a small array of lead-like scaffolds to be synthesised from readily available key building blocks.
authors: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, Scotland, UK. w.kerr@strath.ac.uk.
authors: Rachael
authors: R
authors: Bogacki
authors: Duncan M
authors: DM
authors: Gill
authors: William J
authors: WJ
authors: Kerr
authors: Scott
authors: S
authors: Lamont
authors: John A
authors: JA
authors: Parkinson
authors: Laura C
authors: LC
authors: Paterson
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D009025:Morpholines; C495809:bispidine