title: Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss.
abstract: OBJECTIVE
  To assess the impact of subclinical hypothyroidism (SCH) in women with recurrent early pregnancy loss (REPL).
  
  
  METHODS
  Observational cohort study.
  
  
  METHODS
  REPL program in an academic medical center.
  
  
  METHODS
  286 women with a history of ≥2 pregnancy losses <10 weeks.
  
  
  METHODS
  From 2004-2007, no treatment for women with SCH (thyroid-stimulating hormone [TSH] >2.5 mIU/L with a normal free thyroxine or free thyroxine index); from 2008 onward, levothyroxine treatment prepregnancy to maintain TSH ≤2.5 mIU/L.
  
  
  METHODS
  Live-birth rate (LBR).
  
  
  RESULTS
  The prevalence of SCH was 55 (19%) of 286 in this REPL cohort. The cumulative LBR was 27 (69%) of 39 for women with SCH versus 104 (74%) of 141 for euthyroid women. The per-pregnancy LBR was 34 (49%) of 69 for SCH versus 129 (58%) of 221 for euthyroid women. When the LBR was compared between treated and untreated SCH, the cumulative LBR was 17 (71%) of 24 versus 10 (67%) of 15, respectively. The per-pregnancy LBR for SCH treated versus untreated women was 22 (48%) of 46 versus 12 (52%) of 23, respectively.
  
  
  CONCLUSIONS
  Although there was a high prevalence of SCH in the REPL cohort, there was no statistically significant difference in the subsequent live-birth rate when comparing women with SCH and euthyroid women, or treated and untreated SCH.
authors: University of Chicago Recurrent Pregnancy Loss Program, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois; Department of Obstetrics and Gynecology, University of Illinois, Chicago, Illinois.
authors: Lia A
authors: LA
authors: Bernardi
authors: Ronald N
authors: RN
authors: Cohen
authors: Mary D
authors: MD
authors: Stephenson
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology; D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000046:Academic Medical Centers; D000328:Adult; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002641:Chicago / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D050498:Live Birth; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013972:Thyrotropin; D013974:Thyroxine
keywords: Euthyroid; pregnancy; recurrent miscarriage; recurrent pregnancy loss; subclinical hypothyroidism