title: Nucleocytoplasmic shuttling of viral proteins in borna disease virus infection.
abstract: Nuclear import and export of viral RNA and proteins are critical to the replication cycle of viruses that replicate in the nucleus. Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that belongs to the order Mononegavirales. BDV has several distinguishing features, one of the most striking being the site of its replication. BDV RNA is transcribed and replicated in the nucleus, while most other negative-strand RNA viruses replicate in the cytoplasm. Therefore, the nucleocytoplasmic trafficking of BDV macromolecules plays a key role in virus replication. Growing evidence indicates that several BDV proteins, including the nucleoprotein, phosphoprotein, protein X and large protein, contribute to the nucleocytoplasmic trafficking of BDV ribonucleoprotein (RNP). The directional control of BDV RNP trafficking is likely determined by the ratios of and interactions between the nuclear localization signals and nuclear export signals in the RNP. In this review, we present a comprehensive view of several unique mechanisms that BDV has developed to control its RNP trafficking and discuss the significance of BDV RNP trafficking in the replication cycle of BDV.
authors: Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan. thonda@virus.kyoto-u.ac.jp
authors: Tomoyuki
authors: T
authors: Honda
authors: Keizo
authors: K
authors: Tomonaga
mesh_terms: D001891:Borna disease virus / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism* / Q000821:virology*; D003593:Cytoplasm / Q000378:metabolism* / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D021381:Protein Transport; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D014764:Viral Proteins
references: J Virol. 2003 Jul;77(14):8099-107
references: 12829848
references: J Virol. 1998 Jan;72(1):783-8
references: 9420287
references: J Gen Virol. 1998 Dec;79 ( Pt 12):2957-63
references: 9880009
references: Microbes Infect. 2009 Mar;11(3):394-402
references: 19397879
references: Vaccine. 2012 Dec 7;30(51):7353-8
references: 22652398
references: Behav Brain Res. 1999 Apr;100(1-2):43-50
references: 10212052
references: Curr Top Microbiol Immunol. 2001;253:157-77
references: 11417134
references: Proc Natl Acad Sci U S A. 1994 May 10;91(10):4362-6
references: 8183914
references: Virology. 1998 Mar 30;243(1):188-97
references: 9527928
references: J Virol. 2001 Apr;75(7):3404-12
references: 11238866
references: J Biol Chem. 2002 Apr 5;277(14):12151-7
references: 11796712
references: J Biol Chem. 1998 Apr 10;273(15):9007-12
references: 9535888
references: J Virol. 2001 Dec;75(24):12098-104
references: 11711600
references: Structure. 2003 Oct;11(10):1219-26
references: 14527390
references: J Virol. 1997 Jul;71(7):5133-9
references: 9188580
references: Cell Host Microbe. 2012 May 17;11(5):492-503
references: 22607802
references: J Virol. 2007 Jan;81(2):743-9
references: 17079312
references: Cell. 1999 Dec 23;99(7):677-90
references: 10619422
references: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3710-5
references: 19237566
references: Virology. 1998 Jun 20;246(1):1-23
references: 9656989
references: J Virol. 2002 Aug;76(16):8460-7
references: 12134049
references: Virus Res. 2005 Aug;111(2):148-60
references: 15992626
references: J Virol. 1998 Dec;72(12):9755-62
references: 9811710
references: J Biol Chem. 2004 Dec 31;279(53):55290-6
references: 15509569
references: Microbes Infect. 2002 Apr;4(4):491-500
references: 11932200
references: J Biol Chem. 1997 Aug 29;272(35):21818-23
references: 9268312
references: J Virol. 1998 May;72(5):4274-80
references: 9557717
references: J Gen Virol. 2004 Jul;85(Pt 7):1895-1898
references: 15218174
references: J Virol. 2011 May;85(9):4567-71
references: 21325425
references: J Virol. 2004 Sep;78(17):9568-72
references: 15308750
references: J Gen Virol. 1999 Jan;80 ( Pt 1):97-100
references: 9934690
references: PLoS One. 2008;3(12):e3904
references: 19066626
references: J Virol. 2000 May;74(9):4425-8
references: 10756058
references: Microbiol Immunol. 2000;44(9):765-72
references: 11092240
references: J Virol. 2000 Apr;74(7):3413-7
references: 10708460
references: J Virol. 2006 Feb;80(3):1121-9
references: 16414989
references: J Virol. 2000 Feb;74(4):1781-6
references: 10644350
references: Proteomics. 2005 Nov;5(17):4483-7
references: 16206331
references: J Gen Virol. 2000 Apr;81(Pt 4):939-47
references: 10725419
references: J Gen Virol. 2011 Aug;92(Pt 8):1859-1869
references: 21562121
references: J Virol. 2003 Nov;77(21):11781-9
references: 14557662
references: PLoS Pathog. 2009 Nov;5(11):e1000654
references: 19893625
references: J Virol. 2007 Jul;81(13):7297-9
references: 17428855
references: J Virol. 2007 Jun;81(11):5497-507
references: 17376920
references: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8969-74
references: 12857949
references: Arch Virol. 2004 Jul;149(7):1409-14
references: 15221540
references: J Gen Virol. 2003 Nov;84(Pt 11):3099-3104
references: 14573815
references: J Virol. 2003 Nov;77(22):12222-31
references: 14581559
references: J Virol. 2009 Dec;83(23):12622-5
references: 19776128
references: Biochim Biophys Acta. 2011 Dec;1813(12):2176-90
references: 21530593