title: Effects of a selective cyclooxygenase-2 inhibitor (celecoxib) on fracture healing in rats.
abstract: BACKGROUND
  Several studies suggested that celecoxib interferes with bone healing while others contradict these findings. This study was conducted to investigate the effects of celecoxib on bone healing in rats femur mold with a dose based on body surface area conversion.
  
  
  METHODS
  72 adult female Sprague Dawley rats were randomly divided into three groups after the internal fixation operation of nondisplaced transverse mid diaphyseal fractures of the right femurs. Each group was treated with 1% methylcellulose, celecoxib (21 mg/kg/d) for 1 week, or celecoxib (21 mg/kg/d) for 4 weeks after surgeries respectively. Bone healing scores and callus formation were evaluated by radiographs at 3, 4, 6 weeks after surgeries. Half of these rats were sacrificed for histological analysis at 4 weeks after surgery. The remaining fractured femurs were evaluated by biomechanical tests at 6 weeks after surgery.
  
  
  RESULTS
  The mean radiographic scores for fracture healing of both short and long term groups were lower than that of the control group and the differences among the three groups were statistically significant (P < 0.05) at 3, 4, 6 weeks after surgery. The mean bone trabecula density of both groups was smaller than that of the control group and the differences were also statistically significant (P < 0.05) at 4 week. The maximum load, total energy and stiffness in both the short term and long term groups were significantly decreased compared with those in the control group (P < 0.05) at 6 week.
  
  
  CONCLUSIONS
  Both short term and long term sustained use of celecoxib in rat models has significantly inhibitory effects on rat fracture healing.
authors: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
authors: Kang-Hua
authors: KH
authors: Li
authors: Liang
authors: L
authors: Cheng
authors: Yong
authors: Y
authors: Zhu
authors: Guo-Bing
authors: GB
authors: Deng
authors: Hai-Tao
authors: HT
authors: Long
keywords: Celecoxib; cyclooxygenase-2 inhibitors; fracture healing; prostaglandins
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