title: Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect.
abstract: OBJECTIVE
  Nitric oxide (NO) plays a crucial role in vascular tone regulation and is involved in pathogenesis of periodontitis. In this cross-sectional study, we investigated the serum and saliva levels of NO metabolites in periodontal disease and their relationship with serum C-reactive protein (CRP) levels, lipids metabolism and periodontal disease severity.
  
  
  METHODS
  Serum and saliva were collected from non-smoking patients with generalized severe periodontitis (n = 89) and healthy controls (n = 56). Serum and salivary levels of NO metabolites, serum levels of high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides, cholesterol and CRP were measured. Data were analysed in whole population and in different gender groups.
  
  
  RESULTS
  Periodontitis patients exhibited significantly lower serum and saliva levels of NO metabolites and significantly higher LDL, cholesterol and CRP levels than control group. Similar findings were observed within male but not within female population. Serum NO metabolites levels exhibited significant negative correlation with CRP in whole population and in male population. Significant positive correlation of serum NO metabolite levels with HDL levels was observed in whole population.
  
  
  CONCLUSIONS
  NO production is reduced in periodontitis, especially in male population. Gender might be an important factor in assessing risk of cardiovascular disease in periodontitis.
authors: Central Research Unit, Bernhard Gottlieb School of Dentistry, Medical University of Vienna, Vienna, Austria.
authors: Oleh
authors: O
authors: Andrukhov
authors: Hady
authors: H
authors: Haririan
authors: Kristina
authors: K
authors: Bertl
authors: Wolf-Dieter
authors: WD
authors: Rausch
authors: Hans-Peter
authors: HP
authors: Bantleon
authors: Andreas
authors: A
authors: Moritz
authors: Xiaohui
authors: X
authors: Rausch-Fan
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000032:analysis* / Q000097:blood; D008075:Lipoproteins, HDL / Q000032:analysis / Q000097:blood; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000032:analysis* / Q000097:blood; D010518:Periodontitis / Q000097:blood / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry; D012737:Sex Factors; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D009569:Nitric Oxide; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: C-reactive protein; cardiovascular disease; nitric oxide; periodontitis; serum lipids