title: Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth.
abstract: OBJECTIVE
  Children with Down syndrome, the most common genetic cause of intellectual disability, are prone to multiple and varied health-related problems. This study describes patterns of hospitalisations for children and young people with Down syndrome in Western Australia.
  
  
  METHODS
  Birth records were linked to the Western Australian population-based Intellectual Disability database to identify all children born with Down syndrome in Western Australia between 1 January, 1983 and 31 December, 1999. These records were linked to the Hospital Morbidity Data System to provide information on all hospitalisations up to 31 December, 2004. Hospitalisation data, coded using ICD-9CM or ICD-10 (v0.5) were grouped into clinically relevant categories using the primary diagnosis. Rates of hospital admission for all and specific diagnoses were expressed in 1000-person-years at-risk and median age at first admission and length of stay were calculated.
  
  
  RESULTS
  Of the 405 children, 395 had one or more hospital admissions, totalling 3786 admissions for all children and an estimated 39.5 person-years in hospital. On average, children were admitted 9.7 times, with an estimated rate of 757.2 admissions per 1000pyr (95% CI: 680, 843). A quarter of all admissions occurred in the first year of life. The average hospital length of stay was 3.8 days (95% CI: 3.7, 4.1). Upper respiratory tract conditions affected the most children (58.5%) and accounted for 12.1% of all admissions. Other disorders which affected a high percentage of children were ear/hearing conditions (50.6%), disorders of the oral cavity (38.0%) and lower respiratory tract conditions (37.5%). Overall, children with Down syndrome were hospitalised at a rate five times (95% CI = 4.3-6.2) that of the general population.
  
  
  CONCLUSIONS
  Children with Down syndrome are at increased risk of morbidity for varied causes underlining the importance of comprehensive and targeted primary care for this group.
authors: Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, Western Australia, Australia.
authors: Patrick
authors: P
authors: Fitzgerald
authors: Helen
authors: H
authors: Leonard
authors: Terri J
authors: TJ
authors: Pikora
authors: Jenny
authors: J
authors: Bourke
authors: Geoffrey
authors: G
authors: Hammond
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007902:Length of Stay; D008297:Male; D010343:Patient Admission; D062486:Public Health Surveillance; D014904:Western Australia / Q000453:epidemiology; D055815:Young Adult
references: J Pediatr. 2005 Dec;147(6):744-7
references: 16356423
references: Diabetologia. 2006 Jun;49(6):1179-82
references: 16575558
references: Ann Hum Biol. 2005 Mar-Apr;32(2):237-43
references: 16096222
references: Am J Intellect Dev Disabil. 2009 Mar;114(2):100-9
references: 19391670
references: Aust N Z J Public Health. 1999 Oct;23(5):453-9
references: 10575763
references: J Pediatr. 2011 Oct;159(4):541-5
references: 21784457
references: Downs Syndr Res Pract. 2006 Sep;11(2):78-83
references: 17048801
references: Clin Exp Immunol. 2011 Apr;164(1):9-16
references: 21352207
references: Am J Med Genet C Semin Med Genet. 2006 Aug 15;142C(3):131-40
references: 16838306
references: Pediatrics. 2006 Oct;118(4):1633-9
references: 17015556
references: J Paediatr Child Health. 1999 Aug;35(4):383-6
references: 10457298
references: BMC Pediatr. 2009 May 10;9:32
references: 19426556
references: J Intellect Disabil Res. 1995 Jun;39 ( Pt 3):215-32
references: 7640492
references: Arch Intern Med. 2003 Mar 24;163(6):705-11
references: 12639204
references: Pediatrics. 2007 Oct;120(4):e1076-81
references: 17908728
references: Pediatrics. 2009 Feb;123(2):e253-60
references: 19171577
references: J Pediatr. 2011 Feb;158(2):194-200.e1
references: 20934710
references: Child Care Health Dev. 2013 Nov;39(6):789-800
references: 23294187
references: J Intellect Disabil Res. 2002 May;46(Pt 4):310-7
references: 12000582
references: Paediatr Perinat Epidemiol. 2000 Apr;14(2):163-71
references: 10791661
references: Aust N Z J Obstet Gynaecol. 2006 Oct;46(5):427-32
references: 16953858
references: J Intellect Disabil Res. 2007 Mar;51(Pt 3):228-31
references: 17300418
references: Br J Haematol. 2005 Mar;128(6):797-804
references: 15755283
references: Pediatrics. 2009 Oct;124(4):e615-21
references: 19752083
references: Dev Med Child Neurol. 1999 Oct;41(10):683-8
references: 10587045
references: Arch Dis Child. 2009 Jul;94(7):517-23
references: 19060007
references: Arch Dis Child. 2012 Apr;97(4):326-30
references: 21835834
references: Aust N Z J Obstet Gynaecol. 1996 Nov;36(4):385-8
references: 9006817
references: J Intellect Disabil Res. 2007 Dec;51(Pt 12):1030-8
references: 17991010
references: Int J Cancer. 2006 Apr 1;118(7):1769-72
references: 16231334
references: Arch Dis Child. 2005 Dec;90(12):1243-8
references: 16301550
references: J Pediatr Health Care. 2006 Jan-Feb;20(1):47-54
references: 16399479
references: Clin Pediatr (Phila). 2004 Nov-Dec;43(9):783-91
references: 15583773
references: Arch Dis Child. 2004 Nov;89(11):1014-7
references: 15499053
references: J Pediatr. 2012 May;160(5):827-31.e1
references: 22177993
references: Aust Dent J. 2006 Sep;51(3):231-6
references: 17037889
references: Int J Cancer. 2008 Mar 1;122(5):1130-4
references: 17985340
references: Birth Defects Res A Clin Mol Teratol. 2007 Sep;79(9):657-63
references: 17696161
references: Lancet. 2003 Apr 12;361(9365):1281-9
references: 12699967