title: Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer.
abstract: OBJECTIVE
  We investigated the clinical significance of ERp57 in the progression of cervical cancer.
  
  
  METHODS
  mRNA and protein expression of ERp57 in cervical neoplasias were examined.
  
  
  RESULTS
  ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).
  
  
  CONCLUSIONS
  Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
authors: Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA .
authors: Hyunsoo
authors: H
authors: Chung
authors: Hanbyoul
authors: H
authors: Cho
authors: Candice
authors: C
authors: Perry
authors: Jaekyung
authors: J
authors: Song
authors: Kris
authors: K
authors: Ylaya
authors: Heejeong
authors: H
authors: Lee
authors: Jae-Hoon
authors: JH
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D019704:Protein Disulfide-Isomerases / Q000235:genetics* / Q000378:metabolism; D021381:Protein Transport; D046888:Tissue Array Analysis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human