title: Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection.
abstract: Interleukin 27 (IL-27) is an immunomodulatory cytokine with important roles in both the innate and adaptive immune systems. In the last five years, the addition of exogenous IL-27 to primary cell cultures has been demonstrated to decrease HIV-1 replication in a number of cell types including peripheral blood mononuclear cells (PBMCs), CD4+ T cells, macrophages and dendritic cells. These in vitro findings suggest that IL-27 may have therapeutic value in the setting of HIV-1 infection. In this review, we describe the current knowledge of the biology of IL-27, its effects primarily on HIV-1 replication but also in other viral infections and explore its potential role as a therapeutic cytokine for the treatment of patients with HIV-1 infection.
authors: Applied and Developmental Research Directorate, Laboratory of Human Retrovirology, Science Application International Corporation (SAIC)-Frederick, Inc., Frederick National Laboratory for Cancer Research, 1050 Boyles Street, Frederick, MD 21702, USA. Electronic address: sanjay.swaminathan@nih.gov.
authors: Sanjay
authors: S
authors: Swaminathan
authors: Lue
authors: L
authors: Dai
authors: H Clifford
authors: HC
authors: Lane
authors: Tomozumi
authors: T
authors: Imamichi
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D064094:Interleukin-27 / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology; D018123:Receptors, Interleukin / Q000737:chemistry / Q000276:immunology; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: C112441:IL27RA protein, human; D064094:Interleukin-27; D018123:Receptors, Interleukin
keywords: Cytokines; HIV; Interleukin-27; SPTBN1; Therapy
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