title: Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model.
abstract: Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhibitory effects of BM‑06, a double‑stranded (ds)RNA TLR3 agonist, against HCC were studied in vivo. Using a 2‑acetylaminofluorene-induced HCC rat model, histological examination and analysis of corresponding biomarkers following treatment with BM-06, showed a decrease in tumor growth and cell proliferation, and an increase in apoptosis compared with that in a phosphate‑buffered saline control group. In addition, the observed antitumor effect of BM‑06 in the HCC rat model was demonstrated to be superior to the known TLR3 agonist, polyinosinic-polycytidylic acid.
authors: Department of Pathological Anatomy, Nantong University, Nantong, Jiangsu 226001, P.R. China.
authors: Yu-Yin
authors: YY
authors: Xu
authors: Li
authors: L
authors: Chen
authors: Jia-Ming
authors: JM
authors: Zhou
authors: Yuan-Yuan
authors: YY
authors: Wu
authors: Yuan-Yuan
authors: YY
authors: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053181:Caspase 8 / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D004354:Drug Screening Assays, Antitumor; D015870:Gene Expression; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051196:Toll-Like Receptor 3 / Q000819:agonists; D047368:Tumor Burden / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C574691:BM-06; D016328:NF-kappa B; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; C530472:TLR3 protein, rat; D051196:Toll-Like Receptor 3; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D007371:Interferon-gamma; C505528:Casp8 protein, rat; D053181:Caspase 8