title: Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling root systems architecture.
abstract: Phenotypic plasticity is presumed to be involved in adaptive change toward species diversification. We thus examined how candidate genes underlying natural variation across populations might also mediate plasticity within an individual. Our implementation of an integrative "plasticity space" approach revealed that the root plasticity of a single Arabidopsis accession exposed to distinct environments broadly recapitulates the natural variation "space." Genome-wide association mapping identified the known gene PHOSPHATE 1 (PHO1) and other genes such as Root System Architecture 1 (RSA1) associated with differences in root allometry, a highly plastic trait capturing the distribution of lateral roots along the primary axis. The response of mutants in the Columbia-0 background suggests their involvement in signaling key modulators of root development including auxin, abscisic acid, and nitrate. Moreover, genotype-by-environment interactions for the PHO1 and RSA1 genes in Columbia-0 phenocopy the root allometry of other natural variants. This finding supports a role for plasticity responses in phenotypic evolution in natural environments.
authors: Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
authors: Ulises
authors: U
authors: Rosas
authors: Angelica
authors: A
authors: Cibrian-Jaramillo
authors: Daniela
authors: D
authors: Ristova
authors: Joshua A
authors: JA
authors: Banta
authors: Miriam L
authors: ML
authors: Gifford
authors: Angela Huihui
authors: AH
authors: Fan
authors: Royce W
authors: RW
authors: Zhou
authors: Grace Jaeyoon
authors: GJ
authors: Kim
authors: Gabriel
authors: G
authors: Krouk
authors: Kenneth D
authors: KD
authors: Birnbaum
authors: Michael D
authors: MD
authors: Purugganan
authors: Gloria M
authors: GM
authors: Coruzzi
mesh_terms: D000222:Adaptation, Physiological; D017360:Arabidopsis / Q000033:anatomy & histology* / Q000235:genetics* / Q000502:physiology; D029681:Arabidopsis Proteins / Q000235:genetics*; D005075:Biological Evolution; D017343:Genes, Plant; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D009154:Mutation; D010641:Phenotype; D018517:Plant Roots / Q000033:anatomy & histology / Q000502:physiology; D020641:Polymorphism, Single Nucleotide
chemical_list: D029681:Arabidopsis Proteins; C460111:PHO1 protein, Arabidopsis
keywords: GWAS; GxE interaction; QTL; RootScape; morphometrics
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