title: Microbial activation of gut dendritic cells and the control of mucosal immunity.
abstract: Current data support a role for gut colonization in maintaining balanced mucosal and systemic immune responses and have suggested aberrant innate immune recognition of enteric bacteria as an initiator of the adaptive immune damage associated with inflammatory bowel disease (Crohn's disease and ulcerative colitis). In fact, data from human studies and experimental mouse models have implicated transformation of the gut microbiota from a beneficial symbiotic state to one of imbalance or "dysbiosis" in the pathogenesis of several autoinflammatory diseases, including allergic skin and respiratory disorders, rheumatoid arthritis, type I diabetes, and colorectal cancer. The host has evolved to co-exist and maintain a mutualistic relationship with the commensal microbes of the gut, and it is the function of the host innate immune system to initiate and maintain this homeostasis, while retaining the ability to respond appropriately to pathogenic organisms. In this review, we discuss the molecular and cellular interactions of the mucosal immune system that decide this delicate balance of mutualism. Furthermore, we will highlight the role of dendritic cells in preserving this precarious balance and how gene products of commensal microbes may play an integral role in re-establishing this balance once it has gone awry.
authors: 1 Department of Infectious Diseases and Pathology, University of Florida , Gainesville, Florida.
authors: Jennifer L
authors: JL
authors: Owen
authors: Mansour
authors: M
authors: Mohamadzadeh
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*
references: Environ Microbiol. 2010 Dec;12(12):3213-27
references: 20626454
references: Immunol Rev. 2012 Jan;245(1):113-31
references: 22168416
references: Immunity. 2011 Feb 25;34(2):237-46
references: 21333554
references: PLoS One. 2012;7(12):e52119
references: 23284891
references: Science. 2010 Aug 13;329(5993):849-53
references: 20705860
references: Immunity. 2008 Apr;28(4):546-58
references: 18387831
references: J Exp Med. 2012 Sep 24;209(10):1713-22, S1-19
references: 22966003
references: Sci Transl Med. 2012 Dec 12;4(164):164ra159
references: 23241743
references: Nat Immunol. 2008 Jul;9(7):769-76
references: 18516037
references: Mucosal Immunol. 2008 Nov;1(6):432-41
references: 19079210
references: J Immunol. 2011 Jun 1;186(11):6287-95
references: 21525388
references: Gastroenterology. 2004 May;126(5):1358-73
references: 15131797
references: Int J Med Microbiol. 2010 Jan;300(1):25-33
references: 19800289
references: Curr Opin Gastroenterol. 2011 Oct;27(6):496-501
references: 21897224
references: Science. 1965 Feb 12;147(3659):747-8
references: 14242024
references: Blood. 2006 Oct 1;108(7):2307-15
references: 16778140
references: Gastroenterology. 2004 Jul;127(1):365-6
references: 15236225
references: J Clin Gastroenterol. 2011 Nov;45 Suppl:S139-44
references: 21992953
references: Annu Rev Immunol. 2013;31:743-91
references: 23330953
references: Nat Immunol. 2011 Jul 31;12(9):870-8
references: 21804557
references: Nature. 2011 Sep 21;478(7368):250-4
references: 21937990
references: Immunity. 2009 May;30(5):626-35
references: 19464985
references: Int J Food Microbiol. 2012 Jan 16;152(3):189-205
references: 21742394
references: J Immunol. 2010 Feb 15;184(4):2026-37
references: 20089703
references: PLoS Pathog. 2012;8(5):e1002714
references: 22693446
references: PLoS Pathog. 2012;8(7):e1002785
references: 22910541
references: J Immunol. 2012 Oct 15;189(8):3878-93
references: 22972928
references: Trends Microbiol. 2012 Jan;20(1):5-10
references: 22030243
references: Curr Gastroenterol Rep. 2012 Oct;14(5):446-52
references: 22941733
references: Cell Mol Life Sci. 2012 Nov;69(21):3635-50
references: 22527722
references: Semin Immunol. 2011 Feb;23(1):58-64
references: 21292502
references: Nutrients. 2011 Jun;3(6):637-82
references: 22254115
references: Immunity. 2009 Sep 18;31(3):502-12
references: 19733097
references: Curr Gastroenterol Rep. 2012 Aug;14(4):324-33
references: 22581276
references: Inflamm Bowel Dis. 2010 Sep;16(9):1583-97
references: 20803699
references: Nature. 2012 Jul 5;487(7405):104-8
references: 22722865
references: Curr Allergy Asthma Rep. 2013 Feb;13(1):19-26
references: 23054627
references: PLoS One. 2011 Jan 27;6(1):e16393
references: 21297998
references: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19474-9
references: 19047644
references: J Immunol. 2010 Apr 1;184(7):3505-13
references: 20190136
references: J Crohns Colitis. 2013 Sep;7(8):622-30
references: 23014361
references: Nat Rev Immunol. 2010 Jun;10(6):415-26
references: 20498668
references: Front Immunol. 2011 Jul 01;2:25
references: 22566815
references: Inflamm Bowel Dis. 2008 Nov;14(11):1585-96
references: 18623173
references: J Clin Gastroenterol. 2011 Nov;45 Suppl:S115-9
references: 21992949
references: Gut. 2011 Aug;60(8):1050-9
references: 21471573
references: Gastroenterology. 2011 May;140(6):1720-28
references: 21530738
references: Cell Signal. 2012 Dec;24(12):2369-77
references: 22906493
references: FEMS Immunol Med Microbiol. 2007 Aug;50(3):281-3
references: 17651124
references: Annu Rev Immunol. 2012;30:759-95
references: 22224764
references: J Immunol. 2011 Feb 15;186(4):1934-42
references: 21220692
references: Immunity. 2010 Mar 26;32(3):305-15
references: 20346772
references: Appl Microbiol Biotechnol. 2012 Nov;96(4):853-62
references: 23001058
references: Nutr Rev. 2012 Aug;70 Suppl 1:S18-30
references: 22861803
references: Microbes Infect. 2012 Feb;14(2):140-7
references: 21930231
references: Cytokine Growth Factor Rev. 2013 Apr;24(2):91-104
references: 23102645
references: Science. 2011 Oct 7;334(6052):105-8
references: 21885731
references: Nature. 2013 Feb 7;494(7435):116-20
references: 23334413
references: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2159-64
references: 20080669
references: Semin Immunol. 2012 Feb;24(1):43-9
references: 22137188
references: J Immunol. 2009 Mar 15;182(6):3461-8
references: 19265124
references: Nature. 2009 Jan 22;457(7228):480-4
references: 19043404
references: Immunol Cell Biol. 2013 Mar;91(3):240-9
references: 23295361
references: J Immunol. 2009 Feb 15;182(4):2405-15
references: 19201895
references: Lancet. 1998 Oct 10;352(9135):1187-9
references: 9777836
references: Immunity. 2011 May 27;34(5):637-50
references: 21616434
references: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4623-30
references: 21282652
references: J Leukoc Biol. 2008 Jul;84(1):280-91
references: 18458151
references: Intern Med J. 2012 Dec;42(12):1287-91
references: 23252997
references: Gastroenterology. 2011 Mar;140(3):957-65
references: 21147109
references: Front Immunol. 2012 Jun 29;3:178
references: 22754556
references: Immunotherapy. 2012 Feb;4(2):151-61
references: 22339459
references: J Leukoc Biol. 2012 Dec;92(6):1177-86
references: 22966131
references: Curr Opin Rheumatol. 2013 Mar;25(2):248-53
references: 23249830
references: Cytokine. 2011 Nov;56(2):520-30
references: 21889358
references: Dig Dis Sci. 2006 Apr;51(4):677-86
references: 16614988
references: World J Gastroenterol. 2009 Jun 21;15(23):2887-92
references: 19533811
references: FEMS Microbiol Lett. 2011 Jun;319(2):97-105
references: 21388439
references: Front Immunol. 2012 Jul 03;3:183
references: 22783257
references: Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7
references: 22689992
references: Immunotherapy. 2011 Mar;3(3):337-47
references: 21395377
references: Semin Immunol. 2012 Feb;24(1):58-66
references: 22178452
references: J Immunol. 2003 Apr 15;170(8):3939-43
references: 12682220
references: Allergy. 2011 Apr;66(4):499-508
references: 21058959
references: PLoS Genet. 2011 Nov;7(11):e1002355
references: 22072984
references: Mol Immunol. 2011 Sep;48(15-16):2170-7
references: 21835472
references: J Leukoc Biol. 2011 Oct;90(4):669-72
references: 21771898
references: PLoS One. 2011 Apr 18;6(4):e18735
references: 21533162
references: Endocr Pract. 2013 May-Jun;19(3):497-510
references: 23823585
references: Shock. 2010 May;33(5):485-92
references: 19823118
references: Pediatrics. 2010 May;125(5):921-30
references: 20403939
references: Curr Opin Gastroenterol. 2005 Jul;21(4):414-8
references: 15930980
references: Gastroenterology. 2004 Feb;126(2):520-8
references: 14762789
references: Nat Rev Microbiol. 2011 Nov 21;10(1):66-78
references: 22101918
references: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4562-9
references: 20823239
references: Int J Food Microbiol. 1998 Feb 17;39(3):237-8
references: 9553803
references: Mucosal Immunol. 2010 Jan;3(1):17-28
references: 19890268
references: Cell. 2006 Feb 24;124(4):837-48
references: 16497592
references: Nature. 2011 May 12;473(7346):174-80
references: 21508958
references: Gastroenterology. 2011 May;140(6):1729-37
references: 21530739
references: Nat Rev Immunol. 2010 Feb;10(2):131-44
references: 20098461
references: PLoS One. 2010 Jun 10;5(6):e11065
references: 20548777
references: Nat Cell Biol. 2006 Dec;8(12):1327-36
references: 17128265
references: Am J Gastroenterol. 2005 Jul;100(7):1539-46
references: 15984978
references: J Clin Invest. 2005 Mar;115(3):695-702
references: 15765149
references: J Exp Med. 2007 Aug 6;204(8):1757-64
references: 17620361
references: Nat Rev Microbiol. 2012 Sep;10(9):591-2
references: 23066529
references: J Immunol. 2002 Jan 1;168(1):171-8
references: 11751960
references: Physiol Rev. 2010 Jul;90(3):859-904
references: 20664075
references: PLoS One. 2012;7(10):e47244
references: 23056616
references: FEMS Immunol Med Microbiol. 2011 Oct;63(1):93-107
references: 21707779
references: Immunity. 2013 Jan 24;38(1):153-65
references: 23246312
references: Inflamm Bowel Dis. 2011 Jul;17(7):1620-5
references: 21674719
references: J Exp Med. 1999 Oct 4;190(7):995-1004
references: 10510089
references: Science. 2012 Oct 5;338(6103):120-3
references: 22903521
references: Cell Microbiol. 2010 Jul;12(7):881-90
references: 20482555
references: Semin Immunopathol. 2012 Sep;34(5):671-88
references: 22941410
references: Am J Transl Res. 2012;4(2):187-97
references: 22611471
references: Mol Cell Biochem. 2013 Feb;374(1-2):1-11
references: 23271629
references: J Immunol. 2006 Jan 15;176(2):803-10
references: 16393963
references: Eur J Immunol. 2010 Aug;40(8):2107-11
references: 20853495
references: Semin Immunol. 2007 Apr;19(2):116-26
references: 17320411
references: Science. 2006 Jun 2;312(5778):1355-9
references: 16741115
references: Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6578-83
references: 9618454
references: Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2880-5
references: 15710900
references: Nat Rev Immunol. 2012 Jan 25;12(2):101-13
references: 22273772
references: J Allergy Clin Immunol. 2005 Jun;115(6):1260-7
references: 15940144
references: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10321-6
references: 15985548