title: Exercise training in patients with chronic respiratory failure due to kyphoscoliosis: a randomized controlled trial.
abstract: BACKGROUND
  Research has provided evidence for the safety, feasibility, and efficacy of exercise training in patients with COPD. However, little is known about the impact of exercise training in patients with chronic respiratory failure due to kyphoscoliosis. We evaluated the effect of an exercise training program on exercise capacity, muscle strength, dyspnea, and quality-of-life indices in subjects with chronic respiratory failure due to kyphoscoliosis.
  
  
  METHODS
  The 34 subjects were clinically stable, had been receiving nighttime home mechanical ventilation for ≥ 6 months, and were randomly assigned to the exercise group (n = 17) or the control group (n = 17). The exercise group conducted cycle and strength training on 3 non-consecutive days per week for 12 weeks. We measured pulmonary function, exercise capacity, peripheral muscle strength, dyspnea scores, and quality of life.
  
  
  RESULTS
  Statistical analysis was carried out on the data from 16 subjects in the exercise group and in 11 subjects in the control group. Three of the lung-function parameters in the exercise group significantly changed: PaCO2 (P = .04), inspiratory pressure (P = .03), and expiratory pressure (P = .04); and endurance time (P = .002) and shuttle walk distance (P = .001) increased significantly. The exercise group had significantly greater improvements in peripheral muscle strength, dyspnea, and quality of life.
  
  
  CONCLUSIONS
  In patients with chronic respiratory failure due to kyphoscoliosis, exercise training improved exercise capacity, peripheral muscle strength, dyspnea, and quality of life. (Deutschen Register Klinischer Studien DRKS00000443).
authors: Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
authors: Pilar
authors: P
authors: Cejudo
authors: Isabel
authors: I
authors: López-Márquez
authors: José Luis
authors: JL
authors: López-Campos
authors: Eduardo
authors: E
authors: Márquez
authors: Francisco
authors: F
authors: de la Vega
authors: Emilia
authors: E
authors: Barrot
authors: Francisco
authors: F
authors: Ortega
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004417:Dyspnea / Q000209:etiology; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D007738:Kyphosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D011788:Quality of Life; D012131:Respiratory Insufficiency / Q000209:etiology / Q000534:rehabilitation*
keywords: chronic respiratory failure; dyspnea; endurance capacity; exercise training; kyphoscoliosis; peripheral muscle strength; pulmonary rehabilitation; quality of life