title: Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity.
abstract: Tretinoin (TRE) is a widely used retinoid for the topical treatment of acne, psoriasis, skin cancer and photoaging. Despite unmatchable efficacy, it is associated with several vexatious side effects like marked skin erythema, peeling and irritation, eventually leading to poor patient compliance. Its photo-instability and high lipophilicity also pose challenges in the development of a suitable topical product. The present study, therefore, aims to develop biocompatible lipid-based nanocarriers of TRE to improve its skin delivery, photostability, biocompatibility and pharmacodynamic efficacy. The TRE-loaded liposomes, ethosomes, solid lipid nanoparticles (SLNs) and nanostructured lipidic carriers (NLCs) were prepared and characterized for micromeritics, surface charge, percent drug efficiency and morphology. Bioadhesive hydrogels of the developed systems were also evaluated for rheological characterization, photostability, ex vivo skin permeation and retention employing porcine skin, and anti-psoriatic activity in mouse tail model. Nanoparticulate carriers (SLNs, NLCs) offered enhanced photostability, skin transport and anti-psoriatic activity vis-à-vis the vesicular carriers (liposomes, ethosomes) and the marketed product. However, all the developed nanocarriers were found to be more biocompatible and effective than the marketed product. These encouraging findings can guide in proper selection of topical carriers among diversity of such available carriers systems.
authors: UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles and Nanocomposites, Panjab University, Chandigarh 160 014, India.
authors: Kaisar
authors: K
authors: Raza
authors: Bhupinder
authors: B
authors: Singh
authors: Shikha
authors: S
authors: Lohan
authors: Gajanand
authors: G
authors: Sharma
authors: Poonam
authors: P
authors: Negi
authors: Yukhti
authors: Y
authors: Yachha
authors: Om Prakash
authors: OP
authors: Katare
mesh_terms: D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D005260:Female; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry; D011565:Psoriasis / Q000188:drug therapy*; D012869:Skin Absorption; D013472:Sunlight; D014212:Tretinoin / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects
chemical_list: D003879:Dermatologic Agents; D004337:Drug Carriers; D008055:Lipids; D000431:Ethanol; D014212:Tretinoin
keywords: Ethosomes; Liposomes; NLCs; Nanomedicine; Nanoparticles; Nanotechnology; SLNs