title: Autoimmunity in 2012.
abstract: The initiation and perpetuation of autoimmunity recognize numerous checkpoints, from the genomic susceptibility to the breakdown of tolerance. This latter phenomenon includes the loss of B cell anergy and T regulatory cell failure, as well as the production of autoantibodies and autoreactive T cells. These mechanisms ultimately lead to tissue injury via different mechanisms that span from the production of proinflammatory cytokines to the chemotaxis of immune cells to the target sites. The pathways to autoimmunity have been widely investigated over the past year and resulted in a number of articles in peer-reviewed journals that has increased by nearly 10 % compared to 2011. We herein follow on the attempt to provide a brief discussion of the majority of articles on autoimmune diseases that were published in the major immunology journals in the previous solar year. The selection is necessarily arbitrary and may thus not be seen as comprehensive but reflects current research trends. Indeed, 2012 articles were mostly dedicated to define new and old mechanisms with potential therapeutic implications in autoimmunity in general, though based on specific clinical conditions or animal models. As paradigmatic examples, the environmental influence on autoimmunity, Th17 changes modulating the autoimmune response, serum autoantibodies and B cell changes as biomarkers and therapeutic targets were major issues addressed by experimental articles in 2012. Further, a growing number of studies investigated the sex bias of autoimmunity and supported different working hypotheses to explain the female predominance, including sex chromosome changes and reproductive life factors. In conclusion, the resulting scenario illustrates that common factors may underlie different autoimmune diseases and this is well represented by the observed alterations in interferon-α and TGFβ or by the shared signaling pathways.
authors: Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy, cfselmi@ucdavis.edu.
authors: Carlo
authors: C
authors: Selmi
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000266:history / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D035843:Biomedical Research / Q000266:history* / Q000639:trends; D004195:Disease Models, Animal; D005260:Female; D059647:Gene-Environment Interaction; D049674:History, 21st Century; D006801:Humans; D016898:Interferon-alpha / Q000378:metabolism; D058990:Molecular Targeted Therapy; D012737:Sex Factors; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D016898:Interferon-alpha; D016212:Transforming Growth Factor beta
references: J Immunol. 2011 Apr 15;186(8):4668-73
references: 21402892
references: Autoimmunity. 2012 Sep;45(6):485-94
references: 22506635
references: Autoimmun Rev. 2012 May;11(6-7):A377-85
references: 22100310
references: J Immunol. 2011 Oct 15;187(8):4161-9
references: 21908737
references: Autoimmun Rev. 2012 Mar;11(5):341-7
references: 22024499
references: Autoimmunity. 2013 Jun;46(4):238-50
references: 23215763
references: J Immunol. 2012 Jan 15;188(2):559-68
references: 22174447
references: J Immunol. 2012 Sep 15;189(6):3198-208
references: 22875800
references: Autoimmunity. 2011 Sep;44(6):453-64
references: 21604973
references: Clin Rev Allergy Immunol. 2012 Apr;42(2):189-98
references: 21287295
references: Autoimmunity. 2012 Dec;45(8):565-7
references: 22978407
references: Autoimmun Rev. 2012 Jul;11(9):670-7
references: 22155204
references: J Autoimmun. 2012 Dec;39(4):323-31
references: 22578563
references: J Immunol. 2012 Jan 1;188(1):248-58
references: 22105994
references: J Autoimmun. 2011 Feb;36(1):47-55
references: 21050716
references: Nat Immunol. 2011 Apr;12(4):327-34
references: 21297642
references: J Autoimmun. 2012 Sep;39(3):240-7
references: 22704961
references: J Autoimmun. 2011 Sep;37(2):113-21
references: 21621978
references: J Immunol. 2012 May 15;188(10):4769-75
references: 22490866
references: J Immunol. 2012 May 1;188(9):4644-53
references: 22461703
references: Autoimmun Rev. 2012 May;11(6-7):A422-9
references: 22172712
references: Clin Rev Allergy Immunol. 2012 Jun;42(3):265-8
references: 22562625
references: J Immunol. 2012 Apr 15;188(8):3628-38
references: 22407922
references: Autoimmunity. 2012 May;45(3):233-44
references: 22235812
references: Nat Immunol. 2012 Jul 01;13(8):770-7
references: 22751139
references: Autoimmun Rev. 2012 Jul;11(9):611-4
references: 22001419
references: J Immunol. 2012 Jun 15;188(12):5944-53
references: 22593620
references: J Immunol. 2012 Feb 1;188(3):1064-74
references: 22227569
references: Autoimmunity. 2011 May;44(3):219-28
references: 20883149
references: J Autoimmun. 2011 Aug;37(1):48-57
references: 21561736
references: Autoimmun Rev. 2012 Sep;11(11):785-6
references: 22349621
references: J Immunol. 2011 Sep 15;187(6):3338-46
references: 21832158
references: Autoimmun Rev. 2012 Oct;11(12):883-9
references: 22449938
references: Clin Rev Allergy Immunol. 2013 Aug;45(1):87-96
references: 23233263
references: Autoimmunity. 2012 Sep;45(6):449-59
references: 22686732
references: J Immunol. 2012 Jan 15;188(2):678-85
references: 22156495
references: Autoimmunity. 2012 Jun;45(4):320-31
references: 22288464
references: J Immunol. 2012 Feb 15;188(4):1742-50
references: 22238462
references: Autoimmun Rev. 2013 May;12(7):726-40
references: 23266520
references: J Immunol. 2011 Feb 15;186(4):2024-32
references: 21248249
references: Nat Immunol. 2011 Mar;12(3):231-8
references: 21240265
references: Autoimmunity. 2012 Aug;45(5):377-87
references: 22432804
references: J Immunol. 2012 Oct 15;189(8):3878-93
references: 22972928
references: J Immunol. 2012 Aug 15;189(4):1639-47
references: 22798682
references: Autoimmunity. 2012 Nov;45(7):533-9
references: 22816799
references: J Immunol. 2011 Jun 1;186(11):6106-18
references: 21518973
references: Autoimmun Rev. 2012 May;11(6-7):A430-6
references: 22120060
references: Autoimmun Rev. 2012 Dec;12(2):127-36
references: 22776787
references: Autoimmunity. 2012 Jun;45(4):298-303
references: 22276904
references: J Autoimmun. 2012 Aug;39(1-2):57-63
references: 22289719
references: J Immunol. 2012 Feb 15;188(4):1656-67
references: 22231702
references: Autoimmun Rev. 2012 Jan;11(3):159-62
references: 21624507
references: Autoimmunity. 2012 Jun;45(4):271-8
references: 22235789
references: Autoimmun Rev. 2012 Oct;11(12):918-24
references: 23010632
references: J Autoimmun. 2011 Nov;37(3):198-208
references: 21700422
references: J Autoimmun. 2012 Aug;39(1-2):77-82
references: 22402340
references: Autoimmunity. 2012 Nov;45(7):540-6
references: 22849293
references: J Immunol. 2012 Mar 1;188(5):2084-92
references: 22279107
references: Autoimmun Rev. 2012 May;11(6-7):A413-21
references: 22155202
references: J Immunol. 2011 Dec 1;187(11):5684-92
references: 22031758
references: J Immunol. 2012 Dec 15;189(12):5786-96
references: 23150717
references: J Autoimmun. 2012 Sep;39(3):222-8
references: 22704962
references: J Immunol. 2011 May 15;186(10):5569-79
references: 21464089
references: Autoimmunity. 2012 Aug;45(5):415-26
references: 22429146
references: J Autoimmun. 2012 Feb;38(1):29-38
references: 22197557
references: J Immunol. 2012 Feb 1;188(3):1036-48
references: 22198952
references: J Immunol. 2012 Apr 1;188(7):3099-106
references: 22387555
references: J Autoimmun. 2012 May;38(2-3):J156-69
references: 22177232
references: J Immunol. 2012 Sep 15;189(6):2931-40
references: 22896639
references: J Immunol. 2012 Jun 1;188(11):5682-93
references: 22523386
references: Clin Rev Allergy Immunol. 2012 Dec;43(3):207-10
references: 22826113
references: Autoimmun Rev. 2012 Jul;11(9):653-8
references: 22122867
references: J Immunol. 2012 Apr 1;188(7):3315-22
references: 22345646
references: Autoimmun Rev. 2012 Mar;11(5):321-5
references: 21619949
references: J Immunol. 2012 Mar 15;188(6):2876-83
references: 22323541
references: J Autoimmun. 2011 May;36(3-4):278-87
references: 21396797
references: Autoimmun Rev. 2012 Jun;11(8):572-6
references: 22037116
references: J Immunol. 2012 Apr 1;188(7):3138-49
references: 22371394
references: J Immunol. 2011 Apr 1;186(7):4490-9
references: 21357532
references: J Immunol. 2012 Aug 15;189(4):1567-76
references: 22772450
references: Autoimmun Rev. 2012 May;11(6-7):A493-501
references: 22172713
references: Autoimmunity. 2012 Aug;45(5):388-99
references: 22443691
references: Clin Rev Allergy Immunol. 2013 Oct;45(2):256-66
references: 23238772
references: J Immunol. 2012 Dec 1;189(11):5165-70
references: 23109728
references: Nat Immunol. 2011 May;12(5):450-9
references: 21460847
references: Clin Rev Allergy Immunol. 2012 Apr;42(2):113-20
references: 22203433
references: J Autoimmun. 2012 Aug;39(1-2):4-8
references: 22326205
references: J Immunol. 2011 Nov 15;187(10):4998-5006
references: 21984703
references: J Autoimmun. 2012 May;38(2-3):J275-81
references: 22218218
references: Nat Med. 2012 Jun 06;18(6):871-82
references: 22674006
references: J Autoimmun. 2012 Aug;39(1-2):34-42
references: 22178199
references: Autoimmunity. 2012 Aug;45(5):364-76
references: 22429183
references: Autoimmunity. 2012 Feb;45(1):44-54
references: 21923616
references: Autoimmunity. 2012 Mar;45(2):169-75
references: 21875380
references: J Immunol. 2012 Feb 1;188(3):1451-9
references: 22205024
references: Autoimmun Rev. 2012 Nov;12(1):22-30
references: 22878274
references: Clin Rev Allergy Immunol. 2012 Apr;42(2):199-212
references: 21337133
references: Clin Rev Allergy Immunol. 2012 Apr;42(2):145-53
references: 21221847
references: J Autoimmun. 2012 Dec;39(4):451-65
references: 23084980
references: J Immunol. 2011 Sep 1;187(5):2386-93
references: 21810607
references: Autoimmun Rev. 2012 May;11(6-7):A531-7
references: 22155196
references: J Autoimmun. 2012 Aug;39(1-2):83-92
references: 22285554
references: J Immunol. 2011 Sep 15;187(6):2953-65
references: 21859955
references: Autoimmunity. 2012 May;45(3):253-63
references: 22053914
references: J Autoimmun. 2012 May;38(2-3):J245-53
references: 22209097
references: J Immunol. 2012 Mar 1;188(5):2070-3
references: 22291185
references: Autoimmunity. 2011 Dec;44(8):607-15
references: 21604971
references: J Autoimmun. 2011 Nov;37(3):160-70
references: 21689905
references: Autoimmunity. 2012 Jun;45(4):290-7
references: 22390780
references: J Autoimmun. 2012 Dec;39(4):466-70
references: 22871259
references: Autoimmun Rev. 2012 Dec;12(2):323-8
references: 22684016
references: Autoimmunity. 2012 Aug;45(5):348-52
references: 22455598
references: J Immunol. 2012 Jul 15;189(2):711-20
references: 22675201
references: J Immunol. 2011 Feb 15;186(4):2602-12
references: 21217016
references: J Immunol. 2012 Apr 15;188(8):3678-85
references: 22407917
references: Autoimmunity. 2011 Feb;44(1):43-50
references: 20670119
references: Autoimmunity. 2012 Dec;45(8):579-83
references: 22928676
references: Clin Rev Allergy Immunol. 2012 Apr;42(2):256-63
references: 21842235
references: J Autoimmun. 2012 May;38(2-3):J266-74
references: 22284905
references: Clin Rev Allergy Immunol. 2012 Feb;42(1):1-4
references: 22187334
references: J Autoimmun. 2012 May;38(2-3):J177-86
references: 22137891
references: Autoimmun Rev. 2012 Sep;11(11):781-4
references: 22353402
references: J Autoimmun. 2011 Feb;36(1):65-75
references: 21075597
references: Clin Rev Allergy Immunol. 2012 Jun;42(3):309-21
references: 21207191
references: Autoimmun Rev. 2012 May;11(6-7):A386-92
references: 22142547
references: J Immunol. 2012 Jul 1;189(1):120-7
references: 22649193
references: J Immunol. 2012 Aug 15;189(4):1585-93
references: 22778392
references: Autoimmun Rev. 2012 May;11(6-7):A465-70
references: 22155203
references: J Immunol. 2012 Oct 1;189(7):3508-20
references: 22942426
references: J Immunol. 2012 Jun 15;188(12):6287-99
references: 22566565
references: J Autoimmun. 2012 Dec;39(4):272-84
references: 22749494
references: J Immunol. 2012 Feb 1;188(3):1136-46
references: 22210912
references: J Immunol. 2012 Aug 1;189(3):1228-36
references: 22732595
references: J Autoimmun. 2012 May;38(2-3):J223-38
references: 22402339
references: J Autoimmun. 2012 Aug;39(1-2):27-33
references: 22318209
references: Autoimmun Rev. 2012 Oct;11(12):903-8
references: 22498790
references: J Autoimmun. 2012 Jun;38(4):315-21
references: 22342295
references: Autoimmunity. 2012 Dec;45(8):584-7
references: 22928592
references: J Immunol. 2012 Nov 1;189(9):4305-12
references: 23024275
references: J Immunol. 2012 Jan 1;188(1):294-301
references: 22140261
references: J Immunol. 2012 Oct 15;189(8):3925-35
references: 22972930
references: J Immunol. 2011 Jul 1;187(1):133-40
references: 21642544
references: J Autoimmun. 2012 May;38(2-3):J187-92
references: 22178198
references: J Immunol. 2012 Jun 1;188(11):5223-6
references: 22544930
references: J Autoimmun. 2012 Feb;38(1):49-58
references: 22264504
references: Autoimmun Rev. 2012 Feb;11(4):276-80
references: 21840425
references: Nat Immunol. 2011 Jun 26;12(8):796-803
references: 21706005
references: J Autoimmun. 2012 Dec;39(4):253-8
references: 22771005
references: J Autoimmun. 2012 Dec;39(4):304-14
references: 22652418
references: Autoimmunity. 2012 Aug;45(5):400-14
references: 22432732
references: Autoimmunity. 2012 Feb;45(1):36-43
references: 21923617
references: J Immunol. 2012 Jan 1;188(1):216-21
references: 22116823
references: J Autoimmun. 2011 Aug;37(1):28-38
references: 21486688
references: Autoimmunity. 2012 Jun;45(4):279-89
references: 22283427
references: J Autoimmun. 2012 Jun;38(4):293-303
references: 22365785
references: J Immunol. 2011 Sep 15;187(6):2859-66
references: 21824864
references: J Immunol. 2012 Oct 1;189(7):3767-76
references: 22942425
references: Autoimmun Rev. 2013 May;12(7):717-25
references: 23261816
references: J Autoimmun. 2012 Sep;39(3):189-98
references: 22749832
references: J Autoimmun. 2012 Feb;38(1):59-69
references: 22257939
references: Autoimmunity. 2012 Sep;45(6):440-8
references: 22559231
references: J Autoimmun. 2012 Dec;39(4):315-22
references: 22698596
references: Autoimmunity. 2012 Feb;45(1):102-10
references: 21923614
references: J Autoimmun. 2012 Sep;39(3):143-53
references: 22727561
references: Nat Immunol. 2012 May;13(5):481-90
references: 22484734
references: J Immunol. 2012 Jul 15;189(2):669-78
references: 22711892
references: Autoimmun Rev. 2012 May;11(6-7):A460-4
references: 22155198
references: J Autoimmun. 2012 May;38(2-3):J197-208
references: 22204899
references: J Autoimmun. 2012 Dec;39(4):285-93
references: 22748431
references: Autoimmunity. 2012 Sep;45(6):460-9
references: 22559266
references: Nat Immunol. 2012 Apr 29;13(6):596-603
references: 22544392
references: J Autoimmun. 2012 May;38(2-3):J193-6
references: 22196921
references: J Autoimmun. 2012 Dec;39(4):249-52
references: 22980030
references: J Autoimmun. 2012 Dec;39(4):388-97
references: 22867713
references: J Immunol. 2012 Feb 1;188(3):1206-12
references: 22184727
references: J Immunol. 2012 Apr 1;188(7):3188-98
references: 22368274
references: Autoimmunity. 2012 May;45(3):210-7
references: 22053866
references: J Autoimmun. 2012 Sep;39(3):173-9
references: 22695187
references: J Autoimmun. 2011 Dec;37(4):319-27
references: 21959269
references: Nat Immunol. 2012 Nov;13(11):1110-7
references: 23042150
references: J Autoimmun. 2012 Dec;39(4):332-46
references: 22647731
references: J Immunol. 2012 May 1;188(9):4171-80
references: 22450809
references: J Autoimmun. 2012 Dec;39(4):259-71
references: 22739348
references: J Immunol. 1995 Aug 1;155(3):1151-64
references: 7636184
references: J Immunol. 2012 Dec 1;189(11):5105-11
references: 23169863
references: J Immunol. 2012 Dec 1;189(11):5097-100
references: 23169861
references: Clin Rev Allergy Immunol. 2012 Feb;42(1):26-34
references: 22189514
references: J Immunol. 2012 Jan 1;188(1):21-8
references: 22187483
references: Autoimmunity. 2011 Feb;44(1):51-7
references: 20670118
references: J Immunol. 2012 Dec 1;189(11):5434-41
references: 23109726
references: J Immunol. 2012 Jun 15;188(12):6027-35
references: 22561151
references: J Immunol. 2012 Feb 15;188(4):1717-25
references: 22246624
references: J Autoimmun. 2012 Aug;39(1-2):112-6
references: 22297145
references: Autoimmunity. 2012 Nov;45(7):547-55
references: 22849322
references: Clin Rev Allergy Immunol. 2012 Feb;42(1):92-101
references: 22161696
references: Autoimmunity. 2012 Feb;45(1):55-70
references: 21923615
references: J Immunol. 2012 Sep 15;189(6):3043-53
references: 22888137
references: Autoimmun Rev. 2012 May;11(6-7):A393-403
references: 22182796
references: J Autoimmun. 2012 May;38(2-3):J71-3
references: 22222237
references: J Immunol. 2012 Feb 15;188(4):1874-83
references: 22262655
references: Autoimmunity. 2012 Jun;45(4):310-9
references: 22390157
references: Autoimmunity. 2012 May;45(3):226-32
references: 22053898
references: Autoimmun Rev. 2011 Oct;10(12):809-10
references: 21376142
references: Autoimmun Rev. 2012 Dec;12(2):281-8
references: 22575366
references: Autoimmunity. 2012 Dec;45(8):597-601
references: 22913420
references: Autoimmunity. 2012 Nov;45(7):556-64
references: 22559288
references: J Immunol. 2011 Sep 1;187(5):2061-6
references: 21856944
references: J Autoimmun. 2012 Aug;39(1-2):1-3
references: 22361268
references: Autoimmunity. 2012 Mar;45(2):161-8
references: 22011088
references: J Immunol. 2012 Apr 1;188(7):3062-70
references: 22379034
references: Autoimmun Rev. 2012 Mar;11(5):301-4
references: 20230920
references: Autoimmun Rev. 2012 Jul;11(9):664-9
references: 22155015
references: J Immunol. 2012 May 15;188(10):4792-800
references: 22516957
references: J Autoimmun. 2012 May;38(2-3):J254-65
references: 22204900
references: J Autoimmun. 2012 Sep;39(3):180-8
references: 22727274
references: Nat Immunol. 2012 Nov;13(11):1022-5
references: 23080193
references: Nat Immunol. 2011 Jun;12(6):467-71
references: 21739668
references: Clin Rev Allergy Immunol. 2012 Aug;43(1-2):194-206
references: 22733376
references: Autoimmun Rev. 2012 May;11(6-7):A538-43
references: 22154619
references: Clin Rev Allergy Immunol. 2012 Dec;43(3):256-64
references: 22648455
references: Autoimmunity. 2012 Aug;45(5):353-63
references: 22432771
references: J Autoimmun. 2012 Dec;39(4):294-303
references: 22560973
references: Autoimmun Rev. 2012 Dec;12(2):150-6
references: 22504460
references: J Autoimmun. 2011 Dec;37(4):300-10
references: 21962567
references: J Immunol. 2012 Jul 15;189(2):1081-93
references: 22723520
references: J Immunol. 2011 May 15;186(10):5738-48
references: 21471445
references: J Autoimmun. 2012 Aug;39(1-2):103-11
references: 22341852