title: An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis).
abstract: We herein report an autopsy case of the Marburg variant of multiple sclerosis (MS). A 29-year-old woman developed acute and progressive neurological symptoms. A diagnosis of MS was suspected based on the patient's clinical background and brain MRI findings and the lack of evidence of malignancy on a brain biopsy. Despite the administration of typical treatment for MS, a fatal outcome occurred three months after disease onset. The autopsy revealed multiple inflammatory demyelinating lesions in the central nervous system. In addition, two noteworthy histopathological features were observed compared with prototypical MS. We evaluate the pathogenic differences between the Marburg type and prototypical MS by discussing the neuropathology and cerebrospinal fluid (CSF) findings of our case.
authors: The First Department of Medicine, Department of Neurology, Hamamatsu University School of Medicine, Japan. ms1015@hama-med.ac.jp
authors: Makiko
authors: M
authors: Suzuki
authors: Hideya
authors: H
authors: Kawasaki
authors: Katsuhisa
authors: K
authors: Masaki
authors: Satoshi O
authors: SO
authors: Suzuki
authors: Tatsuhiro
authors: T
authors: Terada
authors: Takashi
authors: T
authors: Tsuchida
authors: Tsutomu
authors: T
authors: Tokuyama
authors: Satoshi
authors: S
authors: Kono
authors: Takashi
authors: T
authors: Komori
authors: Satoshi
authors: S
authors: Baba
authors: Jun-ichi
authors: J
authors: Kira
authors: Hiroaki
authors: H
authors: Miyajima
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008379:Marburg Virus Disease / Q000150:complications / Q000473:pathology*; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*