title: Clinical Aspects of Huntington's Disease.
abstract: Huntington's disease (HD) is a devastating inherited neurodegenerative condition characterized by progressive motor, cognitive, and psychiatric symptoms. Symptoms progress over 15-20 years, and there are currently no disease-modifying therapies. The causative genetic mutation is an expanded CAG repeat in the HTT gene encoding the Huntingtin protein, and is inherited in an autosomal dominant manner. In this chapter we discuss the genetics, clinical presentation, and management of this condition, as well as new data from large-scale clinical research studies on the natural history of HD.
authors: Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK.
authors: Rhia
authors: R
authors: Ghosh
authors: Sarah J
authors: SJ
authors: Tabrizi
mesh_terms: D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000503:physiopathology / Q000628:therapy