title: The use of bayesian latent class cluster models to classify patterns of cognitive performance in healthy ageing.
abstract: The main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing. Principal component analysis (PCA) was used to detect main cognitive dimensions (based on the neurocognitive test variables) and Bayesian latent class analysis (LCA) models (without constraints) were used to explore patterns of cognitive performance among community-dwelling older individuals. Gender, age and number of school years were explored as variables. Three cognitive dimensions were identified: general cognition (MMSE), memory (MEM) and executive (EXEC) function. Based on these, three latent classes of cognitive performance profiles (LC1 to LC3) were identified among the older adults. These classes corresponded to stronger to weaker performance patterns (LC1>LC2>LC3) across all dimensions; each latent class denoted the same hierarchy in the proportion of males, age and number of school years. Bayesian LCA provided a powerful tool to explore cognitive typologies among healthy cognitive agers.
authors: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal ; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
authors: Patrício Soares
authors: PS
authors: Costa
authors: Nadine Correia
authors: NC
authors: Santos
authors: Pedro
authors: P
authors: Cunha
authors: Joana Almeida
authors: JA
authors: Palha
authors: Nuno
authors: N
authors: Sousa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D001499:Bayes Theorem; D016000:Cluster Analysis; D003071:Cognition; D056344:Executive Function; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008390:Markov Chains; D008568:Memory; D008875:Middle Aged; D008960:Models, Psychological; D009010:Monte Carlo Method; D009483:Neuropsychological Tests
references: Neuropsychology. 2010 Mar;24(2):273-8
references: 20230122
references: Biometrics. 2003 Mar;59(1):189-96; discussion 197-8
references: 12762457
references: Psychosomatics. 2009 May-Jun;50(3):248-54
references: 19567764
references: J Clin Exp Neuropsychol. 2009 May;31(4):412-24
references: 18720183
references: Neurology. 2009 Feb 3;72(5):460-5
references: 19188578
references: Arch Clin Neuropsychol. 2000 Aug;15(6):495-513
references: 14590204
references: Biochim Biophys Acta. 2012 Mar;1822(3):467-73
references: 21982946
references: Int Psychogeriatr. 1997;9 Suppl 1:87-94; discussion 143-50
references: 9447431
references: Med Educ. 2011 Mar;45(3):308-16
references: 21299605
references: BMJ. 2002 Jun 22;324(7352):1502-5
references: 12077041
references: J Psychiatr Res. 1975 Nov;12(3):189-98
references: 1202204
references: PLoS One. 2012;7(7):e40633
references: 22844405
references: Am J Geriatr Psychiatry. 2009 May;17(5):387-96
references: 19390296
references: Age (Dordr). 2013 Oct;35(5):1983-93
references: 23054829
references: Age Ageing. 1990 Mar;19(2):91-6
references: 2337015
references: Psychol Med. 1997 Nov;27(6):1337-44
references: 9403905
references: Obstet Gynecol Clin North Am. 2011 Sep;38(3):519-35
references: 21961718
references: J Int Neuropsychol Soc. 2010 Sep;16(5):754-60
references: 20673381
references: BMC Proc. 2007;1 Suppl 1:S112
references: 18466453
references: Dialogues Clin Neurosci. 2002 Jun;4(2):197-210
references: 22033483
references: PLoS One. 2011;6(9):e24553
references: 21931752
references: J Am Geriatr Soc. 1992 Sep;40(9):922-35
references: 1512391
references: Psychol Aging. 2012 Sep;27(3):707-19
references: 22201331
references: J Neurosci Nurs. 2008 Aug;40(4):241-9
references: 18727340
references: J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):29-32
references: 11413258
references: J Int Neuropsychol Soc. 1995 Sep;1(5):483-93
references: 9375233
references: Neuropsychologia. 2009 Aug;47(10):2015-28
references: 19467352
references: Arch Gen Psychiatry. 2005 Dec;62(12):1343-51
references: 16330722