title: DNA damage and oxidative stress in patients with mild preeclampsia and offspring.
abstract: OBJECTIVE
  Oxidative stress has been shown to play an important role in the pathogenesis of pre-eclampsia, and DNA damage frequently occurs in cells exposed to such stress. The aim of the present study was to investigate DNA damage and oxidative stress in mildly pre-eclamptic women and their offspring.
  
  
  METHODS
  We studied 25 mildly pre-eclamptic mothers, 20 healthy controls, and their infants. Mononuclear leukocyte DNA damage, total antioxidant status (TAS), and total oxidant status (TOS) were determined and the oxidative stress index (OSI) was calculated.
  
  
  RESULTS
  DNA damage, and TOS and OSI levels were significantly increased, and TAS levels significantly decreased, in maternal and cord blood samples of the mildly pre-eclamptic group. A positive correlation between the extent of DNA damage and diastolic blood pressure was evident in pre-eclamptic mothers and there was a negative correlation between the extent of DNA damage and TOS.
  
  
  CONCLUSIONS
  Both oxidative stress and DNA damage are elevated in mildly pre-eclamptic patients and their offspring. Increased oxidative stress may be important in inducing DNA damage in pre-eclamptic patients.
authors: Department of Obstetrics and Gynecology, University of Harran, Medical Faculty, Sanliurfa, Turkey. Electronic address: nesehilali@gmail.com.
authors: Nese
authors: N
authors: Hilali
authors: Abdurrahim
authors: A
authors: Kocyigit
authors: Mehmet
authors: M
authors: Demir
authors: Aysun
authors: A
authors: Camuzcuoglu
authors: Adnan
authors: A
authors: Incebiyik
authors: Hakan
authors: H
authors: Camuzcuoglu
authors: Mehmet
authors: M
authors: Vural
authors: Abdullah
authors: A
authors: Taskin
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004249:DNA Damage; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
keywords: DNA damage; Oxidative stress; Pre-eclampsia; Total antioxidant status