title: Serum ghrelin is associated with verbal learning and adiposity in a sample of healthy, fit older adults.
abstract: The purpose of the present investigation was to determine the relationship between serum ghrelin concentrations, adiposity, and verbal learning in a group of healthy, fit older adults. Participants were 28 healthy older adults (age: 70.8 ± 9.3 yrs, BMI: 27.3 ± 5.7). Participants reported to the laboratory and basic anthropometric data were collected, followed by a blood draw to quantify serum ghrelin. Participants then underwent cognitive testing that included the revised Hopkins Verbal Learning Test (HVLT), as well as the Mini-Mental Status Exam (MMSE). The results of the MMSE test revealed that the volunteers were cognitively intact (MMSE 27.6 ± 1.8). A significant correlation emerged between serum ghrelin concentrations, 2 trials of the HVLT (Trial 1: r = 0.316, P = 0.05; Trial 2: r = 0.395, P = 0.03), and the sum of three-site skinfold analysis (r = 0.417, P = 0.015). Based upon the aforementioned relationships, it appears that fasting levels of serum ghrelin are related to both verbal learning and adiposity in healthy, fit older adults.
authors: Department of Kinesiology, University of Louisiana Lafayette, Lafayette, LA 70504, USA. dmb1527@louisiana.edu
authors: David
authors: D
authors: Bellar
authors: Ellen L
authors: EL
authors: Glickman
authors: Lawrence W
authors: LW
authors: Judge
authors: John
authors: J
authors: Gunstad
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014706:Verbal Learning / Q000502:physiology*
chemical_list: D015415:Biomarkers; D054439:Ghrelin
references: Behav Brain Res. 2009 Jul 19;201(1):166-72
references: 19428630
references: J Neurosci. 2009 Nov 11;29(45):14057-65
references: 19906954
references: Br J Nutr. 1978 Nov;40(3):497-504
references: 718832
references: J Nutr Health Aging. 2009 May;13(5):414-20
references: 19390747
references: J Clin Endocrinol Metab. 2004 Feb;89(2):936-9
references: 14764817
references: Regul Pept. 2012 Jan 10;173(1-3):21-6
references: 21906630
references: Am J Clin Nutr. 1997 Oct;66(4):803-9
references: 9322553
references: Psychopharmacology (Berl). 2009 Oct;206(3):415-27
references: 19652956
references: Am J Hum Biol. 2009 May-Jun;21(3):404-6
references: 19213003
references: J Pharmacol Exp Ther. 2002 Aug;302(2):822-7
references: 12130749
references: J Neurosci Res. 1999 Jun 15;56(6):565-70
references: 10374811
references: Eur J Endocrinol. 2002 Jun;146(6):839-45
references: 12039705
references: Front Neuroendocrinol. 2010 Jan;31(1):44-60
references: 19896496
references: Nature. 1999 Dec 9;402(6762):656-60
references: 10604470
references: Med Sci Sports Exerc. 1980;12(3):175-81
references: 7402053
references: Physiol Behav. 2010 Aug 4;101(1):117-23
references: 20451534
references: Am J Clin Nutr. 2009 May;89(5):1410-7
references: 19339394
references: Am J Epidemiol. 1989 Sep;130(3):578-87
references: 2764002
references: J Int Neuropsychol Soc. 2000 Jul;6(5):529-38
references: 10932472
references: Nat Rev Endocrinol. 2013 Jun;9(6):357-65
references: 23629538
references: Eur J Clin Nutr. 2003 Sep;57 Suppl 1:S54-7
references: 12947454
references: Nat Neurosci. 2006 Mar;9(3):381-8
references: 16491079
references: J Nutr Health Aging. 2011 Dec;15(10):863-7
references: 22159774