title: Biodegradable polyesters containing ibuprofen and naproxen as pendant groups.
abstract: Controlled release of nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen could be beneficial for the treatment of inflammatory diseases while reducing the side effects resulting from their continuous use. Novel biodegradable polyesters solely comprised of biocompatible components (e.g., tartaric acid, 1,8-octanediol, and ibuprofen or naproxen as pendant groups) have been synthesized using tin(II) 2-ethylhexanoate as catalyst at 130 °C and subsequently characterized to determine their structures and physicochemical properties. The polymers release the free drug (ibuprofen or naproxen) in vitro in a controlled manner without burst release, unlike the release rates achieved when the drugs are encapsulated in other polymers. These new biomaterials are not cytotoxic toward mouse fibroblasts up to 0.10 mg/mL. The drugs retain their chemical structure following hydrolytic degradation of the polymer, suggesting that bioactivity is preserved.
authors: Department of Chemistry and Chemical Biologyand ‡Department of Biomedical Engineering, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors: Roselin
authors: R
authors: Rosario-Meléndez
authors: Weiling
authors: W
authors: Yu
authors: Kathryn E
authors: KE
authors: Uhrich
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D007052:Ibuprofen / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D011091:Polyesters; D009288:Naproxen; D007052:Ibuprofen
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