title: Breast metastases from oligodendroglioma: an unusual extraneural spread in two young women and a review of the literature.
abstract: BACKGROUND
  Extraneural dissemination of oligodendroglioma is rare. Cases of breast metastases have never been described in the literature.
  
  
  METHODS
  We report the first two cases of young women with initial diagnosis of anaplastic oligodendroglioma who experienced mammary gland metastases and a review of the literature.
  
  
  RESULTS
  Immunohistochemical analysis performed on material from both primary and metastatic sites did not allow to draw any conclusion on possible etiopathogenetic hypothesis. A review of literature yielded 35 cases of extracranial metastatic oligodendroglioma from 1989 to 2012.
  
  
  CONCLUSIONS
  Though rare, extracranial dissemination from oligodendroglioma may occur not only in long surviving heavily pre-treated patients. The review of literature and these two cases suggest that spread is primarily to bone and then from bone to other organs through hematogenous route mostly due to leptomeningeal or dura mater invasion. Chemotherapy regimens similar to those commonly used for non metastatic oligodendroglioma are recommended for patients with good performance status.
authors: Department of Medical Oncology, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy.
authors: E
authors: E
authors: Mazza
authors: C
authors: C
authors: Belli
authors: M
authors: M
authors: Terreni
authors: C
authors: C
authors: Doglioni
authors: C
authors: C
authors: Losio
authors: M
authors: M
authors: Cantore
authors: A
authors: A
authors: Mambrini
authors: M
authors: M
authors: Reni
mesh_terms: D000328:Adult; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D060787:Neoplasm Grading; D009389:Neovascularization, Pathologic / Q000175:diagnosis; D009837:Oligodendroglioma / Q000175:diagnosis / Q000473:pathology*
keywords: Brain tumors; Breast; Metastasis; Oligodendroglioma