title: Pyranocoumarins from Zosima absinthifolia (Vent) Link roots.
abstract: Zosima absinthifolia (Vent) Link (Apiaceae) is a perennial herb indigenous to Iran. It has been used as a medicinal plant from ancient time in Iran, Turkey and Pakistan. In the present work, air-dried and powdered plant roots were extracted with n-hexane, dichloromethane and methanol, respectively, using Soxhlet apparatus. The dichloromethane extract was subjected to vacuum liquid chromatography (VLC) and preparative thin layer chromatography (P-TLC) to yield two pyranocoumarins, aegelinol and agasyllin. The antimicrobial assay was performed using agar dilution method. The results showed that purified compounds have modest to weak antibacterial and antifungal activity.
authors: Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. razavi694@gmail.com
authors: Seyed Mehdi
authors: SM
authors: Razavi
authors: Gholamhasan
authors: G
authors: Imanzadeh
authors: Fatemeh Soghra
authors: FS
authors: Jahed
authors: Gholamreza
authors: G
authors: Zarrini
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects*; D002855:Chromatography, Thin Layer; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D006586:Hexanes / Q000737:chemistry; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D039681:Pyranocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D006586:Hexanes; D010936:Plant Extracts; D039681:Pyranocoumarins; C026385:n-hexane; C547463:aegelinol