title: Associations between vascular endothelial growth factor gene polymorphisms and pre-eclampsia susceptibility: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to assess whether vascular endothelial growth factor (VEGF) polymorphisms are associated with susceptibility to pre-eclampsia.
  
  
  METHODS
  A meta-analysis was conducted on the associations between the -634 C/G, +936 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and pre-eclampsia.
  
  
  RESULTS
  Ten studies involving 2068 subjects (pre-eclampsia, 950; controls, 1118) were included in the meta-analysis. The meta-analysis revealed an association between pre-eclampsia and the VEGF -634 C allele in overall group (OR = 1.351, 95% CI = 1.105-1.651, p = 0.003) and in European group (OR = 1.427, 95% CI = 1.139-1.787, p = 0.002). The meta-analysis revealed an association between pre-eclampsia and the VEGF -936 T allele in Asians, but not in Europeans (OR = 1.555, 95% CI = 1.232-1.961, p = 1.9 × 10(-5); OR = 1.587, 95% CI = 0.933-2.699, p = 0.088). However, the meta-analysis revealed no association between pre-eclampsia and the VEGF -1154 A/G and 2578 A/C polymorphisms
  
  
  CONCLUSIONS
  This meta-analysis suggested that the VEGF -634 C/G polymorphism is associated with susceptibility to pre-eclampsia in Europeans and that the VEGF -634 C/G polymorphism is associated with pre-eclampsia in Asians.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
authors: Gwan Gyu
authors: GG
authors: Song
authors: Jae-Hoon
authors: JH
authors: Kim
authors: Young Ho
authors: YH
authors: Lee
mesh_terms: D000818:Animals; D044466:Asian People; D004252:DNA Mutational Analysis; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D044465:White People
chemical_list: D042461:Vascular Endothelial Growth Factor A