title: Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders.
abstract: Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization.
authors: Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano (Sa), Italy. mcmonti@unisa.it.
authors: Chiara
authors: C
authors: Cassiano
authors: Roberta
authors: R
authors: Esposito
authors: Alessandra
authors: A
authors: Tosco
authors: Angela
authors: A
authors: Zampella
authors: Maria Valeria
authors: MV
authors: D'Auria
authors: Raffaele
authors: R
authors: Riccio
authors: Agostino
authors: A
authors: Casapullo
authors: Maria Chiara
authors: MC
authors: Monti
mesh_terms: D000818:Animals; D004277:DNA, Single-Stranded / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D016328:NF-kappa B / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D016328:NF-kappa B; D013729:Terpenes; C493748:heteronemin