title: The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children.
abstract: Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1-4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I-related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes.
authors: Onco-Hematology Unit, Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland ; CANSEARCH Research Center, Geneva Medical University, Geneva, Switzerland ; Charles-Bruneau Cancer Center, CHU Sainte-Justine Research Center, Montreal, QC, Canada.
authors: Marc
authors: M
authors: Ansari
authors: Chakradhara Rao S
authors: CR
authors: Uppugunduri
authors: Sylvie
authors: S
authors: Ferrari-Lacraz
authors: Henrique
authors: H
authors: Bittencourt
authors: Fabienne
authors: F
authors: Gumy-Pause
authors: Yves
authors: Y
authors: Chalandon
authors: Jean-Marie
authors: JM
authors: Tiercy
authors: Tal
authors: T
authors: Schechter
authors: Adam
authors: A
authors: Gassas
authors: John D
authors: JD
authors: Doyle
authors: Lee
authors: L
authors: Dupuis
authors: Michel
authors: M
authors: Duval
authors: Maja
authors: M
authors: Krajinovic
authors: Jean
authors: J
authors: Villard
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015234:HLA-A Antigens
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