title: Nek8 couples renal ciliopathies to DNA damage and checkpoint control.
abstract: In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.
authors: Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. pjackson@stanford.edu
authors: Peter K
authors: PK
authors: Jackson
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002923:Cilia / Q000473:pathology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D004261:DNA Replication / Q000235:genetics*; D006801:Humans; D000072379:NIMA-Related Kinases; D007690:Polycystic Kidney Diseases / Q000473:pathology*; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016196:S Phase / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D011494:Protein Kinases; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C458529:NEK8 protein, human; D000072379:NIMA-Related Kinases; D017346:Protein Serine-Threonine Kinases; D018844:Cyclin-Dependent Kinases