title: Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones.
abstract: The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.
authors: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors: Wenbin
authors: W
authors: Wu
authors: Xiaoqian
authors: X
authors: Yuan
authors: Juan
authors: J
authors: Hu
authors: Xinxin
authors: X
authors: Wu
authors: Yuan
authors: Y
authors: Wei
authors: Zunwu
authors: Z
authors: Liu
authors: Junzhu
authors: J
authors: Lu
authors: Jinxing
authors: J
authors: Ye
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D006835:Hydrazones; D007659:Ketones; D011724:Pyridazines