title: A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank.
abstract: Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Jon B
authors: JB
authors: Toledo
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Vivianna M
authors: VM
authors: Van Deerlin
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Edward B
authors: EB
authors: Lee
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: EunRan
authors: E
authors: Suh
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Young
authors: Y
authors: Baek
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: John L
authors: JL
authors: Robinson
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Sharon X
authors: SX
authors: Xie
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Jennifer
authors: J
authors: McBride
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Elisabeth M
authors: EM
authors: Wood
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Theresa
authors: T
authors: Schuck
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: David J
authors: DJ
authors: Irwin
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Rachel G
authors: RG
authors: Gross
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Howard
authors: H
authors: Hurtig
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Leo
authors: L
authors: McCluskey
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Lauren
authors: L
authors: Elman
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Jason
authors: J
authors: Karlawish
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Gerard
authors: G
authors: Schellenberg
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Alice
authors: A
authors: Chen-Plotkin
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: David
authors: D
authors: Wolk
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Murray
authors: M
authors: Grossman
authors: Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors: Steven E
authors: SE
authors: Arnold
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Leslie M
authors: LM
authors: Shaw
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA.
authors: Virginia M-Y
authors: VM
authors: Lee
authors: Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania, USA. Electronic address: trojanow@mail.med.upenn.edu.
authors: John Q
authors: JQ
authors: Trojanowski
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D018070:Biological Specimen Banks / Q000706:statistics & numerical data*; D002490:Central Nervous System / Q000378:metabolism*; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D005838:Genotype; D006785:Hospitals, University; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology*; D010414:Pennsylvania; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins
keywords: Alzheimer's Disease; Autopsy; Cerebrospinal fluid; Dementia; Frontotemporal lobar degeneration; Genetics; Neurodegeneration; Parkinson's Disease; Plasma; Serum
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