title: Mimicking bone nanostructure by combining block copolymer self-assembly and 1D crystal nucleation.
abstract: The orientation and spatial distribution of nanocrystals in the organic matrix are two distinctive structural characteristics associated with natural bone. Synthetic soft materials have been used to successfully control the orientation of mineral crystals. The spatial distribution of minerals in a synthetic scaffold, however, has yet to be reproduced in a biomimetic manner. Herein, we report using block copolymer-decorated polymer nanofibers to achieve biomineralized fibrils with precise control of both mineral crystal orientation and spatial distribution. Exquisite nanoscale structural control in biomimetic hybrid materials has been demonstrated.
authors: Department of Materials Science and Engineering, Drexel University , 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States.
authors: Xi
authors: X
authors: Chen
authors: Wenda
authors: W
authors: Wang
authors: Shan
authors: S
authors: Cheng
authors: Bin
authors: B
authors: Dong
authors: Christopher Y
authors: CY
authors: Li
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D018786:Bone Substitutes / Q000138:chemical synthesis*; D003460:Crystallization / Q000379:methods*; D008422:Materials Testing; D008968:Molecular Conformation; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis*; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D018786:Bone Substitutes; D011091:Polyesters; C016240:polycaprolactone; C006903:carbopol 940