title: Correlation between classical rheometry and supersonic shear wave imaging in blood clots.
abstract: The assessment of coagulating blood elasticity has gained importance as a result of several studies that have correlated it to cardiovascular pathologic conditions. In this study we use supersonic shear wave imaging (SSI) to measure viscoelastic properties of blood clots. At the same time, classical rheometry experiments were carried out on the same blood samples taken within the first few seconds of coagulation. Using SSI, phase velocities of the shear wave indicated increasing dispersion with time. In all cases, the frequency bandwidth of propagating shear waves changed from 20-50 Hz at the first few min of coagulation to around 300 Hz toward the end of experiments. Using the values of G' and G″ from the rheometry studies, the theoretical shear wave velocities were calculated and correlated with SSI measurements. Results of the two techniques were in very good agreement, confirming that SSI provides accurate measurements of viscoelastic properties as corroborated by conventional rheometric measurements.
authors: Institut Langevin - Ondes et Images, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris, France.
authors: Miguel
authors: M
authors: Bernal
authors: Jean-Luc
authors: JL
authors: Gennisson
authors: Patrice
authors: P
authors: Flaud
authors: Mickael
authors: M
authors: Tanter
mesh_terms: D000818:Animals; D001769:Blood / Q000000981:diagnostic imaging*; D001777:Blood Coagulation / Q000528:radiation effects*; D001809:Blood Viscosity / Q000502:physiology*; D001811:Blood Volume Determination / Q000379:methods*; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D018056:Hemorheology; D066298:In Vitro Techniques; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine
keywords: Coagulation; Deep venous thrombosis; Dispersion; Rheometry; Supersonic shear imaging; Viscoelasticity