title: Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.
abstract: The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
authors: Department of Biotechnology, Catholic University of Daegu, Gyungbuk 712-702, Korea.
authors: Byung-Keun
authors: BK
authors: Yang
authors: Seung-Lark
authors: SL
authors: Hwang
authors: Ik-Jin
authors: IJ
authors: Yun
authors: Eun-Ju
authors: EJ
authors: Do
authors: Won-Ha
authors: WH
authors: Lee
authors: Young-Mi
authors: YM
authors: Jung
authors: Sung-Chang
authors: SC
authors: Hong
authors: Dong-Chan
authors: DC
authors: Park
keywords: Anticomplementary; Antitumor; Colon cancer; Keumsa Linteusan; Macrophage lysosomal enzyme; Mouse model; Phellinus linteus
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