title: Phenanthrenes from Juncus effusus.
abstract: A chemical investigation of the EtOAc-soluble fraction from the ethanol extract of the medullae of Juncus effusus led to the isolation of three new 9,10-dihydrophenanthrenes, juncuenins E-G (1-3); two new phenanthrenes, dehydrojuncuenins D-E (4-5); one new feruloylated glycoside (6); and one known 9,10-dihydrophenanthrene (7). The structures of these compounds were determined by analyzing their spectroscopic data. Metabolites 1-4 and 7 were further evaluated for their in vitro cytotoxic activities against seven human cancer lines (A549, MCF-7, BEL-7402, HeLa, COLO205, BGC-823, and SK-OV-3). Among them, compound 1 exhibited weak cytotoxicity against MCF-7 and HeLa cell lines. Compound 7 showed moderate cytotoxicity against MCF-7 and HeLa cell lines, with IC50 values of 9.17 and 19.6 µM, respectively.
authors: Department of Pharmaceutics & Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu, China.
authors: Xue-Hui
authors: XH
authors: Su
authors: Zhi-Peng
authors: ZP
authors: Yuan
authors: Cong-Ying
authors: CY
authors: Li
authors: Yu-Jiao
authors: YJ
authors: Zhong
authors: Hong-Jian
authors: HJ
authors: Du
authors: Ya-Ya
authors: YY
authors: Wen
authors: Yan-Fang
authors: YF
authors: Li
authors: Bing
authors: B
authors: Liang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D010936:Plant Extracts