title: Pharmacokinetics of orally administered simvastatin in turkeys.
abstract: The aim of the present study was to determine the pharmacokinetics of simvastatin (SIM) administered orally in 6-week-old turkeys at a single dose of 2 mg/kg b.w. The SIM concentrations in plasma were determined by validated HPLC-MS/MS method. Mean (+/- SD; n = 10) values of pharmacokinetic parameters evaluated were as follows: Cmax = 0.49 +/- 0.21 ng/ml, t(max) = 1.6 +/- 1.1 h, AUC(0-infinity) = 1.08 +/- 0.57 h x ng/ml, t1/2kel = 2.14 +/-1.3 h and MRT = 3.08 +/- 1.52 h. The results indicate that the SIM is absorbed from the gastrointestinal tract of turkeys; however, achieved plasma level is lower compared to those observed in mammals.
authors: Departament of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland.
authors: A
authors: A
authors: Jasiecka
authors: T
authors: T
authors: Grabowski
authors: T
authors: T
authors: Maślanka
authors: H
authors: H
authors: Ziółkowski
authors: J J
authors: JJ
authors: Jaroszewski
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D005260:Female; D006207:Half-Life; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D019821:Simvastatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014422:Turkeys / Q000097:blood / Q000378:metabolism*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin