title: Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  This study evaluates the relationships between quantitative CT (QCT) and spirometric measurements of disease severity in cigarette smokers with and without chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Inspiratory and expiratory CT scans of 4062 subjects in the Genetic Epidemiology of COPD (COPDGene) Study were evaluated. Measures examined included emphysema, defined as the percentage of low-attenuation areas≤-950 HU on inspiratory CT, which we refer to as "LAA-950I"; air trapping, defined as the percentage of low-attenuation areas≤-856 HU on expiratory CT, which we refer to as "LAA-856E"; and the inner diameter, inner and outer areas, wall area, airway wall thickness, and square root of the wall area of a hypothetical airway of 10-mm internal perimeter of segmental and subsegmental airways. Correlations were determined between spirometry and several QCT measures using statistics software (SAS, version 9.2).
  
  
  RESULTS
  QCT measurements of low-attenuation areas correlate strongly and significantly (p<0.0001) with spirometry. The correlation between LAA-856E and forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) (r=-0.77 and -0.84, respectively) is stronger than the correlation between LAA-950I and FEV1 and FEV1/FVC (r=-0.67 and r=-0.76). Inspiratory and expiratory volume changes decreased with increasing disease severity, as measured by the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) staging system (p<0.0001). When airway variables were included with low-attenuation area measures in a multiple regression model, the model accounted for a statistically greater proportion of variation in FEV1 and FEV1/FVC (R2=0.72 and 0.77, respectively). Airway measurements alone are less correlated with spirometric measures of FEV1 (r=0.15 to -0.44) and FEV1/FVC (r=0.19 to -0.34).
  
  
  CONCLUSIONS
  QCT measurements are strongly associated with spirometric results showing impairment in smokers. LAA-856E strongly correlates with physiologic measurements of airway obstruction. Airway measurements can be used concurrently with QCT measures of low-attenuation areas to accurately predict lung function.
authors: Department of Radiology, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA. schroederj@njhealth.org
authors: Joyce D
authors: JD
authors: Schroeder
authors: Alexander S
authors: AS
authors: McKenzie
authors: Jordan A
authors: JA
authors: Zach
authors: Carla G
authors: CG
authors: Wilson
authors: Douglas
authors: D
authors: Curran-Everett
authors: Douglas S
authors: DS
authors: Stinson
authors: John D
authors: JD
authors: Newell
authors: David A
authors: DA
authors: Lynch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011857:Radiographic Image Interpretation, Computer-Assisted; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000503:physiopathology*; D013147:Spirometry; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014797:Vital Capacity
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