title: Control of Zn uptake in Arabidopsis halleri: a balance between Zn and Fe.
abstract: Zinc (Zn) is an essential plant micronutrient but is toxic in excess. To cope with excess Zn, plant species possess a strict metal homeostasis mechanism. The Zn hyperaccumulator Arabidopsis halleri has developed various adaptive mechanisms involving uptake, chelation, translocation and sequestration of Zn. In this mini review, we broadly discuss the different Zn tolerance mechanisms and then focus on controlled Zn uptake in A. halleri. Members of the ZRT/IRT-like protein (ZIP) family of metal transporters are mainly regulated by Zn and are involved in Zn uptake. A few members of the ZIP family, such as IRT1 and IRT2, are regulated by iron (Fe) and can transport multi-metals, including Zn, Fe, Mn, Cd, and Co. This mini-review also discusses the differential expression of multiple metal ZIP transporters in A. halleri and A. thaliana, a non-hyperaccumulator, with Zn exposure as well as Fe deficiency and their role in controlled Zn uptake and tolerance.
authors: Agricultural Biotechnology Research Center, Academia Sinica Taipei Taiwan, Republic of China.
authors: Varanavasiappan
authors: V
authors: Shanmugam
authors: Jing-Chi
authors: JC
authors: Lo
authors: Kuo-Chen
authors: KC
authors: Yeh
keywords: Arabidopsis halleri; Fe homeostasis; ZIP transporters; Zn tolerance; hyperaccumulators
references: Annu Rev Plant Biol. 2010;61:517-34
references: 20192749
references: Plant Cell. 2012 Feb;24(2):708-23
references: 22374395
references: Plant Cell. 2004 May;16(5):1327-39
references: 15100400
references: Plant J. 2004 Jan;37(2):269-81
references: 14690510
references: PLoS Genet. 2010 Apr 15;6(4):e1000911
references: 20419142
references: Biochim Biophys Acta. 2000 May 1;1465(1-2):190-8
references: 10748254
references: PLoS One. 2012;7(6):e38535
references: 22761683
references: Trends Plant Sci. 2008 May;13(5):208-15
references: 18407784
references: Environ Sci Technol. 2006 Nov 1;40(21):6792-8
references: 17144312
references: Plant Mol Biol. 1999 May;40(1):37-44
references: 10394943
references: New Phytol. 2010 Jul;187(2):368-379
references: 20487315
references: Plant Cell. 2004 Dec;16(12):3400-12
references: 15539473
references: Proc Natl Acad Sci U S A. 1996 May 28;93(11):5624-8
references: 8643627
references: Plant J. 2013 Jan;73(1):131-42
references: 22974502
references: Biochimie. 2006 Nov;88(11):1707-19
references: 16914250
references: New Phytol. 2006;172(4):646-54
references: 17096791
references: Plant Physiol. 2006 Sep;142(1):148-67
references: 16844841
references: Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7220-4
references: 9618566
references: Plant Cell Physiol. 2009 Jun;50(6):1156-70
references: 19433490
references: Science. 1998 Dec 11;282(5396):2018-22
references: 9851917
references: Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10296-301
references: 20479230
references: Plant J. 2009 Jun;58(5):737-53
references: 19207208
references: Plant Physiol. 2010 Apr;152(4):2130-41
references: 20181752
references: Plant Physiol. 2006 Nov;142(3):1127-47
references: 16998091
references: Planta. 2009 May;229(6):1171-9
references: 19252923
references: Plant Cell. 2002 Jun;14(6):1223-33
references: 12084823
references: J Exp Bot. 2013 Jan;64(1):369-81
references: 23264639
references: FEBS Lett. 2004 Oct 22;576(3):306-12
references: 15498553
references: Plant Physiol. 2012 Feb;158(2):790-800
references: 22184655
references: J Biol Chem. 2003 Nov 28;278(48):47644-53
references: 13129917
references: PLoS One. 2011 Mar 10;6(3):e17814
references: 21423774
references: Curr Opin Plant Biol. 1999 Jun;2(3):244-9
references: 10375570
references: New Phytol. 2011 Apr;190(1):125-137
references: 21219335
references: Environ Sci Technol. 1995 Jun 1;29(6):1581-5
references: 22276881
references: Plant J. 2001 Apr;26(2):181-9
references: 11389759
references: Plant Cell. 2002 Jun;14(6):1347-57
references: 12084831
references: Cell Res. 2008 Mar;18(3):385-97
references: 18268542
references: Plant Cell Physiol. 2004 Dec;45(12):1749-58
references: 15653794
references: Nature. 2008 May 15;453(7193):391-5
references: 18425111
references: Plant J. 2009 Mar;57(6):1116-27
references: 19054361
references: J Exp Bot. 2010 Jun;61(11):3057-67
references: 20484319
references: New Phytol. 2002 Jul;155(1):47-57
references: 33873296
references: Plant J. 2004 Jan;37(2):251-68
references: 14690509
references: PLoS Genet. 2012;8(12):e1003120
references: 23236296
references: Plant Mol Biol. 2004 Feb;54(3):373-85
references: 15284493
references: Planta. 2000 Dec;212(1):75-84
references: 11219586
references: Plant Physiol. 2004 Feb;134(2):716-25
references: 14730081
references: New Phytol. 2009;182(2):392-404
references: 19210716
references: New Phytol. 2009 Mar;181(4):759-776
references: 19192189
references: Nature. 1988 May 12;333(6169):134-9
references: 3285219
references: Plant J. 2004 Aug;39(3):425-39
references: 15255871
references: Plant Physiol. 2011 Apr;155(4):1893-907
references: 21325567