title: Novel Clonal t(2;4) (q23;p14) Secondary Cytogenetic Abnormality in a Primary Myxoid Liposarcoma.
abstract: Myxoid liposarcomas are malignant lipomatous tumors with a predilection for young adults. They are characterized by the presence of reciprocal translocation between the CHOP (DDIT3) gene on chromosome 12 and the FUS gene on chromosome 16, t(12;16)(q13;p11.2) in >95% of cases, or less commonly, a translocation between the DDIT3 and EWSR1 genes, t(12;22)(q13;q12). Secondary aberrations involving trisomy 8 and chromosomes 1 and 16 have been reported. Herein, we report for the first time a novel secondary clonal translocation, t(2;4) (q23;p14) in addition to t(12;16)(q13; p11.2) in a 30-year-old woman with myxoid liposarcoma on the left posterior thigh region without any prior chemoradiation therapy. The significance of this translocation remains to be established.
authors: *Department of Oral and Maxillofacial Surgery, Anesthesiology and Oral Pathology, College of Dentistry Departments of †Pathology and Laboratory Medicine ‡Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, OH.
authors: Amber
authors: A
authors: Kiyani
authors: Nyla A
authors: NA
authors: Heerema
authors: Joel L
authors: JL
authors: Mayerson
authors: Thomas J
authors: TJ
authors: Scharschmidt
authors: Obiajulu H
authors: OH
authors: Iwenofu
mesh_terms: D000328:Adult; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000235:genetics*; D014178:Translocation, Genetic