title: Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons.
abstract: Restriction of food intake increases the acquisition of drug abuse behavior and enhances the reinforcing efficacy of those drugs. However, the neurophysiological mechanisms responsible for the interactions between feeding state and drug use are largely unknown. Here we show that chronic mild food restriction increases the burst firing of dopamine neurons in the substantia nigra. Dopamine neurons from food-restricted mice exhibited increased burst firing in vivo, an effect that was enhanced by an injection of the psychomotor stimulant cocaine (10 mg/kg, i.p.). Food restriction also enhanced aspartic acid-induced burst firing of dopamine neurons in an ex vivo brain slice preparation, consistent with an adaptation occurring in the somatodendritic compartment and independent of a circuit mechanism. Enhanced burst firing persisted after 10 d of free feeding following chronic food restriction but was not observed following a single overnight fast. Whole-cell patch-clamp recordings indicated that food restriction also increased electrically evoked AMPAR/NMDAR ratios and increased D2 autoreceptor-mediated desensitization in dopamine neurons. These results identify dopamine neurons in the substantia nigra as a convergence point for the interactions between feeding state and drugs of abuse. Furthermore, increased glutamate transmission combined with decreased autoreceptor inhibition could work in concert to enhance drug efficacy in response to food restriction.
authors: Department of Physiology, University of Texas Health Science Center, San Antonio, TX, USA.
authors: Sarah Y
authors: SY
authors: Branch
authors: R Brandon
authors: RB
authors: Goertz
authors: Amanda L
authors: AL
authors: Sharpe
authors: Janie
authors: J
authors: Pierce
authors: Sudip
authors: S
authors: Roy
authors: Daijin
authors: D
authors: Ko
authors: Carlos A
authors: CA
authors: Paladini
authors: Michael J
authors: MJ
authors: Beckstead
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D001703:Biophysics; D001921:Brain / Q000166:cytology*; D004298:Dopamine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D059290:Dopaminergic Neurons / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D005508:Food Deprivation / Q000502:physiology*; D066298:In Vitro Techniques; D007478:Iontophoresis / Q000379:methods; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D017470:Receptors, Glutamate / Q000378:metabolism*
chemical_list: D015259:Dopamine Agents; D018683:Excitatory Amino Acid Agents; D017470:Receptors, Glutamate; D001224:Aspartic Acid; D004298:Dopamine
references: Eur J Neurosci. 2006 Jan;23(1):180-6
references: 16420427
references: Eur J Pharmacol. 2003 Nov 7;480(1-3):97-115
references: 14623354
references: Synapse. 2008 Sep;62(9):637-42
references: 18563836
references: Science. 2004 Mar 26;303(5666):2040-2
references: 15044807
references: J Pharmacol Exp Ther. 1989 Dec;251(3):833-9
references: 2557418
references: J Pharmacol Exp Ther. 2009 Apr;329(1):342-9
references: 19122113
references: Psychopharmacology (Berl). 2003 Jul;168(1-2):170-176
references: 12845419
references: Front Syst Neurosci. 2011 May 10;5:25
references: 21617731
references: Drug Alcohol Depend. 1987 Jan;19(1):17-27
references: 3816536
references: Neuroscience. 1994 Oct;62(3):641-5
references: 7870295
references: CNS Neurol Disord Drug Targets. 2006 Feb;5(1):79-97
references: 16613555
references: Psychopharmacology (Berl). 2003 Jul;168(1-2):84-98
references: 12721782
references: J Neurosci. 2006 Mar 8;26(10):2788-97
references: 16525058
references: Naunyn Schmiedebergs Arch Pharmacol. 1994 Mar;349(3):230-5
references: 8208301
references: Curr Opin Pharmacol. 2009 Feb;9(1):53-8
references: 19138563
references: Curr Drug Abuse Rev. 2009 May;2(2):195-213
references: 19630749
references: Psychopharmacology (Berl). 2001 Apr;154(4):420-8
references: 11349397
references: Psychopharmacology (Berl). 2000 Jun;150(3):337-46
references: 10923762
references: Neuroscience. 2007 Feb 9;144(3):1067-74
references: 17156935
references: Neurochem Int. 2002 Nov;41(5):333-40
references: 12176075
references: Brain Res. 1975 Jan 17;83(3):531-7
references: 1111820
references: Nature. 2003 Apr 10;422(6932):614-8
references: 12687000
references: Nature. 1976 Mar 18;260(5548):258-60
references: 1256567
references: Science. 2008 Sep 19;321(5896):1690-2
references: 18802002
references: Nat Rev Neurosci. 2004 Jun;5(6):483-94
references: 15152198
references: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7281-8
references: 19342487
references: Physiol Behav. 2002 Jul;76(3):353-64
references: 12117572
references: Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8
references: 2899326
references: J Neurosci. 2009 Dec 9;29(49):15531-41
references: 20007477
references: Neuron. 2008 Jul 31;59(2):288-97
references: 18667156
references: J Neurosci. 1984 Nov;4(11):2877-90
references: 6150071
references: J Neurophysiol. 2012 Aug 1;108(3):802-9
references: 22592307
references: J Neurosci Methods. 2012 Oct 15;211(1):145-58
references: 22939922
references: Neuron. 2004 Jun 24;42(6):939-46
references: 15207238
references: Biol Psychiatry. 2009 Oct 15;66(8):801-3
references: 19539267
references: Brain Res Brain Res Rev. 1997 Dec;25(3):312-34
references: 9495561
references: J Neurosci. 2004 Aug 25;24(34):7482-90
references: 15329395
references: Science. 1979 Jul 20;205(4403):319-21
references: 36665
references: J Neurosci. 2002 May 1;22(9):3404-13
references: 11978817
references: J Neurosci. 2004 Feb 11;24(6):1265-71
references: 14960596
references: J Neurochem. 1991 Mar;56(3):961-7
references: 1993900
references: J Neurosci. 2002 Apr 1;22(7):2977-88
references: 11923462
references: Brain Res. 2006 Apr 12;1082(1):98-101
references: 16516172
references: Annu Rev Psychol. 2006;57:87-115
references: 16318590
references: Neuropsychopharmacology. 2009 Jul;34(8):1926-35
references: 19279570
references: Neuroscience. 1988 Jan;24(1):19-28
references: 3368048
references: Exp Clin Psychopharmacol. 1999 Nov;7(4):324-37
references: 10609967
references: Behav Neurosci. 2008 Dec;122(6):1257-63
references: 19045945
references: Pharmacol Biochem Behav. 1981 Jul;15(1):141-4
references: 7291222
references: Drug Alcohol Depend. 1985 Nov;16(2):95-109
references: 4075974
references: J Neurosci. 1995 Nov;15(11):7189-95
references: 7472473
references: J Neurosci. 2007 Feb 21;27(8):2074-80
references: 17314302
references: CNS Neurol Disord Drug Targets. 2006 Feb;5(1):99-108
references: 16613556
references: J Neurosci. 2000 Dec 1;20(23):8876-85
references: 11102497
references: Nat Neurosci. 2011 Jul 10;14(8):1033-8
references: 21743470
references: Eur J Pharmacol. 2008 Sep 11;592(1-3):109-15
references: 18652823
references: Neuroscience. 1992 Jul;49(1):63-72
references: 1357587
references: J Pharmacol Exp Ther. 1994 Dec;271(3):1181-92
references: 7996424
references: Nature. 2001 May 31;411(6837):583-7
references: 11385572
references: Neuron. 2001 Jun;30(3):819-28
references: 11430814
references: Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8858-63
references: 16723393
references: J Neurosci. 1995 Oct;15(10):6640-50
references: 7472425
references: Neuron. 2002 Oct 10;36(2):241-63
references: 12383780
references: Eur J Neurosci. 2003 Oct;18(8):2326-34
references: 14622194
references: Brain Res. 2005 Nov 9;1061(2):88-96
references: 16226228
references: J Neurosci. 2007 Apr 25;27(17):4776-85
references: 17460090
references: J Physiol. 1987 Nov;392:397-416
references: 2451725
references: Synapse. 2002 Nov;46(2):83-90
references: 12211086
references: Eur J Neurosci. 2011 Dec;34(12):1997-2006
references: 22122410
references: Neuroscience. 2003;119(4):1157-67
references: 12831870