title: Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans.
abstract: BACKGROUND
  Diets enriched with sphingolipids may improve blood lipid profiles. Studies in animals have shown reductions in cholesterol absorption and alterations in blood lipids after treatment with sphingomyelin (SM). However, minimal information exists on effect of SM on cholesterol absorption and metabolism in humans. The objective was to assess the effect of SM consumption on serum lipid concentrations and cholesterol metabolism in healthy humans.
  
  
  METHODS
  Ten healthy adult males and females completed a randomized crossover study. Subjects consumed controlled diets with or without 1 g/day SM for 14 days separated by at least 4 week washout period. Serum lipid profile and markers of cholesterol metabolism including cholesterol absorption and synthesis were analyzed.
  
  
  RESULTS
  Serum triglycerides, total, LDL- and VLDL- cholesterol were not affected while HDL cholesterol concentrations were increased (p = 0.043) by SM diet consumption. No change in cholesterol absorption and cholesterol fractional synthesis rate was observed with supplementation of SM compared to control. Intraluminal cholesterol solubilization was also not affected by consumption of SM enriched diet.
  
  
  CONCLUSIONS
  In humans, 1 g/day of dietary SM does not alter the blood lipid profile except for an increased HDL-cholesterol concentration and has no effect on cholesterol absorption, synthesis and intraluminal solubilization compared to control.
  
  
  BACKGROUND
  Clinicaltrials.gov # NCT00328211.
authors: Vanu R
authors: VR
authors: Ramprasath
authors: Peter Jh
authors: PJ
authors: Jones
authors: Donna D
authors: DD
authors: Buckley
authors: Laura A
authors: LA
authors: Woollett
authors: James E
authors: JE
authors: Heubi
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D013109:Sphingomyelins / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D013109:Sphingomyelins; D014280:Triglycerides; D002784:Cholesterol
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