title: [Animal experimental study of biodegradable magnesium alloy stapler for gastrointestinal anastomosis].
abstract: OBJECTIVE
  To explore the safety and feasibility of biodegradable magnesium alloy stapler based on the result of animal experimental study for gastrointestinal anastomosis.
  
  
  METHODS
  Sixteen beagle dogs were equally and randomly divided into experimental (magnesium alloy) group and control (titanium alloy) group. A gastrojejunal and a colonic anastomosis were performed in each beagle dog. The anastomosis time, postoperative complications, body weight, blasting pressure of anastomosis and serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, creatinine, blood urea nitrogen, and serum magnesium were compared between the two groups. The healing of anastomosis and degradation of magnesium alloy were observed. The histopathological features of heart, liver, spleen and kidney were examined in the two groups.
  
  
  RESULTS
  There were no significant differences in anastomosis time, body weight, postoperative complications, anastomotic bursting pressure between the two groups. The anastomosis was healed well, and no dramatic inflammatory cell infiltration was observed. Magnesium alloy could be degraded completely in the animal body within 90 days. There were no significant differences in serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, creatinine, blood urea nitrogen and serum magnesium between the two groups. Histopathological examination showed that the degradation of magnesium alloy did not harm the important organs (liver, kidney, heart, brain and spleen).
  
  
  CONCLUSIONS
  Magnesium alloy stapler is safe and feasible for gastrointestinal anastomosis in beagle dogs. The degradation of magnesium alloy does not harm the healing of anastomosis and other important organs. Magnesium alloy stapler may be a candidate of biodegradable and safe material of stapler for gastrointestinal anastomosis in human.
authors: Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing 100044, China. yjye101@yahoo.com.cn; shwang60@sina.com.
authors: Jian
authors: J
authors: Cao
authors: Ke-wei
authors: KW
authors: Jiang
authors: Xiao-dong
authors: XD
authors: Yang
authors: Zhan-long
authors: ZL
authors: Shen
authors: Peng
authors: P
authors: Guo
authors: Yi-chao
authors: YC
authors: Yan
authors: Yan-cheng
authors: YC
authors: Cui
authors: Long
authors: L
authors: Han
authors: You
authors: Y
authors: Lv
authors: Ying-jiang
authors: YJ
authors: Ye
authors: Shan
authors: S
authors: Wang
mesh_terms: D020341:Absorbable Implants; D000497:Alloys; D000818:Animals; D004285:Dogs; D005260:Female; D005763:Gastroenterostomy / Q000295:instrumentation*; D008274:Magnesium; D008297:Male; D013537:Sutures; D014025:Titanium
chemical_list: D000497:Alloys; D014025:Titanium; D008274:Magnesium