title: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
abstract: Measurement of vessel caliber by magnetic resonance imaging (MRI) is a valuable technique for in vivo monitoring of hemodynamic status and vascular development, especially in the brain. Here, we introduce a new paradigm in MRI termed vessel architectural imaging (VAI) that exploits an overlooked temporal shift in the magnetic resonance signal, forming the basis for vessel caliber estimation, and show how this phenomenon can reveal new information on vessel type and function not assessed by any other noninvasive imaging technique. We also show how this biomarker can provide new biological insights into the treatment of patients with cancer. As an example, we demonstrate using VAI that anti-angiogenic therapy can improve microcirculation and oxygen saturation and reduce vessel calibers in patients with recurrent glioblastomas and, more crucially, that patients with these responses have prolonged survival. Thus, VAI has the potential to identify patients who would benefit from therapies.
authors: 1] Department of Radiology and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] The Intervention Centre, Oslo University Hospital, Oslo, Norway.
authors: Kyrre E
authors: KE
authors: Emblem
authors: Kim
authors: K
authors: Mouridsen
authors: Atle
authors: A
authors: Bjornerud
authors: Christian T
authors: CT
authors: Farrar
authors: Dominique
authors: D
authors: Jennings
authors: Ronald J H
authors: RJ
authors: Borra
authors: Patrick Y
authors: PY
authors: Wen
authors: Percy
authors: P
authors: Ivy
authors: Tracy T
authors: TT
authors: Batchelor
authors: Bruce R
authors: BR
authors: Rosen
authors: Rakesh K
authors: RK
authors: Jain
authors: A Gregory
authors: AG
authors: Sorensen
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers; D001808:Blood Vessels / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D005909:Glioblastoma / Q000098:blood supply* / Q000188:drug therapy; D006801:Humans; D018810:Magnetic Resonance Angiography; D008833:Microcirculation / Q000187:drug effects; D011799:Quinazolines / Q000627:therapeutic use; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D007211:Indoles
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D015415:Biomarkers; D011799:Quinazolines; D040262:Receptors, Vascular Endothelial Growth Factor; C500926:cediranib; D007211:Indoles
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