title: Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.
abstract: To investigate the prognostic role of major matrix metalloproteinase (MMP) gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated with chemoradiotherapy. Four hundred twenty-one consecutive NPC patients were prospectively recruited. Two hundred patients were randomly selected as the training cohort, and the remaining 221 patients were the validation cohort. Twelve polymorphisms in the MMP-1, 2, 3, 7, 8, and 9 genes were genotyped by ligase detection reaction-PCR. MMP-9 rs2250889 PR/RR (HR = 2.287, 95% CI 1.400-3.735) and rs17576 RQ/QQ (HR = 2.347, 95% CI 1.431-3.849) genotypes were significantly related with increased death risk in the training cohort. Analysis of the validation cohort confirmed these results (rs2250889: HR = 2.231, 95% CI 1.281-3.886; rs17576: HR = 2.987, 95% CI 1.674-5.330). Multivariate analysis showed that rs17576 (HR = 2.284, 95% CI 1.123-4.643, P = 0.023) was still an independent prognostic factor. The MMP-9 rs17576 is a novel independent prognostic marker in patients with locoregionally advanced NPC treated with chemoradiotherapy.
authors: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
authors: Huai
authors: H
authors: Liu
authors: Pei-Yu
authors: PY
authors: Huang
authors: Lin-Quan
authors: LQ
authors: Tang
authors: Qiu-Yan
authors: QY
authors: Chen
authors: Ying
authors: Y
authors: Zhang
authors: Lu
authors: L
authors: Zhang
authors: Ling
authors: L
authors: Guo
authors: Dong-Hua
authors: DH
authors: Luo
authors: Hao-Yuan
authors: HY
authors: Mo
authors: Yan-Qun
authors: YQ
authors: Xiang
authors: Fang
authors: F
authors: Qiu
authors: Rui
authors: R
authors: Sun
authors: Ming-Yuan
authors: MY
authors: Chen
authors: Yi-Jun
authors: YJ
authors: Hua
authors: Xing
authors: X
authors: Lv
authors: Lin
authors: L
authors: Wang
authors: Chong
authors: C
authors: Zhao
authors: Xiang
authors: X
authors: Guo
authors: Ka-Jia
authors: KJ
authors: Cao
authors: Chao-Nan
authors: CN
authors: Qian
authors: Ming-Huang
authors: MH
authors: Hong
authors: Hai-Qiang
authors: HQ
authors: Mai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D002277:Carcinoma; D059248:Chemoradiotherapy; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000628:therapy*; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D020780:Matrix Metalloproteinase 9
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