title: Lipids of Candida albicans and their role in multidrug resistance.
abstract: Over the years, lipids of non-pathogenic yeast such as Saccharomyces cerevisiae have been characterized to some details; however, a comparable situation does not exist for the human pathogenic fungi. This review is an attempt to bring in recent advances made in lipid research by employing high throughput lipidomic methods in terms of lipid analysis of pathogenic yeasts. Several pathogenic fungi exhibit multidrug resistance (MDR) which they acquire during the course of a treatment. Among the several causal factors, lipids by far have emerged as one of the critical contributors in the MDR acquisition in human pathogenic Candida. In this article, we have particularly focused on the role of lipids involved in cross talks between different cellular circuits that impact the acquisition of MDR in Candida.
authors: Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India, rp47@mail.jnu.ac.in.
authors: Rajendra
authors: R
authors: Prasad
authors: Ashutosh
authors: A
authors: Singh
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry* / Q000378:metabolism; D001393:Azoles / Q000378:metabolism*; D002176:Candida albicans / Q000737:chemistry* / Q000502:physiology; D018432:Drug Resistance, Multiple / Q000502:physiology*; D004875:Ergosterol / Q000378:metabolism; D057166:High-Throughput Screening Assays / Q000379:methods; D008055:Lipids / Q000032:analysis*; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D020239:Receptor Cross-Talk / Q000502:physiology; D013107:Sphingolipids / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D001393:Azoles; D008055:Lipids; D013107:Sphingolipids; D004875:Ergosterol
references: Biochim Biophys Acta. 2012 Aug;1821(8):1068-77
references: 22234261
references: FEMS Microbiol Lett. 2000 Apr 1;185(1):59-63
references: 10731607
references: J Antimicrob Chemother. 2005 Sep;56 Suppl 1:i5-i11
references: 16120635
references: BMC Genomics. 2012 Aug 16;13:396
references: 22897889
references: Microbiology (Reading). 2007 Aug;153(Pt 8):2373-2385
references: 17660402
references: Cell. 1996 Nov 1;87(3):507-17
references: 8898203
references: Curr Genet. 1995 Mar;27(4):320-9
references: 7614555
references: Mol Biol Cell. 2005 Feb;16(2):665-75
references: 15563612
references: J Biol Chem. 2007 Jan 12;282(2):821-5
references: 17130120
references: Biol Pharm Bull. 2006 Aug;29(8):1542-6
references: 16880601
references: Am J Med. 2012 Jan;125(1 Suppl):S3-13
references: 22196207
references: Biochemistry. 2006 Feb 21;45(7):2425-35
references: 16475832
references: Biochim Biophys Acta. 2009 May;1794(5):852-9
references: 19150512
references: Antimicrob Agents Chemother. 2008 Feb;52(2):694-704
references: 18056285
references: Mol Biol Cell. 2010 Feb 1;21(3):443-55
references: 20016005
references: J Mol Microbiol Biotechnol. 2005;9(1):3-15
references: 16254441
references: Nat Rev Drug Discov. 2005 Jul;4(7):594-610
references: 16052242
references: Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
references: 18216768
references: Annu Rev Microbiol. 2012;66:39-63
references: 22703054
references: Clin Microbiol Rev. 2007 Jan;20(1):133-63
references: 17223626
references: Nat Rev Mol Cell Biol. 2010 Aug;11(8):593-8
references: 20606693
references: Microbiology (Reading). 2011 Nov;157(Pt 11):3232-3242
references: 21903752
references: J Mycol Med. 2012 Jun;22(2):173-8
references: 23518020
references: Cold Spring Harb Perspect Biol. 2011 Oct 01;3(10):a004697
references: 21628426
references: Antimicrob Agents Chemother. 2005 Aug;49(8):3442-52
references: 16048959
references: Methods Mol Biol. 2013;968:1-23
references: 23296882
references: OMICS. 2010 Dec;14(6):665-77
references: 20726778
references: Biochem Soc Trans. 2005 Nov;33(Pt 5):1219-23
references: 16246085
references: Nat Rev Mol Cell Biol. 2005 Mar;6(3):209-20
references: 15738987
references: Eukaryot Cell. 2011 Nov;10(11):1376-83
references: 21926328
references: Infect Immun. 2007 May;75(5):2612-20
references: 17339351
references: Antimicrob Agents Chemother. 2004 May;48(5):1778-87
references: 15105135
references: Traffic. 2011 Sep;12(9):1257-68
references: 21649806
references: Prog Lipid Res. 2000 May;39(3):257-88
references: 10799718
references: Mol Microbiol. 2010 Mar;75(5):1112-32
references: 20132453
references: Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents
references: 19366916
references: Int Rev Cytol. 2005;242:215-48
references: 15598470
references: Fungal Genet Biol. 2010 Feb;47(2):94-106
references: 19665571
references: J Biol Chem. 2007 Jun 1;282(22):15946-53
references: 17426021
references: Fungal Biol Rev. 2011 Mar 1;25(1):48-60
references: 21528015
references: OMICS. 2013 Feb;17(2):84-93
references: 23374108
references: Cell Mol Life Sci. 2006 Dec;63(24):2908-21
references: 17103115
references: J Biol Chem. 2010 Nov 12;285(46):35792-802
references: 20826817
references: J Antimicrob Chemother. 2005 Jun;55(6):905-13
references: 15845783
references: PLoS One. 2011 Apr 29;6(4):e19266
references: 21559392
references: J Gen Microbiol. 1986 Sep;132(9):2421-31
references: 3540203
references: BMC Genomics. 2008 Dec 03;9:579
references: 19055746
references: Mol Cell Biol. 2008 Oct;28(19):5851-64
references: 18644857
references: Nat Genet. 2010 Jul;42(7):590-8
references: 20543849
references: Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2136-41
references: 19174513
references: Odontology. 2010 Feb;98(1):15-25
references: 20155503
references: Yeast. 2002 Mar 15;19(4):303-18
references: 11870854
references: Infect Immun. 2003 Aug;71(8):4333-40
references: 12874310
references: PLoS One. 2012;7(6):e39812
references: 22761908
references: PLoS Pathog. 2010 Jun 03;6(6):e1000939
references: 20532216