title: [H. pylori genomics].
abstract: Helicobacter pylori, a major stomach pathogen associated with gastritis, gastric/duodenal ulcer, gastric cancer and other diseases, shows extreme diversity at the genome sequence level. It is now possible to sequence whole genomes of Japanese isolates at a reasonable cost. Here I summarize what has been learned from analyzing whole H. pylori genomes. Emphasis is placed on features of East Asian strains, genome dynamics and epigenetics. I cover both long-term evolution with us Homo sapiens and short-term evolution within our bodies. I hope this guide will be helpful for decoding and analyzing H. pylori genomes of clinical isolates, especially those from Japan and other East Asian countries.
authors: Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo.
authors: Ichizo
authors: I
authors: Kobayashi
mesh_terms: D014644:Genetic Variation / Q000235:genetics*; D023281:Genomics; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D010802:Phylogeny; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics