title: The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome.
abstract: Fat accumulation is associated with the release of many novel adipokines such as retinol-binding protein 4 and fatty acid-binding protein 4. These adipokines have been linked to insulin resistance, metabolic syndrome, type 2 diabetes and cardiovascular disease. Since weight loss is the first step for the treatment of metabolic syndrome, which increases the risks for both type 2 diabetes and cardiovascular disease, we have investigated the effects of weight loss on serum retinol-binding protein 4 and fatty acid-binding protein 4 in obese individuals with this syndrome. Twenty-nine obese female subjects with metabolic syndrome, aged 18-62 years completed a 2-month weight loss diet plan. Data were collected from dual-energy X-ray absorptiometry and indirect calorimetry. Blood was taken at baseline and at 2 months and assayed for adipokines, lipids, and insulin resistance parameters. The change in circulating fatty acid-binding protein 4 levels were inversely correlated with total weight loss (p<0.02) and lean mass loss (p<0.01), but not with fat mass loss. Retinol-binding protein 4 levels did not track with any measure of body composition. Changes in leptin levels were found to correlate with weight loss (p<0.02), fat loss (p<0.03), and lean mass loss (p<0.05). Fatty acid-binding protein 4 levels increased and retinol-binding protein 4 levels did not change during moderate weight loss in obese women with metabolic syndrome; however, several other risk factors for type 2 diabetes and cardiovascular disease did improve with weight loss.
authors: Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The University of California at Davis Medical Center, Sacramento, CA, USA.
authors: K B
authors: KB
authors: Comerford
authors: Family and Consumer Sciences Department, California State University Sacramento, Sacramento, CA, USA.
authors: W
authors: W
authors: Buchan
authors: Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The University of California at Davis Medical Center, Sacramento, CA, USA.
authors: S E
authors: SE
authors: Karakas
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism*; D009765:Obesity / Q000150:complications* / Q000378:metabolism*; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma