title: Secondary cell reprogramming systems: as years go by.
abstract: The groundbreaking discovery of the induced pluripotent stem cells in 2006 brought a major paradigm shift in our understanding of the plasticity of differentiated cells. An unprecedented effort has been invested to elucidate the underpinning molecular mechanisms of the dramatic changes in cell properties, using the powerful secondary reprogramming systems (2°RS). This review outlines the key components of the 2°RS, its recent development and applications that have led to a deeper understanding of the 'magic' of induced cell fate changes.
authors: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario M5T 3H7, Canada; Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada. Electronic address: nagy@lunenfeld.ca.
authors: Andras
authors: A
authors: Nagy
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D065150:Cellular Reprogramming / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice