title: Inhibitors of influenza viruses replication: a patent evaluation (WO2013019828).
abstract: A series of compounds incorporating two aromatic heterocycles were prepared as inhibitors of influenza virus replication in the patent. Some of them presented potent activity against influenza virus in Madin-Darby canine kidney (MDCK) cells and in influenza therapeutic mouse model. These compounds in the patent were also defined to be pharmaceutically acceptable salts and pharmaceutical compositions that were claimed to be useful for treating influenza. In view of the threat of influenza pandemic, it is necessary to discover new anti-influenza drugs. Although there is a lack of essential biological data and the molecular mechanisms are not clear, these compounds with potent antiviral activity stand for a new type of anti-influenza agents and deserve further studies.
authors: Shandong University, School of Pharmaceutical Sciences, Department of Medicinal Chemistry , 44, West Culture Road, Jinan, Shandong 250012, P. R. China +86 531 88382264 ; +86 531 88382264 ; wenfxu@gmail.com.
authors: Yuanchao
authors: Y
authors: Xie
authors: Weiguo
authors: W
authors: Song
authors: Weidong
authors: W
authors: Xiao
authors: Changjuan
authors: C
authors: Gu
authors: Wenfang
authors: W
authors: Xu
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D015195:Drug Design; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000187:drug effects; D006801:Humans; D007252:Influenza Vaccines / Q000627:therapeutic use; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D051379:Mice; D019384:Nucleic Acid Synthesis Inhibitors; D009975:Orthomyxoviridae / Q000187:drug effects*; D010330:Patents as Topic; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D019384:Nucleic Acid Synthesis Inhibitors