title: Tetraphenylethene-based aggregation-induced emission fluorescent organic nanoparticles: facile preparation and cell imaging application.
abstract: Tetraphenylethene-based (TPE) aggregation-induced emission fluorescent organic nanoparticles (FONs) were facilely prepared via Schiff base condensation with ɛ-polylysine (Ply) and subsequent reduction to form stable CN covalent bond. Thus obtained TPE-Ply FONs were characterized by a series of techniques including fluorescent spectroscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of TPE-Ply FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, intense fluorescence, uniform morphology (100-200nm) and excellent biocompatibility, making them promising for cell imaging application.
authors: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, PR China. Electronic address: sychyzhang@126.com.
authors: Xiqi
authors: X
authors: Zhang
authors: Meiying
authors: M
authors: Liu
authors: Bin
authors: B
authors: Yang
authors: Xiaoyong
authors: X
authors: Zhang
authors: Yen
authors: Y
authors: Wei
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry / Q000633:toxicity; D001672:Biocompatible Materials / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005030:Ethylenes / Q000737:chemistry / Q000633:toxicity; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D008422:Materials Testing; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D055620:Optical Phenomena; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001555:Benzene Derivatives; D001672:Biocompatible Materials; D005030:Ethylenes; D005456:Fluorescent Dyes
keywords: Aggregation-induced emission; Cell imaging; Fluorescent organic nanoparticles; Schiff base condensation; ɛ-Polylysine