title: Role of the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639G>A gene polymorphism in patients with retinal vein occlusion.
abstract: OBJECTIVE
  Retinal vein occlusion (RVO) is a major vision-threatening disease. Vitamin K epoxide reductase recycles reduced vitamin K, which is essential for the gamma carboxylation of clotting factors II, VII, IX, X and proteins C and S. Recently, the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639G>A (rs9923231) polymorphism has been reported as a novel risk factor for RVO in a Turkish population. The present study was set to confirm or to refute this association in a larger cohort of patients with RVO.
  
  
  METHODS
  The present case-control study comprised 285 patients with central RVO, 401 patients with branch RVO and 333 control subjects. Genotypes of the VKORC1 -1639G>A polymorphism were determined by 5' exonuclease assay (TaqMan).
  
  
  RESULTS
  No significant differences in either genotype distributions or allele frequencies of the vitamin K epoxide reductase complex subunit 1 -1639G>A polymorphism were found between patients and control subjects (p > 0.05). In a logistic regression analysis neither branch nor central RVO was predicted by the vitamin K epoxide reductase complex subunit 1 -1639G>A genotypes, but by arterial hypertension, ever-smoking status and in case of central RVO additionally by diabetes mellitus.
  
  
  CONCLUSIONS
  Our data suggest that the vitamin K epoxide reductase complex subunit 1 -1639G>A gene polymorphism is unlikely a major risk factor for patients with either central or branch RVO.
authors: Department of Ophthalmology, Medical University of Graz , Austria .
authors: Martin
authors: M
authors: Weger
authors: Iris
authors: I
authors: Steinbrugger
authors: Wilfried
authors: W
authors: Renner
authors: Eva Maria
authors: EM
authors: Pöschl
authors: Tobias
authors: T
authors: Brockmann
authors: Dieter Franz
authors: DF
authors: Rabensteiner
authors: Yosuf
authors: Y
authors: El-Shabrawi
authors: Anton
authors: A
authors: Haas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012170:Retinal Vein Occlusion / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D012307:Risk Factors; D014812:Vitamin K / Q000378:metabolism; D064417:Vitamin K Epoxide Reductases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014812:Vitamin K; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases