title: Preoperative long-acting octreotide treatment for invasive thyrotropin-secreting pituitary macroadenoma after previous radioiodine thyroid ablation.
abstract: We report a 33-year-old woman with invasive thyrotropin-secreting pituitary adenoma after previous thyroid ablation with radioiodine who was successfully treated with transsphenoidal surgery after pre-treatment with octreotide-LAR for 10 months. Since invasive and aggressive thyrotropin-secreting macroadenomas are more frequently observed in patients who have undergone thyroid ablation, we suggest preoperative treatment with somatostatin analogs should be considered in these patients to reduce serum thyrotropin and stabilize or reduce tumor size.
authors: Department of Endocrinology, Medical University of Lodz, 1/3 Sterling Street, 91-425 Lodz, Poland. Electronic address: anna.gruszka@umed.lodz.pl.
authors: Anna
authors: A
authors: Gruszka
authors: Department of Neurosurgery, Military Institute of Medicine, Warsaw, Poland.
authors: Grzegorz M
authors: GM
authors: Zielinski
authors: Department of Endocrinology, Medical University of Lodz, 1/3 Sterling Street, 91-425 Lodz, Poland.
authors: Jolanta
authors: J
authors: Kunert-Radek
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006111:Graves Disease / Q000532:radiotherapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects*; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007457:Iodine Radioisotopes; D013972:Thyrotropin; D015282:Octreotide
keywords: Octreotide; Somatostatin analogs; TSH-secreting pituitary tumor; Thyrotropinoma