title: A Central role for mTOR in lipid homeostasis.
abstract: The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.
authors: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
authors: Dudley W
authors: DW
authors: Lamming
authors: David M
authors: DM
authors: Sabatini
mesh_terms: D050156:Adipogenesis; D000273:Adipose Tissue / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D050155:Lipogenesis; D008066:Lipolysis; D008099:Liver / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases
references: Cell. 2012 Apr 13;149(2):274-93
references: 22500797
references: Front Genet. 2012 Sep 11;3:177
references: 22973301
references: Cell Metab. 2012 Aug 8;16(2):202-12
references: 22883231
references: Nature. 2010 Dec 23;468(7327):1100-4
references: 21179166
references: Diabetes. 2010 Jun;59(6):1397-406
references: 20332342
references: Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16184-9
references: 22927400
references: J Biol Chem. 2012 Aug 24;287(35):29579-88
references: 22773877
references: Mol Cell. 2010 Jul 30;39(2):171-83
references: 20670887
references: Cell Metab. 2012 May 2;15(5):725-38
references: 22521878
references: Cell Metab. 2011 Jul 6;14(1):21-32
references: 21723501
references: PLoS Biol. 2009 Mar 3;7(3):e60
references: 19260765
references: Cell Metab. 2008 Sep;8(3):224-36
references: 18762023
references: Science. 2012 Mar 30;335(6076):1638-43
references: 22461615
references: Sci Signal. 2013 Jan 08;6(257):ra2
references: 23300339
references: Cell Metab. 2008 Nov;8(5):411-24
references: 19046572
references: Cell Metab. 2008 Nov;8(5):399-410
references: 19046571
references: PLoS One. 2009 Jul 10;4(7):e6189
references: 19593385
references: Mol Cell Biol. 2008 Jan;28(1):61-70
references: 17967879
references: Dev Cell. 2010 May 18;18(5):763-74
references: 20493810
references: Genes Dev. 2009 Feb 15;23(4):496-511
references: 19240135
references: J Clin Invest. 2013 Mar;123(3):980-9
references: 23454761
references: Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9902-7
references: 19497867
references: Cell. 2011 Aug 5;146(3):408-20
references: 21816276
references: Cell. 2009 May 29;137(5):873-86
references: 19446321
references: Hepatology. 2012 Jun;55(6):1727-37
references: 22183976