title: Changes in effective connectivity by propofol sedation.
abstract: Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices.
authors: Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Liège, Belgium.
authors: Francisco
authors: F
authors: Gómez
authors: Christophe
authors: C
authors: Phillips
authors: Andrea
authors: A
authors: Soddu
authors: Melanie
authors: M
authors: Boly
authors: Pierre
authors: P
authors: Boveroux
authors: Audrey
authors: A
authors: Vanhaudenhuyse
authors: Marie-Aurélie
authors: MA
authors: Bruno
authors: Olivia
authors: O
authors: Gosseries
authors: Vincent
authors: V
authors: Bonhomme
authors: Steven
authors: S
authors: Laureys
authors: Quentin
authors: Q
authors: Noirhomme
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000758:Anesthesia; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D001303:Auditory Cortex / Q000187:drug effects* / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D001499:Bayes Theorem; D001931:Brain Mapping; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009294:Narcotics / Q000008:administration & dosage*; D009434:Neural Pathways / Q000187:drug effects* / Q000502:physiology; D015742:Propofol / Q000008:administration & dosage*; D014474:Unconsciousness
chemical_list: D018686:Anesthetics, Intravenous; D009294:Narcotics; D015742:Propofol
references: Arch Neurol. 2004 Feb;61(2):233-8
references: 14967772
references: Neuroimage. 2012 Jun;61(2):478-91
references: 22227888
references: Science. 2005 Dec 16;310(5755):1768-9; author reply 1768-9
references: 16357245
references: Ann Neurol. 1994 Jun;35(6):662-72
references: 8210222
references: Neuroimage. 1995 Mar;2(1):45-53
references: 9343589
references: Br Med J. 1974 Jun 22;2(5920):656-9
references: 4835444
references: Br J Anaesth. 2001 May;86(5):618-26
references: 11575335
references: Front Syst Neurosci. 2010 Dec 20;4:160
references: 21191476
references: J Neurosci. 1999 Jul 1;19(13):5506-13
references: 10377359
references: Front Syst Neurosci. 2010 Aug 26;4:
references: 20838471
references: Anesthesiology. 1995 Feb;82(2):393-403; discussion 27A
references: 7856898
references: J Neurosci. 2010 Jul 7;30(27):9095-102
references: 20610743
references: Can J Anaesth. 2011 Aug;58(8):714-24
references: 21630118
references: Brain. 2000 Aug;123 ( Pt 8):1589-601
references: 10908189
references: Trends Neurosci. 2003 Dec;26(12):671-5
references: 14624851
references: Schizophr Res. 2011 Apr;127(1-3):202-14
references: 21146961
references: PLoS One. 2011;6(8):e22790
references: 21829652
references: Conscious Cogn. 2009 Dec;18(4):1069-78
references: 19443244
references: N Engl J Med. 2010 Dec 30;363(27):2638-50
references: 21190458
references: Neuroimage. 2005 Jun;26(2):471-9
references: 15907304
references: Neuroimage. 2010 Jan 1;49(1):823-34
references: 19631277
references: PLoS One. 2012;7(1):e29072
references: 22242156
references: Anat Rec (Hoboken). 2010 Dec;293(12):1985-90
references: 21207521
references: Soc Neurosci. 2011;6(1):98-107
references: 20602286
references: Neuroimage. 2011 Feb 14;54(4):2695-705
references: 21047558
references: Science. 2006 Oct 6;314(5796):85-90
references: 17023650
references: Neuroimage. 2003 Aug;19(4):1273-302
references: 12948688
references: Neuroimage. 2012 Aug 1;62(1):464-81
references: 22579726
references: Anesthesiology. 2006 Mar;104(3):448-57
references: 16508391
references: Br J Anaesth. 2002 Jul;89(1):102-11
references: 12173223
references: PLoS Comput Biol. 2010 Mar 12;6(3):e1000709
references: 20300649
references: Science. 2008 Nov 7;322(5903):876-80
references: 18988836
references: Neuroimage. 2009 Jul 15;46(4):1004-17
references: 19306932
references: Neuroimage. 2011 Sep 15;58(2):339-61
references: 21477655
references: Hum Brain Mapp. 2008 Dec;29(12):1390-9
references: 17948882
references: Nat Rev Neurosci. 2008 May;9(5):370-86
references: 18425091
references: CNS Neurosci Ther. 2008 Summer;14(2):95-106
references: 18482023
references: Neuroimage. 2008 Jul 1;41(3):849-85
references: 18434205
references: Brain Connect. 2012;2(1):1-10
references: 22512333
references: Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):189-94
references: 16371474
references: Neuroimage. 2003 Dec;20(4):2135-41
references: 14683717
references: Anesthesiology. 2007 Jun;106(6):1128-33
references: 17525587
references: Neuroimage. 2011 Jul 1;57(1):198-205
references: 21524704
references: Cogn Neurodyn. 2010 Mar;4(1):37-59
references: 19768579
references: Brain Connect. 2012;2(6):291-302
references: 23153273
references: PLoS One. 2010 Oct 25;5(10):e13492
references: 21049093
references: Nature. 2010 Jun 10;465(7299):788-92
references: 20473285
references: Science. 2011 May 13;332(6031):858-62
references: 21566197
references: Anesthesiology. 2003 Sep;99(3):603-13
references: 12960544
references: Cereb Cortex. 2011 Jul;21(7):1519-31
references: 21109578
references: Anesthesiology. 2010 Nov;113(5):1038-53
references: 20885292
references: PLoS Comput Biol. 2007 Jun;3(6):e100
references: 17542641
references: Neuroimage. 2008 Jan 1;39(1):269-78
references: 17936017
references: Brain Connect. 2011;1(1):13-36
references: 22432952
references: Neuroimage. 2003 Jun;19(2 Pt 1):402-11
references: 12814589
references: Cereb Cortex. 2008 Jan;18(1):162-70
references: 17490991
references: Br J Anaesth. 1991 Jul;67(1):41-8
references: 1859758
references: Acta Anaesthesiol Scand. 2005 Jul;49(6):784-91
references: 15954960
references: Neuroimage. 2013 Jul 15;75:270-274
references: 22387473
references: J Pharmacol Exp Ther. 2001 Apr;297(1):338-51
references: 11259561
references: Physica D. 2009 Nov 1;238(21):2089-2118
references: 19862351
references: Neuroimage. 2004 Jul;22(3):1157-72
references: 15219588
references: Neuroimage. 2007 Nov 15;38(3):387-401
references: 17884583
references: PLoS One. 2010 Dec 02;5(12):e14224
references: 21151992
references: Hum Brain Mapp. 2008 Jul;29(7):839-47
references: 18219620
references: Mol Pharmacol. 2004 Jan;65(1):68-76
references: 14722238
references: Neuroimage. 2011 Sep 15;58(2):442-57
references: 21310247
references: Prog Brain Res. 2011;193:309-22
references: 21854971