title: Trial of labor compared to repeat cesarean section in women with no other risk factors than a prior cesarean delivery.
abstract: OBJECTIVE
  To compare outcomes with trial of labor after cesarean (TOLAC) or elective repeat cesarean delivery on maternal request (ERCD-MR).
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Danish university hospital.
  
  
  METHODS
  Women with TOLAC (n = 1161) and women with ERCD-MR (n = 622) between 2003 and 2010. Exclusion criteria were diabetes, two prior cesarean sections, index cesarean at a different hospital, a delivery after the index cesarean, twin gestation, gestational age <37(+0)  weeks and stillbirth.
  
  
  METHODS
  Data were obtained from the Aarhus Birth Cohort database, which comprised prospective registration of the deliveries.
  
  
  METHODS
  Adverse neonatal outcomes, risk factors for emergency cesarean, and uterine rupture in case of TOLAC.
  
  
  RESULTS
  TOLAC was associated with an increased risk of neonatal depression [odds ratio (OR) 3.6, 95% confidence interval (CI) 1.1-19.1] and neonatal intensive care unit admission (adjusted OR 1.9, 95% CI 1.3-2.8). Within the TOLAC group 67% delivered vaginally. In the TOLAC group 1.3% (n = 15) of the women had a complete uterine rupture. None of these infants had sequelae after 12 months. Significant risk factors for emergency cesarean were no prior vaginal delivery (adjusted OR 1.8, 95% CI 1.1-3.0), index emergency cesarean during labor (adjusted OR 3.0, 95% CI 2.3-4.1), maternal age ≥35 years (adjusted OR 1.9, 95% CI 1.3-2.8), pre-pregnancy body mass index ≥30 (adjusted OR 2.1, 95% CI 1.3-3.3), and birthweight 4000-4499 g (adjusted OR 1.5, 95% CI 1.1-2.1). Uterine rupture was associated with the use of epidural analgesia (OR 2.2, 95% CI 1.1-4.9) and no prior vaginal delivery (p = 0.03).
  
  
  CONCLUSIONS
  TOLAC is an acceptable individualized option for women without major risk factors.
authors: Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.
authors: Anne
authors: A
authors: Studsgaard
authors: Malene
authors: M
authors: Skorstengaard
authors: Julie
authors: J
authors: Glavind
authors: Lone
authors: L
authors: Hvidman
authors: Niels
authors: N
authors: Uldbjerg
mesh_terms: D000328:Adult; D017604:Cesarean Section, Repeat / Q000009:adverse effects* / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D016015:Logistic Models; D011247:Pregnancy; D012307:Risk Factors; D014219:Trial of Labor; D014597:Uterine Rupture / Q000209:etiology*; D016064:Vaginal Birth after Cesarean / Q000009:adverse effects* / Q000706:statistics & numerical data
keywords: Trial of labor after cesarean; adverse neonatal outcome; elective repeat cesarean delivery; mode of delivery; uterine rupture