title: Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy.
abstract: OBJECTIVE
  To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression.
  
  
  METHODS
  Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs.
  
  
  RESULTS
  Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls.
  
  
  CONCLUSIONS
  These results suggest an association between Cu/Zn SOD serum levels and clinical depression.
authors: Research Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555.
authors: A J
authors: AJ
authors: Russo
keywords: Cu/Zn SOD; depression; oxidative stress; super oxide dismutase
references: Mol Aspects Med. 2001 Aug-Oct;22(4-5):189-216
references: 11679166
references: Biochem Biophys Res Commun. 2003 Nov 28;311(4):1014-8
references: 14623283
references: Exp Physiol. 1997 Mar;82(2):291-5
references: 9129943
references: Psychosom Med. 2006 Jan-Feb;68(1):1-7
references: 16449405
references: Jpn J Cancer Res. 2001 Mar;92(3):367-76
references: 11267949
references: Biol Psychiatry. 2003 Aug 1;54(3):283-94
references: 12893104
references: Science. 1978 Sep 8;201(4359):875-80
references: 210504
references: Am J Med. 2000 Jul;109(1):33-44
references: 10936476
references: Carcinogenesis. 1988 Dec;9(12):2297-304
references: 2847879
references: J Behav Med. 1985 Dec;8(4):311-20
references: 2936891
references: Clin Biochem. 2005 Aug;38(8):700-5
references: 15963971
references: Diabetes Care. 1996 Oct;19(10):1097-102
references: 8886555
references: Psychosom Med. 2004 May-Jun;66(3):305-15
references: 15184688
references: Circulation. 2002 Aug 20;106(8):927-32
references: 12186795
references: Biol Psychiatry. 2003 Aug 1;54(3):269-82
references: 12893103
references: Biol Psychiatry. 2003 Aug 1;54(3):227-40
references: 12893099
references: Mutat Res. 2001 Jun 2;477(1-2):7-21
references: 11376682
references: Biol Trace Elem Res. 2003 Winter;96(1-3):209-15
references: 14716100
references: J Natl Cancer Inst. 1998 Dec 16;90(24):1888-93
references: 9862626
references: Proc Soc Exp Biol Med. 1999 Dec;222(3):246-52
references: 10601883
references: Am J Cardiol. 2005 Feb 1;95(3):317-21
references: 15670537
references: Am J Cardiol. 2002 Dec 15;90(12):1279-83
references: 12480034
references: Arch Gen Psychiatry. 1998 Jul;55(7):580-92
references: 9672048
references: Biol Psychiatry. 2003 Aug 1;54(3):317-29
references: 12893107
references: Int Arch Occup Environ Health. 2001 Mar;74(2):153-7
references: 11317710
references: Carcinogenesis. 2000 Mar;21(3):361-70
references: 10688856
references: Carcinogenesis. 1990 Sep;11(9):1447-50
references: 2205403
references: J Clin Invest. 1989 Nov;84(5):1644-9
references: 2553779
references: J Psychosom Res. 2002 Oct;53(4):903-6
references: 12377301
references: Annu Rev Biochem. 1982;51:21-59
references: 6287915
references: Stroke. 2001 Sep;32(9):1979-83
references: 11546884
references: Br J Nutr. 2002 May;87(5):393-403
references: 12010579
references: Mutat Res. 2001 Jun 27;493(1-2):23-30
references: 11516712
references: J Psychiatr Res. 2009 Jun;43(9):864-9
references: 19100996
references: Brain Behav Immun. 2003 Aug;17(4):276-85
references: 12831830
references: Trends Cardiovasc Med. 2003 Oct;13(7):270-5
references: 14522466
references: Cancer Res. 1994 Apr 1;54(7 Suppl):1918s-1923s
references: 8137312
references: Biol Psychiatry. 2002 Sep 15;52(6):559-88
references: 12361669
references: Coron Artery Dis. 2002 Aug;13(5):269-74
references: 12394651
references: J Psychosom Res. 2002 Oct;53(4):849-57
references: 12377293
references: Am J Clin Nutr. 2008 Sep;88(3):859S-62S
references: 18779309
references: JAMA. 2003 Jun 18;289(23):3095-105
references: 12813115
references: Psychol Bull. 1993 May;113(3):472-86
references: 8316610