title: Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.
abstract: Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.
authors: Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
authors: Deqi
authors: D
authors: Xu
authors: John O
authors: JO
authors: Cisar
authors: Frédéric
authors: F
authors: Poly
authors: Jinghua
authors: J
authors: Yang
authors: Jason
authors: J
authors: Albanese
authors: Madushini
authors: M
authors: Dharmasena
authors: Tint
authors: T
authors: Wai
authors: Patricia
authors: P
authors: Guerry
authors: Dennis J
authors: DJ
authors: Kopecko
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