title: Expression profiling of autophagy associated genes in placentas of preeclampsia.
abstract: Autophagy, a mechanism of cell survival during times of stress, may be active in normal placental maintenance, cushioning the fetus from strain during fluctuations in nutrient availability. Moreover, in cases of placental insufficiency, often present in preeclampsia, autophagy may be defective. We used published microarray datasets to analyze differential expression of autophagy pathway genes. No statistically significant difference in autophagy associated gene expression was found in preeclamptic vs. normal placenta samples. Thus although preeclampsia displays many of the features suggestive of altered autophagy, impaired placental autophagy as a cause of preeclampsia is not supported by whole placental tissue differential expression profiling.
authors: Department of Obstetrics and Gynecology, Hadassah University Medical Center, Mt Scopus, Jerusalem, Israel. Electronic address: dwohl@hadassah.org.il.
authors: D
authors: D
authors: Goldman-Wohl
authors: T
authors: T
authors: Cesla
authors: Y
authors: Y
authors: Smith
authors: C
authors: C
authors: Greenfield
authors: R
authors: R
authors: Dechend
authors: A C
authors: AC
authors: Staff
authors: M
authors: M
authors: Sugulle
authors: M S
authors: MS
authors: Weedon-Fekjær
authors: G M
authors: GM
authors: Johnsen
authors: S
authors: S
authors: Yagel
authors: R
authors: R
authors: Haimov-Kochman
mesh_terms: D001343:Autophagy / Q000235:genetics*; D030541:Databases, Genetic; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D040081:Protein Array Analysis
keywords: Autophagy; Differential expression profiling; Placenta; Preeclampsia