title: Polymorphisms in the promoter region of estrogen receptor β gene in endometrial cancer.
abstract: BACKGROUND
  The development of endometrial cancer is known to be affected by estrogens. Thus, genetic variations like single nucleotide polymorphisms (SNPs) in genes involved in estrogen biosynthesis, metabolism, and signal transduction might affect risk for endometrial cancer. In this study, we tested the hypothesis that polymorphisms in the promoter of ESR2 gene may be associated with susceptibility to this disease.
  
  
  METHODS
  We compared the frequency of three SNPs in the promoter region of ESR2 gene (rs2987983, rs3020450, and rs3020449) in 135 women with endometrial cancer and 135 healthy women serving as controls by means of allele-specific tetra-primer PCR.
  
  
  RESULTS
  Regarding allele frequency, allele positivity or genotype frequencies of these SNPs we did not observe any significant difference between healthy women and women with endometrial cancer.
  
  
  CONCLUSIONS
  Our data clearly suggest that the tested SNPs in the promotor region of human ESR2 gene are not associated with the development of endometrial cancer.
authors: Department of Obstetrics and Gynecology, University Medical Center Regensburg, 93053, Regensburg, Germany, clattrich@caritasstjosef.de.
authors: Claus
authors: C
authors: Lattrich
authors: Julia
authors: J
authors: Häring
authors: Susanne
authors: S
authors: Schüler
authors: Maciej
authors: M
authors: Skrzypczak
authors: Olaf
authors: O
authors: Ortmann
authors: Oliver
authors: O
authors: Treeck
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D017931:DNA Primers; D016889:Endometrial Neoplasms / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D017931:DNA Primers; D047629:Estrogen Receptor beta