title: Synthesis of 6-O-poly(ϵ-caprolactone)-L-ascorbic acid and its controlled release from supramolecular polymer micelles.
abstract: Lipophilic 6-O-poly (ϵ-caprolactone)-L-ascorbic acid (AA-6-PCL) is synthesized through ROP of ϵ-caprolactone (CL). The number of repeating CL units in the polymer chain varies from 6 to 19. AA-6-PCL loaded supramolecular polymer micelles (SMPMs) are constructed with β-cyclodextrin (β-CD) and PCL as blocks. Transmission electron microscopy images show a nanospheric morphology of the micelles with a size range of 43.3 ± 5.0 nm. The drug loading contents are 22.53-39.23% for AA-6-PCL. AA-6-PCL exhibits high radical scavenging capacity (93.96-96.73%) and efficient scavenging potency, and a cytotoxicity study proves the excellent cytocompatibility of AA-6-PCL loaded β-CD/PCL SMPMs, which altogether herald their potential application in the study of the induced pluripotent stem cells.
authors: Department of Polymer Science, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
authors: Feifei
authors: F
authors: Li
authors: Bin
authors: B
authors: Chen
authors: Zhaohua
authors: Z
authors: Ping
authors: Xiangxiang
authors: X
authors: Jia
authors: Xin
authors: X
authors: Guo
authors: Longqiang
authors: L
authors: Xiao
authors: Lijian
authors: L
authors: Liu
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D047392:beta-Cyclodextrins / Q000008:administration & dosage
chemical_list: D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; D011108:Polymers; D047392:beta-Cyclodextrins; C016240:polycaprolactone; C031215:betadex; D001205:Ascorbic Acid
keywords: L-ascorbic acid; controlled release; induced pluripotent stem cells; ring-opening polymerization; supramolecular polymer micelles