title: Clinicopathological and molecular markers associated with prognosis and treatment effectiveness of endometrial stromal sarcoma: a retrospective study in China.
abstract: OBJECTIVE
  To evaluate the clinicopathological and immunophenotypic characteristics of endometrial stromal sarcoma (ESS) in China.
  
  
  METHODS
  Seventy-two consecutive ESS cases treated between 1995 and 2009 were retrospectively reviewed.
  
  
  RESULTS
  Sixty-three patients received surgical treatment. Forty-one patients underwent pelvic lymphadenectomy. In paraffin-embedded specimens, expression of the following molecular markers was detected: CD10 (27/36), vimentin (37/38), HHF35 (3/32), S-100 (0/25), desmin (2/29), CD117 (0/23), CD34 (2/24), alpha-inhibin (0/17), CK (1/34), CD99 (4/9), smooth muscle actin (5/25), EMA (0/7), estrogen receptor (13/16) and progesterone receptor (13/16). CD10 and vimentin were expressed more frequently in these specimens. Tumor classification, CD10 and surgical procedures were significantly associated with disease-free survival (DFS). Surgical procedures were significantly associated with overall survival (OS). Tumor stage (P = 0.024) and surgical procedure (P = 0.042) were found to be significant independent prognostic factors for DFS. No complete or partial response was observed among patients who received radiotherapy or chemotherapy.
  
  
  CONCLUSIONS
  Our results indicate that total hysterectomy with bilateral salpingo-oophorectomy followed by pelvic lymphadenectomy is associated with an improved treatment outcome. CD10-negative expression may contribute to the malignant characteristics and recurrence associated with ESS.
authors: Li
authors: L
authors: He
authors: Jun-Dong
authors: JD
authors: Li
authors: Ying
authors: Y
authors: Xiong
authors: Xin
authors: X
authors: Huang
authors: Long
authors: L
authors: Huang
authors: Jia-xin
authors: JX
authors: Lin
authors: Yun
authors: Y
authors: Zhou
authors: Min
authors: M
authors: Zheng
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002681:China; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D016130:Immunophenotyping; D008197:Lymph Node Excision; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies; D018203:Sarcoma, Endometrial Stromal / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
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