title: Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.
abstract: OBJECTIVE
  Myocardial infarction (MI) is a cause of high morbidity and mortality in the world. Sodium tanshinone IIA sulphonate (STS) has been well used in Oriental medicine for treating cardiovascular diseases, however, the underlying mechanisms remain unclear. Alterations of circulating lipid profiles, increased fatty acid β-oxidation and oxidative stress play most important roles in the pathogenesis of MI. The present study aims to elucidate whether STS possesses cardioprotective effect against MI driven by isoproterenol (ISO), and to investigate its potential mechanisms of action.
  
  
  METHODS
  MI was induced by subcutaneous injection of ISO (85 mg/kg at interval of 24 h for 2 consecutive days) to rats. The rats were randomly divided into 6 groups: (1) control; (2) ISO; (3) STS (16 mg/kg) +control; (4-6) STS (16, 8, 4 mg/kg) +ISO.
  
  
  RESULTS
  Our study showed that STS could ameliorate cardiac dysfunction and variation of myocardial zymogram, up-regulate antioxidant systems, and maintain the levels of circulating lipids driven by supramaximal doses ISO as well. Moreover, modulation of redox-sensitive extracellular signal-regulated kinase1/2 (ERK1/2)/Nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and AMP-activated protein kinase (AMPK)/acetyl CoA carboxylase (ACC)/carnitine palmitoyltransferase (CPT) 1 pathways were involved in STS induced cardioprotection.
  
  
  CONCLUSIONS
  STS exerts strong favorable cardioprotective action. Additionally, the properties of STS, such as anti-dyslipidemia, anti-oxidant and inhibition of fatty acid β-oxidation, may be the mechanisms underlying the observed results.
authors: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu Province, PR China.
authors: Bo
authors: B
authors: Wei
authors: Mei-Gui
authors: MG
authors: You
authors: Jing-Jing
authors: JJ
authors: Ling
authors: Lin-Lin
authors: LL
authors: Wei
authors: Kai
authors: K
authors: Wang
authors: Wen-Wen
authors: WW
authors: Li
authors: Tong
authors: T
authors: Chen
authors: Qian-Ming
authors: QM
authors: Du
authors: Hui
authors: H
authors: Ji
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000378:metabolism*; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000097:blood* / Q000737:chemistry; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology; D006439:Hemodynamics; D007545:Isoproterenol / Q000737:chemistry; D008055:Lipids / Q000097:blood* / Q000737:chemistry; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010616:Phenanthrenes / Q000627:therapeutic use*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D005227:Fatty Acids; D008055:Lipids; D010616:Phenanthrenes; D010936:Plant Extracts; C024894:tanshinone II A sodium sulfonate; D007545:Isoproterenol; D010100:Oxygen
keywords: Dyslipidemia; Fatty acid β-oxidation; Isoproterenol; Myocardial infarction; Oxidative stress; Sodium tanshinone IIA sulphonate