title: Epigenetic developmental programs and adipogenesis: implications for psychotropic induced obesity.
abstract: Psychotropic agents are notorious for their ability to increase fat mass in psychiatric patients. The two determinants of fat mass are the production of newly differentiated adipocytes (adipogenesis), and the volume of lipid accumulation. Epigenetic programs have a prominent role in cell fate commitments and differentiation required for adipogenesis. In parallel, epigenetic effects on energy metabolism are well supported by several genetic models. Consequently, a variety of psychotropics, often prescribed in combinations and for long periods, may utilize a common epigenetic effector path causing an increase in adipogenesis or reduction in energy metabolism. In particular, the recent discovery that G protein coupled signaling cascades can directly modify epigenetic regulatory enzymes implicates surface receptor activity by psychotropic medications. The potential therapeutic implications are also suggested by the effects of the clinically approved antidepressant tranylcypromine, also a histone demethylase inhibitor, which has impressive therapeutic effects on metabolism in the obese phenotype.
authors: The Psychiatric Institute; University of Illinois at Chicago; Chicago, IL USA.
authors: Kayla
authors: K
authors: Chase
authors: The Psychiatric Institute; University of Illinois at Chicago; Chicago, IL USA; Jesse Brown Veterans Affairs Medical Center; Chicago, IL USA.
authors: Rajiv P
authors: RP
authors: Sharma
mesh_terms: D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics; D008745:Methylation; D009765:Obesity / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D011619:Psychotropic Drugs / Q000009:adverse effects*; D014191:Tranylcypromine / Q000494:pharmacology; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D011619:Psychotropic Drugs; D014191:Tranylcypromine
keywords: epigenetics; histone methylation; obesity; psychotropics; schizophrenia