title: Chronic psychosocial stress causes delayed extinction and exacerbates reinstatement of ethanol-induced conditioned place preference in mice.
abstract: BACKGROUND
  We have shown previously, using an animal model of voluntary ethanol intake and ethanol-conditioned place preference (EtOH-CPP), that exposure to chronic psychosocial stress induces increased ethanol intake and EtOH-CPP acquisition in mice.
  
  
  OBJECTIVE
  Here, we examined the impact of chronic subordinate colony (CSC) exposure on EtOH-CPP extinction, as well as ethanol-induced reinstatement of CPP.
  
  
  METHODS
  Mice were conditioned with saline or 1.5 g/kg ethanol and were tested in the EtOH-CPP model. In the first experiment, the mice were subjected to 19 days of chronic stress, and EtOH-CPP extinction was assessed during seven daily trials without ethanol injection. In the second experiment and after the EtOH-CPP test, the mice were subjected to 7 days of extinction trials before the 19 days of chronic stress. Drug-induced EtOH-CPP reinstatement was induced by a priming injection of 0.5 g/kg ethanol.
  
  
  RESULTS
  Compared to the single-housed colony mice, CSC mice exhibited increased anxiety-like behavior in the elevated plus maze (EPM) and the open field tests. Interestingly, the CSC mice showed delayed EtOH-CPP extinction. More importantly, CSC mice showed increased alcohol-induced reinstatement of the EtOH-CPP behavior.
  
  
  CONCLUSIONS
  Taken together, this study indicates that chronic psychosocial stress can have long-term effects on EtOH-CPP extinction as well as drug-induced reinstatement behavior and may provide a suitable model to study the latent effects of chronic psychosocial stress on extinction and relapse to drug abuse.
authors: Department of Anatomy, Tawam Medical Campus, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, UAE, amine.bahi@uaeu.ac.ae.
authors: Amine
authors: A
authors: Bahi
authors: Jean-Luc
authors: JL
authors: Dreyer
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000150:complications / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D004291:Dominance-Subordination; D000431:Ethanol / Q000494:pharmacology*; D005108:Extinction, Psychological; D006799:Housing, Animal; D008297:Male; D051379:Mice; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*
chemical_list: D000431:Ethanol
references: J Psychopharmacol. 2012 Feb;26(2):315-23
references: 22182742
references: Behav Med. 1997 Fall;23(3):101-11
references: 9397282
references: Addict Biol. 2013 Jan;18(1):66-77
references: 23126471
references: Eur J Neurosci. 2003 Apr;17(7):1465-72
references: 12713649
references: Science. 1973 Jun 29;180(4093):1383-4
references: 4736265
references: Neuropsychopharmacology. 2004 Jun;29(6):1156-65
references: 15100697
references: Eur J Pharmacol. 2001 Mar;415(2-3):203-8
references: 11275000
references: Eur Neuropsychopharmacol. 2012 Sep;22(9):672-82
references: 22377193
references: Hum Psychopharmacol. 2010 Jul;25(5):368-76
references: 20589926
references: Peptides. 2013 May;43:48-55
references: 23428971
references: Psychopharmacology (Berl). 2006 May;185(4):459-70
references: 16555060
references: Ann N Y Acad Sci. 2008 Dec;1148:184-95
references: 19120108
references: Neuropsychopharmacology. 2004 Jul;29(7):1312-20
references: 15039768
references: Neuroscience. 2003;119(2):497-505
references: 12770563
references: Psychopharmacology (Berl). 2003 Jul;168(1-2):66-74
references: 12442201
references: Curr Psychiatry Rep. 2007 Oct;9(5):388-95
references: 17915078
references: Alcohol Clin Exp Res. 2011 Oct;35(10):1794-803
references: 21762177
references: Arch Gen Psychiatry. 1986 Aug;43(8):733-8
references: 3729667
references: Pharmacol Biochem Behav. 2012 Apr;101(2):193-200
references: 22269296
references: Psychopharmacology (Berl). 2007 Dec;195(3):345-55
references: 17705061
references: Stress. 2013 Jul;16(4):461-8
references: 23566157
references: Alcohol Clin Exp Res. 2005 Feb;29(2):185-95
references: 15714042
references: J Neuroimmunol. 2001 Mar 1;114(1-2):122-30
references: 11240023
references: Brain Res. 1993 May 21;611(2):352-6
references: 8334527
references: Psychoneuroendocrinology. 2012 Oct;37(10):1676-87
references: 22444976
references: Curr Pharm Des. 2013;19(40):7009-25
references: 23574439
references: Psychopharmacology (Berl). 2012 Jul;222(1):141-53
references: 22222864
references: Psychopharmacology (Berl). 2011 Mar;214(1):17-31
references: 20596857
references: J Clin Endocrinol Metab. 1993 Aug;77(2):518-22
references: 8393888
references: Neuroscience. 2006;138(1):235-43
references: 16359808
references: PLoS One. 2012;7(12):e52371
references: 23300653
references: Behav Brain Res. 2011 Oct 31;224(2):350-7
references: 21718722
references: Psychopharmacology (Berl). 2005 Dec;183(3):341-9
references: 16254734
references: Eur J Pharmacol. 2000 Aug 11;401(3):365-73
references: 10936495
references: Neuropsychopharmacology. 2007 Nov;32(11):2310-20
references: 17342167
references: Psychopharmacology (Berl). 2004 Sep;175(2):154-62
references: 14985920
references: Pharmacology. 1978;16(5):259-67
references: 25444
references: Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):653-71
references: 2851859
references: Psychopharmacology (Berl). 2003 Jul;168(1-2):184-191
references: 12447607
references: Neuroscience. 1998 Jan;82(1):147-59
references: 9483511
references: J Psychosom Res. 2002 Oct;53(4):865-71
references: 12377295
references: CNS Neurol Disord Drug Targets. 2010 Mar;9(1):77-86
references: 20201818
references: Endocrinology. 2007 Feb;148(2):670-82
references: 17110427
references: Pharmacol Ther. 2006 Sep;111(3):855-76
references: 16545872
references: Biol Psychiatry. 2009 Dec 15;66(12):1139-46
references: 19716552
references: Neuropsychopharmacology. 2008 Jan;33(2):226-36
references: 17443128
references: Behav Brain Res. 2012 Jan 1;226(1):250-8
references: 21945298
references: Psychopharmacology (Berl). 2001 Dec;158(4):343-59
references: 11797055
references: Behav Brain Res. 2011 Jun 20;220(1):100-5
references: 21277332
references: Neuropharmacology. 2013 Apr;67:359-69
references: 23220295
references: Pharmacol Ther. 2011 Feb;129(2):149-71
references: 20951730
references: Behav Brain Res. 2002 Nov 15;136(2):389-97
references: 12429400
references: Psychopharmacology (Berl). 2000 Oct;152(2):140-8
references: 11057517
references: Synapse. 2009 Feb;63(2):87-94
references: 19016239
references: Neuroreport. 2000 Jun 26;11(9):1939-43
references: 10884047
references: J Clin Endocrinol Metab. 1991 Jun;72(6):1290-5
references: 2026749
references: Psychoneuroendocrinology. 2005 Oct;30(9):880-91
references: 15975729
references: Stress. 2013 Jul;16(4):441-51
references: 23194312
references: Alcohol. 1991 Sep-Oct;8(5):401-4
references: 1665698
references: Brain Res. 1992 Dec 11;598(1-2):343-8
references: 1486498
references: Physiol Behav. 2008 Mar 18;93(4-5):733-41
references: 18155096
references: Psychopharmacology (Berl). 2013 Jul;228(1):85-95
references: 23474889
references: Biol Psychiatry. 2004 Apr 1;55(7):715-23
references: 15039000
references: Stress. 2009 Jan;12(1):58-69
references: 19116889
references: Neuroreport. 1999 Sep 29;10(14):3015-9
references: 10549815
references: Brain Res. 1996 May 20;721(1-2):140-9
references: 8793094
references: Brain Res. 1994 Mar 21;640(1-2):136-9
references: 8004442
references: Int J Aging Hum Dev. 1992;35(2):99-123
references: 1399077
references: Br J Addict. 1987 Apr;82(4):381-92
references: 3555574
references: Psychopharmacology (Berl). 2009 Dec;207(3):485-98
references: 19798482
references: Pharmacol Biochem Behav. 2013 Apr;105:83-8
references: 23402940
references: Endocrinology. 2008 Jun;149(6):2727-36
references: 18308845
references: Psychopharmacology (Berl). 1996 Jun;125(4):385-91
references: 8826544
references: Pol J Pharmacol. 1993 May-Jun;45(3):243-52
references: 8220658