title: Skin discolouration with acute onset parkinsonism secondary to systemic zirconium intoxication.
abstract: A 72-year-old woman presented with suspected parkinsonism and discolouration of the skin especially on sun-exposed areas. Thorough investigation revealed systemic zirconium intoxication due to intake of metallic colloids as a home remedy as a cause of the skin colour change. There may be an association between skin discolouration and her parkinsonism. This is unique in that various clinical manifestations developed following systemic ingestion of zirconium and this should serve as a warning on the risk of taking illicit dietary supplements.
authors: Department of Dermatology, Korea University College of Medicine, Republic of Korea.
authors: Hwa J
authors: HJ
authors: Ryu
authors: Su J
authors: SJ
authors: Yoon
authors: Jong-Tae
authors: JT
authors: Park
authors: Young H
authors: YH
authors: Kim
authors: Jin M
authors: JM
authors: Jung
authors: Moon-Ho
authors: MH
authors: Park
authors: Im J
authors: IJ
authors: Rhyu
authors: Do-Young
authors: DY
authors: Kwon
mesh_terms: D000368:Aged; D019587:Dietary Supplements / Q000633:toxicity; D005260:Female; D006801:Humans; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D012880:Skin Pigmentation / Q000187:drug effects*; D014466:Ultraviolet Rays / Q000009:adverse effects; D015040:Zirconium / Q000633:toxicity*
chemical_list: D015040:Zirconium
keywords: Toxicology; clinical studies; intoxication; parkinsonism; skin discolouration; zirconium