title: Silver and gold nanostructures: antifungal property of different shapes of these nanostructures on Candida species.
abstract: The shape of nanoparticles is an important determinant of their physical and chemical properties, possibly including the little-explored area of their use as antifungal agents. Therefore, we evaluated the in vitro antifungal activities of three different shapes of silver and gold nanostructures, including nanocubes, nanospheres, and nanowires, on Candida albicans, C. glabrata and C. tropicalis, using the microdilution and disk diffusion methods as per the guidelines of the Clinical and Laboratory Standards Institute. We found that silver and gold nanocubes had higher antifungal properties against the test species than nanospheres and nanowires. While some isolates were resistant to silver and gold nanospheres and nanowires, none of the isolates were resistant to silver and gold nanocubes. The occurrence of resistance is a new finding which should be further explored.
authors: Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Ali
authors: A
authors: Jebali
authors: Farzaneh Haji Esmaeil
authors: FH
authors: Hajjar
authors: Fereydoun
authors: F
authors: Pourdanesh
authors: Seyedhossein
authors: S
authors: Hekmatimoghaddam
authors: Bahram
authors: B
authors: Kazemi
authors: Alireza
authors: A
authors: Masoudi
authors: Karim
authors: K
authors: Daliri
authors: Najme
authors: N
authors: Sedighi
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D041022:Candida tropicalis / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D005260:Female; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D049329:Nanostructures; D012834:Silver / Q000494:pharmacology*; D014621:Vagina / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D012834:Silver; D006046:Gold
keywords: Candida species; Silver nanostructures; antifungal property; gold nanostructures