title: Interleukin-6 -174G/C gene polymorphism affects muscle damage response to acute eccentric resistance exercise in elderly obese women.
abstract: The IL-6 gene polymorphism has been associated with disease prevalence and different physiological responses to exercise. Eccentric resistance exercise (ERE) is considered a nonpharmacological tool to prevent the chronic degenerative profile associated with aging and obesity. Consequently, the aim of the present study was to investigate the influence of IL-6 -174G/C polymorphism on acute interleukin-6 (IL-6) and creatine kinase (CK) temporal response to ERE in elderly obese women. Ninety women completed seven sets of ten repetitions (eccentric only) of an acute ERE session at 110% of the ten repetitions maximum (10RM). IL-6 genotypes displayed no difference at baseline. ERE induced changes in CK concentration over time occurred only in the GG group, F(2.619, 136.173)=5.199, p=0.003, with CK activity increased from 106.8±6.9 U/l pre-intervention to 122.7±11.2 U/l at 24 h and 131.9±14.4 U/l at 48 h post-exercise. IL-6 concentration in the GG group was lower than the CC/CG group only at 0 h post-exercise (3.78±0.58 pg/ml versus 6.51±1.91 pg/ml, p=0.030). Only the GG genotype group had higher CK activity 24-48 h following ERE and greater CK integral values, while IL-6 activity over 48 h was higher in the CC/CG genotype group. In conclusion, IL-6 genotype affects CK and IL-6 in response to ERE. It is of interest that the ERE protocol induced an elevation in CK, indicating possible muscle damage without exacerbating IL-6 and CK for the GG genotype.
authors: University of Brasilia, Graduation Program in Health Sciences, Brasilia, Brazil. Electronic address: silvana.funghetto@gmail.com.
authors: Silvana Schwerz
authors: SS
authors: Funghetto
authors: Jonato
authors: J
authors: Prestes
authors: Alessandro de Oliveira
authors: Ade O
authors: Silva
authors: Darlan L
authors: DL
authors: Farias
authors: Tatiane G
authors: TG
authors: Teixeira
authors: Denis Cesar Leite
authors: DC
authors: Vieira
authors: Vinícius C
authors: VC
authors: Souza
authors: Nuno M F
authors: NM
authors: Sousa
authors: James W
authors: JW
authors: Navalta
authors: Gislane F
authors: GF
authors: Melo
authors: Margô Gomes de Oliveira
authors: MG
authors: Karnikowski
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D053580:Muscle Strength / Q000235:genetics / Q000276:immunology / Q000502:physiology; D018482:Muscle, Skeletal / Q000276:immunology / Q000293:injuries* / Q000503:physiopathology*; D009765:Obesity / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D020641:Polymorphism, Single Nucleotide; D055070:Resistance Training
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D003402:Creatine Kinase
keywords: Aging; Creatine kinase; Eccentric resistance training; Genetics; Interleukin-6