title: The adipokine/ceramide axis: key aspects of insulin sensitization.
abstract: Until recently, sphingolipid physiology was primarily the domain of oncologists and immunologists. However, mounting evidence implicates ceramides and their derivatives in various aspects of metabolism via directly impacting the insulin receptor as well as modulating cell survival and proliferation. More recent observations suggest a strong link between a number of adipokines and ceramide catabolism. Here, we aim to briefly review the available data on the established metabolic effects of sphingolipids in various cell types and will discuss how adipokines exert a critical influence on the steady state levels of these lipid mediators.
authors: Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549.
authors: Jonathan Y
authors: JY
authors: Xia
authors: Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549.
authors: Thomas S
authors: TS
authors: Morley
authors: Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549.|Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549.
authors: Philipp E
authors: PE
authors: Scherer
mesh_terms: D054392:Adipokines / Q000502:physiology*; D000818:Animals; D002518:Ceramides / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008246:Lysophospholipids / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism; D009928:Organ Specificity; D013107:Sphingolipids / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D054392:Adipokines; D002518:Ceramides; D008246:Lysophospholipids; D013107:Sphingolipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: Ceramide target tissues; Ceramides; Insulin sensitivity; Plasma ceramide levels; Sphingolipids
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