title: (-)-Arctigenin as a lead compound for anticancer agent.
abstract: (-)-Arctigenin, an important active constituent of the traditional Chinese herb Fructus Arctii, was found to exhibit various bioactivities, so it can be used as a good lead compound for further structure modification in order to find a safer and more potent medicine. (-)-Arctigenin derivatives 1-5 of (-)-arctingen were obtained by modifying with ammonolysis at the lactone ring and sulphonylation at C (6') and C (6″) and O-demethylation at CH3O-C (3'), CH3O-C (3″) and CH3O-C (4″), and their anticancer bioactivities were examined.
authors: a College of Pharmacy, Liaoning University of Traditional Chinese Medicine , 77 Life One Road, DD Port, Dalian , 116600 , P.R. China.
authors: Gui-Rong
authors: GR
authors: Chen
authors: Hong-Fu
authors: HF
authors: Li
authors: De-Qiang
authors: DQ
authors: Dou
authors: Yu-Bin
authors: YB
authors: Xu
authors: Hong-Shuai
authors: HS
authors: Jiang
authors: Fu-Rui
authors: FR
authors: Li
authors: Ting-Guo
authors: TG
authors: Kang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055808:Drug Discovery; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D017705:Lignans; C071942:arctigenin