title: Accuracy of transcutaneous bilirubin measurement in preterm low-birth-weight neonates.
abstract: The objective of this study was to evaluate the correlation and agreement between transcutaneous and serum bilirubin among preterm low-birth-weight neonates. Neonates born at <35 weeks of gestation with birth weight <2,000 g were enrolled prospectively. Transcutaneous bilirubin (TcB) was measured at forehead, sternum, and abdomen at 24 ± 6 and 72 ± 12 h after birth and when icterus involved arms or legs (Kramer zone 4-5). Serum total bilirubin (STB) was measured by microbilimeter (STB-M) at all these time-points and by high-performance liquid chromatography (STB-H) at one randomly chosen time-point. A total of 1,619 observations were made in 256 neonates (median gestation, 34 weeks (IQR, 32-35), birth weight 1,522 ± 288 g). Overall there was excellent correlation and agreement between TcB and STB-M with TcB on forehead being most accurate (r = 0.84, mean difference, 0.3 ± 1.9 mg/dL) followed by TcB on abdomen (r = 0.73, mean difference, 1.5 ± 2.6 mg/dL) and sternum (r = 0.72, mean difference, 1.5 ± 2.6 mg/dL). TcB performed well at all three points of measurement with best correlations being observed at icterus level 4/5. Correlation between TcB and STB-H measured by high-performance liquid chromatography was less strong but significant (r = 0.59 to 0.69 at different time points of measurement).
  
  
  CONCLUSIONS
  TcB has good correlation and agreement with STB in preterm low-birth-weight neonates born at ≥28 weeks of gestation.
authors: Department of Pediatrics, Government Medical College Hospital, Chandigarh, 160 030, India, drdeepakchawla@hotmail.com.
authors: Deepak
authors: D
authors: Chawla
authors: Suksham
authors: S
authors: Jain
authors: Gurjit
authors: G
authors: Kaur
authors: Vikas
authors: V
authors: Sinhmar
authors: Vishal
authors: V
authors: Guglani
mesh_terms: D001663:Bilirubin / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004867:Equipment Design; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000175:diagnosis*; D007194:India; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000175:diagnosis*; D019102:Infant, Very Low Birth Weight; D008297:Male; D015997:Neonatal Screening / Q000295:instrumentation*; D011237:Predictive Value of Tests; D013053:Spectrophotometry / Q000295:instrumentation*; D013223:Statistics as Topic; D062606:Tertiary Care Centers
chemical_list: D001663:Bilirubin
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