title: Total synthesis of zyzzyanones A-D.
abstract: Zyzzyanones A-D is a group of biologically active marine alkaloids isolated from Australian marine spongeZyzzya fuliginosa. They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4,7-quinone derivative and involves 6-7 steps. The key step in the synthesis involves the construction of a pyrrole ring in one step using a Mn(OAc)3mediated oxidative free radical cyclization reaction of a 6-benzylamino indole-4,7-quinone derivative with 4-benzyloxyphenyl acetaldehyde diethyl acetal in CH3CN.
authors: Department of Chemistry, University of Alabama at Birmingham, 901 14 Street South, Birmingham, Alabama 35294, USA.
authors: Dwayaja H
authors: DH
authors: Nadkarni
authors: Srinivasan
authors: S
authors: Murugesan
authors: Sadanandan E
authors: SE
authors: Velu
keywords: Alkaloid; Marine; Mn(OAc)3; Quinone; Zyzzyanone
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