title: Stereotactic radiofrequency amygdalohippocampectomy: two years of good neuropsychological outcomes.
abstract: OBJECTIVE
  To provide two-year seizure and neuropsychological outcomes in patients treated by stereotactic radiofrequency amygdalohippocampectomy (SAHE), an alternative, minimally invasive method for the treatment of mesial temporal lobe epilepsy (MTLE).
  
  
  METHODS
  Thirty-seven MTLE patients treated by SAHE (26 left-sided, 11 right-sided) were included. Patients underwent neuropsychological evaluation by the Wechsler Adult Intelligence Scale-Revised and the Wechsler Memory Scale-Revised preoperatively, 1 year and 2 years after SAHE.
  
  
  RESULTS
  Two years after SAHE twenty-eight (75.5%) patients were assessed as Engel Class I and seven (18.9%) patients as Engel Class II. In two patients (5.4%) treatment failed, one of them was classified as Class III and one as Class IV. Irrespective of the laterality of the procedure, the group improved significantly in Global and Verbal Memory Quotients, Attention, Delayed Recall, Semantic Long-term memory subtest and Working Memory. Additionally, increases in Full-scale, Verbal and Visual Intelligence Quotients were detected on the group level.
  
  
  CONCLUSIONS
  In the present study we report good seizure control and neuropsychological outcomes after SAHE in our patients. We hypothesize that good neuropsychological results were achieved by the incomplete destruction of target structures, sparing the lateral temporal neocortex, and also partially by practice effect. Treatment failures in seizure control may be attributed to larger epileptogenic zones.
authors: Epilepsy Center Na Homolce Hospital, Department of Radiology, Roentgenova 2, 150 00 Prague 5, Czech Republic. Electronic address: hana.malikova@homolka.cz.
authors: Hana
authors: H
authors: Malikova
authors: Lenka
authors: L
authors: Kramska
authors: Zdenek
authors: Z
authors: Vojtech
authors: Jiri
authors: J
authors: Lukavsky
authors: Roman
authors: R
authors: Liscak
mesh_terms: D000328:Adult; D000679:Amygdala / Q000601:surgery*; D001288:Attention / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000523:psychology* / Q000601:surgery*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006624:Hippocampus / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016634:Radiosurgery / Q000379:methods*; D012640:Seizures / Q000601:surgery; D016896:Treatment Outcome; D014705:Verbal Behavior; D014888:Wechsler Scales; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Epilepsy surgery; Neuropsychology outcome; Stereotactic surgery; Temporal lobe epilepsy