title: Apelin could reduce risk of contrast-induced nephropathy in patients with congestive heart failure.
abstract: Compared to the normal population, patients with congestive heart failure are at higher risk for contrast-induced nephropathy. A variety of interventions are suggested to reduce the risk for contrast-induced nephropathy. Unfortunately results of none of current protective treatments are satisfactory. Apelin a vasodilator adipocytokine, positively inotropic agent, and free radical scavenger has been recently introduced. It has been shown that endogenous apelin levels are decreased in patients with congestive heart failure. Two major mechanisms have been suggested for pathophysiology of contrast induced nephropathy including reactive oxygen species production and impaired renal perfusion due to vasoconstriction. Pretreatment with recombinant apelin (exogenous apelin-13), could compensate decreased endogenous apelin serum levels of congestive heart failure patients. Its antioxidant and cell-protective properties, decrease nephrotoxicity of contrast agent; additionally impaired renal perfusion due to malfunction of cardiac pump will refurbish, because of positively inotropic property of apelin plus its vasodilatation effect in renal arteries. We believe that the triangle of increased contractility, decreased vascular resistance and decreased contrast agent nephrotoxicity could significantly reduce risk of contrast-induced nephropathy in patients with congestive heart failure.
authors: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Soroush
authors: S
authors: Seifirad
authors: Farzad
authors: F
authors: Masoudkabir
mesh_terms: D000073861:Apelin; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D008954:Models, Biological; D017382:Reactive Oxygen Species / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D003287:Contrast Media; D036341:Intercellular Signaling Peptides and Proteins; D017382:Reactive Oxygen Species; D011994:Recombinant Proteins