title: [Imaging and quantification of corneal neovascularization].
abstract: Corneal neovascularization is defined as the invasion of vessels into the normally avascular clear corneal stroma, secondary to acute or chronic tissue injury. In addition to decreasing visual acuity, vascularity introduces circulating immune cells, reducing corneal immune privilege and the graft survival of subsequent keratoplasty. Thus, reducing neovascularization has become a recent therapeutic target in order to increase the success of corneal transplantation. Comparing the effects of antiangiogenic drugs assumes that we are able to quantify corneal neovascularization before and after treatment. In the first part of this literature review, we present the various methods to document neovessels (color photos, fluorescein and indocyanine green anterior segment angiography, in vivo confocal microscopy). Next, we report methods to classify and quantify corneal neovascularization.
authors: Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex 1, France; Service d'ophtalmologie, clinique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France. Electronic address: yohanbenayoun@hotmail.fr.
authors: Y
authors: Y
authors: Benayoun
authors: R
authors: R
authors: Rosenberg
authors: G
authors: G
authors: Casse
authors: B
authors: B
authors: Dallaudière
authors: P-Y
authors: PY
authors: Robert
mesh_terms: D016510:Corneal Neovascularization / Q000175:diagnosis* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D018613:Microscopy, Confocal; D010781:Photography
chemical_list: D007208:Indocyanine Green
keywords: Angiogenesis; Angiogenèse; Corneal neovascularization; Corneal transplants; Greffes de cornées; Néovascularisation cornéenne