title: Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer.
abstract: Bisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcification and metaplastic bone formation. The patient's history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. We stopped the treatment since we believed that the cutaneous dystrophic calcification could be associated with her long term bisphosphonate therapy. Adverse cutaneous events with bisphosphonates are very rare, and dystrophic calcification has not been reported previously. The dystrophic calcification and metaplastic bone formation in this patient are thought to be due to long term bisphosphonate usage.
authors: Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey.
authors: Ali Murat
authors: AM
authors: Tatlı
authors: Seyda
authors: S
authors: Gunduz
authors: Sema Sezgin
authors: SS
authors: Göksu
authors: Deniz
authors: D
authors: Arslan
authors: Mukremin
authors: M
authors: Uysal
authors: Cumhur İbrahim
authors: Cİ
authors: Başsorgun
authors: Hasan Şenol
authors: HŞ
authors: Coşkun
references: Skinmed. 2011 Jul-Aug;9(4):258-9
references: 21980713
references: Br J Dermatol. 2005 May;152(5):1022-5
references: 15888163
references: J Am Acad Dermatol. 2011 Jul;65(1):1-12; quiz 13-4
references: 21679810
references: Med Oncol. 2008;25(3):356-9
references: 18196480
references: Ann Oncol. 2012 May;23(5):1341-1347
references: 21986094
references: Cancer Treat Rev. 2001 Jun;27(3):165-76
references: 11417967
references: Expert Opin Drug Saf. 2007 May;6(3):305-13
references: 17480179
references: Dermatol Surg. 2009 Mar;35(3):457-61
references: 19243405
references: Int Wound J. 2005 Jun;2(2):142-7
references: 16722863
references: BMC Cancer. 2006 Jul 06;6:179
references: 16824210