title: Probabilistic brains: knowns and unknowns.
abstract: There is strong behavioral and physiological evidence that the brain both represents probability distributions and performs probabilistic inference. Computational neuroscientists have started to shed light on how these probabilistic representations and computations might be implemented in neural circuits. One particularly appealing aspect of these theories is their generality: they can be used to model a wide range of tasks, from sensory processing to high-level cognition. To date, however, these theories have only been applied to very simple tasks. Here we discuss the challenges that will emerge as researchers start focusing their efforts on real-life computations, with a focus on probabilistic learning, structural learning and approximate inference.
authors: Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York, USA. alexandre.pouget@unige.ch
authors: Alexandre
authors: A
authors: Pouget
authors: Jeffrey M
authors: JM
authors: Beck
authors: Wei Ji
authors: WJ
authors: Ma
authors: Peter E
authors: PE
authors: Latham
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007858:Learning; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D010465:Perception; D011336:Probability; D012677:Sensation
references: Neural Comput. 2007 May;19(5):1344-61
references: 17381269
references: Trends Cogn Sci. 2001 Jan 1;5(1):10-16
references: 11164731
references: Vision Res. 1999 Oct;39(21):3621-9
references: 10746132
references: Neuron. 2008 Dec 26;60(6):1142-52
references: 19109917
references: Trends Cogn Sci. 2006 Jul;10(7):287-91
references: 16807064
references: Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12491-6
references: 21742982
references: J Opt Soc Am A Opt Image Sci Vis. 2003 Jul;20(7):1434-48
references: 12868647
references: Neural Comput. 2007 Feb;19(2):404-41
references: 17206870
references: Nat Neurosci. 2004 Sep;7(9):907-15
references: 15332089
references: Neural Comput. 2007 Feb;19(2):442-77
references: 17206871
references: Behav Brain Res. 2010 Jan 20;206(2):157-65
references: 19720086
references: Ann N Y Acad Sci. 1969 Apr 21;156(2):872-81
references: 5258022
references: Nat Neurosci. 2011 Jun;14(6):783-90
references: 21552276
references: Biol Cybern. 1999 Jan;80(1):25-44
references: 9951396
references: Nat Neurosci. 1999 Aug;2(8):740-5
references: 10412064
references: Exp Brain Res. 2007 Jun;180(2):303-19
references: 17273872
references: Neural Comput. 2000 May;12(5):1165-87
references: 10905812
references: Exp Brain Res. 1996 Sep;111(2):253-61
references: 8891655
references: Trends Cogn Sci. 2010 Mar;14(3):119-30
references: 20153683
references: Psychol Rev. 2004 Jan;111(1):3-32
references: 14756583
references: Neural Comput. 2003 Aug;15(8):1843-64
references: 14511515
references: Psychol Bull. 2012 May;138(3):389-414
references: 22545686
references: Nat Neurosci. 2010 Oct;13(10):1292-8
references: 20835253
references: Trends Cogn Sci. 2006 Jul;10(7):309-18
references: 16797219
references: Trends Neurosci. 2004 Dec;27(12):712-9
references: 15541511
references: Neural Comput. 2009 Nov;21(11):2991-3009
references: 19635018
references: Science. 1995 Sep 29;269(5232):1880-2
references: 7569931
references: J Neural Eng. 2005 Sep;2(3):S219-34
references: 16135886
references: J Neurosci. 2012 Aug 1;32(31):10618-26
references: 22855811
references: MD Comput. 1991 May-Jun;8(3):157-71
references: 1857193
references: Nat Neurosci. 2011 Feb;14(2):239-45
references: 21217762
references: Cereb Cortex. 2003 Nov;13(11):1257-69
references: 14576217
references: Science. 2011 Mar 11;331(6022):1279-85
references: 21393536
references: Cold Spring Harb Symp Quant Biol. 1990;55:899-910
references: 2132866
references: Science. 2000 Dec 8;290(5498):1968-72
references: 11110664
references: Nature. 2004 Jan 15;427(6971):244-7
references: 14724638
references: Neuron. 2012 Apr 12;74(1):30-9
references: 22500627
references: Curr Biol. 2004 Feb 3;14(3):257-62
references: 14761661
references: Nat Neurosci. 2011 Nov 20;15(1):146-54
references: 22101645
references: Nat Neurosci. 2001 Aug;4(8):826-31
references: 11477429
references: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10687-92
references: 18669663
references: Neuron. 2011 Feb 24;69(4):818-31
references: 21338889
references: Neural Comput. 2004 Jan;16(1):1-38
references: 15006021
references: Behav Brain Sci. 1997 Dec;20(4):723-42; discussion 743-67
references: 10097009
references: J Neurosci. 2002 Nov 15;22(22):9668-78
references: 12427822
references: J Neurosci. 2011 Oct 26;31(43):15310-9
references: 22031877
references: PLoS Biol. 2012;10(3):e1001293
references: 22479152
references: J Neurophysiol. 1996 Oct;76(4):2790-3
references: 8899646
references: Psychol Bull. 2012 May;138(3):415-22
references: 22545687
references: Nat Neurosci. 2006 Nov;9(11):1432-8
references: 17057707
references: J Neurosci. 2007 May 23;27(21):5744-56
references: 17522318
references: Trends Cogn Sci. 2006 Jul;10(7):327-34
references: 16793324
references: Nature. 2006 Jun 22;441(7096):979-83
references: 16791195
references: Nature. 1990 Jan 18;343(6255):263-6
references: 2300170
references: Cognition. 2011 Sep;120(3):380-90
references: 21440889
references: Nat Neurosci. 2006 May;9(5):690-6
references: 16617339
references: J Neurophysiol. 1999 Mar;81(3):1355-64
references: 10085361
references: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5239-44
references: 15795376
references: Neural Comput. 1998 Feb 15;10(2):403-30
references: 9472488
references: Behav Brain Sci. 1997 Dec;20(4):537-56; discussion 556-96
references: 10097006
references: Nature. 2002 Jan 24;415(6870):429-33
references: 11807554
references: Vision Res. 1998 Jun;38(11):1655-82
references: 9747502
references: Neural Comput. 2007 Feb;19(2):371-403
references: 17206869