title: Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia.
abstract: OBJECTIVE
  To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia.
  
  
  METHODS
  The level of serum and urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), retinol-binding protein (RBP) and interleukin-18 (IL-18) were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The level of serum cystatin C, urine RBP, urine NGAL and urine KIM-1 in preeclampsia group were higher than that in the normal pregnancy group. When four biomarkers are combined, the sensitivity and specificity are 100%/98.20%.
  
  
  CONCLUSIONS
  Urine KIM-1 is the most potential biomarker for renal injury in preeclampsia. The more biomarkers combined, the more sensitivity and specificity were increased.
authors: Division of Nephrology, The Fifth People's Hospital of Shanghai, Fudan University , Shanghai , People's Republic of China .
authors: Jing
authors: J
authors: Xiao
authors: Jianying
authors: J
authors: Niu
authors: Xianwu
authors: X
authors: Ye
authors: Qianqian
authors: Q
authors: Yu
authors: Yong
authors: Y
authors: Gu
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood; D005260:Female; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000097:blood / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood / Q000652:urine; D008562:Membrane Glycoproteins / Q000097:blood / Q000652:urine; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine*; D011247:Pregnancy; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000652:urine; D011991:Receptors, Virus / Q000097:blood; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism*; D012177:Retinol-Binding Proteins / Q000652:urine; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D012177:Retinol-Binding Proteins