title: Which immune cells matter? The immunopathogenesis of multiple sclerosis.
abstract: Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.
authors: Hasselt University, Biomedical Research Institute and transnationale Universiteit Limburg, School of Life Sciences, 3590 Diepenbeek, Belgium.
authors: Bieke
authors: B
authors: Broux
authors: Piet
authors: P
authors: Stinissen
authors: Niels
authors: N
authors: Hellings
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*