title: Physical activity in different periods of life, sedentary behavior, and the risk of ovarian cancer in the NIH-AARP diet and health study.
abstract: BACKGROUND
  Physical activity and sedentary behavior may influence ovarian cancer risk, but clear evidence is lacking.
  
  
  METHODS
  We prospectively investigated the relations of self-reported physical activity and sedentary behavior to ovarian cancer incidence in a cohort of 148,892 U.S. women ages 50-71 years at baseline (1995-1996), who were followed through 2006. Multivariate Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI). We also conducted analysis by hormone use, body mass index (BMI), and cancer subtype.
  
  
  RESULTS
  We identified 753 incident epithelial ovarian cancers. Overall, neither physical activity nor sedentary behavior at baseline was associated with ovarian cancer risk. Compared with women who never or rarely engaged in vigorous physical activity in the past year, women who reported more than 5 times/week of vigorous physical activity had an RR of 1.05 (95% CI, 0.84-1.32). Women who sat 7+ hours/day had an RR of 1.05 (95% CI, 0.80-1.37) compared with those reporting <3 hours of sitting. The associations were not modified by hormone use or BMI and were similar for both serous and non-serous subtypes.
  
  
  CONCLUSIONS
  Physical activity and sedentary behavior in middle and older ages were not associated with ovarian cancer risk.
  
  
  CONCLUSIONS
  We found no clear support for a role of physical activity and sedentary behavior in ovarian cancer risk.
authors: Authors' Affiliations: Nutritional Epidemiology Branch, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; and AARP, Washington, District of Columbia.
authors: Qian
authors: Q
authors: Xiao
authors: Hannah P
authors: HP
authors: Yang
authors: Nicolas
authors: N
authors: Wentzensen
authors: Albert
authors: A
authors: Hollenbeck
authors: Charles E
authors: CE
authors: Matthews
mesh_terms: D000367:Age Factors; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009043:Motor Activity; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology*; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D057185:Sedentary Behavior; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
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