title: Serum cystatin C and tubular urinary enzymes as biomarkers of renal dysfunction in type 2 diabetes mellitus.
abstract: Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. The aim of this study was to assess serum cystatin C and 2 renal tubular enzymes, neutrophil gelatinase associated lipocalin (NGAL) and N-acetyl-beta-D-glucosaminidase (NAG), as screening markers for early renal dysfunction in patients with type 2 diabetes mellitus (T2DM). ROC curve analysis showed that urinary NAG is the most sensitive marker of microalbuminuria and early renal damage with sensitivity of 83.3%, while serum cystatin C was the most sensitive and specific marker of macroalbuminuria and damage progress with sensitivity of 70.8% and specificity of 83.3% versus 70.6% and 83.3% for uNGAL; and 64.7% and 66.7% for NAG, respectively. Our data indicate that urinary NAG is the most sensitive marker for early renal damage in diabetic patients. However, for damage progress, serum cystatin C is the most sensitive and specific marker for follow-up and monitoring renal dysfunction.
authors: Department of Internal Medicine, Medical Research Division, National Research Centre, Egypt.
authors: Heba S
authors: HS
authors: Assal
authors: Salwa
authors: S
authors: Tawfeek
authors: Enas A
authors: EA
authors: Rasheed
authors: Dalia
authors: D
authors: El-Lebedy
authors: Eman H
authors: EH
authors: Thabet
keywords: N-acetyl-beta-D-glucosaminidase; cystatin C; diabetic nephropathy; neutrophil gelatinase-associated lipocalin
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