title: A quantitative comparison of the performance of three deformable registration algorithms in radiotherapy.
abstract: We present an evaluation of various non-rigid registration algorithms for the purpose of compensating interfractional motion of the target volume and organs at risk areas when acquiring CBCT image data prior to irradiation. Three different deformable registration (DR) methods were used: the Demons algorithm implemented in the iPlan Software (BrainLAB AG, Feldkirchen, Germany) and two custom-developed piecewise methods using either a Normalized Correlation or a Mutual Information metric (featureletNC and featureletMI). These methods were tested on data acquired using a novel purpose-built phantom for deformable registration and clinical CT/CBCT data of prostate and lung cancer patients. The Dice similarity coefficient (DSC) between manually drawn contours and the contours generated by a derived deformation field of the structures in question was compared to the result obtained with rigid registration (RR). For the phantom, the piecewise methods were slightly superior, the featureletNC for the intramodality and the featureletMI for the intermodality registrations. For the prostate cases in less than 50% of the images studied the DSC was improved over RR. Deformable registration methods improved the outcome over a rigid registration for lung cases and in the phantom study, but not in a significant way for the prostate study. A significantly superior deformation method could not be identified.
authors: Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, AKH-4L, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
authors: Daniella
authors: D
authors: Fabri
authors: Valentina
authors: V
authors: Zambrano
authors: Amon
authors: A
authors: Bhatia
authors: Hugo
authors: H
authors: Furtado
authors: Helmar
authors: H
authors: Bergmann
authors: Markus
authors: M
authors: Stock
authors: Christoph
authors: C
authors: Bloch
authors: Carola
authors: C
authors: Lütgendorf-Caucig
authors: Supriyanto
authors: S
authors: Pawiro
authors: Dietmar
authors: D
authors: Georg
authors: Wolfgang
authors: W
authors: Birkfellner
authors: Michael
authors: M
authors: Figl
mesh_terms: D000465:Algorithms; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D006801:Humans; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
keywords: Deformable registration; Deformierbare Registrierung; Organbewegung; Radiotherapie; organ motion; radiotherapy
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