title: Demonic axe-like conjugated alkynes in combating microbes.
abstract: A new series of disubstituted alkynes was obtained by microwave induced internal splitting of the corresponding β-oxo-alkylidenetriphenylphosphoranes. The antimicrobial potential of these conjugated alkynes and phosphoranes was assayed in vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis), three Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and five fungal strains (Aspergillus niger, Candida albicans, Aspergillus flavus, Candida rugosa, Saccharomyces cerevisiae). The 3-pyridylalkyne derivatives viz., 3-(6-chloropyridin-3-yl)propynenitrile (6a), 3-(2-chloropyridin-3-yl)propynenitrile (6b), ethyl 3-(6-chloropyridin-3-yl)propiolate (6c), iso-propyl 3-(6-chloropyridin-3-yl)propiolate (6d) and 3-(2,6-dichloro-5-fluoropyridin-3-yl)propynenitrile (6e) were found to be highly potent towards all tested microorganisms except E. coli.
authors: Fluoroorganics Division, CSIR-Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad 500607, Andhra Pradesh, India.
authors: Jayaram Reddy
authors: JR
authors: Komsani
authors: Satish
authors: S
authors: Koppireddi
authors: Sreenivas
authors: S
authors: Avula
authors: Pranay Kumar
authors: PK
authors: Koochana
authors: Rambabu
authors: R
authors: Yadla
mesh_terms: D000114:Acetylene / Q000737:chemistry / Q000494:pharmacology; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000114:Acetylene
keywords: Alkyl halopyridylpropynoic acid ester; Antimicrobial activity; Halopyridylpropynenitrile; iso-Propyl bromotriphenylphosphoranylacetic acid ester; α-Nicotinoyl-α-(alkoxycarbonyl)methylenetriphenylphosphoranes; β-Oxo-alkylidene-triphenylphosphoranes