title: Polyketides with New Delhi metallo-β-lactamase 1 inhibitory activity from Penicillium sp.
abstract: Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-β-lactamase 1 with IC₅₀ values of 94.9 and 87.9 μM, respectively.
authors: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors: Maoluo
authors: M
authors: Gan
authors: Yufeng
authors: Y
authors: Liu
authors: Yinlei
authors: Y
authors: Bai
authors: Yan
authors: Y
authors: Guan
authors: Li
authors: L
authors: Li
authors: Rongmei
authors: R
authors: Gao
authors: Weiying
authors: W
authors: He
authors: Xuefu
authors: X
authors: You
authors: Yuhuan
authors: Y
authors: Li
authors: Liyan
authors: L
authors: Yu
authors: Chunling
authors: C
authors: Xiao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D058441:Rhizosphere; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases
chemical_list: D000470:Alkaloids; D061065:Polyketides; D015363:Quinolones; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1