title: The genomics of incompatibility factors and sex determination in hybridizing species of Cottus (Pisces).
abstract: Cottus rhenanus and Cottus perifretum have formed hybrid lineages and narrow hybrid zones that can be best explained through the action of natural selection. However, the underlying selective forces as well as their genomic targets are not well understood. This study identifies genomic regions in the parental species that cause hybrid incompatibilities and tests whether these manifest in a sex-specific manner to learn about processes that affect natural hybridization in Cottus. Interspecific F2 crosses were analyzed for 255 markers for genetic mapping and to detect transmission distortion as a sign for genetic incompatibilities. The Cottus map consists of 24 linkage groups with a total length of 1575.4 cM. A male heterogametic (XY) sex determination region was found on different linkage groups in the two parental species. Genetic incompatibilities were incomplete, varied among individuals and populations and were not associated with the heterogametic sex. The variance between populations and individuals makes it unlikely that there are species-specific incompatibility loci that could affect the gene pool of natural hybrids in a simple and predictable way. Conserved synteny with sequenced fish genomes permits to genetically study the Cottus genome through the transfer of genomic information from the model fish species. Homology relationships of candidate genomic regions in Cottus indicate that sex determination is not based on the same genomic regions found in other fish species. This suggests a fast evolutionary turnover of the genetic basis of sex determination that, together with the small size of the heterogametic regions, may contribute to the absence of fitness effects related to the Haldane's rule.
authors: Evolutionary Genetics of Fishes, Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Biology, Plön, Germany.
authors: J
authors: J
authors: Cheng
authors: T
authors: T
authors: Czypionka
authors: A W
authors: AW
authors: Nolte
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D023281:Genomics; D006824:Hybridization, Genetic; D008297:Male; D010473:Perciformes / Q000235:genetics* / Q000502:physiology; D019849:Sex Determination Processes
references: Mol Ecol. 2012 Jun;21(12):3032-47
references: 22582810
references: Evolution. 2010 Mar 1;64(3):617-33
references: 19796149
references: PLoS Genet. 2009 Feb;5(2):e1000391
references: 19229325
references: Mol Ecol. 2011 May;20(10):2044-72
references: 21476991
references: Mol Phylogenet Evol. 2008 Jan;46(1):224-36
references: 17709262
references: Mol Ecol. 2000 Jun;9(6):709-22
references: 10849287
references: J Evol Biol. 2005 Nov;18(6):1619-24
references: 16313473
references: Philos Trans R Soc Lond B Biol Sci. 2010 Jun 12;365(1547):1783-800
references: 20439281
references: Mar Biotechnol (NY). 2008 May-Jun;10(3):227-33
references: 18297360
references: Genome Biol. 2008;9(2):R30
references: 18269752
references: Nat Rev Genet. 2001 May;2(5):370-81
references: 11331903
references: Proc Biol Sci. 2005 Nov 22;272(1579):2379-87
references: 16243698
references: Heredity (Edinb). 2009 Jan;102(1):4-15
references: 18781167
references: Nat Methods. 2008 Feb;5(2):183-8
references: 18204455
references: Genetics. 2008 Jul;179(3):1479-95
references: 18562642
references: Genetics. 2007 Apr;175(4):2039-42
references: 17287528
references: Annu Rev Genet. 2011;45:331-55
references: 21910629
references: Chromosome Res. 2008;16(5):801-11
references: 18607761
references: Sex Dev. 2009;3(2-3):88-98
references: 19684454
references: Mol Ecol. 2009 Jun;18(12):2615-27
references: 19457191
references: Genetics. 2008 Sep;180(1):409-20
references: 18723891
references: Mol Ecol. 2006 Jun;15(7):1983-93
references: 16689913
references: Evolution. 2005 Aug;59(8):1754-67
references: 16329245
references: Mol Ecol. 2012 Oct;21(19):4797-810
references: 22650446
references: Proc Biol Sci. 2003 Jan 7;270(1510):53-9
references: 12590771
references: FEBS J. 2011 Apr;278(7):1010-9
references: 21281449
references: Mol Ecol. 2011 Apr;20(7):1475-91
references: 21251111
references: Nature. 2007 Mar 15;446(7133):279-83
references: 17361174
references: Genetics. 2009 Dec;183(4):1385-95
references: 19786620
references: Evolution. 1999 Dec;53(6):1757-1768
references: 28565458
references: Genetics. 2011 Sep;189(1):289-304
references: 21750261
references: Heredity (Edinb). 2013 Jan;110(1):63-70
references: 23047202
references: Genome Res. 2001 Jan;11(1):55-66
references: 11156615
references: Philos Trans R Soc Lond B Biol Sci. 2010 Jun 12;365(1547):1717-33
references: 20439277
references: Genetics. 2003 May;164(1):359-72
references: 12750346
references: Trends Genet. 2010 Feb;26(2):54-8
references: 20044166
references: J Evol Biol. 2013 Feb;26(2):229-46
references: 23323997
references: Science. 1998 Sep 25;281(5385):1990-4
references: 9748152
references: Mol Phylogenet Evol. 2009 Feb;50(2):345-63
references: 19059489
references: Sex Dev. 2009;3(2-3):60-7
references: 19684451