title: New perspectives in nuclear neurology for the evaluation of Parkinson's disease.
abstract: The pathophysiology of Parkinson's disease (PD) has not yet been completely elucidated. However, during the past few years, significant progress has been made in understanding the intra- and extracellular mechanisms by which proteins such as alpha-synuclein and neuroinflammatory molecules may display impaired function and/or expression in PD. Recent developments in imaging techniques based on positron emission tomography (PET) and single photon emission computed tomography (SPECT) now allow the non-invasive tracking of such molecular targets of known relevance to PD in vivo. This article summarizes recent PET and SPECT studies of new radiopharmaceuticals and discusses their potential role and perspectives for use in the fields of new drug development and early diagnosis for PD, as well to aid in differential diagnosis and monitoring of the progression of PD.
authors: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, Rua Dr. Ovídio Pires de Campos, CMN - Centro de Medicina Nuclear, São Paulo, SP, Brasil Núcleo de Apoio à Pesquisa em Neurociência Aplicada (NAPNA), Universidade de São Paulo, SP, Brasil.
authors: Marcel
authors: M
authors: Benadiba
authors: Gert
authors: G
authors: Luurtsema
authors: Vitor
authors: V
authors: Tumas
authors: Carlos Alberto
authors: CA
authors: Buchpigel
authors: Geraldo F
authors: GF
authors: Busatto
mesh_terms: D063388:Endocannabinoids / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D057054:Molecular Imaging; D009462:Neurology / Q000379:methods*; D009473:Neuronal Plasticity / Q000502:physiology; D009683:Nuclear Medicine / Q000379:methods*; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000276:immunology / Q000378:metabolism; D049268:Positron-Emission Tomography; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated