title: Utility of cystatin C as a marker for the severity of aortic regurgitation in hypertensive patients.
abstract: BACKGROUND
  Cystatin C, a cathepsin inhibitor, is involved in the remodeling of human aortic valve and left ventricle (LV).
  
  
  OBJECTIVE
  Cystatin C may be related to the severity of aortic regurgitation (AR).
  
  
  METHODS
  We measured cystatin C and CRP in hypertensive patients with mild-to-moderate AR (n=120) and in those without AR (n=128). Echocardiography was performed to assess the vena contracta width (the narrowest region of regurgitant jet, VCW) as a marker of the severity of AR, relative wall thickness as a marker of LV concentric remodeling, and the ratio of early peak mitral flow to early diastolic mitral annular velocity (E/e') as an index of LV diastolic function. Glomerular filtration rate (GFR) was estimated using the MDRD methods.
  
  
  RESULTS
  Cystatin C levels were greater in hypertensive patients with AR than in those without AR. A multiple linear regression analysis indicated cystatin C levels correlated with the VCW independent of GFR, body mass index, CRP, relative wall thickness, and E/e' in hypertensive patients with AR.
  
  
  CONCLUSIONS
  Cystatin C was associated with the severity of regurgitation independent of renal function body composition chronic inflammation LV remodeling and diastolic function in hypertensive patients with mild-to-moderate AR.
authors: Department of Cardiology, Mitsubishi Nagoya Hospital, Nagoya, Japan. Electronic address: masato2_iida@mhi.co.jp.
authors: Masato
authors: M
authors: Iida
authors: Mitsuru
authors: M
authors: Yamamoto
authors: Yuko S
authors: YS
authors: Ishiguro
authors: Masatoshi
authors: M
authors: Yamazaki
authors: Norihiro
authors: N
authors: Ueda
authors: Haruo
authors: H
authors: Honjo
authors: Kaichirou
authors: K
authors: Kamiya
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D001022:Aortic Valve Insufficiency / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000378:metabolism; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D012720:Severity of Illness Index; D014463:Ultrasonography; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D002097:C-Reactive Protein
keywords: Aortic regurgitation; CRP; Cystatin C; Echocardiography; Hypertension; Vena contracta width