title: Abiotrophia defectiva bleb-associated endophthalmitis confirmed with 16s ribosomal RNA sequencing.
abstract: One recognized complication of trabeculectomy with visually devastating potential is blebitis. We present a case of a 74-year-old woman with a culture and polymerase chain reaction-positive Abiotrophia defectiva bleb-associated endophthalmitis. Abiotrophia defectiva is a rare but possible cause of endophthalmitis secondary to blebitis and should be considered in culture-negative cases. Prompt identification, hence directed eradication, of the causative organism in such visually threatening cases may be facilitated by requesting polymerase chain reaction and 16S ribosomal RNA sequencing.
authors: *University of New South Wales †Department of Ophthalmology, Liverpool Hospital, Liverpool §Glaucoma Unit, Sydney Eye Hospital, Sydney, NSW, Australia ‡Moorfields Eye Hospital, London, UK.
authors: Ming-Han
authors: MH
authors: Hugo Lee
authors: Mitchell
authors: M
authors: Lawlor
authors: Anne J
authors: AJ
authors: Lee
mesh_terms: D058835:Abiotrophia; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001285:Atropine / Q000008:administration & dosage; D002442:Ceftazidime / Q000627:therapeutic use; D002512:Cephalothin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D058449:Intravitreal Injections; D019654:Lens Implantation, Intraocular; D009184:Mydriatics / Q000008:administration & dosage; D018918:Phacoemulsification; D016133:Polymerase Chain Reaction; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S; D019738:Surgically-Created Structures / Q000382:microbiology*; D014130:Trabeculectomy; D014640:Vancomycin / Q000627:therapeutic use; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D009184:Mydriatics; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D014640:Vancomycin; D001285:Atropine; D002442:Ceftazidime; D002512:Cephalothin