title: Antitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogels.
abstract: Degradable hybrid hydrogels with improved stability are prepared by incorporating nanodisks of biocompatible laponite (LP) in alginate (AG) hydrogels using Ca(2+) as a crosslinker. The Dox-loaded hybrid hydrogels give a controlled Dox release at physiological environment in a sustained manner. Under conditions that mimic the tumor environment, both the sustainability in the Dox release (up to 17 d) and the release efficiency from LP/AG-Dox hydrogels are improved. The in situ degradation of these hybrid hydrogels gives rise to nanohybrids that might serve as vehicles for carrying Dox through the cell membrane and diminish the effect of Dox ion-trapping in the acidic extracellular environment of the tumor and/or in the endo-lysosomal cell compartments.
authors: CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal.
authors: Mara
authors: M
authors: Gonçalves
authors: Priscilla
authors: P
authors: Figueira
authors: Dina
authors: D
authors: Maciel
authors: João
authors: J
authors: Rodrigues
authors: Xiangyang
authors: X
authors: Shi
authors: Helena
authors: H
authors: Tomás
authors: Yulin
authors: Y
authors: Li
mesh_terms: D000464:Alginates / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology; D017640:Silicates / Q000737:chemistry
chemical_list: D000464:Alginates; D000903:Antibiotics, Antineoplastic; D006603:Hexuronic Acids; D020100:Hydrogels; D017640:Silicates; D004317:Doxorubicin; D020723:Glucuronic Acid; C524813:laponite
keywords: alginate; doxorubicin; drug delivery systems; hydrogels; laponite