title: Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
abstract: It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those stress reactions during the scanning procedure may influence task performance and neural correlates. However, the question how sympathetic arousal elicited by the scanning procedure itself may act as a potential confounder of fMRI data remains unresolved today. Thirty-seven scanner naive healthy subjects performed a simple cued target detection task. Levels of salivary alpha amylase (sAA), as a biomarker for sympathetic activity, were assessed in samples obtained at several time points during the lab visit. SAA increased two times, immediately prior to scanning and at the end of the scanning procedure. Neural activation related to motor preparation and timing as well as task performance was positively correlated with the first increase. Furthermore, the first sAA increase was associated with task induced deactivation (TID) in frontal and parietal regions. However, these effects were restricted to the first part of the experiment. Consequently, this bias of scanner related sympathetic activation should be considered in future fMRI investigations. It is of particular importance for pharmacological investigations studying adrenergic agents and the comparison of groups with different stress vulnerabilities like patients and controls or adolescents and adults.
authors: Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universität Dresden, Dresden, Germany. muehlhan@klipsy.tu-dresden.de
authors: Markus
authors: M
authors: Muehlhan
authors: Ulrike
authors: U
authors: Lueken
authors: Jens
authors: J
authors: Siegert
authors: Hans-Ulrich
authors: HU
authors: Wittchen
authors: Michael N
authors: MN
authors: Smolka
authors: Clemens
authors: C
authors: Kirschbaum
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001519:Behavior; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D008297:Male; D055291:Salivary alpha-Amylases / Q000096:biosynthesis; D013315:Stress, Psychological; D013564:Sympathetic Nervous System / Q000502:physiology*; D055815:Young Adult
chemical_list: D055291:Salivary alpha-Amylases
references: Int J Psychophysiol. 2000 Apr;36(1):59-68
references: 10700623
references: Brain Res Brain Res Rev. 2003 Apr;42(1):33-84
references: 12668290
references: Int J Psychophysiol. 2009 Aug;73(2):88-94
references: 19414044
references: Annu Rev Neurosci. 1987;10:67-95
references: 3551766
references: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references: 11209064
references: Physiol Rev. 2009 Apr;89(2):535-606
references: 19342614
references: Neuroimage. 2008 Aug 1;42(1):196-206
references: 18538585
references: Psychoneuroendocrinology. 2009 May;34(4):486-96
references: 19249160
references: Neuroimage. 2012 Sep;62(3):1489-98
references: 22634217
references: Int J Psychophysiol. 2011 Feb;79(2):118-26
references: 20875462
references: Psychoneuroendocrinology. 2008 May;33(4):517-29
references: 18337016
references: Hum Brain Mapp. 2005 Sep;26(1):15-29
references: 15852468
references: Can J Neurol Sci. 2007 Feb;34(1):11-7
references: 17352342
references: Neuroimage. 2001 Nov;14(5):1070-9
references: 11697938
references: Neuroimage. 2004 May;22(1):315-22
references: 15110021
references: Neuroimage. 2005 Mar;25(1):1-7
references: 15734338
references: Front Hum Neurosci. 2013 Jan 16;6:349
references: 23335893
references: J Magn Reson Imaging. 2003 Apr;17(4):463-71
references: 12655586
references: Psychoneuroendocrinology. 2009 Sep;34(8):1242-6
references: 19346079
references: J Cereb Blood Flow Metab. 2001 May;21(5):592-607
references: 11333370
references: Neuropsychologia. 2000;38(6):808-19
references: 10689056
references: Hum Brain Mapp. 2006 Nov;27(11):889-95
references: 16544325
references: Lancet. 1988 Aug 27;2(8609):512
references: 2900435
references: Neuroimage. 2010 Apr 15;50(3):1313-9
references: 20056157
references: Soc Cogn Affect Neurosci. 2009 Dec;4(4):423-8
references: 20035017
references: J Comp Neurol. 2005 Dec 5;493(1):154-66
references: 16254997
references: Neuroimage. 2011 Mar 1;55(1):216-24
references: 21126587
references: J Behav Ther Exp Psychiatry. 1994 Jun;25(2):131-4
references: 7983222
references: Hum Brain Mapp. 2007 Dec;28(12):1287-301
references: 17290371
references: Psychoneuroendocrinology. 2008 Nov;33(10):1378-86
references: 18790572
references: PLoS One. 2011 Apr 05;6(4):e18009
references: 21483666
references: Cereb Cortex. 2010 Nov;20(11):2636-46
references: 20154013
references: Ann N Y Acad Sci. 2010 Mar;1191:133-55
references: 20392279
references: Brain Res Bull. 2006 Oct 16;70(4-6):263-9
references: 17027761
references: J Neurosci. 2012 Jan 25;32(4):1481-7
references: 22279232
references: Psychiatry Res. 2010 May 30;182(2):160-4
references: 20409694
references: Magn Reson Imaging. 1997;15(3):301-6
references: 9201677
references: Biol Psychiatry. 2009 Jul 1;66(1):25-32
references: 19403118
references: Eur Neuropsychopharmacol. 2011 Jul;21(7):516-25
references: 21269812
references: Learn Mem. 2009 Sep 30;16(10):625-34
references: 19794188
references: Psychoneuroendocrinology. 2006 Jan;31(1):137-41
references: 16046076
references: J Psychiatry Neurosci. 2013 Mar;38(2):84-96
references: 22964258
references: JAMA. 1993 Aug 11;270(6):745-7
references: 8336378
references: Nature. 1996 Mar 28;380(6572):291
references: 8598925
references: Clin Radiol. 1995 Mar;50(3):137-43
references: 7889700
references: Psychoneuroendocrinology. 2012 Aug;37(8):1299-308
references: 22309826
references: Psychol Sci. 2010 Feb;21(2):298-304
references: 20424060
references: J Pediatr Gastroenterol Nutr. 2012 Apr;54(4):454-62
references: 22193178
references: Pain. 2010 Jun;149(3):453-462
references: 20417032
references: Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1215-28
references: 10466147
references: Neuroinformatics. 2009 Spring;7(1):73-82
references: 19140033
references: Neuroimage. 2010 Apr 1;50(2):847-54
references: 20004250
references: Neuropsychologia. 2007 Mar 2;45(4):673-84
references: 17014871
references: J Cogn Neurosci. 2007 Mar;19(3):468-78
references: 17335395
references: Neuroimage. 2005 Apr 15;25(3):661-7
references: 15808967