title: Which neuromuscular attributes are most associated with mobility among older primary care patients?
abstract: OBJECTIVE
  To identify the neuromuscular attributes that are associated with self-reported mobility status among older primary care patients.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Metropolitan-based health care system.
  
  
  METHODS
  Community-dwelling primary care patients aged ≥65 years (N=430), with self-reported modification of mobility tasks resulting from underlying health conditions.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Basic and Advanced Lower Extremity Function as measured by the Late Life Function and Disability Instrument.
  
  
  RESULTS
  We constructed multivariable linear regression models evaluating both outcomes. For Basic Lower Extremity Function, leg strength, leg velocity, trunk extensor muscle endurance, and ankle range of motion (ROM) were statistically significant predictors (P<.001, R(2)=.21). For Advanced Lower Extremity Function, leg strength, leg strength asymmetry, leg velocity, trunk extensor muscle endurance, and knee flexion ROM were statistically significant predictors (P<.001, R(2)=.39). Sensitivity analyses conducted using multiple imputations to account for missing data confirmed these findings.
  
  
  CONCLUSIONS
  This analysis highlights the relevance and importance of 5 categories of neuromuscular attributes: strength, speed of movement, ROM, asymmetry, and trunk stability. It identifies novel attributes (leg velocity and trunk extensor muscle endurance) relevant to mobility and highlights that impairment profiles vary by the level of mobility assessed. These findings will inform the design of more thorough and potentially more effective disability prevention strategies.
authors: Spaulding Rehabilitation Hospital, Boston, MA. Electronic address: jfbean@partners.org.
authors: Jonathan F
authors: JF
authors: Bean
authors: Boston University, Boston, MA.
authors: Nancy K
authors: NK
authors: Latham
authors: Spaulding Rehabilitation Hospital, Boston, MA.
authors: Nicole
authors: N
authors: Holt
authors: Spaulding Rehabilitation Hospital, Boston, MA.
authors: Laura
authors: L
authors: Kurlinksi
authors: Boston University, Boston, MA.
authors: Pensheng
authors: P
authors: Ni
authors: University of Massachusetts Boston, Boston, MA.
authors: Suzanne
authors: S
authors: Leveille
authors: Massachusetts General Hospital, Boston, MA.
authors: Sanja
authors: S
authors: Percac-Lima
authors: Boston University, Boston, MA.
authors: Alan
authors: A
authors: Jette
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000843:Ankle Joint / Q000502:physiology; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D008124:Locomotion / Q000502:physiology*; D035002:Lower Extremity / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D053580:Muscle Strength / Q000502:physiology; D011320:Primary Health Care; D016059:Range of Motion, Articular / Q000502:physiology
keywords: 1 repetition maximum; 1RM; Aged; BWH; Boston RISE; Boston Rehabilitative Impairment Study of the Elderly; Brigham and Women's Hospital; Health ABC; Health Aging and Body Composition Study; LLFDI; Late Life Function and Disability Instrument; MGH; Massachusetts General Hospital; Mobility limitation; Primary health care; ROM; Rehabilitation; SPPB; Short Physical Performance Battery; range of motion
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