title: Update on the pathogenesis of Haemophilus parasuis infection and virulence factors.
abstract: Haemophilus parasuis is the causative agent of Glässer's disease in pigs, a severe systemic disease that has led to increasing economic losses in the pig industry worldwide. The H. parasuis genome sequence has been completed, but the function and essentiality of the annotated genes remain largely unknown, especially virulence factors. The recent developments in the efficient genetic manipulation of H. parasuis have greatly facilitated the study of gene function, pathogenesis mechanisms and virulence factors. In this review, we provided update information regarding that (i) how the pathogen overcome host immune responses and cell barriers which were tightly associated with the pathogenesis, and (ii) the several recent identification of virulence factors were involved in evading the immune responses and cell barriers in H. parasuis.
authors: College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, PR China; Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China.
authors: Bin
authors: B
authors: Zhang
authors: College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, PR China.
authors: Cheng
authors: C
authors: Tang
authors: Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China. Electronic address: mliao@scau.edu.cn.
authors: Ming
authors: M
authors: Liao
authors: College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, PR China. Electronic address: yhua900@163.com.
authors: Hua
authors: H
authors: Yue
mesh_terms: D000818:Animals; D006192:Haemophilus Infections / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology*; D044137:Haemophilus parasuis / Q000201:enzymology / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D013552:Swine; D037521:Virulence Factors / Q000276:immunology*
chemical_list: D037521:Virulence Factors
keywords: Haemophilus parasuis, Pathogenesis mechanisms, Virulence factors