title: Identification of the effects of aging-related gene-matrix metalloproteinase on allograft outcomes in kidney transplantation.
abstract: BACKGROUND
  Aging plays a profound role in the ability of the kidney to function. Aging which varies among individuals, has been associated with the matrix metalloproteinase (MMP) 7 and 20 genes. This study was conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in MMP7 (A>T) and rs1711437 in MMP20 (G>A)] and transplant outcomes in 235 recipients.
  
  
  METHODS
  Transplant outcomes were evaluated according to the sum of the A alleles in the recipients and the donors. The group with a high number of A alleles (≥3) was compared with the group with a low number (<3).
  
  
  RESULTS
  The group with a high number of MMP7 A alleles showed a lower risk of chronic tubulointerstitial lesion than the group with a low number (P = .009). The group with a high number of MMP20 A alleles had showed better long-term kidney function at 10 years after transplantation than the group with a low number (P = .026). Furthermore, the group with a high number of MMP20 A alleles showed a trend toward better graft survival compared with the group with a low number, especially among recipients followed for >1 year (P = .022).
  
  
  CONCLUSIONS
  Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: S S
authors: SS
authors: Han
authors: H
authors: H
authors: Lee
authors: Y J
authors: YJ
authors: Oh
authors: J P
authors: JP
authors: Lee
authors: S
authors: S
authors: Kim
authors: J
authors: J
authors: Ha
authors: S J
authors: SJ
authors: Kim
authors: M H
authors: MH
authors: Park
authors: Y S
authors: YS
authors: Kim
authors: D K
authors: DK
authors: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006085:Graft Survival / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D053519:Matrix Metalloproteinase 20 / Q000235:genetics*; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C507111:MMP20 protein, human; D053519:Matrix Metalloproteinase 20; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7