title: Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology.
abstract: Microglia, the major resident immune cells in the central nervous system (CNS) are considered as the key cellular mediators of neuroinflammatory processes. In the past few years, microglial research has become a main focus in cellular neuroimmunology and neuroinflammation. Chronic/remitting neurological disease such as multiple sclerosis (MS) has long been considered an inflammatory autoimmune disease with the infiltration of peripheral myelin-specific T cells into the CNS. With the rapid advancement in the field of microglia and astrocytic neurobiology, the term neuroinflammation progressively started to denote chronic CNS cell-specific inflammation in MS. The direct glial responses in MS are different from conventional peripheral immune responses. This review attempts to summarize current findings of neuroinflammatory responses within the CNS by direct infection of neural cells by mouse hepatitis virus (MHV) and the mechanisms by which glial cell responses ultimately contribute to the neuropathology on demyelination. Microglia can be persistently infected by MHV. Microglial activation and phagocytosis are recognized to be critically important in the pathogenesis of demyelination. Emerging evidence for the pathogenic role of microglia and the activation of inflammatory pathways in these cells in MHV infection supports the concept that microglia induced neuroinflammation is an amplifier of virus-induced neuropathology.
authors: Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, India, dassarmaj@iiserkol.ac.in.
authors: Jayasri
authors: J
authors: Das Sarma
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000821:virology; D018352:Coronavirus Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D017628:Microglia / Q000276:immunology* / Q000473:pathology / Q000821:virology; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D006517:Murine hepatitis virus / Q000276:immunology*
references: J Neurosci. 2009 Oct 28;29(43):13435-44
references: 19864556
references: Curr Opin Neurol. 2002 Jun;15(3):349-54
references: 12045736
references: Glia. 2002 Nov;40(2):133-9
references: 12379901
references: N Engl J Med. 2006 Mar 2;354(9):942-55
references: 16510748
references: Nat Med. 1997 Oct;3(10):1133-6
references: 9334726
references: Brain Pathol. 1996 Jul;6(3):259-74
references: 8864283
references: Dev Neurosci. 1999;21(6):491-505
references: 10640867
references: J Neurovirol. 2002 Jun;8(3):257-64
references: 12053280
references: J Virol. 2000 Oct;74(19):9206-13
references: 10982367
references: J Neuroimmunol. 2000 May 1;104(2):109-15
references: 10713349
references: J Neuropathol Exp Neurol. 1997 Nov;56(11):1262-8
references: 9370237
references: Curr Immunol Rev. 2009 May 4;5(4):267-276
references: 19946572
references: J Virol. 2001 Oct;75(20):9780-9
references: 11559811
references: J Clin Invest. 2007 Jan;117(1):89-93
references: 17200712
references: Lab Anim Sci. 1996 Oct;46(5):482-92
references: 8905579
references: Cent Nerv Syst Agents Med Chem. 2009 Dec;9(4):307-30
references: 20021364
references: Nat Rev Immunol. 2002 Feb;2(2):85-95
references: 11910899
references: J Virol. 2008 Sep;82(17):8882-6
references: 18579591
references: Glia. 2005 Apr 15;50(2):121-31
references: 15657941
references: Cell. 2009 Apr 3;137(1):47-59
references: 19345186
references: Virology. 1992 Nov;191(1):517-22
references: 1413526
references: Sci Am. 1995 Nov;273(5):54-5, 58-61
references: 8966536
references: Exp Mol Pathol. 2001 Aug;71(1):1-12
references: 11502093
references: J Virol. 2002 Nov;76(21):10905-13
references: 12368333
references: Nat Rev Neurosci. 2006 Jan;7(1):75-84
references: 16371952
references: J Neurosci Res. 2004 Jul 1;77(1):1-8
references: 15197750
references: J Inflamm (Lond). 2011 Apr 28;8:9
references: 21526997
references: J Immunol. 2000 Aug 15;165(4):2278-86
references: 10925317
references: J Virol. 1984 Aug;51(2):563-6
references: 6086966
references: Trends Immunol. 2004 Dec;25(12):677-86
references: 15530839
references: Annu Rev Immunol. 2005;23:683-747
references: 15771584
references: Glia. 2002 Nov;40(2):240-51
references: 12379911
references: Nat Rev Immunol. 2011 Oct 14;11(11):723-37
references: 21997792
references: Front Cell Neurosci. 2013 Apr 08;7:34
references: 23596391
references: Interdiscip Perspect Infect Dis. 2010;2010:109239
references: 20652053
references: J Neuropathol Exp Neurol. 2011 Jun;70(6):470-80
references: 21572336
references: J Virol. 2001 Jul;75(13):6115-20
references: 11390613
references: Biomed Res Int. 2013;2013:589048
references: 24083230
references: EMBO J. 2002 May 1;21(9):2076-86
references: 11980704
references: J Comp Neurol. 2003 Jul 21;462(2):223-40
references: 12794745
references: Glia. 2002 Nov;40(2):232-9
references: 12379910
references: Lab Invest. 1988 Jan;58(1):31-6
references: 2826881
references: Microsc Res Tech. 2001 Jul 1;54(1):2-9
references: 11526953
references: Lancet Neurol. 2005 Mar;4(3):195-202
references: 15721830
references: Ann Neurol. 2000 Jun;47(6):707-17
references: 10852536
references: Neuron. 2006 Feb 16;49(4):489-502
references: 16476660
references: J Virol. 2008 Jun;82(11):5519-26
references: 18385249
references: N Engl J Med. 1973 May 24;288(21):1103-10
references: 4348989
references: Annu Rev Neurosci. 2008;31:247-69
references: 18558855
references: Nat Immunol. 2002 Oct;3(10):940-3
references: 12244309
references: J Neurosci. 2009 Aug 19;29(33):10272-80
references: 19692601
references: J Virol. 2005 Sep;79(18):11801-12
references: 16140757
references: J Neurovirol. 2002 Oct;8(5):381-91
references: 12402164
references: Brain Res Rev. 2007 Feb;53(2):344-54
references: 17188751
references: J Neurol. 2008 Dec;255 Suppl 6:7-14
references: 19300954
references: Neurology. 1984 May;34(5):597-603
references: 6324031
references: J Innate Immun. 2010;2(3):204-15
references: 20375558
references: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15983-8
references: 14668448
references: PLoS One. 2007 Dec 26;2(12):e1331
references: 18159229
references: Front Immunol. 2012 May 07;3:89
references: 22566968
references: J Virol. 1993 Jan;67(1):1-8
references: 8380065
references: Neuroscience. 1996 Sep;74(1):1-5
references: 8843071
references: Springer Semin Immunopathol. 2002;24(2):105-25
references: 12503060
references: Science. 1985 Nov 29;230(4729):1043-5
references: 2414848
references: J Virol. 2003 Mar;77(6):3799-808
references: 12610154
references: J Neuroimmunol. 1981 Mar;1(1):81-92
references: 6276437
references: APMIS. 2011 Jun;119(6):336-46
references: 21569091
references: Trends Mol Med. 2001 Mar;7(3):115-21
references: 11286782
references: Exp Neurol. 1998 Jul;152(1):74-87
references: 9682014
references: N Engl J Med. 2000 Aug 3;343(5):338-44
references: 10922424
references: J Virol. 1997 Feb;71(2):1688-91
references: 8995701