title: Oncologic outcome with use of sodium hyaluronate-carboxymethylcellulose barrier in gastric cancer.
abstract: Hyaluronan is a component of an anti-adhesive barrier and has been implicated in tumor growth and metastasis. We aimed to determine whether this anti-adhesive barrier was associated with rates of postoperative complications and duration of survival in patients with gastric cancer. We identified 415 consecutive patients with gastric cancer who underwent gastrectomy. Information about patients' demographics, medical history, surgical procedures, postoperative complications, disease stage, histology, and survival was collected from medical records. One hundred and ninety-six patients received intraoperative placement of an anti-adhesive barrier composed of hyaluronan-carboxymethylcellulose (HA-CMC) (HA-CMC group), and 219 did not (control group). The incidence of postoperative complications was significantly increased in the control group (22.8%) compared with the HA-CMC group (13.3%). However, there was no significant difference in overall survival between the HA-CMC and control groups. Our study suggests that the anti-adhesive barrier does not affect oncologic outcome, nor does it increase postoperative complications in patients undergoing surgery for gastric cancer.
authors: 1 Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan.
authors: Yasuhiko
authors: Y
authors: Mohri
authors: Koji
authors: K
authors: Tanaka
authors: Keiichi
authors: K
authors: Uchida
authors: Masaki
authors: M
authors: Ohi
authors: Mikihiro
authors: M
authors: Inoue
authors: Toshimitsu
authors: T
authors: Araki
authors: Yasuhiro
authors: Y
authors: Inoue
authors: Masato
authors: M
authors: Kusunoki
mesh_terms: D000368:Aged; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000517:prevention & control*; D012042:Registries; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis
chemical_list: D008567:Membranes, Artificial; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium
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