title: The babkin reflex in infants: clinical significance and neural mechanism.
abstract: BACKGROUND
  There have been very few studies concerning the Babkin reflex-opening of the mouth and flexion of the arms in response to stimulation of the palms. We attempted to clarify the clinical significance and neural mechanism of the reflex through systematic review.
  
  
  METHODS
  Searches were conducted on Medline, Embase, and Google Scholar from their inception through August 2012.
  
  
  RESULTS
  In normal term infants, the Babkin reflex can be elicited from the time of birth, becomes increasingly suppressed with age, and disappears in the great majority by the end of the fifth month of age. A marked response in the fourth or fifth month of age and persistence of the reflex beyond the fifth month of age are generally regarded as abnormal. On the other hand, because there are some normal infants showing no response during the neonatal period or early infancy, the absence of the response during these periods is not necessarily an abnormal finding.
  
  
  CONCLUSIONS
  Infants with these abnormal findings should be carefully observed for the appearance of neurological abnormalities including cerebral palsy and mental retardation. It is most likely that the Babkin reflex is mediated by the reticular formation of the brainstem, which receives inputs from the nonprimary motor cortices. On the basis of the hand-mouth reflex, more adaptive movement develops as control of the nonprimary motor cortices over the reflex mechanism in the reticular formation increases. Soon it evolves into the voluntary eye-hand-mouth coordination necessary for food intake as the control of the prefrontal cortex over the nonprimary motor cortices becomes predominant.
authors: Department of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan. jqfkk025@yahoo.co.jp
authors: Yasuyuki
authors: Y
authors: Futagi
authors: Keiko
authors: K
authors: Yanagihara
authors: Yukiko
authors: Y
authors: Mogami
authors: Tae
authors: T
authors: Ikeda
authors: Yasuhiro
authors: Y
authors: Suzuki
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D009434:Neural Pathways / Q000502:physiology; D001405:Reflex, Babinski / Q000473:pathology* / Q000503:physiopathology