title: Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae.
abstract: We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.
authors: Department of Medicine.
authors: Masayuki
authors: M
authors: Nigo
authors: Catalina Salinas
authors: CS
authors: Cevallos
authors: Krystina
authors: K
authors: Woods
authors: Vicente Maco
authors: VM
authors: Flores
authors: Gweneth
authors: G
authors: Francis
authors: David C
authors: DC
authors: Perlman
authors: Manuel
authors: M
authors: Revuelta
authors: Donna
authors: D
authors: Mildvan
authors: Mary
authors: M
authors: Waldron
authors: Tessa
authors: T
authors: Gomez
authors: Sanjana
authors: S
authors: Koshy
authors: Tomasz
authors: T
authors: Jodlowski
authors: William
authors: W
authors: Riley
authors: Jörg J
authors: JJ
authors: Ruhe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development; D016015:Logistic Models; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078304:Tigecycline; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
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