title: Copeptin as a novel biomarker in nocturnal enuresis.
abstract: OBJECTIVE
  To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE).
  
  
  METHODS
  Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations.
  
  
  RESULTS
  Copeptin levels were significantly lower in patient group (3.74 ± 1.44 pg/mL) than the control group (16.57 ± 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 ± 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 ± 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week.
  
  
  CONCLUSIONS
  This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE.
authors: Department of Pediatrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey. Electronic address: bnalbantoglu@nku.edu.tr.
authors: Burçin
authors: B
authors: Nalbantoğlu
authors: Cenk Murat
authors: CM
authors: Yazıcı
authors: Ayşin
authors: A
authors: Nalbantoğlu
authors: Savaş
authors: S
authors: Güzel
authors: Birol
authors: B
authors: Topçu
authors: Eda Çelik
authors: EÇ
authors: Güzel
authors: M Metin
authors: MM
authors: Donma
authors: Burcu
authors: B
authors: Özdilek
authors: Nuriye Ece
authors: NE
authors: Mintaş
mesh_terms: D000293:Adolescent; D001127:Arginine Vasopressin / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000097:blood*; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D001127:Arginine Vasopressin