title: Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.
abstract: Ebola virus (EBOV) remains one of the most lethal transmissible infections and is responsible for high fatality rates and substantial morbidity during sporadic outbreaks. With increasing human incursions into endemic regions and the reported possibility of airborne transmission, EBOV is a high-priority public health threat for which no preventive or therapeutic options are currently available. Recent studies have demonstrated that cocktails of monoclonal antibodies are effective at preventing morbidity and mortality in nonhuman primates (NHPs) when administered as a post-exposure prophylactic within 1 or 2 days of challenge. To test whether one of these cocktails (MB-003) demonstrates efficacy as a therapeutic (after the onset of symptoms), we challenged NHPs with EBOV and initiated treatment upon confirmation of infection according to a diagnostic protocol for U.S. Food and Drug Administration Emergency Use Authorization and observation of a documented fever. Of the treated animals, 43% survived challenge, whereas both the controls and all historical controls with the same challenge stock succumbed to infection. These results represent successful therapy of EBOV infection in NHPs.
authors: Division of Virology, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.
authors: James
authors: J
authors: Pettitt
authors: Larry
authors: L
authors: Zeitlin
authors: Do H
authors: DH
authors: Kim
authors: Cara
authors: C
authors: Working
authors: Joshua C
authors: JC
authors: Johnson
authors: Ognian
authors: O
authors: Bohorov
authors: Barry
authors: B
authors: Bratcher
authors: Ernie
authors: E
authors: Hiatt
authors: Steven D
authors: SD
authors: Hume
authors: Ashley K
authors: AK
authors: Johnson
authors: Josh
authors: J
authors: Morton
authors: Michael H
authors: MH
authors: Pauly
authors: Kevin J
authors: KJ
authors: Whaley
authors: Michael F
authors: MF
authors: Ingram
authors: Ashley
authors: A
authors: Zovanyi
authors: Megan
authors: M
authors: Heinrich
authors: Ashley
authors: A
authors: Piper
authors: Justine
authors: J
authors: Zelko
authors: Gene G
authors: GG
authors: Olinger
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D046129:Ebola Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D029043:Ebolavirus / Q000235:genetics / Q000276:immunology*; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D046549:Plantibodies / Q000008:administration & dosage / Q000627:therapeutic use; D056990:Post-Exposure Prophylaxis / Q000379:methods; D057170:Translational Research, Biomedical; D014766:Viremia / Q000276:immunology / Q000517:prevention & control / Q000628:therapy
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000914:Antibodies, Viral; D046129:Ebola Vaccines; D046549:Plantibodies