title: Acyl glycosides with rare β-D-apiofuranosyl-β-D-glucopyranosyl-β-D-apiofuranosyl from Erycibe hainanesis.
abstract: Three new acyl glycosides with rare β-D-apiofuranosyl-(1→2)-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranosyl moieties, 2-O-[2,6-O-bis(5-O-syringoyl-β-D-apiofuranosyl)-β-D-glucopyranosyl]-isopropyl alcohol (1), 1-O-[2,6-O-bis(5-O-syringoyl-β-D-apiofuranosyl)-β-D-glucopyranosyl]-isoamyl alcohol (2), and 1-O-[2,6-O-bis(5-O-vanilloyl-β-D-apiofuranosyl)-β-D-glucopyranosyl]-3,4,5-trimethoxyphenol (3) were obtained from Erycibe hainanesis. Their structures were determined by UV, IR, HRESIMS, (1)D and (2)D NMR data, and by chemical methods. Compounds 1-3 were evaluated against D-galactosamine induced toxicity in WB-F344 rat hepatic epithelial stem-like cells, and compounds 1 and 3 showed moderate hepatoprotective activities.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China.
authors: Zi-ming
authors: ZM
authors: Feng
authors: Shuang
authors: S
authors: Song
authors: Jun
authors: J
authors: He
authors: Ya-nan
authors: YN
authors: Yang
authors: Jian-shuang
authors: JS
authors: Jiang
authors: Pei-cheng
authors: PC
authors: Zhang
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002460:Cell Line; D019610:Cytoprotection / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D005688:Galactosamine / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D022781:Hepatocytes / Q000166:cytology; D008969:Molecular Sequence Data; D051381:Rats; D013234:Stem Cells / Q000166:cytology; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D006027:Glycosides; D005688:Galactosamine
keywords: Acyl glycoside; Convolvulaceae; Erycibe hainanesis; Hepatoprotective activity; β-d-Apiofuranosyl-β-d-glucopyranosyl-β-d-apiofuranosyl