title: Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review.
abstract: A 41-year-old male had suffered from gradual hearing loss in his right ear for 2 years. Head computed tomography and magnetic resonance imaging scans showed a neoplasm in the cerebellopontine angle region, which was confirmed by the diagnosis of acoustic neurilemmoma by pathological findings after surgery. Following surgery, he routinely received valproic acid (VPA) to prevent seizures. However, the patient presented with hypofibrinogenemia and cerebral hemorrhage after taking VPA for 12 days. The hypofibrinogenemia recurred when VPA was re-administered. After withdrawal of VPA, his fibrinogen concentration rose to normal within several days. As far as we are aware, this is the first case of cerebral hemorrhage due to VPA to have been reported. Herein, as well as reporting on this case, a mini review of the relevant literature is also presented.
authors: Department of Hematology, 100th Hospital of People's Liberation Army, Suzhou, People's Republic of China.
authors: Hai-Fei
authors: HF
authors: Chen
authors: Li-Ping
authors: LP
authors: Xu
authors: Zhi-Yong
authors: ZY
authors: Luo
authors: Zi-Qiang
authors: ZQ
authors: Yu
authors: Zheng-Yang
authors: ZY
authors: Li
authors: Qing-Ya
authors: QY
authors: Cui
authors: Long-Mei
authors: LM
authors: Qin
authors: Yong-Ya
authors: YY
authors: Ren
authors: Hong-Shi
authors: HS
authors: Shen
authors: Jie-Qing
authors: JQ
authors: Tang
authors: Ling-Juan
authors: LJ
authors: Jin
authors: Jing-Jing
authors: JJ
authors: Zhu
authors: Jing
authors: J
authors: Wang
authors: Ke-Yuan
authors: KY
authors: Wang
authors: Tian-Qin
authors: TQ
authors: Wu
authors: Zhao-Yue
authors: ZY
authors: Wang
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000139:chemically induced*; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012640:Seizures / Q000517:prevention & control; D013997:Time Factors; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid
keywords: cerebellopontine angle; cerebral hemorrhage; hypofibrinogenemia; neoplasm; side effect
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