title: Anti-diarrheal activity and toxicity of Learng Pid Samud recipe.
abstract: Learng Pid Samud (LPS) recipe is a traditional remedy in Thai folk medicine to ease the common diarrhea. The anti-diarrheal potential of LPS recipe was herein examined in vitro using a guinea-pig ileum model. The LPS exerted an inhibitory effect on acetylcholine-induced smooth muscle contraction in the guinea pig ileum. Significantly, not only did the LPS reduce the total amount of feces in the induced diarrhea rats, but also the intestinal transit in the charcoal meal test. A single oral administration with the recipe at 5,000 mg/kg did not cause acute toxicity and the daily oral administration (1,000, 2,000 and 4,000 mg/kg) for 90 days in rats did not produce any toxic signs and symptoms. In conclusion, the Learng Pid Samud recipe remedy is evidently safe and effective for the anti-diarrheal treatment which supports its therapeutic uses in the alternative medicine.
authors: Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand. seewaboon@gmail.com
authors: Seewaboon
authors: S
authors: Sireeratawong
authors: Parirat
authors: P
authors: Khonsung
authors: Urarat
authors: U
authors: Nanna
authors: Supaporn
authors: S
authors: Vannasiri
authors: Nirush
authors: N
authors: Lertprasertsuke
authors: Tipaya
authors: T
authors: Singhalak
authors: Noppamas
authors: N
authors: Soonthornchareonnon
authors: Kanjana
authors: K
authors: Jaijoy
mesh_terms: D000818:Animals; D002606:Charcoal / Q000378:metabolism; D003672:Defecation / Q000187:drug effects; D003967:Diarrhea / Q000188:drug therapy*; D004195:Disease Models, Animal; D005243:Feces; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008519:Medicine, Traditional; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013785:Thailand
chemical_list: D010936:Plant Extracts; D002606:Charcoal
keywords: Acute toxicity; Anti-diarrheal activity; Chronic toxicity; Learng Pid Samud
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