title: The anti-inflammatory and anti-nociceptive activities of Patrinia villosa and its mechanism on the proinflammatory cytokines of rats with pelvic inflammation.
abstract: This study explores the anti-inflammatory and anti-nociceptive activities of Patrinia villosa, a Chinese medicinal plant, and to explore its effects on the proinflammatory cytokines of the rats with pelvic inflammation model. The animals were randomly divided into Patrinia villosa group (PV group), dexamethasone group (DEX group), and model-control group (CON group) to perform an ear edema test, a carrageenin-induced paw edema test, a cotton pellet-induced granuloma formation test, and an acetic acid-induced writhing test. The model rats with pelvic inflammation were established, and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) in each group was detected with the Enzyme-Linked ImmunoSorbent Assay (ELISA). The results of the ear edema test, carrageenin-induced paw edema test, cotton pellet-induced granuloma formation test, and acetic acid-induced writhing test all showed that Patrinia villosa had strong anti-inflammatory and anti-nociceptive effects. In the experiment using model rats with pelvic inflammation, we found that the serum levels of IL-6, IL-8 and TNF-α in PV and DEX group were all significantly lower than those of the CON group, and the serum levels of IL-6 and IL-8 in PV group were significantly lower than those of the DEX group. Patrinia villosa, with its strong anti-inflammatory and anti-nociceptive activities, can be used to treat pelvic inflammation and to relieve the associated pain.
authors: Department of Gynecology, The First Affiliated Hospital, Medical College of Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, PR China.
authors: Yan
authors: Y
authors: Zheng
authors: Yue
authors: Y
authors: Jin
authors: Hai-Bin
authors: HB
authors: Zhu
authors: Shao-Ting
authors: ST
authors: Xu
authors: Ya-Xian
authors: YX
authors: Xia
authors: Yue
authors: Y
authors: Huang
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy; D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D004487:Edema / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D051379:Mice; D008813:Mice, Inbred ICR; D032405:Patrinia; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D002351:Carrageenan; D019342:Acetic Acid
keywords: Patrinia villosa; anti-inflammatory; anti-nociceptive; pelvic inflammation
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