title: Erectile dysfunction and asymptomatic coronary artery disease: frequently detected by computed tomography coronary angiography but not by exercise electrocardiography.
abstract: OBJECTIVE
  Erectile dysfunction (ED) and vascular disease, in particular coronary artery disease (CAD), have the common denominator of endothelial dysfunction. ED frequently precedes a CAD event by between 2 and 5 years (average 3 years). ED also predicts an acute coronary syndrome as well as increased mortality, suggesting the rupture of an asymptomatic coronary plaque. This study compares multi-detector cardiac computed tomography (MDCT) with maximal treadmill exercising in men with ED and no coronary symptoms as a means of detecting coronary lesions.
  
  
  METHODS
  Sixty-five men with organic ED and no cardiac symptoms were prospectively screened for CAD. All underwent maximal exercise testing and MDCT in the same 7-day period. The Sexual Health Inventory for Men questionnaire established the presence of ED.
  
  
  RESULTS
  The exercise ECG was borderline abnormal in three men and normal in 62. CT calcium was present in 53 (score 5-1671) and non-calcified plaque in seven. The MDCT angiogram was normal in only 5 (3.25%).
  
  
  CONCLUSIONS
  Erectile dysfunction may predict CAD in the absence of cardiac symptoms. MDCT detects subclinical plaque which may be vulnerable to rupture and which is not flow limiting enough to influence the exercise ECG. The window of 2-5 years between ED and a CAD event offers an opportunity for aggressive risk factor reduction. ED should be a routine question in any risk calculator.
authors: London Bridge Hospital, London, UK; Guy's and St Thomas' Hospitals NHS Trust, London, UK.
authors: G
authors: G
authors: Jackson
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis; D004562:Electrocardiography; D007172:Erectile Dysfunction / Q000150:complications*; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D058226:Plaque, Atherosclerotic / Q000175:diagnosis; D011446:Prospective Studies