title: A laser-induced mouse model of chronic ocular hypertension to characterize visual defects.
abstract: Glaucoma, frequently associated with elevated intraocular pressure (IOP), is one of the leading causes of blindness. We sought to establish a mouse model of ocular hypertension to mimic human high-tension glaucoma. Here laser illumination is applied to the corneal limbus to photocoagulate the aqueous outflow, inducing angle closure. The changes of IOP are monitored using a rebound tonometer before and after the laser treatment. An optomotor behavioral test is used to measure corresponding changes in visual capacity. The representative result from one mouse which developed sustained IOP elevation after laser illumination is shown. A decreased visual acuity and contrast sensitivity is observed in this ocular hypertensive mouse. Together, our study introduces a valuable model system to investigate neuronal degeneration and the underlying molecular mechanisms in glaucomatous mice.
authors: Department of Ophthalmology, Northwestern University, USA.
authors: Liang
authors: L
authors: Feng
authors: Hui
authors: H
authors: Chen
authors: Genn
authors: G
authors: Suyeoka
authors: Xiaorong
authors: X
authors: Liu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D017075:Laser Coagulation / Q000379:methods; D007834:Lasers; D051379:Mice; D009798:Ocular Hypertension
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