title: Recurrent connections form a phase-locking neuronal tuner for frequency-dependent selective communication.
abstract: The brain requires task-dependent interregional coherence of information flow in the anatomically connected neural network. However, it is still unclear how a neuronal group can flexibly select its communication target. In this study, we revealed a hidden routing mechanism on the basis of recurrent connections. Our simulation results based on the spike response model show that recurrent connections between excitatory and inhibitory neurons modulate the resonant frequency of a local neuronal group, and that this modulation enables a neuronal group to receive selective information by filtering a preferred frequency component. We also found that the recurrent connection facilitates the successful routing of any necessary information flow between neuronal groups through frequency-dependent resonance of synchronized oscillations. Taken together, these results suggest that recurrent connections act as a phase-locking neuronal tuner which determines the resonant frequency of a local group and thereby controls the preferential routing of incoming signals.
authors: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea.
authors: Dongkwan
authors: D
authors: Shin
authors: Kwang-Hyun
authors: KH
authors: Cho
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
references: Trends Cogn Sci. 2005 Oct;9(10):474-80
references: 16150631
references: Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11073-8
references: 17576922
references: J Neurosci. 2008 Feb 20;28(8):1871-81
references: 18287504
references: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7580-5
references: 20368447
references: J Neurosci. 1998 Jan 1;18(1):388-98
references: 9412515
references: Proc Natl Acad Sci U S A. 1989 Mar;86(5):1698-702
references: 2922407
references: Science. 2009 May 29;324(5931):1207-10
references: 19478185
references: Neural Comput. 2003 Mar;15(3):509-38
references: 12620157
references: Neural Comput. 1999 Oct 1;11(7):1621-71
references: 10490941
references: Annu Rev Neurosci. 1995;18:555-86
references: 7605074
references: Trends Cogn Sci. 2007 Jul;11(7):267-9
references: 17548233
references: Neuroscience. 2009 Sep 1;162(3):805-15
references: 19409229
references: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20517-22
references: 19074268
references: Science. 2005 Apr 1;308(5718):111-3
references: 15802603
references: J Neurophysiol. 1998 Mar;79(3):1592-6
references: 9497437
references: J Neurophysiol. 1998 Nov;80(5):2521-37
references: 9819260
references: Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):227-40
references: 4110392
references: Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14495-500
references: 17726109
references: Nat Rev Neurosci. 2001 Oct;2(10):704-16
references: 11584308
references: J Neurosci. 2008 May 14;28(20):5268-80
references: 18480283
references: Nature. 1996 Feb 22;379(6567):728-32
references: 8602219
references: Hippocampus. 2000;10(2):187-97
references: 10791841
references: Neuron. 2004 Apr 22;42(2):253-68
references: 15091341
references: Science. 2008 Jul 4;321(5885):126-9
references: 18599789
references: Nature. 1999 Dec 2;402(6761):529-33
references: 10591212
references: Front Syst Neurosci. 2009 Apr 10;3:4
references: 19404487
references: Biol Cybern. 2008 Nov;99(4-5):403-16
references: 18985377
references: Neuron. 1999 Sep;24(1):49-65, 111-25
references: 10677026
references: Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3228-33
references: 20133762
references: Neuron. 2008 Nov 26;60(4):709-19
references: 19038226
references: Phys Rev Lett. 2000 Apr 24;84(17):4006-9
references: 11019261
references: Phys Rev Lett. 1995 Nov 27;75(22):4071-4074
references: 10059807
references: J Neurosci. 1995 Jan;15(1 Pt 1):47-60
references: 7823151
references: Neuron. 2010 Jul 29;67(2):308-20
references: 20670837
references: Cereb Cortex. 1997 Sep;7(6):571-82
references: 9276181
references: Vision Res. 1967 Mar;7(3):215-29
references: 5613293
references: Int J Psychophysiol. 2000 Dec 1;38(3):315-36
references: 11102670
references: Biophys J. 1972 Jan;12(1):1-24
references: 4332108
references: J Neurosci. 2004 Dec 15;24(50):11356-67
references: 15601942
references: Hippocampus. 1993 Jul;3(3):317-30
references: 8353611
references: Nature. 1997 Jan 9;385(6612):157-61
references: 8990118
references: Science. 2008 Jul 4;321(5885):53-7
references: 18599766
references: Nat Rev Neurosci. 2001 Apr;2(4):229-39
references: 11283746
references: Science. 2007 Jun 15;316(5831):1609-12
references: 17569862
references: Neuron. 2011 Jan 27;69(2):387-96
references: 21262474
references: PLoS Comput Biol. 2008 Dec;4(12):e1000239
references: 19079571
references: Science. 2006 Sep 15;313(5793):1626-8
references: 16973878
references: Science. 2007 Jun 15;316(5831):1612-5
references: 17569863
references: Trends Cogn Sci. 2010 Nov;14(11):506-15
references: 20932795
references: Nat Neurosci. 2009 Apr;12(4):483-91
references: 19305402
references: Schizophr Bull. 2008 Sep;34(5):974-80
references: 18559405
references: Nature. 2009 Nov 19;462(7271):353-7
references: 19924214
references: Nat Neurosci. 2008 May;11(5):587-94
references: 18425124
references: Biol Cybern. 1986;54(1):29-40
references: 3719028
references: J Cell Sci. 2010 Feb 15;123(Pt 4):537-43
references: 20103537
references: Nat Rev Neurosci. 2001 Aug;2(8):539-50
references: 11483997