title: Asteriscane-type sesquiterpenoids from the soft coral Sinularia capillosa.
abstract: Chemical examination of the soft coral Sinularia capillosa collected from the South China Sea resulted in the isolation of 14 new asteriscane-type sesquiterpenoids, namely, capillosananes A-N (1-14), four new seco-asteriscanes, capillosananes O-R (15-18), and (-)-sinularone A and sinularone A. Their structures were determined on the basis of extensive spectroscopic analyses, while the absolute configurations were determined by CD and ECD calculation, Mosher's method, and chemical conversion. This is the first report of asteriscane-type sesquiterpenoids from soft corals, and capillosananes Q (17) and R (18) represent new seco-asteriscane skeletons. Capillosanane A exhibited potent antifouling activity against Balanus amphitrite, with an IC₅₀ value of 9.70 μM, while capillosananes B and I and (-)-sinularone A inhibited inflammation-related TNF-α in vitro.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, People's Republic of China.
authors: Dawei
authors: D
authors: Chen
authors: Wei
authors: W
authors: Chen
authors: Dong
authors: D
authors: Liu
authors: Leen
authors: L
authors: van Ofwegen
authors: Peter
authors: P
authors: Proksch
authors: Wenhan
authors: W
authors: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010933:Plankton / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C584991:capillosanane Q