title: Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys.
abstract: BACKGROUND
  Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enables distinct disease-associated mechanisms to be identified.
  
  
  RESULTS
  Here we report the first longitudinal study of transgenic monkeys with genomic integration of various lengths of the human HTT gene and a range of polyQ repeats. With this unique group of transgenic HD nonhuman primates (HD monkeys), we profiled over 47,000 transcripts from peripheral blood collected over a 2 year timespan from HD monkeys and age-matched wild-type control monkeys.
  
  
  CONCLUSIONS
  Messenger RNAs with expression patterns which diverged with disease progression in the HD monkeys considerably facilitated our search for transcripts with diagnostic or therapeutic potential in the blood of human HD patients, opening up a new avenue for clinical investigation.
authors: Jannet
authors: J
authors: Kocerha
authors: Yuhong
authors: Y
authors: Liu
authors: David
authors: D
authors: Willoughby
authors: Kumaravel
authors: K
authors: Chidamparam
authors: Joseph
authors: J
authors: Benito
authors: Kate
authors: K
authors: Nelson
authors: Yan
authors: Y
authors: Xu
authors: Tim
authors: T
authors: Chi
authors: Heidi
authors: H
authors: Engelhardt
authors: Sean
authors: S
authors: Moran
authors: Shang-Hsun
authors: SH
authors: Yang
authors: Shi-Hua
authors: SH
authors: Li
authors: Xiao-Jiang
authors: XJ
authors: Li
authors: Katherine
authors: K
authors: Larkin
authors: Adam
authors: A
authors: Neumann
authors: Heather
authors: H
authors: Banta
authors: Jin Jing
authors: JJ
authors: Yang
authors: Anthony W S
authors: AW
authors: Chan
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000097:blood / Q000235:genetics*; D008137:Longitudinal Studies; D008253:Macaca mulatta; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D059467:Transcriptome
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger
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