title: Sustained static stress-induced chondrocyte apoptosis in the rat   cervical vertebral growth plate and its signal transduction   mechanisms.
abstract: Apoptosis of the vertebral growth plate chondrocytes plays an important role in the pathogenesis of intervertebral disk degeneration. In this paper, we have successfully established an experimental model induced by static stress and provided a useful method to study the mechanisms of chondrocyte apoptosis.A sustained static load of C0.2 MPa over at least 12 h was observed to induce chondrocyte apoptosis, up-regulation of bax and caspase-3 expression, and down-regulation of bcl-2 expression.
authors: Ming
authors: M
authors: Zhang
authors: Tiansheng
authors: T
authors: Zheng
authors: Min
authors: M
authors: Zong
authors: Dechao
authors: D
authors: Kong
authors: Xiang
authors: X
authors: Li
authors: Cheng
authors: C
authors: Xue
authors: Peng
authors: P
authors: Fu
authors: Jiahu
authors: J
authors: Fang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015153:Blotting, Western; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D002574:Cervical Vertebrae; D019902:Chondrocytes / Q000502:physiology*; D006132:Growth Plate / Q000502:physiology*; D020287:In Situ Nick-End Labeling; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology