title: Copper-mediated direct C2-cyanation of indoles using acetonitrile as the cyanide source.
abstract: A copper-mediated C2-cyanation of indoles using cheap and commercially available acetonitrile as the "nonmetallic" cyanide source was achieved through sequential C-C and C-H bond cleavages. The installation of a removable pyrimidyl group on the indole nitrogen atom is the key for this C2 selectivity. This approach provides a novel and alternative route leading to indole-2-carbonitrile.
authors: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.
authors: Changduo
authors: C
authors: Pan
authors: Hongming
authors: H
authors: Jin
authors: Pan
authors: P
authors: Xu
authors: Xu
authors: X
authors: Liu
authors: Yixiang
authors: Y
authors: Cheng
authors: Chengjian
authors: C
authors: Zhu
mesh_terms: D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D007211:Indoles; D009570:Nitriles; D009942:Organometallic Compounds; D003300:Copper