title: Long-term recurrence-free survival after metachronous surgery of the stomach and liver for gastric adenocarcinoma and multiple, synchronous liver metastases: a case report and review of literature.
abstract: This report describes a 58-year-old woman with gastric adenocarcinoma and liver metastases, who survives for more than 18 years after diagnosis. At diagnosis and first surgery, a moderately differentiated gastric adenocarcinoma with subserosal invasion was detected, along with 2 regional lymph node metastases and 2 liver metastases. She underwent gastrectomy and regional lymph node dissection but did not undergo liver operation then. After gastrectomy, she received adjuvant chemotherapy for 1 month but discontinued it due to severe diarrhea. Another metastasis in another area of the liver was detected, for which she underwent excision of the right lobe of the liver (subsegments 5, 6, and 7) about 30 months later. No signs of recurrence have been detected for 18 years (as of March 2012). This patient represents a rare case of long-term survival of gastric adenocarcinoma without recurrence after surgical treatment, despite multiple, synchronous, liver and regional lymph node metastases.
authors: Department of Gastroenterological Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan.
authors: Yoshito
authors: Y
authors: Kiyasu
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000601:surgery*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D014408:Biomarkers, Tumor
references: Gastric Cancer. 2011 Oct;14(4):301-16
references: 21894577
references: Surgery. 2003 May;133(5):507-11
references: 12773978
references: Surg Today. 2002;32(7):587-93
references: 12111514
references: Hepatogastroenterology. 2001 Mar-Apr;48(38):368-71
references: 11379310
references: Am J Surg. 2001 Mar;181(3):279-83
references: 11376587
references: Surg Today. 2001;31(2):159-62
references: 11291712
references: Hepatogastroenterology. 1995 Sep-Oct;42(5):666-71
references: 8751232
references: Br J Surg. 1994 Aug;81(8):1175-8
references: 7953354
references: Hepatogastroenterology. 2003 Sep-Oct;50(53):1560-3
references: 14571786