title: Extracellular lipid metabolism influences the survival of ovarian cancer cells.
abstract: Lysophosphatidic acid (LPA) is an extracellular lipid mediator consisting of a fatty acid and a phosphate group linked to the glycerol backbone. Here, we show that 1-oleoyl- and 1-palmitoyl-LPA, but not 1-stearoyl- or alkyl-LPA, enhance HNOA ovarian cancer cell survival. Other lysophospholipids with oleic or lauric acid, but not stearic acid, also induce the survival effects. HNOA cells have the lipase activities that cleave LPA to generate fatty acid. Oleic acid stimulates HNOA cell survival via increased glucose utilization. Our findings suggest that extracellular lysolipid metabolism might play an important role in HNOA cell growth.
authors: Division of Molecular Neurobiology, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan.
authors: Shohei
authors: S
authors: Kuwata
authors: Kei
authors: K
authors: Ohkubo
authors: Shun
authors: S
authors: Kumamoto
authors: Naoto
authors: N
authors: Yamaguchi
authors: Naoki
authors: N
authors: Izuka
authors: Kaeko
authors: K
authors: Murota
authors: Toshifumi
authors: T
authors: Tsujiuchi
authors: Masao
authors: M
authors: Iwamori
authors: Nobuyuki
authors: N
authors: Fukushima
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D050356:Lipid Metabolism; D008246:Lysophospholipids / Q000235:genetics / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D010053:Ovary / Q000378:metabolism* / Q000473:pathology*
chemical_list: D005227:Fatty Acids; D008246:Lysophospholipids; C026671:1-palmitoyl-lysophosphatidic acid; C032881:lysophosphatidic acid
keywords: Cell survival; Fatty acid; Lysophosphatidic acid; Lysophospholipase; Ovarian cancer cell