title: Genotoxic effects of bisphenol A on somatic cells of female mice, alone and in combination with X-rays.
abstract: Bisphenol A (BPA), a monomer used in the manufacture of epoxy, polycarbonate, and polystyrene resins, is a xenoestrogen present in many consumer products. We investigated the effects of 2-week exposure to BPA, either alone or in combination with X-rays, on the induction of DNA damage in somatic cells of female mice in vivo. The micronucleus and alkaline comet assays were used to evaluate genotoxicity. BPA induced DNA strand breaks in lung cells but not in bone marrow lymphocytes, liver, kidney, or spleen cells. Induction of micronuclei was observed only in polychromatic reticulocytes of peripheral blood. Levels of damage following combination exposure to ionizing radiation plus BPA depended on tissue, assay, and time.
authors: National Institute of Public Health - National Institute of Hygiene, Department of Radiation Hygiene and Radiobiology, 24 Chocimska Street, 00-791 Warsaw, Poland.
authors: Aneta
authors: A
authors: Gajowik
authors: Joanna
authors: J
authors: Radzikowska
authors: Małgorzata M
authors: MM
authors: Dobrzyńska
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000494:pharmacology; D000818:Animals; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D020552:Comet Assay; D053960:DNA Breaks / Q000187:drug effects* / Q000528:radiation effects*; D005260:Female; D008214:Lymphocytes / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D059351:Organ Sparing Treatments; D010636:Phenols / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors; D014965:X-Rays; D000098826:Bisphenol A Compounds
chemical_list: D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Comet assay; Micronucleus; X-ray