title: Differences and associations of metabolic and vitamin D status among patients with and without sub-clinical hypothyroid dysfunction.
abstract: BACKGROUND
  Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of the population suffer from hypovitaminosis D (<50 nmol/l). In this cross-sectional case-control study, we described the differences and associations in the metabolic patterns of adult Saudis with and without hypothyroid dysfunction in relation to their vitamin D status, PTH, calcium and lipid profile.
  
  
  METHODS
  A total of 94 consenting adult Saudis [52 controls (without subclinical hypothyroidism), 42 cases (previously diagnosed subjects)] were included in this cross-sectional study. Anthropometrics were obtained and fasting blood samples were taken for ascertaining lipid and thyroid profile, as well as measuring PTH, 25(OH) vitamin D and calcium.
  
  
  RESULTS
  Cases had a significantly higher body mass index than the controls (p < 0.001). Circulating triglycerides was also significantly higher in cases than the controls (p = 0.001). A significant positive association between HDL-cholesterol and PTH (R = 0.56; p = 0.001), as well as a negative and modestly significant negative association between LDL-cholesterol and PTH (R = - 20.0; p = 0.04) were observed. FT3 was inversely associated with circulating 25 (OH) vitamin D (R = -0.25; p = 0.01).
  
  
  CONCLUSIONS
  Patients with hypothyroid dysfunction possess several cardiometabolic risk factors that include obesity and dyslipidemia. The association between PTH and cholesterol levels as well as the inverse association between vitamin D status and FT3 needs to be reassessed prospectively on a larger scale to confirm these findings.
authors: Biochemistry Department, Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi Arabia. aldaghri2011@gmail.com.
authors: Naji J
authors: NJ
authors: Aljohani
authors: Nasser M
authors: NM
authors: Al-Daghri
authors: Omar S
authors: OS
authors: Al-Attas
authors: Majed S
authors: MS
authors: Alokail
authors: Khalid M
authors: KM
authors: Alkhrafy
authors: Abdulaziz
authors: A
authors: Al-Othman
authors: Sobhy
authors: S
authors: Yakout
authors: Abdulaziz F
authors: AF
authors: Alkabba
authors: Ahmed S
authors: AS
authors: Al-Ghamdi
authors: Mussa
authors: M
authors: Almalki
authors: Badurudeen Mahmood
authors: BM
authors: Buhary
authors: Shaun
authors: S
authors: Sabico
references: Clin Endocrinol (Oxf). 2012 Mar;76(3):346-50
references: 21906116
references: Curr Med Res Opin. 2013 Apr;29(4):305-13
references: 23320612
references: Endocrine. 2013 Feb;43(1):3-5
references: 22926719
references: Thyroid. 2013 Jan;23(1):25-30
references: 22931506
references: Respir Med. 2011 Nov;105(11):1755-60
references: 21820299
references: Lipids Health Dis. 2012 Mar 27;11:44
references: 22448646
references: Eur J Endocrinol. 2012 Jul;167(1):43-8
references: 22518050
references: Endocrine. 2012 Dec;42(3):739-41
references: 22547366
references: Endocrinology. 2013 Feb;154(2):609-22
references: 23307792
references: Ann Endocrinol (Paris). 2011 Apr;72(2):68-73
references: 21511243
references: Endokrynol Pol. 2012;63(3):196-201
references: 22744625
references: Treat Endocrinol. 2004;3(4):233-44
references: 16026106
references: J Thyroid Res. 2011;2011:306510
references: 21687648
references: Saudi Med J. 2010 Jul;31(7):775-80
references: 20635011
references: Eur J Endocrinol. 2002 Jun;146(6):777-81
references: 12039697
references: J Clin Endocrinol Metab. 2011 Jan;96(1):168-75
references: 20980431
references: Bone. 2010 Mar;46(3):747-51
references: 19892039
references: Endocrine. 2013 Feb;43(1):230-2
references: 22983830
references: J Clin Endocrinol Metab. 2012 Aug;97(8):2724-31
references: 22730515
references: J Bone Miner Res. 2005 Mar;20(3):480-6
references: 15746993
references: Acta Diabetol. 2006 May;43(1):14-8
references: 16710644
references: Heart. 2011 Feb;97(4):315-20
references: 21193684
references: J Clin Endocrinol Metab. 1997 Apr;82(4):1118-25
references: 9100583
references: Horm Metab Res. 2013 Jan;45(1):43-6
references: 22972177
references: Ann Saudi Med. 1994 Jul;14(4):283-5
references: 17586918
references: Obesity (Silver Spring). 2013 Jan;21(1):101-6
references: 23505173