title: Synthesis and biological evaluation of novel ferrocenyl curcuminoid derivatives.
abstract: With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side chain was clearly shown to improve the biological activity of most of their corresponding organic curcuminoid analogues.
authors: Laboratoire Charles Friedel Chimie ParisTech CNRS : UMR7223 Université Paris VI - Pierre et Marie Curie 11 rue Pierre et Marie Curie 72531 Paris Cedex 05, FR.
authors: Anusch
authors: A
authors: Arezki
authors: Guy
authors: G
authors: Chabot
authors: Lionel
authors: L
authors: Quentin
authors: Daniel
authors: D
authors: Scherman
authors: Gérard
authors: G
authors: Jaouen
authors: Emilie
authors: E
authors: Brulé
keywords: B16 melanoma; NIH 3T3 cells; cancer; curcuminoid; endothelial cells; ferrocenyl
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