title: Increased expression of Trop2 correlates with poor survival in extranodal NK/T cell lymphoma, nasal type.
abstract: Human trophoblastic cell surface antigen 2 (Trop2) has been suggested to play an important role in the development of solid tumors. However, the expression of Trop2 in extranodal NK/T cell lymphoma, nasal type (ENKTL) and the relationship with the clinical characteristics of this disease remain poorly understood. In this study, one-step quantitative PCR reverse transcription-polymerase chain reaction and immunohistochemical staining with tissue sections were employed to evaluate the expression of Trop2 in ENKTL. Furthermore, the relationship between Trop2 expression and prognosis of ENKTL was investigated. Expression of Trop2 mRNA and protein was significantly higher in ENKTL tissue than in corresponding non-lymphomatous tissue (p = 0.04 and p < 0.001, respectively). Expression of Trop2 protein in ENKTL was associated with lymph node involvement and poor overall survival (p = 0.045 and p = 0.018, respectively). Kaplan-Meier analysis and the logrank test indicated that lymph node involvement (p = 0.0481), single therapy strategy (p = 0.0037), and high expression of Trop2 (p = 0.0042) are significantly correlated with poor prognosis of ENKTL patients. The data suggest that Trop2 expression reflects a more malignant phenotype and may serve as an unfavorable prognostic factor for ENKTL.
authors: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing, 210011, China.
authors: Renjie
authors: R
authors: Chen
authors: Meiping
authors: M
authors: Lu
authors: Jun
authors: J
authors: Wang
authors: Dawei
authors: D
authors: Zhang
authors: Hong
authors: H
authors: Lin
authors: Huijun
authors: H
authors: Zhu
authors: Weiming
authors: W
authors: Zhang
authors: Lin
authors: L
authors: Xiong
authors: Jun
authors: J
authors: Ma
authors: Yuan
authors: Y
authors: Mao
authors: Jin
authors: J
authors: Zhu
authors: Jiaren
authors: J
authors: Xu
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C499380:TACSTD2 protein, human
references: Nature. 2004 May 27;429(6990):457-63
references: 15164071
references: Anticancer Res. 2010 Jul;30(7):2497-503
references: 20682974
references: Lab Invest. 2004 Mar;84(3):320-31
references: 14767486
references: Am J Clin Pathol. 2012 Sep;138(3):435-47
references: 22912362
references: Mod Pathol. 2008 Feb;21(2):186-91
references: 18084248
references: Head Neck. 2013 Oct;35(10):1373-8
references: 22987366
references: Am J Clin Pathol. 2007 Oct;128(4):579-84
references: 17875508
references: Int J Cancer. 1998 May 29;76(5):671-6
references: 9610724
references: Br J Cancer. 2008 Oct 21;99(8):1290-5
references: 18813308
references: Int J Colorectal Dis. 2009 Aug;24(8):875-84
references: 19421758
references: Virchows Arch. 2013 Apr;462(4):399-407
references: 23494713
references: Mol Cancer Ther. 2008 Feb;7(2):280-5
references: 18281513
references: Int J Cancer. 2004 Dec 20;112(6):1029-35
references: 15386348
references: Eur J Cancer. 2010 Mar;46(5):944-53
references: 20060709
references: J Clin Pathol. 2009 Feb;62(2):152-8
references: 18930986
references: Int J Mol Sci. 2012;13(2):2208-18
references: 22408448
references: Clin Cancer Res. 2006 May 15;12(10):3057-63
references: 16707602
references: Clin Cancer Res. 2005 Jun 15;11(12):4357-64
references: 15958618
references: Int J Cancer. 2002 Oct 1;101(4):353-9
references: 12209960
references: J Clin Pathol. 2007 Jun;60(6):656-60
references: 16775124
references: Virchows Arch. 2007 Mar;450(3):355-8
references: 17252228
references: Exp Mol Pathol. 2013 Feb;94(1):73-8
references: 23031786
references: Int J Cancer. 1998 Jan 19;75(2):324-30
references: 9462726
references: Diagn Pathol. 2012 Dec 13;7:178
references: 23237707
references: J Exp Clin Cancer Res. 2012 Dec 12;31:101
references: 23231769
references: Int J Hematol. 2008 Mar;87(2):110-117
references: 18256789
references: Oral Oncol. 2007 Jan;43(1):4-14
references: 17064952
references: Proc Natl Acad Sci U S A. 1981 Aug;78(8):5147-50
references: 7029529