title: Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks.
abstract: The effects of Dangguibuxue Tang (DBT) on growth performance and immunity response in immunosuppressed broiler chicks were investigated in this study. 240 one-d-old broiler chicks (DaHeng S01) were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D). From 4 d to 7 d of age, chicks in group A, B and C were given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression. Chicks in group D were given an equal volume of physiological saline daily by intraperitoneal injection and considered normal chicks. Groups A and B were supplemented with 2.0% or 0.5% of DBT in the drinking water from 8 d to 42 d of age. Groups C and D did not receive any additional medication. The results revealed that chicks from group B had lower feed:gain rate (FGR), lower total mortality, higher immunity organ indexes, higher levels of Newcastle disease (ND) antibody and infectious bursal disease (IBD) antibody, higher interleukin-2 and interleukin-6 levels, and greater lymphocyte proliferative responses to concanavalin A (ConA) during the experiment than those from group C. However, no significant difference in the immunity status in the two levels of DBT-treatment was observed. These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks.
authors: Institute of Veterinary Pharmacology, Sichuan Animal Science Academy, Chengdu, China, 610066. lixutingzy@163.com
authors: Xu Ting
authors: XT
authors: Li
authors: Bin
authors: B
authors: Wang
authors: Jin Liang
authors: JL
authors: Li
authors: Rui
authors: R
authors: Yang
authors: Si Cong
authors: SC
authors: Li
authors: Min
authors: M
authors: Zhang
authors: Wei
authors: W
authors: Huang
authors: Liang
authors: L
authors: Cao
mesh_terms: D029971:Angelica sinensis; D000818:Animals; D027883:Astragalus Plant; D018175:Birnaviridae Infections / Q000276:immunology / Q000662:veterinary*; D002645:Chickens / Q000254:growth & development / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007165:Immunosuppression Therapy / Q000379:methods / Q000662:veterinary; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007243:Infectious bursal disease virus / Q000276:immunology*; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D009521:Newcastle Disease / Q000276:immunology*; D011897:Random Allocation
chemical_list: D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D015850:Interleukin-6; C477279:danggui buxue decoction; D003520:Cyclophosphamide