title: Serum microRNA-92 expression in patients with ovarian epithelial carcinoma.
abstract: OBJECTIVE
  Studies have reported the significance of circulating microRNAs (miRNAs) as biochemical markers of cancer. Few reports demonstrate the significance of miRNAs in the serum of patients with ovarian epithelial carcinoma (EOC). The present study prospectively investigated the status of miRNA-92 (miR-92) in the serum of EOC patients and healthy controls, and examined the potential usefulness of this molecule as a biomarker for EOC diagnosis.
  
  
  METHODS
  Levels of miR-92 in serum samples from EOC patients and controls were measured by quantitative real time reverse transcription-polymerase chain reaction (RT-PCR). Associations between serum miR-92 concentrations and clinical parameters were assessed by Fisher's exact probability test.
  
  
  RESULTS
  The serum concentration of miR-92 in EOC patients (n = 50) was significantly higher than in controls (n = 50). There were significant correlations between miR-92 expression and regional lymph node involvement and clinical stage of the tumour. There was no significant association between expression of miR-92 and age.
  
  
  CONCLUSIONS
  The detection of miR-92 levels in the serum might serve as a new tumour biomarker in the diagnosis and assessment of prognosis of EOC.
authors: Department of Obstetrics and Gynaecology, The Second Hospital, Jilin University, Changchun, China.
authors: Fengjun
authors: F
authors: Guo
authors: Jingyan
authors: J
authors: Tian
authors: Yang
authors: Y
authors: Lin
authors: Yuemei
authors: Y
authors: Jin
authors: Ling
authors: L
authors: Wang
authors: Manhua
authors: M
authors: Cui
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016013:Likelihood Functions; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; C541874:MIRN92 microRNA, human; D035683:MicroRNAs
keywords: clinical stage; miR-92; microRNA-92; ovarian epithelial carcinoma; regional lymph node involvement; serum; tumour marker