title: [En bloc excision and reconstruction of the defect with pasteurized autograft for femoral primary malignant bone tumor in children].
abstract: OBJECTIVE
  To evaluate the efficacy of femoral primary malignant bone tumors treated by limb salvage, with wide en bloc excision and reconstruction of the defect with recycled pasteurized autograft.
  
  
  METHODS
  From January 2008 to January 2011, 11 patients (7 males, 4 females), aged (11.0±2.5) years suffering from femoral primary malignant bone tumors were treated with en bloc excision and reconstruction of the defect with recycled pasteurized autograft. Ten patients were histopathologically diagnosed with high-grade osteosarcoma, and 1 with Ewing's sarcoma.According to the Enneking staging system, all patients were in Stage IIb.
  
  
  RESULTS
  All patients were followed-up for 24-65(42±20) months and all showed bony union at the last follow-up. The length of tumor bone resection was (17.5±3.2) cm, the operation time was (180±35) min, the intraoperative blood loss was (1200±250) mL, and drainage volume was (650±125) mL. Local skin necrosis occurred in 1 patient (9.1%), which was resolved by debridement. Nonunion occurred in 3 patients (27.3%), who were treated by secondary iliac crest cancellous bone grafting.Pulmonary metastasis occurred in 1 patient (9.1%) who died 35 months post-operatively. According to the function assessment by the Enneking system, 5 patients had excellent results, 4 had good results, 1 fair and 1 poor results, with a satisfaction rate of 81.2%.
  
  
  CONCLUSIONS
  A pasteurized autograft can be an easily accessible and economical alternative for children's malignant bone tumor of femurs.
authors: Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors: Qing
authors: Q
authors: Zhang
authors: Tang
authors: T
authors: Liu
authors: Xiaoning
authors: X
authors: Guo
authors: Ling
authors: L
authors: Lin
mesh_terms: D000293:Adolescent; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D002681:China; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D009367:Neoplasm Staging; D018215:Osteoblastoma / Q000601:surgery*; D061352:Pasteurization; D019651:Plastic Surgery Procedures / Q000379:methods; D020127:Recovery of Function; D014182:Transplantation, Autologous / Q000379:methods