title: The effects of age and viral serology on γδ T-cell numbers and exercise responsiveness in humans.
abstract: γδ T-cells are cytotoxic effector cells that preferentially migrate to peripheral tissues and recognize many types of antigen. We examined the effects of age and viral serology on the exercise responsiveness of γδ T-cells. Blood was collected from 17 younger (age: 23-35yrs) and 17 older (50-64yrs) healthy males matched for cytomegalovirus (CMV), Epstein-Barr virus, herpes simplex virus-1 and Parvovirus B19 serologic status before and after a single bout of cycling exercise. Older had lower numbers and proportions of γδ T-cells than younger, while CMV was associated with increased numbers and proportions of γδ T-cells in younger but not older. Exercise evoked a ∼2-fold increase in circulating γδ T-cell numbers. The magnitude of this response was 3-times greater in younger compared to older, and 1.6-times greater in younger CMV-infected compared to younger non CMV-infected. To conclude, γδ T-cell numbers and exercise responsiveness decreases with age and may contribute to impaired immunosurveillance after acute acute physical stress.
authors: Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX 77204, USA.
authors: Mira
authors: M
authors: Pistillo
authors: Austin B
authors: AB
authors: Bigley
authors: Guillaume
authors: G
authors: Spielmann
authors: Emily C
authors: EC
authors: LaVoy
authors: Mark R
authors: MR
authors: Morrison
authors: Hawley
authors: H
authors: Kunz
authors: Richard J
authors: RJ
authors: Simpson
mesh_terms: D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000302:isolation & purification; D015444:Exercise / Q000502:physiology*; D005434:Flow Cytometry; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D018139:Simplexvirus / Q000302:isolation & purification; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Cytomegalovirus; Epstein-Barr virus; Exercise immunology; Herpes simplex virus; Immunosenescence; Parvovirus B19