title: Stability of Lisinopril Syrup (2 mg/mL) Extemporaneously Compounded from Tablets.
abstract: The stability of lisinopril syrup (2 mg/mL) extemporaneously compounded from tablets was investigated. Zestril tablets (Lot CSC201, Zeneca Pharmaceuticals, Wilmington, Del) were crushed, dissolved in water, filtered, and diluted with syrup NF to a final nominal concentration of 2 mg/mL. The solution was then equally divided among amber-colored prescription bottles and was stored at 5 deg C and 23 deg C. During the 30-day study period, samples were extracted by means of a water:methanol mix, and the concentration of lisinopril was determined by a stability-indicating high-performance liquid chromatography assay procedure. Stability was also determined by pH measurements annd visual inspection for color or clarity change. Over the 30-day study period, the percentage of the inital lisinopril concentration remained between 99.42% +/- 0.19% and 95.68% +/- 1.5% for the 5 deg C samples and 98.83% +/- 0.46% and 96.48% +/- 0.62% for the 23 deg C samples.
authors: Pharmacokinetics Center, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama.
authors: D J
authors: DJ
authors: Rose
authors: A A
authors: AA
authors: Webster
authors: B A
authors: BA
authors: English
authors: J M
authors: JM
authors: McGuire