title: Elasticity estimates from images of crawling waves generated by miniature surface sources.
abstract: We describe a surface-based approach to the generation of shear wave interference patterns, called crawling waves (CrW), within a medium and derive local estimates of biomechanical properties of tissue. In previous experiments, elongated bars operating as vibration sources were used to generate CrW propagation in samples. In the present study, however, a pair of miniature circular vibration sources was applied to the overlying skin to generate the CrW within the medium. The shape and position of the miniature sources make this configuration more applicable for in vivo implementation. A modified ultrasound imaging system is used to display the CrW propagation. A shear speed mapping algorithm is developed using a detailed analysis of the CrW. The proposed setup is applied to several biomaterials including a homogeneous phantom, an inhomogeneous phantom and an ex vivo human liver. The data are analyzed using the mapping algorithm to reveal the biomechanical properties of the biomaterials.
authors: Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York, USA.
authors: Alexander
authors: A
authors: Partin
authors: Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York, USA.
authors: Zaegyoo
authors: Z
authors: Hah
authors: Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
authors: Christopher T
authors: CT
authors: Barry
authors: Department of Radiology, University of Rochester Medical Center, Rochester, New York, USA.
authors: Deborah J
authors: DJ
authors: Rubens
authors: Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York, USA. Electronic address: kevin.parker@rochester.edu.
authors: Kevin J
authors: KJ
authors: Parker
mesh_terms: D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D066298:In Vitro Techniques; D008099:Liver / Q000000981:diagnostic imaging* / Q000502:physiology*; D008954:Models, Biological; D012542:Scattering, Radiation; D033081:Shear Strength / Q000502:physiology; D013016:Sound; D013314:Stress, Mechanical; D013499:Surface Properties; D014783:Viscosity
keywords: Crawling waves; Elasticity imaging; Local shear speed estimation; Shear waves; Sonoelastography
references: Ultrasound Med Biol. 2012 Feb;38(2):175-82
references: 22178165
references: IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Jul;54(7):1346-51
references: 17718323
references: Phys Med Biol. 2008 Aug 7;53(15):4063-80
references: 18612176
references: J Acoust Soc Am. 2001 Jul;110(1):625-34
references: 11508987
references: Ultrasound Med Biol. 2009 Feb;35(2):219-29
references: 19081665
references: Ultrasound Med Biol. 2008 Feb;34(2):276-88
references: 17935863
references: J Rehabil Res Dev. 1987 Spring;24(2):1-8
references: 3295197
references: Ultrasound Med Biol. 1998 Nov;24(9):1419-35
references: 10385964
references: Ultrasound Q. 2007 Dec;23(4):255-68
references: 18090836
references: Ultrasound Med Biol. 2007 Oct;33(10):1617-31
references: 17604902
references: Proc Inst Mech Eng H. 1999;213(3):203-33
references: 10420776
references: Ultrasound Med Biol. 1996;22(8):959-77
references: 9004420
references: Cancer Biomark. 2008;4(4-5):213-25
references: 18957712
references: J Acoust Soc Am. 2005 May;117(5):2705-12
references: 15957738
references: Ultrasound Med Biol. 1990;16(3):231-9
references: 1694603
references: Ultrasound Med Biol. 2003 Oct;29(10):1405-13
references: 14597337
references: Annu Rev Biomed Eng. 2003;5:57-78
references: 12704084
references: J Acoust Soc Am. 1999 May;105(5):2941-50
references: 10335643
references: Ultrason Imaging. 1991 Apr;13(2):111-34
references: 1858217
references: Phys Med Biol. 2004 Mar 21;49(6):911-22
references: 15104315
references: Phys Med Biol. 2011 Jan 7;56(1):R1-R29
references: 21119234
references: Science. 1998 Apr 3;280(5360):82-5
references: 9525861
references: Ultrasound Med Biol. 2003 Dec;29(12):1705-13
references: 14698338
references: Ultrasound Med Biol. 2012 Feb;38(2):312-23
references: 22178168
references: Phys Med Biol. 2000 Jun;45(6):1477-94
references: 10870705
references: IEEE Trans Ultrason Ferroelectr Freq Control. 1990;37(2):45-53
references: 18285015