title: Inflammation and gastrointestinal cancer: an overview.
abstract: Gastrointestinal cancers collectively rank as the most lethal cancers worldwide, and are strongly linked with chronic inflammation. Despite advances over the last decade into our understanding of the etiology of these malignancies, both from a host perspective and with respect to environmental factors, current treatment strategies comprising surgery, chemotherapy and/or radiotherapy are still associated with unacceptably poor patient survival rates. Accordingly, there is a pressing need to identify new molecular targets which can underpin the development of next-generation treatment strategies to improve patient outcomes, and serve as biomarkers for early disease detection. In this review we provide an updated discussion on the identity of such candidate molecules, with a focus on innate immune system regulators within the gastrointestinal mucosal epithelium which promote inflammation and tumorigenesis.
authors: Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Hiroyuki
authors: H
authors: Marusawa
authors: Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia. Electronic address: Brendan.Jenkins@monash.edu.
authors: Brendan John
authors: BJ
authors: Jenkins
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism; D004249:DNA Damage; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D016328:NF-kappa B; D050796:STAT3 Transcription Factor; D051193:Toll-Like Receptors
keywords: Gastrointestinal cancer; Inflammation; NF-κB; STAT3; TLRs