title: Reproducibility of speckle-tracking-based strain measures of left ventricular function in a community-based study.
abstract: BACKGROUND
  The reproducibility of echocardiographic measurements of myocardial strain, performed in a community-based setting, has not been reported previously.
  
  
  METHODS
  The reproducibility of left ventricular strain measurements was examined in two samples of 20 participants each from the Offspring Cohort of the Framingham Heart Study (mean age, 63 ± 9 years; 59% women). Two-dimensional speckle-tracking-based measurements of global peak left ventricular strain in systole were performed in the apical four-chamber, apical two-chamber, and midventricular parasternal short-axis views.
  
  
  RESULTS
  Interobserver intraclass correlation coefficients were ≥0.84 for all global strain measurements, with average coefficients of variation of ≤4% for global longitudinal and circumferential strain and <8% for global transverse and radial strain. For left ventricular strain measurements performed in each of the three views, intraobserver intraclass correlation coefficients were ≥0.91 among time points spanning a total 8-month period. The average coefficients of variation were <6% for global longitudinal and circumferential strain and <9% for global transverse and radial strain. Interobserver and intraobserver reproducibility findings were similar in analyses adjusting for frame rate.
  
  
  CONCLUSIONS
  Excellent reproducibility of global longitudinal and circumferential strain measurements and very good reproducibility of global transverse and radial strain measurements were observed. Taken together, these findings demonstrate the reproducibility of performing echocardiographic strain measurements in a large, epidemiologic community-based setting.
authors: Framingham Heart Study, Framingham, Massachusetts; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: scheng3@partners.org.
authors: Susan
authors: S
authors: Cheng
authors: Martin G
authors: MG
authors: Larson
authors: Elizabeth L
authors: EL
authors: McCabe
authors: Ewa
authors: E
authors: Osypiuk
authors: Birgitta T
authors: BT
authors: Lehman
authors: Plamen
authors: P
authors: Stanchev
authors: Jayashri
authors: J
authors: Aragam
authors: Emelia J
authors: EJ
authors: Benjamin
authors: Scott D
authors: SD
authors: Solomon
authors: Ramachandran S
authors: RS
authors: Vasan
mesh_terms: D000368:Aged; D004452:Echocardiography / Q000706:statistics & numerical data*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D015588:Observer Variation; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology*
keywords: A2C; A4C; Apical four-chamber; Apical two-chamber; Epidemiology; ICC; Intraclass correlation coefficient; LV; Left ventricular; Myocardial deformation; SAX; Short-axis; Speckle-tracking; Strain
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