title: JAG1 mutation in a patient with deletion 22q11.2 syndrome and tetralogy of Fallot.
abstract: Deletion 22q11.2 (del22q11.2) syndrome, also known as DiGeorge/Velo-cardio-facial syndrome (DG/VCFS), and Alagille syndrome are genetic disorders characteristically associated with congenital heart defects (CHDs). We report on a patient with tetralogy of Fallot (TOF) and clinical features of DG/VCFS, hemizygous for del22q11.2 and heterozygous for the 2810G > A (p.Arg937Gln) mutation in the JAG1 gene associated with Alagille syndrome. The clinical features of del22q11.2 syndrome are present in the patient, including facial anomalies, typical TOF, speech delay with hypernasal voice, and learning difficulties. TOF and mild hepatic involvement, consisting of slightly elevated aminotransferase conjugated bilirubin levels, were the only features of Alagille syndrome in our patient. The anatomic type of TOF displayed no distinctive recognizable pattern for either DG/VCFS or Alagille syndrome. It is likely that hemizygosity of the TBX1 gene was causally related to TOF in this patient, although a synergistic pathogenic role of the JAG1 gene mutation in causing the heart defect cannot be excluded. JAG1 mutations have been previously detected in patients with nonsyndromic TOF and recent molecular evidence supports the cumulative effect of multiple genetic defects in the etiology of human malformations. We hypothesize that a similar mechanism could be present in this patient with del22q11.2 syndrome associated with a JAG1 missense mutation acting as possible modifier factor for TOF.
authors: Medical Genetics and Cytogenetics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
authors: Maria Cristina
authors: MC
authors: Digilio
authors: Alessandro De
authors: AD
authors: Luca
authors: Francesca
authors: F
authors: Lepri
authors: Valentina
authors: V
authors: Guida
authors: Rosangela
authors: R
authors: Ferese
authors: Maria Lisa
authors: ML
authors: Dentici
authors: Adriano
authors: A
authors: Angioni
authors: Bruno
authors: B
authors: Marino
authors: Bruno
authors: B
authors: Dallapiccola
mesh_terms: D016738:Alagille Syndrome / Q000235:genetics / Q000503:physiopathology; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002648:Child; D004062:DiGeorge Syndrome / Q000235:genetics* / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D000072100:Jagged-1 Protein; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020125:Mutation, Missense; D000072099:Serrate-Jagged Proteins; D020825:T-Box Domain Proteins / Q000235:genetics; D013771:Tetralogy of Fallot / Q000235:genetics* / Q000503:physiopathology
chemical_list: D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; C000606273:JAG1 protein, human; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D000072099:Serrate-Jagged Proteins; D020825:T-Box Domain Proteins; C108625:TBX1 protein, human
keywords: Alagille syndrome; DiGeorge/Velo-Cardio-Facial syndrome; JAG1 gene; deletion 22q11.2; tetralogy of Fallot