title: Graphene matrix for signal enhancement in ambient plasma assisted laser desorption ionization mass spectrometry.
abstract: In this work, the signal intensity of ambient plasma assisted laser desorption ionization mass spectrometry (PALDI-MS) was significantly increased with graphene as matrix. The graphene functions as a substrate to trap analytes, absorb energy from the visible laser irradiation and transfer energy to the analytes to facilitate the laser desorption process. The desorbed analytes are further ionized by helium plasma and analyzed by MS. Compared with a traditional organic matrix, α-cyano-4-hydroxycinnamic acid (CHCA), graphene exhibited much higher desorption efficiency for most of the compounds benefitting from the strong optical absorption at 532nm. The performance has been confirmed by the facile analysis of more than forty compounds with various structures. Additionally, this method was successfully applied to distinguish three kinds of Chinese tea leaves by detecting the endogenous caffeine and theanine, which proved the utility, facility and convenience of this method for rapid screening of main components in real samples.
authors: Beijing National Laboratory for Molecular Sciences, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors: Cuilan
authors: C
authors: Chang
authors: Xianjiang
authors: X
authors: Li
authors: Yu
authors: Y
authors: Bai
authors: Gege
authors: G
authors: Xu
authors: Baosheng
authors: B
authors: Feng
authors: Yiping
authors: Y
authors: Liao
authors: Huwei
authors: H
authors: Liu
mesh_terms: D000675:Ampyrone / Q000032:analysis; D002110:Caffeine / Q000032:analysis*; D028241:Camellia sinensis; D005971:Glutamates / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D009930:Organic Chemicals / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D010936:Plant Extracts / Q000032:analysis*; D018515:Plant Leaves; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D005971:Glutamates; D009930:Organic Chemicals; D004364:Pharmaceutical Preparations; D010936:Plant Extracts; D000675:Ampyrone; D002110:Caffeine; D006108:Graphite; C026166:theanine
keywords: Ambient PALDI-MS; Graphene; Graphene oxide; Signal enhancement; α-cyano-4-hydroxycinnamic acid