title: Evaluation of FDG-PET and ECD-SPECT in patients with subcortical band heterotopia.
abstract: OBJECTIVE
  The purpose of this retrospective study was to clarify the cellular activities of ectopic neurons in subcortical bands and to evaluate the imaging features of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and (99m)Tc ethyl cysteinate dimer (ECD) single-photon emission computed tomography (SPECT) in a series of patients with subcortical band heterotopia (SBH).
  
  
  METHODS
  The cases of 12 patients with SBH (3 men and 9 women; age range, 2-51 years) were evaluated on the basis of their MRI findings. Eight (18)F-FDG PET and 12 (99m)Tc-ECD SPECT images were obtained. The uptakes of these images were compared with electroencephalography (EEG) or MRI findings such as band thickness. In all patients, easy Z-score Imaging System (eZIS) software was used to statistically analyze the SPECT images.
  
  
  RESULTS
  Of the eight (18)F-FDG PET images, five showed higher uptake in the thick subcortical bands than in the overlying cortex. Of the 12 (99m)Tc-ECD SPECT examinations with eZIS images, nine indicated increased regional cerebral blood flow (rCBF) areas corresponding to the band locations. Of the eight (18)F-FDG PET examination findings, six were congruent with the rCBF distributions on the eZIS images. Eight of the 12 patients showed correspondence to the increased rCBF on the eZIS images, the band locations on MRI, and abnormal discharge sites on EEG.
  
  
  CONCLUSIONS
  Ectopic neurons in subcortical bands may have higher glucose metabolism and/or increased rCBF compared to the overlying cortex. (18)F-FDG PET and (99m)Tc-ECD SPECT using eZIS can be helpful to clearly detect the cellular activities of ectopic neurons in patients with SBH.
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address: itoukimiteru@yahoo.co.jp.
authors: Kimiteru
authors: K
authors: Ito
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Yasuhiro
authors: Y
authors: Nakata
authors: Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Matsuda
authors: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Kenji
authors: K
authors: Sugai
authors: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Masako
authors: M
authors: Watanabe
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Kouhei
authors: K
authors: Kamiya
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Yukio
authors: Y
authors: Kimura
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Yoko
authors: Y
authors: Shigemoto
authors: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Mitsutoshi
authors: M
authors: Okazaki
authors: Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Masayuki
authors: M
authors: Sasaki
authors: Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors: Noriko
authors: N
authors: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D054221:Classical Lissencephalies and Subcortical Band Heterotopias / Q000000981:diagnostic imaging*; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D055815:Young Adult
chemical_list: D015609:Organotechnetium Compounds; D019788:Fluorodeoxyglucose F18; C059659:technetium Tc 99m bicisate; D003545:Cysteine
keywords: Cerebral blood flow; Double cortex; FDG; PET; SPECT; Subcortical band heterotopia