title: Evolving pharmacology of orphan GPCRs: IUPHAR Commentary.
abstract: The award of the 2012 Nobel Prize in Chemistry to Robert Lefkowitz and Brian Kobilka for their work on the structure and function of GPCRs, spanning a period of more than 20 years from the cloning of the human β2 -adrenoceptor to determining the crystal structure of the same protein, has earned both researchers a much deserved place in the pantheon of major scientific discoveries. GPCRs comprise one of the largest families of proteins, controlling many major physiological processes and have been a major focus of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) since its inception in 1987. We report here recent efforts by the British Pharmacological Society and NC-IUPHAR to define the endogenous ligands of 'orphan' GPCRs and to place authoritative and accessible information about these crucial therapeutic targets online.
authors: Clinical Pharmacology Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors: Anthony P
authors: AP
authors: Davenport
authors: Anthony J
authors: AJ
authors: Harmar
mesh_terms: D022126:Access to Information; D000818:Animals; D003299:Cooperative Behavior; D057166:High-Throughput Screening Assays; D006801:Humans; D007391:International Cooperation; D008024:Ligands; D057093:Orphan Nuclear Receptors / Q000145:classification / Q000187:drug effects* / Q000378:metabolism; D010600:Pharmacology / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects*; D012958:Societies, Scientific; D009626:Terminology as Topic
chemical_list: D008024:Ligands; D057093:Orphan Nuclear Receptors
keywords: chemerin receptor; chemokine receptors; free fatty acid receptors; hydroxycarboxylic acid receptors; lysophosphatidic acid receptors; oxoglutarate receptor; succinate receptor
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