title: Kainate receptor RNA editing is markedly altered by acute spinal cord injury.
abstract: We have previously observed changes in the RNA editing of AMPA receptors after acute spinal cord injury (SCI); this implies that post-transcriptional modifications are capable of affecting the physiological properties of glutamate receptor channels and related signal transduction in this neurodegenerative condition. Here, we report that the editing of the ionotropic KAR is markedly decreased at both GluK1 and GluK2 Q/R sites in the epicenter of the lesion and with distinct magnitude and kinetics also in the caudal and rostral portions of the injured cord. These effects are persistent, being observed as late as 30 days after lesioning. In addition, also the I/V and Y/C sites of GluK2 were severely affected after SCI. These findings add novel information to the relevance of editing of glutamate receptors following acute SCI, thus expanding the recently emerged role of post-transcriptional mechanisms under these experimental conditions.
authors: Division of Biology and Genetics, Department of Molecular and Translational Medicine and National Institute of Neuroscience, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
authors: Luca
authors: L
authors: Caracciolo
authors: Fabio
authors: F
authors: Fumagalli
authors: Stephana
authors: S
authors: Carelli
authors: Laura
authors: L
authors: Madaschi
authors: Luca
authors: L
authors: La Via
authors: Daniela
authors: D
authors: Bonini
authors: Chiara
authors: C
authors: Fiorentini
authors: Sergio
authors: S
authors: Barlati
authors: Alfredo
authors: A
authors: Gorio
authors: Alessandro
authors: A
authors: Barbon
mesh_terms: D000818:Animals; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018092:Kainic Acid Receptors / Q000235:genetics / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D000097806:GluK2 Kainate Receptor
chemical_list: D012333:RNA, Messenger; D018092:Kainic Acid Receptors; D000097806:GluK2 Kainate Receptor
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