title: Calcitonin gene related peptide gene polymorphism in migraine patients.
abstract: OBJECTIVE
  Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine.
  
  
  METHODS
  One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP).
  
  
  RESULTS
  The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency.
  
  
  CONCLUSIONS
  Our study did not show any association between CALCA T-692C gene polymorphism and migraine.
authors: Department of Neurology, Trakya University Medical Faculty.
authors: Baburhan
authors: B
authors: Guldiken
authors: Tammam
authors: T
authors: Sipahi
authors: Remziye
authors: R
authors: Tekinarslan
authors: Levent
authors: L
authors: Kabayel
authors: Hulya
authors: H
authors: Ozkan
authors: Ayhan
authors: A
authors: Unlu
authors: Bilge Eren
authors: BE
authors: Yamasan
authors: Tulay
authors: T
authors: Okman-Kilic
authors: Nilda
authors: N
authors: Turgut
mesh_terms: D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D015740:Calcitonin Gene-Related Peptide