title: Evaluation of genetic polymorphisms in patients with multiple chemical sensitivity.
abstract: OBJECTIVE
  Multiple chemical sensitivity (MCS) is a chronic medical condition characterized by symptoms that the affect an individual's response to low-level chemical exposure. In this study, we identified a chemical sensitive population (CSP) and investigated the effect of genetic polymorphisms on their risk of chemical sensitivity.
  
  
  METHODS
  A quick environment exposure sensitivity (QEESI) questionnaire was used to survey 324 Japanese male workers whose DNA samples had been collected and stored. The following genes, which encode enzymes affecting the metabolic activation of a large number of xenobiotic compounds, were selected and analyzed in order to determine their influence on genetic predisposition to CSP: cytochrome P450 (CYP) 2E1, N-acetyl transferase (NAT) 2, glutathione S-transferase (GST) M1, GSTT1, GSTP1, low Km aldehyde dehydrogenase (ALDH2), and superoxide dismutase (SOD) 2.
  
  
  RESULTS
  Significant case-control distributed differences were observed in SOD2 polymorphisms and allele frequency distribution in high chemical sensitive subjects. Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.
  
  
  CONCLUSIONS
  We observed that high chemical sensitive individuals diagnosed by using Japanese criteria as MCS patients were more significantly associated with SOD2 polymorphisms.
authors: Department of Public Health, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. bjcxy860508@hotmail.com
authors: Xiaoyi
authors: X
authors: Cui
authors: Xi
authors: X
authors: Lu
authors: Mizue
authors: M
authors: Hiura
authors: Masako
authors: M
authors: Oda
authors: Wataru
authors: W
authors: Miyazaki
authors: Takahiko
authors: T
authors: Katoh
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018777:Multiple Chemical Sensitivity / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D062486:Public Health Surveillance; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics; D011795:Surveys and Questionnaires; D055815:Young Adult; D000099156:Superoxide Dismutase 2
chemical_list: D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2
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