title: Which drug-induced side effects would be tolerated in the prospect of seizure control?
abstract: There is ample evidence that side effects of antiepileptic pharmacotherapy negatively affect quality of life, adherence, and long-term retention. The study was set up to evaluate the anticipated tolerance of common side effects provided that a 50% or 100% reduction of seizure frequency would be achieved. An anonymous inquiry in 79 consecutive patients with epilepsy comprised questions regarding the severity of epilepsy/seizures and the perceived impact of seizures and drug treatment on daily functioning and a 10-tiered rating which assesses 11 common behavioral/psychiatric, cognitive, physiological, or physical side effects according to the degree to which they would be tolerated. Least acceptance was evident for psychiatric side effects followed by cognitive, physiological, and physical side effects. Weight gain and tiredness were the most tolerated side effects. The overall low acceptance of negative side effects was slightly higher in the case of a 100% vs. 50% seizure frequency reduction (28% vs. 21% of the maximum toleration score regarding all side effects). Surely, there is a trade-off between the severity of epilepsy, seizure control, and the acceptance of adverse treatment effects. However, the data disclose that psychiatric and cognitive side effects are least accepted. Thus, consideration of individual tolerance and monitoring of side effects in addition to seizures may increase adherence and therapy success.
authors: Department of Epileptology, University Clinic of Bonn, Germany. Electronic address: juri-alexander.witt@ukb.uni-bonn.de.
authors: Juri-Alexander
authors: JA
authors: Witt
authors: Christian E
authors: CE
authors: Elger
authors: Christoph
authors: C
authors: Helmstaedter
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000191:economics; D003072:Cognition Disorders / Q000139:chemically induced; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced; D012640:Seizures / Q000188:drug therapy* / Q000191:economics / Q000523:psychology; D012720:Severity of Illness Index
chemical_list: D000927:Anticonvulsants
keywords: Adverse events; Antiepileptic drugs; Cognition; Irritability; Memory; Mood; Seizure control; Treatment-emergent side effects