title: Gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia.
abstract: OBJECTIVE
  To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).
  
  
  METHODS
  From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi'an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.
  
  
  RESULTS
  Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.
  
  
  CONCLUSIONS
  Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.
authors: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
authors: Jiao
authors: J
authors: Yu
authors: Shi
authors: S
authors: Liu
authors: Xiu-Cai
authors: XC
authors: Fang
authors: Jun
authors: J
authors: Zhang
authors: Jun
authors: J
authors: Gao
authors: Ying-Lian
authors: YL
authors: Xiao
authors: Li-Ming
authors: LM
authors: Zhu
authors: Fen-Rong
authors: FR
authors: Chen
authors: Zhao-Shen
authors: ZS
authors: Li
authors: Pin-Jin
authors: PJ
authors: Hu
authors: Mei-Yun
authors: MY
authors: Ke
authors: Xiao-Hua
authors: XH
authors: Hou
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D004415:Dyspepsia / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D012893:Sleep Wake Disorders / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D015431:Weight Loss
chemical_list: D005765:Gastrointestinal Agents
keywords: Dyspeptic symptom score; Epigastric pain syndrome; Functional dyspepsia; Gastrointestinal symptoms; Helicobacter pylori infection; Postprandial distress syndrome; Rome III criteria
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