title: Overexpression of MACC1 protein and its clinical implications in patients with glioma.
abstract: Metastasis associated in colon cancer 1 (MACC1) has been regarded as a novel potential therapeutic target for multiple cancers. However, the impact of MACC1 in glioma remains unclear. The aim of this study was to analyze the correlation of MACC1 expression with the clinicopathological features of glioma. MACC1 mRNA and protein expression levels in human glioma tissues were detected by quantitative real-time polymerase chain reaction and immunohistochemistry assays, respectively. MACC1 mRNA and protein expression were both significantly higher in glioma tissues than in corresponding noncancerous brain tissues (both P < 0.001). In addition, statistical analysis suggested that high MACC1 expression was significantly correlated with advanced pathological grade (P = 0.004) and that patients with high expression of MACC1 protein exhibited a poorer prognosis than those with low MACC1 expression. Furthermore, Cox multivariate analysis showed that MACC1 overexpression was an independent prognostic factor for predicting the overall survival of glioma patients. In conclusion, expression of MACC1 in glioma could be adopted as a candidate biomarker for the diagnosis of clinical stage and for assessing prognosis, indicating for the first time that MACC1 may play an important role in the tumor development and progression in glioma. MACC1 might be considered as a novel therapeutic target against this cancer.
authors: Department of Neurosurgery, Chengdu Military General Hospital, No. 270, Tianhui Road, Rongdu Avenue, Chengdu, 610083, China.
authors: Tao
authors: T
authors: Yang
authors: Bin
authors: B
authors: Kong
authors: Yong-Qin
authors: YQ
authors: Kuang
authors: Lin
authors: L
authors: Cheng
authors: Jian-Wen
authors: JW
authors: Gu
authors: Jun-Hai
authors: JH
authors: Zhang
authors: Hai-Feng
authors: HF
authors: Shu
authors: Si-Xun
authors: SX
authors: Yu
authors: Wei-Qi
authors: WQ
authors: He
authors: Xue-Min
authors: XM
authors: Xing
authors: Hai-Dong
authors: HD
authors: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D005260:Female; D015870:Gene Expression; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D060888:Real-Time Polymerase Chain Reaction; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D047368:Tumor Burden
chemical_list: C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors
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