title: [ICU acquired neuromyopathy].
abstract: ICU acquired neuromyopathy (IANM) is the most frequent neurological pathology observed in ICU. Nerve and muscle defects are merged with neuromuscular junction abnormalities. Its physiopathology is complex. The aim is probably the redistribution of nutriments and metabolism towards defense against sepsis. The main risk factors are sepsis, its severity and its duration of evolution. IANM is usually diagnosed in view of difficulties in weaning from mechanical ventilation, but electrophysiology may allow an earlier diagnosis. There is no curative therapy, but early treatment of sepsis, glycemic control as well as early physiotherapy may decrease its incidence. The outcomes of IANM are an increase in morbi-mortality and possibly long-lasting neuromuscular abnormalities as far as tetraplegia.
authors: Pôle anesthésie réanimations soins intensifs blocs opératoires urgences (ARSIBOU), CHRU de Brest, boulevard Tanguy-Prigent, 29200 Brest, France; Laboratoire de physiologie, faculté de médecine et des sciences de la santé, EA 1274 (mouvement, sport santé), université de Bretagne-Occidentale, 22, avenue Camille-Desmoulins, 29200 Brest, France; Université européenne de Bretagne, 5, boulevard Laennec, 35000 Rennes, France. Electronic address: gildas.gueret@chu-brest.fr.
authors: G
authors: G
authors: Gueret
authors: M
authors: M
authors: Guillouet
authors: V
authors: V
authors: Vermeersch
authors: E
authors: E
authors: Guillard
authors: H
authors: H
authors: Talarmin
authors: B-V
authors: BV
authors: Nguyen
authors: F
authors: F
authors: Rannou
authors: M-A
authors: MA
authors: Giroux-Metges
authors: J-P
authors: JP
authors: Pennec
authors: Y
authors: Y
authors: Ozier
mesh_terms: D001284:Atrophy; D001786:Blood Glucose / Q000378:metabolism; D003422:Critical Care; D003937:Diagnosis, Differential; D006801:Humans; D015994:Incidence; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D009469:Neuromuscular Junction / Q000502:physiology; D018384:Oxidative Stress; D011379:Prognosis; D011782:Quadriplegia / Q000209:etiology; D012307:Risk Factors; D018805:Sepsis / Q000150:complications / Q000517:prevention & control; D015300:Ventilator Weaning
chemical_list: D001786:Blood Glucose
keywords: Canaux sodiques potentiel-dépendant; Neuromyopathie; Neuromyopathy; Physiopathologie; Physiopathology; Sepsis; Sequelae; Séquelles