title: Metabolites of Streptomyces sp., an endophytic actinomycete from Alpinia oxyphylla.
abstract: Four known compounds had been isolated from the Streptomyces sp. YIM66017, and their structures were elucidated by spectral analysis as 2,6-dimethoxy terephthalic acid (1), yangjinhualine A (2), α-hydroxyacetovanillone (3) and cyclo(Gly-Trp) (4). Compound 1 was isolated from natural resources for the first time, and compounds 2-4 were isolated from streptomycetes for the first time. The 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity assays showed that 1 showed higher activity than rutin with IC50 of 4.61 μg/mL and 2 showed the activity with IC50 of 57.12 μg/mL.
authors: a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , P.R. China.
authors: Hao
authors: H
authors: Zhou
authors: Yabin
authors: Y
authors: Yang
authors: Tianfeng
authors: T
authors: Peng
authors: Wei
authors: W
authors: Li
authors: Lixing
authors: L
authors: Zhao
authors: Lihua
authors: L
authors: Xu
authors: Zhongtao
authors: Z
authors: Ding
mesh_terms: D032429:Alpinia / Q000382:microbiology; D001713:Biphenyl Compounds / Q000494:pharmacology; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification; D010795:Phthalic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D012431:Rutin / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C000591282:2,6-dimethoxy terephthalic acid; D001713:Biphenyl Compounds; D004151:Dipeptides; D016166:Free Radical Scavengers; D010456:Peptides, Cyclic; D010795:Phthalic Acids; D010851:Picrates; C569085:cyclo(glycyltryptophyl); D012431:Rutin; C004931:1,1-diphenyl-2-picrylhydrazyl