title: Outcomes of methicillin-resistant Staphylococcus aureus infection after kidney and/or pancreas transplantation.
abstract: BACKGROUND
  The true extent of Methicillin-Resistant Staphylococcus aureus (MRSA) colonization and incidence of infection after solid organ transplantation in adults and children is not well-known. The aim of this study was to evaluate the incidence and the outcomes of MRSA infection following kidney and/or pancreas transplantation.
  
  
  METHODS
  We reviewed the case notes of all patients who developed MRSA colonization and infection within the first year of transplantation between September 2002 and December 2009. The primary endpoint of this study was mortality. The secondary endpoints included morbidity, graft failure, and length of hospital stay.
  
  
  RESULTS
  During the study period 1116 transplantations were performed. MRSA colonization was detected in 14 patients (1.25%) and infection occurred in 6 cases (0.53%) post-transplantation. Graft failure was not associated with MRSA colonization/infection in any of the cases. The mortality rate attributed to MRSA was 10% (n = 2). The overall median length of stay was 16 days (range, 6-243 days).
  
  
  CONCLUSIONS
  Our study demonstrates that the prevalence of MRSA colonization and infection in our unit is low in spite of immunosuppression. The incidence of MRSA infection was higher among patients who underwent pancreas transplantation. Patients who had MRSA colonization and then developed infection had higher morbidity and mortality rates.
authors: Renal and Pancreas Transplant Unit, Central Manchester University Hospitals Foundation Trust, Manchester, United Kingdom. melissacunha@doctors.org.uk
authors: M
authors: M
authors: Oliveira-Cunha
authors: V
authors: V
authors: Bowman
authors: G
authors: G
authors: di Benedetto
authors: M O
authors: MO
authors: Mitu-Pretorian
authors: S
authors: S
authors: Armstrong
authors: B
authors: B
authors: Forgacs
authors: A
authors: A
authors: Tavakoli
authors: T
authors: T
authors: Augustine
authors: R
authors: R
authors: Pararajasingam
mesh_terms: D000328:Adult; D000368:Aged; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000628:therapy; D004739:England / Q000453:epidemiology; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D007902:Length of Stay; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000401:mortality; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000628:therapy; D013997:Time Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents