title: PRENATAL INFECTION, MATERNAL IMMUNE ACTIVATION, AND RISK FOR SCHIZOPHRENIA.
abstract: A body of epidemiological literature has suggested an association between prenatal infection, subsequent maternal immune activation (MIA), and later risk of schizophrenia. These epidemiological studies have inspired preclinical research using rodent and primate models of prenatal infection and MIA. The findings from these preclinical studies indicate that severe infection and immune activation during pregnancy can negatively impact offspring brain development and impair adult behavior. This review aims to summarize the major epidemiological and preclinical findings addressing the connection between prenatal infection and immune activation and later risk of developing schizophrenia, as well as the more limited literature addressing the mechanisms by which this gestational insult might affect offspring neurodevelopment. Finally, directions for future research will be discussed.
authors: Division of Child and Adolescent Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, United States of America.
authors: Sarah E
authors: SE
authors: Canetta
authors: Alan S
authors: AS
authors: Brown
keywords: Cytokines; Maternal immune activation; Neurodevelopment; Polyinosinic-polycytosinic acid (Poly IC); Prenatal infection; Schizophrenia
references: J Mol Neurosci. 2010 Sep;42(1):112-9
references: 20393813
references: Neuron. 2009 Oct 15;64(1):93-109
references: 19840552
references: Nature. 2006 Apr 20;440(7087):1054-9
references: 16547515
references: J Neurosci. 2007 Oct 3;27(40):10695-702
references: 17913903
references: J Mol Endocrinol. 2007 Mar;38(3):377-82
references: 17339400
references: Biol Psychiatry. 2010 Dec 15;68(12):1172-81
references: 21130225
references: Dev Psychopathol. 2000 Summer;12(3):501-27
references: 11014750
references: Br J Psychiatry. 1992 Sep;161:390-3
references: 1393309
references: Exp Neurol. 2004 Dec;190(2):373-83
references: 15530876
references: J Psychiatr Res. 2005 May;39(3):311-23
references: 15725430
references: Schizophr Res. 2009 Mar;108(1-3):285-7
references: 19135339
references: Am J Psychiatry. 1994 Jun;151(6):922-4
references: 8185006
references: Schizophr Res. 1997 Jul 25;26(1):25-39
references: 9376335
references: PLoS One. 2012;7(1):e29754
references: 22238649
references: Neuroscience. 2006 Nov 17;143(1):51-62
references: 17045750
references: Neuropsychopharmacology. 2003 Oct;28(10):1778-89
references: 12865897
references: Biol Psychiatry. 2007 Mar 1;61(5):688-93
references: 16920078
references: Int J Neuropsychopharmacol. 2009 May;12(4):513-24
references: 18752727
references: Biol Psychiatry. 2002 Mar 15;51(6):480-4
references: 11922883
references: Am J Psychiatry. 2000 Mar;157(3):438-43
references: 10698821
references: Eur Arch Psychiatry Clin Neurosci. 2006 Mar;256(2):72-6
references: 16091861
references: J Neurosci Res. 2008 Aug 1;86(10):2190-200
references: 18438922
references: Development. 2002 Sep;129(18):4249-60
references: 12183377
references: Arch Gen Psychiatry. 2001 Nov;58(11):1032-7
references: 11695949
references: Mol Psychiatry. 1999 Mar;4(2):145-54
references: 10208446
references: Neonatology. 2007;92(4):269-78
references: 17627093
references: Brain Res. 2008 Oct 3;1233:160-7
references: 18710655
references: J Psychiatr Res. 2004 May-Jun;38(3):335-45
references: 15003440
references: Schizophr Res. 2004 Nov 1;71(1):179-83
references: 15374585
references: PLoS One. 2008 Jul 09;3(7):e2595
references: 18612411
references: Schizophr Res. 2010 Aug;121(1-3):46-54
references: 20553865
references: Nat Genet. 2011 Sep 18;43(10):969-76
references: 21926974
references: Nat Neurosci. 2006 Oct;9(10):1284-93
references: 16964252
references: Am J Psychiatry. 1994 Oct;151(10):1496-8
references: 8092342
references: Brain Behav Immun. 2011 May;25(4):604-15
references: 21195166
references: J Neurosci. 2003 Jan 1;23(1):297-302
references: 12514227
references: Ann N Y Acad Sci. 2004 Jun;1018:281-7
references: 15240379
references: J Neurosci. 2006 May 3;26(18):4752-62
references: 16672647
references: Arch Gen Psychiatry. 1988 Feb;45(2):189-92
references: 3337616
references: Behav Brain Res. 2009 Dec 7;204(2):313-21
references: 19136031
references: Science. 2000 Dec 15;290(5499):2155-9
references: 11118151
references: Neuroscience. 2008 Jun 23;154(2):701-9
references: 18495356
references: Arch Gen Psychiatry. 1990 Sep;47(9):869-74
references: 2393346
references: Am J Psychiatry. 2004 May;161(5):889-95
references: 15121655
references: Brain Behav Immun. 2010 Aug;24(6):881-97
references: 20230889
references: Mol Psychiatry. 2010 Apr;15(4):372-83
references: 18414405
references: Am J Psychiatry. 2008 Jan;165(1):13-4
references: 18178751
references: Am J Psychiatry. 2009 Sep;166(9):1025-30
references: 19487391
references: Schizophr Res. 2008 Feb;99(1-3):56-70
references: 18248790
references: Cell. 2007 Dec 14;131(6):1164-78
references: 18083105
references: Br J Psychiatry. 1992 Apr;160:461-6
references: 1294066
references: Brain Res. 2009 Apr 10;1265:196-204
references: 19236855
references: Eur Neuropsychopharmacol. 2008 Oct;18(10):712-6
references: 18693086
references: Arch Gen Psychiatry. 2004 Aug;61(8):774-80
references: 15289276
references: Schizophr Res. 2009 Sep;113(2-3):288-97
references: 19464151
references: Lancet. 1991 May 25;337(8752):1248-50
references: 1674062
references: Biol Psychiatry. 2008 Apr 15;63(8):809-15
references: 17981263
references: Science. 2002 Mar 22;295(5563):2282-5
references: 11910117
references: Br J Psychiatry. 1994 May;164(5):674-6
references: 7921719
references: Free Radic Biol Med. 2007 Apr 15;42(8):1231-45
references: 17382204
references: Br J Psychiatry. 1996 Mar;168(3):368-71
references: 8833694
references: Brain Behav Immun. 2001 Dec;15(4):411-20
references: 11782107
references: J Neurosci. 2012 Jan 11;32(2):436-51
references: 22238080
references: Neuron. 2009 Oct 15;64(1):61-78
references: 19840550
references: Mov Disord. 2002 Jan;17(1):116-24
references: 11835448
references: Psychiatry Res. 2011 Jul 30;188(2):179-86
references: 21600665
references: Am J Psychiatry. 2009 Jun;166(6):683-90
references: 19369317
references: Am J Psychiatry. 2005 Apr;162(4):767-73
references: 15800151
references: Dev Neurobiol. 2012 Oct;72(10):1272-6
references: 22488761
references: Schizophr Bull. 2009 May;35(3):631-7
references: 18832344
references: Am J Psychiatry. 2010 Mar;167(3):261-80
references: 20123911
references: Am J Psychiatry. 2006 Dec;163(12):2178-80
references: 17151171
references: Brain Behav Immun. 2008 May;22(4):469-86
references: 18023140
references: Hippocampus. 2008;18(6):602-9
references: 18306297