title: Can pharmaco-electroencephalography help improve survival of central nervous system drugs in early clinical development?
abstract: Pharmaco-electroencephalography has significant yet unrealised promise as a translatable intermediate biomarker of central pharmacodynamic activity that could help reduce Phase 2 attrition in the development of central nervous system drugs. In an effort to understand its true potential, a framework for decision-making was proposed and the utility of pharmaco-electroencephalography was assessed through several case studies. A key finding was that lack of standardisation reduces the value of data pooling and meta-analyses and renders assessment of translatability difficult, limiting utility in all but simple cases. Pre-competitive collaboration is essential both to improving understanding of translation and developing modern signal processing techniques.
authors: Medical Imaging and Physiological Measurements Consultant, Canterbury, Kent, UK. Electronic address: fred.wilson@physics.org.
authors: Frederick J
authors: FJ
authors: Wilson
authors: Lundbeck Research USA, Inc., 215 College Road, Paramus, NJ 07652, USA.
authors: Steven C
authors: SC
authors: Leiser
authors: Science for Life Laboratory (SciLifeLab Stockholm), AstraZeneca Research and Development, Tomtebodavägen 23, S-171 65 Solna, Sweden.
authors: Magnus
authors: M
authors: Ivarsson
authors: Clinical Pharmacology, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark.
authors: Søren R
authors: SR
authors: Christensen
authors: Synaptic Transmission, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark.
authors: Jesper F
authors: JF
authors: Bastlund
mesh_terms: D000818:Animals; D015415:Biomarkers; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003299:Cooperative Behavior; D003657:Decision Making; D015195:Drug Design; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: D015415:Biomarkers; D002491:Central Nervous System Agents