title: New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children.
abstract: Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.
authors: Department of Pediatrics, University of Chieti, Chieti, Italy. gasparistefania@libero.it.
authors: Stefania
authors: S
authors: Gaspari
authors: Manuela
authors: M
authors: Marsili
authors: Massimo
authors: M
authors: Imazio
authors: Antonio
authors: A
authors: Brucato
authors: Chiara
authors: C
authors: Di Blasi Lo Cuccio
authors: Francesco
authors: F
authors: Chiarelli
authors: Luciana
authors: L
authors: Breda
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010493:Pericarditis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D003078:Colchicine