title: Angioedema with normal laboratory values: the next step.
abstract: When faced with a patient with recurrent swelling, a thorough laboratory evaluation to determine the underlying etiology ensues. When the laboratory work-up is unrevealing, health care practitioners are frequently left in a quandary. This review will attempt to provide up-to-date information on how to approach the diagnosis and management of angioedema in a patient with normal laboratory values. The subtypes that will be reviewed in detail include: hereditary angioedema with normal C1 inhibitor (HAE with normal C1INH), drug-induced angioedema, and idiopathic angioedema. We present literature to aid the physician in the diagnosis and treatment of these disorders.
authors: Rheumatology, Allergy & Immunology, Winthrop University, 120 Mineola Blvd., Suite 410, Mineola, NY, 11501, USA, jsher@winthrop.org.
authors: Janelle
authors: J
authors: Sher
authors: Mark
authors: M
authors: Davis-Lorton
mesh_terms: D000799:Angioedema / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D050718:Complement C1 Inhibitor Protein; D003937:Diagnosis, Differential; D006801:Humans
chemical_list: D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human
references: Thromb Res. 1994 Jun 1;74(5):477-85
references: 8085248
references: Br J Dermatol. 2007 May;156(5):1063-5
references: 17381464
references: Allergy Asthma Clin Immunol. 2010 Jul 28;6(1):15
references: 20667118
references: Am J Obstet Gynecol. 2010 Aug;203(2):131.e1-7
references: 20471627
references: Immunol Allergy Clin North Am. 2006 Nov;26(4):753-67
references: 17085289
references: Immunol Allergy Clin North Am. 2006 Nov;26(4):725-37
references: 17085287
references: Diabet Med. 2010 Apr;27(4):486-7
references: 20536525
references: Medicine (Baltimore). 1992 Jul;71(4):206-15
references: 1518394
references: Ann Allergy Asthma Immunol. 2008 Nov;101(5):495-9
references: 19055203
references: Thromb Res. 1981 Aug 15-Sep 1;23(4-5):453-5
references: 7324006
references: Eur J Obstet Gynecol Reprod Biol. 2010 Sep;152(1):44-9
references: 20541309
references: Allergy Asthma Proc. 2012 Nov-Dec;33 Suppl 1:S145-56
references: 23394603
references: Lancet. 2000 Jul 15;356(9225):213-7
references: 10963200
references: Immunol Allergy Clin North Am. 2006 Nov;26(4):669-90
references: 17085284
references: J Am Coll Cardiol. 2006 May 16;47(10):2130-9
references: 16697342
references: Am J Med. 2007 Nov;120(11):987-92
references: 17976427
references: Pathology. 2008 Jan;40(1):82-3
references: 18038321
references: J Allergy Clin Immunol. 2001 Apr;107(4):747-8
references: 11295676
references: Ann Allergy Asthma Immunol. 2009 Nov;103(5):448
references: 19927548
references: Hypertension. 2001 Jan;37(1):46-51
references: 11208755
references: Thromb Haemost. 1991 Feb 12;65(2):134-8
references: 2053098
references: Br J Dermatol. 2004 Jan;150(1):157-8
references: 14746637
references: Am J Obstet Gynecol. 2008 Nov;199(5):484.e1-4
references: 18554570
references: Transfus Apher Sci. 2003 Dec;29(3):239-45
references: 14572816
references: Drug Saf. 1998 Mar;18(3):171-88
references: 9530537
references: Am J Kidney Dis. 2004 May;43(5 Suppl 1):S1-290
references: 15114537
references: World Allergy Organ J. 2012 Nov;5(11):125-47
references: 23282382
references: Ann Pharmacother. 2000 Apr;34(4):526-8
references: 10772441
references: Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):337-44
references: 23743513
references: Obstet Gynecol Int. 2010;2010:957507
references: 20490261
references: J Allergy Clin Immunol. 2009 Jul;124(1):129-34
references: 19477491
references: World Allergy Organ J. 2008 Jun;1(6):103-13
references: 23282406
references: Allergy. 2009 Feb;64(2):284-6
references: 19178407
references: Biochem Biophys Res Commun. 2006 May 19;343(4):1286-9
references: 16638441
references: CMAJ. 2006 Oct 24;175(9):1065-70
references: 17060655
references: Clin Rev Allergy Immunol. 2002 Oct;23(2):217-31
references: 12221866
references: J Hypertens. 2011 Nov;29(11):2273-7
references: 21970934
references: Am J Med. 1960 Aug;29:193-216
references: 13693909
references: Blood. 1985 Sep;66(3):602-5
references: 4027381
references: Thromb Res. 1999 Feb 15;93(4):161-70
references: 10064271
references: Dtsch Med Wochenschr. 2000 Apr 7;125(14):427-8
references: 10812367
references: Hypertension. 2009 Sep;54(3):516-23
references: 19581505
references: Drug Saf. 2001;24(8):599-606
references: 11480492
references: J Lab Clin Med. 1991 May;117(5):343
references: 2019788
references: Chest. 2004 Aug;126(2):400-4
references: 15302724
references: Allergy. 2010 Oct;65(10):1331-6
references: 20384613
references: Br J Obstet Gynaecol. 1993 Jan;100(1):79-84
references: 8427844
references: Ann Allergy Asthma Immunol. 2008 Apr;100(4):327-32
references: 18450117
references: Indian J Dermatol. 2011 Nov;56(6):622-8
references: 22345759
references: Can J Anaesth. 2006 Oct;53(10):994-1003
references: 16987854
references: J Allergy Clin Immunol. 2000 Sep;106(3):546-50
references: 10984376
references: J Allergy Clin Immunol. 1992 Sep;90(3 Pt 1):412-3
references: 1527327
references: J Allergy Clin Immunol. 2012 Feb;129(2):308-20
references: 22197274
references: Br J Dermatol. 2006 Mar;154(3):542-5
references: 16445789
references: J Allergy Clin Immunol. 2004 Sep;114(3 Suppl):S51-131
references: 15356535
references: Diabetes Care. 2012 Aug;35(8):e60
references: 22826453
references: Clin Immunol. 2005 Jan;114(1):10-6
references: 15596404
references: Allergy Asthma Clin Immunol. 2010 Jul 28;6(1):24
references: 20667127
references: Clin Immunol. 2005 Jan;114(1):3-9
references: 15596403