title: The effect of oxoguanine glycosylase 1 rs1052133 polymorphism on colorectal cancer risk in Caucasian population.
abstract: Human oxoguanine glycosylase 1 (OGG1) is an important part of the base excision repair pathway in the DNA repair. Numerous epidemiological studies have evaluated the association between OGG1 rs1052133 polymorphism and the risk of colorectal cancer, but the results of these studies from the Caucasian population were conflicting. To derive a more precise assessment on the association between OGG1 rs1052133 polymorphism and risk of colorectal cancer in Caucasian population, we performed a meta-analysis. The odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of the association. Thirteen case-control studies with a total of 4,103 cases and 5,400 controls were finally included into the meta-analysis. Meta-analysis of all 13 studies showed that OGG1 rs1052133 polymorphism was significantly associated with the risk of colorectal cancer in Caucasian population (Cys versus Ser OR = 1.20, 95% CI = 1.03-1.39, P = 0.02; CysCys versus SerSer OR = 1.44, 95% CI = 1.04-2.00, P = 0.03; CysCys versus SerSer/SerCys OR = 1.39, 95% CI = 1.15-1.67, P = 0.0005). In the sensitivity analysis, omitting each study one at a time had no obvious influence on the pooled OR, which confirmed the stability of meta-analysis. The meta-analysis suggests that OGG1 rs1052133 polymorphism is significantly associated with the risk of colorectal cancer in Caucasian population.
authors: Department of Minimally Invasive Surgery, Shanghai East Hospital, Shanghai, 200120, China.
authors: Yuantao
authors: Y
authors: Su
authors: Anan
authors: A
authors: Xu
authors: Jiangfan
authors: J
authors: Zhu
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D003062:Codon; D015179:Colorectal Neoplasms / Q000235:genetics*; D045647:DNA Glycosylases / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D044465:White People / Q000235:genetics*
chemical_list: D003062:Codon; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human
references: Mutat Res. 2008 Feb 1;638(1-2):146-53
references: 17991492
references: J Cancer Res Clin Oncol. 2012 Sep;138(9):1443-8
references: 22526153
references: Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3384-8
references: 19959686
references: Mutagenesis. 2010 Sep;25(5):463-71
references: 20534734
references: Am J Epidemiol. 2010 Nov 1;172(9):1000-14
references: 20937634
references: Tohoku J Exp Med. 2009 Jul;218(3):185-91
references: 19561388
references: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references: 21296855
references: Cancer Lett. 2005 Nov 8;229(1):85-91
references: 15946795
references: Ann Intern Med. 2011 Jan 4;154(1):37-49
references: 21200037
references: Cell. 2013 Mar 14;152(6):1344-54
references: 23498941
references: Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3167-73
references: 21037106
references: J Clin Oncol. 2009 Feb 10;27(5):663-71
references: 19114683
references: Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2101-8
references: 16609022
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Tumour Biol. 2012 Dec;33(6):2041-51
references: 22890827
references: DNA Cell Biol. 2012 Apr;31(4):541-6
references: 21899442
references: PLoS One. 2012;7(4):e35970
references: 22540013
references: Curr Med Res Opin. 2011 Jul;27(7):1295-302
references: 21561390
references: Nature. 2007 Jun 21;447(7147):941-50
references: 17581577
references: Mutat Res. 2013 May-Jun;745-746:6-15
references: 23618615
references: Carcinogenesis. 2010 Feb;31(2):228-33
references: 19933708
references: Mutat Res. 2009 May 12;664(1-2):13-9
references: 19428376
references: PLoS One. 2013 Jun 06;8(6):e65742
references: 23762419
references: Genet Test Mol Biomarkers. 2010 Aug;14(4):559-64
references: 20649433
references: J Radiat Res. 2008 Jul;49(4):329-40
references: 18596371
references: Mol Biol Rep. 2012 Jan;39(1):527-34
references: 21559836
references: Hum Exp Toxicol. 2012 Oct;31(10):981-1005
references: 23023028