title: Dose-response association of physical activity with acute myocardial infarction: do amount and intensity matter?
abstract: OBJECTIVE
  The aims of this study were to analyze the dose-response association between leisure time physical activity (PA) practice and myocardial infarction (MI), considering not only the total amount but also the amount of PA at different levels of intensity, and to determine whether these associations were modified by age.
  
  
  METHODS
  In a population-based age- and sex-matched case-control study, all first acute MI patients aged 25 to 74 years were prospectively registered in four Spanish hospitals between 2002 and 2004. Controls were randomly selected from population-based samples recruited during the same period of time. The Minnesota PA questionnaire was administered to assess total energy expenditure in PA and in light-, moderate-, and high-intensity PA.
  
  
  RESULTS
  Finally, 1339 cases and 1339 controls were included. The association between PA and MI likelihood was non-linear, with significantly lower MI odds at low practice levels (≥ 500 MET·min/week), lowest odds around 1500 MET·min/week, and a plateau thereafter. Light- (in subjects older than 64 years), moderate-, and high-intensity PA produced similar benefits.
  
  
  CONCLUSIONS
  Most of the population could reduce their likelihood of MI by engaging in PA at a moderate level of intensity or, in individuals older than 64 years, at a light level of intensity.
authors: Grupo de Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública, Barcelona, Spain. Electronic address: relosua@imim.es.
authors: Roberto
authors: R
authors: Elosua
authors: Ana
authors: A
authors: Redondo
authors: Antonio
authors: A
authors: Segura
authors: Miquel
authors: M
authors: Fiol
authors: Elena
authors: E
authors: Aldasoro
authors: Gema
authors: G
authors: Vega
authors: Jordi
authors: J
authors: Forteza
authors: Helena
authors: H
authors: Martí
authors: José María
authors: JM
authors: Arteagoitia
authors: Jaume
authors: J
authors: Marrugat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007899:Leisure Activities; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control*; D016017:Odds Ratio; D005082:Physical Exertion; D012737:Sex Factors; D013030:Spain
keywords: CHD; EEPA; Exercise; MET; MI; Myocardial infarction; PA; Physical activity; Prevention; Public health; coronary heart disease; expenditure energy physical activity; metabolic equivalent; myocardial infarction; physical activity