title: Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44.
abstract: Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
authors: Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. lichunshun@ms.qdio.ac.cn
authors: Chun-Shun
authors: CS
authors: Li
authors: Xiao-Ming
authors: XM
authors: Li
authors: Shu-Shan
authors: SS
authors: Gao
authors: Yan-Hua
authors: YH
authors: Lu
authors: Bin-Gui
authors: BG
authors: Wang
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D019015:Geologic Sediments; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010407:Penicillium / Q000737:chemistry*; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D062367:ortho-Aminobenzoates; C575516:penicacid A; C031385:anthranilic acid; D009173:Mycophenolic Acid
references: J Immunol Methods. 1983 Dec 16;65(1-2):55-63
references: 6606682
references: Appl Microbiol Biotechnol. 2003 Oct;62(5-6):446-58
references: 12838377
references: J Nat Prod. 2011 May 27;74(5):1331-4
references: 21495659
references: J Nat Prod. 2012 Feb 24;75(2):148-52
references: 22283451
references: Chembiochem. 2002 Jul 2;3(7):619-27
references: 12324995
references: J Ethnopharmacol. 2005 Jan 4;96(1-2):107-12
references: 15588657
references: Org Biomol Chem. 2009 May 7;7(9):1753-60
references: 19590766
references: Fungal Genet Biol. 2011 Jan;48(1):15-22
references: 20433937
references: J Nat Prod. 2011 Feb 25;74(2):256-61
references: 21226488
references: J Nat Prod. 2007 Dec;70(12):1939-45
references: 18052326
references: J Nat Prod. 2011 Aug 26;74(8):1787-91
references: 21774474
references: Nat Prod Rep. 2011 Feb;28(2):290-344
references: 21229157
references: Chem Pharm Bull (Tokyo). 2005 Aug;53(8):907-10
references: 16079517
references: Bioorg Med Chem Lett. 2012 Jul 15;22(14):4650-3
references: 22727636
references: Nat Prod Rep. 2010 Feb;27(2):165-237
references: 20111802
references: J Nat Prod. 2012 Nov 26;75(11):1888-95
references: 23148724
references: Nat Prod Rep. 2009 Feb;26(2):170-244
references: 19177222
references: Nat Prod Rep. 2011 Feb;28(2):196-268
references: 21152619
references: J Nat Prod. 2007 Nov;70(11):1731-40
references: 17988094