title: Hepatitis E virus infection in patients infected with human immunodeficiency virus in an endemic area in Iran.
abstract: Some studies have suggested that hepatitis E virus is more frequent in human immunodeficiency virus (HIV) patients and can progress to chronic infection. We aimed to determine the prevalence of hepatitis E virus antibodies and RNA in a series of 100 HIV-infected patients in Tehran, Iran, with comparison to 52 healthy HIV, hepatitis B and C-negative blood donors as controls. HIV-infected patients were also tested for hepatitis E virus-RNA. Among the HIV-infected patients, 10% had antibodies to hepatitis E virus - a finding not significantly different from the uninfected controls (11.5%). No HIV-infected patients had hepatitis E virus IgM antibodies nor did any have detectable hepatitis E virus-RNA. We found no associations between anti-hepatitis E virus IgG-seropositivity and age, sex, route of HIV acquisition, aminotransferases levels, CD4, antiretroviral therapy, hepatitis B virus and hepatitis C virus co-infection. Hepatitis E virus is relatively prevalent in our HIV-infected patients, although without evidence of chronic infection and no more common than among HIV-negative controls or the general population. For the present, we do not recommend routine screening for hepatitis E virus infection in HIV-infected patients in our moderately endemic region.
authors: Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.
authors: Amitis
authors: A
authors: Ramezani
authors: Ali Akbar
authors: AA
authors: Velayati
authors: Sara
authors: S
authors: Khorami-Sarvestani
authors: Ali
authors: A
authors: Eslamifar
authors: Minoo
authors: M
authors: Mohraz
authors: Mohammad
authors: M
authors: Banifazl
authors: Farahnaz
authors: F
authors: Bidari-Zerehpoosh
authors: Farhad
authors: F
authors: Yaghmaei
authors: Willi
authors: W
authors: McFarland
authors: Maryam
authors: M
authors: Foroughi
authors: Hossein
authors: H
authors: Keyvani
authors: Ehsan
authors: E
authors: Mostafavi
authors: Arezoo
authors: A
authors: Aghakhani
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D016752:Hepatitis E virus / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D017423:Sequence Analysis, RNA; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral
keywords: AIDS; HIV; Hepatitis E virus; Iran; chronic hepatitis E virus; co-infection; hepatitis; human immunodeficiency virus