title: A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring.
abstract: Micromachined viscometric affinity glucose sensors have been previously demonstrated using vibrational cantilever and diaphragm. These devices featured a single glucose detection module that determines glucose concentrations through viscosity changes of glucose-sensitive polymer solutions. However, fluctuations in temperature and other environmental parameters might potentially affect the stability and reliability of these devices, creating complexity in their applications in subcutaneously implanted continuous glucose monitoring (CGM). To address these issues, we present a MEMS differential sensor that can effectively reject environmental disturbances while allowing accurate glucose detection. The sensor consists of two magnetically driven vibrating diaphragms situated inside microchambers filled with a boronic-acid based glucose-sensing solution and a reference solution insensitive to glucose. Glucose concentrations can be accurately determined by characteristics of the diaphragm vibration through differential capacitive detection. Ourin-vitroand preliminaryin-vivoexperimental data demonstrate the potential of this sensor for highly stable subcutaneous CGM applications.
authors: Department of Mechanical Engineering, Columbia University, New York, NY 10027.
authors: Xian
authors: X
authors: Huang
authors: Siqi
authors: S
authors: Li
authors: Erin
authors: E
authors: Davis
authors: Charles
authors: C
authors: Leduc
authors: Yann
authors: Y
authors: Ravussin
authors: Haogang
authors: H
authors: Cai
authors: Bing
authors: B
authors: Song
authors: Dachao
authors: D
authors: Li
authors: Domenico
authors: D
authors: Accili
authors: Rudolph
authors: R
authors: Leibel
authors: Qian
authors: Q
authors: Wang
authors: Qiao
authors: Q
authors: Lin
keywords: Viscometric glucose sensor; affinity detection; differential measurement
references: Sensors (Basel). 2010;10(9):8248-74
references: 22163652
references: Diabetes Technol Ther. 2000 Autumn;2(3):461-72
references: 11467349
references: Analyst. 2012 Aug 21;137(16):3800-5
references: 22763782
references: J Diabetes Sci Technol. 2007 May;1(3):384-93
references: 19885094
references: Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:7670-3
references: 22256115
references: Anal Chim Acta. 2010 Feb 5;659(1-2):194-200
references: 20103124
references: Electrophoresis. 1996 Jun;17(6):1103-9
references: 8832178
references: Am J Physiol. 1999 Sep;277(3):E561-71
references: 10484370
references: Anal Chem. 2000 Sep 1;72(17):4185-92
references: 10994982
references: Diabetes Care. 2001 Sep;24(9):1696-7
references: 11522729
references: Biosens Bioelectron. 2011 Dec 15;30(1):223-8
references: 21996323
references: Sens Actuators B Chem. 2009 Jul 16;140(2):603-609
references: 24511207
references: Biosens Bioelectron. 2008 May 15;23(10):1458-65
references: 18304798
references: Biosens Bioelectron. 2002 Aug;17(8):641-6
references: 12052349
references: Chem Rev. 2008 Feb;108(2):814-25
references: 18154363
references: J Microelectromech Syst. 2009 Nov 13;18(6):1246-1254
references: 24511213
references: J Diabetes Sci Technol. 2011 Sep 01;5(5):1044-51
references: 22027296
references: Annu Rev Biomed Eng. 1999;1:153-75
references: 11701486
references: J Diabetes Sci Technol. 2007 Sep;1(5):617-23
references: 19885129
references: J Diabetes Sci Technol. 2012 Nov 01;6(6):1436-44
references: 23294791
references: Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17894-8
references: 20921374
references: Sensors (Basel). 2010;10(12):10936-52
references: 22163505
references: J Micromech Microeng. 2013 May;23(5):55020
references: 23956499
references: Biomed Opt Express. 2011 Apr 18;2(5):1243-57
references: 21559135
references: Diabetes Technol Ther. 2005 Feb;7(1):163-73
references: 15738714
references: Diabetes Care. 2011 May;34 Suppl 2:S197-201
references: 21525455
references: Diabetologia. 2001 Apr;44(4):416-23
references: 11357470
references: Diabetes Technol Ther. 2004 Dec;6(6):790-9
references: 15684631
references: Diabetes Care. 1982 May-Jun;5(3):245-53
references: 6184210
references: J Diabetes Sci Technol. 2009 Mar 01;3(2):242-52
references: 20144355
references: J Diabetes Sci Technol. 2008 Mar;2(2):300-6
references: 19885360
references: J Diabetes Sci Technol. 2011 Sep 01;5(5):1060-7
references: 22027298
references: Diabetes Technol Ther. 2009 Jun;11 Suppl 1:S11-6
references: 19469670
references: Diabetes Technol Ther. 2006 Feb;8(1):112-22
references: 16472058
references: Biosens Bioelectron. 2005 Nov 15;21(5):802-8
references: 16242621