title: Association of angiotensin II type-1 receptor A1166C gene polymorphism with the susceptibility of end-stage renal disease.
abstract: Association between angiotensin II type-1 receptor (AT1R) A1166C gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. This meta-analysis was performed to evaluate the association of AT1R A1166C gene polymorphism with ESRD susceptibility. The search was performed in the databases of PubMed, Embase and Cochrane Library as of 1 May 2012, and the eligible investigations were recruited for this meta-analysis. Nineteen literatures were identified for the analysis of association between AT1R A1166C gene polymorphism and ESRD susceptibility. There was no association between AT1R A1166C gene polymorphism and ESRD susceptibility for overall populations, Caucasians, Asians and Turkish population. Interestingly, CC genotype was associated with a higher risk of ESRD in Africans (OR = 3.36, 95% CI: 1.42-7.99, p = 0.006). However, C allele and AA genotype were not associated with the ESRD risk in African population. In conclusion, CC genotype might be a risk factor for the ESRD susceptibility in African population. However, more case-control association investigations on larger, stratified populations are required in the future.
authors: Department of Nephrology, The Sixth Affiliated Hospital of Sun Yet-Sen University , Guangzhou , China and.
authors: Tian-Biao
authors: TB
authors: Zhou
authors: Sheng-Sheng
authors: SS
authors: Yin
authors: Zong-Pei
authors: ZP
authors: Jiang
mesh_terms: D000483:Alleles; D000804:Angiotensin II / Q000235:genetics; D044383:Black People / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II