title: Association between GSTP1 Ile105Val polymorphism and glioma risk: a systematic review and meta-analysis.
abstract: Glutathione S-transferase P1 (GSTP1) gene Ile105Val polymorphism has been suggested to be involved in the development of glioma. However, the results from the studies regarding the association between GSTP1 Ile105Val polymorphism and glioma risk have been inconsistent. Thus, we performed a meta-analysis to investigate this association. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated using random or fixed effects model. Nine studies with 2,078 cases and 3,970 controls were finally included into this meta-analysis. The results suggested there was no association between GSTP1 Ile105Val polymorphism and glioma risk under recessive model (OR = 1.138, 95%CI = 0.966-1.341, Pheterogeneity = 0.088, P = 0.123). Subgroup analyses by ethnicity showed there was also no association between GSTP1 Ile105Val polymorphism and glioma risk in mixed populations under recessive model (OR = 1.199, 95%CI = 0.928-1.549, Pheterogeneity = 0.060, P = 0.166) and Caucasian populations (OR = 1.097, 95%CI = 0.885-1.360, Pheterogeneity = 0.186, P = 0.398). In conclusion, the meta-analysis suggests that there is no association between GSTP1 Ile105Val polymorphism and glioma risk. However, more well-designed and larger studies are needed to further assess this association.
authors: Department of Neurosurgery, General Hospital of Shenyang Military Area Command, Shenyang, 110840, China.
authors: Peng
authors: P
authors: Xie
authors: Yong
authors: Y
authors: Liang
authors: Guobiao
authors: G
authors: Liang
authors: Bing
authors: B
authors: Liu
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001932:Brain Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000208:ethnology / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: D051549:Glutathione S-Transferase pi
references: Eur J Cancer. 2010 Jun;46(9):1617-31
references: 20207535
references: Am J Pharmacogenomics. 2003;3(3):157-72
references: 12814324
references: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):559-65
references: 17372252
references: Nat Genet. 2009 Aug;41(8):899-904
references: 19578367
references: Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):461-7
references: 15006924
references: Eur J Cancer. 2009 May;45(8):1438-42
references: 19157859
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563
references: Hum Mol Genet. 2008 Mar 15;17(6):800-5
references: 18048407
references: Breast Cancer Res Treat. 2011 Jan;125(1):253-9
references: 20526737
references: Curr Opin Genet Dev. 2010 Jun;20(3):239-44
references: 20211558
references: J Clin Epidemiol. 2008 Jul;61(7):634-45
references: 18538260
references: J Neurooncol. 2002 Sep;59(2):123-34
references: 12241105
references: J Toxicol Environ Health B Crit Rev. 2009;12(5-6):389-439
references: 20183528
references: Genet Mol Res. 2010 Mar 23;9(1):539-44
references: 20391338
references: Nat Genet. 2009 Aug;41(8):905-8
references: 19578366
references: Prostate. 2009 May 1;69(6):662-88
references: 19143011
references: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references: 13655060
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Curr Mol Med. 2011 Mar;11(2):129-39
references: 21342130
references: Annu Rev Pharmacol Toxicol. 2005;45:51-88
references: 15822171
references: Mutat Res. 2001 Oct 1;482(1-2):21-6
references: 11535245
references: Genet Mol Res. 2010 Nov 30;9(4):2328-34
references: 21128213
references: Cancer Genet Cytogenet. 2005 Jan 15;156(2):144-9
references: 15642394
references: Pharmacology. 2000 Sep;61(3):154-66
references: 10971201
references: Cancer Epidemiol Biomarkers Prev. 2003 Jan;12(1):14-22
references: 12540498
references: Cancer. 2008 Oct 1;113(7 Suppl):1953-68
references: 18798534
references: Int J Gynecol Cancer. 2010 Jul;20(5):732-7
references: 20966642
references: IARC Sci Publ. 1999;(148):231-49
references: 10493261