title: Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention.
abstract: BACKGROUND
  Elevated lipoprotein(a) [Lp(a)] levels predict cardiovascular events incidence in patients with coronary artery disease (CAD). Genetic variants in the rs3798220, rs10455872 and rs6415084 single-nucleotide polymorphisms (SNPs) in the Lp(a) gene (LPA) correlate with elevated Lp(a) levels, but whether these SNPs have prognostic value for CAD patients is unknown. The present study evaluated the association of LPA SNPs with incidence of subsequent cardiovascular events in CAD patients after percutaneous coronary intervention (PCI).
  
  
  METHODS
  TaqMan SNP genotyping assays were performed to detect the rs6415084, rs3798220 and rs10455872 genotypes in 517 Chinese Han patients with CAD after PCI. We later assessed whether there was an association of these SNPs with incidence of major adverse cardiovascular events (MACE: cardiac death, nonfatal myocardial infarction, ischemic stroke and coronary revascularization). Serum lipid profiles were also determined using biochemical methods.
  
  
  RESULTS
  Only the rs6415084 variant allele was associated with higher Lp(a) levels [41.3 (20.8, 74.6) vs. 18.6 (10.3, 40.9) mg/dl, p < 0.001]. During a 2-year follow-up period, 102 patients suffered MACE, and Cox regression analysis demonstrated that elevated Lp(a) (≥30 mg/dl) levels correlated with increased MACE (adjusted HR, 1.69; 95% CI 1.13-2.53), but there was no association between LPA genetic variants (rs6415084 and rs3798220) and MACE incidence (p > 0.05).
  
  
  CONCLUSIONS
  Our data did not support a relationship between genetic LPA variants (rs6415084 and rs3798220) and subsequent cardiovascular events after PCI in Chinese Han CAD patients.
authors: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong General Hospital, 96 Dongchuan Road, Guangzhou 510007, China. gzghelain@163.com.
authors: Zhi-Gen
authors: ZG
authors: Li
authors: Guang
authors: G
authors: Li
authors: Ying-Ling
authors: YL
authors: Zhou
authors: Zhu-Jun
authors: ZJ
authors: Chen
authors: Jun-Qing
authors: JQ
authors: Yang
authors: Ying
authors: Y
authors: Zhang
authors: Shuo
authors: S
authors: Sun
authors: Shi-Long
authors: SL
authors: Zhong
mesh_terms: D000368:Aged; D044466:Asian People; D003324:Coronary Artery Disease / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000601:surgery; D003643:Death; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000601:surgery
chemical_list: D017270:Lipoprotein(a)
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