title: Clinical implications of the angiosome model in peripheral vascular disease.
abstract: Vascular surgery has seen a revolutionary transformation in its approach to peripheral vascular disease over the last 2 decades, fueled by technological innovation and a willingness by the field to adopt these changes. However, the underlying pathology behind critical limb ischemia and the significant rate of unhealed wounds and secondary amputations despite apparently successful revascularization needs to be addressed. In seeking to improve outcomes, it may be beneficial to examine our approach to vascular disease at the fundamental level of anatomy, the angiosome, to better dictate reperfusion strategies beyond a simple determination of open vs endovascular procedure. We performed a systematic review of the current literature concerning the significance of the angiosome concept in the realm of vascular surgery. The dearth of convincing evidence in the form of prospective trials and large patient populations, and the lack of a consistent, comparable vocabulary to contrast study findings, prevent recommendation of the conceptual model at a wider level for guidance of revascularization attempts. Further well-structured, prospective studies are required as well as emerging imaging strategies, such as indocyanine green dye-based fluorescent angiography or hyperspectral imaging, to allow wider adoption of the angiosome model in vascular operations.
authors: Department of Vascular Surgery, Yale University School of Medicine, New Haven, CT 06510, USA. bauer.sumpio@yale.edu
authors: Bauer E
authors: BE
authors: Sumpio
authors: Rachael O
authors: RO
authors: Forsythe
authors: Kenneth R
authors: KR
authors: Ziegler
authors: Jeff G
authors: JG
authors: van Baal
authors: Mauri J A
authors: MJ
authors: Lepantalo
authors: Robert J
authors: RJ
authors: Hinchliffe
mesh_terms: D003097:Collateral Circulation; D003952:Diagnostic Imaging / Q000379:methods; D005121:Extremities / Q000098:blood supply*; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures