title: Herpes simplex virus type 1 encephalitis and unusual retinitis in a patient with systemic lupus erythematosus.
abstract: In this report we discuss a case of a patient with systemic lupus erythematosus who developed herpes simplex virus type 1(HSV-1) infection presenting with encephalitis as well as necrotic and non-necrotic retinitis. The patient presented with typical clinical symptoms and radiologic abnormalities consistent with HSV-1 encephalitis and HSV-1 retinitis in patients with HIV infection, but lacked cerebrospinal fluid pleocytosis and had bilateral retinitis with poor visual acuity. To the best of our knowledge, this is the first such case reported in the literature.
authors: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, China.
authors: L
authors: L
authors: Zhang
authors: J J
authors: JJ
authors: Liu
authors: M T
authors: MT
authors: Li
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D020803:Encephalitis, Herpes Simplex / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D005260:Female; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D009887:Ophthalmoscopy; D011237:Predictive Value of Tests; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D014792:Visual Acuity
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents
keywords: Herpes simplex virus type 1; encephalitis; necrotic retinitis; non-necrotic retinitis; systemic lupus erythematosus