title: [Hypofractionated radiotherapy in prostate cancer].
abstract: Radiotherapy plays a central role in the management of localized prostate cancer, but the total duration of treatment of nearly 2 months poses not only problems of fatigue related to repetitive transports, especially for older patients, but also increases the overall cost of treatment including linear accelerators occupancy and patient transportation. To address this problem, various teams have developed hypofractionated radiotherapy protocols seeking to maintain the same efficacy and toxicity while reducing the total duration of treatment. These hypofractionated protocols require recent techniques such as image-guided radiation therapy (IGRT) and intensity-modulated radiation therapy (IMRT). Single centre series have validated the feasibility of "light" hypofractionation schemes at doses per fraction less than 6 Gy Similarly, different teams have shown the possibility of stereotactic irradiation for delivering "severe" hypofractionation schemes at doses greater than 6 Gy per fraction. Whatever the dose per fraction, the current clinical data support the conclusion that hypofractionated radiotherapy does not increase mid-term toxicity and could even improve biochemical control. Studies with the objective of demonstrating non-inferiority are expected to definitively validate the role of hypofractionated irradiation in the treatment of prostate cancer.
authors: Département de radiothérapie, institut de cancérologie de l'Ouest Nantes-Angers, boulevard Jacques-Monod, 44805 Saint-Herblain, France. Electronic address: stephane.supiot@ico.unicancer.fr.
authors: S
authors: S
authors: Supiot
authors: G
authors: G
authors: Créhange
authors: I
authors: I
authors: Latorzeff
authors: P
authors: P
authors: Pommier
authors: A
authors: A
authors: Paumier
authors: E
authors: E
authors: Rio
authors: G
authors: G
authors: Delaroche
authors: S
authors: S
authors: Guérif
authors: C
authors: C
authors: Catton
authors: J
authors: J
authors: Martin
authors: A
authors: A
authors: Lisbona
mesh_terms: D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D016634:Radiosurgery; D061089:Radiotherapy, Image-Guided; D050397:Radiotherapy, Intensity-Modulated; D016032:Randomized Controlled Trials as Topic
keywords: Cancer; Fractionnement; Hypofractionation; Hypofractionnement; Prostate; Radiotherapy; Radiothérapie; Stereotactic; Stéréotaxie