title: Correlations between psoriasis and inflammatory bowel diseases.
abstract: For a long time the relationship between inflammatory bowel diseases (IBDs) and psoriasis has been investigated by epidemiological studies. It is only starting from the 1990s that genetic and immunological aspects have been focused on. Psoriasis and IBD are strictly related inflammatory diseases. Skin and bowel represent, at the same time, barrier and connection between the inner and the outer sides of the body. The most important genetic correlations involve the chromosomal loci 6p22, 16q, 1p31, and 5q33 which map several genes involved in innate and adaptive immunity. The genetic background represents the substrate to the common immune processes involved in psoriasis and IBD. In the past, psoriasis and IBD were considered Th1-related disorders. Nowadays the role of new T cells populations has been highlighted. A key role is played by Th17 and T-regs cells as by the balance between these two cells types. New cytokines and T cells populations, as IL-17A, IL-22, and Th22 cells, could play an important pathogenetic role in psoriasis and IBD. The therapeutic overlaps further support the hypothesis of a common pathogenesis.
authors: Department of Dermatology Daniele Innocenzi, A. Fiorini Hospital, Sapienza University of Rome, Terracina, Italy. nevena.skroza@uniroma1.it
authors: Nevena
authors: N
authors: Skroza
authors: Ilaria
authors: I
authors: Proietti
authors: Riccardo
authors: R
authors: Pampena
authors: Giorgio
authors: G
authors: La Viola
authors: Nicoletta
authors: N
authors: Bernardini
authors: Francesca
authors: F
authors: Nicolucci
authors: Ersilia
authors: E
authors: Tolino
authors: Sara
authors: S
authors: Zuber
authors: Valentina
authors: V
authors: Soccodato
authors: Concetta
authors: C
authors: Potenza
mesh_terms: D015897:Comorbidity; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D007422:Intestines / Q000503:physiopathology*; D008954:Models, Biological; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology* / Q000503:physiopathology*; D012307:Risk Factors; D012867:Skin / Q000503:physiopathology*; D013223:Statistics as Topic
chemical_list: D016207:Cytokines
references: J Invest Dermatol. 2008 May;128(5):1325-7
references: 18034172
references: J Allergy Clin Immunol. 2003 Apr;111(4):875-81
references: 12704372
references: Inflamm Bowel Dis. 2007 Feb;13(2):191-9
references: 17206665
references: J Exp Med. 2004 Jan 5;199(1):125-30
references: 14707118
references: Immunology. 2005 Sep;116(1):134-41
references: 16108825
references: Clin Exp Immunol. 2008 Aug;153(2):182-7
references: 18505426
references: Nature. 2006 May 11;441(7090):235-8
references: 16648838
references: Am J Respir Cell Mol Biol. 2001 Sep;25(3):335-40
references: 11588011
references: Cytokine. 2008 Feb;41(2):79-83
references: 18218322
references: Gut. 2002 May;50 Suppl 3:III31-6
references: 11953330
references: Curr Rheumatol Rep. 2007 Dec;9(6):461-7
references: 18177599
references: J Med Genet. 2008 Feb;45(2):114-6
references: 17993580
references: Am J Hum Genet. 2006 May;78(5):827-851
references: 16642438
references: Lupus. 2008 Jan;17(1):34-9
references: 18089681
references: Arthritis Rheum. 1971 May-Jun;14(3):291-318
references: 5562018
references: Nature. 2001 May 31;411(6837):603-6
references: 11385577
references: Science. 2007 Aug 3;317(5838):627-9
references: 17673654
references: Rheumatol Int. 2012 Jul;32(7):1893-900
references: 21448648
references: Clin Immunol. 2007 Dec;125(3):281-90
references: 17897887
references: Arch Dermatol. 1974 Feb;109(2):207-11
references: 4814926
references: Exp Dermatol. 2007 Oct;16(10):779-98
references: 17845210
references: Dermatology. 2006;213(2):111-7
references: 16902287
references: Inflamm Bowel Dis. 2001 Aug;7(3):260-70
references: 11515854
references: Immunity. 2000 Nov;13(5):715-25
references: 11114383
references: Gut. 1999 Apr;44(4):519-26
references: 10075959
references: J Eur Acad Dermatol Venereol. 2009 May;23(5):561-5
references: 19207663
references: Gastroenterology. 2003 Feb;124(2):521-36
references: 12557156
references: Gut. 1968 Feb;9(1):17-21
references: 5640920
references: Hum Mol Genet. 1997 Aug;6(8):1349-56
references: 9259283
references: Nat Med. 2007 Feb;13(2):139-45
references: 17290272
references: Hum Genet. 2007 Sep;122(2):201-6
references: 17587057
references: Nat Immunol. 2008 Jun;9(6):641-9
references: 18454151
references: J Invest Dermatol. 2006 Apr;126(4):740-5
references: 16439971
references: Am J Hum Genet. 2007 Feb;80(2):273-90
references: 17236132
references: Eur J Immunol. 2006 May;36(5):1309-23
references: 16619290
references: J Immunol. 2006 Oct 1;177(7):4488-94
references: 16982885
references: Gut. 2003 Jan;52(1):65-70
references: 12477762
references: J Immunol. 2000 Dec 1;165(11):6107-15
references: 11086043
references: Diabetes. 2005 Jan;54(1):92-9
references: 15616015
references: J Dermatol. 1997 Apr;24(4):275-6
references: 9164074
references: J Cell Physiol. 2007 Jun;211(3):590-7
references: 17311282
references: Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii87-90
references: 17934104
references: J Dermatolog Treat. 2008;19(5):259-66
references: 18629676
references: J Exp Med. 2004 Aug 2;200(3):277-85
references: 15280421
references: Am J Hum Genet. 2002 Apr;70(4):845-57
references: 11875755
references: Nature. 2007 Jun 7;447(7145):661-78
references: 17554300
references: Indian J Dermatol. 2010 Apr-Jun;55(2):151-6
references: 20606885
references: Clin Dermatol. 2007 Nov-Dec;25(6):529-34
references: 18021889
references: Am J Gastroenterol. 1990 Aug;85(8):962-3
references: 2375323
references: J Invest Dermatol. 2006 May;126(5):998-1002
references: 16484987
references: Hum Mol Genet. 2008 Oct 1;17(19):2978-85
references: 18614543
references: Nature. 2007 Jul 26;448(7152):484-487
references: 17581588
references: Pharmacogenomics J. 2001;1(4):272-87
references: 11911124
references: J Immunol. 2008 Sep 1;181(5):3137-47
references: 18713984
references: J Infect Dis. 2004 Aug 1;190(3):624-31
references: 15243941
references: Immunity. 2008 Apr;28(4):454-67
references: 18400188
references: Nat Immunol. 2004 Aug;5(8):800-8
references: 15220916
references: J Am Acad Dermatol. 2003 Jun;48(6):805-21; quiz 822-4
references: 12789169
references: Gastroenterology. 2005 Sep;129(3):827-36
references: 16143122
references: Curr Opin Immunol. 2007 Jun;19(3):281-6
references: 17433650
references: Genes Immun. 2008 Mar;9(2):176-81
references: 18075513
references: Mt Sinai J Med. 1999 May;66(3):206
references: 10377554
references: J Invest Dermatol. 2001 Dec;117(6):1671-2
references: 11886540
references: J Invest Dermatol. 2008 Jul;128(7):1653-61
references: 18219280
references: Am J Gastroenterol. 1991 Jun;86(6):787-8
references: 2039010
references: Nat Rev Immunol. 2003 May;3(5):371-82
references: 12766759
references: J Microbiol Immunol Infect. 2008 Feb;41(1):78-87
references: 18327431
references: Science. 2007 Jun 1;316(5829):1336-41
references: 17463249