title: Peer attachment formation by systemic redox regulation with social training after a sensitive period.
abstract: Attachment formation is the most pivotal factor for humans and animals in the growth and development of social relationships. However, the developmental processes of attachment formation mediated by sensory-motor, emotional, and cognitive integration remain obscure. Here we developed an animal model to understand the types of social interactions that lead to peer-social attachment formation. We found that the social interaction in a sensitive period was essential to stabilise or overwrite the initially imprinted peer affiliation state and that synchronised behaviour with others based on common motivations could be a driver of peer social attachment formation. Furthermore, feeding experience with supplementation of ubiquinol conferred peer social attachment formation even after the sensitive period. Surprisingly, the experience of feeding beyond the cage window was also effective to reduce the required amount ubiquinol, suggesting that peri-personal space modulation may affect socio-emotional cognition and there by lead to attachment formation.
authors: 1] National Institute of Neuroscience, NCNP, Tokyo, Japan [2] Tokyo University of Agriculture and Technology, Life Science and Biotechnology, Tokyo, Japan [3] Saitama Medical University, Saitama, Japan.
authors: Mamiko
authors: M
authors: Koshiba
authors: Genta
authors: G
authors: Karino
authors: Aya
authors: A
authors: Senoo
authors: Koki
authors: K
authors: Mimura
authors: Yuka
authors: Y
authors: Shirakawa
authors: Yuta
authors: Y
authors: Fukushima
authors: Saya
authors: S
authors: Obara
authors: Hitomi
authors: H
authors: Sekihara
authors: Shimpei
authors: S
authors: Ozawa
authors: Kentaro
authors: K
authors: Ikegami
authors: Toyotoshi
authors: T
authors: Ueda
authors: Hideo
authors: H
authors: Yamanouchi
authors: Shun
authors: S
authors: Nakamura
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D019587:Dietary Supplements; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D007398:Interpersonal Relations; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D009769:Object Attachment; D010084:Oxidation-Reduction / Q000187:drug effects; D010379:Peer Group; D012919:Social Behavior; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014451:Ubiquinone; C003741:ubiquinol
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