title: Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives.
abstract: A number of isoindole (3x, 3y, 6xa-6ye), pyrrolopyrazine (3z, 6za-6ze), benzimidazoisoindole (4x, 4y, 7xa-7ye), and benzimidazopyrrolopyrazine (4z, 7za-7ze) derivatives has been synthesized in excellent yields. All these compounds were fully characterized and evaluated against five human cancer cell lines for their anti-inflammatory and antiproliferative activity. Compounds 6yc and 7zd exhibited good anti-inflammatory activity whereas compounds 6zc, 7zd (lung NCl H-522), 6ye, 7xd, 7yd, 7zc, 7zd (colon HCT-15), 6xc, 7zc (ovary PA-1), 6xc, 6yb, 6zc (liver HepG-2) exhibited good antiproliferative activity.
authors: Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee , 247667, UK, India.
authors: Sandeep
authors: S
authors: Kumar
authors: Nikhil
authors: N
authors: Kumar
authors: Partha
authors: P
authors: Roy
authors: Sham M
authors: SM
authors: Sondhi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D054833:Isoindoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D054833:Isoindoles
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