title: Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement.
abstract: BACKGROUND
  Femoroacetabular impingement (FAI) is one of the most common causes of early cartilage and labral damage in the nondysplastic hip. Biomarkers of cartilage degradation and inflammation are associated with osteoarthritis. It was not known whether patients with FAI have elevated levels of biomarkers of cartilage degradation and inflammation.
  
  
  OBJECTIVE
  Compared with athletes without FAI, athletes with FAI would have elevated levels of the inflammatory C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP), a cartilage degradation marker.
  
  
  METHODS
  Controlled laboratory study.
  
  
  METHODS
  Male athletes with radiographically confirmed FAI (n = 10) were compared with male athletes with radiographically normal hips with no evidence of FAI or hip dysplasia (n = 19). Plasma levels of COMP and CRP were measured, and subjects also completed the Short Form-12 (SF-12) and Hip Disability and Osteoarthritis Outcome Score (HOOS) surveys.
  
  
  RESULTS
  Compared with controls, athletes with FAI had a 24% increase in COMP levels and a 276% increase in CRP levels as well as a 22% decrease in SF-12 physical component scores and decreases in all of the HOOS subscale scores.
  
  
  CONCLUSIONS
  Athletes with FAI demonstrate early biochemical signs of increased cartilage turnover and systemic inflammation.
  
  
  CONCLUSIONS
  Chondral injury secondary to the repetitive microtrauma of FAI might be reliably detected with biomarkers. In the future, these biomarkers might be used as screening tools to identify at-risk patients and assess the efficacy of therapeutic interventions such as hip preservation surgery in altering the natural history and progression to osteoarthritis.
authors: Asheesh Bedi, Department of Orthopaedic Surgery, University of Michigan Medical School, 24 Frank Lloyd Wright Drive, Lobby A, Ann Arbor, MI 48106. abedi@umich.edu.
authors: Asheesh
authors: A
authors: Bedi
authors: Evan B
authors: EB
authors: Lynch
authors: Elizabeth R
authors: ER
authors: Sibilsky Enselman
authors: Max E
authors: ME
authors: Davis
authors: Paul D
authors: PD
authors: Dewolf
authors: Tarek A
authors: TA
authors: Makki
authors: Bryan T
authors: BT
authors: Kelly
authors: Christopher M
authors: CM
authors: Larson
authors: Phillip T
authors: PT
authors: Henning
authors: Christopher L
authors: CL
authors: Mendias
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood*; D002358:Cartilage, Articular / Q000378:metabolism; D016022:Case-Control Studies; D057925:Femoracetabular Impingement / Q000097:blood*; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D064236:Cartilage Oligomeric Matrix Protein; C577553:TSP5 protein, human
keywords: C-reactive protein; HOOS; SF-12; cartilage oligomeric matrix protein; osteoarthritis
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