title: Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis.
abstract: BACKGROUND
  A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP).
  
  
  OBJECTIVE
  The purpose of this study was to explore whether there is an association between MS and DBP.
  
  
  METHODS
  We compared DBP concentrations in blood samples of controls (n = 30) and subjects with relapsing-remitting MS (RRMS) during remission (n = 29) and relapse (n = 15). Furthermore, we explored correlations of DBP with 25- hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)2D), and the effect of high-dose vitamin D3 supplementation on DBP levels in RRMS patients (n = 15).
  
  
  RESULTS
  DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. Upon supplementation of high doses vitamin D3, DBP concentration remained unaltered. After supplementation, serum 1,25(OH)2D(R = 0.517, p = 0.049), but not 25(OH)D, correlated positively with DBP.
  
  
  CONCLUSIONS
  We found no association between DBP, MS, and vitamin D status within the physiological range. After high-dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.
authors: Neuroimmunology Research Group, Netherlands Institute for Neuroscience, The Netherlands.
authors: Joost
authors: J
authors: Smolders
authors: Evelyn
authors: E
authors: Peelen
authors: Mariëlle
authors: M
authors: Thewissen
authors: Paul
authors: P
authors: Menheere
authors: Jan
authors: J
authors: Damoiseaux
authors: Raymond
authors: R
authors: Hupperts
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood*; D012008:Recurrence; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014809:Vitamin D-Binding Protein / Q000097:blood*
chemical_list: D014809:Vitamin D-Binding Protein; D014807:Vitamin D
keywords: Multiple sclerosis; vitamin D; vitamin D binding protein