title: Morular endometrial metaplasia: review of the literature and proposal of the management.
abstract: OBJECTIVE
  Morular endometrial metaplasia is a rare condition that can be often misdiagnosed and overtreated, because it can be mistaken for a malignant disease. The aim of this review was to update the current opinion on the significance of this pathology and its risk for potential malignancies.
  
  
  METHODS
  The authors report their experience of two cases of morular metaplasia involving very young women managed conservatively with hysteroscopic resection of the affected areas.
  
  
  RESULTS
  Hysteroscopic resection of these lesions can be an adequate and fertility-sparing treatment of morular metaplasia in women of childbearing age.
  
  
  CONCLUSIONS
  Morular metaplasia has indeed a mutational origin but it is a benign and hormonally inert condition. The risk to develop cancer is closely associated with premalignant or malignant endometrioid glandular proliferations that are often associated with hysthological finding of morules rather than with morules themselves. Management of this condition requires trained pathologists and gynecologists and should be adapted to the age of the patient.
authors: Department of Women's and Children's Health, Obstetrics and Gynecology Clinic, University of Padua, Padua, Italy. pietro.litta@unipd.it
authors: P
authors: P
authors: Litta
authors: A
authors: A
authors: Codroma
authors: G
authors: G
authors: D'Agostino
authors: E
authors: E
authors: Breda
mesh_terms: D000071616:CDX2 Transcription Factor; D016889:Endometrial Neoplasms / Q000209:etiology; D004717:Endometrium / Q000473:pathology*; D005260:Female; D018398:Homeodomain Proteins / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D008679:Metaplasia; D015260:Neprilysin / Q000032:analysis
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; D015260:Neprilysin