title: A systematic review of proton-pump inhibitor therapy for laryngopharyngeal reflux.
abstract: The author performed a MEDLINE literature search to identify and evaluate all randomized, placebo-controlled trials of the treatment of laryngopharyngeal reflux (LPR) with an oral proton-pump inhibitor (PPI) that have been published since 1966. Eight such trials that included a total of 358 patients were identified. These eight studies contained seven different definitions of LPR. Validity scores (maximum: 9) ranged from 5 to 9 (mean: 7.5). One study investigated low-dose once-daily therapy, two studies investigated low-dose twice-daily therapy, and five studies investigated high-dose twice-daily therapy. Outcomes measures were not consistent among studies, and most studies used unvalidated outcomes measures. Only two studies found that a PPI was significantly better than placebo-one in the low-dose twice-daily group and one in the high-dose twice-daily group. The author concludes that the current body of literature is insufficient to draw reliable conclusions about the efficacy of PPI therapy for the treatment of LPR.
authors: Department of Otolaryngology, Queens Hospital Center, 82-68 164th St., Jamaica, NY 11432, USA. megwaluu@yahoo.com
authors: Uchechukwu C
authors: UC
authors: Megwalu
mesh_terms: D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D054328:Proton Pump Inhibitors