title: Single nucleotide polymorphisms of PIN1 promoter region and cancer risk: evidence from a meta-analysis.
abstract: BACKGROUND
  Peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1) is involved in the process of tumorigenesis. The two single nucleotide polymorphisms (-677T>C, -842G>C) in the PIN1 promoter region have been suspected of being associated with cancer risk for years, but the conclusion is still inconclusive.
  
  
  METHODS
  Eligible case-control studies were retrieved by searching databases and references of related reviews and studies. Genotype distribution data, adjusted odds ratios (ORs) and 95% confidence (CIs) intervals were extracted to calculate pooled ORs.
  
  
  RESULTS
  A total of 4619 cancer cases and 4661 controls were included in this meta-analysis. Overall, the PIN1 -667T>C polymorphism was not associated with cancer risk, while the -842C allele was significantly associated with reduced cancer risk (CC+GC vs. GG, OR = 0.725, 95% CI: 0.607-0.865; P(heterogeneity) = 0.012 and GC vs. GG: OR = 0.721, 95% CI: 0.591-0.880; P(heterogeneity) = 0.003). Results from genotype distribution data were in agreement with those calculated with adjusted ORs and 95% CIs. No publication bias was detected.
  
  
  CONCLUSIONS
  Results of this meta-analysis suggest that the PIN1 -842G>C polymorphism is associated with decreased cancer risk, but that the -667T>C polymorphism is not.
authors: Department of Oncology, the General Hospital of Chengdu Military District, Chengdu, Sichuan, P.R. China.
authors: Jing-Jing
authors: JJ
authors: Peng
authors: Dong
authors: D
authors: Wei
authors: Dong
authors: D
authors: Li
authors: Zeng-Qiang
authors: ZQ
authors: Fu
authors: Yong
authors: Y
authors: Tan
authors: Tao
authors: T
authors: Xu
authors: Jing-Jun
authors: JJ
authors: Zhou
authors: Tao
authors: T
authors: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D019696:Peptidylprolyl Isomerase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk; D044465:White People
chemical_list: D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase
references: EMBO J. 2001 Jul 2;20(13):3459-72
references: 11432833
references: Oncol Rep. 2003 Mar-Apr;10(2):455-61
references: 12579289
references: Gastroenterology. 2007 Jun;132(7):2618-9; author reply 2619-20
references: 17570241
references: Hum Mutat. 2011 Nov;32(11):1299-308
references: 21850685
references: Nat Cell Biol. 2005 May;7(5):435-41
references: 15867923
references: Cancer Cell. 2003 Sep;4(3):175-80
references: 14522251
references: Psychol Methods. 2003 Sep;8(3):243-53
references: 14596489
references: Mol Cancer. 2008 Dec 15;7:91
references: 19077306
references: Cell. 1997 Jun 13;89(6):875-86
references: 9200606
references: Neurobiol Aging. 2007 Jan;28(1):69-74
references: 16384626
references: Mol Biol Rep. 2013 Feb;40(2):829-38
references: 23054026
references: Carcinogenesis. 2009 Oct;30(10):1717-21
references: 19625347
references: PLoS Med. 2006 Apr;3(4):e91
references: 16509765
references: Cancer Res. 2003 Oct 1;63(19):6244-51
references: 14559810
references: Nat Cell Biol. 2001 Sep;3(9):793-801
references: 11533658
references: Control Clin Trials. 1986 Sep;7(3):177-88
references: 3802833
references: Breast Cancer Res Treat. 2010 Jul;122(1):243-9
references: 20033770
references: Neurosci Lett. 2013 Feb 22;535:100-3
references: 23274710
references: J Cell Sci. 2003 Mar 1;116(Pt 5):773-83
references: 12571275
references: Nature. 1996 Apr 11;380(6574):544-7
references: 8606777
references: Scand J Clin Lab Invest. 2011 Oct;71(6):500-6
references: 21745146
references: Neurosci Lett. 2006 Jul 24;402(3):259-61
references: 16701948
references: Cell Mol Life Sci. 1999 Nov 30;56(9-10):788-806
references: 11212339
references: Mol Biol Rep. 2013 May;40(5):3777-82
references: 23269625
references: PLoS One. 2013;8(2):e57246
references: 23460834
references: Neoplasia. 2001 Nov-Dec;3(6):550-9
references: 11774038
references: BMJ. 1997 Sep 13;315(7109):629-34
references: 9310563