title: Combination of percutaneous radiofrequency ablation and systemic chemotherapy are effective treatment modalities for metachronous liver metastases from gastric cancer.
abstract: This study evaluated the efficacy of percutaneous radiofrequency ablation (RFA) for the treatment of metachronous liver metastases of gastric cancer. We enrolled a total of 44 patients who underwent percutaneous RFA for the treatment of metachronous liver metastases after resection of a primary gastric adenocarcinoma from January 2002 to November 2011. The primary endpoint of this study was overall survival (OS) and recurrence-free survival (RFS) after RFA. Systemic chemotherapy was combined with RFA in 40 patients; the OS and RFS of the patients with liver-only metastasis who underwent RFA and chemotherapy were 20.9 months (95% CI 18.4-23.4) and 9.8 months (95% CI 9.2-10.5), respectively. On multivariate analysis, the factors independently, negatively associated with OS were extrahepatic metastatic lesions (HR 12.6, 95% CI 3.7-42.9; p=0.001), no chemotherapy (HR 43.3, 95% CI 7.4-251.3; p=0.001), and tumor number≥2 (HR 2.6, 95% CI 1.2-5.9; p=0.015). The factors independently, negatively associated with RFS were extrahepatic metastatic lesions (HR 3.6, 95% CI 1.6-7.8; p=0.003) and bilobar intrahepatic distribution (HR 3.9, 95% CI 1.5-9.9; p=0.001). The efficacy of percutaneous RFA for metachronous liver metastases of gastric cancer is limited to patients with a single, unilobar metastasis without extrahepatic metastatic lesions. Combined systemic chemotherapy is very important for the prolongation of OS.
authors: Department of Hematology and Oncology, Chonnam National University Hwasun Hospital and Medical School, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam, Kwangju, 519-763, Korea.
authors: Jun-Eul
authors: JE
authors: Hwang
authors: Seung-Hun
authors: SH
authors: Kim
authors: Joon
authors: J
authors: Jin
authors: Ji-Yun
authors: JY
authors: Hong
authors: Min-Jee
authors: MJ
authors: Kim
authors: Sung-Hoon
authors: SH
authors: Jung
authors: Hyun-Jeong
authors: HJ
authors: Shim
authors: Woo-kyun
authors: WK
authors: Bae
authors: Eu-Chang
authors: EC
authors: Hwang
authors: Jin-Woong
authors: JW
authors: Kim
authors: Sang-Soo
authors: SS
authors: Shin
authors: Oh
authors: O
authors: Jeong
authors: Young Kyu
authors: YK
authors: Park
authors: Sang-Hee
authors: SH
authors: Cho
authors: Ik-Joo
authors: IJ
authors: Chung
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D017115:Catheter Ablation / Q000379:methods; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*
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