title: Difference in outcomes between living left lobe donors and noncirrhotic subjects undergoing left lobe resections.
abstract: OBJECTIVE
  The aim of this study was to compare short- and long-term outcomes between the living donors and patients without cirrhosis after left lobe resection.
  
  
  METHODS
  We retrospectively collected data from 40 left lobe donors (Group 1) and from 40 patients who had undergone left liver resection for various diseases (Group 2) from 2002 to 2010. In addition to preoperative parameters, we compared intraoperative variables as well as, short- and long-term outcomes, including postoperative complications and laboratory test results. The liver functions included total bilurubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), international normalized ratio (INR), and albumin (ALB) compared as well as changes in white blood cell (WBC) count and platelet count.
  
  
  RESULTS
  The preoperative parameters of the two groups were comparable. There was significantly more blood loss in Group 2 than Group 1 (422.5 mL vs 318.8 mL; P = .001), leading to more autologous blood transfusions in Group 2 (P = .008). The other intraoperative variables were similar between the two groups. The overall postoperative complication rate was similar: 4% in Group 1 and 8% in Group 2 (P = .213); however, there were longer hospital stays and overall costs in Group 1 (P < .05). The total bilirubin level, AST, and ALT of Group 2 were worse than those in Group 1 during the early postoperative period. Upon long-term follow-up the postoperative platelet count decreased in the two groups compared with the preoperative levels.
  
  
  CONCLUSIONS
  The type and rate of complications following left hepatectomy were similar between donors and noncirrhotic hepatic patients. Nevertheless, more serious liver dysfunction postoperatively was observed among the patient group.
authors: Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, China.
authors: J
authors: J
authors: Lei
authors: L
authors: L
authors: Yan
authors: W
authors: W
authors: Wang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000191:economics; D017721:Hospital Costs; D006801:Humans; D019934:International Normalized Ratio; D007902:Length of Stay; D007958:Leukocyte Count; D008107:Liver Diseases / Q000175:diagnosis / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D019520:Living Donors; D008297:Male; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers