title: Real-timein vivocomputed optical interferometric tomography.
abstract: High-resolution real-time tomography of scattering tissues is important for many areas of medicine and biology1-6. However, the compromise between transverse resolution and depth-of-field in addition to low sensitivity deep in tissue continue to impede progress towards cellular-level volumetric tomography. Computed imaging has the potential to solve these long-standing limitations. Interferometric synthetic aperture microscopy (ISAM)7-9is a computed imaging technique enabling high-resolution volumetric tomography with spatially invariant resolution. However, its potential for clinical diagnostics remains largely untapped since full volume reconstructions required lengthy postprocessing, and the phase-stability requirements have been difficult to satisfyin vivo. Here we demonstrate how 3-D Fourier-domain resampling, in combination with high-speed optical coherence tomography (OCT), can achieve high-resolutionin vivotomography. Enhanced depth sensitivity was achieved over a depth-of-field extended in real time by more than an order of magnitude. This work lays the foundation for high-speed volumetric cellular-level tomography.
authors: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign.
authors: Adeel
authors: A
authors: Ahmad
authors: Nathan D
authors: ND
authors: Shemonski
authors: Steven G
authors: SG
authors: Adie
authors: Hee-Seok
authors: HS
authors: Kim
authors: Wen-Mei W
authors: WM
authors: Hwu
authors: P Scott
authors: PS
authors: Carney
authors: Stephen A
authors: SA
authors: Boppart
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