title: A hybrid ring-opening metathesis polymerization catalyst based on an engineered variant of the β-barrel protein FhuA.
abstract: A β-barrel protein hybrid catalyst was prepared by covalently anchoring a Grubbs-Hoveyda type olefin metathesis catalyst at a single accessible cysteine amino acid in the barrel interior of a variant of β-barrel transmembrane protein ferric hydroxamate uptake protein component A (FhuA). Activity of this hybrid catalyst type was demonstrated by ring-opening metathesis polymerization of a 7-oxanorbornene derivative in aqueous solution.
authors: Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52056 Aachen (Germany).
authors: Freddi
authors: F
authors: Philippart
authors: Marcus
authors: M
authors: Arlt
authors: Steve
authors: S
authors: Gotzen
authors: Stefanie-Joana
authors: SJ
authors: Tenne
authors: Marco
authors: M
authors: Bocola
authors: Hsui-Hui
authors: HH
authors: Chen
authors: Leilei
authors: L
authors: Zhu
authors: Ulrich
authors: U
authors: Schwaneberg
authors: Jun
authors: J
authors: Okuda
mesh_terms: D000475:Alkenes / Q000737:chemistry; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D002384:Catalysis; D029968:Escherichia coli Proteins / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry*; D058105:Polymerization
chemical_list: D000475:Alkenes; D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; C050900:FhuA protein, E coli; D009636:Norbornanes
keywords: biocatalysis; metalloproteins; protein engineering; ring-opening polymerization; ruthenium