title: [A case of simultaneously occurred amiodarone-induced hepatitis and hypothyroidism].
abstract: Amiodarone is a di-iodated benzofuran derivative that is commonly used to treat patients with various cardiac arrhythmias. It is associated with side effects that involve the liver, thyroid, and other organs. Approximately 1-3% of patients treated with amiodarone suffer from symptomatic liver disease. Thyroid dysfunction occurs in 10% of patients treated with amiodarone. A 65-year-old woman with coronary heart disease and atrial fibrillation was administered with amiodarone. She developed nausea, vomiting, dyspepsia, and sweating within 9 months of amiodarone administration (200 mg orally once a day). Results of the laboratory finding showed increased hepatic enzymes, and low thyroid hormone levels. A liver biopsy showed irregular arrangement of hepatocytes and diffuse micro- and macrovesicular fatty changes. Electron microscopy findings showed pleomorphic mitochondria with crystalloid inclusions and membrane-bound lysosomal structures. The liver and thyroid functions returned to normal, after the amiodarone was stopped. We describe an unusual case in which amiodarone induced hepatitis and hypothyroidism simultaneously. Physicians should take a close look to the adverse event when using amiodarone which can cause adverse effects in multiple organs.
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
authors: Young Shim
authors: YS
authors: Cho
authors: Joung Ho
authors: JH
authors: Han
authors: Hee Bok
authors: HB
authors: Chae
authors: Jae Su
authors: JS
authors: Kim
authors: Ky Man
authors: KM
authors: Kang
authors: Sang Min
authors: SM
authors: Park
authors: Jun Cheol
authors: JC
authors: Lim
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000150:complications*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000638:Amiodarone