title: Small azobenzene derivatives active against bacteria and fungi.
abstract: ATP synthase and protein kinase (PKs) are prime targets for drug discovery in a variety of diseases. It is well known that numerous stilbenes are capable to interact and inhibit ATP synthase and PKs. This work focuses on a series of azobenzene based molecules having high structural similarity with antimicrobial stilbenes. An investigation was carried out analyzing the potential toxicity of a large set of molecules by means of computational analysis. A small selection of potential low toxic molecules have been therefore synthesized, characterized and finally microbiologically tested. The synthesized compounds show potent bactericidal activity against Gram+ and a fungus, and are capable of inhibiting biofilm formation. Finally, the compounds demonstrated a thermal stability that makes them potential candidates for incorporation in polymer matrix for application as biomedical devices and food packaging.
authors: Department of Pharmacy, University of Salerno, via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy.
authors: Stefano
authors: S
authors: Piotto
authors: Simona
authors: S
authors: Concilio
authors: Lucia
authors: L
authors: Sessa
authors: Amalia
authors: A
authors: Porta
authors: Elena Concetta
authors: EC
authors: Calabrese
authors: Anna
authors: A
authors: Zanfardino
authors: Mario
authors: M
authors: Varcamonti
authors: Pio
authors: P
authors: Iannelli
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001391:Azo Compounds / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D003198:Computer Simulation; D055808:Drug Discovery; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001391:Azo Compounds; D013267:Stilbenes; C009850:azobenzene
keywords: ADMET; Antimicrobial; Azobenzenes