title: Synthesis and anti-inflammatory activity of aromatic glucosinolates.
abstract: Aromatic GLs are important members of the glucosinolate family of compounds because of their potential biological activity and medicinal properties. This study has shown success in the high yielding synthesis of some important aromatic GLs as well as the results of testing for anti-inflammatory properties of the synthetic GLs. 3,4-Dimethoxyphenylglucosinolate was found to be the most active anti-inflammatory of the seven glucosinolates assayed.
authors: Department of Chemistry, La Trobe University, Victoria 3086, Australia.
authors: Quan V
authors: QV
authors: Vo
authors: Craige
authors: C
authors: Trenerry
authors: Simone
authors: S
authors: Rochfort
authors: Jenny
authors: J
authors: Wadeson
authors: Carolina
authors: C
authors: Leyton
authors: Andrew B
authors: AB
authors: Hughes
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002460:Cell Line; D005961:Glucosinolates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure
chemical_list: C587535:3,4-dimethoxyphenylglucosinolate; D000893:Anti-Inflammatory Agents; D005961:Glucosinolates
keywords: 1,2-dimethoxyethane; 3,4-Dimethoxyphenylglucosinolate; Anti-inflammatory; Aromatic glucosinolate; Brassica; DCM; DME; DMF; ELISA; ESI; FTMS; GLs; HESI; HRMS; IR; LPS; MS; N,N-dimethylformamide; N-chlorosuccinimide; NCS; NMR; PMA; THF; TLC; TNF-α; TNFalpha; UV; Z; benzyloxycarbonyl; dichloromethane; electrospray ionization; enzyme-linked immunosorbent assay; fourier transform mass spectrometry; glucosinolates; heated electrospray ionization; high resolution mass spectrometry; infra-red; lipopolysaccharides; mass spectrometry; nuclear magnetic resonance; phorbol-12-myristate-13-acetate; tetrahydrofuran; thin layer chromatography; tumor necrosis factor alpha; ultra-violet