title: Roles of renal proximal tubule transport in the pathogenesis of hypertension.
abstract: Hypertension is a key factor of cardiovascular disease. Many organs and systems including heart, blood vessel, kidney, sympathetic nerve, and endocrine systems are involved in the regulation of blood pressure. In particular, the kidney plays an essential role in the regulation of blood pressure, but is also quite vulnerable to hypertensive tissue damage. For example, most chronic kidney disease (CKD) patients have hypertension and are revealed to have higher mortality than normal population. Furthermore, hypertensive renal sclerosis is emerging as the third main cause of dialysis patients. This mini review is to summarize the effects of angiotensin II and dopamine on renal proximal tubule transport, which may have important roles in the regulation of blood pressure.
authors: Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8655, Japan.
authors: Shoko
authors: S
authors: Horita
authors: George
authors: G
authors: Seki
authors: Hideomi
authors: H
authors: Yamada
authors: Masashi
authors: M
authors: Suzuki
authors: Kazuhiko
authors: K
authors: Koike
authors: Toshiro
authors: T
authors: Fujita
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000502:physiology*; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D044140:Receptor, Angiotensin, Type 1; D004298:Dopamine