title: Association of polymorphisms in TRAIL1 and TRAILR1 genes with susceptibility to lymphomas.
abstract: The TRAILR1/TRAIL system is implicated in the induction of the extrinsic apoptotic pathway and constitutes an emerging target in cancer therapeutics. The objective of this study is to assess lymphoma risk associated with certain polymorphisms in TRAILR1 and TRAIL1 genes. DNA was extracted from 381 subjects (190 lymphoma cases and 191 matched controls) and genotyped for polymorphisms rs20576, rs2230229 and rs20575 in TRAILR1 and rs12488654 in TRAIL gene. In contrast to TRAILR1 polymorphisms, the genotype distribution of rs12488654 in TRAIL gene was different between cases and controls, A allele carriers (CA/AA) being much more common in the cases with different lymphoma types (follicular, 45 %; diffuse large B cell, 45.2 % and Hodgkin lymphomas, 40 %) than in controls (15.7 %) (odds ratio (OR), 3.5; CI, 2.1–5.9; p<0.001; OR, 3.5; CI, 1.6–7.9; p=0.001; OR, 2.9; CI, 1.1–7.5; p=0.027, respectively). This effect was consistently independent of the association with the TRAILR1 polymorphisms studied, as demonstrated by linkage disequilibrium and haplotype analyses. This study is the first one to report an association between a TRAIL polymorphism and lymphoma risk and suggests a possible role of TRAIL in B cell lymphomagenesis.
authors: Beatriz
authors: B
authors: Heredia-Galvez
authors: Javier
authors: J
authors: Ruiz-Cosano
authors: Daniel
authors: D
authors: Torres-Moreno
authors: Ignacio
authors: I
authors: Español
authors: María José
authors: MJ
authors: Morales-Lara
authors: Elena
authors: E
authors: Pérez-Ceballos
authors: Rocío
authors: R
authors: González-Conejero
authors: Rocío
authors: R
authors: Gutiérrez-Cívicos
authors: Vicente
authors: V
authors: Vicente
authors: Miguel
authors: M
authors: Pérez-Guillermo
authors: Pablo
authors: P
authors: Conesa-Zamora
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics* / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics* / Q000378:metabolism
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human