title: Genetic polymorphisms of pharmacogenomic VIP variants in the Kyrgyz population from northwest China.
abstract: Pharmacogenomic variant information is well known for major human populations; however, this information is less commonly studied in minorities. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Kyrgyz population and compared our data with other four major human populations including Han Chinese in Beijing, China (CHB), the Japanese in Tokyo, Japan (JPT), a northern and western Europe population (CEU), and the Yoruba in Ibadan, Nigeria (YRI). There were 13, 12 and 16 of the selected VIP variant genotype frequencies in the Kyrgyz which differed from those of the CHB, JPT and CEU, respectively (p<0.005). In the YRI, there were 32 different variants, compared to the Kyrgyz (p<0.005). Genotype frequencies of ADH1B, AHR, CYP3A5, PTGS2, VDR, and VKORC1 in the Kyrgyz differed widely from those in the four populations. Haplotype analyses also showed differences among the Kyrgyz and the other four populations. Our results complement the information provided by the database of pharmacogenomics on Kyrgyz. We provide a theoretical basis for safer drug administration and individualized treatment plans for the Kyrgyz. We also provide a template for the study of pharmacogenomics in various ethnic minority groups in China.
authors: School of Life Sciences, Northwest University, Xi'an 710069, China; National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China; College of Life Sciences and Technology, Xinjiang University, Urumqi 830046, China.
authors: Zulfiya
authors: Z
authors: Yunus
authors: Lijun
authors: L
authors: Liu
authors: Hong
authors: H
authors: Wang
authors: Le
authors: L
authors: Zhang
authors: Xiaolan
authors: X
authors: Li
authors: Tingting
authors: T
authors: Geng
authors: Longli
authors: L
authors: Kang
authors: Tianbo
authors: T
authors: Jin
authors: Chao
authors: C
authors: Chen
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D002681:China / Q000208:ethnology; D051546:Cyclooxygenase 2 / Q000235:genetics; D051544:Cytochrome P-450 CYP3A / Q000235:genetics; D005060:Europe / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D006239:Haplotypes; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000235:genetics; D009549:Nigeria / Q000208:ethnology; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics; D014041:Tokyo / Q000208:ethnology; D064417:Vitamin K Epoxide Reductases
chemical_list: D000426:Alcohol Dehydrogenase; D051792:Basic Helix-Loop-Helix Proteins; D051546:Cyclooxygenase 2; D051544:Cytochrome P-450 CYP3A; D006899:Mixed Function Oxygenases; D018336:Receptors, Aryl Hydrocarbon; D018167:Receptors, Calcitriol; D064417:Vitamin K Epoxide Reductases; C111235:AHR protein, human; C579457:VDR protein, human; C489332:ADH1B protein, human; C510164:CYP3A5 protein, human; C496540:PTGS2 protein, human; C578523:VKORC1 protein, human
keywords: CEU; CHB; Genetic polymorphism; HWE; Han Chinese in Beijing China; Haplotype; Hardy–Weinberg Equilibrium; JPT; Kyrgyz; LD; Pharmacogenomics; SNP; VIP variants; YRI; a northern and western Europe population; linkage disequilibrium; single nucleotide polymorphism; the Japanese in Tokyo Japan; the Yoruba in Ibadan Nigeria; very important pharmacogenetic variants