title: Discovery of the cellular and molecular basis of cholesterol control.
abstract: The cellular control of cholesterol metabolism mediated by lipoproteins was first appreciated in pioneering work published in a 1974 PNAS Classic by Michael Brown and Joseph Goldstein. We know from this paper that the LDL binds to a cell surface receptor and dampens the activity of a key enzyme in cholesterol biosynthesis and that a receptor deficiency is responsible for a major genetic cause of hypercholesterolemia and premature atherosclerosis.
authors: Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720.
authors: Randy
authors: R
authors: Schekman
mesh_terms: D002784:Cholesterol / Q000266:history* / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics / Q000266:history / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000266:history / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics / Q000266:history / Q000378:metabolism; D014481:United States
chemical_list: D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D002784:Cholesterol
keywords: HMG-CoA; endocytosis; lysosome; reductase
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