title: Enantioselective total synthesis of otteliones A and B, novel and powerful antitumor agents from the freshwater plant Ottelia alismoides.
abstract: Otteliones A and B, isolated from the freshwater plant Ottelia alismoides, have attracted significant attention because of their potential as novel anticancer agents. In this review, four independent enantioselective total syntheses and one formal synthesis of these natural products are presented with particular focus on their methodology and strategy.
authors: Laboratory of Synthetic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. katoh@tohoku-pharm.ac.jp
authors: Tadashi
authors: T
authors: Katoh
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D003512:Cyclohexanones / Q000138:chemical synthesis*; D005618:Fresh Water; D031321:Hydrocharitaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; C468748:ottelione A; C468747:ottelione B