title: Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.
abstract: A wide variety of acute and chronic neurodegenerative diseases, including ischemic/traumatic brain injury, Alzheimer's disease, and Parkinson's disease, share common characteristics such as oxidative stress, misfolded proteins, excitotoxicity, inflammation, and neuronal loss. As no drugs are available to prevent the progression of these neurological disorders, intervention strategies using phytochemicals have been proposed as an alternative form of treatment. Among phytochemicals, isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects in several in vitro and in vivo studies. In particular, evidence suggests that sulforaphane beneficial effects could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway. Therefore, sulforaphane appears to be a promising compound with neuroprotective properties that may play an important role in preventing neurodegeneration.
authors: Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Rimini, Italy.
authors: Andrea
authors: A
authors: Tarozzi
authors: Cristina
authors: C
authors: Angeloni
authors: Marco
authors: M
authors: Malaguti
authors: Fabiana
authors: F
authors: Morroni
authors: Silvana
authors: S
authors: Hrelia
authors: Patrizia
authors: P
authors: Hrelia
mesh_terms: D000818:Animals; D005961:Glucosinolates / Q000627:therapeutic use; D006801:Humans; D007096:Imidoesters / Q000627:therapeutic use; D017879:Isothiocyanates / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D010091:Oximes; D013454:Sulfoxides; D013861:Thiocyanates / Q000627:therapeutic use
chemical_list: D005961:Glucosinolates; D007096:Imidoesters; D017879:Isothiocyanates; D018696:Neuroprotective Agents; D010091:Oximes; D013454:Sulfoxides; D013861:Thiocyanates; C037152:isothiocyanic acid; C016766:sulforaphane; C119494:glucoraphanin
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