title: Association of a common variant at 10q26 and benign prostatic hyperplasia aggressiveness in han chinese descent.
abstract: Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). The current study included 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. All BPH patients were treated with α -adrenergic blockers and 5 α -reductase inhibitors for at least 9 months. Associations between rs2252004 and BPH risk/aggressiveness were tested using logistic regression. Associations between rs2252004 and clinical parameters including International Prostate Symptom Score (IPSS), total prostate volume (TPV), total PSA (tPSA), and free PSA (fPSA) were evaluated by linear regression. Allele "A" in rs2252004 was significantly associated with increased risk for aggressiveness of BPH in a Chinese population (OR = 1.42, 95% CI: 1.04-1.96, P = 0.03). Patients with the genotype "A/A" (homozygous minor allele) had an increase of IPSS and TPV after treatment (P = 0.045 and 0.024, resp.). No association was observed between rs2252004, BPH risk, and baseline clinicopathological traits (All P > 0.05). Our study is the first to show that rs2252004 at 10q26 was associated with BPH aggressiveness and efficacy of BPH treatment.
authors: Department of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, China.
authors: Xin
authors: X
authors: Gu
authors: Tao
authors: T
authors: Huang
authors: Ding
authors: D
authors: Xu
authors: Liujian
authors: L
authors: Duan
authors: Yang
authors: Y
authors: Jiao
authors: Jian
authors: J
authors: Kang
authors: S Lilly
authors: SL
authors: Zheng
authors: Jianfeng
authors: J
authors: Xu
authors: Jielin
authors: J
authors: Sun
authors: Jun
authors: J
authors: Qi
references: Prostate. 2013 Aug;73(11):1182-90
references: 23620269
references: Asian J Androl. 2013 May;15(3):314-22
references: 23564047
references: Mol Carcinog. 2013 Nov;52(11):916-21
references: 22711262
references: Nat Genet. 2012 Nov;44(11):1231-5
references: 23023329
references: Carcinogenesis. 2012 Feb;33(2):356-60
references: 22114074
references: N Engl J Med. 2003 Dec 18;349(25):2387-98
references: 14681504
references: Am J Hum Genet. 2010 Oct 8;87(4):465-79
references: 20887964
references: Nat Genet. 2012 Feb 26;44(4):426-9, S1
references: 22366784
references: Aust Fam Physician. 2007 Oct;36(10):820-4
references: 17925902
references: BJU Int. 2006 Apr;97(4):852-5
references: 16536786
references: J Urol. 2013 Aug;190(2):615-9
references: 23499746
references: Nat Genet. 2011 Jun;43(6):570-3
references: 21602798
references: Br J Pharmacol. 1996 Jul;118(6):1403-8
references: 8832064
references: Eur Urol. 2009 Apr;55(4):864-73
references: 19027219
references: Nat Genet. 2011 Jul 10;43(8):785-91
references: 21743467
references: Cancer Genet Cytogenet. 2005 Apr 15;158(2):142-7
references: 15796961
references: Cancer Res. 1996 May 1;56(9):2143-7
references: 8616863
references: Cancer. 1992 Jul 1;70(1 Suppl):291-301
references: 1376199
references: Int J Mol Sci. 2013 Apr 24;14(5):8832-40
references: 23615473
references: Urology. 1999 Mar;53(3 Suppl 3a):1-6
references: 10094094
references: Korean J Urol. 2012 Apr;53(4):248-52
references: 22536467
references: Am J Hum Genet. 2007 Sep;81(3):559-75
references: 17701901
references: Cancer Sci. 2011 Oct;102(10):1916-20
references: 21756274