title: Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration.
abstract: Injuries to central nervous system axons result not only in Wallerian degeneration of the axon distal to the injury, but also in death or atrophy of the axotomized neurons, depending on injury location and neuron type. No method of permanently avoiding these changes has been found, despite extensive knowledge concerning mechanisms of secondary neuronal injury. The autonomous endoplasmic reticulum (ER) stress pathway in neurons has recently been implicated in retrograde neuronal degeneration. In addition to the emerging role of ER morphology in axon maintenance, we propose that ER stress is a common neuronal response to disturbances in axon integrity and a general mechanism for neurodegeneration. Thus, manipulation of the ER stress pathway could have important therapeutic implications for neuroprotection.
authors: Shriners Hospitals Pediatric Research Center (Center for Neural Repair and Rehabilitation), Temple University School of Medicine, Philadelphia, PA; Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: Shaohua
authors: S
authors: Li
authors: Liu
authors: L
authors: Yang
authors: Michael E
authors: ME
authors: Selzer
authors: Yang
authors: Y
authors: Hu
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology
references: Genes Dev. 2009 Oct 1;23(19):2294-306
references: 19762508
references: Science. 2011 Sep 30;333(6051):1891-4
references: 21852455
references: Physiol Rev. 2011 Oct;91(4):1219-43
references: 22013210
references: Eur J Neurosci. 2007 Jun;25(11):3339-46
references: 17553002
references: Nat Rev Drug Discov. 2008 Dec;7(12):1013-30
references: 19043451
references: Nat Neurosci. 2009 May;12(5):627-36
references: 19330001
references: Brain. 2009 Jan;132(Pt 1):8-15
references: 18790819
references: Brain Res. 2010 Jan 13;1308:158-66
references: 19853589
references: Cell. 2007 Jun 29;129(7):1337-49
references: 17604722
references: Trends Neurosci. 2000 May;23(5):222-9
references: 10782128
references: J Cell Biol. 2009 Aug 10;186(3):323-31
references: 19651891
references: Neuroscience. 2011 Mar 31;178:33-44
references: 21241777
references: J Comp Neurol. 2011 Oct 1;519(14):2852-69
references: 21618218
references: Cell. 2009 Aug 7;138(3):562-75
references: 19665977
references: Cell Metab. 2009 Jul;10(1):13-26
references: 19583950
references: Exp Neurol. 2010 May;223(1):5-10
references: 19699198
references: Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1460-6
references: 22297499
references: J Comp Neurol. 1984 Dec 1;230(2):231-48
references: 6210310
references: Neurol Res. 2012 Jan;34(1):85-90
references: 22196867
references: Annu Rev Pathol. 2008;3:399-425
references: 18039139
references: Science. 2000 Jan 28;287(5453):664-6
references: 10650002
references: Hum Mol Genet. 2011 Jun 1;20(11):2144-60
references: 21389082
references: Biochim Biophys Acta. 2012 Feb;1823(2):327-34
references: 22182703
references: Nat Neurosci. 2010 Feb;13(2):190-6
references: 20037574
references: J Neurosci. 1994 Jul;14(7):4368-74
references: 8027784
references: Cell Death Differ. 2011 Feb;18(2):328-37
references: 20798690
references: Nat Rev Neurosci. 2009 Apr;10(4):251-61
references: 19259102
references: Oncogene. 2008 Oct 27;27(50):6407-18
references: 18955969
references: FASEB J. 2011 Sep;25(9):3115-29
references: 21680894
references: Science. 2007 Nov 9;318(5852):944-9
references: 17991856
references: Nat Cell Biol. 2013 May;15(5):481-90
references: 23624402
references: J Clin Invest. 2009 Oct;119(10):2925-41
references: 19741297
references: Curr Opin Neurobiol. 2008 Jun;18(3):276-83
references: 18655834
references: J Comp Neurol. 2008 Sep 20;510(3):269-82
references: 18634003
references: J Vasc Surg. 2010 Dec;52(6):1580-6
references: 20843623
references: Neurology. 2007 Oct 9;69(15):1480-90
references: 17881719
references: Mol Vis. 2007 Apr 05;13:578-87
references: 17438523
references: FASEB J. 2010 May;24(5):1419-30
references: 20008544
references: Dev Cell. 2007 Sep;13(3):351-64
references: 17765679
references: J Neurosci. 2008 Jan 2;28(1):264-78
references: 18171944
references: J Cell Biol. 2012 Jan 9;196(1):7-18
references: 22232700
references: EMBO J. 2009 Jun 17;28(12):1757-68
references: 19339988
references: Brain Res. 2011 Jan 7;1367:85-93
references: 20940001
references: J Electron Microsc (Tokyo). 1976;25(3):141-9
references: 1025229
references: Cell Death Dis. 2012 Feb 16;3:e272
references: 22337234
references: J Clin Invest. 2008 Oct;118(10):3378-89
references: 18776938
references: Glia. 2011 Oct;59(10):1489-502
references: 21638341
references: Antioxid Redox Signal. 2007 Dec;9(12):2277-93
references: 17979528
references: J Cell Biol. 2011 Sep 5;194(5):751-64
references: 21893599
references: Neurotox Res. 2010 Feb;17(2):189-202
references: 19763736
references: Brain. 2010 Sep;133(9):2612-25
references: 20495185
references: Brain Res. 2011 Jan 25;1370:227-37
references: 21075086
references: Prog Retin Eye Res. 2012 Mar;31(2):152-81
references: 22155051
references: Nat Neurosci. 2009 Apr;12(4):379-85
references: 19287390
references: Nat Neurosci. 2001 Dec;4(12):1199-206
references: 11770485
references: Trends Neurosci. 2002 Oct;25(10):532-7
references: 12220882
references: Neuron. 2012 Feb 9;73(3):445-52
references: 22325198
references: J Neurosci. 2010 Aug 25;30(34):11516-28
references: 20739574
references: Int Rev Neurobiol. 2012;105:1-17
references: 23206593
references: Genes Dev. 2004 Dec 15;18(24):3066-77
references: 15601821
references: J Neurobiol. 1993 Jan;24(1):23-36
references: 8419522
references: Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1632-6
references: 8127857
references: J Biol Chem. 2007 Nov 23;282(47):34525-34
references: 17890727
references: Mol Cell Neurosci. 2012 Jun;50(2):136-46
references: 22522146
references: Genes Dev. 2008 Jun 1;22(11):1451-64
references: 18519638
references: Science. 2002 May 3;296(5569):868-71
references: 11988563
references: J Biol Chem. 2005 Oct 28;280(43):36334-41
references: 16118205
references: Prog Retin Eye Res. 2005 Nov;24(6):639-62
references: 15953750
references: Mol Cell Biol. 2001 Feb;21(4):1249-59
references: 11158311
references: J Neurosci. 2011 Jan 19;31(3):966-78
references: 21248121
references: Trends Mol Med. 2010 Apr;16(4):160-70
references: 20207196
references: Nat Med. 2011 Mar;17(3):356-65
references: 21317886
references: PLoS Biol. 2010 Jan 26;8(1):e1000300
references: 20126265
references: Cell. 2006 Sep 8;126(5):981-93
references: 16959576
references: J Neurosci. 2010 Dec 15;30(50):16938-48
references: 21159964
references: J Cell Mol Med. 2011 Oct;15(10):2025-39
references: 21722302
references: Nature. 2012 Jul 26;487(7408):443-8
references: 22801498
references: J Cell Biol. 2009 Feb 23;184(4):491-500
references: 19237596
references: J Neurosci. 2008 Feb 27;28(9):2168-78
references: 18305250
references: Nat Neurosci. 2013 May;16(5):571-9
references: 23542689
references: Cell. 2012 Jun 8;149(6):1257-68
references: 22682248
references: Trends Cell Biol. 2011 Apr;21(4):219-27
references: 21215635
references: Cell Death Differ. 2006 Mar;13(3):385-92
references: 16397584
references: EMBO J. 2012 Mar 21;31(6):1350-63
references: 22246183
references: Oncogene. 2008 Oct 20;27(48):6245-51
references: 18931691
references: Brain Res. 2007 Sep 12;1169:24-33
references: 17707355
references: Nat Neurosci. 2009 Apr;12(4):387-9
references: 19287387
references: Neurobiol Dis. 2012 May;46(2):393-401
references: 22353563
references: Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
references: 17565364
references: Cell Death Differ. 2011 Oct;18(10):1617-27
references: 21436843
references: J Clin Invest. 2012 Feb;122(2):538-44
references: 22232211
references: J Neurochem. 2007 Aug;102(4):1242-55
references: 17578450
references: Trends Neurosci. 2012 Jun;35(6):364-72
references: 22578891
references: Annu Rev Neurosci. 2012;35:25-47
references: 22540978
references: J Cell Biol. 2009 Sep 21;186(6):783-92
references: 19752026
references: Exp Neurol. 2013 Aug;246:72-83
references: 22285449
references: Brain. 2009 Feb;132(Pt 2):402-16
references: 19059977