title: What causes internalising traits and autistic traits to co-occur in adolescence? A community-based twin study.
abstract: Autism shows a high degree of comorbidity with anxiety disorders. Adolescence is a time of increased stress and vulnerability to internalising problems. This study addresses for the first time the degree of genetic and environmental overlap between autistic traits (total measure and subscales) and internalising traits in a community-based adolescent twin sample. Parents of 12-14-year-old twins (N = 3,232 pairs; 3,460 males, 3,004 females) reported on the twins' internalising and autistic traits. Autistic trait subscales were created using principal component analysis. Bivariate twin model-fitting was conducted. Autistic and internalising traits correlated moderately (r = 0.30). Genetic influences on individual traits were substantial but genetic overlap between traits was moderate (genetic correlation: males = 0.30, females = 0.12). Shared environmental influences were low for internalising traits and moderate for autistic traits, and showed considerable overlap (shared environmental correlation: males = 0.53, females = 1). Nonshared environmental influences were moderate for internalising traits and low for autistic traits and showed low overlap. A multiple component solution was found for autistic traits and of the derived subscales, autistic-like 'Social Unease' showed the most phenotypic and genetic overlap with internalising traits.
authors: Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck, University of London, 32 Torrington Square, London, WC1E 7JL, UK, a.scherff@psychology.bbk.ac.uk.
authors: Aline
authors: A
authors: Scherff
authors: Mark
authors: M
authors: Taylor
authors: Thalia C
authors: TC
authors: Eley
authors: Francesca
authors: F
authors: Happé
authors: Tony
authors: T
authors: Charman
authors: Angelica
authors: A
authors: Ronald
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000235:genetics / Q000523:psychology; D001321:Autistic Disorder / Q000235:genetics / Q000523:psychology; D002648:Child; D015897:Comorbidity; D003863:Depression / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics / Q000523:psychology; D005163:Factor Analysis, Statistical; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D007389:Internal-External Control; D008297:Male; D012931:Social Environment
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