title: Early and late outcomes of total repair of tetralogy of Fallot: risk factors for late right ventricular dilatation.
abstract: OBJECTIVE
  This study was undertaken to assess the early and long-term results of total repair of tetralogy of Fallot (TOF) and to identify the risk factors associated with late right ventricular (RV) dilatation.
  
  
  METHODS
  The medical records of 326 patients (male:female = 192:134) who underwent total repair of TOF at Pusan National and Dong-A University Hospitals between July 1991 and May 2011 were retrospectively reviewed. Median age and weight at the time of operation were 13.0 months and 8.7 kg, respectively. Right ventricular end-diastolic dimensions and left ventricular end-diastolic dimensions were obtained during follow-up echocardiography to identify the risk factors associated with late RV dilatation.
  
  
  RESULTS
  There were one operative death (0.3%) and 8 late deaths (2.5%). Of late deaths, two were related to operation-related cardiac problems. Overall survival rates at 5, 10, and 15 years were 97.0%, 95.4%, and 95.4%, and the corresponding freedom from cardiac death were 98.8%, 98.8%, and 98.8%, respectively. Freedom from re-operation and re-intervention were 84.4%, 74.2% and 74.2%. Six patients underwent pulmonary valve replacement during the follow-up period. Transannular patch (P = 0.036) and postoperative ventilator support period (P < 0.001) were found to be significant risk factors of late RV dilatation in multivariate analysis.
  
  
  CONCLUSIONS
  Total correction of TOF can be performed with a very low mortality rate. However, the postoperative re-operation or re-intervention rates remain relatively high. Late RV dilatation after total repair of TOF was found to be associated with transannular patch enlargement and a longer postoperative ventilator support period.
authors: Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Medical Research Institute of Pusan National University, Busan, Republic of Korea.
authors: Hyungtae
authors: H
authors: Kim
authors: Si Chan
authors: SC
authors: Sung
authors: Si-Ho
authors: SH
authors: Kim
authors: Yun Hee
authors: YH
authors: Chang
authors: Hyoung Doo
authors: HD
authors: Lee
authors: Ji Ae
authors: JA
authors: Park
authors: Young Seok
authors: YS
authors: Lee
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000401:mortality; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004108:Dilatation, Pathologic; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006785:Hospitals, University; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011664:Pulmonary Valve / Q000503:physiopathology / Q000601:surgery; D012086:Reoperation; D056910:Republic of Korea; D012121:Respiration, Artificial / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013771:Tetralogy of Fallot / Q000401:mortality / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D016278:Ventricular Function, Right
keywords: Congenital heart disease; Pulmonary regurgitation; Pulmonary valve replacement; Right ventricular dysfunction; Tetralogy of Fallot
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