title: Metabolic regulation by p53 family members.
abstract: The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs.
authors: The CR-UK Beatson Institute, Glasgow G61 1BD, Scotland, UK.
authors: Celia R
authors: CR
authors: Berkers
authors: Oliver D K
authors: OD
authors: Maddocks
authors: Eric C
authors: EC
authors: Cheung
authors: Inbal
authors: I
authors: Mor
authors: Karen H
authors: KH
authors: Vousden
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D004194:Disease; D006801:Humans; D053858:Metabolic Networks and Pathways; D017382:Reactive Oxygen Species / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53
references: Nature. 2007 Jul 19;448(7151):375-9
references: 17637672
references: J Mol Med (Berl). 2011 Mar;89(3):237-45
references: 21340684
references: Genes Dev. 2011 May 15;25(10):1041-51
references: 21576264
references: Nature. 1992 Mar 19;356(6366):215-21
references: 1552940
references: Nature. 2013 Jan 24;493(7433):542-6
references: 23242140
references: Mol Cell Biol. 2001 Mar;21(5):1874-87
references: 11238924
references: Biochem Biophys Res Commun. 2001 Sep 21;287(2):562-7
references: 11554766
references: Science. 2006 Jun 16;312(5780):1650-3
references: 16728594
references: Free Radic Biol Med. 2012 Sep 15;53(6):1279-85
references: 22841759
references: Leukemia. 2009 Apr;23(4):784-90
references: 19225536
references: Cancer Res. 2012 Jan 15;72(2):560-7
references: 22123926
references: Cancer Discov. 2012 Apr;2(4):328-43
references: 22576210
references: Nature. 2013 Jan 31;493(7434):689-93
references: 23334421
references: Cell Stem Cell. 2009 Jul 2;5(1):64-75
references: 19570515
references: Trends Endocrinol Metab. 2011 Mar;22(3):94-102
references: 21269838
references: Cell Cycle. 2012 Oct 15;11(20):3810-27
references: 22951905
references: J Carcinog. 2009;8:8
references: 19439913
references: Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18511-6
references: 20937856
references: Science. 2012 Apr 13;336(6078):225-8
references: 22499945
references: EMBO J. 2002 Nov 15;21(22):6225-35
references: 12426394
references: Cell Death Differ. 2009 Aug;16(8):1135-45
references: 19300452
references: J Hepatol. 2011 Jan;54(1):164-72
references: 20961644
references: Cancer Res. 2005 May 1;65(9):3745-50
references: 15867370
references: Cancer Res. 2005 Jan 1;65(1):177-85
references: 15665293
references: J Biol Chem. 2003 Jul 11;278(28):25395-400
references: 12734185
references: Cell Cycle. 2009 Dec 15;8(24):4168-75
references: 20054236
references: Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8823-8
references: 9671763
references: Exp Cell Res. 2012 Jul 1;318(11):1285-90
references: 22326462
references: Oncogene. 2009 Feb 19;28(7):1040-52
references: 19079340
references: EMBO J. 2004 Nov 24;23(23):4679-89
references: 15526035
references: Mol Biol Cell. 2004 Nov;15(11):4829-40
references: 15331765
references: Cancer Res. 2012 Feb 15;72(4):939-48
references: 22184616
references: Mol Cell. 2010 Oct 22;40(2):310-22
references: 20965424
references: Autophagy. 2012 Jan;8(1):88-97
references: 22170151
references: J Biol Chem. 2012 Dec 7;287(50):42053-63
references: 23074225
references: Aging (Albany NY). 2012 Jul;4(7):450-5
references: 22869016
references: Cell Death Differ. 2009 Jan;16(1):1-2
references: 19079285
references: Biochim Biophys Acta. 2009 May;1787(5):328-34
references: 19413947
references: Cell. 2012 Jan 20;148(1-2):244-58
references: 22265415
references: Cancer Res. 2012 Sep 1;72(17):4394-404
references: 22728651
references: Nature. 2011 Feb 17;470(7334):359-65
references: 21307849
references: Oncotarget. 2012 Nov;3(11):1272-83
references: 23174755
references: Cancer Cell. 2013 Feb 11;23(2):143-58
references: 23352126
references: Mol Cell Biol. 2012 Jan;32(2):348-64
references: 22064482
references: Oncol Res. 1999;11(6):281-5
references: 10691030
references: Cancer Cell. 2012 Mar 20;21(3):297-308
references: 22439925
references: Cell. 2012 Jun 22;149(7):1536-48
references: 22726440
references: J Biol Chem. 2004 May 14;279(20):20571-5
references: 14985341
references: Nat Cell Biol. 2004 Nov;6(11):1122-8
references: 15467718
references: Cancer Res. 2006 May 1;66(9):4715-24
references: 16651424
references: PLoS One. 2008;3(11):e3707
references: 19002260
references: Mol Cell Biol. 2010 Dec;30(24):5787-94
references: 20956556
references: Autophagy. 2012 Jan;8(1):18-28
references: 22082963
references: Nat Genet. 2007 Jan;39(1):99-105
references: 17143283
references: Cell Metab. 2012 Oct 3;16(4):511-25
references: 23040072
references: Nature. 2002 Sep 26;419(6905):367-74
references: 12353028
references: J Mol Cell Biol. 2013 Apr;5(2):147-50
references: 23258697
references: Nature. 2009 Apr 23;458(7241):1056-60
references: 19262508
references: Antioxid Redox Signal. 2012 Dec 15;17(12):1670-5
references: 22559194
references: Cancer Res. 2007 Apr 1;67(7):3043-53
references: 17409411
references: Antioxid Redox Signal. 2013 Feb 1;18(4):386-99
references: 22861165
references: Cell Cycle. 2012 Dec 15;11(24):4589-96
references: 23187810
references: Autophagy. 2008 Oct;4(7):866-9
references: 18719357
references: PLoS One. 2009 Jun 11;4(6):e5877
references: 19517019
references: Mol Cell. 2009 Jun 26;34(6):663-73
references: 19560419
references: Nat Genet. 2007 Jun;39(6):776-80
references: 17486094
references: Cancer Res. 1997 Oct 1;57(19):4242-8
references: 9331084
references: J Biol Chem. 2000 Sep 22;275(38):29900-6
references: 10893413
references: Genes Dev. 2004 Feb 1;18(3):306-19
references: 14871929
references: Cell. 2009 May 1;137(3):413-31
references: 19410540
references: Diabetes. 2011 Apr;60(4):1210-22
references: 21357466
references: Science. 2009 May 22;324(5930):1029-33
references: 19460998
references: Pathobiology. 2008;75(2):132-9
references: 18544968
references: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13314-8
references: 22847439
references: Nat Cell Biol. 2008 May;10(5):611-8
references: 18391940
references: Cell Cycle. 2012 Mar 15;11(6):1247-59
references: 22356768
references: Cancer Res. 2008 Jan 15;68(2):352-7
references: 18199527
references: Eur J Cancer. 2010 Sep;46(13):2369-80
references: 20656475
references: J Biol Chem. 2009 Jan 16;284(3):1748-54
references: 19015259
references: Oncogene. 2011 Mar 3;30(9):1127-34
references: 21057531
references: EMBO J. 2007 Nov 28;26(23):4812-23
references: 17962806
references: Oncogene. 2007 Feb 26;26(9):1306-16
references: 17322916
references: PLoS One. 2011 Jan 17;6(1):e16060
references: 21264228
references: Br J Cancer. 2006 Feb 27;94(4):578-85
references: 16465194
references: Hum Pathol. 2012 Feb;43(2):221-8
references: 21820150
references: Cancer Res. 2012 Apr 15;72(8):1996-2005
references: 22345153
references: Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
references: 22436748
references: Cell. 2008 Aug 8;134(3):451-60
references: 18692468
references: Int J Oncol. 2010 Nov;37(5):1061-70
references: 20878053
references: Cancer Res. 2009 Jan 1;69(1):219-26
references: 19118006
references: Nat Cell Biol. 2011 Mar;13(3):310-6
references: 21336310
references: Nature. 2009 Apr 30;458(7242):1127-30
references: 19407794
references: J Biol Chem. 2006 Dec 29;281(52):39776-84
references: 17077087
references: Biochem Biophys Res Commun. 2008 Jul 18;372(1):137-41
references: 18477470
references: Oncogene. 2008 Dec;27 Suppl 1:S71-83
references: 19641508
references: Cancer Res. 2004 Apr 1;64(7):2627-33
references: 15059920
references: J Biol Chem. 2005 Aug 12;280(32):29346-54
references: 15914462
references: Cell Cycle. 2010 Feb 15;9(4):720-8
references: 20160513
references: Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C4-C13
references: 22378745
references: Genes Dev. 2006 Jan 1;20(1):16-21
references: 16391230
references: Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):358-65
references: 16778563
references: Dev Cell. 2013 Jun 10;25(5):463-77
references: 23726973
references: J Biol Chem. 2012 Sep 28;287(40):33436-46
references: 22887998
references: Cell. 2009 Dec 24;139(7):1327-41
references: 20064378
references: Cancer Res. 1990 Jul 1;50(13):3921-7
references: 2112982
references: Nat Rev Mol Cell Biol. 2012 May 16;13(6):397-404
references: 22588366
references: Aging (Albany NY). 2010 Jun;2(6):344-52
references: 20606252
references: J Hepatol. 2013 Apr;58(4):785-91
references: 23211317
references: Nat Cell Biol. 2008 Jun;10(6):676-87
references: 18454141
references: J Biol Chem. 2010 Nov 26;285(48):37503-12
references: 20861022
references: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3431-6
references: 19202066
references: Nature. 1964 May 2;202:464-6
references: 14167826
references: Oncol Res. 1993;5(9):357-62
references: 8038456
references: Genes Dev. 2012 Sep 15;26(18):2009-14
references: 22987635
references: Mol Cell. 2009 Nov 13;36(3):379-92
references: 19917247
references: Cell Death Differ. 2007 Jun;14(6):1071-9
references: 17304243
references: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7461-6
references: 20351271
references: Genes Cancer. 2011 Apr;2(4):503-16
references: 21779518
references: Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8204-9
references: 15928081
references: Endocr Res. 2013 Aug;38(3):139-150
references: 23102272
references: Oncogene. 2002 Oct 17;21(47):7195-204
references: 12370809
references: Nat Med. 2009 Sep;15(9):1082-7
references: 19718037
references: Cell Cycle. 2008 Oct;7(19):3056-61
references: 18818522
references: J Clin Invest. 2010 Jan;120(1):103-14
references: 20038814
references: Expert Opin Ther Targets. 2009 Feb;13(2):235-46
references: 19236241
references: J Biol Chem. 1997 Sep 5;272(36):22776-80
references: 9278438
references: Cell. 2012 Jun 8;149(6):1269-83
references: 22682249
references: Cancer Res. 2007 Jul 15;67(14):6745-52
references: 17638885
references: Cell Death Differ. 2006 Dec;13(12):2140-9
references: 16729031
references: FEBS J. 2012 Aug;279(15):2610-23
references: 22621751
references: Clin Lipidol. 2009 Apr 1;4(2):231-243
references: 20126301
references: Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35
references: 21157483
references: Sci Rep. 2012;2:785
references: 23139858
references: Nat Rev Drug Discov. 2012 Sep;11(9):709-30
references: 22935804
references: Nature. 2002 Jan 3;415(6867):45-53
references: 11780111
references: J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94
references: 19812304
references: Cell. 2011 Aug 5;146(3):408-20
references: 21816276
references: Cell Growth Differ. 1999 May;10(5):295-306
references: 10359011
references: Exp Cell Res. 2002 Sep 10;279(1):80-90
references: 12213216
references: Mol Cell. 2011 Nov 4;44(3):491-501
references: 22055193
references: Cell Death Differ. 2013 Jan;20(1):117-29
references: 22918438
references: Cancer Cell. 2012 Jul 10;22(1):66-79
references: 22789539
references: J Hum Genet. 2004;49(3):134-140
references: 14986171
references: Genes Dev. 2012 Sep 15;26(18):1997-2000
references: 22987633
references: Autophagy. 2009 Jan;5(1):114-6
references: 19001857
references: Cell Death Differ. 2008 Jun;15(6):1019-29
references: 18259198
references: Science. 1991 Jul 5;253(5015):49-53
references: 1905840
references: Trends Cell Biol. 2010 Jul;20(7):427-34
references: 20399660
references: Mol Cell Biol. 2008 Oct;28(19):5951-64
references: 18678646
references: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60
references: 20378837
references: Biochim Biophys Acta. 2009 Sep;1793(9):1524-32
references: 19371598
references: Med Hypotheses. 1998 Jan;50(1):55-9
references: 9488183
references: Hum Mutat. 2003 Mar;21(3):313-20
references: 12619118
references: Mol Biol Cell. 2009 Mar;20(5):1565-75
references: 19144819
references: Curr Opin Cell Biol. 2010 Apr;22(2):181-5
references: 20044243
references: Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2076-81
references: 21245298
references: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20491-6
references: 23185017
references: Genes Dev. 1996 Apr 15;10(8):934-47
references: 8608941
references: Cell. 2006 Jul 14;126(1):121-34
references: 16839881
references: Radiother Oncol. 2011 Oct;101(1):132-9
references: 21864926
references: Oncogene. 2012 Apr 12;31(15):1949-62
references: 21909130
references: Cell. 2011 May 13;145(4):571-83
references: 21565614
references: Trends Endocrinol Metab. 2012 Nov;23(11):567-75
references: 22819212
references: Carcinogenesis. 1985 Sep;6(9):1371-3
references: 4028334
references: Mech Ageing Dev. 2009 Apr;130(4):262-71
references: 19396980
references: PLoS One. 2012;7(7):e41455
references: 22848499
references: Int J Cancer. 2006 Dec 15;119(12):2733-41
references: 17019714
references: EMBO J. 2009 Oct 7;28(19):3015-26
references: 19713938
references: Cell. 2006 Jul 14;126(1):107-20
references: 16839880
references: Curr Opin Genet Dev. 2009 Feb;19(1):32-7
references: 19201187
references: Cell. 2009 May 15;137(4):609-22
references: 19450511
references: Cell Death Differ. 2013 Apr;20(4):659-68
references: 23412344
references: Ann N Y Acad Sci. 1999;889:214-23
references: 10668496
references: J Inherit Metab Dis. 2008 Dec;31(6):703-17
references: 18987987
references: Mol Cell. 2005 Apr 29;18(3):283-93
references: 15866171
references: Genes Dev. 2005 Sep 1;19(17):1986-99
references: 16107615
references: Mol Cancer. 2010 Apr 29;9:95
references: 20429933
references: Mol Cell. 2011 Nov 18;44(4):621-34
references: 22099309
references: Anticancer Res. 1993 Jul-Aug;13(4):867-72
references: 8102518
references: Nat Rev Cancer. 2012 Jul 19;12(8):564-71
references: 22810811
references: Nature. 1965 Jan 2;205:50-1
references: 14283133