title: Successful treatment of granulomatous amoebic encephalitis with combination antimicrobial therapy.
abstract: Granulomatous amoebic encephalitis (GAE) is a rare but fatal infection. Due to its nonspecific symptoms and laboratory and neuroradiological findings, it is rarely diagnosed antemortem. We herein present the case of a 72-year-old Japanese woman who was diagnosed with GAE following the detection of a pathogen similar to Balamuthia mandrillaris under a microscopic examination of cerebrospinal fluid sediment and who achieved remission with combination antimicrobial therapy. There are no previous reports of pathogens similar to B. mandrillaris being detected in cerebrospinal fluid antemortem; therefore, this case may be used as a benchmark for further studies.
authors.affiliation: Department of Neurology, Tosei General Hospital, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kato
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Mitake
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yuasa
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Hayashi
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Hara
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Matsukawa
mesh_terms: D000368:Aged; D000562:Amebiasis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D059611:Balamuthia mandrillaris / Q000302:isolation & purification*; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents