title: [Secondary osteoporosis or secondary contributors to bone loss in fracture. Bone metabolism in hematological disorders].
abstract: Bone marrow provides a microenvironment responsible for hematopoiesis, in which osteoclasts and osteoblasts interact with each other to maintain bone remodeling. Multiple myeloma and a portion of lymphoid tumors have a unique propensity to expand in bone. Such tumors have been demonstrated to perturb bone metabolism and skew a microenvironment in bone suited for their growth and survival. However, a bone metabolic state remains largely unknown in most of hematological disorders without apparent bone disease, although hematopoiesis and bone metabolism appear to have a link. Also, the skeletal effects of treatment for hematological disorders should be clarified further.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D050723:Fractures, Bone / Q000209:etiology / Q000378:metabolism*; D006402:Hematologic Diseases / Q000150:complications / Q000276:immunology / Q000378:metabolism; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010024:Osteoporosis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*