title: Translational research in melanoma.
abstract: Recent breakthroughs in the fundamental understanding of the cellular and molecular basis of melanoma have culminated in new therapies with unquestionable efficacy. Immunotherapy and targeted therapy strategies have completely transformed the contemporary management of advanced melanoma. The translational research behind these developments is discussed, with an emphasis on immune checkpoint blockade and inhibition of the mitogen-activated protein kinase signaling pathway.
authors.affiliation: Division of General Surgery, Department of Surgery, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Madhury
authors.initials: M
authors.lastname: Ray
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Farma
authors.forename: Cary
authors.initials: C
authors.lastname: Hsu
mesh_terms: D000818:Animals; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D058990:Molecular Targeted Therapy; D057170:Translational Research, Biomedical
keywords: Immunotherapy; Melanoma; Targeted therapy; Translational research