title: Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction.
abstract: A novel Pd-catalysed C-H activation reaction for the synthesis of biaryl imino/keto carboxylic acids is developed. This reaction underwent aryl amide directed C-H activation ortho-acylation followed by ring closing and ring opening processes to give a range of biaryl imino/keto carboxylic acids. Our methodology features the utilization of a cheap and green oxidant (TBHP) as well as readily available aldehydes.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. jhuang@tju.edu.cn kangzhao@tju.edu.cn.
authors.forename: Nana
authors.initials: N
authors.lastname: Zhang
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Yu
authors.forename: Ruixue
authors.initials: R
authors.lastname: Chen
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Xia
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000577:Amides; D002384:Catalysis; D055772:Green Chemistry Technology; D007097:Imines / Q000737:chemistry*; D007651:Keto Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000577:Amides; D007097:Imines; D007651:Keto Acids; D010165:Palladium