title: Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch.
abstract: Rigenolide A (1), a new secoiridoid glucoside with a cyclobutane skeleton and three new acylated secoiridoid glucosides, 2'-(2,3-dihydroxybenzoyl)-gentiopicroside (2), 2'-(2,3-dihydroxybenzoyl)-swertiamarin (3), 3'-(2,3-dihydroxybenzoyl)-sweroside (4), along with two noriridoids (7 and 8) and two known secoiridoid glucosides (5 and 6), were isolated from Gentiana rigescens Franch. The structures of new compounds were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for DPPH free-radical scavenging activity.
authors.affiliation: Graduate school of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi,Uncorrected proof. Tokushima 770-8505, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Suyama
authors.affiliation: Graduate school of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi,Uncorrected proof. Tokushima 770-8505, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Kurimoto
authors.affiliation: Department of Clinical Pharmacy, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima 770-8503, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawazoe
authors.affiliation: Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 862-0082, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Murakami
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.affiliation: Graduate school of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi,Uncorrected proof. Tokushima 770-8505, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.affiliation: Graduate school of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi,Uncorrected proof. Tokushima 770-8505, Japan. Electronic address: kasiwada@tokushima-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
mesh_terms: D000215:Acylation; D001713:Biphenyl Compounds / Q000378:metabolism; D030012:Gentiana / Q000737:chemistry*; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D057888:Iridoid Glucosides; D010851:Picrates; D010936:Plant Extracts; D011753:Pyrones; C012997:gentiopicroside; C013270:swertiamarin; C004931:1,1-diphenyl-2-picrylhydrazyl; C049412:sweroside
keywords: DPPH radical; Gentiana rigescens; Gentianaceae; Noriridoid; Secoiridoid