title: A novel subtype of myeloproliferative disorder? JAK2V617F-associated hypereosinophilia with hepatic venous thrombosis.
abstract: We report the case of a 27-year-old man, presenting with one episode of massive haematemesis and a history of persistent eosinophilia for the past 8 months. An evaluation revealed hepatic cirrhosis with portal hypertension, secondary to chronic Budd-Chiari syndrome. Further investigations confirmed a diagnosis of hypereosinophilic syndrome. Molecular genetic analysis was negative for FIP1L1-PDGFRA gene rearrangement, but positive for JAK2V617F mutation.
authors.affiliation: Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Sowjanya
authors.initials: S
authors.lastname: Dasari
authors.forename: Kushal
authors.initials: K
authors.lastname: Naha
authors.forename: Manjunath
authors.initials: M
authors.lastname: Hande
authors.forename: G
authors.initials: G
authors.lastname: Vivek
mesh_terms: D000328:Adult; D006502:Budd-Chiari Syndrome / Q000150:complications* / Q000235:genetics; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000235:genetics; D053614:Janus Kinase 2 / Q000235:genetics; D008103:Liver Cirrhosis / Q000150:complications* / Q000235:genetics; D008297:Male; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2