title: Novelties in pharmacological management of cardiopulmonary resuscitation.
abstract: OBJECTIVE
  The ultimate goal of cardiopulmonary resuscitation is long-term neurologically intact survival. Despite numerous well-designed studies, the medications currently used in advanced cardiac life support have not demonstrated success in this regard. This review describes the novel therapeutics under investigation to improve functional recovery and survival.
  
  
  RESULTS
  Whereas current medications focus on achieving return of spontaneous circulation and improved hemodynamics, novel therapies currently in development are focused on improving cellular survival and function by preventing metabolic derangement, protecting mitochondria, and preventing cell death caused by cardiac arrest. Improved cardiac and neurologic function and survival benefits have been observed using animal models of cardiopulmonary arrest.
  
  
  CONCLUSIONS
  Although substantial data have shown benefits using robust animal models, further human studies are necessary to investigate the potential long-term benefits of these therapies.
authors.affiliation: Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Bartos
authors.forename: Demetris
authors.initials: D
authors.lastname: Yannopoulos
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use; D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D002470:Cell Survival / Q000187:drug effects; D006323:Heart Arrest / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D020127:Recovery of Function / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D000889:Anti-Arrhythmia Agents; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents