title: Synthesis and anti-inflammatory activity of three nitro chalcones.
abstract: The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.
authors.affiliation: División Académica de Ciencias Básicas, Km 1 Carretera Cunduacán-Jalpa de M. Cunduacán, Tabasco 86690, Mexico.
authors.forename: Abraham
authors.initials: A
authors.lastname: Gómez-Rivera
authors.forename: Hidemí
authors.initials: H
authors.lastname: Aguilar-Mariscal
authors.forename: Nancy
authors.initials: N
authors.lastname: Romero-Ceronio
authors.forename: Luis F
authors.initials: LF
authors.lastname: Roa-de la Fuente
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Lobato-García
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D019540:Area Under Curve; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D012372:ROC Curve; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D002599:Chalcone
keywords: Anti-inflammatory; Carrageenan induced edema; Nitro chalcone; Synthesis