title: Coherent anti-Stokes Raman scattering microspectroscopic kinetic study of fast hydrogen bond formation in microfluidic devices.
abstract: The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 10(5) M(-1)s(-1) and k-1 > 333.3 s(-1), respectively.
authors.affiliation: Supramolecular and Homogeneous Catalysis, van't Hoff Institute for Molecular Sciences, University of Amsterdam , Science Park 904, 1098 XH Amsterdam, The Netherlands.
authors.forename: Gennady V
authors.initials: GV
authors.lastname: Oshovsky
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rago
authors.forename: James P R
authors.initials: JP
authors.lastname: Day
authors.forename: Maarten L
authors.initials: ML
authors.lastname: Soudijn
authors.forename: William
authors.initials: W
authors.lastname: Rock
authors.forename: Sapun H
authors.initials: SH
authors.lastname: Parekh
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ciancaleoni
authors.forename: Joost N H
authors.initials: JN
authors.lastname: Reek
authors.forename: Mischa
authors.initials: M
authors.lastname: Bonn
mesh_terms: D006860:Hydrogen Bonding; D007700:Kinetics; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D006845:Hydrocarbons, Fluorinated
chemical_list: D020005:Propanols; D011725:Pyridines; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated; C023666:pyridine