title: Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population.
abstract: BACKGROUND
  Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity.
  
  
  METHODS
  In this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects. Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity.
  
  
  RESULTS
  Genotype frequencies of VDR were significantly different between control and migraine patients. Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene (P = 0.018; OR = 1.81, 95% CI = 1.03-3.18) and FokI gene polymorphisms (P = 0.001; OR = 2.91, 95% CI = 1.47-5.77). Also f and t alleles were more frequent in the migraine patients. Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients (60.32 ± 1.87 versus 49.87 ± 2.69, resp., P = 0.004).
  
  
  CONCLUSIONS
  In conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients. Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.
authors.affiliation: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Motaghi
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Haghjooy Javanmard
authors.forename: Faraidoon
authors.initials: F
authors.lastname: Haghdoost
authors.forename: Mohamadhasan
authors.initials: M
authors.lastname: Tajadini
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saadatnia
authors.forename: Laleh
authors.initials: L
authors.lastname: Rafiee
authors.forename: Alireza
authors.initials: A
authors.lastname: Zandifar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007492:Iran; D008297:Male; D020326:Migraine without Aura / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human