title: RETRACTED: Evaluation of amorphous debranched starch as extended-release matrices in tablets.
abstract: This study aims to investigate the physicochemical and extended-release properties of amorphous debranched starch (ADBS) that is a linear short chain amylose derived from pullulanase enzymatic modification. The results show the completely amorphous ADBS was soluble in cold water, which developed into a disordered gel network at 25 °C. ADBS based tablets were able to extend drug release in different media. Drug release, which was accelerated by decreased pH and pancreatin, was barely affected by ionic strength. The kinetics of the drug release process that was dominated by Fickian diffusion was best fitted and interpreted by the Higuchi equation. The results indicate ADBS is an ideal hydrophilic excipient which extends the in vitro release of water-soluble drugs for 24 h.
authors.affiliation: The State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 LiHu Avenue, Wuxi 214122, Jiangsu Province, PR China. liuguodongwx@hotmail.com
authors.forename: Guodong
authors.initials: G
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Hong
authors.forename: Zhengbiao
authors.initials: Z
authors.lastname: Gu
mesh_terms: D018360:Crystallography, X-Ray; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009994:Osmolar Concentration; D010194:Pancreatin / Q000378:metabolism; D012212:Rheology; D012995:Solubility; D013213:Starch / Q000737:chemistry* / Q000378:metabolism; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D010194:Pancreatin; D013213:Starch; D006026:Glycoside Hydrolases; C100181:pullulanase
keywords: Amorphous debranched starch; Excipient; Extended release; Pullulanase; Tablet