title: In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model.
abstract: Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue. Hence, we epicardially implanted scaffolds of the magnesium fluoride-coated magnesium alloy LA63 in a swine model to assess biocompatibility and degradation kinetics. Chemical analysis of the pigs' organs revealed no toxic accumulation of magnesium ions in the skeletal muscle, myocardium, liver, kidney, and bone of the pigs 1, 3, and 6 months postimplantation. The implants were surrounded by a fibrous granulation tissue, but no signs of necrosis were histologically evaluable. A sufficiently slow degradation rate of the magnesium alloy scaffold can be demonstrated via micro-computed tomography investigation. We conclude that stabilizing scaffolds of the magnesium fluoride-coated magnesium alloy LA63 can be used for epicardial application because no significant adverse effects to myocardial tissue were noted. Thus, degradable stabilizing scaffolds of this magnesium alloy with a slow degradation rate can extend the indication of innovative biological and synthetic patch materials.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schilling
authors.forename: Gudrun
authors.initials: G
authors.lastname: Brandes
authors.forename: Igor
authors.initials: I
authors.lastname: Tudorache
authors.forename: Serghei
authors.initials: S
authors.lastname: Cebotari
authors.forename: Andres
authors.initials: A
authors.lastname: Hilfiker
authors.forename: Tanja
authors.initials: T
authors.lastname: Meyer
authors.forename: Christian
authors.initials: C
authors.lastname: Biskup
authors.forename: Michael
authors.initials: M
authors.lastname: Bauer
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Waldmann
authors.forename: Friedrich-Wilhelm
authors.initials: FW
authors.lastname: Bach
authors.forename: Axel
authors.initials: A
authors.lastname: Haverich
authors.forename: Thomas
authors.initials: T
authors.lastname: Hassel
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D006348:Cardiac Surgical Procedures / Q000295:instrumentation*; D019544:Equipment Failure Analysis; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D008274:Magnesium / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D011474:Prosthesis Design; D013552:Swine; D013556:Swine, Miniature; D054457:Tissue Scaffolds
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008274:Magnesium