title: Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis.
abstract: BACKGROUND
  Childhood asthma has become a critical public health problem because of its high morbidity and increasing prevalence. The impact of nutrition and other exposures during pregnancy on long-term health and development of children has been of increasing interest.
  
  
  OBJECTIVE
  We performed a systematic review and meta-analysis of the association of folate and folic acid intake during pregnancy and risk of asthma and other allergic outcomes in children.
  
  
  METHODS
  We performed a systematic search of 8 electronic databases for articles that examined the association between prenatal folate or folic acid exposure and risk of asthma and other allergic outcomes (eg, allergy, eczema, and atopic dermatitis) in childhood. We performed a meta-analysis by using a random-effects model to derive a summary risk estimate of studies with similar exposure timing, exposure assessment, and outcomes.
  
  
  RESULTS
  Our meta-analysis provided no evidence of an association between maternal folic acid supplement use (compared with no use) in the prepregnancy period through the first trimester and asthma in childhood (summary risk estimate: 1.01; 95% CI: 0.78, 1.30). Because of substantial heterogeneity in exposures and outcomes, it was not possible to generate summary measures for other folate indicators (eg, blood folate concentrations) and asthma or allergy-related outcomes; however, the preponderance of primary risk estimates was not elevated.
  
  
  CONCLUSIONS
  Our findings do not support an association between periconceptional folic acid supplementation and increased risk of asthma in children. However, because of the limited number and types of studies in the literature, additional research is needed.
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA (KSC, AMC, YPQ, NFD, and RJB), and Carter Consulting Inc, Atlanta, GA (JM).
authors.forename: Krista S
authors.initials: KS
authors.lastname: Crider
authors.forename: Amy M
authors.initials: AM
authors.lastname: Cordero
authors.forename: Yan Ping
authors.initials: YP
authors.lastname: Qi
authors.forename: Joseph
authors.initials: J
authors.lastname: Mulinare
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Dowling
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Berry
mesh_terms: D001249:Asthma / Q000453:epidemiology*; D002648:Child; D016208:Databases, Factual; D003876:Dermatitis, Atopic / Q000453:epidemiology; D019587:Dietary Supplements / Q000009:adverse effects*; D004485:Eczema / Q000453:epidemiology; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011297:Prenatal Exposure Delayed Effects; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D005492:Folic Acid