title: Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system.
abstract: Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory properties and their capacity to secrete various growth factors. Nevertheless, most of the transplanted cells die within the first hours after transplantation and induce a neuroinflammatory response. In order to increase the efficacy of MSC transplantation, it is thus imperative to completely characterise the mechanisms mediating neuroinflammation and cell death following MSC transplantation into the CNS. Consequently, different components of these cell death- and neuroinflammation-inducing pathways can be targeted in an attempt to improve the therapeutic potential of MSCs for CNS disorders.
authors.forename: Nathalie
authors.initials: N
authors.lastname: De Vocht
authors.forename: Jelle
authors.initials: J
authors.lastname: Praet
authors.forename: Kristien
authors.initials: K
authors.lastname: Reekmans
authors.forename: Debbie
authors.initials: D
authors.lastname: Le Blon
authors.forename: Chloé
authors.initials: C
authors.lastname: Hoornaert
authors.forename: Jasmijn
authors.initials: J
authors.lastname: Daans
authors.forename: Zwi
authors.initials: Z
authors.lastname: Berneman
authors.forename: Annemie
authors.initials: A
authors.lastname: Van der Linden
authors.forename: Peter
authors.initials: P
authors.lastname: Ponsaerts
mesh_terms: D002490:Central Nervous System; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000473:pathology / Q000502:physiology*