title: Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors.
abstract: Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular infl ammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), signifi cantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective GABAA receptor antagonist) and WAY 100635 (a selective 5-HT1A receptor antagonist). Taken together, these fi ndings suggest that the anxiolytic-like effects of CWE might be mediated by the GABAA receptor and the 5-HT1A receptor.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Sa-Ik
authors.initials: SI
authors.lastname: Hong
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Kwon
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Shi-Xun
authors.initials: SX
authors.lastname: Ma
authors.forename: Je-Won
authors.initials: JW
authors.lastname: Kwon
authors.forename: Seung-Min
authors.initials: SM
authors.lastname: Choi
authors.forename: Soo-Im
authors.initials: SI
authors.lastname: Choi
authors.forename: Sun-Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Seok-Yong
authors.initials: SY
authors.lastname: Lee
authors.forename: Choon-Gon
authors.initials: CG
authors.lastname: Jang
keywords: 5-HT1A receptor; Anxiolytic-like effects; Chrysanthemum indicum Linne; Elevated plus maze; GABAA receptor