title: Novel biodegradable lamina for lamina repair and reconstruction.
abstract: BACKGROUND
  Posterior laminectomy is an effective spinal surgical procedure. The adhesion of postoperative scar tissue to surgically exposed dura and, occasionally, to nerve roots can cause failed back surgery syndrome. The establishment of a barrier between scar tissue and dura that is made of hard material may prevent scar adhesions.
  
  
  OBJECTIVE
  To evaluate the efficacy of a novel biodegradable multi-amino acid copolymer/nanohydroxyapatite composite artificial lamina.
  
  
  METHODS
  A cervical laminectomy animal model in goats was used, and the animals were randomly divided into three groups. In the test group, cervical 4 was removed by laminectomy and the artificial lamina was inserted (n=12). In the control group, the incision was closed directly without implantation (n=9). The goats in the normal group did not undergo any procedure or treatment. Copolymer efficiency was tested by using X-ray, computed tomography scanning, magnetic resonance imaging, scanning electronic microscope, and histologic and biomechanical measurements 4, 12, and 24 weeks postoperation.
  
  
  RESULTS
  No shifting of the artificial lamina or dural adhesion pressure was observed. New cervical natural bone formed in the defect and the bony spinal canal was rebuilt. In the control group, fibrous scar tissue filled the defect and exerted pressure on the dura. No paralysis was observed, and gait was normal in all test and control goats.
  
  
  CONCLUSIONS
  Artificial lamina can prevent the epidural adhesions surrounding the defect and promote effectively bone tissue repair and new bone formation.
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, NO. 37 Guoxuexiang Rd, Wuhou District, Chengdu 610041, China; Jining NO. 1 People's Hospital, NO. 6 Jiankang Rd, Central District, Jining City, Shandong Province 272002, China.
authors.forename: Chaoliang
authors.initials: C
authors.lastname: Lv
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Zhou
authors.forename: Yueming
authors.initials: Y
authors.lastname: Song
authors.forename: Limin
authors.initials: L
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Quan
authors.initials: Q
authors.lastname: Gong
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Jiancheng
authors.initials: J
authors.lastname: Zeng
authors.forename: Chongqi
authors.initials: C
authors.lastname: Tu
authors.forename: Fuxing
authors.initials: F
authors.lastname: Pei
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D004388:Dura Mater / Q000187:drug effects; D006041:Goats; D006882:Hydroxyapatites / Q000494:pharmacology*; D007796:Laminectomy / Q000009:adverse effects*; D008297:Male; D013118:Spinal Cord Diseases / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites
keywords: Adhesions; Artificial lamina; Goats; Lamina reconstruction