title: Secondary bilateral striopallidodentate calcinosis associated with generalized pustular psoriasis (Von Zumbusch).
abstract: Bilateral striopallidodentate calcinosis (BSPDC) mentioned in the literature as Fahr's disease (a misnomer), is characterized by symmetrical and bilateral intracerebral calcifications located in the basal ganglia with or without deposits in the dentate nucleus, thalamus, and white matter. This entity is usually asymptomatic but may be manifested by neurological symptoms. Idiopathic BSPDC can occur either as sporadic or autosomal dominant familial forms. Secondary presentations of BSPDC are associated with infections, neoplastic diseases, toxicological or traumatic factors, and metabolic disorders. We describe a case of generalized pustular psoriasis associated with secondary BSPDC owing to pseudohypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a normal serum level of parathormone. The correction of the phosphorus-calcium metabolism disorder produced clinical improvement.
authors.affiliation: Serviço de Dermatologia, Hospital de Santa Maria- Centro Hospitalar Lisboa Norte. pachecocas@hotmail.com
authors.forename: David
authors.initials: D
authors.lastname: Pacheco
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Travassos
authors.forename: Joana
authors.initials: J
authors.lastname: Antunes
authors.forename: Manuel Sacramento
authors.initials: MS
authors.lastname: Marques
authors.forename: Paulo
authors.initials: P
authors.lastname: Filipe
authors.forename: Raquel
authors.initials: R
authors.lastname: Silva
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy; D001480:Basal Ganglia Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D002118:Calcium / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000150:complications; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy / Q000209:etiology; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D009263:Nails, Ingrown / Q000601:surgery; D019636:Neurodegenerative Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D011183:Postoperative Complications / Q000209:etiology; D011547:Pseudohypoparathyroidism / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011565:Psoriasis / Q000188:drug therapy / Q000209:etiology*; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D005436:Floxacillin; D017255:Acitretin; D002118:Calcium