title: [Intrinsic radiosensitivity: predictive assays that will change daily practice].
abstract: The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better understand the mechanisms of radiation-induced late effects. We also present the possibilities of clinical use of predictive assays in the close future.
authors.affiliation: Institut de recherche en cancérologie de Montpellier (IRCM), Inserm U896, avenue des Apothicaires, 34298 Montpellier cedex 05, France; Avenue des Apothicaires, 34298 Montpellier cedex 05, France; Université Montpellier 1, avenue des Apothicaires, 34298 Montpellier cedex 05, France.
authors.forename: J
authors.initials: J
authors.lastname: Lacombe
authors.forename: O
authors.initials: O
authors.lastname: Riou
authors.forename: J
authors.initials: J
authors.lastname: Solassol
authors.forename: A
authors.initials: A
authors.lastname: Mangé
authors.forename: C
authors.initials: C
authors.lastname: Bourgier
authors.forename: P
authors.initials: P
authors.lastname: Fenoglietto
authors.forename: A
authors.initials: A
authors.lastname: Pèlegrin
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.forename: D
authors.initials: D
authors.lastname: Azria
mesh_terms: D017209:Apoptosis; D002478:Cells, Cultured / Q000528:radiation effects; D005347:Fibroblasts / Q000528:radiation effects; D005838:Genotype; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D040901:Proteomics; D011832:Radiation Injuries / Q000235:genetics; D011836:Radiation Tolerance / Q000235:genetics* / Q000502:physiology*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage
keywords: Effets indésirables; Late effects; Predictive assays; Radiotherapy; Radiothérapie; Tests radiosensibilité