title: Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.
abstract: New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , CH-8093 Zürich, Switzerland, and Discovery Research, Chemistry Technologies & Innovation, F. Hoffmann-La Roche AG , CH-4070 Basel, Switzerland.
authors.forename: Dong Bo
authors.initials: DB
authors.lastname: Li
authors.forename: Mark
authors.initials: M
authors.lastname: Rogers-Evans
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D000818:Animals; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D055808:Drug Discovery; D015394:Molecular Structure; D009795:Octanes / Q000138:chemical synthesis* / Q000737:chemistry; D010121:Oxytocin / Q000031:analogs & derivatives; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D009795:Octanes; D013141:Spiro Compounds; D010121:Oxytocin; C015692:oxytocin, Asp(5)-