title: [The hepatoprotective activity of remaxol and S-adenosyl-L-methionine for liver damage caused by reserve-series antituberculosis drugs].
abstract: Experiments on male albino outbred rats investigated the hepatoprotective activity of remaxol and ademethionine in liver damage caused by reserve-series antituberculosis drugs. The test drugs had a mixed action, by reducing the degree of cytolytic and cholestatic syndromes. Remaxol and ademethionine assist in diminishing the degree of liver structural and functional impairments occurring with reserve-series antituberculosis drugs, by restoring the girder structure of lobes and decreasing the magnitude of dystrophic changes to stimulate reparative processes. Histological examination of liver tissue sections from rats receiving ademethionine revealed the enhanced activity of alterative processes in the liver.
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: T I
authors.initials: TI
authors.lastname: Vinogradova
authors.forename: N V
authors.initials: NV
authors.lastname: Zabolotnykh
authors.forename: S N
authors.initials: SN
authors.lastname: Vasil'eva
authors.forename: M L
authors.initials: ML
authors.lastname: Vitovskaia
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D008297:Male; D051381:Rats; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; C555877:Remaxol; D013386:Succinates; D012436:S-Adenosylmethionine