title: The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association of SOX2 expression in tumor with clinicopathological features and survival of non-small-cell lung carcinoma (NSCLC) patients.
  
  
  METHODS
  Publications assessing the clinicopathological characteristics and prognostic significance of SOX2 in NSCLC were identified up to May 2013. A meta-analysis of eligible studies was performed using standard statistical methods to clarify the association between SOX2 expression and these clinical parameters.
  
  
  RESULTS
  A total of eight studies met the inclusion criteria. Analysis of these data showed that SOX2 expression was positively associated with squamous histology, (pooled OR = 5.26, 95% CI: 1.08-25.6, P = 0.040). Simultaneously, we also found that SOX2 expression was positively associated with overall survival (pooled HR = 0.65, 95% CI: 0.47-0.89, P = 0.007, random-effect).
  
  
  CONCLUSIONS
  SOX2 expression in tumor is a candidate positive prognostic biomarker for NSCLC patients.
authors.affiliation: Department of Molecular Cell Biology and Toxicology, Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Yansu
authors.initials: Y
authors.lastname: Chen
authors.forename: Yefei
authors.initials: Y
authors.lastname: Huang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Huang
authors.forename: Junjie
authors.initials: J
authors.lastname: Chen
authors.forename: Shouyu
authors.initials: S
authors.lastname: Wang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhou
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors