title: In vitro antioxidant and antitumor activities of different sulfated polysaccharides isolated from three algae.
abstract: Three sulfated polysaccharides(Ulva fasciata (UFP), Gloiopeltis furcata (GFP), Sargassum henslouianum (SHP))were isolated from three algae including green alga Ulva fasciata, red alga Gloiopeltis furcata and brown alga Sargassum henslouianum by ultrasonic extraction and radial flow chromatography. Their in vitro antioxidant and antitumor activities were investigated and compared. Among these three polysaccharides, UFP, with relatively lower sulfate content, exhibited excellent antioxidant activities in superoxide radical assay, ABTS assay and DPPH assay; however, it demonstrated the minimal inhibitory effects on growth of MKN45 gastric cancer cells and DLD intestinal cancer cells. SHP with the lowest sulfate content gained relatively lower radical scavenging rates but showed significantly higher antitumor activities. These results indicated that the in vitro antitumor and antioxidant activities of the three polysaccharides may be related to combined effects of sulfate content and uronic acid content.
authors.affiliation: Department of Food Science and Engineering, College of Biological and Environmental Engineering, Zhejiang University of Technology, Zhejiang Hangzhou 310014, PR, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Shao
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Chen
authors.forename: Peilong
authors.initials: P
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D000461:Rhodophyta / Q000737:chemistry*; D044647:Sargassum / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D044445:Ulva / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D011134:Polysaccharides; D013431:Sulfates
keywords: Antioxidant activity; Antitumor activity; Sulfated polysaccharide