title: Blends of jackfruit seed starch-pectin in the development of mucoadhesive beads containing metformin HCl.
abstract: In this work, calcium pectinate-jackfruit (Artocarpus heterophyllus Lam.) seed starch (JFSS) mucoadhesive beads containing metformin HCl were developed through ionotropic-gelation. Effects of pectin and JFSS amounts on drug encapsulation efficiency (DEE), and cumulative drug release after 10 h (R10 h) were optimized using 3(2) factorial design. The optimized calcium pectinate-JFSS beads containing metformin HCl showed DEE of 94.11 ± 3.92%, R10 h of 48.88 ± 2.02%, and mean diameter of 2.06 ± 0.20 mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The pH of test mediums was found critical for swelling and mucoadhesion of these beads. The optimized calcium pectinate-JFSS beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
mesh_terms: D000268:Adhesiveness; D000818:Animals; D031622:Artocarpus / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D007413:Intestinal Mucosa / Q000737:chemistry*; D008297:Male; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010368:Pectins; D013213:Starch; D008687:Metformin
keywords: Drug release; Ionotropic-gelation; Jackfruit seed starch; Mucoadhesion; Pectin; Polymer-blend