title: Five new degraded diterpenoids from Trigonostemon xyphophylloides.
abstract: Five new degraded diterpenoids trigoxyphins J-N (1-5), among them trigoxyphins K and L have a novel carbon skeleton, together with four known analogues (6-9) have been obtained from the ethanol extract of the twigs of Trigonostemon xyphophylloides. Compounds 1-5 were evaluated for their cytotoxic activity in vitro against three human tumor cell lines by MTT assay. The results exhibited that Trigoxyphin N (5) showed moderate cytotoxicities against SPC-A-1 and SGC-7901 cancer cell lines.
authors.affiliation: School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yang
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.forename: Liu-Qing
authors.initials: LQ
authors.lastname: Yang
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wu
authors.forename: Chang-Ri
authors.initials: CR
authors.lastname: Han
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Chen
authors.forename: Bing-Yan
authors.initials: BY
authors.lastname: Zou
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D019665:Euphorbiaceae / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts
keywords: Chemical constituents; Cytotoxic activities; Trigonostemon; Trigonostemon xyphophylloide