title: Intravenous iron sucrose for restless legs syndrome in pregnant women with low serum ferritin.
abstract: We report on two pregnant women who either had de novo restless legs syndrome (RLS) or had marked enhancement of preexisting RLS symptoms during pregnancy. Both patients had ferritin values <50 μg/L at baseline. The patients had relevant sleep disorders and daytime symptoms caused by RLS. The women were treated in an open paradigm with intravenous iron sucrose. A few weeks after therapy, both patients experienced a significant reduction or even remission of RLS symptoms. Their quality of life and sleep substantially improved and no treatment-related adverse effects were observed. According to our initial experience, intravenous iron sucrose administration appears to be an effective therapy in RLS patients with low ferritin values during pregnancy.
authors.affiliation: Philipps-University Marburg, Department of Neurology, Marburg, Germany. Electronic address: vadaszdavid@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Vadasz
authors.forename: Vincent
authors.initials: V
authors.lastname: Ries
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage*; D000077605:Ferric Oxide, Saccharated; D005293:Ferritins / Q000097:blood / Q000172:deficiency*; D005937:Glucaric Acid / Q000008:administration & dosage*; D006397:Hematinics / Q000008:administration & dosage; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000378:metabolism; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D005290:Ferric Compounds; D006397:Hematinics; D005293:Ferritins; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid
keywords: Ferritin; Intravenous iron sucrose; Pregnancy; Restless legs syndrome; Treatment attempt