title: The effect of synovectomy on bleeding and clinical outcomes for total knee replacement.
abstract: A total of 187 patients with primary osteoarthritis (OA) of the knee undergoing total knee replacement (TKR) were randomly divided into two groups, one of which underwent synovectomy. The patients and assessors were blinded to the randomisation both before and after surgery. The duration of surgery, hospitalisation period, concealed bleeding, drainage volume, blood transfusion rate and range of movement of the knee at three days after the operation were analysed. Patients were followed up at four weeks and 12 months after their operation, and a visual analogue score (VAS) for pain, Knee Society score (KSS) and a patellar ballottement test were compared between the groups. The mean amount of concealed bleeding was higher in the synovectomy group compared with the control group (1.24 l (0.08 to 3.28) vs 1.03 l (0.16 to 2.94); p = 0.042), as was the mean drainage volume (0.90 l (0.35 to 1.81) vs 0.81 (0.25 to 1.65); p = 0.030). The mean operating time was also higher in the synovectomy group compared with the controls (1.50 hours (1.34 to 1.75) vs 1.41 hours (1.21 to 1.79); p = 0.006). There were no significant differences in blood transfusion rate (p = 0.882), hospital stay (p = 0.805) or range of movement of the knee (p = 0.413) between the two groups. At four weeks and 12 months post-operatively there were no statistically significant differences in any of the measured parameters. We concluded that synovectomy confers no clinical advantages in TKR for primary OA while subjecting patients to higher levels of bleeding and longer operating times.
authors.affiliation: Affiliated Hospital of Qingdao University Medical College, Department of Articular Surgery, 16 Jiangsu street, Qingdao, Shandong, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhaoning
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Shaoqi
authors.forename: H
authors.initials: H
authors.lastname: Baiqiang
authors.forename: S
authors.initials: S
authors.lastname: Kang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000209:etiology; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D001803:Blood Transfusion / Q000706:statistics & numerical data; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000601:surgery*; D016059:Range of Motion, Articular / Q000502:physiology; D000074402:Synovectomy; D016896:Treatment Outcome
keywords: Knee joint; Osteoarthritis; Replacement; Synovectomy; Synovial membrane; TKR