title: Picture perfect: DNA-templated photoaffinity labeling.
abstract: Just so far apart and no further: Small molecules target ID by DNA tagging. Nucleic acid hybridization has been used to pair a photo-crosslinking group with a small molecule of interest. Following photoactivation, the protein(s) interacting with the small molecule are covalently linked to a nucleic acid tag.
authors.affiliation: Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva (Switzerland).
authors.forename: Sofia
authors.initials: S
authors.lastname: Barluenga
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D019920:Photoaffinity Labels / Q000737:chemistry*
chemical_list: D019920:Photoaffinity Labels; D004247:DNA
keywords: DNA; photo-crosslinking; small molecules