title: Apparent treatment-resistant hypertension among elderly Korean hypertensives: an insight from the HIT registry.
abstract: The aim of this study was to determine the clinical characteristics of patients with resistant hypertension (RH) and predictors among elderly Korean hypertensives. This prospective, multi-center, observational study evaluated 2439 elderly hypertensive patients between December 2008 and November 2011, who visited secondary hypertension clinics for high blood pressure (BP). Patients were categorized as resistant if their BP was ≥140/90 mm Hg and if they reported using antihypertensive medications from three different drug classes, including a diuretic or drugs from ≥4 antihypertensive drug classes, regardless of BP. Characteristics of patients with RH were compared with those of patients who were controlled with one or two antihypertensive medications after 6-month antihypertensive treatment. In comparison with 837 patients with non-RH, 404 patients with RH were more likely to be aware of their status of high BP before enrollment and have a high baseline systolic BP ≥160 mm Hg, microalbuminuria, high body mass index (BMI) ≥24 kg m(-2) and diabetes mellitus (DM). In drug-naive patients, awareness of hypertension at baseline was the only independent predictor for RH. In elderly Korean hypertensives, BMI (≥24 kg m(-2)), baseline systolic BP (≥160 mm Hg), microalbuminuria, DM and awareness of hypertension showed an association with RH.
authors.affiliation: Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong, Korea.
authors.forename: S-W
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong, Korea.
authors.forename: M-K
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Hangang Sacred Heart Hospital, Hallym University, Seoul, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Han
authors.affiliation: Division of Cardiology, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Han
authors.affiliation: Division of Cardiology, Gangnam Severance Hospital, Yonsei University, Seoul, Korea.
authors.forename: B K
authors.initials: BK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gwangju Christian Hospital, Gwangju, Korea.
authors.forename: S U
authors.initials: SU
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Hur
authors.affiliation: Division of Cardiology, Bundang Cha Hospital, Cha University, Seongnam, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Lim
authors.affiliation: Division of Cardiology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
authors.forename: K W
authors.initials: KW
authors.lastname: Moon
authors.affiliation: Division of Cardiology, Ulsan University Hospital, Ulsan, Korea.
authors.forename: S G
authors.initials: SG
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Dongkang Medical Center, Ulsan, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Wonkwang University School of Medicine and Hospital, Iksan, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Oh
authors.affiliation: Division of Cardiology, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: J G
authors.initials: JG
authors.lastname: Chea
authors.affiliation: Division of Cardiology, Jeju National University Hospital, Jeju, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Joo
authors.affiliation: Division of Cardiology, Chungbuk National University Hospital, Cheongju, Korea.
authors.forename: M C
authors.initials: MC
authors.lastname: Jo
authors.affiliation: Division of Cardiology, Chooncheon Sacred Heart Hospital, Hallym University, Chooncheon, Korea.
authors.forename: K-S
authors.initials: KS
authors.lastname: Hong
authors.affiliation: Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong, Korea.
authors.forename: K-H
authors.initials: KH
authors.lastname: Ryu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents