title: Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs.
abstract: Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.
authors.affiliation: Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology), Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Ti
authors.initials: T
authors.lastname: Wen
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Zhenzhou
authors.initials: Z
authors.lastname: Wu
authors.forename: Puyue
authors.initials: P
authors.lastname: Wang
authors.forename: Zhangyong
authors.initials: Z
authors.lastname: Hong
authors.forename: Liqing
authors.initials: L
authors.lastname: Zhao
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Richard
authors.initials: R
authors.lastname: Flavell
authors.forename: Shumei
authors.initials: S
authors.lastname: Gao
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Yin
mesh_terms: D000818:Animals; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D007249:Inflammation / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020871:RNA Stability / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018418:Th2 Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D047309:Flavones
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D050990:GATA3 Transcription Factor; D012333:RNA, Messenger; C494748:Gata3 protein, mouse; C468752:bavachinin; D047309:Flavones