title: [Antisynthetase syndrome - a case report].
abstract: Twenty-eight year-old woman with predominant signs of polymyositis, pulmonary interstitium involvement and with positive anti-Jo1 antibodies was suspected for antisynthetase syndrome. Over the next three months sores and ulcerations have appeared at the fingertips. In the later course of the disease clinical picture of mixed connective tissue disease associated with interstitial lung disease, with a dominant picture of systemic sclerosis have emerged. She was treated with glucocorticoides and immunosuppressive therapy. Patient condition was mostly stable, without significant progression of lung lesions. Early diagnosis and treatment antisynthetase syndrome significantly contributes to more favorable course and outcome of disease. A prerequisite for that are well-defined diagnostic criteria and an appropriate choice of treatment.
authors.affiliation: Klinika za unutarnje bolesti, Klinicki bolnicki centar Osijek. prus1@net.hr
authors.forename: Visnja
authors.initials: V
authors.lastname: Prus
authors.forename: Drazen
authors.initials: D
authors.lastname: Bedeković
authors.forename: Jasminka
authors.initials: J
authors.lastname: Milas-Ahić
authors.forename: Roberta
authors.initials: R
authors.lastname: Visević
authors.forename: Branko
authors.initials: B
authors.lastname: Segec
authors.forename: Zlatica
authors.initials: Z
authors.lastname: Jukić
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Perić
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D009220:Myositis / Q000000981:diagnostic imaging* / Q000276:immunology / Q000628:therapy; D011859:Radiography
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; C046750:Jo-1 antibody