title: Impact of donor and recipient age difference on long-term allograft survival after living donor renal transplantation: analysis of 478 cases.
abstract: BACKGROUND
  Either deceased or living-related renal transplantation constitutes the best therapeutic option for patients with end-stage renal disease. In this retrospective study, an attempt to identify parameters that affect allograft survival in living donor renal transplantation was made.
  
  
  METHODS
  Between January 2000 and July 2012, 478 adult patients received a renal transplant from a living-related donor in our center and their records were retrospectively reviewed in November 2012. Data concerning donor age, recipient age, donor/recipient age difference, donor/recipient gender, and ABO compatibility/incompatibility were recorded and associated with renal allograft survival rate.
  
  
  RESULTS
  Renal allograft survival rate was 96%, 89.5%, and 77.7% in the first, fifth, and 10th yr after transplantation, respectively. Only the difference between donor and recipient age was statistically significant in relation to graft survival. In cases with age difference >13 yr, graft survival rate was lower from the third yr onward.
  
  
  CONCLUSIONS
  Only the age difference between donor and recipient exerts an adverse impact on graft outcome after living donor renal transplantation, whereas donor age, recipient age, donor/recipient gender, and ABO incompatibility do not significantly influence renal allograft survival.
authors.affiliation: Transplantation Unit, "Laiko" General Hospital, Athens, Greece.
authors.forename: Ioannis D
authors.initials: ID
authors.lastname: Kostakis
authors.forename: Demetrios N
authors.initials: DN
authors.lastname: Moris
authors.forename: Alexandros
authors.initials: A
authors.lastname: Barlas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Bokos
authors.forename: Maria
authors.initials: M
authors.lastname: Darema
authors.forename: Eleni
authors.initials: E
authors.lastname: Theodoropoulou
authors.forename: Georgios
authors.initials: G
authors.lastname: Karaolanis
authors.forename: Alkiviadis
authors.initials: A
authors.lastname: Kostakis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Boletis
authors.forename: Georgios
authors.initials: G
authors.lastname: Zavos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D064591:Allografts; D001787:Blood Group Incompatibility; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: age difference; living donor; renal allograft survival; renal transplantation