title: Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones.
abstract: 2,4-Dimethylbenzoylhydrazones 1-30 were synthesized by condensation reactions of 2,4-dimethylbenzoylhydrazide with various aromatic aldehydes and characterized. The assigned structures of compounds 10, 15 and 22 were further supported by single-crystal X-ray diffraction data. The synthesized compounds were evaluated for their in vitro DPPH radical scavenging activity. They exerted varying degree of scavenging activity toward DPPH radical with IC₅₀ values between 25.6-190 µM. Compounds 1, 4, 2, 3, 7, and 6 have IC₅₀ values of 25.6, 28.1, 29.3, 29.8, 30.0 and 30.1 µM respectively, showing better activity than an n-propyl gallate standard (IC₅₀ value = 30.30 µM). For super oxide anion scavenging activity compounds 1, 2 and 3 with IC₅₀ values of 98.3, 102.6, and 105.6, respectively, also showed better activity than the n-propyl gallate standard (IC₅₀ value = 106.34 µM).
authors.affiliation: Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia. taha_hej@yahoo.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Nor Hadiani
authors.initials: NH
authors.lastname: Ismail
authors.forename: Waqas
authors.initials: W
authors.lastname: Jamil
authors.forename: Sammer
authors.initials: S
authors.lastname: Yousuf
authors.forename: Faridahanim Mohd
authors.initials: FM
authors.lastname: Jaafar
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Ali
authors.forename: Syed Muhammad
authors.initials: SM
authors.lastname: Kashif
authors.forename: Ejaz
authors.initials: E
authors.lastname: Hussain
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D016166:Free Radical Scavengers / Q000138:chemical synthesis*; D006835:Hydrazones / Q000138:chemical synthesis*; D010851:Picrates / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006835:Hydrazones; D010851:Picrates; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl