title: Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors.
abstract: A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.
authors.affiliation: Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri, 63130, USA.
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Shen
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Fuwu
authors.initials: F
authors.lastname: Zhang
authors.forename: Alexander
authors.initials: A
authors.lastname: Loftis
authors.forename: Adriana
authors.initials: A
authors.lastname: Pavía-Sanders
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Jingwei
authors.initials: J
authors.lastname: Fan
authors.forename: John-Stephen A
authors.initials: JS
authors.lastname: Taylor
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley
mesh_terms: D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004952:Esters; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D011108:Polymers; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II
keywords: degradation; iNOS inhibition; integrated construction; polyphosphoester-based nanoparticle