title: Resolution of gelatinous bone marrow transformation following hormone replacement therapy in a patient with primary insufficiency of the adrenal and thyroid glands.
abstract: A 59-year-old man with recurrent oral cancer presented with severe pancytopenia, hyponatremia and hypoglycemia. Endocrine testing showed a partial primary adrenal insufficiency and primary hypothyroidism. The bone marrow biopsy showed a gelatinous transformation with hypocellularity and fat atrophy. His pancytopenia, hyponatremia and hypoglycemia resolved following treatment with corticosteroids and thyroid hormone replacement therapy. The follow-up bone marrow biopsy demonstrated a resolution of the gelatinous transformation. This case is a rare example of a patient with a primary insufficiency of the adrenal and thyroid glands that is associated with gelatinous bone marrow transformation (GMT). The GMT was resolved through the administration of corticosteroids and thyroid hormone replacement therapy.
authors.affiliation: Department of Endocrinology and Metabolism, Sumitomo Hospital, Japan. yoshinari0811@hotmail.co.jp
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Obata
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tamba
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yamada
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Kyo
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Takahi
authors.forename: Kenji
authors.initials: K
authors.lastname: Saisho
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Yamato
authors.forename: Kenji
authors.initials: K
authors.lastname: Hattori
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ujiie
authors.forename: Shigeki
authors.initials: S
authors.lastname: Fujita
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000224:Addison Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D001855:Bone Marrow Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged