title: Evaluation of the Influence of thiosemicarbazone-triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents.
abstract: A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired.
authors.affiliation: Department of Chemistry, University of Johannesburg, Auckland park 2006, South Africa. hhkinfe@uj.ac.za
authors.forename: Henok H
authors.initials: HH
authors.lastname: Kinfe
authors.forename: Yonas H
authors.initials: YH
authors.lastname: Belay
authors.forename: Jitcy S
authors.initials: JS
authors.lastname: Joseph
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mukwevho
mesh_terms: D019440:Anti-Obesity Agents / Q000737:chemistry / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D019440:Anti-Obesity Agents; D013844:Thiazoles; D013882:Thiosemicarbazones
keywords: Diabetics; Lipid; Obesity; Thiosemicarbazon–triazole hybrid