title: Association of polymorphism in rs2736990 of the α-synuclein gene with Parkinson's disease in a Chinese population.
abstract: OBJECTIVE
  Previous genetic studies in Parkinson's disease (PD) have provided conclusive evidence for association of genes with strong biological rationale for PD. Recently several studies in different populations have found a strong association between idiopathic PD and the single-nucleotide polymorphism (SNP) rs2736990, located within an intron of the α-synuclein (SNCA) gene. In this study, we aimed to verify these findings and to explore the characteristic of the association in a subset of Chinese Han PD patients.
  
  
  METHODS
  A total of 515 unrelated patients with sporadic PD and 450 healthy ethnically matched control subjects were recruited consecutively for the study. Patients and healthy controls were genotyped for SNCA rs2736990 variant by polymerase chain reaction - ligase detection reaction.
  
  
  RESULTS
  Our data showed a significant association between the rs2736990 polymorphism and PD, the frequency of the allele C in PD patients was significantly higher than that in controls (P = 0.017, OR = 1.26, 95% confident intervals (CI) =1.04-1.51). The distribution of C > T genotypes was different between patients and controls (P = 0.027). Furthermore, allele C of SNP rs2736990 in early-onset PD was significantly more frequent than that in healthy controls (P = 0.007, odds ratio = 1.60, 95% CI = 1.13-2.26).
  
  
  CONCLUSIONS
  Our study demonstrated that SNCA rs2736990 C > T polymorphism was associated with susceptibility to PD in Chinese Han population. Further studies are needed to replicate the association we found.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210029, People's Republic of China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Pan
authors.forename: Haixia
authors.initials: H
authors.lastname: Ding
authors.forename: Hairong
authors.initials: H
authors.lastname: Dong
authors.forename: Min
authors.initials: M
authors.lastname: Ye
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.forename: Guiyun
authors.initials: G
authors.lastname: Cui
authors.forename: Jiechun
authors.initials: J
authors.lastname: Chen
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xingzhen
authors.initials: X
authors.lastname: Dai
authors.forename: Haicun
authors.initials: H
authors.lastname: Shi
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D051844:alpha-Synuclein