title: Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study.
abstract: OBJECTIVE
  to determine the prevalence of restless legs syndrome (RLS) in a cohort of patients with demyelinating neuropathies.
  
  
  METHODS
  Patients were retrospectively recruited from our cohort of different forms of demyelinating neuropathies, including chronic inflammatory demyelinating neuropathy (CIDP), Charcot-Marie-Tooth 1A (CMT1A), and hereditary neuropathy with liability to pressure palsies (HNPP) referred to our Department of Neurology in a 10-year period. The validated 4-item RLS questionnaire was used for diagnosis of RLS. All patients with RLS who fulfilled criteria underwent a suggested immobilization test to confirm the diagnosis. A group of outpatients referred to the sleep disorders unit and data from published literature were used as controls.
  
  
  RESULTS
  Prevalence of RLS in demyelinating neuropathy group was higher than prevalence observed in control population (p = 0.0142) or in the literature data (p = 0.0007). In particular, in comparison with both control population and literature data, prevalence of RLS was higher in CIDP group (p = 0.0266 and p = 0.0063, respectively) and in CMT1A group (p = 0.0312 and p = 0.0105, respectively), but not in HNPP (p = 1.000 and p = 0.9320, respectively).
  
  
  CONCLUSIONS
  our study confirms a high prevalence of RLS in inflammatory neuropathies as CIDP and, among inherited neuropathies, in CMT1A but not in HNPP. Considering that this is only a small cohort from a single-center retrospective experience, the link between RLS and neuropathy remains uncertain, and larger multicenter studies are probably needed to clarify the real meaning of the association between RLS and neuropathy.
authors.affiliation: Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy. mluigetti@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Luigetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Del Grande
authors.forename: Elisa
authors.initials: E
authors.lastname: Testani
authors.forename: Giulia
authors.initials: G
authors.lastname: Bisogni
authors.forename: Anna
authors.initials: A
authors.lastname: Losurdo
authors.forename: Nadia Mariagrazia
authors.initials: NM
authors.lastname: Giannantoni
authors.forename: Salvatore
authors.initials: S
authors.lastname: Mazza
authors.forename: Mario
authors.initials: M
authors.lastname: Sabatelli
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001176:Arthrogryposis / Q000150:complications; D002607:Charcot-Marie-Tooth Disease / Q000150:complications; D003711:Demyelinating Diseases / Q000150:complications*; D005260:Female; D015417:Hereditary Sensory and Motor Neuropathy / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000209:etiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Charcot-Marie-Tooth 1A (CMT1A); Restless leg syndrome (RLS); chronic inflammatory demyelinating neuropathy (CIDP); demyelinating neuropathies; hereditary neuropathy with liability to pressure palsies (HNPP); suggested immobilization test (SIT)