title: Postcholecystectomy bile duct injury and its sequelae: pathogenesis, classification, and management.
abstract: A bile duct injury sustained during cholecystectomy can change the life of patients who submit themselves to a seemingly innocuous surgery. It has far-reaching medical, socioeconomic, and legal ramifications. Attention to detail, proper interpretation of variant anatomy, use of intraoperative cholangiography, and conversion to an open procedure in cases of difficulty can avoid/lessen the impact of some of these injuries. Once suspected, the aims of investigation are to establish the type and extent of injury and to plan the timing and mode of intervention. The principles of treatment are to control sepsis and to establish drainage of all liver segments with minimum chances of restricturing. Availability of expertise, morbidity, mortality, and quality of life issues dictate the modality of treatment chosen. Endoscopic intervention is the treatment of choice for minor leaks and provides outcomes comparable to surgery in selected patients with lateral injuries and partial strictures. A Roux-en-Y hepaticojejunostomy (HJ) by a specialist surgeon is the gold standard for high strictures, complete bile duct transection and has been shown to provide excellent long-term outcomes. Percutaneous intervention is invaluable in draining bile collections and is useful in treating post-HJ strictures. Combined biliovascular injuries, segmental atrophy, and secondary biliary cirrhosis with portal hypertension are special circumstances which are best managed by a multidisciplinary team at an experienced center for optimal outcomes.
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, 110 070, India.
authors.forename: Kishore G S
authors.initials: KG
authors.lastname: Bharathy
authors.forename: Sanjay S
authors.initials: SS
authors.lastname: Negi
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods; D001652:Bile Ducts / Q000293:injuries* / Q000601:surgery; D002758:Cholangiography; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D004322:Drainage; D016145:Endoscopy, Digestive System; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D007049:Iatrogenic Disease / Q000517:prevention & control*; D007582:Jejunostomy / Q000379:methods; D008099:Liver; D008105:Liver Cirrhosis, Biliary / Q000209:etiology; D011788:Quality of Life; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology / Q000517:prevention & control; D025321:Surgery, Computer-Assisted