title: Cell-based methods for the identification of MYC-inhibitory small molecules.
abstract: Oncoproteins encoded by dominant oncogenes have long been considered as targets for chemotherapeutic intervention. However, oncogenic transcription factors have often been dismissed as "undruggable." Members of Myc family of transcription factors have been identified as promising targets for cancer chemotherapy in multiple publications reporting the requirement of Myc proteins for maintenance of almost every type of tumor. Here, we describe cell-based approaches to identify c-Myc small molecule inhibitors by screening complex libraries of diverse small molecules based on Myc functionality and specificity.
authors.affiliation: Cleveland BioLabs, Inc., Buffalo, NY, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Burkhart
authors.forename: Michelle
authors.initials: M
authors.lastname: Haber
authors.forename: Murray D
authors.initials: MD
authors.lastname: Norris
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Gudkov
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Nikiforov
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D015870:Gene Expression; D017930:Genes, Reporter; D006801:Humans; D010641:Phenotype; D016271:Proto-Oncogene Proteins c-myc / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries
chemical_list: D000970:Antineoplastic Agents; D016271:Proto-Oncogene Proteins c-myc; D054852:Small Molecule Libraries