title: Chronobiology in aortic diseases - "is this really a random phenomenon?".
abstract: Although acute aortic rupture or dissection is relatively uncommon, it ranks in third position among necropsy-confirmed causes of out-of-hospital sudden death in the general population. Similar to other acute cardiovascular events (e.g., acute myocardial infarction, sudden death, stroke, and pulmonary embolism) there is a growing body of evidence regarding temporal patterns in onset, characterized by circadian, seasonal and weekly variations for aortic aneurysms. On one hand, it is possible that these cardiovascular diseases share common underlying pathophysiologic mechanisms, e.g., increase in blood pressure, heart rate, sympathetic activity, basal vascular tone, vasoconstrictive hormones, and prothrombotic tendency. On the other hand, the possibility exists that the connecting link is an internal disruption (dyssynchrony) of some molecular mechanisms intrinsic to the peripheral biological clock (that of cardiomyocyte is the most widely investigated). Such disruption may contribute to cardiovascular disease and biological rhythms - an intriguing hypothesis for future research.
authors.affiliation: Clinica Medica, Department of Medical Sciences, University of Ferrara, Italy. roberto.manfredini@unife.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredini
authors.forename: Fabio
authors.initials: F
authors.lastname: Fabbian
authors.forename: Fabio
authors.initials: F
authors.lastname: Manfredini
authors.forename: Raffaella
authors.initials: R
authors.lastname: Salmi
authors.forename: Massimo
authors.initials: M
authors.lastname: Gallerani
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bossone
mesh_terms: D039602:After-Hours Care; D000784:Aortic Dissection / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D017545:Aortic Aneurysm, Thoracic / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D001019:Aortic Rupture / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D001683:Biological Clocks; D002940:Circadian Rhythm; D006801:Humans; D011379:Prognosis; D012307:Risk Factors; D012621:Seasons; D013997:Time Factors
keywords: Aortic aneurysm; Aortic aneurysm, abdominal; Aortic aneurysm, thoracic; Aortic rupture; BP; Blood pressure; Chronobiology; Circadian rhythm; IRAD; International Registry of Aortic Dissection; MI; MMPP; Matrix metalloproteinase; Myocardial infarction; PE; Pulmonary embolism; SCD; SCN; Seasons; Sudden cardiac death; TIA; TIMP; Tissue inhibitors of matrix metalloproteinase; Transient ischemic attack; suprachiasmatic nucleus