title: Serum amyloid A is independently related to apolipoprotein A-I but not to HDL-cholesterol in patients with angina pectoris.
abstract: BACKGROUND
  Inflammation processes are considered important links between classical lipid risk factors and the progression of atherosclerosis. The interrelationship of high density lipoproteins (HDL) and apolipoprotein apoA-1 with acute phase proteins and cytokines was examined in a clinical setting of patients with angina pectoris.
  
  
  METHODS
  On exclusion criteria (myocardial infarction, heart failure, CHD>2 years, anticoagulant therapy), 198 patients were recruited and were subdivided according to angiographically documented stenosis, no stenosis vs. =50% stenosis, in accordance with CASS guidelines. Lipids, apoA-1 and apoB, C-reactive protein (hs-CRP), fibrinogen, serum amyloid A (SAA) and cytokines (IL-6, IL-8, IL-10, IL2R, TNFα) were measured.
  
  
  RESULTS
  Low HDL-C (and apoA-I) is associated with advanced coronary stenosis (=50%) and with the number of diseased vessels, independent of age, gender, diabetes, smoking and lipid-lowering therapy. In contrast to hs-CRP and fibrinogen, SAA as well as cytokine levels were not significantly associated with stenosis. SAA (P=0.0003) and diabetes (P=0.0002) were strong predictors of apoA-I concentration independent of age, gender, BMI, smoking, CRP, as well as IL-6 in a multiple regression model. High SAA (P=0.0067) and TG (P=0.0123) were significant predictors of apoA-I/HDL-C ratio. However, SAA was not independently related to HDL-C.
  
  
  CONCLUSIONS
  SAA is independently and inversely related to apoA-I but not to HDL-C in patients with angina pectoris, reflecting the effect of SAA on the quality of HDL particles. However, HDL-c but not SAA is inversely related to the degree of coronary artery stenosis.
authors.affiliation: Laboratory Department, Faculty of Medicine, University Hospital Center "Mother Teresa", Tirana, Albania. Electronic address: irenakorita@yahoo.it.
authors.forename: Irena
authors.initials: I
authors.lastname: Korita
authors.forename: Anyla
authors.initials: A
authors.lastname: Bulo
authors.forename: Michel R
authors.initials: MR
authors.lastname: Langlois
authors.forename: Eline
authors.initials: E
authors.lastname: Verhoye
authors.forename: Victor
authors.initials: V
authors.lastname: Blaton
mesh_terms: D000787:Angina Pectoris / Q000097:blood* / Q000150:complications; D016632:Apolipoprotein A-I / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; D008076:Cholesterol, HDL; D000685:Serum Amyloid A Protein
keywords: Acute phase proteins; Apolipoprotein A-1; Coronary stenosis; Cytokines; High density lipoprotein; Serum amyloid A