title: MEX-3 proteins: recent insights on novel post-transcriptional regulators.
abstract: RNA-binding proteins of the evolutionarily-conserved MEX-3 family are mediators of post-transcriptional regulation in different organisms. Recent studies highlight their involvement in diverse physiological settings, including the maintenance of a balance between stem cell self-renewal and differentiation. Here, we draw attention to their putative role in tissue homeostasis and disease, particularly cancer.
authors.affiliation: IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, 4200-465 Porto, Portugal.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pereira
authors.forename: Mailys
authors.initials: M
authors.lastname: Le Borgne
authors.forename: Nicolas T
authors.initials: NT
authors.lastname: Chartier
authors.forename: Marc
authors.initials: M
authors.lastname: Billaud
authors.forename: Raquel
authors.initials: R
authors.lastname: Almeida
mesh_terms: D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; C102175:MEX-3 protein, C elegans; C515359:MEX3C protein, human; D016601:RNA-Binding Proteins; D012313:RNA
keywords: CDX2; MEX-3; RNA-binding protein; carcinogenesis; development; post-transcriptional regulation