title: [Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol].
abstract: Hepato- and endothelioprotective action of runihol and ademetionine in 66 male rats with liver disease induced by essential and second-line antituberculosis drugs in combination with alcohol were studied. One-directed affirmative action study drugs, shown to reduce the level of biochemical markers of cytolysis and cholestasis in conjunction with a significant reduction in symptoms of fatty, hyaline droplet and hydropic degeneration. In this runihol had a more pronounced anticytolitic effect, while under the influence of ademethionine the normalization endothelial dysfunction was established.
authors.affiliation: Northeastern State Medical University, St. Petersburg, Russia
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: E B
authors.initials: EB
authors.lastname: Artyushkova
authors.forename: V T
authors.initials: VT
authors.lastname: Dudka
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000633:toxicity*; D002779:Cholestasis / Q000188:drug therapy; D004727:Endothelium / Q000187:drug effects* / Q000473:pathology; D006818:Hyalin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D051381:Rats; D012436:S-Adenosylmethionine / Q000627:therapeutic use*
chemical_list: D000995:Antitubercular Agents; D012436:S-Adenosylmethionine