title: Effects of Xanthium stramarium and Psoralea corylifolia Extracts Combined with UVA1 Irradiation on the Cell Proliferation and TGF-β1 Expression of Keloid Fibroblasts.
abstract: BACKGROUND
  Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), phototoxic oriental medicinal plants, has been used in traditional medicines in Asian countries.
  
  
  OBJECTIVE
  The effects of highly purified XAS or PSC extract combined with ultraviolet A1 (UVA1) irradiation on cell proliferation and transforming growth factor-beta1 (TGF-β1) expression of the keloid fibroblast were being investigated to define potential therapeutic uses for keloid treatments.
  
  
  METHODS
  The keloid fibroblasts were treated with XAS or PSC alone or in the combination with UVA1 irradiation. The cell viability, apoptosis, and expression of TGF-β1 and collagen I were investigated.
  
  
  RESULTS
  XAS and PSC in combination with UVA1 irradiation suppressed cell proliferation and induced apoptosis of keloid fibroblasts. Furthermore, the XAS and PSC in combination with UVA1 irradiation inhibited TGF-β1 expression and collagen synthesis in keloid fibroblasts.
  
  
  CONCLUSIONS
  These findings may open up the possibility of clinically used XAS or PSC in combination with UVA1 irradiation for keloid treatments.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sun Yi
authors.initials: SY
authors.lastname: Park
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Park
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Sung Un
authors.initials: SU
authors.lastname: Kang
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Ki-Min
authors.initials: KM
authors.lastname: Bark
authors.forename: Tae Heung
authors.initials: TH
authors.lastname: Kim
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Shin
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Kang
keywords: Apoptosis; Keloid; Psoralea corylifolia; Transforming growth factor-beta 1; Xanthium stramarium