title: Prognostic values of osteopontin-c, E-cadherin and β-catenin in breast cancer.
abstract: OBJECTIVE
  To determine the correlation of cell adhesion molecules (osteopontin-c, E-cadherin and β-catenin) with clinicopathological characteristics in breast cancer.
  
  
  METHODS
  Immunostaining of osteopontin-c, E-cadherin and β-catenin were conducted in 170 samples of breast cancer and 30 samples of adjacent normal breast tissues. The correlation of osteopontin-c, E-cadherin and β-catenin expression level with clinicopathological characteristics was evaluated by Pearson's chi-square and Wilcoxon rank-sum test. Univariate and multivariate Cox hazard regression model was used to assess the prognostic values of osteopontin-c, E-cadherin and β-catenin in clinical outcome of breast cancer.
  
  
  RESULTS
  A higher level of osteopontin-c whereas lower levels of E-cadherin and β-catenin were observed in breast cancer as compared with the normal breast tissues. The expression of osteopontin-c was negatively associated with the expression of E-cadherin and β-catenin. The expression of osteopontin-c correlated with lymph node metastasis, and advanced TNM stage and histologic grade. The expression of E-cadherin correlated with low histologic grade; and β-catenin with low TNM stage and histological grade. Moreover, high osteopontin-c level correlated with tumor recurrence or metastasis as well as triple negative subtype. The expression of osteopontin-c was an independent prognostic factor for both disease-free and overall survival of breast cancer patients.
  
  
  CONCLUSIONS
  The data suggest that the expression of osteopontin-c could serve as a prognostic factor of breast cancer.
authors.affiliation: Department of Internal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Pang
authors.forename: Hailing
authors.initials: H
authors.lastname: Lu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Meng
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Lan
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Suhong
authors.initials: S
authors.lastname: Yan
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Dong
authors.forename: Li
authors.initials: L
authors.lastname: Cai
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001940:Breast / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015820:Cadherins / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D053495:Osteopontin / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin; D053495:Osteopontin
keywords: Breast cancer; CAMs; DFS; E-cadherin; ER; HER-2/neu; OPN; OS; Osteopontin-c; PR; Survival; cell adhesion molecules; disease-free survival; estrogen receptor; human epidermal growth factor receptor 2; osteopontin; overall survival; pN; positive lymph node; progesterone receptor; β-Catenin