title: Modulation of 5-HT7 receptor: effect on object recognition performances in mice.
abstract: OBJECTIVE
  Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryptamine (5-CT, a 5-HT1A/1B/1D/7R agonist) and/or SB-269970 (a selective 5-HT7R antagonist) immediately after the acquisition session of the novel object recognition test.
  
  
  METHODS
  The object recognition test was performed in order to assess the effects of modulation of 5-HT7R during consolidation phase on episodic-like memory performances in mice. A protocol including 3 days of familiarisation to the apparatus has been realised in order to decrease the effect of novelty-induced arousal.
  
  
  RESULTS
  With a 2-h delay, SB-269970 (3 and 10 mg/kg, administered subcutaneously) impaired the discrimination of the novel object. With a 4-h delay, while control mice were not able to discriminate the novel object, mice treated with 5-CT (1 mg/kg) showed a significant discrimination. This promnesic effect with a long delay is effectively mediated by 5-HT7R activation since it was blocked by SB-269970 (10 mg/kg), but not by WAY-100135 (10 mg/kg) or by GR-127935 (10 mg/kg).
  
  
  CONCLUSIONS
  These data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition. Therefore, 5-HT7R could be a promising target to treat memory dysfunctions (especially episodically related deficits) related to normal or pathological ageing.
authors.affiliation: Groupe Mémoire et Plasticité Comportementale (GMPc) EA 4259, Université de Caen Basse-Normandie, Campus Horowitz, Bd Becquerel, 14032, Caen Cedex, France, thomas.freret@unicaen.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Freret
authors.forename: Eleni
authors.initials: E
authors.lastname: Paizanis
authors.forename: Gregory
authors.initials: G
authors.lastname: Beaudet
authors.forename: Andreia
authors.initials: A
authors.lastname: Gusmao-Montaigne
authors.forename: Gerald
authors.initials: G
authors.lastname: Nee
authors.forename: François
authors.initials: F
authors.lastname: Dauphin
authors.forename: Valentine
authors.initials: V
authors.lastname: Bouet
authors.forename: Michel
authors.initials: M
authors.lastname: Boulouard
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D061212:Memory, Episodic; D051379:Mice; D010069:Oxadiazoles / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000502:physiology*; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D010069:Oxadiazoles; D010636:Phenols; D010879:Piperazines; D011985:Receptors, Serotonin; C404922:SB 269970; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D013449:Sulfonamides; C104425:serotonin 7 receptor; C081293:WAY 100135; C090701:GR 127935; D012701:Serotonin; C047087:5-carboxamidotryptamine