title: Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy.
abstract: BACKGROUND
  "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA.
  
  
  OBJECTIVE
  The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls.
  
  
  METHODS
  This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20).
  
  
  CONCLUSIONS
  This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.
authors.affiliation: Department of Ophthalmology, Tel Aviv Medical Center, Israel ; sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Uri
authors.initials: U
authors.lastname: Soiberman
authors.forename: Ran
authors.initials: R
authors.lastname: Levy
authors.forename: Igal
authors.initials: I
authors.lastname: Leibovitch
keywords: ELISA; Graves’ disease; Graves’ orbitopathy