title: Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity.
abstract: During a continuing search for antimicrobial substances from Korean native wild mushroom extracts, we found that the methanolic extract of the fruiting body of Clitocybe nebularis exhibited mild antifungal activity against pathogenic fungi. Therefore we evaluated the antifungal substances and other chemical components of the fruiting body of Clitocybe nebularis, which led to the isolation of nebularine, phenylacetic acid, purine, uridine, adenine, uracil, benzoic acid, and mannitol. Nebularine showed mild antifungal activity against Magnaphorthe grisea and Trichophyton mentagrophytes, and phenylacetic acid potently inhibited the growth of Pythium ultiumand displayed moderate antifungal activity against Magnaphorthe grisea, Botrytis cinerea, and Trichophyton mentagrophytes. The other isolated compounds showed no antimicrobial activity.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-333, Korea.
authors.forename: Young-Sook
authors.initials: YS
authors.lastname: Kim
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.forename: Soon-Ja
authors.initials: SJ
authors.lastname: Seok
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
keywords: Antifungal activity; Clitocybe nebularis; Nebularine; Phenylacetic acid