title: Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.
abstract: The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Leydig cells, and each Notch component shows a specific cell-type and time-window expression pattern. This expression at key testis developmental events prompt for a role of Notch signaling in pre-pubertal spermatogonia quiescence, onset of spermatogenesis, and regulation of the spermatogenic cycle.
authors.affiliation: Reproduction and Obstetrics, CIISA, Faculty of Veterinary Medicine, Technical University of Lisbon, Lisbon, Portugal.
authors.forename: Daniel
authors.initials: D
authors.lastname: Murta
authors.forename: Marta
authors.initials: M
authors.lastname: Batista
authors.forename: Elisabete
authors.initials: E
authors.lastname: Silva
authors.forename: Alexandre
authors.initials: A
authors.lastname: Trindade
authors.forename: Domingos
authors.initials: D
authors.lastname: Henrique
authors.forename: António
authors.initials: A
authors.lastname: Duarte
authors.forename: Luís
authors.initials: L
authors.lastname: Lopes-da-Costa
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D051379:Mice; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D051880:Receptors, Notch