title: Biological activities and phytochemicals of Swietenia macrophylla King.
abstract: Swietenia macrophylla King (Meliaceae) is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the World. S. macrophylla has been widely used in folk medicine to treat various diseases. The review reveals that limonoids and its derivatives are the major constituents of S. macrophylla. There are several data in the literature indicating a great variety of pharmacological activities of S. macrophylla, which exhibits antimicrobial, anti-inflammatory, antioxidant effects, antimutagenic, anticancer, antitumor and antidiabetic activities. Various other activities like anti-nociceptive, hypolipidemic, antidiarrhoeal, anti-infective, antiviral, antimalarial, acaricidal, antifeedant and heavy metal phytoremediation activity have also been reported. In view of the immense medicinal importance of S. macrophylla, this review aimed at compiling all currently available information on its ethnomedicinal uses, phytochemistry and biological activities of S. macrophylla, showing its importance.
authors.affiliation: Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Soheil Zorofchian
authors.initials: SZ
authors.lastname: Moghadamtousi
authors.forename: Bey Hing
authors.initials: BH
authors.lastname: Goh
authors.forename: Chim Kei
authors.initials: CK
authors.lastname: Chan
authors.forename: Tara
authors.initials: T
authors.lastname: Shabab
authors.forename: Habsah Abdul
authors.initials: HA
authors.lastname: Kadir
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D008519:Medicine, Traditional; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D064209:Phytochemicals; D010936:Plant Extracts