title: Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation.
abstract: Delayed recovery of platelet count post allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been associated with worse transplant outcomes. Thrombopoietic agents have been successfully used in immune mediated thrombocytopenia or thrombocytopenia from bone marrow failure syndromes; however, the experience regarding their use after allo-HSCT is limited. Here we report on the safety and efficacy of romiplostim used in 3 consecutive patients with thrombocytopenia post allogeneic transplantation. Two patients had prolonged platelet recovery due to poor graft function while one had secondary failure of platelet recovery, likely immune mediated, post transplantation. Successful use of such agents post-transplant may improve platelet recovery, decrease rates of complications and potentially improve outcomes.
authors.affiliation: Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center Houston, Texas, USA ; Department Of Hematology-Oncology, National University Cancer Institute Singapore.
authors.forename: Limei Michelle
authors.initials: LM
authors.lastname: Poon
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Stasi
authors.forename: Uday
authors.initials: U
authors.lastname: Popat
authors.forename: Richard E
authors.initials: RE
authors.lastname: Champlin
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Ciurea
keywords: Post-transplant thrombocytopenia; allogeneic hematopoietic stem cell transplantation; romiplostim