title: The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
abstract: Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, PR China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Huang
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Zhou
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Li
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Li
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Lou
authors.forename: Dian-Ming
authors.initials: DM
authors.lastname: Li
authors.forename: Takshi
authors.initials: T
authors.lastname: Ikejima
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Shao-Jiang
authors.initials: SJ
authors.lastname: Song
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D027825:Crataegus / Q000737:chemistry* / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012639:Seeds / Q000737:chemistry / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans
keywords: 8-O-4′ Neolignans; Crataegus pinnatifida; Cytotoxicities