title: Evaluation of antifungal activity of extracts of Piper regnellii obtained by supercritical fluid extraction.
abstract: The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.
authors.affiliation: a Programa de Pós-graduação em Engenharia Química, Universidade Estadual de Maringá , Maringá , Brazil.
authors.forename: Caroline Ortega Terra
authors.initials: CO
authors.lastname: Lemos
authors.forename: Terezinha Inez Estivalet
authors.initials: TI
authors.lastname: Svidzinsk
authors.forename: Lilian Cristiane
authors.initials: LC
authors.lastname: Baeza
authors.forename: Nathielle
authors.initials: N
authors.lastname: Miranda
authors.forename: Celso Vataru
authors.initials: CV
authors.lastname: Nakamura
authors.forename: Diógenes Aparício Garcia
authors.initials: DA
authors.lastname: Cortez
authors.forename: Lúcio
authors.initials: L
authors.lastname: Cardozo-Filho
authors.forename: Vladimir Ferreira
authors.initials: VF
authors.lastname: Cabral
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; D010636:Phenols; D010936:Plant Extracts; C447284:conocarpan; C452812:eupomatenoid 6; C452811:eupomatenoid 5