title: Stability of Dobutamine Hydrochloride 4mg/mL in 5% Dextrose Injection at 5 and 23 deg C.
abstract: The stability of dobutamine hydrochloride 4 mg/mL in 5% dextrose injection has been studied using a stability-indicating, high-performance liquid chromatography assay method. The admixture injections were stable for 30 days at 5 and 23 deg C. Concentrations ranged between 98.5% and 102.6% for the room-temperature samples, and 99.6% and 101.8% for the refrigerated samples, of the initial mean concentrations. The standard curves demonstrated linearity (r2>.999). Variations within and between days were less than 3%. None of the samples appeared to form a visible precipitate or changed in color or clarity and the pH of the samples remained between 3.5 and 3.7.
authors.affiliation: Samford University, McWhorter School of Pharmacy, Birmingham, AL.
authors.forename: A A
authors.initials: AA
authors.lastname: Webster
authors.forename: B A
authors.initials: BA
authors.lastname: English
authors.forename: J M
authors.initials: JM
authors.lastname: McGuire
authors.forename: R M
authors.initials: RM
authors.lastname: Riggs
authors.forename: V
authors.initials: V
authors.lastname: Lander
authors.forename: T
authors.initials: T
authors.lastname: Buckle