title: [The plant anticoagulants with perspective to use in treatment of thrombosis].
abstract: The diseases of blood circulation system--cardiovascular diseases are the main causes of mortality in developing, low and middle-income countries all over the world. The specialists recommend the prophylaxis to avoid the dangerous complications connected with these diseases, what can reduce the final treatment costs. All over the world there is continuous research of novel, therapeutically better, more effective anticoagulant or anti-platelet agents, with multiple targets, without so many side effects. Plant material is a good source to do this kind of research. The authors show the results of their few years research on polyphenolic-polysaccharide plant conjugates, isolated from medicinal plants, popular in Poland, which is continuing in the framework of the project WROVASC--Integrated Center of Cardiovascular Medicine. This research group has been working on isolation, structure characterization and biological activity of these macromolecular compounds. Because of anticoagulant, antioxidant as well as anti-platelet properties of these plant structures they are promising to be a new source of the innovative therapeutic agent.
authors.affiliation: Wojewódzki Szpital Specjalistyczny we Wrocławiu, Ośrodek Badawczo-Rozwojowy. izabela.pawlaczyk@pwr.wroc.pl
authors.forename: Izabela
authors.initials: I
authors.lastname: Pawlaczyk
authors.forename: Marta
authors.initials: M
authors.lastname: Tsirigotis-Maniecka
authors.forename: Leszek
authors.initials: L
authors.lastname: Czerchawski
authors.forename: Witold
authors.initials: W
authors.lastname: Pilecki
authors.forename: Joanna
authors.initials: J
authors.lastname: Saluk
authors.forename: Barbara
authors.initials: B
authors.lastname: Wachowicz
authors.forename: Dorota
authors.initials: D
authors.lastname: Bonarska-Kujawa
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pyrkosz-Biardzka
authors.forename: Halina
authors.initials: H
authors.lastname: Kleszczyńska
authors.forename: Wiktor
authors.initials: W
authors.lastname: Kuliczkowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Witkiewicz
authors.forename: Roman
authors.initials: R
authors.lastname: Gancarz
mesh_terms: D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D010936:Plant Extracts