title: "Blueberry muffin" rash and large right thigh mass: a unique presentation of Langerhans cell histiocytosis.
abstract: Langerhans cell histiocytosis (LCH) is a clonal proliferation of bone marrow derived antigen-presenting cells that can involve a spectrum of cutaneous findings, with or without internal organ involvement. Neonatal LCH almost always presents with skin findings, usually petechial papules and/or erosions in a seborrheic distribution, with or without extracutaneous involvement. Previously described as varying entities, LCH is now considered a single disease process demonstrating a spectrum of clinical findings. We report a unique case of neonatal LCH presenting with a "blueberry muffin" rash in conjunction with a large soft tissue tumor.
authors.affiliation: University of New Mexico, Albuquerque, New Mexico, USA. elau@salud.unm.edu
authors.forename: Erica G
authors.initials: EG
authors.lastname: Lau
authors.forename: Shelly
authors.initials: S
authors.lastname: Stepenaskie
authors.forename: Rebecca
authors.initials: R
authors.lastname: Moran
authors.forename: Robert
authors.initials: R
authors.lastname: Quinn
authors.forename: Prasad
authors.initials: P
authors.lastname: Matthew
authors.forename: Aimee C
authors.initials: AC
authors.lastname: Smidt
mesh_terms: D001706:Biopsy; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000209:etiology* / Q000503:physiopathology; D006411:Hematopoiesis, Extramedullary; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000473:pathology* / Q000503:physiopathology; D013848:Thigh; D014747:Vinblastine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014747:Vinblastine; D011241:Prednisone