title: [How and when to evaluate hypospadias?].
abstract: Hypospadias is a frequent congenital malformation, which severity is connected to the spongiosum divergence. Biological and anatomical explorations are necessary, before the recourse to the surgeon, in posterior hypospadias, familial hypospadias, but also in any type of hypospadias associated with cryptorchidism, bifid scrotum, micropenis less than 20mm (full-term newborn), or any other anomaly (skeletal, renal, cardiac…). The "mini-puberty", occurring in the first 4-6 months of life, is a period of intense gonadotropic activity in male newborns. It allows an easy investigation of the testicular function in boys with hypospadias. Hormonal evaluation (testosterone, AMH) should be done the first day of life. Let us remind that a newborn with "hypospadias" and bilateral cryptorchidism must be considered, until proved otherwise, as a girl with congenital adrenal hyperplasia.
authors.affiliation: Endocrinologie pédiatrique, Hôpital Bicêtre, Faculté de médecine Paris 11, Centre de référence des maladies du développement sexuel, 78 rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France. Electronic address: claire.bouvattier@bct.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Bouvattier
mesh_terms: D000015:Abnormalities, Multiple / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000175:diagnosis*; D054304:Anti-Mullerian Hormone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003456:Cryptorchidism / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005832:Genital Diseases, Male / Q000175:diagnosis; D006801:Humans; D007021:Hypospadias / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000379:methods; D010413:Penis / Q000002:abnormalities; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood
chemical_list: D015415:Biomarkers; D013739:Testosterone; D054304:Anti-Mullerian Hormone