title: Damped propagation of cell polarization explains distinct PCP phenotypes of epithelial patterning.
abstract: During epithelial patterning in metazoans cells are polarized in the plane of a tissue, a process referred to as planar cell polarity (PCP). Interactions between a few molecules produce distinct phenotypes in diverse tissues in animals from flies to humans and make PCP tightly associated with tissue and organ growth control. An interesting question is whether these phenotypes share common traits. Previous computational models revealed how PCP signalling determines cell polarization in some specific contexts. We have developed a computational model, examined PCP signalling in varied molecular contexts, and revealed how details of molecular interactions and differences in molecular contexts affect the direction, speed, and propagation of cell polarization. The main finding is that damped propagation of cell polarization can generate rich variances in phenotypes of domineering non-autonomy and error correction in different contexts. These results impressively demonstrate how simple molecular interactions cause distinct, yet inherently analogous, developmental patterning.
authors.affiliation: Bioinformatics Section, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. hao.zhu@ymail.com
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
authors.forename: Markus R
authors.initials: MR
authors.lastname: Owen
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D003198:Computer Simulation; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology*; D008954:Models, Biological