title: Bone tissue formation under ideal conditions in a scaffold generated by a reaction-diffusion system.
abstract: The design of porous scaffolds for tissue engineering requires methods to generate geometries in order to control the stiffness and the permeability of the implant among others characteristics. This article studied the potential of the reaction-diffusion systems to design porous scaffolds for bone regeneration. We simulate the degradation of the scaffold material and the formation of new bone tissue over canal-like, spherical and ellipsoid structures obtained by this approach. The simulations show that the degradation and growth rates are affected by the form of porous structures. The results have indicated that the proposed method has potential as a tool to generate scaffolds with internal porosities and is comparable with other methodologies to obtain this type of structures.
authors.affiliation: Mechanical Engineering Applications and Research Group, Universidad Santo Tomás, Cra 9 No. 51-11, Bogotá, Colombia. marcovelasco@usantotomas.edu.co
authors.forename: A Marco
authors.initials: AM
authors.lastname: Velasco
authors.forename: Diego A
authors.initials: DA
authors.lastname: Garzón-Alvarado
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry*; D002113:Calcification, Physiologic / Q000502:physiology*; D003198:Computer Simulation; D004058:Diffusion; D004867:Equipment Design; D006801:Humans; D008954:Models, Biological; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes