title: IL-17 family: cytokines, receptors and signaling.
abstract: The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-17 family, the activation and regulation of IL-17 signaling as well as diseases associated with this cytokine family.
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Gu
authors.forename: Ling
authors.initials: L
authors.lastname: Wu
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology; D020381:Interleukin-17 / Q000378:metabolism*; D064307:Microbiota; D011485:Protein Binding; D053722:Receptors, Interleukin-17 / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Act1; IL-17R; Interleukin 17; Signaling transduction