title: Visual evoked potentials in neuromyelitis optica and its spectrum disorders.
abstract: Optic neuritis (ON) is a key feature of neuromyelitis optica (NMO). Recently, NMO patients of predominantly Afro-Brazilian origin were evaluated by visual evoked potentials (VEPs) and showed marked amplitude reductions. Here, we analyzed VEPs in a predominantly Caucasian cohort, consisting of 43 patients with definite NMO, 18 with anti-aquaporin (AQP) 4 antibody-seropositive NMO spectrum disorders and 61 matched healthy controls. We found reduced amplitudes in only 12.3%, prolonged latencies in 41.9% and a lack of response in 14.0% of NMO eyes. Delayed P100 latencies in eyes without prior ON suggested this was a subclinical affection. The data indicate heterogenous patterns in NMO, warranting further investigation.
authors.affiliation: Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Marius
authors.initials: M
authors.lastname: Ringelstein
authors.forename: Ingo
authors.initials: I
authors.lastname: Kleiter
authors.forename: Ilya
authors.initials: I
authors.lastname: Ayzenberg
authors.forename: Nadja
authors.initials: N
authors.lastname: Borisow
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
authors.forename: Klemens
authors.initials: K
authors.lastname: Ruprecht
authors.forename: Markus
authors.initials: M
authors.lastname: Kraemer
authors.forename: Eva
authors.initials: E
authors.lastname: Cohn
authors.forename: Brigitte
authors.initials: B
authors.lastname: Wildemann
authors.forename: Sven
authors.initials: S
authors.lastname: Jarius
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
authors.forename: Orhan
authors.initials: O
authors.lastname: Aktas
authors.forename: Philipp
authors.initials: P
authors.lastname: Albrecht
mesh_terms: D000328:Adult; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005074:Evoked Potentials, Visual; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000208:ethnology / Q000276:immunology / Q000503:physiopathology*; D011930:Reaction Time; D012189:Retrospective Studies; D013997:Time Factors; D044465:White People; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers
keywords: Aquaporin-4 antibody; P100 latency; neuromyelitis optica; neuromyelitis optica spectrum disorders; optic neuritis; visual evoked potential