title: HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.
abstract: Primary effusion lymphoma (PEL) is a non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the effect of HIV protease inhibitors, Lopinavir (LPV), Ritonavir (RTV) and Darunavir (DRV) on PEL cell lines in vitro and in vivo. LPV and RTV, but not DRV induced caspase-dependent apoptosis and suppressed NF-κB activity by inhibiting IKK phosphorylation in PEL cells. In a PEL xenograft mouse model, LPV significantly inhibited the growth and invasion of PEL cells. These results suggest that LPV may have promise for the treatment and prevention of PEL, which occurs in HIV/AIDS patients.
authors.affiliation: Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1, Honjo, Kumamoto 860-0811, Japan.
authors.forename: Ryusho
authors.initials: R
authors.lastname: Kariya
authors.forename: Manabu
authors.initials: M
authors.lastname: Taura
authors.forename: Shinya
authors.initials: S
authors.lastname: Suzu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kai
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D019288:Herpesvirus 8, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D061466:Lopinavir / Q000494:pharmacology* / Q000627:therapeutic use; D054685:Lymphoma, Primary Effusion / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D016328:NF-kappa B / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D047368:Tumor Burden / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D017320:HIV Protease Inhibitors; D016328:NF-kappa B; D061466:Lopinavir; D051057:Proto-Oncogene Proteins c-akt
keywords: HIV-1 protease inhibiton; IκB kinase; NF-κB; Primary effusion lymphoma