title: Microfluidic one-step synthesis of Fe₃O₄-chitosan composite particles and their applications.
abstract: This paper demonstrates a simple and easy approach for the one-step synthesis of Fe₃O₄-chitosan composite particles with tadpole-like shape. The length and diameter of the particles were adjustable from 638.3 μm to ca. 798 μm (length), and from 290 μm to 412 μm (diameter) by varying the flow rate of the dispersed phase. Mitoxantrone was used as the model drug in the drug release study. The encapsulation rate of the drug was 71% for chitosan particles, and 69% for magnetic iron oxide-chitosan particles, respectively. The iron oxide-chitosan composite particles had a faster release rate (up to 41.6% at the third hour) than the chitosan particles (about 24.6%). These iron oxide-chitosan composite particles are potentially useful for biomedical applications, such as magnetic responsive drug carriers, magnetic resonance imaging (MRI) enhancers, in the future.
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Taiwan.
authors.forename: Chih-Hui
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Taiwan. Electronic address: crab@isu.edu.tw.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Wang
authors.affiliation: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Taiwan.
authors.forename: Keng-Shiang
authors.initials: KS
authors.lastname: Huang
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Taiwan.
authors.forename: Chao-Pin
authors.initials: CP
authors.lastname: Kung
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Taiwan.
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Department of Biological Science and Technology, I-Shou University, Taiwan.
authors.forename: Jei-Fu
authors.initials: JF
authors.lastname: Shaw
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D044085:Microfluidics; D008942:Mitoxantrone / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D048271:Chitosan; D008942:Mitoxantrone; D052203:Ferrosoferric Oxide
keywords: Chitosan; Drug release; Iron oxide; Microfluidic droplets; One-step synthesis