title: Partial metabolic inhibition stimulates adrenal medullary secretion possibly by activating Na-dependent Ca influx mechanism.
abstract: The rabbit adrenal gland perfused throughout with a Ca-deficient, Mg-containing medium becomes responsive to a challenge with Ca (2 mM) re-introduction after treatment with cyanide, 2-deoxy-glucose plus glucose deprivation or monoiodoacetate. The results suggest that the partial metabolic inhibition leads to the reduced activity of Na pumping, thereby activating Na-dependent Ca influx mechanism.
authors.affiliation: Department of Physiology, Kagoshima University, School of Medicine, Kagoshima 890, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sorimachi
authors.forename: K
authors.initials: K
authors.lastname: Yamagami
mesh_terms: D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D002118:Calcium / Q000493:pharmacokinetics*; D003470:Culture Media / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019807:Iodoacetic Acid / Q000494:pharmacology; D007552:Isotonic Solutions / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000378:metabolism*
chemical_list: D000963:Antimetabolites; D003470:Culture Media; D003486:Cyanides; D004791:Enzyme Inhibitors; D007552:Isotonic Solutions; C010380:Locke's solution; D003847:Deoxyglucose; D012964:Sodium; D008274:Magnesium; D002118:Calcium; D019807:Iodoacetic Acid