title: Array sensing using optical methods for detection of chemical and biological hazards.
abstract: By mimicking the mammalian senses of taste and smell, artificial arrays of cross-reactive receptors have found use in a variety of sensing applications. Pattern recognition algorithms allow these arrays to be used for discriminating analytes and even for predicting the identity of unknown analytes. Furthermore, in selecting a signaling method for these assays, the choice of optical detection is particularly desirable due to its high sensitivity and the associated convenient instrumentation. This tutorial review provides a brief introduction to array sensing using optical detection and chemometrics. While differential sensing approaches have been used for a number of applications, this review focuses on progress towards the detection of chemical and biological hazards.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas, Austin, TX 78712, USA. Anslyn@austin.utexas.edu.
authors.forename: Katharine L
authors.initials: KL
authors.lastname: Diehl
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D000465:Algorithms; D001419:Bacteria / Q000302:isolation & purification; D015374:Biosensing Techniques; D002619:Chemical Warfare Agents / Q000032:analysis; D015386:Hazardous Substances / Q000032:analysis; D007220:Industrial Waste / Q000032:analysis; D046228:Microarray Analysis; D061848:Optical Imaging; D010363:Pattern Recognition, Automated; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D002619:Chemical Warfare Agents; D015386:Hazardous Substances; D007220:Industrial Waste; D055549:Volatile Organic Compounds