title: Self-referencing optofluidic ring resonator sensor for highly sensitive biomolecular detection.
abstract: The noise-suppression techniques of label-free optical ring resonator sensors are crucial to improve their practical sensing capabilities for biochemical analysis and detection in extremely small detection concentration. We have developed a self-referencing optofluidic ring resonator (SR-OFRR) to vastly improve its sensing capability as a label-free optical biosensor. By monitoring the mode-splitting separation generated on a coupled ring resonator system, the common-mode noise is suppressed by 2 orders of magnitude without any external noise-suppression techniques. In this work, we first carried out theoretical analysis to elucidate the sensing principle and then applied the SR-OFRR biosensor to experimentally detect bovine serum albumin with a concentration detection limit on the order of 1 pg/mL (~15 fM).
authors.affiliation: Key Laboratory for Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Fudan University , Shanghai 200433, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Wu
authors.forename: Liying
authors.initials: L
authors.lastname: Liu
authors.forename: Xudong
authors.initials: X
authors.lastname: Fan
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation; D002417:Cattle; D055095:Optics and Photonics / Q000295:instrumentation; D012710:Serum Albumin, Bovine / Q000032:analysis*
chemical_list: D012710:Serum Albumin, Bovine