title: PET/CT in the staging of patients with a pelvic mass suspicious for ovarian cancer.
abstract: OBJECTIVE
  To prospectively assess the value of PET/CT for staging, diagnosis and operability of ovarian cancer, with special attention to the peritoneal spread.
  
  
  METHODS
  From June 2009 to March 2011, 69 patients with suspicion of having an ovarian cancer underwent an (18)F-FDG PET/CT. To identify the diagnostic value of PET/CT, the results were compared with the findings at diagnostic laparoscopy and/or debulking surgery.
  
  
  RESULTS
  There were 56 patients with malignant tumors and 13 with benign tumors. We observed a sensitivity and specificity of 93% and 77%, respectively for malignant tumors with PET/CT. CT alone had a sensitivity and specificity of 96% and 38%, respectively. The overall FIGO classification evaluation for PET/CT and CT were the same. For the evaluation of metastases, the sensitivity of PET/CT was worse, while the specificity was better than CT. Retroperitoneal lymph node metastases were diagnosed better with PET/CT, while there was no difference for peritoneal spread and for the intestines. PET/CT detected another unknown primary tumor in 3 (4.3%) cases.
  
  
  CONCLUSIONS
  PET/CT is better than CT in detecting retroperitoneal lymph node metastases, but not for peritoneal metastases.
authors.affiliation: Division of Gynaecological Oncology, Department of Gynaecology-Obstetrics, Cancer Institute, University Hospital Leuven, Leuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Dauwen
authors.forename: B
authors.initials: B
authors.lastname: Van Calster
authors.forename: C M
authors.initials: CM
authors.lastname: Deroose
authors.forename: K
authors.initials: K
authors.lastname: Op de Beeck
authors.forename: F
authors.initials: F
authors.lastname: Amant
authors.forename: P
authors.initials: P
authors.lastname: Neven
authors.forename: P
authors.initials: P
authors.lastname: Berteloot
authors.forename: K
authors.initials: K
authors.lastname: Leunen
authors.forename: D
authors.initials: D
authors.lastname: Timmerman
authors.forename: I
authors.initials: I
authors.lastname: Vergote
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG PET/CT; Diagnosis; Operability; Ovarian cancer; Staging