title: Single-molecule studies on individual peptides and peptide assemblies on surfaces.
abstract: This review is intended to reflect the recent progress in single-molecule studies of individual peptides and peptide assemblies on surfaces. The structures and the mechanism of peptide assembly are discussed in detail. The contents include the following topics: structural analysis of single peptide molecules, adsorption and assembly of peptides on surfaces, folding structures of the amyloid peptides, interaction between amyloid peptides and dye or drug molecules, and modulation of peptide assemblies by small molecules. The explorations of peptide adsorption and assembly will benefit the understanding of the mechanisms for protein-protein interactions, protein-drug interactions and the pathogenesis of amyloidoses. The investigations on peptide assembly and its modulations could also provide a potential approach towards the treatment of the amyloidoses.
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, People's Republic of China.
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D001665:Binding Sites; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D010455:Peptides
keywords: aggregation; amyloid; peptide; scanning tunnelling microscopy; self-assembly; β-sheet