title: Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.
abstract: Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.
authors.affiliation: State Key Laboratory of Molecular and Cellular Biology, Institute of Molecular Biology and Genetics , Kyiv , Ukraine ; Department of Functional Genomics, Institute of Molecular Biology and Genetics , Kyiv , Ukraine ; Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique-Unité Propre de Recherche 3212, Université de Strasbourg , Strasbourg , France.
authors.forename: Olga
authors.initials: O
authors.lastname: Gubar
authors.forename: Dmytro
authors.initials: D
authors.lastname: Morderer
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Tsyba
authors.forename: Pauline
authors.initials: P
authors.lastname: Croisé
authors.forename: Sébastien
authors.initials: S
authors.lastname: Houy
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ory
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gasman
authors.forename: Alla
authors.initials: A
authors.lastname: Rynditch
keywords: Cdc42; endocytosis; exocytosis; intersectin; neuroendocrine cells; neurons; scaffold