title: Analgesic and anti-inflammatory activities of the methanolic stem bark extract of Nyctanthes arbor-tristis linn.
abstract: Stem bark of Nyctanthes arbor-tristis Linn. was extracted in methanol to evaluate their analgesic and anti-inflammatory activities. The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay, and tail immersion method using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration ± SEM. The anti-inflammatory activity was assessed by Carrageenan-induced rat paw oedema using diclofenac sodium as standard drug at a dose of 100 mg/kg of body weight and expressed in terms of mean increase in paw volume ± SEM. Stem bark extract was given at a dose of 250 mg/kg and 500 mg/kg of body weight. Both standard drugs and extract were administered orally to the animals. Control received distilled water orally. Results showed that Nyctanthes arbor-tristis Linn. had potent analgesic and anti-inflammatory activities.
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, Assam 786004, India. bibhuti amc@yahoo.co.in
authors.forename: Bibhuti Bhusan
authors.initials: BB
authors.lastname: Kakoti
authors.forename: Paresh
authors.initials: P
authors.lastname: Pradhan
authors.forename: Sudarshana
authors.initials: S
authors.lastname: Borah
authors.forename: Kabita
authors.initials: K
authors.lastname: Mahato
authors.forename: Mritunjay
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D007101:Immersion; D000432:Methanol / Q000737:chemistry*; D009020:Morphine / Q000494:pharmacology; D029592:Oleaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D009020:Morphine; D002351:Carrageenan; D000432:Methanol