title: Association of dopamine receptor gene polymorphism and psychological personality traits in liability for opioid addiction.
abstract: There is a clear evidence that same psychoactive substance may cause various individual physiological reactions in same environmental conditions. Although there is a general attitude on equal liability to opioid addiction, latest genetic analysis findings imply there are certain quantifiable factors that could lead to elevated individual liability towards development of opioid addiction. The goal of this study was to investigate association of certain personality traits and genetic factors (separately and in combination) with heroin addiction. Total of 200 individuals participated in the study: 100 patients on Metadone Maintenance Treatment (MMT) and 100 age and sex matched healthy volunteers. All were medically examined, interviewed and psychologically evaluated using Eysenck personality questionnaire (EPQ) and genotyped for DRD2 (rs1800497) using PCR-RFLP method. Overrepresentation of certain personality traits (neuroticism, psychoticism and extraversion/ intraversion), together with environemental risk factors such as: upbringing within incomplete families and familial history of psychotropic substances abuse, are associated with high-risk development of opioid addiction.
authors.affiliation: Public Institute for Alcoholism and Substance Abuse Sarajevo, Bolnička 25, 71000 Sarajevo, Bosnia and Herzegovina. zalcnarc@bih.net.ba
authors.forename: Nermana
authors.initials: N
authors.lastname: Mehić-Basara
authors.forename: Lilijana
authors.initials: L
authors.lastname: Oruč
authors.forename: Lejla
authors.initials: L
authors.lastname: Kapur-Pojskić
authors.forename: Jasmin
authors.initials: J
authors.lastname: Ramić
mesh_terms: D017522:Bosnia and Herzegovina; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009293:Opioid-Related Disorders / Q000235:genetics* / Q000523:psychology; D010551:Personality; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011446:Prospective Studies; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2; D003932:Heroin; D008691:Methadone