title: Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells.
abstract: Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles. It has been generally accepted for 60 years that a fixed population of primordial follicles is established in the ovaries during early life, and in most mammalian species, oocytes cannot renew themselves in postnatal or adult life. This dogma, however, has been challenged over the past decade. In this review, we summarize the recent studies on primordial follicles and putative oogonial stem cells and discuss what resources in the ovary might be more reliable and promising source tools for combating ovarian aging.
authors.affiliation: Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Deepak
authors.initials: D
authors.lastname: Adhikari
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zheng
authors.forename: Kui
authors.initials: K
authors.lastname: Liu
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D035843:Biomedical Research / Q000379:methods; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000166:cytology*; D010053:Ovary / Q000166:cytology / Q000502:physiology*; D016649:Primary Ovarian Insufficiency / Q000517:prevention & control*