title: Emerging approaches for the treatment of hypertriglyceridemia.
abstract: Hypertriglyceridemia is frequent in diabetic and obese subjects, who are at increased risk for cardiovascular diseases (CVD). Increased triglycerides (TG) are a hallmark of atherogenic dyslipidemia, representing a marker of atherogenic small dense low-density lipoproteins (sdlDL). Importantly, non-fasting/postprandial TG measurements tend to be emphasized in clinical practice for the prediction of CVD, and TG-lowering agents (primarily fibrates) have a beneficial effect on atherogenic dyslipidemia, reducing TG-rich particles and ultimately lowering the production of sdlDL. The combination of omega-3 fatty acids and statins is also recommended, and widely used in clinical practice for subjects with hypertriglyceridemia. However, a consensus on the optimal clinical use of these pharmacological agents is not fully established yet, and additional large clinical studies are needed. It seems that there is a favorable association between fish consumption and mortality from CVD, but it remains to be confirmed by future trials. Finally, there are a number of novel therapies, such as those targeting microsomal transport protein and its inhibitors, which represent new promising option for treating subjects with hypertriglyceridemia.
authors.affiliation: University of Palermo, Biomedical Department of Internal Medicine and Medical Specialties , Via del Vespro, 141, 90127, Palermo , Italy +39 091 6552945 ; +39 091 6552945 ; manfredi.rizzo@unipa.it.
authors.forename: Manfredi
authors.initials: M
authors.lastname: Rizzo
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: Dragana
authors.initials: D
authors.lastname: Nikolic
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Montalto
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D006801:Humans; D015228:Hypertriglyceridemia / Q000628:therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008019:Life Style
chemical_list: D000960:Hypolipidemic Agents