title: Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.
abstract: To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.
authors.affiliation: 1] Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University, Munich, Germany. [2] Institute for Stem Cell Research, HelmholtzZentrum, Neuherberg, Germany. [3] Department of Pharmacological Sciences, University of Milan, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Viganò
authors.forename: Wiebke
authors.initials: W
authors.lastname: Möbius
authors.forename: Magdalena
authors.initials: M
authors.lastname: Götz
authors.forename: Leda
authors.initials: L
authors.lastname: Dimou
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000166:cytology* / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D017690:Cell Transplantation / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000502:physiology; D009836:Oligodendroglia / Q000166:cytology / Q000502:physiology* / Q000637:transplantation*