title: Endovascular treatment of cerebral aneurysms using the hydrocoil embolic system.
abstract: HydroCoils are platinum helical coils coated with a layer of hydrophilic acrylic polymer (hydrogel), which on contact with blood causes disentanglement of polymer chains and expansion. We retrospectively reviewed a series of 29 patients harboring 29 cerebral aneurysms treated with the Hydrocoil Embolic System in the period 2004-2005, discussing the results of endovascular procedures in terms of safety and efficacy. The immediate post-procedure angiographic control demonstrated complete aneurysm occlusion in 21 cases (72.4%), near-complete occlusion in seven cases (24.1%), whereas in one case (3.4%) there was a procedure failure with major perfusion of the sac. Five patients (17.2%) experienced thromboembolic complications, including an asymptomatic lacunar stroke of the head of the caudate nucleus, a thalamic infarct following hypotension secondary to pulmonary edema, temporal ischemia secondary to vasospasm and a small right occipital ischemic lesion. Only one patient (3.4%) suffered a major ischemic accident. No other procedure-related complication occurred. Three-month follow-up control with MR angiography and 12-month follow-up angiography demonstrated no recurrence of aneurysms. Overall, after a mean follow-up of 12 months, the clinical outcome was good recovery in 26 patients (89.6%), moderate disability in three patients (10.3%) and no vegetative status or death. Our HydroCoil series supports the safety and midterm durability of hydrogel-coated aneurysm coils in the treatment of cerebral aneurysms.
authors.affiliation: Department of Diagnostic Imaging, University of Naples; Naples, Italy - frabriga@unina.it.
authors.forename: F
authors.initials: F
authors.lastname: Briganti
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: K
authors.initials: K
authors.lastname: Panagiotopoulos
authors.forename: M
authors.initials: M
authors.lastname: Marseglia
authors.forename: G
authors.initials: G
authors.lastname: Mariniello
authors.forename: M
authors.initials: M
authors.lastname: Napoli
authors.forename: F
authors.initials: F
authors.lastname: Caranci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000628:therapy*; D015901:Angiography, Digital Subtraction; D002544:Cerebral Infarction / Q000209:etiology; D004621:Embolization, Therapeutic / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000628:therapy*; D020766:Intracranial Embolism / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010984:Platinum; D012189:Retrospective Studies; D059409:Stroke, Lacunar / Q000209:etiology; D055815:Young Adult
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010984:Platinum