title: Green tea extract increases mRNA expression of enzymes which influence epigenetic marks in newborn female offspring from undernourished pregnant mother.
abstract: Biochemical and toxicological properties of catechin remain unclear, e.g.; how catechin affects female offspring from undernourished pregnant dams. Here, to elucidate effects of low prenatal protein on female offspring health status, changes of enzymes which modify epigenetic marks related with metabolism in kidneys from newborns were investigated after continuously administering catechin extracted from green tea to lactating maternal rats after pregnant undernourishment. We found that green tea extract intake during lactation up-regulated the activation of AMP-activated protein kinase in young female offspring from protein-restricted dams and modulated the AMP-activated protein kinase pathway in the kidney. This pathway was indicated to be stimulated by SIRT1 gene expression. The feeding of green tea extract to protein-restricted dams during lactation is likely to up-regulate AMP-activated protein kinase activation and may partly lead to alterations of the AMP-activated protein kinase pathway in female offspring kidneys. In addition, energy metabolism in fetal and offspring period with green tea extract administration might be related to enzymes which modify epigenetic marks such as DNA methyltransferase 1 and 3a.
authors.affiliation: Graduate School of Environmental Science, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Sun
authors.forename: Yuuka
authors.initials: Y
authors.lastname: Mukai
authors.forename: Masato
authors.initials: M
authors.lastname: Tanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saito
authors.forename: Shin
authors.initials: S
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurasaki
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001069:Appetite Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002392:Catechin / Q000494:pharmacology; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D044342:Malnutrition; D009035:Mothers; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D037761:Sirtuins / Q000235:genetics; D013662:Tea / Q000737:chemistry*; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D013662:Tea; D002392:Catechin; D052250:Nitric Oxide Synthase Type III; D004248:DNA (Cytosine-5-)-Methyltransferases; D055372:AMP-Activated Protein Kinases; D037761:Sirtuins