title: The stability of amphotericin B in a mixture of fungizone and optimoist.
abstract: The physical and chemical stability of amphotericin B in a mixture of Fungizone and Optimoist was studied. The mixture was prepared by mixing equal volumes of Fungizone and Optimoist. The rate of sedimentation of amphotericin B was evaluated in Fungizone, Fungizone:Optimoist (1:1) and Fungizone:distilled water (1:1) mixture. The chemical stability of amphotericin B in a mixture of Fungizone:Optimoist (1:1) was determined by high-performance liquid chromatography from samples stored at different temperatures. The rate of sedimentation was faster when Fungizone was mixed with distilled water as compared to Optimoist. Amphotericin B was stable for three weeks stored in the refrigerator (4 deg C) and for three weeks at room temperature (25 deg C). Fungizone can be diluted with Optimoist for topical application. The mixture should be shaken well before administration in order to disperse any sediment.
authors.affiliation: Department of Pharmacal Sciences, School of Pharmacy, Auburn University, AL.
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: D A
authors.initials: DA
authors.lastname: Reznik
authors.forename: R B
authors.initials: RB
authors.lastname: Gupta
authors.forename: G V
authors.initials: GV
authors.lastname: Betageri