title: Selective intermolecular amination of C-H bonds at tertiary carbon centers.
abstract: C-H insertion: A method for intermolecular amination of tertiary CH bonds is described that uses limiting amounts of substrate and a convenient phenol-derived nitrogen source. Structure-selectivity and mechanistic studies suggest that steric interaction between the substrate and active oxidant is the principal determinant of product selectivity.
authors.affiliation: Department of Chemistry, Duke University, 3236 French Science Center, 124 Science Drive, Durham, NC 27708-0346 (USA).
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Roizen
authors.forename: David N
authors.initials: DN
authors.lastname: Zalatan
authors.forename: J
authors.initials: J
authors.lastname: Du Bois
mesh_terms: D000586:Amination / Q000235:genetics*; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium
keywords: C-H insertion; amination; amines; isotope effect; rhodium