title: A facile one-pot synthesis of a fluorescent agarose-O-naphthylacetyl adduct with slow release properties.
abstract: A microwave assisted facile synthesis of a fluorescent 6-O-naphthylacetyl agarose (NA-agarose) employing carbodiimide chemistry (dicyclohexylcarbodiimide/4-dimethylaminopyridine) has been described. NA-agarose was characterized by TGA, GPC, UV spectrophotometry, fluorescence spectroscopy, FT-IR, (1)H and (13)C NMR spectra, exhibiting that in NA-agarose the naphthylacetyl group was attached to the backbone of the agarose polymer. The hydrolysis of NA-agarose in heterogeneous aqueous phase showed that the 1-naphthyl acetic acid (NAA), a plant growth regulator, got released in a controlled manner, the release rate being dependent on the hydrophilicity of the polymer adduct as well as on pH and temperature. The fluorescence emission (λmax 332 nm) of NA-agarose (1×10(-3) M) in ethylene glycol was significantly higher (ca. 82%) than that of the molar equivalent of NAA content in the product i.e. 0.08 mg in 1×10(-3) M solution. The resulting polymer would be of potential utility as a sustained release plant growth regulator and sensory applications.
authors.affiliation: Marine Biotechnology and Ecology Discipline, CSIR-Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364002, Gujarat, India.
authors.forename: Stalin
authors.initials: S
authors.lastname: Kondaveeti
authors.forename: Dharmesh R
authors.initials: DR
authors.lastname: Chejara
authors.forename: A K
authors.initials: AK
authors.lastname: Siddhanta
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives / Q000737:chemistry; D055598:Chemical Phenomena; D060326:Chemistry Techniques, Synthetic; D003692:Delayed-Action Preparations; D004024:Dicyclohexylcarbodiimide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D006868:Hydrolysis; D009280:Naphthaleneacetic Acids / Q000737:chemistry*; D012685:Sepharose / Q000737:chemistry*; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D009280:Naphthaleneacetic Acids; C034182:1-naphthaleneacetic acid; D004024:Dicyclohexylcarbodiimide; D012685:Sepharose; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine
keywords: 1-Naphthylacetic acid; Agarose; Fluorescence; Sustained release property