title: Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis.
abstract: Three novel steroids (1-3), named cattienoids A-C together with schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 μM, respectively. These compounds have neither antimicrobial activity nor inhibition of the tyrosinase.
authors.affiliation: Faculty of Chemistry, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam.
authors.forename: Bui Thi Thu
authors.initials: BTT
authors.lastname: Hien
authors.affiliation: Faculty of Biology, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam.
authors.forename: Le Thi Phuong
authors.initials: LTP
authors.lastname: Hoa
authors.affiliation: Department of Science & Technology, Lam dong, Viet Nam.
authors.forename: Le Xuan
authors.initials: LX
authors.lastname: Tham
authors.affiliation: Faculty of Chemistry, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam. Electronic address: quangdn@hnue.edu.vn.
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D048690:Fruiting Bodies, Fungal; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D020072:Polyporales / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D013256:Steroids; C000588646:cattienoid B; C000588645:schisanlactone A
keywords: Anticancer; Steroid; Tomophagus cattienensis; Tyrosinase