title: The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.
abstract: Polyphenols are representative bioactive substances with diverse biological effects. Here, we show that apigenin, a flavonoid, has suppressive effects on microRNA (miRNA) function. The effects were mediated by impaired maturation of a subset of miRNAs, probably through inhibition of the phosphorylation of TRBP, a component of miRNA-generating complexes via impaired mitogen-activated protein kinase (MAPK) Erk activation. While glucose intolerance was observed in miRNA103 (miR103)-overexpressing transgenic mice, administration of apigenin improved this pathogenic status likely through suppression of matured miR103 expression levels. These results suggest that apigenin may have favorable effects on the pathogenic status induced by overexpression of miRNA103, whose maturation is mediated by phosphorylated TRBP.
authors.affiliation: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. otsukamo-tky@umin.ac.jp
authors.forename: Motoko
authors.initials: M
authors.lastname: Ohno
authors.forename: Chikako
authors.initials: C
authors.lastname: Shibata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kishikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Akemi
authors.initials: A
authors.lastname: Takata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kojima
authors.forename: Masao
authors.initials: M
authors.lastname: Akanuma
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kang
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Otsuka
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
mesh_terms: D000818:Animals; D047310:Apigenin / Q000008:administration & dosage*; D002110:Caffeine / Q000008:administration & dosage*; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects
chemical_list: C544749:MIRN103 microRNA, human; D035683:MicroRNAs; D002110:Caffeine; D047310:Apigenin; D005947:Glucose