title: Nocellaralactone, a new monoterpenoid with anti-inflammatory activity, from Olea europaea L., cultivar Nocellara del Belice.
abstract: Nocellara del Belice, a cultivated variety (cultivar) of olive tree (Olea europæa L.), was examined with respect to the medium-polar compounds present in the wastewaters of olive oil extraction at the end of 2007. Charcoal-polyamide chromatography of obtained wastewaters showed the presence of the chemotaxonomical markers of Olea europaea. In addition a new compound was isolated which resulted to be a lactone related to oleuropein aglycone. We propose the name of nocellaralactone (NOC). This compound is also present in the leaves and it appears to be structurally, probably biogenetically, related to jasminanhydride, a monoterpenoid previously isolated from Jasminum grandiflorum. NOC showed a significant in vitro anti-inflammatory activity.
authors.affiliation: a Dipartimento di Chimica , Sapienza Università di Roma , Piazzale Aldo Moro 5, 00185 , Roma , Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Serrilli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Frasca
authors.forename: Luisa
authors.initials: L
authors.lastname: Rizza
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Bonina
authors.forename: Armandodoriano
authors.initials: A
authors.lastname: Bianco
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D039821:Monoterpenes / Q000737:chemistry* / Q000494:pharmacology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D031658:Olea / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; C573420:ICAM1 protein, human; D039821:Monoterpenes; D010936:Plant Extracts; D018799:Intercellular Adhesion Molecule-1; D052247:Nitric Oxide Synthase Type II