title: Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson's disease.
abstract: There is a substantial amount of evidence from experimental parkinsonian models to show the neuroprotective effects of monoamine oxidase-B (MAOB) inhibitors. They have been studied for their potential disease-modifying effects in Parkinson's disease (PD) for over 20 years in various clinical trials. This review provides a summary of the clinical trials and discusses the implications of their results in the context of disease-modification in PD. Earlier clinical trials on selegiline were confounded by symptomatic effects of this drug. Later clinical trials on rasagiline using delayed-start design provide newer insights in disease-modification in PD but success in achieving the aims of this strategy remain elusive due to obstacles, some of which may be insurmountable.
authors.affiliation: Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong, China. slho@hku.hk.
authors.forename: Kay Cheong
authors.initials: KC
authors.lastname: Teo
authors.forename: Shu-Leong
authors.initials: SL
authors.lastname: Ho