title: Differentiation of lymphoma versus sarcoidosis in the setting of mediastinal-hilar lymphadenopathy: assessment with diffusion-weighted MR imaging.
abstract: OBJECTIVE
  To determine the performance of diffusion-weighted magnetic resonance imaging in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy.
  
  
  METHODS
  Forty-four mediastinal-hilar lymphadenopathy were examined in 27 patients with T1- and T2-weighted conventional images. Then, two diffusion-weighted images were obtained with b = 0 and 1000 s/mm2 values and apparent diffusion coefficients (ADCs) were calculated. The statistical significance of differences between measurements was tested using the Student-t test.
  
  
  RESULTS
  The ADC value in the lymphoma group was lower than in the sarcoidosis group, and the difference was statistically significant (p < 0.001). By using the cut-off value of 1.266 x 10(-3) mm2/s, ADC had a sensitivity of 100%, specificity of 81%, positive predictive value of 100%, and negative predictive value of 77% for the differentiation of lymphoma and sarcoidosis. With the cut-off value of 1,97 x 10(-3) mm2/s, ADC had a sensitivity of 50%, specificity of 99.4%, positive predictive value of 68%, and negative predictive value of 91%.
  
  
  CONCLUSIONS
  Diffusion-weighted imaging may be useful besides other modalities in differentiating lymphoma from sarcoidosis in mediastinal-hilar lymphadenopathy.
authors.affiliation: Department of Radiology, School of Medicine, University of Kocaeli, Turkey. svtgumustas@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Gümüştaş
authors.forename: N
authors.initials: N
authors.lastname: Inan
authors.forename: Gür
authors.initials: G
authors.lastname: Akansel
authors.forename: I
authors.initials: I
authors.lastname: Başyïğït
authors.forename: E
authors.initials: E
authors.lastname: Cïftçi
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000209:etiology; D008223:Lymphoma / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D012372:ROC Curve; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D055815:Young Adult