title: The NF-κB signalling pathway in osteoarthritis.
abstract: Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and extracellular matrix (ECM) degradation products. Upon stimulation, the activated NF-κB molecules trigger the expression of an array of genes which induce destruction of the articular joint, leading to osteoarthritis (OA) onset and progression. Therefore, targeted strategies that interfere with NF-κB signalling could offer novel potential therapeutic options for OA treatment. In this review, we discuss the involvement of NF-κB in OA pathogenesis and how pharmacological inhibition of the NF-κB signalling pathway affects OA incidence and evolution.
authors.affiliation: Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Rigoglou
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B
keywords: Cartilage destruction; Chondrocytes; NF-κB; Osteoarthritis; Signal transduction