title: Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects.
abstract: OBJECTIVE
  A combination of bioactive food ingredients (capsaicinoids, epigallocatechin gallate, piperin, and l-carnitine, CBFI) may promote satiety and thermogenesis. The study was conducted in order to assess whether there is any effect on satiety, resting energy expenditure (REE), respiratory quotient, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and glycerol release, following a standardized mixed meal with or without single consumption of a CBFI.
  
  
  METHODS
  An 8-week randomized double-blind placebo-controlled trial.
  
  
  METHODS
  Dietetic and Metabolic Unit, Azienda di Servizi alla Persona, University of Pavia and "Villa delle Querce" Clinical Rehabilitation Institute, Rome, Italy.
  
  
  METHODS
  Thirty-seven overweight adults (body mass index [BMI]: 25-35).
  
  
  METHODS
  Nineteen overweight subjects were included in the supplemented group (14 women, 5 men; age 46.4 ± 6.4; BMI: 30.5 ± 3.3) and 18 in the placebo group (13 women, 5 men; age 40.8 ± 11.5; BMI: 30.1 ± 2.6). Satiety was assessed using 100-mm visual analogue scales (VAS) and the area under the curve was calculated.
  
  
  RESULTS
  All measured parameters increased significantly in comparison with baseline in response to meal, both with CBFI and with placebo. However, throughout the study day, the supplemented group experienced a significantly greater increase than the placebo group in their sensation of satiety following acute administration of the supplement.
  
  
  CONCLUSIONS
  CBFI may therefore be of great value in the treatment of overweight patients by increasing satiety and stimulating thermogenesis.
authors.affiliation: Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, Endocrinology and Nutrition Unit, University of Pavia, Pavia, Italy. mariangela.rondanelli@unipv.it
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.forename: Annalisa
authors.initials: A
authors.lastname: Opizzi
authors.forename: Simone
authors.initials: S
authors.lastname: Perna
authors.forename: Milena
authors.initials: M
authors.lastname: Faliva
authors.forename: Sebastiano Bruno
authors.initials: SB
authors.lastname: Solerte
authors.forename: Marisa
authors.initials: M
authors.lastname: Fioravanti
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: Cava
authors.initials: C
authors.lastname: Edda
authors.forename: Paolini
authors.initials: P
authors.lastname: Maddalena
authors.forename: Scavone
authors.initials: S
authors.lastname: Luciano
authors.forename: Ceccarelli
authors.initials: C
authors.lastname: Paola
authors.forename: Castellaneta
authors.initials: C
authors.lastname: Emanuela
authors.forename: Savina
authors.initials: S
authors.lastname: Claudia
authors.forename: Lorenzo Maria
authors.initials: LM
authors.lastname: Donini
mesh_terms: D000328:Adult; D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use; D019540:Area Under Curve; D001481:Basal Metabolism / Q000187:drug effects*; D052117:Benzodioxoles / Q000494:pharmacology / Q000627:therapeutic use; D002211:Capsaicin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D002331:Carnitine / Q000494:pharmacology / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D019587:Dietary Supplements; D004311:Double-Blind Method; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides / Q000494:pharmacology / Q000627:therapeutic use; D012527:Satiation / Q000187:drug effects*; D012528:Satiety Response
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D005230:Fatty Acids, Nonesterified; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; D052216:Glucagon-Like Peptide 1; D002392:Catechin; C045651:epigallocatechin gallate; D005990:Glycerol; D002211:Capsaicin; D002331:Carnitine; C008922:piperine