title: Transgenic Rat Models of Huntington's Disease.
abstract: Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.
authors.affiliation: Departments of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: João Casaca
authors.initials: JC
authors.lastname: Carreira
authors.forename: Ali
authors.initials: A
authors.lastname: Jahanshahi
authors.forename: Dagmar
authors.initials: D
authors.lastname: Zeef
authors.forename: Ersoy
authors.initials: E
authors.lastname: Kocabicak
authors.forename: Rinske
authors.initials: R
authors.lastname: Vlamings
authors.forename: Stephan
authors.initials: S
authors.lastname: von Hörsten
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006816:Huntington Disease / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D055647:Rats, Transgenic