title: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation.
abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of non-Hodgkin lymphoma, in which lymphoma cells infiltrate preferentially into subcutaneous adipose tissue. Although various treatment trials for SPTCL have been attempted, no standardized therapy has been established. Here, we report a case of α/β(+) T-cell-phenotype SPTCL (SPTCL-AB) with hemophagocytosis (HPS) in a 14-year-old girl, who presented with low-grade fever, general fatigue and chest swelling. Laboratory examinations revealed leukocytopenia, and bone marrow aspiration cytology showed HPS. The diagnosis of SPTCL-AB was made by biopsy on the basis of thickened subcutaneous tissue in the chest wall. Following high-dose chemotherapy (HDT) of BFM-NHL & ALL-90, autologous peripheral blood stem cell transplantation (auto-PBSCT) was performed. The patient responded to the treatment and has remained asymptomatic for 2 years. Our results suggest that a combination of HDT of BFM-NHL & ALL-90 and auto-SCT treatment is effective for SPTCL associated with HPS.
authors.affiliation: Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan. sakkuei@iwate-med.ac.jp
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sakurai
authors.forename: Takashi
authors.initials: T
authors.lastname: Satoh
authors.forename: Yashima-Abo
authors.initials: YA
authors.lastname: Akiko
authors.forename: Chihaya
authors.initials: C
authors.lastname: Maesawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Mikiya
authors.initials: M
authors.lastname: Endo
authors.forename: Toshihide
authors.initials: T
authors.lastname: Akasaka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Masuda
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D057899:Cytophagocytosis / Q000276:immunology*; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D015434:Panniculitis / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D012867:Skin / Q000473:pathology; D014182:Transplantation, Autologous