title: [Solitary spinal metastases. Is aggressive surgical management justified?].
abstract: Advances in oncological and surgical therapies have led to a significant increase in life expectancy of cancer patients and also prolonged survival of patients with isolated or multiple metastases. Among the skeletal manifestations the spine is the most often affected site. Using novel imaging techniques with higher resolution and use of metabolic signatures, the screening of cancer patients has improved considerably. Consequently, the diagnosis of metastases is becoming increasingly more sensitive. Therefore, but also due to more effective polychemotherapy protocols, singular or solitary metastases are more frequently observed either in the early stages or as a result of a controlled malignant tumor entity (stable disease). The questions whether a solitary metastasis really exists (illusion or reality?) and its radical oncological and surgical treatment as a circumscribed singular tumor manifestation, is really relevant for the overall prognosis, remains controversial. However, it seems evident that a biologically favorable underlying tumor biology, radical treatment of the primary tumor and a long metastasis-free interval are valid predictors of a good oncological outcome. In the presence of a solitary metastasis under these circumstances (typical example: solitary metastasis of renal cell carcinoma many years after radical tumor nephrectomy) a radical surgical procedure (en bloc spondylectomy) can significantly improve the long-term prognosis of this patient group in combination with adjuvant chemotherapy and/or radiotherapy. However, a thorough evaluation of the overall survival prognosis, a detailed and complete staging followed by a treatment consensus in the interdisciplinary tumor board has to precede any therapeutical decisions.
authors.affiliation: Centrum für Muskuloskeletale Chirurgie, Klinik für Orthopädie, Klinik für Unfall- und Wiederherstellungschirurgie, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Druschel
authors.forename: A C
authors.initials: AC
authors.lastname: Disch
authors.forename: M
authors.initials: M
authors.lastname: Pumberger
authors.forename: P
authors.initials: P
authors.lastname: Schwabe
authors.forename: I
authors.initials: I
authors.lastname: Melcher
authors.forename: N P
authors.initials: NP
authors.lastname: Haas
authors.forename: K-D
authors.initials: KD
authors.lastname: Schaser
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003657:Decision Making; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007796:Laminectomy / Q000379:methods*; D018579:Patient Selection; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents