title: The Mayo Clinic Biobank: a building block for individualized medicine.
abstract: OBJECTIVE
  To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank.
  
  
  METHODS
  Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions.
  
  
  RESULTS
  After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use.
  
  
  CONCLUSIONS
  The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. olsonj@mayo.edu
authors.forename: Janet E
authors.initials: JE
authors.lastname: Olson
authors.forename: Euijung
authors.initials: E
authors.lastname: Ryu
authors.forename: Kiley J
authors.initials: KJ
authors.lastname: Johnson
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Koenig
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Maschke
authors.forename: Jody A
authors.initials: JA
authors.lastname: Morrisette
authors.forename: Mark
authors.initials: M
authors.lastname: Liebow
authors.forename: Paul Y
authors.initials: PY
authors.lastname: Takahashi
authors.forename: Zachary S
authors.initials: ZS
authors.lastname: Fredericksen
authors.forename: Ruchi G
authors.initials: RG
authors.lastname: Sharma
authors.forename: Kari S
authors.initials: KS
authors.lastname: Anderson
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Hathcock
authors.forename: Jason A
authors.initials: JA
authors.lastname: Carnahan
authors.forename: Jyotishman
authors.initials: J
authors.lastname: Pathak
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Beebe
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
mesh_terms: D000293:Adolescent; D000328:Adult; D026683:Advisory Committees; D000368:Aged; D001800:Blood Specimen Collection; D016208:Databases, Factual; D057286:Electronic Health Records; D005260:Female; D006801:Humans; D007258:Informed Consent; D008297:Male; D008487:Medical History Taking; D008498:Medical Record Linkage; D008875:Middle Aged; D008910:Minnesota; D018579:Patient Selection; D057285:Precision Medicine / Q000379:methods* / Q000706:statistics & numerical data; D055815:Young Adult
keywords: BMI; BRFSS; Behavioral Risk Factor Surveillance System Survey; CAB; Community Advisory Board; DCE; Deliberative Community Engagement; EMR; WBC; body mass index; electronic medical record; white blood cell