title: Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation.
abstract: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and mortality. However, the underlying mechanism is unclear. In this cross-sectional study, we investigated the influence of OSA on metabolic syndrome (MetS) and inflammation, which were considered as cardiovascular risks. A total of 144 consecutive male patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for glucose, high-sensitivity C-reactive protein (hs-CRP) and lipids measurement. A metabolic score was established as the total number of the positive diagnostic criteria of metabolic syndrome for each patient. Systolic blood pressure, diastolic blood pressure, fasting glucose, hs-CRP and metabolic score significantly increased with the aggravation of OSA severity. Metabolic score increased from 1.74 ± 1.20 to 2.89 ± 0.99 with OSA severity (p = 0.000). hs-CRP increased from 0.68 (0.43-1.10) to 1.44 (0.62-4.02) mg/L with OSA severity (p = 0.002). After adjustment for confounders, apnea-hypopnea index and body mass index (BMI) were the major contributing factors for metabolic score (β = 0.257, p = 0.003 and β = 0.344, p = 0.000, respectively), lowest O2 saturation and BMI were the independent predictors of hs-CRP (β = -0.255, p = 0.003 and β = 0.295, p = 0.001, respectively). OSA is independently associated with sum of metabolic components and hs-CRP.
authors.affiliation: Fujian Provincial Sleep-Disordered Breathing Clinic Center, Fuzhou, Fujian Province, People's Republic of China, chang4e@126.com.
authors.forename: Qi-Chang
authors.initials: QC
authors.lastname: Lin
authors.forename: Li-Da
authors.initials: LD
authors.lastname: Chen
authors.forename: Yao-Hua
authors.initials: YH
authors.lastname: Yu
authors.forename: Kai-Xiong
authors.initials: KX
authors.lastname: Liu
authors.forename: Shao-Yong
authors.initials: SY
authors.lastname: Gao
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism*; D006949:Hyperlipidemias / Q000150:complications / Q000378:metabolism*; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D056128:Obesity, Abdominal / Q000150:complications / Q000378:metabolism; D017286:Polysomnography; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein