title: Evaluation of glycated albumin and microalbuminuria as early risk markers of nephropathy in type 2 diabetes mellitus.
abstract: BACKGROUND
  Since Glycated Albumin (GA) reflects short term variations and glycated protein shows degrees of hyperglycaemia, the objective of this study was to find GA and microalbuminuria as a early risk markers along with the duration of Uncontrolled Diabetes Mellitus in type 2 diabetic nephropathy.
  
  
  METHODS
  The present cross-sectional study included randomly selected Uncontrolled Type 2DM (n = 75), controlled Type 2DM (n = 75) and healthy controls (n = 75). Their fasting venous blood samples were obtained for GA and serum creatinine, while their morning urine samples were obtained for detection of microalbuminuria. Statistical analysis was done by using SPSS, version 16.0. One-Way ANOVA was performed. All p-values which were ≤ 0.05 were considered as statistically significant.
  
  
  RESULTS
  The mean GA, microalbuminuria and serum creatinine were the highest in Uncontrolled DM as compared to those in Controlled DM respectively. Microalbuminuria and GA had a significant correlation with the duration of diabetes (p<0.0001).
  
  
  CONCLUSIONS
  The present study identified that the risk of microalbuminuria increased with a poor glycaemic control. A persistent increase in GA and microalbuminuria may be considered as risk markers in diabetic nephropathy. Therefore, a regular screening for microalbuminuria and estimation of GA can help in the clinical management, to prevent complications.
authors.affiliation: Lecturer, Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Science & Research , Melmaruvathur, Tamil Nadu, India .
authors.forename: Suresh Babu
authors.initials: SB
authors.lastname: Kondaveeti
authors.forename: Kumaraswamy
authors.initials: K
authors.lastname: D
authors.forename: Shishir
authors.initials: S
authors.lastname: Mishra
authors.forename: Aravind
authors.initials: A
authors.lastname: Kumar R
authors.forename: I Anand
authors.initials: IA
authors.lastname: Shaker
keywords: Diabetic nephropathy; Glycated albumin; Microalbuminuria