title: Clinical significance and prognostic value of pentraxin-3 as serologic biomarker for lung cancer.
abstract: OBJECTIVE
  Lung cancer is prevalent worldwide and improvements in timely and effective diagnosis are need. Pentraxin-3 as a novel serum marker for lung cancer (LC) has not been validated in large cohort studies. The aim of the study was to assess its clinical value in diagnosis and prognosis.
  
  
  METHODS
  We analyzed serum PTX-3 levels in a total of 1,605 patients with LC, benign lung diseases and healthy controls, as well as 493 non- lung cancer patients including 12 different types of cancers. Preoperative and postoperative data were further assessed in patients undergoing LC resection. The diagnostic performance of PTX-3 for LC and early-stage LC was assessed using receiver operating characteristics (ROC) by comparing with serum carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA 21-1).
  
  
  RESULTS
  Levels of PTX-3 in serum were significantly higher in patients with LC than all controls. ROC curves showed the optimum diagnostic cutoff was 8.03ng/mL (AUC 0.823, [95%CI 0.789-0.856], sensitivity 72.8%, and specificity 77.3% in the test cohort; 0.802, [95%CI 0.762-0.843], sensitivity 69.7%, and specificity 76.4% in the validate cohort). Similar diagnostic performance of PTX-3 was observed for early-stage LC. PTX-3 decreased following surgical resection of LC and increased with tumor recurrence. Significantly elevated PTX-3 levels were also seen in patients with non-lung cancers.
  
  
  CONCLUSIONS
  The present data revealed that PTX-3 was significantly increased in both tissue and serum samples in LC patients. PTX-3 is a valuable biomarker for LC and improved identification of patients with LC and early-stage LC from those with non-malignant lung diseases.
authors.affiliation: Department of Clinical Laboratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China. ren_weihong@hotmail.com
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Ren
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.forename: Nian-Yue
authors.initials: NY
authors.lastname: Wang
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology; D000951:Antigens, Neoplasm / Q000097:blood; D015415:Biomarkers / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053539:Keratin-19 / Q000097:blood; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D011230:Precancerous Conditions / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D000951:Antigens, Neoplasm; D015415:Biomarkers; D014408:Biomarkers, Tumor; D002097:C-Reactive Protein; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C102012:antigen CYFRA21.1