title: Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010.
abstract: BACKGROUND
  We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the burden of disease attributable to mental and substance use disorders in terms of disability-adjusted life years (DALYs), years of life lost to premature mortality (YLLs), and years lived with disability (YLDs).
  
  
  METHODS
  For each of the 20 mental and substance use disorders included in GBD 2010, we systematically reviewed epidemiological data and used a Bayesian meta-regression tool, DisMod-MR, to model prevalence by age, sex, country, region, and year. We obtained disability weights from representative community surveys and an internet-based survey to calculate YLDs. We calculated premature mortality as YLLs from cause of death estimates for 1980-2010 for 20 age groups, both sexes, and 187 countries. We derived DALYs from the sum of YLDs and YLLs. We adjusted burden estimates for comorbidity and present them with 95% uncertainty intervals.
  
  
  RESULTS
  In 2010, mental and substance use disorders accounted for 183·9 million DALYs (95% UI 153·5 million-216·7 million), or 7·4% (6·2-8·6) of all DALYs worldwide. Such disorders accounted for 8·6 million YLLs (6·5 million-12·1 million; 0·5% [0·4-0·7] of all YLLs) and 175·3 million YLDs (144·5 million-207·8 million; 22·9% [18·6-27·2] of all YLDs). Mental and substance use disorders were the leading cause of YLDs worldwide. Depressive disorders accounted for 40·5% (31·7-49·2) of DALYs caused by mental and substance use disorders, with anxiety disorders accounting for 14·6% (11·2-18·4), illicit drug use disorders for 10·9% (8·9-13·2), alcohol use disorders for 9·6% (7·7-11·8), schizophrenia for 7·4% (5·0-9·8), bipolar disorder for 7·0% (4·4-10·3), pervasive developmental disorders for 4·2% (3·2-5·3), childhood behavioural disorders for 3·4% (2·2-4·7), and eating disorders for 1·2% (0·9-1·5). DALYs varied by age and sex, with the highest proportion of total DALYs occurring in people aged 10-29 years. The burden of mental and substance use disorders increased by 37·6% between 1990 and 2010, which for most disorders was driven by population growth and ageing.
  
  
  CONCLUSIONS
  Despite the apparently small contribution of YLLs--with deaths in people with mental disorders coded to the physical cause of death and suicide coded to the category of injuries under self-harm--our findings show the striking and growing challenge that these disorders pose for health systems in developed and developing regions. In view of the magnitude of their contribution, improvement in population health is only possible if countries make the prevention and treatment of mental and substance use disorders a public health priority.
  
  
  BACKGROUND
  Queensland Department of Health, National Health and Medical Research Council of Australia, National Drug and Alcohol Research Centre-University of New South Wales, Bill & Melinda Gates Foundation, University of Toronto, Technische Universität, Ontario Ministry of Health and Long Term Care, and the US National Institute of Alcohol Abuse and Alcoholism.
authors.affiliation: School of Population Health, University of Queensland, Herston, QLD, Australia; Queensland Centre for Mental Health Research, Wacol, QLD, Australia. Electronic address: h.whiteford@uq.edu.au.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Whiteford
authors.forename: Louisa
authors.initials: L
authors.lastname: Degenhardt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rehm
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Baxter
authors.forename: Alize J
authors.initials: AJ
authors.lastname: Ferrari
authors.forename: Holly E
authors.initials: HE
authors.lastname: Erskine
authors.forename: Fiona J
authors.initials: FJ
authors.lastname: Charlson
authors.forename: Rosana E
authors.initials: RE
authors.lastname: Norman
authors.forename: Abraham D
authors.initials: AD
authors.lastname: Flaxman
authors.forename: Nicole
authors.initials: N
authors.lastname: Johns
authors.forename: Roy
authors.initials: R
authors.lastname: Burstein
authors.forename: Christopher J L
authors.initials: CJ
authors.lastname: Murray
authors.forename: Theo
authors.initials: T
authors.lastname: Vos
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D006233:Persons with Disabilities / Q000706:statistics & numerical data; D005260:Female; D014943:Global Health; D006801:Humans; D007223:Infant; D008017:Life Expectancy; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology*; D008875:Middle Aged; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*; D055815:Young Adult