title: Neuraminidase inhibitors for influenza B virus infection: efficacy and resistance.
abstract: Many aspects of the biology and epidemiology of influenza B viruses are far less studied than for influenza A viruses, and one of these aspects is efficacy and resistance to the clinically available antiviral drugs, the neuraminidase (NA) inhibitors (NAIs). Acute respiratory infections are one of the leading causes of death in children and adults, and influenza is among the few respiratory infections that can be prevented and treated by vaccination and antiviral treatment. Recent data has suggested that influenza B virus infections are of specific concern to pediatric patients because of the increased risk of severe disease. Treatment of influenza B is a challenging task for the following reasons: This review presents current knowledge of the efficacy of NAIs for influenza B virus and antiviral resistance in clinical, surveillance, and experimental studies.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Burnham
authors.forename: Tatiana
authors.initials: T
authors.lastname: Baranovich
authors.forename: Elena A
authors.initials: EA
authors.lastname: Govorkova
mesh_terms: D000146:Acids, Carbocyclic; D000998:Antiviral Agents / Q000494:pharmacology*; D003517:Cyclopentanes / Q000494:pharmacology; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D009981:Influenza B virus / Q000187:drug effects* / Q000201:enzymology*; D007251:Influenza, Human / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors*; D053243:Zanamivir / Q000494:pharmacology
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D006146:Guanidines; D014764:Viral Proteins; D053139:Oseltamivir; C541223:NA protein, influenza B virus; D009439:Neuraminidase; D053243:Zanamivir; C414210:peramivir
keywords: Antiviral drug resistance; Influenza B virus; Neuraminidase inhibitors; Oseltamivir; Peramivir; Zanamivir