title: Development of adult T-cell leukemia in a patient with rheumatoid arthritis treated with tocilizumab.
abstract: Tocilizumab (TCZ) was administered from 2004 to 2008 in a 52-year-old woman with rheumatoid arthritis (RA) refractory to methotrexate (MTX) as a clinical trial. TCZ therapy with MTX was resumed in March 2009 due to exacerbation of RA. The patient was an human T-lymphotropic virus type I (HTLV-I) carrier, and, in April 2011, a peripheral blood smear showed many atypical lymphocytes, thus leading to a diagnosis of adult T-cell leukemia (ATL). Complete remission of ATL was achieved with a standard therapeutic regimen.
authors.affiliation: Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. nhideki@nagasaki-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ueki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Saito
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tomoki
authors.initials: T
authors.lastname: Naoe
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000139:chemically induced* / Q000175:diagnosis*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab