title: Synthesis and spectral characterization of Schiff base complexes of Cu(II), Co(II), Zn(II) and VO(IV) containing 4-(4-aminophenyl)morpholine derivatives: antimicrobial evaluation and anticancer studies.
abstract: Metal(II) chelates of Schiff bases derived from the condensation of 4-morpholinoaniline with substituted salicylaldehyde have been prepared and characterized by (1)H NMR, IR, electronic, EPR, and magnetic measurement studies. The complexes are of the type M(X-MPMP)2 [where M=Cu(II), Co(II)), Zn(II), or VO(IV); MPMP=2-[(4 morpholinophenyl imino) methyl] 4-X-phenol, X=Cl, (L1H), X=Br (L2H)]. Single crystal X-ray crystallography studies confirm the structure of newly synthesized Schiff bases. The Schiff bases act as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The free ligands and metal complexes are screened for their biopotency. Metal complexes exhibit better activity than ligands. Anticancer activity of ligands and their metal complexes are evaluated in human heptocarcinoma(HepG2) cells. The preliminary bioassay indicates that the Schiff base and its zinc complex exhibit inhibitory activity against the human gastric cancer cell lines.
authors.affiliation: Department of Chemistry, Government Arts College, Melur, Madurai 625 106, India.
authors.forename: K
authors.initials: K
authors.lastname: Dhahagani
authors.forename: S
authors.initials: S
authors.lastname: Mathan Kumar
authors.forename: G
authors.initials: G
authors.lastname: Chakkaravarthi
authors.forename: K
authors.initials: K
authors.lastname: Anitha
authors.forename: J
authors.initials: J
authors.lastname: Rajesh
authors.forename: A
authors.initials: A
authors.lastname: Ramu
authors.forename: G
authors.initials: G
authors.lastname: Rajagopal
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D003460:Crystallization; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014638:Vanadates / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009942:Organometallic Compounds; D012545:Schiff Bases; D003035:Cobalt; D014638:Vanadates; D003300:Copper; D015032:Zinc
keywords: Anticancer; Antimicrobial; Crystal studies; HepG2 cells; Morpholinoaniline; Schiff bases