title: Copper-catalyzed domino cycloaddition/C-N coupling/cyclization/(C-H arylation): an efficient three-component synthesis of nitrogen polyheterocycles.
abstract: A cat of all trades: A single copper catalyst promoted up to three reaction steps with separate catalytic cycles in a domino sequence (azide-alkyne cycloaddition/Goldberg amidation/Camps cyclization/(CH arylation)) for the rapid construction of complex heterocycles from three simple components under mild conditions. Facile cleavage of the triazole ring enables further elaboration of the condensation products.
authors.affiliation: Department of Medicinal Chemistry, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (USA). wqian@amgen.com.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Qian
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Allen
mesh_terms: D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D061565:Cycloaddition Reaction / Q000379:methods*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D003300:Copper; D009584:Nitrogen
keywords: CH arylation; amidation; copper catalysis; heterocycles; multicomponent reactions