title: Receptor recognition and cross-species infections of SARS coronavirus.
abstract: Receptor recognition is a major determinant of the host range, cross-species infections, and pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV). A defined receptor-binding domain (RBD) in the SARS-CoV spike protein specifically recognizes its host receptor, angiotensin-converting enzyme 2 (ACE2). This article reviews the latest knowledge about how RBDs from different SARS-CoV strains interact with ACE2 from several animal species. Detailed research on these RBD/ACE2 interactions has established important principles on host receptor adaptations, cross-species infections, and future evolution of SARS-CoV. These principles may apply to other emerging animal viruses, including the recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV). This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10years of research on highly pathogenic human coronaviruses".
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Electronic address: lifang@umn.edu.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D003428:Cross Infection / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D045169:Severe Acute Respiratory Syndrome / Q000378:metabolism / Q000821:virology*; D013045:Species Specificity; D064370:Spike Glycoprotein, Coronavirus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D011991:Receptors, Virus; D064370:Spike Glycoprotein, Coronavirus; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2
keywords: Coronavirus; Middle East respiratory syndrome; Severe acute respiratory syndrome; Spike protein; Virus evolution