title: Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis.
abstract: Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans.
authors.affiliation: Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Izawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D005810:Multigene Family; D010456:Peptides, Cyclic / Q000096:biosynthesis*; D017422:Sequence Analysis, DNA; D048170:Streptomyces lividans / Q000235:genetics* / Q000378:metabolism; D013854:Thioamides
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010456:Peptides, Cyclic; D013854:Thioamides; C509635:thioviridamide