title: Gonadotropin inhibitory hormone (GnIH) as a regulator of gonadotropes.
abstract: Gonadotropin inhibitory hormone (GnIH) has emerged as a negative regulator of gonadotrope function in a range of species. In rodents, such as rats and mice, GnIH exerts influence upon GnRH cells within the brain. In other species, however, the peptide is secreted into hypophysial portal blood to act on pituitary gonadotropes. In particular, a series of studies in sheep have demonstrated potent actions at the level of the pituitary gland to counteract the function of GnRH in terms of the synthesis and secretion of gonadotropins. This review focuses on the action of GnIH at the level of the gonadotrope.
authors.affiliation: Dept Physiology, Monash University, PO Box 13F, Clayton, Vic 3800, Australia. Electronic address: iain.clarke@monash.edu.
authors.forename: Iain J
authors.initials: IJ
authors.lastname: Clarke
authors.affiliation: Dept Physiology, Monash University, PO Box 13F, Clayton, Vic 3800, Australia.
authors.forename: Helena C
authors.initials: HC
authors.lastname: Parkington
mesh_terms: D000818:Animals; D052681:Gonadotrophs / Q000166:cytology / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007028:Hypothalamic Hormones / Q000378:metabolism*; D051379:Mice; D051381:Rats; D012756:Sheep
chemical_list: D006062:Gonadotropins; D007028:Hypothalamic Hormones; C000588859:RFamide-related peptide-3, rat
keywords: Follicle stimulating hormone; Gonadotropin releasing hormone; Hypothalamus; Luteinizing hormone; Pituitary; Reproduction