title: Dose reduction with adaptive statistical iterative reconstruction for paediatric CT: phantom study and clinical experience on chest and abdomen CT.
abstract: OBJECTIVE
  To assess the benefit and limits of iterative reconstruction of paediatric chest and abdominal computed tomography (CT).
  
  
  METHODS
  The study compared adaptive statistical iterative reconstruction (ASIR) with filtered back projection (FBP) on 64-channel MDCT. A phantom study was first performed using variable tube potential, tube current and ASIR settings. The assessed image quality indices were the signal-to-noise ratio (SNR), the noise power spectrum, low contrast detectability (LCD) and spatial resolution. A clinical retrospective study of 26 children (M:F = 14/12, mean age: 4 years, range: 1-9 years) was secondarily performed allowing comparison of 18 chest and 14 abdominal CT pairs, one with a routine CT dose and FBP reconstruction, and the other with 30 % lower dose and 40 % ASIR reconstruction. Two radiologists independently compared the images for overall image quality, noise, sharpness and artefacts, and measured image noise.
  
  
  RESULTS
  The phantom study demonstrated a significant increase in SNR without impairment of the LCD or spatial resolution, except for tube current values below 30-50 mA. On clinical images, no significant difference was observed between FBP and reduced dose ASIR images.
  
  
  CONCLUSIONS
  Iterative reconstruction allows at least 30 % dose reduction in paediatric chest and abdominal CT, without impairment of image quality.
  
  
  CONCLUSIONS
  • Iterative reconstruction helps lower radiation exposure levels in children undergoing CT. • Adaptive statistical iterative reconstruction (ASIR) significantly increases SNR without impairing spatial resolution. • For abdomen and chest CT, ASIR allows at least a 30 % dose reduction.
authors.affiliation: Imaging Department, Institut Curie, 26 rue d'ULM, 75005, Paris, France, frederique.gay1@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Gay
authors.forename: Y
authors.initials: Y
authors.lastname: Pavia
authors.forename: N
authors.initials: N
authors.lastname: Pierrat
authors.forename: S
authors.initials: S
authors.lastname: Lasalle
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
authors.forename: H J
authors.initials: HJ
authors.lastname: Brisse
mesh_terms: D016477:Artifacts; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011860:Radiography, Abdominal / Q000379:methods / Q000592:standards*; D013902:Radiography, Thoracic / Q000379:methods / Q000592:standards*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D059629:Signal-To-Noise Ratio; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards*