title: A new RING tossed into an old HAT.
abstract: p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme's activity.
authors.affiliation: Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Alison E
authors.initials: AE
authors.lastname: Ringel
authors.forename: Cynthia
authors.initials: C
authors.lastname: Wolberger
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D006801:Humans; D050880:p300-CBP Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002843:Chromatin; D050880:p300-CBP Transcription Factors