title: Phenolic compounds with IL-6 inhibitory activity from Aster yomena.
abstract: A new biflavonoid, named asteryomenin (1), as well as six known phenolic compounds, esculetin (2), 4-O-β-D-glucopyranoside-3-hydroxy methyl benzoate (3), caffeic acid (4), isoquercitrin (5), isorhamnetin-3-O-glucoside (6), and apigenin (7) were isolated from the aerial parts of Aster yomena. The structures of compounds (1-7) were identified based on 1D and 2D NMR, including (1)H-(1)H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2-7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell, while compounds 1-3 and 5-6 showed moderate activity.
authors.affiliation: College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju, 501-759, Republic of Korea.
authors.forename: A Ryun
authors.initials: AR
authors.lastname: Kim
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Jin
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Jin
authors.forename: Hae Ju
authors.initials: HJ
authors.lastname: Ko
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D031173:Aster Plant; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D010636:Phenols; D010936:Plant Extracts; D000093242:Interleukin-6 Inhibitors; C508600:IL6 protein, human