title: [Regulatory role of NKT cells in the prevention of type 1 diabetes].
abstract: Type 1 diabetes is an autoimmune disease resulting from the destruction of pancreatic β cells by the immune system. NKT cells are innate-like T cells that can exert potent immuno-regulatory functions. The regulatory role of NKT cells was initially proposed after the observed decreased frequency of this subset in mouse models of type 1 diabetes, as well as in patients developing various autoimmune pathologies. Increasing NKT cell frequency and function prevent the development of type 1 diabetes in mouse models. Several mechanisms including IL-4 and IL-10 production by NKT cells and the accumulation of tolerogenic dendritic cells are critical for the dampening of pathogenic anti-islet T cell responses by NKT cells. Importantly, these cells can at the same time prevent diabetes and promote efficient immune responses against infectious agents. These results strengthen the potential role of NKT cells as a key target for the development of therapeutic strategies against type 1 diabetes.
authors.affiliation: Inserm U1016, Institut Cochin, Paris, France.
authors.forename: Liana
authors.initials: L
authors.lastname: Ghazarian
authors.forename: Yannick
authors.initials: Y
authors.lastname: Simoni
authors.forename: Karine
authors.initials: K
authors.lastname: Pingris
authors.forename: Lucie
authors.initials: L
authors.lastname: Beaudoin
authors.forename: Agnès
authors.initials: A
authors.lastname: Lehuen
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000517:prevention & control*; D005699:Galactosylceramides / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016753:Interleukin-10 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D014777:Virus Diseases / Q000276:immunology
chemical_list: D005699:Galactosylceramides; C493154:alpha-galactosylceramide; D016753:Interleukin-10; D015847:Interleukin-4