title: Antidiabetic activity of mycelia selenium-polysaccharide from Catathelasma ventricosum in STZ-induced diabetic mice.
abstract: Se-polysaccharide from Catathelasma ventricosum (SPC-2) was purified by DEAE-52 and Sephadex G-100 column chromatography. The average size of SPC-2 was 1.6×10(5) Da, and it was mainly composed of glucose (87.4%) with the conformation of β-pyran ring. The branched structure of SPC-2 was proved intuitively by atomic force microscope (AFM). The antidiabetic potential of SPC-2 was tested in STZ-induced diabetic mice. After STZ-induced diabetic mice being administered of SPC-2 for 30 days, SPC-2 treatment significantly reduced the levels of malondialdehyde (MDA) and low-density lipoprotein cholesterol (LDL-C) that were increased by the STZ treatment. Further, the SPC-2 treatment led to increased activity of antioxidant enzymes in liver and kidney and high-density lipoprotein cholesterol (HDL-C) that were decreased by the STZ. The results of histopathology also showed SPC-2 protected tissues (pancreas, liver and kidney) against peroxidation damage and maintained tissue integrity.
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.forename: Shengqi
authors.initials: S
authors.lastname: Rao
authors.forename: Yujie
authors.initials: Y
authors.lastname: Su
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.forename: Caiming
authors.initials: C
authors.lastname: Li
authors.forename: Shude
authors.initials: S
authors.lastname: Xu
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004798:Enzymes / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008813:Mice, Inbred ICR; D009005:Monosaccharides / Q000032:analysis; D025282:Mycelium; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology; D012643:Selenium / Q000737:chemistry / Q000494:pharmacology*; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004798:Enzymes; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D009005:Monosaccharides; D011134:Polysaccharides; D020011:Protective Agents; D013311:Streptozocin; D006003:Glycogen; D012643:Selenium
keywords: Antidiabetic activity; Mushroom; Selenium-polysaccharides; Streptozotocin-induced diabetic mice