title: Outcomes and biochemical parameters following cardiac surgery: effects of transfusion of residual blood using centrifugation and multiple-pass hemoconcentration.
abstract: OBJECTIVE
  To determine whether or not there was a significant difference between the methods of centrifugation (CF) and multiple-pass hemoconcentration (MPH) of the residual cardiopulmonary-bypass volume in relation to biochemical measurements and patient outcomes.
  
  
  METHODS
  Prospective, randomized, and controlled.
  
  
  METHODS
  Conducted at a western Canadian tertiary care hospital.
  
  
  METHODS
  Consisted of 61 consecutive male and female patients from ages 40 to 80 who were scheduled for cardiac surgery with cardiopulmonary bypass.
  
  
  METHODS
  Either the centrifugation or multiple-pass hemoconcentration method was used to process the residual blood from the cardiopulmonary bypass circuit.
  
  
  RESULTS
  The 12-hour postoperative levels of serum hemoglobin were not significantly different in the centrifugation group as compared to the multiple-pass hemoconcentration group. However, the serum levels of total protein and albumin were significantly higher in the multiple-pass hemoconcentration group as compared to the centrifugation group. Additionally, after 12-hours postoperatively, the serum fibrinogen and platelet counts were significantly higher in the multiple-pass hemoconcentration group as compared to those of the centrifugation group. The allogeneic product transfusion index and the chest-tube blood drainage indices were lower in the multiple-pass hemoconcentration group as compared to the centrifugation group.
  
  
  CONCLUSIONS
  Although the CF method provided a product in a shorter turnaround time, with consistent clearance of heparin, the MPH method trended towards enhanced biochemical and clinical patient outcomes over the 12-hour postoperative period.
authors.affiliation: Department of Surgery; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan and Royal University Hospital, Saskatoon, SK, Canada. Electronic address: erick.mcnair@usask.ca.
authors.forename: Erick
authors.initials: E
authors.lastname: McNair
authors.forename: William
authors.initials: W
authors.lastname: McKay
authors.forename: Abdul Mohamed
authors.initials: AM
authors.lastname: Qureshi
authors.forename: Mark
authors.initials: M
authors.lastname: Rosin
authors.forename: Jon
authors.initials: J
authors.lastname: Gamble
authors.forename: Greg
authors.initials: G
authors.lastname: Dalshaug
authors.forename: Taras
authors.initials: T
authors.lastname: Mycyk
authors.forename: Kailash
authors.initials: K
authors.lastname: Prasad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001779:Blood Coagulation Factors / Q000032:analysis; D001803:Blood Transfusion; D001810:Blood Volume; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass; D002498:Centrifugation; D015505:Chest Tubes; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D057725:Operative Blood Salvage / Q000379:methods*; D010976:Platelet Count; D011182:Postoperative Care; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; D006454:Hemoglobins; D012709:Serum Albumin; D005340:Fibrinogen
keywords: allogeneic transfusion; centrifugation; chest tube drainage; multiple-pass hemoconcentration