title: Trafficking of NMDA receptors during status epilepticus: therapeutic implications.
abstract: We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.
authors.affiliation: Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System-West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U.S.A. wasterla@ucla.edu
authors.forename: Claude G
authors.initials: CG
authors.lastname: Wasterlain
authors.forename: David E
authors.initials: DE
authors.lastname: Naylor
authors.forename: Hantao
authors.initials: H
authors.lastname: Liu
authors.forename: Jerome
authors.initials: J
authors.lastname: Niquet
authors.forename: Roger
authors.initials: R
authors.lastname: Baldwin
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D016202:N-Methylaspartate / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013226:Status Epilepticus / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate
keywords: Acute seizures; Cholinergic seizures; Epilepsy; Hippocampus; Monotherapy; NMDA receptor; Receptor trafficking; Status epilepticus