title: A clinical investigation of demineralized bone matrix putty for treatment of periodontal bony defects in humans.
abstract: The goal of this study was to evaluate the effectiveness of demineralized bone matrix (DBM) putty, consisting of demineralized human bone allograft matrix in a carrier of bovine collagen and alginate, for the treatment of periodontal defects in humans. Twenty subjects with at least one site having a probing depth ≥ 6 mm and radiographic evidence of bony defect depth > 3 mm were included. The infrabony defects were grafted with DBM putty bone graft. The following clinical parameters were assessed at baseline and 6 months posttreatment: probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). Bone fill was evaluated using transgingival probing and standardized radiographs taken at baseline and 6 months posttreatment. The 6-month evaluation showed a significant PD reduction of 3.27 ± 1.67 mm and clinical attachment gain of 2.27 ± 1.74 mm. Bone sounding measurements showed a mean clinical bone defect fill of 2.93 ± 1.87 mm and a mean radiographic bone fill of 2.55 ± 2.31 mm. The use of DBM putty was effective for treatment of periodontal bony defects in humans. Significant improvement in CAL, PD, and bone fill was observed at 6 months compared to baseline.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
authors.forename: Arwa Ahmed
authors.initials: AA
authors.lastname: Banjar
authors.forename: Brian L
authors.initials: BL
authors.lastname: Mealey
mesh_terms: D000328:Adult; D000368:Aged; D000464:Alginates; D064591:Allografts; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D002417:Cattle; D003094:Collagen; D003804:Dentin; D005260:Female; D005889:Gingival Recession / Q000000981:diagnostic imaging / Q000601:surgery; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging / Q000601:surgery; D010514:Periodontal Pocket / Q000000981:diagnostic imaging / Q000601:surgery; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000601:surgery*; D011446:Prospective Studies; D011859:Radiography; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D000464:Alginates; D018786:Bone Substitutes; C093073:Demineralized Dentin Matrix; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D003094:Collagen