title: Fungal neuroinfections and fungaemia: unexpected increase of mortality from invasive fungal infections in 2005-2011 in comparison to 1989-1998: analysis of 210 cases.
abstract: OBJECTIVE
  In this short communication we compared the data of fungaemia cases in Slovak hospitals from 1989-1998 published in 1999-2000 with data from 2005-2011.
  
  
  METHODS
  Risk factors, etiology and outcome of fungaemia between two periods (1989-1998 vs. 2005-2011) were compared and risk factors for death assessed by univariate analysis (CDC 2006 Statistical Package).
  
  
  RESULTS
  In comparison to 1989-1998 when only amphotericin B and fluconazole has been used (55%), in 2005-2011 only 35.2% patients received FLU, but 26.4% received voriconazole, 22% caspofungin and anidulafungin and about 6.6% lipid formulations of Amphotericin B. In etiology, while in 1989-1998 only 37.1% (115/310) represented non-albicans Candida (NAC) and non-Candida yeasts in 2005-2011 already reached 63.7%. The significant increase of breakthrough fungaemia may be a sign of inappropriate empiric therapy.
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Demitrovicova
authors.affiliation: Nitra University Hospital, Department of Clinical Microbiology, Nitra, Slovakia.
authors.forename: Anna
authors.initials: A
authors.lastname: Liskova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Michal
authors.initials: M
authors.lastname: Valach
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Izakovic
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Noge
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jana
authors.initials: J
authors.lastname: Baranova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Kalatova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Syrovatkova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jana
authors.initials: J
authors.lastname: Velicova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Beata
authors.initials: B
authors.lastname: Bugykova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Ivica
authors.initials: I
authors.lastname: Gulasova
authors.affiliation: National Cancer Institute and Medical School, Comenius University, Bratislava, Slovakia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Seinova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Gertruda
authors.initials: G
authors.lastname: Mikolasova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Mutalova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Pilkova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Szabo
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Lubica
authors.initials: L
authors.lastname: Findova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Istvan
authors.initials: I
authors.lastname: Madarasz
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Stanzyk
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Mikulickova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Maria
authors.initials: M
authors.lastname: Blazekova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Monika
authors.initials: M
authors.lastname: Jankechova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Slezakova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kuriplachova
authors.affiliation: Jessenius Medical School, Martin, Slovakia.
authors.forename: Jozef
authors.initials: J
authors.lastname: Visnovsky
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Obrocnikova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Mathias
authors.initials: M
authors.lastname: Blumm
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Bernard
authors.initials: B
authors.lastname: Blumm
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Simon
authors.initials: S
authors.lastname: Wolfram
authors.affiliation: St. John Neuman Institute, SEU, Pribram, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Zeleny
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jana
authors.initials: J
authors.lastname: Otrubova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Bruno
authors.initials: B
authors.lastname: Rudinsky
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Nagyova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Vravcova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jozef
authors.initials: J
authors.lastname: Kajaba
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Sona
authors.initials: S
authors.lastname: Jexova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Svetoslav
authors.initials: S
authors.lastname: Oravec
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Slavomir
authors.initials: S
authors.lastname: Toth
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Stanislava
authors.initials: S
authors.lastname: Klobucka
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jana
authors.initials: J
authors.lastname: Gerigh
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Frank
authors.initials: F
authors.lastname: Schumann
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Robert
authors.initials: R
authors.lastname: Ambra
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Bandura
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Christian
authors.initials: C
authors.lastname: Bonnack
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Kubisova
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Marek
authors.initials: M
authors.lastname: Palo
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Erich
authors.initials: E
authors.lastname: Kalavsky
authors.affiliation: National Cancer Institute and Medical School, Comenius University, Bratislava, Slovakia.
authors.forename: Lubos
authors.initials: L
authors.lastname: Drgona
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Rajoo
authors.initials: R
authors.lastname: Mahesvaari
authors.affiliation: St. Elizabeth University, Institute of Tropical Medicine and PhD program, Bratislava, Slovakia.
authors.forename: Jan
authors.initials: J
authors.lastname: Riedl