title: TALENoffer: genome-wide TALEN off-target prediction.
abstract: CONCLUSIONS
  Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes.
  
  
  BACKGROUND
  TALENoffer is available as a command line program from http://www.jstacs.de/index.php/TALENoffer and as a Galaxy server at http://galaxy.informatik.uni-halle.de.
  
  
  BACKGROUND
  grau@informatik.uni-halle.de
authors.affiliation: Institute of Computer Science and Department of Genetics, Institute of Biology, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Grau
authors.forename: Jens
authors.initials: J
authors.lastname: Boch
authors.forename: Stefan
authors.initials: S
authors.lastname: Posch
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D004706:Endodeoxyribonucleases / Q000378:metabolism*; D016678:Genome; D015233:Models, Statistical; D016296:Mutagenesis; D015202:Protein Engineering; D012984:Software
chemical_list: D004268:DNA-Binding Proteins; D004706:Endodeoxyribonucleases