title: Moving RNA moves RNA forward.
abstract: Cell communication affects all aspects of cell structure and behavior, such as cell proliferation, differentiation, division, and coordination of various physiological functions. The moving RNA in plants and mammalian cells indicates that nucleic acid could be one of the various types of messengers for cell communication. The microvesicle is a critical pathway that mediates RNA moving and keeps moving RNA stable in body fluids. When moving miRNA enters the target cell, it functions by altering the gene expression profile and significantly inhibiting mRNA translation in recipient cells. Thus, moving RNA may act as a long-range modulator during development, organogenesis, and tumor metastasis.
authors.affiliation: Key Laboratory of Ministry of Education, Department of Molecular Biology, Fudan University, Shanghai, 200032, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Peng
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Yu
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000235:genetics; D055354:Exosomes / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D034443:RNA Transport; D015398:Signal Transduction / Q000235:genetics; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D012313:RNA