title: [Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium].
abstract: Sixty 60 human papillomavirus (HPV) type 16-positive cervical epithelium biopsy specimens were studied by cytological, histological, immunomorphological, and PCR assays. No correlation was found between proliferation markers and the degree of integration of HPV 16 DNA integration into the cell genome. The number of cells with Ki-67 expression, mitoses, and their alteration was related to the grade of epithelial lesion. Expression of p53 was detected only in the episomal form of HPV DNA and its low integration.
authors.forename: V A
authors.initials: VA
authors.lastname: Ershov
authors.forename: V S
authors.initials: VS
authors.lastname: Chirskiĭ
authors.forename: A A
authors.initials: AA
authors.lastname: Viazovaia
authors.forename: O V
authors.initials: OV
authors.lastname: Narvskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Lisianskaia
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D005786:Gene Expression Regulation; D015894:Genome, Human; D052162:Human papillomavirus 16 / Q000378:metabolism*; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D016662:Virus Integration
chemical_list: D004279:DNA, Viral; D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53