title: Magnetic resonance imaging for diagnosis of early Alzheimer's disease.
abstract: A major challenge for neuroimaging is to contribute to the early diagnosis of Alzheimer's disease (AD). In particular, magnetic resonance imaging (MRI) allows detecting different types of structural and functional abnormalities at an early stage of the disease. Anatomical MRI is the most widely used technique and provides local and global measures of atrophy. The recent diagnostic criteria of "mild cognitive impairment due to AD" include hippocampal atrophy, which is considered a marker of neuronal injury. Advanced image analysis techniques generate automatic and reproducible measures both in the hippocampus and throughout the whole brain. Recent modalities such as diffusion-tensor imaging and resting-state functional MRI provide additional measures that could contribute to the early diagnosis but require further validation.
authors.affiliation: UMR-S975, université Pierre-et-Marie-Curie-Paris-6, centre de recherche de l'institut du cerveau et de la moelle épinière, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; Inserm, U975, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; CNRS, UMR 7225, hôpital de la Pitié-Salpêtrière, bâtiment ICM, 47, boulevard de l'Hôpital, 75013 Paris, France; ICM, institut du cerveau et de la moelle épinière, hôpital de la Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France; INRIA, centre Paris-Rocquencourt, domaine de Voluceau-Rocquencourt, BP 105, 78153 Le Chesnay, France. Electronic address: olivier.colliot@upmc.fr.
authors.forename: O
authors.initials: O
authors.lastname: Colliot
authors.forename: L
authors.initials: L
authors.lastname: Hamelin
authors.forename: M
authors.initials: M
authors.lastname: Sarazin
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D001284:Atrophy / Q000175:diagnosis / Q000473:pathology; D001921:Brain / Q000473:pathology; D060825:Cognitive Dysfunction / Q000175:diagnosis; D056324:Diffusion Tensor Imaging; D042241:Early Diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging
keywords: Alzheimer's disease; Anatomical MRI; Diffusion-tensor imaging; Functional MRI; IRM anatomique; IRM de diffusion; IRM fonctionnelle; Imagerie par résonance magnétique; Magnetic resonance imaging; Maladie d’Alzheimer