title: Inhibitors of the arachidonic acid cascade: interfering with multiple pathways.
abstract: Modulators of the arachidonic acid cascade have been in the focus of research for treatments of inflammation and pain for several decades. Targeting this complex pathway experiences a paradigm change towards the design and development of multi-target inhibitors, exhibiting improved efficacy and less undesired side effects. This minireview summarizes recent developments in the field of designed multi-target ligands of the arachidonic acid cascade. In addition to the well-known dual inhibitors of 5-lipoxygenase and cyclooxygenase-2 such as licofelone, very recent developments are discussed. Especially, multi-target inhibitors interfering with the cytochrome P450 pathway via inhibition of soluble epoxide hydrolase seem to offer a novel opportunity for development of novel anti-inflammatory drugs.
authors.affiliation: Institute of Pharmaceutical Chemistry, OSF/ZAFES/TMP, Goethe-University of Frankfurt, Frankfurt, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Meirer
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhilber
authors.forename: Ewgenij
authors.initials: E
authors.lastname: Proschak
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy; D011758:Pyrroles / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D016859:Lipoxygenase Inhibitors; D011758:Pyrroles; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D001094:Arachidonate 5-Lipoxygenase; D004851:Epoxide Hydrolases; C088092:licofelone