title: Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis.
abstract: The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. β-carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (rs=0.65, rs=0.71 and P<0.05) and copper (rs=0.51, rs=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (rs=-0.49, rs=-0.78 and P<0.05), β-carotene (rs=-0.26, P>0.05; rs=-0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (rs=-0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.
authors.affiliation: Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R.S. Pura 181102, Jammu (J&K), India. Electronic address: shafullah@gmail.com.
authors.forename: S A
authors.initials: SA
authors.lastname: Beigh
authors.forename: J S
authors.initials: JS
authors.lastname: Soodan
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: A M
authors.initials: AM
authors.lastname: Khan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood / Q000201:enzymology*; D004285:Dogs; D005260:Female; D008297:Male; D008924:Mite Infestations / Q000378:metabolism / Q000469:parasitology / Q000662:veterinary*; D014131:Trace Elements / Q000097:blood*
chemical_list: D000975:Antioxidants; D014131:Trace Elements
keywords: Antioxidants; Copper; Iron; Oxidants and vitamin C; β-carotene