title: The stability of lisinopril as an extemporaneous syrup.
abstract: The stability of lisinopril as an extemporaneous syrup compounded from powder was studied. The lisinopril syrup (2mg/mL) was prepared by incorporating lisinopril powder dissolved in water into simple syrup. Samples of the syrup were stored in amber-colored plastic bottles at 5 and 23 deg C. At various times during the 30-day study period, the concentration of lisinopril waas determined by a stability-indicating high performance liquid chromatography assay procedure. Samples were also visually inspeceted for color and clarity. Over the 30-day study period, the percentage of the initial concentration remained between 97.46% and 100.54% for the 23 deg C samples and 98.15% and 100.74% for the 5 deg C samples.
authors.affiliation: Pharmacokinetics Center, McWhorter School of Pharmacy, Samford University, Birmingham, AL.
authors.forename: A A
authors.initials: AA
authors.lastname: Webster
authors.forename: B A
authors.initials: BA
authors.lastname: English
authors.forename: D J
authors.initials: DJ
authors.lastname: Rose