title: Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF.
abstract: OBJECTIVE
  Patients hospitalized for acute heart failure (AHF) differ with respect of many clinical characteristics which may influence their prognosis and response to treatment. We have assessed possible differences in the effects of serelaxin on dyspnoea relief, 60 Day outcomes and 180 Day mortality across patient subgroups in the RELAX-AHF trial.
  
  
  RESULTS
  Subgroups were based on pre-specified covariates (age, sex, race, geographic region, estimated glomerular filtration rate, time from presentation to randomization, baseline systolic blood pressure, history of diabetes, atrial fibrillation, ischaemic heart disease, cardiac devices, i.v. nitrates at randomization). Other covariates which may modify the efficacy of AHF treatment were also analysed. Subgroup analyses did not show any difference in the effects of serelaxin vs. placebo on dyspnoea relief or on the incidence of cardiovascular death or rehospitalizations for heart failure or renal failure at 60 days. Nominally significant interactions between some patient subgroups and the effects of serelaxin on 180 days cardiovascular and all-cause mortality were noted but should be interpreted cautiously due to the number of comparisons and the low incidence of deaths in the subgroups at lower risk.
  
  
  CONCLUSIONS
  The effects of serelaxin vs. placebo appeared to be similar across subgroups of patients in RELAX-AHF.
authors.affiliation: Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Metra
authors.forename: Piotr
authors.initials: P
authors.lastname: Ponikowski
authors.forename: Gad
authors.initials: G
authors.lastname: Cotter
authors.forename: Beth A
authors.initials: BA
authors.lastname: Davison
authors.forename: G Michael
authors.initials: GM
authors.lastname: Felker
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Filippatos
authors.forename: Barry H
authors.initials: BH
authors.lastname: Greenberg
authors.forename: Tsushung A
authors.initials: TA
authors.lastname: Hua
authors.forename: Thomas
authors.initials: T
authors.lastname: Severin
authors.forename: Elaine
authors.initials: E
authors.lastname: Unemori
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Voors
authors.forename: John R
authors.initials: JR
authors.lastname: Teerlink
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002423:Cause of Death; D004311:Double-Blind Method; D004417:Dyspnea / Q000401:mortality / Q000517:prevention & control; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011994:Recombinant Proteins / Q000008:administration & dosage; D012065:Relaxin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D010446:Peptide Fragments; D011994:Recombinant Proteins; C109794:pro-brain natriuretic peptide (1-76); C577649:serelaxin protein, human; D020097:Natriuretic Peptide, Brain; D012065:Relaxin
keywords: Acute heart failure; Mortality; Serelaxin; Subgroups