title: Estrogen responsiveness of progestin receptor induction in the pituitary, preoptic-hypothalamic brain and uterus of neonatally estrogenized female rats.
abstract: Female rats were defeminized by neonatal treatment with estradiol-17beta benzoate, moxestrol (RU 2858), monohydroxytamoxifen ICI 79,280) or the dibenzoate esters of the catecholestrogens, 2-hydroxyestradiol-17beta and 4-hydroxyestradiol-17beta. When ovariectomized as adults and primed with estradiol-17beta benzoate all these rats demonstrated a deficient luteinizing hormone response to progesterone administration. However, estrogen responsiveness of progestin receptor induction was unimpaired in both the pituitary gland, the preoptic-hypothalamic brain and the uterus.
authors.affiliation: Institut für Physiologische Chemie, Universitätsklinikum Essen, D-4300 Essen.
authors.forename: R
authors.initials: R
authors.lastname: Ghraf
authors.forename: J
authors.initials: J
authors.lastname: Kirchhoff
authors.forename: W
authors.initials: W
authors.lastname: Grünke
authors.forename: W
authors.initials: W
authors.lastname: Reinhardt
authors.forename: P
authors.initials: P
authors.lastname: Ball
authors.forename: R
authors.initials: R
authors.lastname: Knuppen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology; D002393:Estrogens, Catechol / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011980:Receptors, Progesterone / Q000378:metabolism*; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D004965:Estrogen Antagonists; D002393:Estrogens, Catechol; D011980:Receptors, Progesterone; D013629:Tamoxifen; C016601:afimoxifene; D004997:Ethinyl Estradiol; D004958:Estradiol; C011310:moxestrol; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol