title: Centrosomes tune in to metabolic state and turn on to oxygen.
abstract: Events required for cell-cycle progression, including centriole duplication and mitotic spindle formation, are obligatorily linked to the metabolic state of a cell. In this issue of Developmental Cell, Moser et al. (2013) show that PHD1 can act as such a sensor through proline hydroxylation of the centrosomal protein Cep192.
authors.affiliation: Department of Pathology and Cancer Institute, NYU School of Medicine, New York, NY 10016, USA.
authors.forename: Sehyun
authors.initials: S
authors.lastname: Kim
authors.forename: Brian D
authors.initials: BD
authors.lastname: Dynlacht
mesh_terms: D002453:Cell Cycle / Q000187:drug effects*; D018385:Centrosome / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology*
chemical_list: C526596:Cep192 protein, human; D002868:Chromosomal Proteins, Non-Histone; C447780:EGLN2 protein, human; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D010100:Oxygen