title: IFITM3 and susceptibility to respiratory viral infections in the community.
abstract: Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, and.
authors.forename: Tara C
authors.initials: TC
authors.lastname: Mills
authors.forename: Anna
authors.initials: A
authors.lastname: Rautanen
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Elliott
authors.forename: Tom
authors.initials: T
authors.lastname: Parks
authors.forename: Vivek
authors.initials: V
authors.lastname: Naranbhai
authors.forename: Margareta M
authors.initials: MM
authors.lastname: Ieven
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Butler
authors.forename: Paul
authors.initials: P
authors.lastname: Little
authors.forename: Theo
authors.initials: T
authors.lastname: Verheij
authors.forename: Chris S
authors.initials: CS
authors.lastname: Garrard
authors.forename: Charles
authors.initials: C
authors.lastname: Hinds
authors.forename: Herman
authors.initials: H
authors.lastname: Goossens
authors.forename: Stephen
authors.initials: S
authors.lastname: Chapman
authors.forename: Adrian V S
authors.initials: AV
authors.lastname: Hill
mesh_terms: D000328:Adult; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000235:genetics; D014777:Virus Diseases / Q000453:epidemiology* / Q000235:genetics
chemical_list: C080082:IFITM3 protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: H1N1; IFITM3; Influenza; LRTI; Virus; association study; genetics; infectious disease