title: Cytotoxic activity of aqueous extracts of Anogeissus leiocarpus and Terminalia avicennioides root barks against Ehrlich ascites carcinoma cells.
abstract: OBJECTIVE
  Folkloric claims on the use of a mixture of Anogeissus leiocarpus and Terminalia avicennioides root barks in tumor management exist without scientific evidence. This study aimed at investigating the phytochemical constituents and in vitro antiproliferative activity of these plants and their mixture.
  
  
  METHODS
  Phytochemical screening was carried out on the aqueous extracts after which various concentrations (0 to 1 000 μg/ml) were incubated with Ehrlich ascites carcinoma cell lines for 3 and 24 hours.
  
  
  RESULTS
  The extracts contained alkaloids, tannins, flavonoids, phenolics, saponins, phlobatannins, and terpenes. The separate extracts and their 1:1 mixture significantly (P<0.05) decreased the computed percentage viability of the cell lines in a dose- and time-dependent manner.
  
  
  CONCLUSIONS
  The antiproliferative activity may be due to the presence of the bioactive compounds in the extracts and has a potential in the management of tumor.
authors.affiliation: Phytomedicine Research Laboratory, Biochemistry and Nutrition Unit, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria.
authors.forename: Amadu Kayode
authors.initials: AK
authors.lastname: Salau
authors.forename: Musa Toyin
authors.initials: MT
authors.lastname: Yakubu
authors.forename: Adenike Temidayo
authors.initials: AT
authors.lastname: Oladiji
mesh_terms: D000470:Alkaloids / Q000032:analysis; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D029764:Combretaceae; D005419:Flavonoids / Q000032:analysis; D051379:Mice; D010636:Phenols / Q000032:analysis; D064209:Phytochemicals / Q000032:analysis; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D012503:Saponins / Q000032:analysis; D013634:Tannins / Q000032:analysis; D029766:Terminalia
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D064209:Phytochemicals; D010936:Plant Extracts; D012503:Saponins; D013634:Tannins
keywords: Anogeissus leiocarpus; Ehrlich ascites carcinoma; Terminalia avicennioides; antiproliferation; phytochemicals