title: A potential association between Toxoplasma gondii infection and schizophrenia in mouse models.
abstract: Schizophrenia is a serious neuropsychiatric disease of uncertain etiology, which causes human mental disorder and affects about 1% of the population. In recently years, some studies showed that some cases of schizophrenia may be associated with Toxoplasma gondii infection. In order to investigate a potential association between Toxoplasma infection and schizophrenia, we investigated the relative clinical symptom of schizophrenia such as learning and memory capability, depression and stereotypy to find some useful information by behavioral test in mouse models. Our results demonstrated that mice from Toxoplasma infection and MK-801 administration (as the model of schizophrenia) were impaired in learning and memory capability, and they had more serious depression and stereotypy compared with the control mice, especially the mice from congenital Toxoplasma infection. In addition, our results clearly showed that the number of cysts in brain tissue of congenital Toxoplasma infection mice was significantly low than in acquired Toxoplasma infected mice. Collectively, these results suggested a potential association between Toxoplasma infection and schizophrenia.
authors.affiliation: Key Laboratory of Jiangxi Province for the Systems Biology Clinical Application, Jiujiang 332000, PR China; Department of Parasitology, School of Basic Medical Sciences, Jiujiang University, Jiujiang 332000, PR China. Electronic address: comwangtaocom@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Zi-hao
authors.initials: ZH
authors.lastname: Tang
authors.forename: Jin-fu
authors.initials: JF
authors.lastname: Li
authors.forename: Xing-nuan
authors.initials: XN
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D001921:Brain / Q000469:parasitology; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D007858:Learning; D008297:Male; D008568:Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D012559:Schizophrenia / Q000139:chemically induced / Q000469:parasitology*; D013239:Stereotyped Behavior; D016781:Toxoplasmosis, Cerebral / Q000150:complications*; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000469:parasitology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate
keywords: Behavior; Mouse models; Schizophrenia; Toxoplasma gondii infection