title: Maladaptive connectivity of Broca's area in schizophrenia during audiovisual speech perception: an fMRI study.
abstract: Speech comprehension relies on auditory as well as visual information, and is enhanced in healthy subjects, when audiovisual (AV) information is present. Patients with schizophrenia have been reported to have problems regarding this AV integration process, but little is known about which underlying neural processes are altered. Functional magnetic resonance imaging was performed in 15 schizophrenia patients (SP) and 15 healthy controls (HC) to study functional connectivity of Broca's area by means of a beta series correlation method during perception of audiovisually presented bisyllabic German nouns, in which audio and video either matched or did not match. Broca's area of SP showed stronger connectivity with supplementary motor cortex for incongruent trials whereas HC connectivity was stronger for congruent trials. The right posterior superior temporal sulcus (RpSTS) area showed differences in connectivity for congruent and incongruent trials in HC in contrast to SP where the connectivity was similar for both conditions. These smaller differences in connectivity in SP suggest a less adaptive processing of audiovisually congruent and incongruent speech. The findings imply that AV integration problems in schizophrenia are associated with maladaptive connectivity of Broca's and RpSTS area in particular when confronted with incongruent stimuli. Results are discussed in light of recent AV speech perception models.
authors.affiliation: Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Hanover, Germany.
authors.forename: G R
authors.initials: GR
authors.lastname: Szycik
authors.forename: Z
authors.initials: Z
authors.lastname: Ye
authors.forename: B
authors.initials: B
authors.lastname: Mohammadi
authors.forename: W
authors.initials: W
authors.lastname: Dillo
authors.forename: B T
authors.initials: BT
authors.lastname: Te Wildt
authors.forename: A
authors.initials: A
authors.lastname: Samii
authors.forename: H
authors.initials: H
authors.lastname: Frieling
authors.forename: S
authors.initials: S
authors.lastname: Bleich
authors.forename: T F
authors.initials: TF
authors.lastname: Münte
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000503:physiopathology; D005790:General Adaptation Syndrome / Q000209:etiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D012559:Schizophrenia / Q000150:complications*; D013067:Speech Perception / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
chemical_list: D010100:Oxygen
keywords: ANOVA; AV; BG; BOLD; EPI; FDR; HC; IC; IFG; RpSTS; SMA; SP; THL; analysis of variance; audiovisual; audiovisual integration; basal ganglia; blood-oxygen-level-dependent; echo planar imaging; fMRI; false discovery rate; functional connectivity; functional magnetic resonance imaging; healthy controls; inferior frontal gyrus; insular cortex; multimodal processing; right posterior superior temporal sulcus; schizophrenia; schizophrenia patients; speech perception; supplementary motor area; thalamus