title: [Oral antiplatelet agents can still be used along with proton pump inhibitors in spite of drug interactions].
abstract: Acetylsalicylic acid and P2Y12-receptor antagonists are antiplatelet agents widely used in the treatment and secondary prevention of cardiovascular disease. Since upper gastrointestinal bleeding is common during antiplatelet treatment, many patients are also treated with a proton pump inhibitor. In recent years it has been heavily discussed if proton pump inhibitors may attenuate the cardiovascular protection achieved with oral antiplatelet agents. Pharmacodynamic studies have suggested important drug interactions, but clinical studies have failed to confirm any clinical impact.
authors.affiliation: Hjertemedicinsk Afdeling, Aarhus Universitetshospital, Brendstrupgaardsvej 100, 8200 Aarhus N. erikgrove@dadlnet.dk.
authors.forename: Morten
authors.initials: M
authors.lastname: Würtz
authors.forename: Erik Lerkevang
authors.initials: EL
authors.lastname: Grove
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D000284:Administration, Oral; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000077144:Clopidogrel; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000068799:Prasugrel Hydrochloride; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D058921:Purinergic P2Y Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D012307:Risk Factors; D058924:Thienopyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D013876:Thiophenes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D000077486:Ticagrelor; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D016861:Cyclooxygenase Inhibitors; D010879:Piperazines; D054328:Proton Pump Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D058924:Thienopyridines; D013876:Thiophenes; D000077144:Clopidogrel; D000068799:Prasugrel Hydrochloride; D000077486:Ticagrelor; D000241:Adenosine; D013988:Ticlopidine; D001241:Aspirin