title: Efficacy of Ceftaroline Fosamil against Escherichia coli and Klebsiella pneumoniae strains in a rabbit meningitis model.
abstract: In this study, the efficacy of ceftaroline fosamil was compared with that of cefepime in an experimental rabbit meningitis model against two Gram-negative strains (Escherichia coli QK-9 and Klebsiella pneumoniae 1173687). The penetration of ceftaroline into inflamed and uninflamed meninges was also investigated. Both regimens were bactericidal, but ceftaroline fosamil was significantly superior to cefepime against K. pneumoniae and E. coli in this experimental rabbit meningitis model (P < 0.0007 against K. pneumoniae and P < 0.0016 against E. coli). The penetration of ceftaroline was approximately 15% into inflamed meninges and approximately 3% into uninflamed meninges.
authors.affiliation: Reha Clinic, Heiligenschwendi, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Stucki
authors.forename: F
authors.initials: F
authors.lastname: Acosta
authors.forename: M
authors.initials: M
authors.lastname: Cottagnoud
authors.forename: P
authors.initials: P
authors.lastname: Cottagnoud
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000494:pharmacology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D007710:Klebsiella Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000502:physiology; D008578:Meninges / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D020814:Meningitis, Escherichia coli / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology; D010539:Permeability; D011817:Rabbits; D016896:Treatment Outcome; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D000077723:Cefepime; D002511:Cephalosporins; D000097583:Ceftaroline