title: Translational research in endocrine surgery.
abstract: This article reviews translational research in endocrine surgery, with a focus on disorders of the thyroid, parathyroids, adrenals, and endocrine pancreas. Discovery of genes responsible for heritable endocrine cancer syndromes has increased knowledge of the causes and mechanisms of endocrine cancer and has refined surgical treatment options. Knowledge of mutations in sporadic cancer has led to rapid progress in small-molecule kinase inhibitor strategies. These breakthroughs and their influence on current therapy are discussed to provide surgeons with an overview of the basic science research currently creating new clinical treatments and improving patient care.
authors.affiliation: Department of Surgery, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
authors.forename: Scott K
authors.initials: SK
authors.lastname: Sherman
authors.forename: James R
authors.initials: JR
authors.lastname: Howe
mesh_terms: D000818:Animals; D013507:Endocrine Surgical Procedures / Q000639:trends*; D004700:Endocrine System Diseases / Q000601:surgery*; D006801:Humans; D057170:Translational Research, Biomedical
keywords: Endocrine cancer; Heritable cancer syndromes; MEN2; Pancreatic neuroendocrine tumors; Thyroid surgery