title: Robotic stereotactic radiosurgery in patients with nasal cavity and paranasal sinus tumors.
abstract: The aim of this retrospective study is to evaluate our therapeutic results in patients with paranasal sinus (PNS) or nasal cavity (NC) malignancies treated with robotic stereotactic radiosurgery (SRS). Between August 2007 and October 2008, 27 patients with PNS or NC tumors were treated in our department using SRS. Median age was 53 years (range, 27-84 years). Eleven patients were female and sixteen were male. Most common histopathology was SCC (44%). The disease involved the maxillary sinus in 15 patients (55%). SRS was applied to 6 patients (22%) for reirradiation, while the others received it as a primary treatment. Seven patients had SRS as a boost dose to external beam radiotherapy. SRS was delivered with cyberknife (Accuray Incorporated, Sunnyvale, CA, USA). The median dose to the tumor was 31 Gy (range, 15-37.5 Gy) in median 5 fractions (range, 3-5 fractions). After a median follow-up of 21.4 months (range, 3-59 months), 76% of the patients were free of local relapse. Three patients showed local progression and 3 developed distant metastases. One- and two-year survival rates for the entire group were 95.2% (SEM = 0.046) and 77.1% (SEM = 0.102), respectively. We observed brain necrosis in 2 patients, visual disorder in 2 patients, bone necrosis in 2 patients and trismus in 1 patient as a SRS related late toxicity. Robotic SRS seems to be a feasible treatment strategy for patients with PNS tumors. Further prospective studies with longer follow up times should be performed.
authors.affiliation: Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, 06100, Turkey. gozyigit@hacettepe.edu.tr.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozyigit
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cengiz
authors.forename: Pervin
authors.initials: P
authors.lastname: Hurmuz
authors.forename: Gozde
authors.initials: G
authors.lastname: Yazici
authors.forename: Melis
authors.initials: M
authors.lastname: Gultekin
authors.forename: Fadil
authors.initials: F
authors.lastname: Akyol
authors.forename: Ferah
authors.initials: F
authors.lastname: Yildiz
authors.forename: Murat
authors.initials: M
authors.lastname: Gurkaynak
authors.forename: Faruk
authors.initials: F
authors.lastname: Zorlu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D065287:Robotic Surgical Procedures / Q000009:adverse effects; D012371:Robotics