title: Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma.
abstract: OBJECTIVE
  To observe effects of trabeculectomy with amniotic membrane transplantation (AMT) in controlling postoperative intraocular pressure (IOP) in patients with medically uncontrolled glaucoma.
  
  
  METHODS
  This study included adult patients with requiring bilateral glaucoma surgery. Each patient underwent trabeculectomy (Non-AMT group) in one eye and with AMT (AMT group) in the other eye according to randomized principle. Success was defined as intraocular pressure (IOP)<21mmHg without any anti-glaucoma medications at 24 months follow-up. The two groups were compared in terms of IOP, complications and success rate.
  
  
  RESULTS
  Thirty-four eyes of 17 patients were investigated in this study. There was no statistically signifcant difference in pre-operative IOP between the two groups. The mean IOP was lower in AMT group compared with Non-AMT group on follow up months 12, 18, and 24.Postoperative complications were more frequent in Non-AMT group (35.3%, 6/17) compared with AMT group (5.9%, 1/17). The success rate of surgery was 88.2% (15/17) in Non-AMT group and 100% (17/17) in AMT group.
  
  
  CONCLUSIONS
  Trabeculectomy with AMT is an effective procedure to reduce IOP and complications, thereby improving surgical success rates.
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Ji
authors.forename: Bing
authors.initials: B
authors.lastname: Qi
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Lao
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Yang
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Wang
authors.forename: Guo-Cheng
authors.initials: GC
authors.lastname: Yu
authors.forename: Jing-Xiang
authors.initials: JX
authors.lastname: Zhong
keywords: amniotic membrane transplantation; glaucoma; trabeculectomy