title: Emerging technologies for metabolite generation and structural diversification.
abstract: Multiple technologies have emerged for structural diversification and efficient production of metabolites of drug molecules. These include expanded use of enzymatic and bioorganic transformations that mimic biological systems, biomimetic catalysis and electrochemical techniques. As this field continues to mature the breadth of transformations is growing beyond simple oxidative processes due in part to parallel development of more efficient catalytic methods for functionalization of unactivated scaffolds. These technologies allow for efficient structural diversification of both aromatic and aliphatic substrates in many cases via single step reactions without the use of protecting groups.
authors.affiliation: AbbVie Bioresearch Center, 381 Plantation Street, Worcester, MA 01605, USA. Electronic address: kevin.cusack@abbvie.com.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Cusack
authors.forename: Hannes F
authors.initials: HF
authors.lastname: Koolman
authors.forename: Udo E W
authors.initials: UE
authors.lastname: Lange
authors.forename: Hillary M
authors.initials: HM
authors.lastname: Peltier
authors.forename: Isabel
authors.initials: I
authors.lastname: Piel
authors.forename: Anil
authors.initials: A
authors.lastname: Vasudevan
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D055664:Electrochemical Techniques; D006801:Humans; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D013237:Stereoisomerism
chemical_list: D011994:Recombinant Proteins; D003577:Cytochrome P-450 Enzyme System
keywords: Biomimetic oxidation; Catalytic transformation; Cytochrome P450; Electrochemistry; Enzymatic transformation; FXTIYMYTRIFRKL-RFGMYIJVSA-K; Fluorination; LPGJQKSJOQRXJT-YOAFYNBBSA-N; Metabolism; Metalloporphyrin; Microbial metabolism; OETMRHBYSHRNMU-UHFFFAOYSA-N; QAGYKUNXZHXKMR-HKWSIXNMSA-N; SAMJTHBMAUMJNB-UHFFFAOYSA-N; SINGGCIFJHSECQ-PFVZUNBHSA-N; VDBQDONUIAOUOC-SKXVCGILSA-N; WPRSCLYSKGPDBZ-UHFFFAOYSA-N