title: Polydimethylsiloxane/metal-organic frameworks coated stir bar sorptive extraction coupled to high performance liquid chromatography-ultraviolet detector for the determination of estrogens in environmental water samples.
abstract: In this work, three kinds of metal-organic frameworks (MOFs), MOF-5, MOF-199 and IRMOF-3, were introduced in stir bar sorptive extraction (SBSE) and novel polydimethylsiloxane (PDMS)/MOFs (including PDMS/MOF-5, PDMS/MOF-199 and PDMS/IRMOF-3) coated stir bars were prepared by sol-gel technique. These PDMS/MOFs coatings were characterized and critically compared for the extraction of seven target estrogens (17-β-estradiol, dienestrol, diethylstilbestrol, estrone, 4-t-octylphenol, bisphenol-A and 17α-ethynylestradiol) by SBSE, and the results showed that PDMS/IRMOF-3 exhibited highest extraction efficiency. Based on the above facts, a novel method of PDMS/IRMOF-3 coating SBSE-high performance liquid chromatography ultraviolet (HPLC-UV) detection was developed for the determination of seven target estrogens in environmental waters. Several parameters affecting extraction of seven target estrogens by SBSE (PDMS/IRMOF-3) including extraction time, stirring rate, pH, ionic strength, desorption solvent and desorption time were investigated. Under the optimal experimental conditions, the limits of detection (LODs, S/N=3) were found to be in the range of 0.15-0.35 μg/L. The linear range was 2-2,500 μg/L for 17α-ethynylestradiol and 1-2,500 μg/L for other estrogens. The relative standard deviations (RSDs) were in the range of 3.7-9.9% (n=8, c=20 μg/L) and the enrichment factors were from 30.3 to 55.6-fold (theoretical enrichment factor was 100-fold). The proposed method was successfully applied to the analysis of estrogens in environmental water samples, and quantitative recoveries were obtained for the spiking experiments.
authors.affiliation: Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Hu
authors.forename: Man
authors.initials: M
authors.lastname: He
authors.forename: Beibei
authors.initials: B
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004967:Estrogens / Q000032:analysis* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D016014:Linear Models; D000432:Methanol; D009942:Organometallic Compounds / Q000737:chemistry; D009994:Osmolar Concentration; D015203:Reproducibility of Results; D045483:Rivers / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D004129:Dimethylpolysiloxanes; D004967:Estrogens; D009942:Organometallic Compounds; D014874:Water Pollutants, Chemical; C013830:baysilon; D000432:Methanol
keywords: Environmental water samples; Estrogens; HPLC-UV; PDMS/MOFs coating; SBSE