title: Pathogenesis and medical management of diabetic Charcot neuroarthropathy.
abstract: The Charcot foot is a problematic clinical entity that worsens in the absence of timely intervention. As of now, based on the ADA consensus report, offloading with TCC continues to remain the mainstay of therapy for CN.1 A standardized approach to the management of CN is depicted in Fig. 1. Furthermore, ongoing inflammatory activity can be controlled with antiresorptive agents, like BPPs and calcitonin; however, data acquired from larger trials with these agents are awaited. Newer agents that target the inflammatory cascade have been identified and applied in limited clinical trials in non-Charcot conditions. Their potential role in the future management of CN has yet to be established.
authors.affiliation: Department of Endocrinology, St. John's National Academy of Health Sciences, Bangalore 560034, Karnataka, India.
authors.forename: Janice V
authors.initials: JV
authors.lastname: Mascarenhas
authors.forename: Edward B
authors.initials: EB
authors.lastname: Jude
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001177:Arthropathy, Neurogenic / Q000150:complications / Q000628:therapy*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002116:Calcitonin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000150:complications / Q000628:therapy*; D018450:Disease Progression; D005528:Foot / Q000503:physiopathology*; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D011379:Prognosis; D035583:Rare Diseases
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D050071:Bone Density Conservation Agents; D002116:Calcitonin
keywords: Bisphosphonates (BPPs); Calcitonin; Charcot neuroarthropathy; Diabetic neuropathy; RANKL pathway; Total contact cast