title: Hypertriglyceridemia is frequent in endometrial cancer survivors.
abstract: OBJECTIVE
  Previous studies have reported an association between endometrial cancer and the risk of metabolic syndrome; however, the pattern of endometrial cancer-associated dyslipidemia is not well understood. The standard therapy for endometrial cancer is total abdominal hysterectomy and bilateral salpingo-oophorectomy. Premenopausal bilateral salpingo-oophorectomy may cause adverse events, including dyslipidemia. Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.
  
  
  METHODS
  This study included 693 patients who had undergone bilateral salpingo-oophorectomy, and included 412 women with incident endometrial cancer and 281 controls. We divided the patients into two categories according to whether they had a premenopausal or postmenopausal bilateral oophorectomy. Serum lipid levels were measured and statistically analyzed.
  
  
  RESULTS
  Hypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls. High levels of low-density lipoprotein cholesterol and a high low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy before menopause than in non-endometrial cancer controls.
  
  
  CONCLUSIONS
  Our report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.
authors.affiliation: *Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan. hir-aki@z8.keio.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Hirasawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Makita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Akahane
authors.forename: Megumi
authors.initials: M
authors.lastname: Yokota
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamagami
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D016889:Endometrial Neoplasms / Q000150:complications* / Q000601:surgery*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause; D017697:Premenopause; D058994:Salpingectomy; D017741:Survivors / Q000706:statistics & numerical data*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids
keywords: cancer survivor; dyslipidemia; endometrial cancer; hypertriglycemia