title: Cancer immunotherapy: current status and future directions.
abstract: Better understanding of the underlying principles of tumor biology and immunology, enhanced by recent insights into the mechanisms of immune recognition, regulation, and tumor escape has provided new approaches for cancer immunotherapy. This article reviews the current status and future directions of cancer immunotherapy, with a focus on the recent encouraging results from immune-modulating antibodies and adoptive cell therapy.
authors.affiliation: Department of Surgery, University of Michigan Health System, 3410 Cancer Center/5932, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5932, USA.
authors.forename: Fumito
authors.initials: F
authors.lastname: Ito
authors.forename: Alfred E
authors.initials: AE
authors.lastname: Chang
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines
keywords: Adoptive cell therapy; Cancer immunotherapy; Cancer vaccine; Immune checkpoints; Immune-modulating antibodies