title: Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia.
abstract: The oil of babassu tree nuts (Orbignya speciosa) is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. The main objective of this work was the preparation and characterization of poly(lactic-co-glycolic acid) (PLGA) nanoparticle and clay nanosystems containing babassu oil (BBS). BBS was extracted from the kernels of babassu tree nuts and characterized by gas chromatography-mass spectrometry as well as 1H and 13C nuclear magnetic resonance. BBS-clay nanosystems were obtained by adding polyvinylpyrrolidone, Viscogel B8®, and BBS at a 2:1:1 mass ratio and characterized by X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, and laser diffraction. The PLGA-BBS nanoparticles were prepared by the precipitation-solvent evaporation method. Mean diameter, polydispersity, zeta potential, and scanning electron microscopic images of the nanosystems were analyzed. Thermogravimetric analysis showed successful formation of the nanocomposite. PLGA nanoparticles containing BBS were obtained, with a suitable size that was confirmed by scanning electron microscopy. Both nanostructured systems showed active incorporation yields exceeding 90%. The two systems obtained represent a new and potentially efficient therapy for benign prostatic hyperplasia.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. valeria@pharma.ufrj.br
authors.forename: Valeria Pereira
authors.initials: VP
authors.lastname: de Sousa
authors.forename: Joanne
authors.initials: J
authors.lastname: Crean
authors.forename: Vinícius Raphael
authors.initials: VR
authors.lastname: de Almeida Borges
authors.forename: Carlos Rangel
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Lidia
authors.initials: L
authors.lastname: Tajber
authors.forename: Fabio
authors.initials: F
authors.lastname: Boylan
authors.forename: Lucio Mendes
authors.initials: LM
authors.lastname: Cabral
mesh_terms: D028023:Arecaceae / Q000737:chemistry*; D019344:Lactic Acid; D053761:Nanocomposites / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry* / Q000493:pharmacokinetics; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D010938:Plant Oils; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: babassu oil; benign prostatic hyperplasia; nanocomposite; nanoparticles; nanotechnology; poly(lactic-co-glycolic acid); treatment