title: Molecular control of the NEMO family of ubiquitin-binding proteins.
abstract: Research over the past decade has revealed how NF-κB essential modulator (NEMO; also known as IKKγ) regulates the IKKα-IKKβ signalling axis in the innate immune system. The discovery that NEMO is a polyubiquitin-binding protein and that the IKK complex is modulated by other protein kinases that are themselves controlled by polyubiquitin chains has provided a deeper molecular understanding of the non-degradative roles of ubiquitylation. New mechanistic insights of NEMO and related polyubiquitin-binding proteins have become a paradigm for how the interplay between phosphorylation and ubiquitylation controls cell signalling networks in health and disease.
authors.affiliation: Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.
authors.forename: Kristopher
authors.initials: K
authors.lastname: Clark
authors.forename: Sambit
authors.initials: S
authors.lastname: Nanda
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
mesh_terms: D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics* / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D025821:Polyubiquitin / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D025821:Polyubiquitin; D051550:I-kappa B Kinase