title: Population-based 5-year follow-up study in Taiwan of osteoporosis and risk of periodontitis.
abstract: BACKGROUND
  Osteoporosis and periodontitis are both considered global health issues that threaten postmenopausal women and the older population. However, the correlation between osteoporosis and periodontitis is still unclear.
  
  
  METHODS
  Using a nationwide Taiwanese population-based database, data from patients with osteoporosis (2003 to 2005; n = 2,527) and 7,575 individuals who were matched to each patient by age and sex were analyzed. All participants were tracked for 5 years from the date of enrollment to observe the percentage of patients who developed periodontitis. Cox proportional hazard regressions were performed to evaluate 5-year periodontitis-free survival rates.
  
  
  RESULTS
  Among the total sample, 3,060 individuals were diagnosed with periodontitis during the 5-year follow-up period: 792 in the study cohort and 2,268 in the comparison cohort. The adjusted hazard ratio for periodontitis in patients with osteoporosis compared with individuals without osteoporosis during the 5-year follow-up was 1.14 (95% confidence interval = 1.05 to 1.24, P <0.01).
  
  
  CONCLUSIONS
  This population-based study indicated that patients with osteoporosis may have an increased risk of periodontitis.
authors.affiliation: Department of Healthcare Management, Yuanpei University, HsinChu, Taiwan.
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.forename: Mei-Shin
authors.initials: MS
authors.lastname: Wu
authors.forename: Jei-Tsung
authors.initials: JT
authors.lastname: Pai
authors.forename: Yuh-Cherng
authors.initials: YC
authors.lastname: Guo
authors.forename: Ku-Chung
authors.initials: KC
authors.lastname: Chen
authors.forename: Mu-En
authors.initials: ME
authors.lastname: Liu
authors.forename: Wen-Ta
authors.initials: WT
authors.lastname: Chiu
authors.forename: Kuo-Sheng
authors.initials: KS
authors.lastname: Hung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D010520:Aggressive Periodontitis / Q000453:epidemiology; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000453:epidemiology; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005891:Gingivitis / Q000453:epidemiology; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007182:Income / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology*; D010518:Periodontitis / Q000453:epidemiology*; D011159:Population Surveillance; D016016:Proportional Hazards Models; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D014507:Urbanization