title: Secondary metabolites from the soft coral Sinularia arborea.
abstract: Two new 13-hydroxycembrane diterpenoids, arbolides A (1) and B (2), along with a known trihydroxysteroid, crassarosterol A (3), were isolated from the soft coral Sinularia arborea. The structures of new cembranes 1 and 2 were elucidated by spectroscopic methods. Steroid 3 was found to exhibit cytotoxicity toward K562 and MOLT-4 leukemia.
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Kuan-Hua
authors.initials: KH
authors.lastname: Chen
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.forename: Jan-Jung
authors.initials: JJ
authors.lastname: Li
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Yu-Chia
authors.initials: YC
authors.lastname: Chang
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Su
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes