title: Season of diagnosis and survival of advanced lung cancer cases--any correlation?
abstract: BACKGROUND
  The influence of season at diagnosis on cancer survival has been an intriguing issue for many years. Most studies have shown a possible correlation in between the seasonality and some cancer type survival. With short expected survival, lung cancer is an arena that still is in need of new prognostic factors and models. We aimed to investigate the effect of season of diagnosis on 3 months, 1 and 2 years survival rates and overall survival of non small cell lung cancer patients.
  
  
  METHODS
  The files of non small cell lung cancer patients that were stages IIIB and IV at diagnosis were reviewed retrospectively. According to diagnosis date, the patients were grouped into 4 season groups, autumn, winter, spring and summer.
  
  
  RESULTS
  A total of 279 advanced non small cell lung cancer patients' files were reviewed. Median overall survival was 15 months in the entire population. Overall 3 months, 1 and 2 years survival rates were 91.0%, 58.2% and 31.2% respectively. The season of diagnosis was significantly correlated with 3 months survival rates, being diagnosed in spring being associated with better survival . Also the season was significantly correlated with T stage of the disease. For 1 and 2 years survival rates and overall survival, the season of diagnosis was not significantly correlated. There was no correlation detected between season and overall survivals according to histological subtypes of non small cell lung cancer.
  
  
  CONCLUSIONS
  As a new finding in advanced non small cell lung cancer patients, it can be concluded that being diagnosed in spring can be a favorable prognostic factor for short term survival.
authors.affiliation: Medical Oncology Department, Faculty of Medicine, Baskent University, Turkey. oguzarzu@yahoo.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Oguz
authors.forename: Dilek
authors.initials: D
authors.lastname: Unal
authors.forename: Neslihan
authors.initials: N
authors.lastname: Kurtul
authors.forename: Fatma
authors.initials: F
authors.lastname: Aykas
authors.forename: Hasan
authors.initials: H
authors.lastname: Mutlu
authors.forename: Hatice
authors.initials: H
authors.lastname: Karagoz
authors.forename: Ali
authors.initials: A
authors.lastname: Cetinkaya
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018287:Carcinoma, Large Cell / Q000401:mortality* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012621:Seasons; D015996:Survival Rate