title: Sibutramine-associated psychotic symptoms and zolpidem-induced complex behaviours: implications for patient safety.
abstract: BACKGROUND
  Sibutramine is a weight loss agent recently withdrawn from the European market due to cardiovascular risk concerns. It was used for long-term obesity treatment. Zolpidem is a short acting hypnotic agent commonly used in the treatment of insomnia. A number of case reports describing psychotic reaction to sibutramine were reported in the literature.
  
  
  METHODS
  We present a case of a 61-year-old Caucasian woman who developed two psychotic episodes related to sibutramine treatment. The second psychotic episode was complicated with complex behaviours after zolpidem use due to insomnia. Sibutramine and zolpidem discontinuation resulted in rapid resolution of psychotic symptoms.
  
  
  CONCLUSIONS
  This case suggests a possibility of incidence of psychotic symptoms and complex behaviour disturbances in patients prescribed sibutramine or other monoaminergic reuptake inhibitors.
authors.affiliation: Department of Psychiatry, Medical University of Gdańsk, Dębinki St. 7 build. 25, 80-952 Gdańsk, Poland, mwiglusz@gumed.edu.pl.
authors.forename: Mariusz S
authors.initials: MS
authors.lastname: Wiglusz
authors.forename: Wiesław Jerzy
authors.initials: WJ
authors.lastname: Cubała
authors.forename: Paweł
authors.initials: P
authors.lastname: Nowak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jakuszkowiak-Wojten
authors.forename: Jerzy
authors.initials: J
authors.lastname: Landowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krysta
mesh_terms: D001067:Appetite Depressants / Q000009:adverse effects*; D003503:Cyclobutanes / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D011725:Pyridines / Q000009:adverse effects*; D000077334:Zolpidem
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem; C058254:sibutramine