title: Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma.
abstract: BACKGROUND
  An increased body mass index (BMI) is significantly associated with favourable prognosis in renal cell carcinoma (RCC). This study investigated the associations among sex, BMI, and prognosis in clear cell RCC patients.
  
  
  METHODS
  We retrospectively analysed 435 patients with clear cell RCC who underwent a nephrectomy. The associations among sex, BMI, clinicopathologic factors, and cancer-specific survival (CSS) were analysed.
  
  
  RESULTS
  As a continuous variable, increased BMI was associated with higher CSS rate by univariate analysis in the whole population (hazard ratio, 0.888 per kg m(-2); 95% confidence interval, 0.803-0.982; P=0.021). A sub-population analysis by sex demonstrated that BMI was significantly associated with CSS in men (P=0.004) but not in women (P=0.725). Multivariate analysis revealed BMI to be an independent predictor of CSS in only men.
  
  
  CONCLUSIONS
  Body mass index was significantly associated with clear cell RCC prognosis. However, the clinical value of BMI may be different between men and women.
authors.affiliation: Department of Urology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 1600023, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohno
authors.forename: J
authors.initials: J
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagami
authors.forename: N
authors.initials: N
authors.lastname: Satake
authors.forename: T
authors.initials: T
authors.lastname: Gondo
authors.forename: M
authors.initials: M
authors.lastname: Ohori
authors.forename: T
authors.initials: T
authors.lastname: Hatano
authors.forename: M
authors.initials: M
authors.lastname: Tachibana
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies; D012727:Sex Characteristics; D015996:Survival Rate; D016896:Treatment Outcome