title: Hematologic and bone marrow changes in children with protein-energy malnutrition.
abstract: BACKGROUND
  All systems in an organism are affected by protein-energy malnutrition (PEM), but one of the worst affected is the hematopoietic system. Today PEM remains a very serious problem in developing countries. We examined the relationships between clinical features, hematological, and bone marrow changes with severe PEM from Turkey.
  
  
  METHODS
  We evaluated 34 (11 females and 23 males) consecutive cases of severe PEM, with no underlying diseases aged 3-20 months. The clinical nutritional conditions of the patients were determined using the Wellcome-Trust PEM classification. Ten of the patients were in the Marasmic-Kwashiorkor (M-K) group, 10 were in the Kwashiorkor (KW) group, and 14 were in the Marasmic (M) group. Full blood count, protein, albumin, serum iron (SI), iron-binding capacity (TIBC), ferritin, vitamin B12, folic acid, complement-3 (C3), complement-4 (C4), and bone marrow were investigated in all groups.
  
  
  RESULTS
  Anemia was detected in 97% of patients. We determined serum iron levels were low in 67.6% of the patients, TS levels were low in 76.4% of the patients and ferritin levels were low in 20.5%. The level of vitamin B12 was normal in all patients. Bone marrow analysis showed erythroid series hypoplasia in 28.5% of patients in the M group, 50% in the KW group, and 30% in the M-K group. Marrow iron was absent in 58.8% of patients.
  
  
  CONCLUSIONS
  The most common hematologic change in the children with PEM was anemia and major cause of anemia was iron deficiency in this study. Patients with severe PEM have normal Vit B12 and serum folate levels. Most of the patients with severe PEM had normal cellularity with megaloblastic and dysplastic changes in bone marrow due to the inadequate and imbalanced intake of protein and energy.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Baskent University , Adana , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Özkale
authors.forename: Tansu
authors.initials: T
authors.lastname: Sipahi
mesh_terms: D000740:Anemia / Q000097:blood / Q000473:pathology; D001798:Blood Proteins / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D015362:Child Nutrition Disorders / Q000097:blood / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000097:blood / Q000473:pathology; D007501:Iron / Q000097:blood; D008297:Male; D011488:Protein Deficiency / Q000097:blood / Q000401:mortality; D014421:Turkey; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D001798:Blood Proteins; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12