title: Effects of resistance training on central blood pressure in obese young men.
abstract: Central blood pressure is a predictor of the risk of cardiovascular disease (CVD), and the effects of resistance training (RT) on central blood pressure are largely unknown. This study explored the effects of high-intensity RT on central blood pressure, indices of arterial stiffness and wave reflection and inflammatory/atherogenic markers in overweight or obese, sedentary young men. Thirty-six participants were randomized to RT (12 weeks of training, 3/wk, n=28) or control groups (C, 12 weeks of no training, n=8) and assessed for changes in central and brachial blood pressures, augmentation index (AIx), carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT), body composition, lipids and inflammatory/atherogenic markers. High-intensity RT resulted in decreased central and brachial systolic/diastolic blood pressures (all P0.03), despite not altering AIx (P=0.34) or cfPWV (P=0.43). The vascular endothelial growth factor increased (P=0.03) after RT, without any change in cIMT, C-reactive protein, oxidized LDL (oxLDL) or other inflammatory markers (all P0.1). Changes in the central systolic blood pressure (cSBP) were positively correlated with changes in oxLDL (r=0.42, P=0.03) and soluble E-selectin (r=0.41, P=0.04). In overweight/obese young men, high-intensity RT decreases cSBP, independently of weight loss and changes in arterial stiffness. The cardioprotective effects of RT may be related to effects on central blood pressure.
authors.affiliation: 1] David Geffen School of Medicine, University of California, Los Angeles, CA, USA [2] Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Croymans
authors.affiliation: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Krell
authors.affiliation: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Oh
authors.affiliation: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Katiraie
authors.affiliation: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Lam
authors.affiliation: Georgia Prevention Institute, Georgia Health Sciences University, Augusta, GA, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Harris
authors.affiliation: Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, CA, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Roberts
mesh_terms: D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D059168:Carotid Intima-Media Thickness; D004562:Electrocardiography; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000503:physiopathology; D055070:Resistance Training; D057185:Sedentary Behavior; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers