title: Low ankle-brachial index predicts new vascular events and functional outcome after 1 year in patients with non-cardioembolic stroke: our experience and review.
abstract: OBJECTIVE
  The ankle-brachial index (ABI) has been defined as an important factor associated with vascular events. Our objective was to analyze the prognostic value of the ABI as a predictive factor of new vascular events and functional status at 1 year in patients with non-cardioembolic ischaemic stroke.
  
  
  METHODS
  A prospective, longitudinal, observational and multicenter study was performed, including consecutive patients ≥ 50 years old who had suffered from a non-cardioembolic ischaemic stroke. Pathological ABI (PI) was defined when the value was ≤ 0.9. The logistic regression model, survival analysis and the Cox proportional hazard regression model were used to identify factors independently associated with functional outcome and occurrence of new vascular events, including recurrent stroke.
  
  
  RESULTS
  In all, 977 patients were evaluated. The mean age was 69.1 ± 9.5 years. 40.5% patients had PI. Stroke recurrence and new vascular events global rates were 9% and 20% respectively at 1 year. PI was independently associated with new vascular events [hazard ratio 1.764 (1.274-2.444), P = 0.001]. A cut-off point of ABI ≤ 0.8 (14% vs. 7%, P = 0.002) independently predicted stroke recurrence in an adjusted regression model [hazard ratio 1.807 (1.102-2.963), P = 0.019]. PI was also associated with functional dependence [odds ratio 1.490 (1.011-2.196), P = 0.044].
  
  
  CONCLUSIONS
  In non-cardioembolic ischaemic stroke patients, PI was an independent predictive factor of new vascular events and functional outcome after 1 year of follow-up.
authors.affiliation: Neurovascular Unit, Department of Neurology, Universitat Autònoma de Barcelona, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Sabín
authors.forename: M
authors.initials: M
authors.lastname: Quintana
authors.forename: E
authors.initials: E
authors.lastname: Santamarina
authors.forename: O
authors.initials: O
authors.lastname: Maisterra
authors.forename: A
authors.initials: A
authors.lastname: Gil-Núñez
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D020127:Recovery of Function; D012008:Recurrence; D020521:Stroke / Q000150:complications / Q000453:epidemiology* / Q000401:mortality
keywords: ankle−brachial index; atherothrombotic stroke; outcome; recurrence; stroke