title: Antifungal therapy with an emphasis on biofilms.
abstract: Fungal infections are on the rise as advances in modern medicine prolong the lives of severely ill patients. Fungi are eukaryotic organisms and there are a limited number of targets for antifungal drug development; as a result the antifungal arsenal is exceedingly limited. Azoles, polyenes and echinocandins constitute the mainstay of antifungal therapy for patients with life-threatening mycoses. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, microbial communities displaying resistance to most antifungal agents. A better understanding of fungal biofilms provides for new opportunities for the development of urgently needed novel antifungal agents and strategies.
authors.affiliation: Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA; South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Pierce
authors.forename: Anand
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Priya
authors.initials: P
authors.lastname: Uppuluri
authors.forename: Anand K
authors.initials: AK
authors.lastname: Ramasubramanian
authors.forename: José L
authors.initials: JL
authors.lastname: López-Ribot
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D005658:Fungi / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009181:Mycoses / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents