title: The two faces of DNA repair: disease and therapy.
abstract: Our genome is the blueprint for our bodies. A number of sophisticated mechanisms help protect our genome from life-threatening cellular mistakes and environmental insults. Much current research focuses on understanding these mechanisms, how they prevent disease, and whether they can be targeted for therapeutic purposes. Here, we review the main mechanisms maintaining genome integrity, how their malfunctioning results in disease, and the exciting progress toward targeting these mechanisms for cancer treatments.
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, USA. avindign@slu.edu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vindigni
authors.forename: Susana
authors.initials: S
authors.lastname: Gonzalo
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D059004:Topoisomerase I Inhibitors / Q000494:pharmacology
chemical_list: D059004:Topoisomerase I Inhibitors