title: Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome).
abstract: OBJECTIVE
  To report the first live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from a man with Eagle-Barrett syndrome (EBS).
  
  
  METHODS
  Case report.
  
  
  METHODS
  Assisted conception unit within a private hospital.
  
  
  METHODS
  An infertile couple.
  
  
  METHODS
  An infertile couple received repeated treatment with ICSI.
  
  
  METHODS
  Clinical pregnancy and a normal live birth.
  
  
  RESULTS
  In 2008, after microinjection of ten oocytes, the transfer of a single expanded blastocyst led to the premature birth of a morphologically normal male infant at 18 weeks' gestation. This outcome followed preterm rupture of membranes and possible cervical incompetence. In 2009, after microinjection of six oocytes, transfer of a single 5-cell embryo led to a singleton pregnancy, with emergency cervical cerclage being performed at 21 weeks. A healthy male infant was born at 30 weeks, with no evidence of EBS, by lower-segment cesarean section for breech presentation and premature labor. In 2012, after elective laparoscopic placement of cervical suture, microinjection of ten oocytes and transfer of a single 4-cell embryo led to a singleton pregnancy with a healthy male infant, with no evidence of EBS, being born by cesarean section at 38 weeks.
  
  
  CONCLUSIONS
  This report suggests that EBS is not transmitted to male offspring via ICSI.
authors.affiliation: Assisted Conception Australia, Greenslopes Private Hospital, Brisbane, Queensland, Australia; School of Medicine, University of Queensland, Brisbane, Queensland, Australia. Electronic address: blueyfleming@gmail.com.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Fleming
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Varughese
authors.forename: Vi-Khiem
authors.initials: VK
authors.lastname: Hua
authors.forename: Amanda
authors.initials: A
authors.lastname: Robertson
authors.forename: Fiona
authors.initials: F
authors.lastname: Dalzell
authors.forename: Clare V
authors.initials: CV
authors.lastname: Boothroyd
mesh_terms: D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007246:Infertility / Q000235:genetics* / Q000628:therapy*; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011535:Prune Belly Syndrome / Q000235:genetics* / Q000628:therapy*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D016896:Treatment Outcome
keywords: Eagle-Barrett syndrome (prune belly); intracytoplasmic sperm injection (ICSI); orchidopexy