title: Oncometabolites: linking altered metabolism with cancer.
abstract: The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
authors.affiliation: Cancer Biology and Metabolism Group, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Soga
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Pollard
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002264:Carboxylic Acids / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D044127:Epigenesis, Genetic; D005649:Fumarate Hydratase / Q000235:genetics; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D002264:Carboxylic Acids; D013385:Succinate Dehydrogenase; D005649:Fumarate Hydratase