title: [Research advances in molecular pathogenesis of thyroid cancer].
abstract: Thyroid cancer is the one of the most common endocrine tumors. The biological behaviors and prognoses of the thyroid cancer of different histological types remarkably differ. The highly invasive thyroid cancer responds poorly to traditional therapies. Recent research advances in the molecular mechanisms of the pathogenesis of thyroid cancer have revealed the roles of many genetic and epigenetic variations such as gene mutation, abnormal gene amplification, and abnormal gene methylation in the development of thyroid cancer, which provides new insights in the molecular diagnosis, prognosis, and target therapy of the thyroid cancer.
authors.affiliation: Department of General Surgery, PUMC Hospital, Beijing, China.
authors.forename: Maotihan
authors.initials: M
authors.lastname: Aleha
authors.forename: Qing-bin
authors.initials: QB
authors.lastname: Meng
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Yu
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Kang
authors.forename: Zhan-jiang
authors.initials: ZJ
authors.lastname: Cao
authors.forename: Shu-bo
authors.initials: SB
authors.lastname: Tian
mesh_terms: D002277:Carcinoma / Q000235:genetics*; D006801:Humans; D009154:Mutation; D015398:Signal Transduction; D013964:Thyroid Neoplasms / Q000235:genetics*