title: [Inactivation of feline calicivirus by chlorine dioxide gas-generating gel].
abstract: Noroviruses are one of the most important causes of acute gastroenteritis throughout the world. The aim of this study is to evaluate the efficacy of a chlorine dioxide gas-generating gel (ClO2 gel, 60 g) against feline calicivirus (FCV), a norovirus surrogate, in the wet state on glass dishes in a test sink (43 cm long, 75 cm wide, and 29 cm deep). The ClO2 gel permits sustained release of gaseous ClO2 (1.7 mg/h at 25°C), and was placed in one corner of the test sink. The glass dishes containing FCV suspension were placed at three positions in the test sink. We demonstrated that FCV was inactivated within 5h (>2 or >3 log10 reductions at three positions, n=20) in the test sink where the ClO2 gel was placed. These small quantities of ClO2 gel might be a useful tool for reducing the risk of infection by norovirus in wet environments such as kitchens and bathrooms under optimal condition.
authors.affiliation: Taiko Pharmaceutical Co., Ltd., Suita, Osaka, Japan. morino@seirogan.co.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Morino
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koizumi
authors.forename: Takanori
authors.initials: T
authors.lastname: Miura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Fukuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibata
mesh_terms: D017927:Calicivirus, Feline / Q000187:drug effects*; D017606:Chlorine Compounds / Q000494:pharmacology*; D005740:Gases; D005782:Gels; D029322:Norovirus / Q000187:drug effects; D010087:Oxides / Q000494:pharmacology*; D038301:Virus Inactivation
chemical_list: D017606:Chlorine Compounds; D005740:Gases; D005782:Gels; D010087:Oxides; C025109:chlorine dioxide