title: Sedative effects of inhaled benzylacetone and structural features contributing to its activity.
abstract: Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure-activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity.
authors.affiliation: Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University.
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Sachiko
authors.initials: S
authors.lastname: Isomori
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Yamashita
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000280:Administration, Inhalation; D000818:Animals; D006993:Hypnotics and Sedatives / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship
chemical_list: D006993:Hypnotics and Sedatives; C531285:benzyl acetone; D000096:Acetone