title: Pulmonary tumor thrombotic microangiopathy with circulatory failure treated with imatinib.
abstract: Pulmonary tumor thrombotic microangiopathy is a lethal, yet difficult to diagnose, complication of gastrointestinal carcinoma. Even if properly diagnosed, there is no treatment, especially after a circulatory collapse. We herein report a case of pulmonary tumor thrombotic microangiopathy with circulatory failure due to pulmonary hypertension. The patient was temporarily successfully treated with imatinib, an inhibitor of the platelet-derived growth factor receptor. Pulmonary hypertension was dramatically ameliorated and the patient was able to be weaned from percutaneous cardiopulmonary support within 20 days of treatment. Imatinib may be effective for ameliorating pulmonary hypertension that is caused by pulmonary tumor thrombotic microangiopathy.
authors.affiliation: Department of Clinical Science, National Hospital Organization Okayama Medical Center, Japan. aiko-oky@umin.ac.jp
authors.forename: Aiko
authors.initials: A
authors.lastname: Ogawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamadori
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsubara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000187:drug effects* / Q000473:pathology*; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D057049:Thrombotic Microangiopathies / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate