title: Digital breast tomosynthesis versus full-field digital mammography: comparison of the accuracy of lesion measurement and characterization using specimens.
abstract: BACKGROUND
  Digital breast tomosynthesis (DBT) is one of the new techniques being developed to overcome the inherent limitations of mammography caused by superimposed structures in a 2D projection.
  
  
  OBJECTIVE
  To compare the diagnostic performances of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) for lesion characterization and size measurement using breast specimens.
  
  
  METHODS
  Out of 156 women scheduled for surgery, we included in our study 114 women, each of whom had a single, breast lesion. Three breast radiologists independently evaluated the DBT and FFDM performance regarding the breast specimens obtained during surgery. Each reader measured the lesion size, and then categorized the probability of malignancy using the American College of Radiology Breast Imaging Reporting and Data system (BI-RADS). After both reading sessions, the readers selected the preferred modality of either FFDM or DBT in lesion characterization. We also analyzed the radiologists' evaluation performance in patients with dense versus fatty breasts when using DBT and FFDM.
  
  
  RESULTS
  The imaging findings of 84 cancers and 30 benign lesions, all of which had been pathologically proven, were reviewed. The size evaluation determined by DBT was more accurately correlated with that found by pathology (P = 0.001 for fatty breasts and <0.001 for dense breasts) than that determined by FFDM. The correlation coefficients of DBT and FFDM to the pathologically determined lesion size were 0.90 and 0.89, respectively (P < 0.001). Compared with the pathologically determined lesion size, the size determined by both imaging modalities was overestimated. Overall, assessment of the probability of malignancy by DBT and FFDM did not differ significantly (P = 0.07); however, in dense breast, DBT was more strongly correlated with the pathology determination than FFDM (P = 0.03).
  
  
  CONCLUSIONS
  DBT may be superior to FFDM for determining the preoperative size measurement of breast lesions irregardless of their parenchymal density. Particularly in dense breasts, DBT was more useful for differentiating the lesion malignancy rate.
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Nieun
authors.initials: N
authors.lastname: Seo
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea hhkim@amc.seoul.kr.
authors.forename: Hak Hee
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Shin
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Cha
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Hyunji
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Radiology, Hallym University Sacred Heart Hospital, Geonggi-do, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Moon
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Gyungyub
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Sei-Hyun
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Byung Ho
authors.initials: BH
authors.lastname: Son
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods* / Q000592:standards; D008327:Mammography / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D011856:Radiographic Image Enhancement / Q000379:methods* / Q000592:standards; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results
keywords: Digital breast tomosynthesis; diagnostic performance; digital mammography; specimen