title: Mosquito repellents based on a natural chromene analogue with longer duration of action than N,N-diethyl-meta-toluamide (DEET).
abstract: Mosquito repellents play a major role in reducing bites and therefore mitigating transmission of mosquito-borne diseases. There is concern by some about the reported neurotoxic effects of the popular repellent DEET. Also, a product with longer effective activity after application is needed. This paper describes the synthesis and repellent activity of (2,2 dimethyl-2H-chromen-5-yl)methanol, a derivative of chromene amide that is a compound from the plant Amyris texana . This compound is more potent and provides longer duration of protection than DEET against Aedes aegypti (L.), the primary vector that transmits pathogens causing yellow and dengue fevers in humans.
authors.affiliation: USDA-ARS , Natural Products Utilization Research Unit, P.O. Box 8048, University, Mississippi 38677, United States.
authors.forename: Kumudini M
authors.initials: KM
authors.lastname: Meepagala
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Bernier
authors.forename: Charles
authors.initials: C
authors.lastname: Burandt
authors.forename: Stephen O
authors.initials: SO
authors.lastname: Duke
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D000852:Anopheles / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D003671:DEET / Q000494:pharmacology; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000517:prevention & control*; D007302:Insect Repellents / Q000138:chemical synthesis / Q000494:pharmacology*; D007700:Kinetics; D009994:Osmolar Concentration
chemical_list: C000589471:2,2 dimethyl-2H-chromen-5-yl)methanol; D001578:Benzopyrans; D007302:Insect Repellents; D003671:DEET