title: [Retrospective analysis of predicting biochemical recurrence after initial radical prostatectomy].
abstract: We evaluated clinical outcomes of radical prostatectomy in 244 patients who had undergone radical prostatectomy as initial treatment from January 2000 to December 2011, and were followed up for more than 6 months. Biochemical recurrence after prostatectomy was defined as prostate-specific antigen (PSA) level of at least 0. 2 ng/ml. We evaluated potential risk factors for significant associations with biochemical recurrence. Median follow-up period after prostatectomy was 49 months (range, 6-144). Of the total, 192, 31, and 20 patients were at pathological stage pT2, pT3a, and pT3b, respectively. In 83 patients with the positive surgical margin, apexes were mostly in the positive area. Of the 68 patients with PSA recurrence, PSA non-relapse rate was 66.6% for 5 years. Multivariate analysis was performed for seminal vesicle invasion, PSA nadir, surgical margins, and Gleason score. Thirty-two patients with PSA recurrence underwent salvage radiotherapy, and the biochemical recurrence rate at 5 years was 73.8%. The group in which the PSA level before salvage radiotherapy was ＜0.5 ng/ml had a low rate of biochemical recurrence. We must consider the recurrence of poorly differentiated or non-confined cancer after radical prostatectomy. These results suggest that early use of salvage radiotherapy is effective for patients with biochemical recurrence after radical prostatectomy.
authors.affiliation: The Department of Urology, Yokohama Municipal Citizen's Hospital, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Namura
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Onuki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kouno
authors.forename: Hanako
authors.initials: H
authors.lastname: Ishigaki
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Kato
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tajiri
authors.forename: Takuto
authors.initials: T
authors.lastname: Sawada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fujikawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Ota
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Moriyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Masaoki
authors.initials: M
authors.lastname: Harada
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D016879:Salvage Therapy
chemical_list: D017430:Prostate-Specific Antigen