title: Clinical nanomedicine: a solution to the chemotherapy conundrum in pediatric leukemia therapy.
abstract: Although chemotherapy-based treatment of leukemia has tremendously improved survival rates in children, induction of treatment-related side effects is a major concern in clinical oncology. The development of nanotechnology-based drug delivery techniques to target clinically approved anticancer agents specifically to leukemic cells should diminish toxic side effects. This review aims to address the rational design of nanotherapeutics in treating hematologic malignancies with a focus on acute lymphoblastic leukemia (ALL)--the most prominent form of pediatric cancer.
authors.affiliation: 1] Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, USA [2] Nemours Center for Childhood Cancer Research, A.I. duPont Hospital for Children, Wilmington, Delaware, USA [3] Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA.
authors.forename: V
authors.initials: V
authors.lastname: Krishnan
authors.affiliation: 1] Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, USA [2] Nemours Center for Childhood Cancer Research, A.I. duPont Hospital for Children, Wilmington, Delaware, USA [3] Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA [4] Department of Biological Sciences, Center for Translational Cancer Research, University of Delaware, Newark, Delaware, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Rajasekaran
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004337:Drug Carriers / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D050997:Nanomedicine / Q000379:methods*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers