title: Factors associated with blood transfusion in donor hepatectomy: results from 2344 donors at a large single center.
abstract: BACKGROUND
  The safety of healthy living donors undergoing hepatic resection for living-donor liver transplantation is of paramount concern. Although blood transfusions have been associated with morbidity and mortality after hepatectomy, there is limited information about the risk factors associated with blood transfusion in living liver donors.
  
  
  METHODS
  We retrospectively analyzed 2344 donors who underwent a hepatectomy for living-donor liver transplantation. Logistic regression analysis was performed to determine blood transfusion predictors in living-donor hepatectomy.
  
  
  RESULTS
  Of these donors, 48 (2.0%) and 97 (4.1%) were transfused with packed red blood cell (PRBC) and fresh-frozen plasma (FFP), respectively. The amount of PRBC and FFP administered to donors transfused with blood products were 1.9±0.8 and 3.7±2.5 units, respectively. In multivariate logistic regression analysis, a low preoperative hemoglobin level was found to be an independent predictor of PRBC transfusion in donor hepatectomy (odds ratio=0.585; 95% confidence interval=0.451-0.758; P<0.001). A high graft-to-donor weight ratio predicted an FFP transfusion in donor hepatectomy (odds ratio=2.997; 95% confidence interval=1.226-7.327; P=0.016).
  
  
  CONCLUSIONS
  These results indicate that, in donor hepatectomy, the preoperative hemoglobin value and graft-to-donor weight ratio can provide useful information on the probability of PRBC and FFP transfusion, respectively.
authors.affiliation: 1 Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2 Department of Occupational and Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Korea. 3 Address correspondence to: Young-Kug Kim, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2 dong, Songpa-gu, Seoul, 138-736, Republic of Korea.
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Choi
authors.forename: Seong-Sik
authors.initials: SS
authors.lastname: Cho
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: In-Gu
authors.initials: IG
authors.lastname: Jun
authors.forename: Gyu-Sam
authors.initials: GS
authors.lastname: Hwang
authors.forename: Young-Kug
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001803:Blood Transfusion / Q000401:mortality; D015992:Body Mass Index; D001835:Body Weight; D016009:Chi-Square Distribution; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006498:Hepatectomy / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D019520:Living Donors; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D009929:Organ Size; D010949:Plasma; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins