title: [Contrast-enhanced ultrasonography for detecting testicular perfusion in acute testis contusion in rabbits].
abstract: OBJECTIVE
  To evaluate contrast-enhanced ultrasonography (CEUS) in detecting testicular perfusion in acute testis contusion.
  
  
  METHODS
  We established the model of testis contusion in 11 healthy male New Zealand rabbits by randomly hitting one side of the scrotum under general anesthesia. We examined the bilateral scrotums of all the animals before, immediately after and at 2, 4 and 6 hours after modeling by color Doppler flow imaging (CDFI) and CEUS, and analyzed the time-intensity curve (TIC), arriving time (AT), time to peak intensity (TTP), peak intensity (PI), half time of descending peak intensity (HT) and area under the curve (AUC) in the healthy and injured testis, respectively.
  
  
  RESULTS
  CEUS exhibited a higher sensitivity in detecting tissue perfusion than CDFI. The mode of contrast agent perfusion in testicular contusion was fast in and slow out. There were no evident differences between the contused and the healthy testis in AT, TTP and PI before modeling. The contused testis showed significantly earlier AT and TTP, higher PI and larger AUC (P < 0.05) than the healthy one at different time points after modeling, but no statistically significant difference was found in HT (P > 0.05).
  
  
  CONCLUSIONS
  Accurate parameters of testicular perfusion in acute testis contusion can be quantitatively obtained by CEUS, which are of important value for the diagnosis of testis contusion.
authors.affiliation: Department of Ultrasound, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
authors.forename: Ya-Xi
authors.initials: YX
authors.lastname: Zhao
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Huang
authors.forename: Yan-Wu
authors.initials: YW
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Cao
authors.forename: Ping-Yu
authors.initials: PY
authors.lastname: Zhu
authors.forename: Bing-Lei
authors.initials: BL
authors.lastname: Jiang
authors.forename: Peng
authors.initials: P
authors.lastname: Gu
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
mesh_terms: D000818:Animals; D003287:Contrast Media; D003288:Contusions / Q000000981:diagnostic imaging*; D008297:Male; D011817:Rabbits; D013737:Testis / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000293:injuries; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media