title: Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia.
abstract: Treatment of chronic monocytic leukemia (CMoL) in dogs has traditionally consisted of hydroxyurea. The use of tyrosine kinase inhibitors has been proposed as a treatment option for dogs with CMoL but has never been reported. We report a case of CMoL in a young dog that achieved clinical remission with treatment with the tyrosine kinase inhibitor toceranib and prednisone.
authors.affiliation: Departments of aSmall Animal Clinical Sciences bPhysiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida cDepartment of Molecular Biomedical Sciences dDepartment of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh eCancer Genetics Program, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
authors.forename: Mayrim L
authors.initials: ML
authors.lastname: Pérez
authors.forename: Sarah
authors.initials: S
authors.lastname: Culver
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Owen
authors.forename: Mark
authors.initials: M
authors.lastname: Dunbar
authors.forename: Kelvin
authors.initials: K
authors.lastname: Kow
authors.forename: Matthew
authors.initials: M
authors.lastname: Breen
authors.forename: Rowan J
authors.initials: RJ
authors.lastname: Milner
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy* / Q000235:genetics; D004285:Dogs; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011758:Pyrroles / Q000008:administration & dosage / Q000627:therapeutic use; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D007211:Indoles; D011758:Pyrroles; C464577:toceranib phosphate; D016044:Fusion Proteins, bcr-abl; D011241:Prednisone