title: Profiling of microbial-derived phenolic metabolites in human feces after moderate red wine intake.
abstract: A controlled and randomized trial study involving 41 healthy volunteers (33 intervention and 8 control subjects) was performed in order to establish changes in the microbial-derived phenolic metabolite profile of feces after moderate consumption of red wine (250 mL/day, 4 weeks). Out of the 35 phenolic metabolites identified, 10 compounds (mainly benzoic and 4-hydroxyvaleric acids) showed statistically significant increases (P < 0.05) after the wine intake. Also, the total phenolic metabolites content was significantly (P < 0.05) higher in the samples after the wine intake (625 ± 380 μg/g feces) in comparison to the samples before (358 ± 270 μg/g feces), and a tentative distribution of the volunteers into three groups could be established: <500, 500-1000, and >1000 μg/g feces. These results suggest that a different gut microbial capacity to metabolize wine polyphenols exists among the human population, as observed for polyphenols from other sources.
authors.affiliation: Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, CEI UAM+CSIC , c/Nicolás Cabrera 9, 28049 Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Muñoz-González
authors.forename: Ana
authors.initials: A
authors.lastname: Jiménez-Girón
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Martín-Álvarez
authors.forename: Begoña
authors.initials: B
authors.lastname: Bartolomé
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Moreno-Arribas
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D019817:Benzoic Acid / Q000032:analysis / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D006090:Gram-Negative Bacteria / Q000254:growth & development / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000032:analysis* / Q000378:metabolism; D015203:Reproducibility of Results; D013030:Spain; D015854:Up-Regulation; D014631:Valerates / Q000032:analysis / Q000378:metabolism; D014920:Wine / Q000032:analysis* / Q000382:microbiology; D015003:Yeasts / Q000254:growth & development / Q000378:metabolism; D055815:Young Adult
chemical_list: D010636:Phenols; D014631:Valerates; C469548:4-hydroxyvaleric acid; D019817:Benzoic Acid