title: targetHub: a programmable interface for miRNA-gene interactions.
abstract: BACKGROUND
  With the expansion of high-throughput technologies, understanding different kinds of genome-level data is a common task. MicroRNA (miRNA) is increasingly profiled using high-throughput technologies (microarrays or next-generation sequencing). The downstream analysis of miRNA targets can be difficult. Although there are many databases and algorithms to predict miRNA targets, there are few tools to integrate miRNA-gene interaction data into high-throughput genomic analyses.
  
  
  RESULTS
  We present targetHub, a CouchDB database of miRNA-gene interactions. TargetHub provides a programmer-friendly interface to access miRNA targets. The Web site provides RESTful access to miRNA-gene interactions with an assortment of gene and miRNA identifiers. It can be a useful tool to integrate miRNA target interaction data directly into high-throughput bioinformatics analyses.
  
  
  BACKGROUND
  TargetHub is available on the web at http://app1.bioinformatics.mdanderson.org/tarhub/_design/basic/index.html.
authors.affiliation: Department of Bioinformatics and Computational Biology, Department of Gynecologic Oncology and Reproductive Medicine and Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Ganiraju
authors.initials: G
authors.lastname: Manyam
authors.forename: Cristina
authors.initials: C
authors.lastname: Ivan
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Coombes
mesh_terms: D000465:Algorithms; D053263:Gene Regulatory Networks; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000235:genetics*; D012984:Software
chemical_list: D035683:MicroRNAs