title: Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout.
abstract: Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1β, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 ± 86.7, 49.7 ± 107.7, 2.1 ± 7.0, and 152.6 ± 155.7 pg/mL, respectively. The mean level and the frequency of high levels (≥125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides.
authors.affiliation: Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
authors.forename: Chang-Nam
authors.initials: CN
authors.lastname: Son
authors.forename: So-Young
authors.initials: SY
authors.lastname: Bang
authors.forename: Ji Hae
authors.initials: JH
authors.lastname: Kim
authors.forename: Chan-Bum
authors.initials: CB
authors.lastname: Choi
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Jae-Bum
authors.initials: JB
authors.lastname: Jun
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D020170:Caspase 1 / Q000032:analysis*; D005260:Female; D006073:Gout / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020382:Interleukin-18 / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D025242:Spondylarthropathies / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D013582:Synovial Fluid / Q000201:enzymology* / Q000378:metabolism; D014527:Uric Acid / Q000032:analysis
chemical_list: D020382:Interleukin-18; D053583:Interleukin-1beta; D014527:Uric Acid; D020170:Caspase 1
keywords: Caspase-1; Gout; Spondyloarthropathies; Synovial Fluid