title: [The influenza viruses and their surface proteins impact on the metabolism of human blood vessel endothelium cells].
abstract: The modern influenza virus subtypes H3N2, H5N1, and H1N1 reduced the metabolism of the endothelial cells within the range from 20% to 60% (compared with control). The degree of the activity of the dehydrogenase reduction depended on the dose of virus and time of virus reproduction. HA and NA also actively reduced the metabolism of the cells ranging from 5% to 60%, depending on the concentration of the proteins and time of their impact on cells. Neuraminidase was more active than hemagglutinin in the MTT test (at concentration 50 microg protein/ml).
authors.forename: A A
authors.initials: AA
authors.lastname: Azarenok
authors.forename: E M
authors.initials: EM
authors.lastname: Eropkina
authors.forename: A R
authors.initials: AR
authors.lastname: Prochukhanova
authors.forename: A A
authors.initials: AA
authors.lastname: Shaldzhian
authors.forename: N M
authors.initials: NM
authors.lastname: Kozlova
authors.forename: K N
authors.initials: KN
authors.lastname: Kozeletskaia
authors.forename: I N
authors.initials: IN
authors.lastname: Zhilinskaia
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000254:growth & development* / Q000472:pathogenicity; D053122:Influenza A Virus, H3N2 Subtype / Q000254:growth & development* / Q000472:pathogenicity; D053124:Influenza A Virus, H5N1 Subtype / Q000254:growth & development* / Q000472:pathogenicity; D009439:Neuraminidase / Q000302:isolation & purification / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D015415:Biomarkers; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D013778:Tetrazolium Salts; D013844:Thiazoles; D010088:Oxidoreductases; D009439:Neuraminidase; C022616:thiazolyl blue