title: Marrow mesenchymal stromal cells reduce methicillin-resistant Staphylococcus aureus infection in rat models.
abstract: OBJECTIVE
  Staphylococci account for a large proportion of hospital-acquired infections, especially among patients with indwelling devices. These infections are often caused by biofilm-producing strains, which are difficult to eradicate and may eventually cause bacteremia and metastatic infections. Recent evidence suggests that mesenchymal stem cells can enhance bacterial clearance in vivo.
  
  
  METHODS
  In this study, a rat model with carboxymethyl cellulose pouch infection was used to analyze the efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) against the methicillin-resistant Staphylococcus aureus.
  
  
  RESULTS
  The results showed that the administration of BMSCs effectively reduced the number of bacterial colonies and the expression of many cytokines and chemokines (such as interleukin [IL]-6, IL-1β, IL-10 and CCL5). Unlike the fibroblast control groups, the pouch tissues from the BMSC-treated rats showed the formation of granulations, suggesting that the healing of the wound was in progress.
  
  
  CONCLUSIONS
  The results indicate that the treatment of BMSCs can reduce methicillin-resistant S aureus infection in vivo, thereby reducing the inflammatory response.
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China.
authors.forename: Songyi
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China.
authors.forename: Na
authors.initials: N
authors.lastname: Guo
authors.affiliation: College of Animal Science and Veterinary Medicine, Jilin University, Changchun, China.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China.
authors.forename: Suxia
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Bu
authors.affiliation: Department of Food Quality and Safety, College of Agriculture, Jilin University, Changchun, China. Electronic address: yehq@jlu.edu.cn.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Ye
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D002266:Carboxymethylcellulose Sodium / Q000633:toxicity; D064987:Cell- and Tissue-Based Therapy; D004195:Disease Models, Animal; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D051381:Rats; D013203:Staphylococcal Infections / Q000139:chemically induced / Q000382:microbiology / Q000473:pathology / Q000628:therapy*
chemical_list: D002266:Carboxymethylcellulose Sodium
keywords: mesenchymal stromal cells; methicillin-resistant Staphylococcus aureus; rat models