title: The genome of the hydatid tapeworm Echinococcus granulosus.
abstract: Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCavβ1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.
authors.affiliation: 1] Shanghai-Ministry of Science and Technology Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China. [2].
authors.forename: Huajun
authors.initials: H
authors.lastname: Zheng
authors.forename: Wenbao
authors.initials: W
authors.lastname: Zhang
authors.forename: Liang
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authors.lastname: Zhang
authors.forename: Zhuangzhi
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authors.lastname: Zhang
authors.forename: Jun
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authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Yongqiang
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authors.lastname: Zhu
authors.forename: Yuezhu
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authors.lastname: Wang
authors.forename: Yin
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authors.lastname: Huang
authors.forename: Jing
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authors.forename: Hui
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authors.lastname: Kang
authors.forename: Jie
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authors.lastname: Chen
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Aojun
authors.initials: A
authors.lastname: Chen
authors.forename: Shuting
authors.initials: S
authors.lastname: Yu
authors.forename: Zhengchao
authors.initials: Z
authors.lastname: Gao
authors.forename: Lei
authors.initials: L
authors.lastname: Jin
authors.forename: Wenyi
authors.initials: W
authors.lastname: Gu
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Baoxin
authors.initials: B
authors.lastname: Shi
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.forename: Renyong
authors.initials: R
authors.lastname: Lin
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Jones
authors.forename: Brona
authors.initials: B
authors.lastname: Brejova
authors.forename: Tomas
authors.initials: T
authors.lastname: Vinar
authors.forename: Guoping
authors.initials: G
authors.lastname: Zhao
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Shengyue
authors.initials: S
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D048209:Echinococcus granulosus / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D049751:Genome, Helminth; D057131:Immune Evasion; D008969:Molecular Sequence Data; D010802:Phylogeny; D012098:Reproduction; D017386:Sequence Homology, Amino Acid