title: Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine.
abstract: The past few years have seen unexpected new developments in direct cardiomyocyte reprogramming. Direct cardiomyocyte reprogramming potentially offers an entirely novel approach to cardiovascular regenerative medicine by converting cardiac fibroblasts into functional cardiomyocytes in situ. There is much to be learned, however, about the mechanisms of direct reprogramming in order that the process can be made more efficient. Early efforts have suggested that this new technology can be technically challenging. Moreover, new methods of inducing heart reprogramming will need to be developed before this approach can be translated to the bedside. Despite this, direct cardiomyocyte reprogramming may lead to new therapeutic options for sufferers of heart disease.
authors.affiliation: Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114.
authors.forename: B Alexander
authors.initials: BA
authors.lastname: Yi
authors.forename: Christine L
authors.initials: CL
authors.lastname: Mummery
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Chien
mesh_terms: D000818:Animals; D054338:Cell Transdifferentiation / Q000502:physiology*; D002478:Cells, Cultured; D065150:Cellular Reprogramming / Q000502:physiology; D006801:Humans; D051379:Mice; D023421:Models, Animal; D032386:Myoblasts, Cardiac / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D012038:Regeneration / Q000502:physiology*