title: Platelet-rich plasma and chronic wounds: remaining fibronectin may influence matrix remodeling and regeneration success.
abstract: BACKGROUND
  Platelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules.
  
  
  OBJECTIVE
  We hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich plasma preparations.
  
  
  METHODS
  Recent reports were analyzed and presented as direct evidences of this hypotheses.
  
  
  RESULTS
  Fibronectin may directly influence the extracellular matrix remodeling during wound repair. This effect is probably through matrix metalloproteinase expression, thus exerting an extra effect on chronic wound regeneration.
  
  
  CONCLUSIONS
  Physicians should be well aware of the possible fibronectin-induced effects in their future endeavors with PRP in chronic wound treatment.
authors.affiliation: Blood Transfusion Center, Cell Engineering Laboratory, Botucatu Medical School, Universidade Estadual Paulista-UNESP, Botucatu, SP, Brazil; Department of Morphology, Extracellular Matrix Laboratory, Botucatu Biosciences Institute, Universidade Estadual Paulista-UNESP, Botucatu, SP, Brazil. Electronic address: moroz@ibb.unesp.br.
authors.forename: Andrei
authors.initials: A
authors.lastname: Moroz
authors.forename: Elenice
authors.initials: E
authors.lastname: Deffune
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D053657:Platelet-Rich Plasma / Q000378:metabolism*; D012038:Regeneration; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D005353:Fibronectins; D020782:Matrix Metalloproteinases
keywords: MMP; PRP; chronic wounds; extracellular matrix; fibronectin; platelet-rich plasma; wound regeneration