title: A new deferiprone controlled release system obtained by ultrasound-assisted compression.
abstract: OBJECTIVE
  This study implements the design of an innovative dosage form using ultrasound-assisted compression of thermoplastic polymers and the development of controlled release tablets for the oral administration of deferiprone in two doses per day.
  
  
  METHODS
  Binary matrix tablets containing deferiprone and thermoplastic polymers have been prepared using an ultrasound-assisted tableting machine. Scanning electron microscopy has been employed to determine a sintering phenomenon of the excipients. Water uptake and drug release studies have been carried out to evaluate the ability of the polymers to control the drug release.
  
  
  RESULTS
  SEM micrographs showed that some polymers underwent the sintering process and the in vitro dissolution test showed good fit of the release data from these tablets to the zero-order kinetic model.
  
  
  CONCLUSIONS
  Carbopol 974P and 971P have been selected as matrix forming polymers for the final formulation. The polymer percolation threshold has been exceeded with 15% w/w of polymer. Therefore, sustained release tablets have been developed with only 15% of excipient. This implies that matrix tablets containing 750 mg of API, intended for two administrations a day, can be obtained with a similar weight to those existing in the market containing 500 mg of API for three administrations a day.
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, University of Seville , Sevilla , Spain .
authors.forename: Angela
authors.initials: A
authors.lastname: Aguilar-De-Leyva
authors.forename: Tamara
authors.initials: T
authors.lastname: Gonçalves-Araujo
authors.forename: Verónica
authors.initials: V
authors.lastname: Daza
authors.forename: Isidoro
authors.initials: I
authors.lastname: Caraballo
mesh_terms: D000077543:Deferiprone; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004304:Dosage Forms; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D007700:Kinetics; D011108:Polymers / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry; D014465:Ultrasonics / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005079:Excipients; D011108:Polymers; D011728:Pyridones; D013607:Tablets; D014867:Water; D000077543:Deferiprone