title: Top 10 clinical research developments in antiphospholipid syndrome.
abstract: Persistently positive antiphospholipid antibodies (aPL) with thrombosis and/or pregnancy morbidity are a characteristic of antiphospholipid syndrome (APS). Although many challenges and controversies exist regarding APS diagnosis and management, there has been significant progress in APS clinical research in parallel with increased understanding of the pathogenesis. The purpose of this review is to discuss the "top ten" recent clinical developments in APS, including the magnitude of the problem, standardization of aPL tests, predictors of clinical events, diagnostic algorithms, new clinical research collaboration, and potential future treatments, e.g., new anticoagulants and immunosuppressive agents.
authors.affiliation: Department of Rheumatology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Medha
authors.initials: M
authors.lastname: Barbhaiya
authors.forename: Doruk
authors.initials: D
authors.lastname: Erkan
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D035843:Biomedical Research / Q000639:trends*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D013927:Thrombosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D007166:Immunosuppressive Agents