title: Chemoselective hydrosilylation of hydroxyketones.
abstract: A chemoselective method for the hydrosilylation of ketones has been developed, using the combination of triphenylsilane and a catalyst prepared from Ni(COD)2and the simpleN-heterocyclic carbene IMes. The most notable feature of this method is that free hydroxyls are largely unaffected, thus providing a simple one-step procedure for the conversion of hydroxyketones to mono-protected diols, wherein the protecting group is exclusively installed on the ketone-derived hydroxyl. The process is typically high yielding with both simple ketones and more complex hydroxyketone substrates.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, United States.
authors.forename: Marta L
authors.initials: ML
authors.lastname: Lage
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Bader
authors.forename: Kanicha
authors.initials: K
authors.lastname: Sa-Ei
authors.forename: John
authors.initials: J
authors.lastname: Montgomery
keywords: Chemoselective; Dehydrogenative silylation; Hydrosilylation; Nickel; Site-selective