title: [The effect of 5-hydroxyadamantan-2-one on morphological status of rats' brain tissues in local permanent ischemia conditions].
abstract: The effect of 5-hydroxyadamantane-2-one was studied on morphological state of brain tissue of rats after the occlusion of left middle cerebral artery. It was shown that intraperitoneal administration of 5-hydroxyadamantane-2-on at dose 100mg/kg, in 30 minutes after occlusion and once daily for the following 6 and 12 days leads to significant regenerative processes in brain tissue. These processes were more profound after the 12-day treatment with 5-hydroxyadamanta-ne-2-one.
authors.forename: N R
authors.initials: NR
authors.lastname: Mirzoian
authors.forename: N G
authors.initials: NG
authors.lastname: Khostikian
authors.forename: V S
authors.initials: VS
authors.lastname: Meliksetian
authors.forename: K B
authors.initials: KB
authors.lastname: Alikhanian
authors.forename: A G
authors.initials: AG
authors.lastname: Stepanian
authors.forename: A A
authors.initials: AA
authors.lastname: Akopian
authors.forename: A M
authors.initials: AM
authors.lastname: Kukhtarova
authors.forename: N A
authors.initials: NA
authors.lastname: Bagdasarian
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000503:physiopathology; D004334:Drug Administration Schedule; D018755:GABA Agonists / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats
chemical_list: D018755:GABA Agonists; D020011:Protective Agents; D000218:Adamantane