title: Inflamed psoriatic plaques: drug toxicity or disease exacerbation?
abstract: We are presenting a case of Methotrexate treated stable plaque psoriasis, in whom inflamed psoriatic plaques of drug toxicity were misdiagnosed as disease exacerbation. Erosive psoriatic plaques were present in the absence of biochemical or hematological derangements. Ulceration of psoriatic plaques in the presence of disturbed hematological profile is well described as a harbinger of methotrexate toxicity, but this kind of erosions in the absence of any systemic involvement is the first report of its kind.
authors.affiliation: Department of Dermatology and Venereology, Pt BDS PGIMS, Rohtak, Haryana, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Jindal
authors.forename: Kshama
authors.initials: K
authors.lastname: Arora
authors.forename: Pooja
authors.initials: P
authors.lastname: Jindal
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Jain
authors.forename: Sangita
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000328:Adult; D003879:Dermatologic Agents / Q000009:adverse effects*; D003967:Diarrhea; D018450:Disease Progression; D006261:Headache; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*; D012883:Skin Ulcer / Q000209:etiology*; D014786:Vision Disorders
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate
keywords: Methotrexate toxicity; myelosuppression; psoriasis exacerbation