title: The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function.
abstract: BACKGROUND
  Obesity is associated with impaired microvascular endothelial function. We aimed to determine the effects of orlistat and sibutramine treatment on microvascular endothelial function, anthropometric and lipid profile, blood pressure (BP), and heart rate (HR).
  
  
  METHODS
  76 subjects were recruited and randomized to receive orlistat 120 mg three times daily or sibutramine 10 mg daily for 9 months. Baseline weight, BMI, BP, HR and lipid profile were taken. Microvascular endothelial function was assessed using laser Doppler fluximetry and iontophoresis process. Maximum change (max), percent change (% change) and peak flux (peak) in perfusion to acetylcholine (ACh) and sodium nitroprusside (SNP) iontophoresis were used to quantify endothelium dependent and independent vasodilatations.
  
  
  RESULTS
  24 subjects in both groups completed the trial. After treatment, weight and BMI were decreased for both groups. AChmax, ACh % change and ACh peak were increased in orlistat-treated group but no difference was observed for sibutramine-treated group. BP and total cholesterol (TC) were reduced for orlistat-treated group. HR was reduced for orlistat-treated group but was increased in sibutramine-treated group.
  
  
  CONCLUSIONS
  9 months treatment with orlistat significantly improved microvascular endothelial function. This was associated with reductions in weight, BMI, BP, HR, TC and low density lipoprotein cholesterol. No effect was seen in microvascular endothelial function with sibutramine.
authors.affiliation: Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Belqes Abdullah Mohammad
authors.initials: BA
authors.lastname: Al-Tahami
authors.affiliation: Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Ab Aziz Al-Safi
authors.initials: AA
authors.lastname: Ismail
authors.affiliation: School of Health Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Yvonne Tee Get
authors.initials: YT
authors.lastname: Bee
authors.affiliation: Universiti Sains Malaysia Hospital, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Siti Azima
authors.initials: SA
authors.lastname: Awang
authors.affiliation: Universiti Sains Malaysia Hospital, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Wan Rimei
authors.initials: WR
authors.lastname: Salha Wan Abdul Rani
authors.affiliation: Central Research Laboratory, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Zulkefli
authors.initials: Z
authors.lastname: Sanip
authors.affiliation: Pharmacology Vascular Laboratory, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
authors.forename: Aida Hanum Ghulam
authors.initials: AH
authors.lastname: Rasool
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000886:Anthropometry; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D003503:Cyclobutanes / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D055806:Microvessels / Q000187:drug effects; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D003503:Cyclobutanes; D007783:Lactones; D000077403:Orlistat; D002784:Cholesterol; C058254:sibutramine
keywords: Microvascular endothelial function; obesity; orlistat; sibutramine