title: Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma.
abstract: Visfatin, a novel adipocytokine, is related with chronic inflammatory diseases, especially those characterized by T helper (Th)1-type immune responses. In this study, we examined serum visfatin levels in patients with atopic dermatitis (AD) or cutaneous T-cell lymphoma (CTCL), both of which are Th2-dominant diseases. Serum visfatin levels in patients with AD or advanced stage CTCL were significantly elevated compared to healthy controls. In CTCL patients, serum visfatin levels significantly decreased after treatment. Serum visfatin levels correlated with eosinophil counts in AD patients, whereas they correlated with the visual analogue scale itch scores and serum C-C motif ligand (CCL) 11 and CCL26 levels in CTCL patients. Visfatin expression by adipose tissue in lesional skin of AD and advanced stage CTCL was enhanced compared to that of healthy controls. These results suggest that visfatin may also be important in the development of Th2-dominant diseases as well as in Th1-type diseases.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Hiraku
authors.initials: H
authors.lastname: Suga
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyagaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Sohshi
authors.initials: S
authors.lastname: Morimura
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kai
authors.forename: Shinji
authors.initials: S
authors.lastname: Kagami
authors.forename: Hanako
authors.initials: H
authors.lastname: Ohmatsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujita
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tada
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kadono
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D015992:Body Mass Index; D016022:Case-Control Studies; D054413:Chemokine CCL11 / Q000097:blood; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000097:blood; D016207:Cytokines / Q000097:blood*; D003876:Dermatitis, Atopic / Q000097:blood / Q000201:enzymology*; D004804:Eosinophils; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011537:Pruritus / Q000097:blood; D012720:Severity of Illness Index; D012751:Sezary Syndrome / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D055815:Young Adult
chemical_list: C515456:CCL11 protein, human; C120429:CCL26 protein, human; D054413:Chemokine CCL11; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: adipose tissue; atopic dermatitis; cutaneous T-cell lymphoma; mycosis fungoides; visfatin