title: Endoscopic repair of CSF rhinorrhea: necessity of fibrin glue.
abstract: OBJECTIVE
  The aim of this study is to compare the efficacy of cerebrospinal fluid (CSF) repair with and without fibrin glue in pediatric patients with CSF rhinorrhea treated endoscopically.
  
  
  METHODS
  This was a retrospective study carried out in the Departments of Otolaryngology and Neurosurgery at a tertiary care center between December 2005 and July 2010.
  
  
  RESULTS
  The 27 patients with CSF rhinorrhea included in the study were divided into Group A: 13 patients who underwent endoscopic endonasal CSF repair using fibrin glue (Tisseel, Baxter, Vienna, Austria) by an endoscopic rhinologist and Group B: 14 patients who underwent endonasal CSF repair without fibrin glue. There was no statistically significant difference in endoscopic CSF repairs with or without fibrin glue (P = 0.48) in all the variables studied. CSF repair without fibrin glue appeared more cost saving as compared to repair with glue.
  
  
  CONCLUSIONS
  CSF repairs with and without fibrin glue are equally effective and CSF repair without fibrin is costs saving.
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Satyawati
authors.initials: S
authors.lastname: Mohindra
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mohindra
authors.forename: Karan
authors.initials: K
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D002559:Cerebrospinal Fluid Rhinorrhea / Q000601:surgery*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy / Q000379:methods*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods*; D009666:Nose / Q000601:surgery; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive