title: Neurologic complications and sequellae of infectious diseases in Uganda and Kenya: Analysis of 288 cases from two rural hospitals.
abstract: OBJECTIVE
  Many infections occurring in area of Sub-Saharan Africa are associated with more or less serious neurologic symptoms or complications. The aim of this study was to assess the incidence of selected infectious diseases in the equatorial part of Uganda and Kenya and to monitor potential neurological complications of these infections.
  
  
  METHODS
  The study was performed for May - August 2008. Patients suffering from cerebral malaria, AIDS, meningitis, typhoid, tuberculosis (TB), syphilis, leprosy, and trypanosomiasis patients were enrolled. Besides of standard examination, lumbar puncture (LP) and cerebrospinal fluid (CSF) examination was performed, and the occurrence of neurological disorders and sequellae was recorded and assessed.
  
  
  RESULTS
  Altogether 288 patients with neurological manifestation were enrolled. Malaria was the most prevalent disease in this study (102 cases, 35.42%), followed by typhoid (47 cases, 16.2%) and meningitis (38 cases, 13.2%). Leprosy and trypanosomiasis were only rarely detected (2.3% and 1.4%, respectively).
  
  
  CONCLUSIONS
  In malaria and HIV hyper-endemic area of rural Uganda, cerebral malaria is the leading tropical neuroinfection. Also, meningitis is still frequent probably due to insufficient access to vaccination.
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Ivan
authors.initials: I
authors.lastname: Szabo
authors.affiliation: St. Elisabeth University College of Health and Social Sciences, Laboratory of Molecular Microbiology, Bratislava, Slovakia.
authors.forename: Nada
authors.initials: N
authors.lastname: Kulkova
authors.affiliation: St. Elisabeth University College of Health and Social Sciences, Laboratory of Molecular Microbiology, Bratislava, Slovakia.
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Sokolova
authors.affiliation: St. Elisabeth University College of Health and Social Sciences, Laboratory of Molecular Microbiology, Bratislava, Slovakia.
authors.forename: Gertruda
authors.initials: G
authors.lastname: Mikolasova
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Jozef
authors.initials: J
authors.lastname: Suvada
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Andrea
authors.initials: A
authors.lastname: Kalavska
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Silvia
authors.initials: S
authors.lastname: Dobrodenkova
authors.affiliation: St. Elisabeth University College of Health and Social Sciences, Laboratory of Molecular Microbiology, Bratislava, Slovakia.
authors.forename: Frantisek
authors.initials: F
authors.lastname: Mateicka
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Jirina
authors.initials: J
authors.lastname: Kafkova
authors.affiliation: St. Elisabeth Tropical and Doctoral Program, St. Charles Lwanga Hospital, Buikwe, Uganda.
authors.forename: Innocent
authors.initials: I
authors.lastname: Nkonwa