title: Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones.
abstract: 3-Substituted 2-quinolones are obtained via a novel, metal-free transannulation reaction of 2-substituted indoles with 2-nitroalkenes in polyphosphoric acid. The reaction can be used in conjunction with the Fisher indole synthesis offering a practical three-component heteroannulation methodology to produce 2-quinolones from arylhydrazines, 2-nitroalkenes and acetophenone.
authors.affiliation: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation. alexaks05@rambler.ru.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Aksenov
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Smirnov
authors.forename: Nicolai A
authors.initials: NA
authors.lastname: Aksenov
authors.forename: Inna V
authors.initials: IV
authors.lastname: Aksenova
authors.forename: Liliya V
authors.initials: LV
authors.lastname: Frolova
authors.forename: Alexander
authors.initials: A
authors.lastname: Kornienko
authors.forename: Igor V
authors.initials: IV
authors.lastname: Magedov
authors.forename: Michael
authors.initials: M
authors.lastname: Rubin
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D007536:Isomerism; D008670:Metals / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000475:Alkenes; D007211:Indoles; D008670:Metals; D010756:Phosphoric Acids; D011108:Polymers; D015363:Quinolones; C047269:polyphosphoric acid; C038699:acetophenone