title: Reasons driving treatment modification in Parkinson's disease: results from the cross-sectional phase of the REASON study.
abstract: OBJECTIVE
  To assess the association between clinical and socio-demographic features and anti-Parkinson drug (APD) treatment modifications in patients with PD and to describe neurologist and patient opinions regarding the need for changes in APD therapy.
  
  
  METHODS
  Subjects with PD with stable APD treatment over ≥3 months prior to baseline were enrolled and evaluated for socio-demographic data, disability, disease severity and neurologist and patient views on the need to modify APD treatment.
  
  
  RESULTS
  775 Patients were included, 51% with Hoehn and Yahr (HY) stage 1-2 (early PD) and 49% with HY stage 2.5-4 (advanced PD). Neurologists modified APD treatment in 255 patients, 97 (25%) early PD and 158 (41%; p < 0.0001) advanced PD. APD modification was strongly associated with a low educational level and UPDRS part IV score. The most common reasons behind the APD therapy changes among neurologists were presence/worsening of motor or non-motor symptoms (88% and 37% of subjects respectively). Out of 216 patients, 92% and 51% were willing to undergo APD changes to therapy because of the presence/worsening of motor or non-motor symptoms.
  
  
  CONCLUSIONS
  Neurologist decision to change APD therapy and patients reasons for dissatisfaction with it can be prevalently attributed to the presence/worsening of motor symptoms and motor fluctuations in the advanced stages. Non-motor symptoms were considered more often by patients. The patient educational level played a key role in treatment decision.
authors.affiliation: Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Università di Verona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Tinazzi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Abbruzzese
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
authors.forename: Roberto
authors.initials: R
authors.lastname: Ceravolo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fabbrini
authors.forename: Patrizia
authors.initials: P
authors.lastname: Lessi
authors.forename: Paolo
authors.initials: P
authors.lastname: Barone
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D012959:Socioeconomic Factors
chemical_list: D000978:Antiparkinson Agents
keywords: Anti-Parkinson drugs; Motor symptoms; Non-motor symptoms; Parkinson's disease