title: [Meta analysis on the immunogenicity of domestic influenza virus vaccines].
abstract: OBJECTIVE
  To evaluate the immunogenicity of domestic influenza virus vaccines.
  
  
  METHODS
  The published studies that compared the immunogenicity between domestic and imported influenza virus vaccines in Chinese population before September 2012 were collected and evaluated with meta analysis using Stata 10.0 software package.
  
  
  RESULTS
  A total of 20 studies that met inclusion criteria were included in this review. The meta analysis result showed that the positive seroconversion rate of B flu virus strain of domestic influenza virus vaccines was significantly higher than that of imported influenza virus vaccines (P=0.036, RR=1.036, 95%CI: 1.002-1.070). No significant difference in three strains' protective rate, H1N1 and H3N2 positive seroconversion rate was found between the domestic and imported influenza virus vaccines (P>0.05). Stratified analysis showed that domestic whole influenza virus vaccine had significantly higher protective rate (P=0.031, RR=1.059, 95%CI: 1.005-1.116), positive seroconversion rate (P=0.024, RR=1.040, 95%CI: 1.005-1.077) of B flu virus strain, and protective rate of H3N2 flu virus strain (P=0.019, RR=1.053, 95%CI: 1.009-1.098) than imported influenza virus vaccines.
  
  
  CONCLUSIONS
  Domestic influenza virus vaccines have desirable immunogenicity.
authors.affiliation: Songjiang District Center for Disease Control and Prevention, Shanghai, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Ren
authors.forename: Jinhua
authors.initials: J
authors.lastname: Shen
authors.forename: Wenhua
authors.initials: W
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Shikang
authors.initials: S
authors.lastname: Gu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Lu
mesh_terms: D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*
chemical_list: D007252:Influenza Vaccines