title: Bordetella bronchiseptica in a pediatric Cystic Fibrosis center.
abstract: BACKGROUND
  Bordetella bronchiseptica is a common pathogenic or colonizing organism of domestic mammals. In dogs, it causes an infectious tracheobronchitis known as Kennel Cough. Human infections are unusual and almost exclusively described in immunocompromised patients who have had contact with a known animal reservoir. It is rarely reported in Cystic Fibrosis (CF), possibly hampered by low recovery from culture and organism misidentification. We describe the incidence and characteristics of B. bronchiseptica in our CF population.
  
  
  METHODS
  A retrospective cohort study was conducted of our center's CF patient population. Patients were included if they had B. bronchiseptica isolated on one or more occasion.
  
  
  RESULTS
  Seven children with CF isolated B. bronchiseptica on 23 occasions, frequently associated with the symptoms of a pulmonary exacerbation. Four patients required hospitalization.
  
  
  CONCLUSIONS
  These results suggest that B. bronchiseptica may be more common than previously reported and may play a potential pathogenic role in CF.
authors.affiliation: Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States; Children's Respiratory and Critical Care Specialists, 2530 Chicago Avenue South, Minneapolis, MN 55404, United States. Electronic address: brady@crccs.com.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Brady
authors.affiliation: Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ackerman
authors.affiliation: Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States.
authors.forename: Mahrya
authors.initials: M
authors.lastname: Johnson
authors.affiliation: Children's Hospitals and Clinics of MN, Center for Cystic Fibrosis, 2525 Chicago Avenue South, Minneapolis, MN 55404, United States; Children's Respiratory and Critical Care Specialists, 2530 Chicago Avenue South, Minneapolis, MN 55404, United States.
authors.forename: John
authors.initials: J
authors.lastname: McNamara
mesh_terms: D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001885:Bordetella Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016950:Bordetella bronchiseptica / Q000276:immunology / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology; D004285:Dogs; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Animal; Bordetella bronchiseptica; Cystic Fibrosis; Pathogen