title: Clinical and pathological characteristics of ocular surface squamous neoplasia in an Asian population.
abstract: BACKGROUND
  In order to evaluate clinical and pathological characteristics of ocular surface squamous neoplasia (OSSN) in Asian population.
  
  
  METHODS
  Medical records were reviewed of 30 eyes of 30 Korean patients who underwent en-bloc excision and biopsy for tumors in the corneal and conjunctival epithelium in the suspicion of OSSN.
  
  
  RESULTS
  Tumors developed predominantly in males (21/30 patients, 70%) at the mean age of 64.8 years (range: 39-82 years). Histologic examination revealed that 11 cases were squamous cell carcinoma (SCC), eight were conjunctival or corneal intraepithelial neoplasm (CIN) with dysplastic cells in the epithelium, eight simple hyperplasia, and three inflammatory lesions. The majority of SCC (9/11 eyes, 81.8%) involved the nasal conjunctiva and cornea, while one of eight eyes (12.5%) with CIN was located at the nasal side. Vascularization was combined in all eyes with SCC, in two of eight (25%) with CIN, in two of three with inflammation, and in none with hyperplasia. Both cornea and conjunctiva were involved in ten of 11 eyes (90.9%) with SCC, in six of eight (75%) with CIN, in two of eight (25%) with hyperplasia, and in two of three (66.7%) with inflammation. When classified based on clinical appearance, seven of 11 eyes (63.6%) with SCC were papilliform sessile masses, and four of eight (50 %) with CIN showed gelatinous growth onto the surface. All lesions were treated with en-bloc excision and cryotherapy. Recurrence occurred in seven out of 19 patients (36.8%) with SCC or CIN during the mean follow-up of 30.0 months-four patients with SCC and three with CIN. Hyperplasia or lesions with inflammation did not recur. The recurrence rate was not associated with histological diagnosis of a lesion. However, the use of the postoperative chemotherapy including topical mitomycin C or interferon α 2b had a significant negative correlation with the recurrence.
  
  
  CONCLUSIONS
  In total, 36.7% of tumors in the corneal and conjunctival epithelium were SCC, and 26.7% were CIN. Recurrence occurred in 36.8% of patients with SCC or CIN after primary excision and cryotherapy. The use of postoperative chemotherapy was a significant factor negatively affecting the recurrence.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
authors.forename: Bo Hyuck
authors.initials: BH
authors.lastname: Kim
authors.forename: Mee Kum
authors.initials: MK
authors.lastname: Kim
authors.forename: Won Ryang
authors.initials: WR
authors.lastname: Wee
authors.forename: Joo Youn
authors.initials: JY
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D044466:Asian People; D002278:Carcinoma in Situ / Q000208:ethnology / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000473:pathology* / Q000628:therapy; D003230:Conjunctival Neoplasms / Q000208:ethnology / Q000473:pathology* / Q000628:therapy; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000208:ethnology / Q000473:pathology* / Q000628:therapy; D017679:Cryotherapy; D005134:Eye Neoplasms / Q000208:ethnology / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D013508:Ophthalmologic Surgical Procedures; D011994:Recombinant Proteins / Q000627:therapeutic use; D056910:Republic of Korea
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016685:Mitomycin