title: Increased serum procalcitonin levels in pregnant patients with asymptomatic bacteriuria.
abstract: BACKGROUND
  Among the pregnancy urinary tract infections, asymptomatic bacteriuria (ASB) is the most common one. Untreated ASB can progress to pyelonephritis in 30-50% of the patients and can also result in prematurity in 27% of the pregnancy so it needs immediate diagnosis and treatment. In this study, we wanted to evaluate procalcitonin levels, compared to other inflammatory in pregnant women with ASB.
  
  
  METHODS
  The study was designed between the period of January 2012 and February 2013 at Sakarya University School of Medicine, Department of Gynecology and Obstetrics. The study population included 30 pregnant patients with asymptomatic bacteriuria and 39 healthy pregnant controls.
  
  
  RESULTS
  Mean age was 28 (SD, 5.5) of the study population; mean maternal weight was 70 (SD, 8) kilogram. There were no statically significant differences between the groups according to the routine biochemical parameters, but gestational age was significantly lower in the ASB group compared to the controls (20.4 vs 28.6, respectively; p < 0.001). Serum procalcitonin levels were negative in all of the controls. In ASB group, 9 (30%) patients had procalcitonin levels greater than >0.05 ng/ml and 21(70%) patients had negative procalcitonin levels (Chi-squrae, p < 0.001). The sensitivity and specificity of procalcitonin assay for ASB was calculated as 30% and 100%, respectively. The positive predictive value was 100% and the negative predictive value was 65%. The most frequent microorganisms in the urine culture were Escherichia coli (26 patients, 87%), Proteus mirabilis (3 patients, 10%) and Klebsiella (1 patient, 3%) in the ASB group. We experienced four (44%) recurrences among nine positive procalcitonin in ASB patients after completion of treatment of the first ASB diagnosis.
  
  
  CONCLUSIONS
  Procalcitonin levels were significantly higher in ASB group than the control group and serum procalcitonin levels were higher in pregnant women with recurrent ASB. This finding is an important result revealed that high procalcitonin level can predict the further urinary tract infection risk. Finally, serum procalcitonin levels were normal in healthy pregnant women while other inflammatory markers such as WBC, ESR and CRP levels were higher.
authors.affiliation: Internal Medicine, School of Medicine, Bülent Ecevit University, Zonguldak 67100, Turkey. cebilir@yahoo.com.
authors.forename: Filiz
authors.initials: F
authors.lastname: Bilir
authors.forename: Nermin
authors.initials: N
authors.lastname: Akdemir
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ozden
authors.forename: A Serhan
authors.initials: AS
authors.lastname: Cevrioglu
authors.forename: Cemil
authors.initials: C
authors.lastname: Bilir
mesh_terms: D000328:Adult; D058345:Asymptomatic Infections; D001437:Bacteriuria / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000097:blood / Q000382:microbiology / Q000652:urine; D005260:Female; D006801:Humans; D007709:Klebsiella / Q000302:isolation & purification; D007710:Klebsiella Infections / Q000097:blood / Q000382:microbiology / Q000652:urine; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D011512:Proteus Infections / Q000097:blood / Q000382:microbiology / Q000652:urine; D011513:Proteus mirabilis / Q000302:isolation & purification
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide