title: Tyrosinase inhibitory effects and antioxidative activities of saponins from Xanthoceras Sorbifolia nutshell.
abstract: Certain saponins are bioactive compounds with anticancer, antivirus and antioxidant activities. This paper discussed inhibitory effects of saponins from Xanthoceras Sorbifolia on tyrosinase, through the research of the rate of tyrosinase catalyzed L-DOPA oxidation. The inhibition rate of tyrosinase activity presented non-linear changes with the saponins concentration. The rate reached 52.0% when the saponins concentration was 0.96 mg/ml. Antioxidant activities of saponins from Xanthoceras Sorbifolia were evaluated by using hydroxyl and superoxide radical scavenging assays. The hydroxyl radical scavenging effects of the saponins were 15.5-68.7%, respectively at the concentration of 0.18-2.52 mg/ml. The superoxide radical scavenging activity reduced from 96.6% to 7.05% with the time increasing at the concentration of 1.44 mg/ml. All the above antioxidant evaluation indicated that saponins from Xanthoceras Sorbifolia exhibited good antioxidant activity in a concentration- dependent manner.
authors.affiliation: School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, Shandong Province, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.forename: Quancheng
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000042:Absorption; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D007220:Industrial Waste; D007700:Kinetics; D007980:Levodopa / Q000737:chemistry; D014442:Monophenol Monooxygenase / Q000737:chemistry*; D009754:Nuts; D009821:Oils / Q000737:chemistry; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry; D013997:Time Factors; D014315:Triterpenes / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D016166:Free Radical Scavengers; D007220:Industrial Waste; D009821:Oils; D017382:Reactive Oxygen Species; D012503:Saponins; D014315:Triterpenes; D013481:Superoxides; D017665:Hydroxyl Radical; D007980:Levodopa; D014442:Monophenol Monooxygenase; D010100:Oxygen