title: American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.
abstract: BACKGROUND
  An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease.
  
  
  CONCLUSIONS
  Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings.
  
  
  CONCLUSIONS
  It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.
authors.affiliation: 1 Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine , Miami, Florida.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Bianco
authors.forename: Grant
authors.initials: G
authors.lastname: Anderson
authors.forename: Douglas
authors.initials: D
authors.lastname: Forrest
authors.forename: Valerie Anne
authors.initials: VA
authors.lastname: Galton
authors.forename: Balázs
authors.initials: B
authors.lastname: Gereben
authors.forename: Brian W
authors.initials: BW
authors.lastname: Kim
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kopp
authors.forename: Xiao Hui
authors.initials: XH
authors.lastname: Liao
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Obregon
authors.forename: Robin P
authors.initials: RP
authors.lastname: Peeters
authors.forename: Samuel
authors.initials: S
authors.lastname: Refetoff
authors.forename: David S
authors.initials: DS
authors.lastname: Sharlin
authors.forename: Warner S
authors.initials: WS
authors.lastname: Simonides
authors.forename: Roy E
authors.initials: RE
authors.lastname: Weiss
authors.forename: Graham R
authors.initials: GR
authors.lastname: Williams
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007037:Hypothyroidism / Q000188:drug therapy; D007455:Iodine / Q000172:deficiency / Q000378:metabolism; D007457:Iodine Radioisotopes; D023421:Models, Animal; D011247:Pregnancy; D015203:Reproducibility of Results; D012107:Research Design / Q000592:standards*; D013959:Thyroid Diseases / Q000188:drug therapy; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D007455:Iodine