title: Influence of body mass index on the growth hormone response to provocative testing in short children without growth hormone deficiency.
abstract: Obesity and its related factors are known to suppress the secretion of growth hormone (GH). We aimed to evaluate the influence of body mass index (BMI) on the peak GH response to provocative testing in short children without GH deficiency. We conducted a retrospective review of medical records of 88 children (2-15 yr old) whose height was less than 3 percentile for one's age and sex, with normal results (peak GH level > 10 ng/mL) of GH provocative testing with clonidine and dopamine. Peak stimulated GH level, height, weight, pubertal status and serum IGF-1 level were measured. Univariate analysis showed that the BMI standard deviation score (SDS) correlated negatively with the natural log (ln) of the peak stimulated GH level (ln peak GH). BMI SDS did not correlate significantly with sex, age, pubertal status, or ln IGF-1 level. BMI SDS correlated negatively with ln peak GH level induced by clonidine but not by dopamine. In stepwise multivariate regression analysis, BMI SDS was the only significant predictor of ln peak GH level in the combination of tests and the clonidine test, but not in the dopamine test. In children without GH deficiency, BMI SDS correlates negatively with the peak GH level. BMI SDS should be included in the analysis of the results of GH provocation tests, especially tests with clonidine.
authors.affiliation: Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Lee
authors.forename: Juyoung
authors.initials: J
authors.lastname: Yoon
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Kang
authors.forename: Young Ah
authors.initials: YA
authors.lastname: Lee
authors.forename: Seong Yong
authors.initials: SY
authors.lastname: Lee
authors.forename: Choong Ho
authors.initials: CH
authors.lastname: Shin
authors.forename: Sei Won
authors.initials: SW
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D004392:Dwarfism / Q000188:drug therapy; D005260:Female; D019382:Human Growth Hormone / Q000032:analysis*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003000:Clonidine; D004298:Dopamine
keywords: Body Mass Index; Clonidine; Dopamine; Growth Hormone