title: Effect of boron addition on the thermal, degradation, and cytocompatibility properties of phosphate-based glasses.
abstract: In this study eight different phosphate-based glass compositions were prepared by melt-quenching: four in the (P2O5)45-(CaO)16-(Na2O)15-x -(MgO)24-(B2O3) x system and four in the system (P2O5)50-(CaO)16-(Na2O)10-x -(MgO)24-(B2O3) x , where x = 0,1, 5 and 10 mol%. The effect of B2O3 addition on the thermal properties, density, molar volume, dissolution rates, and cytocompatibility were studied for both glass systems. Addition of B2O3 increased the glass transition (T(g)), crystallisation (T(c)), melting (T(m)), Liquidus (T(L)) and dilatometric softening (T(d)) temperature and molar volume (V(m)). The thermal expansion coefficient (α) and density (ρ) were seen to decrease. An assessment of the thermal stability of the glasses was made in terms of their processing window (crystallisation onset, T(c,ons) minus glass transition temperature, T(g)), and an increase in the processing window was observed with increasing B2O3 content. Degradation studies of the glasses revealed that the rates decreased with increasing B2O3 content and a decrease in degradation rates was also observed as the P2O5 content reduced from 50 to 45 mol%. MG63 osteoblast-like cells cultured in direct contact with the glass samples for 14 days revealed comparative data to the positive control for the cell metabolic activity, proliferation, ALP activity, and morphology for glasses containing up to 5 mol% of B2O3.
authors.affiliation: Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Nusrat
authors.initials: N
authors.lastname: Sharmin
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Hasan
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Parsons
authors.forename: David
authors.initials: D
authors.lastname: Furniss
authors.forename: Colin A
authors.initials: CA
authors.lastname: Scotchford
authors.forename: Ifty
authors.initials: I
authors.lastname: Ahmed
authors.forename: Chris D
authors.initials: CD
authors.lastname: Rudd
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology*; D001895:Boron / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects*; D010710:Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D010710:Phosphates; D001895:Boron