title: Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression.
abstract: The current study investigated the effects of green tea polyphenols (GTPs) on lipid metabolism and its mechanisms using broiler chickens (Gallus gallus domesticus). A total of 36 male chickens (35 days old) had been subjected to an oral administration of GTPs at a dosage of 0, 50 (low), and 100 (high) mg/kg of body weight for 20 days. Our results showed that GTPs significantly decreased the abdominal and subcutaneous fat masses of broilers and reduced the serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels compared to those of the control. Furthermore, the expression levels for lipid anabolism genes were significantly downregulated, while the expression levels of fat transportation and catabolism-related genes, carnitine palmitoyl transferase I (CPT-I), acyl-CoA oxidase 1 (ACOX1), and peroxisome proliferator-activated receptor-α (PPARα) in liver, adipose triglyceride lipase (ATGL) in abdominal fat, and lipoprotein lipase (LPL) in skeletal muscles, were notably upregulated. Our data have revealed that GTPs alleviate obesity and serum lipid levels in broiler chickens by suppressing fatty acid synthesis and stimulating lipolysis.
authors.affiliation: Key Laboratory of Tea Biochemistry and Biotechnology, Ministry of Agriculture and Ministry of Education, Anhui Agricultural University , 130 West Changjiang Road, Hefei 230036, Anhui, People's Republic of China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhengzhu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Xie
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wan
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects; D000818:Animals; D002645:Chickens; D005227:Fatty Acids / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000188:drug therapy / Q000662:veterinary*; D059808:Polyphenols / Q000008:administration & dosage*; D011201:Poultry Diseases / Q000188:drug therapy*; D050151:Subcutaneous Fat / Q000187:drug effects; D013662:Tea / Q000737:chemistry*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D005227:Fatty Acids; D008055:Lipids; D059808:Polyphenols; D013662:Tea; D014157:Transcription Factors