title: Systematic review of pathophysiological changes following hepatic resection.
abstract: OBJECTIVE
  Major hepatic resection is now performed frequently and with relative safety, but is accompanied by significant pathophysiological changes. The aim of this review is to describe these changes along with interventions that may help reduce the risk for adverse outcomes after major hepatic resection.
  
  
  METHODS
  The MEDLINE, EMBASE and CENTRAL databases were searched for relevant literature published from January 2000 to December 2011. Broad subject headings were 'hepatectomy/', 'liver function/', 'liver failure/' and 'physiology/'.
  
  
  RESULTS
  Predictable changes in blood biochemistry and coagulation occur following major hepatic resection and alterations from the expected path indicate a complicated course. Susceptibility to sepsis, functional renal impairment, and altered energy metabolism are important sequelae of post-resection liver failure.
  
  
  CONCLUSIONS
  The pathophysiology of post-resection liver failure is difficult to reverse and thus strategies aimed at prevention are key to reducing morbidity and mortality after liver surgery.
authors.affiliation: Department of Surgery, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Joey
authors.initials: J
authors.lastname: Siu
authors.forename: John
authors.initials: J
authors.lastname: McCall
authors.forename: Saxon
authors.initials: S
authors.lastname: Connor
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D004734:Energy Metabolism; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D017093:Liver Failure / Q000097:blood / Q000276:immunology / Q000503:physiopathology* / Q000517:prevention & control; D008115:Liver Regeneration; D012307:Risk Factors; D016896:Treatment Outcome