title: EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles.
abstract: Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram-positive and Gram-negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle-mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20-1,000 nm, which are known to contain various bioactive molecules including proteins, lipids, and nucleic acids. Here, we present EVpedia, which is an integrated database of high-throughput datasets from prokaryotic and eukaryotic extracellular vesicles. EVpedia provides high-throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non-mammalian eukaryotic, and mammalian extracellular vesicles. In addition, EVpedia also provides an array of tools, such as the search and browse of vesicular components, Gene Ontology enrichment analysis, network analysis of vesicular proteins and mRNAs, and a comparison of vesicular datasets by ortholog identification. Moreover, publications on extracellular vesicle studies are listed in the database. This free web-based database of EVpedia (http://evpedia.info) might serve as a fundamental repository to stimulate the advancement of extracellular vesicle studies and to elucidate the novel functions of these complex extracellular organelles.
authors.affiliation: Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Dae-Kyum
authors.initials: DK
authors.lastname: Kim
authors.forename: Byeongsoo
authors.initials: B
authors.lastname: Kang
authors.forename: Oh Youn
authors.initials: OY
authors.lastname: Kim
authors.forename: Dong-Sic
authors.initials: DS
authors.lastname: Choi
authors.forename: Jaewook
authors.initials: J
authors.lastname: Lee
authors.forename: Sae Rom
authors.initials: SR
authors.lastname: Kim
authors.forename: Gyeongyun
authors.initials: G
authors.lastname: Go
authors.forename: Yae Jin
authors.initials: YJ
authors.lastname: Yoon
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Su Chul
authors.initials: SC
authors.lastname: Jang
authors.forename: Kyong-Su
authors.initials: KS
authors.lastname: Park
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Choi
authors.forename: Kwang Pyo
authors.initials: KP
authors.lastname: Kim
authors.forename: Dominic M
authors.initials: DM
authors.lastname: Desiderio
authors.forename: Yoon-Keun
authors.initials: YK
authors.lastname: Kim
authors.forename: Jan
authors.initials: J
authors.lastname: Lötvall
authors.forename: Daehee
authors.initials: D
authors.lastname: Hwang
authors.forename: Yong Song
authors.initials: YS
authors.lastname: Gho
keywords: communicasomes; exosomes; membrane vesicles; microvesicles; nanocosmos; outer membrane vesicles; phylogenetic analyses; web portals