title: MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.
abstract: The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21.
authors.affiliation: Department of Pharmacology and Biology, College of Life Science and Bioengineering, Beijing University of Technology, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Yang
authors.forename: Minjun
authors.initials: M
authors.lastname: Cao
authors.forename: Yinsheng
authors.initials: Y
authors.lastname: Xu
authors.forename: Jintao
authors.initials: J
authors.lastname: Li
authors.forename: Xuebin
authors.initials: X
authors.lastname: Chen
authors.forename: Zhi
authors.initials: Z
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Xin
authors.forename: Shaomei
authors.initials: S
authors.lastname: Zhou
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Yishu
authors.initials: Y
authors.lastname: Yang
authors.forename: Wang
authors.initials: W
authors.lastname: Sheng
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D017209:Apoptosis; D001483:Base Sequence; D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D034622:RNA Interference; D047368:Tumor Burden; D020931:ran GTP-Binding Protein / Q000235:genetics* / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; C546703:MIRN203 microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; C120587:RAN protein, human; D020931:ran GTP-Binding Protein
keywords: Esophageal cancer; MiR-203; MiR-21; Ran; Tumor suppressor