title: Genetics of Alzheimer's disease.
abstract: Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease.
authors.affiliation: 401 WIDB, Department of Biology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Perry G
authors.initials: PG
authors.lastname: Ridge
authors.forename: Mark T W
authors.initials: MT
authors.lastname: Ebbert
authors.forename: John S K
authors.initials: JS
authors.lastname: Kauwe
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D058068:Endophenotypes; D020022:Genetic Predisposition to Disease; D006801:Humans