title: Definition and refinement of the 7q36.3 duplication region associated with schizophrenia.
abstract: Using a very high-resolution oligonucleotide array for copy number variant (CNV) screening of samples comprising schizophrenic patients, we detected a novel CNV within the critical region (NCBI36/hg18, Chr7: 158,630,410-158,719,410) previously shown to be associated with schizophrenia. We investigated the association between the novel CNV identified in the current study and schizophrenia. Three independent samples were used: (1) Screening set, 300 Japanese schizophrenic patients (53.28 ± 14.66 years); (2) Confirmation set, 531 schizophrenic patients (46.03 ± 12.15 years); and (3) 711 healthy controls (47.12 ± 11.03 years). All subjects enrolled in the study were Japanese. Chromosomal position was determined using fluorescence in situ hybridization. We identified a novel duplication within the region associated with schizophrenia identified on 7q36.3 that is adjacent to VIPR2 and is not associated with schizophrenia. In the Japanese population, the 35-kb region that harbors the common, novel CNV should be excluded from the region associated with schizophrenia on 7q36.3.
authors.affiliation: 1] Nagoya University, Graduate School of Medicine, Department of Psychiatry [2].
authors.forename: Branko
authors.initials: B
authors.lastname: Aleksic
authors.forename: Itaru
authors.initials: I
authors.lastname: Kushima
authors.forename: Tamae
authors.initials: T
authors.lastname: Ohye
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shohko
authors.initials: S
authors.lastname: Kunimoto
authors.forename: Yukako
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshimi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Koide
authors.forename: Shuji
authors.initials: S
authors.lastname: Iritani
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurahashi
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D058674:Chromosome Duplication; D002897:Chromosomes, Human, Pair 7; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations; D056726:Genetic Association Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*