title: [Studies on the mode of action of bacterial AB5 toxins].
abstract: Bacterial AB5 toxins are proteins, produced by pathogenic bacteria including of Vibrio cholerae, Shigella dysenteriae, and enterohaemorrhagic Escherichia coli, which are usually released into the extracellular medium and cause disease by killing or altering the metabolism of target eukaryotic cells. The toxins are usually composed of one A subunit (a toxic domain) and five B subunits (a receptor-binding domain). This article overviews the characteristics and mode of actions of AB5 toxins including cholera toxin, Shiga-like toxin, and subtilase cytotoxin, and highlights current topics related to the roles of the effectors in promoting bacterial infection.
authors.affiliation: Department of Molecular Infectiology, Chiba University Graduate School of Medicine, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Noda
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002772:Cholera Toxin / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D004196:Disease Outbreaks; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D054324:Enterohemorrhagic Escherichia coli / Q000378:metabolism* / Q000472:pathogenicity; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D005517:Foodborne Diseases / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D017434:Protein Structure, Tertiary; D022603:Shiga Toxins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D013381:Subtilisins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000737:chemistry / Q000633:toxicity*; D014613:Vaccines, Attenuated; D014734:Vibrio cholerae / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D029968:Escherichia coli Proteins; D022603:Shiga Toxins; D014613:Vaccines, Attenuated; D002772:Cholera Toxin; D013381:Subtilisins; C527234:subtilase cytotoxin, E coli