title: Corticosteroid withdrawal precipitates perilesional edema around calcified Taenia solium cysts.
abstract: Calcified Taenia solium granulomas are the focus of repeated episodes of perilesional edema and seizures in 50% of persons with calcifications, history of seizures, and a positive serology for cysticercosis. The pathophysiology is unclear but recent studies suggest the edema is caused by inflammation. We report two new cases and four other published cases where cessation of corticosteroids appeared to result in recurrence or new appearance of perilesional edema around calcifications. This suggests that perilesional edema is an immune-mediated phenomenon.
authors.affiliation: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas; Gastrointestinal Parasites Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Rojelio
authors.initials: R
authors.lastname: Mejia
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Nash
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D001929:Brain Edema / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D002114:Calcinosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D003551:Cysticercosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D003552:Cysticercus / Q000302:isolation & purification; D004334:Drug Administration Schedule; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012640:Seizures / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D041201:Taenia solium / Q000302:isolation & purification
chemical_list: D000305:Adrenal Cortex Hormones