title: Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients.
abstract: TREM2 has been reported to be associated with Alzheimer's disease (AD). Here, we evaluated TREM2 mRNA and protein expressions in peripheral blood from AD patients and healthy controls. Higher levels of TREM2 mRNA (p = 0.002) and protein (p < 0.001) were identified in AD patients. We observed a significant correlation between TREM2 expressions and MMSE score (mRNA: r = -0.482, protein: r = -0.582; p < 0.01). According to ROC curve analysis, the diagnostic accuracy for TREM2 protein levels on monocytes was 70%, with the sensitivity and specificity 68% and 72%, respectively. Our results indicate that TREM2 might serve as a novel noninvasive biomarker for AD diagnosis.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Tan
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Teng
authors.initials: T
authors.lastname: Jiang
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000235:genetics*; D008609:Mental Status Schedule; D012333:RNA, Messenger / Q000378:metabolism; D012372:ROC Curve; D011971:Receptors, Immunologic / Q000097:blood* / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
keywords: Alzheimer's disease; TREM2; biomarker; blood; diagnosis; mRNA; plasma; protein