title: The clinical measures associated with C-peptide decline in patients with type 1 diabetes over 15 years.
abstract: This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Lee
authors.forename: Ah Reum
authors.initials: AR
authors.lastname: Kwon
authors.forename: Ye Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Chae
authors.forename: Ho Seong
authors.initials: HS
authors.lastname: Kim
authors.forename: Duk Hee
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight; D002096:C-Peptide / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis*; D016883:Diabetic Ketoacidosis / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D002096:C-Peptide; D006442:Glycated Hemoglobin
keywords: Body Mass Index; Body Weight; C-Peptide; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis