title: [Antithrombotic activity of RU-891 antiaggregant agent].
abstract: Antithrombotic action of the novel benzimidazole derivative RU-891 exhibiting antiaggregant activity both in vitro and in vivo has been investigated in comparison to acetylsalicylic acid using the method of thrombosis induced by 50% ferrous chloride solution in rats. RU-891 compound showed dose-dependent antithrombotic activity exceeding that of the reference drug. Taking into account pathogenesis of this experimental thrombosis, it can be suggested that the antithrombotic action ofRU-891 is connected to its antiaggregant activity.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheriavenko
authors.forename: M
authors.initials: M
authors.lastname: Tian'
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001241:Aspirin / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology* / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005296:Ferrous Compounds; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: C583978:9-(2-(3,4-dihydroxydiphenyl)-2-oxoethyl)-2,3-dihydroimidazo(1,2-a)benzimidazole; D001562:Benzimidazoles; D005296:Ferrous Compounds; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; C029451:ferrous chloride