title: Effect of non-pharmacologic vitamin D status correction on circulating bone markers in healthy overweight and obese Saudis.
abstract: While moderate to severe vitamin D deficiency is prevalent in Saudi Arabia, skeletal effects associated with this deficiency are not common in this population. In this interventional study we measured the effects of improving vitamin D status on bone biochemical markers in overweight and obese adult Saudis. A total of 47 volunteers (21 males, 26 females) out of the initial 95 subjects were given verbal advice to expose themselves to sunlight for 5-30 min twice weekly and were encouraged to increase their intake of vitamin D-rich foods. Serum 25(OH)D, osteocalcin, and type 1 collagen cross-linked C-telopeptide (CTx), were measured at baseline and after one year. A significant decrease in the prevalence of vitamin D deficiency was observed (44% to 27%) after one year follow-up (p = 0.025). Also, a parallel significant increase in osteocalcin and a decrease in CTX and osteoprotegerin were observed. The results suggest that a modest increase in vitamin D levels among overweight and obese subjects through the promotion of lifestyle changes for one year have marginal effects in bone turnover markers as well as obesity itself.
authors.affiliation: Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. aldaghri2011@gmail.com
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Al-Daghri
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Alkharfy
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Al-Othman
authors.forename: Sobhy M
authors.initials: SM
authors.lastname: Yakout
authors.forename: Yousef
authors.initials: Y
authors.lastname: Al-Saleh
authors.forename: Mona
authors.initials: M
authors.lastname: Fouda
authors.forename: Shaun
authors.initials: S
authors.lastname: Sabico
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D024042:Collagen Type I / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D015675:Osteocalcin / Q000097:blood*; D050177:Overweight / Q000097:blood; D010455:Peptides / Q000097:blood; D015995:Prevalence; D012529:Saudi Arabia; D013472:Sunlight; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D014807:Vitamin D