title: Electrical activity of the diaphragm (EAdi) as a monitoring parameter in difficult weaning from respirator: a pilot study.
abstract: BACKGROUND
  A reliable prediction of successful weaning from respiratory support may be crucial for the overall outcome of the critically ill patient. The electrical activity of the diaphragm (EAdi) allows one to monitor the patients' respiratory drive and their ability to meet the increased respiratory demand. In this pilot study, we compared the EAdi with conventional parameters of weaning failure, such as the ratio of respiratory rate to tidal volume.
  
  
  METHODS
  We studied 18 mechanically ventilated patients considered difficult to wean. For a spontaneous breathing trial (SBT), the patients were disconnected from the ventilator and given oxygen through a T-piece. The SBT was evaluated by using standard criteria.
  
  
  RESULTS
  Twelve patients completed the SBT successfully, and six failed. The EAdi was significantly different in the two groups. We found an early increase in EAdi in the failing patients that was more pronounced than in any of the patients who successfully passed the SBT. Changes in EAdi predicted an SBT failure earlier than did conventional parameters.
  
  
  CONCLUSIONS
  EAdi monitoring adds valuable information during weaning from the ventilator and may help to identify patients who are not ready for discontinuation of respiratory support.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Barwing
authors.forename: Cristina
authors.initials: C
authors.lastname: Pedroni
authors.forename: Ulrike
authors.initials: U
authors.lastname: Olgemöller
authors.forename: Michael
authors.initials: M
authors.lastname: Quintel
authors.forename: Onnen
authors.initials: O
authors.lastname: Moerer
mesh_terms: D003964:Diaphragm / Q000502:physiology*; D006801:Humans; D007362:Intensive Care Units; D008991:Monitoring, Physiologic / Q000379:methods*; D010865:Pilot Projects; D010991:Plethysmography / Q000379:methods; D056152:Respiratory Rate / Q000502:physiology*; D015300:Ventilator Weaning / Q000379:methods*; D012122:Ventilators, Mechanical / Q000009:adverse effects