title: Drug design for flavivirus proteases: what are we missing?
abstract: Even though a number of groups have identified peptidic inhibitors for DENV and WNV proteases, and several high throughput screening campaigns have been performed, the progress towards drug candidates has been very slow. This is in stark contrast to the related NS3/NS4A protease of HCV for which two peptidomimetic drugs were approved in 2011. In this review we will compare the NS3 proteases of the flaviviruses WNV and DENV with that of HCV, and answer the question whether the flavivirus proteases are inherently more challenging, or whether the lack of success is simply due to the limited resources that have so far been invested in these neglected disease targets.
authors.forename: Anders
authors.initials: A
authors.lastname: Poulsen
authors.forename: Congbao
authors.initials: C
authors.lastname: Kang
authors.affiliation: Experimental Therapeutics Center, 31 Biopolis Way, #03-01 Nanos, Singapore 138669. thkeller@etc.a-star.edu.sg.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Keller
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D003716:Dengue Virus / Q000201:enzymology; D015195:Drug Design; D005416:Flavivirus / Q000187:drug effects / Q000201:enzymology*; D016174:Hepacivirus / Q000201:enzymology; D006801:Humans; D008958:Models, Molecular; D058990:Molecular Targeted Therapy / Q000379:methods; D020365:RNA Helicases / Q000037:antagonists & inhibitors; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D014902:West Nile virus / Q000201:enzymology; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D020365:RNA Helicases; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins; C060028:NS3 protein, flavivirus; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases