title: Recent development in [1,4]-Benzodiazepines as Potent Anticancer Agents: A Review.
abstract: The [1,4]-benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]-benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]-benzodiazepine from CNS acting drugs to anticancer agent. During last few decades, large number of reports has appeared in the literature highlighting the anticancer activity of [1,4]-benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]-benzodiazepines as anticancer agent, its mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades to till date.
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India. jitender.bariwal@gmail.com.
authors.forename: Rupinder Kaur
authors.initials: RK
authors.lastname: Gilla
authors.forename: Shiv Om
authors.initials: SO
authors.lastname: Kaushika
authors.forename: Jasreen
authors.initials: J
authors.lastname: Chugha
authors.forename: Sumit
authors.initials: S
authors.lastname: Bansalb
authors.forename: Anamik
authors.initials: A
authors.lastname: Shahc
authors.forename: Jitender
authors.initials: J
authors.lastname: Bariwala