title: Can new dentures decrease Candida levels?
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of time-course changes and various types of removable dentures on the oral levels of Candida species.
  
  
  METHODS
  In this prospective clinical trial, 72 subjects were divided into three groups according to the type of denture replaced: Kennedy Class I or II removable partial dentures (RPDs), Kennedy Class III or IV RPDs, and complete dentures. Whole saliva and biofilm samples from the palate, tongue, dentures, and inner surface of the cheek were obtained and evaluated for Candida diversity before the delivery of the new prostheses (baseline) and at 1, 6, and 12 months postdelivery. The results were analyzed using a three-way analysis of variance, followed by a post hoc Student-Newman-Keuls test.
  
  
  RESULTS
  Candida levels decreased after the insertion of the new dentures; however, after 6 months, Candida levels were similar to baseline, and complete denture wearers presented higher Candida counts than RPD wearers.
  
  
  CONCLUSIONS
  The type of denture does not seem to be a decisive factor in Candida levels. After 6 months, Candida colonization was well established in all types of removable prostheses. Denture replacement alone did not guarantee a decrease in Candida levels for more than 6 months.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Pereira-Cenci
authors.forename: Frederico S F
authors.initials: FS
authors.lastname: Fernandes
authors.forename: Jovito A
authors.initials: JA
authors.lastname: Skupien
authors.forename: Mauro E
authors.initials: ME
authors.lastname: Mesko
authors.forename: Fabiana G
authors.initials: FG
authors.lastname: Straioto
authors.forename: Atair A
authors.initials: AA
authors.lastname: Del Bel Cury
mesh_terms: D000704:Analysis of Variance; D018441:Biofilms; D002175:Candida / Q000302:isolation & purification; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology*; D003779:Denture Design; D003824:Denture, Complete / Q000382:microbiology*; D003832:Denture, Partial, Removable / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D021362:Palate, Hard / Q000382:microbiology; D011446:Prospective Studies; D019233:Retreatment; D012463:Saliva / Q000382:microbiology; D018709:Statistics, Nonparametric; D013997:Time Factors; D014059:Tongue / Q000382:microbiology