title: NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases.
abstract: The activation of the NLRP3 inflammasome leads to the autocleavage and activation of caspase-1. Caspase-1 cleaves several substrates, including the pro-inflammatory cytokine IL-1β. Inflammation, in particular IL-1β, has long been associated with the progression of metabolic disorders, and recent evidence suggests that the NLRP3 inflammasome plays a critical role in this inflammation. This review concentrates on the activation of NLRP3 during the development of metabolic disorders and the effect this activation has on the inflammatory state as well as the metabolic state of the cell.
authors.affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. mcgettra@tcd.ie
authors.forename: A F
authors.initials: AF
authors.lastname: McGettrick
authors.forename: L A J
authors.initials: LA
authors.lastname: O'Neill
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology; D053583:Interleukin-1beta / Q000502:physiology*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008659:Metabolic Diseases / Q000209:etiology* / Q000378:metabolism; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D055372:AMP-Activated Protein Kinases
keywords: AMPK; NLRP3; glycolysis; inflammasome; metabolic disorders