title: Synthesis and synergetic effects of chrysin-organogermanium (IV) complex as potential anti-oxidant.
abstract: Organogermanium(IV) (Ge) is considered to play an important role in the anti-oxidative activities of some Chinese medicines. Here, a new chrysin-organogermanium (Chry-Ge) complex was synthesized and investigated for its potential biological activities. The radicals-sensitive Ge-O bond was introduced to Chry-Ge complex to enhance bioactivities of organic Ge or Chry. Results showed that Chry-Ge complex possessed great anti-oxidative activities, showing stronger hydroxyl scavenging effects than their corresponding ligands. We also demonstrated Chry-Ge complex inhibited ROS-dependent oxidative damage in cells. Moreover, the morphological and biophysical recoveries in oxidation-damaged cells induced by Chry-Ge complex were characterized by atomic force microscopy. All these results collectively suggested that Chry-Ge complex has synergetic effect for radicals scavenging and could be served as promising pharmacologically active agent against anti-oxidative treatment.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, China.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Jiang
authors.forename: Shuguang
authors.initials: S
authors.lastname: Yao
authors.forename: Huai-Hong
authors.initials: HH
authors.lastname: Cai
authors.forename: Pei-Hui
authors.initials: PH
authors.lastname: Yang
authors.forename: Jiye
authors.initials: J
authors.lastname: Cai
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055119:Elastic Modulus / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry*; D005857:Germanium / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000378:metabolism; D018625:Microscopy, Atomic Force; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D005419:Flavonoids; D005857:Germanium; D017665:Hydroxyl Radical; C043561:chrysin
keywords: Anti-oxidant; Atomic force microscopy (AFM); Chrysin; Organogermanium; Synergistic effects