title: New leishmanicidal stilbenes from a Peruvian folk medicine, Lonchocarpus nicou.
abstract: Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9 µg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6 µg/mL, respectively).
authors.affiliation: Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Azusa
authors.initials: A
authors.lastname: Yamanaka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Obu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Kanami
authors.initials: K
authors.lastname: Mori-Yasumoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawahara
authors.forename: Diana
authors.initials: D
authors.lastname: Flores
authors.forename: Olga
authors.initials: O
authors.lastname: Palacios
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
mesh_terms: D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D008519:Medicine, Traditional; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D014344:Trypanocidal Agents