title: Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder.
abstract: Structural abnormalities in temporal lobe, including the superior temporal gyrus (STG) and planum temporale (PT), have been reported in schizophrenia (SCZ) and bipolar disorder (BPD) patients. While most MRI studies have suggested gray matter volume and surface area reduction in temporal lobe regions, few have explored changes in laminar thickness in PT and STG in SCZ and BPD. ROI subvolumes of the STG from 94 subjects were used to yield gray matter volume, gray/white surface area and laminar thickness for STG and PT cortical regions. Morphometric analysis suggests that there may be gender and laterality effects on the size and shape of the PT in BPD (n=36) and SCZ (n=31) with reduced laterality in PT in subjects with SCZ but not in BPD. In addition, PT surface area was seen to be larger in males, and asymmetry in PT surface area was larger in BPD. Subjects with SCZ had reduced thickness and smaller asymmetry in PT volume. Thus, the PT probably plays a more sensitive role than the STG in structural abnormalities seen in SCZ.
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: tilak@cis.jhu.edu.
authors.forename: J Tilak
authors.initials: JT
authors.lastname: Ratnanather
authors.forename: Clare B
authors.initials: CB
authors.lastname: Poynton
authors.forename: Dominic V
authors.initials: DV
authors.lastname: Pisano
authors.forename: Britni
authors.initials: B
authors.lastname: Crocker
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Postell
authors.forename: Shannon
authors.initials: S
authors.lastname: Cebron
authors.forename: Elvan
authors.initials: E
authors.lastname: Ceyhan
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Honeycutt
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Mahon
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Barta
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*; D012737:Sex Factors; D013702:Temporal Lobe / Q000473:pathology*
keywords: Bipolar disorder; Laminar thickness; Laterality; Planum temporale; Schizophrenia; Superior temporal gyrus