title: [The influence of spray drying process conditions on physical, chemical properties and lung inhaling performance of Panax notoginseng saponins - tanshinone II A composite particles].
abstract: This study is to report the influence of conditions in spray drying process on physical and chemical properties and lung inhaling performance of Panax notoginseng Saponins - Tanshinone II A composite particles. According to the physical and chemical properties of the two types of components within the composite particles, three solvent systems were selected including ethanol, ethanol : acetone (9 : 1, v/v) and ethanol : acetone (4 : 1, v/v), and three inlet temperature: 110 degrees C, 120 degrees C, 130 degrees C to prepare seven different composite particle samples; each sample was characterized using laser diffraction, scanning electron microscopy (SEM), dynamic vapour sorption (DVS) and atomic force microscope (AFM), and their aerodynamic behavior was evaluated by a Next Generation Impactor (NGI). The results indicate that under the conditions of using the mixed solvent system of ethanol--acetone volume ratio of 9 : 1, and the inlet temperature of 110 degrees C, the resulting composite particles showed rough surface, with more tanshinone II A distributing in the outer layer, such composite particles have the best lung inhaling performance and the fine particle fraction (FPF) close to 60%. Finally it is concluded that by adjusting the conditions in co-spray drying process, the distribution amount and existence form of tanshinone II A in the outer layer of the particles can be changed so that to enhance lung inhaling performance of the drug composite particles.
authors.affiliation: Key Laboratory of Separation Engineering for Chinese Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Hua-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Ting-Ming
authors.initials: TM
authors.lastname: Fu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Guo
mesh_terms: D045784:Abietanes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D000280:Administration, Inhalation; D003890:Desiccation; D004339:Drug Compounding / Q000379:methods*; D058995:Dry Powder Inhalers / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053723:Panax notoginseng / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D045784:Abietanes; D012503:Saponins; C021751:tanshinone