title: Incidence estimation using a single cross-sectional age-specific prevalence survey with differential mortality.
abstract: Here, we present a method for incidence estimation of a curable, non-recurring disease when data from a single cross-sectional survey are used together with population-level mortality rates and an assumption of differential mortality of diseased versus non-diseased individuals. The motivating example is cataract, and the VISION2020 goal to eliminate avoidable blindness globally by 2020. Reliable estimates of current and future cataract disease burden are required to predict how many surgeries would need to be performed to meet the VISION2020 goals. However, incidence estimates, needed to derive future burden, are not as easily available, due to the cost of conducting cohort studies. Disease is defined at the person-level in accordance with the WHO person-level definition of blindness. An extension of the standard time homogeneous illness-death model to a four-state model is described, which allows the disease to be cured, whereby surgery is performed on at least one diseased eye. Incidence is estimated, and the four-state model is used to predict disease burden assuming different surgical strategies whilst accounting for the competing risk of death. The method is applied to data from approximately 10,000 people from a survey of visual impairment in Nigeria.
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University Medical Center, 2424 Erwin Road, Suite 1102 Hock Plaza, Box 2721, Durham, NC 27710, U.S.A.; Duke Global Health Institute, Duke University, Box 90519, Durham, NC 27708, U.S.A.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Turner
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sweeting
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lindfield
authors.forename: Daniela
authors.initials: D
authors.lastname: Deangelis
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000517:prevention & control*; D002386:Cataract / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D008390:Markov Chains; D008875:Middle Aged; D015233:Models, Statistical; D009549:Nigeria; D015995:Prevalence
keywords: competing risks; conditional likelihood; differential mortality; disease burden; incidence; multi-state model