title: Evaluation of epicardial fat tissue thickness in patients with primary hyperparathyroidism.
abstract: OBJECTIVE
  Primary hyperparathyroidism (pHPT) affects the cardiovascular system, and epicardial fat tissue (EFT) thickness is closely associated with cardiovascular diseases and atherosclerosis. Despite this, the association between EFT thickness and pHPT has not been studied in a clinical setting. This study aimed to assess EFT thickness in patients with pHPT.
  
  
  METHODS
  The study included 38 patients with pHPT and 40 healthy controls. EFT thickness, carotid intima-media thickness (CIMT), serum levels of parathormone (PTH) and calcium, and blood chemistry profiles were determined in all subjects. Correlation and regression analyses were performed with EFT thickness and CIMT as dependent variables and age; systolic and diastolic blood pressure; body mass index (BMI); presence of diabetes mellitus; and free plasma glucose (FPG), PTH, and serum calcium (Ca) levels as independent variables.
  
  
  RESULTS
  Both the mean EFT thickness and the mean CIMT were significantly greater in the pHPT group than the control group (P < .001 for both). Correlation analysis showed that EFT thickness was significantly correlated with CIMT, age, systolic blood pressure, and PTH and serum Ca levels. Furthermore, the regression analysis revealed that EFT thickness retained its independent and positive association with FPG and serum Ca levels.
  
  
  CONCLUSIONS
  The results of this study indicate that EFT thickness may be a useful marker of early atherosclerosis in patients with pHPT. Furthermore, the increase in EFT thickness appears to be due to hypercalcemia.
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mehmt
authors.initials: M
authors.lastname: Asik
authors.affiliation: Department of Cardiology, Bergama Government Hospital, Izmir, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Ozkaya
authors.affiliation: Department of General Surgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozkul
authors.affiliation: Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Sen
authors.affiliation: Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Binnetoglu
authors.affiliation: Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Gunes
authors.affiliation: Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bozkurt
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Kubilay
authors.initials: K
authors.lastname: Ukinc
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010496:Pericardium / Q000473:pathology*
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium