title: Genetic and Epigenetic Regulation in Age-related Macular Degeneration.
abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the older population worldwide. While strong genetic risk factors have been associated with AMD etiology, environmental influences through epigenetic regulation are also likely to play a role. Recent advances in epigenetic studies have resulted in the development of numerous epigenetic drugs for the treatment of cancer and inflammation. Here, we review the current literature on the genetic and epigenetic mechanisms of AMD and suggest that understanding the cooperation of epigenetic and genetic mechanisms will greatly advance the clinical management of AMD.
authors.affiliation: Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA ; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA ; Zhongshan Ophthalmic Center, Guangzhou, China.
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt