title: PTGS1 compound heterozygosity impairs gene expression and platelet aggregation and is associated with severe bleeding complications.
authors.affiliation: Peter Bugert, PhD, German Red Cross Blood Service of Baden-Württemberg - Hessen gGmbH, Mannheim, Friedrich-Ebert-Strasse 107, D-68167 Mannheim, Germany, Tel.: +49 621 3706 9495, Fax: +49 621 3706 9496, E-mail: peter.bugert@medma.uni-heidelberg.de.
authors.forename: E
authors.initials: E
authors.lastname: Yagmur
authors.forename: R
authors.initials: R
authors.lastname: Weiskirchen
authors.forename: A
authors.initials: A
authors.lastname: Schedel
authors.forename: P
authors.initials: P
authors.lastname: Bugert
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000737:chemistry / Q000494:pharmacology; D000328:Adult; D016718:Arachidonic Acid / Q000172:deficiency; D001792:Blood Platelets / Q000502:physiology*; D002478:Cells, Cultured; D051545:Cyclooxygenase 1 / Q000235:genetics / Q000378:metabolism*; D056726:Genetic Association Studies; D006470:Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects / Q000235:genetics; D010979:Platelet Function Tests; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000175:diagnosis* / Q000235:genetics; D012008:Recurrence; D013931:Thromboxanes / Q000737:chemistry; D059467:Transcriptome
chemical_list: D013931:Thromboxanes; D016718:Arachidonic Acid; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human