title: Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial.
abstract: OBJECTIVE
  To examine the short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve when ovarian preservation is planned in view of determining the feasibility of conducting the study on a larger scale.
  
  
  METHODS
  Pilot randomized controlled trial.
  
  
  METHODS
  Tertiary care, academic medical center.
  
  
  METHODS
  Thirty premenopausal women aged 18 to 45 years undergoing laparoscopic hysterectomy with ovarian preservation for benign indications from April 2012 to September 2012.
  
  
  METHODS
  Bilateral salpingectomy (n = 15) versus no salpingectomy (n = 15) at the time of laparoscopic hysterectomy with ovarian preservation.
  
  
  METHODS
  Antimüllerian hormone (AMH) measured preoperatively, at 4 to 6 weeks postoperatively, and at 3 months postoperatively, with operative time and estimated blood loss abstracted from the medical records.
  
  
  RESULTS
  The mean AMH levels were not statistically significantly different at baseline (2.26 vs. 2.25 ng/ml), 4 to 6 weeks postoperatively (1.03 vs. 1.25 ng/ml), or 3 months postoperatively (1.86 vs. 1.82 ng/ml) among women with salpingectomy versus no salpingectomy, respectively. There was also no statistically significant temporal change in the mean AMH level from baseline to 3 months postoperatively (-0.07 vs. -0.08 ng/ml) between the two groups. No difference in operative time (116 vs. 115 minutes) or estimated blood loss (70 vs. 91 mL) was observed.
  
  
  CONCLUSIONS
  Salpingectomy at the time of laparoscopic hysterectomy with ovarian preservation is a safe procedure that does not appear to have any short-term deleterious effects on ovarian reserve, as measured by AMH level. Conducting a trial of this nature that is adequately powered with long-term follow-up evaluation would be feasible and is required to definitively confirm these results.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: austin_findley@med.unc.edu.
authors.forename: Austin D
authors.initials: AD
authors.lastname: Findley
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Siedhoff
authors.forename: Kumari A
authors.initials: KA
authors.lastname: Hobbs
authors.forename: John F
authors.initials: JF
authors.lastname: Steege
authors.forename: Erin T
authors.initials: ET
authors.lastname: Carey
authors.forename: Christina A
authors.initials: CA
authors.lastname: McCall
authors.forename: Anne Z
authors.initials: AZ
authors.lastname: Steiner
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007247:Infertility, Female / Q000175:diagnosis* / Q000209:etiology*; D010535:Laparoscopy / Q000009:adverse effects*; D008594:Menopause, Premature; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000517:prevention & control; D010060:Ovulation; D010865:Pilot Projects; D017697:Premenopause; D058994:Salpingectomy / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Antimüllerian hormone; hysterectomy; ovarian reserve; salpingectomy