title: Hepatoid adenocarcinoma of the anterior skull base: a case report.
abstract: We report the first case of hepatoid adenocarcinoma of the skull base, as well as the first reported case in the head and neck region. Hepatoid adenocarcinoma is a rare, aggressive, extrahepatic malignancy with a distinct morphological similarity to hepatocellular carcinoma, in the absence of primary hepatic disease. A 45-year-old man presented with sinus headaches and retro-orbital pain and was found to have a nasopharyngeal mass on endoscopy and a large, destructive sinonasal mass extending intracranially on imaging. Histo- and cytopathological features were similar to hepatocellular carcinoma, and the cells were immunoreactive for α-fetoprotein, epithelial membrane antigen, periodic acid-Schiff, cytokeratin (CK)8/18, CK19, and S100.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Zener
authors.forename: Olga
authors.initials: O
authors.lastname: Gologan
authors.forename: Noah
authors.initials: N
authors.lastname: Sands
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Zeitouni
keywords: AFP; Hepatoid adenocarcinoma; sinonasal tumors; skull base tumors