title: An unusual cause of ischemic stroke with successful thrombolysis.
abstract: A 63-year-old woman was admitted because of sudden ischemic hemyplegia promptly cleared up by intravenous (IV) recombinant tissue plasminogen activator. On subsequent 2-dimensional echocardiogram, we observed an extremely mobile homogeneous mass attached by a short stalk to ventricular insertion of anterolateral papillary muscle chordae tendineae. The mass was surgically removed. Gross anatomy showed a mass with a gelatinoids appearance formed on histology by a lining of hyperplastic endocardial cells covering a hypocellular stroma consistent with papillary fibroelastoma. Given the prompt clinical improvement with IV thrombolytic therapy, we postulate that cerebral artery occlusion was at least in part because of thrombotic material.
authors.affiliation: Department of Cardiology, Ospedale Valduce, Como, Italy. Electronic address: gcorr@iol.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corrado
authors.forename: Paolo
authors.initials: P
authors.lastname: Panisi
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Checcarelli
authors.forename: Luciana
authors.initials: L
authors.lastname: Ambrosiani
mesh_terms: D061605:Administration, Intravenous; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006348:Cardiac Surgical Procedures; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005350:Fibroma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006338:Heart Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Cardiac source of embolism; echocardiography; papillary fibroelastoma; stroke