title: [Study on preparation and optimization of saikoside liposomes].
abstract: OBJECTIVE
  To optimize the prescription and technique for preparing saikoside (SS) liposomes and evaluate its quality.
  
  
  METHODS
  The preparation methods of liposomes included film dispersion, ether injection, reverse phase evaporation and pH gradients were explored. The encapsulation ratio was determined by macroreticular resin method. The main factors affecting encapsulation ratio were studied by single factor analysis and central composite design.
  
  
  RESULTS
  The appearance of SS liposomes prepared by optimized method was satisfactory. The encapsulation ratio was more than 60% and the verage particle size of SS liposomes was 110 nm.
  
  
  CONCLUSIONS
  The formulation and preparation process is practical and simple for the preparation of SS liposomes. It is valuable to be further studied.
authors.affiliation: School of Pharmacy, Henan University of TCM, Zhengzhou 450046 China. guanyanbin96@126.com
authors.forename: Yan-Bin
authors.initials: YB
authors.lastname: Guan
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Tian
authors.forename: Yong-Yan
authors.initials: YY
authors.lastname: Jia
authors.forename: Xiao-Zhi
authors.initials: XZ
authors.lastname: Tian
mesh_terms: D029972:Bupleurum / Q000737:chemistry*; D002784:Cholesterol / Q000008:administration & dosage / Q000737:chemistry; D019343:Citric Acid / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D010316:Particle Size; D010743:Phospholipids / Q000008:administration & dosage* / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012117:Resins, Synthetic; D012503:Saponins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D012117:Resins, Synthetic; D012503:Saponins; D019343:Citric Acid; D009828:Oleanolic Acid; D002784:Cholesterol; C025759:saikosaponin D