title: [Ketamine for treatment of acute depression].
abstract: In clinical trials a single dose of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown a rapid antidepressant effect in patients with treatment-resistant depression and bipolar depression. The implications of glutaminergic mechanisms in depression and the rapid effect of a single dose of ketamine could open new pathways to understand the pathophysiology of depression and the development of novel rapid-acting antidepressant drugs.
authors.affiliation: Center for Psykiatrisk Forskning, Aarhus Universitetshospital, Risskov, Skovagervej 2, 8240 Risskov. simon@dadlnet.dk.
authors.forename: Simon
authors.initials: S
authors.lastname: Hjerrild
authors.forename: Johannes
authors.initials: J
authors.lastname: Bjerre
authors.forename: Rasmus Hjuler
authors.initials: RH
authors.lastname: Pedersen
authors.forename: Poul
authors.initials: P
authors.lastname: Videbech
mesh_terms: D000208:Acute Disease; D059846:Analgesics, Short-Acting / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D016896:Treatment Outcome
chemical_list: D059846:Analgesics, Short-Acting; D000778:Anesthetics, Dissociative; D000928:Antidepressive Agents; D018691:Excitatory Amino Acid Antagonists; D010919:Placebos; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine