title: Deep hypothermic circulatory arrest: real-life suspended animation.
abstract: Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that was developed in the 1950s and popularized in the 1970s. It has become one of the three most common cerebral protection techniques currently used in aortic arch surgeries, with the other two being antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP). At our institution, DHCA has been the cerebral protection technique of choice for over a quarter century. Our clinical experience with DHCA has been very positive, and our clinical studies have shown DHCA to have outcomes equal to (and sometimes better than) those of ACP and RCP, and DHCA to be very effective at preserving neurocognitive function. Other institutions, however, prefer ACP or RCP to DHCA. Each technique has its own set of pros and cons, and the question regarding which technique is the superior method for cerebral protection is hotly debated.
authors.affiliation: Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
authors.forename: Katherine H
authors.initials: KH
authors.lastname: Chau
authors.forename: Bulat A
authors.initials: BA
authors.lastname: Ziganshin
authors.forename: John A
authors.initials: JA
authors.lastname: Elefteriades
mesh_terms: D000818:Animals; D017545:Aortic Aneurysm, Thoracic / Q000266:history / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000266:history / Q000401:mortality; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000266:history / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control*; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000009:adverse effects / Q000266:history / Q000401:mortality; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010477:Perfusion; D016896:Treatment Outcome
keywords: ACP; Aortic arch aneurysms; CPB; Cerebral protection; DHCA; Deep hypothermic circulatory arrest; EKG; N-methyl-D-aspartate; NMDA; RCP; Real-life suspended animation; antegrade cerebral perfusion; cardiopulmonary bypass; deep hypothermic circulatory arrest; electrocardiogram; retrograde cerebral perfusion