title: The association between CCL2 polymorphisms and drug-resistant epilepsy in Chinese children.
abstract: The treatment of drug-resistant epilepsy remains a major challenge, affecting approximately 30% of epilepsy patients. More recently, immunity and inflammation are considered to be key elements of epilepsy. Targeting brain inflammation may represent a novel therapeutic strategy for epilepsy and refractory epilepsy. In this study, we investigated the association of a tag SNP of the CCL2 gene, rs1024611 (originally designated as -2578G>A or -2518G>A) with drug-resistant epilepsy in Chinese children with epilepsy. We enrolled 484 epilepsy patients, including 98 drug-resistant patients and 386 drug-responsive patients. The rs1024611 was genotyped by PCR-RPLP. The rs1024611 AA genotype was associated with a greater susceptibility to drug-resistant epilepsy (p=0.008; OR=2.51, 95% CI: 1.33-4.72), adjusted for age, sex, and seizure type, and the association remained significant after Bonferroni correction for multiple testing (p<0.05). Our results demonstrate that the CCL2 genetic polymorphism is associated with drug-resistant epilepsy in Chinese paediatric patients.
authors.affiliation: Department of Neurology, Authors contributed equally.
authors.forename: Xuelian
authors.initials: X
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Yue
authors.forename: Peiwei
authors.initials: P
authors.lastname: Zhao
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Hu
authors.forename: Gefei
authors.initials: G
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Mao
authors.forename: Dan
authors.initials: D
authors.lastname: Sun
authors.forename: Huanian
authors.initials: H
authors.lastname: Zhang
authors.forename: Xinwen
authors.initials: X
authors.lastname: Song
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Shao
mesh_terms: D000483:Alleles; D044466:Asian People; D001812:Blood-Brain Barrier / Q000503:physiopathology; D018932:Chemokine CCL2 / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015810:Linkage Disequilibrium; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D018932:Chemokine CCL2; D018836:Inflammation Mediators