title: Chemical approaches to stem cell biology and therapeutics.
abstract: Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.
authors.affiliation: Department of Cell Biology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Wenlin
authors.initials: W
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Wanguo
authors.initials: W
authors.lastname: Wei
authors.forename: Sheng
authors.initials: S
authors.lastname: Ding
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D058990:Molecular Targeted Therapy / Q000639:trends; D039904:Pluripotent Stem Cells / Q000187:drug effects / Q000502:physiology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044968:Regenerative Medicine / Q000639:trends; D054852:Small Molecule Libraries; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines; C515825:SC1 compound; D054852:Small Molecule Libraries