title: [Determination of musk ketone in aquatic products by gas chromatography-mass spectrometry with dispersive solid phase extraction].
abstract: A dispersive solid phase extraction coupled with gas chromatography-mass spectrometry (GC-MS) method was established for the determination of trace amounts of musk ketone in aquatic products. The target analyte in the samples was extracted with acetonitrile containing 1% acetic acid, cleaned-up with the mixture of N-propyl-ethylenediamine (PSA), C18 and graphitized carbon (GCB), and analyzed by GC-MS under selected ion monitoring (SIM) mode and quantified by the external standard method. The orthogonal experiment was carried out to optimize the pre-treatment conditions. Under the optimal conditions, good linear relationship was obtained in the range of 1 - 50 microg/L for musk ketone with correlation coefficient not less than 0.999, and the limits of detection (S/N = 3) was 0.30 microg/kg. The recoveries of musk ketone in the prawn and tilapia blank samples at three spiked levels of 1.0, 2.0 and 10.0 microg/kg ranged from 91.8% to 110.6% with RSDs in the range of 2.6% - 8.4%. The method is simple, rapid and accurate, and can be used for the routine analysis of musk ketone in aquatic products.
authors.affiliation: Technology Center of Fuqing Entry-Exit Inspection and Quarantine Bureau, Fuqing 350300, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Ding
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Chen
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D017747:Seafood / Q000032:analysis*; D052616:Solid Phase Extraction; D014992:Xylenes / Q000032:analysis*
chemical_list: D014992:Xylenes; C031448:musk ketone