title: [Clinical target volume delineation for radiotherapy of the esophagus].
abstract: The dense lymphatic network of the esophagus facilitates tumour spreading along the cephalo-caudal axis and to locoregional lymph nodes. A better understanding of microscopic invasion by tumour cells, based on histological analysis of surgical specimens and analysis of recurrence sites, has justified a reduction in radiotherapy target volumes. The delineation of the clinical target volume (CTV) depends on tumour characteristics (site, histology) and on its spread as assessed on endoscopic ultrasonography and ((18)F)-fluorodeoxyglucose positron-emission tomography (FDG-PET). We propose that positive and negative predictive values for FDG-PET should be used to adapt the CTV according to the risk of nodal involvement.
authors.affiliation: Département de radiothérapie et de physique médicale, QuantIF-Litis (EA4108), centre Henri-Becquerel, 1, rue d'Amiens, 76000 Rouen, France. Electronic address: ioana.lazarescu1@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Lazarescu
authors.forename: S
authors.initials: S
authors.lastname: Thureau
authors.forename: L
authors.initials: L
authors.lastname: Nkhali
authors.forename: O
authors.initials: O
authors.lastname: Pradier
authors.forename: B
authors.initials: B
authors.lastname: Dubray
mesh_terms: D019160:Endosonography; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000528:radiation effects; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cancer de l’œsophage; Clinical target volume; Conformal radiotherapy; Esophageal cancer; FDG-PET; Negative predictive value; Positive predictive value; Radiothérapie conformationnelle; TEP au FDG; Valeur prédictive négative; Valeur prédictive positive; Volume cible anatomoclinique