title: Xylitol lozenges were not effective in overall dental caries prevention in adults.
abstract: BACKGROUND
  Results from the xylitol for adult caries trial (X-ACT). Bader JD, Vollmer WM, Shugars DA, Gilbert GH, Amaechi BT, Brown JP, Laws RL, Kunkhouser KA, Makhija SK, Ritter AV, Leo MC. JADA 2013; 144(1): 21-30.
  
  
  METHODS
  Margherita Fontana, DDS, PhD, Carlos Gonzalez-Cabezas, DDS, MSD, PhD PURPOSE/QUESTION: Among an adult population at risk of dental caries, does the use of five 1 g xylitol lozenges per day over 33 months reduce the experience of cavitated caries lesions?
  
  
  BACKGROUND
  Government: National Institute of Dental and Craniofacial Research
  
  
  METHODS
  Multicenter, double blind, placebo-controlled, randomized clinical trial
  
  
  METHODS
  Level 1: Good quality, patient-oriented evidence
  
  
  METHODS
  B: Limited quality patient-oriented evidence.
authors.affiliation: Associate Professor, Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N University, Ann Arbor, MI 48109, USA. Electronic address: mfontan@umich.edu.
authors.forename: Margherita
authors.initials: M
authors.lastname: Fontana
authors.forename: Carlos
authors.initials: C
authors.lastname: Gonzalez-Cabezas
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D013549:Sweetening Agents / Q000627:therapeutic use*; D014993:Xylitol / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D013549:Sweetening Agents; D014993:Xylitol