title: On the association between lipopolysaccharide induced catalepsy and serotonin metabolism in the brain of mice genetically different in the predisposition to catalepsy.
abstract: The study of the interaction between nervous and immune systems in the mechanism of psychopathology is an important problem of neuroscience. Catalepsy (freezing reaction) is a passive defensive strategy in response to threatening stimuli. An exaggerated form of catalepsy is a syndrome of some grave mental disorders. Both the brain serotonin (5-HT) and immune systems were shown to be involved in the mechanism of catalepsy. Here we compared the effects of two doses (50 or 200 μg/kg, ip) of innate immune system activator, bacterial lipopolysaccharide (LPS), on catalepsy, 5-HT and its main metabolite, 5-hydroxyindole acetic acid (5-HIAA) in the hippocampus, striatum, and midbrain of mice of catalepsy-prone (CBA/Lac and AKR.CBA-D13Mit76) and catalepsy-resistant (AKR/J) strains. The expression of LPS-induced catalepsy as well as 5-HIAA/5-HT ratio in the midbrain and striatum were significantly higher in mice of the catalepsy-prone strains compared with animals of the catalepsy-resistant strains. These results indicated an involvement of the brain 5-HT system in the cataleptogenic effect of LPS and open up new vistas for understanding the nervous-immune mechanism of behavioral disorders.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. Electronic address: Kata_Yurevna@mail.ru.
authors.forename: Ekaterina Yu
authors.initials: EY
authors.lastname: Bazhenova
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: Maria A
authors.initials: MA
authors.lastname: Tikhonova
authors.forename: Daria V
authors.initials: DV
authors.lastname: Bazovkina
authors.forename: Daria V
authors.initials: DV
authors.lastname: Fursenko
authors.forename: Nina K
authors.initials: NK
authors.lastname: Popova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002375:Catalepsy / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012701:Serotonin / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D012701:Serotonin
keywords: Brain; Catalepsy; Lipopolysaccharide; Mice; Serotonin metabolism