title: Six-year pilot study on nucleic acid testing for blood donations in China.
abstract: A six-year pilot study on nucleic acid testing for HBV, HCV and HIV-1 has been undertaken on sero-negative plasmas in mini-pool and individual donation testing at Shenzhen Blood Center. Of 307,740 sero-negative blood samples, 95 of 102 HBV DNA yields were confirmed positive, 80/95 (84.2%) were classified as occult HBV infection (OBI) and 15 (15.8%) as window period cases. Amongst OBIs, 45% carried anti-HBc only, 41.3% anti-HBc and anti-HBs and 13.7% anti-HBs only. HBV DNA yield was 1:3239. One HCV WP and one HIV-1 infected donations were detected. High residual risk was found in current blood donations screening in China.
authors.affiliation: Shenzhen Blood Centre, Shenzhen, China.
authors.forename: Xianlin
authors.initials: X
authors.lastname: Ye
authors.forename: Baocheng
authors.initials: B
authors.lastname: Yang
authors.forename: Weigang
authors.initials: W
authors.lastname: Zhu
authors.forename: Xin
authors.initials: X
authors.lastname: Zheng
authors.forename: Peng
authors.initials: P
authors.lastname: Du
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zeng
authors.forename: Chengyao
authors.initials: C
authors.lastname: Li
mesh_terms: D001782:Blood Donors; D002681:China; D004279:DNA, Viral / Q000097:blood*; D046148:Donor Selection / Q000379:methods*; D005260:Female; D015497:HIV-1; D016174:Hepacivirus; D006515:Hepatitis B virus; D006801:Humans; D008297:Male; D010865:Pilot Projects; D012367:RNA, Viral / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral
keywords: Blood donors; Blood safety; Nucleic acid testing; Viruses