title: Forever (FGF) 21.
abstract: The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity. Two new studies in mice show that Fgf21 interacts directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting.
authors.affiliation: Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Chicago, Illinois, USA, and the Department of Neurobiology, Northwestern University, Evanston, Illinois, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bass
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D000090265:Klotho Proteins; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*
chemical_list: C418622:Klb protein, mouse; D008565:Membrane Proteins; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D000090265:Klotho Proteins