title: A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration.
abstract: A facile strategy for the preparation of two isomeric drospirenones 13 and 16 possessing a 14β-hydrogen was developed, using 3β-hydroxyandrost-5-en-17-one as the starting material. The total synthetic route involves eight steps, giving 2% overall yield. The structures of the main compounds 11, 13, 14 and 16 were determined by single crystal XRD analysis.
authors.affiliation: Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China. jhao@staff.shu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Wan
authors.forename: Guobin
authors.initials: G
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Shangqin
authors.initials: S
authors.lastname: Rao
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zheng
authors.forename: Haizhen
authors.initials: H
authors.lastname: Jiang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Deng
authors.forename: Jian
authors.initials: J
authors.lastname: Hao
mesh_terms: D000736:Androstenes / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000736:Androstenes; D006859:Hydrogen; C035144:drospirenone