title: Correlation of the serum insulin and the serum uric Acid levels with the glycated haemoglobin levels in the patients of type 2 diabetes mellitus.
abstract: BACKGROUND
  Type 2 Diabetes mellitus (DM) is a heterogeneous disease which is characterized by variable degrees of insulin resistance and impaired insulin secretion. Insulin is a hormone that regulates the body's use of glucose. The present study was undertaken to find the correlation of the serum uric acid levels in the patients of Type 2 Diabetes mellitus.
  
  
  METHODS
  This was a case control study. The subjects who were included in the study were divided into two groups. Group A included 50 normal healthy individuals who were in the age group of 40-65 years, who were of either sex and with no family history of Diabetes mellitus. Group B included 50 newly diagnosed patients of Type 2 Diabetes Mellitus, who were in the age group of 40-65 years, who were of either sex, from the same population. Fasting blood samples were drawn and they were investigated for the serum insulin, serum uric acid, fasting blood sugar and the HbA1C levels. The values were compared with those of normal healthy subjects.
  
  
  RESULTS
  All the three parameters, HbA1C, serum insulin and serum uric acid were found to be increased in the patients of Type 2 Diabetes Mellitus as compared to their levels in the controls (p<0.001).
  
  
  CONCLUSIONS
  In the present study, it was concluded that the serum uric acid levels linearly increased with increasing serum insulin levels, in newly diagnosed diabetic patients. Therefore, uric acid serves as a potential biomarker of the glucose metabolism.
authors.affiliation: Assistant Professor, Department of Biochemistry, Sri Guru Ram Das Institute of Medical Sciences and Research , Sri Amritsar, India .
authors.forename: Anju
authors.initials: A
authors.lastname: Gill
authors.forename: Sahiba
authors.initials: S
authors.lastname: Kukreja
authors.forename: Naresh
authors.initials: N
authors.lastname: Malhotra
authors.forename: Namrata
authors.initials: N
authors.lastname: Chhabra
keywords: Fasting Blood Sugar (FBS); Glycated Haemoglobin (HbA1C); Serum Insulin