title: [Experimental therapy of cardiac remodeling with quercetin-containing drugs].
abstract: It was shown that continuous beta-adrenergic hyperstimulation resulted in cardiac function disturbances and fibrosis of cardiac tissue. Treatment with quercetin-containing drugs, particularly, water-soluble corvitin and tableted quertin exerted favourable effect on cardiac hemodynamics, normalized systolic and diastolic function in cardiac remodeling, induced by sustained beta-adrenergic stimulation. It was estimated that conducted experimental therapy limited cardiac fibrosis area almost three-fold, that could be associated with first and foremost improved cardiac distensibility, characteristics of diastolic and also pump function in cardiac remodeling.
authors.affiliation: Bogomoletz Institute of Physiology, Kyiv, Ukraine
authors.forename: M A
authors.initials: MA
authors.lastname: Kuzmenko
authors.forename: V B
authors.initials: VB
authors.lastname: Pavlyuchenko
authors.forename: L V
authors.initials: LV
authors.lastname: Tumanovskaya
authors.forename: V E
authors.initials: VE
authors.lastname: Dosenko
authors.forename: A A
authors.initials: AA
authors.lastname: Moybenko
mesh_terms: D018663:Adrenergic Agents / Q000633:toxicity; D000818:Animals; D005355:Fibrosis / Q000188:drug therapy; D006331:Heart Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006439:Hemodynamics; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology*; D011794:Quercetin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018663:Adrenergic Agents; D011794:Quercetin