title: Exertional heat stroke, rhabdomyolysis and susceptibility to malignant hyperthermia.
abstract: Unexpectedly severe exertional heat stroke and rhabdomyolysis should prompt a clinician to look for susceptibility to malignant hyperthermia. We report a case of exertional heat stroke and rhabdomyolysis in a man later determined to have the malignant hyperthermia phenotype. We review the existing literature regarding this association and suggest future research that could address areas of remaining clinical uncertainty.
authors.affiliation: School of Medicine, University of Adelaide, Adelaide, South Australia, Australia. thomas.crowhurst@student.adelaide.edu.au
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: T
authors.initials: T
authors.lastname: Crowhurst
mesh_terms: D000328:Adult; D004198:Disease Susceptibility; D018883:Heat Stroke / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000150:complications / Q000175:diagnosis*; D005082:Physical Exertion / Q000502:physiology*; D012206:Rhabdomyolysis / Q000150:complications / Q000175:diagnosis*; D012420:Running / Q000502:physiology*
keywords: genetic testing; heat stroke; malignant hyperthermia; pharmacogenetics; rhabdomyolysis