title: Crimean-Congo hemorrhagic fever virus nucleoprotein suppresses IFN-beta-promoter-mediated gene expression.
abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the family Bunyaviridae and is a causative agent of severe hemorrhagic disease. Knowledge regarding the pathogenesis of CCHFV is limited due to the requirement for high-containment laboratories and the lack of an immunocompetent animal host. Previous studies have shown that CCHFV delays the activation of the human innate immune response, specifically, the type I interferon response. Our study results show that antagonism of the interferon-beta promoter is mediated by the nucleoprotein of CCHFV strain Hoti, while strains IbAr10200 and AP92 do not suppress the activity of the IFN-beta promoter. Our results also suggest that several viral factors may provide antagonistic action against the type I interferon response.
authors.affiliation: Institute of Microbiology and Immunology, Ljubljana, Slovenia.
authors.forename: Luka
authors.initials: L
authors.lastname: Fajs
authors.forename: Katarina
authors.initials: K
authors.lastname: Resman
authors.forename: Tatjana
authors.initials: T
authors.lastname: Avšič-Županc
mesh_terms: D002460:Cell Line; D015870:Gene Expression; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D016899:Interferon-beta / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D009698:Nucleoproteins / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D009698:Nucleoproteins; D014764:Viral Proteins; D016899:Interferon-beta