title: Coamplification and cooperation: toward identifying biologically relevant oncogenes.
abstract: Identification of biologically relevant genes from genomic assays is limited by the complexity of changes present in most solid tumors. Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas.
authors.affiliation: Authors' Affiliation: Laboratory of Epithelial Cancer Biology, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Guochang
authors.initials: G
authors.lastname: Huang
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Singh
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D005784:Gene Amplification; D023281:Genomics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009857:Oncogenes