title: [Analysis of CD4(+) T cell function in patients suffered from pulmonary infection in the early phase after haploidentical hematopoietic stem cell transplantation].
abstract: This study was purposed to investigate the immune state of the patients suffered from pulmonary infection within 6 months after haploidentical hematopoietic stem cell transplantation (hi-HSCT). Adenosine triphosphate (ATP) value in CD4(+) T cells was measured by ImmuKnow method to assess the function of the lymphocytes in peripheral blood of 25 patients at 6 months after hi-HSCT. The results showed that the ATP level in CD4(+) T cells of the patients suffered from pulmonary infection was (179.88 ± 65.41) ng/ml before transplantation, (172.69 ± 118.81) ng/ml at 1 month, (218.15 ± 124.26) ng/ml at 3 months, (313.42 ± 116.29) ng/ml at 6 months after transplantation. The ATP level in CD4(+) T cells of the patients without pulmonary infection was (210.44 ± 94.71) ng/ml before transplantation, and decreased to (193.66 ± 133.69) ng/ml at 1 month and increased gradually to (355.02 ± 43.38) ng/ml at 3 months, (355.73 ± 93.85) ng/ml at 6 months after transplantation. It is concluded that the low ATP value in CD4(+) T cells in patients prior and post hi-HSCT may suggest probability of occurrence for infections, ATP value in CD4(+) T cells may be used as a reference indicator for clinical empirical use of antibiotics.
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, China; Department of Hematoloyg, General Hospital of Chinese Air Force, Beijing 100042, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zheng
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Han
authors.forename: Heng
authors.initials: H
authors.lastname: Zhu
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Yan
authors.forename: Zi-Kuan
authors.initials: ZK
authors.lastname: Guo
authors.forename: Heng-Xiang
authors.initials: HX
authors.lastname: Wang
authors.forename: Chu-Tse
authors.initials: CT
authors.lastname: Wu
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000276:immunology* / Q000473:pathology; D055815:Young Adult
chemical_list: D000255:Adenosine Triphosphate