title: Clinicopathologic features and prognostic factors of malignant eyelid tumors.
abstract: OBJECTIVE
  To investigate the clinical characteristics and prognosis of patients with malignant eyelid tumors.
  
  
  METHODS
  This was a retrospective, non-randomized, clinical reviews. Between January, 2002 and December, 2011, 75 cases with histologically confirmed malignant eyelid tumors were evaluated. Patients' charts were reviewed for clinical information, treatment procedure, and disease course. Survival analysis in terms of recurrence-free survival was performed using age, sex, location of tumor and histopathological type. The follow-up ranged from 1 to 78 months (mean=21 months).
  
  
  RESULTS
  The 75 eyelid tumors included 35 basal cell carcinoma (BCC, 46.7%), 22 sebaceous gland carcinoma (SGC, 29.3%), 7 squamous cell carcinoma (SCC, 9.3%), 10 malignant melanoma (MM, 13.3%), and 1 Merkel cell carcinoma (MCC, 1.3%). Recurrence developed in 17 cases (22.7%). The recurrence rate of BCC (4/35, 11.4%) was significant lower than MM (6/10, 60.0%, P<0.001). The mean interval of recurrence was 21 months (range 3-62) for all eyelid tumors. Tumor located at canthus had higher recurrence rate (50%) compared with those located at eyelid (19%, P<0.05). Histological type was independent variable for recurrence by Cox regression analysis.
  
  
  CONCLUSIONS
  It is important to achieve a negative tumor margin in canthus located malignant eyelid tumor. Clinicians should have a high level of suspicion for recurrence according to histological type when treating patients with eyelid tumor.
authors.affiliation: Eye Center, the Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Wang
authors.forename: Hui-Na
authors.initials: HN
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Wu
authors.forename: Xin
authors.initials: X
authors.lastname: Shi
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Xie
authors.forename: Jin-Jing
authors.initials: JJ
authors.lastname: He
authors.forename: Koung-Hoon
authors.initials: KH
authors.lastname: Kook
authors.forename: Sang-Yeul
authors.initials: SY
authors.lastname: Lee
authors.forename: Juan
authors.initials: J
authors.lastname: Ye
keywords: eyelid tumors; histological type; location; recurrence