title: [The effect of betahistine on histological changes in rabbit brain in model of whole body wide-frequency vibration].
abstract: In acute experiments in conscious rabbits was studied protective action of selective blocker of histamine H3-receptor betahistine (2mg/kg i/v) against histological changes in precentral and postcentral gyrus, as well as in temporal lobe of cerebral cortex, thalamus, hypothalamus, and cerebellum, arising in case of modeling of whole body wide-frequency vibration. Betahistine attenuates edematous and degenerative changes in neurons and reciprocal glial reaction, caused by vibration, but does not eliminate edema in perivascular spaces. This effect may be related to the improvement of blood supply as a result of of vasodilatory action and decrease of oxygen consumption via vestibuloprotective effect.
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Shimkus
authors.forename: I D
authors.initials: ID
authors.lastname: Sapegin
mesh_terms: D000818:Animals; D001621:Betahistine / Q000494:pharmacology*; D002531:Cerebellum / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D004487:Edema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D017442:Histamine Agonists / Q000494:pharmacology*; D007031:Hypothalamus / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*; D014732:Vibration / Q000009:adverse effects
chemical_list: D017442:Histamine Agonists; D014665:Vasodilator Agents; D001621:Betahistine