title: Antioxidant polyketide phenolic metabolites from the edible mushroom Cortinarius purpurascens.
abstract: Phytochemical investigation of the ethyl acetate extract of the edible macrofungus, Cortinarius purpurascens, led to the isolation of nine anthraquinone-related pigments, citreorosein 6,8-dimethyl ether (1), physcione (2), rufoolivacin (3), rufoolivacin C (4), rufoolivacin D (5), leucorufoolivacin (6), verbindung cr11 (7), verbindung cr60 (8) and 1-Hydroxy-3-methyl-2-isopropanyl-6,8-dimethoxyanthraquinone (9). The structures of these isolated compounds were characterised by spectroscopic methods and comparison with published data. Among the tested compounds, 3-6 exhibited potent DPPH radical-scavenging activity with IC50 values in the range of 3-8 μg/ml. The results indicated that the fungus is a possible source of natural products with potential antioxidant activity.
authors.affiliation: Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Bai
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Shi-Chun
authors.initials: SC
authors.lastname: Zong
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism; D055363:Cortinarius / Q000737:chemistry* / Q000378:metabolism; D055951:Functional Food / Q000032:analysis; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D010636:Phenols; D061065:Polyketides
keywords: Anthraquinones; Antioxidant activity; Cortinarius purpurascens; Fungal pigments; Polyketides