title: Urinary 6-sulphatoxymelatonin levels and sleep disorders in children with migraine.
abstract: We conducted the present study to assess melatonin secretion in a sample of children with migraine, to describe their sleep patterns and problems, and to examine the impact of sleep problems on migraine disability. The parents of 18 children with migraine completed the Children's Sleep Habits Questionnaire and Pediatric Migraine Disability Assessment Score in Arabic. The parents of 18 healthy controls also completed the Children's Sleep Habits Questionnaire. Urinary 6-sulphatoxymelatonin levels were determined with the enzyme-linked immunosorbent assay method. There was no significant difference in urinary 6-sulphatoxymelatonin between the migraine and control groups (Z = -0.127, P = .889). There were no significant differences between groups in Children's Sleep Habits Questionnaire subscales or total scores. There were significant correlations between bedtime resistance, parasomnias subscales, and migraine disability. Our findings indicate that nocturnal production of melatonin is not reduced in children with migraine, and sleep disturbances impact the degree of migraine disability.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt maha_korany71@yahoo.com.
authors.forename: Maha K
authors.initials: MK
authors.lastname: Abou-Khadra
authors.affiliation: Department of Neurology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Nirmeen A
authors.initials: NA
authors.lastname: Kishk
authors.affiliation: Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Olfat G
authors.initials: OG
authors.lastname: Shaker
authors.affiliation: Department of Neurology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Amr
authors.initials: A
authors.lastname: Hassan
mesh_terms: D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology; D004185:Disability Evaluation; D005260:Female; D006184:Habits; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008881:Migraine Disorders / Q000150:complications* / Q000652:urine*; D012893:Sleep Wake Disorders / Q000209:etiology*; D013223:Statistics as Topic; D011795:Surveys and Questionnaires
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin
keywords: 6-sulphatoxymelatonin; migraine; sleep