title: Non steroid treatment for eczema: results from a controlled and randomized study.
abstract: OBJECTIVE
  This study assesses the efficacy of a new non steroid anti-inflammatory product in comparison to Hydrocortisone Butyrate 0.1% Cream in healing eczematous dermatitis.
  
  
  METHODS
  A bilateral controlled randomized pilot study was conducted in Italian adults affected by eczema with at least two symmetric lesions at baseline, respectively assigned to a non steroid cream or Hydrocortisone. The severity of lesions was judged through the Global Clinical Score (GCS) and the recovery was defined as a GSC equal to 0. The study investigated: 1) the differences in GCS between four points in time during therapy (baseline, four, eight, twelve weeks), according to medication received; 2) treatment efficacy.
  
  
  RESULTS
  The study showed that time, treatment and interaction between treatment and time were associated with GCS; moreover, lesions treated with Hydrocortisone went better on the whole but the post-hoc analysis showed a significant clinical improving at each point in time only for the non steroid cream. At the end of the study, in the intention to treat analysis, lesions recovered in 76.1% and 40.3% patients treated with Hydrocortisone and with the non steroid cream respectively; in the per protocol population, recovery was achieved in 91.7% and 58.3% of cases.
  
  
  CONCLUSIONS
  According to the results, the non steroid cream has been demonstrated effective in reducing the severity of eczema and may be used with continuing success in the long term treatment of the disease.
authors.affiliation: Institute of Public Health Sacro Cuore Catholic University, Rome, Italy - chiara.dewaure@rm.unicatt.it.
authors.forename: C
authors.initials: C
authors.lastname: De Waure
authors.forename: C
authors.initials: C
authors.lastname: Cadeddu
authors.forename: A
authors.initials: A
authors.lastname: Venditti
authors.forename: A
authors.initials: A
authors.lastname: Barcella
authors.forename: A
authors.initials: A
authors.lastname: Bigardi
authors.forename: S
authors.initials: S
authors.lastname: Masci
authors.forename: G
authors.initials: G
authors.lastname: Virno
authors.forename: A
authors.initials: A
authors.lastname: Cammisa
authors.forename: W
authors.initials: W
authors.lastname: Ricciardi
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004485:Eczema / Q000188:drug therapy*; D004643:Emollients / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D019695:Glycyrrhizic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003879:Dermatologic Agents; D004643:Emollients; C585595:Floderm topical cream; D009824:Ointments; C007975:hydrocortisone-17-butyrate; D019695:Glycyrrhizic Acid; D006854:Hydrocortisone