title: 18F-FDG PET/CT superior to serum CEA in detection of colorectal cancer and its recurrence.
abstract: The aim of this study was to examine whether positron emission tomography (PET)/computed tomography (CT) can detect more cases of colorectal cancer (CRC) than serum carcinoembryonic antigen (CEA), both at initial staging and during surveillance for recurrence. A retrospective review of 639 CRC patients imaged with PET/CT was performed. PET/CT was superior to serum CEA in detecting CRC, identifying 2.5 times as many CRC at initial staging compared to serum CEA and 1.5 times as many CRC recurrences. The current guideline recommendations of utilizing PET/CT only in the context of a rising serum CEA will miss more than one third of all CRC recurrences.
authors.affiliation: Department of Diagnostic Imaging, Cross Cancer Institute, 11560 University Ave NW Edmonton, AB, T6G 1Z2, Canada. Electronic address: makisw79@yahoo.com.
authors.forename: William
authors.initials: W
authors.lastname: Makis
authors.forename: David
authors.initials: D
authors.lastname: Kurzencwyg
authors.forename: Marc
authors.initials: M
authors.lastname: Hickeson
mesh_terms: D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000532:radiotherapy; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D002272:Carcinoembryonic Antigen; D019788:Fluorodeoxyglucose F18
keywords: CEA; Carcinoembryonic antigen; Colorectal cancer; FDG; PET/CT