title: Bleomycin loaded magnetite nanoparticles functionalized by polyacrylic acid as a new antitumoral drug delivery system.
abstract: OBJECTIVE
  To prepare, characterize, and analyze the release behavior of bleomycin-loaded magnetite nanoparticles (BLM-MNPs) coated with polyacrylic acid (PAA) as a new drug delivery system that can be specifically distributed in the tumor site.
  
  
  METHODS
  BLM-MNPs coated with PAA were prepared using a solvothermal approach. The particles were characterized using scanning electron microscope (SEM), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FTIR). The loading and release behaviors of BLM-MNPs were examined by a mathematical formula and in vitro release profile at pH 7.5.
  
  
  RESULTS
  The sphere Fe3O4 nanoparticles with the size of approximately 30 nm exhibit a saturation magnetization of 87 emu/g. The noncoordinated carboxylate groups of PAA confer on the good dispersibility in the aqueous solution and lead to a good loading efficiency of BLM reaching 50% or higher. Approximately 98% of immobilized BLM could be released within 24 h, of which 22.4% was released in the first hour and then the remaining was released slowly and quantitatively in the next 23 hours.
  
  
  CONCLUSIONS
  BLM-MNPs were prepared and characterized successfully. The particles show high saturation magnetization, high drug loading capacity, and favorable release property, which could contribute to the specific delivery and controllable release of BLM, and the BLM-MNPs could be a potential candidate for the development of treating solid tumors.
authors.affiliation: Department of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangdong, Guangzhou 510055, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Zhuang
authors.forename: Jiong
authors.initials: J
authors.lastname: Lin
authors.forename: Jiahong
authors.initials: J
authors.lastname: Lv
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.forename: Jiadong
authors.initials: J
authors.lastname: Sun
mesh_terms: D000042:Absorption; D000180:Acrylic Resins / Q000737:chemistry* / Q000528:radiation effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001761:Bleomycin / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D001761:Bleomycin; C006903:carbopol 940