title: Renal replacement therapy in ADPKD patients: a 25-year survey based on the Catalan registry.
abstract: BACKGROUND
  Some 7-10% of patients on replacement renal therapy (RRT) are receiving it because of autosomal dominant polycystic kidney disease (ADPKD). The age at initiation of RRT is expected to increase over time.
  
  
  METHODS
  Clinical data of 1,586 patients (7.9%) with ADPKD and 18,447 (92.1%) patients with other nephropathies were analysed from 1984 through 2009 (1984-1991, 1992-1999 and 2000-2009).
  
  
  RESULTS
  The age at initiation of RRT remained stable over the three periods in the ADPKD group (56.7 ± 10.9 (mean ± SD) vs 57.5 ± 12.1 vs 57.8 ± 13.3 years), whereas it increased significantly in the non-ADPKD group (from 54.8 ± 16.8 to 63.9 ± 16.3 years, p < 0.001). The ratio of males to females was higher for non-ADPKD than for ADPKD patients (1.6-1.8 vs 1.1-1.2). The prevalence of diabetes was significantly lower in the ADPKD group (6.76% vs 11.89%, p < 0.001), as were most of the co-morbidities studied, with the exception of hypertension. The survival rate of the ADPKD patients on RRT was higher than that of the non-ADPKD patients (p < 0.001).
  
  
  CONCLUSIONS
  Over time neither changes in age nor alterations in male to female ratio have occurred among ADPKD patients who have started RRT, probably because of the impact of unmodifiable genetic factors in the absence of a specific treatment.
authors.affiliation: Inherited Renal Diseases, Nephrology Department, Fundacio Puigvert, IIB Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain. rtorra@fundacio-puigvert.es.
authors.forename: Víctor
authors.initials: V
authors.lastname: Martínez
authors.forename: Jordi
authors.initials: J
authors.lastname: Comas
authors.forename: Emma
authors.initials: E
authors.lastname: Arcos
authors.forename: Joan Manel
authors.initials: JM
authors.lastname: Díaz
authors.forename: Salomé
authors.initials: S
authors.lastname: Muray
authors.forename: Juan
authors.initials: J
authors.lastname: Cabezuelo
authors.forename: José
authors.initials: J
authors.lastname: Ballarín
authors.forename: Elisabet
authors.initials: E
authors.lastname: Ars
authors.forename: Roser
authors.initials: R
authors.lastname: Torra
mesh_terms: D017677:Age Distribution; D015897:Comorbidity; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D006973:Hypertension / Q000401:mortality*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000401:mortality* / Q000534:rehabilitation*; D015995:Prevalence; D012042:Registries; D017582:Renal Replacement Therapy / Q000401:mortality*; D012307:Risk Factors; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate; D016896:Treatment Outcome