title: Cobalt-catalyzed asymmetric addition of silylacetylenes to 1,1-disubstituted allenes.
abstract: The asymmetric addition of silylacetylenes to 1,1-disubstituted allenes proceeded in the presence of a cobalt/chiral bisphosphine ligand to give the corresponding enynes with high enantioselectivity. The results of deuterium-labeling experiments indicated that a hydrogen atom at the chiral center is originated from the terminal alkyne, and they were in good agreement with the proposed catalytic cycle where enantioselectivity is determined by the reaction of the proposed π-allylcobalt intermediate with the terminal alkyne.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo, Kyoto 606-8502, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sawano
authors.forename: Keiyu
authors.initials: K
authors.lastname: Ou
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nishimura
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000466:Alkadienes; D000480:Alkynes; D009942:Organometallic Compounds; D003035:Cobalt