title: Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan.
abstract: Serial antibacterial furanoditerpenes caesanines A-D (1-4), possessing a cassane-type diterpenoid skeleton with an unusual N bridge between C-19/C-20, were identified from a Chinese herb Caesalpinia sappan Linn. In addition, caesanine D (4) showed the first class of dicassane diterpenoid ethers. Their structures were determined by different spectroscopic methods and ECD calculation. Caesanines A and B exhibited strong activities against MRSA suggesting a promising entry point for the development of anti-infective drugs.
authors.affiliation: Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology Chinese Academy of Sciences , Beijing, 100080, China, Department of Natural Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China, Department of Pharmacognosy, College of Pharmacy, King Saud University , Riyadh 11451, Kingdom of Saudi Arabia, Department of Pharmacognosy, Faculty of Pharmacy, Assiut University , Assiut 71526, Egypt, Department of Medicinal Chemistry, Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China, and University of Chinese Academy of Sciences , Beijing, 100049, China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Wael M
authors.initials: WM
authors.lastname: Abdel-Mageed
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Liu
authors.forename: Pei
authors.initials: P
authors.lastname: Huang
authors.forename: Wenni
authors.initials: W
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Xueting
authors.initials: X
authors.lastname: Liu
authors.forename: Jingyu
authors.initials: J
authors.lastname: Liang
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; C586600:caesanine D