title: Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association.
abstract: Long noncoding RNAs (lncRNAs) play crucial roles during cancer occurrence and progression. The pseudogene-expressed lncRNA is one major type of lncRNA family. However, their association with cancers is largely unknown. In this study, we focused on small ubiquitin-like modifier (SUMO) 1 pseudogene 3, SUMO1P3. Gastric cancer tissues and adjacent nontumor tissues were collected from 96 patients with gastric cancer. The SUMO1P3 levels were detected by quantitative reverse transcription-polymerase chain reaction. Then, the association between the level of SUMO1P3 in gastric cancer tissues and the clinicopathological features of patients with gastric cancer was further analyzed. A receiver operating characteristic curve was constructed for differentiating patients with gastric cancer from patients with benign gastric diseases. The results showed that SUMO1P3 was significantly up-regulated in gastric cancer tissues compared with paired-adjacent nontumorous tissues (p < 0.01). Its expression level was significantly correlated with tumor size (p = 0.003), differentiation (p = 0.002), lymphatic metastasis (p = 0.001), and invasion (p = 0.039). The area under the ROC curve of SUMO1P3 was up to 0.666. These results indicated, for the first time, that pseudogene-expressed lncRNA SUMO1P3 may be a potential biomarker in the diagnosis of gastric cancer.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, 818 Fenghua Road, Ningbo, 315211, China.
authors.forename: Danyi
authors.initials: D
authors.lastname: Mei
authors.forename: Haojun
authors.initials: H
authors.lastname: Song
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Yichao
authors.initials: Y
authors.lastname: Lou
authors.forename: Weiliang
authors.initials: W
authors.lastname: Sun
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Ding
authors.forename: Junming
authors.initials: J
authors.lastname: Guo
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D011544:Pseudogenes / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics; D025842:SUMO-1 Protein / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*; D015854:Up-Regulation / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding; D025842:SUMO-1 Protein; C495501:SUMO1 protein, human