title: Primary testicular non-Hodgkin lymphoma. a 10-year Tunisian single-institute experience.
abstract: BACKGROUND
  Primary testicular non-Hodgkin lymphoma (NHL) is an uncommon extra nodal presentation, accounting for 1% of all NHL and 1 to 9% of testicular neoplasms. Median age at time of presentation is 60 years old. Anthracycline based chemotherapies are most frequently used.
  
  
  OBJECTIVE
  To analyze baseline characteristics, treatment modalities and survival of six cases of primary testicular non-Hodgkin lymphoma.
  
  
  METHODS
  We screened 46 testicular neoplasm cases registered from January 1999 to January 2009 and found six primary testicular lymphoma patients. These six cases were analyzed for baseline clinical features, investigations, treatment and outcome variables.
  
  
  RESULTS
  Median age was 50 years old and median duration of symptoms was 4 months. All patients had testicular swelling. Four patients had abdominal lymphadenopathy. Most patients had diffuse large B-cell histology. All patients underwent high inguinal orchidectomy and five were treated with anthracycline based chemotherapy. Four patients completed therapy and one of them relapsed two years later.
  
  
  CONCLUSIONS
  Primary testicular NHL is an uncommon entity and with current combined modality treatment, the outcome may be as good as nodal NHL.
authors.forename: Walid
authors.initials: W
authors.lastname: Kerkeni
authors.forename: Mohamed Slim
authors.initials: MS
authors.lastname: Selmi
authors.forename: Abderrazak
authors.initials: A
authors.lastname: Bouzouita
authors.forename: Nadia
authors.initials: N
authors.lastname: Znaidi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Cherif
authors.forename: Amine
authors.initials: A
authors.lastname: Derouiche
authors.forename: Rachida
authors.initials: R
authors.lastname: Zermani
authors.forename: Mohamed Riadh
authors.initials: MR
authors.lastname: Ben Slama
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chebil
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D012189:Retrospective Studies; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D014416:Tunisia / Q000453:epidemiology
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic