title: [Alterations in orbitofrontal cortex functional connectivity and decision making deficits in heroin-dependent individuals].
abstract: OBJECTIVE
  To investigate the changes in orbitofrontal cortex (OFC) functional connectivity and its association with decision-making deficits in chronic heroin-dependent individuals (HDIs) and explore the neural mechanisms of heroin addiction and relapse.
  
  
  METHODS
  Fourteen male chronic HDIs and 14 healthy subjects matched for age, education, and nicotine consumption participated in this study. Resting state functional magnetic resonance imaging (fMRI) was performed using a 1.5 T MR scanner. Functional connectivity of the OFC and the rest of the brain were calculated using REST software. Voxel-based analysis of the functional connectivity maps between the control and HDI groups was performed with two-sample t test. The Iowa gambling task (IGT) was used to assess the participants' decision making during uncertainty.
  
  
  RESULTS
  Compared with the control group, the HDIs showed significantly decreased functional connectivity of the OFC and the right inferior parietal lobule (rIPL) (t=3.5, P<0.05). A significant negative correlation was noted between the functional connectivity of the OFC-rIPL and performance level at the IGT.
  
  
  CONCLUSIONS
  The OFC-rIPL functional connectivity is significantly disrupted in HDIs, which may be the neural basis for decision-making deficits.
authors.affiliation: Department of Medical Imaging, Guangdong Provincial Second People's Hospital, Guangzhou 510317, China. E-mail: qiuyw1201@gmail.com.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Qiu
authors.forename: Guihua
authors.initials: G
authors.lastname: Jiang
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Su
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Ma
authors.forename: Liming
authors.initials: L
authors.lastname: Li
authors.forename: Junzhang
authors.initials: J
authors.lastname: Tian
authors.forename: Xuelin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003657:Decision Making; D005625:Frontal Lobe / Q000503:physiopathology*; D006556:Heroin Dependence / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male