title: Nucleosides, a valuable chemical marker for quality control in traditional Chinese medicine Cordyceps.
abstract: Cordyceps, a well-known traditional Chinese medicine, is an endoparasitic and/or symbiotic macrofungus in the body of insect and other arthropod, and has received increasing attention worldwide due to its rarity and outstanding curative effects for different diseases. Recent years, however, the counterfeits and mimics of Cordyceps are frequently found in markets because of its scarce in nature and high in price. Therefore, quality control of Cordyceps and its bioproducts is very important to ensure their safety and efficacy. Nucleoside is recognized as a major active component of Cordyceps, and even is used as chemical marker for quality control of Cordyceps. In this present review, recent studies and associated patents, with regard to the chemical marker nucleosides for quality control of Cordyceps and its bioproducts, including nucleoside components, pharmacological activities, and analytical methods were reviewed and discussed thereof. Also, developing trends in the field have been appraised.
authors.affiliation: Division of Applied Mycology and Biochemical Pharmacy, Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical College, 149 Dalian Road, Zunyi 563000, China. jianhuixiao@yahoo.com
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Xiao
authors.forename: Ying
authors.initials: Y
authors.lastname: Qi
authors.forename: Qing
authors.initials: Q
authors.lastname: Xiong
mesh_terms: D015415:Biomarkers / Q000032:analysis; D032661:Cordyceps; D008516:Medicine, Chinese Traditional / Q000592:standards*; D009705:Nucleosides / Q000032:analysis*; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000592:standards*; D011786:Quality Control
chemical_list: D015415:Biomarkers; D009705:Nucleosides; D004364:Pharmaceutical Preparations