title: Influences of genetic variation of endothelin-1 gene on effects of 16-week combined exercise on clinical and physical parameters in middle-aged women.
abstract: BACKGROUND AND OBJECTIVE. In this study, we attempted to determine whether the C/T polymorphism of the ET-1 gene was significantly associated with changes in several clinical characteristics after the 16-week combined exercise program in overweight middle-aged women. MATERIAL AND METHODS. The C/T polymorphism of the ET-1 gene was assayed using polymerase chain reaction, i.e., the TaqI restriction fragment length polymorphism method. RESULTS. The genetic variation in the ET-1 gene showed a significant association with the serum LDL cholesterol level as well as several parameters of physical fitness, including muscular endurance and power of the participants (P<0.05). In addition, this genetic variation showed a significant association with changes in muscular strength of the participants after the 16-week combined exercise program (P<0.05). CONCLUSIONS. Our data suggest that the C/T substitution on intron 4 of the ET-1 gene may be a useful genetic marker influencing muscular strength through a gene-exercise interaction and is associated with an interindividual difference of cardiovascular risk factors and parameters of physical fitness.
authors.affiliation: Department of Leisure and Sports, Sahmyook University, Republic of Korea.
authors.forename: Jaekoo
authors.initials: J
authors.lastname: Lee
authors.forename: Ingeun
authors.initials: I
authors.lastname: Jung
authors.forename: Jaewoong
authors.initials: J
authors.lastname: Kim
authors.forename: Yoohyun
authors.initials: Y
authors.lastname: Park
authors.forename: Byungyong
authors.initials: B
authors.lastname: Kang
mesh_terms: D044466:Asian People / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D019332:Endothelin-1 / Q000235:genetics*; D015444:Exercise; D005260:Female; D059647:Gene-Environment Interaction; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D053580:Muscle Strength / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D019332:Endothelin-1