title: Relation of estimated glomerular filtration rate to the presence of coronary plaque and obstructive coronary artery disease in a zero or low coronary artery calcium score.
abstract: OBJECTIVE
  Although renal dysfunction is associated with the presence of atherosclerosis, little is known about the relationship between reduced estimated glomerular filtration rate (eGFR) and the presence of atherosclerosis detected by coronary computed tomographic angiography (CCTA). This study evaluated the relation of eGFR to the presence of coronary plaque and obstructive coronary artery disease (CAD) in patients with a zero or low coronary artery calcium score (CACS).
  
  
  METHODS
  Coronary artery calcium scoring and CCTA were performed with CT scanners. Serum creatinine was measured before CCTA, and GFR was estimated. A total of 720 patients with a CACS ≤ 10 were enrolled.
  
  
  RESULTS
  Coronary plaque was detected in 118 patients. Of the 118 patients, 36 had a diagnosis of obstructive CAD. The multiple-adjusted odds ratios of presenting with coronary plaque and obstructive CAD were 1.82 (95% CI 1.06-3.12, p = 0.030) and 1.79 (95% CI 0.71-4.49, p = 0.217) for the lowest tertile of eGFR compared with the highest tertile, respectively.
  
  
  CONCLUSIONS
  Lower eGFR levels were associated with the presence of coronary plaque in patients with a zero or low CACS. However, the association between eGFR and the presence of obstructive CAD was not statistically significant.
authors.affiliation: Department of Cardiology, Sumitomo Hospital, Osaka, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ueda
authors.forename: Satoki
authors.initials: S
authors.lastname: Tomoyama
authors.forename: Masami
authors.initials: M
authors.lastname: Miyawaki
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Mitsusada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yasuga
authors.forename: Hisatoyo
authors.initials: H
authors.lastname: Hiraoka
mesh_terms: D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology*; D023921:Coronary Stenosis / Q000473:pathology / Q000503:physiopathology*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology; D051437:Renal Insufficiency / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000473:pathology / Q000503:physiopathology
chemical_list: D003404:Creatinine