title: Microwave-accelerated Pd-catalyzed desulfitative direct C2-arylation of free (NH)-indoles with arylsulfinic acids.
abstract: The rapid and efficient direct C2-arylation of free (NH)-indoles with arylsulfinic acids proceeded through a microwave-accelerated palladium-catalyzed desulfitation reaction. By using PdCl2 as a catalyst, silver acetate as an oxidant, and H2SO4 as an additive, arylsulfinic acids with both electron-donating and electron-withdrawing groups underwent desulfitative coupling with an array of free (NH)-indoles, thereby selectively providing C2-arylindoles in good yields.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000 (P. R. China), Fax: (+86) 561-3090518.
authors.forename: Tao
authors.initials: T
authors.lastname: Miao
authors.forename: Pinhua
authors.initials: P
authors.lastname: Li
authors.forename: Guan-Wu
authors.initials: GW
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D007211:Indoles; D013441:Sulfinic Acids; D010165:Palladium; C008756:palladium chloride
keywords: arylation; desulfitation; indoles; microwave chemistry; palladium