title: The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference.
abstract: Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
authors.affiliation: School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
authors.forename: Edwige
authors.initials: E
authors.lastname: Rancès
authors.forename: Travis K
authors.initials: TK
authors.lastname: Johnson
authors.forename: Jean
authors.initials: J
authors.lastname: Popovici
authors.forename: Iñaki
authors.initials: I
authors.lastname: Iturbe-Ormaetxe
authors.forename: Tasnim
authors.initials: T
authors.lastname: Zakir
authors.forename: Coral G
authors.initials: CG
authors.lastname: Warr
authors.forename: Scott L
authors.initials: SL
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D003716:Dengue Virus / Q000254:growth & development*; D029721:Drosophila Proteins / Q000235:genetics / Q000276:immunology*; D004331:Drosophila melanogaster / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D005260:Female; D007113:Immunity, Innate; D056265:Microbial Interactions; D009154:Mutation; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology*; D020577:Wolbachia / Q000254:growth & development*
chemical_list: D029721:Drosophila Proteins; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C439909:imd protein, Drosophila