title: Cu(2+)-responsive bimodal (optical/MRI) contrast agent for cellular imaging.
abstract: A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu(2+) ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.
authors.affiliation: Department of Chemistry, Korea University , Seoul, 136-704, South Korea, Division of MR Research, Korea Basic Science Institute , Cheongwon 363-883, South Korea, and Graduate School of Analytical Science and Technology, Chungnam National University , Daejeon 305-764, South Korea.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Jang
authors.forename: Sankarprasad
authors.initials: S
authors.lastname: Bhuniya
authors.forename: Jongeun
authors.initials: J
authors.lastname: Kang
authors.forename: Areum
authors.initials: A
authors.lastname: Yeom
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Hong
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes; D014867:Water; D003300:Copper