title: T helper cytokines in dry eye disease.
abstract: Dry eye is an inflammatory disease that results from activation of innate inflammatory pathways in resident ocular surface cells, as well as cytokines produced by recruited T helper (Th) cells. Cytokines produced by the infiltrating Th cells alter the normal cytokine balance on the ocular surface and cause ocular surface epithelial pathology. Changes in levels of Th cytokines on the ocular surface have been measured in dry eye and the biological effects of these cytokines have been documented in experimental culture and mouse model systems. The Th2 cytokine IL-13 has a homeostatic role in promoting goblet cell differentiation. In contrast, The Th1 cytokine IFN-γ antagonizes IL-13 and promotes apoptosis and squamous metaplasia of the ocular surface epithelia. The Th17 cytokine, IL-17 promotes corneal epithelial barrier disruption. The ocular surface epithelium expresses receptors to all of these Th cytokines. Therapies that maintain normal IL-13 signaling, or suppress IFN-γ and IL-17 have potential for treating the ocular surface disease of dry eye.
authors.affiliation: Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin NC205, Houston, TX 77030, USA. Electronic address: stevenp@bcm.edu.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Pflugfelder
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Corrales
authors.forename: Cintia S
authors.initials: CS
authors.lastname: de Paiva
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D015352:Dry Eye Syndromes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051379:Mice; D015398:Signal Transduction / Q000502:physiology; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*
chemical_list: D016207:Cytokines
keywords: T cell; cytokine; dry eye; inflammation; interferon gamma; interleukin 13; interleukin 17; tear dysfunction