title: [Acute myeloid leukemia possibly originating from the same clone of testicular germ cell tumor].
abstract: This report describes a 30-year-old man with a testicular germ cell tumor, which later developed into acute myeloid leukemia (AML) with a common chromosomal abnormality. Testicular germ cell tumors had developed at the age of 26. He was successfully treated with surgery followed by chemotherapy.Four years after the onset of the germ cell tumor, he developed pancytopenia with elevated serum LDH. More than 95% of the bone marrow was occupied by blastic cells. These cells were CD13+, CD34+ but CD45- and MPO-. Amplification of the short arm of chromosome 12 was recognized by fluorescence in situ hybridization using the blastic cells in the bone marrow and the previous testicular tumor specimen. Because testicular germ cell tumor recurrence and other malignant tumors could be ruled out pathologically, he was diagnosed as having AML.Allogeneic stem cell transplantation from a HLA-matched sibling donor was performed after chemotherapy. As of 19 months after the transplantation, recurrence of neither AML nor testicular tumors has been observed. Because the same genetic abnormality was observed in the testicular germ cell tumor and AML in this case, the possibility of AML having a common origin with the testicular germ cell tumor is indicated.
authors.affiliation: Department of Hematology, University of Tsukuba.
authors.forename: Takuya
authors.initials: T
authors.lastname: Suyama
authors.forename: Naoshi
authors.initials: N
authors.lastname: Obara
authors.forename: Koji
authors.initials: K
authors.lastname: Kawai
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamada
authors.forename: Manabu
authors.initials: M
authors.lastname: Kusakabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Kurita
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishikii
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Kazumi
authors.initials: K
authors.lastname: Suzukawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chiba
mesh_terms: D000328:Adult; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000473:pathology*; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology*