title: Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line.
abstract: Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Mai Thanh Thi
authors.initials: MTT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Thy Anh
authors.initials: TA
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Nhi Y Thi
authors.initials: NYT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Dao Anh Thi
authors.initials: DAT
authors.lastname: Phan
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Phuoc Ho
authors.initials: PH
authors.lastname: Thi
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Trong Huu Phan
authors.initials: THP
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Phu Hoang
authors.initials: PH
authors.lastname: Dang
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Viet Nam.
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C000588648:tomocinon
keywords: Antiausterity strategy; Anticancer drug discovery; Caesalpinia sappan; Cleistanthane diterpene; Nutrient starvation; PANC-1