title: Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases.
abstract: Apolipoprotein E (apoE), one of the major plasma lipoproteins, plays a major role in the transport and metabolism of lipids by acting as a ligand. apoE gene contains three potential alleles: ϵ2, ϵ3 and ϵ4, forming six genotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Association between apoE gene polymorphism and triglyceride (TG) is still controversial. There was not any meta-analysis to explore the association of apoE gene polymorphism with triglyceride level, and this meta-analysis was performed to evaluate the association between apoE gene polymorphism and triglyceride in patients with renal diseases. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Twenty-four articles were identified for the analysis of association between apoE gene polymorphism and triglyceride level. Subjects with E2E3 or E3E4 had a higher TG than those with E3E3. Subjects with ϵ4 had a higher TG than those with ϵ3. Subjects with ϵ2 had a slightly higher TG than those with ϵ3, although there was no statistical difference. Interestingly, subjects with ϵ4 had a much higher TG than those with ϵ2. In conclusion, E2E3, E3E4 or ϵ4 was associated with higher level of TG. However, more studies should be performed in the future.
authors.affiliation: Department of Pediatric Surgery, The First Affiliated Hospital of GuangXi Medical University , NanNing , China.
authors.forename: Chun-Qiang
authors.initials: CQ
authors.lastname: Dong
authors.forename: Yi-Ge
authors.initials: YG
authors.lastname: Luo
authors.forename: Kun
authors.initials: K
authors.lastname: Dong
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Ti-Quan
authors.initials: TQ
authors.lastname: Yang
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D011110:Polymorphism, Genetic; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000235:genetics*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001057:Apolipoproteins E; D014280:Triglycerides