title: Redox-responsive, core-cross-linked micelles capable of on-demand, concurrent drug release and structure disassembly.
abstract: We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepared via coprecipitation of disulfide-containing CPT-poly(tyrosine(alkynyl)-OCA) conjugate and monomethoxy poly(ethylene glycol)-b-poly(tyrosine(alkynyl)-OCA), followed by cross-linking of the micellar core via azide-alkyne click chemistry. CCL micelles exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in reduction circumstance, resulting in burst release of CPT. These redox-responsive CCL micelles showed enhanced cytotoxicity against human breast cancer cells in vitro.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign , 1304 West Green Street, Urbana, Illinois 61801, United States.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Chunlai
authors.initials: C
authors.lastname: Tu
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Song
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002166:Camptothecin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D057930:Click Chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004220:Disulfides / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D004220:Disulfides; D008823:Micelles; D002166:Camptothecin