title: Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a Western diet.
abstract: The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.
authors.affiliation: From the Departments of Biochemistry.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Cheng
authors.forename: Shuang
authors.initials: S
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Chu
authors.forename: Parvin
authors.initials: P
authors.lastname: Hakimi
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Berger
authors.forename: Richard W
authors.initials: RW
authors.lastname: Hanson
authors.forename: Hung-Ying
authors.initials: HY
authors.lastname: Kao
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D054392:Adipokines / Q000235:genetics; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D001831:Body Temperature / Q000235:genetics; D018955:CD36 Antigens / Q000235:genetics; D004032:Diet / Q000009:adverse effects; D004734:Energy Metabolism / Q000235:genetics*; D005227:Fatty Acids / Q000378:metabolism; D015870:Gene Expression; D051275:Glucose Transporter Type 4 / Q000235:genetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D057507:Mice, 129 Strain; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000378:metabolism; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics*; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D010084:Oxidation-Reduction; D000071156:Promyelocytic Leukemia Protein; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000172:deficiency / Q000235:genetics*
chemical_list: D054392:Adipokines; D018955:CD36 Antigens; D005227:Fatty Acids; D051275:Glucose Transporter Type 4; D009687:Nuclear Proteins; C513293:Pml protein, mouse; D000071156:Promyelocytic Leukemia Protein; C495693:Slc2a4 protein, mouse; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D055372:AMP-Activated Protein Kinases
keywords: AMP-activated Kinase (AMPK); Fatty Acid Metabolism; Mitochondrial Metabolism; Nuclear Receptors; Obesity; PML