title: Single dose of green tea extract decreases lipid digestion and absorption from a test meal in humans.
abstract: OBJECTIVE
  Green tea is known worldwide for its high content of polyphenolic compounds and multifactorial beneficial effects on human health. The role of green tea as an inhibitor of lipid hydrolysis is widely discussed. The aim of the study was to assess the influence of green tea extract on lipid digestion and absorption.
  
  
  METHODS
  The study comprised 32 healthy volunteers aged 23 to 30 years with normal exocrine pancreatic function. In all subjects (13)C-labelled mixed triglyceride breath test was performed twice with and without green tea extract ingestion. Cumulative percentage dose recovery was considered to reflect digestion and absorption of lipids. Values are expressed as medians and 1st-3rd quartile distribution.
  
  
  RESULTS
  In all subjects, cumulative percentage dose recovery values were normal in a placebo test (36.8% <30.1-43.3%>). These results were significantly higher (p=0.021) than those obtained in green tea extract test (28.8% <23.1-37.2%>). Results of six tests with GTE were abnormal.
  
  
  CONCLUSIONS
  Single dose of green tea extract taken with a test meal decreases lipid digestion and absorption in humans.
authors.affiliation: Department of Pediatric Gastroenterology & Metabolic Diseases, Poznan University of Medical Sciences and Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznań, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Walkowiak
authors.forename: Joanna
authors.initials: J
authors.lastname: Bajerska
authors.forename: Angelika
authors.initials: A
authors.lastname: Kargulewicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Lisowska
authors.forename: Gwidon
authors.initials: G
authors.lastname: Siedlerski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szczapa
authors.forename: Natalia
authors.initials: N
authors.lastname: Kobelska-Dubiel
authors.forename: Marian
authors.initials: M
authors.lastname: Grzymisławski
mesh_terms: D000328:Adult; D001944:Breath Tests; D002247:Carbon Isotopes; D002392:Catechin / Q000032:analysis; D004063:Digestion / Q000187:drug effects* / Q000502:physiology; D064368:Healthy Volunteers; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D062407:Meals; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000008:administration & dosage
chemical_list: D002247:Carbon Isotopes; D010936:Plant Extracts; D013662:Tea; D014280:Triglycerides; D002392:Catechin