title: Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY).
abstract: OBJECTIVE
  This study compared the effects of telmisartan and losartan on nonalcoholic fatty liver disease (NAFLD) and biochemical markers of insulin resistance in hypertensive NAFLD patients with type 2 diabetes mellitus.
  
  
  METHODS
  This was a randomized, open-label, parallel-group comparison of therapy with telmisartan or losartan. Nineteen hypertensive NAFLD patients with type 2 diabetes were randomly assigned to receive telmisartan at a dose of 40 mg once a day (n = 12) [DOSAGE ERROR CORRECTED] or losartan at a dose of 50 mg once a day (n = 7) for 12 months.
  
  
  RESULTS
  The telmisartan group showed a significant decline in serum free fatty acid (FFA) level (from 0.87 ± 0.26 to 0.59 ± 0.22 mEq/L (mean ± SD), P = 0.005) and a significant increase in L/S ratio (P = 0.049) evaluated by CT scan, while these parameters were not changed in the losartan group.
  
  
  CONCLUSIONS
  Although there was no significant difference in improvement in liver enzymes with telmisartan and losartan treatment in hypertensive NAFLD patients with type 2 diabetes after 12 months, it is suggested that telmisartan may exert beneficial effects by improving fatty liver.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Hirata
authors.forename: Kengo
authors.initials: K
authors.lastname: Tomita
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kawai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirose
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Ebinuma
authors.forename: Junichiro
authors.initials: J
authors.lastname: Irie
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ojiro
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi