title: Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, fromBurkholderia thailandensisE264.
abstract: Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (1), B (2) and C (3), were discovered from the culture broth ofBurkholderia thailandensisE264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (4), E (5) and F (6), respectively. Enzyme assays showed that1-6are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Milwaukee, PO Box 413, Milwaukee, WI 53201, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Creston J
authors.initials: CJ
authors.lastname: Flemming
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Cheng