title: Detection of complete dihydropyrimidine dehydrogenase deficiency in a Tunisian family using a simple phenotypic test.
authors.affiliation: Metabolic Biophysics and Applied Toxicology Laboratory, Department of Biophysics, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Arij
authors.initials: A
authors.lastname: Mani
authors.forename: Manel
authors.initials: M
authors.lastname: Nouira
authors.forename: Slim Ben
authors.initials: SB
authors.lastname: Ahmed
authors.forename: Saad
authors.initials: S
authors.lastname: Saguem
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D054067:Dihydropyrimidine Dehydrogenase Deficiency / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D005190:Family; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D010641:Phenotype; D014416:Tunisia; D014498:Uracil / Q000031:analogs & derivatives* / Q000097:blood*
chemical_list: D000964:Antimetabolites, Antineoplastic; C007419:dihydrouracil; D014498:Uracil; D005472:Fluorouracil