title: Interaction with the Yes-associated protein (YAP) allows TEAD1 to positively regulate NAIP expression.
abstract: Although the expression of the neuronal apoptosis inhibitory protein (NAIP) gene is considered involved in apoptosis suppression as well as in inflammatory response, the molecular basis of the NAIP gene expression is poorly understood. Here we show that the TEA domain protein 1 (TEAD1) is able to positively activate the transcription of NAIP. We further demonstrate that this regulation is mediated by the presence of the endogenous Yes associated protein (YAP) cofactor, and requires the interaction with YAP. We finally identified an intronic region of the NAIP gene responding to TEAD1/YAP activity, suggesting that regulation of NAIP by TEAD1/YAP is at the transcriptional level.
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Equipe de Génétique Moléculaire de la Différenciation, IJM, UMR 7592 CNRS, Paris, France. Electronic address: alm14@nyu.edu.
authors.forename: André
authors.initials: A
authors.lastname: Landin Malt
authors.forename: Adrien
authors.initials: A
authors.lastname: Georges
authors.forename: Joël
authors.initials: J
authors.lastname: Silber
authors.forename: Alain
authors.initials: A
authors.lastname: Zider
authors.forename: Domenico
authors.initials: D
authors.lastname: Flagiello
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D001483:Base Sequence; D045744:Cell Line, Tumor; D004247:DNA; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000235:genetics*; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology; D010750:Phosphoproteins / Q000378:metabolism*; D011485:Protein Binding; D000091262:TEA Domain Transcription Factors; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D014158:Transcription, Genetic; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; C496800:NAIP protein, human; D051616:Neuronal Apoptosis-Inhibitory Protein; D009687:Nuclear Proteins; D010750:Phosphoproteins; D000091262:TEA Domain Transcription Factors; C057182:TEAD1 protein, human; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D004247:DNA
keywords: Hippo pathway; IAP; LATS; MST; NAIP; TEA domain; TEAD; TEAD1; YAP; Yes-associated protein; Yki; Yorkie; inhibitor of apoptosis protein; large tumour suppressor; mammalian Ste20-like protein kinase; neuronal apoptosis-inhibitory protein