title: Paraneoplastic focal segmental glomerulosclerosis in a patient with lung adenocarcinoma.
abstract: Focal segmental glomerulosclerosis (FSGS) is extremely rare among paraneoplastic nephrotic syndromes. We herein report a case of lung adenocarcinoma with nephrotic syndrome caused by paraneoplastic FSGS. A 68-year-old man visited our hospital for an evaluation of a right hilar mass on chest radiography and supraclavicular lymphadenopathy. Because an aspiration biopsy of the supraclavicular lymph node revealed adenocarcinoma, the patient was diagnosed with lung adenocarcinoma. He also had nephrotic syndrome, and the pathological findings of the renal biopsy demonstrated FSGS. Standard-dose carboplatin-containing chemotherapy led to a partial response for lung cancer and improved the patient's nephrotic syndrome without causing any adverse renal effects.
authors.affiliation: Department of Internal Medicine, Kagawa University, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Tadokoro
authors.forename: Tomoya
authors.initials: T
authors.lastname: Ishii
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahama
authors.forename: Naoki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Koshiro
authors.initials: K
authors.lastname: Takano
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kanaji
authors.forename: Osamu
authors.initials: O
authors.lastname: Imataki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Dobashi
authors.forename: Shuji
authors.initials: S
authors.lastname: Bandoh
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis*; D008297:Male