title: Polybrominated diphenyl ethers (PBDEs) in breast milk of Korea in 2011: current contamination, time course variation, influencing factors and health risks.
abstract: Breast milk is a valuable biological specimen to assess maternal and infant exposure to polybrominated diphenyl ethers (PBDEs). In this study, 208 breast milk samples were collected from 89 participants during lactation period, at <7, 15, 30, and 90 days postpartum, in four cities in Korea, and were determined for 19 PBDE congeners. The total PBDE concentrations (ΣPBDE) ranged from 0.23 to 68.4 (mean: 2.73) ng/g lipid weight, and were within the ranges reported for European and Asian countries. Within a month of lactation after delivery, no significant changes were found in the PBDE concentrations. The predominance of BDE 153 rather than BDE 47 was found in the most samples that BDE 153 was detected, and was likely to be associated with stepwise debromination of BDE 209. No associations were found between PBDE concentrations in breast milk and demographic parameters, except for ΣPBDE with maternal age and delivery mode. Certain types of diet such as corn, seafood and nut correlated significantly with PBDE levels in breast milk. The estimated daily intakes of ΣPBDE for breast-feeding infants were lower than the guidelines proposed by the US EPA, indicating limited health risk from PBDEs through breast feeding.
authors.affiliation: College of Science and Technology, Hanyang University, Ansan, Kyeonggi-do 426-791, Republic of Korea.
authors.forename: Sunggyu
authors.initials: S
authors.lastname: Lee
authors.forename: Sunmi
authors.initials: S
authors.lastname: Kim
authors.forename: Eunkyo
authors.initials: E
authors.lastname: Kim
authors.forename: In-Seok
authors.initials: IS
authors.lastname: Lee
authors.forename: Gyuyeon
authors.initials: G
authors.lastname: Choi
authors.forename: Hai-Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jeongim
authors.initials: J
authors.lastname: Park
authors.forename: Jeong
authors.initials: J
authors.lastname: Jae Lee
authors.forename: Sooran
authors.initials: S
authors.lastname: Choi
authors.forename: Su
authors.initials: S
authors.lastname: Young Kim
authors.forename: Suungjoo
authors.initials: S
authors.lastname: Kim
authors.forename: Sungkyoon
authors.initials: S
authors.lastname: Kim
authors.forename: Kyungho
authors.initials: K
authors.lastname: Choi
authors.forename: Hyo-Bang
authors.initials: HB
authors.lastname: Moon
mesh_terms: D000328:Adult; D004032:Diet / Q000706:statistics & numerical data; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy; D056910:Republic of Korea; D018570:Risk Assessment; D013997:Time Factors; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers
keywords: Association; Debromination; Estimated daily intake; Health risk; PBDE