title: Resolution of a left ventricular thrombus by the thrombolytic action of dabigatran.
abstract: A 77-year-old man was referred to our cardiovascular department for detailed examination after abnormal electrocardiography findings were obtained during a preoperative cataract surgery workup. Ultrasound echocardiography (UCG) and computed tomography (CT) revealed evidence of previous myocardial infarction with anteroseptal akinesis and a left ventricular (LV) thrombus (14 × 12 mm). Dabigatran (220 mg/day) was prescribed as an outpatient treatment, and the disappearance of the LV thrombus was confirmed by UCG and CT 27 days after dabigatran initiation. No thromboembolism occurred between treatment initiation and thrombus resolution. Our results indicate that dabigatran has thrombolytic action on an acute pre-existing intracardiac thrombus.
authors.affiliation: Division of Cardiology, Saga Prefectural Hospital Koseikan, 1-12-9, Mizugae, Saga city, 840-8571, Japan, sqopacificsouthern1978@yahoo.co.jp.
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Nagamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiomi
authors.forename: Taku
authors.initials: T
authors.lastname: Matsuura
authors.forename: Arihide
authors.initials: A
authors.lastname: Okahara
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takegami
authors.forename: Daigo
authors.initials: D
authors.lastname: Mine
authors.forename: Takaharu
authors.initials: T
authors.lastname: Shirahama
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Koga
authors.forename: Keiki
authors.initials: K
authors.lastname: Yoshida
authors.forename: Kenji
authors.initials: K
authors.lastname: Sadamatsu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hayashida
mesh_terms: D000368:Aged; D001562:Benzimidazoles / Q000627:therapeutic use*; D000069604:Dabigatran; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D011237:Predictive Value of Tests; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D001562:Benzimidazoles; D005343:Fibrinolytic Agents; D015091:beta-Alanine; D000069604:Dabigatran