title: Bacillus Calmette-Guérin treatment of urothelial carcinoma arising in the ileal neobladder after radical cystectomy.
abstract: In January 2005, a 66-year-old man underwent radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. A total of 3 years after the cystectomy, left-side ureteral cancer was diagnosed, and a nephroureterectomy was carried out in May 2008. In October 2011, he complained of asymptomatic macroscopic hematuria. We detected multiple papillary pedunculated and broad-based tumors in the left side and the dome of the neobladder. The patient underwent transurethral resection of the bladder tumor, and a pathological diagnosis of high-grade pTa urothelial carcinoma was made. A total of 4 months later, tumors recurred in the right side and anterior wall of the neobladder. We carried out transurethral resection of the bladder tumor again; the pathological diagnosis was high-grade pTa urothelial carcinoma with carcinoma in situ. Bacillus Calmette-Guérin instillation was carried out seven times into the neobladder, without any severe side-effects. Tumor recurrence was not observed up to 8 months after bacillus Calmette-Guérin treatment.
authors.affiliation: Division of Urology, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamashita
authors.forename: Masato
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Niwakawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ito
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000601:surgery; D015653:Cystectomy; D006801:Humans; D007082:Ileum / Q000637:transplantation; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014547:Urinary Diversion
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine
keywords: bacillus Calmette-Guérin; cystectomy; ileal neobladder; transurethral resection of bladder tumor; urothelial carcinoma