title: Optimization of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) beads by response surface methodology.
abstract: The paper describes development of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) [PVP] beads through ionotropic-gelation. Effects of amount of pectin and PVP on drug encapsulation efficiency (DEE), and cumulative drug release at 6h (R6h) were optimized by using response surface methodology. The optimized beads showed DEE of 96.58 ± 4.15% and R6h of 41.62 ± 2.18% with controlled drug release pattern. FTIR spectroscopy analysis revealed possible intermolecular hydrogen bonding, which could be formed between C=O groups of PVP and -OH groups of pectin in these beads. The swelling of these beads were influenced by pH of the medium.
authors.affiliation: Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: Samir
authors.initials: S
authors.lastname: Kalia
authors.forename: M Saquib
authors.initials: MS
authors.lastname: Hasnain
mesh_terms: D004008:Diclofenac / Q000031:analogs & derivatives* / Q000737:chemistry; D065546:Drug Liberation; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*
chemical_list: D004008:Diclofenac; D010368:Pectins; D011205:Povidone; C056498:aceclofenac
keywords: Drug release; Pectin; Poly(vinyl pyrrolidone)