title: Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring.
abstract: Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early diagnosis and metastasis monitoring are of the utmost importance. Hepatoma tissues synthesize various tumor-related proteins, genes, enzymes, microRNA, etc. and then secrete into the blood. Detections of circulating biomarkers are useful to find tumor at an early stage or monitor metastasis after postoperative treatment. This paper summarizes recent studies of specific biomarkers at early diagnosis or in monitoring metastasis or postoperative recurrence of HCC.
authors.affiliation: Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Yao
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Dong
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dengfu
authors.initials: D
authors.lastname: Yao
mesh_terms: D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D053673:Glypicans / Q000235:genetics / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D007527:Isoenzymes; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D035683:MicroRNAs / Q000097:blood; D009362:Neoplasm Metastasis; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D053673:Glypicans; D006360:Heat-Shock Proteins; D007527:Isoenzymes; D035683:MicroRNAs; D016212:Transforming Growth Factor beta; D000509:alpha-Fetoproteins; D007335:Insulin-Like Growth Factor II; D005723:gamma-Glutamyltransferase; D019098:Telomerase