title: [The associations between idiosyncratic adverse drug reactions and HLA alleles and their underlying mechanism].
abstract: With the advent of Twenty-First century, more and more genome-wide association studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were closely related with human leukocyte antigen (HLA) alleles, such as the associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic drug reactions, hapten hypothesis, danger signal hypothesis, pharmacological interaction (P-I) concept and autoimmune mechanism are proposed. In this paper, recent GWAS studies on the HLA-mediated adverse drug reactions and underlying mechanism are reviewed in detail.
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400044, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Hu
authors.initials: H
authors.lastname: Mei
authors.forename: Ya-Lan
authors.initials: YL
authors.lastname: Zhang
authors.forename: Xian-Chao
authors.initials: XC
authors.lastname: Pan
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Li
authors.initials: L
authors.lastname: Chao
mesh_terms: D000483:Alleles; D000493:Allopurinol / Q000009:adverse effects; D019380:Anti-HIV Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D015224:Dideoxynucleosides / Q000009:adverse effects; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics* / Q000276:immunology; D004791:Enzyme Inhibitors / Q000009:adverse effects; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000276:immunology; D059910:HLA-B15 Antigen / Q000276:immunology; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000276:immunology; D000099227:Abacavir
chemical_list: D000493:Allopurinol; D019380:Anti-HIV Agents; D000927:Anticonvulsants; D002220:Carbamazepine; D015224:Dideoxynucleosides; D004791:Enzyme Inhibitors; D006680:HLA Antigens; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D000099227:Abacavir; C483536:HLA-B*15:02 antigen; C484830:HLA-B*57:01 antigen; C500126:HLA-B*58:01 antigen