title: Protective role of statins in patients with acute coronary syndrome aged ≥ 75 years with low LDL-C who underwent percutaneous coronary intervention.
abstract: The effect of statins in patients with acute coronary syndrome (ACS) at advanced age with lower low-density lipoprotein cholesterol (LDL-C) levels undergoing percutaneous coronary intervention (PCI) remains unknown. We evaluated the effect of statins in 220 Chinese patients with ACS aged ≥ 75 years with low LDL-C undergoing PCI. Biomarkers were measured before and 6 hours after PCI, and patients were followed up for 1 year. Biomarkers in the statin group at 6 hours post-PCI were lower than controls (creatine kinase-myocardial band 14.2 ± 5.78 vs 47.3 ± 16.4 IU/L, P = .03; cardiac troponin I 0.36 ± 0.12 vs 1.33 ± 0.47 ng/mL, P = .01; and high-sensitivity C-reactive protein 7.6 ± 4.3 vs 13.6 ± 4.5 mg/L, P = .001, respectively). Significant differences were found in major adverse cardiac events at 1 year (P = .02-.01), while target lesion revascularization alone was less at 3 months between the 2 groups (P = .03). This study demonstrates that elderly patients with ACS having low LDL-C benefit from statins regardless of type, dosage, and duration of statin administration prior to PCI.
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Congya
authors.initials: C
authors.lastname: Bu
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yingxin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Hanying
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Hongya
authors.initials: H
authors.lastname: Han
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fang
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Yueping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Nie
authors.affiliation: Department of Cardiology, Beijing An zhen Hospital, Capital Medical University, Beijing, China wenxuebu2008@sina.com.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000517:prevention & control*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008297:Male; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein
keywords: acute coronary syndrome; advanced age; percutaneous coronary intervention; statin