title: Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults.
abstract: The purpose of this study was to observe exercise training-induced effects on adiponectin, leptin, and ghrelin. Twenty-nine older, healthy participants were classified as physically active (comparison group: N = 15, 70.9 ± 1.2 years) or physically inactive (exercise group: N = 14, 70.5 ± 1.4 years). Exercise group participants completed 12 weeks of combined aerobic and resistance exercise training, whereas comparison group participants maintained their current level of exercise and served as a physically active comparison group. Monocyte phenotype, as well as serum ghrelin, leptin, adiponectin, and soluble tumor necrosis factor receptor II were analyzed prior to and following the 12-week period. Ghrelin and adiponectin increased 47% and 55%, respectively, in exercise group participants following exercise training. Percent change in ghrelin (post and pre) was negatively correlated with the percent change in CD14+CD16+ monocytes (post and pre) in exercise group participants. Despite no changes in body mass, these data contribute to evidence for the anti-inflammatory effects of exercise.
authors.affiliation: Sealy Center on Aging, University of Texas Medical Branch at Galveston. m.markofski@utmb.edu.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Markofski
authors.affiliation: Department of Exercise Science, Chatham University, Pittsburgh, Pennsylvania.
authors.forename: Andres E
authors.initials: AE
authors.lastname: Carrillo
authors.affiliation: Department of Kinesiology and Health, Miami University, Ohio.
authors.forename: Kyle L
authors.initials: KL
authors.lastname: Timmerman
authors.affiliation: Office of Biostatistics, University of Texas Medical Branch, Galveston.
authors.forename: Kristofer
authors.initials: K
authors.lastname: Jennings
authors.affiliation: Department of Health and Physical Activity, University of Pittsburgh, Pennsylvania.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Coen
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign.
authors.forename: Brandt D
authors.initials: BD
authors.lastname: Pence
authors.affiliation: Department of Health and Human Performance, College of Charleston, South Carolina.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Flynn
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009000:Monocytes / Q000378:metabolism; D055070:Resistance Training
chemical_list: D052242:Adiponectin; D054439:Ghrelin
keywords: Adipokine; Anti-inflammatory.; Inflammation