title: Dynamics of skeletal muscle lipid pools.
abstract: Intramyocellular triacylglycerol (IMTG) is emerging as an important energy fuel source during muscle contraction and are adaptively increased in response to exercise, without adverse physiological effects. Paradoxically, elevated IMTG content in obese and type 2 diabetics has been linked to insulin resistance, highlighting the importance of IMTG pools in physiology and pathology. Two separate views suggest that IMTG dynamics are determinant for skeletal muscle fat oxidation, and that disruption of IMTG dynamics facilitates the accumulation of lipotoxic intermediates such as diacylglycerols and ceramides that interfere with insulin signaling. Thus, understanding the factors that control IMTG dynamics is crucial. Here we discuss recent literature describing the regulation of IMTG pools with a particular emphasis on lipases and lipid droplet (LD)-associated proteins.
authors.affiliation: Obesity Research Laboratory, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France; University of Toulouse, UMR1048, Paul Sabatier University, Toulouse, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Badin
authors.forename: Dominique
authors.initials: D
authors.lastname: Langin
authors.forename: Cedric
authors.initials: C
authors.lastname: Moro
mesh_terms: D000818:Animals; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008049:Lipase / Q000378:metabolism; D008066:Lipolysis / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; D008049:Lipase
keywords: ATGL; exercise; fat oxidation; insulin sensitivity; intramyocellular lipids; lipolysis; type 2 diabetes