title: Stability of bethanechol chloride in oral liquid dosage forms.
abstract: The chemical stability of bethanechol aqueous solutions prepared using either tablets, injection or powder was studied. For an aqueous solution prepared using tablets, the initial result was low (86.5%) and the pH value was 7.1. With storage at 25 deg C, the result increased to almost 100% in 12 days and the pH value decreased to about 3.4. For the solution prepared from the injection, the initial result was 100%. After 40 days' storage at 25*C, the pH value decreased from 7.0 to 6.0 and the result was still almost 100% of the label claim. The aqueous solutions prepared from powder in phosphate buffers (pH values between 3.0 and 6.8) retained almost 100% of the potency at all pH values.
authors.affiliation: Pharmaceutics Division, University of Houston.
authors.forename: V D
authors.initials: VD
authors.lastname: Gupta
authors.forename: J
authors.initials: J
authors.lastname: Maswoswe