title: Fetal and neonatal outcome in celiac disease.
abstract: Celiac disease (CD) is characterized by an abnormal immune response in susceptible individuals to dietary gluten derived from wheat, rye and barley. The disease affects not only the small bowel mucosa, but also many other extraintestinal organs resulting bone, liver, neurologic, skin and reproductive system disorders. The details of the pathogenic mechanism are not perfectly clear yet, but it is now proved that both humoral and cellular immune responses are triggered and autoimmune mechanisms are implicated. Studies have shown association of different pregnancy outcomes with maternal celiac disease. In this review, the most frequent fetal and neonatal outcome related to CD are presented, with a special focus on intrautherine growth restriction (IUGR) and prematurity. The need of active case finding of CD is discussed.
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Carol Davila" , Bucharest , Romania .
authors.forename: Nicolae
authors.initials: N
authors.lastname: Suciu
authors.forename: Liviu
authors.initials: L
authors.lastname: Pop
authors.forename: Eugenia
authors.initials: E
authors.lastname: Panaitescu
authors.forename: Ioan Dumitru
authors.initials: ID
authors.lastname: Suciu
authors.forename: Alina
authors.initials: A
authors.lastname: Popp
authors.forename: Ioana
authors.initials: I
authors.lastname: Anca
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005333:Fetus / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology; D011379:Prognosis