title: Comparison of postoperative morbidity between simultaneous bilateral and staged bilateral total knee arthroplasties: serological perspective and clinical consequences.
abstract: The present study compared simultaneous and two-staged (stages 1 and 2 with 8-month interval on average) bilateral TKAs in terms of postoperative serological status and clinical consequences. The decrease in hemoglobin over 2 weeks postoperatively was similar between groups. C-reactive protein levels and creatine phosphokinase index peaking on day 2 were significantly higher in the simultaneous group than in either staged group (P<0.05). Incidence of DVT on day 7 tended to be higher in the simultaneous group, but the difference was not significant. Considering the approximately 8-month interval and 2-month earlier functional recovery with stage 2 TKAs, 6 months were saved with the simultaneous bilateral TKA group. Collectively, simultaneous bilateral TKA is likely to offer a safe and effective procedure in appropriate clinical settings involving anti-bleeding and anti-venous thromboembolism prophylaxis.
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Niki
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Katsuyama
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Enomoto
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Toyama
authors.affiliation: Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Suda
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis; D003402:Creatine Kinase / Q000032:analysis; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009017:Morbidity; D020370:Osteoarthritis, Knee / Q000097:blood / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology*; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins; D002097:C-Reactive Protein; D003402:Creatine Kinase
keywords: bilateral; postoperative morbidity; simultaneous; total knee arthroplasty