title: MSI2 expression is decreased in grade II of gastric carcinoma.
abstract: Gastric cancer is the second most frequent cause of cancer death worldwide. In Iran, gastric cancer is the first cause of national cancer-related mortality in men and the second one in women. In mammals, the Musashi family of RNA binding proteins comprises the Musashi1 and Musashi2 proteins, encoded by the MSI1 and MSI2 genes. Mammalian Musashi contributes to the self-renewal of various types of stem cells. Furthermore, there is mounting evidence that stem cells exist in many tissues. Due to this, Msi appears to be associated with tumorigenesis. In the present study, 30 paired gastric tissue samples were examined for MSI2 gene expression by quantitative real-time RT-PCR. Our results demonstrated that the relative expression of the gene did not significantly alter between tumoral and non-tumoral tissues and different tumor types; but there was a statistical difference between the MSI2 gene expression in different tumor grades, of note between grade I and grade II.
authors.affiliation: Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran; Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.
authors.forename: Modjtaba
authors.initials: M
authors.lastname: Emadi-Baygi
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Nikpour
authors.forename: Faezeh
authors.initials: F
authors.lastname: Mohammad-Hashem
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Maracy
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Haghjooy-Javanmard
mesh_terms: D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D060787:Neoplasm Grading; D010641:Phenotype; D012333:RNA, Messenger / Q000032:analysis; D016601:RNA-Binding Proteins / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C438151:MSI2 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins
keywords: Gastric cancer; Gene expression; MSI2