title: Association of imaging classification of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke and renalase gene polymorphisms.
abstract: Cerebral atherosclerosis vascular stenosis is a common etiology for ischemic stroke and a major factor in recurrent stroke and vascular mortality. Recent studies suggest that renalase plays a role in hypertension and ischemic stroke, and may be involved in atherosclerosis. The aim of the present study was to investigate whether there were correlations between single-nucleotide polymorphisms (SNPs) in the renalase gene and severity of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke patients as determined by imaging. A total of 212 ischemic stroke patients and 244 healthy controls from the north Chinese Han population were enrolled in this study. Polymerase chain reaction and ligase detection reaction were used for SNP analysis. We classified the case samples by severity of the intracranial cerebral atherosclerotic vascular stenosis. Allele, genotype, and haplotype were analyzed in cases and controls, and logistic regression was used to adjust for bias due to conventional stroke risk factors. The allele and the genotype of rs10887800 in the renalase gene were both associated with severe intracranial cerebral atherosclerotic vascular stenosis (p = 0.013 and p = 0.049, respectively). No association was observed with severity for SNP rs2576178 or SNP rs2296545. Our findings show that the SNP rs10887800 in the renalase gene is closely associated with severe intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke patients of north Chinese Han origin.
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, People's Republic of China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Ruyou
authors.initials: R
authors.lastname: Zhang
authors.forename: Xijuan
authors.initials: X
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chunping
authors.initials: C
authors.lastname: Ning
authors.forename: Litao
authors.initials: L
authors.lastname: Sun
authors.forename: Jiawei
authors.initials: J
authors.lastname: Tian
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000145:classification / Q000175:diagnosis / Q000235:genetics
chemical_list: D008995:Monoamine Oxidase; C521557:renalase