title: Three new phenolics and other constituents from the seeds of Lithocarpus pachylepis.
abstract: Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-9 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC₅₀ values ranging from 10.9 to 34.7 μM.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
authors.forename: Guoxu
authors.initials: G
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Jingquan
authors.initials: J
authors.lastname: Yuan
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wu
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhou
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D029962:Fagaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts