title: The role of elective pelvic radiotherapy in clinically node-negative prostate cancer: a systematic review.
abstract: The role of elective radiotherapy of the pelvic nodal regions in clinically node-negative prostate cancer patients remains highly controversial. This review will address the difficulty of non-invasive nodal staging, even with more advanced imaging techniques, and will show that surgical staging still finds a relatively high percentage of patients with intermediate- or high-risk prostate cancer that have microscopic tumor invasion in the pelvic nodes. Finally, an overview of the current literature on elective pelvic irradiation will be provided.
authors.affiliation: Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: piet.dirix@uzleuven.be.
authors.forename: Piet
authors.initials: P
authors.lastname: Dirix
authors.affiliation: Department of Urology, University Hospitals Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Joniau
authors.affiliation: Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Van den Bergh
authors.affiliation: Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium.
authors.forename: Sofie
authors.initials: S
authors.lastname: Isebaert
authors.affiliation: Department of Radiology, University Hospitals Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Belgium.
authors.forename: Raymond
authors.initials: R
authors.lastname: Oyen
authors.affiliation: Department of Nuclear Medicine, University Hospitals Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Belgium.
authors.forename: Christophe M
authors.initials: CM
authors.lastname: Deroose
authors.affiliation: Department of Pathology, University Hospitals Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, Belgium.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lerut
authors.affiliation: Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium.
authors.forename: Karin
authors.initials: K
authors.lastname: Haustermans
mesh_terms: D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects; D008207:Lymphatic Metastasis; D008297:Male; D010388:Pelvis / Q000473:pathology / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*
keywords: Lymph nodes; Prostate cancer; Radiotherapy