title: Anti-allergic flavones from Arthraxon hispidus.
abstract: Bioactivity-guided fractionation for an EtOAc-soluble fraction of methanolic extract of Arthraxon hispidus, using primary cell assay with bone marrow-derived mast cells (BMMC), led to an isolation of six new flavones and nine known compounds. The structures of the new compounds were established by one dimensional (1D)- and 2D-NMR spectroscopic data, as luteolin 8-C-β-kerriopyranoside (1), luteolin 8-acetic acid methyl ester (2), 7-methyl-luteolin 8-C-β-(6-deoxyxylo-3-uloside) (3), apigenin 8-C-α-fucopyranoside (4), apigenin 8-C-β-fucopyranoside (5) and luteolin 8-C-β-fucopyranoside (6). All the isolates were evaluated for inhibitory activities on interleukin-6 release in the primary cultures using BMMC. Of the tested compounds, compounds 2, 3 and 10 were found to inhibit interleukin-6 release. Furthermore, compound 2 displayed inhibitory activity against prostaglandin D2, leukotriene C4, and β-hexosaminidase releases.
authors.affiliation: Central Research Laboratory, The Second Clinical Hospital of Jilin University.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Quan
authors.forename: Hee-Sung
authors.initials: HS
authors.lastname: Chae
authors.forename: Hyuk Hwan
authors.initials: HH
authors.lastname: Song
authors.forename: Kyoung-Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015850:Interleukin-6 / Q000276:immunology; D017997:Leukotriene C4 / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006109:Poaceae / Q000737:chemistry*; D015230:Prostaglandin D2 / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D047309:Flavones; D015850:Interleukin-6; D010936:Plant Extracts; D017997:Leukotriene C4; D015230:Prostaglandin D2