title: Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.
abstract: Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Chen-Xi
authors.initials: CX
authors.lastname: He
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Luo
authors.forename: Quan-Li
authors.initials: QL
authors.lastname: Zou
authors.forename: Yong-Xu
authors.initials: YX
authors.lastname: Zhao
authors.forename: Ratni
authors.initials: R
authors.lastname: Saini
authors.forename: San-Feng
authors.initials: SF
authors.lastname: Han
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Knölker
authors.forename: Li-Shun
authors.initials: LS
authors.lastname: Wang
authors.forename: Bao-Xue
authors.initials: BX
authors.lastname: Ge
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000235:genetics / Q000276:immunology*; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000276:immunology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology
chemical_list: D029742:Caenorhabditis elegans Proteins; C410905:DAF-12 protein, C elegans; D004268:DNA-Binding Proteins; D035683:MicroRNAs; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C474488:let-7 microRNA, C elegans; C073702:skn-1 protein, C elegans; D020928:Mitogen-Activated Protein Kinases; C463460:Pmk-1 protein, C elegans