title: A critical role for interleukin-1β in the progression of autoimmune diseases.
abstract: Interleukin-1β (IL-1β) belongs to IL-1 family and is a potent pro-inflammatory cytokine. It is known to be also involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. In addition to its pathophysiologic role in host protection, IL-1β promotes the progression of a number of autoimmune diseases. Most of such diseases can be controlled by anti-IL-1β treatment. This review discusses the contribution of IL-1β to the course of autoimmune diseases, such as rheumatic diseases, uveitis, autoimmune thyroid diseases (AITD), insulin-dependent diabetes mellitus (IDDM), autoimmune inner ear disease (AIED), multiple sclerosis (MS), myocarditis, hepatitis and kidney diseases. The critical involvement of IL-1β in the pathogenesis of autoimmune diseases provides targets for developing therapeutic treatment.
authors.affiliation: The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Zhao
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhou
authors.forename: Shao Bo
authors.initials: SB
authors.lastname: Su
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D053583:Interleukin-1beta / Q000276:immunology*
chemical_list: D053583:Interleukin-1beta
keywords: Autoimmune diseases; Biological therapy; Interleukin-1β