title: Aromatic glucosides from the seeds of Prunus davidiana.
abstract: Chemical investigation of the seeds of Prunus davidiana afforded seven new aromatic glucosides, i.e., the prupersins A-E (1-5) and compounds 6 and 7, as well as 11 known compounds. The structures of 1-7 were elucidated by spectroscopic data analysis and chemical evidence, and configurations were determined by hydrolysis experiments (1, 2, and 5) or electronic circular dichroism (6). Compounds 1-6 exhibited antioxidant activity aganist Fe²⁺-cysteine-induced rat liver microsomal lipid peroxidation, with malondialdehyde inhibitory rates of 50-67% and 53-57% at concentrations of 10⁻⁵ and 10⁻⁶ mol/L, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Chen
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Kang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005296:Ferrous Compounds / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects; D015394:Molecular Structure; D027861:Prunus / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005296:Ferrous Compounds; D005960:Glucosides; D008315:Malondialdehyde; D003545:Cysteine