title: Changing incidence trends of cutaneous T-cell lymphoma.
abstract: OBJECTIVE
  Cutaneous T-cell lymphoma (CTCL) incidence and survival have been increasing steadily for over 25 years.
  
  
  OBJECTIVE
  We sought to measure changes in CTCL incidence trends and survival rates.
  
  
  METHODS
  Population-based study. The CTCL incidence and survival data were obtained from the 9 original registries (1973-2009) and the 4 additional registries (1992-2009) of the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute (NCI). Trend analysis was performed using the Joinpoint Regression Program provided by the NCI. Survival analysis was performed using the SeerSTAT statistical software of the NCI. The total number of cases of CTCL from 1973 to 2009 was 6230.
  
  
  METHODS
  Diagnoses of CTCL.
  
  
  RESULTS
  Overall CTCL incidence has stabilized since 1998 (95% CI, 1994-2002), with an annual percent change (APC) of 5.7% from 1973 to 1998 (95% CI, 4.9%-6.5%) and an APC of 0.1% from 1998 to 2009 (95% CI, -1.4% to 1.5%). Similar incidence stabilization patterns were found in subgroup analyses of race, sex, age, diagnosis, and registry. Five-year CTCL survival rates increased until 2004.
  
  
  CONCLUSIONS
  The incidence of CTCL is no longer increasing. Causes for this trend change may include real incidence stabilization, stabilization of physician detection, or artifact.
authors.affiliation: Department of Dermatology, Brown University, Providence, Rhode Island2Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, Rhode Island.
authors.forename: Kaveri
authors.initials: K
authors.lastname: Korgavkar
authors.forename: Michael
authors.initials: M
authors.lastname: Xiong
authors.forename: Martin
authors.initials: M
authors.lastname: Weinstock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012042:Registries; D018426:SEER Program / Q000639:trends*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D055815:Young Adult