title: A complex variant t(3;15) (q26;q13) representing cryptic/masked acute promyelocytic leukaemia with a novel breakpoint of chromosome 15-a case report.
abstract: Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique clinical presentation, often with disseminated intravascular coagulation, and has a targeted therapy for its treatment in the form of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). Here, we report a complex type of variant APML t(3;15) (q26;q13), the need for conventional karyotyping for diagnosing such rare variants, and its response to ATRA and ATO.
authors.affiliation: Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Banglore, Karnataka 560029, India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Appachu
authors.forename: Chintaparthi
authors.initials: C
authors.lastname: Obulareddy
authors.forename: Nagesh T
authors.initials: NT
authors.lastname: Sirsath
authors.forename: Kuntejowdahalli C
authors.initials: KC
authors.lastname: Lakshmaiah
authors.forename: Prasanna
authors.initials: P
authors.lastname: Kumari
keywords: APML; ATRA; variant translocation