title: An infant with prenatally diagnosed congenital anaplastic astrocytoma who remains disease-free after proton therapy.
abstract: The authors present a rare of prenatally diagnosed congenital anaplastic astrocytoma. A 9-month-old boy had three recurrences despite two surgical resections and various chemotherapeutic regimens. He underwent the 3rd gross tumor removal at 11 months of age, followed by proton therapy, and now he remains disease-free for 3 yr without a significant neurocognitive dysfunction. This is the 1st case of a pediatric tumor treated by proton therapy in Korea, and proton therapy may be a treatment of choice for a congenital anaplastic astrocytoma in infants and young children, considering limitation of radiation therapy.
authors.affiliation: Joy Pediatric Clinic, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Shin
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kwon
authors.forename: Hyeon Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Byung Kiu
authors.initials: BK
authors.lastname: Park
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Shin
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Kim
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D018572:Disease-Free Survival; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011296:Prenatal Diagnosis; D061766:Proton Therapy; D014057:Tomography, X-Ray Computed
keywords: Congenital Anaplastic Astrocytoma; Proton Therapy; Recurrence