title: The value of serum albumin as a novel independent marker for prognosis in patients with endometrial cancer.
abstract: OBJECTIVE
  Hypoalbuminemia, a known marker for malnutrition and increased morbidity and mortality, has been associated with impaired prognosis in different cancer entities. The present study investigates the prognostic value of pre-treatment serum albumin levels for survival in patients with endometrial cancer.
  
  
  METHODS
  Within the present cohort study, we evaluated 337 consecutive patients with endometrial cancer and investigated the association of pre-treatment serum albumin levels and clinical-pathological parameters. We performed univariate log-rank tests and multivariable Cox regression models to assess the association between pre-treatment serum albumin levels and survival.
  
  
  RESULTS
  Pre-treatment serum albumin levels were inversely proportionally associated with FIGO tumor stage, histological grade, and patients' age. In a multivariable analysis pre-treatment serum albumin levels (p = 0.02 and p = 0.001), FIGO tumor stage (p < 0.001 and p < 0.001), and histological grade (p = 0.002 and p < 0.001) were independently associated with disease-free and progression-free survival, respectively.
  
  
  CONCLUSIONS
  Pre-treatment serum albumin is a novel and independent prognostic parameter for disease-free and progression-free survival in patients with endometrial cancer.
authors.affiliation: Department of Gynecology and Gynecological Oncology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: veronika.seebacher@meduniwien.ac.at.
authors.forename: Veronika
authors.initials: V
authors.lastname: Seebacher
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Clemens
authors.initials: C
authors.lastname: Tempfer
authors.forename: Lukas
authors.initials: L
authors.lastname: Hefler
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000175:diagnosis*; D008875:Middle Aged; D011379:Prognosis; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D012709:Serum Albumin
keywords: Albumin; Endometrial cancer; Hypoalbuminemia; Prognosis; Survival