title: Associations of HLA class I antigen specificities and haplotypes with disease progression in HIV-1-infected Hans in Northern China.
abstract: The human leukocyte antigen (HLA) allele frequencies, which differ among various ethnic populations, may result in population-specific effects on HIV-1 disease progression. No large-scale study has yet been conducted on the Chinese population. In this study, HLA class I antigen specificities were determined in a cohort including 105 long-term non-progressors (LTNPs) and 321 typical progressors (TPs), who were recruited from HIV-1-infected Northern Han Chinese, to determine the associations between certain HLA types and HIV-1 disease progression. The frequencies of HLA class I specificities and haplotypes among the two groups were compared using binary logistic stepwise regression. Results showed that HLA-A(∗)30-B(∗)13-C(∗)06 (OR = 0.387, P = 0.019) and B(∗)67 (OR = 0.134, P = 0.005) were associated with a long-term non-progressing condition, and C(∗)01 (OR = 2.539, P = 0.050) was overrepresented in TPs after adjusting for non-genetic factors (sex, age, the location of patients, HIV subtype and the route of infection). The influence of HLA homozygosity on HIV disease progression was also analyzed. However, homozygosity at HLA-A, HLA-B or HLA-C conferred no observable disadvantage in our study population (P = 0.730, 0.246 and 0.445, respectively). These findings suggest that the host's genetics make important contributions to HIV viral control and may help to develop peptide-based vaccines for this population.
authors.affiliation: Key Laboratory of AIDS Immunology of the Ministry of Health, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Han
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Baogui
authors.initials: B
authors.lastname: Liu
authors.forename: Chunming
authors.initials: C
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Ou
authors.initials: O
authors.lastname: Chen
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Hu
authors.forename: Fanming
authors.initials: F
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: AIDS; CTL; HIV-1; HLA; KIR; LD; LTNP; NK; PBD; PCR-SSP; RP; TP; VL; acquired immunodeficiency syndrome; cytotoxic T lymphocyte; human immunodeficiency virus type-1; human leukocyte antigen; killer Ig-like receptor; linkage disequilibrium; long-term non-progressor; natural killer; paid blood donations; polymerase chain reaction sequence-specified primer; rapid progressor; typical progressor; viral load