title: Association between lean and fat mass and indicators of bone health in prepubertal caucasian children.
abstract: OBJECTIVE
  Childhood and adolescence are critical periods for bone growth. The independent association between lean and fat mass and indicators of bone health in children is not yet known. We aim to examine the association between each of lean and fat mass and indicators of bone health in 8- to 10-year-old prepubertal Caucasian children.
  
  
  METHODS
  We present a cross-sectional analysis of baseline data from the QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) cohort which study the natural history of obesity. Study participants (n = 483) included prepubertal children aged 8-10 years and their biological parents. Whole-body bone mineral content (BMC, g), bone area (cm²), bone mineral density (BMD, g/cm²), lean mass (kg), and fat mass (kg) were measured by dual-energy X-ray absorptiometry. Data analyses include multiple linear regressions adjusted for potential confounding variables.
  
  
  RESULTS
  A 1-kg increase in lean mass was associated with 28.42 g, 19.88 cm², and 0.007 g/cm² increase in whole-body BMC, bone area and BMD respectively. A 1-kg increase in fat mass was associated with 9.32 g, 8.02 cm², and 0.002 g/cm² increase in whole-body BMC, bone area and BMD, respectively.
  
  
  CONCLUSIONS
  Increasing lean mass in children may help optimize bone acquisition and prevent future osteoporosis.
authors.affiliation: Oral Health and Society Unit, Faculty of Dentistry, McGill University, Montreal, Que., Canada.
authors.forename: Khady
authors.initials: K
authors.lastname: Kâ
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Rousseau
authors.forename: Marie
authors.initials: M
authors.lastname: Lambert
authors.forename: Jennifer
authors.initials: J
authors.lastname: O'Loughlin
authors.forename: Mélanie
authors.initials: M
authors.lastname: Henderson
authors.forename: Angelo
authors.initials: A
authors.lastname: Tremblay
authors.forename: Nathalie
authors.initials: N
authors.lastname: Alos
authors.forename: Belinda
authors.initials: B
authors.lastname: Nicolau
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male