title: Bioenergetic medicine.
abstract: Here we discuss a specific therapeutic strategy we call 'bioenergetic medicine'. Bioenergetic medicine refers to the manipulation of bioenergetic fluxes to positively affect health. Bioenergetic medicine approaches rely heavily on the law of mass action, and impact systems that monitor and respond to the manipulated flux. Since classically defined energy metabolism pathways intersect and intertwine, targeting one flux also tends to change other fluxes, which complicates treatment design. Such indirect effects, fortunately, are to some extent predictable, and from a therapeutic perspective may also be desirable. Bioenergetic medicine-based interventions already exist for some diseases, and because bioenergetic medicine interventions are presently feasible, new approaches to treat certain conditions, including some neurodegenerative conditions and cancers, are beginning to transition from the laboratory to the clinic.
authors.affiliation: Departments of Neurology, Molecular and Integrative Physiology, Biochemistry and Molecular Biology, University of Kansas School of Medicine, Kansas City, KS, USA; Alzheimer's Disease Center, University of Kansas Medical Center, Fairway, KS, USA.
authors.forename: Russell H
authors.initials: RH
authors.lastname: Swerdlow
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D028361:Mitochondrial Diseases / Q000188:drug therapy* / Q000378:metabolism; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism
keywords: Alzheimer's disease; cancer; glycolysis; law of mass action; mitochondria; neurodegeneration