title: [The outbreak of nosocomial infection by Mycobacterium chelonae chemovar niacinogenes and the cause of its spread].
abstract: Mycobacteria consist of 2 large groups: one is the tuberculosis complex, and the other is nontuberculous mycobacterium (NTM). Most of the NTM are generally non-virulent bacteria, but some NTMs have pathogenicity to humans. There are many reports of nosocomial infection cases caused by common bacteria such as multidrug-resistant Pseudomonas aeruginosa. Also, some cases of in-hospital infection due to NTM were reported. Unlike common bacteria, detection of mycobacteria is affected by various factors, such as stainability, time for colony forming, temperature and nutrition Mycobacterium chelonae chemovar niacinogenes was isolated from 5 patients in 73 nosocomial infection cases (60 patients and 13 suspected cases) at a certain hospital during the period from March 2007 until January 2009. One of the reasons for the expansion of infection and difficulty in identification of the bacteria was the properties of this mycobacterium. This bacterium was very faintly stained with Gram-staining. Therefore, this mycobacterium could only be detected at a hospital when Ziehl-Neelsen stain and the cultivation at 28 degrees C for more than 5 days were performed. MICs for Cefmenoxime and Tosufloxacin of the isolates were more than 128 microg/mL. The isolates and type strasin of M. chelonae chemovar niacinogenes were also resistant to other drugs.
authors.affiliation: Molecular Epidemiology and Genetic Identification Division, Department of Mycobacteria References and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kazumi
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Murase
authors.forename: Kazue
authors.initials: K
authors.lastname: Ishii
authors.forename: Shinji
authors.initials: S
authors.lastname: Maeda
mesh_terms: D003428:Cross Infection / Q000382:microbiology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000187:drug effects / Q000302:isolation & purification