title: Antioxidant xanthones from Swertia mussotii, a high altitude plant.
abstract: Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-β-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(β-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(β-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(β-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where 1 is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Cui-Ting
authors.initials: CT
authors.lastname: Luo
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Mao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Fang-Lan
authors.initials: FL
authors.lastname: Liu
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Mao-Xun
authors.initials: MX
authors.lastname: Yang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China.
authors.forename: Heru
authors.initials: H
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou 510632, PR China.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, PR China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000531:Altitude; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D029967:Swertia / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000588647:3,5,6,8-tetrahydroxyxanthone-1-C-glucoside; D000975:Antioxidants; D005960:Glucosides; D010936:Plant Extracts; D044004:Xanthones
keywords: Antioxidant; ORAC; Swertia L.; Swertia mussotii; Xanthones