title: Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome.
abstract: Occasionally, patients with acute Epstein-Barr virus (EBV) infection develop hemophagocytic syndrome (HPS). Acute kidney injury (AKI) is considered a strong prognostic factor, but very few data are available about the biopsy-proven renal involvement of EBV-HPS. Here we describe a previously healthy 17-year-old girl with EBV-HPS. Combination therapy failed and renal necropsy was performed. The renal histology showed that intact glomeruli, remarkable interstitial edema and some cellular infiltration, and protein casts. These findings were compatible with cytokine nephropathy as recently advocated. We suggest that hypercytokinemia may play an important role in the pathophysiology in AKI of EBV-HPS.
authors.affiliation: Division of Nephrology, Department of Medicine, Showa University Fujigaoka Hospital , Yokohama , Japan and.
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Nagayama
authors.forename: Ashio
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Shigeki
authors.initials: S
authors.lastname: Iwasaki
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology* / Q000473:pathology; D000293:Adolescent; D016207:Cytokines / Q000097:blood*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications*
chemical_list: D016207:Cytokines