title: [Identification and evaluation of the neuroleptic activity of phenotropil].
abstract: The neuroleptic (antipsychotic) activity of phenotropil was studied in an experimental animal model. Phenotropil had a marked neuroleptic activity in models of positive (apomorphine-induced verticalization test) and negative (5-HTP-induced hyperkinesis test) symptoms of psychoses as well as in the m-cholinergic pathway hyperactivation (arecoline-induced tremor test). The compound markedly antagonized haloperidol catalepsy. Used in a single dose or as a course treatment, phenotropil did not provoke aggression nor intensify it. In contrast to typical and atypical antipsychotics, phenotropil had no sedative action and other adverse effects. It exhibited a positive effect on exploratory behavior and motor activity, had anxiolytic and antidepressant action.
authors.forename: V I
authors.initials: VI
authors.lastname: Akhapkina
authors.forename: R V
authors.initials: RV
authors.lastname: Akhapkin
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010889:Piracetam / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; C037917:4-phenylpiracetam; D010889:Piracetam