title: [Secondary osteoporosis or secondary contributors to bone loss in fracture. Metabolic bone disease and fracture induced by drugs].
abstract: Many medications can increase fracture risk. Osteoporosis is classified as either primary or secondary. Drug-induced osteoporosis is a type of secondary osteoporosis. Glucocorticoids are the most common cause of drug-induced osteoporosis. But other drugs can increase fracture risk, such as thyroxine overdose, gonadotropin-releasing hormone (GnRH) agonists, aromatase inhibitors, thiazolidines, proton pump inhibitors, loop diuretics, anticoagulant drugs, selective serotonin reuptake inhibitors (SSRI) , tricyclic antidepressants, anticonvulsant, and so on. This review will discuss clinical trials and the mechanisms underlying drug-induced fracture.
authors.affiliation: Toranomon Hospital Endocrine Center, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced*; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D054328:Proton Pump Inhibitors