title: Regulation of luminal acidification by the V-ATPase.
abstract: Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility. This review focuses on the regulation of V-ATPase-dependent luminal acidification in renal intercalated cells and epididymal clear cells, which are key players in these physiological processes.
authors.affiliation: Program in Membrane Biology, Center for Systems Biology, Nephrology Division, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Breton
authors.forename: Dennis
authors.initials: D
authors.lastname: Brown
mesh_terms: D000141:Acidosis, Renal Tubular / Q000201:enzymology / Q000235:genetics; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004822:Epididymis / Q000201:enzymology*; D020022:Genetic Predisposition to Disease; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007248:Infertility, Male / Q000201:enzymology / Q000235:genetics; D007668:Kidney / Q000201:enzymology*; D008297:Male; D009154:Mutation; D010641:Phenotype; D025262:Vacuolar Proton-Translocating ATPases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D025262:Vacuolar Proton-Translocating ATPases