title: Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function.
abstract: A 2-oxoglutaric acid (2-OG) probe bearing a methylene group introduced at the C4 position and a vinyl group to replace the carbonyl group at the C2 position elicited characteristic affinity for NtcA, the 2-OG receptor, while maintaining the signaling function of the parent natural metabolite 2-OG. This discovery opens new perspectives in the design, synthesis, and implementation of specific 2-OG analogues as molecular probes for investigating the complex 2-OG signaling pathways.
authors.affiliation: Aix-Marseille Université , CINaM CNRS UMR 7325, 13288 Marseille, France, College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P.R. China, Molecular Simulation Engineering Laboratory, University of Trieste , 34127 Trieste, Italy, National Interuniversity Consortium for Material Science and Technology, Research Unit MOSE-DEA, Trieste University , Italy, Spectropole , Faculté de Saint-Jérôme, Marseille, France, and Aix-Marseille Université , LCB CNRS UMR 7283, 13402 Marseille, France.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Erik
authors.initials: E
authors.lastname: Laurini
authors.forename: Paola
authors.initials: P
authors.lastname: Posocco
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.forename: Fabio
authors.initials: F
authors.lastname: Ziarelli
authors.forename: Annick
authors.initials: A
authors.lastname: Janicki
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fermeglia
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pricl
authors.forename: Cheng-Cai
authors.initials: CC
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D017033:Anabaena / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D007656:Ketoglutaric Acids