title: [Dependency syndrome and hyperalgesia due to an opioid therapy for curative treatable pain. Case report of an apparent palliative patient].
abstract: Opioids are an essential part of cancer pain management but particularly in this patient group physicians could misinterpret opioid-induced potentially life-threatening side effects within the central nervous system (CNS) or hyperalgesia as a consequence of tumor progression. In this case increasing the opioid dose or switching to rapidly acting opioids may trigger a vicious circle. We describe a case report of a male patient who was treated with high doses of transdermal and endonasal fentanyl 2 years after pancreatomy due to cancer. The patient was referred to the palliative care unit presenting with delirious behavior and 30-40 severe abdominal pain attacks/day. After withdrawal of the opioid medication all CNS symptoms disappeared. Further diagnostics revealed multiple incisional hernia as the reason of the pain syndrome. The patient recovered after herniotomy and has now been pain free without any pain medication for more than 16 months. This case report underlines again the necessity of pain diagnostics also in assumed palliative patients with the risks of high dose opioid treatment.
authors.affiliation: Abteilung für Schmerzmedizin, Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum, Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Michel-Lauter
authors.forename: K
authors.initials: K
authors.lastname: Bernardy
authors.forename: A
authors.initials: A
authors.lastname: Schwarzer
authors.forename: V
authors.initials: V
authors.lastname: Nicolas
authors.forename: C
authors.initials: C
authors.lastname: Maier
mesh_terms: D000203:Activities of Daily Living / Q000145:classification* / Q000523:psychology*; D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000601:surgery*; D003951:Diagnostic Errors; D004185:Disability Evaluation; D005283:Fentanyl / Q000009:adverse effects* / Q000627:therapeutic use; D046449:Hernia, Abdominal / Q000175:diagnosis / Q000601:surgery; D059685:Herniorrhaphy; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D008297:Male; D009293:Opioid-Related Disorders / Q000175:diagnosis* / Q000523:psychology; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery; D012086:Reoperation
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl