title: One-step synthesis of amphiphilic hyperbranched amylopectin derivatives, characterization and use as functional nanovehicles.
abstract: Amylopectin is a naturally hyperbranched biopolymer with an extremely high molecular weight. Furthermore, this material is non-toxic in nature, and exhibits good biocompatibility and biodegradability properties. Herein, we describe the development of a one-step reaction strategy for the synthesis of amphiphilic high-molecular-weight hyperbranched amylopectin derivatives with hydrophobic shells and large hydrophilic cores. The chemical structures of the resulting materials were characterized using FTIR spectroscopy, solid-state (13)C cross-polarization/magic angle spinning NMR spectroscopy and gas chromatography. The results from transmission electron microscopy, fluorescence spectroscopy, and UV-vis analysis confirmed that the hyperbranched amylopectin derivatives were composed of hydrophobic shells with cholesteryl residues and hydrophilic amylopectin cores. These amylopectin derivatives exhibited high encapsulation capabilities toward water-soluble molecules, and could be used as functional nanovehicles for the controlled release of water-soluble molecules, and the in situ synthesis of metallic nanoparticles.
authors.affiliation: Institute of Polymer Science, Key Laboratory of Designed Synthesis and Application of Polymer Material, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zeng
authors.forename: Jizhou
authors.initials: J
authors.lastname: Fan
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Deng
authors.forename: Jiayun
authors.initials: J
authors.lastname: Tan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Deng
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
authors.forename: Liqun
authors.initials: L
authors.lastname: Yang
mesh_terms: D000687:Amylopectin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D002214:Capsules; D060326:Chemistry Techniques, Synthetic; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D006878:Hydroxides / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D008970:Molecular Weight; D049329:Nanostructures / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006878:Hydroxides; D014867:Water; D000687:Amylopectin; C031356:hydroxide ion
keywords: Amylopectin; Controlled release; Hyperbranched polysaccharide; Metallic nanoparticle; Nanovehicle