title: Association of 25-hydroxyvitamin D with metabolic syndrome in patients with psoriasis: a case-control study.
abstract: Vitamin D deficiency is associated with higher cardiovascular risk and metabolic syndrome (MeS) criteria. The main objective of this study was to analyse the association of 25-hydroxyvitamin D (25-OHD) serum levels with MeS (National Cholesterol Education Program-Adult Treatment Panel-III criteria) in 46 Spanish patients with psoriasis, but without arthritis and systemic treatment, and 46 control subjects, matched by sex and age. The patients with psoriasis showed significantly lower level of 25-OHD than controls (30.5 vs. 38.3 ng/ml; p = 0.0001). Patients with MeS had significantly lower serum levels of 25-OHD than those without MeS (24.1 ± 7.5 vs. 32.8 ± 8.9, p = 0.007), and a negative correlation was found between 25-OHD and waist circumference, diastolic blood pressure, fasting glucose, and triglyceridaemia. In the control group no significant correlation between 25-OHD and MeS was found. Al-though the sample was small, our results suggest a potential protective role for 25-OHD in the metabolic profile of patients with psoriasis without arthritis.
authors.affiliation: Department of Dermatology, San Cecilio University Hospital, ES-18012 Granada, Spain.
authors.forename: Jacinto
authors.initials: J
authors.lastname: Orgaz-Molina
authors.forename: César
authors.initials: C
authors.lastname: Magro-Checa
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Arrabal-Polo
authors.forename: Enrique
authors.initials: E
authors.lastname: Raya-Álvarez
authors.forename: Ramón
authors.initials: R
authors.lastname: Naranjo
authors.forename: Agustin
authors.initials: A
authors.lastname: Buendía-Eisman
authors.forename: Salvador
authors.initials: S
authors.lastname: Arias-Santiago
mesh_terms: D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000150:complications; D013472:Sunlight; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D