title: Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.
abstract: Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.
authors.affiliation: Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, MBC#98-16, P.O. Box 3354, Riyadh, 11211, Saudi Arabia, Shahab@kfshrc.edu.sa.
authors.forename: Shahab
authors.initials: S
authors.lastname: Uddin
authors.forename: Azhar R
authors.initials: AR
authors.lastname: Hussain
authors.forename: Omar S
authors.initials: OS
authors.lastname: Khan
authors.forename: Khawla S
authors.initials: KS
authors.lastname: Al-Kuraya
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D063646:Carcinogenesis / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D054411:Receptors, Leptin / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D020738:Leptin; D054411:Receptors, Leptin