title: Psoriasis in hyper IgE syndrome - a case report.
abstract: BACKGROUND
  Hyper IgE syndrome (HIES) is a rare primary immune deficiency, described as Job(`)s syndrome characterized by increased serum levels of IgE, eczema, recurrent cutaneous and pulmonary infections. In this paper, we presented a case of Hyper IgE syndrome.
  
  
  METHODS
  A 16-year-old Iranian boy presented with a one year history of skin lesions in knees and elbows was diagnosed of psoriasis disease. He had a history of recurrent infections including otitis media, pneumonia, diarrea and skin infection. Laboratory results showed increased level of total IgE and normal in other immunoglobulin. Histologic finding showed hyperkeratosis, parakeratosis of acanthotic epidermis with regular elongation of rete ridges diagnose psoriasis disorder.
  
  
  CONCLUSIONS
  In conclusion, this is the first case of hyper IgE patient with psoriasis disorder. We addressed the important laboratory findings and actual theories explaining possible association between hyper IgE immunoglobulinemia and psoriasis disorder.
authors.affiliation: Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Ghaffari
authors.forename: Saeed
authors.initials: S
authors.lastname: Abedian-Kenari
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Farzad
authors.initials: F
authors.lastname: Gohardehi
keywords: Hyper IgE syndrome; Immune deficiency; Psoriasis