title: Comparison of topical sucralfate and silver sulfadiazine cream in second degree burns in rats.
abstract: BACKGROUND
  The most prevalent topical treatment for partial thickness burns is silver sulfadiazine 1% (SSD). Recent studies have shown that the healing of partial thickness burns is delayed with the use of SSD. One of the potential burn dressings is sucralfate.
  
  
  OBJECTIVE
  With this study the authors have aimed to analyze comparatively the effects of sucralfate and SSD on second degree burn wounds in rats.
  
  
  METHODS
  Forty-eight male rats were divided into three equal groups. A burn model was constituted on the back of all rats. The burned areas in the first, second and third groups were covered daily with sucralfate, SSD and cold cream (control), respectively. At the end of the 7th, 14th, 21st and 28th day, the rats were anesthetized and the burned skin tissue samples were collected for histopathological examination.
  
  
  RESULTS
  At the end of the study, the epidermis and horny layer was completely formed in the SSD and sucralfate group; however the appendix of skin was just formed in the sucralfate group. Also the percentage of wound healing was calculated at 76%, 91% and 100% respectively in the control, silver sulfadiazine and sucralfate groups.
  
  
  CONCLUSIONS
  Sucralfate is known to have multiple beneficial effects on wound healing. Using topical sucralfate accelerates the burn wound healing process in comparison with both the control and SSD groups and can be used as an adjunctive or alternative agent in the future.
authors.affiliation: Qazvin University of Medical Sciences, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Beheshti
authors.forename: Younes
authors.initials: Y
authors.lastname: Shafigh
authors.forename: Amir-Abdollah
authors.initials: AA
authors.lastname: Zangivand
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Samiee-Rad
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Hassanzadeh
authors.forename: Navid
authors.initials: N
authors.lastname: Shafigh
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D063465:Skin Cream; D013392:Sucralfate / Q000008:administration & dosage*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D013392:Sucralfate; D012837:Silver Sulfadiazine