title: Anti-psoriatic therapy recovers high-density lipoprotein composition and function.
abstract: Psoriasis is a chronic inflammatory disorder associated with increased cardiovascular mortality. Psoriasis affects high-density lipoprotein (HDL) composition, generating dysfunctional HDL particles. However, data regarding the impact of anti-psoriatic therapy on HDL composition and function are not available. HDL was isolated from 15 psoriatic patients at baseline and after effective topical and/or systemic anti-psoriatic therapy and from 15 age- and sex-matched healthy controls. HDL from psoriatic patients showed a significantly impaired capability to mobilize cholesterol from macrophages (6.4 vs. 8.0% [(3)H]cholesterol efflux, P<0.001), low paraoxonase (217 vs. 350 μM(-1) minute(-1) mg(-1) protein, P=0.011) and increased Lp-PLA2 activities (19.9 vs. 12.1 nM(-1) minute(-1) mg(-1) protein, P=0.028). Of particular interest, the anti-psoriatic therapy significantly improved serum lecithin-cholesterol acyltransferase activity and decreased total serum lipolytic activity but did not affect serum levels of HDL-cholesterol. Most importantly, these changes were associated with a significantly improved HDL-cholesterol efflux capability. Our results provide evidence that effective anti-psoriatic therapy recovers HDL composition and function, independent of serum HDL-cholesterol levels, and support to the emerging concept that HDL function may be a better marker of cardiovascular risk than HDL-cholesterol levels.
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Holzer
authors.affiliation: Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address: peter.wolf@medunigraz.at.
authors.forename: Peter
authors.initials: P
authors.lastname: Wolf
authors.affiliation: Department of Dermatology, Medical University of Graz, Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Inzinger
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Trieb
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
authors.forename: Sanja
authors.initials: S
authors.lastname: Curcic
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
authors.forename: Lisa
authors.initials: L
authors.lastname: Pasterk
authors.affiliation: Department of Dermatology, Medical University of Graz, Graz, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weger
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
authors.forename: Akos
authors.initials: A
authors.lastname: Heinemann
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria. Electronic address: gunther.marsche@medunigraz.at.
authors.forename: Gunther
authors.initials: G
authors.lastname: Marsche
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D016824:Antigens, Human Platelet / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality; D002784:Cholesterol / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008066:Lipolysis / Q000187:drug effects / Q000502:physiology; D008075:Lipoproteins, HDL / Q000097:blood*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism*; D012307:Risk Factors; D014316:Tritium
chemical_list: D016824:Antigens, Human Platelet; D008075:Lipoproteins, HDL; C083451:human platelet antigen 1b; D014316:Tritium; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D043303:Aryldialkylphosphatase