title: Tissue protection by erythropoietin: new findings in a moving field.
abstract: Two groups elucidate novel mechanisms of tissue protection by erythropoietin (EPO). Hu et al. demonstrate that Klotho's protective effect against oxidant-induced cytotoxicity is partially mediated by an increase in the endogenous expression of the classical EPO receptor (EpoR). While erythropoiesis is stimulated by the canonical EpoR homodimer, the tissue-protective effects of EPO are mediated through a heterodimeric 'tissue-protective' receptor. Coldewey et al. demonstrate a protective role of the 'tissue-protective' EpoR against acute kidney injury.
authors.affiliation: Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Tokyo, Japan. mnangaku-tky@umin.ac.jp
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control*; D000818:Animals; D053648:Cytokine Receptor Common beta Subunit / Q000378:metabolism*; D019610:Cytoprotection / Q000502:physiology*; D004921:Erythropoietin / Q000627:therapeutic use*; D005966:Glucuronidase / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D000090265:Klotho Proteins; D008297:Male; D017467:Receptors, Erythropoietin / Q000502:physiology*; D018805:Sepsis / Q000150:complications*
chemical_list: D053648:Cytokine Receptor Common beta Subunit; D017467:Receptors, Erythropoietin; D004921:Erythropoietin; D005966:Glucuronidase; D000090265:Klotho Proteins