title: Inpatient treatment costs of status epilepticus in adults in Germany.
abstract: OBJECTIVE
  Status epilepticus (SE) is an important neurological emergency and a significant source of direct costs related to hospitalization; however, no cost-of-illness (COI) studies have been performed in Europe. The objective of this study was to determine and characterize hospital costs related to the acute inpatient treatment of SE and to provide national estimates of SE hospitalization costs.
  
  
  METHODS
  Adult inpatient treatment costs related to SE and costs attributable to epilepsy-related hospital admissions were derived from billing data of participating hospitals.
  
  
  RESULTS
  During the 4-month study period a total of 96 patients (59.5 ± 21.6 years; 52 male) received inpatient treatment for epilepsy-related reasons, 10 of these (10.4%) were treated for SE. Epilepsy was newly diagnosed in 30/96 patients (31.3%), of whom five presented with SE. The admission costs related to SE (€8347 ± 10,773 per patient per admission) were significantly higher than those related to admissions of patients with newly diagnosed (€1998 ± 1089; p = 0.014) or established epilepsy (€3475 ± 4413; p = 0.026). Of the total inpatient costs (€346,319) 24.4% were attributable to SE, 14.4% to newly diagnosed epilepsy without SE (n = 25) and 61.2% to complications of established epilepsy (n = 61). Extrapolation to the whole of Germany (population 82 million) indicates that SE causes hospital costs of more than €83 million per year while the total of epilepsy-related inpatient treatment costs amounts to €342 million.
  
  
  CONCLUSIONS
  Acute treatment of SE is responsible for a high proportion of hospital costs associated with epilepsy. With a high incidence of SE in the elderly population, the health care systems will face an increasing number of presentations with SE and its associated costs, underlining the necessity to further evaluate the burden and optimize the treatment of SE.
authors.affiliation: Department of Neurology and Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany. Electronic address: adam.strzelczyk@med.uni-marburg.de.
authors.forename: Adam
authors.initials: A
authors.lastname: Strzelczyk
authors.forename: Susanne
authors.initials: S
authors.lastname: Knake
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
authors.forename: Hajo M
authors.initials: HM
authors.lastname: Hamer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005858:Germany; D017048:Health Care Costs; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000191:economics* / Q000628:therapy
keywords: Cost; Economic burden; Epilepsy; Status epilepticus