title: Effect of wenxin granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction.
abstract: Aim. To determine the effect of a Chinese herbal compound named Wenxin Granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction (MI). Methods. Male Sprague-Dawley (SD) rats were randomly divided into four groups: the control group, the model group, the metoprolol group, and the Wenxin Granule group (WXKL group) with sample size (n) of 7 rats in each group. An MI model was established in all rats by occlusion of the left anterior descending coronary artery (the control group was without occlusion). Wenxin Granule (1.35 g/kg/day), metoprolol (12 mg/kg/day), and distilled water (5 mL/kg/day for the control and model groups) were administered orally for 4 weeks. Ultrasonic echocardiography was used to examine cardiac structural and functional parameters. Myocardial histopathological changes were observed using haematoxylin and eosin (H&E) dyeing. Myocardial apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining. Serum angiotensin II (Ang II) concentration was measured using the enzyme-linked immunosorbent assay (ELISA). Results. It was found that Wenxin Granule could partially reverse ventricular remodeling, improve heart function, alleviate the histopathological damage, inhibit myocardial apoptosis, and reduce Ang II concentration in rats with MI. Conclusions. The results of the current study suggest that Wenxin Granule may be a potential alternative and complementary medicine for the treatment of MI.
authors.affiliation: Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
authors.forename: Aiming
authors.initials: A
authors.lastname: Wu
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhai
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.forename: Lixia
authors.initials: L
authors.lastname: Lou
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhu
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Gao
authors.forename: Limin
authors.initials: L
authors.lastname: Chai
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Xing
authors.forename: Xiying
authors.initials: X
authors.lastname: Lv
authors.forename: Lingqun
authors.initials: L
authors.lastname: Zhu
authors.forename: Mingjing
authors.initials: M
authors.lastname: Zhao
authors.forename: Shuoren
authors.initials: S
authors.lastname: Wang