title: Estetrol, molecular chaperones, and the epigenetics of longevity and cancer resistance.
abstract: Evidence is given that replicative senescence--possibly as organismal aging--constitutes epigenetic phenomena, counteracted by homeostatic factors such as, e.g., the molecular chaperones, which are housekeeping molecules essential for the folding, repair, and transport of proteins, RNA, and DNA. Weakening of the chaperone defense with age probably contributes to the frailty in senescence. The present review presents evidence that the human fetal estrogen hormone estetrol, by promotion of chaperone functions, homeostasis, and cancer resistance, may prove useful as a supplement during human senescence.
authors.affiliation: Hafnia Unit of Biogerontology , Frederiksberg, Denmark .
authors.forename: Jens
authors.initials: J
authors.lastname: Krøll
mesh_terms: D060467:Disease Resistance / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D004953:Estetrol / Q000494:pharmacology*; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000235:genetics*; D018832:Molecular Chaperones / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics*
chemical_list: D018832:Molecular Chaperones; D004953:Estetrol