title: Sparing effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.
abstract: Robenacoxib is a newer nonsteroidal anti-inflammatory drug approved for dogs and cats. This study was designed to evaluate the effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Sevoflurane MAC-BAR was determined by judging dogs' response to a noxious electrical stimulus (50 V, 50 Hz and 10 msec) for 10 sec in 6 beagle dogs on two occasions at least a 7-day interval. In each occasion, saline (0.1 ml/kg) or robenacoxib (2 mg/kg) was administered subcutaneously at 1 hr prior to the MAC-BAR determination. Robenacoxib significantly decreased the sevoflurane MAC-BAR (3.44 ± 0.53% for saline vs. 2.84 ± 0.38% for robenacoxib, P=0.039). These results suggest that subcutaneous robenacoxib provides a clinically relevant sparing effect on anesthetic requirement.
authors.affiliation: Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Tamura
authors.forename: Takaharu
authors.initials: T
authors.lastname: Itami
authors.forename: Tomohito
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Sho
authors.initials: S
authors.lastname: Fukui
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ooyama
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sano
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D018663:Adrenergic Agents / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D004159:Diphenylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D010092:Oximetry / Q000662:veterinary; D010648:Phenylacetates / Q000494:pharmacology*; D056152:Respiratory Rate / Q000502:physiology; D000077149:Sevoflurane
chemical_list: D018663:Adrenergic Agents; D018685:Anesthetics, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008738:Methyl Ethers; D010648:Phenylacetates; D000077149:Sevoflurane; D004159:Diphenylamine; C551524:robenacoxib