title: Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.
abstract: Insulin/IGF-1 signaling plays a central role in control of cellular metabolism and survival, while insulin receptor substrate (IRS) protein -1 and -2 and downstream PI-3 kinase→Akt→Foxo1 signaling cascade play key roles in many functions of insulin/IGF-1. Dysregulation of this branch of signaling cascades may provide a mechanism for insulin resistance as we observed in cells, animals, and even humans. Targeting this branch of IRS→Foxo1 signaling may provide us with fundamental strategies for drug development in the future.
authors.affiliation: Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, Texas A&M University Health Science Center, Scott & White; Central Texas Veterans Health Care System, Temple, TX 76504, USA.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Guo