title: In vitro and in vivo models for analysis of resistance to anticancer molecular therapies.
abstract: The efficacy of classical and molecular therapies in cancer is hampered by the occurrence of primary (intrinsic) and secondary (acquired) refractoriness of tumours to selected therapeutic regimens. Nevertheless, the increased knowledge of the genetic, molecular and metabolic mechanisms underlying cancer results in the generation of a correspondingly increasing number of druggable targets and molecular drugs. Thus, a current challenge in molecular oncology and medicinal chemistry is to cope with the increased need for modelling, both in cellular and animal systems, the genetic assets associated to cancer resistance to drugs. In this review, we summarize the current strategies for generation and analysis of in vitro and in vivo models, which may reveal useful to extract information on the molecular basis of intrinsic and acquired resistance to anticancer molecular agents.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rosa
authors.forename: Francesca
authors.initials: F
authors.lastname: Monteleone
authors.forename: Nicola
authors.initials: N
authors.lastname: Zambrano
authors.affiliation: Dipartimento di Medicina Clinica e Chirurgia and Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy. robianco@unina.it.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bianco
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents