title: Exogenous hormone use, reproductive history and risk of adult myeloid leukaemia.
abstract: BACKGROUND
  A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.
  
  
  METHODS
  In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.
  
  
  RESULTS
  We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.
  
  
  CONCLUSIONS
  Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.
authors.affiliation: 1] Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, MMC715, 420 Delaware Street S.E., Minneapolis, MN 55455, USA [2] Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Poynter
authors.forename: R
authors.initials: R
authors.lastname: Fonstad
authors.forename: C K
authors.initials: CK
authors.lastname: Blair
authors.forename: M
authors.initials: M
authors.lastname: Roesler
authors.forename: J R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: B
authors.initials: B
authors.lastname: Hirsch
authors.forename: P
authors.initials: P
authors.lastname: Nguyen
authors.forename: J A
authors.initials: JA
authors.lastname: Ross
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017584:Reproductive History; D012306:Risk; D012307:Risk Factors; D055815:Young Adult
chemical_list: D003276:Contraceptives, Oral; D004967:Estrogens