title: Burkitt's lymphoma of the jaws in the Amazon region of Brazil.
abstract: OBJECTIVE
  To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil.
  
  
  METHODS
  Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV).
  
  
  RESULTS
  Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis.
  
  
  CONCLUSIONS
  Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity.
authors.affiliation: Service of Oral Pathology, João de Barros Barreto, University Hospital-Federal, University of Pará, Mundurucus street, n 4877, Zip Code: 66073-000, Belém-Pará-Brazil, flaviapontes@ufpa.br.
authors.forename: Hélder-Antônio
authors.initials: HA
authors.lastname: Rebelo-Pontes
authors.forename: Michelle-Carvalho de
authors.initials: MC
authors.lastname: Abreu
authors.forename: Douglas-Magno
authors.initials: DM
authors.lastname: Guimarães
authors.forename: Felipe-Paiva
authors.initials: FP
authors.lastname: Fonseca
authors.forename: Bruno-Augusto-Benevenuto de
authors.initials: BA
authors.lastname: Andrade
authors.forename: Oslei-Paes de
authors.initials: OP
authors.lastname: Almeida
authors.forename: Décio-dos-Santos
authors.initials: DD
authors.lastname: Pinto Júnior
authors.forename: Flávia-Sirotheau
authors.initials: FS
authors.lastname: Corrêa-Pontes
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002051:Burkitt Lymphoma / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult