title: [Comparative analysis of action of beta-phenyl derivatives of glutamic and gamma-aminobutyric acid on cerebral blood flow and cerebrovascular endothelium after irreversible occlusion of the common carotid artery].
abstract: A comparative analysis of the effect of phenyl derivatives of glutamic (RGPU-135) and gamma-aminobutyric acid (Phenibut) on cerebral blood flow, vasodilatory endothelial function and the number of circulating endothelial cells desquamated in animals after irreversible occlusion of the common carotid arteries. It was found that animals treated prophylactically by RGPU-135, after occlusion of the common carotid arteries have higher cerebral blood flow and lower the severity of endothelial dysfunction than in animals treated with Phenibut.
authors.forename: E V
authors.initials: EV
authors.lastname: Volotova
authors.forename: D V
authors.initials: DV
authors.lastname: Kurkin
authors.forename: N V
authors.initials: NV
authors.lastname: Mazina
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000187:drug effects / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D016019:Survival Analysis; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D020011:Protective Agents; C581791:RGPU-135; D014665:Vasodilator Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid