title: Gardovatine, a novel Strychnos-Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta.
abstract: Gardovatine (1), the first Strychnos-Strychnos alkaloid with a C3/C7 cleaved backbone, was isolated from twigs and leaves of Gardneria ovate, together with an analogue divarine (2). The structure was established by extensive spectroscopic methods. Both compounds showed potential cytotoxicities against five human cancer cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Li
authors.forename: Bao-Hong
authors.initials: BH
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiang-Hai
authors.initials: XH
authors.lastname: Cai
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D007211:Indoles / Q000737:chemistry*; D029541:Loganiaceae / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D031451:Strychnos / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000470:Alkaloids; D026121:Indole Alkaloids; D007211:Indoles; C588139:divarine; C588138:gardovatine; C030374:indole
keywords: Cytotoxicity; Gardneria ovata; Gardovatine