title: Stability of albuterol in continuous nebulization.
abstract: Due to the emergent nature of situations requiring continuous nebulization of albuterol a premixed albuterol solution would provide faster access to the therapy when required. The purpose of this study was to evaluate the stability of albuterol solutions at a concentration (200 micrograms/mL) used in continuous nebulization when stored in various containers of polyvinyl chloride bags, polyolefin bags, polypropylene syringes and tubes and borosilicate glass tubes. Solutions were prepared in triplicate in 0.9% sodium chloride stored under refrigerated and room temperatures for seven days. Samples were removed and analyzed using a stability-indicating high-performance liquid chromatrography assay method. Albuterol was found to be stable (greater than 90% of the initial concentration remaining) for at least seven days in all five types of containers under the conditions tested.
authors.affiliation: College of Pharmacy, University of South Carolina, Columbia, SC.
authors.forename: D A
authors.initials: DA
authors.lastname: Hunter
authors.forename: S D
authors.initials: SD
authors.lastname: Yoo
authors.forename: J L
authors.initials: JL
authors.lastname: Fox
authors.forename: B B
authors.initials: BB
authors.lastname: Michniak