title: "Rolling out" high-molecular-weight proteins, which contain repeating polypeptide motif, by using rolling circle amplification.
abstract: Keep going round in circles: On a circular mRNA template and without an end in sight, E. coli ribosomes have no option but to keep on making a high-molecular-weight polypeptide with repeating units. In this Highlight, the recently published work by Abe and co-workers on this topic is discussed.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, Building 091, College Park, MD 20742 (USA).
authors.forename: Yue
authors.initials: Y
authors.lastname: Zheng
authors.forename: Herman O
authors.initials: HO
authors.lastname: Sintim
mesh_terms: D020816:Amino Acid Motifs; D008970:Molecular Weight; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D010455:Peptides / Q000235:genetics; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D020449:Repetitive Sequences, Amino Acid
chemical_list: D010455:Peptides; D011506:Proteins
keywords: circular mRNA; polypeptides; ribosomal synthesis; rolling circle amplification; tandem repeats