title: Manganese-catalyzed selective oxidation of aliphatic C-H groups and secondary alcohols to ketones with hydrogen peroxide.
abstract: An efficient and simple method for selective oxidation of secondary alcohols and oxidation of alkanes to ketones is reported. An in situ prepared catalyst is employed based on manganese(II) salts, pyridine-2-carboxylic acid, and butanedione, which provides good-to-excellent conversions and yields with high turnover numbers (up to 10 000) with H2 O2 as oxidant at ambient temperatures. In substrates bearing multiple alcohol groups, secondary alcohols are converted to ketones selectively and, in general, benzyl C-H oxidation proceeds in preference to aliphatic C-H oxidation.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen (The Netherlands), Fax: (+31) 50-363-4296.
authors.forename: Jia Jia
authors.initials: JJ
authors.lastname: Dong
authors.forename: Duenpen
authors.initials: D
authors.lastname: Unjaroen
authors.forename: Francesco
authors.initials: F
authors.lastname: Mecozzi
authors.forename: Emma C
authors.initials: EC
authors.lastname: Harvey
authors.forename: Pattama
authors.initials: P
authors.lastname: Saisaha
authors.forename: Dirk
authors.initials: D
authors.lastname: Pijper
authors.forename: Johannes W
authors.initials: JW
authors.lastname: de Boer
authors.forename: Paul
authors.initials: P
authors.lastname: Alsters
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
authors.forename: Wesley R
authors.initials: WR
authors.lastname: Browne
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D000438:Alcohols; D007659:Ketones; D008345:Manganese; D002244:Carbon; D006859:Hydrogen; D006861:Hydrogen Peroxide
keywords: alcohol oxidation; alkane oxidation; catalysis; manganese