title: Prediction of compartment syndrome based on analysis of biochemical parameters.
abstract: BACKGROUND
  The possibility of predicting severe compartment syndrome using simple biochemical parameters was evaluated in a single-center study of 55 patients who presented with acute femoral embolism and who were treated with open surgical embolectomy.
  
  
  METHODS
  Parameters related to tissue damage and oxidative metabolism (i.e., lactate, bilirubin, myoglobin, uric acid, glucose, and fibrinogen) were monitored in ipsilateral femoral vein blood.
  
  
  RESULTS
  Several statistically significant predictors of relevant compartment syndrome after surgical reperfusion were found, including lactate, uric acid, transcutaneous oxygen pressure, bilirubin, intrafascial pressure, and serum myoglobin. Glycemia and serum albumin did not significantly change over time.
  
  
  CONCLUSIONS
  The lactate concentration in femoral vein blood sampled during surgical embolectomy can be used for the stratification of additional postoperative risk of clinically significant compartment syndrome complicating reperfusion after acute embolism of the femoral artery.
authors.affiliation: 2nd Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Mitas
authors.affiliation: Institute of Medical Biochemistry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Vejrazka
authors.affiliation: 2nd Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Hruby
authors.affiliation: 2nd Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Spunda
authors.affiliation: Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Pecha
authors.affiliation: 2nd Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Lindner
authors.affiliation: 2nd Department of Surgery, Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Electronic address: mirekspacek@seznam.cz.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Spacek
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003161:Compartment Syndromes / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D017128:Embolectomy / Q000009:adverse effects*; D004617:Embolism / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005268:Femoral Vein; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000601:surgery*; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D019344:Lactic Acid