title: Reinforced bioresorbable implants for craniomaxillofacial osteosynthesis in pigs.
abstract: Our aim was to design a new bioresorbable fixation device for craniomaxillofacial surgery based on reinforcement of fibres between 2 different polymers. The final device, the 2.8 mm polyglycolide fibre-reinforced-poly-l-lactide screw (PGA FR-PLLA; PLLA/PGA: 70%:30%), was evaluated for its mechanical properties and compared with a commercial resorbable device that was not reinforced with fibre. To model clinical conditions, a unilateral sagittal split ramus osteotomy fixation model in pigs was then used to compare the clinical effectiveness of the resorbable screw with that of a titanium screw in vivo, followed by 3-dimensional reconstructive imaging and histological analysis. Finally, an ex vivo biomechanical test was completed to investigate the immediate fixation stability of the newly designed screws. The PGA FR-PLLA screw resulted in clinical healing that was comparable to that of the titanium screw and was mechanically superior to the commercial device, indicating that the newly-developed screws have a potential clinical application.
authors.affiliation: Craniofacial Research Center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, Taoyuan, Taiwan; Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chih-Hao
authors.initials: CH
authors.lastname: Chen
authors.forename: Victor Bong-Hang
authors.initials: VB
authors.lastname: Shyu
authors.forename: Yi-Chieh
authors.initials: YC
authors.lastname: Chen
authors.forename: Han-Tsung
authors.initials: HT
authors.lastname: Liao
authors.forename: Chun-Jen
authors.initials: CJ
authors.lastname: Liao
authors.forename: Chien-Tzung
authors.initials: CT
authors.lastname: Chen
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D016723:Bone Remodeling / Q000502:physiology; D001863:Bone Screws; D004867:Equipment Design; D005147:Facial Bones / Q000601:surgery*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry; D008334:Mandible / Q000473:pathology / Q000601:surgery; D023421:Models, Animal; D010012:Osteogenesis / Q000502:physiology; D059229:Osteotomy, Sagittal Split Ramus / Q000295:instrumentation / Q000379:methods; D018583:Pliability; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D033081:Shear Strength; D012886:Skull / Q000601:surgery*; D013314:Stress, Mechanical; D013552:Swine; D014025:Titanium / Q000737:chemistry; D014057:Tomography, X-Ray Computed / Q000379:methods; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D014025:Titanium
keywords: Bioresorbable; Craniomaxillofacial surgery; Polyglycolide; Polylactide; Screw