title: Toxicological evaluation of peroxy sulfonated oleic acid (PSOA) in subacute and developmental toxicity studies.
abstract: Peroxy sulfonated oleic acid (PSOA) is a new coupler used in sanitizing solutions primarily for the food and beverage industry. The toxicity of PSOA was evaluated in a 28-day repeat dose study according to OECD 407 guidelines with a 14-day recovery period and a developmental toxicity study according to OECD 414 guidelines. In both studies, PSOA was administered once daily via gavage at 0, 5, 15 and 50 mg/kg/day to Sprague-Dawley rats. Due to its corrosive properties, the highest test concentration was restricted to 0.5%. No findings related to PSOA administration were observed for the 28-day repeat-dose study and the NOEL is 50 mg/kg/day. Additionally, no impairment of the mucous membranes of the gastrointestinal tract was observed up to 0.5%, which is considered the NOEC in terms of local toxicity. For the developmental study, an embryo-fetal NOEL of 50 mg/kg/day was identified and the maternal NOEL is considered to be 15 mg/kg/day, based on slight reductions in maternal body weight and food consumption, as well as a modest increase in the incidence of clinical observations at the high dose. These findings demonstrate that PSOA appears to have minimal potential to induce toxicity associated with repeat-dose or developmental exposures.
authors.affiliation: Ecolab, St. Paul, MN, USA. Electronic address: nathan.pechacek@ecolab.com.
authors.forename: Nathan
authors.initials: N
authors.lastname: Pechacek
authors.forename: Karen
authors.initials: K
authors.lastname: Laidlaw
authors.forename: Stephanie
authors.initials: S
authors.lastname: Clubb
authors.forename: Walter
authors.initials: W
authors.lastname: Aulmann
authors.forename: Magdalena
authors.initials: M
authors.lastname: Osorio
authors.forename: Jeff
authors.initials: J
authors.lastname: Caudill
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced; D000818:Animals; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D020567:Fetal Weight / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D009829:Oleic Acids / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013451:Sulfonic Acids / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods*; D059551:Toxicity Tests, Subacute / Q000379:methods
chemical_list: D009829:Oleic Acids; D013451:Sulfonic Acids; C000590667:peroxy sulfonated oleic acid
keywords: Developmental toxicity; Hydroperoxide; NOEL; PSOA; Peroxy sulfonated oleic acid; Subacute toxicity