title: Evaluation of anti-inflammatory effect of statins in chronic periodontitis.
abstract: OBJECTIVE
  Statins are the group of lipid-lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have potential anti-inflammatory effect by blocking the intermediate metabolites of the mevalonate pathway. The objective of this study was to evaluate the anti-inflammatory effect of statin medication in chronic periodontitis patients.
  
  
  METHODS
  Thirty patients of age group between 40 and 60 years were selected from the outpatient pool of Department of Periodontics, Thaimoogambigai Dental College and Hospital, Chennai. Thirty patients selected were grouped into two groups, Group-I consists of patients with generalized chronic periodontitis and on statin medication and Group-II consists of patients with generalized chronic periodontitis. Clinical parameters were recorded and gingival crevicular fluid (GCF) samples were analyzed for interleukin (IL)-1β using commercially available enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The mean GCF IL-1β levels in generalized chronic periodontitis patients who are on statin medication (Group-I) were lower than the generalized chronic periodontitis patients without statin medication (Group-II).
  
  
  CONCLUSIONS
  Reduction of GCF IL-1β levels in statin users indicate that statins have anti-inflammatory effect on periodontal disease.
authors.affiliation: Department of Periodontology, Thaimoogambigai Dental College and Hospital, Chennai, India.
authors.forename: Snophia
authors.initials: S
authors.lastname: Suresh
authors.forename: Satya
authors.initials: S
authors.lastname: Narayana
authors.forename: P
authors.initials: P
authors.lastname: Jayakumar
authors.forename: Uma
authors.initials: U
authors.lastname: Sudhakar
authors.forename: V
authors.initials: V
authors.lastname: Pramod
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000069059:Atorvastatin; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism; D006538:Heptanoic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D053583:Interleukin-1beta; D011758:Pyrroles; D000069059:Atorvastatin
keywords: Chronic periodontitis; gingival crevicular fluid; interleukin-1β; statins