title: Two new sesquiterpenoids including a sesquiterpenoid lactam from Curcuma wenyujin.
abstract: Two new sesquiterpenoids, namely elema-1,3,7(11),8-tetraen-8,12-lactam (1) and 7β,8α-dihydroxy-1α,4αH-guai-9,11-dien-5β,8β-endoxide (2), together with five known analogs were isolated from the EtOAc extract of the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D-NMR techniques. All compounds were tested for the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Compound 1 showed the significant inhibitory activity with IC50 values of 9.4 µM.
authors.affiliation: School of Pharmacy, Wenzhou Medical University.
authors.forename: Guanguan
authors.initials: G
authors.lastname: Qiu
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Weiwei
authors.initials: W
authors.lastname: Lin
authors.forename: Lianglian
authors.initials: L
authors.lastname: Fang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhao
authors.forename: Jianyong
authors.initials: J
authors.lastname: Dong
mesh_terms: D000818:Animals; D002460:Cell Line; D030024:Curcuma / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D007769:Lactams; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide