title: Novel method for screening of enteric film coatings properties with magnetic resonance imaging.
abstract: The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating. Proposed method involves evaluation of enteric coated model tablets in specially designed testing cell with application of MRI technique. The results obtained in the testing cell were compared with results of dissolution studies of mini-tablets coated in fluid bed apparatus. The method could be useful in early stage of formulation development for screening of film coating properties that will shorten and simplify the development works.
authors.affiliation: Department of Pharmaceutical Technology and Biopharmaceutics, Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688 Krakow, Poland. Electronic address: mfdorozy@cyf-kr.edu.pl.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Dorożyński
authors.forename: Witold
authors.initials: W
authors.lastname: Jamróz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Niwiński
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kurek
authors.forename: Władysław P
authors.initials: WP
authors.lastname: Węglarz
authors.forename: Renata
authors.initials: R
authors.lastname: Jachowicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Kulinowski
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013608:Tablets, Enteric-Coated / Q000737:chemistry*
chemical_list: D013608:Tablets, Enteric-Coated
keywords: Delayed release; Enteric coating; Magnetic resonance imaging (MRI); Mini-tablets; Shellac; Ultra-short echo time imaging (UTE)