title: The hitchhiking effect of a strongly selected substitution in male germline on neutral polymorphism in a monogamy population.
abstract: Comparative genomic studies suggest that a huge number of genes that show the strongest evidence for positive selection in human are testis- or sperm-specific genes, which are possibly due to germline selection. We propose a novel selection model in which the germlines of heterozygous males in a monogamous population are under natural selection. Under this model, we study the dynamics of a strongly selected substitution in the male germline and its hitch-hiking effect on the preexisting linked neutral polymorphism. We show that the expected heterozygosity at the neural locus is reduced by [Formula: see text], where c is the recombination rate between selected and neutral locus, s is selective coefficient of advantageous allele, [Formula: see text] and N is diploid effective population size.
authors.affiliation: Laboratory of Evolutionary Genomics, CAS Key Laboratory of Computational Biology, CAS-MPG Parter Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China ; Graduate School of the Chinese Academy of Sciences, Beijing, China.
authors.forename: Junrui
authors.initials: J
authors.lastname: Li
authors.forename: Kristan A
authors.initials: KA
authors.lastname: Schneider
authors.forename: Haipeng
authors.initials: H
authors.lastname: Li
mesh_terms: D000465:Algorithms; D000483:Alleles; D005787:Gene Frequency; D056084:Genetic Fitness; D006579:Heterozygote; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D013094:Spermatozoa / Q000502:physiology