title: Usual dietary isoflavone intake and reproductive function across the menstrual cycle.
abstract: OBJECTIVE
  To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University.
  
  
  METHODS
  Participants included 259 healthy regularly menstruating women aged 18-44 years.
  
  
  METHODS
  None.
  
  
  METHODS
  Serum concentrations of E2, free E2, P, LH, FSH, and SHBG and sporadic anovulation in healthy premenopausal women.
  
  
  RESULTS
  Isoflavone intake was not associated with E2, free E2, P, LH, and FSH concentrations. Consumption in the highest quartile (Q4: 1.6-78.8 mg/d) was significantly associated with greater SHBG concentrations (β = 0.09; 95% confidence interval [CI] 0.02-0.16), compared with the first quartile (Q1: 0.0-0.3 mg/d).
  
  
  CONCLUSIONS
  Isoflavone intake was not associated with sporadic anovulation (Q4 vs. Q1: odds ratio 0.87, 95% CI 0.32-1.66). Dietary isoflavone intake among young premenopausal women was not related to sex hormone concentrations or anovulation, but was associated with minimally increased SHBG concentrations. These results suggest potential endocrine effects with no subsequent effects on ovulation, easing concerns regarding their impacts on fertility.
authors.affiliation: Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland.
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Filiberto
authors.forename: Sunni L
authors.initials: SL
authors.lastname: Mumford
authors.forename: Anna Z
authors.initials: AZ
authors.lastname: Pollack
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Edwina H
authors.initials: EH
authors.lastname: Yeung
authors.forename: Karen C
authors.initials: KC
authors.lastname: Schliep
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Perkins
authors.forename: Jean
authors.initials: J
authors.lastname: Wactawski-Wende
authors.forename: Enrique F
authors.initials: EF
authors.lastname: Schisterman
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000453:epidemiology* / Q000378:metabolism*; D015331:Cohort Studies; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood* / Q000453:epidemiology*; D004435:Eating; D005260:Female; D047309:Flavones / Q000008:administration & dosage*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects / Q000378:metabolism*; D009518:New York / Q000453:epidemiology; D017697:Premenopause / Q000187:drug effects; D012098:Reproduction; D055815:Young Adult
chemical_list: D047309:Flavones; D012739:Gonadal Steroid Hormones
keywords: Isoflavone; anovulation; nutrition; sex hormones