title: Application of a drug-interaction detection method to the Korean National Health Insurance claims database.
abstract: Drug interactions (DIs) constitute a serious problem and are considered to contribute to 6-30% of all adverse events (AEs). The use of existing data, including claims data, is expected to be helpful in detecting unknown DIs by complementing conventional spontaneous reporting systems. In the present study, an 'Ω shrinkage measure' was applied to the Korean National Health claims database to test the potential of the claims database as a DI surveillance resource. A well-known DI between non-steroidal anti-inflammatory drugs (NSAIDs) and diuretics was analyzed using the model. International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) codes related to DIs were assigned to the AEs of the DIs: I50, I50.0, I50.1, I50.9, R60, R60.1, R60.9, and J81. An elevated occurrence of AEs versus the expected level was observed using a two-sided 95% lower credibility interval limit above zero, Ω025=0.245, which was the screening limit. The result was consistent with the actual DI between the two drugs. The finding indicates that the claims data have the potential to be used as a DI surveillance resource and that the Ω shrinkage measure may be a promising tool for detecting DIs in claims data.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Bldg 17-205, 28, Yeongeon-Dong, Jongno-Gu, Seoul 110-744, South Korea. Electronic address: aamssa04@snu.ac.kr.
authors.forename: Chung Am
authors.initials: CA
authors.lastname: Choi
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Chang
authors.forename: Hye Duck
authors.initials: HD
authors.lastname: Choi
authors.forename: Woo-Young
authors.initials: WY
authors.lastname: Chung
authors.forename: Wan Gyoon
authors.initials: WG
authors.lastname: Shin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D016208:Databases, Factual; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D009313:National Health Programs; D056910:Republic of Korea
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics
keywords: Data mining; Diuretics; Drug interaction; Drug toxicity; Health insurance; NSAIDs