title: Synthesis of dibenzoxepine lactams via a Cu-catalyzed one-pot etherification/aldol condensation cascade reaction: application toward the total synthesis of aristoyagonine.
abstract: A general synthesis of dibenzoxepine lactams has been developed using a one-pot Cu-catalyzed etherification/aldol condensation cascade reaction. The reaction of 4-hydroxyisoindolin-1-one with a wide range of 2-bromobenzaldehydes in the presence of a copper catalyst provided various aristoyagonine derivatives in good yields.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology , 141 Gajeong-ro, Daejeon 305-600 Korea, and Graduate School of New Drug Discovery and Development, Chungnam National University , 99 Daehak-ro, Daejeon 305-764 Korea.
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lim
authors.forename: Young Lok
authors.initials: YL
authors.lastname: Choi
authors.forename: Jung-Nyoung
authors.initials: JN
authors.lastname: Heo
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D001584:Benzoxepins / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001547:Benzaldehydes; D001584:Benzoxepins; D007546:Isoquinolines; D007769:Lactams; C499202:aristoyagonine; D003300:Copper; C116609:3-hydroxybutanal