title: [Reprogramming pancreatic cells to β cells].
abstract: Type 1 diabetes (T1DM) is a common metabolic disorder affecting an ever-increasing number of patients worldwide. T1DM is caused by the selective destruction of pancreatic insulin-producing β-cells by the immune system. Such loss results in chronic hyperglycemia and could induce a number of cardio-vascular complications. Despite the classical insulin-based therapy, compared to healthy people, patients with T1DM display a shortened life expectancy due to the treatment's inability to strictly regulate glycemic levels. An alternative therapy involves pancreatic islet transplantation but the shortage of donors and the required immuno-suppressive treatments limit the widespread use of this approach. Therefore, the search of new approaches to generate functional β-cells is of growing interest. In this review, we describe several novel strategies aiming at the conversion of diverse pancreatic cells into β-cells, such as acinar, ductal, and endocrine cells. Clearly, such promising results could open new research avenues in the context of type 1 diabetes research.
authors.affiliation: Université Nice-Sophia Antipolis, Nice, France.
authors.forename: Andhira
authors.initials: A
authors.lastname: Vieira
authors.forename: Noémie
authors.initials: N
authors.lastname: Druelle
authors.forename: Monica
authors.initials: M
authors.lastname: Courtney
authors.forename: Fabio
authors.initials: F
authors.lastname: Avolio
authors.forename: Nouha
authors.initials: N
authors.lastname: Ben-Othman
authors.forename: Anja
authors.initials: A
authors.lastname: Pfeifer
authors.forename: Elisabet
authors.initials: E
authors.lastname: Gjernes
authors.forename: Biljana
authors.initials: B
authors.lastname: Faurite
authors.forename: Patrick
authors.initials: P
authors.lastname: Collombat
mesh_terms: D061354:Acinar Cells / Q000166:cytology; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery / Q000628:therapy*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000502:physiology; D016381:Islets of Langerhans Transplantation; D010179:Pancreas / Q000166:cytology*; D010183:Pancreatic Ducts / Q000166:cytology; D012038:Regeneration; D014019:Tissue Donors / Q000600:supply & distribution