title: Gastric lavage guided by ultrathin transnasal esophagogastroduodenoscopy in a life-threatening case of tobacco extract poisoning: a case report.
abstract: Nicotine, which is found in tobacco, is one of the most toxic of all known poisons. A 31-year-old woman was brought to our emergency department 2 hours after ingesting a usually fatal dose of a tobacco extract. Although gastric lavage was once commonly used to treat poisoning cases of this type, lavage can lead to such complications as aspiration, hypoxia, oropharyngeal and gastric trauma, and electrolyte disturbances. Recent guidelines have suggested less-aggressive gastric-emptying procedures as initial treatments. Currently, there are no absolute indications for gastric lavage use. The present patient had a history of depressive episodes and had attempted suicide by ingesting an extract derived from 20 cigarettes mixed with alcohol. There was no evidence of vomiting or seizures occurring before arrival of the ambulance. Physical examination revealed no signs of sweating, although the patient appeared to be confused, which is often seen with nicotine intoxication. She admitted using 2 kinds of cigarette, each of which typically contain 11.2 mg of nicotine. The patient's nicotine level was suspected to be higher than 40 to 60 mg, which is normally fatal. To determine whether gastric lavage was indicated in this case, we performed ultrathin transnasal esophagogastroduodenoscopy, which neither requires sedation nor compromises the airways. Although 2 hours had passed since ingestion, the tobacco extract and food were directly visualized within the stomach. Subsequently, gastric lavage was performed with 2,000 mL of water administered through a nasogastric tube. Ultrathin esophagogastroduodenoscopy made it possible to directly observe the gastric lavage and to ensure the stomach contents had been completely removed. No changes were noted in the vital signs, and no obstruction of the airways was observed. The patient recovered quickly and was discharged the following day. Ultrathin esophagogastroduodenoscopy helped determine the diagnosis and ensure that gastric lavage had been performed without complications.
authors.affiliation: Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan. m-masa@nms.ac.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Miyauchi
authors.forename: Makiko
authors.initials: M
authors.lastname: Hayashida
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hirata
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hirata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokota
mesh_terms: D000328:Adult; D016145:Endoscopy, Digestive System; D005260:Female; D005751:Gastric Lavage / Q000379:methods*; D006801:Humans; D009538:Nicotine / Q000506:poisoning*; D010936:Plant Extracts / Q000506:poisoning*; D011041:Poisoning / Q000175:diagnosis / Q000628:therapy; D013406:Suicide, Attempted; D013997:Time Factors; D014026:Nicotiana / Q000506:poisoning*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D009538:Nicotine