title: HBV induced HCC: major risk factors from genetic to molecular level.
abstract: Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.
authors.affiliation: Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Faisalabad 38000, Pakistan.
authors.forename: Ambreen
authors.initials: A
authors.lastname: Ayub
authors.forename: Usman Ali
authors.initials: UA
authors.lastname: Ashfaq
authors.forename: Asma
authors.initials: A
authors.lastname: Haque
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006509:Hepatitis B / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology; D015995:Prevalence; D012307:Risk Factors