title: Development of bioadhesive chitosan superporous hydrogel composite particles based intestinal drug delivery system.
abstract: Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content, in vitro drug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India. hitcvd@yahoo.com
authors.forename: Hitesh
authors.initials: H
authors.lastname: Chavda
authors.forename: Ishan
authors.initials: I
authors.lastname: Modhia
authors.forename: Anant
authors.initials: A
authors.lastname: Mehta
authors.forename: Rupal
authors.initials: R
authors.lastname: Patel
authors.forename: Chhagan
authors.initials: C
authors.lastname: Patel
mesh_terms: D000269:Adhesives / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects*; D007700:Kinetics; D008790:Metoprolol / Q000031:analogs & derivatives; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D048271:Chitosan; D008790:Metoprolol