title: The decline in joint replacement surgery in rheumatoid arthritis is associated with a concomitant increase in the intensity of anti-rheumatic therapy: a nationwide register-based study from 1995 through 2010.
abstract: OBJECTIVE
  Drug-based treatment of rheumatoid arthritis (RA) has evolved markedly over the past 2 decades. Using nationwide register data, we studied how this has affected the rates of hip, knee, shoulder, and elbow replacement from 1995 to 2010.
  
  
  METHODS
  The number of primary joint replacements was obtained from the Finnish Arthroplasty Register. To test the hypothesis that improvements in medical treatment of RA reduce the need for joint replacements, we also collected data about purchases of different disease-modifying anti-rheumatic agents (DMARDs) and biological drugs from the nationwide drug registers.
  
  
  RESULTS
  The annual incidence of primary joint replacements for RA declined from 19 per 10(5) in 1995 to 11 per 10(5) in 2010. The decline was greater for upper-limb operations than for lower-limb operations. At the same time, the numbers of individuals using methotrexate, hydroxychloroquine, and sulfasalazine (the most commonly used DMARDs) increased 2- to 4-fold.
  
  
  CONCLUSIONS
  Our results are in accordance with observations from other countries, and indicate that the use of joint replacements in RA has decreased dramatically. Our data suggest that effective medical therapy is the most likely explanation for this favorable development.
authors.affiliation: Coxa, Hospital for Joint Replacement, Tampere, Finland.
authors.forename: Esa
authors.initials: E
authors.lastname: Jämsen
authors.forename: Lauri J
authors.initials: LJ
authors.lastname: Virta
authors.forename: Markku
authors.initials: M
authors.lastname: Hakala
authors.forename: Markku J
authors.initials: MJ
authors.lastname: Kauppi
authors.forename: Antti
authors.initials: A
authors.lastname: Malmivaara
authors.forename: Matti U K
authors.initials: MU
authors.lastname: Lehto
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000601:surgery; D019643:Arthroplasty, Replacement / Q000706:statistics & numerical data*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D012042:Registries; D012460:Sulfasalazine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D018501:Antirheumatic Agents; D012460:Sulfasalazine; D006886:Hydroxychloroquine; D008727:Methotrexate