title: [Diagnostic value of microtubule-associated protein-2 in small cell lung carcinoma: an analysis of 240 biopsy cases].
abstract: OBJECTIVE
  To investigate the diagnostic value of microtubule-associated protein-2 (MAP-2) in biopsy of small cell lung carcinoma (SCLC).
  
  
  METHODS
  Immunohistochemical technique was applied to detect the expression of synaptophysin (Syn), chromogranin A (CgA), CD56, MAP-2 and TTF-1 in 240 cases of SCLC from 2008 to 2011 in this hospital.
  
  
  RESULTS
  The positive rate of MAP-2 expression in SCLC was 95.8% (230/240), which was much higher than that of Syn (57.1%, 137/240), CgA (38.8%, 93/240) and CD56 (89.2%, 214/240). The sensitivity and accuracy of MAP-2 (99.1%, 95.4%) expression were also higher than those of Syn (58.3%, 42.5%), CgA (39.9%, 42.5%) and CD56 (91.5%, 87.9%).
  
  
  CONCLUSIONS
  MAP-2 is a new neuroendocrine marker with higher sensitivity and accuracy, and thus recommended to be added to the immunohistochemical panel for the diagnosis of SCLC.
authors.affiliation: Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Xiang-hong
authors.initials: XH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D019002:CD56 Antigen / Q000378:metabolism; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D012680:Sensitivity and Specificity; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016708:Synaptophysin / Q000378:metabolism; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019002:CD56 Antigen; D053379:Chromogranin A; C489788:MAP2 protein, human; D008869:Microtubule-Associated Proteins; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D016708:Synaptophysin; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors