title: Shvo's catalyst in chemoenzymatic dynamic kinetic resolution of amines - inner or outer sphere mechanism?
abstract: Evidence is provided for the inner-sphere mechanism with actual metal coordination of the racemic amine in the crucial hydrogen transfer step promoted by Shvo's catalyst of the chemoenzymatic dynamic kinetic resolution (DKR) of amines. Key intermediates involved in this H-transfer step were intercepted and continuously monitored by electrospray ionization mass spectrometry (ESI-MS) and characterized by their dissociation chemistries via ESI-MS/MS.
authors.affiliation: Institute of Chemistry, Federal University of Goiás, Campus Samambaia, Caixa Postal 131, Goiânia, Goiás CEP 74001-970, Brazil.
authors.forename: Boniek G
authors.initials: BG
authors.lastname: Vaz
authors.forename: Cintia D F
authors.initials: CD
authors.lastname: Milagre
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Humberto M S
authors.initials: HM
authors.lastname: Milagre
mesh_terms: D000588:Amines / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000588:Amines; D001596:Benzylamines; D056831:Coordination Complexes; D012428:Ruthenium; C030796:benzylamine