title: Patients with polycythemia vera and essential thrombocythemia with prior malignancy do not have significantly worse outcome.
abstract: The clinical relevance of prior malignancy (PM) in patients with essential thrombocythemia (ET) and polycythemia vera (PV) is largely unknown. We retrospectively evaluated 437 patients (ET, n=263; PV, n=174) treated at MD Anderson between 1960 and 2010. Forty-four patients had PM (ET, 10%; PV, 11%), with median time to diagnosis of 66 months. PM was not associated with abnormal cytogenetics, JAK2-mutation frequency, blood-cell counts or progression to acute leukemia or myelofibrosis. In multivariate analysis, only older age and high LDH levels were associated with worse OS. In conclusion, PM does not predict worse outcomes for patients with ET and PV.
authors.affiliation: Department of Hematology and Oncology, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, OK, USA.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Cherry
authors.forename: Marylou
authors.initials: M
authors.lastname: Cardenas-Turanzas
authors.forename: Hannah
authors.initials: H
authors.lastname: Pham
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
authors.forename: Jorge
authors.initials: J
authors.lastname: Cortes
authors.forename: Sherry
authors.initials: S
authors.lastname: Pierce
authors.forename: Lingsha
authors.initials: L
authors.lastname: Zhou
authors.forename: Srdan
authors.initials: S
authors.lastname: Verstovsek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000401:mortality* / Q000628:therapy; D011087:Polycythemia Vera / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013920:Thrombocythemia, Essential / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D055815:Young Adult
keywords: Essential thrombocythemia; Myeloproliferative disorders; Polycythemia vera; Prior malignancy; Transformation to acute leukemia; Transformation to myelofibrosis