title: Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is a psychiatric disorder whose etiology is not yet known. We investigate the role of three variants of the BDNF gene (rs6265, rs1519480 and rs7124442) by single SNP and haplotype analysis in OCD Mexican patients using a case-control and family-based association design. BDNF gene variants were genotyped in 283 control subjects, 232 OCD patients and first degree relatives of 111 OCD subjects. Single SNP analysis in case-control study showed an association between rs6265 and OCD with a high frequency of Val/Val genotype and Val allele (p=0.0001 and p=0.0001, respectively). Also, genotype and allele analysis of rs1519480 showed significant differences (p=0.0001, p=0.0001; respectively) between OCD and control groups. Haplotype analysis showed a high frequency of A-T (rs6265-rs1519480) in OCD patients compared with the control group (OR=2.06 [1.18-3.59], p=0.0093) and a low frequency of haplotype A-C in the OCD patients (OR=0.04 [0.01-0.16], p=0.000002). The family-based association study showed no significant differences in the transmission of any variant. Our study replicated the association between BDNF Val66Met gene polymorphism and OCD. Also, we found a significant association of rs1519480 in OCD patients compared with a control group, region that has never been analyzed in OCD. In conclusion, our findings suggest that BDNF gene could be related to the development of OCD.
authors.affiliation: Clínica de Trastorno Obsesivo Compulsivo y Trastornos del Espectro, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México DF, Mexico.
authors.forename: Lidia
authors.initials: L
authors.lastname: Márquez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Camarena
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernández
authors.forename: Cristina
authors.initials: C
authors.lastname: Lóyzaga
authors.forename: Luis
authors.initials: L
authors.lastname: Vargas
authors.forename: Humberto
authors.initials: H
authors.lastname: Nicolini
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: Association study; BDNF; Haplotypes; OCD