title: Critical evaluation of biodegradable polymers used in nanodrugs.
abstract: Use of biodegradable polymers for biomedical applications has increased in recent decades due to their biocompatibility, biodegradability, flexibility, and minimal side effects. Applications of these materials include creation of skin, blood vessels, cartilage scaffolds, and nanosystems for drug delivery. These biodegradable polymeric nanoparticles enhance properties such as bioavailability and stability, and provide controlled release of bioactive compounds. This review evaluates the classification, synthesis, degradation mechanisms, and biological applications of the biodegradable polymers currently being studied as drug delivery carriers. In addition, the use of nanosystems to solve current drug delivery problems are reviewed.
authors.affiliation: Unit of Pharmacology, Center of Biodiversity and Drug Discovery, Institute of Scientific Research and High Technology Services, Archaria Nagarjuna University, Guntur, India.
authors.forename: Edgar
authors.initials: E
authors.lastname: Marin
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Briceño
authors.forename: Catherina
authors.initials: C
authors.lastname: Caballero-George
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002460:Cell Line; D004337:Drug Carriers; D004705:Endocytosis; D006801:Humans; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles; D011108:Polymers
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers
keywords: biodegradable polymers; biomedical applications; cellular uptake; drug delivery; nanoparticles