title: [The functional characteristics of hemostasis of full-term and premature newborn according results of thromboflexography].
abstract: The study was carried out using the sample of 40 full-term and 138 premature newborns at 1 - 15th day of live and 20 adult donors. The thromboflexograph TEG 5000 was applied. The study used citrate stabilized venous blood. In full-term newborns the activation of thrombin and fibrin formation (decreasing of constant of coagulation, increasing of velocity of fibrin formation) was detected as compared with adults. In premature newborns shortage of time period of development of reactions of enzyme cascade, shortage of time period of achievement of ultimate amplitude of forming clot and increasing of fibrinolysis were detected as compared with adult donors. The differences in hemostatic system of full-term and premature newborns are characterized by lower functional activity of thrombocytes, decreased strength of forming clots and lower blood coagulation index of premature newborns.
authors.forename: G N
authors.initials: GN
authors.lastname: Kuzmenko
authors.forename: S B
authors.initials: SB
authors.lastname: Nazarov
authors.forename: I G
authors.initials: IG
authors.lastname: Popova
authors.forename: M M
authors.initials: MM
authors.lastname: Klytcheva
authors.forename: N M
authors.initials: NM
authors.lastname: Kharlamova
mesh_terms: D000328:Adult; D000367:Age Factors; D001792:Blood Platelets / Q000378:metabolism; D016022:Case-Control Studies; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D013917:Thrombin / Q000378:metabolism
chemical_list: D005337:Fibrin; D013917:Thrombin