title: Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method.
abstract: BACKGROUND
  Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically used of serum lactate in patients under coronary artery bypass surgery (CABG) by on pump method.
  
  
  METHODS
  From August to September 2012, 15 patients scheduled for routine cardiac surgery entered to our sample and followed up two weeks. Lactate concentration in arterial blood sample was studied. Method of surgery duration of cardiopulmonary bypass, aorta cross clamp timing, hemodynamic parameters, inotrope dosage and patient outcome were documented. The data were collected and analyzed.
  
  
  RESULTS
  The mean age of the patients was 62±14 years. The patients with a poor outcome had significantly higher lactate levels in ABG samples (p<0.001). ABG lactate levels did not correlate with the magnitude of intra-operative bleeding or volume of packed cell transfusion (p>0.05). The PH of ABG samples did not generally correlate with the ABG lactate concentration (r=0.116, p=0.68). Increased lactate concentration was reliably associated with patient hemodynamic parameters, inotrope dosage, duration of on pump time and aorta cross clamp time.
  
  
  CONCLUSIONS
  This study demonstrates a correlation between serum lactate levels and patient prognosis after CABG surgery by on pump method.
authors.affiliation: Department of Anesthesiology and Intensive Care, Golestan University of Medical Sciences, Golestan, Iran. ; Department of Anesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Jabbari
authors.forename: Nadia
authors.initials: N
authors.lastname: Banihashem
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Alijanpour
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Vafaey
authors.forename: Hakimeh
authors.initials: H
authors.lastname: Alereza
authors.forename: Seyed Mozafar
authors.initials: SM
authors.lastname: Rabiee
keywords: Coronary artery bypass graft; Prognosis; Serum lactate