title: Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles.
abstract: A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy.
authors.affiliation: School of Chemistry, University of Manchester , Manchester, M13 9PL, U.K.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Smith
authors.forename: Michael F
authors.initials: MF
authors.lastname: Greaney
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008026:Ligation; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D014230:Triazoles; D015032:Zinc