title: Changes in early serum metal ion levels and impact on liver, kidney, and immune markers following metal-on-metal total hip arthroplasty.
abstract: We retrospectively studied 32 consecutive patients (32 hips) who underwent THA with a Durom large-head, MOM articulation between January 2008 and December 2010. Of the patients who underwent THA using a Trilogy metal on polyethylene prosthesis during the same period, 32 were chosen to form the Trilogy group. 32 volunteers were chosen to form the control group. At the last follow-up, serum metal ion levels, liver and kidney function and host immunologic immune responses were evaluated. The mean Co and Cr levels in the Durom group were 4.33- and 1.95-fold higher than those in the Trilogy group. CD3+, CD4+ and CD8+ cell levels in the Durom group were significantly decreased. The INF-γ level in the Durom group was significantly higher than that in the Trilogy and control groups.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Zhefeng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Weiding
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001672:Biocompatible Materials; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D005260:Female; D006621:Hip Joint; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007107:Immune System / Q000502:physiology; D007477:Ions / Q000097:blood; D007592:Joint Diseases / Q000097:blood* / Q000601:surgery*; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D008297:Male; D008875:Middle Aged; D020959:Polyethylene; D012189:Retrospective Studies; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D015415:Biomarkers; D007477:Ions; D002857:Chromium; D003035:Cobalt; D020959:Polyethylene; D014025:Titanium
keywords: hip arthroplasty; immunity; metal ion; metal-on-metal; metal-on-polyethylene