title: [The dynamics of the immune status indices in conditions of cranio-cerebral trauma on background of a streptozotocin-induced diabetes mellitus in experiment].
abstract: Peculiarities of changes in the immune status in a cranio-cerebral trauma (CCT) on a background of a streptozotocin-induced diabetes mellitus (DM) were studied up. After CCT there are noted the inhibition of predominantly cellular link of immunity, accompanied by reduction of the CD3+ lymphocytes quantity, as well as lymphocytes of the main subpopulations CD4+ and CD8+, CD16+, reduction of the neutrophils phagocytic activity, a complement titer enhancement. Experimental CCT do not cause the essential changes in a CD19+ lymphocytes quantity. The CCT modelling on a background of a streptozotocin-induced DM causes the immune deficiency deepening, in a cellular and humoral links together, significant reduction of activity of a phagocytosis system and complement as well.
authors.forename: V M
authors.initials: VM
authors.lastname: Merets'kyĭ
authors.forename: M M
authors.initials: MM
authors.lastname: Korda
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D015703:Antigens, CD / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D003165:Complement System Proteins / Q000276:immunology; D006259:Craniocerebral Trauma / Q000150:complications / Q000276:immunology* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D018655:Lymphocyte Count; D008297:Male; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D010587:Phagocytosis; D051381:Rats; D013311:Streptozocin
chemical_list: D015703:Antigens, CD; D013311:Streptozocin; D003165:Complement System Proteins