title: Chemical modification, antioxidant and α-amylase inhibitory activities of corn silk polysaccharides.
abstract: Water-soluble corn silk polysaccharides (CSPS) were chemically modified to obtain their sulfated, acetylated and carboxymethylated derivatives. Chemical characterization and bioactivities of CSPS and its derivatives were comparatively investigated by chemical methods, gas chromatography, gel filtration chromatography, scanning electron microscope, infrared spectroscopy and circular dichroism spectroscopy, scavenging DPPH free radical assay, scavenging hydroxyl radical assay, ferric reducing power assay, lipid peroxidation inhibition assay and α-amylase activity inhibitory assay, respectively. Among the three derivatives, carboxylmethylated polysaccharide (C-CSPS) demonstrated higher solubility, narrower molecular weight distribution, lower intrinsic viscosity, a hyperbranched conformation, significantly higher antioxidant and α-amylase inhibitory abilities compared with the native polysaccharide and other derivatives. C-CSPS might be used as a novel nutraceutical agent for human consumption.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
authors.forename: Shuhan
authors.initials: S
authors.lastname: Chen
authors.forename: Haixia
authors.initials: H
authors.lastname: Chen
authors.forename: Jingge
authors.initials: J
authors.lastname: Tian
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Wang
authors.forename: Lisha
authors.initials: L
authors.lastname: Xing
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008970:Molecular Weight; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013552:Swine; D014783:Viscosity; D003313:Zea mays / Q000737:chemistry*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D010851:Picrates; D011134:Polysaccharides; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; D000516:alpha-Amylases; D001205:Ascorbic Acid
keywords: Antioxidant and α-amylase inhibitory properties; Chemical characterization; Chemical modification; Corn silk polysaccharides