title: Comparison of feto-maternal organ derived stem cells in facets of immunophenotype, proliferation and differentiation.
abstract: Scientific explorations on feto-maternal organ stem cells revealed its possible applicability in treatment of various diseases. However, establishment of an ideal placental tissue stem cell source in regenerative application is inconclusive and arduous. Hence, this study aims to resolve this tribulation by comparison of mesenchymal stem cells (MSC) from fetal placenta - amniotic membrane (AM-MSC), chorionic plate (CP-MSC) tissue and the maternal placenta-Decidua (D-MSC), thereby facilitating the researchers to determine their pertinent source. The cells were expanded and scrutinized for expression profiling, proliferation and differentiation ability. Remarkable expressions of certain markers in addition to its prospective mesodermal differentiation confirmed their mesenchyme origin. Despite the specified alikeness among these sources, reliable and non-invasive procurement of AM-MSC coupled with its higher growth potency makes it the most constructive stem cell source. However, exhibited similarities demands further investigations on extensive expandability and cytogenetic stability of these sources prior to its therapeutic applicability.
authors.affiliation: Department of Stem cells, Lifeline Multispeciality Hospital, Chennai, India. Electronic address: indu.stemcell@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Indumathi
authors.forename: R
authors.initials: R
authors.lastname: Harikrishnan
authors.forename: R
authors.initials: R
authors.lastname: Mishra
authors.forename: J S
authors.initials: JS
authors.lastname: Rajkumar
authors.forename: V
authors.initials: V
authors.lastname: Padmapriya
authors.forename: R P
authors.initials: RP
authors.lastname: Lissa
authors.forename: M
authors.initials: M
authors.lastname: Dhanasekaran
mesh_terms: D000650:Amnion / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010920:Placenta / Q000166:cytology; D011247:Pregnancy
keywords: Amniotic membrane; Feto-maternal organ; Immunophenotyping; Mesenchymal stem cells; Placenta