title: Synthesis, antibacterial, antifungal and antitubercular activities of N-pyrazolylbenzamide derivatives.
abstract: A series of new N-pyrazolylbenzamides (5a-x) were synthesized by aroylation of 5-amino-1-phenyl-3-tbutylpyrazole. The structures of synthesized compounds were established based on spectral (FTIR, (1)H NMR, ESI Mass) analysis and purity was ascertained by HPLC. The antibacterial screening revealed that seven molecules exhibited an excellent antibacterial activity and eight compounds demonstrated considerable antifungal activity. Three molecules of the series 5e, 5s and 5w were found to be highly effective against Klebsilla pneumoneia with MIC of 3.12 µg/ml. Compounds 5b, 5f, 5g and 5o exhibited significant antitubercular activity with MIC of 12.5 µg/ml.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Kulkarni
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.forename: Harish
authors.initials: H
authors.lastname: Babu
authors.forename: Krishna
authors.initials: K
authors.lastname: Kumar
authors.forename: Naveen
authors.initials: N
authors.lastname: Gaddam
authors.forename: Aneesa
authors.initials: A
authors.lastname: Fatima
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Muvvala
authors.forename: D V R N
authors.initials: DV
authors.lastname: Bhikshapathi
authors.forename: D
authors.initials: D
authors.lastname: Sriram
authors.forename: Achaiah
authors.initials: A
authors.lastname: Garlapati
authors.forename: Jagrut
authors.initials: J
authors.lastname: Vishnav
authors.affiliation: SVERI's College of Pharmacy, Gopalpur, Pandharpur, Maharashtra State, India. ravigk2000@gmail.com.
authors.forename: Prashant
authors.initials: P
authors.lastname: Gurav
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001549:Benzamides; D011720:Pyrazoles