title: Muscle injury: review of experimental models.
abstract: Skeletal muscle is the most abundant tissue in the human body. Its main characteristic is the capacity to regenerate after injury independent of the cause of injury through a process called inflammatory response. Mechanical injuries are the most common type of the skeletal muscle injuries and are classified into one of three areas strain, contusion, and laceration. First, this review aims to describe and compare the main experimental methods that replicate the mechanical muscle injuries. There are several ways to replicate each kind of mechanical injury; there are, however, specific characteristics that must be taken into account when choosing the most appropriate model for the experiment. Finally, this review discusses the context of mechanical injury considering types, variability of methods, and the ability to reproduce injury models.
authors.affiliation: Research Group in Neuroglial Plasticity, Department of Biochemistry, Institute of Health's Basic Science. Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Course of Physical Therapy, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address: jaquelinesz@yahoo.com.br.
authors.forename: Jaqueline de
authors.initials: Jd
authors.lastname: Souza
authors.forename: Carmem
authors.initials: C
authors.lastname: Gottfried
mesh_terms: D000818:Animals; D003288:Contusions / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D066298:In Vitro Techniques; D022125:Lacerations / Q000503:physiopathology; D008962:Models, Theoretical; D018482:Muscle, Skeletal / Q000293:injuries* / Q000503:physiopathology*; D013180:Sprains and Strains / Q000503:physiopathology; D014949:Wounds, Nonpenetrating / Q000503:physiopathology*
keywords: Contusion and laceration; Mechanical muscle injury; Strain