title: Synthesis of glaucogenin D, a structurally unique disecopregnane steroid with potential antiviral activity.
abstract: The first chemical synthesis of glaucogenin D, a 13,14:14,15-disecopregnane steroid with potential antiviral activity, has been accomplished in 12 steps from a hirundigenin-type intermediate. The present route would also be amenable to the synthesis of natural and unnatural glaucogenin derivatives for SAR studies.
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China.
authors.forename: Jinghan
authors.initials: J
authors.lastname: Gui
authors.forename: Hailong
authors.initials: H
authors.lastname: Tian
authors.forename: Weisheng
authors.initials: W
authors.lastname: Tian
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011278:Pregnanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012328:RNA Viruses / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D011278:Pregnanes; C586608:glaucogenin D