title: Antidepressant-like property of Jobelyn®, an African unique herbal formulation, in mice.
abstract: OBJECTIVE
  The purpose of this investigation was to evaluate whether Jobelyn® (JB) possesses anti-depressant-like property in the mouse forced swimming test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice.
  
  
  METHODS
  Mice were given JB (10-100 mg/kg, p.o.) daily for 7 days and then subjected to FST, TST, YLT and open field test. The parameters assessed in both FST and TST were the time (s) spent in active movement (struggling time), first occurrence of immobility (s) and the duration of immobility (s). In the YLT, the mortality rate was recorded 24 h after yohimbine (35 mg/kg, i.p.) administration. In the open field test, the number of line crosses and total distance travelled (m) were measured for 10 min in the open field chamber.
  
  
  RESULTS
  JB significantly (p<0.05) decrease the duration of immobility both in the FST and TST, which suggests antidepressant-like property. JB significantly (p<0.05) prolonged the time spent in active swimming and delayed the first occurrence of immobility, indicating endurance promoting effect. It potentiated the toxic effect of yohimbine, which further suggests antidepressant-like activity and facilitation of both serotonergic and noradrenergic neurotransmissions. However, JB did not significantly increase the locomotor activity in the open-field test.
  
  
  CONCLUSIONS
  Jobelyn® has antidepressant-like activity, which may be related to the stimulation of serotonergic and noradrenergic pathways. The ability of Jobelyn® to delay the onset of immobility and to prolong the struggling time support its use as energizer in general body weakness or exhaustion.
authors.affiliation: Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.
authors.forename: S
authors.initials: S
authors.lastname: Umukoro
authors.affiliation: Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.
authors.forename: A T
authors.initials: AT
authors.lastname: Eduviere
authors.affiliation: Department of Pharmacology, Osun State University, Osogbo, Nigeria.
authors.forename: A C
authors.initials: AC
authors.lastname: Aladeokin
authors.affiliation: Department of Pharmacology, Osun State University, Osogbo, Nigeria.
authors.forename: A S
authors.initials: AS
authors.lastname: Olugbemide
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019417:Hindlimb Suspension; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013550:Swimming; D013997:Time Factors; D015016:Yohimbine / Q000633:toxicity
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D015016:Yohimbine