title: Influence of cochleostomy and cochlear implant insertion on drug gradients following intratympanic application in Guinea pigs.
abstract: Locally applied drugs can protect residual hearing following cochlear implantation. The influence of cochlear implantation on drug levels in the scala tympani (ST) after round window application was investigated in guinea pigs using the marker trimethylphenylammonium (TMPA) measured in real time with TMPA-selective microelectrodes. TMPA concentration in the upper basal turn of the ST rapidly increased during implantation and then declined due to cerebrospinal fluid entering the ST at the cochlear aqueduct and exiting at the cochleostomy. The TMPA increase was found to be caused by the cochleostomy drilling if the burr tip partially entered the ST. TMPA distribution in the second turn was less affected by implantation procedures. These findings show that basal turn drug levels may be changed during implantation and the changes may need to be considered in the interpretation of therapeutic effects of drugs in conjunction with implantation.
authors.affiliation: Department Otolaryngology, University of Melbourne, Melbourne, Vic., Australia.
authors.forename: E B
authors.initials: EB
authors.lastname: King
authors.forename: J J
authors.initials: JJ
authors.lastname: Hartsock
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Leary
authors.forename: A N
authors.initials: AN
authors.lastname: Salt
mesh_terms: D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000378:metabolism / Q000601:surgery*; D019929:Cochlear Implantation; D003054:Cochlear Implants; D004333:Drug Administration Routes; D006168:Guinea Pigs; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics*; D012533:Scala Tympani / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000644:Quaternary Ammonium Compounds; C009571:phenyltrimethylammonium