title: Esthetic comparison of white-spot lesion treatment modalities using spectrometry and fluorescence.
abstract: OBJECTIVE
  To compare the esthetic improvements of white-spot lesions (WSLs) treated by fluoride, casein phosphopeptide amorphous calcium phosphate (CPP-ACP), or resin infiltration.
  
  
  METHODS
  WSLs were created on human enamel and randomly assigned to four groups: NaF (500 ppm), CPP-ACP, resin infiltration (Icon), or distilled deionized water (DDW; control group). The color change (ΔE) of each specimen was measured with a Crystaleye spectrophotometer, and fluorescence loss (ΔQ) was measured by quantitative light-induced fluorescence (QLF), at different time points after treatment: baseline (0 weeks), 2 weeks, 4 weeks, and 6 weeks.
  
  
  RESULTS
  The ΔE and ΔQ baseline values for the four groups before the treatments did not differ significantly. Icon treatment improved the WSL color significantly and gave the lowest ΔE (2.9 ± 1.2 on average) compared with other treatments (P < .01). The Icon treatment also resulted in a significant change in the ΔQ of WSLs compared with baseline (P < .01). In the NaF and CPP-ACP treatment groups, ΔQ showed significant recovery compared with the baseline values only after 4 weeks after treatment (P < .05).
  
  
  CONCLUSIONS
  Resin infiltration is more effective than NaF or CPP-ACP in providing esthetic improvement of WSLs.
authors.affiliation: a  PhD candidate, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: He
authors.initials: H
authors.lastname: Yuan
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
authors.forename: Richard D
authors.initials: RD
authors.lastname: Cannon
authors.forename: Li
authors.initials: L
authors.lastname: Mei
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use; D003116:Color; D003731:Dental Caries / Q000473:pathology / Q000628:therapy*; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure; D004955:Esthetics, Dental; D005453:Fluorescence; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D055115:Light-Curing of Dental Adhesives / Q000379:methods; D012117:Resins, Synthetic / Q000737:chemistry; D012969:Sodium Fluoride / Q000627:therapeutic use; D013053:Spectrophotometry / Q000379:methods; D013997:Time Factors
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D012117:Resins, Synthetic; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C578177:icon infiltrant; D012969:Sodium Fluoride; D006851:Hydrochloric Acid