title: Impact of exercise training on neuroplasticity-related growth factors in adolescents.
abstract: OBJECTIVE
  We aimed to determine the effect of exercise training on plasma levels of brain-derived neurotrophic factor (BDNF), and serum insulin-like growth factor-1 (IGF-1) as well as cAMP response element-binding (CREB) activation in peripheral blood mononuclear cells (PBMCs) in adolescents.
  
  
  METHODS
  Nine trained and seven sedentary male adolescents, matched in age (14.0±2.2 years), were recruited for the study. Trained boys performed higher physical activity levels (expressed both as total energy expenditure and as physical activity energy expenditure) and showed significant bradycardia when compared with sedentary ones.
  
  
  RESULTS
  We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones. However, no effect of training was found in the activation of CREB in PBMCs.
  
  
  CONCLUSIONS
  We demonstrated the increase of neuroplasticity-related proteins due to exercise training in adolescents. Our results emphasize the significance and impact of exercise in this developmental period.
authors.affiliation: Department of Physiology, Faculty of Medicine and Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, University of Valencia, Av. Blasco Ibañez 15, Valencia, Spain. helios.pareja@uv.es.
authors.forename: H
authors.initials: H
authors.lastname: Pareja-Galeano
authors.forename: T
authors.initials: T
authors.lastname: Brioche
authors.forename: F
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.forename: A
authors.initials: A
authors.lastname: Montal
authors.forename: C
authors.initials: C
authors.lastname: Jovaní
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Costa
authors.forename: M C
authors.initials: MC
authors.lastname: Gomez-Cabrera
authors.forename: J
authors.initials: J
authors.lastname: Viña
mesh_terms: D000293:Adolescent; D056352:Athletes; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D017362:Cyclic AMP Response Element-Binding Protein / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D007334:Insulin-Like Growth Factor I; C579455:BDNF protein, human