title: Neurologic disorders in HIV-positive orphans: 10 years of follow up.
abstract: OBJECTIVE
  Neuropsychic manifestations of AIDS are still noticeable especially in developing countries. The aim of this short communication is to describe psychological, behavioral and neurologic disorders caused by either HIV-related disorders, or drug related toxicities in HIV-infected children from Cambodia (Phnom Penh, Sihanoukville) treated during 10 years with highly active antiretroviral therapy (HAART).
  
  
  METHODS
  One hundred and thirty seven (137) HIV-positive children (age 2-19 years) treated with HAART since 2003 (6-10 years follow up) have been analyzed concerning opportunistic infections, other co-infections, renal parameters, hematologic parameters, chest X-ray, antiretroviral treatment, anti-tuberculotics and antibiotics treatment. We recorded prospectively all data since the start of HAART from 2003-2005 up to December 2012.
  
  
  RESULTS
  Occurrence of drug related neuritis due to stavudine (HAART) was less than 1% and was associated with anti-tuberculous agents accompanying HAART in HIV- and tuberculosis co-infected patients. Co-infections with neurotropic viruses were more frequent: 1 case of CMV retinitis, 18 cases of herpes zoster neuritis and 37 cases of generalized HZV infections (varicella), after onset HAART in children were recorded. All children responded well to anti-viral therapy with ganciclovir (CMV), vanciclovir or acyclovir (HZV) in combination with first line HAART.
  
  
  CONCLUSIONS
  Neurologic disorders in children with HAART are less frequent than in adults. Anti-retrovirals and anti-tuberculosis drugs seem to be safe and less toxic in children then in adults. Co-infections with neurotropic viruses were more frequent, however, were successfully treated with anti-virals.
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Eva
authors.initials: E
authors.lastname: Grey
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Maria
authors.initials: M
authors.lastname: Hardy
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Veronika
authors.initials: V
authors.lastname: Sladeckova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Jana
authors.initials: J
authors.lastname: Adamcova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Bucko
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Juraj
authors.initials: J
authors.lastname: Blaskovic
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Pauerova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Terezia
authors.initials: T
authors.lastname: Dudasova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Polonova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: Lenka
authors.initials: L
authors.lastname: Rabarova
authors.affiliation: St. Maximilian Kolbe Clinic, SEU Tropical program, House of Family, Phnom Penh, Cambodia.
authors.forename: George J
authors.initials: GJ
authors.lastname: Benca