title: Neurochemical evidence for a nigrotegmental GAbAergic projection.
abstract: Axonal transport of [3H]GABA from substantia nigra to the pontomesencephalic tegmentum was demonstrated in rats pretreated with the GABA-transaminase inhibitor, gamma-vinyl-GABA. In addition, kainic acid lesions of substantia nigra resulted in a significant loss of glutamic acid decarboxylase activity in the vicinity of the ipsilateral pedunculopontine nucleus and in adjacent tissue of the pontomesencephalic tegmentum. These data support the thesis that the nigrotegmental projection is both diffuse and GABAergic.
authors.affiliation: Department of Pharmacology, Schools of Medicine and Dentistry, Georgetown University, Washington, DC 20007, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Childs
authors.forename: K
authors.initials: K
authors.lastname: Gale
mesh_terms: D000818:Animals; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018682:GABA Agents / Q000494:pharmacology; D059330:GABAergic Neurons / Q000166:cytology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009434:Neural Pathways; D056347:Neuroanatomical Tract-Tracing Techniques; D045042:Pedunculopontine Tegmental Nucleus / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000166:cytology* / Q000187:drug effects; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000187:drug effects; D014316:Tritium; D020888:Vigabatrin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018682:GABA Agents; D014316:Tritium; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D020888:Vigabatrin; D007608:Kainic Acid