title: Polymorphisms and genetic linkage of histamine receptors.
abstract: Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members of the larger family of rhodopsin-like class A G-protein coupled receptors (GPCRs) (Leurs et al., 2011; Lim et al., 2009). Here, we focus on the genetic variations and polymorphisms localized on the genes encoding for human histamine receptors where it provides an up to date collection of all polymorphisms found on genes encoding the histamine receptor subtypes and their association to diseases.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Stephany
authors.initials: S
authors.lastname: Micallef
authors.forename: Holger
authors.initials: H
authors.lastname: Stark
authors.forename: Astrid
authors.initials: A
authors.lastname: Sasse
mesh_terms: D002493:Central Nervous System Diseases / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011968:Receptors, Histamine / Q000235:genetics*
chemical_list: D011968:Receptors, Histamine
keywords: Diseases; GPCR; Genetic; Histamine; Polymorphism