title: Cytotoxic behavior and spectroscopic characterization of metal complexes of ethylacetoacetate bis(thiosemicarbazone) ligand.
abstract: Reaction of Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) ion with 2,4-dihydrazino-thioamido-1-ethoxybutane led to the formation of mono and binuclear complexes. These complexes have been characterized by elemental analyses, IR, UV-Vis spectra, magnetic moments, molar conductances, (1)H NMR and mass spectra (ligand and its Zn(II) complex), thermal analyses (DTA and TGA) and ESR measurements. The IR data suggest the involvement of sulfur and azomethane nitrogen atoms in coordination to the central metal ion .The Molar conductances of the complexes in DMF are commensurate with their non-ionic character. The ESR spectra of Cu(II) complexes show axial type symmetry (d(x2-y2)) ground state with covalent bond character. On the basis of spectral studies, octahedral or tetrahedral geometry has been assigned to the metal complexes. Complexes have been tested invitro against tumor cells and number of microorganisms in order to assess their antitumor and antimicrobial properties.
authors.affiliation: Chemistry Department, Faculty of Science, Menoufia University, Shebin-El-Kom, Egypt. Electronic address: asaeltabl@yahoo.com.
authors.forename: Abdou Saad
authors.initials: AS
authors.lastname: El-Tabl
authors.forename: Moshira Mohamed Abd
authors.initials: MM
authors.lastname: El-wahed
authors.forename: Ahmed Mahmoud Salah Mahmoud
authors.initials: AM
authors.lastname: Rezk
mesh_terms: D000090:Acetoacetates / Q000737:chemistry* / Q000378:metabolism; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004055:Differential Thermal Analysis; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D013058:Mass Spectrometry; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000090:Acetoacetates; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008670:Metals; D013882:Thiosemicarbazones; C024840:ethyl acetoacetate
keywords: Antimicrobial activity; Antitumor; Magnetism; Metal complexes; Spectral studies