title: Complex atrial arrhythmias as first manifestation of catecholaminergic polymorphic ventricular tachycardia: an unusual course in a patient with a new mutation in ryanodine receptor type 2 gene.
abstract: Catecholaminergic polymorphic ventricular tachycardia is a rare life-threatening arrhythmogenic disorder. An association with paroxysmal atrial fibrillation and other atrial arrhythmias has been described, but in all published cases the initial manifestation of the disease was ventricular arrhythmia. This is the first report about a patient who presented with complex atrial tachycardia and sinus node dysfunction about 1 year before the typical ventricular arrhythmias were observed, leading to the diagnosis of catecholaminergic polymorphic ventricular tachycardia. In this girl, a mutation of the ryanodine receptor type 2 gene, which has not been described so far, was discovered.
authors.affiliation: 1Clinic for Pediatric Cardiology,Congenital Heart Disease,Heart Center Duisburg,Duisburg,Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lawrenz
authors.affiliation: 1Clinic for Pediatric Cardiology,Congenital Heart Disease,Heart Center Duisburg,Duisburg,Germany.
authors.forename: Otto N
authors.initials: ON
authors.lastname: Krogmann
authors.affiliation: 2Clinic for Electrophysiology,Evangelic Hospital Dinslaken,Dinslaken,Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Wieczorek
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000235:genetics; D001282:Atrial Flutter / Q000175:diagnosis* / Q000235:genetics; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009154:Mutation; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics*; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000235:genetics; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel