title: A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model.
abstract: We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.
authors.affiliation: Department of Physics, University of Alberta, Edmonton, AB T6G 2J1, Canada. jackt@ualberta.ca.
authors.forename: Vahid
authors.initials: V
authors.lastname: Rezania
authors.forename: Rebeccah
authors.initials: R
authors.lastname: Marsh
authors.forename: Dennis
authors.initials: D
authors.lastname: Coombe
authors.forename: Jack
authors.initials: J
authors.lastname: Tuszynski
mesh_terms: D004058:Diffusion; D006801:Humans; D008658:Inactivation, Metabolic; D007700:Kinetics; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008954:Models, Biological; D017239:Paclitaxel / Q000378:metabolism / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012212:Rheology
chemical_list: D004364:Pharmaceutical Preparations; D017239:Paclitaxel