title: New insights into von Hippel-Lindau function highlighted by investigation of the trichloroethylene-induced p.P81S hotspot mutation.
authors.affiliation: Affiliations of authors: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD (LN, CJR, WML).
authors.forename: Len
authors.initials: L
authors.lastname: Neckers
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ricketts
authors.forename: W
authors.initials: W
authors.lastname: Marston Linehan
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism*; D017354:Point Mutation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D013724:Teratoma / Q000235:genetics*; D014241:Trichloroethylene / Q000633:toxicity*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051793:Hypoxia-Inducible Factor 1; D025521:Tumor Suppressor Proteins; D014241:Trichloroethylene; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases; C497446:VHL protein, human