title: High-density lipoprotein and prostate cancer: an overview.
abstract: Prostate cancer is a common disease in modern, developed societies and has a high incidence and mortality. High-density lipoprotein cholesterol (HDL-C) has recently received much attention as a possible risk marker of prostate cancer development and prognosis. In the present article, we summarized findings from epidemiologic studies of the association between HDL-C and prostate cancer. Low HDL-C level was found to be a risk and prognostic factor of prostate cancer in several epidemiologic studies, although the overall linkage between HDL and prostate cancer has not been definitively established. The mechanisms for this association remain uncertain; however, limited data from experimental studies imply a possible role of HDL in the pathophysiology of prostate cancer. More epidemiologic research, in combination with experimental studies, is needed in this field.
authors.affiliation: Cardiopulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sekine
authors.forename: Shizukiyo
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Imoh Z
authors.initials: IZ
authors.lastname: Ikpot
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Alan T
authors.initials: AT
authors.lastname: Remaley
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood* / Q000453:epidemiology*; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D008076:Cholesterol, HDL