title: [Expression of pituitary tumor transforming gene in patients with acute lymphoblastic leukemia].
abstract: The aim of this study was to explore the expression of pituitary tumor-transforming gene (PTTG) in acute lymphoblastic leukemia (ALL) and its relationship with the pathogenesis of ALL, as well as study the difference of the PTTG expression in ALL patients with Ph1 chromosome and without Ph1 chromosome. The mRNA expressions of PTTG in bone marrow from 28 patients with ALL and 28 normal controls were quantitatively detected by real-time quantitative polymerase chain reaction (real-time PCR). The results indicated that the expression of PTTG mRNA was significantly higher in ALL patients (1.9428E5 ± 1.8372E5) than that in normal controls (4.5766E3 ± 1.1817E3) (P < 0.05). The expression of PTTG mRNA was higher in Ph1 chromosome positive patients. The initial expression of PTTG mRNA was lower in patients achieved complete remission than that in patients with non-complete remission. It is concluded that the overexpression of PTTG may be related to the progression and genesis of ALL. Overexpression of PTTG may be intimately related to the progression and genesis of Ph1 chromosome positive ALL. It provides a new ideas to research the pathogenesis and genic target treatment of ALL.
authors.affiliation: Department of Hematology, Xiamen University Zhongshan Hospital; Department of Hematology, Fujian Medical University Teaching Hospital, Xiamen 361004, Fajian Province, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Quan-Yi
authors.initials: QY
authors.lastname: Lu
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Niu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Ke-Jie
authors.initials: KJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism; D064249:Securin / Q000235:genetics*; D055815:Young Adult
chemical_list: D064249:Securin; C578002:pituitary tumor-transforming protein 1, human