title: Effects of enamel matrix derivative and basic fibroblast growth factor with μ-tricalcium phosphate on periodontal regeneration in one-wall intrabony defects: an experimental study in dogs.
abstract: This study evaluated the effects of enamel matrix derivative (EMD) and basic fibroblast growth factor (bFGF) with μ-tricalcium phosphate (μ-TCP) on periodontal healing in intrabony defects in dogs. One-wall intrabony defects created in dogs were treated with μ-TCP alone (μ-TCP), EMD with μ-TCP (EMD/μ-TCP), bFGF with μ-TCP (bFGF/μ-TCP), and a combination of each (EMD/bFGF/μ-TCP). The amount of new bone formation was not significant for any group. The EMD/bFGF/μ-TCP group induced significantly greater new cementum formation than the μ-TCP and bFGF/μ-TCP groups and, although not significantly, formed more new cementum than the EMD/μ-TCP group. These findings indicate that EMD/bFGF/μ-TCP treatment is effective for cementum regeneration.
authors.affiliation: Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. syoshi@dent.kagoshima-u.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shirakata
authors.forename: Naoshi
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Taniyama
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Noguchi
mesh_terms: D016301:Alveolar Bone Loss / Q000628:therapy; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology*; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male
chemical_list: D002130:Calcium Phosphates; D003746:Dental Enamel Proteins; D016222:Fibroblast Growth Factor 2; C018392:tricalcium phosphate