title: Clinical course of intoxication with the new anticonvulsant drug perampanel.
abstract: Perampanel has recently been approved as an anticonvulsant drug for focal epilepsies. Phase III trials have shown good tolerability, although data regarding effects of high doses of perampanel are not available. Here, we describe the first case of a 34-year-old patient with perampanel intoxication and attempted suicide, in which the recommended daily dose of perampanel was exceeded ten-fold. Clinical signs of the intoxication and possible psychotropic effects are described.
authors.affiliation: Klinik für Neurologie, RKU, Ulm.
authors.forename: Anselm C
authors.initials: AC
authors.lastname: Hoppner
authors.forename: Susanne
authors.initials: S
authors.lastname: Fauser
authors.forename: Frank
authors.initials: F
authors.lastname: Kerling
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D004828:Epilepsies, Partial / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy / Q000209:etiology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D009570:Nitriles; D011728:Pyridones / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D012640:Seizures / Q000503:physiopathology; D013406:Suicide, Attempted; D014402:Tuberous Sclerosis / Q000150:complications
chemical_list: D000927:Anticonvulsants; D009570:Nitriles; D011728:Pyridones; C551441:perampanel