title: Challenging and complex decisions in the management of the BRCA mutation carrier.
abstract: Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.
authors.affiliation: 1 Division of General Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Daniela L
authors.initials: DL
authors.lastname: Stan
authors.forename: Lynne T
authors.initials: LT
authors.lastname: Shuster
authors.forename: Myra J
authors.initials: MJ
authors.lastname: Wick
authors.forename: Casey L
authors.initials: CL
authors.lastname: Swanson
authors.forename: Sandhya
authors.initials: S
authors.lastname: Pruthi
authors.forename: Jamie N
authors.initials: JN
authors.lastname: Bakkum-Gamez
mesh_terms: D003657:Decision Making; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D009154:Mutation; D010052:Ovariectomy; D011788:Quality of Life; D012307:Risk Factors; D012308:Risk Management; D040242:Risk Reduction Behavior