title: Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands.
abstract: Four new compounds of general formula [FeCp(dppe)L][CF3SO3] with L=imidazole substituted ligands, and dppe=ethylenebis(diphenylphosphane) have been synthesized and characterized with the aim to evaluate their anticancer properties. The new compounds were fully characterized by spectroscopic and electrochemical methods and the structure of [Fe(η(5)-C5H5)(dppe)(1-BuIm)] [CF3SO3] (1), [Fe(η(5)-C5H5)(dppe) (ImH)][CF3SO3] (3) and [Fe(η(5)-C5H5)(dppe)(1HmIm)][CF3SO3] (4) (where 1-BuIm=1-butylimidazole, and 1HmIm=N-hydroxymethylimidazole) was determined by X-ray diffraction studies. Apparently, these compounds are the first reported 'Fe(η(5)-C5H5)' half sandwich derivatives presenting high cytotoxic activity against a set a human tumor cell lines predicting their potential value as antitumor drugs.
authors.affiliation: Centro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Gonçalves
authors.forename: Tânia S
authors.initials: TS
authors.lastname: Morais
authors.forename: M Paula
authors.initials: MP
authors.lastname: Robalo
authors.forename: Fernanda
authors.initials: F
authors.lastname: Marques
authors.forename: Fernando
authors.initials: F
authors.lastname: Avecilla
authors.forename: Cristina P
authors.initials: CP
authors.lastname: Matos
authors.forename: Isabel
authors.initials: I
authors.lastname: Santos
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Tomaz
authors.forename: M Helena
authors.initials: MH
authors.lastname: Garcia
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D058085:Iron Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D003517:Cyclopentanes; D003603:Cytotoxins; D007093:Imidazoles; D058085:Iron Compounds; C029899:imidazole
keywords: Cyclopentadienyl; Cytotoxicity; Heteroaromatic ligands; Iron; Organometallic; X-ray structure