title: The challenges of individualized care for older patients with localized breast cancer.
abstract: Individualized care is achieved when the appropriate screening and/or evaluative tests are used, the treatment plan is driven by evidence-based data and the patient's functional ability, physical and mental health, preference and social situation are incorporated into treatment decisions. Breast cancer is a disease of aging; yet, the management of breast cancer in older women in most cases lacks evidence from prospective randomized clinical trials (i.e., level 1 evidence) to support treatment recommendations. Older women are underrepresented in therapeutic clinical studies, even though studies show that selected fit older women enrolled on clinical trials derive similar benefits as younger women. Very few studies have focused on the distribution and biological behavior of different molecular subtypes of breast cancer in older women making it difficult to conclude whether old age adds extra biological complexity. A comprehensive geriatric assessment that includes a multidimensional process designed to assess functional ability, physical health, cognitive and mental health, social issues and environmental situation of elderly person should be an integral part of individualized care for older patients with breast cancer. However, incorporation of this tool into standard oncology practice is very slow despite the expected steep increase in older individuals with cancer projected over the next 25 years. All of the factors mentioned above hinder progress in delivering individualized care to older patients with breast cancer. This article provides an overview on progress and challenges of individualized and personalized health care in older women with breast cancer.
authors.affiliation: Division of Medical Oncology, The Wexner Medical Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, USA. ewa.mrozek@osumc.edu
authors.forename: Ewa
authors.initials: E
authors.lastname: Mrózek
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Povoski
authors.forename: Charles L
authors.initials: CL
authors.lastname: Shapiro
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D057285:Precision Medicine