title: IL-17 in the rheumatologist's line of sight.
abstract: Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis. Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed.
authors.affiliation: UMR-CNRS 5164, Composantes Innées de la Réponse Immunitaire et de la Différenciation, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux, France. marie-elise.truchetet@chu-bordeaux.fr
authors.forename: Marie-Elise
authors.initials: ME
authors.lastname: Truchetet
authors.forename: M Djavad
authors.initials: MD
authors.lastname: Mossalayi
authors.forename: Katia
authors.initials: K
authors.lastname: Boniface
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020381:Interleukin-17 / Q000378:metabolism*; D053722:Receptors, Interleukin-17 / Q000378:metabolism; D012216:Rheumatic Diseases / Q000276:immunology / Q000628:therapy; D012219:Rheumatology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17