title: ω-3 fatty acid intakes are inversely related to elevated depressive symptoms among United States women.
abstract: Evidence that depressive symptoms are inversely related to n-3 (ω-3) fatty acids is growing among United States adults. We assessed whether self-reported depressive symptoms were inversely associated with n-3 fatty acid intakes by using a cross-sectional study in 1746 adults (aged 30-65 y) in Baltimore City, MD (2004-2009). The 20-item Center for Epidemiologic Studies-Depression Scale (CES-D) was used, with a CES-D score ≥16 suggestive of elevated depressive symptoms (EDS). By using the mean of two 24-h dietary recalls, n-3 highly unsaturated fatty acids (HUFAs; ≥20 carbons), n-3 polyunsaturated fatty acids (PUFAs; ≥18 carbons), and plausible ratios with n-6 (ω6) fatty acids were estimated. EDS prevalence was 18.1% among men and 25.6% among women. In women, the uppermost tertile (tertile 3) of n-3 PUFAs (compared with tertile 1) was associated with reduced odds of EDS by 49%, with a substantial sex differential. The n-3 PUFA:n-6:PUFA ratio was inversely related to EDS among women (tertile 2 vs. tertile 1, OR: 0.74; 95% CI: 0.41, 1.32; tertile 3 vs. tertile 1, OR: 0.47; 95% CI: 0.27, 0.83). A similar pattern was noted for n-3 HUFA:n-6 HUFA among women. For CES-D subscales, n-3 PUFA (% of energy) was inversely related to somatic complaints, whereas positive affect was directly related to n-3 HUFA (% of energy; total population and among women), n-3 HUFA:n-6 HUFA (women), and n-3 HUFA:n-6 PUFA (total population and among women). In sum, among United States women, higher intakes of n-3 fatty acids [absolute (n-3) and relative to n-6 fatty acids (n-3:n-6)] were associated with lower risk of elevated depressive symptoms, specifically in domains of somatic complaints (mainly n-3 PUFAs) and positive affect (mainly n-3 HUFAs).
authors.affiliation: National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD.
authors.forename: May A
authors.initials: MA
authors.lastname: Beydoun
authors.forename: Marie T
authors.initials: MT
authors.lastname: Fanelli Kuczmarski
authors.forename: Hind A
authors.initials: HA
authors.lastname: Beydoun
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Hibbeln
authors.forename: Michele K
authors.initials: MK
authors.lastname: Evans
authors.forename: Alan B
authors.initials: AB
authors.lastname: Zonderman
mesh_terms: D000328:Adult; D000368:Aged; D015142:Baltimore / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D004032:Diet; D004034:Diet Surveys; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D057566:Self Report; D012959:Socioeconomic Factors; D016896:Treatment Outcome
chemical_list: D015525:Fatty Acids, Omega-3