title: Stability of Morphine-Ketamine Mixtures in 0.9% Sodium Chloride Injection Packaged in Syringes, Plastic Bags and MEDICATION CASSETTE Reservoirs.
abstract: The purpose of this study was to determine the stablilty of different intravenous mixtures of morphine and ketamine in 0.9% sodium chloride injection, USP packaged in plastic syringes, plastic bags and MEDICATION CASSETTE reservoirs (SIMS-Deltec, Inc., Minneapolis, MN). Nine morphine (1-,10-,and 25-mg/mL) and ketamine (1-,10-,and 25-mg/mL) mixtures in syringes; two morphine and ketamine mixutres (1 mg/mL and 25 mg/mL of each drug) in plastic bags: and one morpnhine and ketamine mixture (25 mg/mL of each drug) in a MEDICATION CASSETTE reservoir were investigated using a high-performance liquid chromatography analytical technique to measure drug concentrations after one to six days at room temperatue. No loss of drug was observed during the study.
authors.affiliation: Faculte de pharmacie, Universite de Montreal, Montreal, Quebec, Canada.
authors.forename: J J
authors.initials: JJ
authors.lastname: Roy
authors.forename: P
authors.initials: P
authors.lastname: Hildgen