title: Iron/tetramethylethylenediamine-catalyzed ambient-temperature coupling of alkyl Grignard reagents and aryl chlorides.
abstract: Tetramethylethylenediamine (TMEDA) acts as cheap and readily removed ligand in the iron-catalyzed coupling of alkyl Grignard reagents and activated aryl chlorides. The use of TMEDA allows for low ligand and iron catalyst loading as well as an increased reaction concentration and an ambient reaction temperature on a mole scale.
authors.affiliation: Department of Chemistry, University of Warwick , Coventry CV4 7AL, U.K.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rushworth
authors.forename: David G
authors.initials: DG
authors.lastname: Hulcoop
authors.forename: David J
authors.initials: DJ
authors.lastname: Fox
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D005029:Ethylenediamines / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature
chemical_list: D000577:Amides; D004952:Esters; D005029:Ethylenediamines; D006843:Hydrocarbons, Chlorinated; D008024:Ligands; D009942:Organometallic Compounds; C005798:N,N,N',N'-tetramethylethylenediamine; D007501:Iron