title: (18)F-fluoride positron emission tomography measurements of regional bone formation in hemodialysis patients with suspected adynamic bone disease.
abstract: (18)F-fluoride positron emission tomography ((18)F-PET) allows the assessment of regional bone formation and could have a role in the diagnosis of adynamic bone disease (ABD) in patients with chronic kidney disease (CKD). The purpose of this study was to examine bone formation at multiple sites of the skeleton in hemodialysis patients (CKD5D) and assess the correlation with bone biopsy. Seven CKD5D patients with suspected ABD and 12 osteoporotic postmenopausal women underwent an (18)F-PET scan, and bone plasma clearance, K i, was measured at ten skeletal regions of interest (ROI). Fifteen subjects had a transiliac bone biopsy following double tetracycline labeling. Two CKD5D patients had ABD confirmed by biopsy. There was significant heterogeneity in K i between skeletal sites, ranging from 0.008 at the forearm to 0.028 mL/min/mL at the spine in the CKD5D group. There were no significant differences in K i between the two study groups or between the two subjects with ABD and the other CKD5D subjects at any skeletal ROI. Five biopsies from the CKD5D patients had single tetracycline labels only, including the two with ABD. Using an imputed value of 0.3 μm/day for mineral apposition rate (MAR) for biopsies with single labels, no significant correlations were observed between lumbar spine K i corrected for BMAD (K i/BMAD) and bone formation rate (BFR/BS), or MAR. When biopsies with single labels were excluded, a significant correlation was observed between K i/BMAD and MAR (r = 0.81, p = 0.008) but not BFR/BS. Further studies are required to establish the sensitivity of (18)F-PET as a diagnostic tool for identifying CKD patients with ABD.
authors.affiliation: Osteoporosis Unit, Division of Imaging Sciences and Biomedical Engineering, King's College London, Guy's Hospital Campus, Great Maze Pond, London, SE1 9RT, UK, michelle.frost@kcl.ac.uk.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Frost
authors.forename: Juliet E
authors.initials: JE
authors.lastname: Compston
authors.forename: David
authors.initials: D
authors.lastname: Goldsmith
authors.forename: Amelia E
authors.initials: AE
authors.lastname: Moore
authors.forename: Glen M
authors.initials: GM
authors.lastname: Blake
authors.forename: Musib
authors.initials: M
authors.lastname: Siddique
authors.forename: Linda
authors.initials: L
authors.lastname: Skingle
authors.forename: Ignac
authors.initials: I
authors.lastname: Fogelman
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis; D049268:Positron-Emission Tomography / Q000379:methods*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*
chemical_list: D019788:Fluorodeoxyglucose F18