title: A case of DRESS (drug reaction with eosinophilia and systemic symptoms) with acute interstitial nephritis secondary to lenalidomide.
abstract: Acute kidney injury is commonly observed in patients with multiple myeloma and other plasma cell dyscrasias. The pathophysiologic causes, however, are varied. We report a case of a severe 'drug reaction with eosinophilia and systemic symptoms' syndrome associated with acute interstitial nephritis in a patient with multiple myeloma likely related to the administration of lenalidomide. This disease entity requires prompt recognition and cessation of the offending drug and often treatment with high-dose corticosteroids.
authors.affiliation: Department of Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA hamidshaaban@gmail.com.
authors.forename: Hamid
authors.initials: H
authors.lastname: Shaaban
authors.affiliation: Department of Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA.
authors.forename: Trevor
authors.initials: T
authors.lastname: Layne
authors.affiliation: Department of Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA.
authors.forename: Gunwant
authors.initials: G
authors.lastname: Guron
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D000077269:Lenalidomide; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000305:Adrenal Cortex Hormones; D013792:Thalidomide; D000077269:Lenalidomide
keywords: Lenalidomide; drug reaction; nephritis