title: Risperidone-induced acute eosinophilic pneumonia.
abstract: BACKGROUND
  Acute eosinophilic pneumonia (AEP) is a severe syndrome which can be induced for many reasons, including drugs. AEP has rarely been associated with first-generation antipsychotics and never been reported after use of second-generation antipsychotics, such as risperidone.
  
  
  METHODS
  We report a case of a 64-year-old man with a medical history of alchoholism and paranoid symptoms, treated with risperidone at low doses. Following risperidone medication, he presented with respiratory distress. Bronchoalveolar lavage (BAL) specimen was indicated of AEP. All evidence indicated risperidone as the most probable causal factor. The syndrome rapidly resolved after discontinuation of the drug.
  
  
  CONCLUSIONS
  Pathophysiological mechanisms implicated in the development of AEP in our patient seem to be associated with eotaxin and serotonin eosinophilic-specific chemoattracting action, through the serotoninergic action of risperidone.
  
  
  CONCLUSIONS
  To our knowledge, this is the first case report of a clinical adverse reaction of AEP from an atypical antipsychotic agent (risperidone).
authors.affiliation: Second Department of Psychiatry, Medical School, University of Athens, Attikon University General Hospital, Athens, Greece. erizos@med.uoa.gr
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Rizos
authors.forename: Evdoxia
authors.initials: E
authors.lastname: Tsigkaropoulou
authors.forename: Panagiota
authors.initials: P
authors.lastname: Lambrou
authors.forename: Maria
authors.initials: M
authors.lastname: Kanakaki
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Chaniotou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Alevyzakis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
mesh_terms: D000208:Acute Disease; D014150:Antipsychotic Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone
keywords: Risperidone; acute eosinophilic pneumonia; serotonin