title: Solitary fibrous tumor of the thyroid gland.
abstract: Solitary fibrous tumor is a spindle cell neoplasm rarely arising in the thyroid gland. We present a 78-year-old man with the diagnosis of solitary fibrous tumor of the thyroid gland resected by subtotal thyroidectomy. Fine needle aspiration cytology via ultrasound guidance demonstrated a hypocellular aspirate that revealed follicular epithelial cells with mild nuclear atypia and scattered spindle cells with bland nuclei. Histologically, the patternless proliferation of spindle cells was seen among collagenous bundles, accompanied by hemangiopericytomatous vessels, and variously dilated follicles with mild atypical cells having slightly enlarged nuclei, indicating adenomatous goiter. The neoplastic spindle cells showed diffuse immunoreactivity to CD34, bcl-2, CD99 and vimentin, but were negative for cytokeratins, calcitonin, TTF-1 and CD5. Although solitary fibrous tumor arising in thyroid gland is rare, this tumor should be included in the differential diagnosis of thyroid spindle cell tumors and also that of adenomatous.
authors.affiliation: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan, mizuy@med.kyushu-u.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mizuuchi
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kengo
authors.initials: K
authors.lastname: Shirahane
authors.forename: Masae
authors.initials: M
authors.lastname: Souzaki
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008297:Male; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography