title: The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying.
abstract: Transient receptor potential channel ankryn 1 (TRPA1) expressed in the gastrointestinal tract is associated with gastric motility, gastric emptying, and food intake. In this study, we investigated the effects of methyl syringate, a specific and selective TRPA1 agonist, on food intake, gastric emptying, and gut hormone levels in imprinting control region (ICR) mice. The administration of methyl syringate suppressed cumulative food intake and gastric emptying. In addition, treatment with ruthenium red (RR), a general cation channel blocker, and HC-030031, a selective TRPA1 antagonist, inhibited methyl syringate-induced reduction of food intake and delayed gastric emptying in ICR mice. Methyl syringate also increased plasma peptide YY (PYY) levels, but not glucagon-like peptide-1 (GLP-1) levels. The elevation in PYY was blocked by treatment with RR and HC-030031. The present findings indicate that methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.
authors.affiliation: Division of Metabolism and Functionality Research, Korea Food Research Institute, Bundang-gu, Sungnam-si, Gyeonggi-do, South Korea.
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Son
authors.forename: Seo Hyeon
authors.initials: SH
authors.lastname: Song
authors.forename: Myungji
authors.initials: M
authors.lastname: Jung
authors.forename: Yiseul
authors.initials: Y
authors.lastname: Kim
authors.forename: Mee-Ra
authors.initials: MR
authors.lastname: Rhyu
mesh_terms: D000083:Acetanilides / Q000737:chemistry; D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D004396:Coloring Agents / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000494:pharmacology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D007118:Immunoassay; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D019894:Peptide YY / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011687:Purines / Q000737:chemistry; D012430:Ruthenium Red / Q000737:chemistry / Q000494:pharmacology; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels / Q000819:agonists*
chemical_list: C552888:2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide; D000083:Acetanilides; D004396:Coloring Agents; D005768:Gastrointestinal Hormones; D011687:Purines; D000074025:TRPA1 Cation Channel; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse; C506133:methyl syringate; D019894:Peptide YY; D012430:Ruthenium Red; D005707:Gallic Acid; D000171:Acrolein; D052216:Glucagon-Like Peptide 1; C012843:cinnamaldehyde