title: Encapsulating peritoneal sclerosis: case series from a university center.
abstract: OBJECTIVE
  Encapsulating peritoneal sclerosis (EPS) is an often-fatal complication of long-term peritoneal dialysis (PD). We here report the clinical features of EPS in Korean PD patients from a single university center.
  
  
  METHODS
  The data were collected retrospectively from 606 PD patients at Kyungpook National University Hospital, between August 2001 and August 2011. The diagnosis of EPS was based on clinical signs and symptoms, and confirmed by radiological findings.
  
  
  RESULTS
  Eight patients (1.3%, four males) were diagnosed with EPS. The mean age of the patients was 48.5 years (range, 33 to 65). The mean duration of PD was 111.8 months (range, 23 to 186). All patients except for one had three or more episodes of peritonitis. Seven patients were diagnosed with EPS after stopping PD, and only one stayed on PD after initial diagnosis and treatment. Total parenteral nutrition and corticosteroids, in addition to tamoxifen therapy, were used to treat most of the patients, and one patient underwent surgery (adhesiolysis). The overall mortality rate was 50%.
  
  
  CONCLUSIONS
  EPS is a serious, life-threatening complication in patients on long-term PD. To reduce the incidence and mortality rate of EPS, careful monitoring and early diagnosis is needed.
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Kyung-Deuk
authors.initials: KD
authors.lastname: Hong
authors.forename: Ji Hea
authors.initials: JH
authors.lastname: Bae
authors.forename: Yun-Jin
authors.initials: YJ
authors.lastname: Jang
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Jung
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Chan-Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Yong-Lim
authors.initials: YL
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Park
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000401:mortality; D056627:Peritoneal Fibrosis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D056910:Republic of Korea; D012189:Retrospective Studies; D013629:Tamoxifen / Q000627:therapeutic use; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D013629:Tamoxifen
keywords: Peritoneal dialysis; Peritoneal fibrosis; Peritonitis