title: Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and décolletage.
abstract: BACKGROUND
  Mid-dermal injection of stabilized hyaluronic acid (HA) is well established as a treatment to reduce the effects of skin aging.
  
  
  OBJECTIVE
  To assess the efficacy and safety of a stabilized HA-based gel of non-animal origin manufactured using the patented NASHA® technology (Restylane® Vital Light, Q-Med AB, Uppsala, Sweden) administered using a pre-filled micropuncture injector device for rejuvenation of the skin.
  
  
  METHODS
  Three treatment sessions 4 weeks apart were performed on one side of the face, the dorsum of one of the hands and one side of the décolletage, leaving the other side untreated. Skin quality was assessed via blinded live evaluation and subject satisfaction by questionnaire. Aesthetic change was evaluated independently by the subject and a blinded evaluator. Subjects were followed up to week 36.
  
  
  RESULTS
  Thirty subjects aged 40-65 years were enrolled. Overall skin quality across all three treatment areas was judged to be improved on the treated side in over 80% of subjects throughout the study. Significant aesthetic improvements on the treated sides were observed at all visits, with the exception of the décolletage at week 36.
  
  
  CONCLUSIONS
  This was the first study that used a micropuncture injector device for injection of NASHA gel, and reveals that this is a promising treatment option for rejuvenation of the skin.
authors.forename: Meike
authors.initials: M
authors.lastname: Streker
authors.forename: Tilmann
authors.initials: T
authors.lastname: Reuther
authors.forename: Nils
authors.initials: N
authors.lastname: Krueger
authors.forename: Martina
authors.initials: M
authors.lastname: Kerscher
mesh_terms: D000328:Adult; D000368:Aged; D003258:Consumer Behavior; D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D005782:Gels; D006225:Hand; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008845:Microinjections / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D012060:Rejuvenation; D012867:Skin / Q000187:drug effects*; D015595:Skin Aging / Q000187:drug effects*; D012879:Skin Physiological Phenomena; D044465:White People
chemical_list: D005782:Gels; D006820:Hyaluronic Acid; C445361:Restylane