title: Association between serum vaspin level and metabolic syndrome in healthy Korean subjects.
abstract: BACKGROUND
  Visceral obesity is associated with insulin resistance, diabetes, and cardiovascular diseases. Vaspin [visceral adipose tissue (VAT)-derived serpin] may be a novel adipokine related to obesity and its metabolic consequences.
  
  
  OBJECTIVE
  The aim of this study was to investigate the relationships among serum vaspin levels and VAT and the components of metabolic syndrome.
  
  
  METHODS
  A cross-sectional analysis of healthy men (n=97) and women (n=156) for clinical, laboratory, and anthropometric factors was undertaken. Serum vaspin levels were measured. Abdominal VAT and subcutaneous adipose tissue were measured by computed tomography.
  
  
  RESULTS
  Of 253 subjects, 47 (18%) had metabolic syndrome: 33 men (34%) and 14 women (9%). Serum vaspin concentration was significantly lower in men than in women and significantly lower in men with metabolic syndrome than in men without metabolic syndrome. Serum vaspin level tended to decrease with increasing number of metabolic syndrome components, and was negatively correlated with waist circumference, systolic and diastolic blood pressure, serum triglyceride level, and abdominal VAT, but positively correlated with high-density lipoprotein cholesterol level. However, after adjustment for sex, this correlation disappeared.
  
  
  CONCLUSIONS
  Low serum vaspin levels are associated with male gender and metabolic syndrome, particularly in men, and with the majority of metabolic syndrome components.
authors.affiliation: 1 Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Sanggye Paik Hospital, Inje University College of Medicine , Seoul, Republic of Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Tae Nyun
authors.initials: TN
authors.lastname: Kim
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Won
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D000886:Anthropometry; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D056128:Obesity, Abdominal / Q000097:blood; D056910:Republic of Korea; D015843:Serpins / Q000097:blood*; D014057:Tomography, X-Ray Computed
chemical_list: D054392:Adipokines; C507339:SERPINA12 protein, human; D015843:Serpins