title: Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation.
abstract: In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age±SD, 8.5±3.9years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.
authors.affiliation: Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: susanna.esposito@unimi.it.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.forename: Filippo
authors.initials: F
authors.lastname: Salvini
authors.forename: Francesca
authors.initials: F
authors.lastname: Menni
authors.forename: Alessia
authors.initials: A
authors.lastname: Scala
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Salvatici
authors.forename: Francesca
authors.initials: F
authors.lastname: Manzoni
authors.forename: Enrica
authors.initials: E
authors.lastname: Riva
authors.forename: Marcello
authors.initials: M
authors.lastname: Giovannini
authors.forename: Nicola
authors.initials: N
authors.lastname: Principi
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines
keywords: Children; Influenza vaccine; Influenza virus; Metabolic disease; Trivalent influenza vaccine