title: HTLV-1 and leukemogenesis: virus-cell interactions in the development of adult T-cell leukemia.
abstract: Human T-cell lymphotropic virus type 1 (HTLV-1) was originally discovered in the early 1980s. It is the first retrovirus to be unambiguously linked causally to a human cancer. HTLV-1 currently infects approximately 20 million people worldwide. In this chapter, we review progress made over the last 30 years in our understanding of HTLV-1 infection, replication, gene expression, and cellular transformation.
authors.affiliation: Molecular Virology Section, Laboratory of Molecular Microbiology, The National Institutes of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, 20892-0460, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Zane
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D015490:HTLV-I Infections / Q000150:complications* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology*