title: Core-shell Fe3O4 polydopamine nanoparticles serve multipurpose as drug carrier, catalyst support and carbon adsorbent.
abstract: We present the synthesis and multifunctional utilization of core-shell Fe3O4 polydopamine nanoparticles (Fe3O4@PDA NPs) to serve as the enabling platform for a range of applications including responsive drug delivery, recyclable catalyst support, and adsorbent. Magnetite Fe3O4 NPs formed in a one-pot process by the hydrothermal approach were coated with a polydopamine shell layer of ~20 nm in thickness. The as prepared Fe3O4@PDA NPs were used for the controlled drug release in a pH-sensitive manner via reversible bonding between catechol and boronic acid groups of PDA and the anticancer drug bortezomib (BTZ), respectively. The facile deposition of Au NPs atop Fe3O4@PDA NPs was achieved by utilizing PDA as both the reducing agent and the coupling agent. The nanocatalysts exhibited high catalytic performance for the reduction of o-nitrophenol. Furthermore, the recovery and reuse of the catalyst was demonstrated 10 times without any detectible loss in activity. Finally, the PDA layers were converted into carbon to obtain Fe3O4@C and used as an adsorbent for the removal of Rhodamine B from an aqueous solution. The synergistic combination of unique features of PDA and magnetic nanoparticles establishes these core-shell NPs as a versatile platform for multiple applications.
authors.affiliation: Department of Chemical and Biological Engineering and §Princeton Institute for the Science and Technology of Materials, Princeton University , Princeton, New Jersey 08544, United States.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Guo
authors.forename: Gloria
authors.initials: G
authors.lastname: Odusote
authors.forename: Fengli
authors.initials: F
authors.lastname: Qu
authors.forename: Rodney D
authors.initials: RD
authors.lastname: Priestley
mesh_terms: D000327:Adsorption; D001897:Boronic Acids / Q000737:chemistry; D000069286:Bortezomib; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D004337:Drug Carriers; D007211:Indoles; D058185:Magnetite Nanoparticles; D011108:Polymers; D011719:Pyrazines; D012235:Rhodamines; C568283:polydopamine; D014867:Water; D000069286:Bortezomib; D002244:Carbon; C029773:rhodamine B; D052203:Ferrosoferric Oxide