title: A case of possible neurosarcoidosis presenting as intractable headache and panhypopituitarism.
abstract: Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosarcoidosis without systemic involvement is extremely rare. We present a case of suspicious neurosarcoidosis affecting the pituitary gland, which was manifested as chronic uncontrolled headache, panhypopituitarism, central diabetes insipidus, and hypercalcemia. Though the biopsy at the pituitary lesion was not performed due to the high risk of surgical complication, treatment was needed urgently and we started steroid therapy. After steroid therapy, we observed the immediate symptom relief with improved hypercalcemia. According to the follow-up examination, no recurrent symptom was seen, and resolution of the pituitary lesion with improving panhypopituitarism was noted.
authors.affiliation: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, No. 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Hwang
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Cho
authors.forename: So Young
authors.initials: SY
authors.lastname: Park
authors.forename: Jung Il
authors.initials: JI
authors.lastname: Son
authors.forename: Uk
authors.initials: U
authors.lastname: Jo
authors.forename: Sang Ouk
authors.initials: SO
authors.lastname: Chin
authors.forename: Yun Jung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Moon Chan
authors.initials: MC
authors.lastname: Choi
authors.forename: Sang Youl
authors.initials: SY
authors.lastname: Rhee
authors.forename: Eui Jong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Suk
authors.initials: S
authors.lastname: Chon