title: [Analysis of the role of neurohumoral systems in action of dopaminomimetic dopamine on ion-regulating renal function].
abstract: Dopamine causes in anesthetized rats expressed diuretic response that is accompanied by an increase in GRF and a significant enhance of sodium and potassium excretion. Pretreatment the animals in diclofenac sodium or contrical in doses, that inhibit respectively activity of renal PG-system and kallikrein-kinin system, don't prevent of renal effects of dopamine. Preliminary assignment a direct renin inhibitor aliskiren enhances the diuretic, natriuretic and kaliyuretic effects of the drug. It is concluded that renal PG-system and kallikrein-kinin system are not involved in the formation of renal effects of dopamine. Renal tissue RAS directly included in the mechanism of action of dopamine in the kidney, acting as a modulator, preventing excessive loss of water and electrolytes with urine.
authors.forename: L N
authors.initials: LN
authors.lastname: Landar'
authors.forename: O B
authors.initials: OB
authors.lastname: Kuz'min
mesh_terms: D000577:Amides / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D007611:Aprotinin / Q000494:pharmacology; D002414:Cations, Monovalent; D004008:Diclofenac / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D005650:Fumarates / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D017136:Ion Transport / Q000187:drug effects; D016234:Kallikrein-Kinin System / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
chemical_list: D000577:Amides; D002414:Cations, Monovalent; D005650:Fumarates; D004008:Diclofenac; C446481:aliskiren; D007611:Aprotinin; D012964:Sodium; D011188:Potassium; D004298:Dopamine