title: [Fast onset of action of sublingual immunotherapy in dust mite caused allergic rhinoconjunctivitis].
abstract: OBJECTIVE
  To investigate whether sublingual immunotherapy(SLIT) can take effect during the early phase in allergic rhinoconjunctivitis.
  
  
  METHODS
  Sixty subjects diagnosed as allergic rhinoconjunctivitis were enrolled and divided into the SLIT group and the control group. The daily symptom and medication scores were recorded and analyzed.
  
  
  RESULTS
  After 4 weeks treatments, the daily symptoms score had significantly reduced in SLIT group(P<0. 05). After 6, 8, 10 weeks treatments, the daily symptoms scores of subjects in the SLIT group had all shown continuous reduction, with no consumption of medication. The comparison between daily symptom score at 4th week and those in 6th week or 8th week or 10th week in the SLIT group had shown no significant difference (all P > 0.05). Whereas, the daily symptoms score and daily medication score in control group had shown changes with fluctuations. The correlation analysis had indicated that the daily medication score in the control group had a significant negative correlation with the daily symptom score (F = 554.9, P < 0.01). No serious adverse events occurred in this study.
  
  
  CONCLUSIONS
  SLIT could take effect in patients with allergic rhinoconjunctivitis sensitive to house dust mite as fast as the 4th week.
authors.affiliation: Department of Otorhinolaryngology, Qiaotou Hospital of Dongguan, Guangdong Province, Dongguan, 523523, China. huangzhonghua009@163.com
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Huang
authors.forename: Yumei
authors.initials: Y
authors.lastname: Liu
authors.forename: Huifen
authors.initials: H
authors.lastname: Luo
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003233:Conjunctivitis, Allergic / Q000209:etiology / Q000628:therapy*; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D039981:Pyroglyphidae / Q000276:immunology; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology / Q000628:therapy*; D055815:Young Adult
chemical_list: D000485:Allergens