title: [Adult Gianotti-Crosti syndrome caused by hepatitis B].
abstract: A 42-year-old man was admitted to our hospital with a lower extremity rash, general fatigue, and abdominal discomfort. Laboratory findings revealed elevated serum transaminases as well as positivity for the hepatitis B surface antigen and the immunoglobulin M type anti-hepatitis B core antibody. He was diagnosed with a rash typical of Gianotti-Crosti syndrome due to acute infection with hepatitis B virus, genotype A. After admission, the rash gradually decreased; however, serum transaminases and jaundice increased. Entecavir therapy was initiated on day 11 of admission, and his liver function subsequently improved over two weeks. Gianotti-Crosti syndrome is rarely seen in adult patients. It may be important to pay attention to the typical rash of Gianotti-Crosti syndrome because it may provide an important clue to an otherwise asymptomatic acute hepatitis B infection.
authors.affiliation: Department of Internal Medicine, Saiseikai Central Hospital.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Iwasaki
authors.forename: Maiko
authors.initials: M
authors.lastname: Takita
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kishino
authors.forename: Motoko
authors.initials: M
authors.lastname: Izumiya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
mesh_terms: D000169:Acrodermatitis / Q000209:etiology*; D000208:Acute Disease; D000328:Adult; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008297:Male