title: Emerging therapeutic options in GERD.
abstract: Gastroesophageal reflux disease (GERD) is a prevalent problem resulting in a high level of healthcare consultation and expenditure in the Western World. Although standard medical therapy (in the form of proton pump inhibitor drugs) is effective in the majority of cases, there remains a significant proportion who are refractory to treatment. In addition, surgical therapy (in the form of laparoscopic fundoplication) is not always effective, and in some can be associated with significant side-effects, particularly gas-bloat, flatulence and dysphagia. As such there remains an unmet need in GERD to develop new therapies for refractory cases, and to develop alternatives to fundoplication with fewer side-effects. This article discusses the current state of pharmacological and non-pharmacological emerging therapies for GERD.
authors.affiliation: Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Woodland
authors.forename: Gehanjali
authors.initials: G
authors.lastname: Amarasinghe
authors.forename: Daniel
authors.initials: D
authors.lastname: Sifrim
mesh_terms: D003680:Deglutition Disorders / Q000601:surgery; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors
keywords: Endoscopic GERD therapy; Gastroesophageal reflux disease; Reflux inhibitors; Refractory disease; Visceral hypersensitivity