title: Asymmetric Michael-aldol tandem reaction of 2-substituted benzofuran-3-ones and enones: a facile synthesis of griseofulvin analogues.
abstract: A highly enantioselective Michael-aldol tandem reaction with respect to prochiral 2-substituted benzofuran-3-ones and enones by a facile primary amine catalyst was investigated. The approach provides rapid access to the desired pharmaceutically active griseofulvin analogues.
authors.affiliation: State-key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University , Tianjin 300071, P. R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Dong
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006118:Griseofulvin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D001572:Benzofurans; D013141:Spiro Compounds; D006118:Griseofulvin; C116609:3-hydroxybutanal