title: Fast determination of aldehyde preservatives by miniaturized capillary electrophoresis with amperometric detection.
abstract: A novel miniaturized CE with amperometric detection (mini-CE-AD) method has been developed for fast determination of aliphatic aldehyde preservatives, namely formaldehyde and glyoxal, in commodities. After derivatization with an electroactive compound 2-thiobarbituric acid, these two nonelectroactive aldehydes were converted to electroactive adducts, therefore detectable by mini-CE-AD approach. Under the optimum conditions, two aldehydes can be well-separated with the coexisting interferents as well as their homologs (acetaldehyde and methyl-glyoxal), and the LODs (S/N = 3) were achieved at nanogram-per-milliliter level (1.64-2.80 ng/mL) based on the online enrichment method of transient moving chemical reaction boundary. The proposed method has been applied for the analyses of above aldehyde preservatives in different real commodity samples including skincare products, baby lotion, and toothpaste, and the average recoveries were in the range of 94-105%, which should find a wide range of analytical applications as an alternative to conventional and microchip CE approaches.
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Ge
authors.forename: Fanghong
authors.initials: F
authors.lastname: Tong
authors.forename: Zhaoyue
authors.initials: Z
authors.lastname: Deng
authors.forename: Fengwu
authors.initials: F
authors.lastname: Shen
authors.forename: Qianxia
authors.initials: Q
authors.lastname: Gu
authors.forename: Jiannong
authors.initials: J
authors.lastname: Ye
authors.forename: Qingcui
authors.initials: Q
authors.lastname: Chu
mesh_terms: D000447:Aldehydes / Q000032:analysis*; D003358:Cosmetics / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000295:instrumentation* / Q000379:methods*; D057230:Limit of Detection; D016014:Linear Models; D008904:Miniaturization / Q000295:instrumentation*; D011310:Preservatives, Pharmaceutical / Q000032:analysis*; D015203:Reproducibility of Results
chemical_list: D000447:Aldehydes; D003358:Cosmetics; D011310:Preservatives, Pharmaceutical
keywords: 2-Thiobarbituric acid derivatization; Aldehyde preservative; Miniaturized CE; Moving chemical reaction boundary; Online enrichment