title: Development of chitosan-based nanoparticles through inter-polymeric complexation for oral drug delivery.
abstract: The possibility of inter-polymeric complexation of cationic chitosan and anionic egg albumin stabilized with PEG 400 to develop novel nanoparticles for oral delivery of alprazolam by heat coagulation method at pH 5.4 and 80 °C. Nine formulations were prepared by changing the concentration of chitosan, PEG 400 and heating time. The alprazolam entrapment efficiency of these nanoparticles was in the range of 68.12±1.27 to 99.37±4.86%. These nanoparticles were characterized by FTIR, DSC, P-XRD and FE-SEM analysis. Average particle diameter, poly-dispersity index and zeta potential of these nanoparticles were found 259.60 nm, 0.501, and -9.00 mV, respectively. The in vitro drug release from these alprazolam-loaded nanoparticles showed sustained drug release over a period of 24h. In conclusion, these newly developed chitosan-egg albumin-PEG nanoparticles were found to be a promising vehicle for sustained release delivery of lipophilic drugs.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, West Bengal, India. janapharmacy@rediffmail.com
authors.forename: Sougata
authors.initials: S
authors.lastname: Jana
authors.forename: Nirmal
authors.initials: N
authors.lastname: Maji
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: Kalyan Kumar
authors.initials: KK
authors.lastname: Sen
authors.forename: Sanat Kumar
authors.initials: SK
authors.lastname: Basu
mesh_terms: D000284:Administration, Oral; D000418:Albumins / Q000737:chemistry*; D000525:Alprazolam / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D006358:Hot Temperature; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D000418:Albumins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011092:Polyethylene Glycols; D048271:Chitosan; D000525:Alprazolam
keywords: Alprazolam; Chitosan; Drug delivery; Nanoparticles; Sustained release