title: [The connection of polymorphism I/D of the gene angiotensin-converting ferment and D442G gene of protein-carrier of cholesterol ethers with atherosclerosis risk factors in patients of elderly and senile age with coronary heart disease in the Republic Sakha (Yakutia)].
abstract: The authors analyse allocation of genotypes frequencies of polymorphism I/D of the gene of angiotensin-converting ferment (ASYA) and D442G gene of protein-transmitting agent of cholesterol ethers (CETP) in patients of elderly, senile age and long-livers with coronary heart disease taking into account their nationality, age and sex. With the age, the frequency reduction of occurrence of genotype ACE*I/*I has been observed and there is a tendency to increase of genotype frequency ACE*D/*D. Sexual distinctions in frequency of revealing of homozygous genotype ACE*D/*D have been revealed at the relative analysis of genotypes ACE*D/*D and ACE*D/*I. The carriers of genotype ACE*D/*D significantly more are males than females. In the general group (especially in the group of Yakuts), the carriers of genotype ACE*I/*I have demonstrated significantly more often the hypertrophy of myocardium of the left ventricle, which is accurately reflected with the help of ECG sign of Sokolov-Lion. While studying the polymorphism D442G of the gene CETP, the carriers of genotype CETP:D*/*G are significantly more often met among Yakuts, than non-indigenous population. The comparison of genotypes frequencies I/D-polymorphism of the gene ACE have showed reliable distinctions of BBI, indexes of blood lipids. The comparison of genotypes CETP*D/*D, CETP*D/*G has not yielded authentic connection with risk factors of coronary heart disease.
authors.forename: N S
authors.initials: NS
authors.lastname: Arkhipova
authors.forename: A L
authors.initials: AL
authors.lastname: Ar'ev
authors.forename: E K
authors.initials: EK
authors.lastname: Popova
authors.forename: L V
authors.initials: LV
authors.lastname: Grigor'eva
authors.forename: L S
authors.initials: LS
authors.lastname: Kozina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics*; D002352:Carrier Proteins / Q000097:blood / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D004987:Ethers / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012426:Russia
chemical_list: D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D004987:Ethers; D004247:DNA; D007703:Peptidyl-Dipeptidase A