title: Method validation for simultaneous determination of chromium, molybdenum and selenium in infant formulas by ICP-OES and ICP-MS.
abstract: This study aimed to validate the analytical method for simultaneous determination of chromium (Cr), molybdenum (Mo), and selenium (Se) in infant formulas available in South Korea. Various digestion methods of dry-ashing, wet-digestion and microwave were evaluated for samples preparation and both inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS) were compared for analysis. The analytical techniques were validated by detection limits, precision, accuracy and recovery experiments. Results showed that wet-digestion and microwave methods were giving satisfactory results for sample preparation, while ICP-MS was found more sensitive and effective technique than ICP-OES. The recovery (%) of Se, Mo and Cr by ICP-OES were 40.9, 109.4 and 0, compared to 99.1, 98.7 and 98.4, respectively by ICP-MS. The contents of Cr, Mo and Se in infant formulas by ICP-MS were found in good nutritional values in accordance to nutrient standards for infant formulas CODEX values.
authors.affiliation: Department of Food and Nutrition, Chosun University, Gwangju 501-759, Republic of Korea.
authors.forename: Naeem
authors.initials: N
authors.lastname: Khan
authors.forename: In Seon
authors.initials: IS
authors.lastname: Jeong
authors.forename: In Min
authors.initials: IM
authors.lastname: Hwang
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Choi
authors.forename: Eun Yeong
authors.initials: EY
authors.lastname: Nho
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Choi
authors.forename: Byung-Man
authors.initials: BM
authors.lastname: Kwak
authors.forename: Jang-Hyuk
authors.initials: JH
authors.lastname: Ahn
authors.forename: Taehyung
authors.initials: T
authors.lastname: Yoon
authors.forename: Kyong Su
authors.initials: KS
authors.lastname: Kim
mesh_terms: D002857:Chromium / Q000032:analysis*; D041943:Infant Formula / Q000737:chemistry*; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000379:methods*; D008982:Molybdenum / Q000032:analysis*; D056910:Republic of Korea; D012643:Selenium / Q000032:analysis*
chemical_list: D002857:Chromium; D008982:Molybdenum; D012643:Selenium
keywords: Analytical method; Chromium; Infant formulas; Korea; Molybdenum; Selenium