title: Microfluidics for nano-pathophysiology.
abstract: Nanotechnology-based drug delivery systems hold promise for innovative medical treatment of cancers. While drug materials are constantly under development, there are no practical cell-based models to assess whether these materials can reach the target tissue. Recently developed microfluidic systems have revolutionized cell-based experiments. In these systems, vascular endothelial cells and interstitium are set in microchannels that mimic microvessels. Drug permeability can be assayed in these blood vessel models under fluidic conditions that mimic blood flow. In this review, we describe device fabrication, disease model development, nanoparticle permeability assays, and the potential utility of these systems in the future.
authors.affiliation: Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, Bunkyo, Tokyo 112-8681, Japan. Electronic address: satouk@fc.jwu.ac.jp.
authors.forename: Kae
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Toyo University, Kawagoe, Saitama 350-8585, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sasaki
authors.affiliation: Division of Proteomics and Nanobiotechnology, Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
authors.forename: Helene Andersson
authors.initials: HA
authors.lastname: Svahn
authors.affiliation: Division of Molecular Science, Faculty of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan.
authors.forename: Kiichi
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics; D008954:Models, Biological
keywords: Cardiovascular model; Disease model; Microdevice; Microfluidics; Organs on a Chip