title: The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells.
abstract: We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract of T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously. When cells were treated with the hot water extract of T. fuciformis prior to β-amyloid peptide treatment (active domain of A peptide 25~35 treated), toxicity was significantly diminished (p<0.01). These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.
authors.affiliation: Institute of Food & Culture R&D Center, Pulmuone Co., Ltd., Seoul 120-600, Korea.
authors.forename: Kum Ju
authors.initials: KJ
authors.lastname: Park
authors.forename: Sang-Yun
authors.initials: SY
authors.lastname: Lee
authors.forename: Hyun-Su
authors.initials: HS
authors.lastname: Kim
authors.forename: Matsumi
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Kenzo
authors.initials: K
authors.lastname: Chiba
authors.forename: Hyo-Cheol
authors.initials: HC
authors.lastname: Ha
keywords: Neuroprotective effect; Neurotrophic effect; PC12h cell; Tremella fuciformis