title: Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide.
abstract: Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.
authors.affiliation: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02139, USA.
authors.forename: Su Ryon
authors.initials: SR
authors.lastname: Shin
authors.forename: Behnaz
authors.initials: B
authors.lastname: Aghaei-Ghareh-Bolagh
authors.forename: Tram T
authors.initials: TT
authors.lastname: Dang
authors.forename: Seda Nur
authors.initials: SN
authors.lastname: Topkaya
authors.forename: Xiguang
authors.initials: X
authors.lastname: Gao
authors.forename: Seung Yun
authors.initials: SY
authors.lastname: Yang
authors.forename: Sung Mi
authors.initials: SM
authors.lastname: Jung
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Oh
authors.forename: Mehmet R
authors.initials: MR
authors.lastname: Dokmeci
authors.forename: Xiaowu Shirley
authors.initials: XS
authors.lastname: Tang
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D000818:Animals; D002470:Cell Survival; D005780:Gelatin / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D008853:Microscopy; D041681:NIH 3T3 Cells; D010087:Oxides / Q000737:chemistry; D016062:Porosity; D023822:Tissue Engineering; D014466:Ultraviolet Rays
chemical_list: D020100:Hydrogels; D010087:Oxides; D006108:Graphite; D005780:Gelatin
keywords: graphene; microgels; multilayer constructs; tissue engineering; tunable stiffness