title: Detection of gastric cancer with Fourier transform infrared spectroscopy and support vector machine classification.
abstract: Early diagnosis and early medical treatments are the keys to save the patients' lives and improve the living quality. Fourier transform infrared (FT-IR) spectroscopy can distinguish malignant from normal tissues at the molecular level. In this paper, programs were made with pattern recognition method to classify unknown samples. Spectral data were pretreated by using smoothing and standard normal variate (SNV) methods. Leave-one-out cross validation was used to evaluate the discrimination result of support vector machine (SVM) method. A total of 54 gastric tissue samples were employed in this study, including 24 cases of normal tissue samples and 30 cases of cancerous tissue samples. The discrimination results of SVM method showed the sensitivity with 100%, specificity with 83.3%, and total discrimination accuracy with 92.2%.
authors.affiliation: School of Instrumentation Science and Opto-Electronics Engineering, Precision Opto-Mechatronics Technology Key Laboratory of Education Ministry, Beihang University, Haidian District, Beijing, China. qblee@126.com
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ling
authors.forename: Jin Guang
authors.initials: JG
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D060388:Support Vector Machine
chemical_list: D014408:Biomarkers, Tumor