title: [Pharmacokinetics and tissue distribution of irinotecan hydrochloride nanoparticles].
abstract: To investigate the pharmacokinetics of irinotecan hydrochloride (CPT-11) in rats and the tissue distribution of CPT-11 in mice after injection of irinotecan hydrochloride nanoparticles (CPT-11 NPs) via tail veins, separately, a LC-MS/MS method was established to determine the concentration of CPT-11 in whole blood of rats and in different tissues of mice. The pharmacokinetics and tissue distribution of CPT-11 were compared after the intravenous injection of CPT-11 NPs and CPT-11 solution. Compared with CPT-11 solution, the elimination half-life of CPT-11 was prolonged from 2.28 h to 3.95 h after the intravenous injection of CPT-11 NPs, and its AUC was 1.47 times than that of CPT-11 solution. After the injection of CPT-11 NPs in mice, the concentrations of CPT-11 loaded in CPT-11 NPs were significantly higher in the whole blood, colon and lungs than those in CPT-11 solution, but lower in the spleen, liver, kidney and heart, but the least in brain. CPT-11 NPs could improve CPT-11 's AUC, and help CPT-11 to reach long circulation activity.
authors.affiliation: School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Fu-Ying
authors.initials: FY
authors.lastname: Yang
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Zhang
authors.forename: He-Li
authors.initials: HL
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Fu
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Wang
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Wei
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Yang
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Zhang
authors.forename: Hong-Wan
authors.initials: HW
authors.lastname: Dang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007275:Injections, Intravenous; D000077146:Irinotecan; D008297:Male; D051379:Mice; D053758:Nanoparticles; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin