title: Pharmacological strategy for overcoming opioid-induced ventilatory disturbances.
abstract: Opioids are among the most frequently used analgesics for treatment of severe pain. However, certain of their side-effects, particularly ventilatory disturbances, often restrict their use. Separation of analgesia from respiratory depression has long been a goal in the basic research and therapeutic use of opioids. This report briefly describes opioid-induced respiratory depression and possible pharmacological strategies to counteract this without affecting analgesia.
authors.affiliation: Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Kimura
authors.affiliation: Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan. Electronic address: haji@dpc.agu.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Haji
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects*; D000818:Animals; D006801:Humans; D011957:Receptors, Opioid / Q000378:metabolism; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000701:Analgesics, Opioid; D011957:Receptors, Opioid
keywords: Cholinesterase inhibitor; Methylxanthine; Opioid; Phosphodiesterase inhibitor; Respiratory depression; Serotonergic agonist