title: [Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].
abstract: OBJECTIVE
  To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.
  
  
  METHODS
  Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.
  
  
  RESULTS
  Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).
  
  
  CONCLUSIONS
  Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.
authors.affiliation: School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. pjingli@163.com
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Li
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zeng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Mo
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage*; D015519:Bone Density / Q000187:drug effects; D003374:Coumarins / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001572:Benzofurans; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D004958:Estradiol; C102768:psoralidin