title: And then there were none: no need for pluripotency factors to induce reprogramming.
abstract: While most factors used as reprogramming transgenes can be replaced by other means, Oct4 has remained essential until now. Three recent papers have now broken this barrier through the use of opposing lineage specifying transgenes and chemical modulation, thus signifying a milestone in advancing our understanding of pluripotency induction.
authors.affiliation: Stem Cell Program in the Institute for Cell Engineering and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Bin-Kuan
authors.initials: BK
authors.lastname: Chou
authors.forename: Linzhao
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000818:Animals; D054337:Cell Dedifferentiation; D060846:Cell Engineering / Q000379:methods*; D065150:Cellular Reprogramming / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology*; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D054852:Small Molecule Libraries; D014157:Transcription Factors