title: Biology of the estrogen receptor, GPR30, in triple negative breast cancer.
abstract: BACKGROUND
  Triple-negative (TN) breast cancer lacks a known signaling pathway amenable to targeted therapy. The authors hypothesized that the G protein-coupled receptor GPR30 may be present in TN breast cancer and serve a role for tumor growth.
  
  
  METHODS
  A retrospective pathology study and chart review were conducted. All patients aged ≤49 years from 2000 to 2008 were included (n = 24). Concurrent patients aged ≥50 years were randomly selected. Paraffin sections were stained for GPR30 and reviewed by a pathologist blinded to estrogen receptor and progesterone receptor status. Disease-free survival was analyzed versus age and receptor status. Means were compared using 2-sample t tests and proportions using chi-square analysis.
  
  
  RESULTS
  Twenty-seven patients tested GPR30 positive and 21 GPR30 negative. Seventeen of 18 TN cancers tested positive for GPR30 (P < .0001). Recurrence at a mean follow-up of 36 months was 22.2% in the GPR30-positive group and 9.5% in the GPR30-negative group.
  
  
  CONCLUSIONS
  GPR30 is prevalent in TN breast cancer and associated with young age and possibly recurrence.
authors.affiliation: Department of Surgery, Southern Illinois University School of Medicine, Carbondale, IL, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Steiman
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Peralta
authors.forename: Somaja
authors.initials: S
authors.lastname: Louis
authors.forename: Onsi
authors.initials: O
authors.lastname: Kamel
mesh_terms: D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012189:Retrospective Studies; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C109584:GPER1 protein, human; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: Estrogen receptor; G protein–coupled receptor; Prognosis; Triple-negative breast cancer