title: Hydrogen-rich saline ameliorates the retina against light-induced damage in rats.
abstract: Oxidative reactions are thought to be a major cause of light-induced retinal degeneration. This study was designed to investigate the effects of hydrogen-rich saline (HRS) on the prevention and treatment of light-induced retinal injury in rats. Male Sprague-Dawley rats were divided randomly into three groups: light damage, HRS prevention (5 ml/kg, 30 min before intensive light exposure), and HRS treatment (5 ml/kg per day for 5 days, after intensive light exposure), respectively. The right eye of each rat was exposed to 5000 lux constant white light-emitting diode (LED) light for 3 h, and the left eye was covered to serve as the blank control. Electroretinograms were recorded 5 days later, and the thickness of the outer nuclear layer (ONL) was measured after hematoxylin and eosin (H&E) staining. The results showed that the electroretinogram b-wave amplitudes and the mean ONL thicknesses of rats were significantly greater in the HRS prevention (P < 0.001) and treatment (P < 0.001) groups than in the light damage. These results indicated that peritoneal injection of HRS provides protection and treatment against light-induced retinal degeneration in rats.
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xia
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Yashino
authors.initials: Y
authors.lastname: Sugita
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the National Education Ministry, Fourth Military University, 17 Changle West Road, Xi'an 710032, China.
authors.forename: Zuoming
authors.initials: Z
authors.lastname: Zhang