title: Fahr's disease: bilateral symmetrical striopallidodentate calcification in two brothers with two distinct presentations.
abstract: Bilateral striopallidodentate calcinosis, commonly known as Fahr's disease is a rare clinical entity present mainly with extrapyramidal signs and accompanied with metabolic, biochemical, neuroradiological and neuropsychiatric situations. It is characterised by the symmetrical and bilateral intracranial deposition of calcium associated with cell loss in the basal ganglia, cerebral cortex and cerebellum.In this study, we discussed two brothers' cases of Fahr's diseases who presented with different symptomatology. The first presented with walking difficulty, cramps and dysarthria and moderate memory impairment whereas the second with vertigo, ataxia, forgetfulness and headache. CT scans of both patients revealed intracranial diffuse bilateral calcifications in the basal ganglia and the cerebellum. The second patient revealed progressive cerebral atrophy but reduction in the calcification. Fahr's disease, although encountered rarely, should also be taken into account in the differential diagnosis of cases with abnormal intracranial calcifications along with other familial, congenital and metabolic diseases and syndromes.
authors.affiliation: Department of Neuroscience, EMMS Nazareth Hospital, Nazareth, Israel.
authors.forename: Abdalla
authors.initials: A
authors.lastname: Bowirrat
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yassin
authors.forename: Faozi
authors.initials: F
authors.lastname: Artoul
authors.forename: Suheil
authors.initials: S
authors.lastname: Artul
mesh_terms: D001480:Basal Ganglia Diseases / Q000175:diagnosis*; D002114:Calcinosis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000175:diagnosis*; D035781:Siblings