title: Creatinine-based equation to estimate the glomerular filtration rate in Japanese children and adolescents with chronic kidney disease.
abstract: BACKGROUND
  Renal inulin clearance is the gold standard for evaluation of kidney function, but cannot be measured easily in children. Therefore, we utilize the serum creatinine (Cr)-based estimated GFR (eGFR) measuring serum Cr by the enzymatic method, and we have reported simple serum Cr-based eGFR in Japanese children aged between 2 and 11 years old. Furthermore, we should use serum Cr-based eGFR in Japanese adolescents as well as children with chronic kidney disease for evaluation of renal function.
  
  
  METHODS
  The inulin clearance and serum Cr level determined by an enzymatic method were measured in 131 pediatric chronic kidney disease (CKD) patients between the ages of 2 and 18 years old with no underlying disease affecting renal function except CKD to determine the serum Cr-based eGFR in Japanese children and adolescents.
  
  
  RESULTS
  We offer the complex estimated GFR equation using polynomial formulae for reference serum creatinine levels with body length in Japanese children except infants, resulting in the following equation:[Formula: see text] Reference serum Cr levels (y) are shown by the following two equations of body length (x):[Formula: see text]
  
  
  CONCLUSIONS
  The new polynomial eGFR formula showing the relationship with body length and serum Cr level may be applicable for clinical screening of renal function in Japanese children and adolescents aged between 2 and 18 years.
authors.affiliation: Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, Obu, Aichi, 474-8710, Japan, o_uemura@hkg.odn.ne.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Uemura
authors.forename: Takuhito
authors.initials: T
authors.lastname: Nagai
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishikura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hataya
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Gotoh
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akioka
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Kaneko
authors.forename: Masataka
authors.initials: M
authors.lastname: Honda
mesh_terms: D000293:Adolescent; D000367:Age Factors; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin; D007564:Japan / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology*; D016014:Linear Models; D008954:Models, Biological; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D007444:Inulin; D003404:Creatinine