title: [MicroRNA-193b expression in newly diagnosed leukemia patients and its significance].
abstract: This study was aimed to quantitatively detect the levels of microRNA-193b (miR-193b) in leukemia patients and explore its significance. Real time fluorescent quantitative PCR was used to detect the relative expression level of miR-193b. The expression changes of miR-193b in various types of leukemia were analyzed. Then the relationship among miR-193b expression, parts of laboratory index and the response to chemotherapy was analyzed as well. The results showed that miR-193b expression level in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) patients was not lower than that in normal group (P > 0.05). Except for APL, miR-193b expression level in acute myeloid leukemia (AML) patients was lower than that in normal group (P < 0.05). In AML (except for APL) patients, there was no correlation between white blood cell count (P > 0.05), the expression of CD34 (P > 0.05) and miR-193b expression level, but there was negative correlation between chemotherapy response and miR-193b expression level (P < 0.05). It is concluded that miR-193b expression level may be correlated with susceptibility of cells to chemotherapy in AML (except for APL) patients. miR-193b maybe become a new target in AML (except for APL) therapy.
authors.affiliation: Department of Transfusion, Fujian Medical University Union Hospital; Fujian Institute of Hematology, Fuzhou 350001, Fujian Province, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Fan
authors.forename: Hao-Bo
authors.initials: HB
authors.lastname: Huang
authors.forename: Jian-Zhen
authors.initials: JZ
authors.lastname: Shen
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Fu
authors.forename: Hua-Rong
authors.initials: HR
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D014019:Tissue Donors; D055815:Young Adult
chemical_list: C546818:MIRN193 microRNA, human; D035683:MicroRNAs