title: Exosomes function in cell-cell communication during brain circuit development.
abstract: Exosomes are small extracellular vesicles that mediate intercellular signaling in the brain without requiring direct contact between cells. Although exosomes have been shown to play a role in neurological diseases and in response to nerve trauma, a role for exosome-mediated signaling in brain development and function has not yet been demonstrated. Here we review data building a case for exosome function in the brain.
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
authors.forename: Pranav
authors.initials: P
authors.lastname: Sharma
authors.forename: Lucio
authors.initials: L
authors.lastname: Schiapparelli
authors.forename: Hollis T
authors.initials: HT
authors.lastname: Cline
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D009434:Neural Pathways / Q000254:growth & development* / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*