title: [Clinical study of 62 patients with symptoms of male climacterium].
abstract: We prospectively reviewed the records of 62 patients who had sought evaluation at our hospital with a chief complaint of male climacteric symptoms. Late-onset hypogonadism (LOH)-related symptoms were evaluated during the initial visit based on the Aging Males' Symptoms (AMS) score, International Index of Erectile Function (IIEF) -5 score, and Center for Epidemiologic Studies Depression Scale (CES-D). Laboratory and endocrinologic testing, including the free testosterone (FT) level, was performed with blood samples collected before 10 : 00 am. The AMS psychological and CES-D scores in patients with a FT ＞8.5 pg/ml were significantly higher than those in patients with a FT ≦8.5 pg/ml. The study included 32 patients who were diagnosed with LOH (FT ≦8.5 pg/ml) and treated with androgen replacement therapy (ART). The total, somatic, psychological, and sexual scores of the AMS were significantly decreased after the third intramuscular administration of testosterone enanthate; there were no serious complications. Because a significant proportion of depressed patients may be amongst the patients with aging male's symptoms, it is important to consider depression in the exclusion diagnosis during a clinical examination for LOH.
authors.affiliation: The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Japan.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Hori
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nishii
authors.forename: Satoru
authors.initials: S
authors.lastname: Masui
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshio
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Kanda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamada
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Arima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sugimura
mesh_terms: D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use; D047649:Andropause / Q000502:physiology*; D003863:Depression / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D013739:Testosterone