title: Effect of orally administered Lactobacillus brevis HY7401 in a food allergy mouse model.
abstract: We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
authors.affiliation: Laboratory of Immunology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Jieun
authors.initials: J
authors.lastname: Bang
authors.forename: Hee-Jong
authors.initials: HJ
authors.lastname: Woo
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004032:Diet / Q000379:methods*; D004195:Disease Models, Animal; D005512:Food Hypersensitivity / Q000276:immunology / Q000628:therapy*; D052196:Levilactobacillus brevis / Q000254:growth & development / Q000502:physiology*; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000276:immunology*; D019936:Probiotics / Q000008:administration & dosage*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000485:Allergens; D016207:Cytokines; D010047:Ovalbumin