title: Molecular inclusion complex of curcumin-β-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel.
abstract: Curcumin (CUR) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. Therefore, transdermal application has become a potential alternative to delivery CUR. To increase CUR solubility for the development of a transparent homogenous gel and also enhance the permeation rate of CUR into the skin, β-cyclodextrin-curcumin nanoparticle complex (BCD-CUR-N) was developed. CUR encapsulation efficiency was increased by raising the percentage of CUR to BCD up to 20%. The mean particle size of the best CUR loading formula was 156 nm. All evaluation data using infrared spectroscopy, Raman spectroscopy, powder X-ray diffractometry, differential thermal analysis and scanning electron microscopy confirmed the successful formation of the inclusion complex. BCD-CUR-N increased the CUR dissolution rate of 10-fold (p < 0.01). In addition, the improvement of CUR permeability acrossed skin model tissue was observed in gel containing the BCD-CUR-N and was about 1.8-fold when compared with the free CUR gel (p < 0.01). Overall, CUR in the form of the BCD-CUR-N improved the solubility further on the penetration of CUR.
authors.affiliation: School of Pharmacy, Bandung Institute of Technology, Ganesha 10, Bandung, 40132, Indonesia, hrachma@yahoo.com.
authors.forename: Heni
authors.initials: H
authors.lastname: Rachmawati
authors.forename: Citra Ariani
authors.initials: CA
authors.lastname: Edityaningrum
authors.forename: Rachmat
authors.initials: R
authors.lastname: Mauludin
mesh_terms: D000818:Animals; D017821:Boidae; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000737:chemistry* / Q000493:pharmacokinetics*; D004055:Differential Thermal Analysis; D004058:Diffusion; D004563:Electrochemistry; D005782:Gels; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010316:Particle Size; D012869:Skin Absorption; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D005782:Gels; D047392:beta-Cyclodextrins; D003474:Curcumin