title: The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF).
abstract: OBJECTIVE
  To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone.
  
  
  METHODS
  Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use.
  
  
  RESULTS
  438 participants (initial age 9-13 years (mean 11.1±0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean ΔQ (mm(2)%), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the ΔQ values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant (p<0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months.
  
  
  CONCLUSIONS
  The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China.
authors.forename: W
authors.initials: W
authors.lastname: Yin
authors.forename: D Y
authors.initials: DY
authors.lastname: Hu
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhang
authors.forename: I A
authors.initials: IA
authors.lastname: Pretty
authors.forename: L R
authors.initials: LR
authors.lastname: Mateo
authors.forename: D
authors.initials: D
authors.lastname: Cummins
authors.forename: R P
authors.initials: RP
authors.lastname: Ellwood
mesh_terms: D000293:Adolescent; D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005453:Fluorescence; D005459:Fluorides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008027:Light; D008297:Male; D010710:Phosphates / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D010710:Phosphates; C585805:pro-argin; D012969:Sodium Fluoride; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides
keywords: Arginine; Arrest; Caries; Dentifrice; Enamel; Fluoride; Lesions; Reversal