title: Asialoglycoprotein receptor-targeted radiopharmaceuticals for measurement of liver function.
abstract: The number of Asialoglycoprotein (ASGP) receptors on the hepatocytes of patients with liver disease is reduced and is thus considered a good indicator for the evaluation of liver function. ASGP receptor-targeted radiopharmaceuticals permit a non-invasive way to evaluate total and regional hepatic function and hepatic functional reserve visually and quantitatively. Over the past three decades, a variety of ASGP receptor-targeted probes have been developed with different molecular backbones (albumin, polymer, small-molecular-weight ligand), different glycol-residues (galactose, lactose, N-acetyl-galactosamine) and different chelating systems suitable for radiolabeling with SPECT isotopes ((99m)Tc, (111)In, (67)Ga, (131/125)I, (153)Sm) and PET isotopes ((68)Ga, (18)F). In this review, we present an overview of ASGP receptor-targeted radiopharmaceuticals, discuss their chemistry, biodistribution, catabolism and challenge as well as application for measurement of liver function.
authors.affiliation: Research Center for Application of Nuclear Technology, Institute of High Energy Physics, 19B YuquanLu, Shijingshan District, Beijing, 100049, P. R. China. yuliu@ihep.ac.cn.
authors.forename: W
authors.initials: W
authors.lastname: Yang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000378:metabolism*; D006801:Humans; D008111:Liver Function Tests / Q000379:methods*; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism; D008970:Molecular Weight; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037263:Asialoglycoprotein Receptor; D015335:Molecular Probes; D019275:Radiopharmaceuticals