title: Topical and biologic therapies for diabetic foot ulcers.
abstract: Chronic DFUs are a growing global health concern due to the implied high rates of morbidity and mortality. Standard-of-care modalities sometimes are not sufficient for some recalcitrant ulcers. The use of adjuvant topical therapies including advanced dressings and biologic therapies should be considered in patients whose DFU did not reduce in size after receiving standard care for a period of 4 weeks. These advanced treatments must be used in combination with standard care measures, including debridement, moist wound healing, offloading, and infection control.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Richmond
authors.forename: Alejandra C
authors.initials: AC
authors.lastname: Vivas
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001458:Bandages; D003094:Collagen / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods*; D017719:Diabetic Foot / Q000188:drug therapy / Q000628:therapy*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000890:Anti-Infective Agents; D003094:Collagen
keywords: Biologic therapies; Diabetic foot ulcers; Topical antiseptics; Wound care