title: Resistin levels are related to fat mass, but not to body mass index in children.
abstract: The relationship of resistin levels with obesity remains unclear. The aim of this study was to determine resistin levels in prepubertal children and adolescents and evaluate their association with anthropometric parameters and body composition. The study population included 420 randomly selected 6-8-year-old children and 712 children aged 12-16 years. Anthropometric data were measured and body mass index (BMI) and waist-to-hip and waist-to-height ratios were calculated. Body composition was assessed using an impedance body composition analyzer. Serum resistin levels were determined using a multiplexed bead immunoassay. Resistin levels were not significantly different between sexes. No significant differences in serum resistin concentrations were found between obese, overweight, and normal weight children at any age, and no significant correlations were observed between resistin concentrations and weight or BMI. However, resistin levels showed a significant positive correlation with fat mass in 12-16-year-old children, particularly in girls. In addition to describing serum resistin levels in prepubertal children and adolescents, our study suggests that resistin is related to body fat rather than to BMI in adolescents.
authors.affiliation: Lipid Research Laboratory, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Ortega
authors.forename: Pía
authors.initials: P
authors.lastname: Riestra
authors.forename: Pilar
authors.initials: P
authors.lastname: Navarro
authors.forename: Teresa
authors.initials: T
authors.lastname: Gavela-Pérez
authors.forename: Leandro
authors.initials: L
authors.lastname: Soriano-Guillén
authors.forename: Carmen
authors.initials: C
authors.lastname: Garcés
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009929:Organ Size; D052243:Resistin / Q000378:metabolism*
chemical_list: C499624:RETN protein, human; D052243:Resistin
keywords: BMI; Body mass index; Children; Fat mass; NW; OW; Resistin levels; body mass index; normal-weight; overweight