title: [Photo-activity of actinomycins].
abstract: Using actinomycins as an example, the possibility of increasing the anti-tumor activity of heterocyclic antibiotics due to photo-activation, has been studied. In model experiments with solutions of actinomycins, it was showed that actinomycins have a significant photochemical activity (of its own), changing by the binding to DNA in solution or in tumor cells. Photo-destruction of HeLa cells and the release of the antibiotic were observed.
authors.forename: N L
authors.initials: NL
authors.lastname: Vekshin
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004273:DNA, Neoplasm / Q000737:chemistry / Q000378:metabolism; D003609:Dactinomycin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000378:metabolism; D055668:Photochemical Processes
chemical_list: D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D003609:Dactinomycin