title: [The comparative value of quantiferonic test, neopterin and specific anti-tuberculosis antibodies in clinical diagnostic of tuberculosis of lungs].
abstract: The article deals with comparison of clinical diagnostic value of laboratory techniques of tuberculosis. The sample included 63 patients with tuberculosis of lungs. 49 persons of long-time contact with patients with tuberculosis and 28 healthy donors. The QuantiFERON-TB Gold In-Tube test was applied to total sampling. The content of neopterin and specific anti-tuberculosis antibodies in blood plasma was determined. According study data, the mentioned test is mostly informative for detection of tuberculosis contamination (sensitivity 64%, specificity 89%). However, the obvious shortcoming of this technique is the fact that it can't provide the differentiation between active and latent tuberculosis infection. As opposed to QuantiFERON-TB Gold In-Tube test, the detection of specific anti-tuberculosis antibodies (sensitivity 54%, specificity 94%) and neopterin (sensitivity 51%, specificity 92%) makes it possible to differentiate these two groups of patients.
authors.forename: Ye V
authors.initials: YV
authors.lastname: Vasiliyeva
authors.forename: S V
authors.initials: SV
authors.lastname: Lapin
authors.forename: T V
authors.initials: TV
authors.lastname: Blinova
authors.forename: I Yu
authors.initials: IY
authors.lastname: Nikitina
authors.forename: I V
authors.initials: IV
authors.lastname: Liyadova
authors.forename: V N
authors.initials: VN
authors.lastname: Verbov
authors.forename: A A
authors.initials: AA
authors.lastname: Totolyan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D055985:Latent Tuberculosis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D019798:Neopterin / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D011933:Reagent Kits, Diagnostic; D019798:Neopterin; D007371:Interferon-gamma