title: Electrochemical sensor for sensitive detection of paracetamol based on novel multi-walled carbon nanotubes-derived organic-inorganic material.
abstract: A new electrochemical sensor based on a novel organic-inorganic material (PNFCTs) was proposed for detection of paracetamol in this paper. First, PNFCTs were prepared with multi-walled carbon nanotubes (MWNTs) and a derivative of 3,4,9,10-perylenetetracarboxylic dianhydride (PTC-NH2) via cross-linking method. Then, PNFCTs were coated onto the surface of the glassy carbon electrode (GCE) to form porous organic conducting polymer films (PNFCTs/GCE), which could not only increase the loading of paracetamol efficiently but also provide an interface with exceptional electrical conductivity for paracetamol. Finally, gold nanoparticles (GNPs) were attached to the electrode surface through electrodepositing method, which obtained GNPs/PNFCTs/GCE electrode. The electrochemical behavior of paracetamol on GNPs/PNFCTs/GCE was explored by cyclic voltammetrys (CVs) and differential pulse voltammograms (DPVs). The results showed that the GNPs/PNFCTs/GCE exhibited excellent electrocatalytic activity to paracetamol, which should be attributed to remarkable properties of the new composite nanomaterials with porous nanostructure and exceptional electrical conductivity. The wide liner range and detection limit were 0.3-575 and 0.1 μM, respectively. Finally, it was successfully used to detect paracetamol in dilution human serum and commercial tablets. The sensor shows great promise for simple, sensitive, and selective detection paracetamol and provides a promising approach in paracetamol clinical research and overdose diagnostic applications.
authors.affiliation: Institute of Life Science, Chongqing Medical University, Chongqing, 400016, People's Republic of China, hjmgood@163.com.
authors.forename: Junmin
authors.initials: J
authors.lastname: Hui
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yang
authors.forename: Yingxiong
authors.initials: Y
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Yu
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D007287:Inorganic Chemicals / Q000737:chemistry*; D057230:Limit of Detection; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon; D009930:Organic Chemicals / Q000737:chemistry*
chemical_list: D007287:Inorganic Chemicals; D037742:Nanotubes, Carbon; D009930:Organic Chemicals; D000082:Acetaminophen