title: Inserting ex vivo fluorescence confocal microscopy perioperatively in Mohs micrographic surgery expedites bedside assessment of excision margins in recurrent basal cell carcinoma.
abstract: Mohs micrographic surgery can be employed in recurrent basal cell carcinoma, although it is a time-consuming technique. Recently, ex vivo fluorescence confocal microscopy (FCM) has been employed to obtain a fast assessment of tumor margins at the bedside. In our case we successfully employed ex vivo FCM to assess the tumor margins and we treated the persistent tumor with intensity-modulated radiation therapy. Our case demonstrates that a multidisciplinary approach is very efficient in managing complex and recurrent tumors and highlights the benefits of FCM as a new technique that can be used in the surgical theater to speed up the entire procedure.
authors.affiliation: Skin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
authors.forename: Moira
authors.initials: M
authors.lastname: Ragazzi
authors.forename: Fabio
authors.initials: F
authors.lastname: Castagnetti
authors.forename: Stefano
authors.initials: S
authors.lastname: Gardini
authors.forename: Tamara
authors.initials: T
authors.lastname: Palmieri
authors.forename: Aimilios
authors.initials: A
authors.lastname: Lallas
authors.forename: Elvira
authors.initials: E
authors.lastname: Moscarella
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piana
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pellacani
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
mesh_terms: D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D005453:Fluorescence; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D015580:Mohs Surgery / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D018365:Neoplasm, Residual; D019095:Point-of-Care Systems; D050397:Radiotherapy, Intensity-Modulated; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*