title: Risk of differentiated thyroid carcinoma and polymorphisms within the susceptibility cancer region 8q24.
abstract: BACKGROUND
  Genome-wide association studies have shown that the 8q24 region harbours multiple independent cancer susceptibility loci and it was also defined as the "susceptibility cancer region." Thus, it could be hypothesized that genetic variants within this region could play a role in the risk of differentiated thyroid carcinoma (DTC).
  
  
  METHODS
  Six single-nucleotide polymorphisms within 8q24 were analyzed, previously associated with the risk of cancer (i.e., rs6983267, rs1447295, rs10808556, rs7000448, rs13254738, and rs13281615) in a population of 1,250 patients affected by DTC and 1,250 controls from Central and Southern Italy.
  
  
  RESULTS
  A strong association between smoking habit and risk of DTC was found [OR, 1.63; 95% confidence interval (CI), 1.39-1.91; P < 10(-6)]. The polymorphisms rs10808556 and rs1447295 showed an association with the risk of DTC (the strongest were the heterozygotes with OR, 1.38; 95% CI, 1.13-1.68 and OR, 1.35; 95% CI, 1.02-1.78, respectively), but, overall, they were unable to reach the statistically significant threshold following Bonferroni's correction.
  
  
  CONCLUSIONS
  Present study suggested a limited involvement of polymorphisms within 8q24 region in relation to the risk of DTC in Central and Southern Italians.
  
  
  CONCLUSIONS
  The exclusion of a relationship between DTC and 8q24 among Italians further highlights the tissue-specificity of this chromosomal segment in relation to human cancer and stresses the importance of other population-specific cofactors.
authors.affiliation: Authors' Affiliations: Department of Biology, University of Pisa, Pisa; Center for Integrated Biology, University of Trento, Trento; Department of Endocrinology and Metabolism, Orthopaedics and Traumatology, Occupational Medicine, University of Pisa, Pisa; and Operative Unit of Laboratory of Clinical Chemistry Analyses, University Hospital of Cisanello, Pisa, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Cipollini
authors.forename: Gisella
authors.initials: G
authors.lastname: Figlioli
authors.forename: Sonia
authors.initials: S
authors.lastname: Garritano
authors.forename: Simona
authors.initials: S
authors.lastname: Bramante
authors.forename: Loredana
authors.initials: L
authors.lastname: Maiorano
authors.forename: Federica
authors.initials: F
authors.lastname: Gnudi
authors.forename: Alice
authors.initials: A
authors.lastname: Cecchini
authors.forename: Francesca
authors.initials: F
authors.lastname: De Paola
authors.forename: Lucia
authors.initials: L
authors.lastname: Damicis
authors.forename: Tania
authors.initials: T
authors.lastname: Frixa
authors.forename: Debora
authors.initials: D
authors.lastname: Landi
authors.forename: Lisa
authors.initials: L
authors.lastname: Cancemi
authors.forename: Chiara
authors.initials: C
authors.lastname: De Santi
authors.forename: Ombretta
authors.initials: O
authors.lastname: Melaiu
authors.forename: Rudy
authors.initials: R
authors.lastname: Foddis
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cristaudo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bonotti
authors.forename: Cristina
authors.initials: C
authors.lastname: Romei
authors.forename: Rossella
authors.initials: R
authors.lastname: Elisei
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pellegrini
authors.forename: Roberto
authors.initials: R
authors.lastname: Barale
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
mesh_terms: D016022:Case-Control Studies; D002454:Cell Differentiation / Q000235:genetics; D002898:Chromosomes, Human, Pair 8; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology