title: Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication.
abstract: In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.
authors.affiliation: Department of Developmental Genetics, Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Gu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Chi
authors.forename: Dongju
authors.initials: D
authors.lastname: Feng
authors.forename: Fangyi
authors.initials: F
authors.lastname: Xie
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Changyan
authors.initials: C
authors.lastname: Ma
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
mesh_terms: D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000032:analysis; D002460:Cell Line; D015654:Herpesvirus 6, Human / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D013601:T-Lymphocytes / Q000502:physiology* / Q000821:virology*; D014779:Virus Replication
chemical_list: D018797:Cell Cycle Proteins