title: Legg-Calve-Perthes disease in two generations of male family members: a case report.
abstract: Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs in any family member, we recommend genetic analysis and counselling as well as early radiological screening of related children.
authors.affiliation: Department of Orthopaedic Surgery, College of Medicine, University of Dammam, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.
authors.forename: Ammar K
authors.initials: AK
authors.lastname: Al-Omran
authors.forename: Mir
authors.initials: M
authors.lastname: Sadat-Ali
mesh_terms: D000328:Adult; D002648:Child; D024043:Collagen Type II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D011859:Radiography
chemical_list: C499177:COL2A1 protein, human; D024043:Collagen Type II
keywords: Legg-Calve-Perthes
  disease; femur head necrosis; mutations