title: Blood lactate in HIV-infected children on antiretroviral therapy in rural South Africa.
abstract: We studied blood lactate levels in 253 South African children on antiretroviral therapy. The prevalence of hyperlactatemia was 68% and severity was mild in most cases (69%). There was no association of symptoms and/or signs with hyperlactatemia. Independent predictors were lipo-dystrophy, time on antiretroviral therapy and baseline CD4 count. Increased awareness of hyperlactatemia in African children on antiretroviral therapy is warranted.
authors.affiliation: From the *Anova Health Institute, Johannesburg and Tzaneen, South Africa; †Department of Internal Medicine, University of Cape Town; and ‡School of Public Health, University of Cape Town, Cape Town, South Africa.
authors.forename: Mette S
authors.initials: MS
authors.lastname: van Ramshorst
authors.forename: Helen E
authors.initials: HE
authors.lastname: Struthers
authors.forename: James A
authors.initials: JA
authors.lastname: McIntyre
authors.forename: Remco P H
authors.initials: RP
authors.lastname: Peters
mesh_terms: D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D065906:Hyperlactatemia / Q000097:blood* / Q000453:epidemiology / Q000821:virology*; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population; D013019:South Africa / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents; D019344:Lactic Acid