title: Multi-functional fluorescent probe for Hg2+, Cu2+ and ClO- based on a pyrimidin-4-yl phenothiazine derivative.
abstract: A multi-functional fluorescent probe based on PzDPM (10-ethyl-3,7-di(pyrimidin-4-yl)-10H-phenothiazine) for Hg(2+), Cu(2+) and ClO(-) has been synthesized and characterized. The probe comprises an electron-donating fluorophore core of 10-ethylphenothiazine and two Hg(2+)-specific chelating arms of pyrimidin-4-yl. The 10-ethylphenothiazine also acts as a Cu(2+)/ClO(-)-specific reactive moiety. PzDPM exhibits green fluorescence and selectively senses Hg(2+)/Cu(2+) upon coordination/reaction in acetonitrile (MeCN), and behaves as a turn-off chemosensor or ratiometric chemodosimeter, respectively. On the other hand, PzDPM is very weakly emissive in aqueous solution but acts as an excellent turn-on chemodosimeter for ClO(-) in 1 : 4 (v/v) MeCN : Tris-HCl (10 mM, pH = 7.0) with a maximum fluorescent intensity increase of over 110-fold. The probe PzDPM allows the determination of Hg(2+), Cu(2+) and ClO(-) at 10(-7) M levels with satisfactory selectivity.
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China. iamqbmei@njupt.edu.cn iamwhuang@njupt.edu.cn iamdirector@fudan.edu.cn.
authors.forename: Jiena
authors.initials: J
authors.lastname: Weng
authors.forename: Qunbo
authors.initials: Q
authors.lastname: Mei
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Bihai
authors.initials: B
authors.lastname: Tong
authors.forename: Quli
authors.initials: Q
authors.lastname: Fan
authors.forename: Qidan
authors.initials: Q
authors.lastname: Ling
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D003300:Copper / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006997:Hypochlorous Acid / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry*; D010640:Phenothiazines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D010640:Phenothiazines; D011743:Pyrimidines; D006997:Hypochlorous Acid; D003300:Copper; D008628:Mercury; C031637:phenothiazine; C030986:pyrimidine