title: Profiling solute carrier transporters in the human blood-brain barrier.
abstract: The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Geier
authors.forename: E C
authors.initials: EC
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Webb
authors.forename: A C
authors.initials: AC
authors.lastname: Papp
authors.forename: S W
authors.initials: SW
authors.lastname: Yee
authors.forename: W
authors.initials: W
authors.lastname: Sadee
authors.forename: K M
authors.initials: KM
authors.lastname: Giacomini
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000098:blood supply*; D002540:Cerebral Cortex / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D016623:Ion Pumps / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D055806:Microvessels / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D016623:Ion Pumps; D026901:Membrane Transport Proteins