title: Synthesis of new nicotinic acid derivatives and their evaluation as analgesic and anti-inflammatory agents.
abstract: A series of 2-substituted phenyl derivatives of nicotinic acid 4a-l were synthesized and evaluated for their analgesic and anti-inflammatory activities. Compounds including 2-bromophenyl substituent, 4a, c, and d, proved to display distinctive analgesic and anti-inflammatory activities in comparison to mefenamic acid as a reference drug. Compound 4c could be identified as the most biologically active member within this study with an interesting dual anti-inflammatory analgesic profile. Effect of the compounds 4a-l on the serum level of certain inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 was also determined.
authors.affiliation: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University.
authors.forename: Nadia Abdalla
authors.initials: NA
authors.lastname: Khalil
authors.forename: Eman Mohamed
authors.initials: EM
authors.lastname: Ahmed
authors.forename: Khaled Omar
authors.initials: KO
authors.lastname: Mohamed
authors.forename: Sawsan Abo-Bakr
authors.initials: SA
authors.lastname: Zaitone
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D009195:Peroxidase / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D009539:Nicotinic Acids; D014409:Tumor Necrosis Factor-alpha; D009195:Peroxidase