title: Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis.
abstract: Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.
authors.affiliation: Department of Pharmacy, University of California Davis Medical Center, Sacramento, California, USA.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Zhu
authors.forename: George R
authors.initials: GR
authors.lastname: Thompson
authors.forename: Christopher
authors.initials: C
authors.lastname: Kreulen
authors.forename: Eric
authors.initials: E
authors.lastname: Giza
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001843:Bone Cements / Q000737:chemistry*; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D001843:Bone Cements; D000666:Amphotericin B