title: The Midwest Exercise Trial for the Prevention of Weight Regain: MET POWeR.
abstract: Weight reduction in overweight and obese individuals results in physiological and behavioral changes that make the prevention of weight regain more difficult than either initial weight loss or the prevention of weight gain. Exercise is recommended for the prevention of weight regain by both governmental agencies and professional organizations. To date, the effectiveness of exercise recommendations for the prevention of weight regain has not been evaluated in a properly designed, adequately powered trial. Therefore, we will conduct a randomized trial to evaluate the effectiveness of 3 levels of exercise on the prevention of weight regain, in initially overweight and obese sedentary men and women. Participants will complete a 3 month weight loss intervention of decreased energy intake (EI) and increased exercise (100 min/week). Participants achieving clinically significant weight loss (≥ 5% of initial weight), will then be randomly assigned to 12 months of verified exercise at 3 levels (150, 225 or 300 min/week). This study will evaluate: 1) the effectiveness of 3 levels of exercise on the prevention of weight regain over 12 months subsequent to clinically significant weight loss (≥ 5%); 2) gender differences in weight regain in response to 3 levels of exercise; and 3) potential compensatory changes in daily physical activity (PA) and EI on weight regain in response to the 3 levels of exercise. The results of this investigation will provide information to develop evidence-based recommendations for the level of exercise associated with the prevention of weight regain.
authors.affiliation: Cardiovascular Research Institute, Division of Internal Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address: aszabo2@ku.edu.
authors.forename: Amanda N
authors.initials: AN
authors.lastname: Szabo
authors.forename: Richard A
authors.initials: RA
authors.lastname: Washburn
authors.forename: Debra K
authors.initials: DK
authors.lastname: Sullivan
authors.forename: Jeffery J
authors.initials: JJ
authors.lastname: Honas
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Mayo
authors.forename: Jeannine
authors.initials: J
authors.lastname: Goetz
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Lee
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Donnelly
mesh_terms: D000328:Adult; D004038:Diet, Reducing / Q000379:methods; D002149:Energy Intake; D015444:Exercise; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain; D061217:Weight Reduction Programs; D055815:Young Adult
keywords: ACSM; Aerobic exercise; American College of Sports Medicine; EBL; EEEx; EI; Energy Balance Laboratory; Energy expenditure; Gender; HR; IOM; Institute of Medicine; NDS-R; Nutrition Data Systems for Research; Obesity; PA; PCP; PMs; RMR; SCT; Weight management; Weight regain; energy expenditure of exercise; energy intake; heart rate; physical activity; pre-packaged meals; primary care provider; resting metabolic rate; social cognitive theory