title: Weight loss-induced reduction in physical activity recovers during weight maintenance.
abstract: BACKGROUND
  Weight loss due to a negative energy balance is considered to be accompanied by a decrease in physical activity.
  
  
  OBJECTIVE
  The aim of this study was to investigate whether a decrease in physical activity is sustained during weight maintenance.
  
  
  METHODS
  Subjects were 20 men and 31 women [mean (±SD) age: 42 ± 8 y; BMI (in kg/m(2)): 31.4 ± 2.8]. Weight loss was achieved by an 8-wk very-low-energy diet period, followed by 44 wk of weight maintenance. Physical activity measures were total energy expenditure expressed as a multiple of sleeping metabolic rate (PALSMR) and resting metabolic rate (PALRMR), activity-induced energy expenditure divided by body weight (AEE/kg), and activity counts measured by a triaxial accelerometer. Measurements took place at 0, 8, and 52 wk.
  
  
  RESULTS
  Body mass decreased significantly during the diet period (10.5 ± 3.8%, P < 0.001), and this reduction was sustained after 52 wk (6.0 ± 5.1%, P < 0.001). PALSMR and PALRMR decreased from 1.81 ± 0.23 and 1.70 ± 0.22, respectively, before the diet to 1.69 ± 0.20 and 1.55 ± 0.19 after the diet (P < 0.001) and increased again after weight maintenance to 1.85 ± 0.27 and 1.71 ± 0.23, respectively, compared with 8-wk measurements (P < 0.001). AEE/kg decreased from 0.043 ± 0.015 MJ/kg at baseline to 0.037 ± 0.014 MJ/kg after the diet (P < 0.001) and was higher after 52 wk (0.044 ± 0.17 MJ/kg) compared with after 8 wk (P < 0.001). Activity counts decreased from 1.64 ± 0.37 megacounts/d at baseline to 1.54 ± 0.35 megacounts/d after the diet (P < 0.05) and were higher after 52 wk (1.73 ± 0.49 megacounts/d) compared with 8 wk (P < 0.01).
  
  
  CONCLUSIONS
  A weight loss-induced reduction in physical activity returns to baseline values when weight loss is maintained. This trial was registered at clinicaltrials.gov as NCT01015508.
authors.affiliation: Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands.
authors.forename: Stefan Gja
authors.initials: SG
authors.lastname: Camps
authors.forename: Sanne Pm
authors.initials: SP
authors.lastname: Verhoef
authors.forename: Klaas R
authors.initials: KR
authors.lastname: Westerterp
mesh_terms: D000328:Adult; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D031204:Caloric Restriction; D004032:Diet; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*; D012890:Sleep / Q000502:physiology; D022722:Thermogenesis; D015431:Weight Loss / Q000502:physiology*