title: Engineering parameters in bioreactor's design: a critical aspect in tissue engineering.
abstract: Bioreactors are important inevitable part of any tissue engineering (TE) strategy as they aid the construction of three-dimensional functional tissues. Since the ultimate aim of a bioreactor is to create a biological product, the engineering parameters, for example, internal and external mass transfer, fluid velocity, shear stress, electrical current distribution, and so forth, are worth to be thoroughly investigated. The effects of such engineering parameters on biological cultures have been addressed in only a few preceding studies. Furthermore, it would be highly inefficient to determine the optimal engineering parameters by trial and error method. A solution is provided by emerging modeling and computational tools and by analyzing oxygen, carbon dioxide, and nutrient and metabolism waste material transports, which can simulate and predict the experimental results. Discovering the optimal engineering parameters is crucial not only to reduce the cost and time of experiments, but also to enhance efficacy and functionality of the tissue construct. This review intends to provide an inclusive package of the engineering parameters together with their calculation procedure in addition to the modeling techniques in TE bioreactors.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Nasim
authors.initials: N
authors.lastname: Salehi-Nik
authors.forename: Ghassem
authors.initials: G
authors.lastname: Amoabediny
authors.forename: Behdad
authors.initials: B
authors.lastname: Pouran
authors.forename: Hadi
authors.initials: H
authors.lastname: Tabesh
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Shokrgozar
authors.forename: Nooshin
authors.initials: N
authors.lastname: Haghighipour
authors.forename: Nahid
authors.initials: N
authors.lastname: Khatibi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Anisi
authors.forename: Khosrow
authors.initials: K
authors.lastname: Mottaghy
authors.forename: Behrouz
authors.initials: B
authors.lastname: Zandieh-Doulabi
mesh_terms: D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008297:Male; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008954:Models, Biological; D023822:Tissue Engineering / Q000295:instrumentation*