title: [Levels of serum IL-4, IFN-gamma, IL-32 in children with juvenile-onset recurrent respiratory papillomatosis].
abstract: OBJECTIVE
  To explore the relationship between serum IL-4, IFN-gamma, IL-10 levels and the aetiology of juvenile-onset recurrent respiratory papillomatosis.
  
  
  METHODS
  Serum IL-4, IFN-gamma, IL-32 levels of 15 JORRP children were detected by use of enzyme-linked immunosorbent assay (ELISA) and compared with those of healthy control group.
  
  
  RESULTS
  Serum IL-4 levels were significantly higher in the JORRP children (P<0.01): (524.65 +/- 147.77)pg/ml in the JORRP children and (213.27 +/- 87.48) pg/ml in the healthy control group. Serum IFN-gamma levels were significantly lower in the JORRP children (P<0.01): (2.87 +/- 0.84) pg/ml in the JORRP children and (10.63 +/- 5.09) pg/ml in the healthy control group. Serum IL-32 levels were significantly lower in the JORRP children (P< 0.01): (2.47 +/- 1.60) pg/ml in the JORRP children and (9.08 +/- 2.66) pg/ml in the healthy control group.
  
  
  CONCLUSIONS
  1) While the concentration of Th2 like cytokine IL-4 in children with JORRP was higher than that in control group, the concentration of Th1 like cytokine IFN-gamma in children with JORRP was lower than that in controls, indicating that the polarization of Th1 /Th2 T cell in children with JORRP; 2) The polarization of Th1/Th2 T cell may cause the reduction of the serum IL-32 as a proinflammatory role in host immunity system that could not eradicate HPVs because of lacking enough inflammatory stimulation.
authors.affiliation: Department of Otorhinolaryngology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325027, China.
authors.forename: Benyu
authors.initials: B
authors.lastname: Nan
authors.forename: Bobei
authors.initials: B
authors.lastname: Chen
authors.forename: Chuqin
authors.initials: C
authors.lastname: Zhang
authors.forename: Minghua
authors.initials: M
authors.lastname: Jiang
authors.forename: Yuyao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haijie
authors.initials: H
authors.lastname: Xiang
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
mesh_terms: D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D030361:Papillomavirus Infections / Q000097:blood*; D012141:Respiratory Tract Infections / Q000097:blood*
chemical_list: C496971:IL32 protein, human; D007378:Interleukins; D015847:Interleukin-4; D007371:Interferon-gamma