title: The comparison of glycometabolism parameters and lipid profiles between drug-naïve, first-episode schizophrenia patients and healthy controls.
abstract: To compare the difference in body mass index (BMI), waist-to-hip ratio (WHR), and glucose and lipid metabolism parameters between drug-naïve, first-episode schizophrenia patients and healthy controls matched for age, ethnicity and gender, we conducted a test including BMI, WHR, and fasting glucose and lipid metabolism parameters in both 70 drug-naïve, first-episode schizophrenia patients, having not a single day of cumulative exposure to antipsychotic medications and 44 normal healthy controls at baseline. Student's t tests (two tailed) were conducted to examine between group differences. We found that drug-naïve first-episode schizophrenia patients had higher insulin, insulin resistance and C-peptide levels, and had lower total cholesterol (TC), high density lipoprotein cholesterol (HDL-c) and apolipoproteinA1 levels. Simultaneously, drug-naïve, first-episode schizophrenia patients show a potential tendency of WHR enlargement, although there were no statistically significant differences between groups (mean=0.82, SD=0.06, for the patients versus mean=0.79, SD=0.06, for the health subjects). These results suggest that drug-naïve, first-episode schizophrenia patients do differ from healthy controls in their fasting glycometabolism parameters and lipid profiles, including fasting plasma levels of insulin, C-peptide, TC, HDL-c, and apolipoproteinA1, and patients are more insulin resistant before the onset of antipsychotic medication treatment.
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, PR China; Psychiatry Department, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, PR China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.forename: Zeping
authors.initials: Z
authors.lastname: Huang
authors.forename: Renrong
authors.initials: R
authors.lastname: Wu
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhong
authors.forename: Qinling
authors.initials: Q
authors.lastname: Wei
authors.forename: Houliang
authors.initials: H
authors.lastname: Wang
authors.forename: Feici
authors.initials: F
authors.lastname: Diao
authors.forename: Jihui
authors.initials: J
authors.lastname: Wang
authors.forename: Liangrong
authors.initials: L
authors.lastname: Zheng
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.forename: Jinbei
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood; D005215:Fasting; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D019370:Observation; D011446:Prospective Studies; D012559:Schizophrenia / Q000097:blood* / Q000473:pathology; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D001054:Apolipoproteins A; D001786:Blood Glucose; D002096:C-Peptide; D008076:Cholesterol, HDL; D008055:Lipids
keywords: Drug-naïve; First-episode; Glycometabolism parameters; Healthy controls; Lipid profiles; Schizophrenia