title: Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.
abstract: The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. ovidiu@nmr.mgh.harvard.edu
authors.forename: Ovidiu C
authors.initials: OC
authors.lastname: Andronesi
authors.forename: Otto
authors.initials: O
authors.lastname: Rapalino
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gerstner
authors.forename: Andrew
authors.initials: A
authors.lastname: Chi
authors.forename: Tracy T
authors.initials: TT
authors.lastname: Batchelor
authors.forename: Dan P
authors.initials: DP
authors.lastname: Cahill
authors.forename: A Gregory
authors.initials: AG
authors.lastname: Sorensen
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Rosen
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005977:Glutarates / Q000378:metabolism*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009682:Magnetic Resonance Spectroscopy; D009154:Mutation; D059906:Neuroimaging
chemical_list: D014408:Biomarkers, Tumor; D005977:Glutarates; C019417:alpha-hydroxyglutarate; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human