title: Modelling the efficacy of hyperthermia treatment.
abstract: Multimodal oncological strategies which combine chemotherapy or radiotherapy with hyperthermia, have a potential of improving the efficacy of the non-surgical methods of cancer treatment. Hyperthermia engages the heat-shock response (HSR) mechanism, the main component of which are heat-shock proteins. Cancer cells have already partially activated HSR, thereby hyperthermia may be more toxic to them relative to normal cells. On the other hand, HSR triggers thermotolerance, i.e. hyperthermia-treated cells show an impairment in their susceptibility to a subsequent heat-induced stress. This poses questions about efficacy and optimal strategy for anti-cancer therapy combined with hyperthermia treatment. To address these questions, we adapt our previous HSR model and propose its stochastic extension. We formalize the notion of a HSP-induced thermotolerance. Next, we estimate the intensity and the duration of the thermotolerance. Finally, we quantify the effect of a multimodal therapy based on hyperthermia and a cytotoxic effect of bortezomib, a clinically approved proteasome inhibitor. Consequently, we propose an optimal strategy for combining hyperthermia and proteasome inhibition modalities. In summary, by a mathematical analysis of HSR, we are able to support the common belief that the combination of cancer treatment strategies increases therapy efficacy.
authors.affiliation: Institute of Informatics, University of Warsaw, Warsaw, Poland. mikolaj.rybinski@bsse.ethz.ch
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Rybinski
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Szymanska
authors.forename: Sławomir
authors.initials: S
authors.lastname: Lasota
authors.forename: Anna
authors.initials: A
authors.lastname: Gambin
mesh_terms: D003131:Combined Modality Therapy; D018869:Heat-Shock Response; D006801:Humans; D006979:Hyperthermia, Induced; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D061988:Proteasome Inhibitors / Q000627:therapeutic use; D013269:Stochastic Processes
chemical_list: D061988:Proteasome Inhibitors
keywords: computational modelling; heat-shock response; hyperthermia; mass action kinetics; proteasome inhibitor; thermotolerance