title: Effects of mosapride on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.
abstract: BACKGROUND
  The effects of the prokinetic drug mosapride on esophageal motor activity vary at standard doses. In addition to esophageal motor activities, compliance of the esophagogastric junction (EGJ) is important for prevention of gastroesophageal reflux. However, the effects of mosapride on EGJ compliance have not been reported. Here, we investigated the effects of high-dose mosapride on esophageal motor activities and EGJ compliance.
  
  
  METHODS
  Nine healthy volunteers were enrolled in the study. Peristaltic esophageal contraction and lower esophageal sphincter pressures before and after administration of 40 mg mosapride were examined by high resolution esophageal manometry. Esophageal compliance was also investigated by intra-esophageal impedance planimetry (EndoFLIP(®)).
  
  
  RESULTS
  High-dose mosapride augmented peristaltic contractions, especially in the distal esophageal segments (P < 0.05). The mean resting lower esophageal sphincter pressure was elevated from 25.0 mmHg before administration to 28.9 mmHg after (P < 0.05). In addition, mosapride significantly reduced EGJ compliance (P < 0.05).
  
  
  CONCLUSIONS
  Mosapride at 40 mg augmented esophageal motor activities and reduced EGJ compliance in healthy volunteers.
authors.affiliation: Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan, fkousuke@waltz.ocn.ne.jp.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Fukazawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Furuta
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Moritou
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Saito
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.forename: Goichi
authors.initials: G
authors.lastname: Uno
authors.forename: Shino
authors.initials: S
authors.lastname: Shimura
authors.forename: Masahito
authors.initials: M
authors.lastname: Aimi
authors.forename: Shunji
authors.initials: S
authors.lastname: Ohara
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D003187:Compliance / Q000187:drug effects; D049630:Esophageal Sphincter, Lower / Q000187:drug effects / Q000378:metabolism; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000378:metabolism; D004947:Esophagus / Q000187:drug effects* / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects; D011312:Pressure; D055815:Young Adult
chemical_list: D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; C062720:mosapride