title: The Expression of CD10 and CD15 Is Progressively Increased during Colorectal Cancer Development.
abstract: BACKGROUND
  The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC.
  
  
  METHODS
  We performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon.
  
  
  RESULTS
  CD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth.
  
  
  CONCLUSIONS
  The present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.
authors.affiliation: Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
authors.forename: Tae Jung
authors.initials: TJ
authors.lastname: Jang
authors.forename: Jeong Bae
authors.initials: JB
authors.lastname: Park
authors.forename: Jong Im
authors.initials: JI
authors.lastname: Lee
keywords: Antigens, CD15; Colorectal neoplasms; Neprilysin