title: The role of NEFL in cell growth and invasion in head and neck squamous cell carcinoma cell lines.
abstract: The neurofilament light polypeptide (NEFL) gene located on chromosome 8q21 is associated with the cancer of several organs and is regarded as a potential tumor suppressor gene. However, the role of the NEFL protein has not yet been studied in cancer cells. Although evidence suggests that there is a correlation between NEFL expression and cancer, studies regarding the role of the NEFL protein have been mostly limited to neurological diseases, such as Charcot-Marie-Tooth's disease (CMT). Most of these studies have not explored the role of NEFL in cancer cell apoptosis and/or invasion. In this study, NEFL expression was manipulated, and apoptosis and invasion were compared in head and neck squamous cell carcinoma cell lines. The results show that the expression of NEFL induces cancer cell apoptosis and inhibits invasion in these cell lines, suggesting that NEFL may play a role in cancer cell apoptosis and invasion.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Key Laboratory of malignant tumor gene regulation and target therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Huang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Zhuojian
authors.initials: Z
authors.lastname: Shen
authors.forename: Youyuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Haigang
authors.initials: H
authors.lastname: Li
authors.forename: Ju
authors.initials: J
authors.lastname: Chen
authors.forename: Weiliang
authors.initials: W
authors.lastname: Chen
mesh_terms: D017209:Apoptosis / Q000502:physiology; D063646:Carcinogenesis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D053148:Caspase 3 / Q000032:analysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D020868:Gene Silencing; D005822:Genetic Vectors / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D016900:Neurofilament Proteins / Q000235:genetics / Q000502:physiology*; D034741:RNA, Small Interfering; D014162:Transfection
chemical_list: D016900:Neurofilament Proteins; D034741:RNA, Small Interfering; C044882:neurofilament protein L; C505407:CASP3 protein, human; D053148:Caspase 3
keywords: NEFL; growth; head and neck squamous cell carcinoma; invasion