title: Predictive genetic testing of a bone marrow recipient-ethical issues involving unexpected results, gender issues, test accuracy, and implications for the donor.
abstract: We present a case where an apparently straightforward Lynch syndrome predictive genetic test of DNA from a blood sample from a woman yielded an unexpected result of X/Y chromosome imbalance. Furthermore, it demonstrates the complexities of genetic testing in people who have had bone marrow transplants. This highlights the potential for multiple ethical and counselling challenges, including the inadvertent testing of the donor. Good communication between clinics and laboratories is essential to overcome such challenges and to minimise the provision of false results.
authors.affiliation: Familial Cancer Centre, Royal Melbourne Hospital, 2-Centre, Grattan St, Parkville, VIC, 3050, Australia, adrienne.sexton@mh.org.au.
authors.forename: A
authors.initials: A
authors.lastname: Sexton
authors.forename: L
authors.initials: L
authors.lastname: Rawlings
authors.forename: M
authors.initials: M
authors.lastname: Jenkins
authors.forename: I
authors.initials: I
authors.lastname: Winship
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation; D004989:Ethics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014019:Tissue Donors