title: Immunomodulatory drugs: oral and systemic adverse effects.
abstract: OBJECTIVE
  The main objectives are to present the different adverse effects of the immunomodulatory drugs that can impair the quality of life of the immunosuppressed patients and study the impact of immunomodulation on oral diseases. Immunomodulatory drugs have changed the treatment protocols of many diseases where immune functions play a central role, such as rheumatic diseases. Their effect on oral health has not been systematically investigated, however.
  
  
  METHODS
  We review current data on the new immunomodulatory drugs from the oral health perspective based on open literature search of the topic.
  
  
  RESULTS
  These target specific drugs appear to have less drug interactions than earlier immunomodulating medicines but have nevertheless potential side effects such as activating latent infections. There are some data showing that the new immunomodulatory drugs may also have a role in the treatment of certain oral diseases such as lichen planus or ameliorating symptoms in Sjögren's syndrome, but the results have not been overly promising.
  
  
  CONCLUSIONS
  In general, data are sparse of the effect of these new drugs vs. oral diseases and there are no properly powered randomized controlled trials published on this topic.
authors.affiliation: Department of Medicine and Bucofacial Surgery, Dental School, Complutense University of Madrid, Plaza Ramón y Cajal 3, Ciudad Universitaria, 28040-Madrid, Spain, antbasco@arrakis.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bascones-Martinez
authors.forename: Riikka
authors.initials: R
authors.lastname: Mattila
authors.forename: Rafael
authors.initials: R
authors.lastname: Gomez-Font
authors.forename: Jukka H
authors.initials: JH
authors.lastname: Meurman
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D009059:Mouth Diseases / Q000139:chemically induced*
chemical_list: D007155:Immunologic Factors