title: Reduction of epidural fibrosis and dural adhesions after lamina reconstruction by absorbable cement: an experimental study.
abstract: BACKGROUND
  Post-laminectomy epidural fibrosis complicates revision spine surgery and is implicated in cases of "failed back syndrome." Several materials have been used to minimize epidural fibrosis with varying results.
  
  
  OBJECTIVE
  The aim of this study was to examine the impact of reconstruction of laminectomy site with a type of absorbable cement (Jectos) to reduce epidural fibrosis.
  
  
  METHODS
  This investigation is an experimental controlled study, which is designed to evaluate the preventive effects of laminectomy site reconstruction in rat laminectomy model.
  
  
  METHODS
  Twenty wistar rats were included in this study and divided randomly to two equal groups, namely, subject and control. In both groups, laminectomy was performed in L2 and L4 levels. Control group received no additional treatment. In the subject group, L4 levels were reconstructed by Jectos and L2 levels were non-reconstructed as internal controls. Six months after surgery the rats were sacrificed and the dural adhesion and epidural fibrosis were evaluated macroscopically and microscopically. The study was financially supported by Brain and Spinal Cord Injuries Repair Center. None of the authors have any conflict of interest.
  
  
  RESULTS
  Non-reconstructed levels in both groups showed dense epidural fibrosis with marked dural adherence. L4 reconstructed levels in subject group showed reduced epidural fibrosis macroscopically (p=.024) and microscopically (p=.041). No foreign body reaction or ossification occurred at reconstructed sites.
  
  
  CONCLUSIONS
  In the present study, lamina reconstruction with absorbable cement was a safe method that significantly reduced post-laminectomy epidural fibrosis and dural adhesions in rat laminectomy model.
authors.affiliation: Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 1419733141, Iran; Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran. Electronic address: m.zeinalizade@gmail.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zeinalizadeh
authors.affiliation: Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 1419733141, Iran; Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran.
authors.forename: Seyed Mojtaba
authors.initials: SM
authors.lastname: Miri
authors.affiliation: Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 1419733141, Iran.
authors.forename: Farid Azmoodeh
authors.initials: FA
authors.lastname: Ardalan
authors.affiliation: Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Maleki
authors.affiliation: Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Zakeri
authors.affiliation: Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Aghajanzadeh
authors.affiliation: Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran 1419733141, Iran; Brain and Spinal Cord Injuries Repair Research Center, Imam Khomeini Hospital, Tehran 1419733141, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Habibi
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D004824:Epidural Space / Q000473:pathology / Q000601:surgery*; D005355:Fibrosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007796:Laminectomy / Q000009:adverse effects*; D008159:Lumbar Vertebrae; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D001843:Bone Cements
keywords: Dural adhesion; Epidural fibrosis; Lamina reconstruction; Laminectomy; Revision spine surgery