title: Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
abstract: Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.
authors.affiliation: Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kuroki
authors.forename: Shogo
authors.initials: S
authors.lastname: Matoba
authors.forename: Mika
authors.initials: M
authors.lastname: Akiyoshi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyachi
authors.forename: Nathan
authors.initials: N
authors.lastname: Mise
authors.forename: Kuniya
authors.initials: K
authors.lastname: Abe
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ogura
authors.forename: Dagmar
authors.initials: D
authors.lastname: Wilhelm
authors.forename: Peter
authors.initials: P
authors.lastname: Koopman
authors.forename: Masami
authors.initials: M
authors.lastname: Nozaki
authors.forename: Yoshiakira
authors.initials: Y
authors.lastname: Kanai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Shinkai
authors.forename: Makoto
authors.initials: M
authors.lastname: Tachibana
mesh_terms: D000818:Animals; D004822:Epididymis / Q000002:abnormalities; D044127:Epigenesis, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000378:metabolism*; D056484:Jumonji Domain-Containing Histone Demethylases / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008745:Methylation; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D010053:Ovary / Q000002:abnormalities / Q000201:enzymology; D011499:Protein Processing, Post-Translational; D019849:Sex Determination Processes / Q000235:genetics*; D013737:Testis / Q000002:abnormalities / Q000201:enzymology; D014599:Uterus / Q000002:abnormalities
chemical_list: D006657:Histones; D056484:Jumonji Domain-Containing Histone Demethylases; C511045:Kdm3a protein, mouse