title: Partially reversible cardiomyopathy after renal transplant associated with anti-troponin I antibodies.
abstract: Cardiomyopathy associated with dialysis has been shown to be reversible in some cases. A 58-year-old female patient with polycystic renal disease and end-stage renal disease had a renal transplant after 9 years on hemodialysis. Dilated cardiomyopathy with depressed left ventricular ejection fraction markedly improved after transplantation, with normalization of the ejection fraction. High titers for anti-troponin I antibodies were measured: IgG 1:640, IgM 1:80. In our case, the presence of anticardiac (anti-troponin I) antibodies may suggest that the syndrome of reversible cardiomyopathy seen after renal transplantation is associated with immunosuppression therapy acting on immunological mechanisms previously at play.
authors.affiliation: Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
authors.forename: José Pedro L
authors.initials: JP
authors.lastname: Nunes
authors.forename: Maria
authors.initials: M
authors.lastname: do Sameiro Faria
authors.forename: Susana
authors.initials: S
authors.lastname: Sampaio
authors.forename: José
authors.initials: J
authors.lastname: Quintas
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Katus
authors.forename: Ziya
authors.initials: Z
authors.lastname: Kaya
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000601:surgery; D006435:Renal Dialysis / Q000009:adverse effects; D019210:Troponin I / Q000276:immunology*
chemical_list: D000906:Antibodies; D007166:Immunosuppressive Agents; D019210:Troponin I