title: Cholesterol metabolism and Rett syndrome pathogenesis.
abstract: Rett syndrome is caused by mutations in the gene encoding the transcriptional regulator MECP2. A new study demonstrates that cholesterol homeostasis is disrupted in Mecp2 mutant mice and suggests new therapeutic options for this disease.
authors.forename: Gabor
authors.initials: G
authors.lastname: Nagy
authors.forename: Susan L
authors.initials: SL
authors.lastname: Ackerman
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D008297:Male; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics*; D009154:Mutation; D015518:Rett Syndrome / Q000235:genetics* / Q000378:metabolism*
chemical_list: D051783:Methyl-CpG-Binding Protein 2; D002784:Cholesterol