title: Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes.
abstract: Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.
authors.affiliation: Department of Virology, University of Tampere, Tampere, Finland.
authors.forename: Sami
authors.initials: S
authors.lastname: Oikarinen
authors.forename: Sisko
authors.initials: S
authors.lastname: Tauriainen
authors.forename: Didier
authors.initials: D
authors.lastname: Hober
authors.forename: Bernadette
authors.initials: B
authors.lastname: Lucas
authors.forename: Andriani
authors.initials: A
authors.lastname: Vazeou
authors.forename: Amirbabak
authors.initials: A
authors.lastname: Sioofy-Khojine
authors.forename: Evangelos
authors.initials: E
authors.lastname: Bozas
authors.forename: Peter
authors.initials: P
authors.lastname: Muir
authors.forename: Hanna
authors.initials: H
authors.lastname: Honkanen
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
authors.forename: Mikael
authors.initials: M
authors.lastname: Knip
authors.forename: Päivi
authors.initials: P
authors.lastname: Keskinen
authors.forename: Marja-Terttu
authors.initials: MT
authors.lastname: Saha
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Glyn
authors.initials: G
authors.lastname: Stanway
authors.forename: Christos
authors.initials: C
authors.lastname: Bartsocas
authors.forename: Johnny
authors.initials: J
authors.lastname: Ludvigsson
authors.forename: Keith
authors.initials: K
authors.lastname: Taylor
authors.forename: Heikki
authors.initials: H
authors.lastname: Hyöty
mesh_terms: D000293:Adolescent; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology* / Q000821:virology*; D029822:Enterovirus B, Human / Q000502:physiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D006683:HLA-DQ Antigens