title: Novel porphyrin-psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies.
abstract: A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).
authors.affiliation: Department of Chemistry, Birla Institute of Technology & Science, Pilani-333 031, India. dalipk@pilani.bits-pilani.ac.in.
authors.forename: Dalip
authors.initials: D
authors.lastname: Kumar
authors.forename: Bhupendra A
authors.initials: BA
authors.lastname: Mishra
authors.forename: K P
authors.initials: KP
authors.lastname: Chandra Shekar
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Kanako
authors.initials: K
authors.lastname: Akamatsu
authors.forename: Ryohsuke
authors.initials: R
authors.lastname: Kurihara
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D005363:Ficusin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005453:Fluorescence; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D003300:Copper; D004247:DNA; D005363:Ficusin