title: Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom.
abstract: To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40℃ for 24 h.
authors.affiliation: Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea.
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Seo
authors.forename: Eun-Na
authors.initials: EN
authors.lastname: Lee
authors.forename: Geon-Sik
authors.initials: GS
authors.lastname: Seo
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
keywords: Antidementia; BACE1; Lentinula edodes; β-Secretase inhibitor