title: Gut microbiota from twins discordant for obesity modulate metabolism in mice.
abstract: The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their corresponding fecal bacterial culture collections. Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cage mates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota and was diet-dependent. These findings reveal transmissible, rapid, and modifiable effects of diet-by-microbiota interactions.
authors.affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
authors.forename: Vanessa K
authors.initials: VK
authors.lastname: Ridaura
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Faith
authors.forename: Federico E
authors.initials: FE
authors.lastname: Rey
authors.forename: Jiye
authors.initials: J
authors.lastname: Cheng
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Duncan
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Kau
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Griffin
authors.forename: Vincent
authors.initials: V
authors.lastname: Lombard
authors.forename: Bernard
authors.initials: B
authors.lastname: Henrissat
authors.forename: James R
authors.initials: JR
authors.lastname: Bain
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Muehlbauer
authors.forename: Olga
authors.initials: O
authors.lastname: Ilkayeva
authors.forename: Clay F
authors.initials: CF
authors.lastname: Semenkovich
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Funai
authors.forename: David K
authors.initials: DK
authors.lastname: Hayashi
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Lyle
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Martini
authors.forename: Luke K
authors.initials: LK
authors.lastname: Ursell
authors.forename: Jose C
authors.initials: JC
authors.lastname: Clemente
authors.forename: William
authors.initials: W
authors.lastname: Van Treuren
authors.forename: William A
authors.initials: WA
authors.lastname: Walters
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Newgard
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Gordon
mesh_terms: D050154:Adiposity; D000328:Adult; D000818:Animals; D041963:Bacteroidetes / Q000235:genetics / Q000502:physiology*; D002432:Cecum / Q000378:metabolism / Q000382:microbiology; D018752:Diet, Fat-Restricted; D005243:Feces / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D005856:Germ-Free Life; D006801:Humans; D055442:Metabolome; D054892:Metagenome / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D013851:Thinness / Q000382:microbiology; D014427:Twins; D015430:Weight Gain; D055815:Young Adult