title: Relative bioavailability of tropical volcanic soil-bound chlordecone in piglets.
abstract: The application of chlordecone (CLD), a chlorinated polycyclic ketone pesticide, until 1993 in the French West Indies has resulted in long-term pollution of agricultural soils (10% of them exceed 1 mg kg(-1)). The aim of this study was to assess the impact of two tropical volcanic soils, an andosol and a nitisol, on CLD availability in piglets, using the relative bioavailability (RBA) approach. For both soils and relative to an oil matrix, RBA was close to 100%, indicating that CLD was not retained in the soil matrices during the piglet digestive process. Additionally, after a 14 day exposure period, liver and subcutaneous fat CLD concentrations exceeded the maximum residue limit (10 μg kg(-1) of fresh matter and 100 μg kg(-1) of fat for liver and subcutaneous fat, respectively) beyond a CLD ingestion of 2.1 and 6.8 μg CLD kg(-1) of body weight per day, respectively. Thus, rearing practices in CLD-contaminated areas should avoid involuntary soil ingestion by farm animals.
authors.affiliation: Université de Lorraine, UR Animal et Fonctionnalités des Produits Animaux, EA 3998, USC INRA 340, ENSAIA, 2 avenue de la Forêt de Haye TSA 40402, F-54518 Vandoeuvre-lès-Nancy Cedex, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Bouveret
authors.forename: Guido
authors.initials: G
authors.lastname: Rychen
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lerch
authors.forename: Catherine
authors.initials: C
authors.lastname: Jondreville
authors.forename: Cyril
authors.initials: C
authors.lastname: Feidt
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D007631:Chlordecone / Q000737:chemistry / Q000378:metabolism*; D007306:Insecticides / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D012989:Soil Pollutants / Q000737:chemistry / Q000378:metabolism*; D050151:Subcutaneous Fat / Q000737:chemistry / Q000378:metabolism; D013552:Swine / Q000378:metabolism*; D018707:Volcanic Eruptions / Q000032:analysis
chemical_list: D007306:Insecticides; D012989:Soil Pollutants; D007631:Chlordecone