title: Calcarides A-E, antibacterial macrocyclic and linear polyesters from a Calcarisporium strain.
abstract: Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (1-5), and five new derivatives thereof, named calcarides A-E (6-10). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
authors.affiliation: Kiel Center for Marine Natural Products KiWiZ, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, Kiel 24106, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Silber
authors.forename: Birgit
authors.initials: B
authors.lastname: Ohlendorf
authors.forename: Antje
authors.initials: A
authors.lastname: Labes
authors.forename: Arlette
authors.initials: A
authors.lastname: Erhard
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011091:Polyesters