title: Corpus callosotomy is a valuable therapeutic option for patients with Lennox-Gastaut syndrome and medically refractory seizures.
abstract: OBJECTIVE
  We present our experience with corpus callosotomy (CC) in a developing country with limited resources in patients with Lennox-Gastaut syndrome (LGS) and medically refractory seizures.
  
  
  METHODS
  All patients with LGS who underwent CC for medically refractory epilepsy at Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran from May 2009 through March 2012 were reviewed in a retrospective study. Presurgical evaluation included clinical history, neurological examination, a 2-hour video-EEG recording, and 1.5-T MRI. Outcome was evaluated at 6, 12, and 24 months postoperatively. We considered the outcome as a success if the patients were either seizure-free or had more than 85% reduction in seizure frequency compared to their preoperative status.
  
  
  RESULTS
  Eighteen patients (14 males and 4 females) had surgery. Overall, seizures in 11 patients (61.1%) responded favorably one year after surgery; this figure was 6 out of 9 patients (66.6%) two years after surgery. Seven patients (38.8%) were free of disabling seizures one year after CC; this figure was three out of nine patients (33.3%) two years after CC. Three patients (16.6%) were free of all seizure types one year after surgery. Ten patients (55.5%) had no postoperative complications of any kind.
  
  
  CONCLUSIONS
  Corpus callosotomy is an effective palliative surgical procedure for patients with LGS with intractable seizures whose seizures are not amenable to focal resection. This is a feasible treatment option for patients, even for those in developing countries with limited resources.
authors.affiliation: Department of Neurology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address: aliasadipooya@yahoo.com.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Asadi-Pooya
authors.forename: Zahed
authors.initials: Z
authors.lastname: Malekmohamadi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kamgarpour
authors.forename: Seyed Mohamad
authors.initials: SM
authors.lastname: Rakei
authors.forename: Mousa
authors.initials: M
authors.lastname: Taghipour
authors.forename: Nahid
authors.initials: N
authors.lastname: Ashjazadeh
authors.forename: Soroor
authors.initials: S
authors.lastname: Inaloo
authors.forename: Ali
authors.initials: A
authors.lastname: Razmkon
authors.forename: Zahra
authors.initials: Z
authors.lastname: Zare
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000502:physiology / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000601:surgery*; D065768:Lennox Gastaut Syndrome; D008297:Male; D011612:Psychosurgery / Q000379:methods*; D012640:Seizures / Q000601:surgery*; D013036:Spasms, Infantile / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Corpus callosotomy; Lennox–Gastaut syndrome; Outcome; Refractory epilepsy