title: Ablation of atrial fibrillation in Brugada syndrome patients with an implantable cardioverter defibrillator to prevent inappropriate shocks resulting from rapid atrial fibrillation.
abstract: BACKGROUND
  Inappropriate shocks resulting from atrial tachyarrhythmias are highly problematic for patients with an implantable cardioverter defibrillator (ICD). We aimed to determine the effectiveness of catheter ablation of atrial fibrillation (AF) in preventing inappropriate shocks due to rapid AF in patients diagnosed with Brugada syndrome (BS) who were implanted with an ICD.
  
  
  METHODS
  We performed AF ablation in 5 BS patients with ICDs who experienced inappropriate shocks caused by rapid paroxysmal AF and in a BS patient scheduled to determine an indication of an ICD implantation who frequently experienced rapid AF.
  
  
  RESULTS
  Although 2 patients underwent a 2nd ablation procedure because of AF recurrences, 5 of the 6 patients were finally free from AF after their last procedure during a median follow-up period of 43.2 months. No further inappropriate shocks caused by rapid AF occurred after the 1st ablation session in any of the patients. A patient developed a ventricular fibrillation storm during his electrophysiological study following the ablation procedure, and then was implanted with an ICD.
  
  
  CONCLUSIONS
  AF ablation in BS patients may be reasonable to prevent inappropriate ICD shocks resulting from rapid AF. However, ventricular extrastimuli just after the ablation had better be avoided in them.
authors.affiliation: Department of Cardiology, Nagoya Daini Red Cross Hospital, Nagoya, Japan; Department of Cardiology, Graduate School of Medicine, Hiroshima University, Hiroshima, Japan. Electronic address: rjrgw059@ybb.ne.jp.
authors.forename: Akinori
authors.initials: A
authors.lastname: Sairaku
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakano
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000601:surgery*; D053840:Brugada Syndrome / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy*; D017115:Catheter Ablation / Q000379:methods*; D003131:Combined Modality Therapy; D017147:Defibrillators, Implantable / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000628:therapy*
keywords: Ablation; Atrial fibrillation; Brugada syndrome; Implantable cardioverter defibrillator; Inappropriate shock; Ventricular fibrillation