title: Acute and chronic toxic effects of chloramphenicol on Scenedesmus obliquus and Chlorella pyrenoidosa.
abstract: The acute and chronic toxicological effects of Chloramphenicol (CAP) on Scenedesmus obliquus and Chlorella pyrenoidosa are not well understood. The indoor experiments were carried to observe and analyze the CAP induced changes. Results of the observations have showed that CAP exposure could significantly inhibit the growth of Scenedesmus obliquus in almost all the treated groups, while Chlorella pyrenoidosa exhibited less sensitivity. Chlorophyll-a syntheses of Scenedesmus obliquus were all inhibited by CAP exposure, while Chlorella pyrenoidosa displayed obvious stimulation effect. Catalase (CAT) and Superoxide dismutase (SOD) activities of both algae were promoted in all the treatments. The experimental results indicated that the growth and Chlorophyll-a syntheses of Scenedesmus obliquus were more sensitive in response to CAP exposure than that of Chlorella pyrenoidosa. While for CAT and SOD activities, Chlorella pyrenoidosa showed more susceptible. This research provides a basic understanding of CAP toxicity to aquatic organisms.
authors.affiliation: State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai 200237, PR China. wzhang@ecust.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Wenfang
authors.initials: W
authors.lastname: Sun
authors.forename: Shuai
authors.initials: S
authors.lastname: An
authors.forename: Bang
authors.initials: B
authors.lastname: Xiong
authors.forename: Kuangfei
authors.initials: K
authors.lastname: Lin
authors.forename: Xinhong
authors.initials: X
authors.lastname: Cui
authors.forename: Meijin
authors.initials: M
authors.lastname: Guo
mesh_terms: D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D002701:Chloramphenicol / Q000633:toxicity*; D002708:Chlorella / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D002734:Chlorophyll / Q000378:metabolism; D000077194:Chlorophyll A; D017382:Reactive Oxygen Species / Q000378:metabolism; D044444:Scenedesmus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D013482:Superoxide Dismutase / Q000378:metabolism; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic
chemical_list: D000900:Anti-Bacterial Agents; D017382:Reactive Oxygen Species; D002734:Chlorophyll; D002701:Chloramphenicol; D002374:Catalase; D013482:Superoxide Dismutase; D000077194:Chlorophyll A