title: A general strategy for dual-triggered combined tumor therapy based on template semi-graphitized mesoporous silica nanoparticles.
abstract: A general strategy is developed for dual-triggered chemo-photothermal tumor therapy based on template semi-graphitized mesoporous silica nanoparticles (TsGMSN). The strategy endues classic MSN with new charming properties, while easily escaping from toxicity of the surfactant. The doxorubicin-loaded system (TsGMSND) exhibits synergistic heat-stimulative, pH-responsive, and sustained release, and effective combined tumor therapy.
authors.affiliation: Center of Analysis and Measurement, Fudan University, Shanghai, 200433, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Kaiyuan
authors.initials: K
authors.lastname: Wang
authors.forename: Xueying
authors.initials: X
authors.lastname: Yan
authors.forename: Rongqin
authors.initials: R
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D006108:Graphite / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012822:Silicon Dioxide; D006108:Graphite; D004317:Doxorubicin
keywords: chemo-photothermal therapy; graphitization; mesoporous silica; targeted delivery; template