title: The code structure of the p53 DNA-binding domain and the prognosis of breast cancer patients.
abstract: BACKGROUND
  The tumor-suppressor gene TP53 mutations are diverse in the central region encoding the DNA-binding domain. It has not been clear whether the prognostic significance for survival in breast cancer patients is the same for all types of mutations. Are there specific types of mutations carrying a worse prognosis? To understand the correlation between the mutations in the gene encoding the DNA-binding domain and the prognosis of breast cancer, we studied the code structure of the DNA-binding domain of breast cancer patients by using various artificial codes in information transmission.
  
  
  RESULTS
  We indicated that the prognostic significance of all types of mutations in the DNA-binding domain is not the same, and that the DNA-binding domain having a certain code structure is important for estimating the prognosis of breast cancer patients.
  
  
  BACKGROUND
  keiko@is.noda.tus.ac.jp or hara@is.noda.tus.ac.jp.
authors.affiliation: Department of Information Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Sato
authors.forename: Toshihide
authors.initials: T
authors.lastname: Hara
authors.forename: Masanori
authors.initials: M
authors.lastname: Ohya
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality*; D005260:Female; D016158:Genes, p53; D006801:Humans; D053208:Kaplan-Meier Estimate; D009154:Mutation; D011379:Prognosis; D017434:Protein Structure, Tertiary / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53