title: [Meta analysis of the relationship between human papilloma virus and nasal inverted papilloma].
abstract: OBJECTIVE
  To evaluate the relationship between human papilloma virus (HPV) infection and the occurrence, recurrence and malignant transformation of nasal inverted papilloma (NIP).
  
  
  METHODS
  With comprehensive retrieval of related literature that had been published in databases included Pubmed (1990--2011), Cochrane Library, CNKI (1979-2011), VIP (1989-2011), CBM (1990-2011) and WANFANG Meta-analysis software Rev-Man 5.0 was used to analyze the raw data and to calculate the value of combined odd ratio (OR) and 95% confidence interval (CI).
  
  
  RESULTS
  According to Meta-analysis, the occurrence group between HPV and NIP, the OR was 34.44 and 95% CI was 12.96-91.56; the recurrence group, the OR was 3.66 and 95% CI was 1.77-7.56, to the high-risk HPV, the OR was 1.94 and 95% CI was 0.30-12.58; the malignant transformation group, the OR was 1.79 and 95% CI was 0.94-3.40 to the high-risk HPV, the OR was 49.35 and 95% (CI was 0.45-11.23.
  
  
  CONCLUSIONS
  HPV may play an important role in the occurrence and recurrence of NIP and high-risk HPV was closely related to the progress of NIP.
authors.affiliation: Department of Otolaryngology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Xiao
authors.forename: Shanfeng
authors.initials: S
authors.lastname: Liu
authors.forename: Liyin
authors.initials: L
authors.lastname: Wang
authors.forename: Huimin
authors.initials: H
authors.lastname: Li
authors.forename: Wenwei
authors.initials: W
authors.lastname: Wu
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Wang
mesh_terms: D004279:DNA, Viral; D006801:Humans; D009669:Nose Neoplasms / Q000821:virology*; D018308:Papilloma, Inverted / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology*
chemical_list: D004279:DNA, Viral