title: [Effective treatment with tranexamic acid for chronic disseminated intravascular coagulation associated with aortic dissection].
abstract: An 82-year-old female with a history of aortic dissection was admitted to our hospital for evaluation of thrombocytopenia and a bleeding tendency. Blood coagulation test data demonstrated that the patient had disseminated intravascular coagulation (DIC) secondary to aortic dissection. We initiated anti-fibrinolytic therapy with tranexamic acid. After this anti-fibrinolytic therapy, thrombocytopenia and the levels of fibrinogen and fibrinogen degradation products improved. In addition, we reviewed 7 other patients who were treated with tranexamic acid for DIC associated with aortic dissection. Anti-fibrinolytic therapy with tranexamic acid is effective for treating DIC secondary to aortic dissection.
authors.affiliation: Division of Hematology and Oncology, Kumamoto City Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Keiko
authors.initials: K
authors.lastname: Morikawa
authors.forename: Taichi
authors.initials: T
authors.lastname: Hirano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000150:complications*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid