title: Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging.
abstract: A FRET-based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real-time monitoring of drug release. Moreover, the FRET-based two-photon imaging and drug tracking in deep tissues are also demonstrated.
authors.affiliation: Laboratory of Advanced Materials Department of Chemistry, Fudan University, Shanghai, 200433, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.forename: Biao
authors.initials: B
authors.lastname: Kong
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
authors.forename: Gengfeng
authors.initials: G
authors.lastname: Zheng
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002244:Carbon / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D017785:Photons
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D002244:Carbon; D004317:Doxorubicin
keywords: FRET; carbon nanodots; cytotoxicity; drug delivery; monitoring; two-photon imaging