title: Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients.
abstract: An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqueness given certain clinical observations. A Taylor series expansion method was implemented which found that the model was structurally globally/uniquely identifiable for both on- and off-dialysis phases. The fitted model was then used in a predictive capacity showing that the use of Theralite high cut-off (HCO) or HCO 1100 dialyser gave a significant reduction in myoglobin renal exposure compared to standard haemodialysis (HD).
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address: R.Keir@warwick.ac.uk.
authors.forename: R
authors.initials: R
authors.lastname: Keir
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, United Kingdom.
authors.forename: N D
authors.initials: ND
authors.lastname: Evans
authors.affiliation: Renal Unit, University Hospital Birmingham, B15 2WB, United Kingdom.
authors.forename: C A
authors.initials: CA
authors.lastname: Hutchison
authors.affiliation: Clinica Nefrologica, Università degli Studi di Milano Bicocca, AO San Gerardo Monza, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Vigano
authors.affiliation: Clinica Nefrologica, Università degli Studi di Milano Bicocca, AO San Gerardo Monza, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Stella
authors.affiliation: Clinica Nefrologica, Università degli Studi di Milano Bicocca, AO San Gerardo Monza, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Fabbrini
authors.affiliation: Gambro Dialysatoren GmbH & Co. KG, Hechinegn, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Storr
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, United Kingdom.
authors.forename: M J
authors.initials: MJ
authors.lastname: Chappell
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008962:Models, Theoretical; D009211:Myoglobin / Q000302:isolation & purification*; D006435:Renal Dialysis / Q000379:methods*; D012984:Software
chemical_list: D009211:Myoglobin
keywords: Dialysis; Kinetics; Myoglobin; Parameter estimation; Rhabdomyolysis; Structural identifiability