title: High TMPRSS4 expression is a predictor of poor prognosis in cervical squamous cell carcinoma.
abstract: OBJECTIVE
  The aim of this study was to clarify the clinical role of TMPRSS4 expression in cervical squamous cell carcinoma (CSCC) and to investigate the role of TMPRSS4 in predicting outcomes of patients with CSCC.
  
  
  METHODS
  The retrospective study enrolled 87 patients diagnosed with CSCC between 2004 and 2006. TMPRSS4 expression in CSCC was assessed by immunohistochemistry, and data on clinical variables were collected by retrospective chart review. The impact of TMPRSS4 expression on 5-year disease-free survival (DFS) and 5-year overall survival (OS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modeling.
  
  
  RESULTS
  The high expression of TMPRSS4 was 63.2% in 87 patients with CSCC, and 17.5% in 40 patients with benign cervical disease (P<0.001). High TMPRSS4 expression was significantly associated with tumor grade (P=0.005), lymph node metastasis (P=0.004), and deep cervical stromal invasion (P=0.025). Patients with high expression of TMPRSS4 had shorter OS and DFS than those with low expression (P=0.0205 and P=0.0318, respectively). In multivariate Cox regression analysis, high expression of TMPRSS4 was a potential prognostic indicator for OS (P=0.041) and DFS (P=0.015).
  
  
  CONCLUSIONS
  Our findings suggest that TMPRSS4 might play an important role in the progression of CSCC. TMPRSS4 could be a potential prognostic marker of CSCC.
authors.affiliation: Department of Transfusion, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, PR China. Electronic address: dayecheng_cmu@163.com.
authors.forename: Daye
authors.initials: D
authors.lastname: Cheng
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012697:Serine Endopeptidases / Q000378:metabolism*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D012697:Serine Endopeptidases; C528837:TMPRSS4 protein, human
keywords: Cervical squamous cell carcinoma; Epithelial–mesenchymal transition; Immunohisto chemistry; Prognosis; Type II transmembrane serine proteases