title: Integration of advanced 3D SPECT modeling into the open-source STIR framework.
abstract: OBJECTIVE
  The Software for Tomographic Image Reconstruction (STIR, http://stir.sourceforge.net) package is an open source object-oriented library implemented in C++. Although its modular design is suitable for reconstructing data from several modalities, it currently only supports Positron Emission Tomography (PET) data. In this work, the authors present results for Single Photon Emission Computed Tomography (SPECT) imaging.
  
  
  METHODS
  This was achieved by the complete integration of a 3D SPECT system matrix modeling library into STIR.
  
  
  RESULTS
  The authors demonstrate the flexibility of the combined software by reconstructing simulated and acquired projections from three different scanners with different iterative algorithms of STIR.
  
  
  CONCLUSIONS
  The extension of the open source STIR project with advanced SPECT modeling will enable the research community to study the performance of several algorithms on SPECT data, and potentially implement new algorithms by expanding the existing framework.
authors.affiliation: Department of Physiological Sciences I - Biophysics and Bioengineering Unit, University of Barcelona, Casanova 143, 08036 Barcelona, Spain.
authors.forename: Berta Marti
authors.initials: BM
authors.lastname: Fuster
authors.forename: Carles
authors.initials: C
authors.lastname: Falcon
authors.forename: Charalampos
authors.initials: C
authors.lastname: Tsoumpas
authors.forename: Lefteris
authors.initials: L
authors.lastname: Livieratos
authors.forename: Pablo
authors.initials: P
authors.lastname: Aguiar
authors.forename: Albert
authors.initials: A
authors.lastname: Cot
authors.forename: Domenec
authors.initials: D
authors.lastname: Ros
authors.forename: Kris
authors.initials: K
authors.lastname: Thielemans
mesh_terms: D021621:Imaging, Three-Dimensional / Q000379:methods*; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*