title: Basal and meal-stimulated ghrelin, PYY, CCK levels and satiety in lean women with polycystic ovary syndrome: effect of low-dose oral contraceptive.
abstract: BACKGROUND
  Ghrelin is an orexigenic peptide that stimulates food intake, whereas peptide YY (PYY) and cholecystokinin (CCK) are anorexigenic gut hormones. Patients with polycystic ovary syndrome (PCOS) appear to have alterations in appetite regulation.
  
  
  OBJECTIVE
  We aimed to determine whether fasting or meal-stimulated ghrelin, PYY, CCK, and satiety responses are different between lean PCOS patients and healthy women. We also aimed to assess the potential effect of oral contraceptive use on these hormones and satiety response.
  
  
  METHODS
  We conducted a prospective observational study in a university practice.
  
  
  METHODS
  Eighteen lean PCOS patients and 18 healthy control women matched for age and body mass index underwent measurements of circulating ghrelin, PYY, CCK, and satiety index (SI) before and after a standardized mixed meal at 0, 15, 30, 45, 60, 90, 120, and 180 minutes.
  
  
  METHODS
  For PCOS patients who were treated with ethinyl estradiol 30 μg/drospirenone 3 mg for 3 months, measurements were repeated.
  
  
  RESULTS
  We measured ghrelin, PYY, and CCK levels and SI.
  
  
  RESULTS
  At baseline, fasting ghrelin, PYY, CCK, and SI values in PCOS patients were not different from controls. Meal-stimulated PYY, CCK, and SI were also not different between the groups, whereas PCOS patients had significantly lower meal-stimulated ghrelin levels compared to controls (P = .04). Ghrelin, PYY, CCK, and SI did not show a significant change after treatment with ethinyl estradiol/drospirenone for 3 months.
  
  
  CONCLUSIONS
  Basal and stimulated hunger and satiety hormones in lean PCOS patients are not different from lean healthy women, except for a lower meal-stimulated ghrelin response. Short-term use of a low-dose oral contraceptive does not have an effect on appetite regulation of PCOS.
authors.affiliation: Hacettepe University School of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe, 06100 Ankara, Turkey. yildizbo@yahoo.com.
authors.forename: Gulcan
authors.initials: G
authors.lastname: Arusoglu
authors.forename: Gulden
authors.initials: G
authors.lastname: Koksal
authors.forename: Nese
authors.initials: N
authors.lastname: Cinar
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Duygu Yazgan
authors.initials: DY
authors.lastname: Aksoy
authors.forename: Bulent O
authors.initials: BO
authors.lastname: Yildiz
mesh_terms: D000293:Adolescent; D000328:Adult; D000736:Androstenes / Q000008:administration & dosage; D001481:Basal Metabolism / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002766:Cholecystokinin / Q000097:blood*; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004967:Estrogens / Q000008:administration & dosage; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage; D019894:Peptide YY / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism*; D011446:Prospective Studies; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
chemical_list: D000736:Androstenes; D003276:Contraceptives, Oral; D004967:Estrogens; D054439:Ghrelin; D000451:Mineralocorticoid Receptor Antagonists; D019894:Peptide YY; D004997:Ethinyl Estradiol; D002766:Cholecystokinin; C035144:drospirenone