title: Novel therapeutic options in inflammatory cardiomyopathy.
abstract: Inflammatory dilated cardiomyopathy (iDCM) denotes cardiac dysfunction due to myocardial inflammation (myocarditis). Progressively impaired cardiac contractility, fibrosis and dilation of heart chambers characterise iDCM phenotypically, and are associated with poor clinical prognosis. Cardiotropic infections followed by autoimmune responses against heart tissue are the most common cause of iDCM. The pathophysiology of iDCM is still poorly understood. Nevertheless, our understanding of the molecular mechanisms of inflammatory heart failure advanced during recent years. In fact, recent mechanistic insights might open the view for novel diagnostic and therapeutic approaches for iDCM patients in the future. In this review we update our knowledge on disease mechanisms, summarise current clinical approaches for iDCM patients, and discuss future therapeutic options.
authors.affiliation: Cardioimmunology, Cardiovascular Research, Institute of Physiology , ZÃ¼rich, SWITZERLAND; gabriela.kania@uzh.ch.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kania
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Blyszczuk
authors.forename: Björn
authors.initials: B
authors.lastname: Müller-Edenborn
authors.forename: Urs
authors.initials: U
authors.lastname: Eriksson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000150:complications; D058406:Cardiac Resynchronization Therapy; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D003141:Communicable Diseases / Q000150:complications; D017147:Defibrillators, Implantable; D004232:Diuretics / Q000627:therapeutic use*; D042241:Early Diagnosis; D061345:Early Medical Intervention; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use*; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D009205:Myocarditis / Q000150:complications / Q000276:immunology*; D020257:Ventricular Remodeling
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D000451:Mineralocorticoid Receptor Antagonists; D016899:Interferon-beta