title: pT2 Adenocarcinoma of the esophagus: early or advanced cancer?
abstract: BACKGROUND
  There is an increasing trend to include patients with esophageal carcinoma invading the muscularis propria (pT2) in neoadjuvant therapy regimens. But it is unclear which patients have prognostic benefit from this strategy. The aim of this study was to assess the prognosis and prognostic factors in patients with pT2 esophageal adenocarcinoma to further optimize treatment strategies.
  
  
  METHODS
  Included were patients with pT2 esophageal adenocarcinoma treated operatively at three centers specializing in upper gastrointestinal surgery. There were 159 patients (139 male) without induction therapy; median age was 64.5 years. Survival was analyzed by univariate and multivariate analysis.
  
  
  RESULTS
  In 37% of patients (n = 59), no lymph node involvement (pN0) was detected. Overall 5-year survival rate for all patients was 37%; for pN0 patients it was 62%, and for patients with lymph node metastases (pN+) it was 24%. Median number of examined lymph nodes was 26. Extracapsular lymph node involvement (ELNI) was evident in 55 of 100 pN+ patients with a 5-year survival rate of 14%. Patients without ELNI had a 5-year survival rate of 36% (p = 0.041). Results were comparable in all participating hospitals. Thirty-day and 90-day mortality rates of the entire collective were 2.6% and 3.8%, respectively. Multivariate analysis of prognosis revealed the lymph node ratio (p < 0.001) and the pN-ELNI category (p = 0.005) as significant parameters (pN0 hazard ratio 1 [reference]; pN+ without ELNI hazard ratio 2.2, 95% confidence interval: 1.2 to 3.8); pN+ with ELNI hazard ratio 2.5, 95% confidence interval: 1.5 to 4.5).
  
  
  CONCLUSIONS
  The prognosis of patients with esophageal adenocarcinoma invading the muscularis propria without lymph node metastasis is very good. However, in this study, about 30% had extracapsular lymph node involvement, which reflects particularly aggressive biological tumor behavior.
authors.affiliation: Department of General, Visceral, and Cancer Surgery, University of Cologne, Cologne, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Metzger
authors.forename: Dietmar
authors.initials: D
authors.lastname: Lorenz
authors.forename: Ines
authors.initials: I
authors.lastname: Gockel
authors.forename: Judith
authors.initials: J
authors.lastname: Origer
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Plum
authors.forename: Theodor
authors.initials: T
authors.lastname: Junginger
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.forename: Torsten
authors.initials: T
authors.lastname: Hansen
authors.forename: Kristina
authors.initials: K
authors.lastname: Krümpelmann
authors.forename: Annette
authors.initials: A
authors.lastname: Fisseler-Eckhoff
authors.forename: Hauke
authors.initials: H
authors.lastname: Lang
authors.forename: Arnulf H
authors.initials: AH
authors.lastname: Hölscher
authors.forename: Elfriede
authors.initials: E
authors.lastname: Bollschweiler
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: 7