title: Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives.
abstract: A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines.
authors.affiliation: Department of Drug and Natural Product Synthesis, University of Vienna, Vienna, Austria.
authors.forename: Theerachart
authors.initials: T
authors.lastname: Leepasert
authors.forename: Manochehr
authors.initials: M
authors.lastname: Shahabi
authors.forename: Karem
authors.initials: K
authors.lastname: Shanab
authors.forename: Eva
authors.initials: E
authors.lastname: Schirmer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Holzer
authors.forename: Helmut
authors.initials: H
authors.lastname: Spreitzer
authors.forename: Babette
authors.initials: B
authors.lastname: Aicher
authors.forename: Gilbert
authors.initials: G
authors.lastname: Müller
authors.forename: Eckhard
authors.initials: E
authors.lastname: Günther
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005449:Fluorenes / Q000138:chemical synthesis*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D001372:Aza Compounds; D001555:Benzene Derivatives; D005449:Fluorenes
keywords: Anticancer compounds