title: New lignan esters from Alyxia schlechteri and antifungal activity against Pythium insidiosum.
abstract: Three new lignan esters, alyterinates A-C (1-3), as well as 10 known compounds were isolated from the roots of Alyxia schlechteri. Antifungal activity against Pythium insidiosum of all lignan derivatives was evaluated using disk diffusion assay. P. insidiosum is not a true fungus since its cell walls do not contain ergosterol as usual fungi, so the antifungals available now are not effective. From activity testing, it was found that compounds 3, 4 and 5 could inhibit the mycelia growth of P. insidiosum.
authors.affiliation: Department of Science and Technology, Faculty of Liberal Arts and Science, Roi-Et Rajabhat University, Selapoom, Roi-Et 45120, Thailand.
authors.forename: Uraiwan
authors.initials: U
authors.lastname: Sriphana
authors.affiliation: Department of Microbiology, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University 40002, Thailand.
authors.forename: Yordhathai
authors.initials: Y
authors.lastname: Thongsri
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Pispong
authors.initials: P
authors.lastname: Ardwichai
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Kitisak
authors.initials: K
authors.lastname: Poopasit
authors.affiliation: Department of Microbiology, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University 40002, Thailand.
authors.forename: Chularut
authors.initials: C
authors.lastname: Prariyachatigul
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Sontaya
authors.initials: S
authors.lastname: Simasathiansophon
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: chayen@kku.ac.th.
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D011775:Pythium / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D017705:Lignans; D010936:Plant Extracts
keywords: Alyterinates A−C; Alyxia schlechteri; Lignans; Pythium insidiosum