title: Immediate graft histological assay, post pig's liver transplantation.
abstract: OBJECTIVE
  To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs.
  
  
  METHODS
  Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3.
  
  
  RESULTS
  Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7.
  
  
  CONCLUSIONS
  The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
authors.affiliation: Department of Integrate Health, Medical School, Para State University (UEPA), Brazil. marcusvhbrito@gmail.com
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
authors.forename: Marialva Tereza Ferreira de
authors.initials: MT
authors.lastname: Araújo
authors.forename: Luane Cristine Batista
authors.initials: LC
authors.lastname: Cunha
authors.forename: Antônio Jorge Barbosa de
authors.initials: AJ
authors.lastname: Oliveira
authors.forename: Jacqueline Barreto
authors.initials: JB
authors.lastname: Rodrigues
authors.forename: Nathalya Botelho
authors.initials: NB
authors.lastname: Brito
mesh_terms: D000818:Animals; D001706:Biopsy; D005234:Fatty Liver; D005260:Female; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation / Q000379:methods*; D023421:Models, Animal; D009336:Necrosis; D011168:Portal System / Q000473:pathology; D011183:Postoperative Complications; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors