title: Effect of low refocusing angle in T1-weighted spin echo and fast spin echo MRI on low-contrast detectability: a comparative phantom study at 1.5 and 3 Tesla.
abstract: MRI tissue contrast is not well preserved at high field. In this work, we used a phantom with known, intrinsic contrast (3.6%) for model tissue pairs to test the effects of low angle refocusing pulses and magnetization transfer from adjacent slices on intrinsic contrast at 1.5 and 3 Tesla. Only T1-weighted spin echo sequences were tested since for such sequences the contrast loss, tissue heating, and image quality degradation at high fields seem to present significant diagnostic and quality issues. We hypothesized that the sources of contrast loss could be attributed to low refocusing angles that do not fulfill the Hahn spin echo conditions or to magnetization transfer effects from adjacent slices in multislice imaging. At 1.5 T the measured contrast was 3.6% for 180° refocusing pulses and 2% for 120° pulses, while at 3 T, it was 4% for 180° and only 1% for 120° refocusing pulses. There was no significant difference between single slice and multislice imaging suggesting little or no role played by magnetization transfer in the phantom chosen. Hence, one may conclude that low angle refocusing pulses not fulfilling the Hahn spin echo conditions are primarily responsible for significant deterioration of T1-weighted spin echo image contrast in high-field MRI.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. ssarkar@bidmc.harvard.edu
authors.forename: Subhendra N
authors.initials: SN
authors.lastname: Sarkar
authors.forename: Jason L
authors.initials: JL
authors.lastname: Mangosing
authors.forename: Pooja R
authors.initials: PR
authors.lastname: Sarkar
mesh_terms: D003287:Contrast Media; D017352:Echo-Planar Imaging; D006801:Humans; D019047:Phantoms, Imaging; D059629:Signal-To-Noise Ratio; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels