title: The impact of traumatic brain injury on pituitary function.
abstract: It is paramount that clinicians who care for patients with traumatic brain injury (TBI) at any point in time, including neurosurgeons, rehabilitation physicians, internists, neurologists, and endocrinologists, are aware of the prevalence of posttraumatic hypopituitarism and its impacts on acute and long-term recovery. This article reviews the natural history, pathophysiology, and presenting features of hypopituitarism occurring after TBI. Proposed methodologies for screening, diagnosis, and initiation of treatment are discussed, as well as the effect of hormone replacement therapy on clinical outcomes.
authors.affiliation: Division of Endocrinology, Diabetes, and Bone Disease, Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1055, New York, NY 10029, USA. eliza.geer@mssm.edu
authors.forename: Nina K
authors.initials: NK
authors.lastname: Sundaram
authors.forename: Eliza B
authors.initials: EB
authors.lastname: Geer
authors.forename: Brian D
authors.initials: BD
authors.lastname: Greenwald
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology*; D006801:Humans; D007018:Hypopituitarism / Q000503:physiopathology*
keywords: Diagnosis; Hormone replacement therapy; Hypopituitarism; Neurocognitive impairment; Outcome; Pathophysiology; Screening; Traumatic brain injury