title: Gelation kinetics and viscoelastic properties of pluronic and α-cyclodextrin-based pseudopolyrotaxane hydrogels.
abstract: The results of a systematic investigation into the gelation behavior of α-cyclodextrin (α-CD) and Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers) pseudopolyrotaxane (PPR) hydrogels are reported here in terms of the effects of temperature, α-CD concentration, and Pluronic type (Pluronic F68 and Pluronic F127). It was found that α-CD significantly modifies the gelation behavior of Pluronic solutions and that the PPR hydrogels are highly sensitive to changes in the α-CD concentration. In some cases, the addition of α-CD was found to be detrimental to the gelation process, leading to slower gelation kinetics and weaker gels than with Pluronic alone. However, in other cases, the hydrogels formed in the presence of the α-CDs reached higher moduli and showed faster gelation kinetics than with Pluronic alone and in some instances α-CD allowed the formation of hydrogels from Pluronic solutions that would normally not undergo gelation. Depending on composition and ratio of α-CD/Pluronic, these highly viscoelastic hydrogels displayed elastic shear modulus values ranging from 2 kPa to 7 MPa, gelation times ranging from a few seconds to a few hours and self-healing behaviors post failure. Using dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS), we probed the resident structure of these systems, and from these insights we have proposed a new molecular mechanism that accounts for the macroscopic properties observed.
authors.affiliation: Tissue Engineering and Microfluidics Laboratory, Australian Institute for Bioengineering and Nanotechnology, ‡Centre for Microscopy and Microanalysis, §School of Chemistry and Molecular Biosciences, and ∥The School of Chemical Engineering, The University of Queensland , St. Lucia, 4072 Australia.
authors.forename: Clementine
authors.initials: C
authors.lastname: Pradal
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Jack
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Grøndahl
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Cooper-White
mesh_terms: D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D020442:Poloxamer / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012212:Rheology; D013696:Temperature; D013997:Time Factors; D014783:Viscosity; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D005782:Gels; D020100:Hydrogels; D047391:alpha-Cyclodextrins; D020442:Poloxamer; D011092:Polyethylene Glycols; C032613:alpha-cyclodextrin