title: Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single-embryo transfer for infertile women with advanced maternal age.
abstract: The universal goal of assisted reproduction technologies is a singleton delivery of a healthy full-term baby. For younger women (<35 years of age) single-embryo transfer is a viable option resulting in clinical success similar to multiple-embryo transfers. In contrast, older women have significantly lower pregnancy rates following single-embryo transfer. To provide effective single-embryo transfer options for older women, improved methods of embryo selection are required to overcome the marked differences in outcome of single- versus double-embryo transfer. With the development of comprehensive chromosome screening, blastocyst vitrification, and trophectoderm biopsy techniques, older women have the opportunity of elective single-embryo transfer with live birth rates as high as those reported for younger good-prognosis infertility patients.
authors.affiliation: Colorado Center for Reproductive Medicine, Lone Tree, Colorado 80124, USA. bschoolcraft@colocrm.com
authors.forename: William B
authors.initials: WB
authors.lastname: Schoolcraft
authors.forename: Mandy G
authors.initials: MG
authors.lastname: Katz-Jaffe
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000196:embryology; D020732:Cytogenetic Analysis / Q000379:methods; D004475:Ectoderm / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008423:Maternal Age; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods; D056826:Single Embryo Transfer / Q000379:methods; D014327:Trophoblasts / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D058989:Vitrification
keywords: Comprehensive chromosome screening; blastocyst; single-embryo transfer; vitrification