title: An efficient combinatorial synthesis of allocolchicine analogues via a triple cascade reaction and their evaluation as inhibitors of insulin aggregation.
abstract: A controlled cascade: A divergent, diastereoselective and efficient one-pot synthesis of allocolchicinoids via a cascade Suzuki-Michael addition-Carbocyclization sequence is described. The utility of the compounds as possible inhibitors of insulin aggregation is also presented.
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Rd, Lucknow 226031 (India).
authors.forename: Subhendu
authors.initials: S
authors.lastname: Bhowmik
authors.forename: Shruti
authors.initials: S
authors.lastname: Khanna
authors.forename: Kumkum
authors.initials: K
authors.lastname: Srivastava
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hasanain
authors.forename: Jayanta
authors.initials: J
authors.lastname: Sarkar
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
authors.forename: Sanjay
authors.initials: S
authors.lastname: Batra
mesh_terms: D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D003078:Colchicine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D007329:Insulin Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D007329:Insulin Antagonists; C032782:allocolchicine; D003078:Colchicine
keywords: alkaloids; antiaggregation agents; cascade reactions; natural products; one-pot syntheses