title: Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.
abstract: Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.
authors.affiliation: Department of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA.|Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA.|Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
authors.forename: Annie Y
authors.initials: AY
authors.lastname: Chan
authors.affiliation: Department of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA.|Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
authors.forename: Donald U
authors.initials: DU
authors.lastname: Stone
authors.affiliation: Department of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA.|Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
authors.forename: Nawajes A
authors.initials: NA
authors.lastname: Mandal
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000378:metabolism; D012162:Retinal Degeneration / Q000175:diagnosis* / Q000378:metabolism; D013106:Sphingolipidoses / Q000175:diagnosis* / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism; D015866:Uveitis, Posterior / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D013107:Sphingolipids
keywords: FTY720; ceramide; retina; retinal degenerations; sphingolipid; sphingosine; uveitis