title: PSCA and Oct-4 expression in the benign and malignant lesions of gallbladder: implication for carcinogenesis, progression, and prognosis of gallbladder adenocarcinoma.
abstract: PSCA and Oct-4 have been thought as markers of cancer stem cells. Although overexpression of PSCA and Oct-4 in cancer has been reported, little is known about the clinical and pathological significance with PSCA and Oct-4 expression in gallbladder adenocarcinoma. In this study, overexpression of PSCA and Oct-4 was detected in gallbladder adenocarcinoma (54.6% and 55.6%). Less expression of PSCA and Oct-4 was detected in the pericancerous tissues (19.6% and 21.7%), gallbladder polyps (13.3% and 13.3%), and gallbladder epithelium with chronic cholecystitis (14.3% and 14.3%). The overexpression of PSCA and Oct-4 was significantly associated with differentiation, tumor mass, lymph node metastasis, invasion of gallbladder adenocarcinoma, and decreased overall survival. Our study suggested that overexpression of PSCA and Oct-4 might be closely related to the carcinogenesis, progression, metastasis, or invasive potential and prognosis of gallbladder carcinoma.
authors.affiliation: Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zou
authors.forename: Leping
authors.initials: L
authors.lastname: Yang
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Yang
authors.forename: Jiangsheng
authors.initials: J
authors.lastname: Huang
authors.forename: Xi
authors.initials: X
authors.lastname: Fu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000378:metabolism*; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; C110843:PSCA protein, human