title: Etiology of valvular heart disease in the 21st century.
abstract: A metamorphosis in the etiology of valvular heart disease (VHD) has occurred over the last 6 decades. In this review, the factors contributing to this metamorphosis, the common causes of VHD today, the relationship of valvular calcification to atherosclerosis and the interrelationship of VHD with other systems/organs are presented.
authors.affiliation: Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Konstantinos Dean
authors.initials: KD
authors.lastname: Boudoulas
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Borer
authors.forename: Harisios
authors.initials: H
authors.lastname: Boudoulas
mesh_terms: D002114:Calcinosis / Q000209:etiology; D009202:Cardiomyopathies / Q000209:etiology; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004198:Disease Susceptibility / Q000209:etiology; D004696:Endocarditis / Q000209:etiology; D005260:Female; D006338:Heart Neoplasms / Q000209:etiology; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D010375:Pedigree; D051436:Renal Insufficiency, Chronic / Q000209:etiology
chemical_list: D002317:Cardiovascular Agents