title: [Rapid simultaneous screening and detection of ten anticoagulant rodenticides in foods by ultra-high performance liquid chromatography-tandem mass spectrometry].
abstract: A rapid method for the simultaneous screening and detection of ten anticoagulant rodenticides in foods was developed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). After the extraction by acetonitrile and clean-up by QuEChERS, the extract was separated on a Poroshell 120 EC-C18 column (100 mm x 2.1 mm, 2.7 microm) with the gradient elution of 5 mmol/L ammonium acetate and acetonitrile. The detection was carried out by UPLC-MS/MS using a negative electrospray ionization interface in multiple reaction monitoring (MRM) mode. The ten anticoagulant rodenticides showed a good linear relationship (r > 0.99) in the range of 5 - 500 microg/L. In the four samples of chili sauce, flour, vinegar and soy sauce, the spiked recoveries were in the range of 72.6% - 112%, and the relative standard deviations (RSD) were all not more than 11.2%. The limits of detection (LOD) were all in the range of 0.5 - 4.5 microg/kg. This method is rapid, simple, sensitive, accurate and of good specificity for the satisfactory rapid screening and detection of the ten anticoagulant rodenticides in the sudden public health security events.
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Hualiang
authors.initials: H
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Chen
authors.forename: Weiguang
authors.initials: W
authors.lastname: Rong
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000925:Anticoagulants / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D012378:Rodenticides / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D000925:Anticoagulants; D012378:Rodenticides