title: Syntheses and anti-tubercular activity of β-substituted and α,β-disubstituted peptidyl β-aminoboronates and boronic acids.
abstract: Tuberculosis is still affecting millions of people worldwide, and new resistant strains of Mycobacterium tuberculosis are being found. It is therefore necessary to find new compounds for treatment. In this paper, we report the synthesis and in vitro testing of peptidyl β-aminoboronic acids and β-aminoboronates with anti-tubercular activity.
authors.affiliation: Department of Chemistry, University of Tromsø, N-9037, Tromsø, Norway.
authors.forename: Alexey S
authors.initials: AS
authors.lastname: Gorovoy
authors.forename: Olga
authors.initials: O
authors.lastname: Gozhina
authors.forename: John-Sigurd
authors.initials: JS
authors.lastname: Svendsen
authors.forename: George V
authors.initials: GV
authors.lastname: Tetz
authors.forename: Anna
authors.initials: A
authors.lastname: Domorad
authors.forename: Victor V
authors.initials: VV
authors.lastname: Tetz
authors.forename: Tore
authors.initials: T
authors.lastname: Lejon
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001897:Boronic Acids / Q000737:chemistry*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000995:Antitubercular Agents; D001897:Boronic Acids
keywords: Matteson homologation; antibacterial peptides; beta-aminoboronates; beta-aminoboronic acids; peptidyl beta-aminoboronates; peptidyl beta-aminoboronic acids; tuberculosis