title: A cytotoxic decahydronaphthalenylpropenal derivative and tetrahydrofuran lignans from the stems ofCameraria latifolia.
abstract: A new decahydronaphthalenylpropenal derivative, (+)-camerarialdehyde (1), a new tetrahydrofuran lignan, (-)-diepiolivil (2), and two known lignans were isolated from a methanol-soluble extract of the stems ofCameraria latifolia, which was obtained from a repository donated to IHVR by Merck Research Laboratories. The structures of compounds1and2were determined by interpretation of their spectroscopic data, with the absolute configuration of1being established by analysis of its CD spectrum. The absolute configuration of the 1,3-diol moiety of2was proposed from the CD spectrum induced with dimolybdenum tetraacetate in DMSO solution. All compounds isolated were evaluated against HT-29 human colon cancer cells, and compound1was found to show cytotoxicity toward this cell line.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ren
authors.forename: Heebyung
authors.initials: H
authors.lastname: Chai
authors.forename: Michael
authors.initials: M
authors.lastname: Goetz
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
keywords: CD spectrum induced by dimolybdenum tetraacetate; Cameraria latifolia; decahydronaphthalenylpropenal derivative; tetrahydrofuran lignans