title: Loss of CCR4 antigen expression after mogamulizumab therapy in a case of adult T-cell leukaemia-lymphoma.
authors.affiliation: Department of Haematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. nobuohno@ims.u-tokyo.ac.jp.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohno
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ishigaki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yuji
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Koota
authors.initials: K
authors.lastname: Sato
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Watanabe
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
authors.forename: Kaoru
authors.initials: K
authors.lastname: Uchimaru
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D002999:Clone Cells / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage; D015536:Down-Regulation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D054398:Receptors, CCR4 / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D014750:Vincristine / Q000008:administration & dosage; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C515354:CCR4 protein, human; D009363:Neoplasm Proteins; D009607:Nitrosourea Compounds; D054398:Receptors, CCR4; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin; D014751:Vindesine; C020766:ranimustine; D011241:Prednisone; C549035:mogamulizumab
keywords: CC chemokine receptor 4; adult T-cell leukaemia-lymphoma; flow cytometry; mogamulizumab; monoclonal antibody