title: Predictors of survival in hepatitis B virus related decompensated cirrhosis on tenofovir therapy: an Indian perspective.
abstract: Decompensated cirrhosis has low survival rate compared to compensated state. Effective viral suppression due to antiviral therapy (tenofovir) has been shown to slow disease progression and may delay the burden of liver transplantation. We aimed to evaluate the usefulness of various prognostic indicators in predicting the 24-months survival in HBV related decompensated cirrhosis after tenofovir therapy and to evaluate the post-treatment outcome. Ninety-six HBV related decompensated patients on antiviral (tenofovir) therapy were prospectively studied for 24months survival and mortality. Cutoff levels for several prognostic indicators were generated by ROC. Prediction of overall probability of mortality was also calculated. The overall probability of survival observed at 12months was 0.947 whereas at 24months it was found to be 0.833. According to Cox proportional hazards model, the univariate analysis revealed cutoff of >7.4logcopies/ml for HBV DNA, >1.2mg/dl for serum creatinine, >3.7mg/dl for total bilirubin, ⩽0.75 for platelets count, >10 for CTP and >20 for MELD as predictors of poor survival. Multivariate analysis showed MELD score of >20 was the most robust predictor of mortality, with 58 times higher risk (HR: 58.73, p<0.001). Post-treatment response with tenofovir for 24months significantly improved the hepatic functions and reverses decompensation and showed incredible efficacy in improvement of hepatic functional status with reduced viremia in a great majority of decompensated cirrhosis subjects having high MELD and HBV DNA level.
authors.affiliation: Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, U.P., India.
authors.forename: Manjita
authors.initials: M
authors.lastname: Srivastava
authors.forename: Sumit
authors.initials: S
authors.lastname: Rungta
authors.forename: V K
authors.initials: VK
authors.lastname: Dixit
authors.forename: S K
authors.initials: SK
authors.lastname: Shukla
authors.forename: T B
authors.initials: TB
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Jain
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D003404:Creatinine / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000401:mortality*; D006801:Humans; D007194:India; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000401:mortality*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D010976:Platelet Count; D011446:Prospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D000068698:Tenofovir; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D063065:Organophosphonates; D000068698:Tenofovir; D003404:Creatinine; D000225:Adenine; D001663:Bilirubin
keywords: Antivirals; Decompensated cirrhosis; HE; MELD; Mortality; Prognostic predictor; Survival; Tenofovir