title: Leptin, GABA, and glucose control.
abstract: Leptin mimics many of the antidiabetic actions of insulin in insulin-deficient diabetes, but the mechanism is controversial. Fujikawa et al. (2013) reveal that leptin receptors in γ-aminobutyric acid (GABA)-ergic and pro-opiomelanocortin (POMC) neurons in the central nervous system are sufficient to mediate the lifesaving and antidiabetic actions of leptin in insulin-deficient mice.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address: bkahn@bidmc.harvard.edu.
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Kahn
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Minokoshi
mesh_terms: D000818:Animals; D007031:Hypothalamus / Q000187:drug effects*; D007328:Insulin / Q000378:metabolism*; D020738:Leptin / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*
chemical_list: D007328:Insulin; D020738:Leptin