title: [Is the Down syndrome a primary immunodeficiency?].
abstract: Down syndrome is associated with changes characteristic of primary immunodeficiencies, such as susceptibility to infection, autoimmunity and malignancy risk. However, it is not considered a primary immunodeficiency but rather a syndromatic deficiency, due to the relevance of the characteristic neurological delay. This article presents some arguments that consider Down syndrome as a primary immunodeficiency.
authors.affiliation: Servicio InmunologÌa ClÌnica, Hospital Infantil del Estado de Chihuahua, Avenida Matamoros 2239, colonia Cuarteles, Chihuahua Chih, MÈxico.
authors.forename: Luisa Berenise
authors.initials: LB
authors.lastname: Gómez-González
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Yamazaki-Nakashimada
mesh_terms: D015551:Autoimmunity; D004314:Down Syndrome; D006801:Humans; D007153:Immunologic Deficiency Syndromes