title: Management of rosacea-prone skin: evaluation of a skincare product containing Ambophenol, Neurosensine, and La Roche-Posay Thermal spring water as monotherapy or adjunctive therapy.
abstract: OBJECTIVE
  The objective of these studies was to investigate whether a skincare product containing Ambophenol, Neurosensine, and La Roche-Posay thermal spring water formulated in a highly protective packaging can have an impact in the management of rosacea-prone skin subjects.
  
  
  METHODS
  Several studies were performed to evaluate the efficacy of this product in the management of rosacea prone skin, as either monotherapy or adjunctive therapy or to maintain the efficacy of a Metronidazole treatment. The first study was performed on 37 women aged 18-45 with added stage 2 erythro-couperosis, who applied test formula as monotherapy twice a day for 4 weeks. During a second study, a dermatological evaluation was performed on patients with stage I or II rosacea, a questionnaire containing information about patient characteristics, tolerance, clinical signs, symptoms and skin reactivity to "trigger factors" was completed by dermatologists at baseline and 2 months after treatment with the test formula as either monotherapy or adjunctive therapy. Finally, in a third study, 65 patients finishing a Metronidazole treatment applied once daily and the tested formula twice daily were divided into 2 groups using the test formula or vehicle control, twice a day for 8 weeks for the evaluation of efficacy as adjunctive therapy.
  
  
  RESULTS
  We noted that the test formula, as an adjunctive therapy, helped prolong the efficacy of a Metronidazole treatment. In monotherapy, there was a significant efficacy of the test formula associated with an excellent tolerance. A significant improvement of all the clinical signs and symptoms of rosacea and a reduction of the skin reactivity to "trigger factors" were shown.
  
  
  CONCLUSIONS
  These studies highlight the interest value and impact of a skincare product containing Ambophenol, Neurosensine, and La Roche-Posay thermal spring water formulated in a highly protective packaging in monotherapy or in combination with or after a therapeutic treatment in the management of patients suffering from rosacea.
authors.forename: Sophie
authors.initials: S
authors.lastname: Seite
authors.forename: Florence
authors.initials: F
authors.lastname: Benech
authors.forename: Sandrine
authors.initials: S
authors.lastname: Berdah
authors.forename: Muriel
authors.initials: M
authors.lastname: Bayer
authors.forename: Sophie
authors.initials: S
authors.lastname: Veyrat
authors.forename: Evelyne
authors.initials: E
authors.lastname: Segot
authors.forename: Marcela
authors.initials: M
authors.lastname: Sakalikova
authors.forename: Lucia
authors.initials: L
authors.lastname: Gibejova
authors.forename: Hana
authors.initials: H
authors.lastname: Zelenkova
mesh_terms: D000293:Adolescent; D000328:Adult; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004349:Drug Packaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D008900:Mineral Waters / Q000008:administration & dosage; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D017592:Skin Care / Q000379:methods*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D008900:Mineral Waters; D010936:Plant Extracts; D008795:Metronidazole