title: [Reversal of rocuronium induced neuromuscular block with sugammadex in a patient with myasthenia gravis].
abstract: We report a patient with myasthenia gravis whose rocuronium induced neuromuscular block was reversed with sugammadex. A 26-year-old man, 175 cm and 76 kg, with myasthenia gravis, was scheduled for extended thymectomy under general anesthesia. An epidural catheter was inserted at the T5-6 interspace before induction of general anesthesia. Anesthesia was induced with propofol and remifentanil. Rocuronium was given in divided doses to obtain > 95% neuromuscular block to intubate the trachea. The ED50 and ED95 of rocuronium for this patient were 0.18 mg x kg(-1) and 0.39 mg x kg(-1), respectively. The values were similar to the ED50 and ED95 of rocuronium for normal patients. General anesthesia was maintained with propofol and remifentanil. Additional doses of rocuronium were given intermittently. Sugammadex, 2 mg x kg(-1), was given at the end of the surgery. The train-of-four ratio reached 93% 105 sec later. His postoperative course was uneventful.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180.
authors.forename: Erisa
authors.initials: E
authors.lastname: Nakamori
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nitahara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sugi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Katori
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsuzaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Higa
mesh_terms: D000328:Adult; D000732:Androstanols / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000503:physiopathology*; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D000077123:Rocuronium; D000077122:Sugammadex; D013934:Thymectomy; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium