title: Relationships between skin cancers and blood groups--link between non-melanomas and ABO/Rh factors.
abstract: BACKGROUND
  This investigation focused on possible relationships between skin cancers and ABO/Rh blood groups.
  
  
  METHODS
  Between January 2005 and December 2012, medical data of 255 patients with skin cancers who were admitted to Kayseri Training and Research Hospital, Radiation Oncology and Plastic Surgery Outpatient Clinics were retrospectively analyzed. Blood groups of these patients were recorded. The control group consisted of 25701 healthy volunteers who were admitted to Kayseri Training and Research Hospital, Blood Donation Center between January 2010 and December 2011. The distribution of the blood groups of the patients with skin cancers was compared to the distribution of ABO/Rh blood groups of healthy controls. The association of the histopathological subtypes of skin cancer with the blood groups was also investigated.
  
  
  RESULTS
  Of the patients, 50.2% had A type, 26.3% had O type, 16.1% had B type, and 7.5% had AB blood group with a positive Rh (+) in 77.3%. Of the controls, 44.3% had A type, 31.5% had 0 type, 16.1% had B type, and 8.1% had AB blood group with a positive Rh (+) in 87.8%. There was a statistically significant difference in the distribution of blood groups and Rh factors (A Rh (-) and 0 Rh positive) between the patients and controls. A total of 36.8% and 20.4% of the patients with basal cell carcinoma (BCC) had A Rh (+) and B Rh (+), respectively, while 39.2% and 27.6% of the controls had A Rh (+) and B Rh (+), respectively. A significant relationship was observed between the patients with BCC and controls in terms of A Rh (-) (p=0.001).
  
  
  CONCLUSIONS
  Our study results demonstrated that there is a significant relationship between non-melanoma skin cancer and ABO/Rh factors.
authors.affiliation: Department of Radiation Oncology, Cumhuriyet University Gemerek Vocation School, Turkey. cihany@erciyes.edu.tr
authors.forename: Yasemin Benderli
authors.initials: YB
authors.lastname: Cihan
authors.forename: Halit
authors.initials: H
authors.lastname: Baykan
authors.forename: Erhan
authors.initials: E
authors.lastname: Kavuncuoglu
authors.forename: Hasan
authors.initials: H
authors.lastname: Mutlu
authors.forename: Mehmet Burhan
authors.initials: MB
authors.lastname: Kucukoglu
authors.forename: Kemal
authors.initials: K
authors.lastname: Ozyurt
authors.forename: Arzu
authors.initials: A
authors.lastname: Oguz
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002280:Basal Cell Carcinoma / Q000097:blood* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D008545:Melanoma / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D012204:Rh-Hr Blood-Group System / Q000097:blood*; D012878:Skin Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D000017:ABO Blood-Group System; D014408:Biomarkers, Tumor; D012204:Rh-Hr Blood-Group System