title: STROGAR - STrengthening the Reporting Of Genetic Association studies in Radiogenomics.
abstract: Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced in independent validation studies. A major reason for these inconsistencies is a high number of false positive findings because no adjustments were made for multiple comparisons. It is also possible that some validation studies were false negatives due to methodological shortcomings or a failure to reproduce relevant details of the original study. Transparent reporting is needed to ensure these flaws do not hamper progress in radiogenomics. In response to the need for improving the quality of research in the area, the Radiogenomics Consortium produced an 18-item checklist for reporting radiogenomics studies. It is recognised that not all studies will have recorded all of the information included in the checklist. However, authors should report on all checklist items and acknowledge any missing information. Use of STROGAR guidelines will advance the field of radiogenomics by increasing the transparency and completeness of reporting.
authors.affiliation: Department of Radiation Oncology, Mount Sinai School of Medicine, New York, USA; Department of Pathology, Albert Einstein College of Medicine, New York, USA; Department of Genetics, Albert Einstein College of Medicine, New York, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Kerns
authors.affiliation: Department of Radiation Oncology, University Hospitals Leuven/KU Leuven, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: de Ruysscher
authors.affiliation: Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.
authors.forename: Christian N
authors.initials: CN
authors.lastname: Andreassen
authors.affiliation: Montpellier Cancer Institute, Montpellier University, France.
authors.forename: David
authors.initials: D
authors.lastname: Azria
authors.affiliation: Department of Oncology, Cambridge University Hospital NHS Foundation Trust, UK.
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Barnett
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chang-Claude
authors.affiliation: Department of Clinical Oncology, Christie NHS Foundation Trust Hospital, Manchester, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Davidson
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Deasy
authors.affiliation: University of Cambridge, Strangeways Research Laboratories, UK.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, New York, USA; Department of Genetics, Albert Einstein College of Medicine, New York, USA.
authors.forename: Harry
authors.initials: H
authors.lastname: Ostrer
authors.affiliation: Department of Radiation Oncology, Mount Sinai School of Medicine, New York, USA.
authors.forename: Barry S
authors.initials: BS
authors.lastname: Rosenstein
authors.affiliation: Institute of Cancer Sciences, University of Manchester, UK.
authors.forename: Catharine M L
authors.initials: CM
authors.lastname: West
authors.affiliation: Department of Human Oncology, University of Wisconsin, Madison, USA. Electronic address: bentzen@humonc.wisc.edu.
authors.forename: Søren M
authors.initials: SM
authors.lastname: Bentzen
mesh_terms: D057189:Checklist / Q000379:methods* / Q000592:standards*; D056726:Genetic Association Studies; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000532:radiotherapy*; D020641:Polymorphism, Single Nucleotide; D017410:Practice Guidelines as Topic
keywords: Genetics; Normal tissue toxicity; Radiogenomics; Reporting guidelines