title: Emergence of a new lagovirus related to Rabbit Haemorrhagic Disease Virus.
abstract: Since summer 2010, numerous cases of Rabbit Haemorrhagic Disease (RHD) have been reported in north-western France both in rabbitries, affecting RHD-vaccinated rabbits, and in wild populations. We demonstrate that the aetiological agent was a lagovirus phylogenetically distinct from other lagoviruses and which presents a unique antigenic profile. Experimental results show that the disease differs from RHD in terms of disease duration, mortality rates, higher occurrence of subacute/chronic forms and that partial cross-protection occurs between RHDV and the new RHDV variant, designated RHDV2. These data support the hypothesis that RHDV2 is a new member of the Lagovirus genus. A molecular epidemiology study detected RHDV2 in France a few months before the first recorded cases and revealed that one year after its discovery it had spread throughout the country and had almost replaced RHDV strains. RHDV2 was detected in continental Italy in June 2011, then four months later in Sardinia.
authors.affiliation: Anses, French Agency for Food, Environmental and Occupational Health & Safety, Ploufragan-Plouzané Laboratory, Avian and Rabbit Virology, Immunology and Parasitology Unit, BP 53, 22440 Ploufragan, France. ghislaine.legall-recule@anses.fr.
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Le Gall-Reculé
authors.forename: Antonio
authors.initials: A
authors.lastname: Lavazza
authors.forename: Stéphane
authors.initials: S
authors.lastname: Marchandeau
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bertagnoli
authors.forename: Françoise
authors.initials: F
authors.lastname: Zwingelstein
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cavadini
authors.forename: Nicola
authors.initials: N
authors.lastname: Martinelli
authors.forename: Guerino
authors.initials: G
authors.lastname: Lombardi
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Guérin
authors.forename: Evelyne
authors.initials: E
authors.lastname: Lemaitre
authors.forename: Anouk
authors.initials: A
authors.lastname: Decors
authors.forename: Samuel
authors.initials: S
authors.lastname: Boucher
authors.forename: Bernadette
authors.initials: B
authors.lastname: Le Normand
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Capucci
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005602:France / Q000453:epidemiology; D006386:Hemagglutination Tests / Q000662:veterinary; D017929:Hemorrhagic Disease Virus, Rabbit / Q000737:chemistry / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D011817:Rabbits; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment / Q000662:veterinary; D015678:Viral Structural Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D015678:Viral Structural Proteins; C081149:viral protein 60, rabbit hemorrhagic disease virus