title: Nucleophagy at a glance.
abstract: Under certain circumstances, the removal of damaged or non-essential parts of the nucleus, or even an entire nucleus, is crucial in order to promote cell longevity and enable proper function. A selective form of autophagy, known as nucleophagy, can be used to accomplish the degradation of nucleus-derived material. In this Cell Science at a Glance article and the accompanying poster, we summarize the similarities and differences between the divergent modes of nucleophagy that have been described to date, emphasizing, where possible, the molecular mechanism, the membrane interactions and rearrangements, and the nature of the nucleus-derived material that is degraded. In turn, we will consider nucleophagy processes in the lower eukaryotes, the budding yeast Saccharomyces cerevisiae, filamentous fungi Aspergillus and Magnaporthe oryzae and the ciliated protozoan Tetrahymena thermophila, and finally in mammalian cells. We will also briefly discuss the emerging links between nucleophagy and human disease.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton campus, VIC 3800, Australia.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Mijaljica
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Devenish
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D006801:Humans