title: A comparative study of radiographic results using HEALOS collagen-hydroxyapatite sponge with bone marrow aspiration versus local bone graft in the same patients undergoing posterolateral lumbar fusion.
abstract: BACKGROUND
  Autologous bone harvested from the iliac crest is the gold standard for lumbar spinal fusion. However postoperative donor site pain and morbidity have been reported. Local bone graft is insufficient and contains some soft-tissue attachment. Therefore, Healos (DePuy Spine, Raynham, MA, USA) is currently bone graft substitute that was introduced for spinal fusion with good results but radiographic fusion rate has not been clearly defined yet.
  
  
  OBJECTIVE
  To assess the radiographic fusion rate of HEALOS with bone marrow aspiration versus autologous bone graft in the same patients undergoing posterolateral lumbar fusion.
  
  
  METHODS
  A retrospective radiographic outcome study of radiographic fusion rate from plain radiographs in 55patients indicatedforposterolateral lumbar fusion in Lerdsin General Hospital between April 2005 and December 2006 was done. The patients were implanted with HEALOS collagen-hydroxyapatite sponge with bone marrow aspiration and local bone graft on each side of Posterolateral Lumbar Fusion. Twenty-seven patients were included in the present study according to the authors'inclusion criteria. Plain radiographs were collected and radiographic fusion rate was assessed for at least two years follow-up.
  
  
  RESULTS
  The two years post operative radiographic fusion rate was 29.63% (8/27) in Healos/BMA group and 62.96% (17/27) in LBG group. At three-years follow-up, radiographic fusion rate of 36.84% (7/19) was achieved in the Healos/ BMA group and 78.93% (15/19) in the LBG group.
  
  
  CONCLUSIONS
  In the present study, Healos collagen-hydroxyapatite sponge with bone marrow aspiration had lower radiographic fusion rate when compared to local bone graft in posterolateral lumbar fusion at two years post operative. The results of the Healos/BMA group was increased fusion rate with time but remained lower than LBG group at three and four years follow-up.
authors.affiliation: Institute of Orthopaedics, Lerdsin General Hospital, Bangkok, Thailand. batkunakornsawat@gmail.com
authors.forename: Sombat
authors.initials: S
authors.lastname: Kunakornsawat
authors.forename: Arthithat
authors.initials: A
authors.lastname: Kirinpanu
authors.forename: Chaiwat
authors.initials: C
authors.lastname: Piyaskulkaew
authors.forename: Vera
authors.initials: V
authors.lastname: Sathira-Angkura
mesh_terms: D000368:Aged; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D016025:Bone Transplantation; D003094:Collagen / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000379:methods*
chemical_list: D018786:Bone Substitutes; C583670:Healos; D003094:Collagen; D017886:Durapatite