title: Seizures during high-dose antidepressant therapy: a case series with clinical and video-electroencephalography characteristics.
abstract: This case series identified drug causes of seizures in patients with depressive disorders. Three patients with seizures were admitted for video-electroencephalography (EEG) monitoring in the context of high-dose antidepressants and sodium valproate. Very high-dose antidepressants caused complex partial seizures with secondary generalisation that gave characteristic EEG discharges. This is the first reported series to capture the ictal EEG features associated with antidepressants.
authors.affiliation: Department of Medicine, St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, Australia. kathryn.ducharlet@svhm.org.au
authors.forename: K
authors.initials: K
authors.lastname: Ducharlet
authors.forename: U
authors.initials: U
authors.lastname: Seneviratne
authors.forename: L
authors.initials: L
authors.lastname: Sedal
authors.forename: M
authors.initials: M
authors.lastname: Salzberg
authors.forename: M
authors.initials: M
authors.lastname: Cook
authors.forename: W
authors.initials: W
authors.lastname: D'Souza
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D014741:Video Recording / Q000379:methods*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents
keywords: antidepressant; depression; epilepsy; video EEG