title: Th17 memory cells: live long and proliferate.
abstract: The development of immune memory is a double-edged sword, helping to maintain health by preventing repeated infections but also driving chronic inflammation when dysregulated. Th17 cells are now well-known as major drivers of autoimmune disease but also play roles in protective immune responses against pathogens. This mini-review will focus on the recent evidence for long-lived, robust Th17 memory cell populations in mouse models and humans, and their functional roles in mediating host protection and chronic disease states.
authors.affiliation: 1.Dept. of Medicine, Division of Rheumatology and Clinical Immunology, BST S719, 3500 Terrace St., Pittsburgh, PA 15261, USA. mmcgeach@pitt.edu.
authors.forename: Mandy J
authors.initials: MJ
authors.lastname: McGeachy
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000209:etiology; D008213:Lymphocyte Activation; D058504:Th17 Cells / Q000276:immunology*; D014611:Vaccination
keywords: CD4 T cell; IL-17; autoimmunity; pathogen