title: [Effect of atherosclerotic plaque on the contractility of human abdominal aorta sections].
abstract: The study was performed on 18 sections of the aneurysm-like abdominal aorta sampled during elective procedures of aneurysm correction in humans, and 10 sections of pig abdominal aorta. We examined the extent to which the presence of atherosclerotic plaque impaired the aorta contractile function and measured the thickness and weight of atherosclerosis plaque and arterial wall. We observed reduced tissue response to adrenaline in human aneurysm-like aorta in comparison to the control group. In the sections of human aorta devoid of atherosclerotic plaque the response to adrenaline was about 30% higher than in those with atherosclerotic changes but 35% lower than in normal aorta sections from pigs. The wall of aneurysm-like human aorta sections was thinner when compared to normal aorta.
authors.affiliation: Wrovasc-Zintegrowane Centrum Medycyny Sercowo-Naczyniowej, Wojewódzki Szpital Specjalistyczny, Ośrodek Badawczo-Rozwojowy we Wrocławiu.
authors.forename: Jan
authors.initials: J
authors.lastname: Gnus
authors.forename: Albert
authors.initials: A
authors.lastname: Czerski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Rusiecka
authors.forename: Willy
authors.initials: W
authors.lastname: Hauzer
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zawadzki
authors.forename: Stanisław
authors.initials: S
authors.lastname: Ferenc
mesh_terms: D000368:Aged; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology*; D013552:Swine
chemical_list: D004837:Epinephrine