title: A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects.
abstract: A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8'R)-acuminatolide (6), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher's esterification. The effect of compounds 1-7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Gyeongbuk, Korea.
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Choi
authors.forename: Yeon Ho
authors.initials: YH
authors.lastname: Choi
authors.forename: Ji Hyang
authors.initials: JH
authors.lastname: Kim
authors.forename: Hui-Hun
authors.initials: HH
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Sang Myung
authors.initials: SM
authors.lastname: Lee
authors.forename: Minkyun
authors.initials: M
authors.lastname: Na
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
mesh_terms: D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027443:Lindera / Q000737:chemistry*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D015850:Interleukin-6; D017705:Lignans; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C000595857:linderin A