title: Oxidative stress in mice treated with antileishmanial meglumine antimoniate.
abstract: In order to improve the understanding of the toxicity of pentavalent antimony (Sb(V)), we investigated the acute effects of meglumine antimoniate (MA) on the oxidative stress in heart, liver, kidney, spleen and brain tissue of mice. Levels of lipoperoxidation and protein carbonylation were measured to evaluate the oxidative status, whereas superoxide dismutase/catalase activity and glutathione levels were recorded to examine the antioxidative status. We observed that MA caused significant protein carbonylation in the heart, spleen and brain tissue. Increased lipoperoxidation was found in the liver and brain tissue. An imbalance between superoxide dismutase and catalase activities could be observed in heart, liver, spleen and brain tissue. Our results suggest that MA causes oxidative stress in several vital organs of mice. This indicates that the production of highly reactive oxygen and nitrogen species induced by MA might be involved in some of its toxic adverse effects.
authors.affiliation: Laboratório de Biologia Celular e Molecular, Unidade Acadêmica de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors.forename: D B
authors.initials: DB
authors.lastname: Bento
authors.forename: B
authors.initials: B
authors.lastname: de Souza
authors.forename: A V
authors.initials: AV
authors.lastname: Steckert
authors.forename: R O
authors.initials: RO
authors.lastname: Dias
authors.forename: D D
authors.initials: DD
authors.lastname: Leffa
authors.forename: S E
authors.initials: SE
authors.lastname: Moreno
authors.forename: F
authors.initials: F
authors.lastname: Petronilho
authors.forename: V M
authors.initials: VM
authors.lastname: de Andrade
authors.forename: F
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: P R
authors.initials: PR
authors.lastname: Romão
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000009:adverse effects / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000032:analysis; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000737:chemistry / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008536:Meglumine / Q000009:adverse effects / Q000494:pharmacology*; D000077485:Meglumine Antimoniate; D051379:Mice; D009206:Myocardium / Q000737:chemistry; D009942:Organometallic Compounds / Q000009:adverse effects / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D013154:Spleen / Q000737:chemistry / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Catalase; Lipoperoxidation; Meglumine antimoniate; Oxidative stress; Protein carbonylation; Superoxide dismutase