title: Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR-127 in human bladder cancer.
abstract: BACKGROUND
  Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs) that have critical roles in the regulation of gene expression.In this study, we aimed to predict potential mechanisms of bladder cancer related miRNAs and target genes by bioinformatics analyses.
  
  
  METHODS
  Here we used the method of text mining to identify nine miRNAs in bladder cancer and adopted protein-protein interaction analysis to identify interaction sites between these miRNAs and related-target genes.
  
  
  RESULTS
  There are two relationship types between bladder cancer and its related miRNAs: causal and unspecified. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment test showed that there were three pathways related to four miRNA targeted genes. The remaining five miRNAs annotated to disease are not enriched in the KEGG pathways. Of these, PIK3R1 is the overlapping gene among 38 genes in the cancer and bladder cancer pathways.
  
  
  CONCLUSIONS
  These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1.
authors.affiliation: Department of Urology, the 452nd Hospital of People's Liberation Army, Chengdu 610021, China. xuyahong@medmail.com.cn.
authors.forename: Yahong
authors.initials: Y
authors.lastname: Xu
authors.forename: Shunwen
authors.initials: S
authors.lastname: Luo
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Jia
authors.forename: Qihua
authors.initials: Q
authors.lastname: Zhao
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Ma
authors.forename: Minghui
authors.initials: M
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
mesh_terms: D001665:Binding Sites / Q000235:genetics; D058543:Class Ia Phosphatidylinositol 3-Kinase; D057225:Data Mining; D030541:Databases, Genetic; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000235:genetics*
chemical_list: D058543:Class Ia Phosphatidylinositol 3-Kinase; D035683:MicroRNAs; D019869:Phosphatidylinositol 3-Kinases; D012333:RNA, Messenger; C547276:MIRN127 microRNA, human; C588001:PIK3R1 protein, human