title: Sugar furanoid trans-vicinal diacid as a γ-turn inducer: synthesis and conformational study.
abstract: A simple method for the synthesis of a sugar furanoid trans vicinal diacid and its incorporation into the N-terminal tetrapeptide sequence (H-Phe-Trp-Lys-Thr-OH) to get glycopeptide has been described. 2D NMR and MD simulation studies of clearly show that the sugar diacid adopts a γ-turn conformation towards the N-terminus.
authors.affiliation: Department of Chemistry, Garware Research Centre, University of Pune, Pune, 411 007, India. ddd@chem.unipune.ac.in.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Vangala
authors.forename: Snehal A
authors.initials: SA
authors.lastname: Dhokale
authors.forename: Rupesh L
authors.initials: RL
authors.lastname: Gawade
authors.forename: Rajamohanan R
authors.initials: RR
authors.lastname: Pattuparambil
authors.forename: Vedavati G
authors.initials: VG
authors.lastname: Puranik
authors.forename: Dilip D
authors.initials: DD
authors.lastname: Dhavale
mesh_terms: D000143:Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation
chemical_list: D000143:Acids; D002241:Carbohydrates; D005663:Furans