title: RNA-mediated regulation in pathogenic bacteria.
abstract: Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors, and enable the bacteria to survive and proliferate after host infection. Regulatory RNAs are now recognized as important components of these networks, and their study may not only identify new approaches to combat infectious diseases but also reveal new general control mechanisms involved in bacterial gene expression. In this review, we illustrate the diversity of regulatory RNAs in bacterial pathogens, their mechanism of action, and how they can be integrated into the regulatory circuits that govern virulence-factor production.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, F-67084 Strasbourg, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Caldelari
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Chao
authors.forename: Pascale
authors.initials: P
authors.lastname: Romby
authors.forename: Jörg
authors.initials: J
authors.lastname: Vogel
mesh_terms: D001419:Bacteria / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000502:physiology; D005798:Genes, Bacterial / Q000235:genetics; D053038:Quorum Sensing / Q000502:physiology; D016372:RNA, Antisense / Q000502:physiology; D012329:RNA, Bacterial / Q000502:physiology*; D034741:RNA, Small Interfering / Q000378:metabolism; D058727:RNA, Small Untranslated / Q000502:physiology*; D038621:Regulatory Sequences, Ribonucleic Acid / Q000502:physiology; D015398:Signal Transduction; D037521:Virulence Factors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D016372:RNA, Antisense; D012329:RNA, Bacterial; D034741:RNA, Small Interfering; D058727:RNA, Small Untranslated; D038621:Regulatory Sequences, Ribonucleic Acid; D037521:Virulence Factors