title: Sebaceous carcinoma arising in mature cystic teratoma of ovary.
abstract: Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.
authors.affiliation: Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: An
authors.forename: Yong Han
authors.initials: YH
authors.lastname: Jung
authors.forename: Hye Kyoung
authors.initials: HK
authors.lastname: Yoon
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Jung
keywords: Mature cystic teratoma; Ovary; Sebaceous adenoma; Sebaceous carcinoma