title: Monosubstituted alkenyl amino acids for peptide "stapling".
abstract: Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
authors.affiliation: School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. A.J.Wilson@leeds.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Yeo
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Warriner
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wilson
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D051023:BH3 Interacting Domain Death Agonist Protein / Q000737:chemistry / Q000378:metabolism; D001896:Boron Compounds / Q000737:chemistry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000737:chemistry / Q000378:metabolism; D051020:bcl-X Protein / Q000737:chemistry / Q000378:metabolism
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000475:Alkenes; D000596:Amino Acids; D051023:BH3 Interacting Domain Death Agonist Protein; D001896:Boron Compounds; D010455:Peptides; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein