title: CXCL8 in thyroid disease: from basic notions to potential applications in clinical practice.
abstract: CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting results. Solid evidences support a role of CXCL8 as a tumor-promoting agent in several human cancers. Studies in thyroid cancer are still in their initial stage, but promising. Several evidences indicate that thyroid cancer may share with other human malignancies some of the effects of CXCL8 and highlight the possibility of using CXCL8 as a marker of aggressiveness. Basic and clinical evidences in favor or against a role for CXCL8 in thyroid diseases are discussed.
authors.affiliation: Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., Laboratory for Endocrine Disruptors and Chair of Endocrinology University of Pavia, Italy. Electronic address: mario.rotondi@fsm.it.
authors.forename: Mario
authors.initials: M
authors.lastname: Rotondi
authors.forename: Francesca
authors.initials: F
authors.lastname: Coperchini
authors.forename: Luca
authors.initials: L
authors.lastname: Chiovato
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D013959:Thyroid Diseases / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism
chemical_list: D016209:Interleukin-8
keywords: Autoimmune thyroid disease; CXCL8; Chemokines; Thyrocytes; Thyroid cancer