title: Cortical folding is altered before surgery in infants with congenital heart disease.
abstract: Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.
authors.affiliation: Department of Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, MO. Electronic address: ortinau_c@kids.wustl.edu.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ortinau
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
authors.forename: Donna
authors.initials: D
authors.lastname: Dierker
authors.forename: David
authors.initials: D
authors.lastname: Van Essen
authors.forename: John
authors.initials: J
authors.lastname: Beca
authors.forename: Terrie
authors.initials: T
authors.lastname: Inder
mesh_terms: D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities; D006179:Gyrus Cinguli / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D047929:Term Birth
keywords: CHD; CSA; Congenital heart disease; Cortical surface area; GI; Gyrification index; MRI; Magnetic resonance imaging