title: EMI1, a three-in-one ubiquitylation inhibitor.
abstract: The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor. New findings suggest that the multimodal inhibitory mechanisms of EMI1 control APC/C-dependent ubiquitylation.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamano
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D015703:Antigens, CD; D015820:Cadherins / Q000737:chemistry*; D018797:Cell Cycle Proteins / Q000737:chemistry*; D044783:F-Box Proteins / Q000737:chemistry*; D006801:Humans; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry*
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D018797:Cell Cycle Proteins; D044783:F-Box Proteins; C498960:FBXO5 protein, human; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome