title: Cardiometabolic risk factors in Iranians with spinal cord injury: analysis by injury-related variables.
abstract: Persons with spinal cord injury (SCI) have a high prevalence of abnormalities in carbohydrate and lipid metabolism. These abnormalities cause adverse coronary heart disease (CHD) in patients with SCI. In this study, we performed a detailed analysis of the level-specific cardiometabolic risk factors in individuals with SCI and analyzed the association of injury level on these risk factors. This was a cross-sectional study of 162 patients with SCI, assessing the prevalence of diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking. Fasting blood sugar (>100) was diagnosed in 27 patients (16.7%). Of the total patients, 36 (22.2%) had a total cholesterol (TC) level of >200. A triglyceride level of >150 was present in 56 patients (34.6%). Hypertension was present in 2.5% of the entire patient group. Body mass index (BMI), TC, and low-density lipoprotein cholesterol (LDL-C) were significantly higher in the paraplegia group than the tetraplegia group (24.44 +/- 4.23 vs 22.65 +/- 4.27, p = 0.01; 185.71 +/- 40.69 vs 163.28 +/- 37.92, p < 0.001; and 102.51 +/- 28.20 vs 89.15 +/- 22.35, p = 0.01, respectively). Patients with paraplegia may have increased hypertension, higher BMI, and increasing levels of serum LDL-C and TC than those with tetraplegia. Conventional risk factors for CHD should be identified and treated in individuals with SCI.
authors.affiliation: Brain and Spinal Injury Research (BASIR) Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Hadis
authors.initials: H
authors.lastname: Sabour
authors.forename: Abbas Norouzi
authors.initials: AN
authors.lastname: Javidan
authors.forename: Neda
authors.initials: N
authors.lastname: Ranjbarnovin
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Vafa
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khazaeipour
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Ghaderi
authors.forename: Fatemeh Khanzadeh
authors.initials: FK
authors.lastname: Mehrabani
authors.forename: Farzad
authors.initials: F
authors.lastname: Shidfar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007492:Iran / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000453:epidemiology; D010264:Paraplegia / Q000097:blood / Q000503:physiopathology*; D011782:Quadriplegia / Q000097:blood / Q000503:physiopathology*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013119:Spinal Cord Injuries / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides