title: Histone methyltransferase and histone methylation in inflammatory T-cell responses.
abstract: During immune responses, T cells require tightly controlled expression of transcriptional programs to regulate the balance between beneficial and harmful immunity. These transcriptional programs are critical for the lineage specification of effector T cells, the production of effector cytokines and molecules, and the development and maintenance of memory T cells. An emerging theme is that post-translational modification of histones by methylation plays an important role in orchestrating the expression of transcriptional programs in T cells. In this article, we provide a broad overview of histone methylation signatures for effector molecules and transcription factors in T cells, and the functional importance of histone methyltransferases in regulating T-cell immune responses.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5942, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: He
authors.forename: Qing
authors.initials: Q
authors.lastname: Tong
authors.forename: Dennis Keith
authors.initials: DK
authors.lastname: Bishop
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007156:Immunologic Memory / Q000502:physiology*; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase