title: [Clinical and therapeutic features in patients with common variable immunodeficiency from two third-level care hospitals from Mexico City].
abstract: BACKGROUND
  Common variable immunodeficiency (CVID) is one of the most common antibody deficiencies, is characterized by low serum immunoglobulins, defective antibody response and increased susceptibility to chronic and recurrent infections.
  
  
  OBJECTIVE
  we present the clinical findings of patients with CVID in two hospitals in Mexico City.
  
  
  METHODS
  We performed a retrospective study of patients who filled CVID criteria. We collected the following information, demographic data, age at onset, age at diagnosis, family history, infection, autoimmunity, lymphoproliferative disease, allergy, malignancy, immunoglobulin levels at diagnosis, route of administration, dosage and frequency of IVIG of each patient. Data were analyzed with descriptive statistics.
  
  
  RESULTS
  Amongst 26 patients who filled CVID criteria, 14 were men and 12 women. The mean diagnosis delay was 48 months (22-128), serum immunoglobulins at diagnosis in mg/dL were IgG 216 (114-316), IgM 21 (12-121), IgA 21 (6-26) and IgE 4.6 (1.8) IU/mL. 81% of patients suffered pneumonia. There was a decrease in the number of pneumonias before and after treatment with gammaglobulin (p = 0.028). 27% of the patients had autoimmune diseases, 35% allergies, 35% chronic diarrhea, 62% bronchiectasis, 73% chronic cough, 50% lymphadenopathy. One patient had lymphoproliferative disease and none developed malignancy.
  
  
  CONCLUSIONS
  We found that the delay in the diagnosis and initiation of gammaglobulin replacement affects the occurrence of complications such as bronchiectasis.
authors.affiliation: Unidad de InvestigaciÛn en Inmunodeficiencias, Instituto Nacional de PediatrÌa, MÈxico D.F.
authors.forename: Raul
authors.initials: R
authors.lastname: Dorbeker-Azcona
authors.forename: Marìa Dolores
authors.initials: MD
authors.lastname: Mogica-Martìnez
authors.forename: Martìn
authors.initials: M
authors.lastname: Becerril-Ngeles
authors.forename: Martha
authors.initials: M
authors.lastname: Guevara-Cruz
authors.forename: Sara
authors.initials: S
authors.lastname: Espinosa-Padilla
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Yamazaki-Nakashimada
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Blancas-Galicia
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014504:Urban Health