title: Successful use of maintenance infliximab for nephropathy in a patient with secondary amyloidosis complicating Crohn's disease.
abstract: Systemic AA amyloidosis is a complication of various inflammatory diseases including Crohn's disease (CD). Amyloid nephropathy is the most common clinical presentation of AA amyloidosis leading to renal failure, and affected patients often require hemodialysis and ultimately renal transplantation. We herein report the successful use of infliximab as maintenance therapy for amyloid nephropathy in a patient with CD. In the present patient, surgical treatment and infliximab infusion immediately induced a remission of CD, and scheduled infliximab therapy successfully maintained the patient's stable condition for three years, with a significant decrease in the serum creatinine level.
authors.affiliation: Department of Internal Medicine II, Shimane University, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tada
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ito
authors.forename: Kosuke
authors.initials: K
authors.lastname: Matsui
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sonoyama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Oka
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Kusunoki
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Fukuba
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mishima
authors.forename: Naoiki
authors.initials: N
authors.lastname: Oshima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Moriyama
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yuki
authors.forename: Kousaku
authors.initials: K
authors.lastname: Kawashima
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D007674:Kidney Diseases / Q000150:complications / Q000188:drug therapy*; D060046:Maintenance Chemotherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab