title: Short and medium-term outcomes of live-born twins after fetoscopic laser therapy for twin-twin transfusion syndrome.
abstract: OBJECTIVE
  To evaluate short and medium term outcomes of children born of monochorionic pregnancies complicated by twin-twin transfusion syndrome treated by fetoscopic laser surgery.
  
  
  METHODS
  This was a retrospective observational study performed between May 2007 and 2012. Neonatal data was from 45 patients under 5 years of age. The prospective observational study was of the neurologic outcome of these children using the Ages and Stages Questionnaire (ASQ), 2nd edition, French version, at up to 5 years of age.
  
  
  RESULTS
  Neurologic assessment at discharge from maternity unit was normal for 41 infants (93.2%). Logistic regression suggested that the risk of neurosensory sequelae was significantly related to the status of donor [odds ratio=4.62 (1.18; 18.0)] and significantly preterm birth <32 weeks of gestation [odds ratio=5.50 (1.38; 21.9)]. Eleven questionnaires were considered abnormal (31.1%). Two children presented a severe neurologic abnormality (5.7%). There was no significant correlation between any area of the questionnaire and status at birth (donor or recipient).
  
  
  CONCLUSIONS
  The data from our cohort, particularly as regards neurologic outcome, were satisfactory and concordant with previously published results. The use of the ASQ as a screening tool for neurologic outcome in children is original, which allowed in our cohort to highlight early neurological disorders.
authors.forename: Barthélémy
authors.initials: B
authors.lastname: Tosello
authors.forename: Julie
authors.initials: J
authors.lastname: Blanc
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Haumonté
authors.forename: Claude
authors.initials: C
authors.lastname: D'Ercole
authors.forename: Catherine
authors.initials: C
authors.lastname: Gire
mesh_terms: D000328:Adult; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005330:Fetofetal Transfusion / Q000150:complications / Q000601:surgery*; D005332:Fetoscopy / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000379:methods*; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome