title: [Analysis of the -238(G/A)TNF polymorphism in breast cancer patients].
abstract: TNF is an inflammatory cytokine that involved in pathogenesis of different malignancies. Promoter single nucleotide polymorphism -238(G/A)TNF (rs361525) is investigated for the detection of susceptibility to the infectious, autoimmune and oncological diseases. The goal of the study was to investigate the association of-238(G/A)TNF polymorphism (rs361525) with breast cancer (BC) prognosis. -238(G/A) TNF allelic variants were detected by PCR-RFLP. We failed to reveal the genotype distributions disparity among groups with different stages of the disease, ER, PR or Her2/neu positive versus negative status. The AG genotype frequency was about 10% and there were no BC patients with AA genotype in all separated groups. However the overall survival was significantly lower for AG then for GG carriers with II stage or ER-positive BC. Our data suggest that -238(G/A)TNF polymorphism perhaps is not involved in the initiation of malignancies but it is a substantial factor of BC prognosis.
authors.affiliation: Blokhin Russian Cancer Research Center, RAMS, Moscow, Russia
authors.forename: T F
authors.initials: TF
authors.lastname: Malivanova
authors.forename: E V
authors.initials: EV
authors.lastname: Skoromyslova
authors.forename: V A
authors.initials: VA
authors.lastname: Yurchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Kononenko
authors.forename: L V
authors.initials: LV
authors.lastname: Manzyuk
authors.forename: N N
authors.initials: NN
authors.lastname: Mazurenko
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic; D048069:Tumor Necrosis Factors / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D048069:Tumor Necrosis Factors