title: Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.
abstract: Liposarcoma is the second most common soft tissue sarcoma in adults, but treatment options have been quite limited thus far. In this study, we investigated the functional and therapeutic relevance of cyclin-dependent kinase 11 (CDK11) as a putative target in liposarcoma. CDK11 knockdown by synthetic siRNA or lentiviral shRNA decreased cell proliferation, and induced apoptosis in liposarcoma cells. Moreover, CDK11 knockdown enhances the cytotoxic effect of doxorubicin to inhibit cell growth in liposarcoma cells. These findings suggest that CDK11 is critical for the growth and proliferation of liposarcoma cells. CDK11 may be a promising therapeutic target for the treatment of liposarcoma patients.
authors.affiliation: Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Pharmacology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jia
authors.forename: Edwin
authors.initials: E
authors.lastname: Choy
authors.forename: Gregory
authors.initials: G
authors.lastname: Cote
authors.forename: David
authors.initials: D
authors.lastname: Harmon
authors.forename: Shunan
authors.initials: S
authors.lastname: Ye
authors.forename: Quancheng
authors.initials: Q
authors.lastname: Kan
authors.forename: Henry
authors.initials: H
authors.lastname: Mankin
authors.forename: Francis
authors.initials: F
authors.lastname: Hornicek
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Duan
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D008067:Lipoma / Q000201:enzymology; D008080:Liposarcoma / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D034741:RNA, Small Interfering / Q000235:genetics; D046888:Tissue Array Analysis
chemical_list: D000903:Antibiotics, Antineoplastic; D034741:RNA, Small Interfering; D004317:Doxorubicin; C447612:CDK11a protein, human; D018844:Cyclin-Dependent Kinases
keywords: CDK11; Immunohistochemistry; Kinase; Liposarcoma; Tissue microarray