title: [Correlation of gene polymorphism and risk of aggressive periodontal disease].
abstract: The study included 179 patients aged 18-45 years (56 with aggressive periodontal disease and 123 with no clinical signs of periodontitis). Gene polymorphism was analyzed by means of real-time PCR and kissing probes in order to reveal marker panel for aggressive periodontal disease predisposition. Significant difference was found for gene MMP9 in rs17576 position for A allele (55.2% in aggressive periodontal disease patients and 69.5% in control group) and in rs3918242 position for C allele (67.7 and 81.7%, respectively).
authors.forename: O A
authors.initials: OA
authors.lastname: Zorina
authors.forename: O A
authors.initials: OA
authors.lastname: Boriskina
authors.forename: D V
authors.initials: DV
authors.lastname: Rebrikov
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000453:epidemiology* / Q000235:genetics*; D000483:Alleles; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D060888:Real-Time Polymerase Chain Reaction; D012306:Risk; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9