title: [A missense SNP in the codon of ADD1 phosphorylation site associated with non-cardia gastric cancer susceptibility in a Chinese population].
abstract: OBJECTIVE
  This study investigated the association between a missense SNP in the codon of ADD1 phosphorylation site and the susceptibility of non-cardia gastric cancer in a Chinese population.
  
  
  METHODS
  PhosphoSitePlus and dbSNP database were combined to discover missense SNPs in the codon of phosphorylation site. Then, we genotyped the missense SNP in 1, 998 cases with non-cardia gastric cancer and 2, 008 cancer-free controls of Chinese descent. Analysis was conducted by using Logistic model adjusted by gender and age.
  
  
  RESULTS
  The rs4963 in the codon of ADD1 phosphorylation site was found. The frequencies of the 3 rs4963 genotypes, CC, CG, GG, among controls were 25.2%, 50.4%, and 24.4%, respectively, among patients were 20.1%, 50.6%, and 29.3%, respectively. Compared with CC genotype, the rs4963 CG genotype and GG genotype significantly increased the risk of non-cardia gastric cancer with the odds ratios being 1.24 (95%CI: 1.06 ∼ 1.46, P = 0.008) and 1.49 (95%CI: 1.25 ∼ 1.78, P < 0.001), respectively.
  
  
  CONCLUSIONS
  Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer.
authors.affiliation: Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Meng-han
authors.initials: MH
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.forename: Dian-ke
authors.initials: DK
authors.lastname: Yu
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D003062:Codon; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D016017:Odds Ratio; D010766:Phosphorylation; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D003062:Codon; D000099291:Adducins