title: Regioselective and stereoselective entry to β,β-disubstituted vinyl ethers via the sequential hydroboration/Suzuki-Miyaura coupling of ynol ethers.
abstract: A highly regio- and stereoselective synthesis of stereodefined β,β-disubstituted alkenyl ethers featuring the sequential hydroboration/Suzuki-Miyaura coupling of ynol ethers has been described. A number of functional groups, including OMe, Ac, CO2Et, CN, halides, and alkyl, (hetero)aryl, and alkenyl groups, are well-tolerated under the reaction conditions. Furthermore, it allows a facile entry to the labile diarylacetaldehydes by TFA-mediated hydrolysis of β,β-disubstituted vinyl ethers.
authors.affiliation: Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Cui
authors.forename: Mengyi
authors.initials: M
authors.lastname: Mao
authors.forename: Zuying
authors.initials: Z
authors.lastname: He
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu