title: Default network connectivity as a vulnerability marker for obsessive compulsive disorder.
abstract: BACKGROUND
  Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown.
  
  
  METHODS
  Here, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population.
  
  
  RESULTS
  Compared with healthy controls, OCD patients exhibited reduced strength of default network functional connectivity with the posterior cingulate cortex (PCC), and increased functional connectivity in the right inferior frontal lobe, insula, superior parietal cortex and superior temporal cortex, while their unaffected first-degree siblings only showed reduced local connectivity in the PCC.
  
  
  CONCLUSIONS
  These findings suggest that the disruptions of default network functional connectivity might be associated with family history of OCD. The decreased default network connectivity in both OCD patients and their unaffected siblings may serve as a potential marker of OCD.
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Peng
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: T
authors.initials: T
authors.lastname: Xu
authors.affiliation: Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China.
authors.forename: Q H
authors.initials: QH
authors.lastname: He
authors.affiliation: Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China.
authors.forename: C Z
authors.initials: CZ
authors.lastname: Shi
authors.affiliation: Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Guangzhou Psychiatry Hospital, Guangzhou, People's Republic of China.
authors.forename: G D
authors.initials: GD
authors.lastname: Miao
authors.affiliation: Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Jing
authors.affiliation: Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
authors.forename: K O
authors.initials: KO
authors.lastname: Lim
authors.affiliation: Key Laboratory of Behavioral Science, Laboratory for Functional Connectome and Development, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: X N
authors.initials: XN
authors.lastname: Zuo
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: R C K
authors.initials: RC
authors.lastname: Chan
mesh_terms: D000328:Adult; D015415:Biomarkers; D002540:Cerebral Cortex / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000503:physiopathology*; D035781:Siblings
chemical_list: D015415:Biomarkers