title: Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium.
abstract: Despite the numerous hurdles that gene therapy has encountered along the way, clinical trials over the last few years are showing promising results in many fields of medicine, including cardiology, where many targets are moving toward clinical development. In this review, the authors discuss the current state of the art in terms of clinical and preclinical development. They also examine vector technology and available vector-delivery strategies.
authors.affiliation: Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, 3500 N Broad St, MERB 941, Philadelphia, PA 19140, USA.
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Scimia
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cannavo
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Koch
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006331:Heart Diseases / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009206:Myocardium / Q000473:pathology