title: MicroRNA-mediated regulation in biological systems with oscillatory behavior.
abstract: As a class of small noncoding RNAs, microRNAs (miRNAs) regulate stability or translation of mRNA transcripts. Some reports bring new insights into possible roles of microRNAs in modulating cell cycle. In this paper, we focus on the mechanism and effectiveness of microRNA-mediated regulation in the cell cycle. We first describe two specific regulatory circuits that incorporate base-pairing microRNAs and show their fine-tuning roles in the modulation of periodic behavior. Furthermore, we analyze the effects of miR369-3 on the modulation of the cell cycle, confirming that miR369-3 plays a role in shortening the period of the cell cycle. These results are consistent with experimental observations.
authors.affiliation: Department of Mathematics, Shanghai University, Shanghai 200444, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Fengdan
authors.initials: F
authors.lastname: Xu
authors.forename: Zengrong
authors.initials: Z
authors.lastname: Liu
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Wang
authors.forename: Tieqiao
authors.initials: T
authors.lastname: Wen
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D035683:MicroRNAs