title: Swapping CENP-A at the centromere.
abstract: Faithful genome segregation depends on the functions of the eukaryotic centromere, which is characterized by the histone variant CENP-A. Gene replacement in human cells and fission yeast has now been used to show how CENP-A biochemically encodes centromere identity, as well as reveal an unexpected role for CENP-B in centromere function.
authors.affiliation: Department of Biochemistry, Stanford University Medical School, Stanford, California 94305-5307, USA.
authors.forename: Bradley T
authors.initials: BT
authors.lastname: French
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Straight
mesh_terms: D001324:Autoantigens / Q000235:genetics*; D002503:Centromere / Q000502:physiology*; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics*; D006801:Humans; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics*
chemical_list: D001324:Autoantigens; C000619700:CENPA protein, human; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D029702:Schizosaccharomyces pombe Proteins