title: Genotypic variation and outcomes in kidney transplantation: donor and recipient effects.
abstract: The genetic composition of a donor impacts long-term allograft survival after kidney transplantation. Effects of the recipient's genetic make-up, particularly variation in immune response pathway genes, are less certain. Bay et al. reveal improved graft survival in transplant recipients with lower copy numbers of the complement 4 gene (C4) after receipt of deceased-donor kidneys. Genomics breakthroughs in nephrology and immunology will likely revolutionize the field of transplant medicine.
authors.affiliation: Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157-1053, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Gautreaux
authors.forename: Barry I
authors.initials: BI
authors.lastname: Freedman
mesh_terms: D003181:Complement C4 / Q000235:genetics*; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D014019:Tissue Donors
chemical_list: D003181:Complement C4