title: Laevinoids A and B: two diterpenoids with an unprecedented backbone from Croton laevigatus.
abstract: Chemical fractionation of the ethanolic extract of a Chinese herbal plant, Croton laevigatus, yielded laevinoids A (1) and B (2) with a new rearranged ent-clerodane scaffold named as laevinane. The structures of 1 and 2 were assigned on the basis of detailed spectroscopic analyses with their absolute configurations being established via single-crystal X-ray diffraction studies.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; C586660:laevinoid A; C586661:laevinoid B; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1