title: Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics.
abstract: Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood-brain barrier allow great opportunity to design a "makeup" with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, A-1201, University of Louisville, 500 South Preston Street, Louisville, KY, 40202, USA.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Kalani
authors.forename: Alka
authors.initials: A
authors.lastname: Tyagi
authors.forename: Neetu
authors.initials: N
authors.lastname: Tyagi
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems / Q000639:trends; D055354:Exosomes / Q000378:metabolism*; D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D035683:MicroRNAs / Q000008:administration & dosage / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D018696:Neuroprotective Agents; D034741:RNA, Small Interfering