title: Breaking the canon: indirect regulation of Wnt signaling in mammary stem cells by MMP3.
abstract: Matrix metalloproteases promote tumor cell invasion, epithelial-to-mesenchymal transitions, and metastases, but whether they directly regulate stem cells is unknown. In this issue of Cell Stem Cell, Kessenbrock et al. (2013) now show that MMP3, independent of its proteolytic activity, regulates murine mammary stem cells by sequestering noncanonical Wnt signaling ligands, which has implications for breast cancer pathogenesis.
authors.affiliation: Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. malabarge@lbl.gov
authors.forename: Mark A
authors.initials: MA
authors.lastname: LaBarge
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D004848:Epithelium / Q000502:physiology*; D008321:Mammary Glands, Animal / Q000166:cytology*; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; C468567:Wnt5b protein, mouse; D019278:Matrix Metalloproteinase 3