title: Receptor trafficking hypothesis revisited: plasticity of AMPA receptors during established status epilepticus.
abstract: Status epilepticus (SE) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor (AMPAR)-mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR-mediated excitatory postsynaptic currents at Schaffer collateral - CA1 pyramidal neuron synapses during ESE. Surface expression of the GluA1 subunit increased, and this was a consequence of N-methyl-d-aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE. These studies suggest that AMPAR-mediated glutamatergic transmission is strengthened during ESE.
authors.affiliation: Department of Neurology, University of Virginia, Health Sciences Center, Charlottesville, VA, U.S.A.
authors.forename: Karthik
authors.initials: K
authors.lastname: Rajasekaran
authors.forename: Suchitra
authors.initials: S
authors.lastname: Joshi
authors.forename: Maxim
authors.initials: M
authors.lastname: Kozhemyakin
authors.forename: Marko S
authors.initials: MS
authors.lastname: Todorovic
authors.forename: Samuel
authors.initials: S
authors.lastname: Kowalski
authors.forename: Corinne
authors.initials: C
authors.lastname: Balint
authors.forename: Jaideep
authors.initials: J
authors.lastname: Kapur
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013226:Status Epilepticus / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate
keywords: AMPA receptor; CA1 pyramidal neurons; Glutamate; Plasticity; Receptor trafficking; Status epilepticus