title: [Determination pharmacokinetics parameters of raw and different processed epimediums by pharmacology effect method].
abstract: OBJECTIVE
  To determine the pharmacokinetics parameters of raw and different processed epimediums with pharmacology effect method.
  
  
  METHODS
  The kidney-yang deficiency model mice induced with hydrocortisone was used and oxidative stress level was taken as index to estimate main pharmacokinetics parameters of raw and different processed epimediums.
  
  
  RESULTS
  After raw and different processed epimediums po. in mice, the main pharmacokinetics parameters were: raw epimedium AUC(0-t) = 184.77 (g/kg) x h, AUC(0-infinity) = 342.30 (g/kg) x h, MRT(0-t) = 5.95 h, MRT (0-infinity) = 28.58 h,Tmax, = 0.75 h, Cmax = 57.67 g/kg; Fried epimedium AUC(0-t) = 208.08 (g/kg) x h, AUC(0-infinity) = 523.95 (g/kg) x h, MRT(0-t) = 5.86 h, MRT(0-infinity) = 22.55h, Tmax = 1 h, Cmax = 62.53 g/kg; Fat-fried epimedium AUC (0-t) = 232.17 (g/kg) x h, AUC(0-infinity) = 629.96 (g/kg) x h, MRT(0-t) = 5.28 h, MRT(0-infinity) = 19.62 h, Tmax = 1.5 h, Cmax = 81.84 g/kg.
  
  
  CONCLUSIONS
  The differences of Cmax and AUC between processed products and raw products are significant, and the sequence is as follows: fat-fried products > fried products > raw products.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. cuili2008516@126.com
authors.forename: Li
authors.initials: L
authors.lastname: Cui
authors.forename: E
authors.initials: E
authors.lastname: Sun
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Fan
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zou
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D034181:Epimedium / Q000737:chemistry*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D016711:Yang Deficiency / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde