title: A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models.
abstract: We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug concentration levels observed exiting the lobule with their detailed distribution inside the lobule, and indicate the role that structural variation has on these results. Liver zonation and its role on drug metabolism represent another aspect of structural inhomogeneity that we consider here. Since various liver diseases can be thought to produce such structural variations, our analysis gives insight into the role of disease on liver function and performance. These conclusions are based on the dominant role of convection in well-vascularized tissue with a given structure.
authors.affiliation: Department of Physics and Experimental Oncology, University of Alberta, Edmonton, AB T6G 2J1, Canada. jackt@ualberta.ca.
authors.forename: Vahid
authors.initials: V
authors.lastname: Rezania
authors.forename: Rebeccah
authors.initials: R
authors.lastname: Marsh
authors.forename: Dennis
authors.initials: D
authors.lastname: Coombe
authors.forename: Jack
authors.initials: J
authors.lastname: Tuszynski
mesh_terms: D001692:Biological Transport; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004058:Diffusion; D017709:Fractals; D006801:Humans; D008658:Inactivation, Metabolic; D007700:Kinetics; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D055442:Metabolome; D008954:Models, Biological; D017239:Paclitaxel / Q000378:metabolism / Q000493:pharmacokinetics; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012212:Rheology; D014867:Water
chemical_list: D004364:Pharmaceutical Preparations; D014867:Water; D003577:Cytochrome P-450 Enzyme System; D017239:Paclitaxel