title: Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices.
abstract: Amorphous solid dispersions (ASD) of curcumin (Cur) in cellulose derivative matrices, hydroxypropylmethylcellulose acetate succinate (HPMCAS), carboxymethylcellulose acetate butyrate (CMCAB), and cellulose acetate adipate propionate (CAAdP) were prepared in order to investigate the structure-property relationship and identify polymer properties necessary to effectively increase Cur aqueous solution concentration. XRD results indicated that all investigated solid dispersions were amorphous, even at a 9:1 Cur:polymer ratio. Both stability against crystallization and Cur solution concentration from these ASDs were significantly higher than those from physical mixtures and crystalline Cur. Remarkably, curcumin was also stabilized against chemical degradation in solution. Chemical stabilization was polymer-dependent, with stabilization in CAAdP>CMCAB>HPMCAS>PVP, while matrices enhanced solution concentration as PVP>HPMCAS>>CMCAB≈CAAdP. HPMCAS/Cur dispersions have useful combinations of pH-triggered release profile, chemical stabilization, and strong enhancement of Cur solution concentration.
authors.affiliation: Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Stephanie
authors.initials: S
authors.lastname: Konecke
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Wegiel
authors.forename: Lynne S
authors.initials: LS
authors.lastname: Taylor
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Edgar
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003460:Crystallization; D003474:Curcumin / Q000737:chemistry*; D004355:Drug Stability; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; C005062:acetylcellulose; D002482:Cellulose; D003474:Curcumin
keywords: Amorphous solid dispersion; Cellulose ester; Curcumin; Drug delivery; Solubility; Stability