title: Practicability of pharmacogenetics in transplantation medicine.
abstract: Implementation of pharmacogenetics in transplantation medicine has not met the expectations expressed 15 years ago. Numerous studies have reported associations between gene polymorphisms and pharmacokinetics of immunosuppressive drugs. Evidence that genotype-based dosing improves outcome is lacking. Extensive therapeutic drug monitoring (TDM) can rapidly correct for the variability in drug exposure caused by genetic differences. The contribution of genotype-based dosing will be more pronounced for drugs for which pharmacokinetic or pharmacodynamic monitoring is not applied.
authors.affiliation: 1] Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Gelder
authors.affiliation: Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: R H
authors.initials: RH
authors.lastname: van Schaik
authors.affiliation: Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: D A
authors.initials: DA
authors.lastname: Hesselink
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000235:genetics; D016903:Drug Monitoring; D005838:Genotype; D014453:Glucuronosyltransferase / Q000378:metabolism; D006084:Graft Rejection / Q000235:genetics* / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D016377:Organ Transplantation / Q000639:trends*; D010597:Pharmacogenetics / Q000639:trends*; D011110:Polymorphism, Genetic / Q000235:genetics; D000090264:UDP-Glucuronosyltransferase 1A9
chemical_list: D007166:Immunosuppressive Agents; C510164:CYP3A5 protein, human; D051544:Cytochrome P-450 CYP3A; D014453:Glucuronosyltransferase; D000090264:UDP-Glucuronosyltransferase 1A9