title: Accumulation of central fat correlates with an adverse oxidative balance in non-obese postmenopausal women.
abstract: The aim of the present study was to investigate whether accumulation of central fat is correlated with systemic oxidative stress (OxS) in non-obese apparently healthy postmenopausal women. Serum parameters of OxS (hydroperoxides and non-enzymatic antioxidants) along with body fat distribution, as assessed by dual-energy-X-ray absorptiometry (DXA), were evaluated in 134 non-obese postmenopausal women. Multiple regression analysis showed that central (trunk) fat significantly correlated with both markers of OxS independently of confounding factors (i.e. BMI, smoking, age, hypertension, legs and arms fat mass). In specific, the standardized regression coefficient was positive for hydroperoxides (β = 0.324, p < 0.05) and negative for antioxidants (β = -0.495, p < 0.01) level. In conclusion, the current data showed that the increase in central fat is an independent predictor of OxS condition among non-obese women in postmenopausal status. The possible pro-oxidant effects of the excess in central adiposity might be more harmful among post- than among pre-menopausal women, due to the postulated ability of E2 to contrast oxidative challenge and the related diseases.
authors.affiliation: Department of Biomedical and Specialist Surgical Sciences .
authors.forename: Carlo
authors.initials: C
authors.lastname: Cervellati
authors.forename: Gloria
authors.initials: G
authors.lastname: Bonaccorsi
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cremonini
authors.forename: Arianna
authors.initials: A
authors.lastname: Romani
authors.forename: Enrica
authors.initials: E
authors.lastname: Fila
authors.forename: Cristina
authors.initials: C
authors.lastname: Castaldini
authors.forename: Stefania
authors.initials: S
authors.lastname: Ferrazzini
authors.forename: Leo
authors.initials: L
authors.lastname: Massari
authors.forename: Monica
authors.initials: M
authors.lastname: Squerzanti
authors.forename: Claudia
authors.initials: C
authors.lastname: Sticozzi
authors.forename: Carlo
authors.initials: C
authors.lastname: Mischiati
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Bergamini
mesh_terms: D050153:Abdominal Fat; D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis; D001823:Body Composition; D050218:Body Fat Distribution; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000503:physiopathology*; D018384:Oxidative Stress; D017698:Postmenopause; D012044:Regression Analysis
chemical_list: D000975:Antioxidants; D006861:Hydrogen Peroxide