title: SDRIFE (baboon syndrome) due to paracetamol: case report.
abstract: The term "baboon syndrome" (BS) (recently known as symmetrical drug related intertriginous and flexural exanthema, SDRIFE) was introduced in 1984 to describe a specific skin eruption (resembling the red gluteal area of baboons) that occurred after systemic exposure to contact allergens. The crucial characteristics include a sharply defined symmetric erythema in the gluteal area and in the flexural or intertriginous folds without any systemic symptoms or signs. Because the term BS does not reflect the complete range of symptoms and is ethically problematic, it was replaced with a new term of SDRIFE. This term specifically refers to the distinctive clinical pattern of drug eruption induced by exposure to a systemically administered drug, presented as sharply demarcated symmetric erythematous areas of the gluteal/perianal area and/or V-shaped erythema of the inguinal/perigenital area (at least one other intertriginous/flexural localization) and absence of systemic symptoms and signs. We present a case of a 33-year-old man with SDRIFE due to Panadol® tablets (paracematol). On admission, there was a densely disseminated, symmetric, livid to erythematous maculopapular exanthema present in both axillae, the sides of the trunk, inguinally spreading towards the thighs, in cubital and popliteal fossae, on the back sides of the upper legs, and in the gluteal regions. Awareness of SDRIFE (BS) as an unusual drug reaction is especially important since the connection between skin eruption and drug exposure may easily be overlooked or misdiagnosed.
authors.affiliation: Department of Dermatovenereology, Sestre milosrdnice University Hospital Center. Vinogradska cesta 29. HR-10000 Zagreb, Croatia. liborija@gmail.com
authors.forename: Liborija
authors.initials: L
authors.lastname: Lugović-Mihić
authors.forename: Tomislav
authors.initials: T
authors.lastname: Duvančić
authors.forename: Majda
authors.initials: M
authors.lastname: Vučić
authors.forename: Mirna
authors.initials: M
authors.lastname: Situm
authors.forename: Maja
authors.initials: M
authors.lastname: Kolić
authors.forename: Josip
authors.initials: J
authors.lastname: Mihić
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D058633:Antipyretics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007868:Leg Dermatoses; D008297:Male; D013577:Syndrome
chemical_list: D058633:Antipyretics; D000082:Acetaminophen