title: Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease.
abstract: OBJECTIVE
  Diabetes mellitus and periodontitis are closely related. A huge number of reports has addressed the effect of periodontal intervention therapy on glycemic control, but no reports have addressed the effect of glycemic intervention therapy on periodontal disease in type 2 diabetic patients. The aim of this study was to examine the effect of improved glycemic control by glycemic intervention therapy on periodontitis in type 2 diabetic patients.
  
  
  METHODS
  A total of 35 patients underwent intervention therapy to improve glycemic control without periodontal treatment. Glycohemoglobin (HbA1c), high-sensitivity C-reactive protein (hs-CRP), bleeding on probing (BOP), probing pocket depth (PPD) and intraoral community periodontal index (CPI) codes of the World health Organization (WHO) were examined at baseline, and 2 and 6 months after the intervention therapy to improve glycemic control.
  
  
  RESULTS
  After the improvement of glycemic control, BOP lesions improved, but deep PPD lesions and WHO CPI codes did not improve. Subanalyses showed that effective glycemic control (average HbA1creduction 1.8%) improved BOP lesions, but did not affect deep PPD lesions and WHO CPI codes. In addition, high BOP lesions at baseline responded more effectively to glycemic intervention. Further analysis of CPI codes in all individual periodontal sites independent of WHO CPI codes in 35 patients showed that only gingival inflammation without a deep periodontal pocket improved after glycemic intervention.
  
  
  CONCLUSIONS
  Effective glycemic control improves BOP lesions in type 2 diabetic patients with periodontitis through ameliorating inflammation at the gingival sites of periodontal tissue. This trial was registered with the University Hospital Medical Information Network (no. UMIN000007670).
authors.affiliation: Department of Periodontology and the GCOE Program, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University Tokyo, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Katagiri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nitta
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
authors.forename: Masao
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuo
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Chiba
authors.forename: Michiaki
authors.initials: M
authors.lastname: Fukui
authors.forename: Naoto
authors.initials: N
authors.lastname: Nakamura
authors.forename: Fumishige
authors.initials: F
authors.lastname: Oseko
authors.forename: Narisato
authors.initials: N
authors.lastname: Kanamura
authors.forename: Koji
authors.initials: K
authors.lastname: Inagaki
authors.forename: Toshihide
authors.initials: T
authors.lastname: Noguchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Naruse
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Matsubara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyauchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ando
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hanada
authors.forename: Shuji
authors.initials: S
authors.lastname: Inoue
keywords: Bleeding on probing; Periodontitis; Type 2 diabetes intervention therapy