title: Adjunctive input to the nuclear thyroid hormone receptor from the cell surface receptor for the hormone.
abstract: At thyroid hormone response elements on specific genes, complexes of nuclear thyroid hormone receptors (TRs) and 3,5,3'-triiodo-L-thyronine (T(3)), coactivator or corepressor nucleoproteins, and histone acetylases or deacetylases mediate genomic effects of the hormone. Nongenomic effects of the hormone are those whose initiation does not primarily depend upon formation of the TR-T(3) complex. Among the nongenomic effects of thyroid hormone are a set of actions initiated at a cell surface receptor on integrin αvβ3 that are relevant to a) intracellular trafficking of proteins, including TRβ1, b) serine phosphorylation and acetylation of this nuclear receptor, c) assembly within the nucleus of complexes of coactivators and corepressor, and d) transcription of specific genes, including that for TRβ1. These actions initiated at αvβ3 are reviewed here and appear to be adjunctive to the genomic actions of the TR-T(3) complex.
authors.affiliation: 1 Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences , Albany, New York.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Davis
authors.forename: Hung-Yun
authors.initials: HY
authors.lastname: Lin
authors.forename: Heng-Yuan
authors.initials: HY
authors.lastname: Tang
authors.forename: Faith B
authors.initials: FB
authors.lastname: Davis
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones