title: Autophagy-dependent ATP release from dying cells via lysosomal exocytosis.
abstract: ATP not only represents a key molecule for the intracellular storage and utilization of energy, but also plays a central role in the extracellular milieu, as it both recruits and activates immune cells. The secretion of ATP in the course of immunogenic cell death (ICD), a peculiar type of apoptosis that elicits adaptive immune responses, critically relies on the molecular machinery for autophagy. We have recently demonstrated that autophagy allows for the ICD-associated secretion of ATP as it contributes to the maintenance of lysosomal ATP stores. In addition, we found that ATP release in this setting is mediated by a molecular mechanism that involves lysosomal-associated membrane protein 1 (LAMP1)- and pannexin 1 (PANX1)-dependent lysosomal exocytosis.
authors.affiliation: INSERM, U848; Villejuif, France; Gustave Roussy; Villejuif, France; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.
authors.forename: Yidan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: INSERM, U848; Villejuif, France; Gustave Roussy; Villejuif, France; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martins
authors.affiliation: INSERM, U848; Villejuif, France; Gustave Roussy; Villejuif, France; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ma
authors.affiliation: INSERM, U848; Villejuif, France; Gustave Roussy; Villejuif, France; Université Paris Sud/Paris XI; Le Kremlin Bicêtre, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.affiliation: Gustave Roussy; Villejuif, France; Université Paris Descartes/Paris V; Sorbonne Paris Cité; Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: INSERM, U848; Villejuif, France; Université Paris Descartes/Paris V; Sorbonne Paris Cité; Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Centre de Recherche des Cordeliers; Paris, France; Metabolomics and Cell Biology Platforms; Gustave Roussy; Villejuif, France; Pôle de Biologie; Hôpital Européen Georges Pompidou; Assistance Publique-Hôpitaux de Paris; Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D052118:Lysosomal-Associated Membrane Protein 1 / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism
chemical_list: D052118:Lysosomal-Associated Membrane Protein 1; D009419:Nerve Tissue Proteins; D000255:Adenosine Triphosphate
keywords: ATG5; ATG7; YO-PRO-1; caspase 3; immunogenic cell death; quinacrine