title: Effect of local extension sites on survival in locally advanced maxillary sinus cancer.
abstract: BACKGROUND
  We analyzed the effects of local extension sites on survival in patients with locally advanced maxillary sinus cancer.
  
  
  METHODS
  The criteria for inclusion in this study were as follows: (1) previously untreated maxillary sinus cancer; (2) squamous cell carcinoma; (3) T4 disease; and (4) curative-intent treatment. The data for 118 patients were obtained from 28 institutions across Japan and analyzed for overall survival and local control rates by local extension site.
  
  
  RESULTS
  Sites with a poor prognosis included the cribriform plate, dura, nasopharynx, middle cranial fossa, and cranial nerves other than V2. There was a significant correlation among these sites, except for the cranial nerves. Additionally, the hard palate was the only site that correlated with nodal involvement and showed a poor treatment outcome.
  
  
  CONCLUSIONS
  Even in cases presenting with similar T4 maxillary sinus cancer, treatment should be performed in consideration of the local extension site.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kano
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hayashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.forename: Kazuto
authors.initials: K
authors.lastname: Matsuura
authors.forename: Kengo
authors.initials: K
authors.lastname: Kato
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Nobuya
authors.initials: N
authors.lastname: Monden
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Onitsuka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Shigemichi
authors.initials: S
authors.lastname: Iwae
authors.forename: Kenji
authors.initials: K
authors.lastname: Okami
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuzuka
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Yoshino
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D016009:Chi-Square Distribution; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D008444:Maxillary Sinus Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: hard palate; local extension site; maxillary sinus cancer; radiation and intra-arterial cisplatin (RADPLAT); total maxillectomy