title: Association between OPCRIT dimensions and polymorphisms of HPA axis genes in bipolar disorder.
abstract: The aim of the study was to investigate the possible association between polymorphisms of HPA axis genes-CRHR1 (corticotrophin-releasing hormone receptor), NR3C1 (glucocorticoid receptor) and AVPR1B (arginine vasopressin receptor) and dimensions of bipolar disorder assessed by OPCRIT. We examined 560 patients with diagnosis of bipolar disorder (n=457) and unipolar disorder (n=103). Diagnosis was established by SCID and OPCRIT. We found association between polymorphisms of AVPR1b gene and psychotic dimension and CRHR1 polymorphisms and excitement and psychotic dimension. Our results suggest possible involvement of the AVPR1b and CRHR1 genes in the ethiology of psychotic features in the course of affective disorders, and possible involvement of CRHR1 gene in the ethiology of bipolar disorder.
authors.affiliation: Psychiatric Genetics Unit, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland. Electronic address: alrodziewicz@ump.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczyńska-Rodziewicz
authors.affiliation: Psychiatric Genetics Unit, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Maciukiewicz
authors.affiliation: Psychiatric Genetics Unit, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland; Laboratory of Molecular and Cell Biology, Department of Pulmonology, Pediatric Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szczepankiewicz
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pogłodziński
authors.affiliation: Psychiatric Genetics Unit, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D017483:Receptors, Vasopressin / Q000235:genetics
chemical_list: C497713:NR3C1 protein, human; D018019:Receptors, Corticotropin-Releasing Hormone; D011965:Receptors, Glucocorticoid; D017483:Receptors, Vasopressin
keywords: Bipolar disorder; Genes; HPA axis; OPCRIT dimension