title: Synthesis, in vitro evaluation and molecular modelling of naphthalimide analogue as anticancer agents.
abstract: A series of amine substituted naphthalimide analogue were synthesized and evaluated for in vitro anti-tumour activities against 60 tumour cell lines at a single dose concentration of 10 μM. These new analogue showed potential anticancer activities against various cancer cell lines. Compound 5d exhibited significant growth inhibition and was evaluated as 60 cell panel at five dose concentration levels. Compound 5d proved to be fivefold more active than standard antitumour drug 5-fluorouracil (5-FU) with MG-MID GI50 and TGI values of 5.05 and 38.71 respectively. ct-DNA binding studies of most active compound 5d revealed strong interacting properties. Molecular docking studies in the active binding site provided complementary theoretical support for the experimental biological data acquired.
authors.affiliation: School of Chemistry and Biochemistry, Thapar University, Patiala 147004, Punjab, India.
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Verma
authors.forename: Vijay
authors.initials: V
authors.lastname: Luxami
authors.forename: Kamaldeep
authors.initials: K
authors.lastname: Paul
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D053644:Naphthalimides
keywords: Anticancer activity; DNA intercalation; Molecular modelling; Naphthalimide analogue; Physicochemical parameters