title: Effect of the Mediterranean diet on plasma adipokine concentrations in men with metabolic syndrome.
abstract: OBJECTIVE
  While a Mediterranean dietary pattern (MedDiet) has been associated with favorable changes in several features of metabolic syndrome (MetS), its impact on plasma adipokine concentrations remains largely unknown. The objective of this study was to determine the impact of the MedDiet consumed under controlled feeding conditions, without (-WL) and with weight loss (+WL), on plasma adipokine concentrations in adult men with MetS (NCEP-ATP III).
  
  
  METHODS
  The diet of 26 men with MetS (age 24 to 62 yrs) was first standardized to a North American control diet for 5 weeks. Participants then consumed a pre-determined MedDiet for 5 weeks. Both diets were consumed under weight-maintaining isoenergetic feeding conditions. Participants then underwent a 20-week free-living caloric restriction period, after which they consumed the MedDiet again in weight stabilizing, isoenergetic feeding conditions.
  
  
  RESULTS
  Body weight was reduced by 10.2%±2.9% and waist circumference by 8.6±3.3 cm after the weight loss period and stabilization on MedDiet (P<0.001). MedDiet-WL had no impact on plasma concentrations of leptin, plasminogen activator inhibitor-1, resistin, visfatin, acylation stimulating protein and adiponectin. MedDiet+WL reduced plasma leptin concentrations (P<0.01) and increased plasma adiponectin concentrations (P<0.05) compared with the control diet and MedDiet-WL.
  
  
  CONCLUSIONS
  Data from this nutritionally controlled study suggest that short-term consumption of MedDiet has little effect on the concentrations of many adipokines in the absence of weight loss.
authors.affiliation: Institute of Nutrition and Functional Foods, Laval University, 2440, boul. Hochelaga, Québec (Qc), Canada, G1V 0A6.
authors.forename: Caroline
authors.initials: C
authors.lastname: Richard
authors.forename: Marie-Michelle
authors.initials: MM
authors.lastname: Royer
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
authors.forename: Reza
authors.initials: R
authors.lastname: Rezvani
authors.forename: Sophie
authors.initials: S
authors.lastname: Desroches
authors.forename: Benoît
authors.initials: B
authors.lastname: Lamarche
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D031204:Caloric Restriction; D002784:Cholesterol / Q000097:blood; D038441:Diet, Mediterranean; D002149:Energy Intake; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol
keywords: ASP; Adipokines; Adiponectin; C; C-reactive protein; CRP; CVD; HDL-C; HMW; High Density Lipoprotein-cholesterol; IL; LDL-C; Low Density Lipoprotein–cholesterol; MUFA; MedDiet; Mediterranean diet; MetS; Metabolic syndrome; PUFA; SFA; TFA; TG; TNF-α; Weight loss; acylation stimulating protein; cardiovascular disease; cholesterol; high molecular weight; interleukin; metabolic syndrome; monounsaturated fatty acids; polyunsaturated fatty acids; saturated fatty acids; trans fatty acids; triglyceride; tumor necrosis factor-α