title: Effects of a sustained-release form of isosorbide dinitrate on left atrial pressure in dogs with experimentally induced mitral valve regurgitation.
abstract: BACKGROUND
  The effects of isosorbide dinitrate (ISDN) have not been sufficiently investigated in conscious dogs with mitral valve regurgitation (MR).
  
  
  OBJECTIVE
  The objective was to investigate the effects of a sustained-release form of ISDN (sr-ISDN) on hemodynamics and the autonomic nervous system in dogs with MR.
  
  
  METHODS
  Six healthy Beagles weighing 11.2 ± 2.2 kg (2 years of age; 2 males and 4 females) were used.
  
  
  METHODS
  Experimental, crossover, and interventional study. Dogs with experimentally induced MR were administered placebo, 2, 5, and 10 mg/kg sr-ISDN PO on separate days with a 7-day washout period between randomized dosings. Left atrial pressure (LAP) had been recorded continuously from 30 minutes before administration of sr-ISDN to 12 hours after administration.
  
  
  RESULTS
  LAP was significantly decreased after administration in the 5 and 10 mg/kg groups. Significant decrease was observed at 3 and 4 hours after administration in the 5 mg/kg group. In the 10 mg/kg group, significant decrease was observed at 2, 3, 4, 5, 6, 7, 10, and 11 hours after administration. The lowest value was observed at 4 hours after administration in the 5 and 10 mg/kg groups (20.9 ± 4.2 to 15.9 ± 3.9 mmHg, P < .01, and 21.3 ± 4.0 to 13.6 ± 4.2 mmHg, P < .001).
  
  
  CONCLUSIONS
  Sustained-release form of ISDN showed significant decrease of LAP in the 5 mg/kg and 10 mg/kg groups, and duration of effect was dose related.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: L
authors.initials: L
authors.lastname: Hamabe
authors.forename: D
authors.initials: D
authors.lastname: Aytemiz
authors.forename: H
authors.initials: H
authors.lastname: Huai-Che
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Yoshiyuki
authors.forename: T
authors.initials: T
authors.lastname: Fukayama
authors.forename: R
authors.initials: R
authors.lastname: Fukushima
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D062185:Atrial Pressure / Q000187:drug effects; D001794:Blood Pressure / Q000502:physiology; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D006339:Heart Rate / Q000502:physiology; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008944:Mitral Valve Insufficiency / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011897:Random Allocation; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate
keywords: Holter monitoring; Nitrates; Radiotelemetry; Vasodilator