title: Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats.
abstract: OBJECTIVE
  Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress.
  
  
  METHODS
  The male rats were treated with hesperetin in combination with lead acetate (500 mg/L).
  
  
  RESULTS
  The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control.
  
  
  CONCLUSIONS
  It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats.
authors.affiliation: Department of Veterinary Medicine, College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang, PR China.
authors.forename: Jicang
authors.initials: J
authors.lastname: Wang
authors.forename: Huali
authors.initials: H
authors.lastname: Zhu
authors.forename: Zijun
authors.initials: Z
authors.lastname: Yang
authors.forename: Zongping
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002374:Catalase / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006569:Hesperidin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009942:Organometallic Compounds; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009942:Organometallic Compounds; D014527:Uric Acid; D014508:Urea; D003404:Creatinine; D006569:Hesperidin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; C013015:hesperetin; C008261:lead acetate
keywords: Antioxidants; hesperetin; lead; oxidative stress; rats