title: Infernal 1.1: 100-fold faster RNA homology searches.
abstract: CONCLUSIONS
  Infernal builds probabilistic profiles of the sequence and secondary structure of an RNA family called covariance models (CMs) from structurally annotated multiple sequence alignments given as input. Infernal uses CMs to search for new family members in sequence databases and to create potentially large multiple sequence alignments. Version 1.1 of Infernal introduces a new filter pipeline for RNA homology search based on accelerated profile hidden Markov model (HMM) methods and HMM-banded CM alignment methods. This enables ∼100-fold acceleration over the previous version and ∼10 000-fold acceleration over exhaustive non-filtered CM searches.
  
  
  BACKGROUND
  Source code, documentation and the benchmark are downloadable from http://infernal.janelia.org. Infernal is freely licensed under the GNU GPLv3 and should be portable to any POSIX-compliant operating system, including Linux and Mac OS/X. Documentation includes a user's guide with a tutorial, a discussion of file formats and user options and additional details on methods implemented in the software.
  
  
  BACKGROUND
  nawrockie@janelia.hhmi.org
authors.affiliation: HHMI Janelia Farm Research Campus, Ashburn, VA 20147, USA.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Nawrocki
authors.forename: Sean R
authors.initials: SR
authors.lastname: Eddy
mesh_terms: D000465:Algorithms; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D017423:Sequence Analysis, RNA; D012689:Sequence Homology, Nucleic Acid; D012984:Software
chemical_list: D012313:RNA