title: [Tissue engineered skin and regenerative wound repair].
abstract: Various skin defects resulting from mechanical injury, burns, chronic ulcers, and resection of tumor etc. are very common in clinic. The traditional treatment measure, such as grafting of autologous split-thickness skin remains the gold standard. However, its limitations are obvious, such as shortage of donor sites, creation of new injury, and scar formation. To realize regenerative or scarless repair of tissue defects has always been the dream of human being. The advent of tissue engineered skin (TES) provides an ideal access to tissue regeneration. After decades of development, several kinds of TES products have been developed and used in clinic, with promising effects. However, a large number of basic scientific problems regarding TES, as well as difficulties in translation of basic research to bedside should be taken into serious consideration. This article presents a comprehensive overview of strategies of construction of TES, the role of TES in regenerative wound repair, and its opportunities and challenges.
authors.affiliation: Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
authors.forename: Chun-mao
authors.initials: CM
authors.lastname: Han
authors.forename: Xin-gang
authors.initials: XG
authors.lastname: Wang
mesh_terms: D006801:Humans; D044968:Regenerative Medicine; D012867:Skin / Q000293:injuries; D017768:Skin, Artificial; D023822:Tissue Engineering; D014945:Wound Healing