title: Clinical and epidemiological survey and analysis of the first case of human infection with avian influenza A(H7N9) virus in Hangzhou, China.
abstract: To investigate and report on the clinical and epidemiological characteristics of the first case of human infection with avian influenza A(H7N9) virus in Hangzhou, China. A field epidemiological survey was used to study the first case in Hangzhou. The patient was a 39-year-old male chef with a history of exposure to a farm product market and to poultry prior to the onset of disease on 15 March 2013. He had diarrhea, chills, pyrexia, and intermittent cough with freshly red foamy bloody sputum early in his disease. His fever > 39 °C continued for a week with rapid progression. Computed tomography findings showed extensive bilateral consolidation, followed by multiorgan failure. The patient died on the morning of 27 March. His infection was eventually confirmed 1 week later on 3 April. Flu-like symptoms including fever and cough were found in 46 of his 138 close contacts. This was the first case of human infection with avian influenza A(H7N9) virus in Hangzhou. None of the close contacts had onset of the disease. The case patient's condition progressed rapidly. The source of infection might be his exposure to the farm product market, but the mode of exposure remains unclear.
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou City, 310021, Zhejiang Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Ding
authors.forename: Q-J
authors.initials: QJ
authors.lastname: Kao
authors.forename: X-H
authors.initials: XH
authors.lastname: Yang
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Wen
authors.forename: H-K
authors.initials: HK
authors.lastname: Lv
authors.forename: Z-P
authors.initials: ZP
authors.lastname: Chen
authors.forename: E-F
authors.initials: EF
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: J-C
authors.initials: JC
authors.lastname: Pan
authors.forename: X-Y
authors.initials: XY
authors.lastname: Pu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: F-J
authors.initials: FJ
authors.lastname: Wang
authors.forename: X-P
authors.initials: XP
authors.lastname: Xu
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D016358:Contact Tracing; D017809:Fatal Outcome; D006801:Humans; D017053:Infection Control; D064766:Influenza A Virus, H7N9 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D008297:Male; D013902:Radiography, Thoracic