title: Synthesis and evaluation of the cytotoxic activities of some isatin derivatives.
abstract: A series of isatin derivatives, 1-butyl-5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (3a-d), 6-butyl-chloro/fluoro-6H-indolo[2,3-b]quinoxalines (4a-h), and 5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (5a-h) were synthesized and characterized by using Fourier transform (FT)-IR, (1)H- and (13)C-NMR spectroscopy, mass spectrometric and elemental analysis. The substances were further subjected to in vitro cytotoxicity evaluation against HeLa, SK-BR-3, and MCF-7 cells. The results showed that quinoxalines 4d, 4e, and 4g; and indolin-2-one 5f display significant in vitro cytotoxic activities against HeLa cells and further the compound 4d has resulted in highest cytotoxicity in the entire series studied. In addition, 5f was shown to display substantial activity against all the three cell lines used in the current study.
authors.affiliation: Department of Chemistry, Pusan National University.
authors.forename: Sanapalli Subba
authors.initials: SS
authors.lastname: Reddy
authors.forename: Ramjee
authors.initials: R
authors.lastname: Pallela
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Kim
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Won
authors.forename: Yoon-Bo
authors.initials: YB
authors.lastname: Shim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007510:Isatin; D004247:DNA