title: Changes of leptin concentration in plasma in patients with spinal cord injury: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis.
  
  
  METHODS
  Systematic Review.
  
  
  METHODS
  Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0.
  
  
  RESULTS
  The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (P<0.0001). The effect of spinal lesion level on plasma leptin concentration was also statistically significant (P<0.0001). Body mass index was positively related to plasma leptin concentration in both groups (P<0.0001).
  
  
  CONCLUSIONS
  This Meta analysis approves increased level of leptin in spinal cord injured patients which can be due to fat distribution changes and sympathetic dysfunction in these patients. Our results also showed that patients with higher spinal lesion level have higher plasma leptin concentration.
authors.affiliation: Brain and Spinal Injury Research center (BASIR), Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Latifi
authors.forename: D
authors.initials: D
authors.lastname: Koushki
authors.forename: A
authors.initials: A
authors.lastname: Norouzi Javidan
authors.forename: M
authors.initials: M
authors.lastname: Matin
authors.forename: H
authors.initials: H
authors.lastname: Sabour
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D004620:Embolism, Fat / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood*; D011237:Predictive Value of Tests; D013119:Spinal Cord Injuries / Q000097:blood* / Q000473:pathology*
chemical_list: D015415:Biomarkers; D020738:Leptin