title: A solitary mixed squamous cell and glandular papilloma of the lung.
abstract: Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is exceedingly rare, with only 18 cases reported in the literature. Herein, we report a case of mixed papilloma and its associated immunohistochemical and positron emission tomographic (PET) findings. A 60-year-old Japanese male with a smoking history of 40 pack-years presented with a smooth-edged pulmonary lesion in the right S5 segment on computed tomography (CT). F18-fluorodeoxyglucose (FDG) PET revealed abnormally increased FDG uptake in the mass (maximum standardized uptake value, 3.4). We performed right middle lobectomy and combined partial resection of the S8 segment. The 1.8-cm tumor that filled the enlarged lumen of the B5b was histologically diagnosed as mixed papilloma. Immunohistochemically, the pseudostratified columnar epithelium was positive for cytokeratin (CK) 5/6 and CK7. p40 positivity was predominant in the basal and squamous cells. Thyroid transcription factor-1 and carcinoembryonic antigen were negative on immunostaining. Malignant features were absent. The postoperative course has been uneventful for 3 months after the surgery. No recurrences were reported after the surgical resection of the mixed papilloma. Therefore, surgical resection may be considered the mainstay of curative treatment.
authors.affiliation: Division of Thoracic Surgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kozu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maniwa
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Ohde
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018307:Neoplasms, Squamous Cell / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010212:Papilloma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011013:Pneumonectomy; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18