title: Primary large B-cell lymphoma of the fourth ventricle.
abstract: We present a patient with an isolated primary central nervous system lymphoma (PCNSL) of the fourth ventricle. A 77-year-old man had a 1 week history of intermittent vertigo, nausea, vomiting, and progressively unsteady gait. CT scans of the brain showed a fourth ventricle tumor. MRI revealed a 2.5 cm dumbbell-shaped avidly-enhancing tumor in the fourth ventricle. Metastasis or high-grade glioma was suspected. The neuropathological findings were compatible with a diffuse large B-cell lymphoma. A slit lamp examination, bone marrow biopsy, and imaging studies for extracranial lesions were unremarkable. We suggest that PCNSL be listed in the differential diagnosis of fourth ventricle tumors with well-circumscribed margins and homogenous contrast enhancement.
authors.affiliation: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, ROC.
authors.forename: Chih-Hsiang
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; National Yang Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Lin
authors.affiliation: Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; National Yang Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Sheng-Che
authors.initials: SC
authors.lastname: Hung
authors.affiliation: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, ROC; National Yang Ming University School of Medicine, Taipei, Taiwan, ROC. Electronic address: doc3339b@gmail.com.
authors.forename: Sanford P C
authors.initials: SP
authors.lastname: Hsu
authors.affiliation: Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; National Yang Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Donald Ming-Tak
authors.initials: DM
authors.lastname: Ho
authors.affiliation: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112, Taiwan, ROC; National Yang Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Yang-Hsin
authors.initials: YH
authors.lastname: Shih
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D038524:Diffusion Magnetic Resonance Imaging; D020546:Fourth Ventricle / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000601:surgery; D008297:Male
keywords: Central nervous system; Diffuse large-cell lymphoma; Fourth ventricle tumor; Immunocompetence; Non-Hodgkin’s lymphoma