title: Antidepressant-like effect of novel 5-HT3 receptor antagonist N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p): an approach using rodent behavioral antidepressant tests.
abstract: OBJECTIVE
  The present study was designed to investigate the antidepressant potential of N-n-butyl-3-ethoxyquinoxalin-2-carboxamide (6p), a novel 5-HT3 receptor antagonist in rodent behavioral models of depression.
  
  
  METHODS
  The compound 6p was examined in various behavioral models like forced swim test (FST), tail suspension test (TST), mechanistic models [5-hydroxytryptophan (5-HTP)-induced head twitch and reserpine-induced hypothermia (RIH)], and in chronic surgery model-olfactory bulbectomy in rats.
  
  
  RESULTS
  Compound 6p (1, 2, and 4 mg/kg, i.p.) exhibited antidepressant-like effect in FST and TST after acute treatment without having an effect on baseline locomotor activity. Moreover, 6p (2 mg/kg, i.p.), potentiated the 5-HTP-induced head twitch responses in mice and inhibited the RIH in rats. Chronic treatment (14 days) with 6p (1 and 2 mg/kg, p.o.) and paroxetine (10 mg/kg, p.o.) in rats significantly reversed the behavioral anomalies induced by bilateral olfactory bulbectomy using open field exploration.
  
  
  CONCLUSIONS
  The preliminary studies reveal that compound 6p exhibits antidepressant-like effect in behavioral rodent models of depression.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
authors.forename: Shvetank
authors.initials: S
authors.lastname: Bhatt
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Mahesh
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Devadoss
authors.forename: Ankur Kumar
authors.initials: AK
authors.lastname: Jindal
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature; D005106:Exploratory Behavior / Q000187:drug effects; D006168:Guinea Pigs; D019417:Hindlimb Suspension; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000601:surgery; D011810:Quinoxalines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000494:pharmacology*; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D011810:Quinoxalines; D058831:Serotonin 5-HT3 Receptor Antagonists
keywords: 5-HT3 receptor antagonists; antidepressant; forced swim test; quinoxaline; serotonin