title: The regulation of iron metabolism in the mononuclear phagocyte system.
abstract: The daily iron absorption and loss are small and iron metabolism in human is characterized by a limited external exchange and by an efficient reutilization of iron from internal sources. The mononuclear phagocyte system (MPS) plays a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes, which is important in maintaining iron homeostasis. Many iron-related proteins are expressed in the MPS, including heme oxygenase (HO) for heme degradation, the iron importer transferrin receptor 1 (TfR1) and divalent metal transport 1 (DMT1), the iron exporter ferroportin 1 (FPN1) and the iron regulatory hormone hepcidin. Insights into the regulatory mechanisms that control the regulation of iron metabolism proteins in the MPS will deepen our understanding about the molecular mechanism of iron homeostasis and iron-related diseases.
authors.affiliation: Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, P. R. China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Kong
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Lei
authors.forename: Yan-Zhong
authors.initials: YZ
authors.lastname: Chang
mesh_terms: D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D027682:Cation Transport Proteins; D007501:Iron; D011990:Receptors, Transferrin; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2