title: Hormonal responses and test meal intake among obese teenagers before and after laparoscopic adjustable gastric banding.
abstract: BACKGROUND
  Relatively little is known about changes in eating behavior or hormonal responses to food after bariatric surgery in adolescents.
  
  
  OBJECTIVE
  This study compared eating behavior and hormones among adolescents in a bariatric surgery program with those in nonoverweight control adolescents and evaluated changes before and after laparoscopic adjustable gastric banding (LAGB).
  
  
  METHODS
  Fasting leptin, peptide YY (PYY), and ghrelin concentrations were obtained, and postprandial ghrelin and PYY area under the curve (AUC) were assessed after a single-item breakfast. Intake from an ad libitum lunchtime multi-item meal was measured.
  
  
  RESULTS
  Compared with controls (n = 9), all presurgical candidates (n = 20) had significantly greater fasting leptin, lower fasting ghrelin, and lower AUC ghrelin but similar PYY and AUC PYY. Preoperative candidates did not differ from controls in total energy consumed during the test meal. Postoperatively, among the 11 participants with data both before and after surgery, BMI (in kg/m(2)) decreased by 3.5 (P < 0.001), significantly less energy was consumed in the test meal, and a smaller number of foods were selected. AUC ghrelin and PYY did not significantly change before or after LAGB.
  
  
  CONCLUSIONS
  Few significant short-term changes were observed in appetitive hormones after LAGB. It is unclear whether objective measures of eating behavior will prove useful in evaluating the impact of bariatric surgery on outcomes. This trial was registered at clinicaltrials.gov as CT00764127.
authors.affiliation: Columbia Center for Eating Disorders, Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY (RS, MJD, JS, EZ, BTW); the Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY (RS, MJD, JS, EZ, BTW); the Department of Medical and Clinical Psychology, Uniformed Services University of Health Sciences, Bethesda, MD (MT-K); the Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (MT-K and JAY); the Department of Medicine, Columbia University, New York, NY (JK); and the Center for Adolescent Bariatric Surgery, Department of Surgery, Division of Pediatric Surgery, Columbia University Medical Center, New York, NY (JLZ).
authors.forename: Robyn
authors.initials: R
authors.lastname: Sysko
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Devlin
authors.forename: Janet
authors.initials: J
authors.lastname: Schebendach
authors.forename: Marian
authors.initials: M
authors.lastname: Tanofsky-Kraff
authors.forename: Ellen
authors.initials: E
authors.lastname: Zimmerli
authors.forename: Judith
authors.initials: J
authors.lastname: Korner
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Zitsman
authors.forename: B Timothy
authors.initials: BT
authors.lastname: Walsh
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D050110:Bariatric Surgery; D016022:Case-Control Studies; D005215:Fasting; D005247:Feeding Behavior; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D010535:Laparoscopy; D020738:Leptin / Q000097:blood; D008297:Male; D062407:Meals; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D019894:Peptide YY / Q000097:blood; D019518:Postprandial Period; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D054439:Ghrelin; D020738:Leptin; D019894:Peptide YY