title: Inflammatory myofibroblastic tumors in childhood.
abstract: Inflammatory myofibroblastic tumor (IMT) is a rare tumor of intermediate malignant potential that can occur anywhere in the body. Surgical resection is the principal treatment. We report on nine children diagnosed with IMT at our institution over a 10-year period. Presenting symptoms were reflective of tumor location. Complete surgical resection was curative. Local recurrence occurred in the presence of involved surgical margins. One patient with metastatic disease achieved long-term remission with chemotherapy alone. Severe inflammatory response and death occurred in one patient. The 3-year event free and overall survivals (OS) were 58 ± 20% and 89 ± 10% respectively.
authors.affiliation: 1Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, California, USA.
authors.forename: Bhakti
authors.initials: B
authors.lastname: Mehta
authors.forename: Leo
authors.initials: L
authors.lastname: Mascarenhas
authors.forename: Shengmei
authors.initials: S
authors.lastname: Zhou
authors.forename: Larry
authors.initials: L
authors.lastname: Wang
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000401:mortality* / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate