title: Slide to the left and slide to the right: motor coordination in neurons.
abstract: Molecular motors employ specific adaptor proteins to dock on transport cargos. Reporting in The Journal of Cell Biology, Fu and Holzbaur (2013) show that the adaptor JNK interacting protein 1 (JIP1) binds kinesin-1 and dynactin and controls bidirectional axonal amyloid precursor protein trafficking, suggesting a regulatory role for adaptors during cargo transport.
authors.affiliation: Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Martin
authors.initials: M
authors.lastname: Harterink
authors.forename: Casper C
authors.initials: CC
authors.lastname: Hoogenraad
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001370:Axonal Transport; D004398:Dyneins / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016564:Amyloid beta-Protein Precursor; D004398:Dyneins; D016547:Kinesins