title: Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography.
abstract: Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors. A comprehensive review of potential cardiac complications related to radiotherapy is warranted. An evidence-based review of several imaging approaches used to detect, evaluate, and monitor RIHD is discussed. Recommendations for the early identification and monitoring of cardiovascular complications of radiotherapy by cardiac imaging are also proposed.
authors.affiliation: Department of Cardiology, GIGA Cardiovascular Sciences, Heart Valve Clinic, University of Liège Hospital, CHU du Sart-Tilman, Liège 4000, Belgium. plancellotti@chu.ulg.ac.be
authors.forename: Patrizio
authors.initials: P
authors.lastname: Lancellotti
authors.forename: Vuyisile T
authors.initials: VT
authors.lastname: Nkomo
authors.forename: Luigi P
authors.initials: LP
authors.lastname: Badano
authors.forename: Jutta
authors.initials: J
authors.lastname: Bergler-Klein
authors.forename: Jutta
authors.initials: J
authors.lastname: Bergler
authors.forename: Jan
authors.initials: J
authors.lastname: Bogaert
authors.forename: Laurent
authors.initials: L
authors.lastname: Davin
authors.forename: Bernard
authors.initials: B
authors.lastname: Cosyns
authors.forename: Philippe
authors.initials: P
authors.lastname: Coucke
authors.forename: Raluca
authors.initials: R
authors.lastname: Dulgheru
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.forename: Oliver
authors.initials: O
authors.lastname: Gaemperli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Galderisi
authors.forename: Brian
authors.initials: B
authors.lastname: Griffin
authors.forename: Paul A
authors.initials: PA
authors.lastname: Heidenreich
authors.forename: Koen
authors.initials: K
authors.lastname: Nieman
authors.forename: Juan C
authors.initials: JC
authors.lastname: Plana
authors.forename: Steven C
authors.initials: SC
authors.lastname: Port
authors.forename: Marielle
authors.initials: M
authors.lastname: Scherrer-Crosbie
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Schwartz
authors.forename: Igal A
authors.initials: IA
authors.lastname: Sebag
authors.forename: Jens-Uwe
authors.initials: JU
authors.lastname: Voigt
authors.forename: Samuel
authors.initials: S
authors.lastname: Wann
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000328:Adult; D004307:Dose-Response Relationship, Radiation; D004452:Echocardiography / Q000379:methods / Q000592:standards*; D006321:Heart / Q000528:radiation effects*; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods / Q000592:standards*; D009369:Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000175:diagnosis* / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012306:Risk
keywords: Cardiac computed tomography; Cardiac magnetic resonance; Echocardiography; Heart disease; Nuclear cardiology; Radiotherapy