title: Neuropeptide downregulation in sepsis.
abstract: Neuropeptides are an extremely conserved arm of neurobiology. Despite their effects as neurohormones and neurotransmitters, a multitude of other effects have been described, putting in evidence their importance as regulators of immune responses, such as chemotaxis, oxidative burst, pro-inflammatory signaling, and many others. The effects of neuropeptides in the pathophysiology of sepsis, however, remain poorly investigated. A prospective cohort study to investigate the effects of neuropeptides in sepsis was carried out. Here, we describe that neuropeptides are downregulated during septic shock. We propose that it may be a protective mechanism of the host to avoid further inflammatory injury.
authors.affiliation: Emergency Medicine Department, University of São Paulo, São Paulo, Brazil, pinheirofabiano@hotmail.com.
authors.forename: Fabiano Pinheiro
authors.initials: FP
authors.lastname: da Silva
authors.forename: Marcel Cerqueira César
authors.initials: MC
authors.lastname: Machado
authors.forename: Paulo Clemente
authors.initials: PC
authors.lastname: Sallet
authors.forename: Fernando Godinho
authors.initials: FG
authors.lastname: Zampieri
authors.forename: Alessandra Carvalho
authors.initials: AC
authors.lastname: Goulart
authors.forename: Francisco
authors.initials: F
authors.lastname: Torggler Filho
authors.forename: Hermes Vieira
authors.initials: HV
authors.lastname: Barbeiro
authors.forename: Irineu Tadeu
authors.initials: IT
authors.lastname: Velasco
authors.forename: Luiz Monteiro
authors.initials: LM
authors.lastname: da Cruz Neto
authors.forename: Heraldo Possolo
authors.initials: HP
authors.lastname: de Souza
mesh_terms: D015331:Cohort Studies; D015536:Down-Regulation; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007249:Inflammation / Q000503:physiopathology*; D008550:Melatonin / Q000097:blood; D009479:Neuropeptides / Q000096:biosynthesis*; D009496:Neurotensin / Q000097:blood; D010121:Oxytocin / Q000097:blood; D011446:Prospective Studies; D012772:Shock, Septic / Q000503:physiopathology*; D013373:Substance P / Q000097:blood; D000521:alpha-MSH / Q000097:blood
chemical_list: D009479:Neuropeptides; D013373:Substance P; D009496:Neurotensin; D010121:Oxytocin; D000521:alpha-MSH; D008550:Melatonin; D006854:Hydrocortisone