title: [Efficacy and tolerability of controlled-release oxycodone against nab-paclitaxel-induced musculoskeletal pain in breast cancer patients].
abstract: Paclitaxel therapy often causes musculoskeletal pain, and some clinical studies have indicated that this pain is due to nerve injury, rather than muscle or joint lesion. We report four clinical cases in which controlled-release oxycodone improved pain intensity in breast cancer patients with severe musculoskeletal pain caused by nab-paclitaxel therapy. In each case, oxycodone was well-tolerated and the symptoms of peripheral neuropathy were quite mild, indicating that oxycodone exhibited a preventive or therapeutic effect on peripheral neuropathy. Therefore, oxycodone may have favorable efficacy and tolerability against cancer therapy-related pain with a neuropathic element in breast cancer patients.
authors.affiliation: Division of Breast Oncology, Saitama Cancer Center.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Inoue
authors.forename: Fumie
authors.initials: F
authors.lastname: Ohkubo
authors.forename: Shigenori
authors.initials: S
authors.lastname: Nagai
authors.forename: Miki
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kubo
authors.forename: Ken
authors.initials: K
authors.lastname: Kurozumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takei
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000009:adverse effects* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000139:chemically induced / Q000188:drug therapy*; D010098:Oxycodone / Q000627:therapeutic use*; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D010098:Oxycodone; D017239:Paclitaxel