title: Second try: who returns for additional assisted reproductive technology treatment and the effect of a prior assisted reproductive technology birth.
abstract: OBJECTIVE
  To evaluate the effect of a prior assisted reproductive technology (ART) live birth on subsequent live-birth rates.
  
  
  METHODS
  Historical cohort study.
  
  
  METHODS
  Clinic-based data.
  
  
  METHODS
  The study population included 297,635 women with 549,278 cycles from 2004 to 2010 from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Try 1 refers to ART cycles up to and including the first live birth, try 2 to ART cycles after a first live birth.
  
  
  METHODS
  None.
  
  
  METHODS
  Live-birth rates by cycle number, try number, and oocyte source.
  
  
  RESULTS
  Younger women at try 1 are more likely to return for try 2. Women returning for try 2 were more likely to have had an ART singleton versus multiple birth (33.2% after a try 1 singleton versus 8.1% after twins and 4.9% after triplets) and were less likely to have a diagnosis of diminished ovarian reserve or tubal factors. Live-birth rates were significantly higher for try 2 compared with try 1 for autologous fresh cycles, averaging 7.7 percentage points higher over five cycles. Live-birth rates were not significantly different for try 2 versus try 1 with thawed autologous cycles or either fresh or thawed donor cycles.
  
  
  CONCLUSIONS
  These results indicate that when fresh autologous oocytes can be used, live-birth rates per cycle are significantly greater after a prior history of an ART live birth.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan. Electronic address: lukeb@msu.edu.
authors.forename: Barbara
authors.initials: B
authors.lastname: Luke
authors.forename: Morton B
authors.initials: MB
authors.lastname: Brown
authors.forename: Ethan
authors.initials: E
authors.lastname: Wantman
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Baker
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Grow
authors.forename: Judy E
authors.initials: JE
authors.lastname: Stern
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Prior ART live birth; autologous cycles; donor cycles; live-birth rates