title: Disruptive innovations: new anti-infectives in the age of resistance.
abstract: This special issue of Current Opinion in Pharmacology is concerned with new developments in antimicrobial drugs and covers innovative strategies for dealing with microbial infection in the age of multi-antibiotic resistance. Despite widespread fears that many infectious diseases may become untreatable, disruptive innovations are in the process of being discovered and developed that may go some way to leading the fight-back against the rising threat. Natural products, quorum sensing inhibitors, biofilm disruptors, gallium-based drugs, cyclodextrin inhibitors of pore-forming toxins, anti-fungals that deal with biofilms, and light based antimicrobial strategies are specifically addressed. New non-vertebrate animal models of infection may facilitate high-throughput screening (HTS) of novel anti-infectives.
authors.affiliation: Center for Molecular Discovery, University of New Mexico, Albuquerque, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA; Department of Dermatology, Harvard Medical School, Boston, MA, USA. Electronic address: gtegos@salud.unm.edu.
authors.forename: George P
authors.initials: GP
authors.lastname: Tegos
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hamblin
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D035843:Biomedical Research; D055808:Drug Discovery; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D062069:Inventions; D053038:Quorum Sensing
chemical_list: D000890:Anti-Infective Agents