title: [Effect of non-surgical periodontal therapy on level of serum soluble intercellular adhesion molecule-1 and glycated hemoglobin A1c in patients with type 2 diabetes and chronic periodontitis].
abstract: OBJECTIVE
  To evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements, glycemic control, and level of serum soluble intercellular adhesion molecule-1 (sICAM-1) in type 2 diabetes mellitus with chronic periodontitis patients.
  
  
  METHODS
  Patients with type 2 diabetes and chronic periodontitis were selected and classified into well-controlled group[glycated hemoglobin Ac(GHbA1)<7.00%, n=30, DMCP1 group] and poorly-controlled group (GHbAc > or = 7.00%, n = 30, DMCP2 group). Thirty systemically healthy patients with chronic periodontitis were recruited as control group (CP group). All subjects underwent non-surgical periodontal therapy. Plaque index(PLI), sulcus bleeding index(SBI), bleeding on probing (BOP), probing depth(PD), clinical attachment loss (CAL), serum sICAM-1 concentration, and the value of fasting plasma glucose(FPG), GHbAc were recorded at baseline, 1 and 3 months after periodontal treatment.
  
  
  RESULTS
  The three study groups showed significant improvements for the levels of PD, SBI, PLI, BOP, and serum sICAM-1 concentration at 1 and 3 months after non-surgical periodontal treatment (P < 0.05). The level of CP group and DMCP1 group also showed significant improvements for the levels of CAL (P < 0.05), but no significant change was found in DMCP2 group (P > 0.05). At 3 months after periodontal treatment, GHbA1c levels in DMCP2 group significantly decreased by 1.12% (P < 0.05), whereas no significant changes were found in CP and DMCT groups (P > 0.05).
  
  
  CONCLUSIONS
  Non-surgical periodontal treatment can siginificantly improve periodontal health status in patients with type 2 diabetes and periodontitis, reduce the level of serum sICAM-1, and can reduce the level of GHbA1c in poorly controlled type 2 diabetic patients.
authors.affiliation: Dept. of Prosthodontics, School of Stomatology, Weifang Medical College, Weifang 261053, China.
authors.forename: Tangxia
authors.initials: T
authors.lastname: Yuan
authors.forename: Yanbiao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Fantao
authors.initials: F
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
mesh_terms: D001786:Blood Glucose; D055113:Chronic Periodontitis; D003774:Dental Plaque Index; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2; D006442:Glycated Hemoglobin; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D010512:Periodontal Index
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D018799:Intercellular Adhesion Molecule-1