title: Urinary creatinine to serum creatinine ratio and renal failure index in dogs infected with Babesia canis.
abstract: Urinary creatinine to serum creatinine (UCr/SCr) ratio and renal failure index (RFI) are useful indices of renal damage. Both UCr/SCr ratio and RFI are used in differentiation between prerenal azotaemia and acute tubular necrosis. In this work the authors calculated the UCr/SCr ratio and RFI in dogs infected with Babesia canis and the values of these indices in azotaemic dogs infected with the parasite. The results of this study showed significantly lower UCr/SCr ratio in dogs infected with B. canis than in healthy dogs. Moreover, in azotaemic dogs infected with B. canis the UCr/SCr ratio was significantly lower and the RFI was significantly higher than in non-azotaemic dogs infected with B. canis. The calculated correlation between RFI and duration of the disease before diagnosis and treatment was high, positive and statistically significant (r = 0.89, p < 0.001). The results of this study showed that during the course of canine babesiosis caused by B. canis in Poland acute tubular necrosis may develop.
authors.affiliation: Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, 02-786, Warsaw, Poland. wojciechzygner@yahoo.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zygner
authors.forename: Olga
authors.initials: O
authors.lastname: Gójska-Zygner
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wesołowska
authors.forename: Halina
authors.initials: H
authors.lastname: Wędrychowicz
mesh_terms: D000818:Animals; D001404:Babesiosis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood* / Q000652:urine*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D011044:Poland; D051437:Renal Insufficiency / Q000175:diagnosis*; D044967:Serum / Q000737:chemistry; D014556:Urine / Q000737:chemistry
chemical_list: D015415:Biomarkers; D003404:Creatinine