title: Compatibility of vancomycin hydrochloride and famotidine 5% dextrose injection.
abstract: The compatibility of vancomycin hydrochloride and famotidine in 5% dextrose injection stored at two temperatures was studied. Vancomycin hydrochloride and famotidine were reconstituted and diluted with 5% dextrose injection to form an admixture with a famotidine concentration of 0.2 mg/mL and a vancomycin concentration of 5 mg/mL. The admixture was stored in 100-mL vented intravenous containers in the dark at 4 and 25 deg C; three containers were stored at each temperature. A 2-mL sample was taken from each container after six and 12 hours and 1, 3, 5, 7, 10, 12, and 14 days of storage and visually inspected, tested for pH and assayed by a developed stability-indicating high performance liquid chromatographic method. Triplicate samples were prepared for each storage condition. No color change, precipitation or cloudiness was observed in any sample at any time during the study. Vancomycin 5 mg/mL and famotidine 0.2 mg/mL in admixtures in 5% dextrose injections are stable for 14 days at 4 and 25 deg C.
authors.affiliation: National Defense Medical Center, Taipei, Taiwan.
authors.forename: D P
authors.initials: DP
authors.lastname: Wang
authors.forename: M T
authors.initials: MT
authors.lastname: Wang
authors.forename: C Y
authors.initials: CY
authors.lastname: Wong
authors.forename: D K
authors.initials: DK
authors.lastname: Lee