title: Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.
abstract: We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.
authors.affiliation: Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan; Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan. Electronic address: ydaisuke-kyoto@umin.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yabe
authors.forename: Mariyo
authors.initials: M
authors.lastname: Rokutan
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Miura
authors.forename: Izumi
authors.initials: I
authors.lastname: Komoto
authors.forename: Ryota
authors.initials: R
authors.lastname: Usui
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kuwata
authors.forename: Koin
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takanori
authors.initials: T
authors.lastname: Hyo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kurose
authors.forename: Terumi
authors.initials: T
authors.lastname: Nagamatsu
authors.forename: Shinobu
authors.initials: S
authors.lastname: Shimizu
authors.forename: Jun
authors.initials: J
authors.lastname: Kawai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Imamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000328:Adult; D001158:Arteries; D002125:Calcium Gluconate / Q000008:administration & dosage; D005502:Food; D005934:Glucagon / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D050416:Glucagon-Secreting Cells / Q000378:metabolism*; D005935:Glucagonoma / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications; D010180:Pancreatectomy
chemical_list: D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D002125:Calcium Gluconate
keywords: GIP; GLP-1; Glucagon-like peptide-1; Glucagonoma; MEN1; Pancreatic α cells; glucagon-like peptide 1; glucose-dependent insulinotropic polypepide; multiple endocrine neoplasia syndrome, type 1