title: A rapid screen for molecules that form duplex to duplex crosslinks in DNA.
abstract: We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome.
authors.affiliation: School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK. d.russell@uea.ac.uk.
authors.forename: María J
authors.initials: MJ
authors.lastname: Marín
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Rackham
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Round
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Howell
authors.forename: David A
authors.initials: DA
authors.lastname: Russell
authors.forename: Mark
authors.initials: M
authors.lastname: Searcey
mesh_terms: D000585:Aminacrine / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry; D009707:Nucleosomes / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008024:Ligands; D009707:Nucleosomes; D006046:Gold; D000585:Aminacrine; D004247:DNA