title: Vaginal epithelioid angiosarcoma: a potential pitfall in gynecologic pathology.
abstract: OBJECTIVE
  Epithelioid angiosarcoma of the vagina is a rare variant that can easily be misdiagnosed considering the much higher frequency of epithelial neoplasms at that particular site.
  
  
  METHODS
  We report the case of a 41-year-old gravida 2, para 1, aborta 1, with no prior history of irradiation, who consulted after the discovery of 3 lesions at the lower right portion of the vagina.
  
  
  RESULTS
  The lesion consisted of epithelioid cells with high-grade nuclei and prominent nucleoli. These cells expressed CD31, CD34, factor VIII, Fli-1, vimentin, smooth muscle actin, and WT-1. Keratin 8/18 was focally positive. They were immunonegative for keratin AE1/AE3, keratin 34βE12, keratin 7, keratin 20, S100, HMB-45, myogenin, desmin, and human herpesvirus type 8. Polymerase chain reaction-based HPV viral search was also negative.
  
  
  CONCLUSIONS
  A broad immunohistochemical panel including antibodies against vascular differentiation markers as well as various cytokeratins allows proper diagnosis of this unusual and aggressive entity.
authors.affiliation: Departments of 1Pathology and 2Radiation Oncology, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame; Departments of 3Pathology and 4Obstetrics and Gynecology, Hôpital Maisonneuve-Rosemont; and 5Division of Gynecologic Oncology, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Richer
authors.forename: Maroie
authors.initials: M
authors.lastname: Barkati
authors.forename: Caroline
authors.initials: C
authors.lastname: Meunier
authors.forename: Suzanne
authors.initials: S
authors.lastname: Fortin
authors.forename: Diane
authors.initials: D
authors.lastname: Provencher
authors.forename: Kurosh
authors.initials: K
authors.lastname: Rahimi
mesh_terms: D000328:Adult; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008853:Microscopy; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000473:pathology*