title: [Effects of omega-3 polyunsaturated fatty acids on antioxidant capacity in rats].
abstract: Dietary administration of omega-3 polyunsaturated fatty acids (EPA + DHA, 1,2:1) at dose 0.3 or 1 g/kg bw during 4 weeks led to minor (by 14% and 17%, p<0.05) decrease of serum antioxidant capacity and serum level of vitamin E (by 30% and 31%, p<0.05) and the activity of paraoxonase-1 (by 14% at 0.3 g/kg bw, p<0.05). The activity of antioxidant enzymes in liver increased in a dose-dependent manner. At higher dose of omega-3 polyunsaturated fatty acids a 45% increase in the activity of paraoxonase-1 (p<0.05), 21% -heme oxygenase-1 (p>0.05), 68% - quinone reductase (p<0.05), 19% - glutathione S-transferase (p<0.05) compared to the control group was found. The direct relationship between activities of enzymes and increase of MDA level in liver (by 47 and 107%, p<O.05) was found. Selected doses of omega-3 polyunsaturatedfatty acids had no significant effects on total liver antioxidant capacity, microsomes NADPH-Fe2+-induced lipid peroxidation and lysosomal membranes stability.
authors.forename: L V
authors.initials: LV
authors.lastname: Kravchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Aksenov
authors.forename: L I
authors.initials: LI
authors.lastname: Avren'eva
authors.forename: N A
authors.initials: NA
authors.lastname: Beketova
authors.forename: N V
authors.initials: NV
authors.lastname: Trusov
authors.forename: G V
authors.initials: GV
authors.lastname: Guseva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D014810:Vitamin E; D010088:Oxidoreductases; C572204:Pon1 protein, rat; D043303:Aryldialkylphosphatase