title: [Neuroprotective potential of akatinol-memantine in ischemic stroke].
abstract: NMDA-mediated excitotoxicity considered as a main cause of neuronal death after stroke. Memantine is a non-competitive NMDA-receptor antagonist. This article reviews the recent results of experimental studies on the efficacy of memantine as an add-on to improve the safety of thrombolytic therapy.
authors.forename: T A
authors.initials: TA
authors.lastname: Makotrova
authors.forename: N A
authors.initials: NA
authors.lastname: Trusova
authors.forename: N I
authors.initials: NI
authors.lastname: Shrader
authors.forename: O S
authors.initials: OS
authors.lastname: Levin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D008559:Memantine / Q000627:therapeutic use*; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D018691:Excitatory Amino Acid Antagonists; D008559:Memantine