title: Effect of methylprednisolone on bone mineral density in rats with ovariectomy-induced bone loss and suppressed endogenous adrenaline levels by metyrosine.
abstract: OBJECTIVE
  In this study, effect of methylprednisolone on bone mineral density (BMD) was investigated in rats with overiectomy induced bone lose and suppressed endogenous adrenalin levels, and compared to alendronate.
  
  
  METHODS
  Severity of bone loss in the examined material (femur bones) was evaluated by BMD measurement.
  
  
  RESULTS
  The group with the highest BMD value was metyrosinemetyrosine + methylprednisolone combination (0.151 g/cm(2)), while that with the lowest BMD was methylprednisolone (0.123 g/cm(2)). Alendronate was effective only when used alone in ovariectomized rats (0.144 g/cm(2)), but not when used in combination with methylprednisolone (0.124 g/cm(2)). In the ovariectomized rat group which received only metyrosine, BMD value was statistically indifferent from ovariectomized control group.
  
  
  CONCLUSIONS
  Methylprednisolone protected bone loss in rats with suppressed adrenaline levels because of metyrosinemetyrosine.
authors.affiliation: Department of Obstetrics and Gynecology, Ataturk University, Faculty of Medicine, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Unal
authors.initials: U
authors.lastname: Isaoglu
authors.forename: Turan
authors.initials: T
authors.lastname: Uslu
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.forename: Bedri
authors.initials: B
authors.lastname: Seven
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Hacimuftuoglu
mesh_terms: D019386:Alendronate / Q000008:administration & dosage; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D005269:Femur / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000008:administration & dosage*; D008775:Methylprednisolone / Q000008:administration & dosage*; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D019805:alpha-Methyltyrosine / Q000008:administration & dosage*
chemical_list: D050071:Bone Density Conservation Agents; D005938:Glucocorticoids; D019805:alpha-Methyltyrosine; D019386:Alendronate; D008775:Methylprednisolone; D004837:Epinephrine
keywords: Bone mineral density; bone loss; methylprednisolone; metirosine; osteoporosis; ovariectomy