title: β -Glucosidases from the fungus trichoderma: an efficient cellulase machinery in biotechnological applications.
abstract: β-glucosidases catalyze the selective cleavage of glucosidic linkages and are an important class of enzymes having significant prospects in industrial biotechnology. These are classified in family 1 and family 3 of glycosyl hydrolase family. β-glucosidases, particularly from the fungus Trichoderma, are widely recognized and used for the saccharification of cellulosic biomass for biofuel production. With the rising trends in energy crisis and depletion of fossil fuels, alternative strategies for renewable energy sources need to be developed. However, the major limitation accounts for low production of β-glucosidases by the hyper secretory strains of Trichoderma. In accordance with the increasing significance of β-glucosidases in commercial applications, the present review provides a detailed insight of the enzyme family, their classification, structural parameters, properties, and studies at the genomics and proteomics levels. Furthermore, the paper discusses the enhancement strategies employed for their utilization in biofuel generation. Therefore, β-glucosidases are prospective toolbox in bioethanol production, and in the near future, it might be successful in meeting the requirements of alternative renewable sources of energy.
authors.affiliation: Metabolic and Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226015, Uttar Pradesh, India.
authors.forename: Pragya
authors.initials: P
authors.lastname: Tiwari
authors.forename: B N
authors.initials: BN
authors.lastname: Misra
authors.forename: Neelam S
authors.initials: NS
authors.lastname: Sangwan
mesh_terms: D001709:Biotechnology / Q000379:methods*; D044602:Cellulases / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism*; D010802:Phylogeny; D014242:Trichoderma / Q000145:classification / Q000201:enzymology* / Q000235:genetics
chemical_list: D044602:Cellulases