title: Liver dysfunction and thrombocytopenia diagnosed as intravascular large B-cell lymphoma using a timely and accurate transjugular liver biopsy.
abstract: A 72-year-old man suffered from paraparesis with a sensory impairment and bladder and rectal disturbances. Magnetic resonance imaging T2-weighted images depicted a high-intensity lesion in the spinal cord that was consistent with myelitis. A blood examination revealed severe thrombocytopenia and liver dysfunction. No malignant cells were detected by peripheral smears or bone marrow biopsy. Systemic computed tomography detected hepatosplenomegaly and ascites but no lymphadenopathies. Transjugular liver biopsy (TJLB) safely confirmed a diagnosis of intravascular large B-cell lymphoma (IVLBCL), and the patient achieved a complete response following treatment with an appropriate chemotherapy. TJLB is therefore a timely and accurate diagnostic approach for IVLBCL, especially when a bleeding tendency and ascites are noted.
authors.affiliation: Department of Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Nodoka
authors.initials: N
authors.lastname: Sekiguchi
authors.forename: Satoru
authors.initials: S
authors.lastname: Joshita
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurozumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sano
authors.forename: Michitaka
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Daisuke
authors.initials: D
authors.lastname: Komatsu
authors.forename: Michiharu
authors.initials: M
authors.lastname: Komatsu
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.forename: Takeji
authors.initials: T
authors.lastname: Umemura
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Masumi
authors.initials: M
authors.lastname: Kadoya
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ishida
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D007601:Jugular Veins; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis*; D008297:Male; D013921:Thrombocytopenia / Q000150:complications / Q000175:diagnosis*; D013997:Time Factors