title: Effect of liver transplantation on brain magnetic resonance imaging pathology in Wilson disease: a case report.
abstract: The authors present a case report of a 28-year-old patient with hepatic, but no neurological, signs of Wilson disease, with pathological changes in both the globi pallidi and caudate found with routine brain magnetic resonance imaging (MRI). The patient was recommended for liver transplantation by hepatologists, and during the two years of observation after liver transplantation, MRI brain abnormalities due to Wilson disease completely regressed. On the basis of this case, the authors present an argument for the prognostic significance of brain MRI in Wilson disease as well as current recommendations concerning liver transplantation in Wilson disease.
authors.affiliation: Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland. tomlit@medprakt.pl
authors.forename: T
authors.initials: T
authors.lastname: Litwin
authors.forename: K
authors.initials: K
authors.lastname: Dzieżyc
authors.forename: R
authors.initials: R
authors.lastname: Poniatowska
authors.forename: A
authors.initials: A
authors.lastname: Członkowska
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000473:pathology; D015913:Chelation Therapy; D005917:Globus Pallidus / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging