title: [Immunogenetic aspects of early rheumatoid arthritis].
abstract: The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.
authors.forename: I A
authors.initials: IA
authors.lastname: Guseva
authors.forename: N V
authors.initials: NV
authors.lastname: Demidova
authors.forename: N E
authors.initials: NE
authors.lastname: Soroka
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: E L
authors.initials: EL
authors.lastname: Luchikhina
authors.forename: E N
authors.initials: EN
authors.lastname: Aleksandrova
authors.forename: G V
authors.initials: GV
authors.lastname: Lukina
authors.forename: E V
authors.initials: EV
authors.lastname: Fedorenko
authors.forename: E S
authors.initials: ES
authors.lastname: Aronova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Samarkina
authors.forename: M N
authors.initials: MN
authors.lastname: Boldyreva
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Trofimov
authors.forename: D E
authors.initials: DE
authors.lastname: Karateev
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000235:genetics* / Q000276:immunology; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012213:Rheumatic Fever / Q000235:genetics / Q000276:immunology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers