title: The relationship between glycemic control and BNP levels in diabetic patients.
abstract: BACKGROUND
  Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved.
  
  
  METHODS
  The study was performed in a prospective design. The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved.
  
  
  RESULTS
  A significant decrease in BNP (95.0 [4.0-1807] ng/L vs. 52.0 [2.1-987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS).
  
  
  CONCLUSIONS
  We conclude that poor glycemic control may cause high levels of BNP which may lead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.
authors.forename: Kursat
authors.initials: K
authors.lastname: Dal
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.affiliation: Kecioren Teaching and Research Hospital Department of Cardiology. byavuzmd@gmail.com.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Yavuz
authors.forename: Omer
authors.initials: O
authors.lastname: Sen
authors.forename: Onur Sinan
authors.initials: OS
authors.lastname: Deveci
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Aksoz
authors.forename: Aslihan Mete
authors.initials: AM
authors.lastname: Yildirim
authors.forename: Bulent
authors.initials: B
authors.lastname: Uygungelen
authors.forename: Kadir Okhan
authors.initials: KO
authors.lastname: Akin
authors.forename: Esin
authors.initials: E
authors.lastname: Beyan
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006333:Heart Failure / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D020097:Natriuretic Peptide, Brain