title: Microwave assisted synthesis of acrylamide grafted locust bean gum and its application in drug delivery.
abstract: Acrylamide grafted copolymer of locust bean gum was prepared by microwave irradiation using ceric ammonium nitrate as redox initiator. The grafting process was optimized in terms of irradiation time, amount of initiator and acrylamide by using constant amount of native locust bean gum. The grafted gum was characterized by Fourier transform infrared spectroscopy (FT-IR), (13)C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), X-ray diffraction study (XRD), differential scanning calorimetry (DSC), elemental analysis, contact angle, viscosity, molecular weight, swelling and biodegradability studies. The grafted gum was found to be biodegradable and non-toxic. It was further used to prepare controlled-release matrix tablet of buflomedil hydrochloride. The in vitro release profile of the tablet showed the rate controlling property of acrylamide grafted locust bean gum was similar to that of hydroxypropyl methylcellulose (HPMC-K15M).
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Kaity
authors.forename: Jinu
authors.initials: J
authors.lastname: Isaac
authors.forename: P Mahesh
authors.initials: PM
authors.lastname: Kumar
authors.forename: Anirbandeep
authors.initials: A
authors.lastname: Bose
authors.forename: Tin Wui
authors.initials: TW
authors.lastname: Wong
authors.forename: Animesh
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000818:Animals; D060326:Chemistry Techniques, Synthetic; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D005685:Galactans / Q000737:chemistry*; D006207:Half-Life; D008351:Mannans / Q000737:chemistry*; D051379:Mice; D008872:Microwaves; D053149:Plant Gums / Q000737:chemistry*; D011759:Pyrrolidines / Q000097:blood / Q000737:chemistry; D012995:Solubility; D018675:Toxicity Tests; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011759:Pyrrolidines; D014867:Water; D020106:Acrylamide; C017471:locust bean gum; C010651:buflomedil
keywords: Acrylamide grafted locust bean gum; Am; Am-g-LBG; BH; Biodegradable; Buflomedil hydrochloride; C; CAN; Controlled-release; DSC; FTIR; Fourier transform infrared; HPMC; KBr; LBG; N; O; SEM; UV–vis; X-ray diffraction; XRD; acrylamide; acrylamide grafted locust bean gum; buflomedil hydrochloride; carbon; ceric ammonium nitrate; differential scanning calorimetry; hydroxypropyl methylcellulose; locust bean gum; nitrogen; oxygen; potassium bromide; scanning electron microscopy; ultraviolet–visible