title: Lipid antigens in immunity.
abstract: Lipids are not only a central part of human metabolism but also play diverse and critical roles in the immune system. As such, they can act as ligands of lipid-activated nuclear receptors, control inflammatory signaling through bioactive lipids such as prostaglandins, leukotrienes, lipoxins, resolvins, and protectins, and modulate immunity as intracellular phospholipid- or sphingolipid-derived signaling mediators. In addition, lipids can serve as antigens and regulate immunity through the activation of lipid-reactive T cells, which is the topic of this review. We will provide an overview of the mechanisms of lipid antigen presentation, the biology of lipid-reactive T cells, and their contribution to immunity.
authors.forename: C Marie
authors.initials: CM
authors.lastname: Dowds
authors.forename: Sabin-Christin
authors.initials: SC
authors.lastname: Kornell
authors.forename: Richard S
authors.initials: RS
authors.lastname: Blumberg
authors.forename: Sebastian
authors.initials: S
authors.lastname: Zeissig
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008055:Lipids / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D000941:Antigens; D008055:Lipids