title: Antitumor, antioxidant and antimicrobial studies of substituted pyridylguanidines.
abstract: A series of N-pivaloyl-N'-(alkyl/aryl)-N''-pyridylguanidine of general formula C₄H₉CONHC(NR¹R²)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. msaidqau@yahoo.com
authors.forename: Muhammad
authors.initials: M
authors.lastname: Said
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.forename: Naseer Ali
authors.initials: NA
authors.lastname: Shah
authors.forename: Hizbullah
authors.initials: H
authors.lastname: Khan
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
authors.forename: Boris
authors.initials: B
authors.lastname: Vabre
authors.forename: Davit
authors.initials: D
authors.lastname: Zargarian
authors.forename: Muhammad Rashid
authors.initials: MR
authors.lastname: Khan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D052978:Disk Diffusion Antimicrobial Tests / Q000592:standards; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology*; D005609:Free Radicals; D006146:Guanidines / Q000138:chemical synthesis / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D010851:Picrates / Q000737:chemistry; D010941:Plant Tumors / Q000382:microbiology; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D012015:Reference Standards; D014750:Vincristine / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D006146:Guanidines; D010851:Picrates; D011725:Pyridines; D014750:Vincristine; C004931:1,1-diphenyl-2-picrylhydrazyl