title: Functions of class V myosins in neurons.
abstract: This minireview focuses on recent studies implicating class V myosins in organelle and macromolecule transport within neurons. These studies reveal that class V myosins play important roles in a wide range of fundamental processes occurring within neurons, including the transport into dendritic spines of organelles that support synaptic plasticity, the establishment of neuronal shape, the specification of polarized cargo transport, and the subcellular localization of mRNA.
authors.affiliation: From the Cell Biology and Physiology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 and.
authors.forename: John A
authors.initials: JA
authors.lastname: Hammer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wagner
mesh_terms: D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D024701:Myosin Type V / Q000378:metabolism*; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism
chemical_list: D024701:Myosin Type V
keywords: Cell Polarity; Endoplasmic Reticulum (ER); Ionotropic Glutamate Receptors (AMPA, NMDA); Myosin; Neurons; PTEN; Rab Proteins; Receptor Recycling; Synaptic Plasticity; mRNA