title: Association of the GCKR rs780094 polymorphism with metabolic traits including carotid intima-media thickness in Japanese community-dwelling men, but not in women.
abstract: BACKGROUND
  The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population.
  
  
  METHODS
  A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated.
  
  
  RESULTS
  GCKR rs780094 AA genotype was significantly associated with higher TG (p<0.001 vs. GG), lower HDL-C (p=0.021 vs. GG), and lower HbA1c(p=0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p=0.001 vs. GX). These associations were seen only in men.
  
  
  CONCLUSIONS
  GCKR rs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.
authors.forename: Fumi
authors.initials: F
authors.lastname: Murata-Mori
authors.forename: Naomi
authors.initials: N
authors.lastname: Hayashida
authors.forename: Takao
authors.initials: T
authors.lastname: Ando
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ikeoka
authors.forename: Mio
authors.initials: M
authors.lastname: Nakazato
authors.forename: Harutaka
authors.initials: H
authors.lastname: Sekita
authors.forename: Norio
authors.initials: N
authors.lastname: Abiru
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005838:Genotype; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D014280:Triglycerides; C485100:GCKR protein, human