title: Roadblocks to translational advances on metastasis research.
abstract: Promising advances in cancer therapy stemming from an increasing understanding of the molecular and genetic underpinnings of the tumorigenic process have been fueled by a strong, determined scientific community, influential patient advocacy groups and committed funding bodies. Despite these efforts, the development of effective drugs to prevent systemic dissemination of cancer cells or to eliminate overt metastasis in secondary organs remains a challenge to both researchers and physicians. In an attempt to tackle the most relevant and timely translational issues, a meeting held in 2012 as a result of a successful partnership between the Volkswagen Foundation and Nature Medicine brought together a group of metastasis research experts to identify the most important hurdles and help create a framework for potential clinical and translational strategies.
authors.affiliation: 1] Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Freiburg, Germany. [2].
authors.forename: Thomas
authors.initials: T
authors.lastname: Brabletz
authors.forename: David
authors.initials: D
authors.lastname: Lyden
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Steeg
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
mesh_terms: D055808:Drug Discovery; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D057170:Translational Research, Biomedical