title: Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis.
abstract: BACKGROUND
  Hydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of hydrocellular foam dressing on hyaluronan, which has been shown to have positive effects on wound healing, and examined its regulatory mechanisms in rat skin.
  
  
  RESULTS
  We created two full-thickness wounds on the dorsolateral skin of rats. Each wound was covered with either a hydrocellular foam dressing or a film dressing and hyaluronan levels in the periwound skin was measured. We also investigated the mechanism by which the hydrocellular foam dressing regulates hyaluronan production by measuring the gene expression of hyaluronan synthase 3 (Has3), peroxisome proliferator-activated receptor α (PPARα), and CD44. Hydrocellular foam dressing promoted wound healing and upregulated hyaluronan synthesis, along with an increase in the mRNA levels of Has3, which plays a primary role in hyaluronan synthesis in epidermis. In addition, hydrocellular foam dressing enhanced the mRNA levels of PPARα, which upregulates Has3 gene expression, and the major hyaluronan receptor CD44.
  
  
  CONCLUSIONS
  These findings suggests that hydrocellular foam dressing may be beneficial for wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. We believe that the present study would contribute to the elucidation of the mechanisms underlying the effects of hydrocellular foam dressing-induced moist environment on wound healing and practice evidence-based wound care.
authors.affiliation: Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.forename: Gojiro
authors.initials: G
authors.lastname: Nakagami
authors.forename: Sawako
authors.initials: S
authors.lastname: Yoshino
authors.forename: Aimi
authors.initials: A
authors.lastname: Muramatsu
authors.forename: Sho
authors.initials: S
authors.lastname: Matsui
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Minematsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sanada
mesh_terms: D000818:Animals; D001458:Bandages; D001483:Base Sequence; D017931:DNA Primers; D014453:Glucuronosyltransferase / Q000235:genetics*; D000076002:Hyaluronan Synthases; D047493:PPAR alpha / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D060888:Real-Time Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D017931:DNA Primers; D047493:PPAR alpha; D012333:RNA, Messenger; D014453:Glucuronosyltransferase; C491355:Has3 protein, rat; D000076002:Hyaluronan Synthases