title: [Successful resection of lung cancer with idiopathic pulmonary fibrosis treated by pirfenidone during perioperative period].
abstract: We report a case of lung cancer treated with pirfenidone as preoperative therapy before subsequent successful surgical resection. A 76-year-old man was admitted to our hospital because of abnormal shadows and diffuse reticular shadow in bilateral lung on chest computed tomography(CT). CT-guided percutaneous lung biopsy confirmed suquamous cell carcinoma for both lung. Pulmonary reticular shadow was diagnosed as idiopathic pulmonary fibrosis (IPF) clinically and the pirfenidone was administered 600 mg daily and increased by 600 mg for every week until 1,800 mg/day to control IPF. After 3 weeks pirfenidone therapy, Krebs von den Lungen( KL)-6, pulmonary surfactant( SP)-D and lactate dehydrogenase (LDH) decreased, and the patient underwent wedge resection. His postoperative course was uneventful.
authors.affiliation: Department of Thoracic Surgery, Matsusaka Chuo General Hospital, Matsusaka, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Shomura
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katayama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusagawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Komada
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications*; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D059035:Perioperative Period; D011728:Pyridones / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D011728:Pyridones; C093844:pirfenidone