title: Coeliac disease-associated antibodies in psoriasis.
abstract: BACKGROUND
  The possible relationship between psoriasis and coeliac disease (CD) has been attributed to the common pathogenic mechanisms of the two diseases and the presence of antigliadin antibodies in patients has been reported to increase the incidence of CD.
  
  
  OBJECTIVE
  The aim of this report was to study CD-associated antibodies serum antigliadin antibody immunoglobulin (Ig)A, IgG, anti-endomysial antibody IgA and anti-transglutaminase antibody IgA and to demonstrate whether there is an increase in the frequency of those markers of CD in patients with psoriasis.
  
  
  METHODS
  Serum antigliadin antibody IgG and IgA, antiendomysial antibody IgA and anti-transglutaminase antibody IgA were studied in 37 (19 males) patients with psoriasis and 50 (23 males) healthy controls. Upper gastrointestinal endoscopy and duodenal biopsies were performed in patients with at least one positive marker.
  
  
  RESULTS
  Antigliadin IgA was statistically higher in the psoriasis group than in the controls (p<0.05). Serological markers were found positive in 6 patients with psoriasis and 1 person from the control group. Upper gastrointestinal endoscopy was performed in all these persons, with biopsies collected from the duodenum. The diagnosis of CD was reported in only one patient with psoriasis following the pathological examination of the biopsies. Whereas one person of the control group was found to be positive for antigliadin antibody IgA, pathological examination of the duodenal biopsies obtain from this patient were found to be normal.
  
  
  CONCLUSIONS
  Antigliadin IgA prominently increases in patients diagnosed with psoriasis. Patients with psoriasis should be investigated for latent CD and should be followed up.
authors.affiliation: Department of Gastroenterology, Kartal Kosuyolu High Speciality Education and Research Hospital, Istanbul, Turkey.
authors.forename: Sabiye
authors.initials: S
authors.lastname: Akbulut
authors.forename: Günes
authors.initials: G
authors.lastname: Gür
authors.forename: Firdevs
authors.initials: F
authors.lastname: Topal
authors.forename: Engin
authors.initials: E
authors.lastname: Senel
authors.forename: Fatih Esad
authors.initials: FE
authors.lastname: Topal
authors.forename: Nuran
authors.initials: N
authors.lastname: Alli
authors.forename: Ulkü
authors.initials: U
authors.lastname: Saritas
keywords: Antibodies; Celiac disease; Duodenum; Psoriasis