title: Low-temperature Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds.
abstract: Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to α,β-unsaturated carbonyl compounds was achieved at temperatures below 0 °C using a Rh/MeO-F12-BIPHEP catalyst. The reaction of cyclohexenone or N-R-maleimide with arylboronic acids proceeded even at -80 °C in the presence of the Rh catalyst. In the latter case, high enantioselectivity was observed because a low-temperature method was used, regardless of the type of substituent on maleimide.
authors.affiliation: Department of Chemistry and Bioengineering, Faculty of Engineering, Iwate University , 4-3-5 Ueda, Morioka, Iwate 020-8551, Japan.
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Korenaga
authors.forename: Aram
authors.initials: A
authors.lastname: Ko
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimada