title: Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer.
abstract: It is well known that non-canonical IκB kinases (IKK), IKKϵ and Tank-binding kinase 1 (TBK1), play a key role in anti-viral responses. Interestingly, they have recently emerged as novel survival kinases in several human cancers including lung cancer, given their roles in maintaining cancer cell survival and promoting oncogenic transformation. However, the molecular mechanisms by which IKKϵ/TBK1 are activated and IKKϵ/TBK1 mediate survival signal in cancer cells are still controversial. This article will briefly describe signaling pathways mediated by these non-canonical IKKs, especially focusing in lung cancer, and discuss their potential as molecular targets for lung cancer treatment.
authors.affiliation: H. Lee Moffitt Cancer Center and Research Institute, Department of Thoracic Oncology and Chemical Biology and Molecular Medicine Program , 12902 Magnolia Dr. Tampa, FL 33612 , USA eric.haura@moffitt.org.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Amer A
authors.initials: AA
authors.lastname: Beg
authors.forename: Eric B
authors.initials: EB
authors.lastname: Haura
mesh_terms: D000818:Animals; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017346:Protein Serine-Threonine Kinases; C403191:TBK1 protein, human; D051550:I-kappa B Kinase