title: Three single nucleotide polymorphisms of the vascular endothelial growth factor (VEGF) gene and glioma risk in a Chinese population.
abstract: OBJECTIVE
  To investigate the association between three single nucleotide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene and the risk of glioma in a Han Chinese population.
  
  
  METHODS
  This hospital-based case-control study used polymerase chain reaction-restriction fragment length polymorphism analysis to detect three SNPs (-634 G/C, +936 C/T and +1612 G/A) of the VEGF gene in patients with glioma compared with healthy control subjects.
  
  
  RESULTS
  The study investigated 880 patients with gliomas and 880 age- and sex-matched healthy control subjects. Patients with gliomas had a significantly higher frequency of the -634 CC genotype (odds ratio [OR] 1.35, 95% confidence interval [CI] 1.05, 1.75) and the +936 TT (OR 1.73, 95% CI 1.20, 2.48) genotype compared with the control subjects. Patients with glioblastomas had a significantly higher frequency of the -634 CC and +936 TT genotypes. Patients with grade IV gliomas had a significantly higher frequency of the -634 CC and +936 TT genotypes. The +1612 G/A polymorphisms were not associated with glioma risk.
  
  
  CONCLUSIONS
  The VEGF - 634 CC and +936 TT genotypes were associated with a higher risk of glioma in a Han Chinese population.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Jiang
authors.forename: Minxue
authors.initials: M
authors.lastname: Lian
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Xie
authors.forename: Jinzheng
authors.initials: J
authors.lastname: Li
authors.forename: Maode
authors.initials: M
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005910:Glioma / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic; D012306:Risk; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Glioma; VEGF; gene polymorphism; vascular endothelial growth factor