title: Au-Cu(2-x)Se heterodimer nanoparticles with broad localized surface plasmon resonance as contrast agents for deep tissue imaging.
abstract: We report a new type of heterogeneous nanoparticles (NPs) composed of a heavily doped semiconductor domain (Cu2-xSe) and a metal domain (Au), which exhibit a broad localized surface plasmon resonance (LSPR) across visible and near-infrared (NIR) wavelengths, arising from interactions between the two nanocrystal domains. We demonstrate both in vivo photoacoustic imaging and in vitro dark field imaging, using the broad LSPR in Cu2-xSe-Au hybrid NPs to achieve contrast at different wavelengths. The high photoacoustic imaging depth achieved, up to 17 mm, shows that these novel contrast agents could be clinically relevant. More broadly, this work demonstrates a new strategy for tuning LSPR absorbance by engineering the density of free charge carriers in two interacting domains.
authors.affiliation: Department of Chemical and Biological Engineering, University at Buffalo (SUNY) , Buffalo, New York 14260, United States.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Changho
authors.initials: C
authors.lastname: Lee
authors.forename: Wing-Cheung
authors.initials: WC
authors.lastname: Law
authors.forename: Dewei
authors.initials: D
authors.lastname: Zhu
authors.forename: Maixian
authors.initials: M
authors.lastname: Liu
authors.forename: Mansik
authors.initials: M
authors.lastname: Jeon
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Kim
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
authors.forename: Mark T
authors.initials: MT
authors.lastname: Swihart
mesh_terms: D003287:Contrast Media / Q000737:chemistry / Q000145:classification; D003300:Copper / Q000737:chemistry; D003952:Diagnostic Imaging; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry; D012666:Semiconductors; D020349:Surface Plasmon Resonance
chemical_list: D003287:Contrast Media; D006046:Gold; D003300:Copper; D012643:Selenium