title: Development of monetite/phosphorylated chitosan composite bone cement.
abstract: In this article, we report the development of a biodegradable monetite [dicalcium phosphate anhydrous (DCPA), CaHPO4 ]/phosphorylated chitosan (p-chitosan) composite orthopedic cement. The cement pastes showed desirable handling properties, injectability, and washout resistance. The incorporation of p-chitosan powders at 5 wt % shortened the setting time of DCPA and significantly improved the mechanical performance of DCPA cement, increasing the compressive strength almost twice from 11.09 ± 1.85 MPa at 0% chitosan to 23.43 ± 1.47 MPa at 5 wt % p-chitosan. On the other hand, higher p-chitosan content or untreated chitosan incorporation lowered the performance of DCPA cements. The cytocompatibility of the composite cement was investigated in vitro using the preosteoblast cell line MC3T3-E1. An increase in cell proliferation was observed in both DCPA and DCPA-p-chitosan. The results show that both the materials are as cytocompatible as hydroxyapatite. Based on these results, DCPA-p-chitosan composite cement can be considered as potential bone repair material.
authors.affiliation: Department of Mechanical, Industrial and Manufacturing Engineering, The University of Toledo, Toledo, Ohio.
authors.forename: Nariman Mansouri
authors.initials: NM
authors.lastname: Boroujeni
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.forename: Timothy J F
authors.initials: TJ
authors.lastname: Luchini
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D048271:Chitosan; C485829:calcium phosphate, dibasic, anhydrous
keywords: bone cement; chitosan; composite; monetite