title: Associations of genetic polymorphisms of SAA1 with cerebral infarction.
abstract: BACKGROUND
  Serum amyloid A protein (SAA) is both an inflammatory factor and an apolipoprotein. However, the relation between genetic polymorphisms of SAA and cerebral infarction (CI) remains unclear.
  
  
  RESULTS
  The previously reported 4 Single Nucleotide Polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of SAA1 gene were genotyped by TaqMan method in a case-control study including 287 cerebral infarction patients and 376 control subjects. We found rs12218 CC genotype and rs7131332 AA genotype were more frequent among CI patients than among controls (9.76% versus 3.19%, P = 0.001; 32.75% versus 24.20%; p = 0.017; respectively). After adjustment of confounding factors such as sex, age, smoking, drinking, hypertension, diabetes, and lipids profile, the difference remained significant in rs12218 (P < 0.01, OR = 2.106, 95% CI: 1.811-7.121).
  
  
  CONCLUSIONS
  Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453100, P R, China. zhaojianhua_z@126.com.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Yuan
authors.forename: He-Hua
authors.initials: HH
authors.lastname: Li
authors.forename: Sheng-Bo
authors.initials: SB
authors.lastname: Tao
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Yan
authors.forename: Li
authors.initials: L
authors.lastname: Chang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000208:ethnology / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000685:Serum Amyloid A Protein / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein