title: Hantzsch based macrocyclization approach for the synthesis of thiazole containing cyclopeptides.
abstract: An innovative macrocyclization approach via high-yielding solid-phase intramolecular thioalkylation reaction is described. The reaction of S-nucleophiles with newly generated N-terminal 4-chloromethyl thiazoles leads to the desired cyclic products in high purities and good yields.
authors.affiliation: Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA.
authors.forename: Adel
authors.initials: A
authors.lastname: Nefzi
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D010455:Peptides / Q000138:chemical synthesis; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles