title: The tableting properties of melibiose monohydrate.
abstract: In this research, the tableting properties of α-melibiose monohydrate were studied. Melibiose is a disaccharide which bears structural resemblance to lactose, because they both consist of galactose and glucose monosaccharide subunits. Compactibility and deformation behavior of two melibiose batches from different suppliers were studied and compared with α-lactose monohydrate and some other typical tableting excipients. Differences in the deformation behavior were determined comparing the shape of the Heckel plots, the yield pressure values and the strain rate sensitivity (SRS) indexes. In addition, the effect of moisture on the tabletability was studied. According to the yield pressures and SRS indexes melibiose was concluded to be fragmenting, even at higher degree than lactose monohydrate. However, the overall deformation behavior of melibiose was found to be similar to that of lactose monohydrate. Increase in moisture content resulted in higher tensile strengths of tablets for both melibiose batches, but it seemed to have more effect on compactibility of the other batch. In conclusion, melibiose has potential to be used as an excipient in tablet formulations.
authors.affiliation: Division of Pharmaceutical Technology, University of Helsinki, P.O. Box 56 (Viikinkaari 5E) 00014, Finland. Electronic address: satu.lakio@gmail.com.
authors.forename: Satu
authors.initials: S
authors.lastname: Lakio
authors.forename: Janne
authors.initials: J
authors.lastname: Sainio
authors.forename: Petteri
authors.initials: P
authors.lastname: Heljo
authors.forename: Tuomas
authors.initials: T
authors.lastname: Ervasti
authors.forename: Niina
authors.initials: N
authors.lastname: Kivikero
authors.forename: Anne
authors.initials: A
authors.lastname: Juppo
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D008553:Melibiose / Q000032:analysis / Q000737:chemistry*; D010316:Particle Size; D013607:Tablets
chemical_list: D013607:Tablets; D008553:Melibiose
keywords: Compactibility; Deformation; Excipient; Lactose; Melibiose; Tableting