title: Oral exposure to cylindrospermopsin in pregnant rats: reproduction and foetal toxicity studies.
abstract: Cylindrospermopsin (CYN) induces toxicity in pregnant mice when administered intraperitoneally. This study investigated whether oral exposure to CYN (0.03, 0.3 and 3 μg/kg) during pregnancy causes toxic effects and impairs gestation in rats. The results of reproductive performance and teratology studies were similar between the control and experimental dams. Our findings suggest that CYN consumption within the guideline values for drinking water is not able to promote foetal toxicity or alterations in rat reproductive performance.
authors.affiliation: Department of Clinical and Toxicological Analysis, Center for Health Sciences, Federal University of Rio Grande do Norte, Rua General Gustavo Cordeiro de Farias s/n, 59012570 Natal, RN, Brazil.
authors.forename: Cristhiano
authors.initials: C
authors.lastname: Sibaldo de Almeida
authors.forename: Andrea Caroline
authors.initials: AC
authors.lastname: Costa de Arruda
authors.forename: Erika
authors.initials: E
authors.lastname: Caldas de Queiroz
authors.forename: Haline Tereza
authors.initials: HT
authors.lastname: Matias de Lima Costa
authors.forename: Patrícia Fernandes
authors.initials: PF
authors.lastname: Barbosa
authors.forename: Telma Maria
authors.initials: TM
authors.lastname: Araújo Moura Lemos
authors.forename: Cláudia Nunes
authors.initials: CN
authors.lastname: Oliveira
authors.forename: Ernani
authors.initials: E
authors.lastname: Pinto
authors.forename: Aline
authors.initials: A
authors.lastname: Schwarz
authors.forename: Paula
authors.initials: P
authors.lastname: Kujbida
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids; D000818:Animals; D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D004353:Drug Evaluation, Preclinical; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D023382:Toxicity Tests, Acute; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D000470:Alkaloids; D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; C089595:cylindrospermopsin; D014498:Uracil
keywords: Cylindrospermopsin; Foetus; Rat; Reproduction; Toxicity