title: Enhanced production of a self-toxic antibiotic xinghaiamine A from the novel marine-derived species Streptomyces xinghaiensis by resin addition.
abstract: An addition of 3% (w/v) adsorbent resin HP-20 at 3 days post-inoculation significantly improved xinghaiamine A production from 0.35 to 3.4 mg/L and shortened fermentation time from 18 to 9 days. Self-cytotoxicity of xinghaiamine A was verified and the minimal inhibitor concentration was estimated to be 8 μg/mL.
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116023, China.
authors.forename: Wen-Ce
authors.initials: WC
authors.lastname: Jiao
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116023, China. Electronic address: xqzhao@dlut.edu.cn.
authors.forename: Xinqing
authors.initials: X
authors.lastname: Zhao
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116023, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116023, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Geng
mesh_terms: D000327:Adsorption; D000470:Alkaloids / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry / Q000633:toxicity*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000737:chemistry / Q000633:toxicity*; D059001:Aquatic Organisms / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D012117:Resins, Synthetic; D013302:Streptomyces / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D012117:Resins, Synthetic; C587994:xinghaiamine A
keywords: Antibiotic production; Resin HP-20; Self-cytotoxic effects; Staphylococcus aureus; Streptomyces xinghaiensis