title: [Validation of the PRIDE Scale (Primary Immunodeficiency Disease Evaluation) to Determine High Level of Suspicion for Primary Immunodeficiency Disease in Mexican Population].
abstract: BACKGROUND
  Primary immunodeficiencies have a low prevalence, but their severity and high risk of mortality require a clinical approach based in diagnostic instruments that allow their early detection.
  
  
  OBJECTIVE
  To validate the PRIDE scale to determine a high level of suspicion for primary immunodeficiency diseases in Mexican population.
  
  
  METHODS
  Seventy five patients with suspicion of primary immunodeficiencies (13.9 ±11.8 years-old) were evaluated with the PRIDE scale by specialists in Allergy and Immunology in this cross-sectional study, and their results were compared with the confirmed diagnosis of primary immunodeficiency.
  
  
  RESULTS
  Kappa concordance coefficient with clinical diagnosis was 0.872, with an standard error of 0.072; CI 95% [0.73-1.013]. The scale showed sensitivity 98.3%, specificity 86.6%, positive predictive value 96.7%, negative predictive value 92.8%, positive odds ratio 7.3358 and negative odds ratio 0.0196.
  
  
  CONCLUSIONS
  PRIDE scale was concordant with the diagnosis of primary immunodeficiency in the majority of patients with a previous confirmed diagnosis. The characteristics of diagnostic accuracy provide reliability to this instrument in the scrutiny of patients with probable immunodeficiency.
authors.affiliation: Servicio de Alergia e InmunologÌa ClÌnica, Hospital de Especialidades Dr Antonio Fraga Mouret, Centro MÈdico Nacional La Raza, IMSS, MÈxico D.F. doloresmogica@hotmail.com.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Mogica-Martínez
authors.forename: Arturo
authors.initials: A
authors.lastname: Velázquez-Leduc
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Ortega-Martell
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez-Alonso
authors.forename: Alain R
authors.initials: AR
authors.lastname: Rodriguez-Orozco
authors.forename: Marisol
authors.initials: M
authors.lastname: Rico-Arroyo
authors.forename: Martín
authors.initials: M
authors.lastname: Becerril-Ngeles
mesh_terms: D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D006801:Humans; D015995:Prevalence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity