title: Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.
abstract: Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.
authors.affiliation: Department of Materials Science and Engineering, §Department of Veterinary Clinical Medicine, and ⊥Department of Bioengineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.forename: Felix Y
authors.initials: FY
authors.lastname: Yap
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Dobrucki
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Fan
authors.forename: Ron C
authors.initials: RC
authors.lastname: Gaba
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000138:chemical synthesis*; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000138:chemical synthesis*; D061986:MCF-7 Cells / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000138:chemical synthesis*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D011108:Polymers; D007472:Iohexol