title: Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.
abstract: Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton's jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.
authors.affiliation: The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust & ISTM, Keele University, Oswestry, Shropshire SY10 7AG, UK. claire.mennan@rjah.nhs.uk
authors.forename: Claire
authors.initials: C
authors.lastname: Mennan
authors.forename: Karina
authors.initials: K
authors.lastname: Wright
authors.forename: Atanu
authors.initials: A
authors.lastname: Bhattacharjee
authors.forename: Birender
authors.initials: B
authors.lastname: Balain
authors.forename: James
authors.initials: J
authors.lastname: Richardson
authors.forename: Sally
authors.initials: S
authors.lastname: Roberts
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D002469:Cell Separation / Q000379:methods*; D020219:Chondrogenesis; D004210:Dissection; D005434:Flow Cytometry; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D014470:Umbilical Cord / Q000098:blood supply / Q000166:cytology*