title: Host-guest chemistry of cyclodextrin carbamates and cellulose derivatives in aqueous solution.
abstract: Supramolecular polymer micelles were prepared on basis of the inclusion complexation between cyclodextrin carbamates and cellulose derivatives in aqueous media. Cyclodextrin carbamates were synthesized by microwave-assisted method from cyclodextrin and urea. The urea modified cyclodextrin shows the higher yield than the physical mixture of urea/cyclodextrin in the micellization with cellulose derivatives. The supramolecular structure of the core-shell micelles was demonstrated by (1)H NMR spectra, TEM images, and fluorescence spectra. The drug release behavior of the supramolecular polymer micelles was evaluated using prednisone acetate as a model drug. The drug loaded micelles showed steady and long time drug release behavior. With these properties, the supramolecular polymer micelles are attractive as drug carriers for pharmaceutical applications.
authors.affiliation: Department of Polymer Science, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Xiangxiang
authors.initials: X
authors.lastname: Jia
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Du
authors.forename: Longqiang
authors.initials: L
authors.lastname: Xiao
authors.forename: Feifei
authors.initials: F
authors.lastname: Li
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liao
authors.forename: Lijian
authors.initials: L
authors.lastname: Liu
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives*; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D055772:Green Chemistry Technology; D008823:Micelles; D008872:Microwaves; D011241:Prednisone / Q000737:chemistry; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D002219:Carbamates; D003505:Cyclodextrins; D004337:Drug Carriers; D008823:Micelles; D012996:Solutions; D014867:Water; D002482:Cellulose; D011241:Prednisone
keywords: Cellulose derivatives; Cyclodextrin carbamates; Host–guest chemistry; Self-assembly; Supramolecular polymer micelles