title: A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: an original study with meta-analysis.
abstract: The m.10398G>A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G>A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G>A polymorphism and breast cancer [OR = 0.916 (0.743-1.128); P = 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G>A substitution with breast cancer [OR = 1.016 (0.85-1.22); P = 0.86]. In conclusion, there is no evidence of association between m.10398G>A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk.
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: Amirtharaj
authors.initials: A
authors.lastname: Francis
authors.forename: Singh
authors.initials: S
authors.lastname: Pooja
authors.forename: Singh
authors.initials: S
authors.lastname: Rajender
authors.forename: Periyasamy
authors.initials: P
authors.lastname: Govindaraj
authors.forename: Nageswara Rao
authors.initials: NR
authors.lastname: Tipirisetti
authors.forename: Daminani
authors.initials: D
authors.lastname: Surekha
authors.forename: Digumarthi Raghunatha
authors.initials: DR
authors.lastname: Rao
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Rao
authors.forename: Lingadakai
authors.initials: L
authors.lastname: Ramachandra
authors.forename: Satti
authors.initials: S
authors.lastname: Vishnupriya
authors.forename: K
authors.initials: K
authors.lastname: Ramalingam
authors.forename: Kapaettu
authors.initials: K
authors.lastname: Satyamoorthy
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Thangaraj
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D007194:India
chemical_list: D004272:DNA, Mitochondrial
keywords: Breast cancer; Meta-analysis; m.10398A>G; mtDNA