title: Unlocking the biology of RAGE in diabetic microvascular complications.
abstract: The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for the elucidation of important mechanisms underpinning diabetic complications. RAGE transduces the signals of advanced glycation end-products (AGEs), proinflammatory S100/calgranulins, and high mobility group box 1 (HMGB1), and is a one of a family of receptors for lysophosphatidic acid (LPA). These ligand tales weave a theme of vascular perturbation and inflammation linked to the pathogenesis of the chronic complications of diabetes. Once deemed implausible, this concept of inflammatory cues participating in diabetic complications is now supported by a plethora of experimental evidence in the macro- and microvasculature. We review the biology of ligand-RAGE signal transduction and its roles in diabetic microvascular complications, from animal models to human subjects.
authors.affiliation: Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Michaele B
authors.initials: MB
authors.lastname: Manigrasso
authors.affiliation: Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Judyta
authors.initials: J
authors.lastname: Juranek
authors.affiliation: Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramasamy
authors.affiliation: Diabetes Research Program, Division of Endocrinology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: annmarie.schmidt@nyumc.org.
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D048909:Diabetes Complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D000080865:Formins; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D024243:HMGB1 Protein / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D007249:Inflammation / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002352:Carrier Proteins; C491464:Diap1 protein, mouse; D000080865:Formins; D017127:Glycation End Products, Advanced; D024243:HMGB1 Protein; D039841:Leukocyte L1 Antigen Complex; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
keywords: complications; diabetes; inflammation; ligands; receptor for AGE