title: One-pot total chemical synthesis of human α-synuclein.
abstract: Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Station 19, CH-1015 Lausanne, Switzerland. hilal.lashuel@epfl.ch.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fauvet
authors.forename: Sara M
authors.initials: SM
authors.lastname: Butterfield
authors.forename: Jonas
authors.initials: J
authors.lastname: Fuks
authors.forename: Ashraf
authors.initials: A
authors.lastname: Brik
authors.forename: Hilal A
authors.initials: HA
authors.lastname: Lashuel
mesh_terms: D002384:Catalysis; D006801:Humans; D010648:Phenylacetates / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D053778:Thiazolidines / Q000737:chemistry; D051844:alpha-Synuclein / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010648:Phenylacetates; D013438:Sulfhydryl Compounds; D053778:Thiazolidines; D051844:alpha-Synuclein; C456415:4-mercaptobenzeneacetic acid