title: Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman.
abstract: We report the case of a 19-year-old woman with progressive proliferative lupus nephritis (LN) class III after induction and maintenance therapy with mycophenolate mofetil (MMF). Despite a satisfying clinical improvement proteinuria progressed under this medication. We treated the patient with additional belimumab after discussing other options. Following treatment with belimumab, proteinuria rapidly improved to almost normal levels and clinical remission lasted. Belimumab might hold promise for this indication.
authors.affiliation: 1Department of Nephrology and Rheumatology, University Medicine Göttingen, Göttingen, Germany.
authors.forename: E E
authors.initials: EE
authors.lastname: Fließer
authors.forename: P
authors.initials: P
authors.lastname: Korsten
authors.forename: M J
authors.initials: MJ
authors.lastname: Koziolek
authors.forename: T B
authors.initials: TB
authors.lastname: Niewold
authors.forename: D
authors.initials: D
authors.lastname: Patschan
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: S A
authors.initials: SA
authors.lastname: Patschan
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008181:Lupus Nephritis / Q000188:drug therapy* / Q000503:physiopathology; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy / Q000209:etiology; D012074:Remission Induction; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; C511911:belimumab; D009173:Mycophenolic Acid
keywords: Proliferative lupus nephritis; belimumab; mycophenolate mofetil; systemic lupus erythematosus