title: Genetic deafness of central origin.
abstract: The autosomal recessive gene quivering in the mouse causes deafness. The cochlea in mutant animals is histologically normal, and the thresholds for compound action potentials at the round window are also normal. But the thresholds for potentials in the inferior colliculus are significantly higher in mutant animals than in normal ones, showing that the cause of deafness is retrocochlear. This mutant is believed to be the first proven instance of genetic deafness of central origin.
authors.affiliation: Department of Genetics and Biometry, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Deol
authors.forename: M P
authors.initials: MP
authors.lastname: Frank
authors.forename: K P
authors.initials: KP
authors.lastname: Steel
authors.forename: G R
authors.initials: GR
authors.lastname: Bock
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D003053:Cochlear Duct / Q000502:physiology; D003638:Deafness / Q000235:genetics* / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005808:Genes, Recessive; D007245:Inferior Colliculi / Q000503:physiopathology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D012405:Round Window, Ear / Q000502:physiology