title: Structure homology and interaction redundancy for discovering virus-host protein interactions.
abstract: Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
authors.affiliation: Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Laboratoire de virologie, 103 grande rue de la Croix-Rousse, Lyon, F-69004, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: de Chassey
authors.forename: Laurène
authors.initials: L
authors.lastname: Meyniel-Schicklin
authors.forename: Anne
authors.initials: A
authors.lastname: Aublin-Gex
authors.forename: Vincent
authors.initials: V
authors.lastname: Navratil
authors.forename: Thibaut
authors.initials: T
authors.lastname: Chantier
authors.forename: Patrice
authors.initials: P
authors.lastname: André
authors.forename: Vincent
authors.initials: V
authors.lastname: Lotteau
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D004285:Dogs; D054884:Host-Pathogen Interactions; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D008954:Models, Biological; D008969:Molecular Sequence Data; D009975:Orthomyxoviridae / Q000378:metabolism / Q000502:physiology; D011485:Protein Binding; D017361:Viral Nonstructural Proteins / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins