title: Pathophysiology of the brain extracellular matrix: a new target for remyelination.
abstract: The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to its normal physiology. Alterations to the ECM occur after neural injury (for example, in multiple sclerosis, spinal cord injury or Alzheimer's disease) and can have drastic consequences. Of note, injury-induced changes in chondroitin sulphate proteoglycans (CSPGs)--a family of ECM proteoglycans--can lead to the inhibition of myelin repair. Here, we highlight the pathophysiological roles of the brain's ECM, particularly those of CSPGs, after neural insults and discuss how the ECM can be targeted to promote remyelination.
authors.affiliation: 1] Hotchkiss Brain Institute and the Departments of Clinical Neurosciences and Oncology, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada. [2].
authors.forename: Lorraine W
authors.initials: LW
authors.lastname: Lau
authors.forename: Rowena
authors.initials: R
authors.lastname: Cua
authors.forename: Michael B
authors.initials: MB
authors.lastname: Keough
authors.forename: Sarah
authors.initials: S
authors.lastname: Haylock-Jacobs
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism; D003711:Demyelinating Diseases / Q000473:pathology* / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*
chemical_list: D011508:Chondroitin Sulfate Proteoglycans