title: First case of Mycobacterium longobardum infection.
abstract: Mycobacterium longobardum is a slow-growing, nontuberculous mycobacterium that was first characterized from the M. terrae complex in 2012. We report a case of M. longobardum induced chronic osteomyelitis. A 71-yr-old man presented with inflammation in the left elbow and he underwent a surgery under the suspicion of tuberculous osteomyelitis. The pathologic tissue culture grew M. longobardum which was identified by analysis of the 65-kDa heat shock protein and full-length 16S rRNA genes. The patient was cured with the medication of clarithromycin and ethambutol without further complications. To the best of our knowledge, this is the first report of a M. longobardum infection worldwide.
authors.affiliation: Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Sung Kuk
authors.initials: SK
authors.lastname: Hong
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Sung
authors.forename: Hyuk Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Myung-Don
authors.initials: MD
authors.lastname: Oh
authors.forename: Sung Sup
authors.initials: SS
authors.lastname: Park
authors.forename: Eui-Chong
authors.initials: EC
authors.lastname: Kim
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D018834:Chaperonin 60 / Q000235:genetics; D017291:Clarithromycin / Q000627:therapeutic use; D004550:Elbow / Q000473:pathology; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018834:Chaperonin 60; D012336:RNA, Ribosomal, 16S; C074119:heat-shock protein 65, Mycobacterium; D004977:Ethambutol; D017291:Clarithromycin
keywords: Mycobacterium longobardum; Nontuberculous mycobacteria; Osteomyelitis