title: Hunger hormone profile monitoring after gastroplication in an adolescent.
abstract: BACKGROUND
  Gut and adipose tissue hormones play an important role in energy balance control, particularly through the regulation at either short- or long-term food intake after bariatric surgery.
  
  
  METHODS
  A 15-year-old obese female (BMI 42.2) who was unresponsive to medical treatment underwent gastroplication. Hunger hormone levels (leptin, ghrelin and insulin), weight loss and eating behavior were monitored at 3, 6 and 12 months after surgery.
  
  
  RESULTS
  Weight loss was obtained, progressively achieving a loss of 45.6 kg 1 year after surgery. A strong reduction in insulin concentration and insulin resistance was documented. At 3 months after the operation, a surprising leptin level drop was observed. During the following months a progressive increase in leptin levels and leptin/kg of fat mass were documented. Fasting ghrelin levels increased in the first 3 months, then fell over the next 6 months. Up to 6 months after gastroplication, we observed a less marked drop in plasma ghrelin after meal ingestion, while the values after 1 year showed a substantial fall in the postprandial period despite a further fasting ghrelin increased level. Early achievement of satiety was found.
  
  
  CONCLUSIONS
  Hunger hormones level changes seem to be involved in weight loss and eating behavior after gastroplication in adolescents.
authors.affiliation: Pediatric Unit, Department of the Mother and Child Health, IRCCS Policlinico San Matteo Foundation Pavia, Pavia, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Calcaterra
authors.forename: Gloria
authors.initials: G
authors.lastname: Pelizzo
authors.forename: Ghassan
authors.initials: G
authors.lastname: Nakib
authors.forename: Daniela
authors.initials: D
authors.lastname: Larizza
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Fonte
authors.forename: Mara
authors.initials: M
authors.lastname: De Amici
authors.forename: Hellas
authors.initials: H
authors.lastname: Cena
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D013270:Stomach / Q000601:surgery*
chemical_list: D007328:Insulin; D020738:Leptin