title: Rifampicin-resistant Mycobacterium leprae in an elderly leprosy patient in the people's Republic of China.
abstract: The reported number of registered leprosy patients worldwide declined with the introduction of multidrug therapy. However, the emergence of rifampicin resistance in leprosy patients engenders difficulties for an individual patient, and its dissemination could pose a threat to leprosy control. This study reports an elderly patient who was diagnosed with rifampicin-resistant lepromatous leprosy. This case indicates that inadequate treatment and poor compliance may eventually result in rifampicin resistance in Mycobacterium leprae and clinical relapse.
authors.affiliation: Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for STD and Leprosy Control, China CDC, Nanjing, People's Republic of China.
authors.forename: Meiwen
authors.initials: M
authors.lastname: Yu
authors.forename: Kan
authors.initials: K
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Pei
authors.forename: Degang
authors.initials: D
authors.lastname: Yang
authors.forename: Qiulin
authors.initials: Q
authors.lastname: Wang
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Wang
authors.forename: Jianping
authors.initials: J
authors.lastname: Shen
authors.forename: Liangbing
authors.initials: L
authors.lastname: Yan
authors.forename: Guochen
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000368:Aged; D004352:Drug Resistance, Microbial / Q000187:drug effects; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy*; D008297:Male; D055118:Medication Adherence; D009166:Mycobacterium leprae / Q000187:drug effects*; D012293:Rifampin / Q000627:therapeutic use*; D013624:Taiwan
chemical_list: D007917:Leprostatic Agents; D012293:Rifampin
keywords: drug resistance; elderly patient; leprosy; rifampicin