title: Minimally invasive resin infiltration of arrested white-spot lesions: a randomized clinical trial.
abstract: BACKGROUND
  The authors conducted a randomized, single-masked clinical trial involving patients who had completed orthodontic treatment to assess changes in the appearance of white-spot lesions (WSLs) that were treated with resin infiltration.
  
  
  METHODS
  The authors divided affected teeth into control and treatment groups. In the treatment group, they restored teeth with WSLs by using resin infiltration. They evaluated changes in WSLs photographically by using a visual analog scale (VAS) (0 = no change, 100 = complete disappearance) and area measurements (in square millimeters). The authors analyzed the data by using two-way analysis of variance.
  
  
  RESULTS
  The mean VAS ratings for treated teeth demonstrated marked improvement relative to that for control teeth immediately after treatment (67.7 versus 5.2, P < .001) and eight weeks later (65.9 versus 9.2, P < .001). The results for treated teeth showed a mean reduction in WSL area of 61.8 percent immediately after treatment and 60.9 percent eight weeks later, compared with a -3.3 percent change for control teeth immediately after treatment and a 1.0 percent reduction eight weeks later.
  
  
  CONCLUSIONS
  Resin infiltration significantly improved the clinical appearance of WSLs, with stable results seen eight weeks after treatment.
  
  
  CONCLUSIONS
  Resin infiltration, a minimally invasive restorative treatment, was shown to be effective for WSLs that formed during orthodontic treatment.
authors.affiliation: Department of Orthodontics, School of Dentistry, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Seth V
authors.initials: SV
authors.lastname: Senestraro
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Crowe
authors.forename: Mansen
authors.initials: M
authors.lastname: Wang
authors.forename: Alex
authors.initials: A
authors.lastname: Vo
authors.forename: Greg
authors.initials: G
authors.lastname: Huang
authors.forename: Jack
authors.initials: J
authors.lastname: Ferracane
authors.forename: David A
authors.initials: DA
authors.lastname: Covell
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000293:Adolescent; D003731:Dental Caries / Q000473:pathology / Q000628:therapy*; D003764:Dental Materials / Q000737:chemistry*; D003793:Dental Restoration, Permanent / Q000379:methods; D004955:Esthetics, Dental; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006851:Hydrochloric Acid / Q000737:chemistry; D055115:Light-Curing of Dental Adhesives / Q000379:methods; D008297:Male; D023861:Photography, Dental; D012117:Resins, Synthetic / Q000737:chemistry*; D016037:Single-Blind Method; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D003764:Dental Materials; D012117:Resins, Synthetic; C578177:icon infiltrant; D006851:Hydrochloric Acid
keywords: Resin infiltration; demineralization; white-spot lesions