title: Propranolol as a treatment option in Gorham-Stout syndrome: a case report.
abstract: Gorham-Stout syndrome is a very rare syndrome characterized by progressive angiomatosis and lymphangiomas involving multiple organs. We describe herein a girl with progressive Gorham-Stout syndrome since the age of 13 years. Her disease involved the mediastinum, pericardium, vertebrae, ribs, and skull and did not respond to interferon and bisphosphonates. Propranolol administration was initiated at the age of 18 years and was associated with improvement in pulmonary function tests and involution of the mediastinal and hilar hemangiomatous lesions. The possible beneficial effect of propranolol in Gorham-Stout syndrome should be further investigated.
authors.affiliation: Pediatric Pulmonary Unit, Meyer Children's Hospital, Rambam Health Care Campus, Israel; Pediatric Department, Hillel Yaffe Medical Center, Hadera, Israel.
authors.forename: Vered
authors.initials: V
authors.lastname: Nir
authors.forename: Ludmila
authors.initials: L
authors.lastname: Guralnik
authors.forename: Galit
authors.initials: G
authors.lastname: Livnat
authors.forename: Ronen
authors.initials: R
authors.lastname: Bar-Yoseph
authors.forename: Fahed
authors.initials: F
authors.lastname: Hakim
authors.forename: Anat
authors.initials: A
authors.lastname: Ilivitzki
authors.forename: Lea
authors.initials: L
authors.lastname: Bentur
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D010015:Osteolysis, Essential / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*
chemical_list: D011433:Propranolol
keywords: Gorham-Stout syndrome; propranolol