title: Caspases and their role in gastric cancer.
abstract: Caspases (Cysteine Aspartate Specific Proteases) are a group of cysteine-containing proteolytic enzymes produced by the cells of living organisms. They participate in immunological functions, proliferation, cell migration and organization. Caspases also influence the secretion of various regulative factors. Moreover, they are responsible for cellular maturation and reconstruction, and for regulating the number and quality of cells initiating the apoptosis of old cells or those that cannot play their normal role due to abnormalities. Multiple pathological processes are associated with disorders in the activity of caspases. Changes in expression of individual caspases have been observed in gastric cancer. The expression of some caspases is also correlated with particular histological traits and the frequency of metastases, which suggests their possible use as a prognostic factor. It has also been discovered that some somatic mutations in caspase coding genes might lead to inhibition of apoptosis and the progression of the disease. Gene polymorphism may be a gastric cancer risk factor, but may also play a protective function. Considering the less than satisfactory effects of conventional therapeutic methods, the search for alternative ways to activate apoptosis - through gene therapy or selective activation of individual elements of the apoptotic pathways - constitutes a promising direction for studies of new therapeutic strategies. Caspases, enzymes playing a central role in the process of programmed cellular death, may possibly be a key to the development of a more effective anti-cancer therapy.
authors.affiliation: 2nd Department of General and Oncological Surgery, Wroclaw Medical University Hospital, Wrocław, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Frejlich
authors.forename: Julia
authors.initials: J
authors.lastname: Rudno-Rudzińska
authors.forename: Kacper
authors.initials: K
authors.lastname: Janiszewski
authors.forename: Lukasz
authors.initials: L
authors.lastname: Salomon
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kotulski
authors.forename: Oskar
authors.initials: O
authors.lastname: Pelzer
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Grzebieniak
authors.forename: Robert
authors.initials: R
authors.lastname: Tarnawa
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kielan
mesh_terms: D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000628:therapy
chemical_list: D020169:Caspases