title: Recurrent fevers and failure to thrive in an infant.
abstract: We describe a 2-year old boy with consanguineous parents who recently emigrated from India and presented with oral ulcers and lymphadenopathy. He also had a history of recurrent fevers, polyarticular arthritis, chronic diarrhea, failure to thrive, and developmental delay. Infectious workup revealed herpes simplex virus 1 viremia and radiological evaluation revealed osteopenia and erosions involving multiple joints. We describe the immunologic and genetic evaluation of this patient and discuss the diagnostic and therapeutic approach to an infant with recurrent fevers.
authors.affiliation: Scripps Clinic, Department of Medicine, San Diego, CA 92130, USA. deardrscott@gmail.com
authors.forename: David R
authors.initials: DR
authors.lastname: Scott
authors.forename: Sarah
authors.initials: S
authors.lastname: Chan
authors.forename: Johanna
authors.initials: J
authors.lastname: Chang
authors.forename: Lori
authors.initials: L
authors.lastname: Broderick
authors.forename: Hal M
authors.initials: HM
authors.lastname: Hoffman
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001175:Arthrography; D002675:Child, Preschool; D003241:Consanguinity; D004252:DNA Mutational Analysis; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D005183:Failure to Thrive / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005334:Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000008:administration & dosage; D017880:Limb Deformities, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics / Q000378:metabolism*; D012008:Recurrence
chemical_list: D000893:Anti-Inflammatory Agents; D004279:DNA, Viral; D053590:Interleukin 1 Receptor Antagonist Protein; D017853:Phosphotransferases (Alcohol Group Acceptor); C021796:mevalonate kinase