title: Serum adiponectin and type 2 diabetes: a 6-year follow-up cohort study.
abstract: BACKGROUND
  Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.
  
  
  METHODS
  A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.
  
  
  RESULTS
  Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.
  
  
  CONCLUSIONS
  A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.
authors.affiliation: Institute for Health Promotion, Department of Epidemiology and Health Promotion, Yonsei University Graduate School of Public Health, Seoul, Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.forename: Hyon-Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang-Hak
authors.initials: SH
authors.lastname: Lee
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Myoungsook
authors.initials: M
authors.lastname: Lee
authors.forename: Chang Beom
authors.initials: CB
authors.lastname: Lee
authors.forename: Hye Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Heejin
authors.initials: H
authors.lastname: Kimm
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Jidong
authors.initials: J
authors.lastname: Sung
authors.forename: Seungjoon
authors.initials: S
authors.lastname: Oh
authors.forename: Hyojee
authors.initials: H
authors.lastname: Joung
authors.forename: Sung Rae
authors.initials: SR
authors.lastname: Kim
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Kim
authors.forename: Hong Soo
authors.initials: HS
authors.lastname: Lee
authors.forename: Yejin
authors.initials: Y
authors.lastname: Mok
authors.forename: Eunmi
authors.initials: E
authors.lastname: Choi
authors.forename: Young Duk
authors.initials: YD
authors.lastname: Yun
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Baek
authors.forename: Jaeseong
authors.initials: J
authors.lastname: Jo
authors.forename: Kap Bum
authors.initials: KB
authors.lastname: Huh
keywords: Adiponectin; Cohort studies; Diabetes mellitus; Impaired fasting glucose