title: Autoantigens and autoantibodies in multiple sclerosis.
abstract: Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory T helper (Th)1 and Th17 phenotypes, macrophages, and soluble inflammatory mediators. The overactive pro-inflammatory Th1 cells and clonal expansion of B cells initiate an inflammatory cascade with several cellular and molecular immune components participating in MS pathogenic mechanisms. In this scenario, autoantibodies and autoantigens have a significant role in immunopathogenesis, diagnosis and therapeutic targets of MS. In this review, we try to introduce the autoantigens and autoantibodies and explain their roles in pathogenesis of MS.
authors.affiliation: Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. mirshafiey@tums.ac.ir.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
authors.forename: Mahsa
authors.initials: M
authors.lastname: Kianiaslani
mesh_terms: D051401:Aquaporin 4 / Q000276:immunology; D019390:Arrestins / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D038203:alpha-Crystallin B Chain / Q000276:immunology; D000071557:beta-Arrestins
chemical_list: D051401:Aquaporin 4; D019390:Arrestins; D001323:Autoantibodies; D001324:Autoantigens; C571326:MOG protein, human; D063308:Myelin-Oligodendrocyte Glycoprotein; D038203:alpha-Crystallin B Chain; D000071557:beta-Arrestins; D010751:Phosphopyruvate Hydratase