title: [Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix].
abstract: To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups: RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.
authors.affiliation: The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China. xingrong9796@163.com
authors.forename: Rong
authors.initials: R
authors.lastname: Xing
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Song
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D027883:Astragalus Plant / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D011799:Quinazolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013876:Thiophenes / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D011799:Quinazolines; D013876:Thiophenes; C068874:raltitrexed