title: Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes.
abstract: We present the first experimental results of reflectance Diffuse Optical Tomography (DOT) performed with a fast-gated single-photon avalanche diode (SPAD) coupled to a time-correlated single-photon counting system. The Mellin-Laplace transform was employed to process time-resolved data. We compare the performances of the SPAD operated in the gated mode vs. the non-gated mode for the detection and localization of an absorbing inclusion deeply embedded in a turbid medium for 5 and 15 mm interfiber distances. We demonstrate that, for a given acquisition time, the gated mode enables the detection and better localization of deeper absorbing inclusions than the non-gated mode. These results obtained on phantoms demonstrate the efficacy of time-resolved DOT at small interfiber distances. By achieving depth sensitivity with limited acquisition times, the gated mode increases the relevance of reflectance DOT at small interfiber distance for clinical applications.
authors.affiliation: CEA-LETI, Minatec Campus, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Puszka
authors.forename: Laura
authors.initials: L
authors.lastname: Di Sieno
authors.forename: Alberto Dalla
authors.initials: AD
authors.lastname: Mora
authors.forename: Antonio
authors.initials: A
authors.lastname: Pifferi
authors.forename: Davide
authors.initials: D
authors.lastname: Contini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Boso
authors.forename: Alberto
authors.initials: A
authors.lastname: Tosi
authors.forename: Lionel
authors.initials: L
authors.lastname: Hervé
authors.forename: Anne
authors.initials: A
authors.lastname: Planat-Chrétien
authors.forename: Anne
authors.initials: A
authors.lastname: Koenig
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
keywords: (030.5260) Photon counting; (170.3010) Image reconstruction techniques; (170.6920) Time-resolved imaging; (170.6960) Tomography; (170.7050) Turbid media; (230.5170) Photodiodes