title: Lung cancer biomarkers: present status and future developments.
abstract: The publication of the "Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology" has now provided a guideline for biomarker testing for first-generation lung cancer tyrosine kinase inhibitors. Biomarker testing has forever altered the role of pathologists in the management of patients with lung cancer. Current, unresolved issues in the precision medicine of lung cancer will be addressed by the development of new biomarker tests, new drugs, and new test technologies and by improvement in the cost to benefit ratio of biomarker testing.
authors.affiliation: Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA. pcagle@tmhs.org
authors.forename: Philip T
authors.initials: PT
authors.lastname: Cagle
authors.forename: Timothy Craig
authors.initials: TC
authors.lastname: Allen
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Olsen
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D058990:Molecular Targeted Therapy; D057089:Pathology, Molecular / Q000191:economics / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor