title: Clinical significance of serum angiopoietin-1 in malignant peritoneal mesothelioma.
abstract: We have previously reported that angiopoietin-1 was correlated with pulmonary fibrosis. Here, we investigated the serum levels of angiopoietin-1 in patients with malignant peritoneal mesothelioma, which originate from mesenchymal cells similar to lung fibroblasts. We showed that patients with peritoneal mesothelioma had significantly higher serum levels of angiopoietin-1 in comparison with a population with a history of asbestos exposure without peritoneal mesothelioma, and the Kaplan-Meier method revealed a significant correlation between serum angiopoietin-1 levels and survival. This is the first report about the relationship between angiopoietin-1 and peritoneal mesothelioma.
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine,1.
authors.forename: Koji
authors.initials: K
authors.lastname: Mikami
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nogi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Terada
authors.forename: Miki
authors.initials: M
authors.lastname: Honda
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kamiya
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nishizaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D042683:Angiopoietin-1 / Q000097:blood*; D001194:Asbestos / Q000633:toxicity; D001195:Asbestosis / Q000097:blood; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D011658:Pulmonary Fibrosis / Q000150:complications; D013534:Survival
chemical_list: D042683:Angiopoietin-1; D001194:Asbestos