title: PRC2 goes solo in the Drosophila female germline.
abstract: Polycomb-group proteins silence gene expression through epigenetic modification of chromatin. In this issue of Developmental Cell, Iovino et al. (2013) demonstrate that Polycomb repressive complex 2 (PRC2) is required for maintenance of oocyte fate by repressing expression of two critical targets, Cyclin E and dacapo, during the early meiotic cycle.
authors.affiliation: Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. jkassis@mail.nih.gov
authors.forename: Judith A
authors.initials: JA
authors.lastname: Kassis
authors.forename: Mary A
authors.initials: MA
authors.lastname: Lilly
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000235:genetics*; D005260:Female; D018816:Genes, cdc; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D009865:Oocytes / Q000166:cytology*; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D012097:Repressor Proteins; D011495:Histone-Lysine N-Methyltransferase; C524066:PRC2 protein, Drosophila