title: [Relationship between Spred1 and acute myeloid leukemia].
abstract: SPRED1 protein coded by SPRED1 gene, a kind of tumors suppressor, belongs to Sprouty related protein family and mainly distributes in human brain. The activity of SPRED1 is mainly regulated by the tyrosine phosphorylation, which is stimulated by the hemopoietic factors. As an inhibitor of Ras-MAPK and RhoA cell signaling pathways, SPRED1 plays an important role in tumorigenesis and metastasis of solid tumor. Recently, the inactivation of SPRED1 is reported to result in proliferation, survival time extension and induction angiogenesis of AML cells. There is a clue that SPRED1 is highly related to leukemia genesis. Recently our study proved that the expression level of SPRED1 decreased in patients with acute myeloid leukemia (AML). This review summarizes the recent progress of study on the relationship between SPRED1 and AML, so as to explore the pathogenesis of leukemia and provide a new approach for clinical diagnosis.
authors.affiliation: Deprtment of Hematology, The First Affiliated Hospilal, China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology*; D008565:Membrane Proteins / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D015398:Signal Transduction; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D012097:Repressor Proteins; C504812:SPRED1 protein, human; D020742:rhoA GTP-Binding Protein