title: Genetic variants at 20p11 confer risk to androgenetic alopecia in the Chinese Han population.
abstract: BACKGROUND
  Androgenetic alopecia (AGA) is a well-characterized type of progressive hair loss commonly seen in men, with different prevalences in different ethnic populations. It is generally considered to be a polygenic heritable trait. Several susceptibility genes/loci, such as AR/EDA2R, HDAC9 and 20p11, have been identified as being involved in its development in European populations. In this study, we aim to validate whether these loci are also associated with AGA in the Chinese Han population.
  
  
  METHODS
  We genotyped 16 previously reported single nucleotide polymorphisms (SNPs) with 445 AGA cases and 546 healthy controls using the Sequenom iPlex platform. The trend test was used to evaluate the association between these loci and AGA in the Chinese Han population. Conservatively accounting for multiple testing by the Bonferroni correction, the threshold for statistical significance was P ≤ 3.13 × 10(-3).
  
  
  RESULTS
  We identified that 5 SNPs at 20p11 were significantly associated with AGA in the Chinese Han population (1.84 × 10(-11) ≤ P ≤ 2.10 × 10(-6)).
  
  
  CONCLUSIONS
  This study validated, for the first time, that 20p11 also confers risk for AGA in the Chinese Han population and implicated the potential common genetic factors for AGA shared by both Chinese and European populations.
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China ; Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China ; State key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Chunjun
authors.initials: C
authors.lastname: Yang
authors.forename: Xianbo
authors.initials: X
authors.lastname: Zuo
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Yantao
authors.initials: Y
authors.lastname: Ding
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sheng
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Cheng
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Xuhui
authors.initials: X
authors.lastname: Fu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.forename: Dawei
authors.initials: D
authors.lastname: Duan
authors.forename: Xianfa
authors.initials: X
authors.lastname: Tang
authors.forename: Huayang
authors.initials: H
authors.lastname: Tang
authors.forename: Jinping
authors.initials: J
authors.lastname: Gao
authors.forename: Liangdan
authors.initials: L
authors.lastname: Sun
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000505:Alopecia / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006655:Histone Deacetylases / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011944:Receptors, Androgen / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D012307:Risk Factors; D053340:Xedar Receptor / Q000235:genetics; D055815:Young Adult
chemical_list: C410798:AR protein, human; C506011:EDA2R protein, human; D011944:Receptors, Androgen; D012097:Repressor Proteins; D053340:Xedar Receptor; C486544:HDAC9 protein, human; D006655:Histone Deacetylases