title: Biotransformation of ginsenoside Rd in the ginseng extraction residue by fermentation with lingzhi (Ganoderma lucidum).
abstract: Ginseng and lingzhi (Ganoderma lucidum) both are valuable traditional Chinese medicines and have been extensively utilised in functional foods and traditional medicines in many Asian countries. However, massive quantity of ginseng residue is produced after extraction of ginseng which still contains a lot of bioactive compounds such as ginsenosides. The goal of this study was to reuse the American ginseng extraction residue as the fermentation medium of G. lucidum to produce bioactive ginsenoside enriched biotransformation products. The changes of ginsenosides in the fermentation products were analysed during fermentation. Our results showed that after 30 days of fermentation, ginsenoside Rg1, Rd, and compound K (CK) significantly increased, especially Rd, while other ginsenosides (Re, Rb1 and Rc) decreased during fermentation. Ginsenoside Rd is the major ginsenoside in the final fermentation product. Furthermore, the biotransformation of ginsenosides was the major reaction in this fermentation process.
authors.affiliation: Graduate Institute of Food Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan.
authors.forename: Bo Yang
authors.initials: BY
authors.lastname: Hsu
authors.forename: Ting Jang
authors.initials: TJ
authors.lastname: Lu
authors.forename: Chia Hui
authors.initials: CH
authors.lastname: Chen
authors.forename: Shing Jung
authors.initials: SJ
authors.lastname: Wang
authors.forename: Lucy Sun
authors.initials: LS
authors.lastname: Hwang
mesh_terms: D001711:Biotransformation; D005285:Fermentation; D036145:Ginsenosides / Q000378:metabolism*; D005894:Panax / Q000378:metabolism* / Q000382:microbiology*; D020940:Reishi / Q000378:metabolism*
chemical_list: D036145:Ginsenosides; C049863:ginsenoside Rd
keywords: Biotransformation; Ganoderma lucidum; Ginseng; Ginsenoside; Lingzhi