title: Leukotriene B4, an endogenous stimulator of the innate immune response against pathogens.
abstract: Leukotriene B4 (LTB4) is an endogenous lipid mediator of inflammation derived from arachidonic acid by the sequential action of cytosolic phospholipase A2 and 5-lipoxygenase. This mediator was initially recognized for its involvement in the recruitment of neutrophils. However, in the last decade, LTB4 has been clearly demonstrated to play a significant role in the control of microbial infections through its ability to activate host innate defenses. In this review, we will focus on the modulator effects of LTB4 on the innate defenses and discuss its therapeutic potential against viral pathogens.
authors.affiliation: Laboratory of Innate Immunology, Centre Hospitalier Universitaire de Québec, and Department of Molecular Medicine, Laval University, Quebec City, Que., Canada.
authors.forename: Manon
authors.initials: M
authors.lastname: Le Bel
authors.forename: Alexandre
authors.initials: A
authors.lastname: Brunet
authors.forename: Jean
authors.initials: J
authors.lastname: Gosselin
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D007975:Leukotriene B4 / Q000276:immunology*; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
chemical_list: D018836:Inflammation Mediators; D051193:Toll-Like Receptors; D007975:Leukotriene B4