title: HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
abstract: Papillomavirus is the etiological agent for warts and several squamous carcinomas. Skin cancer induced by cottontail rabbit papillomavirus was the first animal model for virus-induced carcinogenesis. The target organ of the virus infection is stratified epithelium and virus replication is tightly regulated by the differentiation program of the host cell. E1^E4 protein is a viral gene product, and although it is considered to be involved in the control of virus replication, little is known about the biological role. We found that HPV18 E1^E4 was assembled into an aggresome-like compartment and was involved in sequestration of virus oncoproteins, which might contribute to the differentiation-dependent lifecycle of papillomavirus.
authors.affiliation: Laboratory of Mammalian Molecular Biology, Department of Molecular and Cellular Biology, Graduate School of Biostudies, Kyoto University Kyoto, Japan ; Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research, Kyoto University Kyoto, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kajitani
authors.forename: Ayano
authors.initials: A
authors.lastname: Satsuka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakai
keywords: E1^E4; HPV; HPV oncoproteins; HPV replication; aggresome