title: Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine.
abstract: Long-term potentiation (LTP) of CA1 population spikes was elicited by cCA3 stimulation. Phencyclidine (PCP) and ketamine blocked the potentiation in a dose-dependent manner while diazepam and sodium thiopental had no effect. In midcollicular-transected rats where PCP has no depressant effect on the population spike, the drug still blocked LTP.
authors.affiliation: University of Virginia School of Medicine, Department of Pharmacology, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Stringer
authors.forename: P G
authors.initials: PG
authors.lastname: Guyenet
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000502:physiology; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013874:Thiopental / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018757:GABA Modulators; D007649:Ketamine; D010622:Phencyclidine; D013874:Thiopental; D003975:Diazepam