title: Acremonium sclerotigenum-Acremonium egyptiacum: a multi-resistant fungal pathogen complicating the course of aplastic anaemia.
abstract: A patient with aplastic anaemia, successively treated with caspofungin then liposomal amphotericin, developed a disseminated infection due to Acremonium, further confirmed as resistant in vitro to these drugs. Successful treatment was achieved with voriconazole. Multiple antifungal treatments may expose to the risk of breakthrough of multi-resistant pathogens in haematology patients.
authors.affiliation: Department of Parasitology and Mycology, Saint-Antoine Hospital, AP-HP, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guitard
authors.forename: A
authors.initials: A
authors.lastname: Degulys
authors.forename: G
authors.initials: G
authors.lastname: Buot
authors.forename: A
authors.initials: A
authors.lastname: Aline-Fardin
authors.forename: E
authors.initials: E
authors.lastname: Dannaoui
authors.forename: B
authors.initials: B
authors.lastname: Rio
authors.forename: J P
authors.initials: JP
authors.lastname: Marie
authors.forename: S
authors.initials: S
authors.lastname: Lapusan
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
mesh_terms: D000164:Acremonium / Q000145:classification / Q000302:isolation & purification*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000741:Anemia, Aplastic / Q000150:complications* / Q000382:microbiology; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D025141:Drug Resistance, Fungal / Q000187:drug effects; D054714:Echinocandins / Q000627:therapeutic use*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D000077336:Caspofungin; D065819:Voriconazole
keywords: Acremonium; amphotericin B resistance; caspofungin resistance; opportunistic infections; severe aplastic anaemia