title: Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
abstract: OBJECTIVE
  Anastomotic leakage is a serious complication of gastrointestinal surgery resulting in increased morbidity and mortality, poor function and predisposing to cancer recurrence. Earlier diagnosis and intervention can minimize systemic complications but is hindered by current diagnostic methods that are non-specific and often uninformative. The purpose of this paper is to review current developments in the field and to identify strategies for early detection and treatment of anastomotic leakage.
  
  
  METHODS
  A systematic literature search was performed using the MEDLINE, Embase, PubMed and Cochrane Library databases. Search terms included 'anastomosis' and 'leak' and 'diagnosis' or 'detection' and 'gastrointestinal' or 'colorectal'. Papers concentrating on the diagnosis of gastrointestinal anastomotic leak were identified and further searches were performed by cross-referencing.
  
  
  RESULTS
  Computerized tomography CT scanning and water-soluble contrast studies are the current preferred techniques for diagnosing anastomotic leakage but suffer from variable sensitivity and specificity, have logistical constraints and may delay timely intervention. Intra-operative endoscopy and imaging may offer certain advantages, but the ability to predict anastomotic leakage is unproven. Newer techniques involve measurement of biomarkers for anastomotic leakage and have the potential advantage of providing cheap real-time monitoring for postoperative complications.
  
  
  CONCLUSIONS
  Current diagnostic tests often fail to diagnose anastomotic leak at an early stage that enables timely intervention and minimizes serious morbidity and mortality. Emerging technologies, based on detection of local biomarkers, have achieved proof of concept status but require further evaluation to determine whether they translate into improved patient outcomes. Further research is needed to address this important, yet relatively unrecognized, area of unmet clinical need.
authors.affiliation: Section of Translational Anaesthesia and Surgical Sciences, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Hirst
authors.forename: J P
authors.initials: JP
authors.lastname: Tiernan
authors.forename: P A
authors.initials: PA
authors.lastname: Millner
authors.forename: D G
authors.initials: DG
authors.lastname: Jayne
mesh_terms: D057868:Anastomotic Leak / Q000175:diagnosis*; D003287:Contrast Media; D013505:Digestive System Surgical Procedures; D004724:Endoscopy; D006801:Humans; D007432:Intraoperative Period; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: Colorectal surgery; anastomotic leak; biomarkers; diagnosis/detection