title: Cytotoxic constituents from the stems of Clausena lansium (Lour.) Skeels.
abstract: Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4-6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC₅₀ values of 6.19 to 26.84 μg/mL.
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning, China.
authors.forename: Hai Yan
authors.initials: HY
authors.lastname: Jiang
authors.forename: Cheng Fang
authors.initials: CF
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Jiang Bin
authors.initials: JB
authors.lastname: Feng
authors.forename: Zhu Feng
authors.initials: ZF
authors.lastname: Geng
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Zhi Wei
authors.initials: ZW
authors.lastname: Deng
authors.forename: Shu Shan
authors.initials: SS
authors.lastname: Du
authors.forename: Hai Bo
authors.initials: HB
authors.lastname: Yin
mesh_terms: D000447:Aldehydes / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000302:isolation & purification / Q000494:pharmacology*; D054700:Clausena / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*
chemical_list: C587023:2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde; C587024:8-geranyloxypsolaren; D000447:Aldehydes; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D004317:Doxorubicin