title: A role for angiopoietin-2 in organ-specific metastasis.
abstract: Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al. show that the calcineurin-NFAT pathway promotes pulmonary tumor metastasis by inducing ANG2 in the lung endothelium.
authors.affiliation: The Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Swiss Federal Institute of Technology Lausanne EPFL, 1015 Lausanne, Switzerland.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Rigamonti
authors.forename: Michele
authors.initials: M
authors.lastname: De Palma
mesh_terms: D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D050778:NFATC Transcription Factors / Q000378:metabolism*; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*
chemical_list: D050778:NFATC Transcription Factors; C099439:Ang2 protein, mouse; D012259:Ribonuclease, Pancreatic; D019703:Calcineurin