title: [Cytokinis and regulatory peptides: age-related changes, atherosclerosis and trombotic diseases].
abstract: The review contains different aspects indicating the participation of cytokines in aging-associated diseases. Authors reveal the role of short peptides in molecular mechanisms of homeostatic regulation in immune, cardiovascular, haemostatic systems which is based on the literature data and own experimental data. It is established that short peptides realize their geroprotective effect by changing gene expression of immune and proinflammatory cytokines and g-interferon.
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaia
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006487:Hemostasis / Q000235:genetics; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007107:Immune System / Q000502:physiology*; D010455:Peptides / Q000235:genetics* / Q000378:metabolism; D013927:Thrombosis / Q000235:genetics* / Q000378:metabolism
chemical_list: D016207:Cytokines; D010455:Peptides