title: [Chronobiological parameters, cognitive emotional status and sleep quality in acute stroke].
abstract: The night urinary level of 6-sulfatoxymelatonin was assessed in 57 patients in acute ischemic stroke and subarachnoid hemorrhage. The relationship between 6-sulfatoxymelatonin (6-SOMT) and chronobiological parameters, cognitive and emotional status and sleep quality was analyzed. The low levels of 6-SOMT in night urine was revealed and more pronounced in ischemic stroke. The association between low levels of 6-SOMT and domen-specific cognitive impairment, high level of trait anxiety and low sleep quality was found. The deficiency of chronotropic and neuroprotective activity of melatonin may be regarded as a key factor in the development of these pathological phenomena.
authors.forename: A A
authors.initials: AA
authors.lastname: Kulesh
authors.forename: V V
authors.initials: VV
authors.lastname: Shestakov
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D004644:Emotions / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*; D020521:Stroke / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D011795:Surveys and Questionnaires