title: Preattentive mechanisms of change detection in early auditory cortex: a 7 Tesla fMRI study.
abstract: The auditory system continuously monitors the environment for irregularities in an automatic, preattentive fashion. This is presumably accomplished by two mechanisms: a sensory mechanism detects a deviant sound on the basis of differential refractoriness of neural populations sensitive to the standard and deviant sounds, whereas the cognitive mechanism reveals deviance by comparing incoming auditory information with a template derived from previous input. Using fast event-related high-resolution functional magnetic resonance imaging at 7 Tesla we show that both mechanisms can be mapped to different parts of the auditory cortex both at the group level and the single-subject level. The sensory mechanism is supported by primary auditory areas in Heschl's gyrus whereas the cognitive mechanism is implemented in more anterior secondary auditory areas. Both mechanisms are equally engaged by simple sine-wave tones and speech-related phonemes indicating that streams of speech and non-speech stimuli are processed in a similar fashion.
authors.affiliation: Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Germany.
authors.forename: G R
authors.initials: GR
authors.lastname: Szycik
authors.forename: J
authors.initials: J
authors.lastname: Stadler
authors.forename: A
authors.initials: A
authors.lastname: Brechmann
authors.forename: T F
authors.initials: TF
authors.lastname: Münte
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology*; D001303:Auditory Cortex / Q000098:blood supply*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen; D011571:Psychoacoustics; D017603:Signal Detection, Psychological / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: 7Tesla; ANOVA; EEG; FDR; GLM; HG; Heschl’s gyrus; ISI; MEG; MMN; analysis of variance; auditory system; change detection; electroencephalography; fMRI; false discovery rate; functional magnetic resonance imaging; general linear model; interstimulus intervals; magnetoencephalography; mismatch negativity; refractoriness; speech