title: [Effect of cucurmosin on chronic myeloid leukemia K562 cell line].
abstract: This study was aimed to investigate the antitumor effect of pumpkin protein (cucurmosin, CUS) on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model. The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established; using two models, the antitumor activity of CUS in mice was evaluated. The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively; survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8 ± 5.5 d and 43.4 ± 6.6 d, antitumor rate was 24.9% and 36% respectively. It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562.
authors.affiliation: Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China (E-mail: liutb@medmail.com).
authors.forename: Ting-Bo
authors.initials: TB
authors.lastname: Liu
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Jie-Ming
authors.initials: JM
authors.lastname: Xie
authors.forename: Jian-Da
authors.initials: JD
authors.lastname: Hu
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010940:Plant Proteins / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D010940:Plant Proteins; C412450:cucurmosin protein, Cucurbita moschata