title: [A case of α-fetoprotein-producing hepatoid adenocarcinoma of the stomach with spontaneous rupture of multiple liver metastases].
abstract: An 85-year-old man with epigastric pain and anorexia was admitted to our hospital. His serum α-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist II (PIVKA II) levels were markedly elevated. Gastrointestinal endoscopy revealed a large mass near the fundus, and computed tomography revealed multiple liver tumors. Intraperitoneal bleeding followed rupture of a liver tumor and was successfully stopped by transarterial embolization; however, regrowth of multiple tumors followed, resulting in liver failure and death within a short period. Autopsy revealed hepatoid adenocarcinomas originating in the stomach that had metastasized to the liver. Hepatoid adenocarcinomas are hypervascular, rapidly growing tumors that may result in the spontaneous rupture of metastatic liver lesions. Transarterial embolization may be a feasible option for the treatment of these ruptured tumors.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takeda
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanesaka
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Matsuda
authors.forename: Azusa
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hatamaru
authors.forename: Sumio
authors.initials: S
authors.lastname: Saito
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nasu
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Komekado
authors.forename: Akira
authors.initials: A
authors.lastname: Sekikawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tsumura
authors.forename: Takanori
authors.initials: T
authors.lastname: Maruo
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okabe
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Osaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000369:Aged, 80 and over; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D012422:Rupture, Spontaneous; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins