title: Effect of sodium alginate on dextran sulfate sodium- and 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis in mice.
abstract: We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. In a separated study, colitis was induced by intrarectally administered TNBS. AL-Na, 5-aminosalicylic acid, or prednisolone was orally administered. These colitis models exhibited colonic damage and produced noticeable inflammatory responses and aggravated goblet cell damage. AL-Na significantly ameliorated DSS- and TNBS-induced experimental colitis and prevented goblet cell damage. Prednisolone also suppressed colitis but caused loss of body and spleen weight. In contrast, AL-Na did not provoke these symptoms. These data suggest that AL-Na may be a possible therapeutic agent for the treatment of inflammatory bowel disease.
authors.affiliation: Pharmaceutical Research Laboratories, Sakai Chemical Industry Co., Ltd., Kawachinagano, Osaka, Japan.
authors.forename: Atsuki
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Itoh
authors.forename: Reishi
authors.initials: R
authors.lastname: Nasu
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nishida
mesh_terms: D000464:Alginates / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000378:metabolism / Q000473:pathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D020723:Glucuronic Acid / Q000494:pharmacology / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000685:Serum Amyloid A Protein / Q000378:metabolism; D014301:Trinitrobenzenes
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020011:Protective Agents; D000685:Serum Amyloid A Protein; D014301:Trinitrobenzenes; C029222:sym-trinitrobenzene; D020723:Glucuronic Acid; D016264:Dextran Sulfate; D009195:Peroxidase