title: Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407.
abstract: The aim of this investigation was to develop a novel in situ gelling formulation based on poloxamer-407 (PM) for the sustained release of an ophthalmic drug. In an attempt to reduce the concentration of PM without compromising the in situ gelling capability and also to increase the drug release time, xanthan gum (XG) and guar gum (GG) were added into PM to develop different formulations. At concentrations of 18% and above, the PM was able to undergo sol-gel transition below body temperature. It was found that XG and GG at a weight ratio of 3:7 were able to convert PM solution into gel below body temperature at PM concentrations below 18%. Both the in vitro and in vivo studies indicated that the PM with an XG-GG combination had a better ability to retain the drug than PM itself. The results indicated that the developed in situ gelling formulations containing PM with XG-GG may be a better alternative than a conventional eye drop.
authors.affiliation: Himalayan Pharmacy Institute, Sikkim University, Majhitar, Rangpo, East Sikkim 737136, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Bhowmik
authors.forename: Puja
authors.initials: P
authors.lastname: Kumari
authors.forename: Gunjan
authors.initials: G
authors.lastname: Sarkar
authors.forename: Mrinal Kanti
authors.initials: MK
authors.lastname: Bain
authors.forename: Biplab
authors.initials: B
authors.lastname: Bhowmick
authors.forename: Md Masud Rahaman
authors.initials: MM
authors.lastname: Mollick
authors.forename: Dibyendu
authors.initials: D
authors.lastname: Mondal
authors.forename: Dipanwita
authors.initials: D
authors.lastname: Maity
authors.forename: Dipak
authors.initials: D
authors.lastname: Rana
authors.forename: Debashis
authors.initials: D
authors.lastname: Bhattacharjee
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005685:Galactans / Q000737:chemistry*; D005782:Gels; D008351:Mannans / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012212:Rheology; D013696:Temperature; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D005685:Galactans; D005782:Gels; D008351:Mannans; D009883:Ophthalmic Solutions; D053149:Plant Gums; D011135:Polysaccharides, Bacterial; D020442:Poloxamer; C007894:guar gum; C002563:xanthan gum
keywords: In vitro and in vivo studies; Poloxamer-407 based formulations; Sustained drug delivery