title: Molecular survey of knockdown resistance to pyrethroids in human scabies mites.
abstract: There are growing concerns about the emergence of resistance of Sarcoptes scabiei to permethrin and other pyrethroid derivatives. Sarcoptes scabiei mites collected from 40 patients visiting two hospitals near Paris, France, were genotypically characterized considering two parts of their voltage-sensitive sodium channel gene. No nucleotide polymorphism resulting in a codon change at codon 733 or other positions associated with knockdown resistance in other arthropods has been identified. These data may establish a reference line for future surveys of the susceptibility of S. scabiei in the area.
authors.affiliation: Department of Parasitology and Mycology, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Université Paris 13, Bobigny, France.
authors.forename: V
authors.initials: V
authors.lastname: Andriantsoanirina
authors.forename: A
authors.initials: A
authors.lastname: Izri
authors.forename: F
authors.initials: F
authors.lastname: Botterel
authors.forename: F
authors.initials: F
authors.lastname: Foulet
authors.forename: O
authors.initials: O
authors.lastname: Chosidow
authors.forename: R
authors.initials: R
authors.lastname: Durand
mesh_terms: D000818:Animals; D004351:Drug Resistance; D005602:France; D005838:Genotype; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D020125:Mutation, Missense; D010297:Paris; D011722:Pyrethrins / Q000494:pharmacology*; D012520:Sarcoptes scabiei / Q000187:drug effects*; D012532:Scabies / Q000469:parasitology*; D061566:Voltage-Gated Sodium Channels / Q000235:genetics*
chemical_list: D007306:Insecticides; D011722:Pyrethrins; D061566:Voltage-Gated Sodium Channels
keywords: Knockdown resistance; Sarcoptes scabiei; permethrin; pyrethroids; voltage-sensitive sodium channel