title: [Mechanism of psoriasis generation in animal models].
abstract: Psoriasis is a chronic inflammatory disease related to genome-wide and surroundings, it is important to develop a suitable animal model to research psoriasis pathogenesis and evolve pharmacotherapeutics. With the development of transgenetic technology in the past few years, psoriasis virulence gene animal model become a hotspot. Research of animal model of human psoriasis genes is reviewed in the paper.
authors.affiliation: Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Hu
mesh_terms: D000634:Aminoquinolines / Q000633:toxicity; D066258:Amphiregulin; D000818:Animals; D004195:Disease Models, Animal; D066255:EGF Family of Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D000077271:Imiquimod; D053547:Keratin-14 / Q000235:genetics / Q000378:metabolism; D053555:Keratin-5 / Q000235:genetics / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000819:agonists; D008822:Mice, Transgenic; D011565:Psoriasis / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D042787:Receptor, TIE-2 / Q000235:genetics / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D051199:Toll-Like Receptor 7 / Q000819:agonists; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism
chemical_list: D000634:Aminoquinolines; D066258:Amphiregulin; C587849:Areg protein, mouse; D066255:EGF Family of Proteins; D053547:Keratin-14; D053555:Keratin-5; D008562:Membrane Glycoproteins; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; C477038:Tlr7 protein, mouse; D051199:Toll-Like Receptor 7; D053773:Transforming Growth Factor beta1; D042787:Receptor, TIE-2; D000077271:Imiquimod