title: MNS16A tandem repeats minisatellite of human telomerase gene and cancer risk: a meta-analysis.
abstract: BACKGROUND
  Researchers have provided evidence that telomere dysfunction play an important role in cancer development. MNS16A is a polymorphic tandem repeats minisatellite of human telomerase (hTERT) gene that influences promoter activity of hTERT and thus implicates to relate with risk of several malignancies. However, results on association between MNS16A and cancer risk remain controversial. We therefore conduct a meta-analysis to derive a more precise estimation of association between MNS16A and cancer risk.
  
  
  METHODS
  A systematic literature search was conducted by searching PubMed, ISI Web of Knowledge, Human Genome and Epidemiology Network Navigator and Google Scholar digital database for publications on associations between MNS16A and cancer risk. Variants with statistically significant associations by meta-analysis were assessed using Venice criteria.
  
  
  RESULTS
  10 case-control articles enrolling 6101 cases and 10521 controls were brought into our meta-analysis. The relationships were strong epidemiological credibility in cerebral cancer and breast cancer population (P for heterogeneity > 0.1). The cumulative analysis in chronologic order suggested a clear tendency towards a significant association with additional study samples.
  
  
  CONCLUSIONS
  The results provided a more accurate depiction of the role of MNS16A in cerebral cancer and breast cancer susceptibility. Additional larger studies were warranted to validate our findings.
authors.affiliation: Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xia
authors.forename: Rui
authors.initials: R
authors.lastname: Rui
authors.forename: Sheng
authors.initials: S
authors.lastname: Quan
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.forename: Li
authors.initials: L
authors.lastname: Zou
authors.forename: Jiao
authors.initials: J
authors.lastname: Lou
authors.forename: Xuzai
authors.initials: X
authors.lastname: Lu
authors.forename: Juntao
authors.initials: J
authors.lastname: Ke
authors.forename: Ti
authors.initials: T
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D020080:Tandem Repeat Sequences; D019098:Telomerase / Q000235:genetics*
chemical_list: D019098:Telomerase