title: Cytokine and chemokine levels in patients infected with the novel avian influenza A (H7N9) virus in China.
abstract: H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Th17 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.
authors.affiliation: Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chi
authors.forename: Yefei
authors.initials: Y
authors.lastname: Zhu
authors.forename: Tian
authors.initials: T
authors.lastname: Wen
authors.forename: Lunbiao
authors.initials: L
authors.lastname: Cui
authors.forename: Yiyue
authors.initials: Y
authors.lastname: Ge
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Jiao
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Aihua
authors.initials: A
authors.lastname: Ge
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Changjun
authors.initials: C
authors.lastname: Bao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xian
authors.initials: X
authors.lastname: Qi
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Zhiyang
authors.initials: Z
authors.lastname: Shi
authors.forename: Fenyang
authors.initials: F
authors.lastname: Tang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xing
authors.forename: Minghao
authors.initials: M
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D016207:Cytokines
keywords: H7N9 avian influenza; chemokine; cytokine