title: Comparison of Serum Lipid Profiles between Normal Controls and Breast Cancer Patients.
abstract: BACKGROUND
  Researchers have reported association of plasma/serum lipids and lipoproteins with different cancers. Increase levels of circulating lipids and lipoproteins have been associated with breast cancer risk.
  
  
  OBJECTIVE
  THE AIM OF THIS STUDY IS TO COMPARE SERUM LIPID PROFILES: total-cholesterol (T-CHOL), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) between breast cancer patients and normal participants.
  
  
  METHODS
  A total of 403 women in this study were divided into two groups in the period during May 2006-April 2007. Blood samples were collected from 249 patients with early stage breast cancer and 154 normal controls for serum lipid profiles (T-CHOL, TG, HDL-C, LDL-C and VLDL-C) analysis using Hitachi 717 Autoanalyzer (Roche Diagnostic GmbH, Germany). TG, LDL-C and VLDL-C levels in breast cancer group were significantly increased as compared with normal controls group (P < 0.001), whereas HDL-C and T-CHOL levels were not.
  
  
  RESULTS
  The results of this study suggest that increased serum lipid profiles may associate with breast cancer risk in Thai women. Further studies to group important factors including, cancer stages, types of cancer, parity, and menopausal status that may affect to lipid profiles in breast cancer patients along with an investigation of new lipid profiles to clarify most lipid factors that may involve in breast cancer development are needed.
authors.affiliation: Division of Pathology, National Cancer Institute, Bangkok, Thailand.
authors.forename: Pikul
authors.initials: P
authors.lastname: Laisupasin
authors.forename: Warayupa
authors.initials: W
authors.lastname: Thompat
authors.forename: Saowakon
authors.initials: S
authors.lastname: Sukarayodhin
authors.forename: Adisak
authors.initials: A
authors.lastname: Sornprom
authors.forename: Yuttana
authors.initials: Y
authors.lastname: Sudjaroen
keywords: Breast cancer; lipid profiles; lipoprotein; serum lipids