title: Calpain-10 genetic polymorphisms and polycystic ovary syndrome risk: a meta-analysis and meta-regression.
abstract: Recent evidences suggest that common functional polymorphisms in the promoter region of the Calpain-10 gene may have an impact on an individual's susceptibility to polycystic ovary syndrome (PCOS), but individually published results are inconclusive. Our meta-analysis is aimed to provide a more precise estimation of the relationships between Calpain-10 genetic polymorphisms and PCOS risk. An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from inception through April 1st, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratio (OR) with 95% confidence interval (CI) was calculated. Fourteen case-control studies were included with a total of 2123 PCOS patients and 3612 healthy controls. Nine common SNPs in the Calpain-10 gene were addressed. Our meta-analysis indicated that UCSNP-19, UCSNP-63 and UCSNP-45 polymorphisms in the Calpain-10 gene might be associated with increased PCOS risk. However, no statistically significant association was observed in UCSNP-43, UCSNP-22, UCSNP-43, UCSNP-45, UCSNP-56, UCSNP-58, and UCSNP-110 polymorphisms. Further subgroup analysis by ethnicity revealed that UCSNP-19, UCSNP-63 and UCSNP-45 polymorphisms might decrease the risk of PCOS among Asian populations, but not among Caucasian populations. The current meta-analysis indicates that UCSNP-19, UCSNP-63 and UCSNP-45 polymorphisms in the Calpain-10 gene may be risk factors for PCOS, especially among Asian populations.
authors.affiliation: Department of Gynecology, The First Hospital of China Medical University, Shenyang 110001, PR China. Electronic address: cmu1h_swj@126.com.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Shen
authors.forename: Tianren
authors.initials: T
authors.lastname: Li
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Hu
authors.forename: Hongbo
authors.initials: H
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Song
mesh_terms: D000465:Algorithms; D044466:Asian People / Q000235:genetics; D002154:Calpain / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics; D017594:Publication Bias; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D002154:Calpain; C415197:calpain 10
keywords: CI; Calpain-10; HWE; Hardy–Weinberg equilibrium; Meta-analysis; Meta-regression; OR; PCOS; Polycystic ovary syndrome; Polymorphism; SNPs; confidence interval; odds ratio; polycystic ovary syndrome; single nucleotide polymorphisms