title: Weight reduction and maintenance with IQP-PV-101: a 12-week randomized controlled study with a 24-week open label period.
abstract: OBJECTIVE
  The safety and efficacy of IQP-PV-101, a proprietary extract of Phaseolus vulgaris, on weight management in two phases was evaluated here. The weight loss (WL) phase was conducted over 12 weeks and the weight maintenance (WM) phase took 24 weeks.
  
  
  METHODS
  In the double-blind WL phase, subjects were randomized to receive either IQP-PV-101 or placebo. All subjects adhered to a mildly hypocaloric diet. Body weight and other body composition parameters were measured at baseline and every 4 weeks thereafter. During the single arm, open label WM trial, energy intake was ad libitum. Efficacy parameters were measured at baseline, week 12 and week 24.
  
  
  RESULTS
  At the end of the WL study, the IQP-PV-101 group lost a mean of 2.91 ± 2.63 kg in body weight compared with 0.92 ± 2.00 kg in the placebo group (P < 0.001). During the WM phase, 36 out of 49 subjects (73.5%) were able to maintain their weight, even without dietary restrictions. No serious or related adverse events were reported over the combined period of 36 weeks.
  
  
  CONCLUSIONS
  Results indicate that IQP-PV-101 is safe and effective for weight loss and maintenance.
authors.affiliation: Practice for General Medicine, Berlin, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Grube
authors.forename: Wen-Fen
authors.initials: WF
authors.lastname: Chong
authors.forename: Pee-Win
authors.initials: PW
authors.lastname: Chong
authors.forename: Linda
authors.initials: L
authors.lastname: Riede
mesh_terms: D000293:Adolescent; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D004038:Diet, Reducing; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008297:Male; D062407:Meals; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy; D027805:Phaseolus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D055105:Waist Circumference; D015431:Weight Loss / Q000187:drug effects*; D055815:Young Adult
chemical_list: D010936:Plant Extracts