title: [Morphological and functional changes of organs of female and male reproductive systems at change of sex].
abstract: The aim of the study was to identify the effects of virilizing and feminizing hormone replacement therapy on the morphology and function of the male and female reproductive systems in the application of technology for change of sex. The results of the pathomorphorogic examination of the uterus with appendages, testes, the corpora cavernosa, and biopsies of the prostate and mammary glands at different times of treatment in transsexual patients aged from 22 to 43 years are presented. It was found that prolonged exposure to high concentrations of exogenous hormones in the women and men significantly increases the risk of tumors and tumor-like processes, such as endocervicosis, cervical intraepithelial neoplasia, metaplasia of the endometrium, endocervical and endometrial polyps, endometrial hyperplasia, proliferative processes in tubular epithelium, ovarian polycystic disease, mammary tumors, hyperplasia and metaplasia of the ductal epithelium of the prostate gland.
authors.forename: V V
authors.initials: VV
authors.lastname: Mikhaĭlichenko
authors.forename: V N
authors.initials: VN
authors.lastname: Fesenko
authors.forename: N V
authors.initials: NV
authors.lastname: Khmelnitskiĭ
authors.forename: I N
authors.initials: IN
authors.lastname: Ozhiganova
authors.forename: A I
authors.initials: AI
authors.lastname: Novikov
authors.forename: V V
authors.initials: VV
authors.lastname: Korolev
authors.forename: V S
authors.initials: VS
authors.lastname: Vasil'ev
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology* / Q000503:physiopathology; D004717:Endometrium / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology* / Q000503:physiopathology; D057829:Gender-Affirming Procedures; D013737:Testis / Q000473:pathology* / Q000503:physiopathology; D063106:Transgender Persons