title: Components of the CtBP1/BARS-dependent fission machinery.
abstract: The brefeldin A ADP-ribosylated substrate, a member of the C-terminal-binding protein family that is referred to as CtBP1/BARS, is a dual-function protein that acts as a transcriptional co-repressor in the nucleus and as an inducer of membrane fission in the cytoplasm. In this review, we first discuss the mechanisms that enable CtBP1/BARS to shift between the nuclear transcriptional co-repressor and the cytosolic fission-inducing activities. Then, we focus on the role of CtBP1/BARS in membrane fission. CtBP1/BARS controls several fission events including macropinocytosis, fluid-phase endocytosis, COPI-coated vesicle formation, basolaterally directed post-Golgi carrier formation, and Golgi partitioning in mitosis. We report on recent advances in our understanding of the CtBP1/BARS membrane fission machineries that operate at the trans-side and at the cis-side of the Golgi complex. Specifically, we discuss how these machineries are assembled and regulated, and how they operate in the formation of the basolaterally directed post-Golgi carriers.
authors.affiliation: Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131, Naples, Italy, c.valente@ibp.cnr.it.
authors.forename: Carmen
authors.initials: C
authors.lastname: Valente
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Daniela
authors.initials: D
authors.lastname: Corda
mesh_terms: D000818:Animals; D022181:COP-Coated Vesicles / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021601:trans-Golgi Network / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins