title: Molecular alterations and clinical relevance in esophageal squamous cell carcinoma.
abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100021, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shang
authors.forename: Mingrong
authors.initials: M
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D055088:Early Detection of Cancer; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D035683:MicroRNAs