title: Duodenal application of Li+ in a submaximal therapeutic dose inhibits exocrine pancreatic secretion and modulates gastro-duodenal myoelectrical activity in a conscious pig model.
abstract: This study tested whether duodenal application of lithium inhibits gastroduodenal motility, and whether it suppresses secretion from the exocrine pancreas. Five suckling pigs, 16-18 days old, were surgically fitted with 3 serosal electrodes on the wall of the gastric antrum and the duodenum for electromyography of smooth muscles, and with a pancreatic duct catheter and a duodenal T-cannula for collection and re-entrant flow of pancreatic juice. After the recovery period, on alternative days, each animal was tested once with an intraduodenal infusion of Li+ (100 mmol·L(-1) C3H5LiO3, 10 mL·kg(-1)·h(-1)) for 1 h, and once with an intraduodenal infusion of NaCl (154 mM, 10 ml·kg(-1)·h(-1)), also for 1 h, with the first treatment, i.e., Li+ or NaCl, randomly assigned. Individual pigs served as their own controls, with data recorded prior to a treatment being used as the baseline. Li+ increased the duration of quiescence (P < 0.05) and activity phase (P < 0.05) in the antrum, thus increasing (P < 0.05) the duration of antral myoelectrical cycles. Li+ shortened (P < 0.05) phase I, but it did not affect phase II or phase III or the MMC in the duodenum. Li+ inhibited pancreatic juice outflow as well as pancreatic enzyme and bicarbonate output (P < 0.05 for all pancreatic parameters).
authors.affiliation: Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, UK. v.naughton@ulster.ac.uk
authors.forename: Violetta
authors.initials: V
authors.lastname: Naughton
authors.forename: Mette S
authors.initials: MS
authors.lastname: Hedemann
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Naughton
authors.forename: Emeir
authors.initials: E
authors.lastname: McSorley
authors.forename: Helle N
authors.initials: HN
authors.lastname: Laerke
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001639:Bicarbonates / Q000378:metabolism; D002404:Catheterization; D003243:Consciousness; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology; D004576:Electromyography; D018020:Lithium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D023421:Models, Animal; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D046790:Pancreas, Exocrine / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D011706:Pyloric Antrum / Q000187:drug effects* / Q000502:physiology; D013552:Swine; D013997:Time Factors
chemical_list: D001639:Bicarbonates; D018020:Lithium Compounds