title: Iridium-catalyzed cycloaddition of azides and 1-bromoalkynes at room temperature.
abstract: Iridium dimer complexes were found to catalyze the [3 + 2] cycloaddition reaction of azides with bromoalkynes, yielding 1,5-disubstituted 4-bromo-1,2,3-triazoles in reasonable to excellent yields under mild conditions. The reaction offers a direct route to new 1,4,5-trisubstituted triazoles.
authors.affiliation: CEA , iBiTecS, Service de Chimie Bioorganique et de Marquage, F-91191 Gif sur Yvette, France.
authors.forename: Evelia
authors.initials: E
authors.lastname: Rasolofonjatovo
authors.forename: Sewan
authors.initials: S
authors.lastname: Theeramunkong
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bouriaud
authors.forename: Sergii
authors.initials: S
authors.lastname: Kolodych
authors.forename: Manon
authors.initials: M
authors.lastname: Chaumontet
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D006842:Hydrocarbons, Brominated; D014230:Triazoles; D007495:Iridium