title: A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination.
abstract: The functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary elimination.
authors.affiliation: IPCMS, UMR CNRS-UdS-ECPM 7504 23 rue du loess BP 43, 67034 Strasbourg, France. Sylvie.Begin@ipcms.u-strasbg.fr Delphine.Felder@ipcms.u-strasbg.fr.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ghobril
authors.forename: Gabriela
authors.initials: G
authors.lastname: Popa
authors.forename: Audrey
authors.initials: A
authors.lastname: Parat
authors.forename: Claire
authors.initials: C
authors.lastname: Billotey
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Taleb
authors.forename: Pauline
authors.initials: P
authors.lastname: Bonazza
authors.forename: Sylvie
authors.initials: S
authors.lastname: Begin-Colin
authors.forename: Delphine
authors.initials: D
authors.lastname: Felder-Flesch
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism; D004164:Diphosphonates / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D013154:Spleen / Q000378:metabolism
chemical_list: D050091:Dendrimers; D004164:Diphosphonates; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C104700:PAMAM Starburst; C000499:ferric oxide; D011092:Polyethylene Glycols