title: Nanomedicine as an innovative therapeutic strategy for pediatric lung diseases.
abstract: Nanomedicine is a rapidly emerging technology and represents an innovative field for therapy. Nanomaterials have intrinsically defined features for biomedical applications due to the high specific surface area, the amazing diversity, versatility in structure and function and the possibility of surface charge. In particular, the functionalization of targeting or stimuli-responsive unit on the surface of these materials gives them specific targeted therapeutic properties. There are many pediatric lung diseases that could potentially benefit from nanomedicine. Herein, we aim to review various drug carrier systems and release systems specifically targeting pediatric lung diseases. The injection of nanomedicine into in vivo models and their elimination will also be discussed. Finally, the potential toxicity of nanomaterials will be addressed.
authors.affiliation: Department of Mechanical and Manufacturing Engineering, University of Manitoba, Winnipeg, Manitoba; Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Zahtabi
authors.forename: Richard
authors.initials: R
authors.lastname: Keijzer
authors.forename: Malcolm
authors.initials: M
authors.lastname: Xing
mesh_terms: D002648:Child; D004337:Drug Carriers; D006801:Humans; D008171:Lung Diseases / Q000628:therapy*; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers
keywords: drug delivery; gene delivery; lung; nanomedicine; nanotoxicity; targeted release