title: Concentrated sodium chloride catheter lock solution--a new effective alternative method for hemodialysis patients with high bleeding risk.
abstract: BACKGROUND
  Locking catheter with heparin may increase bleeding risk of some hemodialysis (HD) patients. Hence, the security and effectivity of 10% concentrated sodium chloride (CSC) used as an alternative method for patients with high bleeding risk need to be investigated.
  
  
  METHODS
  Seventy-two patients inserted temporary central venous catheters were divided into two groups randomly. A total of 3125 U/mL heparin saline (HS) was used in HS group and 10% CSC in CSC group to lock catheters. Heparin-free HD was used for the first time and plasma specimens were collected to test coagulation indicators before catheter-locking (at the end of HD) and at 30 min after it. Then, blood flow velocities (BFVs), incidences of catheter thrombosis, etc. were followed up at each time of HD.
  
  
  RESULTS
  Activated partial thromboplastin time (APTT) of two groups had no difference at the end of heparin-free HD (27.100 [25.675-28.950] vs. 27.250 [25.150-29.575] second, p = 0.933), but at 30 minutes after using different catheter lock solutions, APTT of HS group was obviously longer than CSC group (50.100 [41.275-65.400] vs. 27.500 [25.525-29.875] second, p < 0.001). Catheters' retaining time of two groups were the same (p = 0.306), so did the average BFVs (p > 0.05). But catheters' thrombosis incidence and urokinase usage of HS group were less than CSC group (p < 0.05).
  
  
  CONCLUSIONS
  Comparing with HS group, thrombosis incidences of CSC group increased, but catheters' retaining time and average BFVs remained the same and coagulation indicators of it were unaffected. Therefore, it can be an effective alternative lock method for HD patients with high bleeding risk.
authors.affiliation: Department of Nephrology, the First Affiliated Hospital of People's Liberation Army (PLA) General Hospital , Beijing , China.
authors.forename: Feng-Kun
authors.initials: FK
authors.lastname: Chen
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Yi-Yan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Pu
authors.initials: P
authors.lastname: Chen
authors.forename: Chang-Zheng
authors.initials: CZ
authors.lastname: Zhao
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Gong
authors.forename: Dong-Fang
authors.initials: DF
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D062905:Central Venous Catheters; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D012306:Risk; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride