title: Corrosion resistance and in vitro response of a novel Ti35Nb2Ta3Zr alloy with a low Young's modulus.
abstract: β type titanium alloys have attracted much attention in the biomedical field because they consist of non-cytotoxic elements, show high corrosion resistance, and are biologically compatible. In this study, a novel β type titanium alloy (Ti35Nb3Zr2Ta) with a Young's modulus of 48 GPa was fabricated and the alloy's corrosion resistance and in vitro response were determined. The results indicate that the novel alloy exhibits comparable corrosion resistance when compared with Ti6Al4V, but in vitro experiments show that osteoblasts attach, spread, proliferate, and differentiate better on Ti35Nb2Ta3Zr than on Ti6Al4V. The high corrosion resistance and satisfactory biocompatibility make the novel Ti35Nb3Zr2Ta alloy a promising biomaterial for surgical implants.
authors.affiliation: Department of Orthopaedics, Qilu Hospital, Shandong University, Jinan 250012, People's Republic of China. Orthopaedic Department, The Sixth Affiliated People's Hospital, Medical School of ShangHai JiaoTong University, Shanghai, People's Republic of China.
authors.forename: Yongyuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Desheng
authors.initials: D
authors.lastname: Chen
authors.forename: Weijie
authors.initials: W
authors.lastname: Lu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Jia
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wang
authors.forename: Xianlong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D016475:3T3 Cells; D000469:Alkaline Phosphatase / Q000378:metabolism; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002448:Cell Adhesion; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D055119:Elastic Modulus; D017097:Electric Impedance; D051379:Mice; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D009556:Niobium; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D016133:Polymerase Chain Reaction / Q000379:methods; D011199:Potentiometry; D013499:Surface Properties; D013635:Tantalum; D014025:Titanium; D015040:Zirconium
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009556:Niobium; D013635:Tantalum; D015040:Zirconium; D014025:Titanium; D000469:Alkaline Phosphatase; D002118:Calcium