title: Meta-analysis of patients taking statins before revascularization and aortic valve surgery.
abstract: Statin intake before cardiac surgery is associated with favorable outcomes. We sought to analyze the evidence for statin pretreatment before isolated coronary artery bypass graft surgery and aortic valve replacement surgery. In this meta-analysis, we demonstrate beneficial results for the endpoints mortality, stroke, atrial fibrillation, and length of stay in hospital in 36,053 statin-pretreated coronary artery bypass graft surgery patients compared with control subjects retrieved from 32 studies, but fail to detect relevant advantages through preoperative statin therapy for 3,091 patients undergoing aortic valve replacement from four trials. Strict adherence to guidelines recommending statin treatment before CABG surgery is therefore mandatory.
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany. Electronic address: elmar.kuhn@uk-koeln.de.
authors.forename: Elmar W
authors.initials: EW
authors.lastname: Kuhn
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Liakopoulos
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Stange
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Antje-Christin
authors.initials: AC
authors.lastname: Deppe
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Ingo
authors.initials: I
authors.lastname: Slottosch
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Scherner
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Yeong-Hoon
authors.initials: YH
authors.lastname: Choi
authors.affiliation: Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Wahlers
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D001026:Coronary Artery Bypass; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: 16, 23; AF; AVR; CABG; CI; LDL; MI; OR; RCT; aortic valve replacement; atrial fibrillation; confidence interval; coronary artery bypass graft; low-density lipoprotein; myocardial infarction; odds ratio; randomized controlled trial