title: Xeroderma pigmentosum complementation group f polymorphisms influence risk of glioma.
abstract: We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.
authors.affiliation: Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Cheng
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.forename: Ru-You
authors.initials: RY
authors.lastname: Zhang
authors.forename: Shao-Shan
authors.initials: SS
authors.lastname: Hu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Wu
authors.initials: W
authors.lastname: Yue
mesh_terms: D044466:Asian People; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D014983:Xeroderma Pigmentosum / Q000235:genetics*