title: In scarcity and abundance: metabolic signals regulating cell growth.
abstract: Although nutrient availability is a major driver of cell growth, and continuous adaptation to nutrient supply is critical for the development and survival of all organisms, the molecular mechanisms of nutrient sensing are only beginning to emerge. Here, we highlight recent advances in the field of nutrient sensing and discuss arising principles governing how metabolism might regulate growth-promoting pathways. In addition, we discuss signaling functions of metabolic enzymes not directly related to their metabolic activity.
authors.affiliation: Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
authors.forename: Shady
authors.initials: S
authors.lastname: Saad
authors.forename: Matthias
authors.initials: M
authors.lastname: Peter
authors.forename: Reinhard
authors.initials: R
authors.lastname: Dechant
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D049108:Cell Enlargement; D049109:Cell Proliferation; D002470:Cell Survival; D004734:Energy Metabolism; D019143:Evolution, Molecular; D006801:Humans; D015398:Signal Transduction