title: Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs.
abstract: Stereotactic radiosurgery (SRS) is a procedure that delivers a single large radiation dose to a well-defined target. Here, we describe a frameless SRS technique suitable for intracranial targets in canines. Medical records of dogs diagnosed with a primary intracranial tumour by imaging or histopathology that underwent SRS were retrospectively reviewed. Frameless SRS was used successfully to treat tumours in 51 dogs with a variety of head sizes and shapes. Tumours diagnosed included 38 meningiomas, 4 pituitary tumours, 4 trigeminal nerve tumours, 3 gliomas, 1 histiocytic sarcoma and 1 choroid plexus tumour. Median survival time was 399 days for all tumours and for dogs with meningiomas; cause-specific survival was 493 days for both cohorts. Acute grade III central nervous system toxicity (altered mentation) occurred in two dogs. Frameless SRS resulted in survival times comparable to conventional radiation therapy, but with fewer acute adverse effects and only a single anaesthetic episode required for therapy.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Mariani
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Schubert
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: House
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Wong
authors.affiliation: North Florida Neurology, Orange Park, FL, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Hopkins
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Barnes Heller
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Milner
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: N V
authors.initials: NV
authors.lastname: Lester
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Lurie
authors.affiliation: Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Rajon
authors.affiliation: Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Friedman
authors.affiliation: Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Bova
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D003390:Cranial Nerve Neoplasms / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D004283:Dog Diseases / Q000401:mortality / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D008579:Meningioma / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D010911:Pituitary Neoplasms / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D016634:Radiosurgery / Q000379:methods / Q000662:veterinary*; D012189:Retrospective Studies; D016019:Survival Analysis; D020433:Trigeminal Nerve Diseases / Q000401:mortality / Q000601:surgery / Q000662:veterinary
keywords: brain tumour; canine; meningioma; radiation oncology; small animal