title: Within-laboratory and between-laboratory variability in the measurement of anti-müllerian hormone determined within an external quality assurance scheme.
abstract: Ten laboratories in an external quality assurance scheme used the same assay to measure anti-müllerian hormone concentration (Beckman Coulter Gen II) and received twenty serum samples distributed over a 15 month period. The mean bias for all results was only -0.089%, but there was large coefficient of repeatability of 38.8% (sample bias ranged from -37.9% to +54.7%). While each laboratory showed good reproducibility, there was a wide range of average values relative to the consensus value from -24.0% to +22.7%. This between-laboratory variability suggests clinicians should use the same laboratory to avoid problems with result interpretation.
authors.affiliation: External Quality Assurance Schemes for Reproductive Medicine, PO Box 162, Northlands, WA 6905, Australia; Fertility Specialists of Western Australia, Bethesda Hospital, 25 Queenslea Drive, Claremont, WA 6010, Australia. Electronic address: info@eqasrm.com.au.
authors.forename: Emily
authors.initials: E
authors.lastname: Zuvela
authors.forename: Melanie
authors.initials: M
authors.lastname: Walls
authors.forename: Phillip
authors.initials: P
authors.lastname: Matson
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001315:Australia; D004355:Drug Stability; D005260:Female; D006801:Humans; D007753:Laboratories / Q000592:standards*; D008875:Middle Aged; D009520:New Zealand; D011786:Quality Control; D015203:Reproducibility of Results; D013048:Specimen Handling
chemical_list: D054304:Anti-Mullerian Hormone
keywords: AMH; External quality assurance