title: [Expression of bone histomorphometry parameters in rabbit condyle during mandibular forward positioning].
abstract: OBJECTIVE
  To observe the changes of bone histomorphometry parameters in condyle of rabbits during mandibular forward positioning.
  
  
  METHODS
  Forty rabbits with eight weeks of age were simple randomly divided into the experimental group (n = 24) and control group (n = 16).Mandibles of rabbits in the experimental groups were induced to forward position by a functional appliance.The experimental group and control group were sacrificed after 2 and 4, 8, 12 weeks.The specimens from right tempromandibular joints were processed for undemineralised sections.These sections were used for fluorescent microscopy observation and the measurement of bone histomorphometry.
  
  
  RESULTS
  At 8 week bone-volume fraction [(75.83 ± 1.10)%], trabecular thickness [(103.28 ± 2.89) µm], trabecular number [(2.86 ± 0.06) mm(-1)], mineral apposition rate [(2.32 ± 0.02) µm/d] and index of osteoblast [(30.20 ± 0.47) N/mm(2)] in subchondral region of the cartilage in the experimental group were significantly increased compared with the age-matched controls [respectively (64.00 ± 1.54)%, (87.00 ± 1.13) µm, (1.84 ± 0.08) mm(-1), (1.69 ± 0.02) µm/d and (21.07 ± 0.59) N/mm(2)] (P < 0.05). However, trabecular separation [(170.00 ± 2.25) µm] was lower than those in the controls [(241.50 ± 1.57) µm] with significant difference(P < 0.05). There was no significant difference in the bone histomorphometry parameters of the central region between the experimental group and the age-matched control group (P > 0.05).
  
  
  CONCLUSIONS
  The pattern of bone histomorphometry parameters expression in subchondral region has a high correlation with the adaptive remodeling of the condyle after functional appliance.
authors.affiliation: Department of Stomatology, Zhejiang University, Hangzhou, China. zjuzj1977@163.com
authors.forename: Jing
authors.initials: J
authors.lastname: Zhan
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D000818:Animals; D002356:Cartilage / Q000033:anatomy & histology / Q000254:growth & development; D005260:Female; D008297:Male; D019186:Mandibular Advancement; D008335:Mandibular Condyle / Q000033:anatomy & histology / Q000254:growth & development; D017289:Orthodontic Appliances, Functional; D011817:Rabbits; D011897:Random Allocation