title: Efficacy and duration of immunity after yellow fever vaccination: systematic review on the need for a booster every 10 years.
abstract: Abstract. Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus-infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus-infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.
authors.affiliation: Instituto de Medicina Tropical Alexander von Humbolt, Lima, Peru. eduardo.gotuzzo@upch.pe
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: Sergio
authors.initials: S
authors.lastname: Yactayo
authors.forename: Erika
authors.initials: E
authors.lastname: Córdova
mesh_terms: D000917:Antibody Formation; D006801:Humans; D007109:Immunity / Q000276:immunology; D007117:Immunization, Secondary; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014611:Vaccination / Q000379:methods*; D015004:Yellow Fever / Q000276:immunology / Q000517:prevention & control*; D022341:Yellow Fever Vaccine / Q000008:administration & dosage* / Q000276:immunology; D015005:Yellow fever virus
chemical_list: D022341:Yellow Fever Vaccine