title: BoneNET: a network model of bone microstructure and dynamics.
abstract: We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density (BMD) and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.
authors.affiliation: Department of Computer Science and Engineering, State University of New York at Buffalo, 201 Bell Hall, Buffalo 14260-2000, New York, USA. thkim7@buffalo.edu
authors.forename: Taehyong
authors.initials: T
authors.lastname: Kim
authors.forename: Lawrence
authors.initials: L
authors.lastname: Bone
authors.forename: Murali
authors.initials: M
authors.lastname: Ramanathan
authors.forename: Aidong
authors.initials: A
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling; D001842:Bone and Bones / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D008954:Models, Biological; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D012984:Software