title: Clinical significance of MYT1L gene polymorphisms in Chinese patients with gastric cancer.
abstract: BACKGROUND
  Myelin transcription factor 1 (MYT1) and its homologue MYT1-like (MYT1L) are the two main members of MYT/NZF family transcription factors, which are highly related, share a high degree of identity and show similar regulatory functions in neural development. There are evidences from several cytology experiments showing that MYT1 is associated with carcinoma.
  
  
  RESULTS
  In the present study, we genotyped 944 surgically resected gastric cancer patients by the SNaPshot method to explore the association of MYT1L rs17039396 polymorphism with survival of gastric cancer in a Chinese population. We found that cardia cancer patients carrying MYT1L rs17039396 GG genotype survived for a significantly shorter time than those carrying the GA genotype. This significance was enhanced in the dominant model (GG vs. GA/AA, log-rank P = 0.001), suggesting a potential protect role of the variant A allele. Multivariate Cox regression analyses showed that the AG/GG genotypes were associated with a significantly decreased risk of death from gastric cancer (adjusted hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.40-0.81). Stratification analyses further showed that such protective effect was statistically significant in subgroups of patients with tumor size ≤5 cm (adjusted HR = 0.34, 95%CI = 0.19-0.64), well-moderate gastric cancer (adjusted HR = 0.59, 95%CI = 0.35-0.98), no lymph-node metastasis (adjusted HR = 0.49, 95%CI = 0.31-0.76), no distant metastasis (adjusted HR = 0.59, 95%CI = 0.41-0.84).
  
  
  CONCLUSIONS
  In conclusion, these data represents the first demonstration that MYT1L rs17039396 variants could indentified as a favorable prognostic indicator for gastric cancer, particularly among the cardia gastric cancer. Further validation in other larger studies with different ethnic populations and functional evaluations are needed.
authors.affiliation: Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China ; Department of Oncology, Xuzhou Central Hospital, Affiliated Xuzhou Hospital, College of Medicine, Southeast University, Xuzhou, Nanjing.
authors.forename: Yangmei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haixia
authors.initials: H
authors.lastname: Zhu
authors.forename: Xunlei
authors.initials: X
authors.lastname: Zhang
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.forename: Xichang
authors.initials: X
authors.lastname: Zhou
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Cao
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wu
authors.forename: Weida
authors.initials: W
authors.lastname: Gong
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Tang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhou
authors.forename: Cuiju
authors.initials: C
authors.lastname: Tang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jinfei
authors.initials: J
authors.lastname: Chen
mesh_terms: D002299:Cardia / Q000473:pathology*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C561020:MYT1L protein, human; D009419:Nerve Tissue Proteins; D014157:Transcription Factors