title: Terlipressin-induced hyponatremic seizure in a child.
abstract: Terlipressin, an analog of the natural hormone arginine-vasopressin, is a splanchnic constrictor that is used to control variceal bleeding in portal hypertension. It has a very good safety profile compared to vasopressin. Although rare, adverse effects such as hyponatremia and seizure can occur. We describe a 7-year-old male child who developed hyponatremia induced by infusion of terlipressin which resulted in a generalized seizure. After withdrawal of terlipressin, the serum sodium level became normal. Through this case, we emphasize the importance of monitoring patient's electrolyte levels during the course of terlipressin therapy.
authors.affiliation: Department of Pediatrics, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai, India.
authors.forename: Syed Ahmed
authors.initials: SA
authors.lastname: Zaki
mesh_terms: D002648:Child; D006396:Hematemesis / Q000188:drug therapy; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D008236:Lypressin / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D012640:Seizures / Q000139:chemically induced*; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin
keywords: Adverse drug reaction; children; hyponatremia; terlipressin