title: Applications of poly(ethylene oxide) in controlled release tablet systems: a review.
abstract: To improve therapeutic effects and compatibility of patients, controlled release tablet systems based on polymers are of great interest for pharmaceutical technologies. Poly(ethylene oxide) (PEO) is a non-ionic linear hydrophilic and uncrosslinked polymer available in a number of molecular weights. It is synthesized by ethylene oxide and has many desirable properties for drug delivery applications. This review article aims to summary the recent developments on physicochemical properties of PEO and focus on the recent efforts and developments on PEO as oral controlled release matrix tablets, bioadhesive hydrophilic matrices and osmotic pump tablets. Commercial products employed PEO were also discussed.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Second Military Medical University , Shanghai , PR China and.
authors.forename: Lulu
authors.initials: L
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Deng
authors.forename: Jianming
authors.initials: J
authors.lastname: Chen
mesh_terms: D000268:Adhesiveness; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D013607:Tablets; D014783:Viscosity
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D011092:Polyethylene Glycols
keywords: Bioadhesive hydrophilic matrix; PEO; commercial product; controlled release tablet; matrix tablet; osmotic pump tablet; physicochemical properties