title: Stability of cefmetazole sodium in 5% dextrose injection and 0.9% sodium chloride injection.
abstract: The stability of cefmetazole sodium in 5% dextrose injection and 0.9% sodium choloride injection has been studied using a stability-indicating, high performance liquid chromatography (HPLC) assay method developed in our laboratory. This HPLC method is precise and accurate, with a percent relative standard deviation of 1.4 based on five readings. The admixtures were stable for two days at 25 deg C and for 28 days at 5 deg C, and they remained clear throughout the study period. The pH values decreased from 4.7 to 4.0 in 0.9% sodium chloride injection and from 4.8 to 4.2 in 5% dextrose injection. The expiry date of seven days at 5 deg C recommended by the manufacturer appears to be conservative from a chemical-stability standpoint.
authors.affiliation: Pharmaceutics Division, University of Houston, Houston, TX.
authors.forename: V D
authors.initials: VD
authors.lastname: Gupta
authors.forename: J
authors.initials: J
authors.lastname: Mawoswe
authors.forename: R E
authors.initials: RE
authors.lastname: Bailey