title: The influence of different therapeutic modalities and platelet rich plasma on apexogenesis: a preliminary study in monkeys.
abstract: BACKGROUND
  Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp.
  
  
  OBJECTIVE
  To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis.
  
  
  METHODS
  The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec®, Stomygen) and PRP (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia.). Histological and radiological evaluations were done six months after the treatment.
  
  
  RESULTS
  Considering the differences between HAP+PRP treated teeth in the pulpotomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance.
  
  
  CONCLUSIONS
  The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis.
authors.affiliation: Department of Preventive and Pediatric Dentistry, School of Dental Medicine, University of Belgrade, Serbia.
authors.forename: Vanja
authors.initials: V
authors.lastname: Petrović
authors.forename: Nataša
authors.initials: N
authors.lastname: Pejčić
authors.forename: Saša
authors.initials: S
authors.lastname: Cakić
mesh_terms: D000818:Animals; D056624:Apexification; D002522:Chlorocebus aethiops; D003782:Dental Pulp / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003789:Dental Pulp Exposure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D017886:Durapatite / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D053657:Platelet-Rich Plasma / Q000378:metabolism*; D011672:Pulpotomy; D011859:Radiography; D012038:Regeneration / Q000187:drug effects; D013997:Time Factors; D014070:Tooth / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D017886:Durapatite