title: Direct and mediated effects of cognitive function with multidimensional outcome measures in schizophrenia: the role of functional capacity.
abstract: Although cognitive ability is a known predictor of real-world functioning in schizophrenia, there has been an expanded interest in understanding the mechanisms by which it explains real-world functioning in this population. We examined the extent to which functional capacity (i.e., skills necessary to live independently) mediated the relationship between cognitive ability and both observer and self-reported real-world functioning in 138 outpatients with schizophrenia. Functional capacity significantly mediated the relations between cognitive ability and observer-rated real-world functioning, but not self-reported real-world functioning, with small to medium effect sizes observed for all outcomes. The role of cognitive ability in observer versus self-reported real-world functioning may be explained by different mechanisms.
authors.affiliation: a Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California , San Diego , CA , USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Ho
authors.forename: Raeanne C
authors.initials: RC
authors.lastname: Moore
authors.forename: Taylor
authors.initials: T
authors.lastname: Davine
authors.forename: Veronica
authors.initials: V
authors.lastname: Cardenas
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Bowie
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Patterson
authors.forename: Brent T
authors.initials: BT
authors.lastname: Mausbach
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000328:Adult; D003071:Cognition; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care; D012559:Schizophrenia / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D057566:Self Report