title: Fabrication and Evaluation of Curcumin-loaded Nanoparticles Based on Solid Lipid as a New Type of Colloidal Drug Delivery System.
abstract: Curcumin has very broad spectrum of biological activities; however, photodegradation, short half-life and low bioavailability have limited its clinical application. Curcumin-loaded solid lipid nanoparticles were studied to overcome these problems. The aim of this study was to optimize the best formulation on curcumin-loaded solid lipid nanoparticles. Emulsion-evaporation and low temperature-solidification technique was applied with monostearin as lipid carriers. The single factor analysis and orthogonal design were used to optimize formulation and various parameters were investigate. By the optimisation of a single factor analysis and orthogonal test, the particles size, polydispersity index, zeta potential, encapsulation efficiency and drug loading capacity of the optimised formulation were 99.99 nm, 0.158, -19.9 mV, 97.86%, and 4.35%, respectively. The differential scanning calorimetry and X-ray diffraction analysis results demonstrated new structure was formed in nanoparticles. The release kinetics in vitro demonstrated curcumin-loaded solid lipid nanoparticles can control drug release. These studies confirmed that curcumin-loaded solid lipid nanoparticles could be prepared successfully with high drug entrapment efficiency and loading capacity. Curcumin-loaded solid lipid nanoparticles may be a promising drug delivery system to control drug release and improve bioavailability.
authors.affiliation: Department of Pharmacy, The Second People's Hospital of Hefei, Hefei-230 011, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: W T
authors.initials: WT
authors.lastname: Dai
authors.forename: Z M
authors.initials: ZM
authors.lastname: He
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: J M
authors.initials: JM
authors.lastname: Gong
authors.forename: H Y
authors.initials: HY
authors.lastname: Xing
authors.forename: W D
authors.initials: WD
authors.lastname: Chen
keywords: Curcumin; preparation; release; solid lipid nanoparticles
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