title: Correlation between Th17 cells and tumor microenvironment.
abstract: Since their identification in 2005, T helper (TH)17 cells have been proposed to play important roles in several human diseases, including various autoimmune conditions, inflammations, allergy, and tumors. Focusing on human studies, we review the current understanding of molecular interactions (IL-1β, IL-6, IL-23, IL-21 and TGF-β), the signaling pathway (STAT3→RORγt) and the migration (induced by CCR6/CCL20) that contribute to Th17 differentiation and function in tumor microenvironment. Furthermore, we also make a synthesis of contradictory conclusions as to the roles that these cells are playing in the process of tumourigenesis in order to provide guidance of Th17-targeted therapy in tumors.
authors.affiliation: Department of Histology and Embryology, Tianjin Medical University, Tianjin, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Qi
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.forename: Junyan
authors.initials: J
authors.lastname: Wang
mesh_terms: D063646:Carcinogenesis / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology; D050796:STAT3 Transcription Factor / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D016207:Cytokines; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human
keywords: IL-17; Th17 cells; Tumor microenvironment