title: Performance and reproducibility of gynecologic cytology interpretation using the FocalPoint system: results of the RODEO Study Team.
abstract: OBJECTIVE
  To assess whether automated screening in the cytologic examination of Papanicolaou smear slides results in smaller margins of error than manual screening.
  
  
  METHODS
  We compared cytotechnologists' performance and reproducibility of manual and automated screening of 10,165 consecutive cervical cytology slides examined at Barretos Cancer Hospital using the FocalPoint system.
  
  
  RESULTS
  In total, 83% of atypical squamous cells of undetermined significance and greater were classified as quintiles 1 and 2; no high-grade squamous intraepithelial lesions and greater were observed in quintile 5. No statistically significant differences were found between manual and automated screening, using cervical biopsy specimens as the gold standard.
  
  
  CONCLUSIONS
  FocalPoint safely screened high-grade lesions, which can be valuable for high-workload routines.
authors.affiliation: Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of São Paulo, 1246-903 São Paulo, Brazil; e-mail: longatto16@hotmail.com.
authors.forename: Maíra Degiovani
authors.initials: MD
authors.lastname: Stein
authors.forename: José Humberto T G
authors.initials: JH
authors.lastname: Fregnani
authors.forename: Cristovam
authors.initials: C
authors.lastname: Scapulatempo
authors.forename: Allini
authors.initials: A
authors.lastname: Mafra
authors.forename: Natália
authors.initials: N
authors.lastname: Campacci
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057205:Automation, Laboratory / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D065006:Papanicolaou Test; D015203:Reproducibility of Results; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000175:diagnosis; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000175:diagnosis*; D014626:Vaginal Smears / Q000295:instrumentation* / Q000379:methods* / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Automation; FocalPoint; Pap test; Quality control; SurePath