title: A microRNA encoded by Autographa californica nucleopolyhedrovirus regulates expression of viral gene ODV-E25.
abstract: Baculovirus-encoded microRNAs (miRNAs) have been described in Bombyx mori nucleopolyhedrovirus; however, most of their functions remain unclear. Here we report the identification and characterization of an miRNA encoded by Autographa californica nucleopolyhedrovirus. The identified miRNA, AcMNPV-miR-1, perfectly matched a segment in the coding sequence of the viral gene ODV-E25 and downregulated ODV-E25 mRNA expression, which likely resulted in a reduction of infectious budded virions and accelerated the formation of occlusion-derived virions.
authors.affiliation: School of Life Science, Sun Yat-sen University, Guangzhou, People's Republic of China.
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Zhu
authors.forename: Jinwen
authors.initials: J
authors.lastname: Wang
authors.forename: Riqiang
authors.initials: R
authors.lastname: Deng
authors.forename: Peiwen
authors.initials: P
authors.lastname: Xiong
authors.forename: Hai
authors.initials: H
authors.lastname: Liang
authors.forename: Xunzhang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D015536:Down-Regulation; D015967:Gene Expression Regulation, Viral; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D017924:Nucleopolyhedroviruses / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018411:Spodoptera; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs; C585489:ODV-E25 protein, Autographa californica nucleopolyhedrovirus; D012367:RNA, Viral; D014759:Viral Envelope Proteins
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