title: Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial.
abstract: It is unclear whether regular exercise alone (no caloric restriction) is a useful strategy to reduce adiposity and obesity-related metabolic risk factors in obese girls. We examined the effects of aerobic (AE) vs. resistance exercise (RE) alone on visceral adipose tissue (VAT), intrahepatic lipid, and insulin sensitivity in obese girls. Forty-four obese adolescent girls (BMI ≥95th percentile, 12-18 yr) with abdominal obesity (waist circumference 106.5 ± 11.1 cm) were randomized to 3 mo of 180 min/wk AE (n = 16) or RE (n = 16) or a nonexercising control group (n = 12). Total fat and VAT were assessed by MRI and intrahepatic lipid by proton magnetic resonance spectroscopy. Intermuscular AT (IMAT) was measured by CT. Insulin sensitivity was evaluated by a 3-h hyperinsulinemic (80 mU·m(2)·min(-1)) euglycemic clamp. Compared with controls (0.13 ± 1.10 kg), body weight did not change (P > 0.1) in the AE (-1.31 ± 1.43 kg) and RE (-0.31 ± 1.38 kg) groups. Despite the absence of weight loss, total body fat (%) and IMAT decreased (P < 0.05) in both exercise groups compared with control. Compared with control, significant (P < 0.05) reductions in VAT (Δ-15.68 ± 7.64 cm(2)) and intrahepatic lipid (Δ-1.70 ± 0.74%) and improvement in insulin sensitivity (Δ0.92 ± 0.27 mg·kg(-1)·min(-1) per μU/ml) were observed in the AE group but not the RE group. Improvements in insulin sensitivity in the AE group were associated with the reductions in total AT mass (r = -0.65, P = 0.02). In obese adolescent girls, AE but not RE is effective in reducing liver fat and visceral adiposity and improving insulin sensitivity independent of weight loss or calorie restriction.
authors.affiliation: Division of Weight Management and Wellness and.
authors.forename: SoJung
authors.initials: S
authors.lastname: Lee
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Deldin
authors.forename: David
authors.initials: D
authors.lastname: White
authors.forename: YoonMyung
authors.initials: Y
authors.lastname: Kim
authors.forename: Ingrid
authors.initials: I
authors.lastname: Libman
authors.forename: Michelle
authors.initials: M
authors.lastname: Rivera-Vega
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuk
authors.forename: Sandra
authors.initials: S
authors.lastname: Sandoval
authors.forename: Chris
authors.initials: C
authors.lastname: Boesch
authors.forename: Silva
authors.initials: S
authors.lastname: Arslanian
mesh_terms: D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000367:Age Factors; D002648:Child; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000628:therapy; D055070:Resistance Training; D015431:Weight Loss / Q000502:physiology
keywords: adolescents; exercise; insulin sensitivity; intrahepatic lipid; visceral fat
references.citation: Diabetes Care. 1995 Feb;18(2):245-50
references.pmid: 7729306
references.citation: Metabolism. 2005 Nov;54(11):1472-9
references.pmid: 16253636
references.citation: Ann Intern Med. 2007 Sep 18;147(6):357-69
references.pmid: 17876019
references.citation: Diabetes Care. 2003 Nov;26(11):2977-82
references.pmid: 14578226
references.citation: J Appl Physiol (1985). 2005 Sep;99(3):1220-5
references.pmid: 15860689
references.citation: Arteriosclerosis. 1990 Jul-Aug;10(4):493-6
references.pmid: 2196039
references.citation: N Engl J Med. 2004 Jun 3;350(23):2362-74
references.pmid: 15175438
references.citation: Med Sci Sports Exerc. 1998 Dec;30(12):1738-43
references.pmid: 9861608
references.citation: Nutr Rev. 1981 Feb;39(2):43-55
references.pmid: 7010232
references.citation: Pediatrics. 2006 Oct;118(4):1388-93
references.pmid: 17015527
references.citation: J Clin Endocrinol Metab. 2010 May;95(5):2426-32
references.pmid: 20219892
references.citation: Circulation. 2009 Apr 21;119(15):2114-23
references.pmid: 19332459
references.citation: Pediatrics. 2002 Jan;109(1):45-60
references.pmid: 11773541
references.citation: Am J Clin Nutr. 2000 Apr;71(4):885-92
references.pmid: 10731493
references.citation: Lancet. 2003 Sep 20;362(9388):951-7
references.pmid: 14511928
references.citation: MAGMA. 2001 May;12(2-3):141-52
references.pmid: 11390270
references.citation: J Obes. 2011;2011:159373
references.pmid: 21772999
references.citation: Biochem Soc Trans. 2003 Dec;31(Pt 6):1281-5
references.pmid: 14641043
references.citation: J Pediatr. 2008 Feb;152(2):177-84
references.pmid: 18206686
references.citation: Diabetes Care. 2007 Aug;30(8):2091-7
references.pmid: 17475936
references.citation: Obesity (Silver Spring). 2010 Feb;18(2):384-90
references.pmid: 19696755
references.citation: Diabetes. 2002 Oct;51(10):3014-9
references.pmid: 12351441
references.citation: Diabetologia. 2012 May;55(5):1424-34
references.pmid: 22246378
references.citation: Diabetes. 2012 Nov;61(11):2787-95
references.pmid: 22751691
references.citation: Diabetes Care. 1999 Feb;22(2):345-54
references.pmid: 10333956
references.citation: N Engl J Med. 2002 Sep 5;347(10):709-15
references.pmid: 12213941
references.citation: Diabetes Care. 2006 Jul;29(7):1567-72
references.pmid: 16801580
references.citation: J Clin Endocrinol Metab. 2000 Jul;85(7):2463-8
references.pmid: 10902794
references.citation: N Engl J Med. 1996 Oct 31;335(18):1357-62
references.pmid: 8857019
references.citation: Hepatology. 2009 Oct;50(4):1105-12
references.pmid: 19637289
references.citation: J Appl Physiol (1985). 1992 Jun;72(6):2197-202
references.pmid: 1629073
references.citation: Obesity (Silver Spring). 2006 Jan;14(1):73-87
references.pmid: 16493125
references.citation: Arch Intern Med. 2009 Jan 26;169(2):122-31
references.pmid: 19171808
references.citation: Diabetes Care. 2004 Feb;27(2):547-52
references.pmid: 14747242
references.citation: Med Sci Sports Exerc. 2004 Aug;36(8):1301-7
references.pmid: 15292736
references.citation: PLoS One. 2012;7(5):e37887
references.pmid: 22666405
references.citation: J Gerontol A Biol Sci Med Sci. 1996 Sep;51(5):M199-205
references.pmid: 8808989
references.citation: JAMA. 2010 Nov 24;304(20):2253-62
references.pmid: 21098771