title: Is IL-33 useful to detect early stage of renal failure?
abstract: IL-33 is a proinflammatory cytokine that is a member of IL-1 family. Previously the effect of IL-33 on kidney injury is showed in animal models. In this study, we searched if we can use IL-33 to show the early stage of kidney injury in diabetic patients. Three groups are identified: 26 patients in Group 1: Healthy group, that do not have any chronic diseases and not taking any medication; 42 patients in Group 2: DM (diabetes mellitus) group without any known kidney disease and with normal kidney functions; 32 patients in Group 3: DM + MA (microalbuminuria) group that are assumed to have nephropathy. IL-33 level of DM patient group is greater than healthy group; also IL-33 level of DM + MA patient group is greater than healthy group; but there is not any difference between DM and DM + MA group. The increase in IL-33 levels in diabetic nephropathy is not associated with kidney injury but the increase could be resulting because of diabetes. So IL-33 cannot be used in early recognition of diabetic nephropathy.
authors.affiliation: Department of Endocrinology, Atatürk Education and Research Hospital , Ankara , Turkey .
authors.forename: Sedat
authors.initials: S
authors.lastname: Caner
authors.forename: Celil Alper
authors.initials: CA
authors.lastname: Usluoğulları
authors.forename: Fevzi
authors.initials: F
authors.lastname: Balkan
authors.forename: Fatih
authors.initials: F
authors.lastname: Büyükcam
authors.forename: Cafer
authors.initials: C
authors.lastname: Kaya
authors.forename: Muhammed
authors.initials: M
authors.lastname: Saçıkara
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.forename: Reyhan
authors.initials: R
authors.lastname: Ersoy
authors.forename: Bekir
authors.initials: B
authors.lastname: Çakır
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins