title: Role of leptin in autoimmune diseases.
abstract: Leptin represents a link between metabolism, nutritional status, and immune responses. Leptin is important for optimal functioning of the immune system. Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. Leptin has been shown to enhance immune reactions in autoimmune diseases that are commonly associated with inflammatory responses. Both high and low levels of leptin might contribute to autoimmune diseases. Leptin has been explored as a potential target for therapeutic development in treating autoimmune diseases. In this review, we review here the most recent advances on the role of leptin in autoimmunity and in immune-rheumatological diseases.
authors.affiliation: "Titu Maiorescu" University, Faculty of Medicine, Department of Physiology, "Dr. Ion Stoia" Center for Rheumatic Diseases, Bucharest, Romania.
authors.forename: Manole
authors.initials: M
authors.lastname: Cojocaru
authors.forename: Inimioara Mihaela
authors.initials: IM
authors.lastname: Cojocaru
authors.forename: Isabela
authors.initials: I
authors.lastname: Siloşi
authors.forename: Suzana
authors.initials: S
authors.lastname: Rogoz
keywords: autoimmune diseases; autoimmunity; leptin; pathophysiology
references.citation: Cell Mol Immunol. 2007 Feb;4(1):1-13
references.pmid: 17349207
references.citation: Rheumatology (Oxford). 2008 Apr;47(4):484-7
references.pmid: 18281689
references.citation: Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5
references.pmid: 15788534
references.citation: Immunity. 2007 Feb;26(2):143-5
references.pmid: 17307702
references.citation: J Immunol. 2001 May 15;166(10):5909-16
references.pmid: 11342605
references.citation: J Immunol. 2012 Mar 1;188(5):2070-3
references.pmid: 22291185
references.citation: Immunity. 2007 Feb;26(2):241-55
references.pmid: 17307705
references.citation: Eur Cytokine Netw. 2000 Mar;11(1):7-14
references.pmid: 10705294
references.citation: Contrib Nephrol. 2006;151:151-164
references.pmid: 16929139
references.citation: J Immunol. 2005 Jun 1;174(11):6820-8
references.pmid: 15905523
references.citation: Annu Rev Physiol. 2000;62:413-37
references.pmid: 10845097
references.citation: Endocr Regul. 2009 Oct;43(4):157-68
references.pmid: 19908934
references.citation: J Neuroimmunol. 2003 Jun;139(1-2):150-4
references.pmid: 12799033
references.citation: Circulation. 2004 May 11;109(18):2181-5
references.pmid: 15117839
references.citation: Cell Mol Immunol. 2011 May;8(3):203-12
references.pmid: 21399656
references.citation: Br J Dermatol. 2002 Aug;147(2):331-6
references.pmid: 12174107
references.citation: Joint Bone Spine. 2009 Mar;76(2):170-5
references.pmid: 19059800
references.citation: Rheumatology (Oxford). 2008 Apr;47(4):387-9
references.pmid: 18267962
references.citation: Ann Rheum Dis. 2003 Oct;62(10):913-5
references.pmid: 12972464
references.citation: Rheumatol Int. 2002 Aug;22(4):138-41
references.pmid: 12172951
references.citation: J Immunol. 2002 Jan 15;168(2):875-82
references.pmid: 11777985
references.citation: J Leukoc Biol. 2000 Oct;68(4):437-46
references.pmid: 11037963
references.citation: Life Sci. 2000 Oct 6;67(20):2433-41
references.pmid: 11065166
references.citation: J Immunol. 2005 Mar 15;174(6):3137-42
references.pmid: 15749839
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2593-6
references.pmid: 12788860
references.citation: Immunol Rev. 2012 Sep;249(1):116-34
references.pmid: 22889219
references.citation: J Gastroenterol Hepatol. 2004 Apr;19(4):429-32
references.pmid: 15012781
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2017-21
references.pmid: 18250302
references.citation: Lupus. 2010 Feb;19(2):170-4
references.pmid: 19965946
references.citation: Rheumatol Int. 2007 Aug;27(10):947-54
references.pmid: 17443329
references.citation: Tissue Antigens. 2007 Aug;70(2):87-95
references.pmid: 17610413
references.citation: Rheumatol Int. 2008 Mar;28(5):467-73
references.pmid: 18196243
references.citation: Vitam Horm. 2005;71:345-72
references.pmid: 16112274
references.citation: Diabetes. 2003 Aug;52(8):2121-8
references.pmid: 12882931
references.citation: J Autoimmun. 2006 Mar;26(2):133-7
references.pmid: 16380228
references.citation: Pak J Biol Sci. 2007 Jun 15;10(12):1984-9
references.pmid: 19093436
references.citation: J Clin Endocrinol Metab. 2010 Aug;95(8):3965-72
references.pmid: 20534769
references.citation: Clin Rheumatol. 2001;20(4):300-2
references.pmid: 11529645
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:211-7
references.pmid: 16126961