title: Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring.
abstract: Prenatal stress (PS) has been shown to be associated with anxiety. However, the underlying neurological mechanisms are not well understood. To determine the effects of PS on anxiety-like behavior in the adult offspring, we evaluated anxiety-like behavior using open field test (OFT) and elevated plus maze (EPM) in the 3-month offspring. Both male and female offspring showed a significant reduction of crossing counts in the center, total crossing counts, rearing counts and time spent in the center in the OFT, and only male offspring showed a decreased percentage of open-arm entries and open-arm time in open arms in the EPM. Additionally, expression of NR1 and NR2A subunit of N-methyl-D-aspartate receptor (NMDAR) in the hippocampus (HIP), prefrontal cortex (PFC) and striatum (STR) was studied. Our results showed that PS reduced NR1 and NR2A expression in the HIP, NR2A expression in the PFC and STR in the offspring. The altered NR1 and NR2A could have potential impact on anxiety-like behavior in the adult offspring exposed to PS.
authors.affiliation: Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, Shaanxi 710061, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Sun
authors.forename: Ning
authors.initials: N
authors.lastname: Jia
authors.forename: Lixia
authors.initials: L
authors.lastname: Guan
authors.forename: Qing
authors.initials: Q
authors.lastname: Su
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000473:pathology*; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D018782:Maze Learning / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: C409466:NR1 NMDA receptor; C120997:NR2A NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Anxiety-like behavior; NR1; NR2A; Offspring; Prenatal stress