title: Assessing the causes and consequences of co-polymerization in amyloid formation.
abstract: How, and why, different proteins form amyloid fibrils is most often studied in vitro using a single purified protein sequence. However, many amyloid diseases involve co-aggregation of different protein species, including proteins with/without post-translational modifications (e.g., different strains of PrP), proteins of different length (e.g., β₂-microglobulin and ΔN6, Aβ40, and Aβ42), sequence variants (e.g., Aβ and Aβ(ARC)), and proteins from different organisms (e.g., bovine PrP and human PrP). The consequences of co-aggregation of different proteins upon the structure, stability, species transmission and toxicity of the resulting amyloid aggregates is discussed here, including the role of co-aggregation in expanding the repertoire of oligomeric and fibrillar structures and how this can affect their biological and biophysical properties.
authors.affiliation: Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology; University of Leeds; Leeds, UK.
authors.forename: Claire J
authors.initials: CJ
authors.lastname: Sarell
authors.affiliation: Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology; University of Leeds; Leeds, UK.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Stockley
authors.affiliation: Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology; University of Leeds; Leeds, UK.
authors.forename: Sheena E
authors.initials: SE
authors.lastname: Radford
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D006801:Humans; D050505:Mutant Proteins / Q000737:chemistry*; D011498:Protein Precursors / Q000737:chemistry*; D001613:beta 2-Microglobulin / Q000737:chemistry*
chemical_list: D000682:Amyloid; D050505:Mutant Proteins; D011498:Protein Precursors; D001613:beta 2-Microglobulin
keywords: amyloid; fibril; heteropolymers; polymorph; seeding; strain
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