title: A novel bioelectrochemical sensing platform based on covalently attachment of cobalt phthalocyanine to graphene oxide.
abstract: Graphene oxide-cobalt phthalocyanine (GO-PcCo) hybrid material as a new electrocatalyst was synthesized and used successfully to fabrication of new biosensor for the electrooxidation of l-cysteine (CSH) in aqueous media. Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) images revealed that cobalt phthalocyanine is covalently attachment on graphene oxide sheets as single layers GO-PcCo. Cyclic voltammetric studies showed that the GO-PcCo/glassy carbon electrode (GO-PcCo/GCE) improves electrochemical behavior of CSH oxidation, as compared to the GO and PcCo. In addition, the results indicated that GO and PcCo have a synergic effect in the electrooxidation of CSH. The catalytic oxidation responses were studied and the reaction mechanisms were discussed. The electrocatalytic behavior is further developed as a new detection scheme for CSH by chronoamperometry method and under optimized conditions, excellent analytical features, including high sensitivity and selectivity, low detection limit and satisfactory dynamic range, were achieved.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, G. C., P.O. Box 19396-4716, Tehran, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Hosseini
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Mahyari
authors.forename: Akbar
authors.initials: A
authors.lastname: Bagheri
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002244:Carbon / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry / Q000302:isolation & purification*; D004563:Electrochemistry; D006108:Graphite / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D057230:Limit of Detection; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D010087:Oxides; D014867:Water; C063633:cobalt phthalocyanine; D002244:Carbon; D006108:Graphite; D003545:Cysteine
keywords: Biosensors; Cobalt phthalocyanine; Covalently attachment; Electrochemistry; Graphene oxide