title: The usefulness of the universal culture-based screening and the efficacy of intrapartum prophylaxis of group B Streptococcus infection.
abstract: OBJECTIVE
  To evaluate the usefulness of universal culture-based GBS screening at 35-37 weeks of gestation, assess the efficacy of intrapartum antibiotic administration (IAP) and investigate factors influencing the infection rate in neonates.
  
  
  METHODS
  Out of 1653 pregnant women 304 (18.4%) further analyzed were GBS positive directly before the delivery, among them 69 were false GBS negative on antenatal screening. Various variables regarding parturients' and newborns' characteristics were taken into account in order to achieve the objective of the study.
  
  
  RESULTS
  Out of 304 GBS-positive patients directly before the delivery, culture-based screening was positive in 72.4%, while 22.7% presented with GBS-negative screening and received no IAP. No single culture-confirmed early-onset GBS disease was observed.
  
  
  CONCLUSIONS
  IAP is an effective way of early-onset GBS disease prevention, however prenatal screening would be most efficient if performed intrapartal.
authors.affiliation: 1st Department of Obstetrics and Gynecology, Medical University of Warsaw , Warsaw , Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Szymusik
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kosinska-Kaczynska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Krolik
authors.forename: Magdalena
authors.initials: M
authors.lastname: Skurnowicz
authors.forename: Bronislawa
authors.initials: B
authors.lastname: Pietrzak
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Wielgos
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control* / Q000706:statistics & numerical data; D008403:Mass Screening / Q000379:methods; D008828:Microbiological Techniques; D036801:Parturition / Q000187:drug effects; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D011296:Prenatal Diagnosis / Q000379:methods*; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D013292:Streptococcus agalactiae / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: GBS infection; GBS screening; intrapartal screening; intrapartum antibiotic prophylaxis; neonatal infections