title: Temporal trends, clinical characteristics, and outcomes of histoplasmosis in a tertiary care center in Kentucky, 2000 to 2009.
abstract: The impact of highly active antiretroviral therapy (HAART) on the epidemiology of AIDS-associated histoplasmosis in the past decade is poorly defined. Among 100 patients with histoplasmosis in an endemic region between 2000 and 2009, 42 patients were immunocompetent, 32 were infected with HIV, and 26 were non-HIV-immunocompromised patients. The percentage with HIV decreased 67% in 2000-2001 to 18% in 2008-2009 (P = .004), while the proportion of non-HIV immunocompromised patients increased, 8% to 41% (P = .14). Histoplasma antigen was the most sensitive test (73%), whereas potassium hydroxide examination of clinical specimens was the least sensitive test (33%) in all 3 groups. Bronchoalveloar fluid culture (74%) had the highest yield among the cultures. The relapse rate was higher in HIV-infected patients compared to the other 2 groups (P = .04). The epidemiology of histoplasmosis in our endemic area has changed during the era of HAART. Organ transplantation and increasing use of immunosuppressive agents for chronic inflammatory conditions in non-HIV patients now account for most of the cases of histoplasmosis.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Kentucky, Lexington, KY, USA.
authors.forename: Thein
authors.initials: T
authors.lastname: Myint
authors.forename: Majdi N
authors.initials: MN
authors.lastname: Al-Hasan
authors.forename: Julie A
authors.initials: JA
authors.lastname: Ribes
authors.forename: Brian S
authors.initials: BS
authors.lastname: Murphy
authors.forename: Richard N
authors.initials: RN
authors.lastname: Greenberg
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000276:immunology*; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D006660:Histoplasmosis / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D017052:Hospital Mortality; D006801:Humans; D007121:Immunocompetence / Q000276:immunology*; D016867:Immunocompromised Host / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000276:immunology* / Q000627:therapeutic use; D007629:Kentucky / Q000453:epidemiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D062606:Tertiary Care Centers; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents
keywords: HIV; clinical characteristics; histoplasmosis; immunocompromised; trends