title: [Application of neurally adjusted ventilatory assist in preterm infants with respiratory distress syndrome].
abstract: OBJECTIVE
  To observe the effects of neurally adjusted ventilatory assist (NAVA) on the patient-ventilator synchrony, gas exchange, and ventilatory parameters in preterm infants with respiratory distress syndrome (RDS) during mechanical ventilation.
  
  
  METHODS
  Ten preterm infants with RDS received mechanical ventilation in NAVA mode for 60 minutes and in synchronized intermittent mandatory ventilation (SIMV) mode for 60 minutes, and the two modes were given in a random order. The vital signs, patient-ventilator synchrony, blood gas values, and ventilatory parameters were compared between the two ventilation modes.
  
  
  RESULTS
  Inspiratory trigger delay was significantly shorter with NAVA than with SIMV (P<0.05). There were no significant differences in arterial pH, PaCO2, PaO2 and PaO2/FiO2 between the two modes. The spontaneous respiratory rate, peak inspiratory pressure (PIP), electrical activity of the diaphragm and work of breathing were significantly lower in NAVA than in SIMV (P<0.05).
  
  
  CONCLUSIONS
  Compared with SIMV, NAVA appears to improve patient-ventilator synchrony, decrease PIP, and reduce diaphragmatic muscle load and work of breathing in preterm infants with RDS during mechanical ventilation.
authors.affiliation: Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China. dulizhong@yahoo.com.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Ma
authors.forename: Hui-Jia
authors.initials: HJ
authors.lastname: Lin
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Shi
authors.forename: Li-Zhong
authors.initials: LZ
authors.lastname: Du
mesh_terms: D003964:Diaphragm / Q000502:physiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012121:Respiration, Artificial / Q000379:methods*; D012125:Respiratory Center / Q000502:physiology; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*