title: Erectile dysfunction and target organ damage in the early stages of hypertension.
abstract: The authors investigated whether erectile dysfunction (ED) in the early stages of hypertension is associated with heightened end-organ damage. A total of 174 consecutive men with untreated, newly diagnosed essential hypertension (aged 50.3 years, office blood pressure [BP] 150/98 mm Hg) were studied. All participants underwent 24-hour ambulatory BP monitoring, blood examination, albumin-creatinine ratio, carotid-femoral pulse-wave velocity assessment, and echocardiography for estimation of left ventricular mass index and diastolic function. Hypertensive men with ED (n=43, 24.7%) compared with those without ED were older (by 6.4 years, P<.05), had greater 24-hour pulse pressure (by 4.3 mm Hg, P=.011) and a greater prevalence of nondipping status (72.2% vs 46.7%, P=.008), while the two groups did not differ in plasma glucose, lipid, creatinine, and albumin/creatinine ratio levels. Regarding cardiac adaptations, hypertensive men with ED exhibited only significantly lower tissue Doppler imaging-derived Em (by 1.6 cm/s, adjusted P=.035), while no difference in left ventricular mass index or pulse wave velocity were detected. ED in the setting of untreated newly diagnosed essential hypertension does not have an unfavorable impact on traditional markers of target organ damage. This finding suggests that ED assessment might not refine the traditional risk stratification procedure at least in the early stages of hypertensive disease.
authors.affiliation: Cardiology Department, Hippocration Hospital, Athens, Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Kakkavas
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tsiachris
authors.forename: Costas
authors.initials: C
authors.lastname: Thomopoulos
authors.forename: Kyriakos
authors.initials: K
authors.lastname: Dimitriadis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Milkas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Alexopoulos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kallikazaros
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D018450:Disease Progression; D007172:Erectile Dysfunction / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012307:Risk Factors; D018608:Ultrasonography, Doppler
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