title: Prognostic factors of carcinoma of the ampulla of Vater after surgery.
abstract: The purpose of this study was to investigate the prognostic factors of carcinoma of the ampulla of Vater (CAV) after surgery. The clinicopathological factors related to the recurrence and prognosis of 162 CAV patients after surgical resection were retrospectively analyzed using univariate and multivariate methods. The in-hospital mortality rate was 4.32 % and the 5-year disease-free survival and overall survival of the 162 subjects were 55.1 and 51.7 %, respectively. Univariate analysis revealed that an advanced T stage (P = 0.002), lymph nodal metastasis (P = 0.002), poor differentiation (P = 0.006), tumor size (P = 0.033), tumor stage (P = 0.001), carbohydrate antigen (CA) 199 serum levels (P = 0.000), pancreatic invasion (P = 0.001), chemotherapy/radiation therapy (P = 0.006), and jaundice (P = 0.012) were factors that significantly affected the prognosis of CAV. Multivariate analysis showed that the pancreatic invasion (P = 0.009), lymph nodal metastasis (P = 0.009), and increased CA199 serum level (P = 0.001) were independent risk factors of recurrence. The pancreatic invasion, lymph nodal metastasis, and increased CA199 serum level are key prognostic factors of CAV after surgery.
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, South Panjiayuan Rd, Beijing, 100021, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhou
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Shan
authors.forename: Dongbing
authors.initials: D
authors.lastname: Zhao
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology* / Q000601:surgery; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000097:blood / Q000150:complications / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C578959:carbohydrate antigen 199, human
references.citation: J Gastrointest Oncol. 2012 Jun;3(2):97-104
references.pmid: 22811877
references.citation: Curr Opin Gastroenterol. 2010 May;26(3):280-5
references.pmid: 20168227
references.citation: Biotechnol Lett. 2012 Jul;34(7):1235-41
references.pmid: 22456901
references.citation: J Gastrointest Surg. 2010 Feb;14(2):379-87
references.pmid: 19911239
references.citation: Ann Surg Oncol. 2008 Jul;15(7):1820-7
references.pmid: 18369675
references.citation: J Thorac Dis. 2012 Oct;4(5):446-7
references.pmid: 23050102
references.citation: Radiother Oncol. 2009 Aug;92(2):244-8
references.pmid: 19541379
references.citation: Ann Surg Oncol. 2007 Jan;14(1):50-60
references.pmid: 17054003
references.citation: Ann Surg. 2005 Jul;242(1):92-100
references.pmid: 15973106
references.citation: J Hepatobiliary Pancreat Surg. 2008;15(4):423-8
references.pmid: 18670845
references.citation: Mol Biotechnol. 2012 Sep;52(1):59-67
references.pmid: 22382453
references.citation: Surgery. 2000 Jun;127(6):628-33
references.pmid: 10840357
references.citation: J Gastrointest Surg. 2012 Nov;16(11):2056-63
references.pmid: 22914983
references.citation: Gastrointest Endosc. 2006 May;63(6):783-8
references.pmid: 16650538
references.citation: Gastrointest Endosc Clin N Am. 1997 Jul;7(3):387-99
references.pmid: 9177141
references.citation: Chin J Cancer Res. 2012 Sep;24(3):220-5
references.pmid: 23358703
references.citation: Arch Surg. 1999 May;134(5):526-32
references.pmid: 10323425
references.citation: Dig Surg. 2010;27(2):115-8
references.pmid: 20551654
references.citation: World J Surg Oncol. 2006 Mar 08;4:14
references.pmid: 16524478
references.citation: World J Surg. 2005 May;29(5):649-52
references.pmid: 15827855
references.citation: J Surg Oncol. 2009 Jul 1;100(1):19-24
references.pmid: 19384907
references.citation: Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):945-53
references.pmid: 10863064
references.citation: Gastrointest Endosc. 2007 Oct;66(4):701-7
references.pmid: 17905011
references.citation: Surgery. 2006 Nov;140(5):764-72
references.pmid: 17084719
references.citation: Anticancer Res. 2013 Jun;33(6):2715-21
references.pmid: 23749931
references.citation: World J Surg. 2007 Jan;31(1):137-43; discussion 144-6
references.pmid: 17171495
references.citation: Int Semin Surg Oncol. 2005 Aug 30;2:16
references.pmid: 16131399
references.citation: J Gastrointest Surg. 2010 Apr;14(4):719-28
references.pmid: 20107918
references.citation: Arch Surg. 2003 Sep;138(9):941-8; discussion 948-50
references.pmid: 12963649
references.citation: Ann Surg Oncol. 2010 Apr;17(4):991-7
references.pmid: 20108122
references.citation: Radiat Oncol. 2011 Sep 28;6:126
references.pmid: 21951377