title: The two sides of HER2/neu: immune escape versus surveillance.
abstract: The oncogene HER2 is one of the prototypes for targeted immunotherapy of cancer using both monoclonal antibodies as well as T cell based immunotherapies. Effective humoral and cellular immune responses against HER2 can be induced, but these responses can be influenced by the effects of this oncogene on the target tumor cells. The processes involved in HER2-mediated adaptive and innate immunity and the molecular mechanisms underlying the escape of HER2-expressing tumor cells from immune surveillance, particularly from cytotoxic T cells, are discussed. Implementing this knowledge in clinical trials to revert immune evasion may help optimize immunotherapies directed against HER2-expressing tumors.
authors.affiliation: University Halle-Wittenberg, Institute of Medical Immunology, Magdeburger Str. 2, 06112 Halle (Saale), Germany. Electronic address: Barbara.Seliger@uk-halle.de.
authors.forename: Barbara
authors.initials: B
authors.lastname: Seliger
authors.forename: Rolf
authors.initials: R
authors.lastname: Kiessling
mesh_terms: D000818:Animals; D006801:Humans; D007157:Immunologic Surveillance; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000276:immunology*; D019139:Tumor Escape
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases
keywords: HER2; HLA; immune escape; immunotherapy; tumor