title: Relationship between plasma fibrinogen levels and pulmonary function in the japanese population: the Takahata study.
abstract: BACKGROUND
  Plasma fibrinogen is considered a biomarker of respiratory disease, owing to the relationship between plasma fibrinogen and pulmonary function established in Western populations. However, such a relationship has not yet been confirmed in an Asian population. We assessed this relationship in the general Japanese population.
  
  
  METHODS
  Totally, 3,257 men and women aged ≥40 years who participated in a community-based annual health checkup in Takahata, Japan, from 2004 to 2006, underwent spirometry, and their plasma fibrinogen levels were determined.
  
  
  RESULTS
  We found an inverse relationship between spirometric measures (percent predicted forced vital capacity [%FVC] and forced expiratory volume in 1s [%FEV1], and FEV1/FVC) and plasma fibrinogen levels in men, but not in women. The plasma fibrinogen levels were significantly higher in subjects with restrictive, obstructive, and mixed ventilatory disorders than in those with normal spirometry results. Multiple linear regression analysis revealed that in men, plasma fibrinogen levels were predictive for %FVC and %FEV1 (independent of age, body mass index, and cigarette smoking) but not for FEV1/FVC.
  
  
  CONCLUSIONS
  Plasma fibrinogen was significantly associated with pulmonary function in Japanese men, and as such, plasma fibrinogen might be a potent biomarker for pulmonary dysfunction in men.
authors.affiliation: 1. Department of Cardiology, Pulmonology, and Nephrology;
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishi
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.forename: Kento
authors.initials: K
authors.lastname: Sato
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kimura
authors.forename: Takako
authors.initials: T
authors.lastname: Nemoto
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D044466:Asian People; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology
chemical_list: D005340:Fibrinogen
keywords: Chronic Obstructive Pulmonary Disease; Decline in FEV1; Fibrinogen; Pulmonary function; Smoker; Spirometry
references.citation: N Engl J Med. 2011 Sep 29;365(13):1184-92
references.pmid: 21991892
references.citation: Nihon Kokyuki Gakkai Zasshi. 2004 Nov;Suppl:1-56
references.pmid: 15565748
references.citation: Biochem Biophys Res Commun. 2011 Nov 18;415(2):284-7
references.pmid: 22027142
references.citation: Intern Med. 2010;49(15):1489-99
references.pmid: 20686279
references.citation: Thorax. 2013 Jul;68(7):670-6
references.pmid: 22744884
references.citation: Nat Genet. 2010 Jan;42(1):36-44
references.pmid: 20010834
references.citation: Int J Chron Obstruct Pulmon Dis. 2012;7:173-82
references.pmid: 22419864
references.citation: Am J Respir Crit Care Med. 2011 Jan 1;183(1):43-9
references.pmid: 20709820
references.citation: Am J Respir Crit Care Med. 2012 Nov 15;186(10):982-8
references.pmid: 22983959
references.citation: Am J Respir Crit Care Med. 2001 Sep 15;164(6):1008-11
references.pmid: 11587987
references.citation: Circ Cardiovasc Genet. 2009 Apr;2(2):134-41
references.pmid: 20031577
references.citation: Am J Pathol. 2000 Sep;157(3):703-8
references.pmid: 10980108
references.citation: PLoS Genet. 2009 Mar;5(3):e1000421
references.pmid: 19300482
references.citation: Semin Immunopathol. 2012 Jan;34(1):43-62
references.pmid: 22037947
references.citation: Eur Respir J. 2009 May;33(5):1165-85
references.pmid: 19407051
references.citation: Int J Med Sci. 2013;10(1):1-7
references.pmid: 23288999
references.citation: Eur Respir J. 2013 Jul;42(1):18-27
references.pmid: 23143543
references.citation: Am J Med. 2003 Jun 15;114(9):758-62
references.pmid: 12829203
references.citation: BMC Med Genet. 2009 Mar 09;10:23
references.pmid: 19272152
references.citation: JAMA. 2005 Oct 12;294(14):1799-809
references.pmid: 16219884
references.citation: Int J Med Sci. 2011;8(7):514-22
references.pmid: 21897765
references.citation: Thorax. 2011 Dec;66(12):1085-90
references.pmid: 21921092
references.citation: Am J Respir Crit Care Med. 2012 Oct 1;186(7):622-32
references.pmid: 22837378
references.citation: Atherosclerosis. 2003 Aug;169(2):203-14
references.pmid: 12921971
references.citation: J Clin Invest. 2000 Dec;106(11):1341-50
references.pmid: 11104787
references.citation: Curr Opin Hematol. 2012 Sep;19(5):349-56
references.pmid: 22759629
references.citation: Int J Med Sci. 2011;8(6):470-8
references.pmid: 21850198
references.citation: PLoS One. 2010 Jul 02;5(7):e11431
references.pmid: 20625390
references.citation: Hum Mol Genet. 2012 Feb 15;21(4):947-57
references.pmid: 22080838
references.citation: Intern Med. 2011;50(21):2547-55
references.pmid: 22041355
references.citation: Chest. 2005 Sep;128(3):1475-82
references.pmid: 16162746
references.citation: Ann N Y Acad Sci. 2001;936:542-8
references.pmid: 11460513
references.citation: Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Dec;32 Suppl:187-92
references.pmid: 7602830
references.citation: Intern Med. 2011;50(2):87-93
references.pmid: 21245630
references.citation: Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):494-9
references.pmid: 21325671
references.citation: J Thromb Thrombolysis. 2008 Oct;26(2):97-102
references.pmid: 17622488