title: Age-specific Mycoplasma pneumoniae pneumonia-associated myocardial damage in children.
abstract: OBJECTIVE
  To measure Mycoplasma pneumoniae pneumonia (MPP)-associated myocardial damage in different age groups of children with pneumonia.
  
  
  METHODS
  Children aged 0-14 years with pneumonia and myocardial damage (serum creatine kinase isoenzyme-MB [CK-MB] concentration >25 U/l) were enrolled in the study. The children were classified as Mycoplasma pneumoniae immunoglobulin M positive (M. pneumoniae IgM+) or negative (M. pneumoniae IgM-) based on a serological test. Children were stratified into four age groups in order to analyse age-specific MPP-associated myocardial damage.
  
  
  RESULTS
  The incidence of fever was significantly higher in children who were M. pneumoniae IgM+ compared with M. pneumoniae IgM- children. The median serum CK-MB concentration was significantly higher in children who were M. pneumoniae IgM+ compared with those who were M. pneumoniae IgM-. Children who were M. pneumoniae IgM+ in the 13-36 months and 72 months-14 years age groups had significantly higher median serum CK-MB concentrations than those who were M. pneumoniae IgM- in the same age group.
  
  
  CONCLUSIONS
  M. pneumoniae infection was associated with greater myocardial damage in children aged 13-36 months and 72 months-14 years. This suggests age-specific immune responses to M. pneumoniae.
authors.affiliation: Department of Paediatrics, Tenth People's Hospital, Tongji University, Shanghai, China.
authors.forename: Cheng-Mei
authors.initials: CM
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Gu
authors.forename: Shao-Jun
authors.initials: SJ
authors.lastname: Yin
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Xiao-Zhi
authors.initials: XZ
authors.lastname: Guo
authors.forename: Yu-Xuan
authors.initials: YX
authors.lastname: Fu
authors.forename: Dan
authors.initials: D
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D005334:Fever / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009177:Mycoplasma pneumoniae / Q000472:pathogenicity* / Q000502:physiology; D009205:Myocarditis / Q000097:blood / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D012720:Severity of Illness Index
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D052279:Creatine Kinase, MB Form
keywords: Mycoplasma pneumoniae; age; immune system; infection; myocardial injury