title: Design, preparation, and implementation of an imidazole-based chiral biaryl P,N-ligand for asymmetric catalysis.
abstract: A new strategy for increasing the barrier to rotation in biaryls has been developed that allows for the incorporation of 5-membered aromatic heterocycles into chiral atropisomers. Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a single enantiomer. This ligand performs exceptionally well in the enantioselective A(3)-coupling, demonstrating the potential of this new design element.
authors.affiliation: Department of Chemistry, University of Florida , P.O. Box 117200, Gainesville, Florida 32611, United States.
authors.forename: Flavio S P
authors.initials: FS
authors.lastname: Cardoso
authors.forename: Khalil A
authors.initials: KA
authors.lastname: Abboud
authors.forename: Aaron
authors.initials: A
authors.lastname: Aponick