title: Impulsivity, cognitive function, and their relationship in heroin-dependent individuals.
abstract: There is mixed evidence concerning cognitive function and heroin dependence. In this study, abstinent heroin-dependent individuals (n = 86) and age- and sex-matched non-drug-using controls (n = 88) were compared on self-report measures of impulsivity and computerized assessments of cognitive function. Abstinent heroin-dependent individuals reported greater motor impulsivity and experience seeking and showed functional weaknesses in cognitive ability, including impulsivity and distractibility (d = 0.28 to 0.49), but not decision making or working memory. Self-reported impulsivity was uncorrelated with cognitive function. These results suggest underlying brain-related factors in heroin dependence and have implications for therapeutic intervention.
authors.affiliation: a The Research Center of Psychology & Brain Science , Guangzhou University , Guangzhou , China.
authors.forename: H
authors.initials: H
authors.lastname: Zeng
authors.forename: Tatia M C
authors.initials: TM
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Waters
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
authors.forename: Pak C
authors.initials: PC
authors.lastname: Sham
authors.forename: R S
authors.initials: RS
authors.lastname: Schottenfeld
authors.forename: C
authors.initials: C
authors.lastname: Marienfeld
authors.forename: Marek C
authors.initials: MC
authors.lastname: Chawarski
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D055030:Drug Users / Q000523:psychology*; D005260:Female; D006556:Heroin Dependence / Q000150:complications / Q000523:psychology*; D006801:Humans; D007175:Impulsive Behavior / Q000150:complications / Q000523:psychology*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D057566:Self Report