title: Platelet aggregation in rhesus macaques (Macaca mulatta) in response to short-term meloxicam administration.
abstract: NSAID administration is often chosen as a method of minimizing pain and discomfort for nonhuman primates. Of concern when using NSAID is the potential for decreased platelet aggregation due to the inhibition of cyclooxygenases 1 and 2. In both dogs and humans, the use of NSAID that are selective for cyclooxygenase 2, like meloxicam, minimizes the inhibition of platelet aggregation in comparison to nonselective NSAID, like aspirin, that inhibit both isoforms of cyclooxygenase. In this study, we measured platelet aggregation in rhesus macaques (n = 6) by using the impedance method on a multiple-electrode aggregometer at baseline, at 1 and 4 d after initiating treatment with aspirin or meloxicam, and after a washout period. There was no statistical difference between aggregation at baseline and after 1 or 4 d of meloxicam treatment, but platelet aggregation decreased after both 1 and 4 d of aspirin therapy. Our data suggest that clinically significant postoperative hemorrhage is unlikely in rhesus macaques briefly treated with meloxicam.
authors.affiliation: University of California, San Francisco, Laboratory Animal Resource Center, San Francisco, California, USA.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Anderson
authors.forename: Jamie
authors.initials: J
authors.lastname: Austin
authors.forename: Evelyn P
authors.initials: EP
authors.lastname: Escobar
authors.forename: Larry
authors.initials: L
authors.lastname: Carbone
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D016718:Arachidonic Acid / Q000378:metabolism; D001241:Aspirin / Q000008:administration & dosage*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D000077239:Meloxicam; D010149:Postoperative Pain / Q000378:metabolism / Q000517:prevention & control* / Q000662:veterinary*; D010974:Platelet Aggregation / Q000187:drug effects*; D013045:Species Specificity; D013843:Thiazines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; D016718:Arachidonic Acid; D001241:Aspirin; D000077239:Meloxicam
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