title: Platelet cytoskeleton and its hemostatic role.
abstract: Upon vascular injury, platelets adhere to the exposed extracellular matrix, which triggers the platelet activation and aggregation to form a hemostatic plug to seal the wound. All of these events involve dramatic changes in shape because of the cytoskeleton reorganization. The versatility of the cytoskeleton's main elements depends on the biochemical nature of the elements, as well as on the associated proteins that confer multiple functions within the cell. The list of these associated proteins grows actively, increasing our knowledge concerning the complexity of platelet cytoskeleton machinery. The present review evidences the recently described platelet proteins that promote characteristic modifications in their cytoskeleton organization, with special focus on the dystrophin-glycoprotein complex.
authors.affiliation: Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional (IPN), México City, México.
authors.forename: Doris
authors.initials: D
authors.lastname: Cerecedo
mesh_terms: D001792:Blood Platelets / Q000502:physiology / Q000648:ultrastructure; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D049030:Dystroglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016189:Dystrophin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology; D010973:Platelet Adhesiveness / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D055503:Protein Multimerization; D049031:Sarcoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; C484258:DMD protein, human; D016189:Dystrophin; D049031:Sarcoglycans; D049030:Dystroglycans