title: A biosynthetic pathway of sesquiterpene lactones in Smallanthus sonchifolius and their localization in leaf tissues by MALDI imaging.
abstract: The biosynthetic route for epoxyangelate esters of the sesquiterpene lactones (STL) uvedalin and enhydrin from in vitro cultures of Smallanthus sonchifolius (Asteraceae) was investigated with (13)C-precursors for the first time in the literature. Photomicroscope analyses and studies using MALDI-MS imaging confirmed that glandular trichomes accumulate STL.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto/Núcleo de Pesquisa em Produtos Naturais e Sintéticos, Universidade de São Paulo, Avenida do Café s/n, 14040-903, Brazil. mtpupo@fcfrp.usp.br.
authors.forename: Adriana A
authors.initials: AA
authors.lastname: Lopes
authors.forename: Edieidia S
authors.initials: ES
authors.lastname: Pina
authors.forename: Denise B
authors.initials: DB
authors.lastname: Silva
authors.forename: Ana Maria S
authors.initials: AM
authors.lastname: Pereira
authors.forename: Maria Fátima das G F
authors.initials: MF
authors.lastname: da Silva
authors.forename: Fernando B
authors.initials: FB
authors.lastname: Da Costa
authors.forename: Norberto P
authors.initials: NP
authors.lastname: Lopes
authors.forename: Mônica T
authors.initials: MT
authors.lastname: Pupo
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D053898:Biosynthetic Pathways; D002478:Cells, Cultured; D004952:Esters / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D004952:Esters; D007783:Lactones; D012717:Sesquiterpenes; C521984:enhydrin