title: Cholera toxin notches epithelial junctions.
abstract: Cholera toxin (CT) is the factor responsible for watery diarrhea associated with Vibrio cholerae infection. In this issue, Guichard et al. (2013) report that CT compromises intestinal epithelium barrier function via cyclic AMP (cAMP)-induced disruption of Rab11- and exocyst-dependent delivery of endocytic recycling cargo to cell-cell junctions.
authors.affiliation: Inserm U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Université de Nice-Sophia Antipolis, 151 Route St Antoine de Ginestière, BP 2 3194, 06204 Nice Cedex, France. Electronic address: lemichez@unice.fr.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lemichez
authors.forename: Caroline
authors.initials: C
authors.lastname: Stefani
mesh_terms: D000818:Animals; D002772:Cholera Toxin / Q000378:metabolism*; D004847:Epithelial Cells / Q000502:physiology*; D055354:Exosomes / Q000187:drug effects*; D054884:Host-Pathogen Interactions; D006801:Humans; D062725:Tight Junction Proteins / Q000037:antagonists & inhibitors*; D019108:Tight Junctions / Q000502:physiology*; D014734:Vibrio cholerae / Q000502:physiology*
chemical_list: D062725:Tight Junction Proteins; D002772:Cholera Toxin