title: Inhibition of hepatitis C virus infection by polyoxometalates.
abstract: Hepatitis C virus (HCV) infects about 2% of the world population. The standard treatment of chronic HCV infection is still discontented because of the low sustained virological response rate. The development of new HCV antivirals is a healthcare imperative. We explored the potentials of polyoxometalates to inhibit HCV infection using newly developed HCVcc cell culture system. We found one polyoxometalate compound (named POM-12) can inhibit HCV infection at the nanomolar range while displayed little cytotoxicity. We showed that POM-12 inhibited pseudotyped HCV infection but had no effect on HCV RNA replication. Furthermore, we showed that POM-12 was virucidal and can disrupt HCV particles. Finally we demonstrated that POM-12 had no effect on the vesicular stomatitis virus infection while had weak inhibitory activity against the influenza virus infection. In conclusion, we identified a potent anti-HCV compound which may provide an attractive drug candidate to cure HCV infection.
authors.affiliation: Department of Hepatology, First Hospital, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiang
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Qi
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Junqi
authors.initials: J
authors.lastname: Niu
authors.forename: Jin
authors.initials: J
authors.lastname: Zhong
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects; D017973:Tungsten Compounds / Q000494:pharmacology*; D018116:Vesiculovirus / Q000187:drug effects; D053586:Virus Internalization / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D000099294:Polyoxometalates
chemical_list: D000998:Antiviral Agents; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: Antiviral; Hepatitis C virus; Polyoxometalate; Virucidal