title: Development of allergic bronchopulmonary aspergillosis with central bronchiectasis over a 10-year period: the need to recheck allergen sensitization.
abstract: A 55-year-old woman visited our hospital for an investigation of central bronchiectasis, mucoid impaction and infiltrative shadows on chest CT. She had a 10-year history of bronchial asthma; however, her adherence to treatment was poor. Based on the presence of peripheral blood eosinophilia and immediate cutaneous reactivity to Aspergillus fumigatus, the patient was clinically diagnosed with allergic bronchopulmonary aspergillosis. Her condition and CT findings improved with systemic corticosteroid therapy. It was found that the patient had not been sensitized to Aspergillus 10 years earlier, indicating that single testing is inadequate for the early diagnosis of this disease.
authors.affiliation: Department of Respiratory Medicine, Shizuoka General Hospital, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shirai
authors.forename: Masashi
authors.initials: M
authors.lastname: Mikamo
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Shishido
authors.forename: Takefumi
authors.initials: T
authors.lastname: Akita
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Asada
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000485:Allergens / Q000276:immunology; D000908:Antibodies, Fungal / Q000097:blood; D000946:Antigens, Fungal / Q000276:immunology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D001232:Aspergillus fumigatus / Q000276:immunology; D001249:Asthma / Q000150:complications / Q000276:immunology; D001987:Bronchiectasis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E / Q000097:blood; D008875:Middle Aged; D012882:Skin Tests; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000485:Allergens; D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D007073:Immunoglobulin E