title: Paget's Disease. A Case Report.
abstract: Paget's disease (PD) is a common focal progressive osteometabolic disorder characterised by a disturbance in bone modelling and remodelling, because of an increase in osteoblastic and osteoclastic activity. It is a condition of unknown aetiology affecting approximately 3% of the population over 40 years of age and, approximately 10% of those over the age of 85 years. It is most common in Northern Europe and Australia and is rare in Asia and Africa. We describe the case of a 71-year-old man diagnosed with PD confined to the sacrum. After laboratory test, an imaging study with radiography, scintigraphy, computed tomography (CT) and magnetic resonance imaging (MRI) was performed disclosing findings compatible with Paget's disease in middle pathologic phase. The diagnosis was confirmed at biopsy. The structural modification of the sacrum with spongiosa rarefaction, thickening of bone and intact bone cortical, confirmed by CT, are tipical of an intermediate phase of PD. This was also supported by signal MRI changes showing substitution of the red by the fat medulla, visualized by FS sequences. Once the treatment for the bone disease was established, the patient no longer complained of pain. Special attention should be paid to male and elderly patients with pain in the lumbar spine because of the potential risk cancer development (21). The radiologist must be attentive to the possible presentations and complications of PD, even in uncommon sites, trying whenever possible to correlate the radiological features with the patient's clinical symptoms.
authors.affiliation: Magrassi Lanzara Department, Second University of Naples; Naples, Italy - rosario82rg@hotmail.it.
authors.forename: R
authors.initials: R
authors.lastname: Conforti
authors.forename: R
authors.initials: R
authors.lastname: Galasso
authors.forename: V
authors.initials: V
authors.lastname: Marrone
authors.forename: L
authors.initials: L
authors.lastname: Urciuoli
authors.forename: S
authors.initials: S
authors.lastname: Cirillo