title: Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort.
abstract: BACKGROUND
  The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers.
  
  
  METHODS
  Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA).
  
  
  RESULTS
  BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04).
  
  
  CONCLUSIONS
  Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.
authors.affiliation: Department of Neurobiology, Care Sciences and Society, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Milica Gregoric
authors.initials: MG
authors.lastname: Kramberger
authors.forename: Ingemar
authors.initials: I
authors.lastname: Kåreholt
authors.forename: Thomas
authors.initials: T
authors.lastname: Andersson
authors.forename: Bengt
authors.initials: B
authors.lastname: Winblad
authors.forename: Maria
authors.initials: M
authors.lastname: Eriksdotter
authors.forename: Vesna
authors.initials: V
authors.lastname: Jelic
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis*; D015331:Cohort Studies; D003704:Dementia / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D015233:Models, Statistical; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins