title: Severe generalized muscular atrophia, nerve optic atrophia, ear problem and disability with Pelger-Huet anomaly.
abstract: BACKGROUND
  The Pelger-Huet anomaly dominantly is a rare and benign inherited defect of terminal neutrophil differentiation. Although neutrophil migration may be minimally impaired, granulocytes function is otherwise normal association abnormalities such as ocular, musculoskeletal are reported very rare. Case Presentation : An eight year-old boy with good consciousness but severe muscular atrophia and difficulty in respiration was admitted in Amirkola Hospital at Babol University of Medical Sciences Babol, Iran. The patient was febrile at presentation. The chest x-ray was normal and other causes of respiratory problem were ruled out. The patient and his mother have 30% to 40% band and Pelger-Huet cells in peripheral blood smear. He gradually has gotten hearing loss and decreased visual acuity for three years. He has optic nerve atrophia.
  
  
  CONCLUSIONS
  The patient is an unusual type of Pelger-Huet anomaly with multiple organ dysfunctions probably due to simultaneous muscular degenerative disease.
authors.affiliation: Non-Communicable Pediatrics Disease Research center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Mahmoodi Nesheli
authors.forename: Naimeh
authors.initials: N
authors.lastname: Nakhjavani
authors.forename: Tahere
authors.initials: T
authors.lastname: Galini Moghaddam
keywords: Muscular atrophia; Optic nerve atrophia.; Pelger-Huet anomaly
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