title: Single-walled carbon nanotubes mediated targeted tamoxifen delivery system using aspargine-glycine-arginine peptide.
abstract: An aspargine-glycine-arginine (NGR) peptide modified single-walled carbon nanotubes (SWCNTs) system, developed by a simple non-covalent approach, could be loaded with the anticancer drug tamoxifen (TAM). This TAM-loaded NGR modified SWCNTs (TAM/NGR-SWCNTs) not only retained both optical properties of SWCNTs and cytotoxicity of TAM, but also could accumulate in tumors and enter into 4T1 cells, which facilitated combination chemotherapy with photothermal therapy in one targeting system. Enhanced cellular uptake, antitumor effect and cell apoptosis of TAM/NGR-SWCNTs on 4T1 cells were observed in vitro, compared with the TAM solution, TAM/SWCNTs and photothermal therapy alone. In vivo investigation of TAM/NGR-SWCNTs in tumor-bearing mice further confirmed that this system possessed much higher tumor targeting capacity and antitumor efficacy than the control, especially with the near-infrared-laser irradiation treatment. Moreover, it demonstrated negligible systematic toxicity through the histopathological analysis. All these results suggest TAM/NGR-SWCNTs are promising for high targeted efficiency and treatment efficacy and low side effects of future cancer therapy by synergistic effect of chemo-photothermal combination.
authors.affiliation: The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China and.
authors.forename: Chengqun
authors.initials: C
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Hongling
authors.initials: H
authors.lastname: Zhang
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Zhang
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Jia
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D010789:Phototherapy / Q000379:methods; D013499:Surface Properties; D013629:Tamoxifen / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004337:Drug Carriers; C526428:NGR peptide; D037742:Nanotubes, Carbon; D009842:Oligopeptides; D013629:Tamoxifen