title: Single-nucleotide polymorphisms of GPX1 and MnSOD and susceptibility to bladder cancer: a systematic review and meta-analysis.
abstract: Reactive oxygen species-related damage plays a critical role in carcinogenesis. Glutathione peroxidase 1 (GPX1) and mitochondrial superoxide dismutase (MnSOD) are two key antioxidant enzymes in the defense system against reactive oxygen species. This systematic review and meta-analysis was designed to evaluate the association of single-nucleotide polymorphisms in GPX1 and MnSOD genes with susceptibility to bladder cancer risk. Online databases of PubMed, Embase, China National Knowledge Infrastructure, and SinoMed were searched to identify eligible studies. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimated the association strength. The fixed effects model and random effects model were used to pool the data from different studies. By pooling all eligible studies, we found that the GPX1 Pro198Leu polymorphism was associated with a significantly increased risk of bladder cancer (Leu vs. Pro, OR = 2.111, 95% CI = 1.020-4.368, heterogeneity (p < 0.001); LeuPro/LeuLeu vs. ProPro, OR = 1.876, 95% CI = 1.011-3.480, heterogeneity (p < 0.001)). No significant association of MnSOD Ala-9Val polymorphism with cancer risk was observed (AlaVal/ValVal vs. AlaAla, OR = 0.966, 95% CI = 0.754-1.239, heterogeneity (p = 0.390); Vla vs. Ala, OR = 1.038, 95% CI = 0.782-1.377, heterogeneity (p = 0.015)). This systematic review and meta-analysis demonstrated that the GPX1 Pro198Leu polymorphism significantly increased susceptibility to bladder cancer, while the MnSOD Ala-9Val polymorphism was not associated with bladder cancer risk.
authors.affiliation: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 1630 Dongfang Rd, Shanghai, 200127, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Cao
authors.forename: Xin
authors.initials: X
authors.lastname: Mu
authors.forename: Chen
authors.initials: C
authors.lastname: Jiang
authors.forename: Guoliang
authors.initials: G
authors.lastname: Yang
authors.forename: Haige
authors.initials: H
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003062:Codon; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000208:ethnology / Q000235:genetics*; D000094765:Glutathione Peroxidase GPX1
chemical_list: D003062:Codon; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human
references.citation: Acta Histochem. 2010 Jul;112(4):364-71
references.pmid: 19500819
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000100
references.pmid: 19621070
references.citation: Minerva Urol Nefrol. 2011 Sep;63(3):183-90
references.pmid: 21993316
references.citation: Carcinogenesis. 2004 Jun;25(6):973-8
references.pmid: 14729580
references.citation: Science. 1999 Mar 5;283(5407):1482-8
references.pmid: 10066162
references.citation: Semin Urol. 1992 Feb;10(1):39-44
references.pmid: 1565903
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1552-4
references.pmid: 21586620
references.citation: Cell Mol Life Sci. 2000 Dec;57(13-14):1825-35
references.pmid: 11215509
references.citation: Methods Enzymol. 2002;349:331-41
references.pmid: 11912924
references.citation: J Urol. 2004 Aug;172(2):728-32
references.pmid: 15247771
references.citation: Ann Oncol. 2007 Jul;18(7):1230-42
references.pmid: 17496311
references.citation: J Toxicol Environ Health. 1994 Oct;43(2):239-49
references.pmid: 7932852
references.citation: Carcinogenesis. 2007 Feb;28(2):414-22
references.pmid: 16956909
references.citation: Oncol Res. 2010;18(8):395-400
references.pmid: 20441054
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 May;9(5):461-7
references.pmid: 10815690
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2004;83:1-1438
references.pmid: 15285078
references.citation: Int Urol Nephrol. 2007;39(4):1043-8
references.pmid: 17340208
references.citation: Med Oncol. 2012 Sep;29(3):1928-34
references.pmid: 21904836
references.citation: World J Urol. 2004 Feb;21(6):392-401
references.pmid: 14685762
references.citation: Histol Histopathol. 1997 Apr;12(2):525-35
references.pmid: 9151141
references.citation: Pharmacogenet Genomics. 2005 May;15(5):311-9
references.pmid: 15864132
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):753-4
references.pmid: 15767364