title: Mycoplasma synoviae infection on Newcastle disease vaccination of chickens.
abstract: Newcastle disease is characterized by respiratory manifestations in association with nervous and/or digestive symptoms. Its prevention is done by vaccination with live attenuated (lentogenic strains) and/or killed vaccines. The lentogenic strains can lead to strong post-vaccination reaction, principally due to the presence of other pathogenic agents. Among them, Mycoplasma synoviae is worldwide important, mainly in Brazil. The dissemination of this agent in poultry flocks has been achieved due to difficulties in diagnosis and disease reproduction, virulence variations among different M.synoviae strains, and attribution of typical M.synoviae disease manifestation to other disease agents. This experimental study in SPF chicks (Gallus gallus), previously infected by M.synoviae and thereafter vaccinated against Newcastle disease, was done with the objective of evaluating M.synoviae pathogenicity through assessment of post-vaccinal respiratory reactions and serologic responses to Newcastle disease virus vaccine in the absence of environmental factors. A total of 86 three days old chicks were used, being 57 infected by eye and nostril drop, with chicken activated M. synoviae strain WVU 1853. Seven days later, 21 mycoplasma infected birds plus 29 not mycoplasma infected ones were vaccinated against Newcastle disease. As results, the not infected and vaccinated birds yielded, significantly, higher and longer lasting serologic responses to Newcastle disease vaccine virus than those infected and vaccinated. Similarly, the infected and vaccinated birds yielded lower serologic reactions to M.synoviae than those only mycoplasma infected. No post-vaccinal respiratory reaction was observed in the vaccinated birds.
authors.affiliation: Laboratório de Biologia Animal, Empresa de Pesquisa Agropecuária do Estado do Rio de Janeiro , Niterói, RJ , Brasil ;
authors.forename: Rita
authors.initials: R
authors.lastname: de Cássia Figueira Silva
authors.forename: Elmiro Rosendo
authors.initials: ER
authors.lastname: do Nascimento
authors.forename: Virgínia Léo
authors.initials: VL
authors.lastname: de Almeida Pereira
authors.forename: Maria Lúcia
authors.initials: ML
authors.lastname: Barreto
authors.forename: Maria da Graça Fichel
authors.initials: Mda G
authors.lastname: do Nascimento
keywords: Mycoplasma; Newcastle disease; serology; vaccine
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