title: Hypopigmented micropapules in apparently quiescent morphea lesions: a manifestation of disease activity.
abstract: We present two young patients with morphea or localized scleroderma undergoing systemic treatment, who developed papular lesions on pre-existing sclerotic plaques. Histology was compatible with a papular presentation of morphea and other entities in the differential diagnosis were ruled out. We believe this is a very uncommon presentation of activity in lesions of morphea and should be made known to clinicians so that activity and progression of the disease can be recognized and treated to avoid complications.
authors.affiliation: University of Toronto.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: García-Romero
authors.forename: Glenn
authors.initials: G
authors.lastname: Taylor
authors.forename: Ronald
authors.initials: R
authors.lastname: Laxer
authors.forename: Elena
authors.initials: E
authors.lastname: Pope
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D017496:Hypopigmentation / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D014803:Vitamin B Complex; D005492:Folic Acid; D009173:Mycophenolic Acid; D008775:Methylprednisolone; D008727:Methotrexate