title: Analgesic efficacy of lysine clonixinate plus tramadol versus tramadol in multiple doses following impacted third molar surgery.
abstract: This study compared the analgesic and anti-inflammatory efficacy, trismus control, and tolerability of the combination of lysine clonixinate and tramadol (LCT) versus tramadol (T) alone after surgical removal of impacted mandibular third molars. This study was a double-blind, randomized clinical trial, including two study groups of 20 patients each, who exhibited acute pain subsequent to surgical extraction of two mandibular third molars. Pain intensity was quantified over a 96-h period using a visual analogue scale and a 5-point verbal rating scale. Secondary indicators of analgesic and anti-inflammatory efficacy, trismus control, and tolerability were determined. Patients administered LCT exhibited better therapeutic effects that those administered T. Fifty percent of patients in the LCT group rated this therapy as 'excellent analgesia' compared with only 10% in the T group. The onset of the analgesic effect of LCT was significantly faster, without any therapeutic failures. There were no significant differences between the groups with regard to anti-inflammatory effect or trismus. The results of this study suggest that the postsurgical analgesic efficacy of LCT in combination (LC 125 mg + T 25 mg) is superior to that obtained with T alone, administered at the standard dose of 50 mg, for up to 96 h after the extraction of both impacted mandibular third molars.
authors.affiliation: Department of Pharmacology, Faculty of Chemistry, Universidad Autónoma de San Luis Potosí, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Perez-Urizar
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Rider
authors.affiliation: Dixpertia Investigación Biofarmacéutica y Farmacológica SC, San Luis Potosí, Mexico.
authors.forename: I
authors.initials: I
authors.lastname: Torres-Roque
authors.affiliation: Institutional Program in Engineering and Materials Sciences, Universidad Autónoma de San Luis Potosí, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Garrocho-Rangel
authors.affiliation: Basic Sciences Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, Mexico. Electronic address: apozos@uaslp.mx.
authors.forename: A
authors.initials: A
authors.lastname: Pozos-Guillen
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014095:Tooth, Impacted / Q000601:surgery*; D014147:Tramadol / Q000627:therapeutic use*; D016896:Treatment Outcome; D014313:Trismus / Q000517:prevention & control
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; C089163:lysine clonixinate; D014147:Tramadol; D008239:Lysine; D003002:Clonixin
keywords: Balanced analgesia; Lysine clonixinate; Third molar surgery; Tramadol