title: Spontaneously arising concurrent ileocaecal adenocarcinoma and renal pelvis transitional cell carcinoma in a rhesus macaque (Macaca mulatta).
abstract: A 25-year-old, female rhesus macaque (Macaca mulatta) presented with a history of weight loss despite a normal appetite and supportive care. The animal was humanely destroyed due to poor prognosis. Post-mortem examination revealed a focally extensive, firm, white annular constriction at the ileocaecal junction and an incidental finding of a pale white nodule approximately 0.8 cm in diameter in the left renal pelvis. Based on the microscopical findings, ileocaecal adenocarcinoma and renal pelvis transitional cell carcinoma (TCC) were diagnosed. The use of cytokeratin (CK)-7 and -20 and uroplakin III as potential renal TCC markers was evaluated. The neoplastic cells were labelled intensely with antibodies to uroplakin III, but not to CK-7 or -20. Spontaneous intestinal adenocarcinoma has been documented in the rhesus macaque, but concurrent renal pelvis TCC is highly unusual.
authors.affiliation: Division of Pathology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA. Electronic address: sgumber@emory.edu.
authors.forename: S
authors.initials: S
authors.lastname: Gumber
authors.forename: J S
authors.initials: JS
authors.lastname: Wood
authors.forename: A C
authors.initials: AC
authors.lastname: Jones
authors.forename: E
authors.initials: E
authors.lastname: Strobert
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007078:Ileal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007080:Ileocecal Valve / Q000473:pathology; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007682:Kidney Pelvis / Q000473:pathology; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: carcinoma; intestinal; renal; rhesus macaque
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