title: Corneal confocal microscopy anomalies associated with cowden syndrome: a case report.
abstract: OBJECTIVE
  To describe bilateral corneal alterations through confocal microscopy in a patient affected by Cowden syndrome (CS).
  
  
  METHODS
  Evaluation of Schirmer's, fluorescein, and lissamine green dye tests. Confocal microscopy was performed in both eyes to investigate corneal abnormalities.
  
  
  RESULTS
  Slit lamp observation showed the focal involvement of anterior stromal and epithelial layers. Schirmer's, fluorescein, and lissamine green dye test results were regular, while corneal confocal examination confirmed the disorganization of anterior stromal and epithelial layers in both eyes.
  
  
  CONCLUSIONS
  CS is a rare autosomal-dominant systemic disorder. In our case, confocal analysis revealed predominance of alterations in the anterior stromal corneal layer, showing an increase of reflectivity, and a totally unstructured architecture in the epithelium layer. Even though the main purpose remains the prevention and the early diagnosis of different systemic tumors that could occur in affected patients, corneal confocal evaluation could play an important role in the early diagnosis of this rare disease.
authors.affiliation: Eye Department, Second University of Naples (S.U.N.), Naples, Frosinone, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Sbordone
authors.forename: Alfonso
authors.initials: A
authors.lastname: Savastano
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Savastano
authors.forename: Vito
authors.initials: V
authors.lastname: Romano
authors.forename: Mario
authors.initials: M
authors.lastname: Bifani
authors.forename: Silvio
authors.initials: S
authors.lastname: Savastano
keywords: Corneal alterations; Corneal confocal microscopy; Cowden syndrome; Multiple hamartoma syndrome
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