title: Breast ductal carcinoma in situ: morphologic and kinetic MRI findings.
abstract: BACKGROUND
  Adequate diagnosis of ductal carcinoma in situ (DCIS) could lead to efficacious treatment. Due to the fact that DCIS lesions can progress to invasive carcinomas and that the sensitivity of the standard examination - mammography - is between 70 and 80%, use of a more sensitive diagnostic tool was needed. In detection of DCIS, contrast-enhanced magnetic resonance imaging (CE-MRI) has the sensitivity up to 96%.
  
  
  OBJECTIVE
  Morphological features and kinetic parameters were evaluated to define the most regular morphological, kinetic and morpho-kinetic patterns on MRI assessment of breast ductal carcinoma in situ (DCIS).
  
  
  METHODS
  We retrospectively assessed eighteen patients with 23 histologically confirmed lesions (mean age, 52.4 ± 10.5 years). All patients were clinically and mammographically examined prior to MRI examination.
  
  
  RESULTS
  DCIS appeared most frequently as non-mass-like lesions (12 lesions, 52.17%). The differences in the frequency of lesion types were statistically significant (P<0.05). The following morphological patterns were detected: A: no specific morphologic features, B: linear/branching enhancement, C: focal mass-like enhancement, D: segmental enhancement, E: segmental enhancement in triangular shape, F: diffuse enhancement, G: regional heterogeneous enhancement in one quadrant not conforming to duct distribution and H: dotted or granular type of enhancement with patchy distribution. The difference in the frequency of the proposed patterns was statistically significant (P<0.05). There were eight lesions with mass enhancement, and six with segmental lesions: regional and triangular. There was no statistically significant difference in the frequency of enhancement curve types (P>0.05). There was no significant difference in the frequency of morpho-kinetic patterns.
  
  
  CONCLUSIONS
  Non-mass-like lesions, lesions with focal or segmental distribution, with a "plateau" enhancement curve type were the most frequent findings of DCIS lesions on MRI.
authors.affiliation: Department of Diagnostic Imaging, Institute of Oncology and Radiology of Serbia (IORS), Belgrade, Serbia.
authors.forename: Mirjan M
authors.initials: MM
authors.lastname: Nadrljanski
authors.forename: Biljana B
authors.initials: BB
authors.lastname: Marković
authors.forename: Zorica Č
authors.initials: ZČ
authors.lastname: Milošević
keywords: Breast Neoplasms; Carcinoma, Intraductal, Non infiltrating; Gadolinium DTPA; Image Enhancement; Magnetic Resonance Imaging
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