title: Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailability in vivo.
abstract: Long-circulating nanoliposomes (LCNs) containing Baicalein (BAI) were prepared by diethyl ether injection method in this paper. Using soybean phosphatidylcholine (SPC) and cholesterol (CHOL) as the carrier ingredients, BAI-loaded LCNs were formulated in optimized condition with encapsulation efficiency (EE) of 41.5±4.77%. The average diameter of BAI-loaded LCNs was ∼709 nm determined by dynamic light scattering (PDI 0.43). Drug storage stability study showed that BAI-loaded LCNs were highly stable in phosphate-buffered saline (PBS, pH 7.4) at 4 °C. Additionally, the pharmacokinetic behaviors of BAI-loaded LCNs were studied using Kunming mice as experimental animals. Parallelly, free BAI solution was studied as control. As expected, it is found that LCNs-encapsulated BAI yields greater BAI oral bioavailability with 4.52 times of free BAI. These results suggest the potential applications of LCNs for the delivery of BAI.
authors.affiliation: Chemical Engineering and Pharmaceutics School and.
authors.forename: Ju
authors.initials: J
authors.lastname: Liang
authors.forename: Wenlan
authors.initials: W
authors.lastname: Wu
authors.forename: Qiuwei
authors.initials: Q
authors.lastname: Liu
authors.forename: Shan
authors.initials: S
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002784:Cholesterol / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D004356:Drug Storage; D044950:Flavanones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008027:Light; D008081:Liposomes; D008297:Male; D051379:Mice; D053758:Nanoparticles; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D012542:Scattering, Radiation; D013025:Glycine max / Q000737:chemistry
chemical_list: D000975:Antioxidants; D044950:Flavanones; D008081:Liposomes; D010713:Phosphatidylcholines; C006680:baicalein; D002784:Cholesterol