title: Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies.
abstract: OBJECTIVE
  Whether selective amygdalohippocampectomy (SelAH) has similar seizure outcomes and better neuropsychological outcomes compared with anterior temporal lobectomy (ATL) is a matter of debate. The aim of this study was to compare the 2 types of surgery with respect to seizure outcomes and changes in IQ scores.
  
  
  METHODS
  PubMed, Embase, and the Cochrane Library were searched for relevant studies published between January 1990 and September 2012. Studies comparing SelAH and ATL with respect to seizure and intelligence outcomes were included. Two reviewers assessed the quality of the included studies and independently extracted the data. Odds ratios and standardized mean deviations with 95% confidence intervals were used to compare pooled proportions of freedom from seizures and changes in IQ scores between the SelAH and ATL groups.
  
  
  RESULTS
  Three prospective and 10 retrospective studies were identified involving 745 and 766 patients who underwent SelAH and ATL, respectively. The meta-analysis demonstrated a statistically significant reduction in the odds of seizure freedom for patients who underwent SelAH compared with those who underwent ATL (OR 0.65 [95% CI 0.51-0.82], p = 0.0005). The differences between the changes in all IQ scores after the 2 types of surgery were not statistically significant, regardless of the side of resection.
  
  
  CONCLUSIONS
  Selective amygdalohippocampectomy statistically reduced the odds of being seizure free compared with ATL, but the clinical significance of this reduction needs to be further validated by well-designed randomized trials. Selective amygdalohippocampectomy did not have better outcomes than ATL with respect to intelligence.
authors.affiliation: Beijing Neurosurgical Institute and.
authors.forename: Wen-Han
authors.initials: WH
authors.lastname: Hu
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Fan-Gang
authors.initials: FG
authors.lastname: Meng
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
mesh_terms: D000679:Amygdala / Q000601:surgery*; D038481:Anterior Temporal Lobectomy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D006624:Hippocampus / Q000601:surgery*; D006801:Humans; D013702:Temporal Lobe / Q000601:surgery*