title: The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis.
abstract: The re-emergence of tuberculosis in recent years led the World Health Organization (WHO) to launch the Stop TB Strategy program. Beside repurposing the existing drugs and exploring novel molecular combinations, an essential step to face the burden of tuberculosis will be to develop new drugs by identifying vulnerable bacterial targets. Recent studies have focused on decaprenylphosphoryl-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis, an essential enzyme involved in cell wall metabolism, for which new promising molecules have proved efficacy as antitubercular agents. This review summarizes the state of the art concerning DprE1 in terms of structure, enzymatic activity and inhibitors. This enzyme is emerging as one of the most vulnerable target in M. tuberculosis.
authors.affiliation: Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, via Ferrata 1, 27100, Pavia, Italy, giovanna.riccardi@unipv.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Riccardi
authors.forename: Maria Rosalia
authors.initials: MR
authors.lastname: Pasca
authors.forename: Laurent Roberto
authors.initials: LR
authors.lastname: Chiarelli
authors.forename: Giulia
authors.initials: G
authors.lastname: Manina
authors.forename: Andrea
authors.initials: A
authors.lastname: Mattevi
authors.forename: Claudia
authors.initials: C
authors.lastname: Binda
mesh_terms: D000429:Alcohol Oxidoreductases; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; C583625:DprE1 protein, Mycobacterium tuberculosis