title: Synthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands.
abstract: A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.
authors.affiliation: Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-CityU, Suzhou, Jiangsu 215123 and and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Tang
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Ni
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Leung
authors.forename: Wai-Lun
authors.initials: WL
authors.lastname: Man
authors.forename: Kenneth King-Kwan
authors.initials: KK
authors.lastname: Lau
authors.forename: Yimin
authors.initials: Y
authors.lastname: Liang
authors.forename: Yun-Wah
authors.initials: YW
authors.lastname: Lam
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.forename: Shie-Ming
authors.initials: SM
authors.lastname: Peng
authors.forename: Gui-Jian
authors.initials: GJ
authors.lastname: Liu
authors.forename: Tai-Chu
authors.initials: TC
authors.lastname: Lau
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005290:Ferric Compounds / Q000737:chemistry*; D005434:Flow Cytometry; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D009992:Osmium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005290:Ferric Compounds; D008024:Ligands; C540999:iron nitrido complex; D009992:Osmium