title: Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis.
abstract: Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.
authors.affiliation: 1. Department of Gastroenterology, Yamagata University School of Medicine, Yamagata, Yamagata 990-9585;
authors.forename: Tetsuru
authors.initials: T
authors.lastname: Karasawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Soga
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010427:Pentose Phosphate Pathway / Q000187:drug effects; D012254:Ribavirin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin
keywords: HCV; anemia; glycolysis; metabolome; pentose phosphate cycle.; ribavirin
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