title: Involvement of androgens in ovarian health and disease.
abstract: In women, ovary and adrenal gland produce androgens. Androgens are essential drivers of the primordial to antral follicle development, prior to serving as substrate for estrogen production in the later stages of folliculogenesis. Androgens play a crucial role in the follicular-stromal intertalk by fine tuning the extracellular matrix and vessel content of the ovarian stroma. Local auto-and paracrine factors regulate androgen synthesis in the pre-antral follicle. Androgen excess is a hallmark of polycystic ovary syndrome and is a key contributor in the exaggerated antral follicle formation, stromal hyperplasia and hypervascularity. Hyperandrogenaemia overrides the follicular-stromal dialog, resulting in follicular arrest and disturbed ovulation. On the other hand, androgen deficiency is likely to have a negative impact on fertility as well, and further research is needed to examine the benefits of androgen-replacement therapy in subfertility.
authors.affiliation: Centre for Endocrinology, Diabetes and Metabolism (CEDAM), School of Clinical & Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: M
authors.initials: M
authors.lastname: Lebbe
authors.forename: T K
authors.initials: TK
authors.lastname: Woodruff
mesh_terms: D000728:Androgens / Q000502:physiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000378:metabolism; D010049:Ovarian Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology; D006080:Ovarian Follicle / Q000254:growth & development* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000209:etiology* / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism
chemical_list: D000728:Androgens; D011944:Receptors, Androgen
keywords: androgen; angiogenesis; folliculogenesis; polycystic ovary syndrome; stroma
references.citation: J Clin Oncol. 2002 Jul 1;20(13):3001-15
references.pmid: 12089231
references.citation: Biol Reprod. 2002 Apr;66(4):906-16
references.pmid: 11906908
references.citation: Hum Reprod. 1998 Jun;13(6):1437-41
references.pmid: 9688367
references.citation: Steroids. 2011 Dec 20;76(14):1590-6
references.pmid: 22019845
references.citation: J Biol Chem. 2007 Oct 5;282(40):29584-93
references.pmid: 17635910
references.citation: Hum Reprod Update. 2011 Jan-Feb;17(1):17-33
references.pmid: 20639519
references.citation: Hum Reprod. 1994 Feb;9(2):188-91
references.pmid: 8027271
references.citation: Mol Cell Endocrinol. 2005 Jan 14;229(1-2):3-10
references.pmid: 15607523
references.citation: Hum Reprod. 2006 Sep;21(9):2223-7
references.pmid: 16720622
references.citation: Hum Reprod. 2012 Mar;27(3):637-40
references.pmid: 22252080
references.citation: J Clin Endocrinol Metab. 2008 Nov;93(11):4456-61
references.pmid: 18697861
references.citation: Hum Reprod. 1995 Aug;10(8):1992-6
references.pmid: 8567828
references.citation: Fertil Steril. 2011 Jun 30;95(8):e73-4; author reply e75
references.pmid: 21601849
references.citation: Fertil Steril. 2012 Mar;97(3):779-85
references.pmid: 22244782
references.citation: Endocrinol Metab Clin North Am. 1999 Jun;28(2):361-78
references.pmid: 10352923
references.citation: Clin Cancer Res. 2003 Jul;9(7):2416-25
references.pmid: 12855613
references.citation: Mol Hum Reprod. 2000 May;6(5):443-7
references.pmid: 10775648
references.citation: Hum Reprod. 2010 Oct;25(10):2496-500
references.pmid: 20729538
references.citation: Baillieres Clin Obstet Gynaecol. 1997 Jun;11(2):249-60
references.pmid: 9536210
references.citation: J Clin Endocrinol Metab. 1999 Aug;84(8):2951-6
references.pmid: 10443703
references.citation: Endocrinology. 2000 Oct;141(10):3814-20
references.pmid: 11014238
references.citation: Fertil Steril. 2013 Jul;100(1):2-11
references.pmid: 23809624
references.citation: J Clin Endocrinol Metab. 1998 Jul;83(7):2479-85
references.pmid: 9661631
references.citation: Hum Reprod. 2010 May;25(5):1282-7
references.pmid: 20228388
references.citation: Hum Reprod. 2009 Nov;24(11):2917-23
references.pmid: 19617605
references.citation: Mol Endocrinol. 2010 Jul;24(7):1393-403
references.pmid: 20501640
references.citation: J Reprod Fertil. 1975 Dec;45(3):559-66
references.pmid: 128630
references.citation: Hum Reprod Update. 2003 Nov-Dec;9(6):505-14
references.pmid: 14714587
references.citation: Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1210-21
references.pmid: 21257919
references.citation: Endocrinology. 2001 Nov;142(11):4891-9
references.pmid: 11606457
references.citation: J Biol Chem. 2004 Apr 9;279(15):14579-86
references.pmid: 14668339
references.citation: J Bone Miner Res. 2004 Jul;19(7):1181-90
references.pmid: 15177002
references.citation: Mol Hum Reprod. 2009 Dec;15(12):795-803
references.pmid: 19710243
references.citation: J Reprod Fertil. 1998 May;113(1):27-33
references.pmid: 9713373
references.citation: Endocrinology. 2009 Jun;150(6):2740-8
references.pmid: 19213837
references.citation: Lancet. 2003 Sep 27;362(9389):1017-21
references.pmid: 14522531
references.citation: J Assist Reprod Genet. 2011 Jan;28(1):3-6
references.pmid: 20872066
references.citation: Steroids. 2000 Oct-Nov;65(10-11):599-603
references.pmid: 11108865
references.citation: Biol Reprod. 2006 Dec;75(6):924-32
references.pmid: 16943368
references.citation: J Clin Endocrinol Metab. 2011 Jun;96(6):1754-62
references.pmid: 21430025
references.citation: Science. 2003 Jul 11;301(5630):215-8
references.pmid: 12855809
references.citation: Hum Reprod. 1992 Feb;7(2):184-90
references.pmid: 1577930
references.citation: Clin Endocrinol (Oxf). 2013 Apr;78(4):497-502
references.pmid: 23153216
references.citation: Hum Reprod Update. 2008 Jul-Aug;14(4):367-78
references.pmid: 18499708
references.citation: Prog Brain Res. 2010;182:97-148
references.pmid: 20541662
references.citation: Reproduction. 2002 Nov;124(5):601-9
references.pmid: 12416998
references.citation: J Clin Endocrinol Metab. 2010 Sep;95(9):4354-60
references.pmid: 20610594
references.citation: Mol Hum Reprod. 2004 Feb;10(2):77-83
references.pmid: 14742691
references.citation: Endocr Rev. 1995 Jun;16(3):322-53
references.pmid: 7671850
references.citation: Reprod Biol Endocrinol. 2010 Nov 10;8:140
references.pmid: 21067609
references.citation: Mol Cell Endocrinol. 2012 Aug 15;359(1-2):53-65
references.pmid: 21664422
references.citation: BMC Cardiovasc Disord. 2007 May 08;7:13
references.pmid: 17488510
references.citation: Reproduction. 2010 Oct;140(4):489-504
references.pmid: 20628033
references.citation: J Clin Invest. 1993 May;91(5):2235-43
references.pmid: 7683699
references.citation: Am J Physiol Endocrinol Metab. 2008 May;294(5):E961-8
references.pmid: 18349113
references.citation: Fertil Steril. 1993 Feb;59(2):323-31
references.pmid: 8425626
references.citation: Endocrinology. 2007 Aug;148(8):3781-91
references.pmid: 17495003
references.citation: Obstet Gynecol Surv. 1982 Feb;37(2):59-77
references.pmid: 7033852
references.citation: Reproduction. 2011 Jun;141(6):809-20
references.pmid: 21389078
references.citation: J Clin Endocrinol Metab. 2007 Mar;92(3):1034-40
references.pmid: 17179193
references.citation: Fertil Steril. 2010 Dec;94(7):2938-41
references.pmid: 20684953
references.citation: Hum Reprod. 2009 May;24(5):1142-51
references.pmid: 19189992
references.citation: Endocrinology. 2008 Mar;149(3):889-98
references.pmid: 18079198
references.citation: Endocr Rev. 2012 Dec;33(6):981-1030
references.pmid: 23065822
references.citation: J Clin Endocrinol Metab. 2006 Oct;91(10):3697-710
references.pmid: 17018650
references.citation: Fertil Steril. 2008 May;89(5 Suppl):1364-70
references.pmid: 17517397
references.citation: Endocrinology. 1998 Nov;139(11):4672-8
references.pmid: 9794479
references.citation: Endocrinology. 2001 Nov;142(11):4930-6
references.pmid: 11606461
references.citation: Hum Reprod. 2006 Nov;21(11):2845-9
references.pmid: 16997936
references.citation: Biol Reprod. 2011 Jan;84(1):87-96
references.pmid: 20739662
references.citation: Reprod Biol Endocrinol. 2009 Oct 07;7:108
references.pmid: 19811650
references.citation: Fertil Steril. 2005 Sep;84(3):756
references.pmid: 16169414
references.citation: Endocr Rev. 2004 Aug;25(4):581-611
references.pmid: 15294883
references.citation: Reprod Biomed Online. 2010 Sep;21(3):360-5
references.pmid: 20638339
references.citation: Hum Reprod. 2005 Jul;20(7):1814-9
references.pmid: 15802320
references.citation: J Clin Endocrinol Metab. 1998 Jun;83(6):2001-5
references.pmid: 9626131
references.citation: Expert Rev Endocrinol Metab. 2012 Sep;7(5):515-529
references.pmid: 30780897
references.citation: Science. 2008 Feb 1;319(5863):611-3
references.pmid: 18239123
references.citation: Hum Reprod. 2009 Nov;24(11):2760-6
references.pmid: 19640893
references.citation: Nat Rev Endocrinol. 2012 Jan 10;8(6):331-41
references.pmid: 22231848
references.citation: Hum Reprod. 2013 Feb;28(2):453-61
references.pmid: 23188113
references.citation: Reproduction. 2006 Jan;131(1):1-9
references.pmid: 16388003
references.citation: Biochim Biophys Acta. 2012 Dec;1822(12):1896-912
references.pmid: 22634430
references.citation: Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1426-35
references.pmid: 23530236
references.citation: Hum Reprod. 2005 Jul;20(7):1820-6
references.pmid: 15802325
references.citation: Hum Reprod. 2009 Sep;24(9):2264-75
references.pmid: 19520713
references.citation: Mol Endocrinol. 2002 Oct;16(10):2181-7
references.pmid: 12351684
references.citation: Fertil Steril. 2010 May 1;93(7):2337-47
references.pmid: 19409555
references.citation: J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53
references.pmid: 15827095
references.citation: Am J Pathol. 2013 Jun;182(6):1942-9
references.pmid: 23570837
references.citation: Aging Cell. 2012 Dec;11(6):1121-4
references.pmid: 22823533
references.citation: Reprod Biol Endocrinol. 2011 May 17;9:67
references.pmid: 21586137
references.citation: Ann N Y Acad Sci. 2006 Dec;1092:175-86
references.pmid: 17308143
references.citation: Int J Gynaecol Obstet. 2011 Feb;112(2):119-21
references.pmid: 21144516
references.citation: Ann Saudi Med. 2010 Nov-Dec;30(6):442-7
references.pmid: 20940513
references.citation: Microsurgery. 2012 Sep;32(6):475-81
references.pmid: 22707412
references.citation: Cell. 2001 Mar 9;104(5):719-30
references.pmid: 11257226
references.citation: Gynecol Endocrinol. 2006 Aug;22(8):465-70
references.pmid: 17012110
references.citation: J Steroid Biochem Mol Biol. 2011 Jan;123(1-2):58-64
references.pmid: 21056661
references.citation: Nature. 1996 Oct 10;383(6600):531-5
references.pmid: 8849725
references.citation: Ann Endocrinol (Paris). 2010 May;71(3):228-30
references.pmid: 20362969
references.citation: Hum Pathol. 1994 Nov;25(11):1198-204
references.pmid: 7959665
references.citation: Eur J Endocrinol. 2006 Jan;154(1):1-11
references.pmid: 16381985
references.citation: Hum Reprod. 2000 Oct;15(10):2129-32
references.pmid: 11006185
references.citation: Mol Endocrinol. 2004 Dec;18(12):3050-63
references.pmid: 15308691
references.citation: Hum Reprod. 2002 May;17(5):1399-403
references.pmid: 11980771
references.citation: Reprod Biol Endocrinol. 2011 Feb 07;9:23
references.pmid: 21299886
references.citation: Endocrinology. 2012 Jun;153(6):2861-9
references.pmid: 22334715
references.citation: Fertil Steril. 2010 Aug;94(3):1118-21
references.pmid: 20060112
references.citation: J Clin Invest. 1998 Jun 15;101(12):2622-9
references.pmid: 9637695
references.citation: Clin Exp Reprod Med. 2012 Mar;39(1):10-4
references.pmid: 22563545
references.citation: Domest Anim Endocrinol. 2013 May;44(4):185-94
references.pmid: 23571006
references.citation: Mol Hum Reprod. 2011 Jan;17(1):63-70
references.pmid: 20843821
references.citation: J Clin Endocrinol Metab. 2006 Mar;91(3):941-5
references.pmid: 16368745
references.citation: Endocrinology. 2010 Feb;151(2):774-82
references.pmid: 20032061
references.citation: Cell Cycle. 2004 Mar;3(3):372-9
references.pmid: 14726697
references.citation: Development. 2007 Jan;134(1):199-209
references.pmid: 17164425
references.citation: Hum Reprod. 2007 Sep;22(9):2501-8
references.pmid: 17635847
references.citation: Biophys J. 2004 Aug;87(2):768-79
references.pmid: 15298886
references.citation: Biol Reprod. 2009 Apr;80(4):685-95
references.pmid: 19074005
references.citation: Biochem Biophys Res Commun. 2012 Feb 10;418(2):319-23
references.pmid: 22266320
references.citation: Lancet. 1991 Jun 8;337(8754):1375-7
references.pmid: 1674764
references.citation: Dev Biol. 2008 Sep 1;321(1):197-204
references.pmid: 18601916
references.citation: Fertil Steril. 2012 Jan;97(1):28-38.e25
references.pmid: 22153789
references.citation: Fertil Steril. 2013 Jul;100(1):23-38
references.pmid: 23472949
references.citation: Endocr Rev. 2002 Apr;23(2):175-200
references.pmid: 11943742
references.citation: Mol Hum Reprod. 2007 Aug;13(8):527-35
references.pmid: 17557764
references.citation: Biol Reprod. 1999 Aug;61(2):353-7
references.pmid: 10411511
references.citation: Trends Endocrinol Metab. 2010 Feb;21(2):96-103
references.pmid: 19913438
references.citation: Hum Reprod. 2003 Jul;18(7):1432-7
references.pmid: 12832368
references.citation: Endocrinology. 2005 Apr;146(4):1883-92
references.pmid: 15625241
references.citation: Hum Reprod. 1999 Sep;14(9):2328-32
references.pmid: 10469704
references.citation: J Ovarian Res. 2010 Jul 21;3:16
references.pmid: 20663178
references.citation: Hum Mol Genet. 2009 Aug 1;18(15):2813-24
references.pmid: 19423553
references.citation: Hum Reprod. 1998 Mar;13(3):651-5
references.pmid: 9572428
references.citation: J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33
references.pmid: 11739466
references.citation: Biol Reprod. 2000 Feb;62(2):370-7
references.pmid: 10642575
references.citation: Biol Reprod. 2006 Dec;75(6):916-23
references.pmid: 16957022