title: Malfolded protein structure and proteostasis in lung diseases.
abstract: Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.
authors.affiliation: 1 Department of Cell Biology and Chemical Physiology, The Scripps Research Institute, La Jolla, California.
authors.forename: William E
authors.initials: WE
authors.lastname: Balch
authors.forename: Jacob I
authors.initials: JI
authors.lastname: Sznajder
authors.forename: Scott
authors.initials: S
authors.lastname: Budinger
authors.forename: Daniel
authors.initials: D
authors.lastname: Finley
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Laposky
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Cuervo
authors.forename: Ivor J
authors.initials: IJ
authors.lastname: Benjamin
authors.forename: Esther
authors.initials: E
authors.lastname: Barreiro
authors.forename: Richard I
authors.initials: RI
authors.lastname: Morimoto
authors.forename: Lisa
authors.initials: L
authors.lastname: Postow
authors.forename: Allan M
authors.initials: AM
authors.lastname: Weissman
authors.forename: Dorothy
authors.initials: D
authors.lastname: Gail
authors.forename: Susan
authors.initials: S
authors.lastname: Banks-Schlegel
authors.forename: Thomas
authors.initials: T
authors.lastname: Croxton
authors.forename: Weiniu
authors.initials: W
authors.lastname: Gan
mesh_terms: D000375:Aging; D035843:Biomedical Research; D055808:Drug Discovery; D004493:Education; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D054555:National Heart, Lung, and Blood Institute (U.S.); D017510:Protein Folding / Q000187:drug effects; D057165:Proteostasis Deficiencies / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy; D014481:United States
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