title: 5-lipoxygenase mRNA and protein isoforms.
abstract: 5-Lipoxygenase (5-LO) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets.
authors.affiliation: Institute of Pharmaceutical Chemistry/ZAFES, Goethe University Frankfurt, Frankfurt/M, Germany; Department of Biology, Technical University Darmstadt, Darmstadt, Germany.
authors.forename: Meike J
authors.initials: MJ
authors.lastname: Ochs
authors.forename: Beatrix
authors.initials: B
authors.lastname: Suess
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhilber
mesh_terms: D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics* / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D015289:Leukotrienes; D020033:Protein Isoforms; D020543:Proteome; D012333:RNA, Messenger; D001094:Arachidonate 5-Lipoxygenase