title: Gastrointestinal tone; its genesis and contribution to the physical processes of digestion.
abstract: BACKGROUND
  Myogenic tone has long been recognised as an important component of gastrointestinal motility. Recent work has clarified the cellular mechanisms that engender tone and the neurogenic and mechanical stimuli that modulate it but has also highlighted cellular and regional specialisation in these mechanisms within the GI tract. Smooth muscle in all segments of the gut has the capability of latching, i.e. can generate ongoing specific rather than tetanic tone. This is likely modulated by both direct and indirect input from agonists such as acetylcholine and mechanoreceptors, the latter originating in ICC-IM, smooth muscle cells or elements of the ENS. Tonic contraction can occur in the absence of phasic contractions or concurrent with them, and it can modulate wall compliance and the capacity of particular segments, thereby affecting the level of on-flow and mixing, both luminal and adjacent to the mucosa.
  
  
  OBJECTIVE
  The review seeks to provide an overview of our understanding of the mechanism by which tone is generated and maintained, highlighting its modulation by neurogenic and mechanical stimuli, its mechanical consequences in the walls of the various segments of the gastrointestinal tract and its contribution to flow and mixing of contained digesta.
authors.affiliation: Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.
authors.forename: R G
authors.initials: RG
authors.lastname: Lentle
authors.forename: G W
authors.initials: GW
authors.lastname: Reynolds
authors.forename: P W M
authors.initials: PW
authors.lastname: Janssen
mesh_terms: D004063:Digestion / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D009124:Muscle Proteins / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology
chemical_list: D009124:Muscle Proteins
keywords: genesis; physical processes; tone