title: Effects of a diet enriched with polyunsaturated, saturated, or trans fatty acids on cytokine content in the liver, white adipose tissue, and skeletal muscle of adult mice.
abstract: This study analyzed the effect of diet enriched with 30% lipids on cytokines content in different tissues. Swiss male mice were distributed into four groups treated for 8 weeks with control (C, normolipidic diet); soybean oil (S); lard (L); and hydrogenated vegetable fat (H). We observed an increase in carcass fat in groups S and L, and the total amount of fatty deposits was only higher in group L compared with C group. The serum levels of free fatty acids were lower in the L group, and insulin, adiponectin, lipid profile, and glucose levels were similar among the groups. IL-10 was lower in group L in mesenteric and retroperitoneal adipose tissues. H reduced IL-10 only in retroperitoneal adipose tissue. There was an increase in IL-6 in the gastrocnemius muscle of the L group, and a positive correlation between TNF-α and IL-10 was observed in the livers of groups C, L, and H and in the muscles of all groups studied. The results suggested relationships between the quantity and quality of lipids ingested with adiposity, the concentration of free fatty acids, and cytokine production in white adipose tissue, gastrocnemius muscle, and liver.
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina, 04020-050 São Paulo, SP, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: dos Santos
authors.forename: Debora
authors.initials: D
authors.lastname: Estadella
authors.forename: Ana Cláudia Losinskas
authors.initials: AC
authors.lastname: Hachul
authors.forename: Marcos Hiromu
authors.initials: MH
authors.lastname: Okuda
authors.forename: Mayara Franzoi
authors.initials: MF
authors.lastname: Moreno
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.forename: Eliane Beraldi
authors.initials: EB
authors.lastname: Ribeiro
authors.forename: Claudia Maria da Penha
authors.initials: CM
authors.lastname: Oller do Nascimento
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D016207:Cytokines / Q000378:metabolism*; D004032:Diet; D004797:Enzyme-Linked Immunosorbent Assay; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D007328:Insulin / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism*; D044242:Trans Fatty Acids / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D005231:Fatty Acids, Unsaturated; C556062:IL10 protein, mouse; D007328:Insulin; D015850:Interleukin-6; D044242:Trans Fatty Acids; D014409:Tumor Necrosis Factor-alpha; C577686:interleukin-6, mouse; D016753:Interleukin-10
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