title: Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models.
abstract: BACKGROUND
  Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats.
  
  
  METHODS
  Animals were subjected to GB, DS or laparotomy (controls), and monitored by an open-circuit indirect calorimeter composed of comprehensive laboratory animal monitoring system and adiabatic bomb calorimeter.
  
  
  RESULTS
  Body weight loss was greater after DS than GB. Food intake was reduced after DS but not GB. Energy expenditure was increased after either GB or DS. Fecal energy content was increased after DS but not GB.
  
  
  CONCLUSIONS
  GB induced body weight loss by increasing energy expenditure, whereas DS induced greater body weight loss by reducing food intake, increasing energy expenditure and causing malabsorption in rat models.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kodama
authors.forename: Helene
authors.initials: H
authors.lastname: Johannessen
authors.forename: Marianne W
authors.initials: MW
authors.lastname: Furnes
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Zhao
authors.forename: Gjermund
authors.initials: G
authors.lastname: Johnsen
authors.forename: Ronald
authors.initials: R
authors.lastname: Mårvik
authors.forename: Bård
authors.initials: B
authors.lastname: Kulseng
authors.forename: Duan
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D050110:Bariatric Surgery; D001835:Body Weight; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D004386:Duodenum / Q000601:surgery*; D004734:Energy Metabolism; D005247:Feeding Behavior; D005743:Gastrectomy; D015390:Gastric Bypass / Q000401:mortality; D007813:Laparotomy; D008297:Male; D011183:Postoperative Complications / Q000401:mortality; D051381:Rats
chemical_list: D016207:Cytokines
references.citation: J Gastrointest Surg. 2010 Oct;14(10):1502-10
references.pmid: 20824380
references.citation: Res Nurs Health. 1998 Dec;21(6):557-62
references.pmid: 9839800
references.citation: Br J Surg. 2010 Feb;97(2):160-6
references.pmid: 20035530
references.citation: Obes Surg. 2012 May;22(5):697-703
references.pmid: 22411569
references.citation: Gastroenterology. 2010 May;138(5):1845-53
references.pmid: 19931268
references.citation: Diabetes. 2010 Feb;59(2):323-9
references.pmid: 20103710
references.citation: Surg Obes Relat Dis. 2013 Jul-Aug;9(4):526-30
references.pmid: 22498360
references.citation: Surg Obes Relat Dis. 2007 Jan-Feb;3(1):31-6
references.pmid: 17116424
references.citation: Obes Rev. 2010 Dec;11(12):907-20
references.pmid: 20051020
references.citation: Ann Surg. 2006 Oct;244(4):611-9
references.pmid: 16998370
references.citation: Nat Methods. 2011 Dec 28;9(1):57-63
references.pmid: 22205519
references.citation: J Int Med Res. 2002 Jul-Aug;30(4):442-4
references.pmid: 12235929
references.citation: Gastrointest Endosc. 2009 Nov;70(5):985-90
references.pmid: 19879406
references.citation: Obes Surg. 2012 Dec;22(12):1827-34
references.pmid: 23011462
references.citation: Obes Res. 2004 Aug;12(8):1197-211
references.pmid: 15340100
references.citation: Obes Surg. 2008 Apr;18(4):415-22
references.pmid: 18247101
references.citation: Int J Obes (Lond). 2012 Mar;36(3):348-55
references.pmid: 22124454
references.citation: Food Chem Toxicol. 2001 Mar;39(3):209-28
references.pmid: 11278053
references.citation: Endocrinology. 2012 May;153(5):2234-44
references.pmid: 22416083
references.citation: J Nutr. 1999 Aug;129(8):1593-6
references.pmid: 10419996
references.citation: Public Health Nutr. 2005 Oct;8(7A):1028-36
references.pmid: 16277818
references.citation: Ann Intern Med. 2011 Sep 6;155(5):281-91
references.pmid: 21893621
references.citation: Am J Clin Nutr. 1999 Jun;69(6):1064-5
references.pmid: 10357722
references.citation: J Abnorm Psychol. 2001 Feb;110(1):40-8
references.pmid: 11261398
references.citation: Ann Surg. 1987 Oct;206(4):414-26
references.pmid: 3662657
references.citation: Obes Surg. 2009 Oct;19(10):1430-8
references.pmid: 19506986
references.citation: Sci Transl Med. 2013 Mar 27;5(178):178ra41
references.pmid: 23536013
references.citation: Obes Surg. 2011 Oct;21(10):1617-28
references.pmid: 21359589
references.citation: Physiol Behav. 2012 Nov 5;107(4):476-83
references.pmid: 22366157
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2011 Jan;158(1):17-21
references.pmid: 20858551
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1450-67
references.pmid: 15637168
references.citation: J Epidemiol. 2006 May;16(3):117-24
references.pmid: 16710080
references.citation: Ann Surg. 2003 Oct;238(4):618-27; discussion 627-8
references.pmid: 14530733
references.citation: Minerva Chir. 2012 Apr;67(2):153-63
references.pmid: 22487917
references.citation: Surg Obes Relat Dis. 2011 Nov-Dec;7(6):703-8
references.pmid: 22014481
references.citation: Obes Surg. 2013 Jan;23(1):39-49
references.pmid: 22949011
references.citation: Am J Clin Nutr. 1999 Jun;69(6):1117-22
references.pmid: 10357728
references.citation: Ann Surg. 2000 Apr;231(4):524-8
references.pmid: 10749613
references.citation: J Gastrointest Surg. 2010 Feb;14(2):211-20
references.pmid: 19937190
references.citation: J Gastrointest Surg. 2006 Dec;10(10):1384-91
references.pmid: 17175458
references.citation: Eur Surg Res. 2008;40(3):279-88
references.pmid: 18253047
references.citation: Br J Surg. 1983 Jul;70(7):393-7
references.pmid: 6347313
references.citation: Surg Obes Relat Dis. 2010 Jul-Aug;6(4):408-14
references.pmid: 20655023
references.citation: Obesity (Silver Spring). 2009 Oct;17(10):1839-47
references.pmid: 19556976
references.citation: Int J Obes (Lond). 2011 Sep;35 Suppl 3:S35-9
references.pmid: 21912386
references.citation: BMJ. 2009 Sep 22;339:b3402
references.pmid: 19773325