title: Activation of the hTAS2R14 human bitter-taste receptor by (-)-epigallocatechin gallate and (-)-epicatechin gallate.
abstract: Tea catechins have strong bitterness and influence the taste of tea. Among the 25 human bitter-taste receptors (TAS2Rs), we found that hTAS2R14 responded to catechins, in addition to hTAS2R39, a known catechin receptor. Although hTAS2R14 responded to (-)-epicatechin gallate and (-)-epigallocatechin gallate, it did not respond to (-)-epicatechin and (-)-epigallocatechin.
authors.affiliation: Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka.
authors.forename: Toyomi
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Masataka
authors.initials: M
authors.lastname: Narukawa
authors.forename: Mineko
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Takumi
authors.initials: T
authors.lastname: Misaka
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D002118:Calcium / Q000378:metabolism; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D057809:HEK293 Cells; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D000098706:Taste Receptors, Type 2
chemical_list: D043562:Receptors, G-Protein-Coupled; D000098706:Taste Receptors, Type 2; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; D002118:Calcium