title: ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue.
abstract: We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7 μg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 μg) (P < 0.05). Resistin reduced uncoupling protein-1 mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain contributes to resistin's effects on thermogenesis.
authors.affiliation: School of Medical Sciences and Health Innovations Research Institute, RMIT University Melbourne, Australia.
authors.forename: Samin
authors.initials: S
authors.lastname: Kosari
authors.forename: Donny M
authors.initials: DM
authors.lastname: Camera
authors.forename: John A
authors.initials: JA
authors.lastname: Hawley
authors.forename: Martin
authors.initials: M
authors.lastname: Stebbing
authors.forename: Emilio
authors.initials: E
authors.lastname: Badoer
keywords: ERK1/2; Resistin; brown adipose tissue; thermogenesis
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