title: The mode of action of anticancer gold-based drugs: a structural perspective.
abstract: The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
authors.affiliation: Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
authors.forename: Federica
authors.initials: F
authors.lastname: Scaletti
authors.forename: Lara
authors.initials: L
authors.lastname: Massai
authors.forename: Maria A
authors.initials: MA
authors.lastname: Cinellu
authors.forename: Chiara
authors.initials: C
authors.lastname: Gabbiani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vergara
authors.forename: Antonello
authors.initials: A
authors.lastname: Merlino
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D001310:Auranofin / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D006046:Gold / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009113:Muramidase / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D001310:Auranofin; D006046:Gold; C421864:hen egg lysozyme; D009113:Muramidase