title: Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotides.
abstract: The invasion has begun: Invaders are shown to recognize DNA hairpins in cell-free assays and chromosomal DNA during non-denaturing fluorescence in situ hybridization (nd-FISH) experiments. As Invaders are devoid of inherent sequence limitations, many previously inaccessible DNA targets could become accessible to exogenous control with important ramifications for karyotyping, in vivo imaging, and gene regulation.
authors.affiliation: Minitube of America, Inc. PO Box 930187, 419 Venture Ct., Verona, WI 53593 (USA).
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Didion
authors.forename: Saswata
authors.initials: S
authors.lastname: Karmakar
authors.forename: Dale C
authors.initials: DC
authors.lastname: Guenther
authors.forename: Sujay P
authors.initials: SP
authors.lastname: Sau
authors.forename: John P
authors.initials: JP
authors.lastname: Verstegen
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Hrdlicka
keywords: DNA recognition; FISH; fluorescent probes; nucleic acid hybridization; oligonucleotides
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