title: Aldehyde-selective Wacker-type oxidation of unbiased alkenes enabled by a nitrite co-catalyst.
abstract: Breaking the rules: Reversal of the high Markovnikov selectivity of Wacker-type oxidations was accomplished using a nitrite co-catalyst. Unbiased aliphatic alkenes can be oxidized with high yield and aldehyde selectivity, and several functional groups are tolerated. (18) O-labeling experiments indicate that the aldehydic O atom is derived from the nitrite salt.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA).
authors.forename: Zachary K
authors.initials: ZK
authors.lastname: Wickens
authors.forename: Bill
authors.initials: B
authors.lastname: Morandi
authors.forename: Robert H
authors.initials: RH
authors.lastname: Grubbs
keywords: alkenes; anti-Markovnikov; oxidation; oxygen; palladium