title: Association between 5p12 genomic markers and breast cancer susceptibility: evidence from 19 case-control studies.
abstract: BACKGROUND
  The association between polymorphisms on 5p12 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two wildly studied polymorphisms (rs10941679 and rs4415084) on 5p12.
  
  
  METHODS
  Databases including Pubmed, EMBASE, Web of Science, EBSCO, and Cochrane Library databases were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.
  
  
  RESULTS
  A total of 19 articles involving 100,083 cases and 163,894 controls were included. An overall random-effects per-allele OR of 1.09 (95% CI: 1.06-1.12; P = 4.5 × 10(-8)) and 1.09 (95% CI: 1.05-1.12; P = 4.2 × 10(-7)) was found for the rs10941679 and rs4415084 polymorphism respectively. Significant results were found in Asians and Caucasians when stratified by ethnicity; whereas no significant associations were found among Africans/African-Americans. Similar results were also observed using dominant or recessive genetic models. In addition, we find both rs4415084 and rs10941679 conferred significantly greater risks of ER-positive breast cancer than of ER-negative tumors.
  
  
  CONCLUSIONS
  Our findings demonstrated that rs10941679-G allele and rs4415084-T allele might be risk-conferring factors for the development of breast cancer, especially in Caucasians and East-Asians.
authors.affiliation: Department of Orthopedics Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Zixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Yushui
authors.initials: Y
authors.lastname: Ma
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Abudouaini
authors.initials: A
authors.lastname: Rewuti
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Da
authors.initials: D
authors.lastname: Fu
authors.forename: Yusong
authors.initials: Y
authors.lastname: Han
mesh_terms: D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000378:metabolism; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D011960:Receptors, Estrogen
references.citation: Breast Cancer Res Treat. 2012 Nov;136(1):209-20
references.pmid: 22965832
references.citation: Breast Cancer Res Treat. 2012 Apr;132(2):711-21
references.pmid: 22160591
references.citation: J Natl Cancer Inst. 2011 Aug 17;103(16):1252-63
references.pmid: 21791674
references.citation: JAMA. 2010 Feb 17;303(7):648-56
references.pmid: 20159873
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2222-31
references.pmid: 21795498
references.citation: J Clin Oncol. 2006 May 10;24(14):2137-50
references.pmid: 16682732
references.citation: Nat Genet. 2009 May;41(5):579-84
references.pmid: 19330030
references.citation: Breast Cancer Res. 2012 Jan 23;14(1):R17
references.pmid: 22269215
references.citation: Lancet Oncol. 2011 May;12(5):477-88
references.pmid: 21514219
references.citation: Carcinogenesis. 2012 Apr;33(4):835-40
references.pmid: 22357627
references.citation: J Natl Cancer Inst. 2005 Mar 16;97(6):439-48
references.pmid: 15770008
references.citation: J Natl Cancer Inst. 2010 Jul 7;102(13):972-81
references.pmid: 20484103
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: J Hum Genet. 2012 Oct;57(10):638-41
references.pmid: 22832384
references.citation: Breast Cancer Res Treat. 2011 Apr;126(3):717-27
references.pmid: 20872241
references.citation: Cell. 2010 Apr 16;141(2):210-7
references.pmid: 20403315
references.citation: Stat Med. 2002 Jun 15;21(11):1539-58
references.pmid: 12111919
references.citation: Gene. 1998 Feb 27;208(2):157-66
references.pmid: 9524256
references.citation: JAMA. 2006 Mar 22;295(12):1379-88
references.pmid: 16551709
references.citation: Breast Cancer Res. 2006;8(5):R56
references.pmid: 17014703
references.citation: Br J Cancer. 2012 Oct 23;107(9):1608-17
references.pmid: 22996614
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2761-4
references.pmid: 19789366
references.citation: Cancer Epidemiol Biomarkers Prev. 2002 Jul;11(7):601-7
references.pmid: 12101106
references.citation: N Engl J Med. 2000 Jul 13;343(2):78-85
references.pmid: 10891514
references.citation: Nat Genet. 2008 Jun;40(6):703-6
references.pmid: 18438407
references.citation: PLoS Genet. 2008 Apr 25;4(4):e1000054
references.pmid: 18437204
references.citation: Breast Cancer Res Treat. 2010 Sep;123(2):525-30
references.pmid: 20140701
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: J Natl Cancer Inst. 2011 Mar 2;103(5):425-35
references.pmid: 21263130
references.citation: Breast Cancer Res. 2012 Mar 27;14(2):R56
references.pmid: 22452962
references.citation: Radiat Res. 2010 Feb;173(2):214-24
references.pmid: 20095854
references.citation: Cancer Res. 2010 Dec 1;70(23):9742-54
references.pmid: 21118973
references.citation: Nat Genet. 2007 Jul;39(7):865-9
references.pmid: 17529974
references.citation: J Biol Chem. 2001 Jun 1;276(22):19363-74
references.pmid: 11279123
references.citation: Hum Mol Genet. 2006 Jun 15;15(12):1995-2002
references.pmid: 16687441
references.citation: Ann Hum Genet. 1955 Jun;19(4):251-3
references.pmid: 14388528
references.citation: Breast Cancer Res Treat. 2013 Jan;137(2):511-22
references.pmid: 23184080
references.citation: Hum Mol Genet. 2010 Jul 15;19(14):2886-97
references.pmid: 20418484
references.citation: JAMA. 2010 Jul 28;304(4):426-34
references.pmid: 20664043
references.citation: Breast Cancer Res Treat. 2009 Sep;117(1):151-9
references.pmid: 19005751
references.citation: FEBS Lett. 2001 Mar 9;492(1-2):166-70
references.pmid: 11248257