title: Palladium-catalyzed asymmetric hydrogenation of α-acyloxy-1-arylethanones.
abstract: First hand: The first example of a palladium-catalyzed asymmetric hydrogenation of α-acyloxy ketones (1) was accomplished to give the hydrogenated products 2 with by far the highest catalytic efficiency in up to quantitative conversions and excellent enantioselectivities. The hydrogenated products could serve as important intermediates for the preparation of many drug candidates. TFE=2,2,2-trifluoroethanol.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240 (China) http://wanbin.sjtu.edu.cn.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Chen
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
authors.forename: Nicholas
authors.initials: N
authors.lastname: Butt
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Dongyang
authors.initials: D
authors.lastname: Fan
authors.forename: Yangang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010165:Palladium
keywords: homogeneous catalysis; hydrogenation; palladium; reduction; synthetic methods