title: Vancomycin-resistant enterococci infection: not just for the transplanted.
abstract: Vancomycin-resistant enterococcal (VRE) blood stream infections (BSIs) pose significant hazards to patients with hematologic malignancy. We compared and examined VRE BSI rates, patient characteristics and clinical outcomes for two cohorts of patients: those who did and did not undergo hematopoietic cell transplant (HCT). In this single institution study, we retrospectively analyzed records of consecutive patients from 1998 through 2011. Over this 14-year period, VRE was identified in 14% of all BSIs in patients with HCT with a cumulative rate of 1.9% (48/2581 BSIs/patients). VRE was identified in 10% of all BSIs in non-HCT patients with a cumulative rate of 1.1% (35/3154 BSIs/patients). Transplant patients who developed VRE BSI tended to be younger, hospitalized more frequently, were exposed to vancomycin therapy frequently, and were more likely to have had a central venous catheter removed. VRE remains a significant cause of morbidity and mortality, as 22 deaths were directly or indirectly attributed to this infection. Both HCT and non-HCT patients are susceptible to VRE infection and are equally at risk for adverse outcomes related to VRE BSI.
authors.affiliation: Division of Hematology-Oncology.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Rosko
authors.forename: Mark
authors.initials: M
authors.lastname: Corriveau
authors.forename: Nuntra
authors.initials: N
authors.lastname: Suwantarat
authors.forename: Lisa
authors.initials: L
authors.lastname: Arfons
authors.forename: Michelle
authors.initials: M
authors.lastname: Treasure
authors.forename: Pamela
authors.initials: P
authors.lastname: Parker
authors.forename: Michael
authors.initials: M
authors.lastname: Jacobs
authors.forename: Pingfu
authors.initials: P
authors.lastname: Fu
authors.forename: Robert
authors.initials: R
authors.lastname: Salata
authors.forename: Hillard M
authors.initials: HM
authors.lastname: Lazarus
mesh_terms: D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000150:complications / Q000382:microbiology; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D065507:Vancomycin-Resistant Enterococci; D055815:Young Adult
keywords: Infectious complications; drug resistance; transplant toxicity