title: Homologous recombination in E3 genes of human adenovirus species D.
abstract: Genes within the E3 transcription unit of human adenoviruses modulate host immune responses to infection. A comprehensive genomics and bioinformatics analysis of the E3 transcription unit for 38 viruses within human adenovirus species D (HAdV-D) revealed distinct and surprising patterns of homologous recombination. Homologous recombination was identified in open reading frames for E3 CR1α, CR1β, and CR1γ, similar to that previously observed with genes encoding the three major structural capsid proteins, the penton base, hexon, and fiber.
authors.affiliation: Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Gurdeep
authors.initials: G
authors.lastname: Singh
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Robinson
authors.forename: Shoaleh
authors.initials: S
authors.lastname: Dehghan
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
authors.forename: David W
authors.initials: DW
authors.lastname: Dyer
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D017503:Adenovirus E3 Proteins / Q000235:genetics*; D000258:Adenovirus Infections, Human / Q000235:genetics* / Q000821:virology; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D019295:Computational Biology; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D016679:Genome, Viral; D059765:Homologous Recombination; D006801:Humans; D010802:Phylogeny
chemical_list: D017503:Adenovirus E3 Proteins; D036022:Capsid Proteins; D004279:DNA, Viral
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