title: Limitations of MIC as the sole criterion in antimicrobial drug dosage regimen design: the need for full characterization of antimicrobial pharmacodynamic profile especially for drug-resistant organisms.
authors.affiliation: Institute of Computational Comparative Medicine, Kansas State University, Manhattan, KS 66506, USA. Electronic address: rgehring@vet.ksu.edu.
authors.forename: Ronette
authors.initials: R
authors.lastname: Gehring
authors.forename: Jim E
authors.initials: JE
authors.lastname: Riviere
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests / Q000379:methods* / Q000662:veterinary; D008954:Models, Biological
chemical_list: D000890:Anti-Infective Agents
keywords: Antimicrobial resistance; Antimicrobial therapy; Mathematical modeling; Pharmacodynamics; Pharmacokinetics