title: Nanopore surface coating delivers nanopore size and shape through conductance-based sizing.
abstract: The performance of nanopore single-molecule sensing elements depends intimately on their physical dimensions and surface chemical properties. These factors underpin the dependence of the nanopore ionic conductance on electrolyte concentration, yet the measured, or modeled, dependence only partially illuminates the details of geometry and surface chemistry. Using the electrolyte-dependent conductance data before and after selective surface functionalization of solid-state nanopores, however, introduces more degrees of freedom and improves the performance of conductance-based nanopore characterizations. Sets of representative nanopore profiles were used to generate conductance data, and the nanopore shape and exact dimensions were identified, through conductance alone, by orders-of-magnitude reductions in the geometry optimization metrics. The optimization framework could similarly be used to evaluate the nanopore surface coating thickness.
authors.affiliation: Department of Chemistry, University of Rhode Island , 51 Lower College Road, Kingston, Rhode Island 02881, United States.
authors.forename: Cameron M
authors.initials: CM
authors.lastname: Frament
authors.forename: Nuwan
authors.initials: N
authors.lastname: Bandara
authors.forename: Jason R
authors.initials: JR
authors.lastname: Dwyer
mesh_terms: D004573:Electrolytes / Q000737:chemistry; D058608:Nanopores; D036103:Nanotechnology; D010316:Particle Size; D013499:Surface Properties
chemical_list: D004573:Electrolytes