title: Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters.
abstract: OBJECTIVE
  To evaluate correlation of exhaled breath condensate (EBC) nitrite and nitrate concentrations with disease severity in cystic fibrosis (CF) patients.
  
  
  BACKGROUND
  Nitrites and nitrates are products of oxidative metabolism of nitric oxide. Impaired metabolism of nitric oxide plays a role in pathogenesis of CF.
  
  
  METHODS
  EBC was collected from 46 stable CF patients and from 21 healthy controls. EBC concentrations of nitrites and nitrates were correlated with parameters of lung disease and nutritional status and with systemic inflammatory markers.
  
  
  RESULTS
  EBC nitrates concentrations in CF patients were lower than in healthy subjects (5.8 vs 14.3 μmol/l, p<0.001). They correlated positively with FEV1 (p=0.025) and serum albumin values (p=0.016) and negatively with chest radiograph Northern score (p=0.015) and serum C-reactive protein values (p=0.005). EBC nitrites concentrations in CF patients did not differ from those in healthy subjects and were not correlated to any studied parameter.
  
  
  CONCLUSIONS
  EBC nitrates concentrations correlate with disease severity in CF patients and are lower than in healthy subjects (Tab. 4, Fig. 1, Ref. 48).
authors.forename: L
authors.initials: L
authors.lastname: Fila
authors.forename: J
authors.initials: J
authors.lastname: Chladek
authors.forename: M
authors.initials: M
authors.lastname: Maly
authors.forename: J
authors.initials: J
authors.lastname: Musil
mesh_terms: D000293:Adolescent; D000328:Adult; D001944:Breath Tests; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009566:Nitrates / Q000032:analysis*; D009573:Nitrites / Q000032:analysis*; D055815:Young Adult
chemical_list: D009566:Nitrates; D009573:Nitrites