title: Octaphlorethol A inhibits the CpG-induced inflammatory response by attenuating the mitogen-activated protein kinase and NF-κB pathways.
abstract: Octaphlorethol A is a phenolic compound isolated from the marine alga Ishige foliacea. In the present study, we investigated the anti-inflammatory activity of octaphlorethol A in CpG-stimulated primary murine bone marrow-derived macrophages and dendritic cells. It exhibited anti-inflammatory activity by regulating the mitogen-activated protein kinase and NF-κB pathways.
authors.affiliation: School of Medicine, Jeju National University.
authors.forename: Zahid
authors.initials: Z
authors.lastname: Manzoor
authors.forename: Vivek Bhakta
authors.initials: VB
authors.lastname: Mathema
authors.forename: Doobyeong
authors.initials: D
authors.lastname: Chae
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Yoo
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Koh
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018899:CpG Islands; D057809:HEK293 Cells; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D016328:NF-kappa B; D010636:Phenols; C572462:octaphlorethol A; D020928:Mitogen-Activated Protein Kinases