title: The effect of injection of EGb 761 into the lateral ventricle on hippocampal cell apoptosis and stem cell stimulation in situ of the ischemic/reperfusion rat model.
abstract: EGb 761 is main active ingredient of the popular and standardized natural extract Ginkgo biloba, which is known to benefit ischemic stroke. In this study we investigated the potential neuroprotective effect of EGb 761 on the hippocampus in the ischemic/reperfusion rat model. Significant recovery of motor function was seen in EGb 761 treated group compared to vehicle treated group. Infarct volume, as revealed by 1% 2,3,5-triphenyltetrazolium chloride (TTC) staining, was significantly reduced, coupled with conspicuous suppression of neurons apoptosis and significant increments in the cell proliferation and migration in hippocampus. This study reports the therapeutic potential of EGb 761 in stroke animals, which could be related to the attenuation of apoptosis and enhancement of neurogenesis.
authors.affiliation: Neurology Department of Affiliated Hospital of Chinese Medicine University of Shandong, Jinan, Shandong 250012, PR China; Neurology Department of the First Affiliated Hospital of Shantou University, Shantou, Guangdong 515041, PR China. Electronic address: slzsunny@126.com.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Sun
authors.forename: Weiduan
authors.initials: W
authors.lastname: Zhuang
authors.forename: Xiangqing
authors.initials: X
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Teng
authors.forename: Fengxia
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D020441:Ginkgo biloba; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007276:Injections, Intraventricular; D020547:Lateral Ventricles; D008297:Male; D055495:Neurogenesis; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D013234:Stem Cells / Q000187:drug effects* / Q000473:pathology; D000096983:Ginkgo Extract
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract
keywords: Apoptosis; EGb 761; Ischemia; Proliferation; Reperfusion; TTC staining