title: Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway.
abstract: As the crucial biological regulators, microRNAs that act by suppressing their target genes are involved in a variety of pathophysiological processes. It is generally accepted that microRNAs are often dysregulated in many types of neoplasm and other human diseases. In neoplasm, microRNAs may function as oncogenes or tumor suppressors. As constitutive activation of the Wnt signaling pathway is a common feature of neoplasm and contributes to its development, progression and metastasis in various cancers, numerous studies have revealed that microRNA-mediated gene regulation are interconnected with the Wnt/β-catenin signaling pathway, forming a Wnt/β-catenin-microRNA regulatory network, which is critical to successful targeting of the Wnt/β-catenin pathway for oncotherapy. In this review, we aim to accumulate recent advances on microRNAs that work in tandem with Wnt/β-catenin signaling in tumorigenesis, with particular focus on how microRNAs affect Wnt/β-catenin activity as well as how microRNAs are regulated through the Wnt/β-catenin pathway.
authors.affiliation: School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicine, Anhui Medical University, Ministry of Education, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Tao-Tao
authors.initials: TT
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D051153:Wnt Proteins; D051176:beta Catenin
keywords: APC; Adenomatous polyposis coli; CK1α; Casein kinase 1α; DKK; Dickkop; Disheveled; Dvl; EZH2; FZD; Frizzled; GSK3β; Glycogen synthase kinase 3β; HCC; Hepatocellular carcinoma; IRS; Insulin receptor substrate; LDL receptor–related protein; LEF; LRP; Lymphoid enhancer-binding factor; NLK; Nemo-like kinase; Neoplasm; Secreted frizzled-related proteins; T-cell factor; TCF; WIF; Wnt inhibitory factor; Wnt/β-catenin signaling; Wnt–microRNA regulatory network; Zeste homologue 2; miRs; microRNA; microRNAs; sFRPs