title: Synthesis, characterization and in vitro biological evaluation of some novel 1,3,5-triazine-Schiff base conjugates as potential antimycobacterial agents.
abstract: A series of some novel 1,3,5-triazine-Schiff base conjugates (1-32) have been synthesized and evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Compounds 4 (4-Methoxy-6-methyl-N-(3,4,5-trimethoxybenzylidene)-1,3,5-triazin-2-amine), 11 (4-Methoxy-6-methyl-N-(2-hydroxy-3-bromo-5-chloro-benzylidene)-1,3,5-triazin-2-amine) and 24 (4-Methoxy-6-methyl-N-(1-(2,5-dihydroxyphenyl)ethylidene)-1,3,5-triazin-2-amine) exhibited a significant activity at 3.125, 6.25 and 6.25μg/mL, respectively, when compared with the antitubercular drugs such as ethambutol (3.125μg/mL), pyrazinamide (6.25μg/mL) and streptomycin (6.25μg/mL) and it could be a potential starting point to develop new lead compounds in the fight against Mycobacterium tuberculosis H37Rv.
authors.affiliation: Pharmaceutical Chemistry Division, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India. Electronic address: vasudevaraoavupati@rediffmail.com.
authors.forename: Vasudeva Rao
authors.initials: VR
authors.lastname: Avupati
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Yejella
authors.forename: Venkateswara Rao
authors.initials: VR
authors.lastname: Parala
authors.forename: Kishore Naidu
authors.initials: KN
authors.lastname: Killari
authors.forename: Venkata Madhava Reddy
authors.initials: VM
authors.lastname: Papasani
authors.forename: Prasad
authors.initials: P
authors.lastname: Cheepurupalli
authors.forename: Venkateswara Rao
authors.initials: VR
authors.lastname: Gavalapu
authors.forename: Bhavani
authors.initials: B
authors.lastname: Boddeda
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D014227:Triazines
keywords: 1,3,5-Triazine–Schiff base conjugate; Alamar Blue assay; Antimycobacterial activity; Mycobacterium tuberculosis H37Rv