title: A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib.
abstract: In this study, two phthalocyanine-erlotinib conjugates linked by an oligoethylene glycol chain have been synthesised and fully characterised. Having erlotinib as the targeting moiety, the two conjugates exhibited high specific affinity to HepG2 cancer cells and tumour tissues, therefore leading to high photodynamic activity.
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350108, P. R. China. liujianyong82@163.com xuejinping66@fzu.edu.cn.
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
authors.forename: Ke
authors.initials: K
authors.lastname: Zheng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Liu
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Xue
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D000069347:Erlotinib Hydrochloride; D019855:Ethylene Glycol / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D054833:Isoindoles; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D017967:Zinc Compounds
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011799:Quinazolines; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D000069347:Erlotinib Hydrochloride; D019855:Ethylene Glycol