title: A beverage of Asiatic plantain extracts alleviated postprandial oxidative stress in overweight hyperlipidemic subjects challenged with a high-fat meal: a preliminary study.
abstract: There is emerging interest in the potential of the phenolic compounds of Asiatic plantain (Plantago asiatica L.) to attenuate in vitro and in vivo oxidative stress. We hypothesized that a single administration of Asiatic plantain beverage may exert protective effects against postprandial oxidative stress. This preliminary study was designed to compare the ability of different doses of Asiatic plantain beverage to mitigate the postprandial effects of a high-fat meal on the oxidation of lipids and DNA in overweight hyperlipidemic subjects. In a randomized, double-blind, placebo-controlled parallel design (n = 10/group), 40 subjects were administered a single high-fat meal with either a placebo or 1 of 3 Asiatic plantain extract beverages (low, intermediate, or high dose). Blood samples were obtained at fasting and 60, 120, 240, and 360 minutes (total of 5 samples) after intervention. The data showed a tendency for plasma free fatty acid levels to decrease in response to high-dose Asiatic plantain at all time points. Plasma oxidized low-density lipoprotein levels were significantly reduced with high-dose Asiatic plantain at 120 minutes (P = .0251 vs placebo). A comet assay revealed that DNA damage in lymphocytes was significantly decreased by Asiatic plantain at 360 minutes (P = .0225 vs placebo). There were no treatment differences in triglyceride or malondialdehyde levels. The maximum suppression was achieved with a high dose (20 g Asiatic plantain extract/80 mL). These results suggest that by protecting low-density lipoprotein and DNA, an Asiatic plantain beverage may be useful to enhance antioxidant.
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Yeni
authors.initials: Y
authors.lastname: Lim
authors.forename: Kwang Won
authors.initials: KW
authors.lastname: Lee
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Oran
authors.initials: O
authors.lastname: Kwon
mesh_terms: D000328:Adult; D001628:Beverages; D020552:Comet Assay; D004249:DNA Damage; D059305:Diet, High-Fat; D004311:Double-Blind Method; D005215:Fasting; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D062407:Meals; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010943:Plantago / Q000737:chemistry*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; C099252:oxidized low density lipoprotein
keywords: Asiatic plantain; BMI; Comet assay; DBP; FFA; HDL-C; High-fat meal; Human; LDL-C; MDA; Oxidized LDL; Postprandial oxidative stress; TC; TG; body mass index; diastolic blood pressure; free fatty acid; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; malondialdehyde; ox-LDL; oxidized low-density lipoprotein; total cholesterol; triglycerides