title: Coexistence of scleroderma with multiple myeloma: a rare association.
abstract: Coexistence of scleroderma with multiple myeloma (MM) is an unusual finding with unclear significance. Only 13 cases of MM with scleroderma have been reported until now. We report a case of a 24-year-old man with 8-year history of progressive thickening of skin all over the body. Histopathology of skin lesion was consistent with scleroderma. Bone marrow biopsy showed interstitial and focal increase in plasma cells and increased bone marrow fibrosis. Skeletal survey showed osteopenia, but no osteolytic lesion or fracture. The patient was diagnosed as scleroderma with coexistence of immunoglobulin A, κMM. The patient recovered with improvement of skin lesions after 9 months of therapy with thalidomide and dexamethasone.
authors.affiliation: Laboratory Oncology Unit, DR BR A IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Smeeta
authors.initials: S
authors.lastname: Gajendra
authors.forename: Richa
authors.initials: R
authors.lastname: Gupta
authors.forename: Ritu
authors.initials: R
authors.lastname: Gupta
authors.forename: Lalit
authors.initials: L
authors.lastname: Kumar
mesh_terms: D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D035583:Rare Diseases / Q000150:complications* / Q000276:immunology; D012594:Scleroderma, Localized / Q000150:complications* / Q000276:immunology; D055815:Young Adult
chemical_list: D007070:Immunoglobulin A
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