title: The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome.
abstract: BACKGROUND
  The Pro12Ala polymorphism in the peroxisome Proliferator-activated receptor-gamma2 PPARγ2) gene that account for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain elusive.
  
  
  OBJECTIVE
  To explore the association between PPARγ2 gene pro12ala polymorphism and the metabolic characteristics in Chinese women with PCOS.
  
  
  METHODS
  PPARγ2 gene Pro12Ala polymorphism was assayed by PCR/RFLP methods in 120 Chinese women with PCOS and 118 normal subjects. All subjects were examined by anthropometry, lipid profile, sex hormone, oral glucose tolerance tests and insulin tolerance tests.
  
  
  RESULTS
  In PCOS patients, women with the non-Pro/Pro genotypes of the PPARγ2 gene Pro12Ala polymorphism showed statistically significantly higher fasting triglycerides (TG) levels and WHR value than those with the Pro/Pro genotype (P=.006 for both). There was no significant difference with PPARγ2 Pro12Ala polymorphism distributions between Chinese Han women with PCOS and controls.
  
  
  CONCLUSIONS
  PPARγ2 gene Pro12Ala polymorphism was not supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of serum fasting TG levels and fat-deposition in abdomen, respectively.
authors.affiliation: Department of Internal Medicine Renji Hospital, Division of Endocrinology and Metabolism, Shanghai Jiaotong University School of Medicine 1630 Dongfang Road, Pudong, Shanghai, 200127, China.
authors.forename: Jiejin
authors.initials: J
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Gong
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Tao
mesh_terms: D050154:Adiposity / Q000208:ethnology / Q000235:genetics; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D056128:Obesity, Abdominal / Q000208:ethnology / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics*; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D015415:Biomarkers; D047495:PPAR gamma; D014280:Triglycerides
keywords: Polycystic ovary syndrome; central obesity; hypertriglyceridemia; peroxisome proliferator-activated receptor-gamma2; polymorphism
references.citation: J Clin Endocrinol Metab. 2004 Oct;89(10):5110-5
references.pmid: 15472214
references.citation: Clin Exp Pharmacol Physiol. 2008 Feb;35(2):187-91
references.pmid: 17941898
references.citation: Annu Rev Genomics Hum Genet. 2003;4:257-91
references.pmid: 14527304
references.citation: Lancet. 1985 Dec 21-28;2(8469-70):1375-9
references.pmid: 2867389
references.citation: Circulation. 2000 Jul 11;102(2):179-84
references.pmid: 10889128
references.citation: Hormones (Athens). 2009 Oct-Dec;8(4):267-72
references.pmid: 20045799
references.citation: Atherosclerosis. 1980 Sep;37(1):143-50
references.pmid: 7426083
references.citation: J Clin Endocrinol Metab. 1999 Nov;84(11):4006-11
references.pmid: 10566641
references.citation: Fertil Steril. 2006 May;85(5):1536-40
references.pmid: 16600233
references.citation: Recent Prog Horm Res. 2001;56:295-308
references.pmid: 11237218
references.citation: Hum Reprod. 2005 Jun;20(6):1590-5
references.pmid: 15705622
references.citation: J Clin Endocrinol Metab. 2002 Feb;87(2):772-5
references.pmid: 11836319
references.citation: Metabolism. 2007 Oct;56(10):1345-9
references.pmid: 17884443
references.citation: Obstet Gynecol Surv. 2006 Feb;61(2):125-35
references.pmid: 16433936
references.citation: Science. 2007 Jun 1;316(5829):1341-5
references.pmid: 17463248
references.citation: Diabetologia. 1999 Sep;42(9):1033-49
references.pmid: 10447513
references.citation: Clin Endocrinol (Oxf). 2005 May;62(5):573-9
references.pmid: 15853827
references.citation: Ann N Y Acad Sci. 2002 Jun;967:265-73
references.pmid: 12079854
references.citation: J Clin Endocrinol Metab. 1999 Jun;84(6):1897-9
references.pmid: 10372683
references.citation: Fertil Steril. 2004 Jan;81(1):19-25
references.pmid: 14711538
references.citation: Biochem Biophys Res Commun. 1997 Dec 18;241(2):270-4
references.pmid: 9425261
references.citation: Metabolism. 2004 Dec;53(12):1538-43
references.pmid: 15562396
references.citation: Diabetes Care. 1996 Oct;19(10):1138-41
references.pmid: 8886564
references.citation: Eur J Clin Nutr. 2013 Jun;67(6):573-85
references.pmid: 23511854
references.citation: Diabetes. 1998 Apr;47(4):507-14
references.pmid: 9568680
references.citation: Clin Chem. 2006 Oct;52(10):1920-5
references.pmid: 16916989
references.citation: Nat Genet. 1998 Nov;20(3):284-7
references.pmid: 9806549
references.citation: Diabet Med. 2006 May;23(5):469-80
references.pmid: 16681555
references.citation: Gynecol Obstet Invest. 2010;70(1):1-7
references.pmid: 20130411