title: A template for new drugs against Alzheimer's disease.
abstract: Alzheimer's disease (AD) is associated with the deposition of β-amyloid (Aβ) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of Aβ fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.
authors.affiliation: Institute of Neuropathology, University Hospital Zurich, 8091 Zurich, Switzerland. Electronic address: adriano.aguzzi@usz.ch.
authors.forename: Adriano
authors.initials: A
authors.lastname: Aguzzi
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Gitler
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000737:chemistry*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans
chemical_list: D000682:Amyloid