title: 3-(2,5-Di-methyl-phen-yl)-8-meth-oxy-2-oxo-1-aza-spiro-[4.5]dec-3-en-4-yl 3-(2-bromo-4-fluoro-phen-yl)acrylate.
abstract: In the title compound, C27H27BrFNO4, which is an inhibitor of acetyl-CoA carboxyl-ase, the cyclo-hexane ring displays a chair comformation with the spiro-C and meth-oxy-bearing C atoms deviating by 0.681 (7) and -0.655 (1) Å, resppectively, from the mean plane formed by the other four C atoms of the spiro-C6 ring. The mean planes of the cyclo-hexane and 2-bromo-4-fluoro-phenyl rings are nearly perpendicular to that of the pyrrolidine ring, making dihedral angles 89.75 (6) and 87.60 (9)°, respectively. In the crystal, mol-ecules are linked via pairs of N-H⋯O hydrogen bonds, forming inversion dimers.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China.
authors.forename: Bing-Rong
authors.initials: BR
authors.lastname: Xu
authors.forename: Xing-Rui
authors.initials: XR
authors.lastname: He
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Cheng
authors.forename: Jin-Hao
authors.initials: JH
authors.lastname: Zhao
references.citation: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references.pmid: 18156677
references.citation: Bioorg Med Chem. 2008 Apr 15;16(8):4203-21
references.pmid: 18334299
references.citation: J Agric Food Chem. 2012 May 16;60(19):4779-87
references.pmid: 22531003