title: Evidence for the involvement of epigenetics in the progression of renal fibrogenesis.
abstract: Epigenetics are omnipresent in eukaryotic cells and influence cell differentiation and maintenance of cell metabolism in health and disease. Here, we discuss how the 'second genetic code' impacts the fate of the injured kidney. We provide a glimpse of how recent insights into epigenetic mechanisms of chronic kidney disease might lead to novel diagnostic and therapeutic tools.
authors.affiliation: Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Tampe
authors.forename: Michael
authors.initials: M
authors.lastname: Zeisberg
mesh_terms: D000818:Animals; D018450:Disease Progression; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000235:genetics*
keywords: epigenetic; histone modification; hydroxymethylation; kidney fibrosis; methylation