title: Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase.
abstract: A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 μM.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Korea.
authors.forename: Jing Lu
authors.initials: JL
authors.lastname: Liang
authors.forename: Umair
authors.initials: U
authors.lastname: Javed
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
mesh_terms: D000363:Agaricales / Q000201:enzymology; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011714:Pyrans / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D019666:Rubiaceae
chemical_list: D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D011714:Pyrans; C046245:rubimaillin; D014442:Monophenol Monooxygenase