title: Paraneoplastic cerebellar degeneration with anti-Yo antibodies associated with metastatic uveal melanoma.
abstract: Paraneoplastic cerebellar degeneration (PCD) is characterized by subacute development of pancerebellar dysfunction as a remote effect of a systemic cancer and usually develops in patients affected by gynecological tumors. Uveal melanoma is a very rare disease with a severe prognosis. A 58-year-old man affected by uveal melanoma developed anti-Yo positive paraneoplastic cerebellar degeneration (PCD) 42 months after the initial diagnosis. The onset and worsening of the neurological symptoms were parallel to the course of liver metastasis. To our knowledge this is the first case of PCD in a patient with uveal melanoma. We speculate that the cerebellar degeneration-related protein 2 (CDR2), to which the anti-Yo antibodies are directed, may have been expressed in melanoma cells and conferred proliferative advantage to the disease.
authors.affiliation: Melanoma Cancer Unit-SSD, Veneto Oncology Institute, 64 Gattamelata St, 35128 Padova, Italy. Electronic address: sara.valpione@ioveneto.it.
authors.forename: Sara
authors.initials: S
authors.lastname: Valpione
authors.forename: Marco
authors.initials: M
authors.lastname: Zoccarato
authors.forename: Raffaele
authors.initials: R
authors.lastname: Parrozzani
authors.forename: Jacopo
authors.initials: J
authors.lastname: Pigozzo
authors.forename: Bruno
authors.initials: B
authors.lastname: Giometto
authors.forename: Francesco
authors.initials: F
authors.lastname: Laveder
authors.forename: Camillo
authors.initials: C
authors.lastname: Aliberti
authors.forename: Vanna
authors.initials: V
authors.lastname: Chiarion-Sileni
mesh_terms: D000906:Antibodies / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020362:Paraneoplastic Cerebellar Degeneration / Q000097:blood* / Q000150:complications*; D015898:Tomography Scanners, X-Ray Computed; D014604:Uveal Neoplasms / Q000150:complications* / Q000473:pathology / Q000556:secondary; D000098943:Uveal Melanoma
chemical_list: D000906:Antibodies; C095184:CDR2 protein, human; D009419:Nerve Tissue Proteins
keywords: Anti-Yo antibodies; CDR(2); Cancer; Paraneoplastic cerebellar degeneration; Paraneoplastic syndrome; Uveal melanoma