title: Catalyst-controlled aliphatic C-H oxidations with a predictive model for site-selectivity.
abstract: Selective aliphatic C-H bond oxidations may have a profound impact on synthesis because these bonds exist across all classes of organic molecules. Central to this goal are catalysts with broad substrate scope (small-molecule-like) that predictably enhance or overturn the substrate's inherent reactivity preference for oxidation (enzyme-like). We report a simple small-molecule, non-heme iron catalyst that achieves predictable catalyst-controlled site-selectivity in preparative yields over a range of topologically diverse substrates. A catalyst reactivity model quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst.
authors.affiliation: Department of Chemistry, University of Illinois Urbana-Champaign , Urbana, Illinois 61801, United States.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Gormisky
authors.forename: M Christina
authors.initials: MC
authors.lastname: White