title: Blockade of B2 receptors attenuates the responses of group III afferents to static contraction.
abstract: Recent evidence has been presented demonstrating that group III mechanoreceptors comprise an important part of the sensory arm of the exercise pressor reflex, which in turn functions to increase arterial blood flow to contracting skeletal muscles. Although group III afferents are stimulated by mechanical distortion of their receptive fields, they are also stimulated by bradykinin, which is produced by skeletal muscle when it contracts. Moreover, blockade of B (bradykinin)2 receptors has been shown to decrease the magnitude of the exercise pressor reflex. Nevertheless, the effect of blockade of B2 receptors on responses of group III afferents to contraction is not known. We therefore determined the effect of B2 receptor blockade with HOE 140 (40μg/kg) on the responses to both static and intermittent contraction of group III afferents with endings in the triceps surae muscle of decerebrated unanesthetized cats. We found that HOE 140 significantly attenuated (P=0.04) the responses of 14 group III afferents to static contraction, but did not significantly attenuate (P=0.16) the responses of 16 group III afferents to intermittent contraction. The attenuation induced by HOE 140 was present throughout the static contraction period, and led us to speculate that blockade of B2 receptors on the endings of group III afferents decreased their sensitivity to mechanical events occurring in the working muscles.
authors.affiliation: Heart and Vascular Institute, Penn State College of Medicine, Hershey, PA 17033, United States. Electronic address: aleal@hmc.psu.edu.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Leal
authors.forename: Audrey J
authors.initials: AJ
authors.lastname: Stone
authors.forename: Katsuya
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McCord
authors.forename: Marc P
authors.initials: MP
authors.lastname: Kaufman
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology; D065094:Bradykinin B2 Receptor Antagonists; D002415:Cats; D003655:Decerebrate State; D004558:Electric Stimulation; D005260:Female; D008465:Mechanoreceptors / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation / Q000502:physiology
chemical_list: D065094:Bradykinin B2 Receptor Antagonists; C065679:icatibant; D001920:Bradykinin
keywords: Bradykinin; Exercise pressor reflex; HOE 140; Locomotion; Mechanoreception
references.citation: J Appl Physiol (1985). 1986 Jul;61(1):271-9
references.pmid: 2426240
references.citation: J Appl Physiol (1985). 2003 Apr;94(4):1437-45
references.pmid: 12482762
references.citation: J Physiol. 1971 Jul;215(3):789-804
references.pmid: 5090995
references.citation: Annu Rev Physiol. 1983;45:229-42
references.pmid: 6342515
references.citation: Circ Res. 1982 Jan;50(1):133-9
references.pmid: 7053873
references.citation: Am J Physiol. 1987 Nov;253(5 Pt 2):H1199-207
references.pmid: 3688260
references.citation: Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1166-74
references.pmid: 23417862
references.citation: J Appl Physiol (1985). 2010 Oct;109(4):966-76
references.pmid: 20634355
references.citation: J Appl Physiol (1985). 1990 Mar;68(3):861-7
references.pmid: 2111312
references.citation: J Physiol. 1977 May;267(1):75-88
references.pmid: 141496
references.citation: Physiol Rev. 2012 Oct;92(4):1699-775
references.pmid: 23073630
references.citation: J Physiol. 2009 Feb 15;587(Pt 4):873-82
references.pmid: 19103679
references.citation: Am J Physiol. 1999 Apr;276(4):H1399-403
references.pmid: 10199868
references.citation: J Appl Physiol (1985). 2007 Jul;103(1):190-4
references.pmid: 17478607
references.citation: J Appl Physiol (1985). 1991 Nov;71(5):1837-42
references.pmid: 1761481
references.citation: J Appl Physiol (1985). 1985 Jul;59(1):56-63
references.pmid: 3861607
references.citation: J Physiol. 1972 Jul;224(1):173-86
references.pmid: 5039977
references.citation: J Appl Physiol (1985). 1990 Oct;69(4):1225-30
references.pmid: 2124582
references.citation: Circulation. 2005 Oct 11;112(15):2293-300
references.pmid: 16216976
references.citation: Am J Physiol. 1990 Sep;259(3 Pt 2):H745-50
references.pmid: 2118727
references.citation: J Appl Physiol (1985). 1993 Nov;75(5):2061-8
references.pmid: 8307860
references.citation: J Physiol. 1989 Oct;417:13-24
references.pmid: 2621589
references.citation: Brain Res. 1997 Jan 2;744(1):175-8
references.pmid: 9030430
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1983 Jul;55(1 Pt 1):105-12
references.pmid: 6309712
references.citation: J Neurophysiol. 1993 Apr;69(4):1053-9
references.pmid: 8492148
references.citation: J Physiol. 1970 Jun;208(2):261-78
references.pmid: 5500722
references.citation: J Appl Physiol (1985). 1988 Jun;64(6):2306-13
references.pmid: 3136123
references.citation: Pharmacol Rev. 1998 Sep;50(3):357-86
references.pmid: 9755287
references.citation: Circ Res. 1981 Jun;48(6 Pt 2):I76-86
references.pmid: 7014025
references.citation: J Physiol. 1988 Apr;398:49-63
references.pmid: 3392680
references.citation: Eur J Pharmacol. 2003 May 23;469(1-3):29-36
references.pmid: 12782182
references.citation: Circ Res. 1989 Mar;64(3):592-9
references.pmid: 2917383
references.citation: J Physiol. 2011 Aug 1;589(Pt 15):3855-66
references.pmid: 21646407
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1984 Sep;57(3):644-50
references.pmid: 6092310
references.citation: J Appl Physiol (1985). 1989 Jun;66(6):2721-4
references.pmid: 2501290
references.citation: J Physiol. 2007 Jun 15;581(Pt 3):1271-82
references.pmid: 17395635
references.citation: Br J Pharmacol. 1996 Nov;119(5):1054-62
references.pmid: 8922758
references.citation: Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H751-7
references.pmid: 16183724
references.citation: Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H866-73
references.pmid: 17012352