title: Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats.
abstract: The present study was undertaken to elucidate the effect of Perilla frutescens fixed oil on experimental esophagitis in albino rats. A group of rats (n = 6), treated with control vehicle (0.9% NaCl in double distilled water, 3 mL/kg, i.p.) and Perilla frutescens fixed oil (100%) (1, 2, and 3 mL/kg, i.p.), or pantoprazole (30 mg/kg, i.p.), were subjected to pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with fixed oil significantly inhibited the gastric secretion, total acidity, and esophagitis index. The oil also helped to restore the altered levels of oxidative stress parameters to normal. The present study also makes evident the in vitro antihistaminic and anticholinergic activity of alpha linolenic acid (ALA) (18 : 3, n - 3) on isolated rat ileum preparation. The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic), and antioxidant activity of the oil was attributed for its efficacy in reflux esophagitis.
authors.affiliation: Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (Central University), Vidya Vihar, Rai Bareli Road, Lucknow 226025, India.
authors.forename: Ekta
authors.initials: E
authors.lastname: Arya
authors.forename: Sudipta
authors.initials: S
authors.lastname: Saha
authors.forename: Shubhini A
authors.initials: SA
authors.lastname: Saraf
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaithwas
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004941:Esophagitis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D000077402:Pantoprazole; D031344:Perilla frutescens / Q000737:chemistry*; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000008:administration & dosage
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; D017962:alpha-Linolenic Acid; D000077402:Pantoprazole; D002374:Catalase; D013482:Superoxide Dismutase
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