title: Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.
abstract: Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
authors.affiliation: Haematology Unit, Department of Medical and Experimetal Oncology, IRCCS National Cancer Research Centre "Giovanni Paolo II", Bari, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Minoia
authors.forename: Carmela
authors.initials: C
authors.lastname: Quero
authors.forename: Mariaconsilia
authors.initials: M
authors.lastname: Asselti
authors.forename: Ida
authors.initials: I
authors.lastname: Galise
authors.forename: Alessia L
authors.initials: AL
authors.lastname: Marzano
authors.forename: Angela
authors.initials: A
authors.lastname: Iacobazzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Rana
authors.forename: Francesca
authors.initials: F
authors.lastname: Merchionne
authors.forename: Simona
authors.initials: S
authors.lastname: Serratì
authors.forename: Giacoma
authors.initials: G
authors.lastname: De Tullio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Quintana
authors.forename: Michela
authors.initials: M
authors.lastname: Casiello
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maiorano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simone
authors.forename: Francesco A
authors.initials: FA
authors.lastname: Zito
authors.forename: Pasquale
authors.initials: P
authors.lastname: Iacopino
authors.forename: Attilio
authors.initials: A
authors.lastname: Guarini
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis* / Q000235:genetics; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000378:metabolism; D012008:Recurrence
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins
keywords: angiogenesis; hypoxia-inducible factor-1α; indolent non-Hodgkin lymphomas; pathogenesis; relapse/progression