title: Feasibility of complete video-assisted thoracoscopic surgery following neoadjuvant therapy for locally advanced non-small cell lung cancer.
abstract: OBJECTIVE
  To explore the feasibility of complete video-assisted thoracoscopic surgery (c-VATS) following neoadjuvant therapy (chemotherapy, targeted therapy and radiotherapy, either alone or in combination) for the treatment of patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The clinical data of 43 NSCLC patients undergoing c-VATS following neoadjuvant therapy were retrospectively analyzed, including the preoperative functional indicators, staging, concurrent diseases, surgical techniques, operation time, number of lymph nodes dissected and postoperative drainage time and quantity, postoperative hospital stay, postoperative complications, and survival.
  
  
  RESULTS
  From January 2006 to March 2012, a total of 43 patients with stage IIA-IIIB NSCLC were included in this study (IIIA: 27 cases, 62.8%; IIIB: 11 cases, 25.6%), including 32 males (74.4%) and 11 females (25.6%). Forty-two patients were operated successfully, 28 underwent pulmonary lobectomies (including 9 bronchial sleeve resections), 5 had double lobectomies, 5 had wedge resections, and 4 had total pneumonectomies. Seven patients were referred to undergo Hybrid VATS (7/42, 16.7%). The mean length of the operation was 160.48±16.52 min (range, 130-180 min); the intraoperative blood loss was 253.57±117.08 mL; the number of lymph nodes dissected was 16.88±10.93; the postoperative drainage time was 1-7 d (mean: 2.62±0.96 d); and the postoperative hospital stay was 3-7 d (mean: 5.45±1.30 d). The incidence of postoperative complications was 9.5% (4/42), and the perioperative mortality was 2.4% (1/42). The 1-, 2-, and 3-year overall survival rates were 94%, 79%, and 65%, respectively.
  
  
  CONCLUSIONS
  c-VATS following neoadjuvant therapy is safe and feasible for the treatment of locally advanced NSCLC.
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China; ; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Chen
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Yin
authors.forename: Wenlong
authors.initials: W
authors.lastname: Shao
authors.forename: Xinguo
authors.initials: X
authors.lastname: Xiong
authors.forename: Jianxing
authors.initials: J
authors.lastname: He
keywords: Non-small-cell lung cancer (NSCLC); complete video-assisted thoracoscopic surgery (c-VATS); neoadjuvant chemotherapy; targeted therapy
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