title: [A meta-analysis on efficacy of intra-aortic balloon pump therapy in patients with acute myocardial infarction].
abstract: OBJECTIVE
  To analyze the efficacy and safety of intra-aortic balloon pump (IABP) therapy in patients with acute myocardial infarction(AMI) based on the meta-analysis.
  
  
  METHODS
  Eligible published randomized controlled clinical research (RCT) were retrieved in the Pubmed, EMBase, Cochrane, China biological medical literature, Wanfang, VIP and CNKI database from 1980 to April 2, 2012. The analysis was performed with the software of RevMan 5.1.
  
  
  RESULTS
  Thirteen RCTs with 1958 patients (AMI with IABP therapy, n = 970,without IABP therapy, n = 988) were included. The 30-day mortality between the two groups was similar (RR = 0.77, 95%CI 0.58-1.03, P = 0.08), but the 30-day mortality in the cardiac shock subgroup was significantly lower in IABP group than in without IABP group (RR = 0.65, 95%CI 0.44-0.97, P = 0.04). The 6-month mortality was significantly lower in IABP group than in without IABP group (RR = 0.72, 95%CI 0.55-0.94, P = 0.02). The incidence of major bleeding was significantly higher in IABP group than in without IABP group (RR = 1.43, 95%CI 1.16-1.75, P < 0.01).
  
  
  CONCLUSIONS
  IABP therapy is effective to reduce earlier mortality post AMI, particularly for patients with cardiac shock.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xian-rui
authors.initials: XR
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Shao-jie
authors.initials: SJ
authors.lastname: Chen
authors.forename: Xiao-ge
authors.initials: XG
authors.lastname: Zhang
authors.forename: Yue-hui
authors.initials: YH
authors.lastname: Ying
mesh_terms: D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D009203:Myocardial Infarction / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome