title: Diet-regulated anxiety.
abstract: A substantial proportion of noncommunicable disease originates in habitual overconsumption of calories, which can lead to weight gain and obesity and attendant comorbidities. At the other end of the spectrum, the consequences of undernutrition in early life and at different stages of adult life can also have major impact on wellbeing and quality of life. To help address some of these issues, greater understanding is required of interactions with food and contemporary diets throughout the life course and at a number of different levels: physiological, metabolic, psychological, and emotional. Here we review the current literature on the effects of dietary manipulation on anxiety-like behaviour. This evidence, assembled from study of preclinical models of diet challenge from gestation to adult life, supports a role for diet in the important connections between psychology, physiology, and behaviour. Analogous processes in the human population in our current obesogenic environment are likely to contribute to individual and societal challenges in this area.
authors.affiliation: Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Murphy
authors.forename: Julian G
authors.initials: JG
authors.lastname: Mercer
references.citation: Int J Dev Neurosci. 2012 Feb;30(1):39-45
references.pmid: 22023958
references.citation: Physiol Behav. 2006 Aug 30;89(1):53-61
references.pmid: 16545403
references.citation: Public Health Nutr. 1999 Sep;2(3A):403-9
references.pmid: 10610080
references.citation: Int J Obes (Lond). 2008 Mar;32(3):550-7
references.pmid: 17938639
references.citation: Eur J Pharmacol. 2008 May 6;585(1):31-7
references.pmid: 18342851
references.citation: Physiol Behav. 2011 Apr 18;103(1):104-10
references.pmid: 21168428
references.citation: Brain Res. 2012 Aug 27;1470:24-34
references.pmid: 22765913
references.citation: Neuroscience. 2013 Jun 14;240:1-12
references.pmid: 23454542
references.citation: Psychopharmacology (Berl). 2010 Dec;212(4):585-95
references.pmid: 20730419
references.citation: Appetite. 2012 Jun;58(3):842-6
references.pmid: 22326881
references.citation: Neuroendocrinology. 2002 Oct;76(4):243-53
references.pmid: 12411741
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R99-105
references.pmid: 17428895
references.citation: Physiol Behav. 2012 Jun 25;106(4):491-8
references.pmid: 22484113
references.citation: Physiol Behav. 2014 Jan 17;123:236-42
references.pmid: 23085399
references.citation: Appetite. 2008 Jan;50(1):1-11
references.pmid: 17707947
references.citation: J Biol Chem. 2007 Dec 14;282(50):36275-82
references.pmid: 17942401
references.citation: Endocr Rev. 1998 Jun;19(3):269-301
references.pmid: 9626555
references.citation: Neuroscience. 2010 Oct 13;170(2):580-8
references.pmid: 20654704
references.citation: J Psychopharmacol. 2011 Nov;25(11):1415-33
references.pmid: 20530588
references.citation: Physiol Behav. 1996 Sep;60(3):1039-42
references.pmid: 8873290
references.citation: Psychopharmacology (Berl). 2009 Jun;204(3):431-43
references.pmid: 19205668
references.citation: Obesity (Silver Spring). 2007 Apr;15(4):798-808
references.pmid: 17426312
references.citation: Behav Brain Res. 2010 Mar 17;208(1):72-9
references.pmid: 19896506
references.citation: Obes Facts. 2012;5(2):277-87
references.pmid: 22647308
references.citation: Neuropsychopharmacology. 2008 Feb;33(3):524-35
references.pmid: 17443124
references.citation: Pharmacol Ther. 2011 Jul;131(1):61-79
references.pmid: 21447358
references.citation: FASEB J. 2010 Jun;24(6):2104-15
references.pmid: 20124437
references.citation: Obes Res. 2003 Apr;11(4):496-506
references.pmid: 12690076
references.citation: Int J Dev Neurosci. 2011 Dec;29(8):785-93
references.pmid: 22004940
references.citation: BMC Psychiatry. 2012 Feb 14;12:10
references.pmid: 22333556
references.citation: Psychoneuroendocrinology. 2010 Nov;35(10):1553-64
references.pmid: 20594764
references.citation: Neuroendocrinology. 2004;79(4):163-73
references.pmid: 15153750
references.citation: Mol Endocrinol. 2013 Jul;27(7):1091-102
references.pmid: 23676213
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20016-20
references.pmid: 19901333
references.citation: J Physiol. 2005 May 15;565(Pt 1):9-17
references.pmid: 15705647
references.citation: Depress Anxiety. 2006;23(6):377-87
references.pmid: 16823859
references.citation: Psychoneuroendocrinology. 2009 Jan;34(1):38-49
references.pmid: 18842344
references.citation: Pediatrics. 2012 Feb;129(2):330-7
references.pmid: 22232312
references.citation: Brain Res Mol Brain Res. 2004 May 19;124(2):134-42
references.pmid: 15135221
references.citation: J Pharmacol Toxicol Methods. 1993 Jun;29(3):129-38
references.pmid: 8103377
references.citation: Physiol Behav. 2008 Jun 9;94(3):309-15
references.pmid: 18325546
references.citation: J Neuroendocrinol. 1994 Oct;6(5):479-501
references.pmid: 7827618
references.citation: Physiol Behav. 2011 Jul 6;103(5):487-92
references.pmid: 21497614
references.citation: Endocrinology. 2007 Nov;148(11):5531-40
references.pmid: 17673512
references.citation: Depress Anxiety. 2012 May;29(5):355-8
references.pmid: 22553005
references.citation: J Exp Psychol Anim Behav Process. 2010 Apr;36(2):313-9
references.pmid: 20384410
references.citation: Physiol Behav. 2011 May 3;103(2):164-72
references.pmid: 21241725
references.citation: Eur J Neurosci. 2009 Nov;30(9):1739-48
references.pmid: 19878278
references.citation: Behav Brain Res. 2011 Feb 2;217(1):134-41
references.pmid: 20974195
references.citation: FASEB J. 2011 Jul;25(7):2167-79
references.pmid: 21427213
references.citation: Int J Obes (Lond). 2013 Mar;37(3):382-9
references.pmid: 22508336
references.citation: Pharmacol Biochem Behav. 1996 May;54(1):21-30
references.pmid: 8728535
references.citation: Physiol Behav. 2008 Sep 3;95(1-2):108-13
references.pmid: 18602652
references.citation: Psychopharmacology (Berl). 1991;103(4):513-8
references.pmid: 1676529
references.citation: Med Care. 2009 Jan;47(1):105-14
references.pmid: 19106738
references.citation: Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R86-92
references.pmid: 10896868
references.citation: Physiol Behav. 2011 May 3;103(2):157-63
references.pmid: 21241726
references.citation: Am J Clin Nutr. 2011 Dec;94(6 Suppl):2006S-2011S
references.pmid: 22089441
references.citation: Biochem J. 2010 Apr 14;427(3):333-47
references.pmid: 20388123
references.citation: Physiol Behav. 2009 Dec 7;98(5):563-9
references.pmid: 19751751
references.citation: Psychoneuroendocrinology. 2010 Jun;35(5):717-28
references.pmid: 19939573
references.citation: J Neurosci. 2010 Mar 10;30(10):3826-30
references.pmid: 20220017
references.citation: Psychopharmacology (Berl). 2008 Mar;197(1):83-94
references.pmid: 18004547
references.citation: Life Sci. 2007 Jun 27;81(3):198-203
references.pmid: 17574275
references.citation: Genes Brain Behav. 2009 Mar;8(2):193-202
references.pmid: 19077174
references.citation: Neuroendocrinology. 2011;93(1):1-8
references.pmid: 21079387
references.citation: Peptides. 2010 Apr;31(4):736-56
references.pmid: 20026211
references.citation: Acta Neurobiol Exp (Wars). 2004;64(4):439-48
references.pmid: 15586660
references.citation: Behav Brain Res. 2012 Aug 1;233(2):398-404
references.pmid: 22633920
references.citation: Neuroscience. 2011 Nov 10;195:80-8
references.pmid: 21893165
references.citation: Brain Res. 2008 Oct 27;1237:12-24
references.pmid: 18694740
references.citation: Mol Psychiatry. 2012 Feb;17(2):132-41
references.pmid: 21788943
references.citation: Neuroscience. 2011 Sep 29;192:351-60
references.pmid: 21742017