title: [Long term outcome of atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation].
abstract: OBJECTIVE
  The outcome of atrial fibrillation patients with genetic mutations post ablation was not well evaluated.
  
  
  RESULTS
  Three atrial fibrillation patients with evidence of mutations in KCNA5 and NPPA post successful circumferential pulmonary vein ablation were included. Mutation in KCNA5 was found in one male patient with paroxysmal atrial fibrillation. He was free of atrial fibrillation post ablation after 46 months follow-up. Mutations in NPPA were found in two male patients with persistent atrial fibrillation and they were free from atrial fibrillation after 64 months and 38 months follow-up post circumferential pulmonary vein ablation, roof line and mitral isthmus line ablation.
  
  
  CONCLUSIONS
  Satisfactory long term results are observed in atrial fibrillation patients with KCNA5 and NPPA mutations post circumferential pulmonary vein ablation.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Rong-feng
authors.initials: RF
authors.lastname: Zhang
authors.forename: Yun-long
authors.initials: YL
authors.lastname: Xia
authors.forename: Chu-chu
authors.initials: CC
authors.lastname: Wang
authors.forename: Lian-jun
authors.initials: LJ
authors.lastname: Gao
authors.forename: Xiao-meng
authors.initials: XM
authors.lastname: Yin
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.forename: Pei-xin
authors.initials: PX
authors.lastname: Cong
authors.forename: Ying-xue
authors.initials: YX
authors.lastname: Dong
authors.forename: Shu-long
authors.initials: SL
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Yan-zong
authors.initials: YZ
authors.lastname: Yang
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000235:genetics / Q000601:surgery*; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D017115:Catheter Ablation; D005500:Follow-Up Studies; D006801:Humans; D051666:Kv1.5 Potassium Channel / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016896:Treatment Outcome
chemical_list: C496981:KCNA5 protein, human; D051666:Kv1.5 Potassium Channel; C472955:NPPA protein, human; D009320:Atrial Natriuretic Factor