title: Self-eating limits EGFR-dependent tumor growth.
abstract: Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.
authors.affiliation: Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA.
authors.forename: Valeria R
authors.initials: VR
authors.lastname: Fantin
authors.forename: Robert T
authors.initials: RT
authors.lastname: Abraham
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001343:Autophagy; D000071186:Beclin-1; D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins; C512478:EGFR protein, human; D066246:ErbB Receptors