title: Patient outcome after complete surgery for retroperitoneal sarcoma.
abstract: BACKGROUND
  Aggressive surgery has been suggested for improving local tumor control in patients with retroperitoneal sarcoma (RS). This study aimed at investigating local disease-free and overall survival after complete surgery, in patients with RS.
  
  
  METHODS
  Retrospective data of patients submitted to complete surgery for RS were extracted from a prospectively-maintained database.
  
  
  RESULTS
  Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%). Patients presenting with recurrent (hazard ratio (HR)=5.57, p=0.002) and high-grade (HR 3.47, p=0.041) tumors were at higher risk of local recurrence. Microscopically-involved tumor resection margins (HR=3.47, p=0.04) and recurrent tumor at presentation (HR=2.49, p=0.008) were independent predictors of poor survival.
  
  
  CONCLUSIONS
  Patients presenting with primary RS had longer local disease-free survival and overall survival than those with recurrent tumor after complete surgery. Complete surgery remains the standard-of-care for patients with primary RS.
authors.affiliation: Via Giustiniani, 2, 35128 Padova, Italy. pasqualisandro@hotmail.com.
authors.forename: Carlo Riccardo
authors.initials: CR
authors.lastname: Rossi
authors.forename: Andrea
authors.initials: A
authors.lastname: Varotto
authors.forename: Sandro
authors.initials: S
authors.lastname: Pasquali
authors.forename: Luca Giovanni
authors.initials: LG
authors.lastname: Campana
authors.forename: Simone
authors.initials: S
authors.lastname: Mocellin
authors.forename: Antonio
authors.initials: A
authors.lastname: Sommariva
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Montesco
authors.forename: Marco
authors.initials: M
authors.lastname: Rastrelli
authors.forename: Antonella
authors.initials: A
authors.lastname: Vecchiato
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Pilati
authors.forename: Donato
authors.initials: D
authors.lastname: Nitti
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
keywords: Retroperitoneal sarcoma; disease-free survival; overall survival; soft tissue sarcoma