title: Short-term overfeeding increases circulating adiponectin independent of obesity status.
abstract: BACKGROUND
  Adiponectin is an adipose tissue derived hormone which strengthens insulin sensitivity. However, there is little data available regarding the influence of a positive energy challenge (PEC) on circulating adiponectin and the role of obesity status on this response.
  
  
  OBJECTIVE
  The purpose of this study was to investigate how circulating adiponectin will respond to a short-term PEC and whether or not this response will differ among normal-weight(NW), overweight(OW) and obese(OB).
  
  
  METHODS
  We examined adiponectin among 64 young men (19-29 yr) before and after a 7-day overfeeding (70% above normal energy requirements). The relationship between adiponectin and obesity related phenotypes including; weight, percent body fat (%BF), percent trunk fat (%TF), percent android fat (%AF), body mass index (BMI), total cholesterol, HDLc, LDLc, glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were analyzed before and after overfeeding.
  
  
  RESULTS
  Analysis of variance (ANOVA) and partial correlations were used to compute the effect of overfeeding on adiponectin and its association with adiposity measurements, respectively. Circulating Adiponectin levels significantly increased after the 7-day overfeeding in all three adiposity groups. Moreover, adiponectin at baseline was not significantly different among NW, OW and OB subjects defined by either %BF or BMI. Baseline adiponectin was negatively correlated with weight and BMI for the entire cohort and %TF, glucose, insulin and HOMA-IR in OB. However, after controlling for insulin resistance the correlation of adiponectin with weight, BMI and %TF were nullified.
  
  
  CONCLUSIONS
  Our study provides evidence that the protective response of adiponectin is preserved during a PEC regardless of adiposity. Baseline adiponectin level is not directly associated with obesity status and weight gain in response to short-term overfeeding. However, the significant increase of adiponectin in response to overfeeding indicates the physiological potential for adiponectin to attenuate insulin resistance during the development of obesity.
authors.affiliation: Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
authors.forename: Farrell
authors.initials: F
authors.lastname: Cahill
authors.forename: Peyvand
authors.initials: P
authors.lastname: Amini
authors.forename: Danny
authors.initials: D
authors.lastname: Wadden
authors.forename: Sammy
authors.initials: S
authors.lastname: Khalili
authors.forename: Edward
authors.initials: E
authors.lastname: Randell
authors.forename: Sudesh
authors.initials: S
authors.lastname: Vasdev
authors.forename: Wayne
authors.initials: W
authors.lastname: Gulliver
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D006801:Humans; D006963:Hyperphagia / Q000097:blood*; D050356:Lipid Metabolism; D008297:Male; D009765:Obesity / Q000097:blood*; D010641:Phenotype; D013997:Time Factors; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose
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