title: Secondary metabolites from the Chinese liverwort Cephaloziella kiaeri.
abstract: Sixteen new clerodane diterpenoids, cephaloziellins A-P (1-16), and two known analogues (17 and 18) were isolated from an EtOH extract of the Chinese liverwort Cephaloziella kiaeri. The structures of the new compounds were elucidated from extensive spectroscopic data (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of 5, 9, and 15 were confirmed by single-crystal X-ray diffraction analyses. The absolute configurations of all new compounds were established by comparing experimental and calculated electronic circular dichroism spectra.
authors.affiliation: Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Science, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Li
authors.forename: Rong-Xiu
authors.initials: RX
authors.lastname: Zhu
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Li
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Jiao-Zhen
authors.initials: JZ
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Ye
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D035926:Hepatophyta / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal