title: Triterpene glycosides from the leaves of Pittosporum angustifolium.
abstract: Phytochemical investigation of the leaves of Pittosporum angustifolium resulted in the isolation and structural elucidation of nine new triterpene saponins, named pittangretosides A-I (1-9), together with a known compound (10). Mainly by NMR and HRESIMS experiments, eight compounds were identified as A1-barrigenol glycosides (1-7, 10), whereas two compounds exhibited an unusual 17,22-seco-backbone of oleanolic acid (8, 9). All compounds were evaluated for their in vitro cytotoxicities against human urinary bladder carcinoma cells (5637). Only compounds with an angeloyl-residue at C-22 of the aglycone (1-4 and 10) showed antiproliferative effects with IC50 values of 4.1, 5.2, 2.1, 17.9, and 2.4 µM, respectively.
authors.affiliation: Institute of Pharmacy, Department of Pharmaceutical Biology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Bäcker
authors.forename: Kristina
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: Karsten
authors.initials: K
authors.lastname: Siems
authors.forename: Martina
authors.initials: M
authors.lastname: Wurster
authors.forename: Anja
authors.initials: A
authors.lastname: Bodtke
authors.forename: Chamseddin
authors.initials: C
authors.lastname: Chamseddin
authors.forename: Max
authors.initials: M
authors.lastname: Crüsemann
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; D009828:Oleanolic Acid