title: VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases.
abstract: The terminal step in the ubiquitin modification system relies on an E3 ubiquitin ligase to facilitate transfer of ubiquitin to a protein substrate. The substrate recognition and ubiquitin transfer activities of the E3 ligase may be mediated by a single polypeptide or may rely on separate subunits. The latter organization is particularly prevalent among members of largest class of E3 ligases, the RING family, although examples of this type of arrangement have also been reported among members of the smaller HECT family of E3 ligases. This review describes recent discoveries that reveal the surprising and distinctive ability of VprBP (DCAF1) to serve as a substrate recognition subunit for a member of both major classes of E3 ligase, the RING-type CRL4 ligase and the HECT-type EDD/UBR5 ligase. The cellular processes normally regulated by VprBP-associated E3 ligases, and their targeting and subversion by viral accessory proteins are also discussed. Taken together, these studies provide important insights and raise interesting new questions regarding the mechanisms that regulate or subvert VprBP function in the context of both the CRL4 and EDD/UBR5 E3 ligases.
authors.affiliation: Department of Cell Proliferation, United Center for Advanced Research and Translational Medicine, Graduate School of Medicine, Tohoku University, Sendai 900-8575, Japan. tnakagaw@med.tohoku.ac.jp.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Koushik
authors.initials: K
authors.lastname: Mondal
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Swanson
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D049109:Cell Proliferation; D004249:DNA Damage; D004261:DNA Replication; D005786:Gene Expression Regulation; D006801:Humans; D008745:Methylation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction / Q000235:genetics; D013379:Substrate Specificity; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D014764:Viral Proteins; D044767:Ubiquitin-Protein Ligases; C530533:DCAF1 protein, human; D017346:Protein Serine-Threonine Kinases; C571226:VprBP protein, mouse
references.citation: Mol Cell Biol. 2008 Sep;28(18):5621-33
references.pmid: 18606781
references.citation: Nucleic Acids Res. 2012 Aug;40(15):7332-46
references.pmid: 22570418
references.citation: PLoS Biol. 2010 Jul 13;8(7):e1000422
references.pmid: 20644714
references.citation: Mol Cell. 2007 Jun 22;26(6):775-80
references.pmid: 17588513
references.citation: Curr Opin Struct Biol. 2011 Apr;21(2):257-64
references.pmid: 21288713
references.citation: Curr Opin Microbiol. 2010 Aug;13(4):517-23
references.pmid: 20699190
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D84-90
references.pmid: 22086963
references.citation: Mol Cell. 2006 Sep 1;23(5):709-21
references.pmid: 16949367
references.citation: Mol Cell. 2012 Nov 30;48(4):572-86
references.pmid: 23063525
references.citation: Int J Oncol. 2012 Nov;41(5):1561-9
references.pmid: 22941386
references.citation: Curr Opin Virol. 2012 Dec;2(6):755-63
references.pmid: 23062609
references.citation: Cell. 2011 Nov 23;147(5):1024-39
references.pmid: 22118460
references.citation: Genes Dev. 2007 Sep 15;21(18):2288-99
references.pmid: 17761813
references.citation: J Virol. 2012 Jan;86(2):806-20
references.pmid: 22072767
references.citation: Genome Biol. 2011;12(4):220
references.pmid: 21554755
references.citation: J Virol. 1997 Jun;71(6):4842-6
references.pmid: 9151883
references.citation: J Virol. 1995 Nov;69(11):6705-11
references.pmid: 7474080
references.citation: Annu Rev Genet. 2011;45:167-202
references.pmid: 21854230
references.citation: J Biol Chem. 2010 Mar 12;285(11):8352-62
references.pmid: 20064936
references.citation: Biochem Biophys Res Commun. 2008 Jan 18;365(3):490-5
references.pmid: 17997981
references.citation: Biochemistry. 2011 Mar 1;50(8):1359-67
references.pmid: 21226479
references.citation: J Biol Chem. 1994 Jun 3;269(22):15577-82
references.pmid: 8195203
references.citation: Annu Rev Biochem. 2012;81:203-29
references.pmid: 22524316
references.citation: Biochim Biophys Acta. 2014 Jan;1843(1):61-74
references.pmid: 23545411
references.citation: J Med Virol. 2007 May;79(5):639-46
references.pmid: 17387751
references.citation: J Biol Chem. 2010 Nov 26;285(48):37333-41
references.pmid: 20870715
references.citation: Bioessays. 2006 Jun;28(6):617-28
references.pmid: 16700065
references.citation: FEBS Lett. 2012 Aug 31;586(18):2803-12
references.pmid: 22841721
references.citation: EMBO J. 2012 Feb 15;31(4):945-58
references.pmid: 22157821
references.citation: Nat Cell Biol. 2009 Apr;11(4):409-19
references.pmid: 19287380
references.citation: J Virol. 2005 Sep;79(17):10978-87
references.pmid: 16103149
references.citation: Oncogene. 2008 Jul 3;27(29):4056-64
references.pmid: 18332868
references.citation: Curr Opin Microbiol. 2010 Feb;13(1):41-6
references.pmid: 20036613
references.citation: PLoS Pathog. 2011 Dec;7(12):e1002425
references.pmid: 22174685
references.citation: J Infect Dis. 2001 Feb 1;183(3):417-24
references.pmid: 11133373
references.citation: Annu Rev Genet. 2007;41:237-80
references.pmid: 17630848
references.citation: Front Oncol. 2012 Apr 09;2:29
references.pmid: 22655267
references.citation: Cell. 1994 Mar 11;76(5):789-91
references.pmid: 7907279
references.citation: Nature. 2006 Oct 5;443(7111):590-3
references.pmid: 16964240
references.citation: J Biol Chem. 2013 Mar 8;288(10):7252-62
references.pmid: 23362280
references.citation: Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):563-8
references.pmid: 19008197
references.citation: J Biol Chem. 2013 Jun 28;288(26):19116-26
references.pmid: 23677995
references.citation: PLoS One. 2011 Mar 02;6(3):e17151
references.pmid: 21399697
references.citation: Gene. 2001 Jan 24;263(1-2):131-40
references.pmid: 11223251
references.citation: Cell Cycle. 2007 Dec 15;6(24):3070-7
references.pmid: 18073532
references.citation: Nat Cell Biol. 2006 Nov;8(11):1277-83
references.pmid: 17041588
references.citation: Annu Rev Biochem. 2009;78:399-434
references.pmid: 19489725
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11778-83
references.pmid: 17609381
references.citation: J Cell Sci. 2012 Feb 1;125(Pt 3):531-7
references.pmid: 22389392
references.citation: Dev Biol. 2007 Feb 15;302(2):438-47
references.pmid: 17069791
references.citation: Dev Biol. 2007 Nov 1;311(1):106-23
references.pmid: 17870065
references.citation: Mol Cell Biol. 2012 Feb;32(4):783-96
references.pmid: 22184063
references.citation: Curr Opin Cell Biol. 2010 Feb;22(1):96-103
references.pmid: 19963362
references.citation: Nat Rev Neurol. 2011 Jun 07;7(7):392-9
references.pmid: 21647202
references.citation: Nature. 2011 May 25;474(7353):654-7
references.pmid: 21613998
references.citation: Cell. 2008 Dec 26;135(7):1213-23
references.pmid: 19109893
references.citation: J Biol Chem. 2013 May 31;288(22):15474-80
references.pmid: 23612978
references.citation: Cell Cycle. 2007 Jan 15;6(2):182-8
references.pmid: 17314515
references.citation: Cell. 2010 Feb 19;140(4):477-90
references.pmid: 20178741
references.citation: Genes Dev. 2006 Nov 1;20(21):2949-54
references.pmid: 17079684
references.citation: Mol Cell. 2010 Oct 22;40(2):179-204
references.pmid: 20965415
references.citation: J Biol Chem. 2012 Apr 6;287(15):12550-8
references.pmid: 22362772
references.citation: Cell. 1997 Sep 5;90(5):871-82
references.pmid: 9298899
references.citation: PLoS One. 2012;7(1):e30939
references.pmid: 22292079
references.citation: Nat Rev Mol Cell Biol. 2004 Oct;5(10):792-804
references.pmid: 15459660
references.citation: Nat Struct Mol Biol. 2010 Jan;17(1):105-11
references.pmid: 19966799
references.citation: Nature. 2011 Jun 29;474(7353):658-61
references.pmid: 21720370
references.citation: Nature. 2011 Nov 06;480(7377):379-82
references.pmid: 22056990
references.citation: Biochem Biophys Res Commun. 2003 Jul 4;306(3):693-700
references.pmid: 12810074
references.citation: Cell Div. 2007 Feb 06;2:5
references.pmid: 17280619
references.citation: J Biol Chem. 2002 Jan 11;277(2):883-6
references.pmid: 11719502
references.citation: J Biol Chem. 2011 Dec 23;286(51):43596-43600
references.pmid: 22069334
references.citation: J Biol Chem. 2002 Mar 22;277(12):10394-9
references.pmid: 11782491
references.citation: Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2737-46
references.pmid: 22822215
references.citation: Br J Cancer. 2012 Jan 17;106(2):243-7
references.pmid: 22187039
references.citation: Mol Cell Biol. 2006 Jul;26(13):4806-17
references.pmid: 16782870
references.citation: J Biol Chem. 2011 Apr 29;286(17):14972-82
references.pmid: 21383020
references.citation: Nat Rev Mol Cell Biol. 2010 Oct;11(10):728-38
references.pmid: 20861881
references.citation: J Virol. 1995 Nov;69(11):6859-64
references.pmid: 7474100