title: Strategies to prevent reperfusion injury to the brain following intrapartum hypoxia-ischemia.
abstract: Hypoxia-ischemia is an infrequent event which may occur prior to or during delivery, following a period of decreased placental and/or fetal blood flow. Following recovery, a reperfusion phase and secondary energy failure may occur 6-48 h subsequent to the initial insult. Therapeutic hypothermia may be offered to infants at risk for evolving encephalopathy if identified within the 6 h therapeutic window, and should be instituted as early as possible for eligible infants. Additionally, the clinician must pay close attention to supportive measures such as avoidance of hyperthermia, as well as comprehensive management of clinical or electrographic seizures, blood pressure, blood glucoses, and carbon dioxide levels.
authors.affiliation: Department of Pediatrics, Division of Newborn Medicine, Weill Cornell Medical College, New York - Presbyterian Hospital, 525 East 68th Street, N-506, New York, NY 10065, USA. Electronic address: erk9007@med.cornell.edu.
authors.forename: Ericalyn
authors.initials: E
authors.lastname: Kasdorf
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Perlman
mesh_terms: D001921:Brain / Q000503:physiopathology; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
keywords: Cerebral hypoxia–ischemia; Hypothermia; Infant; Newborn; Reperfusion injury