title: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal carcinomatosis arising from colorectal cancer.
abstract: BACKGROUND
  Peritoneal carcinomatosis (PC) from colorectal cancer is associated with a poor prognosis. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) have improved survival compared to systemic chemotherapy. We evaluate the results of this treatment in our institution.
  
  
  METHODS
  Treatment consisted of complete CRS followed by HIPEC with oxaliplatin (460 mg/m(2) ) in 2 L/m(2) of D5W at 42°C during 30 min.
  
  
  RESULTS
  From 2004 to 2011, 40 patients with PC from colorectal cancer were included and 25 CRS + HIPEC were performed. Six patients had a negative second-look surgery and nine had unresectable disease. Median follow-up was 22.8 months. Overall 3- and 5-year survival rates for the cohort were 56% and 33%. The 3- and 5-year overall survival rates were 61% and 36% for HIPEC group, 82% and 67% for patients with negative second-look, and 22% and 0% for the unresectable group (P = 0.0087). 3-year disease-free survival for HIPEC group was 22%. Major complication and mortality rate for HIPEC group were 20% and 4%. Peritoneal carcinomatosis index (P = 0.0374) and lymph node status (P = 0.027) were prognostic indicators.
  
  
  CONCLUSIONS
  CRS + HIPEC with oxaliplatin for PC from colorectal cancer is an effective treatment with encouraging survival results.
authors.affiliation: Department of Surgery, Hôpital Maisonneuve-Rosemont, University of Montreal, Montréal, Québec, Canada.
authors.forename: Mai-Kim
authors.initials: MK
authors.lastname: Gervais
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubé
authors.forename: Yarrow
authors.initials: Y
authors.lastname: McConnell
authors.forename: Pierre
authors.initials: P
authors.lastname: Drolet
authors.forename: Andrew
authors.initials: A
authors.lastname: Mitchell
authors.forename: Lucas
authors.initials: L
authors.lastname: Sideris
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007274:Injections, Intraperitoneal; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: HIPEC; MMC; chemotherapy; colorectal carcinoma; oxaliplatin