title: [Lung transplantation in pulmonary fibrosis and other interstitial lung diseases].
abstract: OBJECTIVE
  Interstitial lung disease (ILD) is the second indication for lung transplantation (LT) after emphysema. The aim of this study is to review the results of LT for ILD in Hospital Vall d'Hebron (Barcelona, Spain).
  
  
  METHODS
  We retrospectively studied 150 patients, 87 (58%) men, mean age 48 (r: 20-67) years between August 1990 and January 2010. One hundred and four (69%) were single lung transplants (SLT) and 46 (31%) bilateral-lung transplants (BLT). The postoperative diagnoses were: 94 (63%) usual interstitial pneumonia, 23 (15%) nonspecific interstitial pneumonia, 11 (7%) unclassifiable interstitial pneumonia and 15% miscellaneous. We describe the functional results, complications and survival.
  
  
  RESULTS
  The actuarial survival was 87, 70 and 53% at one, 3 and 5 years respectively. The most frequent causes of death included early graft dysfunction and development of chronic rejection in the form of bronchiolitis obliterans (BOS). The mean postoperative increase in forced vital capacity and forced expiratory volume in the first second (FEV1) was similar in SLT and BLT. The best FEV1 was reached after 10 (r: 1-36) months. Sixteen percent of patients returned to work. At some point during the evolution, proven acute rejection was diagnosed histologically in 53 (35%) patients. The prevalence of BOS among survivors was 20% per year, 45% at 3 years and 63% at 5 years.
  
  
  CONCLUSIONS
  LT is the best treatment option currently available for ILD, in which medical treatment has failed.
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Berastegui
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Victor
authors.initials: V
authors.lastname: Monforte
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Bravo
authors.affiliation: Servei de Cirurgia Toràcica, Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Joan
authors.initials: J
authors.lastname: Sole
authors.affiliation: Servei de Malalties Infeccioses, Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Joan
authors.initials: J
authors.lastname: Gavalda
authors.affiliation: Servei de Cures Intensives, Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Tenório
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Villar
authors.affiliation: Servei d'Anestesiologia, Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Rochera
authors.affiliation: Servei de Cirurgia Toràcica, Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Mercè
authors.initials: M
authors.lastname: Canela
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Ferran
authors.initials: F
authors.lastname: Morell
authors.affiliation: Servei de Pneumologia, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital General Universitari Vall d'Hebron, Barcelona, España. Electronic address: aroman@vhebron.net.
authors.forename: Antonio
authors.initials: A
authors.lastname: Roman
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000401:mortality; D051799:Delayed Graft Function / Q000209:etiology / Q000401:mortality; D005260:Female; D005541:Forced Expiratory Volume; D006084:Graft Rejection / Q000209:etiology / Q000401:mortality; D006801:Humans; D007239:Infections / Q000453:epidemiology / Q000209:etiology; D053208:Kaplan-Meier Estimate; D017563:Lung Diseases, Interstitial / Q000601:surgery*; D016040:Lung Transplantation / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011658:Pulmonary Fibrosis / Q000601:surgery*; D012189:Retrospective Studies; D013030:Spain; D015996:Survival Rate; D014797:Vital Capacity; D055815:Young Adult
keywords: Enfermedad pulmonar intersticial; Fibrosis Pulmonar; Interstitial lung disease; Lung transplantation; Pulmonary fibrosis; Trasplante pulmonar