title: Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen.
abstract: Transgenic rats with low brain angiotensinogen, TGR(ASrAOGEN)680, expressing an antisense RNA against angiotensinogen in glial cells, provide an interesting tool to evaluate the role of brain angiotensins in different behavior responses. The present study was conducted to test the hypothesis that angiotensin-(1-7) [Ang-(1-7)] and serotonin can modulate anxiety and depression-related behaviors in the TGR(ASrAOGEN)680 rats. Therefore, the effect of acute intracerebroventricular administration of Ang-(1-7) and intraperitoneal administration of the selective serotonin reuptake inhibitor fluoxetine was evaluated in TGR(ASrAOGEN) rats subjected to the elevated plus maze (EPM) and forced swimming (FST) tests. Transgenic rats spent a lower percentage of time in the open arms of EPM and showed a significant increase in the immobility time in FST, indicating that a low angiotensinogen level in the brain leads to anxiety-like behavior accompanied by a depression-like state. Administration of both, Ang-(1-7) and fluoxetine reversed the anxiety- and depressive-like behavior of transgenic rats with low brain angiotensinogen, suggesting that this may be, at least in part, related to a decreased level of Ang-(1-7) and serotonin in the brain of these animals.
authors.affiliation: National Institute of Science and Technology-Nanobiofar, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Kangussu
authors.forename: Ana F
authors.initials: AF
authors.lastname: Almeida-Santos
authors.forename: Michael
authors.initials: M
authors.lastname: Bader
authors.forename: Natalia
authors.initials: N
authors.lastname: Alenina
authors.forename: Marco Antônio P
authors.initials: MA
authors.lastname: Fontes
authors.forename: Robson A S
authors.initials: RA
authors.lastname: Santos
authors.forename: Daniele C
authors.initials: DC
authors.lastname: Aguiar
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Campagnole-Santos
mesh_terms: D000803:Angiotensin I / Q000627:therapeutic use*; D000808:Angiotensinogen / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000235:genetics; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D005473:Fluoxetine / Q000627:therapeutic use; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D010446:Peptide Fragments / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D016372:RNA, Antisense / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D055647:Rats, Transgenic; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013550:Swimming / Q000523:psychology
chemical_list: D000803:Angiotensin I; D000808:Angiotensinogen; D005473:Fluoxetine; D010446:Peptide Fragments; D011619:Psychotropic Drugs; D016372:RNA, Antisense; D017367:Selective Serotonin Reuptake Inhibitors; C118790:angiotensin I (1-7)
keywords: Angiotensin-(1-7); Anxiety; Depression; Fluoxetine; Low brain angiotensinogen transgenic rats