title: African-Americans, Hispanic Americans, and non-Hispanic whites without GERD or reflux symptoms have equivalent 24-h pH esophageal acid exposure.
abstract: BACKGROUND
  Ambulatory esophageal pH monitoring is, currently, the recommended diagnostic exam for gastroesophageal reflux disease. Data are currently available for African-American (AA) and non-Hispanic white (nHw) volunteers among United States ethnic groups. The purpose of this study was to obtain normal values of 24-h esophageal pH by monitoring healthy adult Hispanic American (HA) volunteers and to compare these with values obtained from healthy AA and nHw volunteers to determine if ethnic variation exists in 24-h esophageal pH.
  
  
  METHODS
  24-h Dual esophageal pH monitoring was performed for healthy AA, HA, and nHw. Values for total number of reflux episodes, episodes longer than 5 min, total reflux time, and longest reflux episode in the proximal and/or distal esophagus were obtained for all groups. Differences between groups were considered significant if p<0.05.
  
  
  RESULTS
  One-hundred and thirty-six subjects volunteered and completed 24-h pH testing. Fifty-three were AA, 25 HA, and 58 nHw, with males accounting for 52, 47, and 47%, respectively, of each group. AA were older than nHw only and nHw had a lower body mass index than both AA and HA. Shorter study duration was observed for HA than for AA and nHw. No difference was observed between ethnic groups for any measured pH data in the proximal or distal esophagus.
  
  
  CONCLUSIONS
  No difference exists in values obtained during esophageal pH monitoring among healthy AA, HA, and nHw. This indicates that currently accepted normal values of ambulatory esophageal pH monitoring can be used for all major United States ethnic groups without compromising diagnostic accuracy.
authors.affiliation: Division of Gastroenterology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA, kenneth-vega@ouhsc.edu.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Vega
authors.forename: Tracy
authors.initials: T
authors.lastname: Langford
authors.forename: Carlos
authors.initials: C
authors.lastname: Palacio
authors.forename: Janet
authors.initials: J
authors.lastname: Watts
authors.forename: M Mazen
authors.initials: MM
authors.lastname: Jamal
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D050782:Esophageal pH Monitoring; D004947:Esophagus / Q000502:physiology; D005260:Female; D064368:Healthy Volunteers; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D044465:White People; D055815:Young Adult
references.citation: Gut. 2007 Jun;56(6):756-62
references.pmid: 17047097
references.citation: Dis Esophagus. 2010 Nov;23(8):609-12
references.pmid: 20545972
references.citation: Br J Cancer. 2009 Sep 1;101(5):855-9
references.pmid: 19672254
references.citation: Dig Dis Sci. 2010 Jun;55(6):1622-6
references.pmid: 19688596
references.citation: Neurogastroenterol Motil. 2006 Jun;18(6):425-32
references.pmid: 16700721
references.citation: Gut. 1987 Sep;28(9):1145-50
references.pmid: 3315881
references.citation: J Natl Med Assoc. 1994 Aug;86(8):620-3
references.pmid: 7932841
references.citation: J Clin Gastroenterol. 1989 Jun;11(3):260-70
references.pmid: 2666499
references.citation: J Natl Med Assoc. 1975 Mar;67(2):91-6
references.pmid: 1133873
references.citation: N Engl J Med. 2006 Jun 1;354(22):2340-8
references.pmid: 16738270
references.citation: Dig Dis Sci. 2012 Feb;57(2):419-23
references.pmid: 21909989
references.citation: Respir Physiol. 1978 Jun;33(3):367-93
references.pmid: 705072
references.citation: Aliment Pharmacol Ther. 2005 Nov 15;22(10):1005-10
references.pmid: 16268976
references.citation: Arch Intern Med. 1991 Mar;151(3):501-5
references.pmid: 2001132
references.citation: N Engl J Med. 1996 Aug 1;335(5):304-10
references.pmid: 8663870
references.citation: Am J Gastroenterol. 2005 Jun;100(6):1243-50
references.pmid: 15929752
references.citation: Am J Gastroenterol. 2008 Nov;103(11):2669-80
references.pmid: 19032462
references.citation: Dig Dis Sci. 1999 Nov;44(11):2290-4
references.pmid: 10573376
references.citation: Dig Dis Sci. 1992 Jun;37(6):849-56
references.pmid: 1587189
references.citation: Aliment Pharmacol Ther. 2008 Sep 1;28(5):655-9
references.pmid: 18616647
references.citation: J Natl Med Assoc. 1977 May;69(5):327-31
references.pmid: 864773
references.citation: World J Gastroenterol. 2009 Jun 21;15(23):2878-81
references.pmid: 19533809