title: Rubus coreanus Miquel inhibits acetylcholinesterase activity and prevents cognitive impairment in a mouse model of dementia.
abstract: To find acetylcholinesterase (AChE) inhibitors for the prevention of neurological disorders, such as Alzheimer's disease, ethanol extracts of promising traditional edible Korean plants were tested. Among them, Rubus coreanus Miquel extract exhibited the most significant AChE inhibitory activity. The effect of R. coreanus extract on trimethyltin-induced memory impairment in mice was investigated using Y-maze and passive avoidance tests. Our results showed that administration of R. coreanus extract significantly improved alternation behavior and step-through latency. In addition, R. coreanus extract was sequentially fractionated, and the purified constituent was determined to be 3,4,5-trihydroxybenzoic acid.
authors.affiliation: 1 Department of Food and Biotechnology, Korea University , Seoul, Republic of Korea.
authors.forename: Cho Rong
authors.initials: CR
authors.lastname: Kim
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Seung Sang
authors.initials: SS
authors.lastname: Oh
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Kwon
authors.forename: Na Young
authors.initials: NY
authors.lastname: Lee
authors.forename: Gwi Gun
authors.initials: GG
authors.lastname: Park
authors.forename: Youn-Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Heo
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Jun
authors.forename: Cheung-Seog
authors.initials: CS
authors.lastname: Park
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D003072:Cognition Disorders / Q000188:drug therapy / Q000201:enzymology / Q000517:prevention & control* / Q000523:psychology; D003704:Dementia / Q000188:drug therapy* / Q000201:enzymology / Q000523:psychology; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D018782:Maze Learning; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase
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