title: Cardiovascular effects of arsenic: clinical and epidemiological findings.
abstract: Several population studies relate exposure to high levels of arsenic with an increased incidence of ischemic heart disease and cardiovascular mortality. An association has been shown between exposure to high levels of arsenic and cardiovascular risk factors such as hypertension and diabetes mellitus, and vascular damage such as subclinical carotid atherosclerosis. The mechanisms underlying these phenomena are currently being studied and appear to indicate an alteration of vascular function. However, the effects of low levels of exposure to arsenic and their potential detrimental cardiovascular effect are less explored. The article provides an overview of the pathophysiologic mechanisms linking low-level arsenic exposure to the occurrence of cardiovascular disease and its complications, and some potential preventive strategies to implement.
authors.affiliation: CNR, Institute of Clinical Physiology, Via G. Moruzzi, 1, 56124, Pisa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Stea
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Bianchi
authors.forename: Liliana
authors.initials: L
authors.lastname: Cori
authors.forename: Rosa
authors.initials: R
authors.lastname: Sicari
mesh_terms: D001151:Arsenic / Q000378:metabolism / Q000633:toxicity*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D012307:Risk Factors
chemical_list: D001151:Arsenic
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