title: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.
abstract: OBJECTIVE
  Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH.
  
  
  METHODS
  The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case-control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region.
  
  
  RESULTS
  As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation.
  
  
  CONCLUSIONS
  The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.
authors.affiliation: From the University of Cincinnati, College of Medicine, OH (D.W., J.O., M.F.); Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.R.); Department of Neurology, Georgetown University Medical Center, Washington, DC (C.K.); John P. Hussman Institute for Human Genomics, University of Miami, FL (J.L.M., S.E.W.); Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (M.W.B., C.D.L.); Institute for Policy Research, University of Cincinnati, OH (E.W.R.); National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.W., J.N.R.); University of Miami, Miller School of Medicine, FL (S.K., R.I.S.); University of Texas Medical School-Houston, TX (N.R.G., R.M.); University of Southern California, Neurocritical Care and Stroke Division, Los Angeles, CA (G.S.); University of Maryland, Baltimore Veterans Administration Medical Center, MD (S.K.); University of Texas Health Science Center at San Antonio, TX (L.B., F.J., A.L.); Emory University, Grady Memorial Hospital, Atlanta, GA (M.F.); University of Illinois at Chicago Medical Center, IL (F.D.T.); Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX (C.E.H.); Columbia University, New York, NY (M.S.V.E.); University of Arizona, Tucson, AZ (B.C.); St. Luke's-Roosevelt Hospital Center, New York, NY (J.Y.C.); University of California San Francisco, Fresno, CA (T.W.); University of New Mexico, Albuquerque, NM (M.M.); Department of Anesthesiology, Duke University, Durham, NC (M.L.J.); University of California, Los Angeles, CA (L.K.A.); Department of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA (B.B.W.); and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (T.W.).
authors.forename: Daniel
authors.initials: D
authors.lastname: Woo
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Chelsea
authors.initials: C
authors.lastname: Kidwell
authors.forename: Jacob L
authors.initials: JL
authors.lastname: McCauley
authors.forename: Jennifer
authors.initials: J
authors.lastname: Osborne
authors.forename: Mark W
authors.initials: MW
authors.lastname: Brown
authors.forename: Sandra E
authors.initials: SE
authors.lastname: West
authors.forename: Eric W
authors.initials: EW
authors.lastname: Rademacher
authors.forename: Salina
authors.initials: S
authors.lastname: Waddy
authors.forename: Jamie N
authors.initials: JN
authors.lastname: Roberts
authors.forename: Sebastian
authors.initials: S
authors.lastname: Koch
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Gonzales
authors.forename: Gene
authors.initials: G
authors.lastname: Sung
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kittner
authors.forename: Lee
authors.initials: L
authors.lastname: Birnbaum
authors.forename: Michael
authors.initials: M
authors.lastname: Frankel
authors.forename: Fernando Daniel
authors.initials: FD
authors.lastname: Testai
authors.forename: Christiana E
authors.initials: CE
authors.lastname: Hall
authors.forename: Mitchell S V
authors.initials: MS
authors.lastname: Elkind
authors.forename: Matthew
authors.initials: M
authors.lastname: Flaherty
authors.forename: Bruce
authors.initials: B
authors.lastname: Coull
authors.forename: Ji Y
authors.initials: JY
authors.lastname: Chong
authors.forename: Tanya
authors.initials: T
authors.lastname: Warwick
authors.forename: Marc
authors.initials: M
authors.lastname: Malkoff
authors.forename: Michael L
authors.initials: ML
authors.lastname: James
authors.forename: Latisha K
authors.initials: LK
authors.lastname: Ali
authors.forename: Bradford B
authors.initials: BB
authors.lastname: Worrall
authors.forename: Floyd
authors.initials: F
authors.lastname: Jones
authors.forename: Tiffany
authors.initials: T
authors.lastname: Watson
authors.forename: Anne
authors.initials: A
authors.lastname: Leonard
authors.forename: Rebecca
authors.initials: R
authors.lastname: Martinez
authors.forename: Ralph I
authors.initials: RI
authors.lastname: Sacco
authors.forename: Carl D
authors.initials: CD
authors.lastname: Langefeld
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000208:ethnology / Q000628:therapy; D016208:Databases, Factual; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D044465:White People
keywords: cerebral hemorrhage; genetics; genomics; hypertension; minority groups; risk factors; stroke
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