title: Role of dongchongxiacao (Cordyceps) in prevention of contrast-induced nephropathy in patients with stable angina pectoris.
abstract: OBJECTIVE
  To study the preventative effects of Dongchongxiacao (Cordyceps) on contrast-induced nephropathy (CIN) in patients with stable angina pectoris (SAP).
  
  
  METHODS
  One-hundred and three SAP inpatients were divided randomly into two groups: basic treatment (n = 51) and Dongchongxiacao (Cordyceps) treatment (n = 52); corbrin capsules (3 g; t.d.s.) were used 3 days before angioplasty and 3 days after angioplasty). Serum creatinine (Scr) was assessed at the time of hospital admission and 1, 2, and 3 days after angioplasty. Values of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and interleukin (IL) 18 in the kidney were detected before angioplasty and 1 day after angioplasty in the patients of both groups. The prevalence of CIN between the two groups was then compared.
  
  
  RESULTS
  CIN occurred in 9 of 103 patients (8.74%). The prevalence of CIN in the Dongchongxiacao (Cordyceps) treatment group was lower than that of the basic treatment group (5.77% vs 11.76%) but the difference was not significant (P > 0.05). The post-procedure mean peak of Scr, post-procedure increase in Scr levels from baseline, and urine levels of KIM-1, NGAL and IL18 after the procedure in the Dongchongxiacao (Cordyceps) treatment group were significantly lower than those in the basic treatment group (P < 0.05).
  
  
  CONCLUSIONS
  Prophylactic treatment with Dongchongxiacao (Cordyceps) in SAP patients who undergo coronary angiography or coronary intervention could prevent contrast-induced renal impairment.
authors.affiliation: Department of Cardiology, Tianjin Nankai Hospital, Tianjin 300100, China. kai155@sohu.com
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine; D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D032661:Cordyceps / Q000737:chemistry*; D017023:Coronary Angiography / Q000009:adverse effects / Q000295:instrumentation; D003404:Creatinine / Q000097:blood; D005260:Female; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine; D008875:Middle Aged; D009036:Moths / Q000737:chemistry*; D028321:Plant Preparations / Q000008:administration & dosage*; D011518:Proto-Oncogene Proteins / Q000652:urine; D011877:Radionuclide Imaging; D011991:Receptors, Virus; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D003287:Contrast Media; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D028321:Plant Preparations; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D003404:Creatinine