title: Coupling biocatalysis with molecular imprinting in a biomimetic sensor.
abstract: Make it simple: A molecularly imprinted electropolymer was combined with an enzyme in a catalytic biomimetic sensor that enabled interference-free detection of the drug aminopyrine (AP) at submicromolar concentrations in the presence of ascorbic acid and uric acid within 15 s. The sensor functioned by the peroxide-dependent conversion of AP in a layer above a product-imprinted electropolymer on an indicator electrode.
authors.affiliation: Fraunhofer Institute for Biomedical Engineering, Am Mühlenberg 13, 14476 Potsdam (Germany); Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476 Potsdam (Germany).
authors.forename: Aysu
authors.initials: A
authors.lastname: Yarman
authors.forename: Frieder W
authors.initials: FW
authors.lastname: Scheller
mesh_terms: D055162:Biocatalysis; D032701:Biomimetics / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation*; D002384:Catalysis; D006801:Humans; D054802:Molecular Imprinting / Q000379:methods*
keywords: biomimetic sensors; electropolymers; enzymes; hierarchical structures; molecularly imprinted polymers