title: Reduction in bradykinin generation during leukocytapheresis using novel cellsorba(TM) CS-180S: Effects of changing the filling solution.
abstract: We evaluated the bradykinin generation level during leukocytapheresis (LCAP) using novel Cellsorba(TM) CS-180S, which has sodium pyrosulfite and sodium carbonate as a filling solution. Subjects of this study were 14 rheumatoid arthritis patients. Regardless of the type of anticoagulant used, bradykinin levels were lower with the novel CS-180S than with the conventional CS-180S (28.7 ± 53.3 vs. 8.0 ± 2.7 as the mean ± standard deviation). When anticoagulants other than nafamostat mesilate were used with the conventional CS-180S, bradykinin levels increased at the column outlet compared with the column inlet, and adverse effects of bradykinin were seen in several cases. In contrast, bradykinin levels remained low and no bradykinin-associated adverse events were observed with the novel CS-180S. We recommend using the novel column instead of the conventional column in the treatment of LCAP.
authors.affiliation: Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Yamada
authors.forename: Makio
authors.initials: M
authors.lastname: Kusaoi
authors.forename: Go
authors.initials: G
authors.lastname: Murayama
authors.forename: Misa
authors.initials: M
authors.lastname: Yasui
authors.forename: Ruka
authors.initials: R
authors.lastname: Hishinuma
authors.forename: Takuya
authors.initials: T
authors.lastname: Nemoto
authors.forename: Katsura
authors.initials: K
authors.lastname: Hohtatsu
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kageyama
authors.forename: Toshio
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Sekiya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kon
authors.forename: Michihiro
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kempe
authors.forename: Ken
authors.initials: K
authors.lastname: Yamaji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuda
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takasaki
mesh_terms: D001777:Blood Coagulation; D001920:Bradykinin / Q000009:adverse effects / Q000096:biosynthesis*; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D012996:Solutions
chemical_list: D012996:Solutions; D001920:Bradykinin
keywords: bradykinin generation; leukocytapheresis; novel column