title: Second primary tumors and myeloperoxidase expression in buccal mucosal squamous cell carcinoma.
abstract: OBJECTIVE
  The present study investigated the relationship between the expression of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC), and the risk of second primary tumors (SPTs).
  
  
  METHODS
  Immunohistochemistry was performed to examine the expression of MnSOD, GPx, catalase, and MPO in tissue microarray slides of 173 male patients with buccal mucosal SCC who had undergone potentially curative resections.
  
  
  RESULTS
  Forty-five (26.01%) patients developed SPTs. The prevalent subsites of SPTs were buccal mucosa (48.89%), tongue (13.33%), and lip (11.11%). High expression level of MPO was correlated with an increased risk of SPTs, even after adjustment for development of clinicopathologic parameters (high vs. low expression, adjusted hazard ratio = 3.89; 95% confidence interval, 1.33-11.41; P = .013).
  
  
  CONCLUSIONS
  SPTs are common in male buccal mucosal SCC patients. Higher MPO expression in buccal mucosal SCC is a risk factor for SPTs.
authors.affiliation: Resident Doctor, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Director, Pathology Department, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung, Taiwan.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Lai
authors.forename: Chien-Chou
authors.initials: CC
authors.lastname: Chen
authors.forename: Jang-Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Chia-Jung
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jyh-Seng
authors.initials: JS
authors.lastname: Wang
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Hou
authors.forename: Huei-Han
authors.initials: HH
authors.lastname: Liou
authors.forename: Hung-Chih
authors.initials: HC
authors.lastname: Chen
authors.forename: Ting-Ying
authors.initials: TY
authors.lastname: Fu
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Lee
authors.forename: Luo-Ping
authors.initials: LP
authors.lastname: Ger
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism*; D016016:Proportional Hazards Models; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D009195:Peroxidase