title: Role of sirtuins in stem cell differentiation.
abstract: Sirtuins play an essential role in the cellular response to environmental stress, promoting DNA repair, telomere stability, cell cycle arrest, cellular senescence, and apoptosis. Much attention has been given to the role of sirtuins in aging and cancer development; however, less is known about their role in stem cell regulation. This review focuses in this topic and discusses the possible implications in adult stem cell aging.
authors.affiliation: Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA-HUCA), Universidad de Oviedo, Oviedo, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: Rodriguez
authors.forename: A F
authors.initials: AF
authors.lastname: Fernandez
authors.forename: M F
authors.initials: MF
authors.lastname: Fraga
keywords: aging; development; sirtuins; stem cells
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