title: Isolation and structural determination of makinolide B from Streptomyces sp. MK-19.
abstract: A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100 µg/disk.
authors.affiliation: Graduate School of Agriculture, Shizuoka University.
authors.forename: Michitaka
authors.initials: M
authors.lastname: Hidaki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Naoto
authors.initials: N
authors.lastname: Ogawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Kodani
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D008958:Models, Molecular; D008968:Molecular Conformation; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C587918:makinolide B