title: Metallic stents for airway complications after lung transplantation: long-term follow-up.
abstract: OBJECTIVE
  Bronchial stenosis is still a significant source of morbidity and mortality following lung transplantation (LTX) and often mandating placement of a bronchial stent. It has been suggested that although self-expanding metal stents offer excellent early palliation, their long-term complication rates are unacceptably high, and hence, their usage in many transplantation centres has been nearly abandoned. The aim of the study was to assess short- and long-term complication rates and survival in LTX patients with bronchial stenosis treated with insertion of self-expanding metal stents.
  
  
  METHODS
  From January 1997 to March 2013, 435 patients underwent LTX (325 single-LTX and 110 bilateral LTX). Of 503 actual anastomoses at risk (derived by subtracting the number of anastomoses in 30 patients who died within 30 days of LTX), 60 airway complications (11.9%) in 47 patients required self-expanding metal stent insertion. We assessed the early results and long-term outcomes and survival compared with LTX patients in whom stents were not required.
  
  
  RESULTS
  The median follow-up period ranged from 1 to 132 (median 54) months. Immediate relief of symptoms was achieved in the vast majority of patients (95%). One-, three- and five-year survival in patients who required self-expanding metal stent placement were 77.7, 66.6 and 55.5%, respectively. The corresponding survival rates in LTX patients without stents were 69, 64.9 and 61.1% (P > 0.05).
  
  
  CONCLUSIONS
  Self-expanding metal stents are safe and effective tools in the management of airway complications post-LTX and provide immediate improvement in symptoms and pulmonary function tests in the vast majority of cases. The long-term complication rate is low, and mortality is similar to that in LTX patients who did not require stent insertion.
authors.affiliation: The Pulmonary Division, Rabin Medical Center, Petach Tikva, Israel.
authors.forename: Nader
authors.initials: N
authors.lastname: Abdel-Rahman
authors.forename: Mordechai R
authors.initials: MR
authors.lastname: Kramer
authors.forename: Milton
authors.initials: M
authors.lastname: Saute
authors.forename: Yael
authors.initials: Y
authors.lastname: Raviv
authors.forename: Oren
authors.initials: O
authors.lastname: Fruchter
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000009:adverse effects* / Q000401:mortality*; D008670:Metals / Q000009:adverse effects / Q000627:therapeutic use; D015607:Stents / Q000009:adverse effects*
chemical_list: D008670:Metals
keywords: Airway stenosis; Lung transplantation; Metallic stent