title: Pericardial synovial sarcoma: a case report and review of the literature.
abstract: Primary pericardial synovial sarcoma is a rare disease. We herein report a case of synovial sarcoma that originated in the epicardium. A 13-year-old male visited our hospital with a fever and chest pain. Copious pericardial effusion and a large intrapericardial tumor were detected. An open-chest tumor resection was performed. A solid nodular tumor was observed in the pericardial cavity. The tumor was a polypoid mass that was pedunculated and grew from the inner surface of the pericardium near the origin of the SVC and ascending aorta. Histologically, the tumor cells were uniformly spindle shaped, with an ovoid or oval nucleus, and formed solid, compact sheets and fascicles. A storiform pattern was also observed. Based on the histopathological and immunohistochemical findings, and the fluorescence in situ hybridization detection of rearrangement of the SYT gene, a monophasic synovial sarcoma was diagnosed. We discuss the diagnosis and treatment of this case and review the pertinent literature.
authors.affiliation: Department of Thoracic Surgery, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96 Owada-shinden, Yachiyo, Chiba, 276-8524, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yoshino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sekine
authors.forename: Eitetsu
authors.initials: E
authors.lastname: Koh
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kume
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saito
authors.forename: Sho
authors.initials: S
authors.lastname: Kimura
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hamada
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000008:administration & dosage; D015321:Gene Rearrangement; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D010496:Pericardium; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C093961:SS18 protein, human; D004317:Doxorubicin; D007069:Ifosfamide
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