title: The ratio of second to fourth digit length (2D:4D) and coronary artery disease in a Han Chinese population.
abstract: BACKGROUND
  The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.
  
  
  METHODS
  This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.
  
  
  RESULTS
  There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.
  
  
  CONCLUSIONS
  The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.
authors.affiliation: 1. Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xing-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Ding-You
authors.initials: DY
authors.lastname: Yang
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Chai
authors.forename: Ming-Lei
authors.initials: ML
authors.lastname: Jin
authors.forename: Xing-Chun
authors.initials: XC
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Zhao
mesh_terms: D000886:Anthropometry; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005385:Fingers / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D012737:Sex Factors
keywords: 2D:4D; Chinese; coronary angiography; coronary artery disease; diagnosis.; finger length ratio
references.citation: BJU Int. 2012 Jan;109(2):266-71
references.pmid: 21592297
references.citation: Evol Hum Behav. 2000 Sep 1;21(5):333-345
references.pmid: 11053694
references.citation: PLoS One. 2013;8(3):e58382
references.pmid: 23554888
references.citation: Clin Endocrinol (Oxf). 2003 Dec;59(6):749-55
references.pmid: 14974917
references.citation: Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16289-94
references.pmid: 21896736
references.citation: Maturitas. 2010 Sep;67(1):15-9
references.pmid: 20447781
references.citation: Med Hypotheses. 2010 Dec;75(6):671-3
references.pmid: 20810222
references.citation: Early Hum Dev. 2013 May;89(5):327-9
references.pmid: 23218867
references.citation: Lancet. 1973 Mar 17;1(7803):611
references.pmid: 4120679
references.citation: Asian J Androl. 2004 Sep;6(3):211-5
references.pmid: 15273869
references.citation: Endocrinol Metab Clin North Am. 2007 Jun;36(2):365-77
references.pmid: 17543724
references.citation: Int J Obes (Lond). 2006 Apr;30(4):711-4
references.pmid: 16261185
references.citation: J Lab Clin Med. 1993 Oct;122(4):412-20
references.pmid: 8228555
references.citation: Arch Sex Behav. 2007 Apr;36(2):223-33
references.pmid: 17373585
references.citation: Gend Med. 2010 Dec;7(6):628-36
references.pmid: 21195362
references.citation: Med Hypotheses. 2000 May;54(5):855-7
references.pmid: 10859702
references.citation: Soc Neurosci. 2009;4(1):49-59
references.pmid: 18633837
references.citation: Clin Endocrinol (Oxf). 2011 Aug;75(2):177-83
references.pmid: 21521286
references.citation: Arch Esp Urol. 2012 Nov;65(9):816-21
references.pmid: 23154605
references.citation: Am J Hum Biol. 2013 Jan-Feb;25(1):101-6
references.pmid: 23132707
references.citation: Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):695-701
references.pmid: 9108782
references.citation: Am J Phys Anthropol. 1975 Nov;43(3):327-32
references.pmid: 1211429
references.citation: Int J Impot Res. 2007 Mar-Apr;19(2):176-82
references.pmid: 16943795
references.citation: Am J Phys Anthropol. 2012 Oct;149(2):266-71
references.pmid: 22886721
references.citation: Hum Reprod. 1998 Nov;13(11):3000-4
references.pmid: 9853845
references.citation: Early Hum Dev. 2004 Nov;80(2):161-8
references.pmid: 15500996
references.citation: Hum Reprod. 2003 May;18(5):976-9
references.pmid: 12721171
references.citation: Lancet. 1976 Feb 7;1(7954):313-4
references.pmid: 55633
references.citation: Klin Wochenschr. 1991 Sep 16;69(14):664-8
references.pmid: 1836242
references.citation: Percept Mot Skills. 2002 Feb;94(1):171-81
references.pmid: 11883557
references.citation: Acta Biochim Pol. 2011;58(3):385-9
references.pmid: 21927720
references.citation: Arch Neurol. 1985 May;42(5):428-59
references.pmid: 3994562
references.citation: Circulation. 2011 Feb 1;123(4):e18-e209
references.pmid: 21160056
references.citation: Evol Hum Behav. 2000 May 1;21(3):163-183
references.pmid: 10828555
references.citation: Am Heart J. 1986 Feb;111(2):383-90
references.pmid: 3946178
references.citation: N Engl J Med. 1977 Jan 13;296(2):67-70
references.pmid: 830309
references.citation: Atherosclerosis. 2010 Mar;209(1):195-6
references.pmid: 19729164
references.citation: Zhonghua Nan Ke Xue. 2012 Oct;18(10):881-5
references.pmid: 23297494