title: Phytochemical analysis and anti-inflammatory potential of Hyphaene thebaica L. fruit.
abstract: Metabolite profiling and biological activity are reported from organic and aqueous extracts of the fruit from the desert palm Hyphaene thebaica. Phenolics and oxylipids profiles were determined using UPLC-PDA-TOF (ultra performance-photodiode array-time of flight) high-resolution mass spectrometry in order to obtain the molecular formula and exact mass Under optimized conditions, 17 compounds were simultaneously identified and quantified including 2 cinnamic acid derivatives, 5 flavonoids, 6 fatty acids, 2 sphingolipids, a lignan, and a stilbene. Sugars composition in the fruit was characterized and quantified by (1) H-NMR (nuclear magnetic resonance) with sucrose detected as the major component in fruit at a level of 219 mg/g. Fruit organic extracts anti-inflammatory potential was assessed in vitro by cyclooxygenase-1 enzyme inhibition.
authors.affiliation: Pharmacognosy Dept., Faculty of Pharmacy, Cairo Univ., Cairo 11562, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Farag
authors.affiliation: Dept. of Biochemistry, Texas Tech Univ., Lubbock, TX 79409, U.S.A.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000893:Anti-Inflammatory Agents / Q000032:analysis / Q000494:pharmacology*; D028023:Arecaceae / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D064209:Phytochemicals / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010636:Phenols; D064209:Phytochemicals; D010936:Plant Extracts
keywords: Hyphaene thebaica L; NMR; UPLC/MS; anti-inflammatory activity; phenolics