title: Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a small-volume, home-based exercise program.
abstract: OBJECTIVE
  Our objective was to evaluate the effects of small-volume, home-based exercise combined with slight caloric restriction on the inflammatory markers C-reactive protein and adiponectin.
  
  
  METHODS
  In total, 54 women were randomly assigned to one of two groups for exercise intervention: the control or home-based exercise groups. Weight, waist and hip circumferences, and inflammatory markers were measured at baseline and after 6 and 12 months. Women allocated to the home-based exercise group received a booklet explaining the physical exercises to be practiced at home at least 3 times per week, 40 minutes per session, at low-to-moderate intensity. All participants received dietary counseling aimed at reducing caloric intake by 100-300 calories per day, with a normal distribution of macro-nutrients (26-28% of energy as fat). Clinicaltrials.gov: NCT01206413 RESULTS: The home-based exercise group showed a significantly greater reduction in weight and body mass index at six months, but no difference between groups was observed thereafter. With regard to the inflammatory markers, a greater but non-statistically significant reduction was found for C-reactive protein in the home-based exercise group at six months; however, this difference disappeared after adjusting for weight change. No differences in adiponectin were found at the 6- or 12-month follow-up.
  
  
  CONCLUSIONS
  Small-volume, home-based exercise did not promote changes in inflammatory markers independent of weight change.
authors.affiliation: Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro (UERJ), Rio de JaneiroRJ, Brazil.
authors.forename: Mauro Felippe Felix
authors.initials: MF
authors.lastname: Mediano
authors.forename: Fabiana Alves
authors.initials: FA
authors.lastname: Neves
authors.forename: Alessandra Cordeiro de Souza Rodrigues
authors.initials: AC
authors.lastname: Cunha
authors.forename: Erica Patricia Garcia de
authors.initials: EP
authors.lastname: Souza
authors.forename: Anibal Sanchez
authors.initials: AS
authors.lastname: Moura
authors.forename: Rosely
authors.initials: R
authors.lastname: Sichieri
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D002097:C-Reactive Protein / Q000032:analysis*; D031204:Caloric Restriction; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood; D008875:Middle Aged; D012016:Reference Values; D013997:Time Factors; D055105:Waist Circumference / Q000502:physiology; D015431:Weight Loss; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D002097:C-Reactive Protein
references.citation: Circulation. 2012 Mar 6;125(9):1157-70
references.pmid: 22392863
references.citation: Metabolism. 2006 Oct;55(10):1375-81
references.pmid: 16979409
references.citation: Circ J. 2004 Nov;68(11):975-81
references.pmid: 15502375
references.citation: Sports Med. 2009;39(5):355-75
references.pmid: 19402741
references.citation: JAMA. 2003 Apr 9;289(14):1799-804
references.pmid: 12684358
references.citation: Eur J Appl Physiol. 2005 Aug;94(5-6):520-6
references.pmid: 15942768
references.citation: Metabolism. 2006 Nov;55(11):1500-7
references.pmid: 17046553
references.citation: Endocr J. 2006 Apr;53(2):189-95
references.pmid: 16618976
references.citation: J Pain Symptom Manage. 2013 May;45(5):811-21
references.pmid: 23017624
references.citation: Arch Intern Med. 2007 Jan 8;167(1):31-9
references.pmid: 17210875
references.citation: Diabetes Res Clin Pract. 2004 Feb;63(2):135-42
references.pmid: 14739054
references.citation: Dig Dis Sci. 2009 Sep;54(9):1847-56
references.pmid: 19052866
references.citation: J Nutr. 2008 Dec;138(12):2293-6
references.pmid: 19022947
references.citation: Med Sci Sports Exerc. 2004 Sep;36(9):1632-6
references.pmid: 15354048
references.citation: PLoS One. 2012;7(7):e41199
references.pmid: 22815970
references.citation: Metabolism. 2008 Apr;57(4):577-83
references.pmid: 18328363
references.citation: Prev Med. 2007 Jan;44(1):3-11
references.pmid: 17064760
references.citation: Clin Chim Acta. 2010 Jun 3;411(11-12):785-93
references.pmid: 20188719
references.citation: N Engl J Med. 2008 Nov 20;359(21):2195-207
references.pmid: 18997196
references.citation: Med Sci Sports Exerc. 2009 Feb;41(2):459-71
references.pmid: 19127177
references.citation: Am J Prev Med. 2006 Dec;31(6):484-91
references.pmid: 17169709
references.citation: Am J Clin Nutr. 2010 Jan;91(1):106-14
references.pmid: 19889820
references.citation: Diabetologia. 2008 Jan;51(1):39-46
references.pmid: 17972060
references.citation: J Leukoc Biol. 2005 Oct;78(4):819-35
references.pmid: 16033812
references.citation: Ann Epidemiol. 2003 Nov;13(10):674-82
references.pmid: 14599731
references.citation: Med Sci Sports Exerc. 2010 Apr;42(4):708-16
references.pmid: 19952828
references.citation: Eur J Appl Physiol. 2012 Apr;112(4):1207-14
references.pmid: 21769734
references.citation: Metabolism. 2005 Apr;54(4):533-41
references.pmid: 15798963
references.citation: Med Sci Sports Exerc. 2011 Jul;43(7):1334-59
references.pmid: 21694556
references.citation: Lancet. 2001 Mar 10;357(9258):763-7
references.pmid: 11253971
references.citation: Am J Clin Nutr. 2009 Feb;89(2):477-84
references.pmid: 19088151
references.citation: Psychosom Med. 1995 Jul-Aug;57(4):331-5
references.pmid: 7480562
references.citation: CMAJ. 2005 Apr 26;172(9):1199-209
references.pmid: 15851714
references.citation: PLoS One. 2012;7(9):e45693
references.pmid: 23029185
references.citation: Prev Med. 2005 Apr;40(4):432-7
references.pmid: 15530595
references.citation: Br J Sports Med. 2009 Jan;43(1):3-4
references.pmid: 18971243
references.citation: Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2148-65
references.pmid: 22447947
references.citation: Br J Nutr. 2011 Dec;106 Suppl 3:S5-78
references.pmid: 22133051
references.citation: Arch Intern Med. 2002 Jun 10;162(11):1286-92
references.pmid: 12038947
references.citation: Obes Rev. 2013 Mar;14(3):232-44
references.pmid: 23171381
references.citation: Diabetes Res Clin Pract. 2005 Jul;69(1):29-35
references.pmid: 15955385
references.citation: Nat Rev Immunol. 2011 Feb;11(2):85-97
references.pmid: 21252989
references.citation: Obesity (Silver Spring). 2011 Jun;19(6):1131-6
references.pmid: 21183937
references.citation: Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):608-17
references.pmid: 19695853
references.citation: Circulation. 2003 Jan 28;107(3):499-511
references.pmid: 12551878
references.citation: Prev Med. 2010 Sep-Oct;51(3-4):247-52
references.pmid: 20654643
references.citation: Lipids Health Dis. 2005 Nov 02;4:27
references.pmid: 16262911
references.citation: Obes Rev. 2000 Oct;1(2):95-111
references.pmid: 12119991
references.citation: J Am Coll Cardiol. 2005 May 17;45(10):1563-9
references.pmid: 15893167
references.citation: Med Sci Sports Exerc. 2009 Aug;41(8):1533-9
references.pmid: 19568208
references.citation: J Atheroscler Thromb. 2010 Nov 27;17(11):1160-6
references.pmid: 20805637
references.citation: Metabolism. 2011 Sep;60(9):1244-52
references.pmid: 21377179
references.citation: Med Sci Sports Exerc. 2010 Feb;42(2):304-13
references.pmid: 20083961
references.citation: Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E824-31
references.pmid: 20086201
references.citation: Diabetes Care. 2004 Feb;27(2):629-30
references.pmid: 14747265
references.citation: Life Sci. 2007 Jan 9;80(5):454-9
references.pmid: 17070556
references.citation: Obesity (Silver Spring). 2008 Feb;16(2):241-56
references.pmid: 18239630
references.citation: Mediators Inflamm. 2010;2010:
references.pmid: 20706689
references.citation: Scand J Med Sci Sports. 2008 Dec;18(6):736-41
references.pmid: 18248547
references.citation: Clinics (Sao Paulo). 2011;66(4):535-41
references.pmid: 21655743