title: Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma.
abstract: BACKGROUND
  Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.
  
  
  METHODS
  A 55-year-old male patient presented with an asymptomatic mass of the upper lip that had noticed 8 years previously. The mass was clinically suspected to be a benign salivary gland tumor based on palpation and magnetic resonance imaging findings. A needle biopsy was then carried out, and the pathological diagnosis was pleomorphic adenoma. The tumor was removed under general anesthesia. Histopathological examination revealed well-demarcated tumor tissues showing typical histologic features of pleomorphic adenoma. However, SCC tissue with several mitotic figures was found in the central area of the tumor tissue. The tumor was finally diagnosed as CXPA. There was no evidence of recurrence or metastasis 6 years postoperatively.
  
  
  CONCLUSIONS
  This is the first report of CXPA of the upper lip with an unusual malignant component of SCC.
authors.affiliation: Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. skawano@dent.kyushu-u.ac.jp.
authors.forename: Eiji
authors.initials: E
authors.lastname: Mitate
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kawano
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kiyoshima
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawazu
authors.forename: Toru
authors.initials: T
authors.lastname: Chikui
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Goto
authors.forename: Ryota
authors.initials: R
authors.lastname: Matsubara
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008048:Lip Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011379:Prognosis
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