title: The clinical implication of SS18-SSX fusion gene in synovial sarcoma.
abstract: BACKGROUND
  The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China.
  
  
  METHODS
  We collected and analysed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasion.
  
  
  RESULTS
  Overall survival was significantly better among SS18-SSX2 cases (P=0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells.
  
  
  CONCLUSIONS
  SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China.
authors.forename: T
authors.initials: T
authors.lastname: Ren
authors.forename: Q
authors.initials: Q
authors.lastname: Lu
authors.forename: W
authors.initials: W
authors.lastname: Guo
authors.forename: Z
authors.initials: Z
authors.lastname: Lou
authors.forename: X
authors.initials: X
authors.lastname: Peng
authors.forename: G
authors.initials: G
authors.lastname: Jiao
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D048708:Cell Growth Processes / Q000235:genetics; D002648:Child; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D041681:NIH 3T3 Cells; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016019:Survival Analysis; D014162:Transfection; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C093961:SS18 protein, human; C116512:SYT-SSX fusion protein; C093962:synovial sarcoma X breakpoint proteins
references.citation: Eur J Cancer Prev. 2008 Oct;17(5):392-8
references.pmid: 18714179
references.citation: Oncogene. 2001 Sep 10;20(40):5755-62
references.pmid: 11607825
references.citation: Genes Chromosomes Cancer. 2001 Aug;31(4):362-72
references.pmid: 11433527
references.citation: Cancer. 1999 Jun 15;85(12):2596-607
references.pmid: 10375108
references.citation: Mod Pathol. 2000 May;13(5):482-8
references.pmid: 10824918
references.citation: J Clin Oncol. 2001 Jan 15;19(2):525-34
references.pmid: 11208847
references.citation: Am J Surg Pathol. 1981 Mar;5(2):137-51
references.pmid: 6261596
references.citation: Oncol Rep. 2008 Feb;19(2):467-76
references.pmid: 18202796
references.citation: Hum Pathol. 2001 Jan;32(1):105-12
references.pmid: 11172303
references.citation: Cancer Res. 1999 Jul 1;59(13):3180-4
references.pmid: 10397263
references.citation: Int J Oncol. 2010 Apr;36(4):823-31
references.pmid: 20198325
references.citation: Br J Cancer. 2001 Nov 16;85(10):1535-9
references.pmid: 11720441
references.citation: Curr Probl Surg. 1996 Oct;33(10):817-72
references.pmid: 8885853
references.citation: AJR Am J Roentgenol. 1995 Jan;164(1):129-34
references.pmid: 7998525
references.citation: Cancer Res. 2002 Jan 1;62(1):135-40
references.pmid: 11782370
references.citation: Am J Surg Pathol. 1999 Mar;23(3):268-75
references.pmid: 10078916
references.citation: J Clin Oncol. 1997 Jan;15(1):350-62
references.pmid: 8996162
references.citation: Cancer. 1987 May 15;59(10):1810-4
references.pmid: 3828949
references.citation: Radiother Oncol. 1994 Oct;33(1):23-30
references.pmid: 7878206
references.citation: Genes Chromosomes Cancer. 2001 Jan;30(1):1-14
references.pmid: 11107170
references.citation: N Engl J Med. 1998 Jan 15;338(3):153-60
references.pmid: 9428816
references.citation: J Clin Oncol. 2004 Oct 15;22(20):4040-50
references.pmid: 15364967
references.citation: Diagn Mol Pathol. 1995 Sep;4(3):162-73
references.pmid: 7493135
references.citation: Cancer Detect Prev. 2004;28(4):294-301
references.pmid: 15350633
references.citation: J Clin Oncol. 2000 Nov 15;18(22):3794-803
references.pmid: 11078492
references.citation: J Clin Oncol. 2000 May;18(10):2087-94
references.pmid: 10811674
references.citation: Cancer Sci. 2009 Jun;100(6):1018-25
references.pmid: 19385976
references.citation: Am J Clin Pathol. 1999 Jul;112(1):43-9
references.pmid: 10396284
references.citation: Pediatr Blood Cancer. 2006 Jan;46(1):11-7
references.pmid: 16292743