title: [The therapeutic effect of antireflux medicine combined with positive airways pressure on obstructive sleep apnea hypopnea syndrome with gastroesophageal reflux].
abstract: OBJECTIVE
  To investigate the therapeutic effect of nasal continuous positive airways pressure (nCPAP) combined with antireflux medicine on obstructive sleep apnea hypopnea syndrome (OSAHS) with gastroesophageal reflux (GER).
  
  
  METHODS
  Sixty patients with moderate to severe OSAHS with GER were simultaneously received PSG and esophageal pH monitoring and randomly divided into control group and treatment group with each group 30 patients. The control group were simply received nCPAP for every night. The treatment group were received the same treatment and combined antireflux medicine, with esomeprazole 40 mg/d and mosapride citrate 5 mg, 3 times a day,oral. Both the groups symptomatic status of OSAHS and GER were observed on the third day and the 14th day during therapy, and then the same tests above were repeated on the 14th day.
  
  
  RESULTS
  Compared with the control group, the symptomatic improvement rate of OSAHS on the third day and 14th day during therapy,the symptomatic improvement rate of GER on the third day during therapy were increased with statistical significance in the treatment group (P<0.05), however, the difference of symptomatic improvement rate of GER between the two groups on the 14th day during therapy did not have statistical significance (P>0.05). Compared with those of the control group on the 14th therapeutic night, AHI, LSaO2, the percentage of time with pH<4, the longest reflux duration,reflux episodes and DeMeester scoring did not have statistical significance in the treatment group (P>0.05).
  
  
  CONCLUSIONS
  nCPAP is the most effective method for patients suffering OSAHS associated with GER, but nCPAP used in conjunction with anti-reflux drugs do not improve efficacy.
authors.affiliation: Department of Otorhinolaryngology, Clinical Medicine College of Southeast University, Jiangyin, 214400, China. chjx0314@126.com
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Chen
authors.forename: Youqin
authors.initials: Y
authors.lastname: Ai
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000628:therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy*
chemical_list: D005765:Gastrointestinal Agents