title: Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses.
abstract: BACKGROUND
  Salivary duct carcinoma with rhabdoid features is extremely rare.
  
  
  METHODS
  We report 2 cases of salivary duct carcinoma with rhabdoid features treated at our institution.
  
  
  RESULTS
  Case 1 was a 44-year-old Japanese man who had swelling in the left parotid region. This tumor consisted of residual pleomorphic adenoma and widely invasive carcinoma, which showed a diffuse growth pattern by atypical rhabdoid cells. Case 2 was a 66-year-old Japanese man who had swelling of the right cervical region. This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells. Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein-15 (GCDFP), and androgen receptor (AR). Case 1 was also positive for Her-2 and p53.
  
  
  CONCLUSIONS
  Both patients were diagnosed with carcinoma ex pleomorphic adenoma and their carcinomatous components were composed of salivary duct carcinoma with rhabdoid features, which is a highly aggressive tumor, similar to salivary duct carcinoma.
authors.affiliation: Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Kimihide
authors.initials: K
authors.lastname: Kusafuka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Onitsuka
authors.forename: Koji
authors.initials: K
authors.lastname: Muramatsu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miki
authors.forename: Chika
authors.initials: C
authors.lastname: Murai
authors.forename: Toshihito
authors.initials: T
authors.lastname: Suda
authors.forename: Tomohito
authors.initials: T
authors.lastname: Fuke
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kamijo
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Iida
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D018987:Salivary Ducts; D013365:Submandibular Gland Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure
keywords: carcinoma ex pleomorphic adenoma; immunohistochemistry; rhabdoid cells; salivary duct carcinoma; ultrastructure
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