title: Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques.
abstract: Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.
authors.affiliation: Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ, Rijswijk, The Netherlands, groot@bprc.nl.
authors.forename: Natasja G
authors.initials: NG
authors.lastname: de Groot
authors.forename: Corrine M C
authors.initials: CM
authors.lastname: Heijmans
authors.forename: Arnoud H
authors.initials: AH
authors.lastname: de Ru
authors.forename: Chopie
authors.initials: C
authors.lastname: Hassan
authors.forename: Nel
authors.initials: N
authors.lastname: Otting
authors.forename: Gaby G M
authors.initials: GG
authors.lastname: Doxiadis
authors.forename: Frits
authors.initials: F
authors.lastname: Koning
authors.forename: Peter A
authors.initials: PA
authors.lastname: van Veelen
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Bontrop
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics*; D000818:Animals; D044466:Asian People; D005802:Genes, MHC Class II / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007194:India; D008253:Macaca mulatta / Q000235:genetics* / Q000276:immunology; D010455:Peptides / Q000235:genetics*
chemical_list: D010455:Peptides
references.citation: Immunogenetics. 2010 Jul;62(7):451-64
references.pmid: 20480161
references.citation: Mol Biol Evol. 2007 Jan;24(1):26-53
references.pmid: 17047029
references.citation: Immunogenetics. 2013 May;65(5):371-86
references.pmid: 23417323
references.citation: Immunogenetics. 2013 Aug;65(8):569-84
references.pmid: 23715823
references.citation: Genome Res. 2004 Jun;14(6):1188-90
references.pmid: 15173120
references.citation: Immunogenetics. 2012 Oct;64(10):755-65
references.pmid: 22772814
references.citation: Science. 2008 Jul 25;321(5888):530-2
references.pmid: 18653883
references.citation: J Virol. 2007 Jan;81(1):349-61
references.pmid: 17035320
references.citation: Science. 1996 Apr 5;272(5258):67-74
references.pmid: 8600539
references.citation: Immunogenetics. 2012 Aug;64(8):615-31
references.pmid: 22526602
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1626-31
references.pmid: 15665097
references.citation: Genome Res. 2004 Aug;14(8):1501-15
references.pmid: 15289473
references.citation: Nat Med. 2009 Nov;15(11):1322-6
references.pmid: 19820716
references.citation: Nature. 1991 May 23;351(6324):290-6
references.pmid: 1709722
references.citation: Immunogenetics. 2010 Dec;62(11-12):773-80
references.pmid: 20882385
references.citation: Mol Cell Proteomics. 2013 Jul;12(7):1829-43
references.pmid: 23481700
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15175-80
references.pmid: 20696916
references.citation: Nat Med. 2008 Jun;14(6):617-21
references.pmid: 18535579
references.citation: Immunogenetics. 2004 Mar;55(12):797-810
references.pmid: 14963618