title: Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger.
abstract: Chemical compositions of ginger oil as well as its antioxidant, anti-inflammatory and antinociceptive potential were evaluated in the present study. The main constituents as detected by GC/MS analysis was alpha-zingiberene which constituted 31% of the total area, ar-curcumene (15.4%) and a -sesquiphellandrene (14.02%). Ginger oil scavenged superoxide, DPPH, hydroxyl radicals and inhibited tissue lipid peroxidation in vitro. Intraperitoneal administration of ginger oil was found to inhibit phorbol-12-myristate-13-acetate induced superoxide radicals elicited by macrophages. Oral administration of ginger oil for one month, significantly increased superoxide dismutase, glutathione and glutathione reductase enzymes level (P < 0.001) in blood of mice and glutathione-S-transferase, glutathione peroxidase and superoxide dismutase enzymes in liver. Ginger oil produced significant reduction in acute inflammation produced by carrageenan and dextran and formalin induced chronic inflammation (P < 0.001). It also exhibited significant reduction in acetic acid induced writhing movements (P < 0.001). The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property.
authors.affiliation: Amala Cancer Research Centre, Amala Nagar, Thrissur--680 555, Kerala, India.
authors.forename: Kottarapat
authors.initials: K
authors.lastname: Jeena
authors.forename: Vijayastelter B
authors.initials: VB
authors.lastname: Liju
authors.forename: Ramadasan
authors.initials: R
authors.lastname: Kuttan
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D020939:Zingiber officinale; D005978:Glutathione / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009822:Oils, Volatile / Q000494:pharmacology*; D051381:Rats; D013481:Superoxides / Q000378:metabolism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D009822:Oils, Volatile; D013481:Superoxides; D005978:Glutathione