title: Intra-arterial chemotherapy for group C retinoblastoma with adjacent high-flow infantile hemangioma.
abstract: Intra-arterial chemotherapy for retinoblastoma is an emerging technique that is being adopted at various centers worldwide. The authors report the first case of an infantile hemangioma that shunted flow during intra-arterial chemotherapy in a 4-month-old girl who presented with macular group C retinoblastoma. Excellent tumor response was noted despite only a fraction of the dose entering the central retinal artery. Further studies to examine intra-arterial chemotherapy's pharmacokinetics and dose-response relations are warranted in order to minimize the necessary exposure to chemotherapy.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: Darren B
authors.initials: DB
authors.lastname: Orbach
authors.forename: Danielle
authors.initials: D
authors.lastname: Trief
authors.forename: Ankoor S
authors.initials: AS
authors.lastname: Shah
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Vanderveen
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D005123:Eye / Q000098:blood supply; D005260:Female; D006391:Hemangioma / Q000098:blood supply / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007269:Injections, Intra-Arterial; D008558:Melphalan / Q000008:administration & dosage*; D009378:Neoplasms, Multiple Primary / Q000098:blood supply / Q000188:drug therapy*; D019572:Retinal Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D012175:Retinoblastoma / Q000098:blood supply / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan