title: Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking.
abstract: Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated.
authors.affiliation: School of Chemical Science, Dublin City University, Dublin, 9, Ireland.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guang-Zhao
authors.initials: GZ
authors.lastname: Li
authors.forename: David M
authors.initials: DM
authors.lastname: Haddleton
authors.forename: Russell
authors.initials: R
authors.lastname: Wallis
authors.forename: Daniel
authors.initials: D
authors.lastname: Mitchell
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
authors.forename: C Remzi
authors.initials: CR
authors.lastname: Becer
mesh_terms: D002942:Circular Dichroism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D020349:Surface Plasmon Resonance
chemical_list: D006020:Glycopeptides; D015699:HIV Envelope Protein gp120; D037102:Lectins; D011108:Polymers
keywords: dendritic cells; glycopolymer-lectin interactions; glycopolymers; glycopolypeptides; resonance; surface plasmon