title: Hypertriglyceridemic waist might be an alternative to metabolic syndrome for predicting future diabetes mellitus.
abstract: BACKGROUND
  In some cross-sectional studies, hypertriglyceridemic waist (HTGW) has been recommended as an alternative to metabolic syndrome (MetS) for screening individuals at high risk for diabetes mellitus (DM). However, little information is about the predictive power of HTGW for future DM. The aims of the study were to assess the DM predictive power of HTGW compared with MetS based on the follow-up data over 15 years collected from a general Chinese population.
  
  
  METHODS
  And Findings: The data were collected in 1992 and then again in 2007 from the same group of 687 individuals without DM in 1992. For the whole population (n =687), multivariate analysis showed presence of HTGW was associated with a 4.1-fold (95%CI: 2.4-7.0, p < 0.001) increased risk and presence of MetS was associated with a 3.7-fold (95%CI: 2.2-6.2, p < 0.001) increased risk for future DM. For the population without elevated fasting plasma glucose (n = 650), multivariate analysis showed presence of HTGW was associated with a 3.9-fold (95%CI: 2.2-7.0, p < 0.001) increased risk and presence of MetS was associated with a 3.7-fold (95%CI: 2.1-6.6, p < 0.001) increased risk for future DM.
  
  
  CONCLUSIONS
  HTGW could predict future DM independently, and the predictive power was similar to MetS. HTGW might be an alternative to MetS for predicting future DM. For simpler and fewer components, HTGW might be more practical than MetS, and it might be recommended in most clinical practices. This finding might be more useful for the individuals who only have elevated WC and TG. Although these individuals are without MetS, they are still at high risk for future DM, similarly to the individuals with MetS.
authors.affiliation: Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Sen
authors.initials: S
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Shu
authors.forename: Jiyun
authors.initials: J
authors.lastname: He
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000097:blood / Q000150:complications*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D014280:Triglycerides
references.citation: Lancet. 2008 Jun 7;371(9628):1927-35
references.pmid: 18501419
references.citation: Eur J Clin Invest. 2012 Oct;42(10):1100-11
references.pmid: 22784553
references.citation: J Res Med Sci. 2011 Feb;16(2):156-64
references.pmid: 22091225
references.citation: PLoS One. 2013;8(1):e50573
references.pmid: 23382801
references.citation: Can J Cardiol. 2007 Oct;23 Suppl B:23B-31B
references.pmid: 17932584
references.citation: CMAJ. 2009 Mar 17;180(6):601-2
references.pmid: 19289800
references.citation: Circulation. 2009 Oct 20;120(16):1640-5
references.pmid: 19805654
references.citation: Diabetes Care. 2013 Feb;36(2):362-8
references.pmid: 22933442
references.citation: CMAJ. 2010 Oct 19;182(15):E722-5
references.pmid: 20855478
references.citation: Rev Prat. 2010 Dec 20;60(10 Suppl):15-23
references.pmid: 22530271
references.citation: Can J Cardiol. 2002 Jul;18(7):725-32
references.pmid: 12167959
references.citation: Atherosclerosis. 2010 Jul;211(1):327-32
references.pmid: 20223457
references.citation: Atherosclerosis. 2007 May;192(1):161-8
references.pmid: 16720024
references.citation: CMAJ. 2011 Jun 14;183(9):E553-8
references.pmid: 21555386
references.citation: Clin Nutr. 2010 Apr;29(2):192-8
references.pmid: 20153095
references.citation: Diabetes Care. 2009 Oct;32(10):1916-20
references.pmid: 19592623
references.citation: Int J Obes (Lond). 2011 Feb;35(2):292-9
references.pmid: 20548300
references.citation: Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36
references.pmid: 22064493
references.citation: Circulation. 2005 Apr 19;111(15):1883-90
references.pmid: 15837940
references.citation: Metabolism. 2009 Aug;58(8):1123-30
references.pmid: 19481769
references.citation: Circulation. 2005 Oct 25;112(17):2735-52
references.pmid: 16157765
references.citation: Int J Cardiol. 2013 Sep 20;168(1):511-4
references.pmid: 23063478
references.citation: Diabetes Care. 2012 Jan;35 Suppl 1:S11-63
references.pmid: 22187469
references.citation: Am J Clin Nutr. 2003 Nov;78(5):928-34
references.pmid: 14594778