title: Predictive factors for recurrence and survival in hepatocellular carcinoma in South Korea.
abstract: OBJECTIVE
  To evaluate the factors predicting for recurrence and to analyze survival of patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  A total of 743 patients who were consecutively diagnosed and treated with HCC were retrospectively analyzed from January 2004 to December 2012 at our institution. We analyzed their survival and tumor recurrence.
  
  
  RESULTS
  On multivariate analysis, age >50 years, CLIP score <3, ALP <120 U/l, LDH <450 IU/l, CRP <0.8 mg/dl, tumor size <6 cm, no distant metastasis, and curative treatment modality were predictors for 1-year survival. CRP <0.8 mg/dl, Child-Pugh score <7, curative treatment modality and tumor size <6 cm were predictors for 3-year survival. Absence of vascular invasion and uninodular tumor type were predictors for 5-year survival. Multinodular tumor, tumor size >4 cm, and palliative treatment were independent risk factors for 1-year recurrence after initial treatment.
  
  
  CONCLUSIONS
  This large study provides a comprehensive overview of the survival outcomes and prognostic factors regarding HCC, according to clinical characteristics, various treatment modalities, and the results will help in the selection of effective treatment strategies future.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Dong-Ku, Gwangju, Korea. estevanj@naver.com.
authors.forename: Chung Hwan
authors.initials: CH
authors.lastname: Jun
authors.forename: Da Woon
authors.initials: DW
authors.lastname: Sim
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Hyoung Ju
authors.initials: HJ
authors.lastname: Hong
authors.forename: Min Woo
authors.initials: MW
authors.lastname: Chung
authors.forename: Eun
authors.initials: E
authors.lastname: Myoung
authors.forename: Han Ra
authors.initials: HR
authors.lastname: Koh
authors.forename: Sung Bum
authors.initials: SB
authors.lastname: Cho
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Rew
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D056910:Republic of Korea; D016019:Survival Analysis
keywords: Hepatocellular carcinoma; recurrence; survival; treatment modality