title: Immunological and microbiological findings after the application of two periodontal surgical techniques: a randomized, controlled clinical trial.
abstract: OBJECTIVE
  To examine microbiological and immunological alterations following two periodontal surgical techniques, over a 6-month period.
  
  
  METHODS
  A total of 30 chronic periodontitis patients participated in the present randomized controlled clinical trial and were randomized in two groups. Modified Widman flap (MWF) was applied in the control group and apically positioned flap (APF), without intervention to the bone, in the experimental group. Gingival crevicular fluid samples and subgingival plaque samples from the operated sites were collected at baseline, 6th, 12th and 24th post-operative week.
  
  
  RESULTS
  No major differences were noticed in immunological and microbiological profile of patients receiving either modified MWF or APF, for a period of 6 months.
  
  
  CONCLUSIONS
  The choice of the periodontal surgical procedure does not seem to affect the immunological and the microbiological profile of patients with chronic periodontitis.
authors.affiliation: Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kyriazis
authors.forename: Sofia
authors.initials: S
authors.lastname: Gkrizioti
authors.forename: Lazaros
authors.initials: L
authors.lastname: Tsalikis
authors.forename: Dimitra
authors.initials: D
authors.lastname: Sakellari
authors.forename: Aristeides
authors.initials: A
authors.lastname: Deligianidis
authors.forename: Antonis
authors.initials: A
authors.lastname: Konstantinidis
mesh_terms: D000190:Actinomyces / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D001439:Bacteroides / Q000302:isolation & purification; D055113:Chronic Periodontitis / Q000276:immunology / Q000382:microbiology / Q000601:surgery*; D003773:Dental Plaque / Q000276:immunology / Q000382:microbiology*; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D011446:Prospective Studies; D016745:Root Planing / Q000379:methods; D034361:Streptococcus mitis / Q000302:isolation & purification; D013524:Surgical Flaps / Q000145:classification / Q000601:surgery*; D048373:Treponema denticola / Q000302:isolation & purification; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: C508606:CXCL8 protein, human; C508609:IL10 protein, human; C508598:IL4 protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4
keywords: cytokines; microbes; periodontal surgical treatment; periodontitis