title: The catalytically active copper-amyloid-Beta state: coordination site responsible for reactive oxygen species production.
abstract: Copper-amyloid-β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid-β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid-β peptides.
authors.affiliation: Université de Toulouse; UPS; UMR 152 PHARMA-DEV, Université Toulouse 3, 31062 Toulouse Cedex 09 (France); Institut de Recherche pour le développement (IRD); UMR 152 PHARMA-DEV, 31062 Toulouse Cedex 09 (France).
authors.forename: Laure-Estelle
authors.initials: LE
authors.lastname: Cassagnes
authors.forename: Vincent
authors.initials: V
authors.lastname: Hervé
authors.forename: Françoise
authors.initials: F
authors.lastname: Nepveu
authors.forename: Christelle
authors.initials: C
authors.lastname: Hureau
authors.forename: Peter
authors.initials: P
authors.lastname: Faller
authors.forename: Fabrice
authors.initials: F
authors.lastname: Collin
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D017382:Reactive Oxygen Species / Q000737:chemistry*; D053719:Tandem Mass Spectrometry
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D017382:Reactive Oxygen Species; D003300:Copper
keywords: amyloid-beta peptide; copper; mass spectrometry; reactive oxygen species; redox chemistry