title: Open total aortic arch reconstruction for patients with advanced age in the era of endovascular repair.
abstract: BACKGROUND
  The aim of this study is to evaluate the influence of advanced age on the postoperative course in open aortic arch repair using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  
  
  METHODS
  Of 158 consecutive patients who underwent open total arch repair between 2008 and 2012, we retrospectively compared outcomes between octogenarians (group E: mean age, 83.0 ± 3.1 years [n = 40]) and their younger counterparts (group Y: mean age, 68.2 ± 10.2 years [n = 118]), and evaluated risk factors for an adverse postoperative course.
  
  
  RESULTS
  The overall 30-day mortality was 7.0% (11/158), and by excluding 54 emergent cases, 30-day mortality was 4.8% (5/104). Ruptured cases were significantly observed in group E (17.5% [7/40] vs 3.4% [4/118]; P = .006). There were no significant differences in postoperative early results, including neurologic adverse events (12.5% [5/40] vs 6.8% [8/118]; P = .317) and 30-day death (12.5% [5/40] vs 5.1% [6/118]; P = .147) between groups E and Y. Multivariate logistic analysis revealed rupture, preoperative consciousness disorder, and extended circulatory arrest time (≥67 minutes) were risk factors for serious complications (neurologic adverse events and 30-day death) (odds ratio [OR], 10.9 [P = .010]; OR, 5.2 [P = .040]; and OR, 3.5 [P = .028], respectively). A ruptured aorta was detected as an independent predictor of postoperative extended intensive care unit and hospital stay by multivariate linear regression analysis (P = .001 and P = .007, respectively).
  
  
  CONCLUSIONS
  Advanced age was not associated with serious postoperative complications and adverse postoperative course.
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan. Electronic address: bassbord1028@yahoo.co.jp.
authors.forename: Arudo
authors.initials: A
authors.lastname: Hiraoka
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Genta
authors.initials: G
authors.lastname: Chikazawa
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Totsugawa
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kuinose
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tamura
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Sakaguchi
authors.affiliation: Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yoshitaka
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000503:physiopathology / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001019:Aortic Rupture / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010477:Perfusion; D011183:Postoperative Complications / Q000401:mortality; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome