title: Current and future biologic markers for disease progression and relapse in testicular germ cell tumors: a review.
abstract: Testicular germ cell tumors represent a biologically unique disease process. These tumors are exquisitely sensitive to platinum-based chemotherapy, can be cured with surgical metastasectomy, and are known for the integration of biologic markers to stage and assign risk. Exploring further biologic markers that offer insight into the molecular mechanisms that contribute to disease biology is important. In this review, we attempt to summarize the utility of the current and some future biologic markers for disease monitoring and relapse.
authors.affiliation: Department of Urology, Indiana University Medical Center, Indianapolis, IN. Electronic address: tamaster@iupui.edu.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Masterson
authors.affiliation: Department of Urology, Indiana University Medical Center, Indianapolis, IN.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Rice
authors.affiliation: Department of Urology, Indiana University Medical Center, Indianapolis, IN.
authors.forename: Stephen D W
authors.initials: SD
authors.lastname: Beck
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D018450:Disease Progression; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods / Q000639:trends*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis*; D013736:Testicular Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor
keywords: Angiogenesis; Biomarkers; Epigenetics; Gene profiling; Germ cell tumor; Serum tumor markers; Testicular cancer