title: Contrast-enhanced ultrasound findings in soft-tissue lesions: preliminary results.
abstract: OBJECTIVE
  There is currently no widely available, minimally invasive first-level examination that allows physicians to identify soft-tissue lesions that are likely to be malignant. The aim of this pilot study was to explore the potential suitability of dynamic contrast-enhanced ultrasound (DCE-US) for this purpose.
  
  
  METHODS
  23 patients were referred to the Veneto Oncological Institute for work-up of superficial soft-tissue lesions. Fourteen lesions were examined with CEUS and enhancement kinetics was analyzed. Subsequently, all lesions were surgically removed and subjected to histological analysis.
  
  
  RESULTS
  The 14 lesions included in the study were histologically classified as malignant (n = 7) or benign (n = 7, including 3 schwannomas). A statistically significant difference between benign and malignant lesions was found in terms of mean times to peak enhancement intensity (p = 0.03) but not mean filling times (FT). When schwannomas were analyzed as a separate group, their mean FT was found to be significantly different from that of the other benign lesions (p = 0.001) and from that of the group comprising other benign lesions as well as malignant lesions (p < 0.005).
  
  
  CONCLUSIONS
  CEUS with analysis of contrast-enhancement kinetics is a relatively low-cost, minimally invasive imaging technique, which appears to be a potentially effective first-level method for identifying suspicious soft-tissue masses.
authors.affiliation: Department of Medicine, Radiology Section, University of Padua, Padua, Italy ; Dipartimento di Medicina, Radiologia, Università di Padova, Via Giustiniani 2, 35128 Padua, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Stramare
authors.forename: M
authors.initials: M
authors.lastname: Gazzola
authors.forename: A
authors.initials: A
authors.lastname: Coran
authors.forename: M
authors.initials: M
authors.lastname: Sommavilla
authors.forename: V
authors.initials: V
authors.lastname: Beltrame
authors.forename: M
authors.initials: M
authors.lastname: Gerardi
authors.forename: G
authors.initials: G
authors.lastname: Scattolin
authors.forename: A
authors.initials: A
authors.lastname: Faccinetto
authors.forename: M
authors.initials: M
authors.lastname: Rastrelli
authors.forename: E
authors.initials: E
authors.lastname: Grisan
authors.forename: M C
authors.initials: MC
authors.lastname: Montesco
authors.forename: C R
authors.initials: CR
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Rubaltelli
keywords: Contrast-enhanced ultrasound; Sarcoma; Soft tissue tumors; Ultrasonography
references.citation: Radiology. 2002 May;223(2):410-6
references.pmid: 11997546
references.citation: Semin Oncol. 1997 Oct;24(5):504-14
references.pmid: 9344316
references.citation: J Magn Reson Imaging. 2013 Apr;37(4):791-804
references.pmid: 22972755
references.citation: AJR Am J Roentgenol. 2011 Jan;196(1):W8-12
references.pmid: 21178038
references.citation: Radiology. 2009 Nov;253(2):297-316
references.pmid: 19864525
references.citation: Ultrasonics. 2011 Jan;51(1):102-6
references.pmid: 20643467
references.citation: Comput Med Imaging Graph. 1996 May-Jun;20(3):163-9
references.pmid: 8930469