title: [A case of esophageal cancer with septic disseminated intravascular coagulation treated with recombinant human soluble thrombomodulin during chemoradiation therapy].
abstract: A 70-year-old woman was diagnosed with synchronous advanced esophageal cancer and early renal cancer. During chemoradiation therapy for the esophageal cancer, she suffered from septic shock due to pneumonia. She got worse despite the administration of antibiotics and gglobulin. On the following day, she was diagnosed with septic disseminated intravascular coagulation(DIC)on the basis of the diagnostic criterion for acute DIC. Recombinant human soluble thrombomodulin(rTM) was administered to treat the DIC. The patient responded promptly to rTM treatment and recovered from the DIC in just 1 day. rTM is thought to be an effective drug for sepsis-induced DIC during chemoradiation therapy.
authors.affiliation: Dept. of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okumura
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Uchikado
authors.forename: Koji
authors.initials: K
authors.lastname: Minami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ijichi
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Owaki
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D004938:Esophageal Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology; D018180:Thrombomodulin / Q000627:therapeutic use*
chemical_list: D018180:Thrombomodulin