title: Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients.
abstract: BACKGROUND
  Cancer-related fatigue (CRF) has been suggested to be associated with the occurrence of chemotherapy-induced nausea and vomiting (CINV). This study aims to evaluate the potential of CRF in predicting the occurrence of CINV.
  
  
  METHODS
  This is a prospective, observational study. Recruited patients received moderately to highly emetogenic single-day chemotherapy regimens. On the day of chemotherapy, patients were instructed to provide a score (Likert scale of 0-10) to describe how CRF interfered with his or her ability to engage in daily activities and a score for how severe it was. Patients were then given a standardized 5-day diary to document their CINV events.
  
  
  RESULTS
  A total of 473 eligible patients (median age: 55 years, interquartile range (IQR): 48-61 years) were recruited, with most of the patients diagnosed with gastrointestinal (45%) and breast (37%) cancers. The median score of fatigue interference was 3 (IQR: 0-5). After confounders were adjusted for, patients with low fatigue interference scores (≤3) were more likely to achieve complete protection (no nausea, no vomiting, and no breakthrough antiemetics) of CINV (adjusted odds ratio = 1.57, 95%CI [1.05, 2.35], p = 0.027).
  
  
  CONCLUSIONS
  This is the largest study to date to evaluate the association between CRF and CINV. Patients experiencing CRF possessed a higher risk of poor control for CINV.
authors.affiliation: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors.forename: Ken Shing Ho
authors.initials: KS
authors.lastname: Poon
authors.forename: Man Kit
authors.initials: MK
authors.lastname: Un
authors.forename: Xiu Hui
authors.initials: XH
authors.lastname: Low
authors.forename: Yin Ting
authors.initials: YT
authors.lastname: Cheung
authors.forename: Kevin Yi-Lwern
authors.initials: KY
authors.lastname: Yap
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*; D005221:Fatigue / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012846:Singapore / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents
keywords: anticancer treatment; anxiety; cancer; chemotherapy; fatigue; nausea and vomiting; pharmacoepidemiology