title: Relationship between estimated glomerular filtration rate, albuminuria, and oxidant status in the Japanese population.
abstract: BACKGROUND
  In the general population, reported levels of oxidative stress and antioxidant potential seem to vary. The aim of this study was to investigate the levels of oxidant status markers in relation to estimated glomerular filtration rate (eGFR) and albuminuria in Japanese population.
  
  
  METHODS
  Data were analyzed from 8335 individuals who underwent a general health screening test. For the estimation of albuminuria, urinary albumin-to-creatinine ratio (UAER) was calculated. Oxidant status was determined by assessing derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP).
  
  
  RESULTS
  After adjusting for age, high blood pressure, depressor agent use, CRP, smoking status, multivariate logistic regression analysis showed that the lowest eGFR quartile was associated negatively with the top d-ROM quartile in men (odds ratio 0.78 [95% CI 0.62-0.98, P = 0.034]) and the highest UAER was associated with the top d-ROM in men (odds ratio 1.68) [95% CI 1.35-2.10, P < 0.001]. In addition, both the first eGFR quartile and the fourth UAER quartile showed significant positive association with low BAP levels in men, but not in women.
  
  
  CONCLUSIONS
  Among men who underwent general health screening, lower eGFR and increased albuminuria was negatively and positively, respectively, associated with higher oxidative stress levels, whereas both conditions were positively associated with lower antioxidant potential levels.
authors.affiliation: Department of Cardiology, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-shi, 569-8686 Osaka, Japan. ishizaka@poh.osaka-med.ac.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Akiko
authors.initials: A
authors.lastname: Toda
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tani
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D000419:Albuminuria / Q000453:epidemiology* / Q000503:physiopathology*; D015984:Causality; D015897:Comorbidity; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D017382:Reactive Oxygen Species
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