title: Neuronal development: SAD kinases make happy axons.
abstract: The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.
authors.affiliation: Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Jason M
authors.initials: JM
authors.lastname: Newbern
authors.forename: William D
authors.initials: WD
authors.lastname: Snider
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D006801:Humans; D020933:Neurotrophin 3 / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020933:Neurotrophin 3; D017346:Protein Serine-Threonine Kinases
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