title: [Changes in the European baseline series from 1981 to 2011 in a French dermatology-allergology centre].
abstract: BACKGROUND
  Periodically updated, the European baseline series (EBS), first introduced in France in 1980, is an indispensable tool for the exploration of contact allergy. The aim of our study was to describe the prevalence of contact sensitization in a French centre between 1981 and 2011 to determine whether certain allergens may be deleted from the current BSE.
  
  
  METHODS
  A retrospective study was conducted in a department of dermatology-allergology to analyse the results of all EBS tests performed every 10 years, from 1981 to 2001, and annually from 2007 to 2011. Some added allergens, introduced in 2010, were also studied. Changes in allergen positivity were analysed using a Cochran-Armitage test.
  
  
  RESULTS
  Among the 4551 patients included for the 8-year period studied, the prevalence of positivity was 42.91%. The most common allergens in the general population were nickel sulphate (17.25%), with a constantly increasing prevalence, Myroxylon pereirae (10.68%), fragrance mix I (8.11%), cobalt chloride (6.99%) and chromium (6.33%). The least frequent sensitizations, with a decreasing prevalence, were found with clioquinol (0.25%), primin (0.54%) and benzocaine (0.55%).
  
  
  CONCLUSIONS
  Due to modifications in exposure to allergens, the incidence of contact sensitization can change, but nickel sulphate sensitization is increasing despite recent European directives. Allergens with less than 1% of positive results could be withdrawn from the EBS, with benzalkonium chloride, methylisothiazolinone and lavender absolute being added.
authors.affiliation: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54511 Vandœuvre-lès-Nancy cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Schoeffler
authors.forename: J
authors.initials: J
authors.lastname: Waton
authors.forename: C
authors.initials: C
authors.lastname: Latarche
authors.forename: C
authors.initials: C
authors.lastname: Poreaux
authors.forename: J-F
authors.initials: JF
authors.lastname: Cuny
authors.forename: J-L
authors.initials: JL
authors.lastname: Schmutz
authors.forename: A
authors.initials: A
authors.lastname: Barbaud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects / Q000145:classification; D052179:Antigens, Plant / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003358:Cosmetics / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D004485:Eczema / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005079:Excipients / Q000009:adverse effects; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D020315:Latex Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D010328:Patch Tests / Q000592:standards* / Q000706:statistics & numerical data; D010476:Perfume / Q000009:adverse effects; D010969:Plastics / Q000009:adverse effects; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D003358:Cosmetics; D005079:Excipients; D008670:Metals; D010476:Perfume; D010969:Plastics
keywords: Allergen; Allergène; Batterie standard européenne; European baseline series; Evolution; Patch testing; Patch-test; Évolution