title: Liposomal extended-release bupivacaine for postsurgical analgesia.
abstract: When physicians consider which analgesia to use postsurgery, the primary goal is to relieve pain with minimal adverse side effects. Bupivacaine, a commonly used analgesic, has been formulated into an aqueous suspension of multivesicular liposomes that provide long-lasting analgesia for up to 72 hours, while avoiding the adverse side effects of opioids. The increased efficacy of liposomal extended-release bupivacaine, compared to bupivacaine hydrochloride, has promoted its usage in a variety of surgeries including hemorrhoidectomy, bunionectomy, inguinal hernia repair, total knee arthroplasty, and augmentation mammoplasty. However, like other bupivacaine formulations, the liposomal extended-release bupivacaine does have some side effects. In this brief review, we provide an update of the current knowledge in the use of bupivacaine for postsurgical analgesia.
authors.affiliation: Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA ; Department of Orthopaedic Surgery and Tulane institute of Sports Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Lambrechts
authors.forename: Michael J
authors.initials: MJ
authors.lastname: O'Brien
authors.forename: Felix H
authors.initials: FH
authors.lastname: Savoie
authors.forename: Zongbing
authors.initials: Z
authors.lastname: You
keywords: analgesia; bupivacaine; efficacy; liposome; patient satisfaction; side effects
references.citation: J Pain Res. 2012;5:107-16
references.pmid: 22570563
references.citation: Binocul Vis Strabolog Q Simms Romano. 2012;27(1):15-22
references.pmid: 22404088
references.citation: J Bone Joint Surg Am. 2010 Mar;92(3):599-608
references.pmid: 20194318
references.citation: Adv Ther. 2011 Sep;28(9):776-88
references.pmid: 21842428
references.citation: Spine J. 2012 Aug;12(8):665-73
references.pmid: 22819189
references.citation: J Pain Res. 2012;5:567-72
references.pmid: 23204866
references.citation: Anesthesiology. 1985 Apr;62(4):396-405
references.pmid: 2580463
references.citation: Knee. 2012 Oct;19(5):530-6
references.pmid: 22285545
references.citation: Ann Pharmacother. 2007 Mar;41(3):400-6
references.pmid: 17341537
references.citation: Anesthesiology. 2010 Sep;113(3):560-9
references.pmid: 20683254
references.citation: Expert Opin Investig Drugs. 2011 Oct;20(10):1327-41
references.pmid: 21867476
references.citation: Anesth Analg. 1998 Apr;86(4):797-804
references.pmid: 9539605
references.citation: J AAPOS. 2010 Aug;14(4):323-7
references.pmid: 20736123
references.citation: J Clin Pharmacol. 2012 Sep;52(9):1441-7
references.pmid: 22058388
references.citation: Spine J. 2011 Feb;11(2):139-46
references.pmid: 21296298
references.citation: Curr Med Res Opin. 2012 Oct;28(10):1609-15
references.pmid: 22900785
references.citation: Knee Surg Sports Traumatol Arthrosc. 2011 Dec;19(12):2138-44
references.pmid: 21647658
references.citation: Am J Med Qual. 2012 Sep-Oct;27(5):411-6
references.pmid: 22345130
references.citation: Anesthesiology. 2004 May;100(5):1305-7
references.pmid: 15114230
references.citation: Arthroscopy. 2010 Apr;26(4):451-61
references.pmid: 20362823
references.citation: Anesth Analg. 1989 Dec;69(6):794-801
references.pmid: 2511782
references.citation: Acta Anaesthesiol Scand. 2001 Aug;45(7):795-804
references.pmid: 11472277
references.citation: J Pain Res. 2012;5:257-64
references.pmid: 23049275
references.citation: Pain Physician. 2008 Mar;11(2 Suppl):S105-20
references.pmid: 18443635
references.citation: Anesthesiology. 2009 Nov;111(5):1120-7
references.pmid: 19809284
references.citation: Reg Anesth Pain Med. 2004 Nov-Dec;29(6):557-63
references.pmid: 15635515
references.citation: Am Surg. 2012 May;78(5):574-81
references.pmid: 22546131
references.citation: Acta Anaesthesiol Scand. 1989 Jan;33(1):84-8
references.pmid: 2916392
references.citation: Clin J Pain. 2014 Feb;30(2):102-10
references.pmid: 23446090
references.citation: Can J Anaesth. 1992 Feb;39(2):192-7
references.pmid: 1544204
references.citation: Clin Ther. 2013 Mar;35(3):312-320.e5
references.pmid: 23453403
references.citation: Drug Saf. 2002;25(3):153-63
references.pmid: 11945112
references.citation: Anesthesiology. 2002 Sep;97(3):710-6
references.pmid: 12218539
references.citation: Acta Biomed. 2008 Aug;79(2):92-105
references.pmid: 18788503
references.citation: Br J Anaesth. 2000 Jan;84(1):6-10
references.pmid: 10740539
references.citation: J Bone Joint Surg Am. 2011 Apr 6;93(7):615-25
references.pmid: 21357481
references.citation: Spine J. 2010 Feb;10(2):159-66
references.pmid: 19800297
references.citation: J Bone Joint Surg Br. 2008 Jun;90(6):814-20
references.pmid: 18539679
references.citation: Anesth Analg. 2000 Dec;91(6):1473-8
references.pmid: 11094003
references.citation: Aesthet Surg J. 2012 Jan;32(1):69-76
references.pmid: 22179931
references.citation: Anesth Analg. 2006 Nov;103(5):1322-6
references.pmid: 17056977
references.citation: Am J Sports Med. 2012 Jun;40(6):1375-83
references.pmid: 22427617
references.citation: Spine J. 2011 Jan;11(1):46-53
references.pmid: 21168098
references.citation: J Drug Deliv. 2012;2012:962101
references.pmid: 22363842
references.citation: Anesthesiology. 2009 Mar;110(3):648-59
references.pmid: 19212263
references.citation: Am J Sports Med. 2011 Oct;39(10):2245-53
references.pmid: 21515808
references.citation: Dis Colon Rectum. 2011 Dec;54(12):1552-9
references.pmid: 22067185
references.citation: J Pak Med Assoc. 2009 Jun;59(6):385-8
references.pmid: 19534374