title: 5-Florouracil-loaded poly(lactic acid)-poly(caprolactone) hybrid scaffold: potential chemotherapeutic implant.
abstract: Hybrid nanofibers of poly(lactic acid) and polycaprolactone have been developed by embedding cancerous drug through electrospinning technique. The composition of polymer has been varied to check the compositional effect on properties. The quality of nanofibers has been testified through surface morphology, wetting properties using contact angle and mechanical strength under uniaxial elongation. The compatibility of drug (5-fluorourasil) with matrix fiber has been verified using Fourier transform infrared, X-ray diffraction, Raman spectroscopy, and differential scanning calorimetry. The drug release study has been performed showing greater release in hybrid fibers when compared with pure polymers as a result of synergism of two immiscible polymers and quasi-Fickian diffusion mechanism in hybrid nanofiber as implants showing compositional effect on drug release. A model has been proposed showing faster release of drugs in hybrid systems. Biological responses through fluorescence imaging and MTT assay confirm the release of drug from hybrid nanofibers showing potential use of hybrid scaffolds as chemotherapeutic implant.
authors.affiliation: Department of Chemical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India.
authors.forename: Kamal K
authors.initials: KK
authors.lastname: Gupta
authors.forename: Namrata
authors.initials: N
authors.lastname: Pal
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Mishra
authors.forename: Pradeep
authors.initials: P
authors.lastname: Srivastava
authors.forename: Sujata
authors.initials: S
authors.lastname: Mohanty
authors.forename: Pralay
authors.initials: P
authors.lastname: Maiti
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003460:Crystallization; D005472:Fluorouracil / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020007:Implants, Experimental; D057139:Nanofibers / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D013314:Stress, Mechanical; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D011091:Polyesters; C550605:poly(lactic acid-co-epsilon-caprolactone); D005472:Fluorouracil
keywords: 5-florouracil; hybrid; nanofibers; osteoblast cell; poly(lactic acid); polycaprolactone