title: Bioeffects of static magnetic fields: oxidative stress, genotoxic effects, and cancer studies.
abstract: The interaction of static magnetic fields (SMFs) with living organisms is a rapidly growing field of investigation. The magnetic fields (MFs) effect observed with radical pair recombination is one of the well-known mechanisms by which MFs interact with biological systems. Exposure to SMF can increase the activity, concentration, and life time of paramagnetic free radicals, which might cause oxidative stress, genetic mutation, and/or apoptosis. Current evidence suggests that cell proliferation can be influenced by a treatment with both SMFs and anticancer drugs. It has been recently found that SMFs can enhance the anticancer effect of chemotherapeutic drugs; this may provide a new strategy for cancer therapy. This review focuses on our own data and other data from the literature of SMFs bioeffects. Three main areas of investigation have been covered: free radical generation and oxidative stress, apoptosis and genotoxicity, and cancer. After an introduction on SMF classification and medical applications, the basic phenomena to understand the bioeffects are described. The scientific literature is summarized, integrated, and critically analyzed with the help of authoritative reviews by recognized experts; international safety guidelines are also cited.
authors.affiliation: Université de Carthage, Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Jarzouna, Tunisia.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Ghodbane
authors.forename: Aida
authors.initials: A
authors.lastname: Lahbib
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
mesh_terms: D017209:Apoptosis / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004249:DNA Damage / Q000528:radiation effects; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D060526:Magnetic Fields; D018384:Oxidative Stress / Q000528:radiation effects*
chemical_list: D005609:Free Radicals
references.citation: Front Biosci. 2008 May 01;13:6106-25
references.pmid: 18508647
references.citation: Bioelectromagnetics. 2006 Feb;27(2):151-5
references.pmid: 16304696
references.citation: Environ Toxicol Pharmacol. 2011 Jan;31(1):100-6
references.pmid: 21787674
references.citation: Med Biol Eng Comput. 2010 Aug;48(8):793-8
references.pmid: 20521172
references.citation: Br J Psychiatry. 1994 Mar;164(3):403-9
references.pmid: 8199794
references.citation: FASEB J. 1992 Sep;6(12):3051-64
references.pmid: 1381691
references.citation: Pathophysiology. 2001 Mar;7(4):283-288
references.pmid: 11228399
references.citation: Prog Biophys Mol Biol. 2005 Feb-Apr;87(2-3):213-23
references.pmid: 15556660
references.citation: Pathophysiology. 2009 Aug;16(2-3):79-88
references.pmid: 19264461
references.citation: Phys Med Biol. 2007 Feb 21;52(4):889-98
references.pmid: 17264359
references.citation: Arch Med Res. 2006 Nov;37(8):941-6
references.pmid: 17045108
references.citation: Photochem Photobiol. 1998 Jan;67(1):111-8
references.pmid: 9477768
references.citation: Bioelectromagnetics. 2011 Apr;32(3):191-9
references.pmid: 21365663
references.citation: Cytometry A. 2006 Feb;69(2):75-85
references.pmid: 16419064
references.citation: Cytometry. 2002 Dec 1;49(4):143-9
references.pmid: 12454977
references.citation: J Trace Elem Electrolytes Health Dis. 1991 Sep;5(3):181-6
references.pmid: 1821720
references.citation: Health Phys. 2009 Apr;96(4):504-14
references.pmid: 19276710
references.citation: J Toxicol Environ Health A. 1998 May 8;54(1):63-76
references.pmid: 9588349
references.citation: Bioelectromagnetics. 2000 Dec;21(8):575-83
references.pmid: 11102947
references.citation: Bioelectromagnetics. 2008 Dec;29(8):605-14
references.pmid: 18512716
references.citation: Gen Physiol Biophys. 2007 Jun;26(2):86-90
references.pmid: 17660581
references.citation: J Neurol Sci. 1995 Dec;134 Suppl:33-44
references.pmid: 8847543
references.citation: Bioelectromagnetics. 1995;16(1):20-32
references.pmid: 7748200
references.citation: Mutat Res. 1999 Jun 30;427(2):147-56
references.pmid: 10393268
references.citation: Tissue Cell. 2009 Jun;41(3):169-79
references.pmid: 19054536
references.citation: Arch Toxicol. 1996;70(5):315-8
references.pmid: 8852704
references.citation: Bioelectromagnetics. 2010 Dec;31(8):649-55
references.pmid: 20830734
references.citation: Bioelectromagnetics. 1996;17(5):358-63
references.pmid: 8915544
references.citation: Mutat Res. 1993 Jul;297(1):61-95
references.pmid: 7686274
references.citation: Apoptosis. 2006 Mar;11(3):359-65
references.pmid: 16528477
references.citation: Bioelectromagnetics. 2010 Dec;31(8):630-9
references.pmid: 20623760
references.citation: Tohoku J Exp Med. 1996 Nov;180(3):209-15
references.pmid: 9058505
references.citation: Ann N Y Acad Sci. 2006 Dec;1090:59-68
references.pmid: 17384247
references.citation: Free Radic Biol Med. 1997;23(1):134-47
references.pmid: 9165306
references.citation: Micron. 2005;36(3):195-217
references.pmid: 15725590
references.citation: Environ Toxicol Pharmacol. 2007 Mar;23(2):193-7
references.pmid: 21783757
references.citation: Mutagenesis. 2001 Nov;16(6):499-501
references.pmid: 11682641
references.citation: J Neural Transm (Vienna). 2006 Jul;113(7):821-7
references.pmid: 16252069
references.citation: Toxicol Ind Health. 2011 Nov;27(10):949-55
references.pmid: 21505001
references.citation: Bioelectromagnetics. 2011 Feb;32(2):94-101
references.pmid: 21225886
references.citation: J Magn Reson Imaging. 2009 Nov;30(5):1047-51
references.pmid: 19780188
references.citation: Burns. 2005 May;31(3):366-71
references.pmid: 15774296
references.citation: Cytotechnology. 2010 Apr;62(2):143-55
references.pmid: 20464482
references.citation: Bioelectromagnetics. 2005 May;26(4):275-86
references.pmid: 15832333
references.citation: Ind Health. 1997 Apr;35(2):285-90
references.pmid: 9127563
references.citation: Electromagn Biol Med. 2008;27(4):393-401
references.pmid: 19037788
references.citation: Bioelectrochemistry. 2002 Sep;57(2):107-111
references.pmid: 12160605
references.citation: Environ Mutagen. 1984;6(2):153-88
references.pmid: 6423380
references.citation: Bioelectromagnetics. 2010 May;31(4):255-61
references.pmid: 19953573
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2002;80:1-395
references.pmid: 12071196
references.citation: Int J Radiat Biol. 2003 Apr;79(4):281-6
references.pmid: 12775452
references.citation: Arch Med Res. 2006 Nov;37(8):947-52
references.pmid: 17045109
references.citation: FASEB J. 1997 Feb;11(2):118-24
references.pmid: 9039953
references.citation: Gen Physiol Biophys. 2009 Sep;28(3):260-5
references.pmid: 20037191
references.citation: Bioelectromagnetics. 2011 Oct;32(7):535-42
references.pmid: 21412810
references.citation: Med Pr. 2003;54(1):23-8
references.pmid: 12731401
references.citation: Cancer Biother Radiopharm. 2010 Aug;25(4):401-8
references.pmid: 20707721
references.citation: Gen Physiol Biophys. 2012 Mar;31(1):1-10
references.pmid: 22447825
references.citation: Cancer Biol Ther. 2008 Jun;7(6):814-9
references.pmid: 18340115
references.citation: Mutat Res. 1997 Jan 3;373(1):55-60
references.pmid: 9015153
references.citation: J Magn Reson Imaging. 2001 Dec;14(6):779-88
references.pmid: 11747036
references.citation: Gen Physiol Biophys. 2009 Dec;28(4):414-9
references.pmid: 20097964
references.citation: Bioelectromagnetics. 2007 Jan;28(1):42-7
references.pmid: 16988990
references.citation: Mutat Res. 2000 Sep 20;453(1):89-96
references.pmid: 11006416
references.citation: Cancer Biol Ther. 2009 Sep;8(18):1756-62
references.pmid: 19633422
references.citation: Apoptosis. 2010 Sep;15(9):1147-64
references.pmid: 20336374
references.citation: FEBS Lett. 1990 Oct 1;271(1-2):157-60
references.pmid: 2226799
references.citation: Ecotoxicol Environ Saf. 2008 Nov;71(3):895-902
references.pmid: 17996303
references.citation: Bioelectromagnetics. 2011 Feb;32(2):140-7
references.pmid: 21225891
references.citation: J Magn Reson Imaging. 2007 Nov;26(5):1308-14
references.pmid: 17969164
references.citation: Health Phys. 1994 Jan;66(1):100-6
references.pmid: 8253572
references.citation: Radiology. 2002 Sep;224(3):817-22
references.pmid: 12202720
references.citation: Int J Radiat Biol. 1996 Jan;69(1):3-24
references.pmid: 8601753
references.citation: Bioelectrochemistry. 2002 May 15;56(1-2):227-31
references.pmid: 12009481
references.citation: Pharmacol Res. 2003 Jul;48(1):83-90
references.pmid: 12770519
references.citation: Biophys J. 2008 Mar 1;94(5):1565-74
references.pmid: 17981903
references.citation: Micron. 2010 Feb;41(2):101-4
references.pmid: 19926297
references.citation: Cytometry. 2002 Nov 1;49(3):113-8
references.pmid: 12442311
references.citation: Biosystems. 1977 Apr;8(4):163-78
references.pmid: 328072
references.citation: FASEB J. 1999 Jan;13(1):95-102
references.pmid: 9872934
references.citation: Pathophysiology. 2000 Jul;7(2):149-152
references.pmid: 10927196
references.citation: Bioelectromagnetics. 1999;20(3):133-60
references.pmid: 10194557
references.citation: Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28
references.pmid: 11076791
references.citation: Prog Biophys Mol Biol. 2005 Feb-Apr;87(2-3):225-39
references.pmid: 15556661
references.citation: Redox Rep. 2001;6(4):229-34
references.pmid: 11642713
references.citation: Tumori. 2011 May-Jun;97(3):386-92
references.pmid: 21789021
references.citation: Toxicol Ind Health. 2011 Mar;27(2):99-106
references.pmid: 20837562