title: Interaction of carbamazepine with herbs, dietary supplements, and food: a systematic review.
abstract: Background. Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ. Method. A systematic review was conducted on six English databases and four Chinese databases. Results. 196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified. No fatal or severe interactions were documented. The majority of the interactions were pharmacokinetic-based (80%). Traditional Chinese medicine accounted for most of the interactions (n = 17), followed by food (n = 10), dietary supplements (n = 3), and other herbs/botanicals (n = 3). Coadministration of 11 and 12 of the studied herbal products/dietary supplement/food significantly decreased or increased the plasma concentrations of CBZ. Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin, and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ. Conclusion. This review provides a comprehensive summary of the documented interactions between CBZ and herbal products/food/dietary supplements which assists healthcare professionals to identify potential herb-drug and food-drug interactions, thereby preventing potential adverse events and improving patients' therapeutic outcomes when prescribing CBZ.
authors.affiliation: School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
authors.forename: Sophia Yui Kau
authors.initials: SY
authors.lastname: Fong
authors.forename: Qiong
authors.initials: Q
authors.lastname: Gao
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zuo
references.citation: J Psychiatr Res. 2007 Nov;41(10):828-36
references.pmid: 17010995
references.citation: Cancer Chemother Pharmacol. 1994;34 Suppl:S41-5
references.pmid: 8070026
references.citation: Pharmacol Biochem Behav. 1996 Aug;54(4):639-44
references.pmid: 8853183
references.citation: Med Toxicol Adverse Drug Exp. 1989 Mar-Apr;4(2):95-107
references.pmid: 2654545
references.citation: Eur J Drug Metab Pharmacokinet. 2000 Jul-Dec;25(3-4):223-6
references.pmid: 11420894
references.citation: Epilepsy Behav. 2005 Feb;6(1):59-62
references.pmid: 15652735
references.citation: Neurol India. 1998 Jul-Sep;46(3):229-231
references.pmid: 29508782
references.citation: Eur J Clin Pharmacol. 2000 Dec;56(9-10):659-64
references.pmid: 11214772
references.citation: Epilepsia. 1994 Mar-Apr;35(2):344-51
references.pmid: 8156955
references.citation: Biochem Pharmacol. 1991 Mar 1;41(5):838-41
references.pmid: 1900159
references.citation: Coll Antropol. 2009 Jun;33(2):659-63
references.pmid: 19662794
references.citation: Pharmacoepidemiol Drug Saf. 2002 Sep;11(6):457-63
references.pmid: 12426930
references.citation: Pharmacoepidemiol Drug Saf. 2010 Mar;19(3):289-95
references.pmid: 20077522
references.citation: Indian J Exp Biol. 1998 Jan;36(1):112-4
references.pmid: 9536660
references.citation: Epilepsia. 1987;28 Suppl 3:S64-70
references.pmid: 2961558
references.citation: Indian J Exp Biol. 2012 Jan;50(1):51-5
references.pmid: 22279941
references.citation: Alcohol. 1989 Jul-Aug;6(4):297-301
references.pmid: 2765198
references.citation: Methods Find Exp Clin Pharmacol. 2003 Sep;25(7):537-40
references.pmid: 14571284
references.citation: Soc Sci Med. 1999 Nov;49(10):1333-47
references.pmid: 10509824
references.citation: Ther Drug Monit. 2005 Oct;27(5):549-57
references.pmid: 16175124
references.citation: Eur Neuropsychopharmacol. 1999 Mar;9(3):185-90
references.pmid: 10208286
references.citation: Epilepsy Res. 2009 Mar;84(1):21-7
references.pmid: 19135869
references.citation: Int J Clin Pract. 2012 Nov;66(11):1056-78
references.pmid: 23067030
references.citation: Epilepsia. 2008 Mar;49(3):373-80
references.pmid: 17941846
references.citation: Epilepsy Res. 1992 Apr;11(2):147-50
references.pmid: 1618180
references.citation: Br J Clin Pharmacol. 2006 Mar;61(3):246-55
references.pmid: 16487217
references.citation: Xenobiotica. 2002 Jun;32(6):451-78
references.pmid: 12160480
references.citation: Clin Pharmacol Ther. 2000 Dec;68(6):605-12
references.pmid: 11180020
references.citation: Toxicol Appl Pharmacol. 2012 Sep 15;263(3):315-22
references.pmid: 22813711
references.citation: PLoS One. 2008 Jul 16;3(7):e2697
references.pmid: 18628990
references.citation: Seizure. 2004 Sep;13(6):425-33
references.pmid: 15276147
references.citation: Biochim Biophys Acta. 1992 Jun 9;1139(1-2):20-4
references.pmid: 1610916
references.citation: Clin Pharmacokinet. 1996 Sep;31(3):198-214
references.pmid: 8877250
references.citation: Regul Toxicol Pharmacol. 1988 Dec;8(4):389-98
references.pmid: 3222480
references.citation: Biol Pharm Bull. 2002 Nov;25(11):1461-6
references.pmid: 12419960
references.citation: Neurology. 1982 Sep;32(9):965-9
references.pmid: 6810206
references.citation: Ther Drug Monit. 1998 Dec;20(6):652-7
references.pmid: 9853982
references.citation: Epilepsia. 2004 Dec;45(12):1636-9
references.pmid: 15571523
references.citation: Planta Med. 2011 Mar;77(4):311-21
references.pmid: 21049395
references.citation: Biol Pharm Bull. 2002 Apr;25(4):532-5
references.pmid: 11995940
references.citation: Mayo Clin Proc. 2000 Sep;75(9):933-42
references.pmid: 10994829
references.citation: Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):31-3
references.pmid: 11980385
references.citation: Phytother Res. 2009 Nov;23(11):1553-8
references.pmid: 19370549
references.citation: Eur J Drug Metab Pharmacokinet. 2001 Jan-Jun;26(1-2):129-35
references.pmid: 11554427
references.citation: J Pharm Sci. 2005 Jul;94(7):1467-83
references.pmid: 15920768
references.citation: Drug Metab Dispos. 2005 May;33(5):644-8
references.pmid: 15673597
references.citation: Phytother Res. 2009 Sep;23(9):1281-6
references.pmid: 19283724
references.citation: Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):833-54
references.pmid: 22568396
references.citation: J Altern Complement Med. 2001 Dec;7(6):667-80
references.pmid: 11822615
references.citation: Am J Clin Nutr. 1989 Jan;49(1):127-31
references.pmid: 2911998
references.citation: Epilepsia. 1990 May-Jun;31(3):318-23
references.pmid: 2344849
references.citation: J Clin Psychopharmacol. 1991 Jun;11(3):198-203
references.pmid: 2066459
references.citation: Fundam Clin Pharmacol. 2010 Jun;24(3):351-5
references.pmid: 19682087
references.citation: Drugs. 2005;65(9):1239-82
references.pmid: 15916450
references.citation: Methods Find Exp Clin Pharmacol. 2004 Mar;26(2):99-102
references.pmid: 15071607
references.citation: Ann Neurol. 1994 Jun;35(6):743-6
references.pmid: 8210232
references.citation: Indian J Physiol Pharmacol. 1998 Oct;42(4):527-32
references.pmid: 10874355
references.citation: Clin Pharmacol Ther. 1998 Sep;64(3):286-8
references.pmid: 9757152
references.citation: Ann N Y Acad Sci. 1996 Dec 13;803:173-80
references.pmid: 8993510
references.citation: Cancer Res. 1990 Mar 15;50(6):1715-20
references.pmid: 2306725
references.citation: Indian J Exp Biol. 2002 May;40(5):560-3
references.pmid: 12622202
references.citation: Methods Find Exp Clin Pharmacol. 2004 Oct;26(8):634-8
references.pmid: 15605125
references.citation: Ther Drug Monit. 1998 Feb;20(1):56-9
references.pmid: 9485555
references.citation: J Clin Pharm Ther. 2000 Apr;25(2):125-9
references.pmid: 10849190
references.citation: Biol Pharm Bull. 1999 May;22(5):527-31
references.pmid: 10375176
references.citation: Eur J Clin Pharmacol. 1992;43(4):393-7
references.pmid: 1451719
references.citation: Daru. 2010;18(4):254-9
references.pmid: 22615624
references.citation: J Toxicol Clin Toxicol. 1988;26(7):477-86
references.pmid: 3068370
references.citation: J Ethnopharmacol. 2004 Jan;90(1):145-50
references.pmid: 14698522
references.citation: Drug Metab Dispos. 2006 Mar;34(3):343-5
references.pmid: 16326816
references.citation: Epilepsy Behav. 2007 Jun;10(4):576-82
references.pmid: 17459780
references.citation: PLoS One. 2012;7(10):e46296
references.pmid: 23077505