title: {2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone.
abstract: The asymmetric unit of the title compound, C21H13ClFNO2S, contains two independent mol-ecules with similar conformations. In the mol-ecules, the thia-zole ring is essentially planar [maximum atomic deviations = 0.014 (4) and 0.023 (5) Å] and is oriented with respect to the fluoro-phenyl ring and chloro-phenyl rings at 9.96 (18) and 70.39 (18)° in one mol-ecule and at 7.50 (18) and 68.43 (18)° in the other; the dihedral angles between the fluoro-phenyl and chloro-phenyl rings are 64.9 (2) and 64.6 (2)°, respectively. Inter-molecular C-H⋯O and C-H⋯F hydrogen bonds stabilize the three-dimensional supra-molecular architecture. Weak C-H⋯π and π-π inter-actions [centroid-centroid distance = 3.877 (3) Å] lead to a criss-cross mol-ecular packing along the c axis.
authors.affiliation: School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa.
authors.forename: K N
authors.initials: KN
authors.lastname: Venugopala
authors.forename: Susanta K
authors.initials: SK
authors.lastname: Nayak
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.forename: Glenn E M
authors.initials: GE
authors.lastname: Maguire
references.citation: Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3125
references.pmid: 23284450
references.citation: Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55
references.pmid: 19171970
references.citation: Eur J Med Chem. 2010 Apr;45(4):1323-31
references.pmid: 20056520
references.citation: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references.pmid: 18156677
references.citation: Acta Crystallogr Sect E Struct Rep Online. 2013 Jan 1;69(Pt 1):o70
references.pmid: 23476451
references.citation: Bioorg Med Chem Lett. 2012 Jan 1;22(1):649-52
references.pmid: 22079026