title: Treatment of the postoperative recurrence of lung cancer in octogenarians.
abstract: OBJECTIVE
  Guidelines for the treatment of postoperative recurrent lung cancer in octogenarians do not exist. In this study, we investigated the prognosis of patients with recurrence after the resection of lung cancer and discuss the management of recurrent tumors in octogenarians.
  
  
  METHODS
  This study clinicopathologically evaluated 135 octogenarians who underwent resections for lung cancer at a single institution between 1992 and 2010. We retrospectively reviewed the clinical records of 37 patients with confirmed recurrence. The overall survival of the patients and the treatments used for postoperative recurrence were evaluated.
  
  
  RESULTS
  Among 37 patients, six underwent intensive treatment, 14 underwent palliative treatment and 17 received supportive care only. The overall survival rates of the patients in the antitumor treatment groups tended to be associated with a better prognoses than those of the patients in the supportive care only group, but they did not exhibit significantly better prognoses at 1 year (p = 0.202). However, among the patients with a good performance status, the intensive treatment group tended to exhibit prolonged survival. Of the 37 patients with recurrent tumors, five (14%) died of other diseases.
  
  
  CONCLUSIONS
  Antitumor treatment of postoperative recurrent lung cancer in octogenarians may not always improve the survival rate. However, carefully selecting patients for intensive therapy, such as those with a good performance status, may lead to longer survival rates after postoperative recurrence in octogenarians.
authors.affiliation: Department of Chest Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Basyaku, Kokurakita-ku, Kitakyushu, 802-0077, Japan, ikyoku189@kmmc.jp.
authors.forename: Manabu
authors.initials: M
authors.lastname: Yasuda
authors.forename: Akira
authors.initials: A
authors.lastname: Nagashima
authors.forename: Akira
authors.initials: A
authors.lastname: Haro
authors.forename: Genkichi
authors.initials: G
authors.lastname: Saitoh
mesh_terms: D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
references.citation: Am J Clin Oncol. 1982 Dec;5(6):649-55
references.pmid: 7165009
references.citation: Ann Oncol. 2011 Jul;22(7):1520-1527
references.pmid: 21252061
references.citation: Lung Cancer. 1999 Feb;23(2):129-33
references.pmid: 10217616
references.citation: Lung Cancer. 2005 Aug;49(2):193-202
references.pmid: 16022913
references.citation: J Clin Oncol. 2008 Jan 1;26(1):60-5
references.pmid: 18165641
references.citation: Crit Rev Oncol Hematol. 2005 Sep;55(3):241-52
references.pmid: 16084735
references.citation: N Engl J Med. 2002 Jan 10;346(2):92-8
references.pmid: 11784875
references.citation: Ann Thorac Surg. 1994 Jan;57(1):188-92; discussion 192-3
references.pmid: 8279888
references.citation: J Thorac Oncol. 2007 Nov;2(11):1013-7
references.pmid: 17975492
references.citation: J Clin Oncol. 2007 Mar 1;25(7):760-6
references.pmid: 17228019
references.citation: J Thorac Oncol. 2010 Jun;5(6):909-16
references.pmid: 20521358
references.citation: J Clin Oncol. 2008 Jul 20;26(21):3543-51
references.pmid: 18506025
references.citation: Br J Cancer. 2011 Oct 11;105(8):1123-30
references.pmid: 21934690
references.citation: J Clin Oncol. 2007 Dec 10;25(35):5570-7
references.pmid: 18065729
references.citation: Lung Cancer. 2003 May;40(2):221-6
references.pmid: 12711125
references.citation: J Thorac Oncol. 2008 Oct;3(10):1166-71
references.pmid: 18827614
references.citation: Chest. 2007 Sep;132(3 Suppl):277S-289S
references.pmid: 17873174
references.citation: J Clin Oncol. 2011 Sep 20;29(27):3636-42
references.pmid: 21709194
references.citation: Surg Today. 2013 May;43(5):514-20
references.pmid: 23124708
references.citation: Eur J Cancer. 2007 Oct;43(15):2161-9
references.pmid: 17855074
references.citation: J Thorac Oncol. 2007 Feb;2(2):141-6
references.pmid: 17410030
references.citation: J Thorac Oncol. 2010 Jan;5(1):82-9
references.pmid: 19884854
references.citation: J Am Coll Surg. 2007 Dec;205(6):729-34
references.pmid: 18035254
references.citation: Ann Thorac Surg. 2006 Oct;82(4):1175-9
references.pmid: 16996903
references.citation: J Thorac Oncol. 2007 Jun;2(6):494-8
references.pmid: 17545843
references.citation: J Clin Oncol. 2008 Oct 1;26(28):4617-25
references.pmid: 18678835