title: Aberrant expression of CXCR4 and β-catenin in pancreatic cancer.
abstract: OBJECTIVE
  The stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis and Wingless and INT-1 (Wnt)/β-catenin pathway has been related to cancer progression. The aim of this study was to investigate the expression of CXCR4 and β-catenin in pancreatic cancer.
  
  
  METHODS
  A total of 48 pancreatic cancer samples and 8 normal pancreatic tissues were selected to detect CXCR4 and β-catenin expression by an immunohistological technique. Spearman and Chi-square analyses were used to study the relation between the protein expression and clinical characteristics. Survival analysis was evaluated by the Kaplan-Meier product limit method.
  
  
  RESULTS
  The proportions of CXCR4 and β-catenin expression on pancreatic cancer cells were significantly higher than in normal pancreas tissues. There was a significant difference in CXRC4 expression levels, lymph node metastasis and TNM stage. Clinical Significance was observed for β-catenin expression and lymph node metastasis; Kaplan-Meier curves suggested that clinical prognosis is poor for patients expressing CXCR4. Multivariate analysis showed that CXCR4 expression was an independent prognostic factor for pancreatic cancer.
  
  
  CONCLUSIONS
  Both CXCR4 and β-catenin are abnormally expressed in pancreatic cancer. CXCR4 may be an important marker for pancreatic cancer progression.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, P.R. China. qyma56@mail.xjtu.edu.cn or xjxpx@189.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.forename: Huanchen
authors.initials: H
authors.lastname: Sha
authors.forename: Xuqi
authors.initials: X
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
mesh_terms: D000368:Aged; D001483:Base Sequence; D045744:Cell Line, Tumor; D017931:DNA Primers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D019718:Receptors, CXCR4 / Q000235:genetics*; D016019:Survival Analysis; D051176:beta Catenin / Q000235:genetics*
chemical_list: C527276:CXCR4 protein, human; D017931:DNA Primers; D019718:Receptors, CXCR4; D051176:beta Catenin
keywords: CXCR4; Pancreatic cancer; tumor progression; β-catenin