title: Layer-by-layer polymer coating on discrete particles of cubic lyotropic liquid crystalline dispersions (cubosomes).
abstract: Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers using a layer-by-layer (LbL) approach. The first layer consisted of a copolymer synthesized from methacrylic acid and oleoyl methacrylate for enhanced incorporation within the bilayer of the cubic nanostructure. Six additional layers of poly(L-lysine) and poly(methacrylic acid) were then sequentially added, followed by a washing procedure to remove polymer aggregates from the soft matter particles. Polymer buildup was monitored via microelectrophoresis, dynamic light scattering, and small-angle X-ray scattering. Polymer-coated cubosomes were observed with cryo-transmission electron microscopy. A potential application of the modified nanostructured particles presented in this study is to reduce the burst-release effect associated with drug-loaded cubosomes. The effectiveness of this approach was demonstrated through loading and release results from a model hydrophilic small molecule (fluorescein).
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, VIC 3010, Australia.
authors.forename: Chantelle D
authors.initials: CD
authors.lastname: Driever
authors.forename: Xavier
authors.initials: X
authors.lastname: Mulet
authors.forename: Lynne J
authors.initials: LJ
authors.lastname: Waddington
authors.forename: Almar
authors.initials: A
authors.lastname: Postma
authors.forename: Helmut
authors.initials: H
authors.lastname: Thissen
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
authors.forename: Calum J
authors.initials: CJ
authors.lastname: Drummond
mesh_terms: D003102:Colloids / Q000737:chemistry; D004573:Electrolytes / Q000138:chemical synthesis / Q000737:chemistry; D050866:Liquid Crystals / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003102:Colloids; D004573:Electrolytes; D011108:Polymers