title: Sex differences in the persistence of the amygdala response to negative material.
abstract: Previous studies have indicated that men and women have different amygdala responses to novel (vs familiar) and valenced (positive vs negative) material. It is not known, however, whether these affective sex differences are related. In this study, we tested whether women have more persistent amygdala responses to familiar, negative material than men do. During fMRI, male and female participants viewed evocative images that varied in novelty and valence. Women and men showed equivalent responses to novel negative material, but women showed a sustained amygdala response to familiar negative material relative to men, indicating that women's amygdala responses were more persistent over multiple repetitions of negative material. Individuals with more persistent amygdala responses also reported greater levels of negative effect. These findings have implications for sex differences in the incidence of affective disorders.
authors.affiliation: Department of Psychiatry, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129 and Department of Psychology, Northeastern University, Boston, MA 02115, USA andreano@nmr.mgh.harvard.edu.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Andreano
authors.affiliation: Department of Psychiatry, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129 and Department of Psychology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Dickerson
authors.affiliation: Department of Psychiatry, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129 and Department of Psychology, Northeastern University, Boston, MA 02115, USA Department of Psychiatry, Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129 and Department of Psychology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Lisa Feldman
authors.initials: LF
authors.lastname: Barrett
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000378:metabolism*; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D012044:Regression Analysis; D012737:Sex Factors; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: amygdala; habituation; sex
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