title: Role of Hepatocyte Paraffin 1 antigen in the course of colorectal carcinogenesis.
abstract: BACKGROUND
  Few studies have reported the expression of Hepatocyte Paraffin 1 (Hep Par 1) in colorectal carcinomas with contradictory results. Reported rate of expression ranged from 4-50%. Moreover, the correlation between Hep Par 1 expression and clinicopathological parameters has not been investigated. The objective of the present study was to investigate the role of CPS1 (using Hep Par 1) in colonic carcinogenesis and characterize carcinomas which express it.
  
  
  METHODS
  Comparative analysis was done between Hep Par 1 expression in normal colonic mucosa (n=10), adenomatous polyps (n=29) and sporadic adenocarcinoma (n=40) and was correlated with clinicopathologic parameters.
  
  
  RESULTS
  Normal colonic mucosa did not express Hep Par 1. In contrast, it was expressed in dysplastic glands and neoplastic cells of well-moderately differentiated non-mucinous adenocarcinomas. Hep Par 1 was found in 47.5% of colonic carcinomas, 41.7% of polyps with high grade dysplasia (HGD) and 23.5% of polyps with low grade dysplasia (LGD). Mean Hep Par-1 score, likewise, was highest in carcinoma, high in polyps with HGD and lowest in polyps with LGD. Hep Par 1 expression inversely correlated with some conventional prognostic parameters including tumour type, grade, lymph node metastasis and AJCC stage. It did not correlate with depth of invasion or lymphovascular invasion.
  
  
  CONCLUSIONS
  Hep Par 1 (i.e. CPS1) might play an active role in initiation of dysplasia and progression of multistep colorectal carcinogenesis. However, it seems that CPS1 is not involved in invasion and tumour spread. Conversely, it might be in the play of suppressing cancer progression. These findings could have both prognostic and therapeutic applications.
authors.affiliation: Department of Pathology, Faculty of Medicine, Ain Shams University Cairo, Egypt.
authors.forename: Riham M
authors.initials: RM
authors.lastname: Abu-Zeid
authors.forename: Rola M
authors.initials: RM
authors.lastname: Farid
keywords: Adenomatous polyp; Hep Par 1; colonic carcinoma; progression
references.citation: J Korean Med Sci. 2003 Dec;18(6):842-8
references.pmid: 14676441
references.citation: Am J Clin Pathol. 2002 Dec;118(6):911-21
references.pmid: 12472285
references.citation: Proteomics Clin Appl. 2009 Sep 14;3(11):1326
references.pmid: 20098637
references.citation: World J Hepatol. 2010 Sep 27;2(9):337-44
references.pmid: 21161018
references.citation: Mutat Res. 2004 Nov 2;555(1-2):107-19
references.pmid: 15476855
references.citation: Lab Invest. 2008 Jan;88(1):78-88
references.pmid: 18026163
references.citation: Clin Cancer Res. 2005 Sep 1;11(17):6162-70
references.pmid: 16144916
references.citation: Comp Biochem Physiol B Biochem Mol Biol. 1998 Mar;119(3):527-37
references.pmid: 9734336
references.citation: Pathology. 2002 Oct;34(5):423-6
references.pmid: 12408340
references.citation: Hepatol Res. 2001 Jul;20(3):312-319
references.pmid: 11404191
references.citation: Cancer Res. 2005 Oct 1;65(19):8604-7
references.pmid: 16204024
references.citation: Vet Pathol. 2001 Nov;38(6):636-43
references.pmid: 11732796
references.citation: Am J Clin Pathol. 2003 Mar;119(3):361-6
references.pmid: 12645337
references.citation: Am J Clin Pathol. 2009 Jul;132(1):80-5
references.pmid: 19864237
references.citation: Am J Clin Pathol. 2004 Nov;122(5):721-7
references.pmid: 15491968
references.citation: Am J Pathol. 1993 Oct;143(4):1050-4
references.pmid: 7692729
references.citation: Int J Gynecol Pathol. 2004 Jan;23(1):58-64
references.pmid: 14668552
references.citation: Gastroenterology Res. 2009 Oct;2(5):277-281
references.pmid: 27956971
references.citation: Am J Surg Pathol. 2003 Jul;27(7):952-9
references.pmid: 12826887
references.citation: Arch Pathol Lab Med. 2007 Nov;131(11):1648-54
references.pmid: 17979482
references.citation: Appl Immunohistochem Mol Morphol. 2006 Sep;14(3):266-72
references.pmid: 16932016