title: Progressive pulmonary hypertension: another criterion for expeditious renal transplantation.
abstract: The aim of this retrospective study was to compare the prevalence of pulmonary hypertension in a cohort of patients with end-stage renal disease (ESRD) prior to and following renal transplantation and to identify the possible risk factors. Of the 425 renal transplantations performed between 2001 and 2007, Doppler echocardiographic findings were available in 124. The echocardiographic data, collected both pre- and post-transplant, included the pulmonary artery pressure (PAP), ejection fraction and left ventricular hypertrophy. The data analyzed included age, gender, hypertension, diabetes, smoking status, along with blood urea, creatinine, glomerular filtration rate, hemoglobin, hemodialysis duration, urine albumin, arterio-venous access and body mass index (BMI). Chi-square test was used for discrete variables and ANOVA was used for continuous variables. Of the patients studied, males comprised 72%; the mean age was 43.3 ± 13.02 years; 87% were hypertensive, 30% were diabetic and 4% were smokers. Statistical analysis revealed a significant reduction of the PAP, irrespective of its severity, following renal transplantation (P <0.05). The PAP had no significant correlation with any of the parameters analyzed, with the exception of BMI (P <0.05). Our study suggests that the PAP gets reduced in patients with ESRD after renal transplantation.
authors.affiliation: Department of Nephrology, Madras Medical Mission, Chennai, India. yogesh_nvreddy@yahoo.com
authors.forename: Yogesh N V
authors.initials: YN
authors.lastname: Reddy
authors.forename: Deepika
authors.initials: D
authors.lastname: Lunawat
authors.forename: Georgi
authors.initials: G
authors.lastname: Abraham
authors.forename: Milly
authors.initials: M
authors.lastname: Matthew
authors.forename: Ajith
authors.initials: A
authors.lastname: Mullasari
authors.forename: Prethivee
authors.initials: P
authors.lastname: Nagarajan
authors.forename: Yuvaram N V
authors.initials: YN
authors.lastname: Reddy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015897:Comorbidity; D018450:Disease Progression; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult