title: Co(II) and Cd(II) complexes derived from heterocyclic Schiff-Bases: synthesis, structural characterisation, and biological activity.
abstract: New monomeric cobalt and cadmium complexes with Schiff-bases, namely, N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]furan-2-carbohydrazide (L¹) and N'-[(E)-(3-hydroxy-4-methoxyphenyl)methylidene]thiophene-2-carbohydrazide (L²) are reported. Schiff-base ligands L¹ and L² were derived from condensation of 3-hydroxy-4-methoxybenzaldehyde (iso-vanillin) with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide, respectively. Complexes of the general formula [M(L)₂]Cl₂ (where M = Co(II) or Cd(II), L = L¹ or L²) have been obtained from the reaction of the corresponding metal chloride with the ligands. The ligands and their metal complexes were characterised by spectroscopic methods (FTIR, UV-Vis, ¹H, and ¹³C NMR spectra), elemental analysis, metal content, magnetic measurement, and conductance. These studies revealed the formation of four-coordinate complexes in which the geometry about metal ion is tetrahedral. Biological activity of the ligands and their metal complexes against gram positive bacterial strain Bacillus (G+) and gram negative bacteria Pseudomonas (G-) revealed that the metal complexes become less resistive to the microbial activities as compared to the free ligands.
authors.affiliation: Department of Chemistry, College of Education, (Ibn Al-Haitham), University of Baghdad, P.O. Box 4150, Adhamiya, Baghdad, Iraq.
authors.forename: Riyadh M
authors.initials: RM
authors.lastname: Ahmed
authors.forename: Enaam I
authors.initials: EI
authors.lastname: Yousif
authors.forename: Mohamad J
authors.initials: MJ
authors.lastname: Al-Jeboori
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D002104:Cadmium / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines; C587767:N'-((3-hydroxy-4-methoxyphenyl)methylidene)furan-2-carbohydrazide; C587768:N'-((3-hydroxy-4-methoxyphenyl)methylidene)thiophene-2-carbohydrazide; D012545:Schiff Bases; D002104:Cadmium; D003035:Cobalt
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