title: Jumping translocation in a case of de novo infant acute myeloid leukemia.
abstract: An infant presented with fever and purulent discharge from the left ear, proptosis of the right eye, and hepatosplenomegaly. She was diagnosed with acute monoblastic leukemia on morphological and flowcytometric analysis of the bone marrow. Karyotyping showed a jumping translocation (JT) involving the long arm of chromosome 1 as the sole cytogenetic abnormality in 29 metaphases. The patient died within 2 months of diagnosis. The presence of JT in a de novo infant AML as a sole cytogenetic abnormality indicates its possible role in leukemogenesis unlike previous reports that have implicated its role in tumor progression only.
authors.affiliation: Department of Cytogenetics and Laboratory Hematology, Tata Medical Center, Kolkata, India.
authors.forename: Mayur
authors.initials: M
authors.lastname: Parihar
authors.forename: Anurag
authors.initials: A
authors.lastname: Gupta
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Yadav
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Mishra
authors.forename: Arpita
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: Mammen
authors.initials: M
authors.lastname: Chandy
mesh_terms: D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*
keywords: 1q; Jumping translocation; acute monoblastic leukemia; infant AML