title: A novel polyrotaxane-based delivery system for scutellarin: preparation, characterization, and in vitro evaluation.
abstract: The safe and effective polyrotaxane-based drug delivery system could potentially increase the antiproliferative activity of antitumor medicine. A novel scutellarin-polyrotaxane (SCU-PR), in which scutellarin (SCU) was covalently bound to one of the hydroxyl groups of polyrotaxane (PR), was synthesized, and its characterization was further investigated by NMR, XRD, TG, DSC. The cytotoxicity of SCU-PR was assessed in vitro using human HCT116 and LOVO cell lines in results that the IC50 values of SCU-PR (1.03×10(-6) and 1.01×10(-6)mol/L, respectively), which compared with those of free SCU (7.80×10(-5) and 7.70×10(-5)mol/L, respectively), were lower. The valuable properties of SCU-PR will be potentially useful for its application on human colon cancer chemotherapies.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors.forename: Rui-Jian
authors.initials: RJ
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Zhen-Kun
authors.initials: ZK
authors.lastname: Liu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhao
authors.forename: Xia-Li
authors.initials: XL
authors.lastname: Liao
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Chuan-Zhu
authors.initials: CZ
authors.lastname: Gao
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Han
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005965:Glucuronates / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D020442:Poloxamer / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D012449:Safety; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D005965:Glucuronates; D043862:Rotaxanes; C475673:polyrotaxane; D014867:Water; D020442:Poloxamer; C484876:scutellarin; D047310:Apigenin
keywords: Characterization; Cyclodextrin; Cytotoxicity; Polyrotaxane; Preparation; Scutellarin