title: Use of calcium caseinate in association with lecithin for masking the bitterness of acetaminophen--comparative study with sodium caseinate.
abstract: Owing to a variety of structural and functional properties, milk proteins are steadily studied for food and pharmaceutical applications. In the present study, calcium caseinate in association with lecithin was firstly investigated in order to encapsulate the acetaminophen through spray-drying for taste-masking purpose for pediatric medicines. A 2(4)-full factorial design revealed that the spray flow, the calcium caseinate amount and the lecithin amount had significant effects on the release of drug during the first 2 min. Indeed, increasing the spray flow and/or the calcium caseinate amount led to increase the released amount, whereas increasing the lecithin amount decreased the released amount. The "interaction" between the calcium caseinate amount and the lecithin amount was also shown to be statistically significant. The second objective was to compare the efficiency of two caseinate-based formulations, i.e. sodium caseinate and calcium caseinate, on the taste-masking effect. The characteristics of spray-dried powders determined by SEM and DSC were shown to depend on the caseinate/lecithin proportion rather than the type of caseinate. Interestingly, calcium caseinate-based formulations were found to lower the released amount of drug during the early time to a higher extent than sodium caseinate-based formulations, which indicates better taste-masking efficiency.
authors.affiliation: Université Lille Nord de France, College of Pharmacy, 3 rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France; INSERM U1008: Controlled Drug Delivery Systems and Biomaterials, 3 rue du Professeur Laguesse, 59006 Lille Cedex, France.
authors.forename: Thanh Huong
authors.initials: TH
authors.lastname: Hoang Thi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lemdani
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Flament
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry*; D002364:Caseins / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D054709:Lecithins / Q000008:administration & dosage / Q000737:chemistry*; D013649:Taste / Q000187:drug effects
chemical_list: D002364:Caseins; D004338:Drug Combinations; D054709:Lecithins; C484216:calcium caseinate; D000082:Acetaminophen
keywords: Calcium caseinate; Pediatric formulation; Sodium caseinate; Spray-drying; Taste-masking