title: [VEGF inhibitors in vitreoretinal interventions].
abstract: Vascular endothelial growth factor (VEGF) inhibitors are being used for an increasing number of indications. Beyond the classical use in exudative macular degeneration and macular edema, they are being used, for example off-label as additive treatment together with panretinal laser photocoagulation or in preparation for vitrectomy for ischemic retinopathy. In preparation for vitreoretinal surgery VEGF inhibitors are usually given prior to surgery. When given as an adjunct to laser treatment, VEGF inhibitors can be given either consecutively or parallel to laser photocoagulation. In most cases, however, anti-VEGF treatment does not render laser coagulation dispensable. The greatest danger with anti-VEGF treatment in the context of ischemic retinopathies lies in the fact that proliferative membranes are misjudged or overlooked. In these cases, anti-VEGF treatment can induce contraction of these membranes with induction of consecutive tractional retinal detachment. This review summarizes the current knowledge on VEGF inhibition as an adjunct to vitreoretinal surgery and also points out the gaps in the current knowledge and the need for further research.
authors.affiliation: Universitäts-Augenklinik, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland, nicolas.feltgen@med.uni-goettingen.de.
authors.forename: N
authors.initials: N
authors.lastname: Feltgen
authors.forename: A
authors.initials: A
authors.lastname: Stahl
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D006801:Humans; D058449:Intravitreal Injections; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011292:Premedication / Q000379:methods*; D012164:Retinal Diseases / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D057586:Vitreoretinal Surgery / Q000379:methods*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D009883:Ophthalmic Solutions; D042461:Vascular Endothelial Growth Factor A
references.citation: Ophthalmology. 2009 Oct;116(10):1943-8
references.pmid: 19699531
references.citation: Arch Ophthalmol. 1997 Apr;115(4):486-91
references.pmid: 9109757
references.citation: Ophthalmology. 2006 Oct;113(10):1695.e1-15
references.pmid: 17011951
references.citation: Ophthalmology. 1991 Oct;98(10):1575-9
references.pmid: 1961647
references.citation: Ophthalmology. 2006 Jan;113(1):23-8
references.pmid: 16343627
references.citation: Acta Ophthalmol. 2008 Jun;86(4):385-9
references.pmid: 17995982
references.citation: Ophthalmology. 2013 Oct;120(10):2013-22
references.pmid: 23706949
references.citation: Retina. 2013 May;33(5):957-63
references.pmid: 23503340
references.citation: Invest Ophthalmol Vis Sci. 2012 Jun 28;53(7):4323-8
references.pmid: 22661475
references.citation: Ophthalmologe. 2011 Nov;108(11):1062, 1064-6
references.pmid: 22090092
references.citation: Eur J Ophthalmol. 2008 Mar-Apr;18(2):263-9
references.pmid: 18320520
references.citation: JAMA Ophthalmol. 2013 Mar;131(3):283-93
references.pmid: 23370902
references.citation: J Biol Chem. 1999 Aug 27;274(35):25130-5
references.pmid: 10455194
references.citation: Dtsch Arztebl Int. 2010 Feb;107(5):75-83; quiz 84
references.pmid: 20186318
references.citation: Ophthalmology. 2012 Aug;119(8):1658-65
references.pmid: 22537617
references.citation: Arch Ophthalmol. 1984 Apr;102(4):520-6
references.pmid: 6367724
references.citation: Retina. 2009 Apr;29(4):516-22
references.pmid: 19262436
references.citation: Arch Ophthalmol. 1984 Apr;102(4):527-32
references.pmid: 6367725
references.citation: Ophthalmology. 1992 Sep;99(9):1351-7
references.pmid: 1407968
references.citation: Am J Ophthalmol. 2013 Jul;156(1):106-115.e2
references.pmid: 23791371
references.citation: Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10457-61
references.pmid: 7479819
references.citation: Retina. 2011 Jul-Aug;31(7):1254-60
references.pmid: 21499192
references.citation: Ophthalmology. 2013 Apr;120(4):795-802
references.pmid: 23260261
references.citation: Retina. 2010 May;30(5):781-6
references.pmid: 20464787
references.citation: Cytokine. 2012 Nov;60(2):535-9
references.pmid: 22846147
references.citation: Am J Physiol. 1998 Mar;274(3):H1054-8
references.pmid: 9530221
references.citation: Ophthalmology. 2011 Apr;118(4):636-41
references.pmid: 21055812
references.citation: Am J Ophthalmol. 1994 Oct 15;118(4):445-50
references.pmid: 7943121
references.citation: Am J Ophthalmol. 2008 Oct;146(4):508-12
references.pmid: 18635152
references.citation: Br J Ophthalmol. 2008 Feb;92(2):213-6
references.pmid: 17965108