title: Synthesis, biological activities and SAR studies of novel 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid based diacyl and sulfonyl acyl hydrazines.
abstract: BACKGROUND
  Diacyl hydrazines have attracted significant interest in medicine, pesticide chemistry and material science. It is an important class of insect growth regulators. In this study, acyl hydrazine, the essential active group was incorporated in to nalidixic acid with the aim of combining the active groups to generate more potent agrochemical.
  
  
  RESULTS
  Various nalidixic acid based diacyl and sulphonyl acyl hydrazines derivatives were synthesized and characterized by spectral techniques. These compounds were screened for the antifungal activity against five pathogenic fungi, nitrification inhibitory activity and insect growth regulator (IGR) activity against Spodoptera litura. The fungicidal activity was screened against R. bataticola, S. rolfsii, R. solani, F. oxysporum and A. porri. Most of the compounds showed moderate to good antifungal activity against A. porri (ED50 = 29.6-495.9 µg/mL). All the compounds showed significant nitrification inhibitory activity at 5% level. IGR activity was examined by feeding method against S. litura.
  
  
  CONCLUSIONS
  The study revealed that a few compounds possessed good activity against three different pests namely certain fungus, soil bacteria and insect, among which, compound 37 (R' = 4-chlorophenyl) behaved the best.
authors.affiliation: Division of Agricultural Chemicals, IARI, Pusa Campus, New Delhi, 110 012, India; Department of Chemistry, University of Delhi, New Delhi, 110 007, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Aggarwal
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Chitra
authors.initials: C
authors.lastname: Srivastava
authors.forename: Prem
authors.initials: P
authors.lastname: Dureja
authors.forename: J M
authors.initials: JM
authors.lastname: Khurana
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000494:pharmacology*; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000138:chemical synthesis / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D058465:Nitrification / Q000187:drug effects; D018411:Spodoptera / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D005659:Fungicides, Industrial; D006834:Hydrazines; D007605:Juvenile Hormones
keywords: acyl hydrazines; fungicidal activity; insect growth regulatory activity; nalidixic acid; nitrification inhibitory activity