title: [The synthesis of proteins in unnucleated blood platelets].
abstract: Platelets are the smallest, unnucleated blood cells that play a key role in maintaining normal hemostasis. In the human body about 1x1011 platelets are formed every day, as a the result of complex processes of differentiation, maturation and fragmentation of megakaryocytes. Studies done over 4 decades ago demonstrated that circulating in blood mature platelets can synthesize proteins. Recent discoveries confirm protein synthesis by unnucleated platelets in response to activation. Moreover, protein synthesis alters the phenotype and function of platelets. Platelets synthesize several proteins involved in hemostasis (COX, αIIbβ3, TF PAI-1, Factor XI, protein C inhibitor) and in inflammatory process (IL-1β, CCL5/RANTES). In spite of lack of transcription platelets have a stable mRNA transcripts with a long life correlated with platelet life span. Platelets also show expression of two important key regulators of translation eIF4E and EIF-2α and have a variety of miRNA molecules responsible for translational regulation. This article describes the historical overview of research on protein synthesis by platelets and presents the molecular mechanisms of protein synthesis in activated platelets (and synthesis of the most important platelet proteins).
authors.affiliation: Katedra Biochemii Ogólnej, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki.
authors.forename: Michał
authors.initials: M
authors.lastname: Bijak
authors.forename: Joanna
authors.initials: J
authors.lastname: Saluk
authors.forename: Michał Błażej Ponczek
authors.initials: MB
authors.lastname: Ponczek
authors.forename: Paweł
authors.initials: P
authors.lastname: Nowak
authors.forename: Barbara
authors.initials: B
authors.lastname: Wachowicz
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D015539:Platelet Activation; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger