title: Prognostic significance of six-minute walk test in non-group 1 pulmonary hypertension.
abstract: OBJECTIVE
  To assess the value of the six-minute walk test (6MWT) to predict outcome in non-group 1 pulmonary hypertension (PH).
  
  
  BACKGROUND
  Distance walked during 6MWT has been widely used as a prognostic test in pulmonary arterial hypertension (group 1 pulmonary hypertension); however, little is known regarding its prognostic value in other groups of PH.
  
  
  METHODS
  This was a retrospective study of 60 patients diagnosed of PH, Dana Point classification groups 2-5. 6MWT and echocardiography were performed in all cases.
  
  
  RESULTS
  Forty patients (66.6%) were females. Mean age was 70.8 ± 10.7 years (range: 32-85). Seven patients died after a mean follow-up of 23.2 ± 16.7 months. Distance <400 m during 6MWT was associated with a higher risk for death (RR: 4.39; 95% CI: 1.13-17.05; p = 0.03) and for clinical deterioration (death or need for hospitalization) (RR: 2.76; 95% CI: 1.18-6.42; p = 0.02).
  
  
  CONCLUSIONS
  6MWT is useful to predict outcome in non-group 1 PH.
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain. Electronic address: rafael.golpe.gomez@sergas.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Golpe
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Olalla
authors.initials: O
authors.lastname: Castro-Añón
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Pérez-de-Llano
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Juanatey
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Camino
authors.initials: C
authors.lastname: Muñiz-Fernández
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Testa-Fernández
authors.affiliation: Respiratory Medicine Service and the Cardiology Service, Hospital Universitario Lucus Augusti, Lugo, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Pérez-Fernández
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000401:mortality; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
keywords: 6MWT; 95% CI; 95% confidence interval; CI; COPD; CT90; CTPEH; Echocardiography; Exercise test; Hypertension; IVC; LVSF; Mortality; OPD; PAH; PH; Prognosis; Pulmonary; RR; RV; RVSF; SDB; SPAP; SaO(2); TAPSE; arterial oxygen saturation; chronic obstructive pulmonary disease; chronic thromboembolic pulmonary hypertension; confidence intervals; cumulative percentages of time at SaO(2) below 90%; inferior vena cava; left ventricle systolic function; other pulmonary diseases with mixed obstructive and restrictive pattern; pulmonary artery hypertension; pulmonary hypertension; relative risk; right ventricle; right ventricle systolic function; six-minute walk test; sleep disordered-breathing; systolic pulmonary artery pressure; tricuspid annular plane systolic excursion