title: Bacteriocins - exploring alternatives to antibiotics in mastitis treatment.
abstract: Mastitis is considered to be the most costly disease affecting the dairy industry. Management strategies involve the extensive use of antibiotics to treat and prevent this disease. Prophylactic dosages of antibiotics used in mastitis control programmes could select for strains with resistance to antibiotics. In addition, a strong drive towards reducing antibiotic residues in animal food products has lead to research in finding alternative antimicrobial agents. In this review we have focus on the pathogenesis of the mastitis in dairy cows, existing antibiotic treatments and possible alternative for application of bacteriocins from lactic acid bacteria in the treatment and prevention of this disease.
authors.affiliation: 1Department of Microbiology, University of Stellenbosch, , 7600 Stellenbosch , South Africa;
authors.forename: Reneé
authors.initials: R
authors.lastname: Pieterse
authors.forename: Svetoslav D
authors.initials: SD
authors.lastname: Todorov
keywords: antibiotic; bacteriocin; food safety; mastitis; milk
references.citation: Vet Microbiol. 2005 Mar 20;106(1-2):61-71
references.pmid: 15737474
references.citation: J Bacteriol. 1947 Dec;54(6):785-92
references.pmid: 16561421
references.citation: J Mol Microbiol Biotechnol. 2002 Jul;4(4):347-55
references.pmid: 12125815
references.citation: Can J Vet Res. 1987 Jan;51(1):27-31
references.pmid: 3552170
references.citation: Reproduction. 2004 Jul;128(1):117-26
references.pmid: 15232069
references.citation: Int J Food Microbiol. 2004 Dec 15;97(2):215-9
references.pmid: 15541808
references.citation: J Am Vet Med Assoc. 1980 May 15;176(10 Spec No):1109-15
references.pmid: 7216882
references.citation: Avian Dis. 1999 Apr-Jun;43(2):245-50
references.pmid: 10396637
references.citation: Arch Microbiol. 1994;161(3):199-206
references.pmid: 8161282
references.citation: J Dairy Sci. 2002 Oct;85(10):2512-20
references.pmid: 12416803
references.citation: Nat Rev Microbiol. 2005 Oct;3(10):777-88
references.pmid: 16205711
references.citation: Appl Environ Microbiol. 2002 Dec;68(12):5891-903
references.pmid: 12450808
references.citation: Appl Environ Microbiol. 2001 Feb;67(2):569-74
references.pmid: 11157218
references.citation: Antimicrob Agents Chemother. 2000 Jan;44(1):24-9
references.pmid: 10602718
references.citation: Int J Syst Bacteriol. 1998 Apr;48 Pt 2:519-27
references.pmid: 9731293
references.citation: J Bacteriol. 1928 Nov;16(5):321-5
references.pmid: 16559344
references.citation: Eur J Biochem. 1988 Oct 15;177(1):53-9
references.pmid: 3181159
references.citation: Adv Drug Deliv Rev. 2001 Sep 1;50(3):245-59
references.pmid: 11500230
references.citation: J Dairy Sci. 1988 Sep;71(9):2584-606
references.pmid: 3053815
references.citation: J S Afr Vet Assoc. 2000 Sep;71(3):201-8
references.pmid: 11205172
references.citation: Antimicrob Agents Chemother. 1985 May;27(5):841-5
references.pmid: 4015074
references.citation: Nat Rev Microbiol. 2004 May;2(5):425-30
references.pmid: 15100695
references.citation: Bacteriol Rev. 1976 Sep;40(3):722-56
references.pmid: 791239
references.citation: J Antimicrob Chemother. 1998 Aug;42(2):277-8
references.pmid: 9738856
references.citation: J Dairy Sci. 1998 Mar;81(3):678-86
references.pmid: 9565870
references.citation: Microbiology (Reading). 2002 Nov;148(Pt 11):3347-3352
references.pmid: 12427926
references.citation: Appl Environ Microbiol. 1998 Jun;64(6):2287-90
references.pmid: 9603853
references.citation: Vet Rec. 2001 Jun 2;148(22):683-6
references.pmid: 11425254
references.citation: Curr Pharm Des. 2005;11(8):1067-75
references.pmid: 15777256
references.citation: J Antimicrob Chemother. 2005 Nov;56(5):869-71
references.pmid: 16155061
references.citation: J Dairy Sci. 2000 Sep;83(9):1981-8
references.pmid: 11003227
references.citation: J Food Prot. 1995 Sep;58(9):977-983
references.pmid: 31137421
references.citation: Appl Environ Microbiol. 1998 Feb;64(2):439-45
references.pmid: 9464377
references.citation: J Dairy Sci. 1992 Nov;75(11):3185-90
references.pmid: 1460143
references.citation: Zh Mikrobiol Epidemiol Immunobiol. 2004 Jul-Aug;(4):17-20
references.pmid: 15481913
references.citation: Int J Food Microbiol. 1998 Jul 21;42(3):147-58
references.pmid: 9728685
references.citation: J Dairy Res. 2005 May;72(2):159-67
references.pmid: 15909681
references.citation: Int J Syst Evol Microbiol. 2002 May;52(Pt 3):945-951
references.pmid: 12054262
references.citation: J Dairy Sci. 1995 Jun;78(6):1310-7
references.pmid: 7673520
references.citation: FEMS Microbiol Lett. 2001 Nov 13;204(2):329-34
references.pmid: 11731144
references.citation: Vet Microbiol. 2003 Apr 2;92(3):245-52
references.pmid: 12523986
references.citation: Vet Microbiol. 2000 Jun 12;74(4):331-43
references.pmid: 10831855
references.citation: Ann Inst Pasteur (Paris). 1953 Jan;84(1):222-4
references.pmid: 13031254
references.citation: Eur J Biochem. 1986 Oct 1;160(1):9-22
references.pmid: 3769923
references.citation: Int J Syst Bacteriol. 1999 Apr;49 Pt 2:759-67
references.pmid: 10319500
references.citation: Vet J. 2006 May;171(3):398-407
references.pmid: 16624706
references.citation: Microb Pathog. 2006 Jun;40(6):279-85
references.pmid: 16678381
references.citation: J Dairy Sci. 1992 Feb;75(2):596-605
references.pmid: 1560148
references.citation: FEMS Microbiol Rev. 1993 Sep;12(1-3):39-85
references.pmid: 8398217
references.citation: Appl Environ Microbiol. 2000 Oct;66(10):4595-7
references.pmid: 11010926
references.citation: Microbiol Rev. 1995 Jun;59(2):171-200
references.pmid: 7603408
references.citation: Biotechnology. 1995;28:307-21
references.pmid: 8688629
references.citation: Appl Environ Microbiol. 1996 Feb;62(2):612-9
references.pmid: 8593062
references.citation: Int J Food Microbiol. 2003 Aug 15;85(1-2):23-33
references.pmid: 12810268
references.citation: Meat Sci. 2000 Nov;56(3):215-9
references.pmid: 22062071
references.citation: Vet J. 2002 Sep;164(2):116-28
references.pmid: 12359466
references.citation: J Med Microbiol. 2003 Sep;52(Pt 9):829-833
references.pmid: 12909662
references.citation: J S Afr Vet Assoc. 2006 Jun;77(2):52-60
references.pmid: 17120619
references.citation: J Biol Chem. 1997 May 30;272(22):14277-84
references.pmid: 9162062
references.citation: Int J Food Microbiol. 2006 Mar 15;107(2):138-47
references.pmid: 16288813
references.citation: Indian J Med Res. 2004 May;119 Suppl:13-6
references.pmid: 15232154
references.citation: Domest Anim Endocrinol. 2005 Aug;29(2):283-93
references.pmid: 15950428
references.citation: Lancet. 1997 Feb 8;349(9049):418-22
references.pmid: 9033483
references.citation: Appl Environ Microbiol. 2006 Feb;72(2):1148-56
references.pmid: 16461661
references.citation: J Dairy Sci. 2003 Oct;86(10):3068-74
references.pmid: 14594223
references.citation: Vestn Dermatol Venerol. 1989;(6):62-4
references.pmid: 2686265
references.citation: Mol Microbiol. 2006 Jul;61(2):285-96
references.pmid: 16771847