title: Efficacy of a new mouth rinse formulation based on 0.07% cetylpyridinium chloride in the control of plaque and gingivitis: a 6-month randomized clinical trial.
abstract: OBJECTIVE
  To assess the efficacy of a 0.07% cetylpyridinium chloride (CPC) mouth rinse in the control of plaque and gingival inflammation during a 6-month period.
  
  
  METHODS
  Adult subjects with moderate gingivitis were selected [≥40% bleeding on marginal probing (BOMP)]. After retrieving microbiological samples and evaluating the clinical parameters (plaque, BOMP and stain indexes), a professional prophylaxis was performed and subjects were randomly assigned to the test (CPC mouth rinse) or to the placebo group. Subjects were re-assessed after 3 and 6 months.
  
  
  RESULTS
  A total of 67 patients (35 test, 32 placebo) were included in the analysis. At 6 months, intra-group significant plaque reductions were observed in the test group (0.691, p < 0.001), but not in the placebo (0.181, p = 0.653). At 6 months, the mean BOMP values were lower in the test group (p = 0.052). Changes between baseline and 6 months were significantly higher in the test group both for plaque (p = 0.002) and BOMP (p = 0.037) when compared with the placebo. A microbiological impact was observed in the test group, especially for Prevotella intermedia.
  
  
  CONCLUSIONS
  The evaluated 0.07% CPC-based mouth rinse, used three times per day adjunctively to mechanical tooth cleaning, prevents plaque accumulation and gingival inflammation, as compared to the placebo, for at least 6 months.
authors.affiliation: Section of Graduate Periodontology - Faculty of Odontology, University Complutense, Madrid, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Costa
authors.forename: Estefanía
authors.initials: E
authors.lastname: Laguna
authors.forename: David
authors.initials: D
authors.lastname: Herrera
authors.forename: Jorge
authors.initials: J
authors.lastname: Serrano
authors.forename: Bettina
authors.initials: B
authors.lastname: Alonso
authors.forename: Mariano
authors.initials: M
authors.lastname: Sanz
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects; D002206:Capnocytophaga / Q000187:drug effects; D002594:Cetylpyridinium / Q000737:chemistry / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D004311:Double-Blind Method; D016124:Eikenella corrodens / Q000187:drug effects; D005051:Eubacterium / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D016967:Fusobacterium nucleatum / Q000187:drug effects; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010462:Peptostreptococcus / Q000187:drug effects; D010919:Placebos; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D045242:Prevotella nigrescens / Q000187:drug effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; D002594:Cetylpyridinium
keywords: antiseptics; cetylpyridinium chloride; dental plaque; gingivitis; mouth rinse