title: A 52-year-old-male patient with metastatic non-small-cell lung cancer and recurrent venous thromboembolism in unusual sites despite anticoagulation.
abstract: The link between cancer and venous thromboembolism is well known, with an annual incidence rate of venous thromboembolism between 0.5% and 20% depending on the primary site and background risk factors. Current guidelines suggest treatment with low-molecular-weight heparin over oral vitamin K antagonists. However, data regarding the management of recurrent venous thromboembolism when the patient is under treatment with anticoagulants are sparse. In this article we present a patient with multiple thromboembolic events in unusual sites despite anticoagulant treatment and we discuss the management options.
authors.affiliation: Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
authors.forename: Alexios
authors.initials: A
authors.lastname: Matikas
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Vardakis
authors.forename: John
authors.initials: J
authors.lastname: Souglakos
authors.forename: Vassilios
authors.initials: V
authors.lastname: Georgoulias
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary*; D017809:Fatal Outcome; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007601:Jugular Veins; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D017538:Mesenteric Artery, Superior; D008641:Mesenteric Vascular Occlusion / Q000209:etiology / Q000517:prevention & control; D008875:Middle Aged; D055502:Secondary Prevention; D013350:Subclavian Vein; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D000078222:Tinzaparin; D017211:Treatment Failure; D054556:Venous Thromboembolism / Q000209:etiology / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin
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