title: Tandem reaction of 1-copper(I) alkynes for the synthesis of 1,4,5-trisubstituted 5-chloro-1,2,3-triazoles.
abstract: A novel tandem reaction of 1-copper(I) alkynes with azides (cycloaddition) and then NCS (electrophilic substitution) was developed as an efficient method for the synthesis of 1,4,5-trisubstituted 5-chloro-1,2,3-triazoles. The method offers a rare example that a tandem reaction of an organometallic substrate does not involve in the reactivity of the metal-carbon bond in the first step.
authors.affiliation: Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Jianlan
authors.initials: J
authors.lastname: Zhang
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Liu
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu