title: Studies on organophosphorus compounds. Part 1: synthesis and in vitro antimicrobial activity of some new pyrimido[5',4':5,6]pyrano[2,3-d][1,3,2]thiazaphosphinine compounds.
abstract: 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent, LR) reacted with pyrano[2,3-d]pyrimidine-2,4-(1H,3H)-dione derivatives in boiling acetonitrile to afford various pyrimido[5',4':5,6]pyrano[2,3-d][1,3,2]thiazaphosphinine derivatives. The structures of the target compounds were characterized by elemental analysis and spectral data. The biological activities of all synthesized compounds were tested against various microorganisms by the disk diffusion method. In general, the newly synthesized compounds showed good inhibitory effects against most of the applied microorganisms.
authors.affiliation: Faculty of Science, Department of Chemistry, Sohag University, Sohag, Egypt.
authors.forename: Sabry H H
authors.initials: SH
authors.lastname: Younes
authors.forename: Shaaban K
authors.initials: SK
authors.lastname: Mohamed
authors.forename: Mustafa R
authors.initials: MR
authors.lastname: Albayati
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis; D018675:Toxicity Tests
chemical_list: D000890:Anti-Infective Agents; D001555:Benzene Derivatives; D009943:Organophosphorus Compounds; C519090:phosphinine
keywords: Barbituric acids; Biological activity; Lawesson's reagent; Organophosphorous compounds