title: Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.
abstract: Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantum yield in water (ΦΔ > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 μM).
authors.affiliation: Department of Chemistry, Kuwait University, P.O. Box 5969, Safat, 13060, Kuwait. saad.makhseed@ku.edu.kw.
authors.forename: Saad
authors.initials: S
authors.lastname: Makhseed
authors.forename: Miloslav
authors.initials: M
authors.lastname: Machacek
authors.forename: Waleed
authors.initials: W
authors.lastname: Alfadly
authors.forename: Ahmad
authors.initials: A
authors.lastname: Tuhl
authors.forename: Mickey
authors.initials: M
authors.lastname: Vinodh
authors.forename: Tomas
authors.initials: T
authors.lastname: Simunek
authors.forename: Veronika
authors.initials: V
authors.lastname: Novakova
authors.forename: Pavel
authors.initials: P
authors.lastname: Kubat
authors.forename: Emil
authors.initials: E
authors.lastname: Rudolf
authors.forename: Petr
authors.initials: P
authors.lastname: Zimcik
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D054833:Isoindoles; D051379:Mice; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011789:Quantum Theory; D026082:Singlet Oxygen / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry*; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; D014867:Water; C052159:Zn(II)-phthalocyanine; D026082:Singlet Oxygen