title: Effect of delayed autologous breast reconstruction on breast cancer recurrence and survival.
abstract: BACKGROUND
  The goal of the present study was to evaluate the impact of delayed autologous breast reconstruction on disease relapse in breast cancer patients treated with mastectomy.
  
  
  METHODS
  The study was based on 503 consecutive patients younger than 70 years of age who underwent mastectomy between January 2000 and December 2003. Overall, 391 (78 %) received mastectomy alone and 112 (22 %) underwent a delayed breast reconstruction. The median time from mastectomy to delayed breast reconstruction was 34 months. The median duration of follow-up was 102 months.
  
  
  RESULTS
  There were no locoregional recurrences (LRR) in patients who underwent delayed reconstruction (0.0 %); 21 LRR developed in patients treated with mastectomy only (5.4 %), P = 0.011. Distant metastases occurred less frequently in the reconstruction group (12.5 %) than in the patients who underwent mastectomy alone (21.5 %); P = 0.0343. The 8-year breast cancer specific survival in the reconstruction group was 98.2 and 85.7 % for the mastectomy only group, P = 0.000.
  
  
  CONCLUSIONS
  Delayed autologous breast reconstruction does not appear to adversely influence disease progression when compared to patients treated with mastectomy only.
authors.affiliation: Department of Plastic Surgery, Töölö Hospital, Helsinki University Central Hospital, PO Box 266, 00029, HUS Helsinki, Finland, andrew.lindford@hus.fi.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lindford
authors.forename: Elina T
authors.initials: ET
authors.lastname: Siponen
authors.forename: Tiina A
authors.initials: TA
authors.lastname: Jahkola
authors.forename: Marjut H K
authors.initials: MH
authors.lastname: Leidenius
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D013524:Surgical Flaps; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
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