title: Different associations of adipokines in lean and healthy adults.
abstract: Regulation of adipokines in lean adults without metabolic disease and without eating disorders has not been comprehensively elucidated. We hypothesized that some of the established associations of these adipocyte-secreted proteins with anthropometric and biochemical measures of glucose homeostasis, lipid metabolism, renal function, as well as inflammation, differ in healthy and low weight adults as compared to overweight/obese patients. Eighty-one subjects with a body mass-index below 22.0 kg/m2 and without malnutrition or eating disorders, as well as fifty overweight/obese patients, were recruited for the study. Serum concentrations of seven adipokines (adiponectin, leptin, adipocyte fatty acid-binding protein [AFABP], chemerin, fibroblast growth factor [FGF]-21, resistin, retinol-binding protein [RBP]-4) were measured by enzyme-linked immunosorbent assays. Lean probands had significantly higher levels of adiponectin and resistin, as well as lower levels of leptin, AFABP, and RBP-4, as compared to overweight/obese subjects. Serum concentrations of adiponectin, leptin, AFABP, chemerin, and resistin were significantly higher in lean women as compared to men (p<0.05). In lean subjects, fasting insulin independently predicted leptin and resistin concentrations. Furthermore, C-reactive protein was independently associated with circulating AFABP and chemerin. Moreover, lean body mass was an independent predictor of leptin, fat mass predicted AFABP levels, whereas RBP-4 was independently correlated to age and triglycerides. In addition, high density lipoprotein cholesterol predicted AFABP. Our results support the notion that several of these adipokines are regulated in a different manner in lean adults as compared to overweight/obese subjects and patients with eating disorders.
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Ebert
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Roth
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Richter
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Tönjes
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Lossner
authors.affiliation: Institute of Laboratory Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Blüher
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D013851:Thinness / Q000097:blood*
chemical_list: D054392:Adipokines