title: Optical coherence tomography findings in spinocerebellar ataxia-3.
abstract: OBJECTIVE
  To report optical coherence tomography (OCT) findings in order to detect subclinical alterations of the afferent visual pathways in spinocerebellar ataxia 3 (SCA-3).
  
  
  METHODS
  Nine genetically confirmed patients (18 eyes) were evaluated with a complete ophthalmologic examination including visual acuity, colour vision, visual field test, and retinal nerve fibre layer (RNFL) and macular thickness with OCT Cirrus HD. A neurological examination was performed and the Scale for the Assessment and Rating of Ataxia (SARA score) was determined in all patients.
  
  
  RESULTS
  The mean RNFL thickness was 77.39 microns, standard deviation (SD) was ± 5.93. In 15 eyes (83.33%), the mean RNFL thickness was lower than the population average considering age and sex. In 10 cases, there was a reduction of the RNFL thickness in the superior sector, eight in the inferior and four in the nasal. Temporal sector RNFL thickness was preserved in all eyes. RNFL thickness was inversely correlated to SARA score (r=-0.64, P=0.012). The mean macular thickness was 252.61 microns, SD ± 22.80, being inferior respecting average population in only two eyes (11.11%). In four patients, (eight eyes) OCT studies were performed during a mean follow-up of 14.25 months, and in five eyes (62.50%) there was a mild trend to a RNFL thickness decrease in this period.
  
  
  CONCLUSIONS
  A mild and progressive decrease in RNFL thickness can be observed in SCA-3 patients. A negative correlation exists between an anatomic marker (RNFL thickness) and a clinical severity scale (SARA score); thus, RNFL thickness could be considered as a promising biomarker of the disease.
authors.affiliation: Department of Ophthalmology, Hospital Clinic de Barcelona, Calle Sabino de Arana, Barcelona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Alvarez
authors.affiliation: Department of Ophthalmology, Hospital Clinic de Barcelona, Calle Sabino de Arana, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rey
authors.affiliation: Department of Ophthalmology, Hospital Clinic de Barcelona, Calle Sabino de Arana, Barcelona, Spain.
authors.forename: F B
authors.initials: FB
authors.lastname: Sanchez-Dalmau
authors.affiliation: Department of Neurology, Hospital Clínic i Provincial de Barcelona, Calle Villarroel, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Muñoz
authors.affiliation: Laboratory of Biostatistics and Epidemiology, Hospital Clínic de Barcelona, calle Villarroel, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ríos
authors.affiliation: Department of Ophthalmology, Hospital Clinic de Barcelona, Calle Sabino de Arana, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Adán
mesh_terms: D000328:Adult; D055253:Color Vision / Q000502:physiology; D005260:Female; D006801:Humans; D017827:Machado-Joseph Disease / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D015835:Ocular Motility Disorders / Q000175:diagnosis*; D012164:Retinal Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014795:Visual Pathways / Q000473:pathology*
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