title: Anticataleptic effects of 5-HT(1B) receptors in the globus pallidus.
abstract: The globus pallidus occupies an important position in the indirect pathway of the basal ganglia. Being a monoamine neurotransmitter, 5-HT is involved in mediating many physiological functions and pathophysiological processes in several movement disorders. Morphological studies have revealed that the globus pallidus receives serotonergic innervation arising from the raphe nuclei, mainly the dorsal raphe nucleus. A high level of 5-HT and 5-HT(1B) receptors were detected in the globus pallidus. In the present study, bilateral microinjection of 5-HT or 5-HT(1B) receptor agonist, CP-93129, into the globus pallidus significantly alleviated the symptoms of rigidity caused by haloperidol. To further elucidate 5-HT(1B) receptor-induced anticatalepsy, in vivo extracellular recordings were performed to examine the effects of 5-HT(1B) receptor activation on the firing activity of the globus pallidus neurons under the presence of haloperidol. Micro-pressure ejection of 5-HT or CP-93129 increased the spontaneous firing rate of the pallidal neurons. Furthermore, by using immunohistochemistry, positive staining of 5-HT(1B) receptor was observed in the globus pallidus neurons. Taken together, the present findings provide evidence that activation of 5-HT(1B) receptor may exert anticataleptic effects by increasing the activity of pallidal neurons.
authors.affiliation: Department of Physiology, Qingdao University, Qingdao 266071, China; Department of Physiology, Binzhou Medical University, Yantai 264003, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Chen
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Xue
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D006220:Haloperidol / Q000633:toxicity; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D044302:Receptor, Serotonin, 5-HT1B / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
chemical_list: D011725:Pyridines; D011758:Pyrroles; D044302:Receptor, Serotonin, 5-HT1B; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists; C065046:3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one; D012701:Serotonin; D006220:Haloperidol
keywords: 5-HT(1B) receptor; Globus pallidus; Immunohistochemistry; Single unit recording