title: FDG PET in the evaluation of phaeochromocytoma: a correlative study with MIBG scintigraphy and Ki-67 proliferative index.
abstract: To compare 123I-metaiodobenzylguanidine (MIBG) and [Fluorine-18]-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in 22 patients with phaeochromocytomas and paragangliomas (PGL) retrospectively and to evaluate the correlation between FDG uptake and Ki-67 proliferative index. Fourteen of 17 (82%) patients at initial diagnosis had positive FDG uptake, more intensely in PGL. Eleven of 12 (92%) patients had positive MIBG uptake. PET and MIBG scintigraphy were concordant in 10 patients, discordant in 6. Combined results yielded no false negative findings and are complementary. Neither maximum standardised uptake value nor visual scores on MIBG correlated with Ki-67.
authors.affiliation: University of New South Wales, Liverpool Hospital, Liverpool, New South Wales 2170, Australia; Department of Nuclear Medicine and PET, Liverpool Hospital, Liverpool, New South Wales 2170, Australia. Electronic address: michael.lin@swsahs.nsw.gov.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Lin
authors.forename: Vincent
authors.initials: V
authors.lastname: Wong
authors.forename: June
authors.initials: J
authors.lastname: Yap
authors.forename: Richard
authors.initials: R
authors.lastname: Jin
authors.forename: Paul
authors.initials: P
authors.lastname: Leong
authors.forename: Peter
authors.initials: P
authors.lastname: Campbell
mesh_terms: D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D049109:Cell Proliferation; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000000981:diagnostic imaging / Q000473:pathology; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D019394:Ki-67 Antigen; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine
keywords: FDG; Ki-67 index; PET; Paraganglioma; Phaeochromocytoma