title: Discontinued drugs for pulmonary, allergy, gastrointestinal, arthritis (2012).
abstract: BACKGROUND
  Various compounds are developed to interfere with pathogenic pathways involved in inflammation processes. Some of them are able to enter the clinical development for different diseases with a common pathogenic denominator such as, for example, rheumatoid arthritis and chronic obstructive pulmonary disease (COPD), based on the preclinical evidence, but not all these molecules prove to be efficacious while tested in different phases of clinical development.
  
  
  METHODS
  This review discusses about the drugs that were discontinued from further development for pulmonary, allergy, gastrointestinal and arthritis diseases
  
  
  CONCLUSIONS
  Most of the drugs discontinued during 2012 were compounds with anti-inflammatory activity which were mostly designed to treat arthritis/rheumatoid arthritis. Some of these molecules were also intended for COPD. Many of them failed the late phases of the clinical development.
authors.affiliation: University of Medicine and Pharmacy, Department of Interdisciplinarity-Palliative Care Nursing , Grigore T Popa Iasi, 16 Universitatii Str, Iasi 700115 , Romania Sabina.antonela.antoniu@pneum.umfiasi.ro.
authors.forename: Sabina Antonela
authors.initials: SA
authors.lastname: Antoniu
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy; D055808:Drug Discovery / Q000639:trends; D015507:Drugs, Investigational / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D015507:Drugs, Investigational; D005765:Gastrointestinal Agents