title: [Morpho-functional characteristics of human spleen (an immunohistochemical study)].
abstract: Using immunohistochemical and morphometric methods, the quantitative composition and structural localization of immunocompetent cells were studied in human spleen (n=20, autopsy material). The detailed morpho-functional characteristics of splenic white and red pulp are presented. Cell subpopulations of T (CD3+, CD4+, CD8+) and B lymphocytes (CD20+), natural killer cells (CD57+), tissue macrophages (CD68+) and dendritic cells (CD35+, S100+) were studied. An analysis of the correlations of immunocompetent cells in different regions of white and red pulp may become the basis for optimization of histopathological diagnosis definition in clinical practice
authors.affiliation: State Medical Academy, Kirov, Russia
authors.forename: V B
authors.initials: VB
authors.lastname: Zaitsev
authors.forename: N S
authors.initials: NS
authors.lastname: Fedorovskaya
authors.forename: D A
authors.initials: DA
authors.lastname: Diakonov
authors.forename: A M
authors.initials: AM
authors.lastname: Fedorovskiy
authors.forename: L B
authors.initials: LB
authors.lastname: Dorokh
authors.forename: Ye V
authors.initials: YV
authors.lastname: Koledayeva
authors.forename: I N
authors.initials: IN
authors.lastname: Gamulinskaya
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000737:chemistry; D003713:Dendritic Cells / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural / Q000737:chemistry; D008264:Macrophages / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000737:chemistry / Q000166:cytology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry
chemical_list: D015703:Antigens, CD