title: Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester.
abstract: This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days and the propolis for the last 5 days with L-NAME together. The levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyltransferase in the L-NAME group compared to control group have increased (P&lt;0.05). The levels of these parameters in L-NAME+propolis group compared to the L-NAME group have decreased (P&lt;0.05). L-NAME caused increase (P&lt;0.05) in levels of glucose, albumin, globulin, creatinine, urea, triglyceride and cholesterol. Erythrocyte number, total leukocyte, hemoglobin, hematocrit, neutrophil and monocyte decreased (P&lt;0.05), platelets and lymphocyte increased (P&lt;0.05) in L-NAME+propolis group compared to the L-NAME group. The study concluded that homeostasis is modulated in L-NAME administrated rats by adding propolis which causes increasing generation of vascular nitric oxide.
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, Nigde University, Nigde, Turkey.
authors.forename: Zeliha Selamoglu
authors.initials: ZS
authors.lastname: Talas
authors.forename: Ayse
authors.initials: A
authors.lastname: Gogebakan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Orun
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism; D001774:Blood Chemical Analysis; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004906:Erythrocyte Count; D007958:Leukocyte Count; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011429:Propolis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D011429:Propolis; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester