title: Metabolic syndrome and functional ability in older age: the InCHIANTI study.
abstract: OBJECTIVE
  Metabolic syndrome (MetS) is associated with incident disability in middle-aged subjects. We evaluated the association of MetS with functional ability in an older population.
  
  
  METHODS
  We enrolled 1155 participants aged 65+, derived from the InCHIANTI study, and followed for 3 years. MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. Functional ability was estimated using the Katz's activities of daily living (ADLs), and the Lawton and Brody for the instrumental activities of daily living (IADLs) scales. The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.
  
  
  RESULTS
  At baseline, MetS was associated with reduced probability of ADLs disability among participants aged 74+ (OR = .33, 95% CI = .14-.77; p = .010), but not in younger (5.08, 95% CI = .88-29.24; p = .069). Also, MetS was associated with reduced probability of incident ADLs disability (OR = .61, 95% CI .41-.91; p = .016), but neither with prevalent, nor incident IADLs disability.
  
  
  CONCLUSIONS
  In older persons, MetS is associated with reduced probability of prevalent and incident ADLs disability. Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation.
authors.affiliation: Area di Geriatria, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy. Electronic address: lavoralice@gmail.com.
authors.forename: Alice
authors.initials: A
authors.lastname: Laudisio
authors.affiliation: Geriatric Rehabilitation Unit, Azienda Sanitaria di Firenze, Florence, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.affiliation: UOS Accesso e Presa in Carico Assistenziale, Azienda Sanitaria Locale Roma E, Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Gemma
authors.affiliation: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Area di Geriatria, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy.
authors.forename: Raffaele Antonelli
authors.initials: RA
authors.lastname: Incalzi
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D015999:Multivariate Analysis; D015995:Prevalence; D011446:Prospective Studies
keywords: Disability; Elderly; Epidemiology; Metabolic syndrome
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