title: Early detection of C-reactive protein and von Willebrand factor levels in Malaysian patients with acute coronary syndrome.
abstract: BACKGROUND
  Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD).
  
  
  METHODS
  The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated. Nine patients with stable coronary artery disease without previous history of ACS were enrolled as controls.
  
  
  RESULTS
  Serum and peripheral blood mRNA levels of CRP and vWF were significantly higher in ACS compared to control groups (P < 0.05).
  
  
  CONCLUSIONS
  Elevated levels of these markers in ACS may reflect an acute phase response due to endothelial dysfunction. Both CRP and vWF may add to the list of useful markers for early detection of ACS in hospitals of developing countries.
authors.affiliation: Clinical Research Centre, Sarawak General Hospital, Malaysia ; Faculty of Resource Science and Technology, University Malaysia Sarawak, Kota Samarahan, Malaysia.
authors.forename: Wen Ni
authors.initials: WN
authors.lastname: Tiong
authors.forename: Edmund Ui Hang
authors.initials: EU
authors.lastname: Sim
authors.forename: Alan Yean Yip
authors.initials: AY
authors.lastname: Fong
authors.forename: Tiong Kiam
authors.initials: TK
authors.lastname: Ong
keywords: Acute coronary syndrome; C-reactive protein; von Willebrand factor
references.citation: J Am Coll Cardiol. 2002 Feb 20;39(4):632-7
references.pmid: 11849862
references.citation: Am Heart J. 2000 Aug;140(2):324-8
references.pmid: 10925350
references.citation: Circulation. 2000 Jul 4;102(1):42-7
references.pmid: 10880413
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
references.pmid: 10807742
references.citation: Arch Intern Med. 2005 Jan 24;165(2):221-6
references.pmid: 15668370
references.citation: Clin Sci (Lond). 2000 May;98(5):531-5
references.pmid: 10781383
references.citation: N Engl J Med. 1992 Jan 23;326(4):242-50
references.pmid: 1727977
references.citation: J Thromb Haemost. 2005 Apr;3(4):662-4
references.pmid: 15842351
references.citation: Ann Acad Med Singap. 1997 May;26(3):285-9
references.pmid: 9285018
references.citation: Circulation. 2002 Apr 30;105(17):2019-23
references.pmid: 11980679
references.citation: Isr Med Assoc J. 2009 Oct;11(10):602-5
references.pmid: 20077946
references.citation: BMJ. 1993 Aug 14;307(6901):409-13
references.pmid: 8267742
references.citation: Acta Biochim Biophys Sin (Shanghai). 2008 May;40(5):426-36
references.pmid: 18465028
references.citation: N Engl J Med. 1997 Apr 3;336(14):973-9
references.pmid: 9077376
references.citation: Chest. 2004 Nov;126(5):1417-22
references.pmid: 15539707
references.citation: J Nucl Med. 2007 Nov;48(11):1800-15
references.pmid: 17942804
references.citation: Eur Heart J. 2004 Jul;25(14):1187-96
references.pmid: 15246636
references.citation: Cardiovasc Res. 1997 May;34(2):255-65
references.pmid: 9205537
references.citation: Circulation. 1994 Feb;89(2):872-81
references.pmid: 8313577
references.citation: Circulation. 2000 Oct 31;102(18):2165-8
references.pmid: 11056086