title: DNA analysis based on toehold-mediated strand displacement on graphene oxide.
abstract: Fluorescent dye-labeled probe DNA was immobilized on fluorescence-quenching graphene oxide (GO) through a capture DNA. When targets were added, the probes were released from the GO through toehold-mediated strand exchange. Higher emission recovery and more signal contrast were achieved relative to conventional methods that are based on direct adsorption of probes.
authors.affiliation: Department of Applied Chemistry and Biochemistry, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan. ykita@kumamoto-u.ac.jp toshi@chem.kumamoto-u.ac.jp.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyahata
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Akika
authors.initials: A
authors.lastname: Futamura
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsuura
authors.forename: Kazuto
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Michio
authors.initials: M
authors.lastname: Koinuma
authors.forename: Yasumichi
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ihara
mesh_terms: D001483:Base Sequence; D055592:Biophysical Phenomena; D015374:Biosensing Techniques; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D061925:Immobilized Nucleic Acids / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D061925:Immobilized Nucleic Acids; D006108:Graphite; D004247:DNA