title: Stem cell therapy for knee ligament, articular cartilage and meniscal injuries.
abstract: Knee injuries involving ligament, articular cartilage and meniscus are common. The capacity for regeneration and repair of these tissues is limited due to their poor vascularity. Autologous or allogeneic stem cell transplantation has the potential to stimulate healing of these tissues. A number of preclinical studies of stem cell therapy for repair of these injuries have produced promising results. Further clinical trials are needed to test the efficacy of this technique. This paper reviews the development strategies, advances and clinical applications of stem cell therapies that are applicable to knee ligament, articular cartilage and meniscal injuries.
authors.affiliation: University College London, Institute of Orthopaedic and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, United Kingdom. mukai.cg@mac.com.
authors.forename: Edward
authors.initials: E
authors.lastname: Ong
authors.forename: Mukai
authors.initials: M
authors.lastname: Chimutengwende-Gordon
authors.forename: Wasim
authors.initials: W
authors.lastname: Khan
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000628:therapy*; D008022:Ligaments / Q000293:injuries / Q000601:surgery*; D008592:Menisci, Tibial / Q000601:surgery*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D000070600:Tibial Meniscus Injuries; D014945:Wound Healing