title: Peptide-catalyzed diastereo- and enantioselective cyclopropanation of aromatic α,β-unsaturated aldehydes.
abstract: Highly diastereo- and enantioselective cyclopropanation of aromatic α,β-unsaturated aldehydes was achieved using a resin-supported peptide catalyst under aqueous conditions. In the peptide sequence, the residue possessing an oxygen atom with the appropriate length of the side chain was essential for attaining good diastereoselectivity.
authors.affiliation: Institute of Industrial Science, University of Tokyo , 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Akagawa
authors.forename: Shota
authors.initials: S
authors.lastname: Takigawa
authors.forename: Iman Sho
authors.initials: IS
authors.lastname: Nagamine
authors.forename: Ryota
authors.initials: R
authors.lastname: Umezawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D010455:Peptides / Q000737:chemistry*; D011407:Propane / Q000031:analogs & derivatives / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D010455:Peptides; D011407:Propane