title: Wernicke's encephalopathy that developed during the introduction period of peritoneal dialysis.
abstract: A 43-year-old man was admitted with end-stage renal disease caused by IgA nephropathy, and was treated with maintenance peritoneal dialysis. The patient developed general fatigue and appetite loss, and his symptoms were gradually aggravated by depression. After approximately 2 months on dialysis, the patient presented with altered consciousness and ophthalmoplegia. Wernicke's encephalopathy was diagnosed based on the presence of classic symptoms and the findings on magnetic resonance imaging. Thiamine replacement therapy was immediately initiated. The patient recovered from most of his neurological symptoms; however, the sequela of Korsakoff syndrome remained. A marginal thiamine deficiency in combination with predisposing factors must be considered when treating dialysis patients.
authors.affiliation: Division of Nephrology and Rheumatology, Faculty of Medicine, Fukuoka University, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Kenji
authors.initials: K
authors.lastname: Ito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Aki
authors.initials: A
authors.lastname: Shirakawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Abe
authors.forename: Satoru
authors.initials: S
authors.lastname: Ogahara
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Sasatomi
authors.forename: Tomoe
authors.initials: T
authors.lastname: Yasunaga
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ifuku
authors.forename: Jun
authors.initials: J
authors.lastname: Tsugawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
mesh_terms: D000328:Adult; D006801:Humans; D020915:Korsakoff Syndrome / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D013831:Thiamine / Q000097:blood / Q000627:therapeutic use; D013997:Time Factors; D014899:Wernicke Encephalopathy / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D013831:Thiamine