title: Why proteasome inhibitors cannot ERADicate multiple myeloma.
abstract: Proteasome inhibitors are key parts of our armamentarium against multiple myeloma, but the disease can become resistant through poorly defined mechanisms. In this issue of Cancer Cell, Leung-Hagesteijn and colleagues describe XBP1s(-) subpopulations of tumor cells that are resistant to bortezomib and may account for therapeutic failures in the clinic.
authors.affiliation: Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: rorlowsk@mdanderson.org.
authors.forename: Robert Z
authors.initials: RZ
authors.lastname: Orlowski
mesh_terms: D004268:DNA-Binding Proteins / Q000172:deficiency*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics*; D061988:Proteasome Inhibitors / Q000627:therapeutic use*; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000172:deficiency*; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D061988:Proteasome Inhibitors; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human
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