title: Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review.
abstract: Inflammatory myofibroblastic tumors (IMTs) are categorized as intermediate biologic neoplasms, whereas IMTs with genetic features of ran-binding protein 2 (RANBP2) and anaplastic lymphoma kinase (ALK) rearrangement (IMT-RAs) are possibly related to a more aggressive clinical course. However, fewer than 10 cases of IMT-RA have been reported to date. Herein, we present 2 new cases of IMT-RA in which both tumors recurred quickly after primary surgery; one patient died 3 months later from the disease, and the other patient has been living with the disease for 12 months. IMT-RAs are characterized by noncohesive epithelioid and rounded tumoral cell morphology, commonly derived from pelvic and peritoneal cavities, and frequently show larger tumor sizes. The relation between the clinicopathologic features and poor prognosis of IMT-RA is discussed.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3314123381007714.
authors.affiliation: Department of Pathology, the Second Shenzhen People's Hospital, Sungang West Road, Shenzhen 518035, China. hongguansz@sina.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Yin
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Hong
authors.initials: H
authors.lastname: Guan
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Huang
authors.forename: John K C
authors.initials: JK
authors.lastname: Chan
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D048430:Cell Shape; D017809:Fatal Outcome; D005260:Female; D050939:Gene Fusion; D015321:Gene Rearrangement; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007249:Inflammation / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D007414:Intestinal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics*; D009364:Neoplasm Recurrence, Local; D009379:Neoplasms, Muscle Tissue / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D028861:Nuclear Pore Complex Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D010641:Phenotype; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult
chemical_list: C529682:ALK-RANBP2 fusion protein, human; D014408:Biomarkers, Tumor; D018832:Molecular Chaperones; D028861:Nuclear Pore Complex Proteins; D015514:Oncogene Proteins, Fusion; C094493:ran-binding protein 2; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
references.citation: Mod Pathol. 2002 Sep;15(9):931-8
references.pmid: 12218210
references.citation: Am J Pathol. 2001 Aug;159(2):411-5
references.pmid: 11485898
references.citation: Mod Pathol. 2001 Jun;14(6):569-76
references.pmid: 11406658
references.citation: Genes Chromosomes Cancer. 2003 May;37(1):98-105
references.pmid: 12661011
references.citation: Am J Surg Pathol. 2007 Apr;31(4):509-20
references.pmid: 17414097
references.citation: Cancer Genet Cytogenet. 2007 Jul 15;176(2):107-14
references.pmid: 17656252
references.citation: Nature. 1995 Jul 13;376(6536):184-8
references.pmid: 7603572
references.citation: Am J Surg Pathol. 2012 Jan;36(1):154-60
references.pmid: 22082606
references.citation: Am J Surg Pathol. 2011 Jan;35(1):135-44
references.pmid: 21164297
references.citation: Cancer Res. 2010 Dec 15;70(24):10038-43
references.pmid: 21030459
references.citation: J Clin Pathol. 2008 Apr;61(4):428-37
references.pmid: 17938159
references.citation: Hum Pathol. 2008 Dec;39(12):1854-8
references.pmid: 18701132
references.citation: Cancer. 1990 Sep 15;66(6):1253-65
references.pmid: 2119249
references.citation: Acta Chir Belg. 2003 Feb;103(1):105-7
references.pmid: 12658888
references.citation: N Engl J Med. 2010 Oct 28;363(18):1727-33
references.pmid: 20979472
references.citation: Leukemia. 2010 Jun;24(6):1197-200
references.pmid: 20428197
references.citation: Am J Surg Pathol. 2001 Nov;25(11):1364-71
references.pmid: 11684952
references.citation: Gen Thorac Cardiovasc Surg. 2014 Mar;62(3):191-4
references.pmid: 23345154
references.citation: Diagn Pathol. 2013 Jun 06;8:90
references.pmid: 23742153
references.citation: Diagn Pathol. 2007 Jun 18;2:19
references.pmid: 17577399
references.citation: Clin Cancer Res. 2011 May 15;17(10):3341-8
references.pmid: 21430068
references.citation: Am J Surg Pathol. 2004 Dec;28(12):1652-4
references.pmid: 15577687