title: The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility.
abstract: BACKGROUND
  Previous studies have investigated the association between single nucleotide polymorphisms (SNPs) located in microRNAs (miRNAs) and breast cancer susceptibility; however, because of their limited statistical power, many discrepancies are revealed in these studies. The meta-analysis presented here aimed to identify and characterize the roles of miRNA SNPs in breast cancer risk, and evaluate the associations of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 with breast cancer susceptibility, respectively.
  
  
  RESULTS
  The PubMed and Embases databases were searched updated to 31(st) December, 2012. The complete data of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 from case-control studies for breast cancer were analyzed by odds ratios (ORs) with 95% confidence intervals (CIs) to reveal the associations of SNPs in miRNAs with breast cancer susceptibility. Totally, six studies for rs2910164 in miR-146a, involving 4225 cases and 4469 controls; eight studies for rs11614913 in miR-196a, involving 4110 cases and 5100 controls; and three studies of rs3746444 in miR-499, involving 2588 cases and 3260 controls, were investigated in the meta-analysis. The rs11614913 (TT+CT) genotype of miR-196a2 was revealed to be associated with a decreased breast cancer susceptibility compared with the CC genotypes (OR = 0.906, 95% CI: 0.825-0.995, P = 0.039); however, no significant associations were observed between rs2910164 in miR-146a (or rs3746444 in miR-499) and breast cancer susceptibility.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer.
authors.affiliation: Department of Epidemiology, Binzhou Medical University, YanTai, ShanDong, P.R. China ; Department of Epidemiology, School of Public Health, Shandong University, JiNan, ShanDong, P.R. China.
authors.forename: Ping-Yu
authors.initials: PY
authors.lastname: Wang
authors.forename: Zong-Hua
authors.initials: ZH
authors.lastname: Gao
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Li
authors.forename: Bao-Fa
authors.initials: BF
authors.lastname: Jiang
authors.forename: Shu-Yang
authors.initials: SY
authors.lastname: Xie
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C542542:MIRN146 microRNA, human; C542543:MIRN196 microRNA, human; C548683:MIRN499 microRNA, human; D035683:MicroRNAs
references.citation: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13653-8
references.pmid: 21810988
references.citation: Curr Opin Genet Dev. 2006 Apr;16(2):203-8
references.pmid: 16503132
references.citation: Gac Sanit. 2009 Mar-Apr;23(2):158
references.pmid: 19249134
references.citation: Pathology. 2010 Dec;42(7):669-73
references.pmid: 21080878
references.citation: Nat Genet. 2007 May;39(5):673-7
references.pmid: 17401365
references.citation: Clin Chem Lab Med. 2011 Sep 09;49(12):2073-80
references.pmid: 21902575
references.citation: Eur J Cancer Care (Engl). 2012 Mar;21(2):274-80
references.pmid: 22074121
references.citation: Cancer Genomics Proteomics. 2012 May-Jun;9(3):115-8
references.pmid: 22593246
references.citation: Mol Biol Rep. 2013 Apr;40(4):3181-6
references.pmid: 23266669
references.citation: PLoS One. 2007 Sep 05;2(9):e841
references.pmid: 17786212
references.citation: Nat Rev Cancer. 2010 Jun;10(6):389-402
references.pmid: 20495573
references.citation: Cell. 2005 Jan 14;120(1):21-4
references.pmid: 15652478
references.citation: Mutagenesis. 2012 Nov;27(6):779-88
references.pmid: 22952151
references.citation: Gene. 2011 Oct 15;486(1-2):104-9
references.pmid: 21807077
references.citation: PLoS One. 2012;7(2):e30049
references.pmid: 22363415
references.citation: Carcinogenesis. 2008 Oct;29(10):1963-6
references.pmid: 18660546
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: Mol Biol Rep. 2012 Apr;39(4):4571-9
references.pmid: 21947843
references.citation: Proc Natl Acad Sci U S A. 2008 May 20;105(20):7269-74
references.pmid: 18474871
references.citation: Mol Biol Rep. 2012 Dec;39(12):10433-8
references.pmid: 23053947
references.citation: BMC Med Genet. 2012 Dec 10;13:119
references.pmid: 23228090
references.citation: Nat Rev Cancer. 2006 Apr;6(4):259-69
references.pmid: 16557279
references.citation: RNA. 2005 Dec;11(12):1753-61
references.pmid: 16314451
references.citation: Cancer Prev Res (Phila). 2008 Nov;1(6):460-9
references.pmid: 19138993
references.citation: Carcinogenesis. 2010 Oct;31(10):1805-12
references.pmid: 20732906
references.citation: Biostatistics. 2001 Dec;2(4):463-71
references.pmid: 12933636
references.citation: PLoS One. 2011 Mar 31;6(3):e18108
references.pmid: 21483822
references.citation: Hum Mutat. 2009 Jan;30(1):79-84
references.pmid: 18634034
references.citation: N Engl J Med. 2005 Oct 27;353(17):1793-801
references.pmid: 16251535
references.citation: Carcinogenesis. 2010 Dec;31(12):2124-6
references.pmid: 20810544
references.citation: Hum Mutat. 2010 Jan;31(1):E1052-7
references.pmid: 19847796
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Science. 2005 Sep 2;309(5740):1519-24
references.pmid: 16141061
references.citation: Nat Biotechnol. 2008 Apr;26(4):462-9
references.pmid: 18362881
references.citation: Nature. 2005 Jun 9;435(7043):834-8
references.pmid: 15944708
references.citation: Twin Res Hum Genet. 2011 Oct;14(5):417-21
references.pmid: 21962133
references.citation: PLoS One. 2012;7(2):e31615
references.pmid: 22363684
references.citation: Cancer Res. 2009 Jul 15;69(14):5970-7
references.pmid: 19567675
references.citation: Exp Ther Med. 2012 Feb;3(2):324-330
references.pmid: 22969890
references.citation: Mol Carcinog. 2012 Oct;51 Suppl 1:E65-73
references.pmid: 22161766
references.citation: Mol Biol Rep. 2012 Jan;39(1):269-75
references.pmid: 21625865
references.citation: Hum Mutat. 2011 Sep;32(9):1004-7
references.pmid: 21591024
references.citation: Mol Biol Rep. 2012 Jun;39(6):7019-23
references.pmid: 22311030
references.citation: Cytokine. 2011 Dec;56(3):589-92
references.pmid: 21907588
references.citation: Clin Chem. 2009 Apr;55(4):623-31
references.pmid: 19246618
references.citation: Breast Cancer Res Treat. 2011 Jan;125(2):571-4
references.pmid: 20640596
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1502-5
references.pmid: 19164563
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120