title: Synthesis and characterization of antiseptic-based poly(anhydride-esters).
abstract: Poly(anhydride-esters) were prepared from catechol, fenticlor and hexachlorophene. The molecular weights (Mw) of the polymers were typically > 10,000 Da with glass transition temperatures (Tg) ranging from 23 to 84 °C. The thermal characteristics of the polymers paralleled the melting temperatures of the chemically incorporated antiseptic molecules. Thein vitrorelease of the chemically incorporated antiseptic molecules were monitored over a 12 week period. For comparison, thein vitrorelease of physically admixed antiseptic molecules were also observed. After 12 weeks, the polymers were not completely degraded with drug release ranging from less than 1 to 55 %. Sessile-drop contact angles indicated that the polymers were relatively hydrophobic, contributing to the slow polymer degradation rates.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854-8087.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Schmeltzer
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
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