title: Magnesium metal--a potential biomaterial with antibone cancer properties.
abstract: Reactive oxygen plays an important role in the pathogenesis of many serious illnesses, including bony cancer. Recently, it has been suggested that hydrogen (H2), a selective antioxidant, can effectively scavenge free radicals. Biomedical magnesium (Mg) used for bone defect repair in the surgery of bony cancer could release H2 because of the degradation, so Mg might have the potential to prevent bony cancer from metastasis and recurrence. In this study, alkali-heat treatment method was employed to modify the surface structure of Mg metal, so as to control the degradation of Mg metal and the H2 releasing rate. Then the released H2 was introduced to the Fenton Reaction system to detect its effect on scavenging free radicals. The modified Mg metal was employed as the substrate for bone cancer cell culture to study the effect of the H2 releasing on scavenging free radicals in the cells. It is found that the H2 released from the Mg degradation could scavenge free radicals both in the Fenton Reaction system and bone cancer cells. The effect on the scavenging free radical is proportional to the rate of H2 releasing. It suggested that Mg might be a potential material with anti-bone cancer properties. It is hopeful to both repair the bone defect and prevent bony cancer from metastasis and recurrence for the bony cancer patients by biomedical Mg metal.
authors.affiliation: Engineering Research Center in Biomaterials, Sichuan University, Chengdu, 610064, China; National Engineering Research Center for Biomaterials, Chengdu, 610064, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Nan
authors.forename: Chen
authors.initials: C
authors.lastname: Yangmei
authors.forename: Yang
authors.initials: Y
authors.lastname: Bangcheng
mesh_terms: D000468:Alkalies / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000494:pharmacology / Q000627:therapeutic use*; D001826:Body Fluids / Q000737:chemistry; D001859:Bone Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D006859:Hydrogen; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D008274:Magnesium / Q000494:pharmacology / Q000627:therapeutic use*; D014961:X-Ray Diffraction
chemical_list: D000468:Alkalies; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D006859:Hydrogen; D006861:Hydrogen Peroxide; D007501:Iron; D008274:Magnesium
keywords: H2 releasing; anti-bone cancer; biodegradation; free radicals scavenging; magnesium metal