title: The -159C/T polymorphism in the CD14 gene and tuberculosis risk: a meta-analysis.
abstract: BACKGROUND
  The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to tuberculosis, but the results were inconclusive. The present meta-analysis aimed to perform a comprehensive assessment of the literature on the possible association between the -159C/T polymorphism and tuberculosis risk.
  
  
  METHODS
  We searched in Pubmed and Embase for studies evaluating the association between the -159C/T gene polymorphism and tuberculosis risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software.
  
  
  RESULTS
  A total of seven case-control studies involving 3253 subjects (1,574 tuberculosis cases and 1,679 controls) were included. Combined analysis revealed an obvious association between this polymorphism and tuberculosis risk (odds ratio=1.66 and 95% confidence interval: 1.23-2.25, P<0.05 for TT vs. TC+ CC). Sub-group analysis by ethnicity suggested that the risk of tuberculosis associated with the -159C/T polymorphism was significantly elevated among Asians (odds ratio=1.87 and 95% confidence interval: 1.58-2.21, P<0.05 for TT vs. TC+ CC).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the -159C/T polymorphism in the CD14 gene contributes to tuberculosis susceptibility. To further investigate gene-gene and gene-environment interactions between this polymorphism and tuberculosis risk, more studies are needed.
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Shujin
authors.initials: S
authors.lastname: Guo
authors.forename: Liuqun
authors.initials: L
authors.lastname: Jia
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wen
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: D018950:Lipopolysaccharide Receptors
keywords: CD14; Meta-analysis.; Polymorphism; Tuberculosis
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