title: Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells.
abstract: A 405 nm light-activatable terthiophene-based tetrazole was designed that reacts with a fumarate dipolarophile with the second-order rate constant k2 exceeding 10(3) M(-1) s(-1). The utility of this laser-activatable tetrazole in imaging microtubules in a spatiotemporally controlled manner in live cells was demonstrated.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, NY 14260, USA. qinglin@buffalo.edu.
authors.forename: Peng
authors.initials: P
authors.lastname: An
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Yu
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D057930:Click Chemistry; D018360:Crystallography, X-Ray; D005650:Fumarates / Q000737:chemistry*; D006801:Humans; D007834:Lasers; D008870:Microtubules / Q000737:chemistry; D015394:Molecular Structure; D010777:Photochemistry; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000475:Alkenes; D005650:Fumarates; D013777:Tetrazoles; D013876:Thiophenes; C045574:1H-tetrazole
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