title: Linking neural activity to complex decisions.
abstract: In the 1990s, seminal work from Newsome and colleagues made it possible to study the neuronal mechanisms of simple perceptual decisions. The key strength of this work was the clear and direct link between neuronal activity and choice processes. Since then, a great deal of research has extended these initial discoveries to more complex forms of decision making, with the goal of bringing the same strength of linkage between neural and psychological processes. Here, we discuss the progress of two such research programs, namely our own, that are aimed at understanding memory-guided decisions and reward-guided decisions. These problems differ in the relevant brain areas, in the progress that has been achieved, and in the extent of broader understanding achieved so far. However, they are unified by the use of theoretical insights about how to link neuronal activity to decisions.
authors.affiliation: Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, Rochester, New York.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Hayden
authors.affiliation: Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, Rochester, New York.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Pasternak
mesh_terms: D000818:Animals; D002755:Choice Behavior / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology; D000882:Haplorhini; D009039:Motion Perception / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology*; D011897:Random Allocation; D012201:Reward; D014793:Visual Cortex / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*
references.citation: Trends Cogn Sci. 2004 Jun;8(6):261-5
references.pmid: 15165551
references.citation: J Neurophysiol. 2011 Sep;106(3):1260-73
references.pmid: 21676932
references.citation: Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1053-62
references.pmid: 12217173
references.citation: J Comp Neurol. 2006 Sep 10;498(2):227-51
references.pmid: 16856142
references.citation: J Neurosci. 2012 May 16;32(20):6851-8
references.pmid: 22593054
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21842-7
references.pmid: 21098286
references.citation: J Neurosci. 2012 Mar 14;32(11):3791-808
references.pmid: 22423100
references.citation: Science. 2003 Aug 22;301(5636):1104-7
references.pmid: 12934011
references.citation: J Neurosci. 2001 Jul 1;21(13):4809-21
references.pmid: 11425908
references.citation: J Cogn Neurosci. 2011 Nov;23(11):3355-65
references.pmid: 21452948
references.citation: J Neurosci. 2012 Feb 22;32(8):2747-61
references.pmid: 22357858
references.citation: Neuron. 2011 Jan 13;69(1):170-82
references.pmid: 21220107
references.citation: Science. 2012 Oct 5;338(6103):132-5
references.pmid: 23042897
references.citation: J Neurosci. 2003 Jun 15;23(12):5235-46
references.pmid: 12832548
references.citation: Science. 2004 Apr 9;304(5668):307-10
references.pmid: 15073380
references.citation: Nat Rev Neurosci. 2005 Feb;6(2):97-107
references.pmid: 15654324
references.citation: Neuropsychologia. 2006;44(12):2411-20
references.pmid: 16757005
references.citation: Annu Rev Neurosci. 2007;30:31-56
references.pmid: 17417936
references.citation: Front Neurosci. 2010 Sep 17;4:
references.pmid: 20922060
references.citation: Nat Neurosci. 2011 Mar;14(3):366-72
references.pmid: 21317906
references.citation: Nat Neurosci. 2002 Oct;5(10):985-94
references.pmid: 12244324
references.citation: Nature. 1989 Sep 7;341(6237):52-4
references.pmid: 2770878
references.citation: Nat Neurosci. 2012 Jun 17;15(7):960-1
references.pmid: 22706268
references.citation: J Neurosci. 1996 Aug 15;16(16):5154-67
references.pmid: 8756444
references.citation: J Neurosci. 2007 Jul 25;27(30):8122-37
references.pmid: 17652603
references.citation: J Neurosci. 2003 Jul 23;23(16):6475-9
references.pmid: 12878688
references.citation: Nat Neurosci. 2009 Dec;12(12):1594-600
references.pmid: 19915566
references.citation: Neuron. 2009 Dec 10;64(5):730-43
references.pmid: 20005828
references.citation: Nature. 2006 Aug 10;442(7103):692-5
references.pmid: 16878143
references.citation: Science. 2009 May 15;324(5929):948-50
references.pmid: 19443783
references.citation: Nat Neurosci. 2010 Oct;13(10):1292-8
references.pmid: 20835253
references.citation: Nat Neurosci. 2004 Apr;7(4):404-10
references.pmid: 15004564
references.citation: Nat Neurosci. 2006 Feb;9(2):276-82
references.pmid: 16429134
references.citation: J Neurosci. 2011 Mar 16;31(11):4178-87
references.pmid: 21411658
references.citation: Nat Rev Neurosci. 2003 Mar;4(3):203-18
references.pmid: 12612633
references.citation: Neuron. 2010 Apr 29;66(2):300-14
references.pmid: 20435005
references.citation: Curr Opin Neurobiol. 2012 Dec;22(6):1039-46
references.pmid: 23026743
references.citation: Nat Rev Neurosci. 2006 Jun;7(6):485-91
references.pmid: 16715056
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5948-53
references.pmid: 19293382
references.citation: Neuron. 2002 Oct 10;36(2):265-84
references.pmid: 12383781
references.citation: Nature. 2006 Feb 16;439(7078):865-70
references.pmid: 16482160
references.citation: J Neurosci. 2007 Aug 1;27(31):8366-77
references.pmid: 17670983
references.citation: J Neurosci. 2002 Nov 1;22(21):9530-40
references.pmid: 12417677
references.citation: J Neurosci. 2012 Mar 14;32(11):3830-41
references.pmid: 22423103
references.citation: Front Neurosci. 2013 Feb 26;7:18
references.pmid: 23550043
references.citation: Nat Neurosci. 2011 Jun 05;14(7):933-9
references.pmid: 21642973
references.citation: Brain Res. 1979 Aug 3;171(2):213-24
references.pmid: 111772
references.citation: Nat Neurosci. 2004 Dec;7(12):1370-5
references.pmid: 15558064
references.citation: J Neurosci. 2006 Jul 26;26(30):7779-90
references.pmid: 16870724
references.citation: Nat Rev Neurosci. 2008 Jul;9(7):545-56
references.pmid: 18545266
references.citation: Annu Rev Psychol. 2006;57:87-115
references.pmid: 16318590
references.citation: J Neurophysiol. 2001 Jan;85(1):187-96
references.pmid: 11152719
references.citation: Neuron. 2008 Oct 9;60(1):19-25
references.pmid: 18940585
references.citation: J Cogn Neurosci. 2009 Jun;21(6):1162-78
references.pmid: 18752411
references.citation: Eur J Neurosci. 2009 May;29(10):2061-73
references.pmid: 19453638
references.citation: Science. 2003 Oct 3;302(5642):120-2
references.pmid: 14526085
references.citation: Neuron. 2002 Oct 10;36(2):323-32
references.pmid: 12383785
references.citation: Cogn Affect Behav Neurosci. 2007 Dec;7(4):327-36
references.pmid: 18189006
references.citation: Cereb Cortex. 2006 Jul;16(7):1040-55
references.pmid: 16207931
references.citation: J Neurosci. 2009 May 20;29(20):6635-48
references.pmid: 19458234
references.citation: Judgm Decis Mak. 2008 Jun 1;3(5):389-395
references.pmid: 19844596
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Cereb Cortex. 2000 Nov;10(11):1053-65
references.pmid: 11053227
references.citation: J Neurosci. 2006 Nov 8;26(45):11726-42
references.pmid: 17093094
references.citation: Neuron. 2011 Jun 23;70(6):1054-69
references.pmid: 21689594
references.citation: Nat Neurosci. 2007 May;10(5):647-56
references.pmid: 17450137
references.citation: Vis Neurosci. 1996 Jan-Feb;13(1):87-100
references.pmid: 8730992
references.citation: Science. 2002 May 31;296(5573):1709-11
references.pmid: 12040201
references.citation: Nature. 2006 May 11;441(7090):223-6
references.pmid: 16633341
references.citation: Neuron. 2004 Apr 22;42(2):297-310
references.pmid: 15091344
references.citation: PLoS Biol. 2004 Mar;2(3):E77
references.pmid: 15024425
references.citation: J Neurosci. 2009 Jan 21;29(3):765-74
references.pmid: 19158302
references.citation: Psychol Rev. 2001 Jul;108(3):624-52
references.pmid: 11488380
references.citation: J Neurosci. 2013 Jan 16;33(3):972-86
references.pmid: 23325236
references.citation: J Neurosci. 1993 Apr;13(4):1460-78
references.pmid: 8463829
references.citation: Annu Rev Neurosci. 2011;34:333-59
references.pmid: 21456961
references.citation: Science. 2004 Feb 13;303(5660):1023-6
references.pmid: 14963333
references.citation: J Comp Neurol. 1988 Oct 15;276(3):313-42
references.pmid: 3192766
references.citation: Nature. 1999 Jul 15;400(6741):233-8
references.pmid: 10421364
references.citation: Nat Neurosci. 2011 Oct 30;14(12):1581-9
references.pmid: 22037498
references.citation: Curr Opin Neurobiol. 2004 Apr;14(2):169-77
references.pmid: 15082321
references.citation: Nat Neurosci. 2012 Jan 08;15(3):470-6, S1-3
references.pmid: 22231429
references.citation: J Neurosci. 2007 Aug 1;27(31):8161-5
references.pmid: 17670959
references.citation: Nature. 1990 Jul 12;346(6280):174-7
references.pmid: 2366872