title: Pulmonary hypertension complicating interstitial lung disease and COPD.
abstract: Pulmonary hypertension (PH) may complicate parenchymal lung disease, specifically interstitial lung diseases and chronic obstructive pulmonary disease, and uniformly increases the mortality risk. The epidemiology and degree of PH is variable and unique to the underlying lung disease. The clinician should exercise a high index of suspicion for PH complicating parenchymal lung disease especially given the nonspecific symptomatology and the limitations of echocardiography in this patient population. In general, PH-specific therapies in this setting have been poorly studied, with concern for increased shunting and/or ventilation/perfusion (V/Q) mismatch and resultant hypoxemia. A better understanding of the mechanisms underlying PH related to parenchymal lung disease may lead to novel pharmacological targets to prevent or treat this serious complication.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Shino
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Lynch
authors.forename: Rajeev
authors.initials: R
authors.lastname: Saggar
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Abtin
authors.forename: John A
authors.initials: JA
authors.lastname: Belperio
authors.forename: Rajan
authors.initials: R
authors.lastname: Saggar
mesh_terms: D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000628:therapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000628:therapy; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications / Q000628:therapy; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000628:therapy; D008175:Lung Neoplasms / Q000150:complications / Q000628:therapy; D018192:Lymphangioleiomyomatosis / Q000150:complications / Q000628:therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000628:therapy; D012507:Sarcoidosis / Q000150:complications / Q000628:therapy; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000628:therapy