title: Relationships between serum omentin-1 concentration and bone mineral density, and bone biochemical markers in Chinese women.
abstract: BACKGROUND
  Omentin-1, as a newly discovered adipocytokine, plays an important role in bone metabolism. However, the association between circulating omentin-1 level and bone mineral density (BMD) in Chinese women has never been investigated.
  
  
  METHODS
  Serum omentin-1, adiponectin, leptin, bone turnover biochemical markers, BMD were determined in 225 premenopausal women and 285 postmenopausal women.
  
  
  RESULTS
  In premenopausal Chinese women, omentin-1 level was significantly higher compared to postmenopausal women. The multiple linear stepwise regression analysis showed that lean mass, omentin-1 and weight were independent predictors of BMD in premenopausal women. Omentin-1 was negatively correlated with bone-specific alkaline phosphatase (BAP) and bone cross-linked N-terminal telopeptides of type I collagen (NTX) in premenopausal women. However the omentin-1 was not the predictor of BMD in postmenopausal women.
  
  
  CONCLUSIONS
  Omentin-1 is an independent predictor of BMD in premenopausal Chinese women, and shows a negative correlation with bone turnover biochemical markers. Our results suggest that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in premenopausal women.
authors.affiliation: Department of Endocrinology, First affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Tie-Jian
authors.initials: TJ
authors.lastname: Jiang
authors.forename: Lan
authors.initials: L
authors.lastname: Liao
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D002681:China; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: BAP; BMD; BMI; Bone mineral density; Chinese women; N-telopeptides of typeIcollagen; NTX; OPG; Omentin-1; PTH; RANKL; body mass index., dual energy X-ray absorptiometry; bone alkaline phosphatase; bone mineral density; osteoprotegerin; parathyroid hormone; receptor activator of the NF-kB ligand