title: A randomised comparison of lidocaine 2% gel and proparacaine 0.5% eye drops in paediatric squint surgery.
abstract: We conducted a randomised trial comparing lidocaine 2% gel with proparacaine 0.5% eye drops in children having elective squint surgery. One hundred and forty children aged between 3 and 14 years were recruited. The requirement for intra-operative fentanyl and postoperative ibuprofen was significantly less in the lidocaine group compared with the proparacaine group (1 (1.7%) vs 12 (18.5%), p=0.002 and 16 (27.6%) 38 (58.5%), p=0.001, respectively). The incidence of postoperative nausea and vomiting was significantly less in the lidocaine group compared with the proparacaine group (6 (10.3%) vs 16 (24.6%), p=0.04). There were no differences between the groups in terms of incidence and severity of the oculocardiac reflex. We conclude that, compared with proparacaine 0.5% eye drops, a single application of lidocaine 2% gel improves peri-operative analgesia and reduces the incidence of postoperative nausea and vomiting in elective paediatric squint surgery.
authors.affiliation: Department of Anaesthesiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Sinha
authors.lastname: Chandralekha
authors.forename: M
authors.initials: M
authors.lastname: Batra
authors.forename: B R
authors.initials: BR
authors.lastname: Ray
authors.forename: V K
authors.initials: VK
authors.lastname: Mohan
authors.forename: R
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005782:Gels; D006801:Humans; D015994:Incidence; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D016343:Monitoring, Intraoperative; D009883:Ophthalmic Solutions; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000453:epidemiology / Q000517:prevention & control; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology; D011430:Propoxycaine / Q000008:administration & dosage*; D011446:Prospective Studies; D012024:Reflex, Oculocardiac / Q000187:drug effects; D013285:Strabismus / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D005782:Gels; D009883:Ophthalmic Solutions; D008012:Lidocaine; C005717:proxymetacaine; D011430:Propoxycaine