title: Urinary bladder matrix for the treatment of recalcitrant nonhealing radiation wounds.
abstract: Chronic wounds in previously radiated tissue are challenging to treat. In this article, the authors describe 3 such wounds that failed to heal despite multiple treatments with traditional wound healing methods. Treatment with porcine urinary bladder matrix, an extracellular matrix material, was initiated to facilitate epithelialization and promote wound healing. MatriStem powder (ACell, Inc, Columbia, Maryland), MatriStem (ACell, Inc) sheet, and DuoDerm (ConvaTec, Skillman, New Jersey) were applied biweekly and resulted in complete wound closure within 3 weeks of initial application for all 3 cases. All wounds remained closed 9 months following treatment, suggesting a role for urinary bladder matrix in the management of chronic wounds in the setting of irradiated tissue.
authors.affiliation: Elizabeth A. Rommer, BS, is research coordinator; Mirna Peric, BA, is a research assistant; and Alex Wong, MD, FACS, is assistant professor of surgery, all in the Division of Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rommer
authors.forename: Mirna
authors.initials: M
authors.lastname: Peric
authors.forename: Alex
authors.initials: A
authors.lastname: Wong
mesh_terms: D000368:Aged; D000818:Animals; D047070:Bandages, Hydrocolloid; D002908:Chronic Disease; D005109:Extracellular Matrix / Q000637:transplantation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D013552:Swine; D001743:Urinary Bladder