title: Superficial necrolytic dermatitis in a dog with an insulin-producing pancreatic islet cell carcinoma.
abstract: A 10-year-old dog presented with convulsive crisis and symmetrical hyperkeratotic cutaneous lesions affecting the abdomen, inguinal area, eyelids, muzzles, both pinnae, and all the paw pads. Hypoglycemia and hyperinsulinemia were the main biochemical findings. A mass 2 cm in diameter was detected within the left pancreatic lobe by ultrasonography. It was surgically removed and histologically and immunohistochemically diagnosed as an insulin-producing pancreatic islet cell carcinoma. The animal was eventually euthanized due to lack of clinical improvement. At necropsy, metastatic nodules were observed in the pancreatic lymph nodes and liver. Histopathological findings of cutaneous lesions were highly suggestive of superficial necrolytic dermatitis and were interpreted as a paraneoplastic syndrome derived from the islet cell carcinoma. To the authors' knowledge, this is the first report of superficial necrolytic dermatitis associated with an insulin-producing pancreatic neuroendocrine carcinoma in dogs.
authors.affiliation: Servei de Diagnòstic de Patologia Veterinària, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain Departament de Sanitat i Anatomia Animals, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain marcosisidoro.ayza@e-campus.uab.cat.
authors.forename: M
authors.initials: M
authors.lastname: Isidoro-Ayza
authors.affiliation: Fundació Hospital Clínic Veterinari, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lloret
authors.affiliation: Fundació Hospital Clínic Veterinari, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain Departament de Medicina i Cirurgia Animals, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Bardagí
authors.affiliation: Fundació Hospital Clínic Veterinari, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain Departament de Medicina i Cirurgia Animals, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ferrer
authors.affiliation: Servei de Diagnòstic de Patologia Veterinària, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain Departament de Sanitat i Anatomia Animals, Veterinary School, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Martínez
mesh_terms: D007516:Adenoma, Islet Cell; D000818:Animals; D003872:Dermatitis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007003:Hypoglycemia / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D007328:Insulin / Q000378:metabolism*; D008207:Lymphatic Metastasis; D018358:Neuroendocrine Tumors / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D013030:Spain
chemical_list: D007328:Insulin
keywords: dog; endocrine; insulinoma; integument; metabolic; oncology; superficial necrolytic dermatitis