title: Three new phenanthrenes, a new stilbenoid isolated from the roots of Stemona tuberosa Lour. and their cytotoxicity.
abstract: Three new phenanthrenes, stemophenanthrenes A-C (1-3), along with one new stilbenoid, isopinosylvin A (4) and a known compound methyl ferulate (5), were isolated and identified from the roots of Stemona tuberosa Lour. plants, collected in Attapu province (Laos). Their structures were elucidated by spectroscopic analysis (FT-ICR-MS, IR, UV, 1D and 2D NMR). These compounds show moderate cytotoxic activity against four cancer cell lines, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).
authors.affiliation: a Faculty of Chemistry, Hanoi National University of Education , 136 Xuan Thuy Road, Cau Giay District, Hanoi City , Viet Nam.
authors.forename: Vong Anatha
authors.initials: VA
authors.lastname: Khamko
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
authors.forename: Pham Huu
authors.initials: PH
authors.lastname: Dien
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D041901:Stemonaceae / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010616:Phenanthrenes