title: Post renal transplant type 2 diabetes mellitus in a case of familial juvenile nephrophthisis.
abstract: Familial juvenile nephronophtisis, an autosomal recessive tubulointerstitial chronic nephritis, is characterized by progressive renal disease and end stage renal failure, which require kidney transplantation. Post-transplant diabetes mellitus (PTDM) incidence after kidney transplantation varies from 4-25%. Obesity, positive oral glucose tolerance test, metabolic syndromes, and post-transplantation multi-drug, high dose, long-term immunosuppressive therapy are the risk factors incriminated.We present the case of a 15-year-old overweight boy who was diagnosed with familial juvenile nephronophtisis five years before, afterwards progressive renal disease and end stage renal failure. This young patient developed PTDM three years after renal transplantation. His underweight brother, with the same medical history, did not develop PTDM.Transplantation was mandatory for a child with familial juvenile nephronophtisis.The case illustrates the risk factors for PTDM.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Department of Pediatrics, Bucharest, Romania ; "MS Curie" Emergency Children's Hospital, Bucharest, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Balgradean
authors.forename: Eliza
authors.initials: E
authors.lastname: Cinteza
authors.forename: Dumitru
authors.initials: D
authors.lastname: Ferechide
keywords: end stage renal failure; familial juvenile nephronophthisis; post–transplant diabetes mellitus
references.citation: Nephrol Dial Transplant. 1997 Mar;12(3):625-6
references.pmid: 9075164
references.citation: Am J Kidney Dis. 1996 Feb;27(2):216-9
references.pmid: 8659496
references.citation: Nephrol Dial Transplant. 2008 Jun;23(6):1816-8
references.pmid: 18326882
references.citation: Kidney Int. 1997 Jan;51(1):261-9
references.pmid: 8995741
references.citation: Am J Kidney Dis. 2000 Jan;35(1):44-51
references.pmid: 10620543
references.citation: Kidney Int Suppl. 1993 Oct;43:S104-9
references.pmid: 8246361
references.citation: Transplantation. 2007 Jul 15;84(1):50-5
references.pmid: 17627237
references.citation: Hum Mol Genet. 1996 Mar;5(3):367-71
references.pmid: 8852662
references.citation: Endocrinol Metab Clin North Am. 2007 Dec;36(4):873-90; vii
references.pmid: 17983926
references.citation: Pediatr Nephrol. 1996 Feb;10(1):22-4
references.pmid: 8611349
references.citation: Pediatr Nephrol. 2009 Dec;24(12):2333-44
references.pmid: 18607645
references.citation: Diabetol Metab Syndr. 2009 Oct 05;1(1):14
references.pmid: 19825150
references.citation: Diabetes Care. 2004 May;27(5):1047-53
references.pmid: 15111519
references.citation: Nephrol Dial Transplant. 2003 Jan;18(1):164-71
references.pmid: 12480976
references.citation: Minerva Urol Nefrol. 2003 Mar;55(1):33-42
references.pmid: 12773965
references.citation: Nephrol Dial Transplant. 2006 Sep;21(9):2660-3
references.pmid: 16782989
references.citation: Am J Hum Genet. 2000 Mar;66(3):778-89
references.pmid: 10712196
references.citation: Diabetes Care. 2008 Jan;31 Suppl 1:S12-54
references.pmid: 18165335