title: Th17-mediated inflammation in asthma.
abstract: Asthma is a heterogeneous disease with many different phenotypes. Moderate and severe asthma phenotypes have been associated with increased neutrophils and increased Th17 cytokines, IL-17A, IL-17F, and IL-22, in the bronchoalveolar lavage fluid of patients. Th17 cytokines recruit neutrophils to the airway by increasing secretion of epithelial-derived neutrophilic chemokines. In addition, Th17 cytokines also induce mucous cell metaplasia and have pleotropic effects on airway smooth muscle resulting in airway narrowing. The role of Th17 cytokines in regulating Th2 cytokine expression and allergic airway inflammation remains unclear with conflicting reports. However, the role of Th17 cells in asthma will be answered in ongoing clinical trials with therapeutics targeting IL-17A and IL-17 receptor signaling.
authors.affiliation: Vanderbilt University Medical Center, Department of Medicine, Nashville, TN 37232, United States. Electronic address: dawn.newcomb@vanderbilt.edu.
authors.forename: Dawn C
authors.initials: DC
authors.lastname: Newcomb
authors.forename: R Stokes
authors.initials: RS
authors.lastname: Peebles
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D007378:Interleukins / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D000097043:Interleukin-22
chemical_list: D018836:Inflammation Mediators; D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22
references.citation: BMC Pulm Med. 2010 Jan 08;10:3
references.pmid: 20064211
references.citation: Am J Respir Crit Care Med. 2008 Nov 15;178(10):1023-32
references.pmid: 18787221
references.citation: Nat Med. 2008 Mar;14(3):275-81
references.pmid: 18264110
references.citation: J Allergy Clin Immunol. 2005 Sep;116(3):550-7
references.pmid: 16159623
references.citation: Clin Exp Allergy. 2011 Oct;41(10):1447-55
references.pmid: 21722219
references.citation: N Engl J Med. 2011 Sep 22;365(12):1088-98
references.pmid: 21812663
references.citation: Mucosal Immunol. 2012 Mar;5(2):140-9
references.pmid: 22189956
references.citation: J Allergy Clin Immunol. 2001 Sep;108(3):430-8
references.pmid: 11544464
references.citation: J Immunol. 2008 Sep 15;181(6):4089-97
references.pmid: 18768865
references.citation: J Biol Chem. 2007 May 4;282(18):13447-55
references.pmid: 17355969
references.citation: J Allergy Clin Immunol. 2010 Jan;125(1):222-30.e1-4
references.pmid: 20109749
references.citation: Nat Immunol. 2010 Oct;11(10):928-35
references.pmid: 20802484
references.citation: Proc Am Thorac Soc. 2009 May 1;6(3):256-9
references.pmid: 19387026
references.citation: N Engl J Med. 2009 Aug 27;361(9):888-98
references.pmid: 19710487
references.citation: J Allergy Clin Immunol. 2011 Apr;127(4):1006-13.e1-4
references.pmid: 21236478
references.citation: J Allergy Clin Immunol. 2009 May;123(5):1185-7
references.pmid: 19361847
references.citation: J Immunol. 2009 Nov 15;183(10):6236-43
references.pmid: 19841186
references.citation: J Allergy Clin Immunol. 2011 Nov;128(5):1067-76.e1-6
references.pmid: 21794904
references.citation: Lancet. 2007 Oct 20;370(9596):1422-31
references.pmid: 17950857
references.citation: Annu Rev Physiol. 2010;72:495-516
references.pmid: 20148686
references.citation: J Clin Invest. 2010 Dec;120(12):4436-44
references.pmid: 21099117
references.citation: J Exp Med. 2006 Nov 27;203(12):2715-25
references.pmid: 17101734
references.citation: J Exp Med. 2007 Jul 9;204(7):1509-17
references.pmid: 17562814
references.citation: Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63
references.pmid: 21297073
references.citation: Lancet. 2006 Aug 26;368(9537):804-13
references.pmid: 16935691
references.citation: Am J Respir Cell Mol Biol. 2013 Jun;48(6):711-6
references.pmid: 23392574
references.citation: Am J Respir Crit Care Med. 2011 Apr 15;183(8):1007-14
references.pmid: 21057005
references.citation: Ann Allergy Asthma Immunol. 2008 Jul;101(1):1-8; quiz 8-11, 50
references.pmid: 18681077
references.citation: J Biol Chem. 2003 May 9;278(19):17036-43
references.pmid: 12624114
references.citation: J Exp Med. 2010 Oct 25;207(11):2479-91
references.pmid: 20921287
references.citation: Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12
references.pmid: 15130904
references.citation: Respir Med. 2003 Jun;97(6):726-33
references.pmid: 12814161
references.citation: FASEB J. 2012 Dec;26(12):5152-60
references.pmid: 22898922
references.citation: Annu Rev Immunol. 2009;27:485-517
references.pmid: 19132915
references.citation: J Allergy Clin Immunol. 2011 Oct;128(4):800-807.e9
references.pmid: 21719078
references.citation: Am J Respir Crit Care Med. 2010 Apr 15;181(8):788-96
references.pmid: 20056900
references.citation: Nat Med. 2012 Mar 04;18(4):547-54
references.pmid: 22388091
references.citation: J Allergy Clin Immunol. 2003 Jun;111(6):1293-8
references.pmid: 12789232
references.citation: J Immunol. 2012 Feb 1;188(3):1027-35
references.pmid: 22210911
references.citation: J Allergy Clin Immunol. 2011 Apr;127(4):1046-53.e1-2
references.pmid: 21345484
references.citation: Blood. 2013 Mar 28;121(13):2402-14
references.pmid: 23325835
references.citation: Thorax. 2013 Aug;68(8):717-23
references.pmid: 23422214
references.citation: Clin Exp Allergy. 2008 May;38(5):709-50
references.pmid: 18384431
references.citation: J Immunol. 2013 Feb 1;190(3):1056-65
references.pmid: 23293351
references.citation: J Immunol. 2009 May 1;182(9):5317-21
references.pmid: 19380778
references.citation: J Allergy Clin Immunol. 2003 Apr;111(4):677-90; quiz 691
references.pmid: 12704343
references.citation: Nat Immunol. 2005 Nov;6(11):1123-32
references.pmid: 16200070