title: Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors.
abstract: Maturation in central nervous system embryonal tumors is an uncommon phenomenon that is mainly reported in the context of specific histological subgroups of medulloblastoma. In this report we describe two cases of histological maturation in patients with supratentorial primitive neuroectodermal tumor with strikingly different outcomes. We discuss the potential impact of such findings on treatment and outcome.
authors.affiliation: Division of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, Calgary, Alberta, Canada.
authors.forename: Lucie
authors.initials: L
authors.lastname: Lafay-Cousin
authors.forename: Walter
authors.initials: W
authors.lastname: Hader
authors.forename: Xing Chang
authors.initials: XC
authors.lastname: Wei
authors.forename: Robert
authors.initials: R
authors.lastname: Nordal
authors.forename: Douglas
authors.initials: D
authors.lastname: Strother
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hawkins
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Chan
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000473:pathology*; D015173:Supratentorial Neoplasms / Q000188:drug therapy / Q000473:pathology*
keywords: ETANTR; ETMR; maturation; prognosis; sPNET
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