title: Impact on survival of whole-body computed tomography before emergency bleeding control in patients with severe blunt trauma.
abstract: BACKGROUND
  Whole-body computed tomography (CT) has gained importance in the early diagnostic phase of trauma care. However, the diagnostic value of CT for seriously injured patients is not thoroughly clarified. This study assessed whether preoperative CT beneficially affected survival of patients with blunt trauma who required emergency bleeding control.
  
  
  METHODS
  This retrospective study was conducted from January 2004 to December 2010 in two tertiary trauma centers in Japan. The primary inclusion criterion was patients with blunt trauma who required emergency bleeding control (surgery or transcatheter arterial embolization). CT before emergency bleeding control was performed at the attending physician's discretion based on individual patient condition (for example, hemodynamic stability or certain abnormalities in the primary survey). We assessed covariates associated with 28-day mortality with multivariate logistic regression analysis and evaluated standardized mortality ratio (SMR, ratio of observed to predicted mortality by Trauma and Injury Severity Score (TRISS) method) in two subgroups of patients who did or did not undergo CT.
  
  
  RESULTS
  The inclusion criterion was fulfilled by 152 patients with a median Injury Severity Score of 35.3. During the early resuscitation phase, 132 (87%) patients underwent CT and 20 (13%) did not. Severity of injury was significantly higher in the non-CT versus CT group patients. Observed mortality rate was significantly lower in the CT versus non-CT group (18% vs. 80%, P <0.001). Multivariate adjustment for the probability of survival (Ps) by TRISS method confirmed CT as an independent predictor for 28-day mortality (adjusted OR, 7.22; 95% CI, 1.76 to 29.60; P = 0.006). In the subgroup with less severe trauma (TRISS Ps ≥50%), SMR in the CT group was 0.63 (95% CI, 0.23 to 1.03; P = 0.066), indicating no significant difference between observed and predicted mortality in the CT group. In contrast, in the subgroup with more severe trauma (TRISS Ps <50%), SMR was 0.65 (95% CI, 0.41 to 0.90; P = 0.004) only in the CT group, whereas the difference between observed and predicted mortality was not significant in the non-CT group, suggesting a possible beneficial effect of CT on survival only in trauma patients at high risk of death.
  
  
  CONCLUSIONS
  CT performed before emergency bleeding control might be associated with improved survival, especially in severe trauma patients with TRISS Ps of <50%.
authors.forename: Daiki
authors.initials: D
authors.lastname: Wada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakamori
authors.forename: Kazuma
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Kiguchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Tasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kuwagata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimazu
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujimi
mesh_terms: D000328:Adult; D004632:Emergency Medical Services / Q000379:methods* / Q000639:trends; D005260:Female; D006470:Hemorrhage / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000628:therapy; D006801:Humans; D015601:Injury Severity Score; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000639:trends; D014949:Wounds, Nonpenetrating / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000628:therapy; D055815:Young Adult
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