title: Synthesis of the BCDE molecular fragment of azadiradione mediated by titanocene(III).
abstract: A practical, short, and diastereoselective synthesis of the azadiradione BCDE fragment from a readily available starting material is described. The key step was the titanocene(III)-promoted tandem cyclization of unsaturated epoxy nitrile.
authors.affiliation: Departamento de Química Orgánica, Facultad de CC Químicas, and ‡Servicio General de Difracción de Rayos X, Facultad de Ciencias, Universidad de Salamanca , Plaza de los Caídos 1-5, 37008 Salamanca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Mateos
authors.forename: S Encinas
authors.initials: SE
authors.lastname: Madrazo
authors.forename: P Herrero
authors.initials: PH
authors.lastname: Teijón
authors.forename: R Rabanedo
authors.initials: RR
authors.lastname: Clemente
authors.forename: R Rubio
authors.initials: RR
authors.lastname: González
authors.forename: F Sanz
authors.initials: FS
authors.lastname: González
mesh_terms: D002384:Catalysis; D003500:Cyclization; D036701:Limonins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D036701:Limonins; D009570:Nitriles; D009942:Organometallic Compounds; C479321:azadiradione; C406884:titanocene