title: In vitro phytotherapy of vector snails by binary combinations of larvicidal active components in effective control of fascioliasis.
abstract: A food-borne trematode infection fascioliasis is one among common public health problems worldwide. It caused a great economic loss for the human race. Control of snail population below a certain threshold level is one of the important methods in the campaign to reduce the incidence of fascioliasis. The life cycle of the parasite can be interrupted by killing the snail or Fasciola larva redia and cercaria inside of the snail Lymnaea acuminata. In vitro toxicity of different binary combinations (1:1 ratio) of plant-derived larvicidal active components such as citral, ferulic acid, umbelliferone, azadirachtin and allicin against Fasciola redia and cercaria were tested. The mortality of larvae was observed at 2h, 4h, 6h and 8h of treatment. In in vitro condition azadirachtin + allicin (1:1 ratio) was highly toxic against redia and cercaria (8h LC50 0.006 and 0.005 mg/L). Toxicity of citral + ferulic acid was lowest against redia and cercaria larvae.
authors.forename: Kumari
authors.initials: K
authors.lastname: Sunita
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
authors.forename: Vinay Kumar
authors.initials: VK
authors.lastname: Singh
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Singh
mesh_terms: D000818:Animals; D004199:Disease Vectors; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000517:prevention & control; D020128:Inhibitory Concentration 50; D007814:Larva / Q000187:drug effects; D008195:Lymnaea / Q000469:parasitology*; D010936:Plant Extracts / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010936:Plant Extracts
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