title: Isoniazid hepatotoxicity: progress in understanding the immunologic component.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Section of Clinical Pharmacology and Toxicology, Arkansas Children's Hospita, Little Rock, AR.
authors.forename: Laura
authors.initials: L
authors.lastname: James
authors.forename: Dean
authors.initials: D
authors.lastname: Roberts
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D065729:Cytochrome P-450 CYP2C9; D019392:Cytochrome P-450 CYP2E1 / Q000276:immunology*; D051544:Cytochrome P-450 CYP3A / Q000276:immunology*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male
chemical_list: D001323:Autoantibodies; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D007538:Isoniazid
references.citation: Clin Pharmacol Ther. 1975 Jul;18(1):70-9
references.pmid: 1149365
references.citation: Chem Res Toxicol. 2012 Nov 19;25(11):2567-76
references.pmid: 23016703
references.citation: Br J Clin Pharmacol. 1991 Feb;31(2):139-42
references.pmid: 2049229
references.citation: Clin Pharmacol Ther. 2011 Jun;89(6):911-4
references.pmid: 21412230
references.citation: Hepatology. 2003 Apr;37(4):924-30
references.pmid: 12668988
references.citation: Antimicrob Agents Chemother. 2001 Feb;45(2):382-92
references.pmid: 11158730
references.citation: Gastroenterology. 1975 Aug;69(2):289-302
references.pmid: 1150039