title: Pharmacokinetics of CNT-based drug delivery systems.
abstract: Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood. Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14., 3rd Sec, Ren Min Nan Road, Chengdu 610041, P.R. China. yunfenglin@scu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Ye
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Luo
authors.forename: Qiang
authors.initials: Q
authors.lastname: Peng
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Cai
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000042:Absorption; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics*; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations