title: A novel tandem sequence to pyrrole syntheses by 5-endo-dig cyclization of 1,3-enynes with amines.
abstract: The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati-781039, Assam, India.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Bharathiraja
authors.forename: Sekarpandi
authors.initials: S
authors.lastname: Sakthivel
authors.forename: Mani
authors.initials: M
authors.lastname: Sengoden
authors.forename: Tharmalingam
authors.initials: T
authors.lastname: Punniyamurthy
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000588:Amines; D011758:Pyrroles; D007455:Iodine