title: Role of Hippo signaling in cancer stem cells.
abstract: Cancer stem cells (CSCs) have been proposed and evidenced as the initiator of tumor formation and the seeds of metastases. Thereby, the molecular mechanisms regarding modulation of CSCs have been widely explored, aimed to improve treatment for cancer patients. Recent progress has highlighted the effects of Hippo signaling in tumorigenesis and cancer development, including its crucial role in CSC regulation. Although the kernel Hippo signaling cascade has been well studied, its upstream inputs and downstream transcriptional regulation still remain elusive. In this review, we summarize the current understanding of the mechanism and regulatory function of Hippo signaling in CSCs, with emphasis on its possible roles in regulation of CSC self-renewal, differentiation and tumorigenesis.
authors.affiliation: Department of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Hao
authors.forename: Yueling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dian
authors.initials: D
authors.lastname: Jing
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D000090683:Hippo Signaling Pathway; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D017346:Protein Serine-Threonine Kinases