title: Association between FAT Gene and Schizophrenia in the Korean Population.
abstract: OBJECTIVE
  The aim of this study was to investigate the genetic association of the FAT gene with schizophrenia in the Korean population, as well as analyzing the association of FAT gene with clinical variables.
  
  
  METHODS
  Four variants within the FAT gene were investigated in 189 patients with schizophrenia and 119 healthy controls (rs2306987 A/C, rs2306990 T/C, rs2637777 G/T, and rs2304865 G/C).
  
  
  RESULTS
  Significant association at the rs273777 with schizophrenia was observed; however, rs2306987, rs2306990, and rs2304865 were not associated with schizophrenia. Haplotype analyses revealed that the haplotype A/T/T/G was associated with a significantly protective effect. Sliding window analysis (rs2637777 G/T and rs2304865 G/C) revealed the more common T/G haplotype, included in the A/T/T/G protective combination, showed a small protective effect, in particular the effect was due to the rs273777 T variant (minor allele).
  
  
  CONCLUSIONS
  The present finding suggests that FAT polymorphism may play a putative role in the susceptibility to schizophrenia in the Korean population. Further studies using a larger number of subjects should be performed to determine whether the FAT gene polymorphism may be truly involved in the development of schizophrenia.
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea.
authors.forename: Young-Eun
authors.initials: YE
authors.lastname: Jung
authors.forename: Tae-Youn
authors.initials: TY
authors.lastname: Jun
keywords: Association; Cadherins; Korean; Polymorphism; Schizophrenia
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