title: The association of fetal and early childhood growth with adult mental distress: evidence from the johns hopkins collaborative perinatal study birth cohort.
abstract: OBJECTIVE
  Early childhood physical growth may have an impact on the development of adult mental distress. The primary objectives were to (1) assess the association of early growth in weight (adjusted for height) with adult mental distress, and (2) determine if specific sub-types, or patterns, of early physical growth are associated with adult mental distress.
  
  
  METHODS
  Subjects were all Johns Hopkins Collaborative Perinatal Study cohort subjects with complete birth size information that successfully completed the Pathways to Adulthood follow-up in early adulthood. Variability in the timing of growth in weight adjusted for height from birth to age 7.5 years was taken into account using a non-hierarchical linear model. Two critical periods of growth were considered as tertiles of change in weight adjusted for height from birth to age 7 and birth to age 1 year. Mental distress in adulthood (ages 29-32) was measured using the General Health Questionnaire (GHQ-28).
  
  
  RESULTS
  Small for gestational age subjects were at increased risk of later mental distress, but not uniformly so. Those born with low weight and length for gestational age were a distinct subgroup of those born small for gestational age, and had unique patterns of risk for adult mental distress when early growth was considered.
  
  
  CONCLUSIONS
  Acceleration and deceleration in weight for height change is associated with mental distress over multiple periods of early life and acts differentially between those periods. Furthermore, the association of early childhood growth with the likelihood of adult mental distress is dependent on prenatal growth.
authors.affiliation: Battelle Center for Analytics and Public Health , Arlington, VA , USA.
authors.forename: Aaron A
authors.initials: AA
authors.lastname: Alford
keywords: depression; developmental origins of health and disease; early growth; fetal growth retardation; mental distress
references.citation: Physiol Rev. 2005 Apr;85(2):571-633
references.pmid: 15788706
references.citation: Int J Epidemiol. 2001 Dec;30(6):1330-1
references.pmid: 11821341
references.citation: BMJ. 2002 Oct 5;325(7367):749
references.pmid: 12364303
references.citation: Br Med Bull. 2001;60:5-20
references.pmid: 11809615
references.citation: Clin Sci (Lond). 1998 Aug;95(2):115-28
references.pmid: 9680492
references.citation: BMJ. 2000 Apr 8;320(7240):967-71
references.pmid: 10753147
references.citation: Biol Neonat. 1963;5:215-65
references.pmid: 14081642
references.citation: Br J Obstet Gynaecol. 1977 Mar;84(3):165-74
references.pmid: 843490
references.citation: Lancet. 2004 Sep 25-Oct 1;364(9440):1135-40
references.pmid: 15451220
references.citation: J Physiol. 2003 Apr 15;548(Pt 2):519-26
references.pmid: 12626675
references.citation: Med Clin North Am. 2006 Jul;90(4):573-91
references.pmid: 16843763
references.citation: Curr Opin Obstet Gynecol. 2005 Apr;17(2):135-42
references.pmid: 15758604
references.citation: Lancet. 2004 May 15;363(9421):1642-5
references.pmid: 15145640
references.citation: Obstet Gynecol Surv. 1982 Aug;37(8):499-506
references.pmid: 7050797
references.citation: J Clin Pathol. 1972 Oct;25(10):867-71
references.pmid: 4646298
references.citation: Ultrasound Obstet Gynecol. 2003 Mar;21(3):256-61
references.pmid: 12666220
references.citation: Soc Psychiatry Psychiatr Epidemiol. 2004 Aug;39(8):613-7
references.pmid: 15300371
references.citation: J Clin Endocrinol Metab. 2006 Jun;91(6):2153-8
references.pmid: 16537681
references.citation: J Pediatr. 1997 Jan;130(1):95-102
references.pmid: 9003857
references.citation: Br J Psychiatry. 2001 Nov;179:450-5
references.pmid: 11689404
references.citation: Am J Obstet Gynecol. 1976 May 1;125(1):55-60
references.pmid: 1275014
references.citation: Obstet Gynecol. 1979 Aug;54(2):211-9
references.pmid: 460756
references.citation: Psychol Med. 1979 Feb;9(1):139-45
references.pmid: 424481
references.citation: BJOG. 2004 Feb;111(2):113-9
references.pmid: 14723747
references.citation: Clin Exp Pharmacol Physiol. 2001 Nov;28(11):967-70
references.pmid: 11703407
references.citation: Int J Epidemiol. 2001 Dec;30(6):1325-30
references.pmid: 11821340
references.citation: Early Hum Dev. 2003 Oct;74(1):13-26
references.pmid: 14512178