title: The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread.
abstract: The role of clathrin in pathogen entry has received much attention and has highlighted the adaptability of clathrin during internalization. Recent studies have now uncovered additional roles for clathrin and have put the spotlight on its role in pathogen spread. Here, we discuss the manipulation of clathrin by pathogens, with specific attention to the processes that occur at the plasma membrane. In the majority of cases, both clathrin and the actin cytoskeleton are hijacked, so we also examine the interplay between these two systems and their role during pathogen internalization, egress and spread.
authors.affiliation: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.
authors.forename: Ashley C
authors.initials: AC
authors.lastname: Humphries
authors.forename: Michael
authors.initials: M
authors.lastname: Way
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism / Q000382:microbiology / Q000821:virology; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001422:Bacterial Adhesion; D002462:Cell Membrane / Q000378:metabolism / Q000382:microbiology / Q000821:virology; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D054884:Host-Pathogen Interactions; D021381:Protein Transport; D012763:Shigella flexneri / Q000502:physiology; D014616:Vaccinia virus / Q000502:physiology; D053586:Virus Internalization; D057074:Virus Release; D014779:Virus Replication
chemical_list: D000199:Actins; D002966:Clathrin
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