title: Homoisoflavones as the antioxidants responsible from bulbs of Scilla scilloides.
abstract: Scilla scilloides Druce has been used as a folk medicine to treat dermal inflammation; however, the medicinal property of this plant remains to be entirely clarified. The ethyl acetate extract prepared from bulbs of S. scilloides exhibited antioxidative activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and nitric oxide (NO) scavenging assays. Nine homoisoflavones (1-9) yielded from this extract were further examined for their antioxidative activities. Among these chemicals tested, five homoisoflavones (1-3, 5 and 7), six homoisoflavones (1-3 and 5-7) and two homoisoflavones (4 and 5) resulted in showing higher activities than the others in DPPH radical, H2O2 and NO scavenging assays, respectively. Calculated EC50 values indicate 3 as the strongest in the DPPH radical scavenging analysis. These results may indicate a potential role of S. scilloides for its medicinal use and homoisoflavones as the antioxidants responsible.
authors.affiliation: a Department of Bioscience , School of Agriculture, Tokai University , Kawayo, Minamiaso, Aso, Kumamoto , 869-1404 , Japan.
authors.forename: Youichirou
authors.initials: Y
authors.lastname: Nishida
authors.forename: Kensuke
authors.initials: K
authors.lastname: Wada
authors.forename: Daiki
authors.initials: D
authors.lastname: Toyohisa
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.forename: Shin
authors.initials: S
authors.lastname: Yasuda
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D007529:Isoflavones / Q000737:chemistry*; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D031445:Scilla / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D007529:Isoflavones; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl