title: The clinical burden and predictors of sequelae following invasive meningococcal disease in Australian children.
abstract: Of 109 children admitted to a tertiary paediatric hospital with a diagnosis of invasive meningococcal disease from 2000-2011, 37.6% (n = 41) developed sequelae; for serogroup B, 41.3% developed sequelae. Independent predictors of sequelae included: fever ≥ 39 °C on hospital presentation [odds ratio (OR): 4.5; P = 0.012] and a diagnosis of septicemia with meningitis compared with septicemia alone (OR: 15.5; P < 0.001) and meningitis alone (OR: 7.8; P = 0.002).
authors.affiliation: From the *School of Population Health/Paediatrics and Reproductive Health, University of Adelaide; †Vaccinology and Immunology Research Trials Unit (VIRTU), Women's and Children's Hospital; ‡Vaccinology and Immunology Research Trials Unit (VIRTU), Women's and Children's Hospital, North Adelaide; §Data Management & Analysis Centre, Discipline of Public Health, University of Adelaide; ¶Discipline of Public Health, University of Adelaide; and ‖Career Development Fellow, Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Michelle
authors.initials: M
authors.lastname: Clarke
authors.forename: Natalie
authors.initials: N
authors.lastname: Thomas
authors.forename: Stuart
authors.initials: S
authors.lastname: Howell
authors.forename: Hossein Haji Ali
authors.initials: HH
authors.lastname: Afzali
authors.forename: Helen
authors.initials: H
authors.lastname: Marshall
mesh_terms: D000293:Adolescent; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever; D006801:Humans; D007022:Hypotension; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008585:Meningitis, Meningococcal; D008589:Meningococcal Infections / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis