title: Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells.
abstract: BACKGROUND
  Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under stimulation by total Porphyromonas gingivalis antigens and purified recombinant P. gingivalis HmuY protein.
  
  
  RESULTS
  CD3+ T cells derived from CP patients and stimulated with HmuY expressed higher levels of Bcl-2 compared to identical cells stimulated with P. gingivalis crude extract or cells derived from NP control subjects (p = 0.043).
  
  
  CONCLUSIONS
  The authors hypothesize that P. gingivalis HmuY plays a role in the pathogenesis of chronic periodontitis, possibly by reducing or delaying apoptosis in T cells through a pathway involving the Bcl-2 protein.
authors.affiliation: Department of Immunology, Federal University of Bahia, Salvador, BA, Brazil. pauloccf@yahoo.com.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Carvalho-Filho
authors.forename: Soraya C
authors.initials: SC
authors.lastname: Trindade
authors.forename: Teresa
authors.initials: T
authors.lastname: Olczak
authors.forename: Geraldo P
authors.initials: GP
authors.lastname: Sampaio
authors.forename: Milton G
authors.initials: MG
authors.lastname: Oliveira-Neto
authors.forename: Heidiane A
authors.initials: HA
authors.lastname: Santos
authors.forename: Bianca F P
authors.initials: BF
authors.lastname: Pereira
authors.forename: Lilia
authors.initials: L
authors.lastname: Moura-Costa
authors.forename: Márcia T
authors.initials: MT
authors.lastname: Xavier
authors.forename: Roberto
authors.initials: R
authors.lastname: Meyer
mesh_terms: D000328:Adult; D001426:Bacterial Proteins / Q000378:metabolism*; D017252:CD3 Complex / Q000032:analysis*; D005260:Female; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D013601:T-Lymphocytes / Q000737:chemistry / Q000382:microbiology*; D055815:Young Adult; D019014:fas Receptor / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D017252:CD3 Complex; C491901:FAS protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor
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