title: Association between the RAD51 135 G>C polymorphism and risk of cancer: a meta-analysis of 19,068 cases and 22,630 controls.
abstract: BACKGROUND
  RAD51 135G>C can modify promoter activity and the penetrance of BRCA1/2 mutations, which plays vital roles in the etiology of various cancer. To date, previous published data on the association between RAD51 135G>C polymorphism and cancer risk remained controversial. Recent meta-analysis only analyzed RAD51 135G>C polymorphism with breast cancer risk, but the results were also inconsistent.
  
  
  METHODS
  A meta-analysis based on 39 case-control studies was performed to investigate the association between cancer susceptibility and RAD51 135G>C. Odds ratios (OR) with 95% confidence intervals (CIs) were used to assess the association in different inheritance models. Heterogeneity among studies was tested and sensitivity analysis was applied.
  
  
  RESULTS
  Overall, no significant association was found between RAD51 135G>C polymorphism and cancer susceptibility in any genetic model. In further stratified analysis, significantly elevated breast cancer risk was observed in BRCA2 mutation carriers (recessive model: OR = 4.88, 95% CI = 1.10-21.67; additive model: OR = 4.92, 95% CI = 1.11-21.83).
  
  
  CONCLUSIONS
  This meta-analysis suggests that RAD51 variant 135C homozygote is associated with elevated breast cancer risk among BRCA2 mutation carriers. Moreover, our work also points out the importance of new studies for RAD51 135G>C association in acute myeloid leukemia, especially in Caucasians, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the RAD51 135G>C polymorphism in cancer development.
authors.affiliation: Shanxi Zhendong Pharmaceutical Co. Ltd., Changzhi, Shanxi Province, China ; Research Center of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.forename: An-Ping
authors.initials: AP
authors.lastname: Li
authors.forename: Yong-Lin
authors.initials: YL
authors.lastname: Cai
authors.forename: Na
authors.initials: N
authors.lastname: Xu
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Sun
authors.forename: Bing-Yi
authors.initials: BY
authors.lastname: Wu
mesh_terms: D016022:Case-Control Studies; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051135:Rad51 Recombinase / Q000235:genetics*
chemical_list: D051135:Rad51 Recombinase
references.citation: Breast Cancer Res Treat. 2011 Feb;125(3):827-35
references.pmid: 20640595
references.citation: J Obstet Gynaecol Res. 2012 Jun;38(6):918-24
references.pmid: 22487057
references.citation: Dis Markers. 2001;17(2):89-98
references.pmid: 11673655
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Trends Biochem Sci. 1998 Jul;23(7):247-51
references.pmid: 9697414
references.citation: Breast Cancer Res Treat. 2005 Nov;94(2):105-9
references.pmid: 16261408
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3232-6
references.pmid: 11248061
references.citation: Breast Cancer Res Treat. 2007 Jun;103(2):209-17
references.pmid: 17063276
references.citation: J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72
references.pmid: 11058619
references.citation: Breast. 2006 Dec;15(6):754-61
references.pmid: 16713266
references.citation: Mol Cell Biol. 2004 Nov;24(21):9305-16
references.pmid: 15485900
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Nucleic Acids Res. 1998 Jun 15;26(12):2859-64
references.pmid: 9611228
references.citation: Nat Genet. 1993 Jul;4(3):239-43
references.pmid: 8358431
references.citation: DNA Cell Biol. 2012 Feb;31(2):199-210
references.pmid: 21740187
references.citation: J Epidemiol. 2005 Jun;15 Suppl 2:S157-67
references.pmid: 16127228
references.citation: Hum Mol Genet. 2002 Jun 1;11(12):1399-407
references.pmid: 12023982
references.citation: Pol J Pathol. 2005;56(4):161-5
references.pmid: 16477874
references.citation: Toxicol Appl Pharmacol. 2002 Nov 15;185(1):64-73
references.pmid: 12460738
references.citation: Ann Oncol. 2007 Sep;18(9):1523-8
references.pmid: 17761709
references.citation: Eur J Cancer. 2009 Mar;45(5):837-42
references.pmid: 19071013
references.citation: Cancer Genet Cytogenet. 2007 Oct 1;178(1):65-9
references.pmid: 17889711
references.citation: Exp Oncol. 2006 Jun;28(2):156-9
references.pmid: 16837909
references.citation: Breast Cancer Res Treat. 2011 Jan;125(1):157-61
references.pmid: 20454923
references.citation: Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Nov;39(6):973-5
references.pmid: 19253839
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3482-9
references.pmid: 19064565
references.citation: J Med Virol. 2011 Nov;83(11):1892-9
references.pmid: 21915862
references.citation: Breast Cancer Res Treat. 2010 Jan;119(1):87-93
references.pmid: 19214744
references.citation: Breast Cancer Res Treat. 2011 Apr;126(2):365-71
references.pmid: 20461453
references.citation: Pol Merkur Lekarski. 2009 May;26(155):455-7
references.pmid: 19606696
references.citation: Oncogene. 1996 Mar 7;12(5):973-8
references.pmid: 8649814
references.citation: Dokl Biol Sci. 2006 Jan-Feb;406:66-9
references.pmid: 16572816
references.citation: Clin Cancer Res. 2004 Apr 15;10(8):2675-80
references.pmid: 15102670
references.citation: Mol Biol Rep. 2011 Feb;38(2):1163-70
references.pmid: 20602259
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: Nat Genet. 2001 Mar;27(3):247-54
references.pmid: 11242102
references.citation: Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):457-9
references.pmid: 12750242
references.citation: PLoS Genet. 2007 Mar 16;3(3):e42
references.pmid: 17367212
references.citation: J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):357-64
references.pmid: 11162945
references.citation: J Investig Med. 2011 Oct;59(7):1124-30
references.pmid: 21725251
references.citation: Lancet. 1997 Oct 18;350(9085):1182
references.pmid: 9343537
references.citation: DNA Repair (Amst). 2003 Sep 18;2(9):1015-28
references.pmid: 12967658
references.citation: Leuk Res. 2011 Aug;35(8):1020-6
references.pmid: 21296419
references.citation: Int J Hyg Environ Health. 2007 Dec;210(6):671-678
references.pmid: 17157560
references.citation: Cancer Lett. 2005 Mar 10;219(2):125-35
references.pmid: 15723711
references.citation: Leuk Res. 2007 Feb;31(2):169-74
references.pmid: 16890287
references.citation: Mutat Res. 2008 Oct 30;656(1-2):74-81
references.pmid: 18768166
references.citation: Breast Cancer Res Treat. 2010 Aug;122(3):813-22
references.pmid: 20054644
references.citation: Radiother Oncol. 2002 Aug;64(2):131-40
references.pmid: 12242122
references.citation: Fam Cancer. 2008;7(3):233-44
references.pmid: 18283561
references.citation: Clin Cancer Res. 2005 Jun 15;11(12):4620-6
references.pmid: 15958648
references.citation: Acta Biochim Pol. 2003;50(1):249-53
references.pmid: 12673366
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):270-5
references.pmid: 17301259
references.citation: Mutat Res. 2008 Dec 15;648(1-2):65-72
references.pmid: 18977234
references.citation: Exp Mol Pathol. 2010 Dec;89(3):358-66
references.pmid: 20804747
references.citation: Cancer Lett. 2006 Aug 18;240(1):17-28
references.pmid: 16223564
references.citation: Leukemia. 2008 Feb;22(2):265-72
references.pmid: 18033323
references.citation: Pol J Pathol. 2011 Sep;62(3):157-62
references.pmid: 22102073
references.citation: Oncogene. 2004 Jan 15;23(2):546-53
references.pmid: 14724582
references.citation: J Natl Cancer Inst. 1981 Jun;66(6):1191-308
references.pmid: 7017215
references.citation: Breast Cancer Res Treat. 2010 Dec;124(3):765-9
references.pmid: 20396943
references.citation: Br J Cancer. 2013 Jul 9;109(1):68-75
references.pmid: 23807173
references.citation: Oral Oncol. 2000 May;36(3):256-63
references.pmid: 10793327
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):319-23
references.pmid: 15734952
references.citation: Urol Oncol. 2011 Nov-Dec;29(6):641-6
references.pmid: 19914098
references.citation: Exp Mol Pathol. 2009 Aug;87(1):32-5
references.pmid: 19426727
references.citation: Oral Dis. 2014 May;20(4):416-24
references.pmid: 23796347
references.citation: Genomics. 1994 Jan 15;19(2):376-8
references.pmid: 8188269
references.citation: Mol Biol Rep. 2011 Apr;38(4):2849-54
references.pmid: 21104022
references.citation: Genet Mol Res. 2005 Dec 30;4(4):771-82
references.pmid: 16475125
references.citation: Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Jun;17(3):523-8
references.pmid: 19549356
references.citation: Pol Merkur Lekarski. 2006 Jul;21(121):55-8
references.pmid: 17007294
references.citation: Int J Cancer. 2005 Nov 20;117(4):611-8
references.pmid: 15924337
references.citation: Pol J Pathol. 2010;61(4):206-12
references.pmid: 21290343
references.citation: Carcinogenesis. 2007 Aug;28(8):1788-93
references.pmid: 17557904
references.citation: Am J Hum Genet. 2007 Dec;81(6):1186-200
references.pmid: 17999359
references.citation: Br J Cancer. 2004 May 17;90(10):2002-5
references.pmid: 15138485
references.citation: Nucleic Acids Res. 2001 Nov 1;29(21):4352-60
references.pmid: 11691922
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):1016-9
references.pmid: 18398049
references.citation: Gut. 2004 Jun;53(6):871-6
references.pmid: 15138216
references.citation: Breast Cancer Res Treat. 2011 Jan;125(2):529-35
references.pmid: 20623332
references.citation: Carcinogenesis. 2007 May;28(5):988-94
references.pmid: 17118968
references.citation: Tohoku J Exp Med. 2011;224(3):201-8
references.pmid: 21701125
references.citation: Scand J Urol Nephrol Suppl. 2000;(205):105-15
references.pmid: 11144890
references.citation: Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):955-60
references.pmid: 11535547
references.citation: Mutat Res. 2006 Oct 10;601(1-2):83-91
references.pmid: 16843501
references.citation: Cancer Res. 2004 Aug 15;64(16):5560-3
references.pmid: 15313891
references.citation: J Biosci. 2005 Feb;30(1):93-102
references.pmid: 15824445
references.citation: Cancer Res. 1988 Jun 1;48(11):3282-7
references.pmid: 3365707
references.citation: Mol Biol Rep. 2012 Jan;39(1):527-34
references.pmid: 21559836
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120