title: Dual antiplatelet therapy dilemmas: duration and choice of antiplatelets in acute coronary syndromes.
abstract: Dual antiplatelet therapy (DAPT) is a key component of therapy for acute coronary syndromes managed with and without percutaneous coronary intervention. Recent advances have given patients a wider variety of therapeutic options including the use of combinations of agents, dosing strategies, and durations of therapy. The optimal regimen minimizes thrombotic risk without increasing the risk of bleeding. Choosing the best therapy for each patient is an individualized dilemma that requires new, evidence-based tools to support regimen decision-making.
authors.affiliation: The Zena and Michael A. Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Tomey
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D016527:Drug Costs / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D010979:Platelet Function Tests / Q000379:methods; D017410:Practice Guidelines as Topic; D018570:Risk Assessment / Q000379:methods
chemical_list: D010975:Platelet Aggregation Inhibitors
references.citation: N Engl J Med. 2001 Aug 16;345(7):494-502
references.pmid: 11519503
references.citation: Circulation. 2012 Aug 14;126(7):875-910
references.pmid: 22800849
references.citation: JACC Cardiovasc Interv. 2013 Feb;6(2):158-65
references.pmid: 23428007
references.citation: Circulation. 2000 Oct 24;102(17):2031-7
references.pmid: 11044416
references.citation: N Engl J Med. 2010 Sep 2;363(10):930-42
references.pmid: 20818903
references.citation: Circulation. 2011 Apr 26;123(16):1745-56
references.pmid: 21482968
references.citation: N Engl J Med. 2005 Mar 24;352(12):1179-89
references.pmid: 15758000
references.citation: JACC Cardiovasc Interv. 2008 Dec;1(6):649-53
references.pmid: 19463379
references.citation: Lancet. 2001 Aug 18;358(9281):527-33
references.pmid: 11520521
references.citation: J Am Coll Cardiol. 2010 Jun 8;55(23):2556-66
references.pmid: 20513595
references.citation: N Engl J Med. 2009 Sep 10;361(11):1045-57
references.pmid: 19717846
references.citation: J Thromb Haemost. 2013 Jan;11(1):81-91
references.pmid: 23137413
references.citation: J Am Coll Cardiol. 2009 Mar 10;53(10):849-56
references.pmid: 19264241
references.citation: Circulation. 2010 Jan 5;121(1):71-9
references.pmid: 20026770
references.citation: N Engl J Med. 2012 Oct 4;367(14):1297-309
references.pmid: 22920930
references.citation: Circulation. 2013 Jan 29;127(4):e362-425
references.pmid: 23247304
references.citation: JACC Cardiovasc Imaging. 2011 Nov;4(11):1217-9
references.pmid: 22093273
references.citation: Circ Cardiovasc Interv. 2009 Aug;2(4):285-93
references.pmid: 20031730
references.citation: JAMA. 2005 Sep 14;294(10):1224-32
references.pmid: 16143698
references.citation: Am Heart J. 2011 Oct;162(4):733-9
references.pmid: 21982667
references.citation: N Engl J Med. 2009 Jan 22;360(4):354-62
references.pmid: 19106084
references.citation: Circulation. 2000 Jun 6;101(22):2557-67
references.pmid: 10840005
references.citation: N Engl J Med. 2012 Nov 29;367(22):2100-9
references.pmid: 23121439
references.citation: JAMA. 2000 Aug 16;284(7):835-42
references.pmid: 10938172
references.citation: Eur Heart J. 2013 Jan;34(3):220-8
references.pmid: 22719022
references.citation: N Engl J Med. 1998 Dec 3;339(23):1665-71
references.pmid: 9834303
references.citation: N Engl J Med. 2007 Nov 15;357(20):2001-15
references.pmid: 17982182
references.citation: JAMA. 2011 Dec 28;306(24):2704-14
references.pmid: 22203539
references.citation: Am Heart J. 2010 Dec;160(6):1035-41, 1041.e1
references.pmid: 21146655
references.citation: J Am Coll Cardiol. 2012 Jun 12;59(24):2159-64
references.pmid: 22520250
references.citation: N Engl J Med. 2012 Jan 5;366(1):20-33
references.pmid: 22077816
references.citation: J Am Coll Cardiol. 2012 Jul 17;60(3):193-9
references.pmid: 22789884
references.citation: JAMA. 2002 Nov 20;288(19):2411-20
references.pmid: 12435254
references.citation: N Engl J Med. 2010 May 6;362(18):1663-74
references.pmid: 20445180
references.citation: Circulation. 2007 Feb 13;115(6):813-8
references.pmid: 17224480
references.citation: BMJ. 2006 Nov 25;333(7578):1091
references.pmid: 17032691
references.citation: Circulation. 2009 Jun 30;119(25):3215-22
references.pmid: 19528337
references.citation: JACC Cardiovasc Interv. 2011 Oct;4(10):1119-28
references.pmid: 22017938
references.citation: Am J Cardiol. 2011 Apr 15;107(8):1136-43
references.pmid: 21324428
references.citation: JAMA. 2012 Nov 7;308(17):1785-94
references.pmid: 23117779
references.citation: N Engl J Med. 2012 Apr 12;366(15):1404-13
references.pmid: 22443427
references.citation: Circulation. 2011 May 10;123(18):2022-60
references.pmid: 21444889
references.citation: JAMA. 2011 Mar 16;305(11):1097-105
references.pmid: 21406646
references.citation: Circulation. 2012 Jan 24;125(3):505-13
references.pmid: 22179532
references.citation: Circ Cardiovasc Interv. 2009 Oct;2(5):401-8
references.pmid: 20031749
references.citation: Lancet. 2005 Nov 5;366(9497):1607-21
references.pmid: 16271642
references.citation: JAMA. 2011 Dec 28;306(24):2727-8
references.pmid: 22203545
references.citation: Circulation. 2009 Apr 14;119(14):1873-82
references.pmid: 19332461