title: Electrocardiographic abnormalities and elevated cTNT at admission for intracerebral hemorrhage: predictors for survival?
abstract: BACKGROUND
  Cerebrovascular lesions are often associated with electrocardiographic (ECG) abnormalities. The main purpose of this work was to investigate the prognostic value of ECG abnormalities and/or elevated cardiac troponin (cTNT) on admission in patients with nontraumatic intracerebral hemorrhage (ICH).
  
  
  METHODS
  Ninety-seven consecutive patients with ICH were included. The predictive value of ECG abnormalities and increased TNT on survival were evaluated using Cox proportional hazard model.
  
  
  RESULTS
  The most frequently observed ECG abnormalities were the presence of a Q wave (39.6%), followed by prolonged QTc (>0.44 s; 35.4%), which was an independent predictor for long-term mortality (P = 0.019). No difference in QTc was observed between patients with right versus left ICH. Increased cTNT levels at admission had no prognostic value.
  
  
  CONCLUSIONS
  Various ECG changes were common in patients presenting with an ICH, but only prolonged QTc was found to be an independent predictor of poor survival during follow-up after ICH.
authors.affiliation: Stroke Unit, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
authors.forename: Clara
authors.initials: C
authors.lastname: Hjalmarsson
authors.forename: Lennart
authors.initials: L
authors.lastname: Bergfeldt
authors.forename: Lena
authors.initials: L
authors.lastname: Bokemark
authors.forename: Karin
authors.initials: K
authors.lastname: Manhem
authors.forename: Björn
authors.initials: B
authors.lastname: Andersson
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000401:mortality / Q000503:physiopathology*; D015331:Cohort Studies; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D014336:Troponin / Q000097:blood*
chemical_list: D014336:Troponin
keywords: ECG; QTc; cTNT; intracerebral hemorrhage; stroke prognosis
references.citation: Arch Neurol. 1995 Dec;52(12):1193-200
references.pmid: 7492294
references.citation: J Am Coll Cardiol. 2004 Feb 18;43(4):565-71
references.pmid: 14975464
references.citation: Eur Heart J. 1985 Nov;6 Suppl D:81-3
references.pmid: 4085519
references.citation: Am J Cardiol. 2008 Sep 1;102(5):632-4
references.pmid: 18721527
references.citation: J Anesth. 2001;15(2):74-7
references.pmid: 14566526
references.citation: Prog Cardiovasc Dis. 1993 Nov-Dec;36(3):245-60
references.pmid: 8234777
references.citation: J Neurosurg Anesthesiol. 1999 Jul;11(3):163-6
references.pmid: 10414669
references.citation: Neurology. 2006 May 9;66(9):1330-4
references.pmid: 16682662
references.citation: Stroke. 1999 Jul;30(7):1307-11
references.pmid: 10390300
references.citation: Neurocrit Care. 2010 Feb;12(1):50-5
references.pmid: 19813104
references.citation: Eur Heart J. 1999 Feb;20(4):278-84
references.pmid: 10099922
references.citation: Am J Emerg Med. 2004 May;22(3):141-4
references.pmid: 15138946
references.citation: Am J Cardiol. 1988 Jan 1;61(1):83-7
references.pmid: 3337022
references.citation: Am Heart J. 1980 Mar;99(3):294-300
references.pmid: 7355693
references.citation: J Clin Epidemiol. 1988;41(2):105-14
references.pmid: 3335877
references.citation: Acta Neurochir (Wien). 1988;91(1-2):12-20
references.pmid: 3394542
references.citation: J Am Coll Cardiol. 2009 Mar 17;53(11):982-91
references.pmid: 19281931
references.citation: Cerebrovasc Dis. 2012;34(1):86-92
references.pmid: 22814203
references.citation: J Am Coll Cardiol. 2000 Sep;36(3):959-69
references.pmid: 10987628
references.citation: Am J Cardiol. 1993 Aug 26;72(6):14B-16B
references.pmid: 8256749
references.citation: J Am Coll Cardiol. 1996 Jan;27(1):76-83
references.pmid: 8522713
references.citation: J Neurol. 1995 May;242(5):313-8
references.pmid: 7643140
references.citation: J Neurol Sci. 2005 Jul 15;234(1-2):99-103
references.pmid: 15935384
references.citation: Diabet Med. 2001 Mar;18(3):199-205
references.pmid: 11318840
references.citation: Mayo Clin Proc. 2006 Feb;81(2):192-6
references.pmid: 16471073
references.citation: Am J Emerg Med. 2012 May;30(4):545-52
references.pmid: 21450435
references.citation: Intensive Care Med. 2003 Jun;29(6):933-938
references.pmid: 12734651
references.citation: Jpn Heart J. 1999 Jul;40(4):405-11
references.pmid: 10611905
references.citation: Stroke. 1989 Jul;20(7):864-70
references.pmid: 2749846
references.citation: Circulation. 1960 Jun;21:1160-75
references.pmid: 13849070
references.citation: Cerebrovasc Dis. 2002;14(2):67-76
references.pmid: 12187009
references.citation: Curr Opin Neurol. 1994 Feb;7(1):20-4
references.pmid: 8173672
references.citation: Acta Neurochir Suppl. 2011;111:353-6
references.pmid: 21725781
references.citation: Angiology. 1990 Sep;41(9 Pt 1):681-6
references.pmid: 2221470