title: Oral contrast enhances the resolution of in-life NIS reporter gene imaging.
abstract: Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach and enhances signal detection from radiotracer uptake in NIS-transduced organs.
authors.affiliation: Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: L
authors.initials: L
authors.lastname: Suksanpaisan
authors.forename: L
authors.initials: L
authors.lastname: Pham
authors.forename: S
authors.initials: S
authors.lastname: McIvor
authors.forename: S J
authors.initials: SJ
authors.lastname: Russell
authors.forename: K-W
authors.initials: KW
authors.lastname: Peng
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000008:administration & dosage; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D018014:Gene Transfer Techniques; D017930:Genes, Reporter / Q000187:drug effects*; D064593:Heterografts; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D013270:Stomach / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D027981:Symporters / Q000235:genetics* / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D000099209:Sodium-Iodide Symporters
chemical_list: D001466:Barium Sulfate; D003287:Contrast Media; D007457:Iodine Radioisotopes; D027981:Symporters; D000099209:Sodium-Iodide Symporters
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