title: Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice.
abstract: Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation.
authors.affiliation: Neurovascular Research Laboratory, Institut de Recerca, Vall d'Hebron Hospital, Universitat Autònoma de Barcelona, Pg Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Hernández-Guillamon
authors.forename: Laura
authors.initials: L
authors.lastname: Ortega
authors.forename: Cristina
authors.initials: C
authors.lastname: Merino-Zamorano
authors.forename: Mireia
authors.initials: M
authors.lastname: Campos-Martorell
authors.forename: Anna
authors.initials: A
authors.lastname: Rosell
authors.forename: Joan
authors.initials: J
authors.lastname: Montaner
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology*; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005947:Glucose / Q000172:deficiency*; D007036:Hypothermia, Induced / Q000379:methods*; D000860:Hypoxia; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D051379:Mice; D009474:Neurons / Q000502:physiology*; D009924:Organ Culture Techniques; D018709:Statistics, Nonparametric
chemical_list: D007770:L-Lactate Dehydrogenase; D005947:Glucose
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