title: Metabolic rather than body composition measurements are associated with lower serum natriuretic peptide concentrations in normal weight and obese men.
abstract: BACKGROUND
  Several studies have shown that obese persons have lower circulating natriuretic peptide (NP) concentrations. The cause of the relative NP deficiency seen in obese persons is poorly understood, although variation in body composition and metabolic abnormalities has been suggested to play a role. Thus, the aim of this study was to assess whether variation in circulating NP concentrations would be associated with differences in metabolic disturbances rather than with differences in body composition.
  
  
  METHODS
  In 27 normal weight men (body mass index (BMI) = 20.0-24.9kg/m(2)) and 103 obese men (BMI ≥ 30kg/m(2)), we determined body composition (total, android, and gynoid fat mass) by dual energy x-ray absorptiometry scanning, and we measured fasting serum concentrations of midregional proatrial NP (MR-proANP) and insulin, as well as fasting plasma glucose concentrations.
  
  
  RESULTS
  Mean weight ± SD was 74.9±6.7kg in the normal weight men and 106.1±10.8kg in obese men. Applying multiple regressions, adjusting for age and weight status (normal weight vs. obese), serum MR-proANP concentrations were significantly inversely associated with serum insulin concentrations (β = -0.39; P < 0.0001) and plasma glucose concentrations (β = -0.21; P = 0.02) but not with total (β = 0.00), android (β = -0.01), or gynoid (β = 0.03) fat mass percentage (P > 0.76). No significant interaction effects between metabolic measurements or body composition measurements and weight status on MR-proANP concentrations were found (P > 0.08).
  
  
  CONCLUSIONS
  In normal weight and obese men, lower circulating NP concentrations are associated with higher insulin and glucose concentrations and not with the proportion of total fat mass or the distribution of fat mass.
authors.affiliation: Department of Diagnostics, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
authors.forename: Camilla L
authors.initials: CL
authors.lastname: Asferg
authors.forename: Søren J
authors.initials: SJ
authors.lastname: Nielsen
authors.forename: Ulrik B
authors.initials: UB
authors.lastname: Andersen
authors.forename: Allan
authors.initials: A
authors.lastname: Linneberg
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Møller
authors.forename: Paula L
authors.initials: PL
authors.lastname: Hedley
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.forename: Jens P
authors.initials: JP
authors.lastname: Gøtze
authors.forename: Jørgen L
authors.initials: JL
authors.lastname: Jeppesen
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009320:Atrial Natriuretic Factor
keywords: blood pressure; body composition; glucose; hypertension; insulin; natriuretic peptides; obesity.