title: [Inadequate secretion of β-human chorionic gonadotropin in lung cancer].
abstract: BACKGROUND
  The inadequate secretion of β-human chorionic gonadotropin (β-HCG) during non-small cell lung cancer (NSCLC) is rare and quite ignored. The dosage of β-HCG is probably not systematically realized in women who are in age of pregnancy and who need chemotherapy (CT) despite the descriptions of cases of prescription of CT against lung cancer in women who were pregnant. The incidence of NSCLC cancer is increasing and the risk to prescribe a CT in a woman who is pregnant is also increasing.
  
  
  METHODS
  We describe the cases of two women and one man who had an augmentation of the β-HCG plasmatic level before the prescription of CT against lung cancer. In women, the differential diagnostic between inadequate secretion of β-HCG and pregnancy has been a problem.
  
  
  CONCLUSIONS
  The inadequate secretion of β-HCG during NSCLC is probably not so rare. The dosage of this hormone before each infusion of CT should be systematic to avoid the realization of CT during pregnancy. This raises the question of the method for differential diagnostic between pregnancy and inadequate secretion of β-HCG in young women who suffer from NSCLC, especially when a small level of β-HCG is measured.
authors.affiliation: Service de pneumologie, hôpitaux de Brabois, centre hospitalier universitaire de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy cedex, France. Electronic address: benoit.godbert@hp-metz.fr.
authors.forename: B
authors.initials: B
authors.lastname: Godbert
authors.forename: A
authors.initials: A
authors.lastname: Tiotiu
authors.forename: C
authors.initials: C
authors.lastname: Masias
authors.forename: Y
authors.initials: Y
authors.lastname: Martinet
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000378:metabolism; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis* / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human
keywords: Cancer bronchique non à petites cellules; Chemotherapy; Chimiothérapie; Grossesse; Hormone chorionique gonadotrope β; Human chorionic gonadotropin β; Inadequate secretion; Non-small cell lung cancer; Pregnancy; Sécrétion inappropriée