title: [Genetic aspects of Alzheimer's disease (Review)].
abstract: Alzheimer's disease is a degenerative brain disorder, which concerns memory, cognition and behavior pattern. Its etiology is unknown, it is characterized by typical histological lesions: senile plaques and neuro-fibrillary tangles. Alzheimer's disease is a multifactorial pathology, characterized by interactions between genetic and environmental factors. Genetic factors concern first of all the exceptional monogenic forms, characterized by early onset (<60 years), autosomal dominant forms. Mutations of the genes coding for amyloid-ß precursor protein or preselinins 1 and 2 are involved. The much more frequent sporadic forms also have genetic factors, the best studied being the apolipoprotein E4 coding allele and some more recent genotypes which will be mentioned. No causal, only symptomatic treatments are available.
authors.affiliation: Laboratoire de génétique médicale et pathologies moléculaires, faculté de médecine et de pharmacie, 19, rue Tarik Ibnou Ziad, BP 9154, 20000 Casablanca, Maroc. Electronic address: elkadmiri1979@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: El Kadmiri
authors.forename: K
authors.initials: K
authors.lastname: Hamzi
authors.forename: B
authors.initials: B
authors.lastname: El Moutawakil
authors.forename: I
authors.initials: I
authors.lastname: Slassi
authors.forename: S
authors.initials: S
authors.lastname: Nadifi
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D018740:Genetic Heterogeneity; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D053764:Presenilin-1 / Q000737:chemistry / Q000235:genetics
chemical_list: D015415:Biomarkers; C508853:PSEN1 protein, human; D053764:Presenilin-1
keywords: Alzheimer's disease; Amyloid-β protein precursor; Apolipoprotein E4 Allele; Apolipoprotein E4 Allèle; Genetic; Génétique; Maladie d’Alzheimer; Presenilin 1; Presenilin 2; Préséniline 1; Préséniline 2