title: Glycine receptor and myelin oligodendrocyte glycoprotein antibodies in Turkish patients with neuromyelitis optica.
abstract: BACKGROUND
  Seronegative NMO is highly prevalent in non-Western countries implying the presence of as yet unknown antibodies (Ab). We investigated potential novel Ab in aquaporin-4 Ab (AQP-4-Ab) positive and negative NMO patients.
  
  
  METHODS
  Sera of 20 NMO patients were examined for AQP-4, myelin oligodendrocyte glycoprotein (MOG) and glycine receptor (GlyR) Ab by cell-based assays.
  
  
  RESULTS
  AQP-4-Ab was identified in 10 NMO patients, MOG-Ab was detected only in one AQP-4-Ab positive patient and GlyR-Ab was detected in two AQP-4-Ab negative patients. GlyR-Ab positive patients displayed simultaneous optic neuritis and transverse myelitis attacks and relatively low disability, whereas MOG and AQP-4-Ab double positive patient had a significantly increased disability.
  
  
  CONCLUSIONS
  This study showed for the first time the presence of GlyR-Ab in Turkish NMO patients. In contrast with previous reports, MOG Ab does not appear to be a distinctive marker for Turkish AQP-4-Ab negative NMO patients.
authors.affiliation: Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Woodhall
authors.forename: Arzu
authors.initials: A
authors.lastname: Çoban
authors.forename: Patrick
authors.initials: P
authors.lastname: Waters
authors.forename: Esme
authors.initials: E
authors.lastname: Ekizoğlu
authors.forename: Murat
authors.initials: M
authors.lastname: Kürtüncü
authors.forename: Erkingul
authors.initials: E
authors.lastname: Shugaiv
authors.forename: Recai
authors.initials: R
authors.lastname: Türkoğlu
authors.forename: Gulsen
authors.initials: G
authors.lastname: Akman-Demir
authors.forename: Mefkure
authors.initials: M
authors.lastname: Eraksoy
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood*; D051401:Aquaporin 4 / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000276:immunology*; D009471:Neuromyelitis Optica / Q000097:blood* / Q000276:immunology; D018009:Receptors, Glycine / Q000276:immunology*; D014421:Turkey; D055815:Young Adult
chemical_list: D000906:Antibodies; D051401:Aquaporin 4; D063308:Myelin-Oligodendrocyte Glycoprotein; D018009:Receptors, Glycine
keywords: Antibody; Aquaporin-4; Glycine receptor; Myelin oligodendrocyte glycoprotein; Neuromyelitis optica; Sera