title: Identification of protein biomarkers associated with cardiac ischemia by a proteomic approach.
abstract: Angina is chest pain induced by ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries. People that suffer from average to severe cases of angina have an increased percentage of death before the age of 55, usually around 60%. Therefore, prevention of major complications, optimizing diagnosis, prognosis and therapeutics are of primary importance. The main objective of this study was to uncover biomarkers by comparing serum protein profiles of patients suffering from stable or unstable angina and controls. We identified by non-targeted proteomic approach and confirmed by the means of independent techniques, the differential expression of several proteins indicating significantly increased vascular inflammation response, disturbance in the lipid metabolism and in atherogenic plaques stability.
authors.affiliation: GIGA Proteomic Unit, Department of Clinical Chemistry, Clinical Chemistry Laboratory .
authors.forename: M
authors.initials: M
authors.lastname: Fillet
authors.forename: C
authors.initials: C
authors.lastname: Deroyer
authors.forename: G
authors.initials: G
authors.lastname: Cobraiville
authors.forename: C
authors.initials: C
authors.lastname: Le Goff
authors.forename: E
authors.initials: E
authors.lastname: Cavalier
authors.forename: J P
authors.initials: JP
authors.lastname: Chapelle
authors.forename: R
authors.initials: R
authors.lastname: Marée
authors.forename: V
authors.initials: V
authors.lastname: Legrand
authors.forename: L
authors.initials: L
authors.lastname: Pierard
authors.forename: Ph
authors.initials: P
authors.lastname: Kolh
authors.forename: M-P
authors.initials: MP
authors.lastname: Merville
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood* / Q000401:mortality; D000789:Angina, Unstable / Q000097:blood* / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality; D020097:Natriuretic Peptide, Brain / Q000097:blood; D058226:Plaque, Atherosclerotic / Q000097:blood; D040901:Proteomics; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008055:Lipids; D014336:Troponin; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein