title: [A comparative study of the myeloprotective effect of dicarbamine and leucostim in experimental post-radiation bone marrow syndrome].
abstract: We studied the effect of dicarbamine and leucostim on myelopoiesis in experimental post-radiation bone marrow syndrome. Dicarbamine in different modes of administration and doses provided a high level of protection of proliferating hematopoietic precursors in the early period after radiation, which was reflected in a statistically significant decrease in the depth and duration of post-radiation deficit of cells, such as of granulocytes, lymphocytes, megakaryocytes and erythroid cells. The greatest effect of the drug appeared at a dose of 4 mg/kg (prophylactic administration) and a dose of 15 mg/kg (curative double dose). In the bone marrow of experimental animals leucostim prevented development of post-radiation deficit of granulocytes and lymphocytes to a lesser extent, than dicarbamine, and it was effective for erythroid cells and megakaryocytes.
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Moiseeva
authors.forename: L V
authors.initials: LV
authors.lastname: Ionicheva
authors.forename: S A
authors.initials: SA
authors.lastname: Nikishin
authors.forename: O P
authors.initials: OP
authors.lastname: Rodina
authors.forename: O A
authors.initials: OA
authors.lastname: Vodop'ianova
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D002208:Caproates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects / Q000528:radiation effects; D011817:Rabbits; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013577:Syndrome; D013997:Time Factors
chemical_list: D002208:Caproates; D007093:Imidazoles; D011837:Radiation-Protective Agents; D016179:Granulocyte Colony-Stimulating Factor; C539419:pentanedioic acid imidazolyl ethanamide