title: Dupuytren's Contracture Cosegregation with Limb-Girdle Muscle Dystrophy.
abstract: Limb-girdle muscular dystrophies (LGMDs) is a heterogeneous group of muscular dystrophies that mostly affect the pelvic and shoulder girdle muscle groups. We report here a case of neuromuscular disease associated with Dupuytren's contracture, which has never been described before as cosegregating with an autosomal dominant type of inheritance. Dupuytren's contracture is a common disease, especially in Northern Europe. Comorbid conditions associated with Dupuytren's contracture are repetitive trauma to the hands, diabetes, and seizures, but it has never before been associated with neuromuscular disease. We hypothesize that patients may harbor mutations in genes with functions related to neuromuscular disease and Dupuytren's contracture development.
authors.affiliation: Latvian Biomedical Research and Study Centre, Ratsupites Street 1, Riga 1067, Latvia.
authors.forename: Baiba
authors.initials: B
authors.lastname: Lace
authors.forename: Inna
authors.initials: I
authors.lastname: Inashkina
authors.forename: Ieva
authors.initials: I
authors.lastname: Micule
authors.forename: Inta
authors.initials: I
authors.lastname: Vasiljeva
authors.forename: Maruta Solvita
authors.initials: MS
authors.lastname: Naudina
authors.forename: Jurgis
authors.initials: J
authors.lastname: Strautmanis
authors.forename: Janis
authors.initials: J
authors.lastname: Stavusis
authors.forename: Eriks
authors.initials: E
authors.lastname: Jankevics
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