title: What do we learn from repeated population analyses?
abstract: Population analyses are performed on new and existing drugs. They play an important role in quantifying the time course of drug effects and provide a means of understanding the impact of variability between individuals on dosing requirements. For some drugs there have been several population analyses reported in the literature. It is important to understand how repeated population analyses can value add and what authors and readers can consider when reviewing such analyses. The purpose of this review is to explore what is learnt from repeated population analyses and provide an understanding of how the value-added nature of these analyses can be considered.
authors.affiliation: School of Pharmacy, University of Otago, PO Box 56, Dunedin, New Zealand.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Duffull
authors.forename: Daniel F B
authors.initials: DF
authors.lastname: Wright
mesh_terms: D017984:Enoxaparin / Q000493:pharmacokinetics*; D006801:Humans; D008954:Models, Biological
chemical_list: D017984:Enoxaparin
keywords: enoxaparin; population PK
references.citation: Clin Chem. 1997 Jan;43(1):104-8
references.pmid: 8990230
references.citation: Br J Clin Pharmacol. 2007 Oct;64(4):428-38
references.pmid: 17509040
references.citation: Br J Clin Pharmacol. 2005 Mar;59(3):281-90
references.pmid: 15752373
references.citation: Clin Pharmacol Ther. 2008 Sep;84(3):370-7
references.pmid: 18431408
references.citation: Br J Clin Pharmacol. 2005 Oct;60(4):364-73
references.pmid: 16187968
references.citation: J Pharmacokinet Biopharm. 1977 Oct;5(5):445-79
references.pmid: 925881
references.citation: Br J Clin Pharmacol. 2003 Oct;56(4):407-14
references.pmid: 12968985
references.citation: Stat Med. 2002 Sep 30;21(18):2623-39
references.pmid: 12228881
references.citation: Br J Clin Pharmacol. 2009 Nov;68(5):700-11
references.pmid: 19916994
references.citation: Br J Clin Pharmacol. 2006 Aug;62(2):165-76
references.pmid: 16842391
references.citation: Br J Clin Pharmacol. 2003 Jul;56(1):96-103
references.pmid: 12848781
references.citation: Br J Clin Pharmacol. 2011 Jun;71(6):807-14
references.pmid: 21204908
references.citation: Ther Drug Monit. 2004 Jun;26(3):305-10
references.pmid: 15167633
references.citation: Clin Pharmacol Ther. 2005 Jun;77(6):542-52
references.pmid: 15961985
references.citation: Br J Clin Pharmacol. 1993 Jul;36(1):51-6
references.pmid: 8396956
references.citation: Biol Pharm Bull. 2006 Feb;29(2):275-80
references.pmid: 16462031
references.citation: Br J Clin Pharmacol. 2011 Jun;71(6):815-23
references.pmid: 21272054
references.citation: J Clin Pharm Ther. 2005 Jun;30(3):207-13
references.pmid: 15896237
references.citation: Br J Clin Pharmacol. 1996 Sep;42(3):283-90
references.pmid: 8877017