title: Harvestman phenols and benzoquinones: characterisation and biosynthetic pathway.
abstract: Benzoquinones are usually present in arthropod defence exudates. Here, we describe the chemical profiles of 12 harvestman species belonging to the neotropical family Gonyleptidae. Nine of the studied species produced benzoquinones, while three produced alkyl phenols. Two benzoquinones and one phenol exhibited biological activity against bacteria and fungi. We also studied the biosynthesis of 2-ethyl-1,4-benzoquinone by feeding Magnispina neptunus individuals with ¹³C-labelled precursors; the benzoquinones were biosynthesised through a polyketide pathway using acetate and propionate building blocks.
authors.affiliation: Instituto de Química, Universidade Estadual de Campinas, C.P. 6154, 13083-970 Campinas, SP, Brasil.
authors.forename: Daniele F O
authors.initials: DF
authors.lastname: Rocha
authors.forename: Felipe C
authors.initials: FC
authors.lastname: Wouters
authors.forename: Dávila S
authors.initials: DS
authors.lastname: Zampieri
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Brocksom
authors.forename: Glauco
authors.initials: G
authors.lastname: Machado
authors.forename: Anita J
authors.initials: AJ
authors.lastname: Marsaioli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001097:Arachnida / Q000737:chemistry / Q000378:metabolism*; D001407:Bacillus / Q000187:drug effects; D016227:Benzoquinones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D053898:Biosynthetic Pathways; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016227:Benzoquinones; D010636:Phenols
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