title: Beta-tricalcium phosphate shows superior absorption rate and osteoconductivity compared to hydroxyapatite in open-wedge high tibial osteotomy.
abstract: OBJECTIVE
  The purpose of this study was to clinically and radiologically compare the utility, osteoconductivity, and absorbability of hydroxyapatite (HAp) and beta-tricalcium phosphate (TCP) spacers in medial open-wedge high tibial osteotomy (HTO).
  
  
  METHODS
  Thirty-eight patients underwent medial open-wedge HTO with a locking plate. In the first 19 knees, a HAp spacer was implanted in the opening space (HAp group). In the remaining 19 knees, a TCP spacer was implanted in the same manner (TCP group). All patients underwent clinical and radiological examinations before surgery and at 18 months after surgery.
  
  
  RESULTS
  Concerning the background factors, there were no statistical differences between the two groups. Post-operatively, the knee score significantly improved in each group. Concerning the post-operative knee alignment and clinical outcome, there was no statistical difference in each parameter between the two groups. Regarding the osteoconductivity, the modified van Hemert's score of the TCP group was significantly higher (p = 0.0009) than that of the HAp group in the most medial osteotomy zone. The absorption rate was significantly greater in the TCP group than in the HAp group (p = 0.00039).
  
  
  CONCLUSIONS
  The present study demonstrated that a TCP spacer was significantly superior to a HAp spacer concerning osteoconductivity and absorbability at 18 months after medial open-wedge HTO.
  
  
  METHODS
  Retrospective comparative study, Level III.
authors.affiliation: Department of Sports Medicine and Joint Surgery, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Onodera
authors.forename: Eiji
authors.initials: E
authors.lastname: Kondo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Omizu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ueda
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yagi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D001860:Bone Plates; D002130:Calcium Phosphates; D017886:Durapatite; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D010027:Osteotomy; D012189:Retrospective Studies; D013977:Tibia / Q000601:surgery*
chemical_list: D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):197-205
references.pmid: 22773067
references.citation: J Biomed Mater Res B Appl Biomater. 2012 Nov;100(8):2044-52
references.pmid: 22865716
references.citation: Biomaterials. 2007 Jun;28(16):2612-21
references.pmid: 17316789
references.citation: Knee Surg Sports Traumatol Arthrosc. 2003 May;11(3):132-8
references.pmid: 12774149
references.citation: Ann Rheum Dis. 1957 Dec;16(4):494-502
references.pmid: 13498604
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):82-9
references.pmid: 21983702
references.citation: J Biomed Mater Res B Appl Biomater. 2005 Jan 15;72(1):94-101
references.pmid: 15376187
references.citation: Biomaterials. 2010 Mar;31(7):1465-85
references.pmid: 19969343
references.citation: Clin Orthop Relat Res. 2000 Feb;(371):10-27
references.pmid: 10693546
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):170-80
references.pmid: 22744433
references.citation: J Orthop Sci. 2008 Nov;13(6):550-5
references.pmid: 19089543
references.citation: Knee. 2004 Dec;11(6):451-6
references.pmid: 15581763
references.citation: J Biomed Mater Res. 1998 Dec 5;42(3):357-67
references.pmid: 9788497
references.citation: Orthop Traumatol Surg Res. 2010 Oct;96(6):637-45
references.pmid: 20832381
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):3-22
references.pmid: 23052110
references.citation: J Bone Joint Surg Am. 2002 Mar;84(3):454-64
references.pmid: 11886919
references.citation: Biomaterials. 2008 Jan;29(3):266-71
references.pmid: 18029011
references.citation: Orthop Clin North Am. 2005 Oct;36(4):497-504
references.pmid: 16164954
references.citation: Clin Orthop Relat Res. 1992 Sep;(282):186-95
references.pmid: 1516311
references.citation: J Bone Joint Surg Am. 2003 Jan;85(1):78-85
references.pmid: 12533576
references.citation: J Bone Joint Surg Am. 1974 Jan;56(1):155-60
references.pmid: 4812159
references.citation: Injury. 2003 Nov;34 Suppl 2:B55-62
references.pmid: 14580986
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13614-9
references.pmid: 20643969
references.citation: Radiology. 1971 Oct;101(1):101-4
references.pmid: 5111961
references.citation: J Bone Joint Surg Br. 2006 Oct;88(10):1336-40
references.pmid: 17012424
references.citation: J Knee Surg. 2009 Jul;22(3):218-25
references.pmid: 19634725
references.citation: Injury. 2013 Jan;44 Suppl 1:S28-33
references.pmid: 23351866
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):64-73
references.pmid: 21409470
references.citation: Injury. 2011 Sep;42 Suppl 2:S22-5
references.pmid: 21714966
references.citation: J Biomed Mater Res A. 2014 May;102(5):1399-407
references.pmid: 23733500
references.citation: J Oral Maxillofac Surg. 2003 Sep;61(9):1045-53
references.pmid: 12966480
references.citation: Arch Orthop Trauma Surg. 2009 Jun;129(6):747-52
references.pmid: 19015864
references.citation: J Biomed Mater Res A. 2003 Dec 1;67(3):713-8
references.pmid: 14613217
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):146-51
references.pmid: 22622776
references.citation: J Biomed Mater Res A. 2004 Sep 15;70(4):542-9
references.pmid: 15307158
references.citation: J Biomed Mater Res B Appl Biomater. 2009 Nov;91(2):788-98
references.pmid: 19572298
references.citation: Biomaterials. 1990 Sep;11(7):509-12
references.pmid: 2242400
references.citation: Orthop Traumatol Surg Res. 2011 Nov;97(7):705-11
references.pmid: 22001198
references.citation: Eur J Pediatr Surg. 1992 Jun;2(3):180-2
references.pmid: 1498113
references.citation: Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):23-31
references.pmid: 23052112
references.citation: Acta Biomater. 2013 Feb;9(2):4956-63
references.pmid: 23036944
references.citation: J Mater Sci Mater Med. 2008 Apr;19(4):1823-9
references.pmid: 18157508
references.citation: Arthroscopy. 2009 Jan;25(1):46-53
references.pmid: 19111218