title: Molecular mechanisms of incretin hormone secretion.
abstract: Incretin peptides (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) are secreted from enteroendocrine cells in the intestinal epithelium, and help to coordinate metabolic responses to food ingestion. A number of molecular mechanisms have recently been defined that underlie carbohydrate, lipid and protein sensing in gut endocrine cells. Knockout mice lacking sodium glucose tranporter-1 (SGLT-1) or the short chain fatty acid sensing receptor FFAR2 (GPR43), for example, have highlighted the importance of these molecules in incretin secretion. This review outlines our current understanding of sensory pathways in incretin secreting cells and highlights the therapeutic potential of targeting them for the development of novel therapies for obesity and diabetes.
authors.affiliation: Cambridge Institute for Medical Research, Wellcome Trust, MRC Building, Addenbrooke's Hospital, Box 139, Hills Road, Cambridge CB2 0XY, UK.
authors.forename: Marina
authors.initials: M
authors.lastname: Ezcurra
authors.forename: Frank
authors.initials: F
authors.lastname: Reimann
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Gribble
authors.forename: Edward
authors.initials: E
authors.lastname: Emery
mesh_terms: D000818:Animals; D019858:Enteroendocrine Cells / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*
chemical_list: D005768:Gastrointestinal Hormones; D054795:Incretins
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