title: Development of microencapsulation delivery system for long-term preservation of probiotics as biotherapeutics agent.
abstract: The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile concentration commonly encountered in the gastrointestinal tract of humans. Providing probiotic living cells with a physical barrier against adverse environmental conditions is therefore an approach currently receiving considerable interest. Probiotic encapsulation technology has the potential to protect microorganisms and to deliver them into the gut. However, there are still many challenges to overcome with respect to the microencapsulation process and the conditions prevailing in the gut. This review focuses mainly on the methodological approach of probiotic encapsulation including biomaterials selection and choice of appropriate technology in detailed manner.
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Sayli-Silvassa Road, Sayli, Silvassa, Dora and Nagar Haveli 396230, India ; Hemchandracharya North Gujarat University, Patan, Gujarat 384265, India.
authors.forename: Himanshu K
authors.initials: HK
authors.lastname: Solanki
authors.forename: Dipak D
authors.initials: DD
authors.lastname: Pawar
authors.forename: Dushyant A
authors.initials: DA
authors.lastname: Shah
authors.forename: Vipul D
authors.initials: VD
authors.lastname: Prajapati
authors.forename: Girish K
authors.initials: GK
authors.lastname: Jani
authors.forename: Akil M
authors.initials: AM
authors.lastname: Mulla
authors.forename: Prachi M
authors.initials: PM
authors.lastname: Thakar
mesh_terms: D004339:Drug Compounding; D016503:Drug Delivery Systems; D041981:Gastrointestinal Tract / Q000187:drug effects; D006801:Humans; D007778:Lactobacillus / Q000254:growth & development*; D019936:Probiotics / Q000008:administration & dosage*
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