title: A practical access to highly enantiomerically pure flavanones by catalytic asymmetric transfer hydrogenation.
abstract: A surprisingly selective, non-enzymatic kinetic resolution of readily available, racemic β-chiral ketones enabled the title process, which was applied to a rapid synthesis of several bioactive flavanones in virtually enantiopure form (see scheme; MOM=methoxymethyl, Ts=p-toluenesulfonyl).
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden (Germany) http://www.chm.tu-dresden.de/oc1/
authors.forename: Marie-Kristin
authors.initials: MK
authors.lastname: Lemke
authors.forename: Pia
authors.initials: P
authors.lastname: Schwab
authors.forename: Petra
authors.initials: P
authors.lastname: Fischer
authors.forename: Sandra
authors.initials: S
authors.lastname: Tischer
authors.forename: Morris
authors.initials: M
authors.lastname: Witt
authors.forename: Laurence
authors.initials: L
authors.lastname: Noehringer
authors.forename: Victor
authors.initials: V
authors.lastname: Rogachev
authors.forename: Anne
authors.initials: A
authors.lastname: Jäger
authors.forename: Olga
authors.initials: O
authors.lastname: Kataeva
authors.forename: Roland
authors.initials: R
authors.lastname: Fröhlich
authors.forename: Peter
authors.initials: P
authors.lastname: Metz
mesh_terms: D001688:Biological Products; D002384:Catalysis; D044950:Flavanones / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D044950:Flavanones
keywords: asymmetric catalysis; flavonoids; glabrol; kinetic resolution; natural products