title: Cardiovascular changes during chronic hypertensive states.
abstract: It is well established that elevated blood pressure constitutes a major risk factor for coronary heart disease, arrythmias, heart failure, cerebrovascular disease, peripheral artery disease and renal failure. Blood pressure level and the duration of arterial hypertension (HTN) impact target organ damage. Many studies in adults have demonstrated the role of antihypertensive therapy in preventing cardiovascular (CV) events. The so-called hard end-points, such as death, myocardial infarction (MI) or stroke, are rarely seen in children, but intermediate target organ damage, including left ventricular hypertrophy, increased intima-media thickness and microalbuminuria, is already detectable during childhood. The goal of antihypertensive treatment is to reduce the global risk of CV events. In the adult population stratification of CV risk is based on blood pressure level, risk factors, subclinical target organ damage and established CV and kidney disease. Increased CV risk begins early in the course of kidney disease, and CV diseases are the most frequent cause of morbidity and mortality in patients with chronic kidney disease (CKD). Children with CKD are especially prone to the long-term effects of CV risk factors, which result in high morbidity and mortality in young adults. To improve the outcome, pediatric and adult CKD patients require nephro- and cardioprotection.
authors.affiliation: Dialysis Unit, Jagiellonian University Medical College, 265 Wielicka Str., 30-663, Krakow, Poland, dadrozdz@cm-uj.krakow.pl.
authors.forename: Dorota
authors.initials: D
authors.lastname: Drozdz
authors.forename: Kalina
authors.initials: K
authors.lastname: Kawecka-Jaszcz
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D002648:Child; D002908:Chronic Disease; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents
references.citation: JAMA. 1996 May 22-29;275(20):1557-62
references.pmid: 8622246
references.citation: J Pediatr. 2003 Dec;143(6):720-4
references.pmid: 14657815
references.citation: Pediatr Nephrol. 2008 Dec;23(12):2233-9
references.pmid: 18597123
references.citation: Clin J Am Soc Nephrol. 2011 Aug;6(8):1934-43
references.pmid: 21737857
references.citation: Eur Heart J. 2007 Oct;28(20):2539-50
references.pmid: 17428822
references.citation: Hypertension. 2005 Apr;45(4):493-8
references.pmid: 15767467
references.citation: Eur Heart J. 2012 Jul;33(13):1635-701
references.pmid: 22555213
references.citation: Am J Kidney Dis. 1998 Nov;32(5 Suppl 3):S112-9
references.pmid: 9820470
references.citation: Am J Cardiol. 1992 Oct 1;70(9):851-8
references.pmid: 1529936
references.citation: Emerg Med Int. 2011;2011:734506
references.pmid: 22254140
references.citation: J Am Coll Cardiol. 2009 Jan 20;53(3):284-91
references.pmid: 19147047
references.citation: J Clin Hypertens (Greenwich). 2012 Jun;14(6):353-9
references.pmid: 22672088
references.citation: Nephrol Dial Transplant. 2009 Jun;24(6):1987-91
references.pmid: 19225014
references.citation: Pediatrics. 2007 Feb;119(2):237-46
references.pmid: 17272612
references.citation: Cardiovasc Ultrasound. 2012 Mar 19;10:10
references.pmid: 22429658
references.citation: J Hypertens. 2009 Sep;27(9):1719-42
references.pmid: 19625970
references.citation: Heart. 2005 Apr;91(4):553-8
references.pmid: 15772232
references.citation: Am Heart J. 1999 Sep;138(3 Pt 2):220-4
references.pmid: 10467216
references.citation: Kidney Int. 2002 Aug;62(2):648-53
references.pmid: 12110030
references.citation: Am J Hypertens. 2010 Jan;23(1):24-9
references.pmid: 19851297
references.citation: Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
references.pmid: 15286277
references.citation: Ochsner J. 2009 Winter;9(4):181-90
references.pmid: 21603442
references.citation: Nephrol Dial Transplant. 2009 Nov;24(11):3525-32
references.pmid: 19541662
references.citation: J Clin Hypertens (Greenwich). 2011 May;13(5):332-42
references.pmid: 21545394
references.citation: Arch Intern Med. 2012 Jan 9;172(1):41-7
references.pmid: 22232147
references.citation: Atherosclerosis. 2009 Mar;203(1):172-7
references.pmid: 18603254
references.citation: Nat Rev Neurol. 2011 Apr;7(4):199-208
references.pmid: 21386815
references.citation: Clin J Am Soc Nephrol. 2011 Aug;6(8):1926-33
references.pmid: 21737855
references.citation: J Am Coll Cardiol. 2001 Dec;38(7):1829-35
references.pmid: 11738281
references.citation: J Am Coll Cardiol. 2010 Jan 12;55(2):91-6
references.pmid: 20117376
references.citation: Pediatrics. 2011 Dec;128 Suppl 5:S213-56
references.pmid: 22084329
references.citation: J Hypertens. 2013 Jul;31(7):1281-357
references.pmid: 23817082
references.citation: JAMA. 2004 Nov 17;292(19):2350-6
references.pmid: 15547162
references.citation: J Am Soc Nephrol. 2007 Feb;18(2):593-8
references.pmid: 17215443
references.citation: Pediatrics. 2010 Dec;126(6):e1425-9
references.pmid: 21059718
references.citation: J Hypertens. 2008 Apr;26(4):721-8
references.pmid: 18327082
references.citation: Hypertension. 2007 Nov;50(5):851-3
references.pmid: 17893369
references.citation: Circulation. 2000 Sep 19;102(12):1388-93
references.pmid: 10993857
references.citation: J Am Soc Nephrol. 2010 Jan;21(1):137-44
references.pmid: 19917781
references.citation: N Engl J Med. 2002 Sep 12;347(11):797-805
references.pmid: 12226150
references.citation: Hypertension. 2012 Oct;60(4):1047-54
references.pmid: 22892814
references.citation: Hypertension. 2009 Nov;54(5):1084-91
references.pmid: 19770405
references.citation: Circulation. 2008 May 27;117(21):2769-75
references.pmid: 18490525
references.citation: Lancet. 2002 Dec 14;360(9349):1903-13
references.pmid: 12493255
references.citation: J Am Soc Nephrol. 2004 Aug;15(8):1983-92
references.pmid: 15284284
references.citation: Pediatr Nephrol. 2011 Jun;26(6):853-65
references.pmid: 21080003
references.citation: Can J Cardiol. 2011 May-Jun;27(3):302-10
references.pmid: 21601770
references.citation: J Am Coll Cardiol. 2002 Jun 19;39(12):2005-11
references.pmid: 12084601
references.citation: Hypertension. 2012 Aug;60(2):296-302
references.pmid: 22710648
references.citation: Pol Merkur Lekarski. 2008;24 Suppl 4:98-100
references.pmid: 18924516
references.citation: Pediatr Nephrol. 2010 Dec;25(12):2489-99
references.pmid: 20730452
references.citation: Kidney Int. 2004 Apr;65(4):1461-6
references.pmid: 15086489
references.citation: N Engl J Med. 2009 Oct 22;361(17):1639-50
references.pmid: 19846849
references.citation: J Diabetes Complications. 2012 Nov-Dec;26(6):540-5
references.pmid: 22770940
references.citation: Lancet. 2002 Nov 2;360(9343):1347-60
references.pmid: 12423980
references.citation: J Am Coll Cardiol. 1992 Jun;19(7):1550-8
references.pmid: 1534335
references.citation: Ren Fail. 2010 Jan;32(1):1-9
references.pmid: 20113258
references.citation: J Hypertens. 2008 Jul;26(7):1477-86
references.pmid: 18551026
references.citation: Circulation. 2004 Sep 14;110(11):1456-62
references.pmid: 15326072
references.citation: Eur Heart J. 2010 Apr;31(7):883-91
references.pmid: 20034972
references.citation: J Am Soc Echocardiogr. 2009 Jun;22(6):709-14
references.pmid: 19423289
references.citation: J Am Soc Nephrol. 2010 Jan;21(1):103-12
references.pmid: 19959717
references.citation: Nephrol Dial Transplant. 2010 Jul;25(7):2296-303
references.pmid: 20139065
references.citation: Lancet. 2001 Sep 29;358(9287):1033-41
references.pmid: 11589932
references.citation: Clin J Am Soc Nephrol. 2011 Dec;6(12):2759-65
references.pmid: 21980183
references.citation: Kidney Int Suppl (2011). 2011 Jun;1(1):13-16
references.pmid: 25018897
references.citation: Lancet. 2008 May 3;371(9623):1513-8
references.pmid: 18456100
references.citation: Kidney Int. 1996 Sep;50(3):998-1006
references.pmid: 8872976
references.citation: Clin J Am Soc Nephrol. 2013 Feb;8(2):203-10
references.pmid: 23124781
references.citation: Pharmacol Rep. 2005;57 Suppl:86-96
references.pmid: 16415489