title: Phenylethynylcobalamin: a light-stable and thermolysis-resistant organometallic vitamin B(12) derivative prepared by radical synthesis.
abstract: Don't take this antivitamin! 2-Phenylethynylcobalamin was prepared in a newly developed radical reaction using cob(II)alamin and 1-iodo-2-phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light-stable and heat-resistant organometallic cobalamin. It is bound well by two important proteins of the human B12 transport system and has properties that are as expected for a new type of an "antivitamin B12 ".
authors.affiliation: Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck (Austria).
authors.forename: Markus
authors.initials: M
authors.lastname: Ruetz
authors.forename: Robert
authors.initials: R
authors.lastname: Salchner
authors.forename: Klaus
authors.initials: K
authors.lastname: Wurst
authors.forename: Sergey
authors.initials: S
authors.lastname: Fedosov
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kräutler
mesh_terms: D000480:Alkynes; D002384:Catalysis; D006801:Humans; D010777:Photochemistry; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000480:Alkynes; D014805:Vitamin B 12
keywords: alkynes; bioorganometallic chemistry; photochemistry; thermochemistry; vitamin B12