title: Predictors of coupling between structural and functional cortical networks in normal aging.
abstract: Understanding how the mammalian neocortex creates cognition largely depends on knowledge about large-scale cortical organization. Accumulated evidence has illuminated cortical substrates of cognition across the lifespan, but how topological properties of cortical networks support structure-function relationships in normal aging remains an open question. Here we investigate the role of connections (i.e., short/long and direct/indirect) and node properties (i.e., centrality and modularity) in predicting functional-structural connectivity coupling in healthy elderly subjects. Connectivity networks were derived from correlations of cortical thickness and cortical glucose consumption in resting state. Local-direct connections (i.e., nodes separated by less than 30 mm) and node modularity (i.e., a set of nodes highly interconnected within a topological community and sparsely interconnected with nodes from other modules) in the functional network were identified as the main determinants of coupling between cortical networks, suggesting that the structural network in aging is mainly constrained by functional topological properties involved in the segregation of information, likely due to aging-related deficits in functional integration. This hypothesis is supported by an enhanced connectivity between cortical regions of different resting-state networks involved in sensorimotor and memory functions in detrimental to associations between fronto-parietal regions supporting executive processes. Taken collectively, these findings open new avenues to identify aging-related failures in the anatomo-functional organization of the neocortical mantle, and might contribute to early detection of prevalent neurodegenerative conditions occurring in the late life.
authors.affiliation: Laboratory of Functional Neuroscience, Spanish Network of Excellence for Research on Neurodegenerative Diseases (CIBERNED), University Pablo de Olavide, Seville, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Romero-Garcia
authors.forename: Mercedes
authors.initials: M
authors.lastname: Atienza
authors.forename: Jose L
authors.initials: JL
authors.lastname: Cantero
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology* / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology; D009929:Organ Size; D049268:Positron-Emission Tomography; D012146:Rest / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: FDG-PET; aging; cortical thickness; functional connectivity; functional-structural coupling; large-scale cortical networks; structural connectivity
references.citation: Brain. 2011 Oct;134(Pt 10):2912-28
references.pmid: 21975588
references.citation: Brain Topogr. 2011 Oct;24(3-4):279-91
references.pmid: 21842406
references.citation: Brain Connect. 2011;1(1):37-47
references.pmid: 22432953
references.citation: Magn Reson Imaging. 2008 Sep;26(7):914-20
references.pmid: 18479871
references.citation: Cereb Cortex. 2005 Sep;15(9):1332-42
references.pmid: 15635061
references.citation: Cereb Cortex. 2005 Nov;15(11):1676-89
references.pmid: 15703252
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10240-5
references.pmid: 17548818
references.citation: Hum Brain Mapp. 2012 Mar;33(3):552-68
references.pmid: 21391279
references.citation: Stat Appl Genet Mol Biol. 2007;6:Article9
references.pmid: 17402924
references.citation: Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
references.pmid: 19188601
references.citation: Hum Brain Mapp. 2009 Oct;30(10):3127-41
references.pmid: 19235882
references.citation: Cereb Cortex. 2009 Mar;19(3):554-62
references.pmid: 18552356
references.citation: Psychophysiology. 2004 Jan;41(1):142-51
references.pmid: 14693009
references.citation: Nature. 1998 Jun 4;393(6684):440-2
references.pmid: 9623998
references.citation: Brain. 2009 Dec;132(Pt 12):3366-79
references.pmid: 19439423
references.citation: Biol Psychiatry. 2010 Jul 1;68(1):61-9
references.pmid: 20497901
references.citation: PLoS One. 2010 Oct 28;5(10):e13701
references.pmid: 21060892
references.citation: Neuroimage. 2012 Sep;62(3):1705-16
references.pmid: 22683383
references.citation: Cereb Cortex. 2011 Sep;21(9):2147-57
references.pmid: 21330467
references.citation: Science. 2002 May 3;296(5569):910-3
references.pmid: 11988575
references.citation: Neuroimage. 2002 May;16(1):241-50
references.pmid: 11969331
references.citation: Cereb Cortex. 2009 Jan;19(1):72-8
references.pmid: 18403396
references.citation: Cereb Cortex. 2004 Aug;14(8):892-902
references.pmid: 15084494
references.citation: Neuroimage. 2011 Feb 1;54(3):1862-71
references.pmid: 20650319
references.citation: J Nucl Med. 2004 Sep;45(9):1471-9
references.pmid: 15347713
references.citation: Neuroimage. 2010 May 1;50(4):1497-510
references.pmid: 20083210
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19067-72
references.pmid: 20956328
references.citation: Neurology. 2001 Aug 28;57(4):632-8
references.pmid: 11524471
references.citation: J Neurosci. 2008 Sep 10;28(37):9239-48
references.pmid: 18784304
references.citation: Cereb Cortex. 2008 Oct;18(10):2374-81
references.pmid: 18267952
references.citation: Int J Psychophysiol. 2010 Sep;77(3):186-94
references.pmid: 20598763
references.citation: Neuroimage. 2012 Jan 16;59(2):1239-48
references.pmid: 21884805
references.citation: Neuroimage. 2010 Aug 1;52(1):290-301
references.pmid: 20385244
references.citation: Neuroimage. 2010 Apr 15;50(3):862-72
references.pmid: 20093190
references.citation: Neuroimage. 2012 Feb 15;59(4):3522-32
references.pmid: 22094643
references.citation: Neuroimage. 2006 Jul 1;31(3):968-80
references.pmid: 16530430
references.citation: Neuroimage. 2006 Jul 1;31(3):993-1003
references.pmid: 16624590
references.citation: Cereb Cortex. 2009 Sep;19(9):2001-12
references.pmid: 19150922
references.citation: IEEE Trans Med Imaging. 2007 Nov;26(11):1464-71
references.pmid: 18041262
references.citation: Ann N Y Acad Sci. 2007 Feb;1097:67-83
references.pmid: 17413013
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2181-6
references.pmid: 18238903
references.citation: Neuroimage. 2009 Feb 1;44(3):715-23
references.pmid: 19027073
references.citation: Neuroimage. 2011 May 1;56(1):235-45
references.pmid: 21238595
references.citation: Neuroimage. 2008 Feb 1;39(3):1396-407
references.pmid: 17997112
references.citation: Hum Brain Mapp. 2012 Jun;33(6):1393-406
references.pmid: 21557387
references.citation: PLoS Comput Biol. 2007 Feb 2;3(2):e17
references.pmid: 17274684
references.citation: Stat Appl Genet Mol Biol. 2005;4:Article32
references.pmid: 16646851
references.citation: Cereb Cortex. 2007 Oct;17(10):2407-19
references.pmid: 17204824
references.citation: Neuroimage. 2010 Nov 1;53(2):373-82
references.pmid: 20493267
references.citation: J Comp Neurol. 1989 Sep 22;287(4):422-45
references.pmid: 2477406
references.citation: Cereb Cortex. 2012 Jul;22(7):1530-41
references.pmid: 21878484
references.citation: J Neurosci. 2011 Apr 13;31(15):5816-28
references.pmid: 21490223
references.citation: Hum Brain Mapp. 2009 Jul;30(7):2220-31
references.pmid: 18830955
references.citation: J Am Stat Assoc. 2009 Jun 1;104(486):735-746
references.pmid: 19881892
references.citation: J Neurosci. 2008 Apr 30;28(18):4756-66
references.pmid: 18448652
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14504-9
references.pmid: 14608034
references.citation: Neuroimage. 2008 Nov 15;43(3):447-57
references.pmid: 18692144
references.citation: PLoS Comput Biol. 2010 Jun 10;6(6):e1000808
references.pmid: 20548945
references.citation: Aging Dis. 2012 Apr;3(2):181-93
references.pmid: 22724079
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May;71(5 Pt 2):057101
references.pmid: 16089694
references.citation: J Cogn Neurosci. 2006 Feb;18(2):227-41
references.pmid: 16494683
references.citation: J Neurosci. 2008 Oct 22;28(43):10844-51
references.pmid: 18945892