title: Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss.
abstract: OBJECTIVE
  We aimed to determine: (1) whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss, compared with healthy controls; and (2) whether mean platelet volume level was related to hearing loss severity.
  
  
  METHODS
  The study included 31 patients with sudden sensorineural hearing loss and 31 age- and sex-matched, healthy controls. Peripheral venous blood samples were taken from subjects and mean platelet volume and levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride were measured.
  
  
  RESULTS
  Mean platelet volume was significantly greater in the sudden sensorineural hearing loss group compared with the control group. However, there was no significant correlation between mean platelet volume level and hearing loss severity.
  
  
  CONCLUSIONS
  Mean platelet volume, a determinant of platelet activation, is elevated in patients with sudden sensorineural hearing loss. To our knowledge, this is the first report investigating mean platelet volume levels in such patients. Our findings indirectly support the hypothesis of vascular impairment as a pathogenetic factor in sudden sensorineural hearing loss.
authors.affiliation: Department of ENT, Kayseri Training and Research Hospital, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Sagit
authors.forename: M
authors.initials: M
authors.lastname: Kavugudurmaz
authors.forename: S
authors.initials: S
authors.lastname: Guler
authors.forename: M A
authors.initials: MA
authors.lastname: Somdas
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood / Q000209:etiology* / Q000473:pathology; D003639:Hearing Loss, Sudden / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation; D012720:Severity of Illness Index; D055815:Young Adult