title: Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer.
abstract: BACKGROUND
  Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.
  
  
  METHODS
  Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases.
  
  
  RESULTS
  Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(-2) (RR=0.56; 95% CI: 0.36-0.89).
  
  
  CONCLUSIONS
  Coffee may protect against Type I EC in obese postmenopausal women.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Rochester, MN 55901, USA.
authors.forename: S
authors.initials: S
authors.lastname: Uccella
authors.forename: A
authors.initials: A
authors.lastname: Mariani
authors.forename: A H
authors.initials: AH
authors.lastname: Wang
authors.forename: R A
authors.initials: RA
authors.lastname: Vierkant
authors.forename: W A
authors.initials: WA
authors.lastname: Cliby
authors.forename: K
authors.initials: K
authors.lastname: Robien
authors.forename: K E
authors.initials: KE
authors.lastname: Anderson
authors.forename: J R
authors.initials: JR
authors.lastname: Cerhan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002110:Caffeine; D003069:Coffee; D004435:Eating; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D005518:Food Preferences; D006801:Humans; D008875:Middle Aged; D009765:Obesity; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014970:Xanthines / Q000008:administration & dosage*
chemical_list: D003069:Coffee; D014970:Xanthines; C008514:methylxanthine; D002110:Caffeine
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