title: Endothelial progenitor cells--potential new avenues to improve neoangiogenesis and reendothelialization.
abstract: The term endothelial progenitor cell (EPC) was established more than 10 years ago and is used to refer to a group of circulating cells that display endothelial lineage qualities and are able to home to areas of ischemia or vascular injury and to facilitate the repair of damaged blood vessels or develop new vessels as needed. This chapter reviews the current lineage relationships among all the cells called EPC and will clear the terminology used in EPC research. Furthermore, an overview of the clinical and in vitro research, as well as cytokine and drug interactions and potential EPC applications, is given.
authors.affiliation: Department of Plastic Surgery, academisch ziekenhuis Maastricht, MUMC+, Maastricht, The Netherlands. Electronic address: piatkowski.de.grzymala@gmail.com.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Piatkowski
authors.forename: Gerrit
authors.initials: G
authors.lastname: Grieb
authors.forename: David
authors.initials: D
authors.lastname: Simons
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bernhagen
authors.forename: Rene R
authors.initials: RR
authors.lastname: van der Hulst
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D023822:Tissue Engineering
chemical_list: D004364:Pharmaceutical Preparations
keywords: Cytokines; Drug interactions; Endothelial cells; Hematopoietic cells; Neovascularization; Regeneration