title: Prevalence of the metabolic syndrome in children with psoriatic disease.
abstract: Adults with psoriasis have a greater risk of developing metabolic syndrome (MetS) and cardiovascular disease (CVD), but few studies have investigated the prevalence of MetS and other risk factors for CVD in children with psoriasis. In an assessor-blinded study, 20 children ages 9-17 years with a current or previously documented history of psoriasis involving 5% or more of their body surface area or psoriatic arthritis were compared with a cohort of age- and sex-matched controls with benign nevi, warts, or acne. MetS, our primary endpoint, was defined by the presence of abnormal values in at least three of the following measures: triglycerides, high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), waist circumference, and blood pressure. Secondary endpoints included high-sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Thirty percent (6/20) of children with psoriasis met the criteria for MetS, compared with 5% (1/20) of the control group (p < 0.05). Subjects with psoriasis had higher mean FBG (91.1 mg/dL) than the control group (82.9 mg/dL) (p = 0.01). There were no statistically significant differences in the other four components of MetS, BMI, BMI percentile, hs-CRP, TC, or LDL-C. The results of this trial demonstrate that children with psoriasis have higher rates of MetS than age- and sex-matched controls. It may therefore be important to evaluate children with psoriasis for components of MetS to prevent future CVD morbidity and mortality.
authors.affiliation: Tufts University, School of Medicine, Boston, Massachusetts.
authors.forename: Ari M
authors.initials: AM
authors.lastname: Goldminz
authors.forename: Catherine D
authors.initials: CD
authors.lastname: Buzney
authors.forename: Noori
authors.initials: N
authors.lastname: Kim
authors.forename: Shiu-Chung
authors.initials: SC
authors.lastname: Au
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Levine
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Wang
authors.forename: Eva M
authors.initials: EM
authors.lastname: Volf
authors.forename: Shimrat S
authors.initials: SS
authors.lastname: Yaniv
authors.forename: Todd A
authors.initials: TA
authors.lastname: Kerensky
authors.forename: Manasa
authors.initials: M
authors.lastname: Bhandarkar
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Dumont
authors.forename: Paul F
authors.initials: PF
authors.lastname: Lizzul
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Loo
authors.forename: John W
authors.initials: JW
authors.lastname: Kulig
authors.forename: Mary E
authors.initials: ME
authors.lastname: Brown
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Lopez-Benitez
authors.forename: Laurie C
authors.initials: LC
authors.lastname: Miller
authors.forename: Alice B
authors.initials: AB
authors.lastname: Gottlieb
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D009506:Nevus / Q000453:epidemiology*; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology* / Q000378:metabolism; D012307:Risk Factors; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology*; D014280:Triglycerides / Q000097:blood; D014860:Warts / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides