title: Spiro[4,4]-1,6-nonadiene-based diphosphine oxides in lewis base catalyzed asymmetric double-aldol reactions.
abstract: Symmetry swap: A C2 -chiral spiro diphosphine oxide (SpinPO) has been found to be highly efficient and enantioselective in the catalysis of double-aldol reactions of ketones and aldehydes to give the corresponding optically active double-aldol products, which can be readily transformed into optically active C3 - and pseudo-C3 -symmetric molecules.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032 (P. R. China).
authors.forename: Panke
authors.initials: P
authors.lastname: Zhang
authors.forename: Zhaobin
authors.initials: Z
authors.lastname: Han
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Kuiling
authors.initials: K
authors.lastname: Ding
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D058115:Lewis Bases / Q000737:chemistry; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000466:Alkadienes; D058115:Lewis Bases; D010087:Oxides; D010720:Phosphines; D013141:Spiro Compounds
keywords: aldol reactions; asymmetric catalysis; organocatalysis; phosphine oxide; spiro compounds