title: A novel semisupervised algorithm for rare prescription side effect discovery.
abstract: Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects. Side effects that occur in more than one in a thousand patients are likely to be signaled efficiently by current drug surveillance methods, however, these same methods may take decades before generating signals for rarer side effects, risking medical morbidity or mortality in patients prescribed the drug while the rare side effect is undiscovered. In this paper, we propose a novel computational metaanalysis framework for signaling rare side effects that integrates existing methods, knowledge from the web,metric learning, and semisupervised clustering. The novel framework was able to signal many known rare and serious side effects for the selection of drugs investigated, such as tendon rupture when prescribed Ciprofloxacin or Levofloxacin, renal failure with Naproxen and depression associated with Rimonabant. Furthermore, for the majority of the drugs investigated it generated signals for rare side effects at a more stringent signaling threshold than existing methods and shows the potential to become a fundamental part of post marketing surveillance to detect rare side effects.
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Reps
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Garibaldi
authors.forename: Uwe
authors.initials: U
authors.lastname: Aickelin
authors.forename: Daniele
authors.initials: D
authors.lastname: Soria
authors.forename: Jack E
authors.initials: JE
authors.lastname: Gibson
authors.forename: Richard B
authors.initials: RB
authors.lastname: Hubbard
mesh_terms: D000465:Algorithms; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008491:Medical Informatics Applications; D015233:Models, Statistical