title: Spectrum of hepatic dysfunction in 2012 dengue epidemic in Kolkata, West Bengal.
abstract: Dengue fever (DF) may present as uncomplicated dengue fever, dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Transient intense viremia is responsible for mild, moderate, or severe hepatic dysfunction. Our aim was to evaluate the spectrum of hepatic dysfunction and evidence of plasma leakage in different stages of dengue fever in this epidemic. Detailed history, physical examination, and laboratory evaluation of 1,226 serologically proved dengue patients. Patients with DF were 170 and DHF was 1,056, among which those with ALT ≥ 75 U/L were 43 and 570, respectively. Patients with ALT > 151-300, > 300-450, and > 450 U/L were 186, 77, and 34, respectively. Affected DF (n = 43) and DHF (n = 570) patients presented with symptoms and signs similar to viral hepatitis, but ascites, pleural effusion, raised INR, bleeding, and hypoalbuminemia were present only in DHF patients. In dengue fever, there was a wide range of hepatic dysfunction mimicking acute viral hepatitis.
authors.affiliation: Department General Medicine, K P C Medical College, 1 F, Raja S C Mullick Road, Kolkata, 700 089, India, asissaha2008@gmail.com.
authors.forename: Ashis Kumar
authors.initials: AK
authors.lastname: Saha
authors.forename: Somnath
authors.initials: S
authors.lastname: Maitra
authors.forename: Subhas Ch
authors.initials: SCh
authors.lastname: Hazra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008107:Liver Diseases / Q000453:epidemiology / Q000821:virology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
references.citation: Southeast Asian J Trop Med Public Health. 2000 Jun;31(2):259-63
references.pmid: 11127322
references.citation: Ann Acad Med Singap. 2008 Jan;37(1):82-3
references.pmid: 18265906
references.citation: Iran J Pediatr. 2012 Jun;22(2):231-6
references.pmid: 23056891
references.citation: Southeast Asian J Trop Med Public Health. 1987 Sep;18(3):398-406
references.pmid: 3433170
references.citation: Am J Trop Med Hyg. 2010 Oct;83(4):774-80
references.pmid: 20889864
references.citation: Br Med Bull. 2010;95:161-73
references.pmid: 20616106
references.citation: Euro Surveill. 2010 Mar 11;15(10):19509
references.pmid: 20403310
references.citation: Trans R Soc Trop Med Hyg. 2006 Jul;100(7):608-14
references.pmid: 16483623
references.citation: Indian J Pediatr. 2010 Apr;77(4):435-7
references.pmid: 20140763
references.citation: Braz J Infect Dis. 2004 Apr;8(2):156-63
references.pmid: 15361994
references.citation: J Trop Pediatr. 2000 Feb;46(1):40-3
references.pmid: 10730040
references.citation: Neurol India. 2010 Jul-Aug;58(4):585-91
references.pmid: 20739797
references.citation: Am J Trop Med Hyg. 1992 Sep;47(3):265-70
references.pmid: 1355950
references.citation: Clin Microbiol Rev. 2009 Oct;22(4):564-81
references.pmid: 19822889
references.citation: Natl Med J India. 2005 May-Jun;18(3):127-30
references.pmid: 16130612
references.citation: Trop Doct. 2008 Jan;38(1):28-30
references.pmid: 18302860