title: How microRNAs influence both hereditary and inflammatory-mediated colon cancers.
abstract: MicroRNAs have emerged as important post-translational regulators of gene expression and are involved in several physiological and pathological states including the pathogenesis of human colon cancers. In regards to tumor development, microRNAs can act as oncogenes or tumor suppressors. Two hereditary predispositions (i.e., Lynch syndrome and familial adenomatous polyposis) contribute to the development of colon cancer. In addition, individuals who suffer from inflammatory bowel diseases such as Crohn's disease or ulcerative colitis have a higher risk of developing colon cancer. Here, we discuss the occurrence of the deregulated expression of microRNAs in colon cancer that arise as a result of hereditary predisposition and inflammatory bowel disease.
authors.affiliation: Physiological Sciences Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hutchison
authors.forename: Zoe
authors.initials: Z
authors.lastname: Cohen
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Onyeagucha
authors.forename: Janet
authors.initials: J
authors.lastname: Funk
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nelson
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000235:genetics; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics; D003110:Colonic Neoplasms / Q000209:etiology / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000235:genetics; D003424:Crohn Disease / Q000150:complications / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D012307:Risk Factors
chemical_list: D035683:MicroRNAs
keywords: Crohn’s disease; FAP; HNPCC; MicroRNA; ulcerative colitis
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