title: Prognostic significance of miR-194 in endometrial cancer.
abstract: Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients.
authors.affiliation: Translational Research Laboratory Department of Pathology Stony Brook Cancer Center, Stony Brook University School of Medicine, BST-2, L-9, Room 185, Stony Brook, NY 11794, USA.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhai
authors.forename: Mihriban
authors.initials: M
authors.lastname: Karaayvaz
authors.forename: Peixin
authors.initials: P
authors.lastname: Dong
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
authors.forename: Jingfang
authors.initials: J
authors.lastname: Ju
keywords: Endometrial cancer; MiR-194
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