title: Monoterpenes with antibacterial activities from a Cameroonian medicinal plant Canthium Multiflorum (Rubiaceae).
abstract: Investigation of the crude extract obtained from the aerial parts of Canthium multiflorum led to the isolation of a new iridoid (1) together with twelve known compounds. The structures of these compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic data, accurate mass measurements and comparison with analytical data of previously known analogues. Most of the isolated compounds have been reported for the first time from C. multiflorium. The antimicrobial activities of the isolated compounds were evaluated on five different bacterial strains using agar diffusion technique. The Gram-positive bacterium Staphylococcus aureus subsp. aureus (DSM 799), and the Gram-negative bacteria Actinobacter calco-aceticus (DSM 30006), Serratia plymuthica (DSM 4540), Pseudomonas stutzeri (DSM 4166) and Escherichia coli (DSM 1116) were employed for this purpose. The new iridoid, named 6-oxo-genipin (1), demonstrated significant inhibitory activity against all microbial strains tested, especially the pathogen Staphylococcus aureus. In addition, the compounds 3, 4 and 9 exhibited antiplasmodial activity against Plasmodium falciparum strain K1 and weak cytotoxicity against L6 cell lines.
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon.
authors.forename: Simeon Fogue
authors.initials: SF
authors.lastname: Kouam
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon.
authors.forename: Alain Wembe
authors.initials: AW
authors.lastname: Ngouonpe
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors.forename: Anke
authors.initials: A
authors.lastname: Bullach
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Lamshöft
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors.forename: Guy Merlin
authors.initials: GM
authors.lastname: Kuigoua
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Spiteller
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000977:Antiparasitic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002163:Cameroon; D045744:Cell Line, Tumor; D039823:Iridoids / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: C000588651:6-oxogenipin; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000977:Antiparasitic Agents; D039823:Iridoids; D039821:Monoterpenes; D010936:Plant Extracts
keywords: Antibacterial; Antiplasmodial; Canthium multiflorum; Iridoids; Rubiaceae