title: KISS1 expression in colorectal cancer.
abstract: Kisspeptins, the products of the KISS1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis in various cancers. Herein, we studied KISS1 expression in colorectal cancer. We analyzed KISS1 expression using immunohistochemistry and image analysis in normal and malignant tissue samples from 60 patients with colorectal adenocarcinoma. The results correlated with various clinicopathological parameters. The expression of KISS1 was much higher in normal than in malignant colonic mucosa. However, among malignant tissues, KISS1 expression was higher in larger tumors (>4 cm) than in smaller ones (≤4 cm) and in stages III and IV than in stages I and II. In addition, it was higher in patients with lymph node metastases. Moreover, KISS1 levels in the normal mucosa and their difference from those in the malignant mucosa were higher in the right part of the large intestine than in the left one. KISS1 expression is reduced during the malignant transformation of the colonic mucosa and there is a difference in the expression pattern between the right and the left part of the large intestine. However, larger and advanced colorectal tumors express higher KISS1 levels than smaller and localized ones.
authors.affiliation: Second Department of Propedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School, Athens; Department of Experimental Physiology, National and Kapodistrian University of Athens, Medical School, Athens.
authors.forename: Ioannis D
authors.initials: ID
authors.lastname: Kostakis
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.forename: Aristeidis G
authors.initials: AG
authors.lastname: Vaiopoulos
authors.forename: Eleni
authors.initials: E
authors.lastname: Mylona
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.forename: Gregory
authors.initials: G
authors.lastname: Kouraklis
authors.forename: Michael
authors.initials: M
authors.lastname: Koutsilieris
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D059648:Kisspeptins / Q000235:genetics* / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D047368:Tumor Burden
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins
keywords: KISS1; colorectal cancer; immunohistochemistry; kisspeptin; large intestine