title: Pain matrices and neuropathic pain matrices: a review.
abstract: The pain matrix is conceptualised here as a fluid system composed of several interacting networks. A nociceptive matrix receiving spinothalamic projections (mainly posterior operculoinsular areas) ensures the bodily specificity of pain and is the only one whose destruction entails selective pain deficits. Transition from cortical nociception to conscious pain relies on a second-order network, including posterior parietal, prefrontal and anterior insular areas. Second-order regions are not nociceptive-specific; focal stimulation does not evoke pain, and focal destruction does not produce analgesia, but their joint activation is necessary for conscious perception, attentional modulation and control of vegetative reactions. The ensuing pain experience can still be modified as a function of beliefs, emotions and expectations through activity of third-order areas, including the orbitofrontal and perigenual/limbic networks. The pain we remember results from continuous interaction of these subsystems, and substantial changes in the pain experience can be achieved by acting on each of them. Neuropathic pain (NP) is associated with changes in each of these levels of integration. The most robust abnormality in NP is a functional depression of thalamic activity, reversible with therapeutic manoeuvres and associated with rhythmic neural bursting. Neuropathic allodynia has been associated with enhancement of ipsilateral over contralateral insular activation and lack of reactivity in orbitofrontal/perigenual areas. Although lack of response of perigenual cortices may be an epiphenomenon of chronic pain, the enhancement of ipsilateral activity may reflect disinhibition of ipsilateral spinothalamic pathways due to depression of their contralateral counterpart. This in turn may bias perceptual networks and contribute to the subjective painful experience.
authors.affiliation: Central Integration of Pain lab (NeuroPain), Centre for Neuroscience of Lyon, INSERM U1028, UMR5292, University Claude Bernard Lyon, France.
authors.forename: Luis
authors.initials: L
authors.lastname: Garcia-Larrea
authors.forename: Roland
authors.initials: R
authors.lastname: Peyron
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D009437:Neuralgia / Q000503:physiopathology*; D058748:Pain Perception / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*
keywords: Cingulate; Functional imaging; Insula; Neuropathic pain; Pain matrix; Thalamus
references.citation: Abou-Khalil BW, Siegel GJ, Sackellares JC, Gilman S, Hichwa R, Marshall R. Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy. Ann Neurol 1987;22:480-486.
references.citation: Abrahamsen R, Dietz M, Lodahl S, Roepstorff A, Zachariae R, Ostergaard L, Svensson P. Effect of hypnotic pain modulation on brain activity in patients with temporomandibular disorder pain. PAIN® 2010;151:825-833.
references.citation: Adler LJ, Gyulai FE, Diehl DJ, Mintun MA, Winter PM, Firestone LL. Regional brain activity changes associated with fentanyl analgesia elucidated by positron emission tomography. Anesth Analg 1997;84:120-126.
references.citation: Al Maskati HA, Zbrozyna AW. Stimulation in prefrontal cortex area inhibits cardiovascular and motor components of the defence reaction in rats. J Auton Nerv Syst 1989;28:117-125.
references.citation: Albe-Fessard D, Berkley KJ, Kruger L, Ralston HJ 3rd, Willis WD Jr. Diencephalic mechanisms of pain sensation. Brain Res 1985;356:217-296.
references.citation: Albuquerque RJ, de Leeuw R, Carlson CR, Okeson JP, Miller CS, Andersen AH. Cerebral activation during thermal stimulation of patients who have burning mouth disorder: an fMRI study. Pain 2006;122:223-234.
references.citation: Apkarian AV. A neural signature for pain. Trends Cogn Sci 2013;17:309-310.
references.citation: Apkarian AV, Hodge CJ. Primate spinothalamic pathways: II. The cells of origin of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 1989;288:474-492.
references.citation: Apkarian AV, Hodge CJ. Primate spinothalamic pathways: III. Thalamic terminations of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 1989;288:493-511.
references.citation: Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005;9:463-484.
references.citation: Aru J, Axmacher N, Do Lam ATA, Fell J, Elger CE, Singer W, Melloni L. Local category-specific gamma band responses in the visual cortex do not reflect conscious perception. J Neurosci 2012;32:14909-14914.
references.citation: Badre D. Cognitive control, hierarchy, and the rostro-caudal organization of the frontal lobes. Trends Cogn Sci 2008;12:193-200.
references.citation: Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how attention modulates pain in humans using functional MRI. Brain 2002;125:310-319.
references.citation: Baron R, Baron Y, Disbrow E, Roberts TP. Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study. Neurology 1999;53:548-557.
references.citation: Bartolini M, Baruffaldi R, Paolino I, Silvestrini M. Cerebral blood flow changes in the different phases of migraine. Funct Neurol 2005;20:209-211.
references.citation: Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Ann Rev Neurosci 1984;7:309-338.
references.citation: Bastuji H, Mazza S, Perchet C, Frot M, Mauguière F, Magnin M, Garcia-Larrea L. Filtering the reality: functional dissociation of lateral and medial pain systems during sleep in humans. Hum Brain Mapp 2012;33:2638-2649.
references.citation: Becerra L, Morris S, Bazes S, Gostic R, Sherman S, Gostic J, Pendse G, Moulton E, Scrivani S, Keith D, Chizh B, Borsook D. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci 2006;26:10646-10657.
references.citation: Beck DM, Rees G, Frith CD, Lavie N. Neural correlates of change detection and change blindness. Nat Neurosci 2001;4:645-650.
references.citation: Biemond A. The conduction of pain above the level of the thalamus opticus. Arch Neurol Psychiatry 1956;75:231-244.
references.citation: Bingel U, Lorenz J, Schoell E, Weiller C, Buchel C. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 2006;120:8-15.
references.citation: Blakemore SJ, Bristow D, Bird G, Frith C, Ward J. Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain 2005;128:1571-1583.
references.citation: Boivie J, Meyerson BA. A correlative anatomical and clinical study of pain suppression by deep brain stimulation. PAIN® 1982;13:113-126.
references.citation: Boly M, Faymonville ME, Schnakers C, Peigneux P, Lambermont B, Phillips C, Lancellotti P, Luxen A, Lamy M, Moonen G, Maquet P, Laureys S. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol 2008;7:1013-1020.
references.citation: Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C, Buchel C. Painful stimuli evoke different stimulus-response functions in the mygdale, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 2002;125:1326-1336.
references.citation: Borsook D, Sava S, Becerra L. The pain imaging revolution: advancing pain into the 21st century. Neuroscientist 2010;16:171-185.
references.citation: Bowsher D. Contralateral mirror-image pain following anterolateral cordotomy. PAIN® 1988;33:63-65.
references.citation: Buchel C, Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C. Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study. J Neurosci 2002;22:970-976.
references.citation: Cahana A, Carota A, Montadon ML, Annoni JM. The long-term effect of repeated intravenous lidocaine on central pain and possible correlation in positron emission tomography measurements. Anesth Analg 2004;98:1581-1584.
references.citation: Canavero S. Dynamic reverberation: a unified mechanism for central and phantom pain. Med Hypotheses 1994;42:203-207.
references.citation: Canavero S, Bonicalzi V. Bilateral central pain with unilateral brain lesion. Eur Neurol 1999;42:118.
references.citation: Canavero S, Pagni CA, Castellano G, Bonicalzi V, Bello M, Duca S, Podio V. The role of cortex in central pain syndromes: preliminary results of a long-term technetium-99 hexamethylpropyleneamineoxime single photon emission computed tomography study. Neurosurgery 1993;32:185-191.
references.citation: Caruana F, Jezzini A, Sbriscia-Fioretti B, Rizzolatti G, Gallese V. Emotional and social behaviors elicited by electrical stimulation of the insula in the macaque monkey. Curr Biol 2011;21:195-199.
references.citation: Casey KL, Geisser M, Lorenz J, Morrow TJ, Paulson P, Minoshima S. Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons. PAIN® 2012;153:331-341.
references.citation: Casse R, Rowe CC, Newton M, Berlangieri SU, Scott AM. Positron emission tomography and epilepsy. Mol Imaging Biol 2002;4:338-351.
references.citation: Cecchi GA, Huang L, Hashmi JA, Baliki M, Centeno MV, Rish I, Apkarian AV. Predictive dynamics of human pain perception. PLoS Comput Biol 2012;8:e1002719.
references.citation: Cesaro P, Amsallem B, Pollin B, Nguyen-Legros J, Moretti JL. Organization of the median and intralaminar nuclei of the thalamus: hypotheses on their role in the onset of certain central pain. Rev Neurol 1986;142:297-302.
references.citation: Cesaro P, Mann MW, Moretti JL, Defer G, Roualdés B, Nguyen JP, Degos JD. Central pain and thalamic hyperactivity: a single photon emission computerized tomographic study. PAIN® 1991;47:329-336.
references.citation: Chung JM, Lee KH, Surmeier DJ, Sorkin LS, Kim J, Willis WD. Response characteristics of neurons in the ventral posterior lateral nucleus of the monkey thalamus. J Neurophysiol 1986;56:370-390.
references.citation: Coghill RC, Sang CN, Maisog JM, Iadarola MJ. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 1999;82:1934-1943.
references.citation: Craig AD. How do you feel–now? The anterior insula and human awareness. Nat Rev Neurosci 2009;10:59-70.
references.citation: Daniele O, Fierro B, Brighina F, Magaudda A, Natalè E. Disappearance of haemorrhagic stroke-induced thalamic (central) pain following a further (contralateral ischaemic) stroke. Funct Neurol 2003;18:95-96.
references.citation: Davis KD, Kiss ZH, Luo L, Tasker RR, Lozano AM, Dostrovsky JO. Phantom sensations generated by thalamic microstimulation. Nature 1998;391:385-387.
references.citation: Davis KD, Taub E, Duffner F, Lozano AM, Tasker RR, Houle S, Dostrovsky JO. Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study. J Neurosurg 2000;92:64-69.
references.citation: De Salles AA, Bittar GT Jr. Thalamic pain syndrome: anatomic and metabolic correlation. Surg Neurol 1994;41:147-151.
references.citation: de Wied M, Verbaten MN. Affective pictures processing, attention, and pain tolerance. PAIN® 2001;90:163-172.
references.citation: Dehaene S, Naccache L. Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework. Cognition 2001;79:1-37.
references.citation: Dehaene S, Naccache L, Cohen L, Bihan DL, Mangin JF, Poline JB, Rivière D. Cerebral mechanisms of word masking and unconscious repetition priming. Nat Neurosci 2001;4:752-758.
references.citation: Dehaene S, Changeux JP, Naccache L, Sackur J, Sergent C. Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn Sci 2006;10:204-211.
references.citation: Del Cul A, Baillet S, Dehaene S. Brain dynamics underlying the nonlinear threshold for access to consciousness. PLoS Biol 2007;5:e260.
references.citation: Derbyshire SW, Osborn J. Offset analgesia is mediated by activation in the region of the periaqueductal grey and rostral ventromedial medulla. Neuroimage 2009;47:1002-1006.
references.citation: Derbyshire SWG, Jones AKP, Gyulai F, Clark S, Townsend D, Firestone LL. Pain processing during three levels of noxious stimulation produces differential patterns of central activity. PAIN® 1997;73:431-445.
references.citation: Di Piero V, Jones AKP, Iannotti F, Powell M, Perani D, Lenzi GL, Frakowiak RSJ. Chronic pain: a PET study of the central effects of percutaneous high cervical cordotomy. PAIN® 1991;46:9-12.
references.citation: Diers M, Schley MT, Rance M, Yilmaz P, Lauer L, Rukwied R, Schmelz M, Flor H. Differential central pain processing following repetitive intramuscular proton/prostaglandin E2 injections in female fibromyalgia patients and healthy controls. Eur J Pain 2011;15:716-723.
references.citation: Ducreux D, Attal N, Parker F, Bouhassira D. Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia. Brain 2006;129:963-976.
references.citation: Dum RP, Levinthal DJ, Strick PL. The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. J Neurosci 2009;29:14223-14235.
references.citation: Duncan GH, Kupers RC, Marchand S, Villemure JG, Gybels JM, Bushnell MC. Stimulation of human thalamus for pain relief: possible modulatory circuits revealed by positron emission tomography. J Neurophysiol 1998;80:3326-3330.
references.citation: Eisenberger NI, Lieberman MD. Why rejection hurts: a common neural alarm system for physical and social pain. Trends Cogn Sci 2004;8:294-300.
references.citation: Eisenberger NI, Lieberman MD, Williams KD. Does rejection hurt? An fMRI study of social exclusion. Science 2003;302:290-292.
references.citation: Etkin A, Egner T, Kalisch R. Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 2011;15:85-93.
references.citation: Faymonville ME, Roediger L, Del Fiore G, Delgueldre C, Phillips C, Lamy M, Luxen A, Maquet P, Laureys S. Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Brain Res Cogn Brain Res 2003;17:255-262.
references.citation: Firestone LL, Gyulai F, Mintun M, Adler LJ, Urso K, Winter PM. Human brain activity response to fentanyl imaged by positron emission tomography. Anesth Analg 1996;82:1247-1251.
references.citation: Fitzgibbon BM, Giummarra MJ, Georgiou-Karistianis N, Enticott PG, Bradshaw JL. Shared pain: from empathy to synaesthesia. Neurosci Biobehav Rev 2010;34:500-512.
references.citation: Frot M, Rambaud L, Guenot M, Mauguiere F. Intracortical recordings of early pain-related CO2-laser evoked potentials in the human second somatosensory (SII) area. Clin Neurophysiol 1999;110:133-145.
references.citation: Frot M, Magnin M, Mauguière F, Garcia-Larrea L. Cortical representation of pain in primary sensory-motor areas (S1/M1)-a study using intracortical recordings in humans. Hum Brain Mapp 2013;34:2655-2668.
references.citation: Fuchs E, Flügge G. Chronic social stress: effects on limbic brain structures. Physiol Behav 2003;79:417-427.
references.citation: Fukui S, Shigemori S, Nosaka S. Changes in regional cerebral blood flow in the thalamus after electroconvulsive therapy for patients with complex regional pain syndrome type 1 (preliminary case series). Reg Anesth Pain Med 2002;27:529-532.
references.citation: Fukumoto M, Ushida T, Zinchuk VS, Yamamoto Y, Yoshida S. Contralateral thalamic perfusion in patients with reflex sympathetic dystrophy syndrome. Lancet 1999;354:1790-1791.
references.citation: Garcia-Larrea L. The posterior insular-opercular region and the search of a primary cortex for pain. Neurophysiol Clin 2012;42:299-313.
references.citation: Garcia-Larrea L, Peyron R. Motor cortex stimulation for neuropathic pain: from phenomenology to mechanisms. Neuroimage 2007;37:71-79.
references.citation: Garcia-Larrea L, Bastuji H, Mauguière F. Mapping study of somatosensory evoked potentials during selective spatial attention. Electroencephalogr Clin Neurophysiol 1991;80:201-214.
references.citation: Garcia-Larrea L, Peyron R, Laurent B, Mauguiere F. Association and dissociation between laser-evoked potentials and pain perception. Neuroreport 1997;8:3785-3789.
references.citation: Garcia-Larrea L, Peyron R, Mertens P, Gregoire MC, Lavenne F, Le Bars D, Convers P, Mauguiere F, Sindou M, Laurent B. Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. PAIN® 1999;83:259-273.
references.citation: Garcia-Larrea L, Maarrawi J, Peyron R, Costes N, Mertens P, Magnin M, Laurent B. On the relation between sensory deafferentation, pain and thalamic activity in Wallenberg's syndrome: A PET-scan study before and after motor cortex stimulation. Eur J Pain 2006;10:677-688.
references.citation: Garcia-Larrea L, Perchet C, Creac'h C, Convers P, Peyron R, Laurent B, Mauguière F, Magnin M. Operculo-insular pain (parasylvian pain): a distinct central pain syndrome. Brain 2010;133:2528-2539.
references.citation: Garraghty PE, Kaas JH. Functional reorganization in adult monkey thalamus after peripheral nerve injury. Neuroreport 1991;2:747-750.
references.citation: Geha PY, Baliki MN, Chialvo DR, Harden RN, Paice JA, Apkarian AV. Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. PAIN® 2007;128:88-100.
references.citation: Geha PY, Baliki MN, Wang X, Harden RN, Paice JA, Apkarian AV. Brain dynamics for perception of tactile allodynia (touch-induced pain) in postherpetic neuralgia. PAIN® 2008;138:641-656.
references.citation: Godinho F, Magnin M, Frot M, Perchet C, Garcia-Larrea L. Emotional modulation of pain: is it the sensation or what we recall? J Neurosci 2006;26:11454-11461.
references.citation: Godinho F, Faillenot I, Perchet C, Magnin M, Garcia-Larrea L. How the pain of others enhances our pain: searching the cerebral correlates of “compassional hyperalgesia”. Eur J Pain 2012;16:748-759.
references.citation: Grant JA, Courtemanche J, Rainville P. A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators. PAIN® 2011;152:150-156.
references.citation: Greenspan JD, Lee RR, Lenz FA. Pain sensitivity alterations as a function of lesion location in the parasylvian cortex. PAIN® 1999;81:273-282.
references.citation: Gregory RL. Knowledge in perception and illusion. Philos Trans R Soc Lond B Biol Sci 1997;352:1121-1127.
references.citation: Gross J, Schmitz F, Schnitzler I, Kessler K, Shapiro K, Hommel B, Schnitzler A. Modulation of long-range neural synchrony reflects temporal limitations of visual attention in humans. Proc Natl Acad Sci U S A 2004;101:13050-13055.
references.citation: Gücer G, Niedermeyer E, Long M. Thalamic EEG recordings in patients with chronic pain. J Neurol 1978;219:47-61.
references.citation: Guedj E, Taieb D, Cammilleri S, Lussato D, de Laforte C, Niboyet J, Mundler O. 99mTc-ECD brain perfusion SPECT in hyperalgesic fibromyalgia. Eur J Nucl Med Mol Imaging 2007;34:130-134.
references.citation: Gündel H, Valet M, Sorg C, Huber D, Zimmer C, Sprenger T, Tölle TR. Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder. PAIN® 2008;137:413-421.
references.citation: Hardy SG, Holmes DE. Prefrontal stimulus-produced hypotension in rat. Exp Brain Res 1988;73:249-255.
references.citation: Harenski CL, Thornton DM, Harenski KA, Decety J, Kiehl KA. Increased frontotemporal activation during pain observation in sexual sadism: preliminary findings. Arch Gen Psychiatry 2012;69:283-292.
references.citation: Haynes JD, Driver J, Rees G. Visibility reflects dynamic changes of effective connectivity between V1 and fusiform cortex. Neuron 2005;46:811-821.
references.citation: Helmchen C, Lindig M, Petersen D, Tronnier V. Disappearance of central thalamic pain syndrome after contralateral parietal lobe lesion: implications for therapeutic brain stimulation. PAIN® 2002;98:325-330.
references.citation: Herbert C, Herbert BM, Pauli P. Emotional self-reference: brain structures involved in the processing of words describing one's own emotions. Neuropsychologia 2011;49:2947-2956.
references.citation: Hirato M, Horikoshi S, Kawashima Y, Satake K, Shibasaki T, Ohye C. The possible role of the cerebral cortex adjacent to the central sulcus for the genesis of central (thalamic) pain: a metabolic study. Acta Neurochir Suppl (Wien) 1993;58:141-144.
references.citation: Hirato M, Watanabe K, Takahashi A, Hayase N, Horikoshi S, Shibasaki T, Ohye C. Pathophysiology of central (thalamic) pain: combined change of sensory thalamus with cerebral cortex around central sulcus. Stereotact Funct Neurosurg 1994;62:300-303.
references.citation: Hirayama T, Dostrovsky JO, Gorecki J, Tasker RR, Lenz FA. Recordings of abnormal activity in patients with deafferentation and central pain. Stereotact Funct Neurosurg 1989;52:120-126.
references.citation: Hofbauer RK, Rainville P, Duncan GH, Bushnell MC. Cortical representation of the sensory dimension of pain. J Neurophysiol 2001;86:402-411.
references.citation: Hong YH, Ahn TB, Oh CW, Jeon BS. Hemichorea as an initial manifestation of moyamoya disease: reversible striatal hypoperfusion demonstrated on single photon emission computed tomography. Mov Disord 2002;17:1380-1383.
references.citation: Hsieh JC, Belfrage M, Stoneelander S, Hansson P, Ingvar M. Central representation of chronic ongoing neuropathic pain studied with positron emission tomography. PAIN® 1995;63:225-236.
references.citation: Hsieh JC, Meyerson BA, Ingvar M. PET study on central processing of pain in trigeminal neuropathy. Eur J Pain 1999;3:51-65.
references.citation: Hutchison WD, Harfa L, Dostrovsky JO. Ventrolateral orbital cortex and periaqueductal gray stimulation-induced effects on on- and off-cells in the rostral ventromedial medulla in the rat. Neuroscience 1996;70:391-407.
references.citation: Iadarola MJ, Max MB, Berman KF, Byassmith MG, Coghill RC, Gracely RH, Bennett GJ. Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain. PAIN® 1995;63:55-64.
references.citation: Iadarola MJ, Berman KF, Zeffiro TA, Byassmith MG, Gracely RH, Max MB, Bennett GJ. Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain 1997;121:931-947.
references.citation: Iannetti GD, Mouraux A. From the neuromatrix to the pain matrix (and back). Exp Brain Res 2010;205:1-12.
references.citation: Iannetti GD, Zambreanu L, Wise RG, Buchanan TJ, Huggins JP, Smart TS, Vennart W, Tracey I. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc Natl Acad Sci U S A 2005;102:18195-18200.
references.citation: Iannetti GD, Hughes NP, Lee MC, Mouraux A. Determinants of laser-evoked EEG responses: pain perception or stimulus saliency? J Neurophysiol 2008;100:815-828.
references.citation: Isnard J, Magnin M, Jung J, Mauguière F, Garcia-Larrea L. Does the insula tell our brain that we are in pain? PAIN® 2011;152:946-951.
references.citation: Ito M, Kuroda S, Shiga T, Tamaki N, Iwasaki Y. Motor cortex stimulation improves local cerebral glucose metabolism in the ipsilateral thalamus in patients with poststroke pain: case report. Neurosurgery 2011;69:E462-E469.
references.citation: Jackson PL, Meltzoff AN, Decety J. How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage 2005;24:771-779.
references.citation: Jeanmonod D, Magnin M, Morel A. Thalamus and neurogenic pain: physiological, anatomical and clinical data. Neuroreport 1993;4:475-478.
references.citation: Jeanmonod D, Magnin M, Morel A. Low-threshold calcium spike bursts in the human thalamus: common physiopathology for sensory, motor and limbic positive symptoms. Brain 1996;119:363-375.
references.citation: Jones AKP, Derbyshire SWG. PET imaging of pain-related somatosensory cortical activity. In, editors. Pain and the brain (Series. Advances in Pain Research and Therapy 1995;22:213-227.
references.citation: Jones AKP, Derbyshire SWG. Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Ann Rheum Dis 1997;56:601-607.
references.citation: Jones AKP, Brown WD, Friston KJ, Qi LY, Frakowiak RSJ. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc Roy Soc Lond (series B) 1991;244:39-44.
references.citation: Kalisch R, Wiech K, Critchley HD, Dolan RJ. Levels of appraisal: a medial prefrontal role in high-level appraisal of emotional material. Neuroimage 2006;30:1458-1466.
references.citation: Kassubek J, Juengling FD, Els T, Spreer J, Herpers M, Krause T, Moser E, Lücking CH. Activation of a residual cortical network during painful stimulation in long-term postanoxic vegetative state: a 15O–H2O PET study. J Neurol Sci 2003;212:85-91.
references.citation: Kato Y, Araki N, Matsuda H, Ito Y, Suzuki C. Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan. J Headache Pain 2010;11:255-258.
references.citation: Kim JS. Delayed-onset ipsilateral sensory symptoms in patients with central poststroke pain. Eur Neurol 1998;40:201-206.
references.citation: Kim JS. Patterns of sensory abnormality in cortical stroke: evidence for a dichotomized sensory system. Neurology 2007;68:174-180.
references.citation: Koyama S, Katayama Y, Majima S, Hirayama T, Fujii M, Tsubokawa T. Thalamic neuronal hyperactivity following transection of the spinothalamic tract in the cat: involvement of NMDA receptor. Brain Res 1993;612:343-350.
references.citation: Kross E, Berman MG, Mischel W, Smith EE, Wager TD. Social rejection shares somatosensory representations with physical pain. Proc Natl Acad Sci U S A 2011;108:6270-6275.
references.citation: Kupers R, Kehlet H. Brain imaging of clinical pain states: a critical review and strategies for future studies. Lancet Neurol 2006;5:1033-1044.
references.citation: Kupers RC, Gybels JM, Gjedde A. Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. PAIN® 2000;87:295-302.
references.citation: Kupers RC, Svensson P, Jensen TS. Central representation of muscle pain and mechanical hyperesthesia in the orofacial region: a positron emission tomography study. PAIN® 2004;108:284-293.
references.citation: Kupers R, Lonsdale MN, Aasvang E, Kehlet H. A positron emission tomography study of wind-up pain in chronic postherniotomy pain. Eur J Pain 2011;15:e1-e16.
references.citation: Kwiatek R, Barnden L, Tedman R. Regional cerebral blood flow in fibromyalgia: single photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami. Arthritis Rheum 2000;43:2823-2833.
references.citation: Lai MH, Wang TY, Chang CC, Tsai KC, Chang ST. Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion: a case of a paraplegic patient with neuropathic pain. J Clin Pharm Ther 2008;33:83-86.
references.citation: Lamm C, Decety J, Singer T. Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage 2011;54:2492-2502.
references.citation: Långsjö JW, Alkire MT, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H. Returning from oblivion: imaging the neural core of consciousness. J Neurosci 2012;32:4935-4943.
references.citation: Lanz S, Seifert F, Maihöfner C. Brain activity associated with pain, hyperalgesia and allodynia: an ALE meta-analysis. J Neural Transm 2011;118:1139-1154.
references.citation: Laterre EC, De Volder AG, Goffinet AM. Brain glucose metabolism in thalamic syndrome. J Neurol Neurosurg Psychiatry 1988;51:427-428.
references.citation: Lee MC, Zambreanu L, Menon DK, Tracey I. Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans. J Neurosci 2008;28:11642-11649.
references.citation: Legrain V, Iannetti GD, Plaghki L, Mouraux A. The pain matrix reloaded a salience detection system for the body. Prog Neurobiol 2010;93:111-124.
references.citation: Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I. The importance of context: when relative relief renders pain pleasant. PAIN® 2013;154:402-410.
references.citation: Lenz FA, Tasker RR, Dostrovsky JO, Kwan HC, Gorecki J, Hirayama T. Abnormal single-unit activity recorded in the somatosensory thalamus of a quadriplegic patient with central pain. PAIN® 1987;31:225-236.
references.citation: Lenz FA, Kwan HC, Dostrovsky JO, Tasker RR. Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain. Brain Res 1989;496:357-360.
references.citation: Lenz FA, Kwan HC, Martin R, Tasker R, Richardson RT, Dostrovsky JO. Characteristics of somatotopic organization and spontaneous neural activity in the region of the thalamic principal sensory nucleus in patients with spinal cord transection. J Neurophysiol 1994;72:1570-1587.
references.citation: Lenz FA, Gracely RH, Romanoski AJ, Hope EJ, Rowaland LH, Dougherty PM. Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. Nat Med 1995;1:910-913.
references.citation: Lenz FA, Garonzik IM, Zirh TA, Dougherty PM. Neuronal activity in the region of the thalamic principal sensory nucleus (ventralis caudalis) in patients with pain following amputations. Neuroscience 1998;86:1065-1081.
references.citation: Lenz FA, Gracely RH, Baker FH, Richardson RT, Dougherty PM. Reorganization of sensory modalities evoked by microstimulation in region of the thalamic principal sensory nucleus in patients with pain due to nervous system injury. J Comp. Neurol 1998;399:125-138.
references.citation: Lenz FA, Rios M, Zirh A, Chau D, Krauss G, Lesser RP. Painful stimuli evoke potentials recorded over the human anterior cingulate gyrus. J Neurophysiol 1998;79:2231-2234.
references.citation: Lenz FA, Rios M, Chau D, Krauss GL, Zirh TA, Lesser RP. Painful stimuli evoke potentials recorded from the parasylvian cortex in humans. J Neurophysiol 1998;80:2077-2088.
references.citation: Levesque J, Eugene F, Joanette Y, Paquette V, Mensour B, Beaudoin G. Neural circuitry underlying voluntary suppression of sadness. Biol Psychiatry 2003;53:502-510.
references.citation: Lindstedt F, Johansson B, Martinsen S, Kosek E, Fransson P, Ingvar M. Evidence for thalamic involvement in the thermal grill illusion: an FMRI study. PLoS One 2011;6(11):e27075.
references.citation: Liu CC, Shi CQ, Franaszczuk PJ, Crone NE, Schretlen D, Ohara S, Lenz FA. Painful laser stimuli induce directed functional interactions within and between the human amygdala and hippocampus. Neuroscience 2011;178:208-217.
references.citation: Llinas R, Jahnsen H. Electrophysiology of mammalian thalamic neurones in vitro. Nature 1982;297:406-408.
references.citation: Llinas RR, Ribary U, Jeanmonod D, Kronberg E, Mitra PP. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc Natl Acad Sci U S A 1999;96:15222-15227.
references.citation: Loeser JD. Pain and suffering. Clin J Pain 2000;16:S2-S6.
references.citation: Loggia ML, Mogil JS, Bushnell MC. Empathy hurts: compassion for another increases both sensory and affective components of pain perception. PAIN® 2008;136:168-176.
references.citation: Lombard MC, Nashold BS Jr, Albe-Fessard D, Salman N, Sakr C. Deafferentation hypersensitivity in the rat after dorsal rhizotomy: a possible animal model of chronic pain. PAIN® 1979;6:163-174.
references.citation: Lorenz J, Casey KL. Imaging of acute versus pathological pain in humans. Eur J Pain 2005;9:163-165.
references.citation: Lorenz J, Cross D, Minoshima S, Morrow T, Paulson P, Casey K. A unique representation of heat allodynia in the human brain. Neuron 2002;35:383-393.
references.citation: Lorenz J, Kohlhoff H, Hansen HC, Kunze K, Bromm B. Abeta-fiber mediated activation of cingulate cortex as correlate of central post-stroke pain. Neuroreport 1998;9:659-663.
references.citation: Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 2003;126:1079-1091.
references.citation: Lorenz J, Hauck M, Paur RC, Nakamura Y, Zimmermann R, Bromm B, Engel AK. Cortical correlates of false expectations during pain intensity judgments: a possible manifestation of placebo/nocebo cognitions. Brain Behav Immun 2005;19:283-295.
references.citation: Lu Y, Klein GT, Wang MY. Can pain be measured objectively? Neurosurgery 2013;73:N24-N25.
references.citation: Macdonald G, Leary MR. Why does social exclusion hurt? The relationship between social and physical pain. Psychol Bull 2005;131:202-223.
references.citation: Magnin M, Morel A, Jeanmonod D. Single-unit analysis of the pallidum, thalamus and subthalamic nucleus in parkinsonian patients. Neuroscience 2000;96:549-564.
references.citation: Magnin M, Morel A, Jeanmonod D. Toward a unified theory of positive symptoms. Neurophysiol Clin 2005;35:154-161.
references.citation: Maihofner C, Handwerker HO. Differential coding of hyperalgesia in the human brain: a functional MRI study. Neuroimage 2005;28:996-1006.
references.citation: Maihofner C, Neundorfer B, Stefan H, Handwerker HO. Cortical processing of brush-evoked allodynia. Neuroreport 2003;14:785-789.
references.citation: Maihofner C, Schmelz M, Forster C, Neundorfer B, Handwerker HO. Neural activation during experimental allodynia: a functional magnetic resonance imaging study. Eur J Neurosci 2004;19:3211-3218.
references.citation: Maihofner C, Forster C, Birklein F, Neundörfer B, Handwerker HO. Brain processing during mechanical hyperalgesia in complex regional pain syndrome: a functional MRI study. PAIN® 2005;114:93-103.
references.citation: May A, Bahra A, Büchel C, Frackowiak RS, Goadsby PJ. PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 2000;55:1328-1335.
references.citation: Mazzola L, Isnard J, Mauguiere F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans: a comparison with SI and insular responses. Cereb Cortex 2006;16:960-968.
references.citation: Mazzola L, Isnard J, Peyron R, Mauguière F. Stimulation of the human cortex and the experience of pain: Wilder Penfield's observations revisited. Brain 2012;135:631-640.
references.citation: Melzack R. Phantom limb and the concept of a neuromatrix. Trends Neurosci 1990;13:88-92.
references.citation: Merlet I, Garcia-Larrea L, Grégoire MC, Lavenne F, Mauguière F. Source propagation of interictal spikes in temporal lobe epilepsy: correlations between spike dipole modelling and [18F]fluorodeoxyglucose PET data. Brain 1996;119:377-392.
references.citation: Modesti LM, Waszak M. Firing pattern of cells in human thalamus during dorsal column stimulation. Appl Neurophysiol 1975;38:251-258.
references.citation: Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders. Biol Psychiatry 2002;51:775-787.
references.citation: Mohr C, Leyendecker S, Petersen D, Helmchen C. Effects of perceived and exerted pain control on neural activity during pain relief in experimental heat hyperalgesia: a fMRI study. Eur J Pain 2012;16:496-508.
references.citation: Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, Becerra L, Borsook D. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage 2007;35:1586-1600.
references.citation: Mountz JM, Bradley LA, Alarcon GS. Abnormal functional activity of the central nervous system in fibromyalgia syndrome. Am J Med Sci 1998;315:385-396.
references.citation: Nagaro T, Amakawa K, Kimura S, Arai T. Reference of pain following percutaneous cervical cordotomy. PAIN® 1993;53:205-211.
references.citation: Nakamura Y, Chapman CR. Measuring pain: an introspective look at introspection. Conscious Cogn 2002;11:582-592.
references.citation: Nathan PW. Reference of sensation at the spinal level. J Neurol Neurosurg Psychiatry 1956;19:88-100.
references.citation: Nicolelis MA, Lin RC, Woodward DJ, Chapin JK. Induction of immediate spatiotemporal changes in thalamic networks by peripheral block of ascending cutaneous information. Nature 1993;361:533-536.
references.citation: Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clin Neurophysiol 2004;115:1641-1652.
references.citation: Ohara S, Anderson WS, Lawson HC, Lee HT, Lenz FA. Endogenous and exogenous modulators of potentials evoked by a painful cutaneous laser (LEPs). Acta Neurochir Suppl 2006;99:77-79.
references.citation: Ohira H, Nomura M, Ichikawa N, Isowa T, Iidaka T, Sato A. Association of neural and physiological responses during voluntary emotion suppression. NeuroImage 2006;29:721-733.
references.citation: Ossipov MH, Hong Sun T, Malan P Jr, Lai J, Porreca F. Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neurosci Lett 2000;290:129-132.
references.citation: Pagni CA, Canavero S. Functional thalamic depression in a case of reversible central pain due to a spinal intramedullary cyst: case report. J Neurosurg 1995;83:163-165.
references.citation: Pessoa L. On the relationship between emotion and cognition. Nat Rev Neurosci 2008;9:148-158.
references.citation: Petrovic P, Ingvar M, Stone-Elander S, Petersson KM, Hansson P. A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. PAIN® 1999;83:459-470.
references.citation: Petrovic P, Kalso E, Magnus Petersson K, Ingvar M. Placebo and opioid analgesia. Imaging a shared neuronal network. Science 2002;295:1737-1740.
references.citation: Peyron R, Garcia-Larrea L, Deiber MP, Cinotti L, Convers P, Sindou M, Mauguiere F, Laurent B. Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study. PAIN® 1995;62:275-286.
references.citation: Peyron R, Garcia-Larrea L, Gregoire MC, Convers P, Lavenne F, Veyre L, Froment JC, Mauguiere F, Michel D, Laurent B. Allodynia after lateral-medullary (Wallenberg) infarct: A PET study. Brain 1998;121:345-356.
references.citation: Peyron R, Garcia-Larrea L, Gregoire MC, Costes N, Convers P, Lavenne F, Mauguiere F, Michel D, Laurent B. Haemodynamic brain responses to acute pain in humans: sensory and attentional networks. Brain 1999;122:1765-1780.
references.citation: Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain: a review and meta-analysis. Neurophysiol Clin 2000;30:263-288.
references.citation: Peyron R, Garcia-Larrea L, Gregoire MC, Convers P, Lavenne F, Bonnefoi F, Mauguière F, Manet L, Barral FG, Michel D, Laurent B. Parietal and cingulate processing in central pain: a positron emission tomography study. PAIN® 2000;84:77-87.
references.citation: Peyron R, Schneider F, Faillenot I, Convers P, Barral FG, Garcia-Larrea L, Laurent B. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology 2004;63:1838-1846.
references.citation: Peyron R, Faillenot I, Mertens P, Laurent B, Garcia-Larrea L. Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain: a PET study. Neuroimage 2007;34:310-321.
references.citation: Peyron R, Kupers R, Jehl JL, Garcia-Larrea L, Convers P, Barral FG, Laurent B. Central representation of the RIII flexion reflex associated with overt motor reaction: an fMRI study. Neurophysiol Clin 2007;37:249-259.
references.citation: Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception, I: the neural basis of normal emotion perception. Biol Psychiatry 2003;54:504-514.
references.citation: Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JNP. Dissociating pain from its anticipation in the human brain. Science 1999;284:1979-1981.
references.citation: Pomares FB, Faillenot I, Barral FG, Peyron R. The where and the when of the BOLD response to pain in the insular cortex: discussion on amplitudes and latencies. Neuroimage 2013;64:466-475.
references.citation: Radhakrishnan V, Tsoukatos J, Davis KD, Tasker RR, Lozano AM, Dostrovsky JO. A comparison of the burst activity of lateral thalamic neurons in chronic pain and non-pain patients. PAIN® 1999;80:567-575.
references.citation: Radley JJ, Morrison JH. Repeated stress and structural plasticity in the brain. Ageing Res Rev 2005;4:271-287.
references.citation: Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997;15:968-971.
references.citation: Rasmusson DD. Changes in the response properties of neurons in the ventroposterior lateral thalamic nucleus of the raccoon after peripheral deafferentation. J Neurophysiol 1996;75:2441-2450.
references.citation: Rausell E, Bickford L, Manger PR, Woods TM, Jones EG. Extensive divergence and convergence in the thalamocortical projection to monkey somatosensory cortex. J Neurosci 1998;18:4216-4232.
references.citation: Rees G, Wojciulik E, Clarke K, Husain M, Frith C, Driver J. Neural correlates of conscious and unconscious vision in parietal extinction. Neurocase 2002;8:387-393.
references.citation: Reynolds DV. Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 1969;164:444-445.
references.citation: Rinaldi PC, Young RF, Albe-Fessard D, Chodakiewitz J. Spontaneous neuronal hyperactivity in the medial and intralaminar thalamic nuclei of patients with deafferentation pain. J Neurosurg 1991;74:415-421.
references.citation: Saiki M, Saiki S, Gondo Y, Murata KY, Sakai K, Hirose G. Ictal alteration of 99mTc ECD SPECT imaging in a patient with secondary paroxysmal kinesigenic dyskinesia caused by hyperglycemia. Rinsho Shinkeigaku 2005;45:312-316.
references.citation: Saitoh Y, Osaki Y, Nishimura H, Hirano S, Kato A, Hashikawa K, Hatazawa J, Yoshimine T. Increased regional cerebral blood flow in the contralateral thalamus after successful motor cortex stimulation in a patient with poststroke pain. J Neurosurg 2004;100:935-939.
references.citation: Salomons TV, Johnstone T, Backonja MM, Davidson RJ. Perceived controllability modulates the neural response to pain. J Neurosci 2004;24:7199-7203.
references.citation: Sarnthein J, Jeanmonod D. High thalamocortical theta coherence in patients with neurogenic pain. Neuroimage 2008;39:1910-1917.
references.citation: Sarnthein J, Morel A, von Stein A, Jeanmonod D. Thalamic theta field potentials and EEG: high thalamocortical coherence in patients with neurogenic pain, epilepsy and movement disorders. Thalamus Rel Sys 2003;2:231-238.
references.citation: Sawamoto N, Honda M, Okada T, Hanakawa T, Kanda M, Fukuyama H, Konishi J, Shibasaki H. Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study. J Neurosci 2000;20:7438-7445.
references.citation: Schweinhardt P, Glynn C, Brooks J, McQuay H, Jack T, Chessell I, Bountra C, Tracey I. An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage 2006;32:256-265.
references.citation: Seifert F, Jungfer I, Schmelz M, Maihöfner C. Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: a functional MRI study. Hum Brain Mapp 2008;29:1327-1342.
references.citation: Seifert F, Maihöfner C. Representation of cold allodynia in the human brain – a functional MRI study. Neuroimage 2007;35:1168-1180.
references.citation: Selvarajah D, Wilkinson ID, Gandhi R, Griffiths PD, Tesfaye S. Microvascular perfusion abnormalities of the thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes. Diabetes Care 2011;34:718-720.
references.citation: Seminowicz DA, Mikulis DJ, Davis KD. Cognitive modulation of pain-related brain responses depends on behavioral strategy. PAIN® 2004;112:48-58.
references.citation: Sergent C, Baillet S, Dehaene S. Timing of the brain events underlying access to consciousness during the attentional blink. Nat Neurosci 2005;8:1391-1400.
references.citation: Shenoy R, Roberts K, Papadaki A, McRobbie D, Timmers M, Meert T, Anand P. Functional MRI brain imaging studies using the Contact Heat Evoked Potential Stimulator (CHEPS) in a human volunteer topical capsaicin pain model. J Pain Res 2011;4:365-371.
references.citation: Shin LM, Dougherty DD, Orr SP, Pitman RK, Lasko M, Macklin ML, Alpert NM, Fischman AJ, Rauch SL. Activation of anterior paralimbic structures during guilt-related script-driven imagery. Biol Psychiatry 2000;48:43-50.
references.citation: Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science 2004;303:1157-1162.
references.citation: Soria ED, Fine EJ. Disappearance of thalamic pain after parietal subcortical stroke. PAIN® 1991;44:285-288.
references.citation: Sprenger C, Eippert F, Finsterbusch J, Bingel U, Rose M, Büchel C. Attention modulates spinal cord responses to pain. Curr Biol 2012;22:1019-1022.
references.citation: Steriade M, Contreras D, Curró Dossi R, Nuñez A. The slow (<1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks. J Neurosci 1993;13:3284-3299.
references.citation: Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH. Multiple representations of pain in human cerebral cortex. Science 1991;251:1355-1358.
references.citation: Tanaka S, Osari S, Ozawa M, Yamanouchi H, Goto Y, Matsuda H, Nonaka I. Recurrent pain attacks in a 3-year-old patient with myoclonus epilepsy associated with ragged-red fibers (MERRF): a single-photon emission computed tomographic (SPECT) and electrophysiological study. Brain Dev 1997;19:205-208.
references.citation: Tattersall JE, Cervero F, Lumb BM. Viscerosomatic neurons in the lower thoracic spinal cord of the cat: excitations and inhibitions evoked by splanchnic and somatic nerve volleys and by stimulation of brain stem nuclei. J Neurophysiol 1986;56:1411-1423.
references.citation: Theodore WH, Gaillard WD. Positron emission tomography in neocortical epilepsies. Adv Neurol 2000;84:435-446.
references.citation: Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron 2007;55:377-391.
references.citation: Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM. Imaging attentional modulation of pain in the periaqueductal gray in humans. J Neurosci 2002;22:2748-2752.
references.citation: Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S. Treatment of thalamic pain by chronic motor cortex stimulation. Pacing Clin Electrophysiol 1991;14:131-134.
references.citation: Tsubokawa T, Katayama Y, Yamhamoto T, Hirayama T, Koyama S. Chronic motor cortex stimulation in patients with chronic pain. J Neurosurg 1993;78:393-401.
references.citation: Usui C, Hatta K, Doi N, Nakanishi A, Nakamura H, Nishioka K, Arai H. Brain perfusion in fibromyalgia patients and its differences between responders and poor responders to gabapentin. Arthritis Res Ther 2010;12:R64.
references.citation: Valet M, Sprenger T, Boecker H, Willoch F, Rummeny E, Conrad B, Erhard P, Tolle TR. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain: an fMRI analysis. PAIN® 2004;109:399-408.
references.citation: Vanhaudenhuyse A, Boly M, Balteau E, Schnakers C, Moonen G, Luxen A, Lamy M, Degueldre C, Brichant JF, Maquet P, Laureys S, Faymonville ME. Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study. Neuroimage 2009;47:1047-1054.
references.citation: Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 2005;6:533-544.
references.citation: Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, Kosslyn SM, Rose RM, Cohen JD. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 2004;303:1162-1167.
references.citation: Wager TD, Atlas LY, Lindquist MA, Roy M, Woo CW, Kross E. An fMRI-based neurologic signature of physical pain. N Engl J Med 2013;368:1388-1397.
references.citation: Wanigakesera V, Lee MC, Rogers R, Hu P, Tracey I. Neural correlates of an injury-free model of central sensitisation induced by opioid withdrawal in humans. J Neurosci 2011;31:2835-2842.
references.citation: Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural correlates of chronic low back pain measured by arterial spin labeling. Anesthesiology 2011;115:364-374.
references.citation: Weinand ME, Carter LP, Patton DD, Oommen KJ, Labiner DM, Talwar D. Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy. Neurosurgery 1994;35:657-664.
references.citation: Weng HR, Lee JI, Lenz FA, Schwartz A, Vierck C, Rowland L, Dougherty PM. Functional plasticity in primate somatosensory thalamus following chronic lesion of the ventral lateral spinal cord. Neuroscience 2000;101:393-401.
references.citation: Weng HR, Lenz FA, Vierck C, Dougherty PM. Physiological changes in primate somatosensory thalamus induced by deafferentation are dependent on the spinal funiculi that are sectioned and time following injury. Neuroscience 2003;116:1149-1160.
references.citation: Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G. Both of us disgusted in My insula: the common neural basis of seeing and feeling disgust. Neuron 2003;40:655-664.
references.citation: Wiech K, Seymour B, Kalisch R, Stephan KE, Koltzenburg M, Driver J, Dolan RJ. Modulation of pain processing in hyperalgesia by cognitive demand. Neuroimage 2005;27:59-69.
references.citation: Wiech K, Kalisch R, Weiskopf N, Pleger B, Stephan KE, Dolan RJ. Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain. J Neurosci 2006;26:11501-11509.
references.citation: Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception. Trends Cogn Sci 2008;12:306-313.
references.citation: Wiech K, Farias M, Kahane G, Shackel N, Tiede W, Tracey I. An fMRI study measuring analgesia enhanced by religion as a belief system. PAIN® 2008;139:467-476.
references.citation: Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I. Anterior insula integrates information about salience into perceptual decisions about pain. J Neurosci 2010;30:16324-16331.
references.citation: Wik G, Fischer H, Bragée B, Kristianson M, Fredrikson M. Retrosplenial cortical activation in the fibromyalgia syndrome. Neuroreport 2003;14:619-621.
references.citation: Willer JC, Boureau F, Albe-Fessard D. Supraspinal influences on nociceptive flexion reflex and pain sensation in man. Brain Res 1979;179:61-68.
references.citation: Willis WD, AlChaer ED, Quast MJ, Westlund KN. A visceral pain pathway in the dorsal column of the spinal cord. PNAS 1999;96:7675-7679.
references.citation: Willoch F, Gamringer U, Medele R, Steude U, Tolle TR. PET activation study: analgesia by electrostimulation of the trigeminal ganglion in patients with trigeminopathic pain: a PET activation study. PAIN® 2003;103:119-130.
references.citation: Witting N, Kupers RC, Svensson P, Arendt-Nielsen L, Gjedde A, Jensen TS. Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 2001;57:1817-1824.
references.citation: Witting N, Kupers RC, Svensson P, Jensen TS. A PET activation study of brush-evoked allodynia in patients with nerve injury pain. PAIN® 2006;120:145-154.
references.citation: Wittmann M, van Wassenhove V, Craig AD, Paulus MP. The neural substrates of subjective time dilation. Front Hum Neurosci 2010;4:2.
references.citation: Woods RP, Iacoboni M, Mazziotta JC. Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994;331:1689-1692.
references.citation: Yamashiro K, Mukawa J, Terada Y, Tomiyama N, Ishida A, Mori K, Tasker RR, Albe-Fessard D. Neurons with high-frequency discharge in the central nervous system in chronic pain. Stereotact Funct Neurosurg 1994;62:290-294.
references.citation: Yarnitsky D, Barron SA, Bental E. Disappearance of phantom pain after focal brain infarction. PAIN® 1988;32:285-287.
references.citation: Yunus MB, Young CS, Saeed SA, Mountz JM, Aldag JC. Positron emission tomography in patients with fibromyalgia syndrome and healthy controls. Arthritis Rheum 2004;51:513-518.
references.citation: Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I. A role for the brainstem in central sensitisation in humans: evidence from functional magnetic resonance imaging. PAIN® 2005;114:397-407.