title: Low prevalence of high risk human papillomavirus in normal oral mucosa by hybrid capture 2.
abstract: High risk human papillomavirus (HR-HPV) are recognized as a necessary factor to development cervical cancer. During the last decade many studies have found HR-HPV in oral squamous cell carcinoma (OSCC) and normal oral mucosa, however the association between HR-HPV and OSCC is still uncertain. The aim of the study was to determine DNA HR-HPV in normal oral cavity of healthy adults. A cross-sectional study was performed; samples from 77 patients with normal oral cavity were collected at the Dentistry school, Autonomous University of Yucatan, Merida, Yucatan, México. HR-HPV was detected by hybrid capture 2. One sample out of 77(1.2%) was positive for HR-PVH. It was from a man of 50 years old. HRHPV is present in low rate among healthy oral mucosa. Hybrid capture 2 could be a good methodology for large epidemiology studies.
authors.affiliation: Virology Laboratory, Regional Research Center "Dr. Hideyo Noguchi", Autonomous University of Yucatan , Merida, Yucatan , México.
authors.forename: Maria Del Refugio
authors.initials: Mdel R
authors.lastname: González-Losa
authors.forename: Luis
authors.initials: L
authors.lastname: Manzano-Cabrera
authors.forename: Florencio
authors.initials: F
authors.lastname: Rueda-Gordillo
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Hernández-Solís
authors.forename: Luis
authors.initials: L
authors.lastname: Puerto-Solís
keywords: Papillomavirus; high risk; hybrid capture 2; oral mucosa; squamous cell carcinoma
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