title: Pancreatic lipase inhibitory stilbenoids from the roots of Vitis vinifera.
abstract: Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC₅₀ values of 6.7 ± 0.7 µM.
authors.affiliation: Department of Food Science and Technology, Pukyong National University , Busan , Republic of Korea .
authors.forename: Young-Mog
authors.initials: YM
authors.lastname: Kim
authors.forename: Eun-Woo
authors.initials: EW
authors.lastname: Lee
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Eom
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020834:Ethnopharmacology; D007700:Kinetics; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D056910:Republic of Korea; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D034421:Sus scrofa; D027843:Vitis / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013267:Stilbenes; C577256:wilsonol C; D008049:Lipase