title: Study on carrier rate of Streptococcus pyogenes among the school children and antimicrobial susceptibility pattern of isolates.
abstract: This study was done to investigate the rate of Streptococcus pyogenes or Group A streptococcus (GAS) and antimicrobial susceptibility pattern of isolates in asymptomatic school children in Kathmandu and Sindhuli districts. Pharyngeal swabs were collected and subjected to crystal violet blood agar (CVBA). A total of 468 asymptomatic school aged children were included and 51 (10.8%) were found to be GAS carrier. Among the isolates 23 (12.0%) were from boys where 28 (10.1%) were from girls. The GAS colonization rate was statistically insignificant (P > 0.05) with sex and age sub-group, although the rate was slightly higher among the boys and age sub group 10-12 years. GAS was significantly higher in large family size (p < 0.05). Out of 51 isolates, 100.0% isolates were sensitive to antibiotic penicillin where as 7.8% and 5.8% isolates were resistant to antibiotic ampicillin and erythromycin respectively.
authors.affiliation: Kathmandu College of Science and Technology, Kathmandu, Nepal. prajapati.ameeta@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Prajapati
authors.forename: S K
authors.initials: SK
authors.lastname: Rai
authors.forename: R K
authors.initials: RK
authors.lastname: Mukhiya
authors.forename: A B
authors.initials: AB
authors.lastname: Karki
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002353:Carrier State / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D009390:Nepal / Q000453:epidemiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000453:epidemiology*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents