title: Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing.
abstract: Supramolecular chemistry presents many possible avenues for the mitigation of the effects of chemical warfare agents (CWAs), including sensing, catalysis and sequestration. To-date, efforts in this field both to study fundamental interactions between CWAs and to design and exploit host systems remain sporadic. In this tutorial review the non-covalent recognition of CWAs is considered from first principles, including taking inspiration from enzymatic systems, and gaps in fundamental knowledge are indicated. Examples of synthetic systems developed for the recognition of CWAs are discussed with a focus on the supramolecular complexation behaviour and non-covalent approaches rather than on the proposed applications.
authors.affiliation: Detection Department, Dstl Porton Down, Salisbury, SP4 0JQ, UK. msambrook@dstl.gov.uk.
authors.forename: M R
authors.initials: MR
authors.lastname: Sambrook
authors.forename: S
authors.initials: S
authors.lastname: Notman
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002384:Catalysis; D002619:Chemical Warfare Agents / Q000032:analysis* / Q000378:metabolism; D002623:Chemistry Techniques, Analytical / Q000379:methods; D056831:Coordination Complexes / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D010755:Organophosphates / Q000032:analysis* / Q000378:metabolism; D012118:Resorcinols / Q000737:chemistry
chemical_list: D002619:Chemical Warfare Agents; D056831:Coordination Complexes; D003505:Cyclodextrins; D004988:Ethers, Cyclic; D010755:Organophosphates; D012118:Resorcinols; C442939:cavitand; D000110:Acetylcholinesterase