title: Copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp2)-N bond formation of conjugated tosyl amides.
abstract: A novel copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp(2))-N bond formation with conjugated tosyl amides as starting materials is presented here. The reaction affords α-aryl-β-trifluoromethyl amides bearing a quaternary stereocenter or trifluoromethylated oxindoles in a regioselective manner.
authors.affiliation: Organic Chemistry Institute, Universität Zürich, Zürich, Switzerland.
authors.forename: Wangqing
authors.initials: W
authors.lastname: Kong
authors.forename: Maria
authors.initials: M
authors.lastname: Casimiro
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Merino
authors.forename: Cristina
authors.initials: C
authors.lastname: Nevado
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D008745:Methylation; D013237:Stereoisomerism; D014105:Tosyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000577:Amides; D007211:Indoles; D014105:Tosyl Compounds; D003300:Copper