title: One size does not fit all--bacterial cell death by antibiotics cannot be explained by the action of reactive oxygen species.
abstract: Back to square one: Two recent studies prove that reactive oxygen species (ROS) are not responsible for bacterial cell death after treatment with antibiotics. The ROS concept cannot be generalized to explain all processes resulting in cell death. The search for the mechanism of action of bacterial antibiotics must thus return to the beginning.
authors.affiliation: School of Engineering and Science, Chemistry, Jacobs University Bremen, Campusring 8, 28759 Bremen (Germany) http://www.jacobs-university.de/ses/nkuhnert. n.kuhnert@jacobs-university.de.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Kuhnert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: antibiotics; antioxidants; oxidative stress; polyphenol; reactive oxygen species