title: Development of a hybrid physiologically based pharmacokinetic model with drug-specific scaling factors in rat to improve prediction of human pharmacokinetics.
abstract: Accurate prediction of pharmacokinetics (PK) in humans has been a vital part of drug discovery. The aims of this study are to verify the usefulness of scaling factors for clearance (CL) and apparent volume of distribution at the steady state (Vss ) estimated from the difference between observed and predicted PK profiles in rats for human PK prediction, and to develop a novel hybrid physiologically based pharmacokinetic (PBPK) model with the two scaling factors. The human prediction accuracies for CL with in vitro-in vivo extrapolation and Vss with a tissue composition model were improved by using rat-scaling factors. This improvement was explainable by data that the scaling factors for CL and Vss in rats were correlated with those in humans. The predictability of plasma concentration-time profiles by the hybrid PBPK model incorporating two scaling factors was compared mainly with that by the conventional PBPK model. The hybrid PBPK model yielded higher prediction accuracy for plasma concentrations than the conventional method. Furthermore, we proposed a tiered approach using the three prediction methods, including the hybrid Dedrick approach, that were previously reported (Sayama H, Komura H, Kogayu M. 2013. Drug Metab Dispos 41:498-507), taking the available information in the individual stages of drug discovery and development into consideration.
authors.affiliation: Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Komura
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kogayu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iwaki
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood*; D010599:Pharmacokinetics; D051381:Rats
chemical_list: D004364:Pharmaceutical Preparations
keywords: ADME; PBPK modeling; in vitro-in vivo extrapolation (IVIVE); metabolic clearance; modeling and simulation; pharmacokinetics; physiological model; prediction of human pharmacokinetics; simulations; translational research