title: The genetics of multiple sclerosis: review of current and emerging candidates.
abstract: Multiple sclerosis (MS) is a complex disease in which environmental, genetic, and epigenetic factors determine the risk of developing the disease. The human leukocyte antigen region is the strongest susceptibility locus linked to MS, but it does not explain the whole heritability of the disease. To find other non-human leukocyte antigen loci associated with the disease, high-throughput genotyping, sequencing, and gene-expression studies have been performed, producing a valuable quantity of information. An overview of the genomic and expression studies is provided in this review, as well as microRNA-expression studies, highlighting the importance of combining all the layers of information in order to elucidate the causes or pathological mechanisms occurring in the disease. Genetics in MS is a promising field that is presumably going to be very productive in the next decade understanding the cross talk between all the factors contributing to the development of MS.
authors.affiliation: Multiple Sclerosis Unit, Instituto Biodonostia, San Sebastián, Spain ; Red Española de Esclerosis Múltiple (REEM), Barcelona, Spain.
authors.forename: Maider
authors.initials: M
authors.lastname: Muñoz-Culla
authors.forename: Haritz
authors.initials: H
authors.lastname: Irizar
authors.forename: David
authors.initials: D
authors.lastname: Otaegui
keywords: gene expression; genetics; microRNA; multiple sclerosis
references.citation: Nat Genet. 2009 Jul;41(7):824-8
references.pmid: 19525955
references.citation: BMJ Open. 2011 Jul 18;1(1):e000053
references.pmid: 22021740
references.citation: Cancer Biol Ther. 2007 Aug;6(8):1284-8
references.pmid: 17660710
references.citation: Eur J Immunol. 2010 Mar;40(3):888-98
references.pmid: 20148420
references.citation: Am J Hum Genet. 2007 Dec;81(6):1278-83
references.pmid: 17966091
references.citation: Nat Genet. 2009 Jul;41(7):776-82
references.pmid: 19525953
references.citation: Lancet Neurol. 2013 Feb;12(2):195-206
references.pmid: 23332363
references.citation: Neurology. 2012 Jul 31;79(5):406-11
references.pmid: 22744673
references.citation: Mult Scler. 2013 Jul;19(8):1014-21
references.pmid: 23239789
references.citation: J Dermatol Sci. 2013 Jan;69(1):61-7
references.pmid: 23142053
references.citation: Nature. 2012 Aug 23;488(7412):508-511
references.pmid: 22801493
references.citation: Bioinformatics. 2011 Feb 1;27(3):431-2
references.pmid: 21149340
references.citation: J Neuroimmunol. 2012 May 15;246(1-2):51-7
references.pmid: 22458980
references.citation: Neurology. 2012 Nov 27;79(22):2166-70
references.pmid: 23077021
references.citation: Hum Mol Genet. 2003 Sep 1;12(17):2191-9
references.pmid: 12915464
references.citation: Brain. 2011 Dec;134(Pt 12):3578-89
references.pmid: 22088562
references.citation: Ann Neurol. 2013 Mar;73(3):430-2
references.pmid: 23444327
references.citation: Ann Neurol. 2011 Dec;70(6):881-6
references.pmid: 22190362
references.citation: Ann Neurol. 2004 Mar;55(3):410-7
references.pmid: 14991819
references.citation: J Neurosci. 2011 Mar 2;31(9):3435-45
references.pmid: 21368055
references.citation: Nat Med. 2011 Jan;17(1):64-70
references.pmid: 21131957
references.citation: Neurosci Lett. 2011 Oct 17;504(1):9-12
references.pmid: 21875645
references.citation: Ann Neurol. 1999 Sep;46(3):425-8
references.pmid: 10482277
references.citation: J Clin Invest. 2012 Apr;122(4):1180-8
references.pmid: 22466660
references.citation: J Neuroimmunol. 2005 Jul;164(1-2):10-21
references.pmid: 15885809
references.citation: Immunogenetics. 2012 Feb;64(2):153-4
references.pmid: 21927869
references.citation: Cancer Res. 2006 Feb 1;66(3):1277-81
references.pmid: 16452179
references.citation: Science. 2001 Nov 23;294(5547):1731-5
references.pmid: 11721059
references.citation: Nat Immunol. 2009 Dec;10(12):1252-9
references.pmid: 19838199
references.citation: Neurol Clin. 2011 May;29(2):219-31
references.pmid: 21439438
references.citation: BMC Med Genet. 2008 Mar 19;9:17
references.pmid: 18366677
references.citation: J Med Genet. 2013 Mar;50(3):140-3
references.pmid: 23315543
references.citation: Brain. 2001 Oct;124(Pt 10):1927-38
references.pmid: 11571211
references.citation: Curr Opin Immunol. 2009 Dec;21(6):596-605
references.pmid: 19896815
references.citation: Neurosci Lett. 2012 Feb 2;508(1):4-8
references.pmid: 22108567
references.citation: Nature. 2011 Aug 10;476(7359):214-9
references.pmid: 21833088
references.citation: Hum Mol Genet. 2009 Feb 15;18(4):767-78
references.pmid: 19010793
references.citation: BMC Bioinformatics. 2011 Sep 26;12:380
references.pmid: 21943367
references.citation: Nat Neurosci. 2008 Sep;11(9):1024-34
references.pmid: 19160500
references.citation: Mol Biol Rep. 2012 May;39(5):6219-25
references.pmid: 22231906
references.citation: Int J Mol Sci. 2011;12(12):8695-712
references.pmid: 22272099
references.citation: Nature. 2012 Sep 6;489(7414):57-74
references.pmid: 22955616
references.citation: Nat Rev Immunol. 2010 Feb;10(2):111-22
references.pmid: 20098459
references.citation: PLoS One. 2009 Oct 13;4(10):e7440
references.pmid: 19823682
references.citation: J Neurosci. 2003 Oct 29;23(30):9824-32
references.pmid: 14586011
references.citation: Nat Rev Genet. 2011 Feb;12(2):99-110
references.pmid: 21245828
references.citation: Am J Hum Genet. 2010 Feb 12;86(2):285-91
references.pmid: 20159113
references.citation: Immunity. 2011 Feb 25;34(2):149-62
references.pmid: 21349428
references.citation: Nature. 2007 Oct 18;449(7164):851-61
references.pmid: 17943122
references.citation: Brain. 2009 Dec;132(Pt 12):3342-52
references.pmid: 19952055
references.citation: Mult Scler. 2012 Mar;18(3):299-304
references.pmid: 21878453
references.citation: Mult Scler. 2006 Aug;12(4):511-4
references.pmid: 16900767
references.citation: N Engl J Med. 2007 Aug 30;357(9):851-62
references.pmid: 17660530
references.citation: Lancet Neurol. 2012 Feb;11(2):189-200
references.pmid: 22265214
references.citation: Eur J Immunol. 2013 Jan;43(1):104-14
references.pmid: 23079871
references.citation: J Neuroimmunol. 2012 May 15;246(1-2):27-33
references.pmid: 22445295
references.citation: J Biol Chem. 2012 Jul 20;287(30):25049-59
references.pmid: 22665476
references.citation: PLoS One. 2012;7(5):e36140
references.pmid: 22570697
references.citation: Am J Hum Genet. 2003 Mar;72(3):710-6
references.pmid: 12557126
references.citation: Clin Immunol. 2012 Jul;144(1):70-9
references.pmid: 22659298
references.citation: Ann Neurol. 2011 Dec;70(6):897-912
references.pmid: 22190364
references.citation: Nat Rev Cancer. 2010 Jun;10(6):389-402
references.pmid: 20495573
references.citation: Nat Med. 2012 Jul;18(7):1077-86
references.pmid: 22660635
references.citation: J Immunol. 2011 Sep 1;187(5):2213-21
references.pmid: 21788439
references.citation: PLoS One. 2009 Jul 20;4(7):e6309
references.pmid: 19617918
references.citation: Ann Neurol. 2006 Mar;59(3):478-89
references.pmid: 16392116
references.citation: Nature. 2010 Apr 29;464(7293):1351-6
references.pmid: 20428171
references.citation: N Engl J Med. 2012 Jul 12;367(2):115-23
references.pmid: 22784115
references.citation: PLoS One. 2010 Aug 11;5(8):e12132
references.pmid: 20711463
references.citation: Science. 2004 Oct 22;306(5696):636-40
references.pmid: 15499007
references.citation: Brain Pathol. 2003 Oct;13(4):554-73
references.pmid: 14655760
references.citation: Mult Scler. 2012 May;18(5):569-77
references.pmid: 22127897
references.citation: J Neuroimmunol. 2010 Sep 14;226(1-2):165-71
references.pmid: 20637509