title: Diadochokinetic movements differ between patients with Huntington's disease and controls.
abstract: BACKGROUND
  Assessment of impaired motor behaviour serves as tool for diagnosis and for evaluation of progression of chronic neurodegeneration.
  
  
  METHODS
  We measured performance of rapid alternating movements, simple and complex motion series with instruments in scored, drug naïve patients with Huntington's disease and controls.
  
  
  OBJECTIVE
  To compare device outcomes with the ones of controls and to correlate them with each other and with the disease symptoms.
  
  
  RESULTS
  Patients showed lower peak velocities and longer intervals for performance of rapid alternating movements than the controls. On the right dominant side, a correlation was found between intervals needed for standardised alternating movement performance and the simple motion task outcomes in the patients. No relations to the rated disease symptoms appeared.
  
  
  CONCLUSIONS
  Execution of alternating movements is disturbed in Huntington's disease. Performance of the simple motion task and realisation of alternating motions shares a need for low cognitive efforts. Both ask for a more automated motion execution. Therefore they were related to each other to a certain extent. Execution of complex movement series asks for higher cognitive load, as it demands aiming and planning of movement series with visual input. This motion pattern does not resemble to the realisation of rapid alternating movements.
authors.affiliation: Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.affiliation: Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Saft
authors.affiliation: Department of Neurology, Herne, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Andrich
authors.affiliation: Department of Neurosurgery, Klinikum Dortmund, Dortmund, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Harati
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D013223:Statistics as Topic
keywords: Huntington's disease; Velocity; pronation; supination