title: Peptidoglycan from Staphylococcus aureus induces the overexpression of TRLs 1-8 mRNA in corneal fibroblasts, but its lipoteichoic acid and muramyl dipeptide only induced the overexpression of TLR5 or TRL9.
abstract: Lipopolysaccharide induces TLR-1-8 mRNAs over-expression in corneal fibroblast. Analyzing if other TLR-ligands can do the same, we found that peptidoglycan does, but not muramyldipeptide, lipoteichoic acid and polyI:C. This suggests that the recognition of lipopolysaccharide and peptidoglycan is enough to alert these cells against microorganisms through the over-expression of the majority TLRs.
authors.affiliation: Department of Immunology, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional , Mexico City , Mexico.
authors.forename: Sandra Rodrí
authors.initials: SR
authors.lastname: Guez-Martínez
authors.forename: Norma A
authors.initials: NA
authors.lastname: Sánchez-Zauco
authors.forename: Ivonne
authors.initials: I
authors.lastname: González-Ramírez
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cancino-Diaz
authors.forename: Mario E
authors.initials: ME
authors.lastname: Cancino-Diaz
keywords: TLRs; corneal fibroblasts; peptidoglycan
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