title: Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression.
abstract: Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of the hydroethanolic leaf extract of T. occidentalis in mouse models of convulsion, muscle relaxation, and depression. The strychnine and isoniazid convulsion, traction and climbing muscle relaxation, and forced swim and tail suspension depression tests were used in this study. The extract was administered orally (p.o.) at dose range of 25-800 mg/kg while distilled water (10 mL/kg p.o.) served as negative control. Diazepam (5 mg/kg p.o.) was used as positive control in the convulsion and muscle relaxation models while imipramine (64 mg/kg p.o.) served the same purpose in the depression tests. T. occidentalis significantly increased the onset (P<.001) and reduced the duration of convulsion (P<.05, .01) in the strychnine test and increased the time to death (P<.05, .01, .001) in the isoniazid model. The extract insignificantly increased the reaction time in the traction test while it significantly increased the time in the climbing test (P<.001). In the forced swim and tail suspension models, T. occidentalis significantly (P<.001) and dose-dependently increased the duration of immobility. The results obtained in this study suggest that the hydroethanolic leaf extract of T. occidentalis possesses anticonvulsant and muscle relaxant properties, thus justifying its folkloric use.
authors.affiliation: Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos, Nigeria .
authors.forename: Abidemi J
authors.initials: AJ
authors.lastname: Akindele
authors.forename: Mutiu Y
authors.initials: MY
authors.lastname: Ajao
authors.forename: Flora R
authors.initials: FR
authors.lastname: Aigbe
authors.forename: Uchenna S
authors.initials: US
authors.lastname: Enumah
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D019662:Cucurbitaceae / Q000737:chemistry*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D009549:Nigeria; D010936:Plant Extracts / Q000008:administration & dosage*; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D009465:Neuromuscular Agents; D010936:Plant Extracts