title: Lactational exposure to sulpiride: assessment of maternal care and reproductive and behavioral parameters of male rat pups.
abstract: Dopaminergic receptor antagonists may be used as galactagogues because they increase serum prolactin (PRL) by counteracting the inhibitory influence of dopamine on PRL secretion. The antipsychotic drug sulpiride (SUL) is documented to be effective as a galactagogue, but it is transferred through milk to the neonates. The aim of the present study was to evaluate if maternal exposure to SUL during lactation could disrupt maternal care and/or male offspring reproductive development. The dams were treated daily (gavage) with SUL 2.5mg/kg or 25mg/kg during lactation. Maternal behavior was analyzed on lactational days 5 and 10. In offspring, reproductive and behavioral parameters were analyzed at different time points. SUL treatment did not impair maternal care, but caused testicular damage in male offspring. At postnatal day 90, a reduction in testis weight, volume of seminiferous tubule and histopathological alterations such as an increased percentage of abnormal seminiferous tubules were observed. Data shows that maternal exposure to SUL during lactation may impact the reproductive development of male rats and the testes seem to be the main target organ at adulthood.
authors.affiliation: Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
authors.forename: Milene Leivas
authors.initials: ML
authors.lastname: Vieira
authors.forename: Alice Hartmann
authors.initials: AH
authors.lastname: Dos Santos
authors.forename: Luiza Sienna
authors.initials: LS
authors.lastname: Silva
authors.forename: Glaura Scantamburlo Alves
authors.initials: GS
authors.lastname: Fernandes
authors.forename: Ana Carolina Inhasz
authors.initials: AC
authors.lastname: Kiss
authors.forename: Estefânia Gastaldello
authors.initials: EG
authors.lastname: Moreira
authors.forename: Suzana de Fátima Paccola
authors.initials: Sde F
authors.lastname: Mesquita
authors.forename: Daniela Cristina Ceccatto
authors.initials: DC
authors.lastname: Gerardin
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects*; D009042:Motivation / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
chemical_list: D018492:Dopamine Antagonists; D013469:Sulpiride
keywords: Dopaminergic receptor antagonist; Galactagogue; Prostate; Testis