title: Antifungal susceptibility profile of Trichosporon isolates: correlation between CLSI and etest methodologies.
abstract: The aim of the present study was to evaluate the antifungal susceptibility profile of Trichosporon species isolated from different sources employing the Clinical and Laboratory Standards Institute (CLSI) method and E-test method. Thirty-four isolates of Trichosporon spp. and six CBS reference samples were tested for their susceptibility to Amphotericin B, 5-flucytosine, Fluconazole, Itraconazole, Voriconazole and Terbinafine. All species showed high Minimun Inhibitory Concentrations (MIC) for Itraconazole and susceptibility to Fluconazole, The comparison among the results obtained by the CLSI method and E-test revealed larger discrepancies among 5-flucytosine and Itraconazole. The present work provides epidemiological data that could influence therapeutic choices. Furthermore, the comparison between different methodologies could help to analyze results obtained by different laboratories.
authors.affiliation: Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais , Belo Horizonte, MG , Brasil.
authors.forename: Raquel M L
authors.initials: RM
authors.lastname: Lemes
authors.forename: Juliana P
authors.initials: JP
authors.lastname: Lyon
authors.forename: Leonardo M
authors.initials: LM
authors.lastname: Moreira
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: de Resende
keywords: CLSI; E-test; Trichosporon spp.; antifungal drugs
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