title: Prevalence of HCV infection among clients in community-based health settings in Hawaii, 2002-2010: assessing risk factors.
abstract: OBJECTIVE
  We sought to determine the prevalence of HCV infection and identify risk factors associated with HCV infection among at-risk clients presenting to community-based health settings in Hawaii.
  
  
  METHODS
  Clients from 23 community-based sites were administered risk factor questionnaires and screened for HCV antibodies from December 2002 through May 2010. We performed univariate and multivariate logistic regression analyses.
  
  
  RESULTS
  Of 3306 participants included in the analysis, 390 (11.8%) tested antibody positive for HCV. Highest HCV antibody prevalence (17.0%) was in persons 45 to 64 years old compared with all other age groups. Significant independent risk factors were current or prior injection drug use (P < .001), blood transfusion prior to July 1992 (P = .002), and having an HCV-infected sex partner (P = .03). Stratification by gender revealed sexual exposure to be significant for males (P = .001).
  
  
  CONCLUSIONS
  Despite Hawaii's ethnic diversity, high hepatocellular carcinoma incidence, and a statewide syringe exchange program in place since the early 1990s, our HCV prevalence and risk factor findings are remarkably consistent with those reported from the mainland United States. Hence, effective interventions identified from US mainland population studies should be generalizable to Hawaii.
authors.affiliation: Jeremy C. Porter and Alan R. Katz are with the Department of Public Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu. Heather M. Lusk is with the Adult Viral Hepatitis Prevention Program, Communicable Disease Division, Hawaii State Department of Health, Honolulu.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Porter
authors.forename: Heather M
authors.initials: HM
authors.lastname: Lusk
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003151:Community Health Centers / Q000706:statistics & numerical data; D005260:Female; D006254:Hawaii / Q000453:epidemiology; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
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