title: Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis.
abstract: Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation "Hepcon" to evaluate its hepatoprotective effects in drug induced hepatitis in experimental animals. The liver injury was introduced with over dosage of non steroidal anti-inflammatory drugs (NSAIDs) and carbon tetrachloride (CCl4). The herbo-mineral formulations "Hepcon" consist of Zingiber officinale, Piprum nigrum, Ammonium chloride and Arsenic trioxide (Hartal warqi). The aqueous extraction was administered to experimental animals. Thereafter their LFTs, IgG, and tissue pathology was studied. It was observed on the basis of biochemical and histopathological analysis that animals which were subjected to Hepcon became normal in 60 days whereas those as control group did not showed improvements and most of them died. It was concluded that the efficacy of Hepcon to treat liver injury caused by CCl4 and NSAIDs is very effective, and no side effects were noticed.
authors.affiliation: Faculty of Eastern Medicine, Hamdard University Karachi, Pakistan.
authors.forename: Muhammad Saim
authors.initials: MS
authors.lastname: Jamil
authors.forename: Zahid
authors.initials: Z
authors.lastname: Mahmood
authors.forename: Aftab
authors.initials: A
authors.lastname: Saeed
authors.forename: Amir
authors.initials: A
authors.lastname: Jamil
authors.forename: Khan
authors.initials: K
authors.lastname: Usmanghani
authors.forename: Hafiz Muhammad
authors.initials: HM
authors.lastname: Asif
authors.lastname: Sajjad-al-Hassan
authors.forename: Mahira
authors.initials: M
authors.lastname: Roohi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D028321:Plant Preparations / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; C584915:Hepcon; D028321:Plant Preparations; D002251:Carbon Tetrachloride