title: Serum adiponectin, leptin, resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  To investigate the relationship of adiponectin, leptin, resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  Group I consisted of 63 obese children with liver steatosis, group II consisted of 12 obese children with elevated serum ALT activity from group I, and group III included 85 obese children without liver steatosis.
  
  
  RESULTS
  Leptin levels were higher in the NAFLD children than in the control group. Serum RBP4 levels in obese children with NAFLD were higher than those in obese children without NAFLD and controls. Adiponectin and resistin levels were negatively correlated and RBP4 levels positively correlated with ALT activity and ultrasonographic grading.
  
  
  CONCLUSIONS
  These data suggest that adiponectin, resistin and RBP4 may have a role in the pathogenesis of NAFLD in obese children. Adiponectin, leptin, resistin and RBP4 may be suitable markers for predicting metabolic syndrome and NAFLD.
authors.affiliation: Department of Pediatrics, Division of Endocrinology, Şişli Etfal Education & Training Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Boyraz
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Durak
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D002648:Child; D005234:Fatty Liver / Q000150:complications*; D006801:Humans; D020738:Leptin / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000097:blood* / Q000150:complications; D012372:ROC Curve; D052243:Resistin / Q000097:blood; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; C101326:RBP4 protein, human; C499624:RETN protein, human; D052243:Resistin; D054839:Retinol-Binding Proteins, Plasma