title: Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study.
abstract: Esophageal cancer (EC), mainly consisting of squamous cell carcinoma (ESCC) in the Eastern world and adenocarcinoma (EAC) in the Western world, is strongly associated with dietary factors such as alcohol use. We aimed to clarify the modifying role in EC etiology in Caucasians of functional genotypes in alcohol-metabolizing enzymes. In all, 351 Caucasian patients with EC and 430 matched controls were included and polymorphisms in CYP2E1, ADH and near ALDH2 genes were determined. In contrast to the results on ESCC in mainly Asian studies, we found that functional genotypes of alcohol-metabolizing enzymes were not significantly associated with EAC or ESCC in an European population.
authors.affiliation: Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Polat
authors.initials: P
authors.lastname: Dura
authors.forename: Tineke
authors.initials: T
authors.lastname: Berkers
authors.forename: Elke M
authors.initials: EM
authors.lastname: van Veen
authors.forename: Jody
authors.initials: J
authors.lastname: Salomon
authors.forename: Rene H M
authors.initials: RH
authors.lastname: te Morsche
authors.forename: Hennie M J
authors.initials: HM
authors.lastname: Roelofs
authors.forename: Jon O
authors.initials: JO
authors.lastname: Kristinsson
authors.forename: Theo
authors.initials: T
authors.lastname: Wobbes
authors.forename: Ben J M
authors.initials: BJ
authors.lastname: Witteman
authors.forename: Adriaan C I T L
authors.initials: AC
authors.lastname: Tan
authors.forename: Joost P H
authors.initials: JP
authors.lastname: Drenth
authors.forename: Wilbert H M
authors.initials: WH
authors.lastname: Peters
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics* / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: D000431:Ethanol; D000426:Alcohol Dehydrogenase; D019392:Cytochrome P-450 CYP2E1