title: Central regulation of body-fluid homeostasis.
abstract: Body-fluid homeostasis is essential to life, and the concentration of Na(+) ([Na(+)]) and osmolality in plasma and the cerebrospinal fluid (CSF) are continuously monitored in the brain. To maintain a physiological level of Na/osmolality in body fluids, the control of Na and water intake and excretion are of prime importance. Two independent sensing systems for [Na(+)] and osmolality in circumventricular organs (CVOs) have long been postulated to be involved in the monitoring of body-fluid conditions. In the past decade, several molecules were reported as promising candidates for these sensors - Nax for the [Na(+)] sensor and transient receptor potential (TRP) channels for the osmosensor. This review presents a summary of developments in these areas over recent years.
authors.affiliation: Division of Molecular Neurobiology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji-cho, Okazaki 444-8787, Aichi, Japan; School of Life Science, The Graduate University for Advanced Studies, 5-1 Higashiyama, Myodaiji-cho, Okazaki 444-8787, Aichi, Japan. Electronic address: madon@nibb.ac.jp.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Noda
authors.forename: Hiraki
authors.initials: H
authors.lastname: Sakuta
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009997:Osmotic Pressure; D012964:Sodium / Q000097:blood / Q000134:cerebrospinal fluid; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D015222:Sodium Channels; D012964:Sodium