title: Experimental models of right heart failure: a window for translational research in pulmonary hypertension.
abstract: The right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed over the past three decades providing a particular insight in RV pathophysiology. Mechanisms involved in the transition from RV adaptive hypertrophy to maladaptive remodeling and failure in conditions of chronic RV pressure or volume overload are of a great interest but not yet completely understood. Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review.
authors.affiliation: Laboratory of Surgical Research, Marie Lannelongue Hospital, University of Paris Sud, Le Plessis Robinson, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Guihaire
authors.forename: Harm Jan
authors.initials: HJ
authors.lastname: Bogaard
authors.forename: Erwan
authors.initials: E
authors.lastname: Flécher
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Noly
authors.forename: Olaf
authors.initials: O
authors.lastname: Mercier
authors.forename: François
authors.initials: F
authors.lastname: Haddad
authors.forename: Elie
authors.initials: E
authors.lastname: Fadel
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D057170:Translational Research, Biomedical; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*; D016278:Ventricular Function, Right / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology