title: 2(5H)-Furanone: A Prospective strategy for biofouling-control in membrane biofilm bacteria by quorum sensing inhibition.
abstract: Biofouling of membranes demands costly periodic cleaning and membrane replacement. A sustainable and environmentally friendly solution for maintenance is not available and would be of great interest for many purposes including economical. As complex biofilm formation by environmental strains is the major cause of biofouling and biofilm formation in most cases are controlled by N-Acylhomoserine lactone (AHL)-mediated Quorum Sensing (QS). An effort was made to understand the appropriateness of 2(5H)-furanone, to use against biofouling of membranes. QS inhibition activity by 2(5H)-furanone was studied using bioindicator strains and known AHL of different acyl chain lengths. The biofilm inhibition was studied by growth analysis on polystyrene plate of Aeromonas hyrdrophila, an environmental biofilm strain isolated from a bio-fouled reverse osmosis (RO) membrane. Results showed a QS inhibition activity against a wide range of AHLs and also biofilm formation by 2(5H)-furanone, which is believed to act as a potential quorum inhibition agent in a bacterial biofilm community.
authors.affiliation: Department of Environmental Engineering, Konkuk University, 1 Hwayang-Dong, Gwangjin Gu, Seoul, 143-701, Republic of Korea.
authors.forename: Kannan
authors.initials: K
authors.lastname: Ponnusamy
authors.forename: Diby
authors.initials: D
authors.lastname: Paul
authors.forename: Young
authors.initials: Y
authors.lastname: Sam Kim
authors.forename: Ji Hyang
authors.initials: JH
authors.lastname: Kweon
keywords: Furanone; N-Acyl homoserine lactone; biofilm; quorum sensing; water treatment
references.citation: FEMS Microbiol Rev. 2001 Aug;25(4):365-404
references.pmid: 11524130
references.citation: J Bacteriol. 2003 Oct;185(19):5665-72
references.pmid: 13129937
references.citation: EMBO J. 2003 Feb 17;22(4):870-81
references.pmid: 12574123
references.citation: J Biol Chem. 1995 May 12;270(19):11181-9
references.pmid: 7538113
references.citation: J Antimicrob Chemother. 2004 Jun;53(6):1054-61
references.pmid: 15117922
references.citation: J Microbiol Methods. 2000 Apr;40(2):175-9
references.pmid: 10699673
references.citation: J Bacteriol. 1996 Jan;178(2):435-40
references.pmid: 8550463
references.citation: J Bacteriol. 2003 Apr;185(7):2080-95
references.pmid: 12644477
references.citation: BMC Microbiol. 2004 Jul 02;4:25
references.pmid: 15233843
references.citation: Microbiology (Reading). 1999 Feb;145 ( Pt 2):283-291
references.pmid: 10075410
references.citation: J Bacteriol. 2003 Apr;185(7):2066-79
references.pmid: 12644476
references.citation: J Bacteriol. 1995 Dec;177(23):6989-92
references.pmid: 7592496
references.citation: Appl Environ Microbiol. 1996 Nov;62(11):4284-7
references.pmid: 16535454
references.citation: J Bacteriol. 1999 Mar;181(6):1703-12
references.pmid: 10074060
references.citation: Mol Plant Microbe Interact. 1998 Nov;11(11):1119-29
references.pmid: 9805399
references.citation: J Bacteriol. 1998 Oct;180(20):5398-405
references.pmid: 9765571
references.citation: J Microbiol Methods. 2000 Mar;40(1):47-55
references.pmid: 10739342
references.citation: J Microbiol. 2005 Feb;43 Spec No:101-9
references.pmid: 15765063
references.citation: Biomaterials. 2004 Sep;25(20):5003-12
references.pmid: 15109862
references.citation: Appl Environ Microbiol. 2007 Oct;73(20):6339-44
references.pmid: 17675425
references.citation: Microbiology (Reading). 1997 Dec;143 ( Pt 12):3703-3711
references.pmid: 9421896
references.citation: Microbiology (Reading). 2000 Dec;146 Pt 12:3237-3244
references.pmid: 11101681
references.citation: Environ Microbiol. 2002 Jan;4(1):18-28
references.pmid: 11966822