title: Maternal status regulates cortical responses to the body odor of newborns.
abstract: Studies in non-human mammals have identified olfactory signals as prime mediators of mother-infant bonding and they have been linked with maternal attitudes and behavior in our own species as well. However, although the neuronal network processing infant cues has been studied for visual and auditory signals; to date, no such information exists for chemosensory signals. We contrasted the cerebral activity underlying the processing of infant odor properties in 15 women newly given birth for the first time and 15 women not given birth while smelling the body odor of unfamiliar 2 day-old newborn infants. Maternal status-dependent activity was demonstrated in the thalamus when exposed to the body odor of a newly born infant. Subsequent regions of interest analyses indicated that dopaminergic neostriatal areas are active in maternal-dependent responses. Taken together, these data suggests that body odors from 2 day-old newborns elicit activation in reward-related cerebral areas in women, regardless of their maternal status. These tentative data suggests that certain body odors might act as a catalyst for bonding mechanisms and highlights the need for future research on odor-dependent mother-infant bonding using parametric designs controlling for biological saliency and general odor perception effects.
authors.affiliation: Monell Chemical Senses Center Philadelphia, PA, USA ; Department of Clinical Neuroscience, Karolinska Institutet Stockholm, Sweden ; Department of Psychology, University of Pennsylvania PA, USA.
authors.forename: Johan N
authors.initials: JN
authors.lastname: Lundström
authors.forename: Annegret
authors.initials: A
authors.lastname: Mathe
authors.forename: Benoist
authors.initials: B
authors.lastname: Schaal
authors.forename: Johannes
authors.initials: J
authors.lastname: Frasnelli
authors.forename: Katharina
authors.initials: K
authors.lastname: Nitzsche
authors.forename: Johannes
authors.initials: J
authors.lastname: Gerber
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
keywords: body odor; bonding; fMRI; neonatal; reward
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