title: Alternatives for animal wound model systems.
abstract: In this chapter a review of animal model systems already being utilized to study normal and pathologic wound healing is provided. We also go into details on alternatives for animal wound model systems. The case is made for limitations in the various approaches. We also discuss the benefits/limitations of in vitro/ex vivo systems bringing everything up to date with our current work on developing a cell-based reporter system for diabetic wound healing.
authors.affiliation: Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Cardiff, Wales, UK.
authors.forename: Phil
authors.initials: P
authors.lastname: Stephens
authors.forename: Matthew
authors.initials: M
authors.lastname: Caley
authors.forename: Matthew
authors.initials: M
authors.lastname: Peake
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D018920:Coculture Techniques; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D009928:Organ Specificity; D012867:Skin; D046509:Tissue Culture Techniques; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology
chemical_list: D003094:Collagen