title: An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs.
abstract: An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xiu-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Guang-Qiang
authors.initials: GQ
authors.lastname: Xia
authors.forename: Xiao-Kui
authors.initials: XK
authors.lastname: Wang
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: Zheng
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.forename: Guo-Ming
authors.initials: GM
authors.lastname: Zhao
authors.forename: Song
authors.initials: S
authors.lastname: Li
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D011743:Pyrimidines
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