title: Murine models of Candida gastrointestinal colonization and dissemination.
abstract: Ninety-five percent of infectious agents enter through exposed mucosal surfaces, such as the respiratory and gastrointestinal (GI) tracts. The human GI tract is colonized with trillions of commensal microbes, including numerous Candida spp. Some commensal microbes in the GI tract can cause serious human infections under specific circumstances, typically involving changes in the gut environment and/or host immune conditions. Therefore, utilizing animal models of fungal GI colonization and dissemination can lead to significant insights into the complex pathophysiology of transformation from a commensal organism to a pathogen and host-pathogen interactions. This paper will review the methodologic approaches used for modeling GI colonization versus dissemination, the insights learned from these models, and finally, possible future directions using these animal modeling systems.
authors.affiliation: Departments of Pediatrics and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: Andrew Y
authors.initials: AY
authors.lastname: Koh
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000235:genetics / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D004195:Disease Models, Animal; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D051379:Mice / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents
references.citation: Infect Immun. 1979 Mar;23(3):764-74
references.pmid: 378837
references.citation: Adv Exp Med Biol. 1999;473:11-30
references.pmid: 10659341
references.citation: Scand J Gastroenterol. 2008;43(7):831-41
references.pmid: 18584522
references.citation: Mucosal Immunol. 2010 Jul;3(4):361-73
references.pmid: 20445503
references.citation: Infect Immun. 2005 Mar;73(3):1313-20
references.pmid: 15731028
references.citation: Infect Immun. 2004 Jan;72(1):414-29
references.pmid: 14688123
references.citation: Microb Pathog. 2003 Nov;35(5):179-87
references.pmid: 14521876
references.citation: J Med Vet Mycol. 1989;27(6):363-80
references.pmid: 2628558
references.citation: Infect Immun. 1979 Aug;25(2):702-7
references.pmid: 385504
references.citation: Nature. 2008 Oct 9;455(7214):804-7
references.pmid: 18724361
references.citation: J Exp Med. 2009 Feb 16;206(2):299-311
references.pmid: 19204111
references.citation: ISME J. 2009 Aug;3(8):944-54
references.pmid: 19369970
references.citation: J Immunol. 2011 Jul 15;187(2):733-47
references.pmid: 21666057
references.citation: Infect Immun. 1987 Nov;55(11):2689-94
references.pmid: 3666959
references.citation: Infect Immun. 1990 Apr;58(4):1093-100
references.pmid: 2180820
references.citation: Infect Immun. 2000 Apr;68(4):2363-5
references.pmid: 10722645
references.citation: Nat Med. 2008 Mar;14(3):282-9
references.pmid: 18264109
references.citation: Nat Rev Microbiol. 2011 Apr;9(4):279-90
references.pmid: 21407244
references.citation: Nat Immunol. 2007 Jan;8(1):39-46
references.pmid: 17159982
references.citation: Infect Immun. 2004 Sep;72(9):4996-5003
references.pmid: 15321991
references.citation: J Infect Dis. 1993 Apr;167(4):912-9
references.pmid: 8383723
references.citation: Antimicrob Agents Chemother. 2006 Aug;50(8):2650-7
references.pmid: 16870754
references.citation: J Oral Pathol Med. 1991 Aug;20(7):332-6
references.pmid: 1680189
references.citation: Mucosal Immunol. 2011 Mar;4(2):148-57
references.pmid: 21228770
references.citation: Infect Immun. 1997 Oct;65(10):4165-72
references.pmid: 9317023
references.citation: Infect Immun. 2012 Oct;80(10):3371-80
references.pmid: 22778094
references.citation: Med Mycol. 2001 Jun;39(3):261-8
references.pmid: 11446529
references.citation: Crit Rev Oral Biol Med. 1994;5(2):125-57
references.pmid: 7858080
references.citation: Adv Appl Microbiol. 2010;72:43-62
references.pmid: 20602987
references.citation: PLoS Pathog. 2010 Jan 08;6(1):e1000713
references.pmid: 20072605
references.citation: J Antimicrob Chemother. 1982 Oct;10(4):263-70
references.pmid: 7142076
references.citation: Curr Opin Microbiol. 2004 Aug;7(4):336-41
references.pmid: 15288621
references.citation: J Med Microbiol. 2007 Sep;56(Pt 9):1138-1144
references.pmid: 17761474
references.citation: J Infect. 2006 Mar;52(3):216-22
references.pmid: 15936825
references.citation: Annu Rev Immunol. 2011;29:1-21
references.pmid: 20936972
references.citation: Infect Immun. 2001 Oct;69(10):6110-8
references.pmid: 11553549
references.citation: PLoS One. 2010 Jan 05;5(1):e8584
references.pmid: 20052418
references.citation: Nat Rev Immunol. 2011 Dec 09;12(1):9-23
references.pmid: 22158411
references.citation: Science. 2012 Jun 8;336(6086):1314-7
references.pmid: 22674328
references.citation: J Infect Dis. 2000 Sep;182(3):955-9
references.pmid: 10950797
references.citation: Diagn Microbiol Infect Dis. 2000 Sep;38(1):21-8
references.pmid: 11025180
references.citation: J Infect Dis. 1988 May;157(5):950-8
references.pmid: 3283263
references.citation: J Physiol Pharmacol. 2006 Nov;57 Suppl 9:35-49
references.pmid: 17242486
references.citation: Sabouraudia. 1985 Aug;23(4):265-73
references.pmid: 3901329
references.citation: Microbes Infect. 1999 Dec;1(14):1169-80
references.pmid: 10580272
references.citation: Nat Immunol. 2007 Jan;8(1):31-8
references.pmid: 17159984
references.citation: Infect Immun. 2004 Nov;72(11):6206-10
references.pmid: 15501745
references.citation: Eur J Immunol. 2007 Oct;37(10):2695-706
references.pmid: 17899546
references.citation: Nat Rev Gastroenterol Hepatol. 2010 Jul;7(7):380-400
references.pmid: 20606633
references.citation: Infect Immun. 2012 Jan;80(1):150-8
references.pmid: 21986629
references.citation: Cell Host Microbe. 2009 May 8;5(5):487-97
references.pmid: 19454352
references.citation: Trends Immunol. 2002 Aug;23(8):375-8
references.pmid: 12133792
references.citation: Immunology. 2010 Apr;129(4):556-66
references.pmid: 20102413
references.citation: J Nutr. 1986 May;116(5):816-22
references.pmid: 3701459
references.citation: Antimicrob Agents Chemother. 1994 Mar;38(3):409-14
references.pmid: 8203832
references.citation: Pediatr Res. 2007 May;61(5 Pt 1):530-6
references.pmid: 17413858
references.citation: Eukaryot Cell. 2010 Jul;9(7):1075-86
references.pmid: 20435697
references.citation: Br J Haematol. 2005 Jun;129(5):569-82
references.pmid: 15916679
references.citation: Clin Infect Dis. 2012 Oct;55(7):905-14
references.pmid: 22718773
references.citation: J Hosp Infect. 2009 May;72(1):9-16
references.pmid: 19303662
references.citation: Pediatr Res. 2011 Mar;69(3):189-93
references.pmid: 21099449
references.citation: Science. 2005 Mar 25;307(5717):1915-20
references.pmid: 15790844
references.citation: Infect Immun. 2012 Dec;80(12):4216-22
references.pmid: 22988015
references.citation: J Immunol. 2009 Apr 15;182(8):4938-46
references.pmid: 19342673
references.citation: J Bacteriol. 1967 Dec;94(6):1811-6
references.pmid: 16562156
references.citation: Dtsch Arztebl Int. 2009 Dec;106(51-52):837-42
references.pmid: 20062581
references.citation: Cell Mol Immunol. 2012 May;9(3):276-86
references.pmid: 22543832
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5
references.pmid: 16033867
references.citation: PLoS One. 2012;7(7):e40888
references.pmid: 22808282
references.citation: Infect Immun. 1990 Jun;58(6):1514-7
references.pmid: 2187800
references.citation: Antimicrob Agents Chemother. 1993 Jan;37(1):51-3
references.pmid: 8431017
references.citation: Infect Immun. 1992 Nov;60(11):4907-14
references.pmid: 1399001
references.citation: J Dent Res. 2007 Feb;86(2):125-30
references.pmid: 17251510
references.citation: J Med Microbiol. 2005 Jan;54(Pt 1):87-92
references.pmid: 15591261
references.citation: Infect Immun. 1990 Nov;58(11):3813-5
references.pmid: 2228251
references.citation: Microbes Infect. 2007 Apr;9(5):615-22
references.pmid: 17383212
references.citation: Infect Immun. 1981 Feb;31(2):783-91
references.pmid: 7012021
references.citation: FEMS Immunol Med Microbiol. 2007 Oct;51(1):134-9
references.pmid: 17854475
references.citation: J Infect Dis. 2004 Aug 1;190(3):624-31
references.pmid: 15243941
references.citation: Lancet. 1968 Dec 7;2(7580):1211-4
references.pmid: 4177205
references.citation: J Bacteriol. 1969 Jun;98(3):1278-83
references.pmid: 5788704
references.citation: J Pediatr Hematol Oncol. 2005 Mar;27(3):135-40
references.pmid: 15750444
references.citation: Nat Rev Immunol. 2009 May;9(5):313-23
references.pmid: 19343057
references.citation: PLoS Pathog. 2007 Dec;3(12):e184
references.pmid: 18069889
references.citation: J Food Prot. 2000 May;63(5):638-44
references.pmid: 10826722
references.citation: Science. 2006 Aug 25;313(5790):1126-30
references.pmid: 16931762
references.citation: J Infect Dis. 2008 Apr 1;197(7):972-80
references.pmid: 18419533
references.citation: Pediatrics. 2010 Oct;126(4):e865-73
references.pmid: 20876174
references.citation: PLoS Pathog. 2010 Jan;6(1):e1000714
references.pmid: 20062524
references.citation: Nat Cell Biol. 2003 Apr;5(4):287-93
references.pmid: 12669082
references.citation: Cell. 2009 Oct 30;139(3):485-98
references.pmid: 19836068
references.citation: FEMS Microbiol Lett. 2008 Jun;283(2):129-39
references.pmid: 18422625
references.citation: PLoS Pathog. 2008 Feb 8;4(2):e35
references.pmid: 18282097
references.citation: N Engl J Med. 2009 Oct 29;361(18):1760-7
references.pmid: 19864674
references.citation: Clin Diagn Lab Immunol. 2001 Jan;8(1):192-5
references.pmid: 11139219
references.citation: Clin Infect Dis. 2001 Dec 15;33(12):1959-67
references.pmid: 11702290
references.citation: Infect Immun. 2005 Apr;73(4):2262-72
references.pmid: 15784570
references.citation: Clin Infect Dis. 2006 Jun 15;42(12):1735-42
references.pmid: 16705580