title: The role of oxidants and reactive nitrogen species in irritable bowel syndrome: a potential etiological explanation.
abstract: BACKGROUND
  The aim of this study was to evaluate the plasma concentrations of malondialdehyde (MDA) and nitric oxide (NO) and the plasma activities of oxidant and antioxidant enzymes in patients with IBS.
  
  
  METHODS
  A total of 36 patients with IBS were included in the study. Thirty-five healthy subjects were selected to form the control group. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), adenosine deaminase (AD) activities, and malondialdehyde (MDA) and nitric oxide (NO) concentrations were studied in the serum samples of all patients and controls.
  
  
  RESULTS
  Plasma XO and AD activities, and MDA and NO concentrations were significantly higher in IBS patients than in controls. The SOD, CAT, and GSH-Px activities in the serum of patients with IBS were significantly lower than that of controls.
  
  
  CONCLUSIONS
  These results suggest that lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system may play a role in the pathogenesis of IBS. Increased lipid peroxidation in IBS may be related to an increase in NO level and XO activity and a decrease in antioxidant enzymes activities. In addition, increased AD activity may have a role in immunological changes of IBS patients.
authors.affiliation: Gastroenterology Department, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
authors.forename: Rafet
authors.initials: R
authors.lastname: Mete
authors.forename: Feti
authors.initials: F
authors.lastname: Tulubas
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oran
authors.forename: Ahsen
authors.initials: A
authors.lastname: Yılmaz
authors.forename: Burcu Altindag
authors.initials: BA
authors.lastname: Avci
authors.forename: Kemal
authors.initials: K
authors.lastname: Yildiz
authors.forename: Cuneyt B
authors.initials: CB
authors.lastname: Turan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurel
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood / Q000209:etiology* / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010088:Oxidoreductases / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D009569:Nitric Oxide; D008315:Malondialdehyde; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D000243:Adenosine Deaminase
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