title: [Photodynamic therapy of bladder cancer. A new option].
abstract: BACKGROUND
  Bladder cancer (BCa) is the third most common tumor in Germany. Currently, resection therapy for superficial BCa (Ta, CIS) includes photodynamic diagnostics (PDD) using HEXVIX® for improved assessment of tumor spread. Trials using these photosensitizers for photodynamic therapy (PDT) showed only limited success. Especially low tissue penetration due to short-wave excitation was a limiting factor.
  
  
  METHODS
  This study which was funded by the German Research Foundation (DFG) examined the feasibility of the novel photosensitizer tetrahydroporphyrin-tetratosylate (THPTS) for PDT in a rat bladder cancer model.
  
  
  RESULTS
  As THPTS is very effectively excitable at a near infrared wavelength of 760 nm it is within the so-called phototherapeutic window and allows tissue penetration of up to 15 mm. Thus THPTS can also be used for PDT of larger, solid tumors as was previously demonstrated for other tumor entities. Therefore, effective treatment of even muscle-invasive bladder cancer (≥T2) may become an option using THPTS. In this current study the effectiveness and safety of THPTS-PDT was examined in an orthotopic bladder cancer rat model.
authors.affiliation: Department für Operative Medizin, Klinik und Poliklinik für Urologie, Universitätsklinikum Leipzig AöR, Liebigstraße 20, 04103, Leipzig, Deutschland, jochen.neuhaus@medizin.uni-leipzig.de.
authors.forename: J
authors.initials: J
authors.lastname: Neuhaus
authors.forename: S
authors.initials: S
authors.lastname: Schastak
authors.forename: M
authors.initials: M
authors.lastname: Berndt
authors.forename: J
authors.initials: J
authors.lastname: Walther
authors.forename: A
authors.initials: A
authors.lastname: Dietel
authors.forename: N
authors.initials: N
authors.lastname: Sieger
authors.forename: J-U
authors.initials: JU
authors.lastname: Stolzenburg
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000009:adverse effects / Q000627:therapeutic use; D011166:Porphyrins / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; C519279:tetrahydroporphyrin tetratosylate
references.citation: PLoS One. 2010 Apr 22;5(4):e10282
references.pmid: 20421983
references.citation: BJU Int. 2003 Jul;92(1):125-30
references.pmid: 12823396
references.citation: Am J Surg Pathol. 1998 Dec;22(12):1435-48
references.pmid: 9850170
references.citation: J Photochem Photobiol B. 2003 Oct 15;71(1-3):1-10
references.pmid: 14705633
references.citation: Lasers Surg Med. 2012 Jul;44(5):413-20
references.pmid: 22367582
references.citation: Urology. 1997 Aug;50(2):199-206
references.pmid: 9255289
references.citation: Zhonghua Yi Xue Za Zhi. 2005 Jul 6;85(25):1762-5
references.pmid: 16253164
references.citation: Expert Rev Clin Immunol. 2012 Jul;8(5):479-94
references.pmid: 22882222
references.citation: Zhonghua Nan Ke Xue. 2005 Feb;11(2):124-6, 129
references.pmid: 15755032
references.citation: Eur Urol. 2004 Aug;46(2):170-6
references.pmid: 15245809
references.citation: Ciba Found Symp. 1989;146:198-205; discussion 205-8
references.pmid: 2534070
references.citation: Cancer Res. 1996 May 15;56(10):2355-60
references.pmid: 8625311
references.citation: J Am Acad Dermatol. 2007 Jan;56(1):125-43
references.pmid: 17190630
references.citation: BJU Int. 2005 Jun;95(9):1206-10
references.pmid: 15892802
references.citation: Pneumologie. 2011 Jan;65(1):39-59
references.pmid: 21157688
references.citation: Aktuelle Urol. 2009 Mar;40(2):91-9
references.pmid: 19214951
references.citation: Can J Urol. 2011 Aug;18(4):5778-86
references.pmid: 21854709
references.citation: Methods Find Exp Clin Pharmacol. 2008 Jan-Feb;30(1):17-23
references.pmid: 18389094
references.citation: Photodiagnosis Photodyn Ther. 2010 Dec;7(4):213-20
references.pmid: 21112542
references.citation: Aktuelle Urol. 2010 Sep;41(5):307-15
references.pmid: 20824576
references.citation: J Urol. 2005 Nov;174(5):2016-21
references.pmid: 16217385
references.citation: Eur Urol. 2011 Jun;59(6):1009-18
references.pmid: 21454009
references.citation: Nat Rev Cancer. 2006 Jul;6(7):535-45
references.pmid: 16794636
references.citation: Cancer Biol Ther. 2006 Oct;5(10):1327-31
references.pmid: 16969083
references.citation: Head Neck. 2010 Dec;32(12):1597-604
references.pmid: 20848401
references.citation: J Clin Laser Med Surg. 1996 Oct;14(5):271-80
references.pmid: 9612193
references.citation: J Photochem Photobiol B. 2005 Mar 1;78(3):203-13
references.pmid: 15708517
references.citation: J Clin Laser Med Surg. 1998 Feb;16(1):61-8
references.pmid: 9728133