title: Effect of FASN gene on milk yield and milk composition in the Chinese Holstein dairy population.
abstract: Fatty acid synthase (FASN) is a multifunctional protein that catalyzes de novo synthesis of fatty acids in cells. It plays a key role in the lipid biosynthesis as well as in the general metabolism of all living animals. We herein investigated polymorphisms of FASN. As a result, six single nucleotide polymorphisms (SNPs) were found and then genotyped in 752 Chinese Holstein cows. It was found that g.17924A>G was non-synonymous, g.13965 C>T, g.16907 T>C and g.18663T>C were synonymous mutations and two other two SNPs, g.8948 C>T (ss491228481) and g.14439T>C (rs133498277), were in intronic sequences of the gene. All such identified SNPs were found to be associated with milk yield and composition traits (P = 0.0441 to <0.0001). Significant additive and allele substitution effects were observed for three yield traits at all six loci as well (P < 0.05 to <0.01). Complete linkage disequilibrium among the five SNPs, with the exception of g.8948 C>T, was observed.
authors.affiliation: College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.
authors.forename: M A
authors.initials: MA
authors.lastname: Alim
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: X P
authors.initials: XP
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: X G
authors.initials: XG
authors.lastname: Cui
authors.forename: S L
authors.initials: SL
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: D X
authors.initials: DX
authors.lastname: Sun
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D054890:Fatty Acid Synthase, Type I / Q000235:genetics*; D005260:Female; D005838:Genotype; D015810:Linkage Disequilibrium; D008892:Milk / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide
chemical_list: D054890:Fatty Acid Synthase, Type I
keywords: SNP; association analysis; dairy cattle; milk production traits