title: DEFB1 gene 5' untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians.
abstract: The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5'-UTR DEFB1 SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of DEFB1 gene in inflammatory bowel diseases, especially with the colonic localization of Crohn's disease.
authors.affiliation: Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil.
authors.forename: T J
authors.initials: TJ
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Jobim
authors.forename: L
authors.initials: L
authors.lastname: Segat
authors.forename: A M
authors.initials: AM
authors.lastname: Bianco
authors.forename: P H
authors.initials: PH
authors.lastname: Salim
authors.forename: P
authors.initials: P
authors.lastname: Portela
authors.forename: L F
authors.initials: LF
authors.lastname: Jobim
authors.forename: D C
authors.initials: DC
authors.lastname: Damin
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: R
authors.initials: R
authors.lastname: Roesler
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D020121:5' Untranslated Regions; D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D023083:beta-Defensins / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; C406407:DEFB1 protein, human; D023083:beta-Defensins