title: Coordination of TGF-β signaling by ubiquitylation.
abstract: In this issue, Zhang et al. (2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells.
authors.affiliation: Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, 751 23 Uppsala, Sweden; Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 751 24 Uppsala, Sweden. Electronic address: aris.moustakas@licr.uu.se.
authors.forename: Aristidis
authors.initials: A
authors.lastname: Moustakas
authors.forename: Carl-Henrik
authors.initials: CH
authors.lastname: Heldin
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D053449:TNF Receptor-Associated Factor 4 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D053449:TNF Receptor-Associated Factor 4; C506367:TRAF4 protein, human