title: Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months.
abstract: BACKGROUND
  The purpose of this paper is to report the 3-month findings of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study.
  
  
  METHODS
  Eighty eyes of 40 participants undergoing vitrectomy were enrolled. Participants underwent baseline evaluation of the study (surgical) and fellow (control) eye that included: intraocular pressure, central corneal thickness, gonioscopy, cup-to-disc ratio measurement, color fundus and optic disc photography, automated perimetry, and optical coherence tomography of the macula and optic nerve. Evaluation was repeated at 3 months. Main outcome measures were changes in macula and retinal nerve fiber layer (RNFL) thickness and intraocular pressure.
  
  
  RESULTS
  All participants completed follow-up. Mean cup-to-disc ratio of study and fellow eyes at baseline was 0.43 ± 0.2 and 0.46 ± 0.2, respectively, and 13% of participants had undiagnosed narrow angles. There was no significant change in intraocular pressure, cup-to-disc ratio, or pattern standard deviation in study eyes compared with baseline or fellow eyes at 3 months. Vision improved in all study eyes at 3 months compared with baseline (P = 0.013), but remained significantly worse than fellow eyes (P < 0.001). Central subfield and temporal peripapillary RNFL thickness were significantly greater in eyes with epiretinal membrane (P < 0.05), and resolution after surgery correlated with visual improvement (P < 0.05).
  
  
  CONCLUSIONS
  The 3-month results do not indicate any increased risk for open-angle glaucoma but suggest that a relatively high percentage of eyes may be at risk of angle closure glaucoma. Temporal RNFL thickness and central subfield were increased in eyes with epiretinal membrane, and resolution correlated with degree of visual recovery.
authors.affiliation: Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Rahul K
authors.initials: RK
authors.lastname: Reddy
authors.forename: Maziar
authors.initials: M
authors.lastname: Lalezary
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kammer
authors.forename: Rachel W
authors.initials: RW
authors.lastname: Kuchtey
authors.forename: Edward F
authors.initials: EF
authors.lastname: Cherney
authors.forename: Franco M
authors.initials: FM
authors.lastname: Recchia
authors.forename: Karen M
authors.initials: KM
authors.lastname: Joos
authors.forename: Anita
authors.initials: A
authors.lastname: Agarwal
authors.forename: Janice C
authors.initials: JC
authors.lastname: Law
keywords: epiretinal membrane; intraocular pressure; macular hole; open-angle glaucoma; vitrectomy
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