title: Prostate-specific antigen mass and free prostate-specific antigen mass for predicting the prostate volume of korean men with biopsy-proven benign prostatic hyperplasia.
abstract: OBJECTIVE
  It has been reported that prostate-specific antigen (PSA) correlates with prostate volume. Recently, some studies have reported that PSA mass (PSA adjusted for plasma volume) is more accurate than PSA at predicting prostate volume. In this study, we analyzed the accuracy of PSA and the related parameters of PSA mass, free PSA (fPSA), and fPSA mass in predicting prostate volume.
  
  
  METHODS
  We retrospectively investigated 658 patients who underwent prostate biopsy from 2006 to 2012 and had a confirmed negative biopsy result. International Prostate Symptom Score (IPSS) questionnaire, PSA, fPSA, and prostate volume were investigated. PSA mass and fPSA mass were calculated by use of established formulas. The association between PSA-related parameters and IPSS and prostate volume was assessed by using Pearson correlation coefficient and receiver operating characteristic curves.
  
  
  RESULTS
  There was no significant difference between PSA and PSA mass, fPSA, or fPSA mass in predicting prostate volume except in obese patients (p-value of PSA-PSA mass for 40 cm(3), 0.54; p-value of fPSA-fPSA mass for 40 cm(3), 0.34). fPSA performed significantly better than PSA at predicting prostate volume (p-value for 40 cm(3), <0.001). IPSS and the aforementioned PSA-related parameters were not significantly correlated.
  
  
  CONCLUSIONS
  PSA mass was not a better predictive value than PSA for estimating the prostate volume in Korean men except in obese men. This finding was also applicable to the relationship of fPSA and fPSA mass, which appeared to be more accurate predictors of prostate volume than either PSA or PSA mass.
authors.affiliation: Department of Urology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Park
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Chae
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Mi Mi
authors.initials: MM
authors.lastname: Oh
authors.forename: Cheol Yong
authors.initials: CY
authors.lastname: Yoon
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon
keywords: Benign prostatic hyperplasia; Prostate-specific antigen; ROC curve
references.citation: Lancet. 2004 Jan 10;363(9403):157-63
references.pmid: 14726171
references.citation: Med Sci Monit. 2011 Feb;17(2):CR104-9
references.pmid: 21278686
references.citation: J Urol. 1997 Aug;158(2):481-7
references.pmid: 9224329
references.citation: Eur Urol. 2013 Jul;64(1):118-40
references.pmid: 23541338
references.citation: J Urol. 1991 May;145(5):984-7
references.pmid: 2016815
references.citation: J Urol. 2006 Jul;176(1):196-9
references.pmid: 16753400
references.citation: Prostate. 2000 Dec 1;45(4):315-9
references.pmid: 11102956
references.citation: Prostate Cancer Prostatic Dis. 2007;10(2):143-8
references.pmid: 17199133
references.citation: Urology. 1999 Mar;53(3):581-9
references.pmid: 10096388
references.citation: Eur Urol. 2007 Jun;51(6):1645-52; discussion 1652-3
references.pmid: 17320271
references.citation: Urology. 2012 Nov;80(5):1088-92
references.pmid: 23107399
references.citation: BJU Int. 2006 Apr;97(4):742-6
references.pmid: 16536765
references.citation: BJU Int. 2012 Jul;110(2 Pt 2):E81-5
references.pmid: 22093144
references.citation: JAMA. 2007 Nov 21;298(19):2275-80
references.pmid: 18029831
references.citation: Int J Urol. 2012 Oct;19(10):929-35
references.pmid: 22694207
references.citation: Int Urol Nephrol. 2009 Dec;41(4):761-6
references.pmid: 19224388
references.citation: Nutrition. 1989 Sep-Oct;5(5):303-11; discussion 312-3
references.pmid: 2520314
references.citation: Urology. 2005 Apr;65(4):708-12
references.pmid: 15833513
references.citation: Eur Urol. 2000 Jul;38(1):91-5
references.pmid: 10859448
references.citation: Urology. 2004 May;63(5):905-10; discussion 910-1
references.pmid: 15134977