title: Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men.
abstract: BACKGROUND
  Several genome-wide association studies (GWAS) of prostate cancer (PCa) have identified many single nucleotide polymorphisms (SNPs) that are significantly associated with PCa risk in various racial groups. The objective of this study is to evaluate which of these SNPs are associated with PCa risk in Chinese men and estimate their strength of association.
  
  
  METHODS
  All SNPs that were reported to be associated with PCa risk in GWAS from populations of European, African American, Japanese, and Chinese descent were evaluated in 1,922 PCa cases and 2,175 controls selected from the Chinese Consortium for Prostate Cancer Genetics (ChinaPCa). A logistic regression analysis was used to estimate allelic odds ratios (ORs) of these SNPs for PCa.
  
  
  RESULTS
  Among the 53 SNPs, 50 were polymorphic in the Chinese population. Of which, 10 and 24 SNPs were significantly associated with PCa risk in Chinese men at P < 0.001 and <0.05, respectively. These 24 significant SNPs included 17, 5, and 2 SNPs that were originally discovered in European, Japanese, and Chinese descent, respectively. The estimated ORs ranged from 1.10 to 1.49 and the direction of association was consistent with previous studies. When ORs were estimated separately for PCa with Gleason score ≤7 and ≥8, a marginally significant difference in ORs was found only for two of the 24 SNPs (P = 0.02 and 0.04).
  
  
  CONCLUSIONS
  About half of PCa risk-associated SNPs identified in GWAS of various populations are associated with PCa risk in Chinese men. Information on PCa risk-associated SNPs and their ORs may facilitate risk assessment of PCa risk in Chinese men.
authors.affiliation: Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Na
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Penyin
authors.initials: P
authors.lastname: Zhang
authors.forename: Dingwei
authors.initials: D
authors.lastname: Ye
authors.forename: Chuanliang
authors.initials: C
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shao
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Chen
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Dalin
authors.initials: D
authors.lastname: He
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Fangjian
authors.initials: F
authors.lastname: Zhou
authors.forename: Jianlin
authors.initials: J
authors.lastname: Yuan
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Jun
authors.initials: J
authors.lastname: Ou-Yang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Qijun
authors.initials: Q
authors.lastname: Wu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lin
authors.forename: Haowen
authors.initials: H
authors.lastname: Jiang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Deke
authors.initials: D
authors.lastname: Jiang
authors.forename: Jielin
authors.initials: J
authors.lastname: Sun
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Ding
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Sun
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D012306:Risk
keywords: Chinese; SNPs; genome-wide association; prostate cancer
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