title: Anti-Müllerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility.
abstract: OBJECTIVE
  To investigate the consequence of salpingectomy on ovarian reserve by measuring anti-Müllerian hormone (AMH) levels before in vitro fertilization (IVF) treatment in salpingectomized women compared with nonsalpingectomized women with tubal factor infertility, women with unexplained infertility and fertile control women, and to evaluate whether AMH levels could predict IVF outcome.
  
  
  METHODS
  Cross-sectional study extended from a previous prospective study.
  
  
  METHODS
  Four university fertility clinics.
  
  
  METHODS
  Seventy-one women with infertility and 21 fertile controls.
  
  
  METHODS
  Blood sampling and IVF and embryo transfer in the following cycle.
  
  
  METHODS
  Serum AMH levels and oocytes retrieved.
  
  
  RESULTS
  Anti-Müllerian hormone levels were significantly lower in the salpingectomy infertility group (median 16.1, range 5.2-54 pmol/L) compared with the nonsalpingectomy tubal factor infertility group (median 23.4, range 3.5-50 pmol/L; p = 0.04). In all groups, AMH levels correlated positively with the number of oocytes retrieved. AMH predicted poor response (five or fewer oocytes) with a sensitivity and specificity of 90% and 70%, at a 19 pmol/L cut-off value.
  
  
  CONCLUSIONS
  Serum AMH levels were lower in salpingectomized women compared with women with tubal factor infertility and preserved Fallopian tubes, indicating that ovarian reserve might be affected by tubal surgery. Furthermore, serum AMH levels could predict a poor oocyte response (five or fewer oocytes) in the study group of infertile women.
authors.affiliation: Fertility Unit, Copenhagen University Hospital Roskilde, Roskilde, Denmark; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.
authors.forename: Anna G-A
authors.initials: AG
authors.lastname: Grynnerup
authors.forename: Anette
authors.initials: A
authors.lastname: Lindhard
authors.forename: Steen
authors.initials: S
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003430:Cross-Sectional Studies; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D009865:Oocytes / Q000502:physiology; D011446:Prospective Studies; D012372:ROC Curve; D058994:Salpingectomy / Q000009:adverse effects*; D012680:Sensitivity and Specificity
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; fertilization in vitro; ovarian reserve; salpingectomy; sensitivity and specificity