title: Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction.
abstract: OBJECTIVE
  Higher serum alkaline phosphatase (ALP) and phosphate levels are associated with atherosclerotic disease and an increased risk of cardiovascular events. However, the association of ALP/phosphate with cerebral atherosclerosis and prognosis in patients with acute stroke is not well known.
  
  
  METHODS
  In 1034 patients with first-ever acute cerebral infarction, levels of ALP and phosphate were compared with (1) cerebral atherosclerosis and (2) poor long-term functional outcomes as defined by the modified Rankin Scale>2 at 3 months after stroke onset.
  
  
  RESULTS
  ALP levels were not associated with cerebral atherosclerosis. However, higher levels of ALP were associated with a poor functional outcome (adjusted odds ratio per 1 SD, 1.25; 95% confidence interval, 1.04-1.50). Phosphate was associated with neither cerebral atherosclerosis nor functional outcome.
  
  
  CONCLUSIONS
  A higher level of ALP was not associated with cerebral atherosclerosis but was an independent prognostic factor for long-term functional outcome after acute cerebral infarction.
authors.affiliation: From the Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea (J.K.); Department of Neurology, Ewha Womans University, Seoul, Republic of Korea (T.-J.S.); and Departments of Neurology (J.K., D.S., H.S.N., Y.D.K., J.H.H.) and Biostatistics (H.S.L., C.M.N.), Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jinkwon
authors.initials: J
authors.lastname: Kim
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Song
authors.forename: Dongbeom
authors.initials: D
authors.lastname: Song
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Hyo Suk
authors.initials: HS
authors.lastname: Nam
authors.forename: Young Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Ji Hoe
authors.initials: JH
authors.lastname: Heo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D020520:Brain Infarction / Q000097:blood*; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood*
chemical_list: D010710:Phosphates; D000469:Alkaline Phosphatase
keywords: alkaline phosphatase; atherosclerosis; phosphate; stroke