title: Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
abstract: Of 235 Mycobacterium tuberculosis isolates from patients who had not received tuberculosis treatment in the Irkutsk oblast and the Sakha Republic (Yakutia), eastern Siberia, 61 (26%) were multidrug resistant. A novel strain, S 256, clustered among these isolates and carried eis-related kanamycin resistance, indicating a need for locally informed diagnosis and treatment strategies.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Zhdanova
authors.forename: Scott K
authors.initials: SK
authors.lastname: Heysell
authors.forename: Oleg
authors.initials: O
authors.lastname: Ogarkov
authors.forename: Galina
authors.initials: G
authors.lastname: Boyarinova
authors.forename: Galina
authors.initials: G
authors.lastname: Alexeeva
authors.forename: Suporn
authors.initials: S
authors.lastname: Pholwat
authors.forename: Elena
authors.initials: E
authors.lastname: Zorkaltseva
authors.forename: Eric R
authors.initials: ER
authors.lastname: Houpt
authors.forename: Eugeniy
authors.initials: E
authors.lastname: Savilov
mesh_terms: D000328:Adult; D000581:Amidohydrolases / Q000235:genetics; D019943:Amino Acid Substitution; D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D002374:Catalase / Q000235:genetics; D016000:Cluster Analysis; D027081:DNA Gyrase / Q000235:genetics; D012321:DNA-Directed RNA Polymerases; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D018598:Minisatellite Repeats; D058885:Multilocus Sequence Typing; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics; D010430:Pentosyltransferases / Q000235:genetics; D015995:Prevalence; D012800:Siberia / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; C505805:rpoB protein, Mycobacterium tuberculosis; D010088:Oxidoreductases; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; C085257:InhA protein, Mycobacterium; C540269:EmbB protein, Mycobacterium tuberculosis; D010430:Pentosyltransferases; D012321:DNA-Directed RNA Polymerases; D000581:Amidohydrolases; C487496:PncA protein, Mycobacterium tuberculosis; D027081:DNA Gyrase
keywords: HIV; MDR TB; MIRU-VNTR; Russian Federation; Siberia; genotype; multidrug-resistant tuberculosis; mycobacterial interspersed repetitive unit; pncA; pyrazinamide; tuberculosis; tuberculosis and other mycobacteria
references.citation: Expert Rev Mol Diagn. 2012 May;12(4):395-405
references.pmid: 22616704
references.citation: AIDS Res Hum Retroviruses. 2001 Feb 10;17(3):257-61
references.pmid: 11177409
references.citation: Antimicrob Agents Chemother. 2011 May;55(5):2032-41
references.pmid: 21300839
references.citation: J Clin Microbiol. 2009 Jun;47(6):1767-72
references.pmid: 19386845
references.citation: J Med Microbiol. 2011 Jul;60(Pt 7):1003-1009
references.pmid: 21436372
references.citation: Nucleic Acids Res. 2010 Jul;38(Web Server issue):W326-31
references.pmid: 20457747
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2869-73
references.pmid: 16477032
references.citation: J Clin Microbiol. 2008 Nov;46(11):3576-84
references.pmid: 18753356
references.citation: Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6526-31
references.pmid: 21464295
references.citation: Infect Genet Evol. 2012 Jun;12(4):755-66
references.pmid: 22365971
references.citation: Antimicrob Agents Chemother. 2012 Jun;56(6):3114-20
references.pmid: 22470112