title: [Prophylaxis and therapy of post-traumatic stress disorder with propranolol: evidence and ethical analysis].
abstract: The beta-antagonistic agent propranolol is increasingly being used in clinical trials for the prophylaxis and treatment of post-traumatic stress disorder (PTSD). This article discusses the evidence for the effectiveness of propranolol in the prophylaxis and treatment of PTSD and the ethical implications of research on these treatment approaches. The efficacy of a prophylactic or therapeutic use could not be shown during the last decade. Both treatment approaches raise ethical questions that should already be addressed during the clinical trials.
authors.affiliation: Institut für Ethik, Geschichte und Theorie der Medizin, Ludwig-Maximilians-Universität München, Lessingstr. 2, 80336, München, Deutschland, katja.kuehlmeyer@med.lmu.de.
authors.forename: K
authors.initials: K
authors.lastname: Kühlmeyer
authors.forename: R J
authors.initials: RJ
authors.lastname: Jox
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004992:Ethics, Medical; D019317:Evidence-Based Medicine / Q000941:ethics*; D006801:Humans; D007258:Informed Consent; D061212:Memory, Episodic; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D011613:Psychotherapy; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000517:prevention & control* / Q000523:psychology
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
references.citation: N Engl J Med. 1989 Jan 26;320(4):221-7
references.pmid: 2643048
references.citation: CNS Neurosci Ther. 2012 Jan;18(1):21-7
references.pmid: 22070357
references.citation: Cerebrum. 2006 Sep;:2-11
references.pmid: 17152131
references.citation: Ann N Y Acad Sci. 2004 Dec;1032:158-66
references.pmid: 15677403
references.citation: Biol Psychiatry. 2003 Nov 1;54(9):947-9
references.pmid: 14573324
references.citation: Biol Psychiatry. 2004 Mar 15;55(6):627-33
references.pmid: 15013832
references.citation: Biol Psychiatry. 2001 Dec 15;50(12):978-85
references.pmid: 11750894
references.citation: Nervenarzt. 2011 Jul;82(7):834-41
references.pmid: 20625699
references.citation: Neurobiol Learn Mem. 2009 Jan;91(1):23-31
references.pmid: 18761097
references.citation: Neuroimage. 2005 Feb 1;24(3):898-909
references.pmid: 15652324
references.citation: Nature. 1994 Oct 20;371(6499):702-4
references.pmid: 7935815
references.citation: J Clin Psychopharmacol. 2011 Aug;31(4):547-50
references.pmid: 21720237
references.citation: Eur J Psychotraumatol. 2012;3:
references.pmid: 22893836
references.citation: Front Behav Neurosci. 2010 Dec 20;4:190
references.pmid: 21283530
references.citation: J Anxiety Disord. 2013 Jan;27(1):33-46
references.pmid: 23247200
references.citation: Neurobiol Learn Mem. 2000 Nov;74(3):259-66
references.pmid: 11031131
references.citation: J Trauma Stress. 2008 Oct;21(5):455-62
references.pmid: 18956444
references.citation: J Thorac Cardiovasc Surg. 2006 Feb;131(2):277-82
references.pmid: 16434254
references.citation: Ann N Y Acad Sci. 2006 Dec;1093:321-38
references.pmid: 17312266
references.citation: Biol Psychiatry. 2002 Jan 15;51(2):189-92
references.pmid: 11822998
references.citation: Am J Bioeth. 2007 Sep;7(9):37-8
references.pmid: 17849340
references.citation: J Trauma Stress. 2007 Dec;20(6):923-32
references.pmid: 18157888
references.citation: Am J Bioeth. 2007 Sep;7(9):12-20
references.pmid: 17849331
references.citation: Depress Anxiety. 2008;25(3):260-71
references.pmid: 17354267
references.citation: J Neurosci. 2007 Nov 7;27(45):12358-66
references.pmid: 17989300
references.citation: J Psychiatr Res. 2008 May;42(6):503-6
references.pmid: 17588604
references.citation: Tex Heart Inst J. 1997;24(4):336-42
references.pmid: 9456487