title: Rapid removal of matrices from small-volume samples by step-voltage nanoelectrospray.
abstract: Matrix unloaded: By changing from fixed-voltage (left) to step-voltage nanoelectrospray (right), the mass-spectrometric analysis of small-volume physiological samples is possible. Separation and ionization are achieved in one process, which avoids sample loss and dilution and prevents interference by the matrix. The result is high sensitivity even for samples at the nanoliter level.
authors.affiliation: Department of Chemistry, Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084 (China).
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Wei
authors.forename: Shuo
authors.initials: S
authors.lastname: Han
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Gong
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Chengdui
authors.initials: C
authors.lastname: Yang
authors.forename: Sichun
authors.initials: S
authors.lastname: Zhang
authors.forename: Xinrong
authors.initials: X
authors.lastname: Zhang
keywords: analytical methods; electromigration; mass spectrometry; matrix interference; matrix removal