title: Candida isolates in tertiary hospitals in northeastern Brazil.
abstract: Candida is an opportunistic pathogen that affects high-risk patients who are either immunocompromised or critically ill and is associated with almost 80% of all nosocomial fungal infections, representing the major cause of fungemia with high mortality rates (40%). Candida albicans is the main cause of candidemia and among the non-albicans species C. parapsilosis, C. glabrata and C. tropicalis are the most frequent agents. The aim of this study was to evaluate the distribution of Candida species in two tertiary hospitals in Recife, Northeastern Brazil. It began by surveying all positive Candida cultures processed by the microbiology laboratory from September 2003 to September 2006. The cultures, originated from various types of biological material (blood, urine, tracheal, catheter and others), were processed by Vitec (®) system (Biomerieux SA, France). A total of 1.279 (hospital A: 837; hospital B: 442) sample isolates were positive for Candida. The most frequent species in both hospitals were: C. albicans (367), C. tropicalis (363), C. parapsilosis (147), C. glabrata (81), C. krusei (30) and C. guillermondii (14). The isolates were obtained from 746 hospitalized patients. A total of 221 positive hemocultures were detected in 166 different patients in both hospitals, and 113 (68.1%) of these patients with positive hemocultures presented Candida in other body sites. This study shows that Candida non-albicans was the main isolated agent and evidences the importante of C. tropicalis in nosocomial fungal infections.
authors.affiliation: Núcleo de Ensino, Pesquisa e Assistência em Infectologia, Universidade Federal de Pernambuco , Recife, PE , Brasil.
authors.forename: Sylvia Lemos
authors.initials: SL
authors.lastname: Hinrichsen
authors.forename: Erica
authors.initials: E
authors.lastname: Falcão
authors.forename: Tatiana Aguiar Santos
authors.initials: TA
authors.lastname: Vilella
authors.forename: Leandro
authors.initials: L
authors.lastname: Rêgo
authors.forename: Conceição
authors.initials: C
authors.lastname: Lira
authors.forename: Luciano
authors.initials: L
authors.lastname: Almeida
authors.forename: Mízia
authors.initials: M
authors.lastname: Martins
authors.forename: Carmem
authors.initials: C
authors.lastname: Araújo
authors.forename: Marcelo
authors.initials: M
authors.lastname: Duarte
authors.forename: Geraldo
authors.initials: G
authors.lastname: Lopes
keywords: Candida; candida isolates; candidemia
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