title: Antibodies in HIV-1 vaccine development and therapy.
abstract: Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1-neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.
authors.affiliation: Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. fklein@rockefeller.edu
authors.forename: Florian
authors.initials: F
authors.lastname: Klein
authors.forename: Hugo
authors.initials: H
authors.lastname: Mouquet
authors.forename: Pia
authors.initials: P
authors.lastname: Dosenovic
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Scheid
authors.forename: Louise
authors.initials: L
authors.lastname: Scharf
authors.forename: Michel C
authors.initials: MC
authors.lastname: Nussenzweig
mesh_terms: D016915:AIDS Vaccines / Q000627:therapeutic use*; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control / Q000628:therapy*; D057134:Antibodies, Neutralizing / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000628:therapy*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D014759:Viral Envelope Proteins / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D014759:Viral Envelope Proteins
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