title: Temperature-activated nucleic acid nanostructures.
abstract: DNA and poly(N-isopropylacrylamide) are co-assembled onto gold nanoparticles. The DNA sequences can be reversibly exposed or hidden from the polymer surface in response to temperature cues, thereby translating the temperature trigger to the on-off switching of the surface chemistry and function. When exposed by heating (∼30 °C), the DNA rapidly hybridizes to complementary strands, and chain-end biotin groups become readily accessible, while at lower temperatures these activities are largely blocked.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University , 360 Huntington Ave, Boston, Massachusetts 02115, United States.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhu
authors.forename: Fei
authors.initials: F
authors.lastname: Jia
authors.forename: Evelyn
authors.initials: E
authors.lastname: Auyeung
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006046:Gold; D053768:Metal Nanoparticles; D013696:Temperature
chemical_list: D000180:Acrylic Resins; C052970:poly-N-isopropylacrylamide; D006046:Gold; D004247:DNA
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