title: Opsin, a structural model for olfactory receptors?
abstract: Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.
authors.affiliation: Division of Biotechnology, Advanced Institute of Environment and Bioscience, College of Environmental & Bioresources Sciences, Chonbuk National University, 570-752 Iksan (Republic of Korea). junghee.park@jbnu.ac.kr.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Takefumi
authors.initials: T
authors.lastname: Morizumi
authors.forename: Yafang
authors.initials: Y
authors.lastname: Li
authors.forename: Joo Eun
authors.initials: JE
authors.lastname: Hong
authors.forename: Emil F
authors.initials: EF
authors.lastname: Pai
authors.forename: Klaus Peter
authors.initials: KP
authors.lastname: Hofmann
authors.forename: Hui-Woog
authors.initials: HW
authors.lastname: Choe
authors.forename: Oliver P
authors.initials: OP
authors.lastname: Ernst
mesh_terms: D006801:Humans; D008958:Models, Molecular; D018034:Olfactory Receptor Neurons / Q000737:chemistry* / Q000378:metabolism; D055355:Opsins / Q000737:chemistry* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism
chemical_list: D055355:Opsins; D043562:Receptors, G-Protein-Coupled
keywords: GPCR; homology modeling; olfactory receptor; protein structures; receptors