title: The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas.
abstract: This study deals with the monitoring of plasmatic levels of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by high-performance liquid chromatography (HPLC) after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients suffering from ovarian and endometrial carcinomas has demonstrated elevated levels of malondialdehyde (10.1 +/- 1.1 microM), compared with the control group (7.5 +/- 2.7 microM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content. This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery.
authors.affiliation: Charles University in Prague, Third Faculty of Medicine, Department of Biochemistry, Cell and Molecular Biology, Prague Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Matejcková
authors.forename: M
authors.initials: M
authors.lastname: Samec
authors.forename: E
authors.initials: E
authors.lastname: Samcová
authors.forename: R
authors.initials: R
authors.lastname: Rokyta
authors.forename: P
authors.initials: P
authors.lastname: Tůma
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D016889:Endometrial Neoplasms / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000601:surgery*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde