title: Pancreatic glucagonoma metastasising to the right ovary five years after initial surgery: a case report.
abstract: BACKGROUND
  Glucagonomas of the pancreas are neuroendocrine tumours (NETs) that arise from well-differentiated neuroendocrine cells within the pancreatic islets. They are considered to be aggressive NETs and often have metastases at initial presentation. In contrast localised glucagonoma without metastatic spread may have prolonged disease free survival with radical resectional surgery.
  
  
  METHODS
  The authors present a case of a glucagonoma that initially presented with classical necrolytic migratory erythema and a large solitary mass in the body and tail of the pancreas that was surgically resected. Five years after surgery the patient presented with increased serum glucagon levels and a mass in the right ovary. Pathology of the resected ovary after oophorectomy identified this as an isolated metastatic glucagonoma.
  
  
  CONCLUSIONS
  Glucagonoma is a rare pancreatic NET that has significant malignant potential. This is the first case of a pancreatic glucagonoma metastasising to the ovary 5 years after radical distal pancreatosplenectomy.
authors.affiliation: General Surgery, Ninewells Hospital and Medical School. Dundee, Scotland, United Kingdom. davidwatt1@nhs.net.
authors.forename: David Graham
authors.initials: DG
authors.lastname: Watt
authors.forename: Sanjay
authors.initials: S
authors.lastname: Pandanaboyana
authors.forename: Charles Simon
authors.initials: CS
authors.lastname: Herrington
authors.forename: Iain S
authors.initials: IS
authors.lastname: Tait
mesh_terms: D005260:Female; D005935:Glucagonoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013997:Time Factors