title: Synthetic organic compounds with potential for bacterial biofilm inhibition, a path for the identification of compounds interfering with quorum sensing.
abstract: New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation as well as their control system, the quorum-sensing (QS) system, a mechanism of communication used to co-ordinate bacterial activities. Here we describe the evaluation of synthetic organic compounds as bacterial biofilm inhibitors against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. This approach has successfully allowed the identification of five compounds (GEt, GHex, GOctad, G19 and C33) active not only against bacterial biofilms but also displaying potential to be used as antagonists and/or inhibitors of bacterial QS.
authors.affiliation: Laboratório de Antibióticos, MIP, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil; Departamento de Odontologia, CEPID, CCS, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil. Electronic address: pimenta@u-cergy.fr.
authors.forename: Andréa
authors.initials: A
authors.lastname: de Lima Pimenta
authors.forename: Louise Domeneghini
authors.initials: LD
authors.lastname: Chiaradia-Delatorre
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mascarello
authors.forename: Karen Andrinéia
authors.initials: KA
authors.lastname: de Oliveira
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Leal
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Cláudia Beatriz Nedel Mendes
authors.initials: CB
authors.lastname: de Aguiar
authors.forename: Carla Inês
authors.initials: CI
authors.lastname: Tasca
authors.forename: Ricado José
authors.initials: RJ
authors.lastname: Nunes
authors.forename: Artur
authors.initials: A
authors.lastname: Smânia
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D053038:Quorum Sensing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antimicrobial therapy; Biofilm; Biofilm inhibitors; Quorum sensing; Synthetic compounds