title: Dendritic cell interactions with lymphatic endothelium.
abstract: Afferent lymphatic vessels fulfill essential immune functions by transporting leukocytes and lymph-borne antigen to draining lymph nodes (dLNs). An important cell type migrating through lymphatic vessels are dendritic cells (DCs). DCs reside in peripheral tissues like the skin, where they take up antigen and transport it via the lymphatic vascular network to dLNs for subsequent presentation to T cells. As such, DCs play a key role in the induction of adaptive immune responses during infection and vaccination, but also for the maintenance of tolerance. Although the migratory pattern of DCs has been known for long time, interactions between DCs and lymphatic vessels are only now starting to be unraveled at the cellular level. In particular, new tools for visualizing lymphatic vessels in combination with time-lapse microscopy have recently generated valuable insights into the process of DC migration to dLNs. In this review we summarize and discuss current approaches for visualizing DCs and lymphatic vessels in tissues for imaging applications. Furthermore, we review the current state of knowledge about DC migration towards, into and within lymphatic vessels, particularly focusing on the cellular interactions that take place between DCs and the lymphatic endothelium.
authors.affiliation: Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology , ETH Zurich, Switzerland .
authors.forename: Erica
authors.initials: E
authors.lastname: Russo
authors.forename: Maximilian
authors.initials: M
authors.lastname: Nitschké
authors.forename: Cornelia
authors.initials: C
authors.lastname: Halin
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism*; D004729:Endothelium, Lymphatic / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism*; D042601:Lymphatic Vessels / Q000378:metabolism*; D018613:Microscopy, Confocal; D059008:Time-Lapse Imaging
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