title: Translational control of gene expression in the gonadotrope.
abstract: The study of gene expression in gonadotropes has largely focused on the variety of mechanisms regulating transcription of the gonadotropin genes and ancillary factors that contribute to the overall phenotype and function of these cells in reproduction. However, there are aspects of the response to GNRH signaling that are not readily explained by changes at the level of transcription. As our understanding of regulation at the level of mRNA translation has increased, it has become evident that GNRH receptor signaling engages multiple aspects of translational regulation. This includes activation of cap-dependent translation initiation, translational pausing caused by the unfolded protein response and RNA binding protein interaction. Gonadotropin mRNAs and the mRNAs of other factors that control the transcriptional and signaling responses to GNRH have been identified as targets of regulation at the level of translation. In this review we examine the impact of translational control of the expression of gonadotropin genes and other genes relevant to GNRH-mediated control of gonadotrope function.
authors.affiliation: Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
authors.forename: Taeshin
authors.initials: T
authors.lastname: Kim
authors.affiliation: Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, United States.
authors.forename: Minh-Ha T
authors.initials: MH
authors.lastname: Do
authors.affiliation: Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: mlawson@ucsd.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lawson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D052681:Gonadotrophs / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D010442:Peptide Chain Initiation, Translational / Q000502:physiology*; D011966:Receptors, LHRH / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: D011966:Receptors, LHRH
keywords: Follicle-stimulating hormone; Gonadotropins; Luteinizing hormone; Pituitary; Translation; Unfolded-protein response
references.citation: J Clin Endocrinol Metab. 2007 Jul;92(7):2468-73
references.pmid: 17440019
references.citation: Science. 2011 Sep 30;333(6051):1891-4
references.pmid: 21852455
references.citation: Cell Cycle. 2012 Mar 15;11(6):1118-22
references.pmid: 22370484
references.citation: Biochem Soc Trans. 2002 Nov;30(Pt 6):952-8
references.pmid: 12440953
references.citation: Curr Opin Genet Dev. 1999 Feb;9(1):49-54
references.pmid: 10072357
references.citation: Mol Cell Biol. 1998 Dec;18(12):7499-509
references.pmid: 9819435
references.citation: Nat Rev Genet. 2007 Sep;8(9):711-23
references.pmid: 17680008
references.citation: Nature. 2009 Feb 5;457(7230):687-93
references.pmid: 19079236
references.citation: Neurochem Res. 2002 Oct;27(10):957-80
references.pmid: 12462398
references.citation: Adv Exp Med Biol. 2010;664:115-21
references.pmid: 20238009
references.citation: Mol Cell Endocrinol. 1992 Oct;88(1-3):143-51
references.pmid: 1281125
references.citation: Virus Res. 2006 Jul;119(1):76-88
references.pmid: 16303201
references.citation: EMBO J. 1998 Jun 15;17(12):3461-70
references.pmid: 9628881
references.citation: Eur J Biochem. 2002 Nov;269(22):5350-9
references.pmid: 12423333
references.citation: J Biol Chem. 2008 Sep 12;283(37):25227-25237
references.pmid: 18614538
references.citation: Endocrinology. 1994 Jun;134(6):2475-81
references.pmid: 7515001
references.citation: Neurosignals. 2006-2007;15(5):249-58
references.pmid: 17496426
references.citation: Endocrinology. 2002 Sep;143(9):3243-9
references.pmid: 12193535
references.citation: Endocrinology. 1992 Jan;130(1):415-20
references.pmid: 1345779
references.citation: Mol Cell Biol. 2008 Jul;28(14):4562-75
references.pmid: 18490444
references.citation: Annu Rev Cell Dev Biol. 1998;14:399-458
references.pmid: 9891789
references.citation: J Biol Chem. 1996 Apr 12;271(15):8983-90
references.pmid: 8621544
references.citation: Mol Cell. 2000 Dec;6(6):1355-64
references.pmid: 11163209
references.citation: Nat Cell Biol. 2013 May;15(5):481-90
references.pmid: 23624402
references.citation: Mol Endocrinol. 1993 Dec;7(12):1625-33
references.pmid: 8145768
references.citation: Diabetologia. 2010 Jun;53(6):1120-30
references.pmid: 20349222
references.citation: Trends Immunol. 2004 Jan;25(1):17-24
references.pmid: 14698280
references.citation: Mol Cell Biol. 2003 Nov;23(21):7448-59
references.pmid: 14559994
references.citation: Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):42-57
references.pmid: 21278925
references.citation: Endocrinology. 2001 Jan;142(1):139-46
references.pmid: 11145576
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10738-43
references.pmid: 18658239
references.citation: J Biol Chem. 2010 Oct 22;285(43):33165-33174
references.pmid: 20732869
references.citation: Mol Endocrinol. 2006 Nov;20(11):2909-30
references.pmid: 16772531
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74
references.pmid: 15277680
references.citation: Endocrinology. 1995 Mar;136(3):1128-36
references.pmid: 7867566
references.citation: Mol Cell Biol. 2003 Feb;23(4):1292-303
references.pmid: 12556489
references.citation: Mol Endocrinol. 2009 Jan;23(1):100-12
references.pmid: 18974261
references.citation: J Mol Endocrinol. 2013 Feb 15;50(2):151-66
references.pmid: 23256993
references.citation: J Clin Endocrinol Metab. 1997 Nov;82(11):3728-33
references.pmid: 9360532
references.citation: J Virol. 1988 Aug;62(8):2636-43
references.pmid: 2839690
references.citation: Cell Rep. 2013 Apr 25;3(4):1279-92
references.pmid: 23583182
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D125-30
references.pmid: 16381829
references.citation: Biol Reprod. 2004 Oct;71(4):1158-66
references.pmid: 15189830
references.citation: BMC Bioinformatics. 2008 May 08;9:232
references.pmid: 18466625
references.citation: Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4622-7
references.pmid: 23471998
references.citation: J Cell Biol. 2006 Feb 13;172(4):565-75
references.pmid: 16461360
references.citation: Gene. 2004 May 12;332:1-11
references.pmid: 15145049
references.citation: Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16113-8
references.pmid: 20798350
references.citation: Mol Endocrinol. 2000 Nov;14(11):1811-9
references.pmid: 11075814
references.citation: Virus Res. 2007 Mar;124(1-2):44-9
references.pmid: 17092596
references.citation: Cell Signal. 2008 Dec;20(12):2165-73
references.pmid: 18585896
references.citation: Nucleic Acids Res. 2008 May;36(8):2476-88
references.pmid: 18310103
references.citation: FASEB J. 1989 Oct;3(12):2360-70
references.pmid: 2676679
references.citation: Endocrinology. 1972 Nov;91(5):1253-8
references.pmid: 4672428
references.citation: J Biol Chem. 2009 Aug 7;284(32):21241-8
references.pmid: 19509279
references.citation: Gene. 2003 Apr 10;308:67-77
references.pmid: 12711391
references.citation: Science. 2011 Nov 25;334(6059):1081-6
references.pmid: 22116877
references.citation: Mol Cell Biol. 2002 Jun;22(11):3864-74
references.pmid: 11997520
references.citation: Mol Cell Biol. 2004 Feb;24(3):1365-77
references.pmid: 14729979
references.citation: J Biol Chem. 2004 Oct 8;279(41):43046-51
references.pmid: 15299016
references.citation: J Clin Endocrinol Metab. 2007 Apr;92(4):1347-52
references.pmid: 17264175
references.citation: J Clin Endocrinol Metab. 2006 Apr;91(4):1309-16
references.pmid: 16434454
references.citation: Genetica. 2013 Sep;141(7-9):311-8
references.pmid: 23963880
references.citation: Cell. 2008 Sep 19;134(6):1042-54
references.pmid: 18805096
references.citation: Biol Reprod. 2012 Feb 29;86(2):53
references.pmid: 22053098
references.citation: Genome Biol Evol. 2012;4(10):1046-53
references.pmid: 23034215
references.citation: Endocrinology. 2010 Oct;151(10):4882-93
references.pmid: 20685880
references.citation: EMBO J. 2003 Mar 3;22(5):1180-7
references.pmid: 12606582
references.citation: Cell Death Differ. 2006 Mar;13(3):374-84
references.pmid: 16397578
references.citation: J Clin Invest. 2005 Feb;115(2):268-81
references.pmid: 15690081
references.citation: Trends Biochem Sci. 2013 Jan;38(1):47-55
references.pmid: 23218750
references.citation: Nucleic Acids Res. 2010 Jan;38(1):225-38
references.pmid: 19850717
references.citation: Science. 2011 Sep 30;333(6051):1830-1
references.pmid: 21960615
references.citation: J Cell Biol. 2001 May 28;153(5):1011-22
references.pmid: 11381086
references.citation: Endocrinology. 1974 Jul;95(1):323-5
references.pmid: 4134210
references.citation: Eur J Biochem. 1998 May 1;253(3):531-44
references.pmid: 9654048
references.citation: FEBS Lett. 2012 Dec 14;586(24):4319-25
references.pmid: 23127556
references.citation: Science. 2005 Dec 2;310(5753):1452-6
references.pmid: 16322447
references.citation: Mol Cell. 2001 Jun;7(6):1165-76
references.pmid: 11430820
references.citation: Mol Endocrinol. 1990 Oct;4(10):1444-50
references.pmid: 2126596
references.citation: J Biol Chem. 1993 Feb 15;268(5):3017-20
references.pmid: 8428975
references.citation: Biol Res. 2005;38(2-3):121-46
references.pmid: 16238092
references.citation: Diabetes Obes Metab. 2010 Oct;12 Suppl 2:48-57
references.pmid: 21029300
references.citation: Atherosclerosis. 2013 Jan;226(1):95-101
references.pmid: 23116706
references.citation: Mol Cell Biol. 2004 Aug;24(15):6539-49
references.pmid: 15254222
references.citation: Endocrinology. 1975 Mar;96(3):571-5
references.pmid: 1090435
references.citation: Biochem Soc Trans. 2006 Apr;34(Pt 2):213-6
references.pmid: 16545079
references.citation: Nature. 2001 Jul 19;412(6844):300-7
references.pmid: 11460154
references.citation: Proc Natl Acad Sci U S A. 2009 May 19;106(20):8326-31
references.pmid: 19416856
references.citation: J Biol Chem. 2004 Nov 19;279(47):49298-306
references.pmid: 15371446
references.citation: Genes Dev. 2004 Mar 15;18(6):660-72
references.pmid: 15075293
references.citation: Mol Endocrinol. 2007 May;21(5):1175-91
references.pmid: 17299135
references.citation: Endocrinology. 2013 Sep;154(9):3228-39
references.pmid: 23736291
references.citation: Endocrinology. 2001 Aug;142(8):3435-42
references.pmid: 11459788
references.citation: FEBS Lett. 2008 Jun 18;582(14):1977-86
references.pmid: 18342629
references.citation: Mol Cell. 2001 Jun;7(6):1153-63
references.pmid: 11430819
references.citation: Mol Endocrinol. 2004 May;18(5):1301-12
references.pmid: 14752057
references.citation: Nature. 1991 Sep 5;353(6339):90-4
references.pmid: 1652694
references.citation: Trends Endocrinol Metab. 2011 Jul;22(7):266-74
references.pmid: 21458293