title: Association of endothelin-converting enzyme-1b C-338A polymorphism with increased risk of ischemic stroke in Chinese Han population.
abstract: Endothelin-converting enzyme-1b (ECE-1b) C-338A is a polymorphism located in ECE-1 gene promoter, which has been reported to correlate with the risk of carotid atherosclerosis. We conducted a hospital-based case-control study of 309 patients with ischemic stroke and 309 controls matched on age and gender. The frequencies of ECE-1b-338 CC, CA, and AA genotypes in cases (45.0, 40.4, and 14.6 %) were significantly different from those of controls (53.1, 39.1, and 7.8 %, χ(2) = 8.519, P = 0.014), respectively. Compared with C carriers, A alleles showed correlation with a 42 % increased risk of ischemic stroke (adjusted odds ratio (OR) = 1.42, 95 % CI = 1.11-1.81). After adjustment for potential risk factors, the AA genotype still kept positive correlation with ischemic stroke (OR = 1.78; 95 % CI = 1.06-3.54). In stratified analyses, the significant association of the A allele with ischemic stroke was observed in female subjects (adjusted OR = 1.64, 95 % CI = 1.17-2.89) and the subjects with age ≥ 64 years old (adjusted OR = 2.09, 95 % CI = 1.38-3.23). The present study suggested that the C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.
authors.affiliation: Graduate School, Bengbu Medical College, Bengbu, Anhui, 233004, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Cui
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: Mingming
authors.initials: M
authors.lastname: Yu
authors.forename: Zegang
authors.initials: Z
authors.lastname: Ying
authors.forename: Shiming
authors.initials: S
authors.lastname: Zhou
authors.forename: Huadong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D016282:Aspartic Acid Endopeptidases / Q000235:genetics*; D002545:Brain Ischemia / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D000072396:Endothelin-Converting Enzymes; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D020521:Stroke / Q000175:diagnosis / Q000235:genetics*
chemical_list: D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; C000606923:ECE1 protein, human; D000072396:Endothelin-Converting Enzymes
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