title: Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines.
abstract: Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK. d.j.fox@warwick.ac.uk.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Perryman
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Harris
authors.forename: Jade L
authors.initials: JL
authors.lastname: Foster
authors.forename: Anushka
authors.initials: A
authors.lastname: Joshi
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Clarkson
authors.forename: David J
authors.initials: DJ
authors.lastname: Fox
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002725:Chloroform / Q000737:chemistry*; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines; D007659:Ketones; D012428:Ruthenium; D002725:Chloroform