title: Lactate biosensors: current status and outlook.
abstract: Many research efforts over the last few decades have been devoted to sensing lactate as an important analytical target in clinical care, sport medicine, and food processing. Therefore, research in designing lactate sensors is no longer in its infancy and now is more directed toward viable sensors for direct applications. In this review, we provide an overview of the most immediate and relevant developments toward this end, and we discuss and assess common transduction approaches. Further, we critically describe the pros and cons of current commercial lactate sensors and envision how future sensing design may benefit from emerging new technologies.
authors.affiliation: Laboratory of Organic Materials and Interfaces, Department of Chemical Engineering, Delft University of Technology, Julianalaan 136, 2628, BL, Delft, The Netherlands, l.rassaei@tudelft.nl.
authors.forename: Liza
authors.initials: L
authors.lastname: Rassaei
authors.forename: Wouter
authors.initials: W
authors.lastname: Olthuis
authors.forename: Seiya
authors.initials: S
authors.lastname: Tsujimura
authors.forename: Ernst J R
authors.initials: EJ
authors.lastname: Sudhölter
authors.forename: Albert
authors.initials: A
authors.lastname: van den Berg
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D001826:Body Fluids / Q000737:chemistry; D055664:Electrochemical Techniques; D005504:Food Analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood*; D008163:Luminescent Measurements; D008839:Microelectrodes; D006899:Mixed Function Oxygenases / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013178:Sports Medicine
chemical_list: D019344:Lactic Acid; D006899:Mixed Function Oxygenases; D007770:L-Lactate Dehydrogenase; C021497:lactate 2-monooxygenase