title: SDOCT thickness measurements of various retinal layers in patients with autosomal dominant optic atrophy due to OPA1 mutations.
abstract: OBJECTIVE
  To specify thickness values of various retinal layers on macular spectral domain Optical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls.
  
  
  METHODS
  SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5-8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear layer/photoreceptor layers (ONL+PL).
  
  
  RESULTS
  ADOA patients showed statistically significant lower retinal thickness values than controls (P < 0.01). RNFL (P < 0.001) and GCL thicknesses (P < 0.001) were significantly lower in ADOA patients. There was no difference in IPL+INL+OPL and in ONL+PL thickness.
  
  
  CONCLUSIONS
  Manual subanalysis of macular SDOCT volume scans allowed detailed subanalysis of various retinal layers. Not only RNFL but also GCL thicknesses are reduced in the macular area of ADOA patients whereas subjacent layers are not involved. Together with clinical findings, macular SDOCT helps to identify patients with suspicion for hereditary optic neuropathy before genetic analysis confirms the diagnosis.
authors.affiliation: Department of Ophthalmology, University Hospital of Cologne, 50924 Cologne, Germany.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Schild
authors.forename: Tina
authors.initials: T
authors.lastname: Ristau
authors.forename: Julia
authors.initials: J
authors.lastname: Fricke
authors.forename: Antje
authors.initials: A
authors.lastname: Neugebauer
authors.forename: Bernd
authors.initials: B
authors.lastname: Kirchhof
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
authors.forename: Sandra
authors.initials: S
authors.lastname: Liakopoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D020558:GTP Phosphohydrolases / Q000235:genetics*; D006801:Humans; D008297:Male; D029241:Optic Atrophy, Autosomal Dominant / Q000235:genetics* / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D012160:Retina / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D041623:Tomography, Optical Coherence
chemical_list: D020558:GTP Phosphohydrolases; C415198:OPA1 protein, human
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