title: Central nervous system cancers.
abstract: Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma harboring the 1p/19q codeletion. For metastatic disease, increasing evidence supports the efficacy of stereotactic radiosurgery in treating patients with multiple metastatic lesions but low overall tumor volume. These guidelines provide recommendations on the diagnosis and management of this group of diseases based on clinical evidence and panel consensus. This version includes expert advice on the management of low-grade infiltrative astrocytomas, oligodendrogliomas, anaplastic gliomas, glioblastomas, medulloblastomas, supratentorial primitive neuroectodermal tumors, and brain metastases. The full online version, available at NCCN. org, contains recommendations on additional subtypes.
authors.forename: Louis Burt
authors.initials: LB
authors.lastname: Nabors
authors.forename: Mario
authors.initials: M
authors.lastname: Ammirati
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Bierman
authors.forename: Henry
authors.initials: H
authors.lastname: Brem
authors.forename: Nicholas
authors.initials: N
authors.lastname: Butowski
authors.forename: Marc C
authors.initials: MC
authors.lastname: Chamberlain
authors.forename: Lisa M
authors.initials: LM
authors.lastname: DeAngelis
authors.forename: Robert A
authors.initials: RA
authors.lastname: Fenstermaker
authors.forename: Allan
authors.initials: A
authors.lastname: Friedman
authors.forename: Mark R
authors.initials: MR
authors.lastname: Gilbert
authors.forename: Deneen
authors.initials: D
authors.lastname: Hesser
authors.forename: Matthias
authors.initials: M
authors.lastname: Holdhoff
authors.forename: Larry
authors.initials: L
authors.lastname: Junck
authors.forename: Ronald
authors.initials: R
authors.lastname: Lawson
authors.forename: Jay S
authors.initials: JS
authors.lastname: Loeffler
authors.forename: Moshe H
authors.initials: MH
authors.lastname: Maor
authors.forename: Paul L
authors.initials: PL
authors.lastname: Moots
authors.forename: Tara
authors.initials: T
authors.lastname: Morrison
authors.forename: Maciej M
authors.initials: MM
authors.lastname: Mrugala
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Newton
authors.forename: Jana
authors.initials: J
authors.lastname: Portnow
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Raizer
authors.forename: Lawrence
authors.initials: L
authors.lastname: Recht
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Shrieve
authors.forename: Allen K
authors.initials: AK
authors.lastname: Sills
authors.forename: David
authors.initials: D
authors.lastname: Tran
authors.forename: Nam
authors.initials: N
authors.lastname: Tran
authors.forename: Frank D
authors.initials: FD
authors.lastname: Vrionis
authors.forename: Patrick Y
authors.initials: PY
authors.lastname: Wen
authors.forename: Nicole
authors.initials: N
authors.lastname: McMillian
authors.forename: Maria
authors.initials: M
authors.lastname: Ho
mesh_terms: D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans
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