title: Anti-inflammatory and anti-atherogenic role of BMP receptor II in atherosclerosis.
abstract: Evaluation of: Kim CW, Song H, Kumar S et al. Anti-inflammatory and anti-atherogenic role of BMP receptor II in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33, 1350-1359 (2013). Increased expression of BMPs in atherosclerosis suggested that the knockdown of the receptor mediating BMP action would prevent endothelial inflammation and atherosclerosis. Based on this hypothesis, Kim et al. performed a series of experiments in which the effect of BMP receptor type II (BMPRII) knockout was tested in in vitro and in vivo models of atherogenesis. Unexpectedly, they found that the loss of BMPRII induces endothelial inflammation and atherosclerosis. Knockdown of BMPRII in endothelial cells induced monocyte adhesion through the expression of ICAM-1 and VCAM-1. The loss of BMPRII induced endothelial inflammation and atherosclerosis in apoE-deficient mice. Besides, BMPRII expression was gradually lost over the course of atherosclerosis progression in human coronary arteries.
authors.affiliation: Institute of Medical & Clinical Biochemistry, Faculty of Medicine, University of Belgrade, Serbia; Pasterova 2, 11000 Belgrade, Serbia. tatjanasimic@med.bg.ac.rs.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Simic
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D052004:Bone Morphogenetic Protein Receptors / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D052004:Bone Morphogenetic Protein Receptors