title: Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011.
abstract: Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004-2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010-2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation.
authors.forename: Nicksy
authors.initials: N
authors.lastname: Gumede
authors.forename: Olivia
authors.initials: O
authors.lastname: Lentsoane
authors.forename: Cara C
authors.initials: CC
authors.lastname: Burns
authors.forename: Mark
authors.initials: M
authors.lastname: Pallansch
authors.forename: Esther
authors.initials: E
authors.lastname: de Gourville
authors.forename: Riziki
authors.initials: R
authors.lastname: Yogolelo
authors.forename: Jean Jacques
authors.initials: JJ
authors.lastname: Muyembe-Tamfum
authors.forename: Adrian
authors.initials: A
authors.lastname: Puren
authors.forename: Barry D
authors.initials: BD
authors.lastname: Schoub
authors.forename: Marietjie
authors.initials: M
authors.lastname: Venter
mesh_terms: D000208:Acute Disease; D036022:Capsid Proteins / Q000235:genetics; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D015023:Democratic Republic of the Congo; D005243:Feces / Q000821:virology; D006801:Humans; D015994:Incidence; D008969:Molecular Sequence Data; D009123:Muscle Hypotonia / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D010243:Paralysis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D010802:Phylogeny; D011051:Poliomyelitis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D017955:Poliovirus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D011055:Poliovirus Vaccine, Oral / Q000235:genetics* / Q000276:immunology; D017422:Sequence Analysis, DNA; D014611:Vaccination
chemical_list: D036022:Capsid Proteins; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus
keywords: DRC; Democratic Republic of Congo; circulating VDPV; poliovirus; vaccine-derived poliovirus; viruses
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