title: Stepping down in asthma.
abstract: Beta-2-agonists continue to find a dominant role in all the current guidelines on the management of chronic persistent bronchial asthma. However, the safety of the drugs remains doubtful. Thus, there is a case for review of the "Step up-Step down" approach in the management of chronic persistent bronchial asthma. Based on the currently available experimental and clinical data on bronchial asthma, the authors are of the opinion that chronic persistent bronchial asthma is best managed by a modified "Step I-Step II" approach.
authors.affiliation: Department of TB and Respiratory Diseases, SMS Medical College, Jaipur (Rajasthan), India. Guptapr_dr@hotmail.com
authors.forename: P R
authors.initials: PR
authors.lastname: Gupta
authors.forename: Shubhra
authors.initials: S
authors.lastname: Jain
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D058666:Adrenergic beta-2 Receptor Agonists / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D006801:Humans
chemical_list: D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D018927:Anti-Asthmatic Agents