title: Sensorimotor and psychosocial determinants of 3-year incident mobility disability in middle-aged and older adults.
abstract: OBJECTIVE
  to identify sensorimotor and psychosocial determinants of 3-year incident mobility disability.
  
  
  METHODS
  prospective.
  
  
  METHODS
  population-based sample of community-dwelling older persons.
  
  
  METHODS
  community-living middle-aged and older persons (age: 50-85 years) without baseline mobility disability (n = 622).
  
  
  METHODS
  mobility disability, defined as self-reported inability to walk a quarter mile without resting or inability to walk up a flight of stairs unsupported, was ascertained at baseline and 3-year follow-up. Potential baseline determinant characteristics included demographics, education, social support, financial condition, knee extensor strength, visual contrast sensitivity, cognition, depression, presence of chronic conditions and history of falls.
  
  
  RESULTS
  a total of 13.5% participant reported 3-year incident mobility disability. Age ≥75 years, female sex, knee extensor strength in the lowest quartile, visual contrast sensitivity <1.7 on the Pelli-Robson chart or significant depressive symptoms (CESD score >16) were independent determinants of 3-year incident mobility disability (ORs 1.84-16.51).
  
  
  CONCLUSIONS
  low visual contrast sensitivity, poor knee extensor strength and significant depressive symptoms are independent determinants of future onset of mobility disability.
authors.affiliation: School of Rehabilitation Therapy, Queen's University, Kingston, ON, Canada.
authors.forename: Nandini
authors.initials: N
authors.lastname: Deshpande
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Metter
authors.forename: Jack
authors.initials: J
authors.lastname: Guralnik
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D003071:Cognition; D015350:Contrast Sensitivity; D051341:Dependent Ambulation; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D004185:Disability Evaluation; D005260:Female; D005382:Financing, Personal; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007717:Knee; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000503:physiopathology*; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012944:Social Support; D013997:Time Factors; D016138:Walking
keywords: depression; disability; mobility; muscle strength; older people; vision
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