title: Photodynamic therapy for high-grade dysplasia of bile duct via a choledochoscope.
abstract: When a distal common bile duct neoplasm is at the stage of carcinoma in situ or high-grade dysplasia, it is difficult for the surgeon to decide whether to perform pancreaticoduodenectomy. Here we describe a patient with a progressive dysplastic lesion in the common bile duct, which developed from moderate-high to high-grade dysplasia in approximately 2 mo. The patient refused major surgery. Therefore, endoscopic-assisted photodynamic therapy was performed. The result at follow-up using a trans-T-tube choledochoscope showed that the lesion was completely necrotic. This report is the first to describe the successful treatment of high-grade dysplasia of the distal bile duct using photodynamic therapy via a choledochoscope.
authors.affiliation: Jiang-Jiao Zhou, Li Xiong, Qing-Long Li, Ying Gu, Yu Wen, Xiao-Feng Deng, Xiong-Ying Miao, Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Jiang-Jiao
authors.initials: JJ
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Xiong
authors.forename: Qing-Long
authors.initials: QL
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wen
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Deng
authors.forename: Xiong-Ying
authors.initials: XY
authors.lastname: Miao
mesh_terms: D003138:Common Bile Duct Neoplasms / Q000188:drug therapy*; D006415:Hematoporphyrins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use
chemical_list: D006415:Hematoporphyrins; D017319:Photosensitizing Agents
keywords: Choledochoscope; Common bile duct; High-grade dysplasia; Photodynamic therapy
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