title: Mitochondrial sirtuins as therapeutic targets for age-related disorders.
abstract: Sirtuins are a class of histone deacetylases that have a wide range of regulatory roles in the cell. Three sirtuins, SIRT3 to SIRT5, localize to and function within the mitochondria. Mitochondrial dysfunction is thought to be the underlying mechanism of several age-related diseases, such as metabolic syndrome, cancer, and neurodegeneration. This review examines current evidence that mitochondrial sirtuins are involved in regulating mitochondrial function and pathogenesis.
authors.affiliation: Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Shih
authors.forename: Gizem
authors.initials: G
authors.lastname: Donmez
keywords: aging; cancer; metabolic syndrome; mitochondria; neurodegeneration; sirtuins; therapeutic targets
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