title: [Feasibility of using intravascular loopless monopole antenna to image atherosclerotic plaque in a porcine model with 3.0 T magnetic resonance imaging].
abstract: OBJECTIVE
  To investigate the feasibility of using intravascular loopless monopole antenna (ILMA) to image atherosclerosis plaque in a porcine model with 3.0T magnetic resonance imaging (MRI).
  
  
  METHODS
  Atherosclerosis model was established by feeding high fat diet combined with balloon catheter injury to the endothelium in 6 pigs. After 3 months, animals underwent MRI and ILMA examination. The ILMA was invasively inserted to the distal part of abdominal vein and bilateral common iliac veins. MR sequences including T1 weighted imaging (T1WI), T2WI were obtained. MR image data were transferred to post-processing station. Luminal border and external elastic membrane of the vessel were reconstructed based on the MR images. After co-register these images, vessel area, lumen area, vessel wall area and plaque burden in the same lesions imaged by different modality were calculated and compared. Finally, all animals were scarified and hematoxylin eosin (HE) staining was performed in the targeted vessels. Diagnostic accuracy of MR in delineating vessel wall and detecting plaque were analyzed and calculated by comparing with pathological results.
  
  
  RESULTS
  The atherosclerotic model was successfully established in all 6 pigs. Good agreement of delineating vessel area, lumen area vessel, wall area and plaque burden were found between MRI and pathology with r value of 0.98, 0.95, and 0.96, respectively (P < 0.001). Compared with pathological findings, the plaque component in corresponding area imaged by MR was as follows: sensitivity and specificity of detecting lipid plaque were 77% and 69%, kappa value was 0.75 ± 0.19 (P < 0.01); sensitivity and specificity on detecting fibrotic plaque were 78% and 73%, Κ value was 0.78 ± 0.18 (P < 0.01). The sensitivity and specificity of detecting calcified plaque were 100%. ILMA results showed that the average lumen area was 49.72 mm(2), average vessel area was 124.08 mm(2), and the average vessel wall area was 74.37 mm(2), ILMA slightly overestimated these indexes as compared with pathological results.
  
  
  CONCLUSIONS
  The results showed that ILMA could be used to image deepened artery and atherosclerotic plaque. Detected plaque size, vessel area, lumen area vessel, wall area, and plaque burden were comparable to pathological findings. It may thus provide an alternative method for detecting atherosclerotic plaque in future research work.
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital,Capital Medical University, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiao-hai
authors.initials: XH
authors.lastname: Ma
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Shang
authors.forename: Hong-yang
authors.initials: HY
authors.lastname: Yuan
authors.forename: Jue
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhao-qi
authors.initials: ZQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018810:Magnetic Resonance Angiography / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000175:diagnosis*; D013552:Swine; D013556:Swine, Miniature