title: The repertoire of MHC class I genes in the common marmoset: evidence for functional plasticity.
abstract: In humans, the classical antigen presentation function of major histocompatibility complex (MHC) class I molecules is controlled by the human leukocyte antigen HLA -A, HLA-B and HLA-C loci. A similar observation has been made for great apes and Old World monkey species. In contrast, a New World monkey species such as the cotton-top tamarin (Saguinus oedipus) appears to employ the G locus for its classical antigen presentation function. At present, little is known about the classical MHC class I repertoire of the common marmoset (Callithrix jacchus), another New World monkey that is widely used in biomedical research. In the present population study, no evidence has been found for abundant transcription of classical I class genes. However, in each common marmoset, four to seven different G-like alleles were detected, suggesting that the ancestral locus has been subject to expansion. Segregation studies provided evidence for at least two G-like genes present per haplotype, which are transcribed by a variety of cell types. The alleles of these Caja-G genes cluster in separate lineages, suggesting that the loci diversified considerably after duplication. Phylogenetic analyses of the introns confirm that the Caja-G loci cluster in the vicinity of HLA-G, indicating that both genes shared an ancestor. In contrast to HLA-G, Caja-G shows considerable polymorphism at the peptide-binding sites. This observation, together with the lack of detectable transcripts of A and B-like genes, indicates that Caja-G genes have taken over the function of classical class I genes. These data highlight the extreme plasticity of the MHC class I gene system.
authors.affiliation: Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ, Rijswijk, The Netherlands.
authors.forename: Marit K
authors.initials: MK
authors.lastname: van der Wiel
authors.forename: Nel
authors.initials: N
authors.lastname: Otting
authors.forename: Natasja G
authors.initials: NG
authors.lastname: de Groot
authors.forename: Gaby G M
authors.initials: GG
authors.lastname: Doxiadis
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Bontrop
mesh_terms: D000483:Alleles; D000818:Animals; D002144:Callithrix / Q000235:genetics* / Q000276:immunology; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D059951:HLA-G Antigens
references.citation: J Immunol. 1996 Sep 15;157(6):2403-9
references.pmid: 8805639
references.citation: J Reprod Immunol. 1999 Jul;43(2):111-25
references.pmid: 10479048
references.citation: Nature. 1990 Jul 5;346(6279):60-3
references.pmid: 2114550
references.citation: Placenta. 2012 Feb;33 Suppl:S71-80
references.pmid: 22177321
references.citation: Exp Toxicol Pathol. 2002 Feb;53(6):413-20
references.pmid: 11930901
references.citation: Fertil Steril. 2011 Mar 15;95(4):1428-34
references.pmid: 21122840
references.citation: J Immunol. 1997 Oct 1;159(7):3311-21
references.pmid: 9317129
references.citation: Immunogenetics. 1996;43(6):327-36
references.pmid: 8606053
references.citation: Tissue Antigens. 2007 Apr;69 Suppl 1:72-5
references.pmid: 17445171
references.citation: Immunol Today. 2000 Jun;21(6):290-7
references.pmid: 10825741
references.citation: Genome Res. 2004 Aug;14(8):1501-15
references.pmid: 15289473
references.citation: Mol Biol Evol. 2007 Aug;24(8):1596-9
references.pmid: 17488738
references.citation: J Immunol. 1998 Jan 1;160(1):189-96
references.pmid: 9551971
references.citation: Immunogenetics. 2011 Aug;63(8):485-99
references.pmid: 21505866
references.citation: Nat Rev Immunol. 2013 Feb;13(2):133-44
references.pmid: 23334245
references.citation: Reproduction. 2012 May;143(5):597-609
references.pmid: 22323619
references.citation: Proc Natl Acad Sci U S A. 1988 Oct;85(20):7714-8
references.pmid: 2902637
references.citation: Eur J Immunol. 2012 Jan;42(1):217-27
references.pmid: 21928277
references.citation: Immunogenetics. 2002 Jun;54(3):164-73
references.pmid: 12073145
references.citation: Immunogenetics. 2010 Jun;62(6):409-18
references.pmid: 20445972
references.citation: J Gen Virol. 1996 Jun;77 ( Pt 6):1173-80
references.pmid: 8683204
references.citation: Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11745-50
references.pmid: 9751736
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14536-41
references.pmid: 9405648
references.citation: Hum Immunol. 2006 Jun;67(6):388-97
references.pmid: 16728259
references.citation: J Neuroimmunol. 2006 Jul;176(1-2):39-50
references.pmid: 16750573
references.citation: Front Immunol. 2012 Dec 24;3:394
references.pmid: 23269923
references.citation: Science. 1996 Apr 5;272(5258):67-74
references.pmid: 8600539
references.citation: Immunogenetics. 2012 Aug;64(8):615-31
references.pmid: 22526602
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1626-31
references.pmid: 15665097
references.citation: Trends Genet. 2012 Dec;28(12):586-91
references.pmid: 23099234
references.citation: J Virol. 2003 Aug;77(16):9029-40
references.pmid: 12885919
references.citation: BMC Immunol. 2011 Jul 15;12:39
references.pmid: 21762519
references.citation: Drug Discov Today. 2010 Dec;15(23-24):985-90
references.pmid: 20732446
references.citation: J Immunol. 1996 Dec 15;157(12):5428-37
references.pmid: 8955191
references.citation: PLoS One. 2012;7(8):e43709
references.pmid: 22952743
references.citation: Mol Biol Evol. 2004 Nov;21(11):2079-91
references.pmid: 15269276
references.citation: Science. 1990 Apr 13;248(4952):220-3
references.pmid: 2326636
references.citation: Immunogenetics. 1991;33(2):79-89
references.pmid: 1840570
references.citation: Acta Biochim Biophys Sin (Shanghai). 2010 Apr;42(4):281-7
references.pmid: 20383467
references.citation: Science. 1962 Oct 26;138(3539):513-5
references.pmid: 17753948
references.citation: Tissue Antigens. 2010 Apr;75(4):291-455
references.pmid: 20356336
references.citation: Acta Neuropathol. 2002 Jan;103(1):48-58
references.pmid: 11837747
references.citation: Semin Immunol. 2008 Dec;20(6):317-20
references.pmid: 18656382
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5864-8
references.pmid: 16581907