title: Enantioselective 1,6-conjugate addition of dialkylzinc reagents to acyclic dienones catalyzed by Cu-DiPPAM complex-extension to asymmetric sequential 1,6/1,4-conjugate addition.
abstract: CC coupling: DiPPAM 1 and BINAP 2 ligands led to divergent behaviors in the asymmetric conjugate addition (ACA) of dialkylzinc reagents to linear aryldienones, which were applied to the development of a highly selective sequential asymmetric 1,6/1,4-ACA process (see scheme; Tf = triflate, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7 (France).
authors.forename: Magaly
authors.initials: M
authors.lastname: Magrez-Chiquet
authors.forename: Marie S T
authors.initials: MS
authors.lastname: Morin
authors.forename: Joanna
authors.initials: J
authors.lastname: Wencel-Delord
authors.forename: Sammy
authors.initials: S
authors.lastname: Drissi Amraoui
authors.forename: Olivier
authors.initials: O
authors.lastname: Baslé
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis
authors.forename: Christophe
authors.initials: C
authors.lastname: Crévisy
authors.forename: Marc
authors.initials: M
authors.lastname: Mauduit
keywords: CC coupling; Michael reaction; asymmetric synthesis; stereoselective catalysis