title: Focal adhesion complex proteins in epidermis and squamous cell carcinoma.
abstract: Focal adhesions (FAs) are large, integrin-containing, multi-protein assemblies spanning the plasma membrane that link the cellular cytoskeleton to surrounding extracellular matrix. They play critical roles in adhesion and cell signaling and are major regulators of epithelial homeostasis, tissue response to injury, and tumorigenesis. Most integrin subunits and their associated FA proteins are expressed in skin, and murine genetic models have provided insight into the functional roles of FAs in normal and neoplastic epidermis. Here, we discuss the roles of these proteins in normal epidermal proliferation, adhesion, wound healing, and cancer. While many downstream signaling mechanisms remain unclear, the critically important roles of FAs are highlighted by the development of therapeutics targeting FAs for human cancer.
authors.affiliation: Department of Dermatology; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Duperret
authors.forename: Todd W
authors.initials: TW
authors.lastname: Ridky
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D022001:Focal Adhesions / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D058990:Molecular Targeted Therapy; D046912:Multiprotein Complexes / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D046912:Multiprotein Complexes
keywords: Extracellular Matrix; Focal Adhesion; Integrin; Skin; Squamous Cell Carcinoma
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