title: γ-Carbonyl quinones: radical strategy for the synthesis of evelynin and its analogues by C-H activation of quinones using cyclopropanols.
abstract: Cyclopropanols, on oxidative ring opening with AgNO3-K2S2O8 in DCM-H2O at room temperature and under open flask conditions, produced β-keto radicals which were successfully added to quinones to furnish γ-carbonyl quinones. This mild method has been applied to the synthesis of cytotoxic natural products, 4,6-dimethoxy-2,5-quinodihydrochalcone and evelynin.
authors.affiliation: School of Chemistry, Bharathidasan University , Tiruchirappalli 620024, India and Syngene International Ltd. , Bangalore 560 099, India.
authors.forename: Andivelu
authors.initials: A
authors.lastname: Ilangovan
authors.forename: Shanmugasundar
authors.initials: S
authors.lastname: Saravanakumar
authors.forename: Subramani
authors.initials: S
authors.lastname: Malayappasamy
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002599:Chalcone / Q000138:chemical synthesis* / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry*; D010084:Oxidation-Reduction; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D004988:Ethers, Cyclic; D011809:Quinones; C043657:cyclopropanol; D002599:Chalcone