title: Cyclical caspofungin for chronic pulmonary aspergillosis in sarcoidosis.
abstract: In sarcoidosis, chronic pulmonary aspergillosis (CPA) may be associated with significant morbidity, and treatment failure rates are often high, even with newer triazole antifungal agents. We report a treatment regimen of cyclical caspofungin infusions in 10 patients with sarcoidosis and worsening CPA despite oral triazoles.
authors.affiliation: Royal Brompton Hospital, , London, UK.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Keir
authors.forename: Benjamin
authors.initials: B
authors.lastname: Garfield
authors.forename: David M
authors.initials: DM
authors.lastname: Hansell
authors.forename: Michael R
authors.initials: MR
authors.lastname: Loebinger
authors.forename: Robert
authors.initials: R
authors.lastname: Wilson
authors.forename: Elisabetta A
authors.initials: EA
authors.lastname: Renzoni
authors.forename: Athol U
authors.initials: AU
authors.lastname: Wells
authors.forename: Toby M
authors.initials: TM
authors.lastname: Maher
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077336:Caspofungin; D002908:Chronic Disease; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D007260:Infusion Pumps; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
keywords: Aspergillus Lung Disease; Sarcoidosis