title: The mid-fusiform sulcus: a landmark identifying both cytoarchitectonic and functional divisions of human ventral temporal cortex.
abstract: Human ventral temporal cortex (VTC) plays a pivotal role in high-level vision. An under-studied macroanatomical feature of VTC is the mid-fusiform sulcus (MFS), a shallow longitudinal sulcus separating the lateral and medial fusiform gyrus (FG). Here, we quantified the morphological features of the MFS in 69 subjects (ages 7-40), and investigated its relationship to both cytoarchitectonic and functional divisions of VTC with four main findings. First, despite being a minor sulcus, we found that the MFS is a stable macroanatomical structure present in all 138 hemispheres with morphological characteristics developed by age 7. Second, the MFS is the locus of a lateral-medial cytoarchitectonic transition within the posterior FG serving as the boundary between cytoarchitectonic regions FG1 and FG2. Third, the MFS predicts a lateral-medial functional transition in eccentricity bias representations in children, adolescents, and adults. Fourth, the anterior tip of the MFS predicts the location of a face-selective region, mFus-faces/FFA-2. These findings are the first to illustrate that a macroanatomical landmark identifies both cytoarchitectonic and functional divisions of high-level sensory cortex in humans and have important implications for understanding functional and structural organization in the human brain.
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA 94305, USA. Electronic address: kweiner@stanford.edu.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Weiner
authors.forename: Golijeh
authors.initials: G
authors.lastname: Golarai
authors.forename: Julian
authors.initials: J
authors.lastname: Caspers
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Chuapoco
authors.forename: Hartmut
authors.initials: H
authors.lastname: Mohlberg
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.forename: Kalanit
authors.initials: K
authors.lastname: Grill-Spector
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D059925:Anatomic Landmarks / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002648:Child; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010364:Pattern Recognition, Visual / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D055815:Young Adult
keywords: Cytoarchitectonics; Eccentricity bias; Fusiform face area; Fusiform gyrus; Mid-fusiform sulcus
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