title: Epstein-Barr virus (EBV) association and latency profile in pediatric Burkitt's lymphoma: experience of a single institution in Argentina.
abstract: The aim of this study is to characterize EBV expression and latency pattern in pediatric Burkitt's lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for two immunosuppressed patients who displayed LMP1 expression.
authors.affiliation: Molecular Biology Laboratory, Pathology Division, Ricardo Gutiérrez Children's Hospital, Gallo 1330, Buenos Aires, Argentina.
authors.forename: Julia
authors.initials: J
authors.lastname: Lara
authors.forename: Melina
authors.initials: M
authors.lastname: Cohen
authors.forename: Elena
authors.initials: E
authors.lastname: De Matteo
authors.forename: Luis
authors.initials: L
authors.lastname: Aversa
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Preciado
authors.forename: Paola
authors.initials: P
authors.lastname: Chabay
mesh_terms: D000293:Adolescent; D001118:Argentina / Q000453:epidemiology; D002051:Burkitt Lymphoma / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D020869:Gene Expression Profiling; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D012367:RNA, Viral / Q000096:biosynthesis; D012189:Retrospective Studies; D014764:Viral Proteins / Q000096:biosynthesis; D014775:Virus Activation; D017735:Virus Latency
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins
keywords: BHRF1; EBV; LMP1; childhood; latency; lymphoma