title: Radiolabeled probes targeting G-protein-coupled receptors for personalized medicine.
abstract: The G-protein coupled receptor system is involved in a range of cell types and actions and as such has a universal potential in identifying cell functions. The most widely explored system is that of the somatostatin receptors which has been exploited for both imaging and therapy. However, even with this fairly simple system, variation is seen in the behaviour of cells between patients and within different cell population within the patient. Newer work will exploit different ligands in a wider range of both tumour types and non-oncological processes such as inflammation.
authors.affiliation: Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK. john.buscombe@addenbrookes.nhs.uk.
authors.forename: John
authors.initials: J
authors.lastname: Buscombe
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D019275:Radiopharmaceuticals; D043562:Receptors, G-Protein-Coupled