title: Extracellular vesicle-mediated transfer of membranous components from the highly malignant T24 urinary carcinoma cell line to the non-malignant RT4 urinary papilloma cell line.
abstract: This communication reports the first experimental evidence that in the bladder cancer model, membranous components labelled with the DiO dye and the cholera toxin subunit B can be transported from highly malignant (T24) to non-malignant (RT4) cells by extracellular vesicles. Taking into account the presence of stable membranous nanostructures found by scanning electron microscopy, we suggest a possible uptake mechanism in recipient cells through fusion with highly curved membranous regions.
authors.affiliation: Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, 1000, Ljubljana, Slovenia.
authors.forename: Eva
authors.initials: E
authors.lastname: Ogorevc
authors.forename: Samo
authors.initials: S
authors.lastname: Hudoklin
authors.forename: Peter
authors.initials: P
authors.lastname: Veranič
authors.forename: Veronika
authors.initials: V
authors.lastname: Kralj-Iglič
mesh_terms: D045744:Cell Line, Tumor; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010212:Papilloma / Q000378:metabolism* / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000648:ultrastructure
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