title: Correlation of 18F-fluorodeoxyglucose uptake with histopathological prognostic factors in breast carcinoma.
abstract: OBJECTIVE
  This study investigated the prognostic value of [18F]-fluorodeoxyglucose (18F-FDG) uptake in breast carcinomas by comparing 18F-FDG PET/computed tomography (CT) images with histopathological and immunohistochemical prognostic factors.
  
  
  METHODS
  This study included 136 women and four men with positive biopsy breast carcinomas who underwent 18F-FDG PET/CT imaging for initial staging. Maximum standardized uptake values (SUVmax) and tumour-to-background SUVmax ratios were calculated and compared with histopathological and immunohistochemical tumour characteristics, patient properties and axillary lymph node involvement. Calculations of SUVmax for men were performed separately.
  
  
  RESULTS
  For the tumours in women, the mean SUVmax was 10.06±6.91 and the median SUVmax was 9.05 (0.7-35.0). Primary tumour 18F-FDG uptake and tumour-to-background SUVmax ratios were correlated with tumour size (P<0.001), histological type (P<0.001), histological grade (P=0.004), pleomorphism (P=0.010), mitosis count (P<0.001), lymphatic invasion (P=0.009), necrosis (P=0.005), oestrogen negativity (P=0.004), high Ki-67 level (P<0.001), axillary lymph node involvement (P<0.001) and triple negativity (P=0.002). High Ki-67 level (odds ratio=16; 95% confidence interval=1.6-160; P=0.016) and tumour size (odds ratio=4; 95% confidence interval=1.5-11; P=0.007) were determining factors for high 18F-FDG uptake values. Other clinicopathological and immunohistopathological parameters including progesterone receptor (P=0.211), CerbB2 overexpression (P=0.170), perineural invasion (P=0.053), intratumoural calcification (P=0.438), desmoplasia (P=0.112), tubular formation (P=0.768) and age (P=0.675) were not significantly correlated with 18F-FDG uptake. No significant relationship was observed between the tumour/contralateral breast SUVmax ratio and mitotic count, oestrogen receptor status or triple negativity.
  
  
  CONCLUSIONS
  F-FDG uptake may serve as a prognostic indicator for biological behaviour in breast tumours.
authors.affiliation: Departments of aNuclear Medicine bGeneral Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul cDepartment of Nuclear Medicine, Duzce University Medical Faculty, Duzce, Turkey.
authors.forename: Ozgul
authors.initials: O
authors.lastname: Ekmekcioglu
authors.forename: Anar
authors.initials: A
authors.lastname: Aliyev
authors.forename: Sabire
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Esra
authors.initials: E
authors.lastname: Arslan
authors.forename: Rana
authors.initials: R
authors.lastname: Kaya
authors.forename: Pinar
authors.initials: P
authors.lastname: Kocael
authors.forename: Melih Engin
authors.initials: ME
authors.lastname: Erkan
authors.forename: Metin
authors.initials: M
authors.lastname: Halac
authors.forename: Kerim
authors.initials: K
authors.lastname: Sonmezoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D018567:Breast Neoplasms, Male / Q000175:diagnosis / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18