title: Study of the histological profile of papillary thyroid carcinomas associated with Hashimoto's thyroiditis.
abstract: OBJECTIVE
  To investigate the association between the histological parameters of papillary thyroid cancer (PTC) and the presence of Hashimoto's thyroiditis (HT).
  
  
  METHODS
  Histological samples from patients with PTC were reviewed by an endocrine pathologist. The following parameters were analyzed: presence of concomitant HT, multifocality, presence of nodal metastasis, tumor size, vascular invasion, perineural infiltration, histological variant, and pathological staging. Clinical data included gender and age at the time of the diagnosis.
  
  
  RESULTS
  A total of 94 cases of PTC were reviewed. There was a predominance of women (85.1% vs. 14.9%) and median age at presentation was 45.13 years. The presence of HT was significantly associated with greater occurrence of multifocal tumors (p = 0.004), early pathological stage (p = 0.02), and smaller tumor size (p = 0.025).
  
  
  CONCLUSIONS
  Patients with PTC associated with HT had significantly smaller tumors, more often multifocal and in an earlier stage than their counterparts without HT. A better understanding of the immune response involved in these tumors may be useful for future strategies on the prevention and for the development of new therapeutic approaches for this group of neoplasms.
authors.forename: Maria Isabel Cunha Vieira
authors.initials: MI
authors.lastname: Cordioli
authors.forename: Adriano Namo
authors.initials: AN
authors.lastname: Cury
authors.forename: Adriana Oliveira
authors.initials: AO
authors.lastname: Nascimento
authors.forename: Ana Karine de
authors.initials: AK
authors.lastname: Oliveira
authors.forename: Murilo
authors.initials: M
authors.lastname: Mello
authors.forename: Mauro Ajaj
authors.initials: MA
authors.lastname: Saieg
mesh_terms: D002291:Carcinoma, Papillary / Q000473:pathology*; D005260:Female; D050031:Hashimoto Disease / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000473:pathology*