title: Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering.
abstract: Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple model that provides a general framework to describe the dynamical behavior of lipid-protein assemblies. Our results suggest that lipid-mediated interactions and cytoskeleton-anchored proteins contribute to the modulation of such behavior. In particular, we find a resonant condition between the membrane protein and cytoskeleton dynamics that results in the invariance of the ratio of clustered proteins that is found in in vivo experimental observations.
authors.affiliation: Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, SE-106 91 Stockholm Sweden.
authors.forename: Jordi
authors.initials: J
authors.lastname: Gómez-Llobregat
authors.forename: Javier
authors.initials: J
authors.lastname: Buceta
authors.forename: Ramon
authors.initials: R
authors.lastname: Reigada
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008055:Lipids / Q000737:chemistry; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding
chemical_list: D008055:Lipids; D008074:Lipoproteins; D008563:Membrane Lipids; D008565:Membrane Proteins
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