title: Major non-ABO incompatibility caused by anti-Jk(a) in a patient before allogeneic hematopoietic stem cell transplantation.
abstract: A 49-year-old white man with blood group AB, D+ was found to have alloanti-Jk(a) and -K when he developed a delayed hemolytic transfusion reaction before allogeneic hematopoietic stem cell transplant (HSCT). Given that his stem cell donor was blood group O, D+, Jk(a+), K-, rituximab was added to his conditioning regimen of fludarabine and melphalan to prevent hemolysis of engrafting Jk(a+) donor red blood cells. The patient proceeded to receive a peripheral blood stem cell transplant from a matched unrelated donor with no adverse events. To our knowledge, this is the first case of successful management of major non-ABO incompatibility caused by anti-Jk(a) in a patient receiving an allogeneic HSCT reported in the literature.
authors.affiliation: Division of Hematology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Kim
authors.forename: P
authors.initials: P
authors.lastname: Chaudhary
authors.forename: I A
authors.initials: IA
authors.lastname: Shulman
authors.forename: V
authors.initials: V
authors.lastname: Pullarkat
mesh_terms: D000937:Antigen-Antibody Reactions; D001663:Bilirubin / Q000097:blood; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility; D018380:Hematopoietic Stem Cell Transplantation; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001789:Blood Group Antigens; D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D001663:Bilirubin