title: Liver-specific deceased donor risk indices.
abstract: In order to assess the quality of the donor liver, procuring surgeons should accurately evaluate not only general donor risk indices, such as donor age, causes of brain death and cold ischemic time, but also consider the specific donor risk indices. In this review, we focus on liver-specific deceased donor risk indices, including liver steatosis, anti-hepatitis B core (HBc) positive or hepatitis C virus (HCV) positive donors, hypernatremia and anatomical variations. Liver steatosis is strongly associated with poor graft function after liver transplantation. Liver with more than 40-50% macrosteatosis should not be used. However, at present the quantity of fatty livers lack accepted standards. The computerized image analysis programs should be used to automate the determination of fat content in liver biopsy specimens. Liver grafts from anti-HBc positive donors can be safely used, preferentially in hepatitis B surface antigen (HBsAg) positive or anti-HBc/anti-HBs positive recipients. HCV positive allografts free from fibrosis or severe inflammation are a safe option for HCV positive recipients. The procurement team should consider liver biopsy to evaluate these HCV positive allografts. Donor serum sodium over 150 mm may predict a higher rate of graft primary non-functions. Recently, however, some investigators reported the sodium level likely has little clinical impact on post-transplant liver function. The incidence of hepatic artery variations has been reported to be approximately 30%. To avoid injuries, it is very important to know and identify these variations with precision at the time of organ procurement.
authors.affiliation: Department of Transplant, California Pacific Medical Center, San Francisco, California, USA; Department of General Surgery, First Affiliated Hospital, Xinxiang Medical University, Weihui, China.
authors.forename: Zifa
authors.initials: Z
authors.lastname: Wang
authors.forename: Garrett
authors.initials: G
authors.lastname: Hisatake
authors.forename: Libin
authors.initials: L
authors.lastname: Yang
keywords: anti-hepatitis B core positive donors; hepatic artery variations; hepatitis C virus positive allografts; liver steatosis; liver transplantation