title: [Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy].
abstract: To investigate the correlation of neurochemical metabolism in hippocampus with memory function in young adult patients with first-episode depression.
  
  
  
  Twenty patients with first-episode depression (patient group) and fifteen health subjects (control group) were enrolled in the study. The neurochemical metabolism, including the levels of N-acetylaspartate (NAA), Choline (Cho), Creatine (Cr), Myoinositol (mI) were measured by proton magnetic resonance spectroscope (1H-MRS) in bilateral hippocampus. Wechsler Memory Scale (WMS) were used to examine the memory function in both groups.
  
  
  
  The memory quotient (89.15 ±6.62) of patient group was significantly lower than that of controls (P <0.01),the scores of long-term memory,short-term memory and immediate memory in patients were also lower than those of controls (P<0.05 or 0.01). In patient group, the ratio of NAA/Cr (1.34 ±0.08) in the left hippocampus was significantly lower than that of control group (P<0.01); and the ratio of mI/Cr in the bilateral hippocampus [(0.63 ±0.13) in left and (0.6 ±0.1) in right] was significantly higher than those in control group (P<0.05). In patient group,the ratio of NAA/Cr in the left hippocampus was positively correlated with WMS scores (P<0.01), and the ratio of mI/Cr in the left hippocampus was negatively correlated with WMS scores (P<0.05).
  
  
  
  The memory deficit and abnormal metabolism function of neuron cell in hippocampus coexist in young adult patients with first-episode depression, and the lower NAA/Cr and higher mI/Cr ratio in the left hippocampus may result in the memory deficit.
authors.affiliation: The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Liu
authors.forename: Hualiang
authors.initials: H
authors.lastname: Yu
authors.forename: Biao
authors.initials: B
authors.lastname: Jiang
authors.forename: Leilei
authors.initials: L
authors.lastname: Zheng
authors.forename: Shaohua
authors.initials: S
authors.lastname: Yu
authors.forename: Bing
authors.initials: B
authors.lastname: Pan
authors.forename: Risheng
authors.initials: R
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016022:Case-Control Studies; D003401:Creatine / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine