title: Lumbar paravertebral blockade as intractable pain management method in palliative care.
abstract: Optimal symptoms control in advanced cancer disease, with refractory to conventional pain treatment, needs an interventional procedure. This paper presents coadministration of local anesthetic (LA) via paravertebral blockade (PVB) as the alternative to an unsuccessful subcutaneous fentanyl pain control in a 71-year old cancer patient with pathological fracture of femoral neck, bone metastases, and contraindications to morphine. Bupivacaine in continuous infusion (0.25%, 5 mL · hour(-1)) or in boluses (10 mL of 0.125%-0.5% solution), used for lumbar PVB, resulted in pain relief, decreased demand for opioids, and led to better social interactions. The factors contributing to an increased risk of systemic toxicity from LA in the patient were: renal impairment; heart failure; hypoalbuminemia; hypocalcemia; and a complex therapy with possible drug-drug interactions. These factors were taken into consideration during treatment. Bupivacaine's side effects were absent. Coadministered drugs could mask LA's toxicity. Elevated plasma α1-acid glycoprotein levels were a protective factor. To evaluate the benefit-risk ratio of the PVB treatment in boluses and in constant infusion, bupivacaine serum levels were determined and the drug plasma half-lives were calculated. Bupivacaine's elimination was slower when administered in constant infusion than in boluses (t½ = 7.80 hours versus 2.64 hours). Total drug serum concentrations remained within the safe ranges during the whole treatment course (22.9-927.4 ng mL(-1)). In the case presented, lumbar PVB with bupivacaine in boluses (≤ 137.5 mg · 24 hours(-1)) was an easy to perform, safe, effective method for pain control. Bupivacaine in continuous infusion (≤150 mg · 12 hours(-1)) had an acceptable risk-benefits ratio, but was ineffective.
authors.affiliation: Department of pharmacology, University Hospital of Lord's Transfiguration, Poland ; Palliative Medicine In-patient Unit, University Hospital of Lord's Transfiguration, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Zaporowska-Stachowiak
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kotlinska-Lemieszek
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kowalski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kosicka
authors.forename: Karolina
authors.initials: K
authors.lastname: Hoffmann
authors.forename: Franciszek
authors.initials: F
authors.lastname: Główka
authors.forename: Jacek
authors.initials: J
authors.lastname: Luczak
keywords: bone metastases; bupivacaine; intractable pain; opioid ineffectiveness
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