title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal sarcomatosis: long-term outcome from a single institution experience.
abstract: OBJECTIVE
  We assessed the long-term local disease-free survival (LDFS) and overall survival (OS) of patients with peritoneal sarcomatosis (PS) uniformly-treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS plus HIPEC).
  
  
  METHODS
  Retrospective data of 15 patients who underwent CS plus HIPEC for PS were extracted from a prospectively collected database. DFS and OS were calculated from the date of CS plus HIPEC to local relapse and death, respectively.
  
  
  RESULTS
  After a median follow-up of 28 months (range=4-144 months), median LDFS was 15 months (95% Confidence Interval CI=1-40 months). Median OS was 27 (95% CI=24.7-29.3) months. Long-term OS was achieved in three patients (20%) and ranged between 93 and 144 months. Female sex was the only factor significantly correlated with a greater LDFS (p=0.018). Patients with PS of visceral origin seem at lower risk of recurrence and death but the difference did not prove significant.
  
  
  CONCLUSIONS
  In our series, long-term survival was achieved in 20% of patients after CS plus HIPEC, with a benefit in female patients with PS of visceral origin. The impact of HIPEC after radical surgery for PS remains questionable and still has to be further evaluated in large cooperative multi-institutional studies.
authors.affiliation: Melanoma and Sarcoma Unit, Veneto Institute of Oncology, via Gattamelata 64, 35128 Padova, Italy. antonio.sommariva@ioveneto.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sommariva
authors.forename: Sandro
authors.initials: S
authors.lastname: Pasquali
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Fiore
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Montesco
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Pilati
authors.forename: Marco
authors.initials: M
authors.lastname: Rastrelli
authors.forename: Jude
authors.initials: J
authors.lastname: Niba
authors.forename: Donato
authors.initials: D
authors.lastname: Nitti
authors.forename: Carlo Riccardo
authors.initials: CR
authors.lastname: Rossi
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome
keywords: HIPEC; Peritoneal sarcomatosis; cytoreductive surgery; locoregional treatment