title: Ventilation and cardiac related impedance changes in children undergoing corrective open heart surgery.
abstract: Electrical impedance tomography (EIT) can determine ventilation and perfusion relationship. Most of the data obtained so far originates from experimental settings and in healthy subjects. The aim of this study was to demonstrate that EIT measures the perioperative changes in pulmonary blood flow after repair of a ventricular septum defect in children with haemodynamic relevant septal defects undergoing open heart surgery. In a 19 bed intensive care unit in a tertiary children's hospital ventilation and cardiac related impedance changes were measured using EIT before and after surgery in 18 spontaneously breathing patients. The EIT signals were either filtered for ventilation (ΔZV) or for cardiac (ΔZQ) related impedance changes. Impedance signals were then normalized (normΔZV, normΔZQ) for calculation of the global and regional impedance related ventilation perfusion relationship (normΔZV/normΔZQ). We observed a trend towards increased normΔZV in all lung regions, a significantly decreased normΔZQ in the global and anterior, but not the posterior lung region. The normΔZV/normΔZQ was significantly increased in the global and anterior lung region. Our study qualitatively validates our previously published modified EIT filtration technique in the clinical setting of young children with significant left-to-right shunt undergoing corrective open heart surgery, where perioperative assessment of the ventilation perfusion relation is of high clinical relevance.
authors.affiliation: Paediatric Critical Care Research Group, Mater Children's Hospital, South Brisbane, Queensland, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schibler
authors.forename: Trang M T
authors.initials: TM
authors.lastname: Pham
authors.forename: Amol A
authors.initials: AA
authors.lastname: Moray
authors.forename: Christian
authors.initials: C
authors.lastname: Stocker
mesh_terms: D002675:Child, Preschool; D017097:Electric Impedance; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006345:Heart Septal Defects, Ventricular / Q000503:physiopathology / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008297:Male; D057234:Preoperative Period; D012123:Pulmonary Ventilation; D013903:Thoracic Surgery; D014054:Tomography; D014692:Ventilation-Perfusion Ratio