title: Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders.
abstract: Livedoid vasculopathy is a bilateral painful and recurrent cutaneous ulcerative disorder of the legs that leads to atrophie blanche, atrophic white-porcelain scars, and is associated with disorders of fibrinolysis and/or coagulation. We present a young boy with an association between livedoid vasculopathy in the area of a previous involuted cutaneous hemangioma. We found 4 uncommon abnormalities associated with thrombo-occlusive events: heterozygous 20210 A→G genotype of prothrombin, reduced activity of anticoagulation proteins C and S, and elevated lipoprotein (a).
authors.affiliation: 1University of Sao Paulo Medical School, Sao Paolo, Brazil.
authors.forename: Paulo Ricardo
authors.initials: PR
authors.lastname: Criado
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Alavi
authors.forename: Ilana
authors.initials: I
authors.lastname: Halpern
authors.forename: Mirian Nacagami
authors.initials: MN
authors.lastname: Sotto
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
mesh_terms: D000293:Adolescent; D001241:Aspirin / Q000008:administration & dosage*; D001706:Biopsy; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D001780:Blood Coagulation Tests; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006652:Histological Techniques / Q000379:methods; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D054068:Livedo Reticularis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008297:Male; D010431:Pentoxifylline / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011516:Prothrombin / Q000235:genetics; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler / Q000379:methods
chemical_list: D010975:Platelet Aggregation Inhibitors; D011516:Prothrombin; D001241:Aspirin; D010431:Pentoxifylline
keywords: atrophie blanche; hemangioma; livedoid vasculopathy