title: Innate sensing of viruses by pattern recognition receptors in birds.
abstract: Similar to mammals, several viral-sensing pattern recognition receptors (PRR) have been identified in birds including Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLR). Avian TLR are slightly different from their mammalian counterparts, including the pseudogene TLR8, the absence of TLR9, and the presence of TLR1La, TLR1Lb, TLR15, and TLR21. Avian TLR3 and TLR7 are involved in RNA virus recognition, especially highly pathogenic avian influenza virus (HPAIV), while TLR15 and TLR21 are potential sensors that recognize both RNA viruses and bacteria. However, the agonist of TLR15 is still unknown. Interestingly, chickens, unlike ducks, geese and finches, lack RIG-I, however they do express melanoma differentiation-associated gene 5 (MDA5) which functionally compensates for the absence of RIG-I. Duck RIG-I is the cytosolic recognition element for HPAIV recognition, while chicken cells sense HPAIV through MDA5. However, the contributions of MDA5 and RIG-I to IFN-β induction upon HPAIV infection is different, and this may contribute to the chicken's susceptibility to highly pathogenic influenza. It is noteworthy that the interactions between avian DNA viruses and PRR have not yet been reported. Furthermore, the role for avian Nod-like receptors (NLR) in viral immunity is largely unknown. In this review, recent advances in the field of viral recognition by different types of PRR in birds are summarized. In particular, the tissue and cellular distribution of avian PRR, the recognition and activation of PRR by viruses, and the subsequent expression of innate antiviral genes such as type I IFN and proinflammatory cytokines are discussed.
authors.affiliation: Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. sophia_cs@163.com.
authors.forename: Shun
authors.initials: S
authors.lastname: Chen
authors.forename: Anchun
authors.initials: A
authors.lastname: Cheng
authors.forename: Mingshu
authors.initials: M
authors.lastname: Wang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D007113:Immunity, Innate; D009928:Organ Specificity; D011200:Poultry; D011201:Poultry Diseases / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D051192:Receptors, Pattern Recognition / Q000235:genetics* / Q000378:metabolism; D014780:Viruses / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition
references.citation: Cell Tissue Res. 2011 Jan;343(1):121-30
references.pmid: 20809414
references.citation: Dev Comp Immunol. 2008;32(4):435-44
references.pmid: 17870162
references.citation: Mol Immunol. 2013 May;54(1):89-97
references.pmid: 23220072
references.citation: Biol Pharm Bull. 2005 May;28(5):886-92
references.pmid: 15863899
references.citation: Dev Comp Immunol. 2012 Apr;36(4):756-60
references.pmid: 22120532
references.citation: J Immunol. 2010 Aug 1;185(3):1681-91
references.pmid: 20610642
references.citation: Cytogenet Genome Res. 2007;117(1-4):221-30
references.pmid: 17675863
references.citation: Crit Rev Immunol. 2010;30(6):489-513
references.pmid: 21175414
references.citation: J Virol. 2008 Jan;82(1):335-45
references.pmid: 17942531
references.citation: BMC Evol Biol. 2011 May 28;11:149
references.pmid: 21619680
references.citation: Mol Biol Rep. 2012 Aug;39(8):8539-49
references.pmid: 22699880
references.citation: BMC Res Notes. 2012 Nov 01;5:616
references.pmid: 23116495
references.citation: Mol Biol Evol. 2011 May;28(5):1703-15
references.pmid: 21239391
references.citation: Infect Immun. 2003 Mar;71(3):1116-24
references.pmid: 12595422
references.citation: J Gen Virol. 2007 Nov;88(Pt 11):3089-3093
references.pmid: 17947534
references.citation: Poult Sci. 2013 Mar;92(3):645-54
references.pmid: 23436515
references.citation: J Exp Med. 2008 Jul 7;205(7):1601-10
references.pmid: 18591409
references.citation: Res Vet Sci. 2013 Aug;95(1):87-91
references.pmid: 23433682
references.citation: PLoS Pathog. 2006 Jun;2(6):e53
references.pmid: 16789835
references.citation: BMC Genomics. 2010 Oct 08;11:545
references.pmid: 20929591
references.citation: Biochem Cell Biol. 2004 Jun;82(3):401-5
references.pmid: 15181474
references.citation: Avian Pathol. 2010 Oct;39(5):309-24
references.pmid: 20954007
references.citation: J Biol Chem. 2001 Dec 14;276(50):47143-9
references.pmid: 11590137
references.citation: Biochem Soc Trans. 2007 Dec;35(Pt 6):1504-7
references.pmid: 18031254
references.citation: J Virol. 2012 Jan;86(2):705-17
references.pmid: 22072756
references.citation: Annu Rev Pathol. 2009;4:365-98
references.pmid: 18928408
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5913-8
references.pmid: 20308570
references.citation: Immunol Lett. 2007 May 15;110(1):86-9
references.pmid: 17467809
references.citation: Nat Immunol. 2010 May;11(5):373-84
references.pmid: 20404851
references.citation: Virol J. 2012 Aug 03;9:145
references.pmid: 22862800
references.citation: Nature. 2001 Oct 18;413(6857):732-8
references.pmid: 11607032
references.citation: Eur J Immunol. 2003 Nov;33(11):2987-97
references.pmid: 14579267
references.citation: Avian Dis. 2009 Jun;53(2):261-7
references.pmid: 19630234
references.citation: PLoS One. 2011;6(8):e23103
references.pmid: 21826229
references.citation: J Immunol. 2011 May 1;186(9):5397-405
references.pmid: 21444763
references.citation: Blood. 2004 Feb 15;103(4):1433-7
references.pmid: 14563635
references.citation: Immunology. 2005 Apr;114(4):507-21
references.pmid: 15804288
references.citation: Br Poult Sci. 2012;53(2):190-7
references.pmid: 22646784
references.citation: Avian Pathol. 2012 Dec;41(6):519-29
references.pmid: 23237364
references.citation: Nat Rev Mol Cell Biol. 2003 Feb;4(2):95-104
references.pmid: 12563287
references.citation: Viral Immunol. 2012 Oct;25(5):394-401
references.pmid: 22857262
references.citation: Trends Genet. 1995 May;11(5):190-4
references.pmid: 7785078
references.citation: Mol Immunol. 2012 Oct;52(3-4):117-24
references.pmid: 22673209
references.citation: BMC Vet Res. 2012 Mar 08;8:23
references.pmid: 22401171
references.citation: Vet Immunol Immunopathol. 2005 Mar 10;104(1-2):117-27
references.pmid: 15661337
references.citation: Virology. 2007 Mar 1;359(1):190-200
references.pmid: 17049367
references.citation: Immunol Rev. 2009 Jan;227(1):75-86
references.pmid: 19120477
references.citation: BMC Genomics. 2008 Feb 01;9:62
references.pmid: 18241342
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9577-82
references.pmid: 15976025
references.citation: BMC Evol Biol. 2009 Apr 28;9:85
references.pmid: 19400936
references.citation: Res Vet Sci. 2009 Jun;86(3):399-405
references.pmid: 18977008
references.citation: Mol Immunol. 2009 May;46(8-9):1744-9
references.pmid: 19250679
references.citation: Poult Sci. 2012 Oct;91(10):2475-81
references.pmid: 22991530
references.citation: Vet Res. 2011 Jul 12;42:85
references.pmid: 21749706
references.citation: Mol Cell. 2008 Feb 29;29(4):428-40
references.pmid: 18242112
references.citation: Virus Res. 2011 Jul;159(1):32-42
references.pmid: 21557972
references.citation: Science. 2006 Nov 10;314(5801):997-1001
references.pmid: 17038589
references.citation: J Virol. 2007 Feb;81(4):2025-30
references.pmid: 17151098
references.citation: Virology. 2009 Oct 25;393(2):250-7
references.pmid: 19733379
references.citation: Nat Immunol. 2004 Jul;5(7):730-7
references.pmid: 15208624
references.citation: Infect Immun. 2005 Apr;73(4):2344-50
references.pmid: 15784580
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
references.pmid: 20080593
references.citation: J Interferon Cytokine Res. 2005 Aug;25(8):467-84
references.pmid: 16108730
references.citation: Int J Oncol. 2012 Jan;40(1):287-98
references.pmid: 21971670
references.citation: Annu Rev Biochem. 2005;74:355-83
references.pmid: 15952891
references.citation: Vet Immunol Immunopathol. 2013 May 15;153(1-2):99-106
references.pmid: 23481654
references.citation: J Interferon Cytokine Res. 2007 Feb;27(2):97-101
references.pmid: 17316136
references.citation: Clin Exp Immunol. 2005 Jun;140(3):395-407
references.pmid: 15932500
references.citation: Mol Biol Rep. 2012 Apr;39(4):3419-26
references.pmid: 21717059
references.citation: J Immunol. 2010 Feb 15;184(4):1990-2000
references.pmid: 20061403
references.citation: Curr Opin Immunol. 2007 Dec;19(6):615-22
references.pmid: 17977705
references.citation: Mol Immunol. 2011 Mar;48(6-7):924-30
references.pmid: 21256597
references.citation: Dev Comp Immunol. 2005;29(9):791-807
references.pmid: 15936435
references.citation: EMBO J. 2006 Sep 20;25(18):4207-14
references.pmid: 16946700
references.citation: Microbes Infect. 2006 Jun;8(7):1866-74
references.pmid: 16815069
references.citation: Nature. 2008 Mar 6;452(7183):103-7
references.pmid: 18288107
references.citation: J Immunol. 2010 Jul 1;185(1):460-7
references.pmid: 20498358
references.citation: Mol Immunol. 2009 Sep;46(15):3163-70
references.pmid: 19573927
references.citation: J Exp Med. 2003 Aug 4;198(3):513-20
references.pmid: 12900525
references.citation: Nature. 2006 May 4;441(7089):101-5
references.pmid: 16625202
references.citation: Comp Immunol Microbiol Infect Dis. 2012 Jul;35(4):335-43
references.pmid: 22459580
references.citation: PLoS One. 2012;7(12):e49952
references.pmid: 23227156
references.citation: Semin Immunol. 2007 Feb;19(1):33-40
references.pmid: 17336545
references.citation: Benef Microbes. 2012 Sep;3(3):205-10
references.pmid: 22968409
references.citation: J Interferon Cytokine Res. 2012 Jan;32(1):46-51
references.pmid: 21929369
references.citation: Viral Immunol. 2010 Jun;23(3):309-19
references.pmid: 20565294
references.citation: Infect Immun. 2006 Mar;74(3):1692-8
references.pmid: 16495540
references.citation: Cell. 2010 Apr 30;141(3):483-96
references.pmid: 20434986
references.citation: Science. 2006 Nov 10;314(5801):994-7
references.pmid: 17038590
references.citation: Mol Immunol. 2013 Apr;53(4):321-7
references.pmid: 23063767
references.citation: Dev Comp Immunol. 2011 Mar;35(3):392-8
references.pmid: 21095203
references.citation: Nat Immunol. 2006 Feb;7(2):131-7
references.pmid: 16424890
references.citation: Vet Immunol Immunopathol. 2007 Feb 15;115(3-4):216-22
references.pmid: 17157392
references.citation: Vaccine. 2012 Jun 22;30(30):4524-31
references.pmid: 22531557
references.citation: Mol Immunol. 2008 Apr;45(7):2055-61
references.pmid: 18036663
references.citation: J Immunol. 2010 Jun 15;184(12):6993-7000
references.pmid: 20483729