title: Postantibiotic effects and postantibiotic sub-MIC effects of tilmicosin, erythromycin and tiamulin on erythromycin-resistant Streptococcus suis.
abstract: The postantibiotic effects (PAEs) and postantibiotic sub-MIC effects (PA SMEs) of tilmicosin, erythromycin and tiamulin on erythromycin-susceptible and erythromycin-resistant strains of Streptococcus suis (M phenotype) were investigated in vitro. Tilmicosin and tiamulin induced significantly longer PAE and PA SME against both erythromycin-susceptible and erythromycin-resistant strains than did erythromycin. The durations of PAE and PA SMEs were proportional to the concentrations of drugs used for exposure. The PA SMEs were substantially longer than PAEs on S. suis (P<0.05) regardless of the antimicrobial used for exposure. The results indicated that the PAE and PA SME could help in the design of efficient control strategies for infection especially caused by erythromycin-resistant S. suis and that they may provide additional valuable information for the rational drug use in clinical practice.
authors.affiliation: College of Veterinary Medicine, Nanjing Agricultural University , Nanjing 210095 , China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Yuanshu
authors.initials: Y
authors.lastname: Zhang
keywords: Postantibiotic effects; erythromycin; erythromycin-resistant Streptococcus suis; postantibiotic sub-MIC effects; tiamulin; tilmicosin
references.citation: Vet Microbiol. 2005 Jan 31;105(2):143-7
references.pmid: 15627526
references.citation: Antimicrob Agents Chemother. 1996 Nov;40(11):2562-6
references.pmid: 8913465
references.citation: J Vet Pharmacol Ther. 2008 Dec;31(6):591-4
references.pmid: 19000285
references.citation: Vet Microbiol. 2008 Oct 15;131(3-4):386-92
references.pmid: 18499362
references.citation: Avian Dis. 1996 Apr-Jun;40(2):326-34
references.pmid: 8790882
references.citation: Antimicrob Agents Chemother. 1992 Sep;36(9):1852-8
references.pmid: 1329631
references.citation: Vet Microbiol. 2006 Mar 10;113(1-2):73-82
references.pmid: 16387456
references.citation: Int J Antimicrob Agents. 2004 Oct;24(4):362-8
references.pmid: 15380262
references.citation: Antimicrob Agents Chemother. 2006 Nov;50(11):3956-8
references.pmid: 17065631
references.citation: Poult Sci. 2006 Mar;85(3):441-5
references.pmid: 16553273
references.citation: Int J Antimicrob Agents. 1999 Aug;12(3):229-37
references.pmid: 10461841
references.citation: J Am Vet Med Assoc. 1990 Dec 1;197(11):1467-70
references.pmid: 2272877
references.citation: Med J Aust. 2008 Oct 6;189(7):413
references.pmid: 18837692
references.citation: Lancet Infect Dis. 2007 Mar;7(3):201-9
references.pmid: 17317601
references.citation: Int J Antimicrob Agents. 2004 Sep;24(3):254-60
references.pmid: 15325429
references.citation: Vet Microbiol. 2001 Nov 26;83(3):287-97
references.pmid: 11574176
references.citation: J Antimicrob Chemother. 2003 Nov;52(5):809-12
references.pmid: 14519674
references.citation: J Antimicrob Chemother. 1993 Dec;32(6):885-91
references.pmid: 8144429
references.citation: Jpn J Antibiot. 2007 Feb;60(1):31-46
references.pmid: 17436861
references.citation: Poult Sci. 2008 Dec;87(12):2528-34
references.pmid: 19038809
references.citation: Diagn Microbiol Infect Dis. 2000 Apr;36(4):241-7
references.pmid: 10764966
references.citation: Vet Rec. 2007 Dec 22-29;161(25):864
references.pmid: 18156600
references.citation: J Antimicrob Chemother. 2007 Jun;59(6):1171-6
references.pmid: 17405779
references.citation: J Antimicrob Chemother. 1991 Feb;27(2):157-60
references.pmid: 2055808
references.citation: Acta Vet Scand. 2008 Jun 13;50:19
references.pmid: 18554407
references.citation: Diagn Microbiol Infect Dis. 2007 Apr;57(4):419-22
references.pmid: 17188449
references.citation: Emerg Infect Dis. 2006 Jun;12(6):914-20
references.pmid: 16707046
references.citation: J Antimicrob Chemother. 1993 Jun;31(6):881-92
references.pmid: 8360126