title: Protective effect of a pomace olive oil concentrated in triterpenic acids in alterations related to hypertension in rats: mechanisms involved.
abstract: METHODS
  Despite the amount of information and research on the effects of virgin olive oil and its components in cardiovascular disease, little attention has been paid to the effects of pomace olive oil, an olive oil subproduct traditionally used in Spain. The aim of the present study was to evaluate the potential effects of a pomace olive oil concentrated in triterpenic acids (POCTA) on blood pressure, cardiac hemodynamics, and functional and molecular vascular alterations associated with hypertension in spontaneously hypertensive rats (SHR).
  
  
  RESULTS
  The study showed that POCTA attenuated the increase of blood pressure in SHR. This effect was associated with an improvement in endothelium-dependent relaxation, enhancement of vascular expression of endothelial nitric oxide synthase, and reduction of tumor necrosis factor alpha, transforming growth factor beta, and collagen I. Furthermore, POCTA improved cardiac hemodynamics (left ventricular systolic pressure and left ventricular end-diastolic pressure) and decreased relative kidney and lung weights.
  
  
  CONCLUSIONS
  POCTA exerts antihypertensive effects together with vascular and hypertension target organ protection in SHR. Since interest in pomace olive oil has been low, the results of this study contribute to increasing awareness of its biological and nutritional values.
authors.affiliation: Department of Physiology, School of Medicine, Universidad Complutense, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Valero-Muñoz
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martín-Fernández
authors.forename: Sandra
authors.initials: S
authors.lastname: Ballesteros
authors.forename: Esther
authors.initials: E
authors.lastname: de la Fuente
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Quintela
authors.forename: Vicente
authors.initials: V
authors.lastname: Lahera
authors.forename: Natalia
authors.initials: N
authors.lastname: de las Heras
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR; D013030:Spain; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D014315:Triterpenes / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D000069463:Olive Oil; D010938:Plant Oils; D016212:Transforming Growth Factor beta; D014315:Triterpenes; D014409:Tumor Necrosis Factor-alpha; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat
keywords: Endothelial dysfunction; Fibrosis; Hypertension; Inflammation; Pomace olive oil; Triterpenic acids