title: Control of the superior colliculus by the lateral prefrontal cortex.
abstract: Several decades of patient, functional imaging and neurophysiological studies have supported a model in which the lateral prefrontal cortex (PFC) acts to suppress unwanted saccades by inhibiting activity in the oculomotor system. However, recent results from combined PFC deactivation and neural recordings of the superior colliculus in monkeys demonstrate that the primary influence of the PFC on the oculomotor system is excitatory, and stands in direct contradiction to the inhibitory model of PFC function. Although erroneous saccades towards a visual stimulus are commonly labelled reflexive in patients with PFC damage or dysfunction, the latencies of most of these saccades are outside of the range of express saccades, which are triggered directly by the visual stimulus. Deactivation and pharmacological manipulation studies in monkeys suggest that response errors following PFC damage or dysfunction are not the result of a failure in response suppression but can best be understood in the context of a failure to maintain and implement the proper task set.
authors.affiliation: Department of Physiology and Pharmacology, University of Western Ontario, , London, Ontario, Canada.
authors.forename: Stefan
authors.initials: S
authors.lastname: Everling
authors.forename: Kevin
authors.initials: K
authors.lastname: Johnston
mesh_terms: D000818:Animals; D008251:Macaca; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000473:pathology / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology*; D013997:Time Factors
keywords: eye movements; inhibition; prefrontal cortex; primates
references.citation: Eur J Neurosci. 2013 Jan;37(2):330-8
references.pmid: 23121177
references.citation: Psychophysiology. 2009 Sep;46(5):1100-7
references.pmid: 19497008
references.citation: Trends Cogn Sci. 2011 Oct;15(10):453-9
references.pmid: 21889391
references.citation: Annu Rev Neurosci. 2008;31:219-45
references.pmid: 18558854
references.citation: Neurosci Lett. 1981 Jan 20;21(2):137-42
references.pmid: 7219863
references.citation: Exp Brain Res. 2008 Oct;190(4):463-73
references.pmid: 18641976
references.citation: Eur J Neurosci. 2009 Dec 3;30(11):2165-76
references.pmid: 20128852
references.citation: Neurosci Lett. 1984 Aug 24;49(1-2):7-12
references.pmid: 6493600
references.citation: J Comp Neurol. 1992 May 8;319(2):191-204
references.pmid: 1381727
references.citation: J Neurophysiol. 1989 Apr;61(4):799-813
references.pmid: 2723721
references.citation: Cereb Cortex. 1998 Jan-Feb;8(1):40-7
references.pmid: 9510384
references.citation: Nat Rev Neurosci. 2004 Mar;5(3):218-28
references.pmid: 14976521
references.citation: Exp Brain Res. 1998 Jan;118(1):27-34
references.pmid: 9547075
references.citation: Psychophysiology. 2006 May;43(3):302-13
references.pmid: 16805870
references.citation: Brain. 1991 Jun;114 ( Pt 3):1473-85
references.pmid: 2065261
references.citation: Psychol Bull. 2000 Mar;126(2):220-46
references.pmid: 10748641
references.citation: Cogn Psychol. 1996 Jun;30(3):257-303
references.pmid: 8660786
references.citation: Nat Rev Neurosci. 2001 Nov;2(11):820-9
references.pmid: 11715058
references.citation: Cereb Cortex. 2007 Jan;17(1):221-9
references.pmid: 16481562
references.citation: Front Comput Neurosci. 2010 Oct 04;4:24
references.pmid: 21048899
references.citation: Neuroscience. 1981;6(6):1023-41
references.pmid: 6168970
references.citation: J Neurophysiol. 1996 Dec;76(6):4040-55
references.pmid: 8985899
references.citation: Neuron. 2003 May 22;38(4):637-48
references.pmid: 12765614
references.citation: J Neurophysiol. 2012 May;107(9):2463-74
references.pmid: 22298826
references.citation: J Neurosci. 1997 Nov 1;17(21):8566-79
references.pmid: 9334428
references.citation: J Neurophysiol. 2009 Oct;102(4):2334-41
references.pmid: 19692516
references.citation: Annu Rev Psychol. 2004;55:23-50
references.pmid: 14744209
references.citation: J Cogn Neurosci. 2006 May;18(5):749-65
references.pmid: 16768375
references.citation: J Neurophysiol. 2005 Sep;94(3):1707-26
references.pmid: 16105954
references.citation: Can J Physiol Pharmacol. 2000 Nov;78(11):934-44
references.pmid: 11100942
references.citation: Exp Brain Res. 1984;57(1):191-5
references.pmid: 6519226
references.citation: J Neurophysiol. 1998 Sep;80(3):1584-9
references.pmid: 9744965
references.citation: J Cogn Neurosci. 2005 Sep;17(9):1483-96
references.pmid: 16197701
references.citation: Biol Psychiatry. 2005 May 15;57(10):1159-65
references.pmid: 15866556
references.citation: J Neurophysiol. 2001 Feb;85(2):804-15
references.pmid: 11160514
references.citation: Neuroimage. 2007 Jul 1;36(3):774-84
references.pmid: 17478104
references.citation: Ann Neurol. 2003 Apr;53(4):542-5
references.pmid: 12666125
references.citation: Brain Res. 1978 Aug 4;151(2):235-44
references.pmid: 209862
references.citation: J Neurosci. 2009 Apr 29;29(17):5516-24
references.pmid: 19403819
references.citation: J Neurophysiol. 2007 Sep;98(3):1751-62
references.pmid: 17596416
references.citation: Science. 1996 Oct 18;274(5286):427-30
references.pmid: 8832893
references.citation: Exp Brain Res. 1985;58(3):455-72
references.pmid: 4007089
references.citation: Brain Res. 1976 Oct 29;116(1):145-9
references.pmid: 824019
references.citation: J Neurosci. 2000 Jan 1;20(1):387-400
references.pmid: 10627615
references.citation: J Neurophysiol. 2003 Feb;89(2):1016-23
references.pmid: 12574477
references.citation: J Neurosci. 2012 May 16;32(20):7034-41
references.pmid: 22593071
references.citation: Neurosci Res. 1990 Nov;9(2):79-102
references.pmid: 1980528
references.citation: J Neurophysiol. 2005 Jul;94(1):429-40
references.pmid: 15728770
references.citation: J Neurophysiol. 2000 Nov;84(5):2595-604
references.pmid: 11068001
references.citation: J Neurosci. 2005 Nov 9;25(45):10347-50
references.pmid: 16280570
references.citation: Trends Neurosci. 2000 Oct;23(10):475-83
references.pmid: 11006464
references.citation: J Neurosci. 2011 Jul 27;31(30):10872-81
references.pmid: 21795539
references.citation: J Neurosci. 2006 Nov 29;26(48):12471-8
references.pmid: 17135409
references.citation: Brain Cogn. 2008 Dec;68(3):271-83
references.pmid: 18940273
references.citation: J Neurophysiol. 1989 Apr;61(4):780-98
references.pmid: 2723720
references.citation: J Neurosci. 2003 Jul 23;23(16):6480-9
references.pmid: 12878689
references.citation: Brain. 2003 Jun;126(Pt 6):1460-73
references.pmid: 12764065
references.citation: J Neurosci. 1999 Apr 1;19(7):2740-54
references.pmid: 10087086
references.citation: Trends Cogn Sci. 2010 Apr;14(4):172-9
references.pmid: 20171926
references.citation: Brain Res. 1987 Dec 22;437(1):45-55
references.pmid: 3427482
references.citation: Vis Neurosci. 1995 Sep-Oct;12(5):929-37
references.pmid: 8924416
references.citation: Br Med J. 1938 Jul 16;2(4045):107-12
references.pmid: 20781594
references.citation: Eur J Neurosci. 1999 Mar;11(3):1011-36
references.pmid: 10103094
references.citation: Brain Cogn. 2008 Dec;68(3):255-70
references.pmid: 18835656
references.citation: Biol Psychiatry. 1994 Jul 1;36(1):21-30
references.pmid: 8080899
references.citation: Vision Res. 1984;24(10):1233-46
references.pmid: 6395480
references.citation: Cereb Cortex. 2014 May;24(5):1373-88
references.pmid: 23307633
references.citation: J Neurophysiol. 1998 Mar;79(3):1193-209
references.pmid: 9497401
references.citation: Brain Res. 1983 Jan 31;260(1):21-6
references.pmid: 6402272
references.citation: J Comp Neurol. 1984 Nov 20;230(1):55-76
references.pmid: 6096414
references.citation: Vision Res. 2004 Jun;44(12):1453-67
references.pmid: 15066404
references.citation: J Neurosci. 2011 Jun 8;31(23):8659-68
references.pmid: 21653870
references.citation: Neuropsychologia. 1998 Nov;36(11):1141-59
references.pmid: 9842760
references.citation: Neuropsychologia. 1998 Sep;36(9):885-99
references.pmid: 9740362
references.citation: J Exp Psychol Gen. 2008 Feb;137(1):131-48
references.pmid: 18248133
references.citation: J Comp Neurol. 1990 Jun 1;296(1):47-64
references.pmid: 1694189
references.citation: J Neurosci. 2006 Mar 8;26(10):2724-31
references.pmid: 16525051
references.citation: Neuropsychologia. 1996 Jun;34(6):475-83
references.pmid: 8736560
references.citation: Exp Brain Res. 1992;89(2):415-24
references.pmid: 1623983