title: [Cardiovascular effects and pathophysiological significance of adrenomedullin family peptides].
abstract: Adrenomedullin family includes adrenomedullin (ADM), intermedin (IMD) and different peptide fragments derived from prepro-ADM or prepro-IMD. Recent researches found the interaction between different prepro-peptides or different peptide fragments, which plays a crucial role in maintaining homeostasis of cardiovascular system as well as participates in the occurrence and development of cardiovascular disease. This review intends to introduce cardiovascular effects and pathophysiological significance of adrenomedullin family peptides from function level, receptor level and signaling pathway.
authors.affiliation: Laboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Lu
authors.forename: Yong-Fen
authors.initials: YF
authors.lastname: Qi
mesh_terms: D053607:Adrenomedullin / Q000502:physiology*; D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002319:Cardiovascular System / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D010446:Peptide Fragments / Q000502:physiology*; D036361:Peptide Hormones / Q000502:physiology*
chemical_list: C484330:ADM2 protein, human; D010446:Peptide Fragments; D036361:Peptide Hormones; D053607:Adrenomedullin