title: Antibiotic susceptibility patterns and prevalence of group B Streptococcus isolated from pregnant women in Misiones, Argentina.
abstract: This study was performed to determine the susceptibility patterns and the colonization rate of Group B Streptococcus (GBS) in a population of pregnant women. From January 2004 to December 2006, vaginal-rectal swabs were obtained from 1105 women attending Dr. Ramón Madariaga Hospital, in Posadas, Misiones, Argentina. The carriage rate of GBS among pregnant women was 7.6%. A total of 62 GBS strains were randomly selected for in vitro susceptibility testing to penicillin G, ampicillin, tetracycline, levofloxacin, gatifloxacin, ciprofloxacin, quinupristin-dalfopristin, linezolid, vancomycin, rifampicin, trimethoprim- sulfametoxazol, nitrofurantoin, gentamicin, clindamycin and erythromycin, and determination of resistance phenotypes. No resistance to penicillin, ampicillin, quinupristin-dalfopristin, linezolid, and vancomycin was found. Of the isolates examined 96.8%, 98.3%, 46.8%, and 29.0% were susceptible to rifampicin, nitrofurantoin, trimethoprim-sulfametoxazol and tetracycline, respectively. Rank order of susceptibility for the quinolones was: gatifloxacin (98.4%) > levofloxacin (93.5%) > ciprofloxacin (64.5%). The rate of resistance to erythromycin (9.7%) was higher than that of other reports from Argentina. High-level resistance to gentamicin was not detected in any of the isolates. Based on our finding of 50% of GBS isolates with MIC to gentamicin equal o lower than 8 μg/ml, a concentration used in one of the selective media recommended for GBS isolation, we suggested, at least in our population, the use of nalidixic acid and colistin in selective media with the aim to improve the sensitivity of screening cultures for GBS carriage in women.
authors.affiliation: Universidad Nacional de Misiones , Posadas, Misiones , Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Quiroga
authors.forename: E
authors.initials: E
authors.lastname: Pegels
authors.forename: P
authors.initials: P
authors.lastname: Oviedo
authors.forename: E
authors.initials: E
authors.lastname: Pereyra
authors.forename: M
authors.initials: M
authors.lastname: Vergara
keywords: Argentina; Group B Streptococcus; antibiotic susceptibility; pregnant women; prevalence
references.citation: Am J Trop Med Hyg. 1998 Oct;59(4):633-6
references.pmid: 9790443
references.citation: Pediatrics. 1999 Aug;104(2 Pt 1):203-9
references.pmid: 10428995
references.citation: Antimicrob Agents Chemother. 2001 Nov;45(11):3205-8
references.pmid: 11600380
references.citation: Scand J Infect Dis. 2000;32(3):339-40
references.pmid: 10879617
references.citation: Obstet Gynecol. 1998 Aug;92(2):258-61
references.pmid: 9699763
references.citation: Antimicrob Agents Chemother. 2004 Nov;48(11):4444-6
references.pmid: 15504878
references.citation: J Antimicrob Chemother. 2001 May;47(5):675-80
references.pmid: 11328783
references.citation: J Clin Microbiol. 1990 Jan;28(1):5-7
references.pmid: 2405014
references.citation: Medicina (B Aires). 2001;61(3):295-300
references.pmid: 11474877
references.citation: J Clin Microbiol. 1979 Apr;9(4):466-70
references.pmid: 379037
references.citation: MMWR Morb Mortal Wkly Rep. 1997 May 30;46(21):473-7
references.pmid: 9182211
references.citation: J Clin Microbiol. 2003 Oct;41(10):4688-94
references.pmid: 14532204
references.citation: MMWR Recomm Rep. 2002 Aug 16;51(RR-11):1-22
references.pmid: 12211284
references.citation: Clin Infect Dis. 2000 Jul;31(1):76-9
references.pmid: 10913400
references.citation: Pediatr Infect Dis J. 1990 Mar;9(3):224-5
references.pmid: 2186355
references.citation: Rev Argent Microbiol. 2005 Jul-Sep;37(3):142-4
references.pmid: 16323663
references.citation: J Matern Fetal Neonatal Med. 2004 Apr;15(4):267-74
references.pmid: 15280136
references.citation: Rev Argent Microbiol. 2003 Oct-Dec;35(4):183-7
references.pmid: 14976869
references.citation: Am J Obstet Gynecol. 2000 Oct;183(4):859-62
references.pmid: 11035326
references.citation: Rev Argent Microbiol. 2004 Apr-Jun;36(2):63-7
references.pmid: 15473046
references.citation: J Antimicrob Chemother. 2000 Apr;45(4):437-46
references.pmid: 10747819
references.citation: J Antimicrob Chemother. 2001 Jan;47(1):115-6
references.pmid: 11152443
references.citation: Chemotherapy. 1997 Jan-Feb;43(1):10-20
references.pmid: 8996736
references.citation: J Antimicrob Chemother. 2002 Jul;50(1):142-3
references.pmid: 12096024
references.citation: J Infect Dis. 1989 May;159(5):1003-4
references.pmid: 2708840
references.citation: Antimicrob Agents Chemother. 1998 Feb;42(2):257-62
references.pmid: 9527769
references.citation: Diagn Microbiol Infect Dis. 2002 Jun;43(2):157-62
references.pmid: 12088624
references.citation: Antimicrob Agents Chemother. 2001 Aug;45(8):2400-2
references.pmid: 11451709
references.citation: MMWR Recomm Rep. 1996 May 31;45(RR-7):1-24
references.pmid: 8637497
references.citation: Diagn Microbiol Infect Dis. 2006 Jan;54(1):79-82
references.pmid: 16368478
references.citation: Antimicrob Agents Chemother. 2003 Nov;47(11):3605-9
references.pmid: 14576126
references.citation: J Infect Dis. 1981 Jan;143(1):134
references.pmid: 7012243
references.citation: Enferm Infecc Microbiol Clin. 2007 Jan;25(1):67-8
references.pmid: 17261249
references.citation: Clin Microbiol Rev. 1998 Jul;11(3):497-513
references.pmid: 9665980
references.citation: Medicina (B Aires). 2005;65(3):201-6
references.pmid: 16042129
references.citation: Pediatrics. 1997 Mar;99(3):489-96
references.pmid: 9041310
references.citation: Infect Dis Obstet Gynecol. 2004;12(1):1-8
references.pmid: 15460188
references.citation: Clin Microbiol Infect. 2002 Nov;8(11):745-8
references.pmid: 12445014
references.citation: J Clin Microbiol. 2004 Mar;42(3):1263-4
references.pmid: 15004089