title: Placental mesenchymal dysplasia with hepatic mesenchymal hamartoma: a case report and literature review.
abstract: Placental mesenchymal dysplasia (PMD) is characterized by placentomegaly and grapelike vesicles resembling a partial molar pregnancy and in most cases, a phenotypically normal fetus. Hepatic mesenchymal hamartoma (HMH) is a benign hamartomatous proliferation of mesenchymal liver tissue. PMD has been associated with HMH. Although rare, in combination, it is known to carry a poorer prognosis than in fetuses without structural abnormalities. There are only a few reported cases of PMD and associated HMH with varying management strategies and outcomes, precluding ascertainment of the most appropriate treatment plan. We present a case of PMD with associated cystic HMH resulting in fetal death. We also reviewed the published literature on this issue and explored possible management strategies to prevent adverse fetal and neonatal outcomes.
authors.affiliation: 1Hofstra North Shore-LIJ School of Medicine, Maternal Fetal Medicine, North Shore University Hospital, Manhasset, NY, USA.
authors.forename: Kemoy
authors.initials: K
authors.lastname: Harris
authors.forename: Chrystalle Katte
authors.initials: CK
authors.lastname: Carreon
authors.forename: Nidhi
authors.initials: N
authors.lastname: Vohra
authors.forename: Alex
authors.initials: A
authors.lastname: Williamson
authors.forename: Stephen
authors.initials: S
authors.lastname: Dolgin
authors.forename: Burton
authors.initials: B
authors.lastname: Rochelson
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000473:pathology; D006222:Hamartoma / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D008648:Mesoderm / Q000000981:diagnostic imaging / Q000473:pathology; D010920:Placenta / Q000000981:diagnostic imaging / Q000473:pathology*; D011247:Pregnancy; D014463:Ultrasonography