title: Cadmium iodide-mediated allenylation of terminal alkynes with ketones.
abstract: Allenes are important building blocks in organic synthesis and have attracted much attention from researchers worldwide. So far, mono- and 1,3-disubstituted allenes can be prepared easily by applying the allenylation of terminal alkynes reaction of aldehydes. However, trisubstituted allenes have never been reported using this reaction due to the extremely low reactivity of ketones. Here, we report the one-pot synthesis of trisubstituted allenes from terminal alkynes and ketones utilizing cadmium iodide as the mediator. With this protocol, a series of different allenes, including 1,5-bisallenes and optically active allenols, which are especially important in synthetic chemistry, have been successfully prepared.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Tang
authors.forename: Can
authors.initials: C
authors.lastname: Zhu
authors.forename: Tao
authors.initials: T
authors.lastname: Cao
authors.forename: Jingqiang
authors.initials: J
authors.lastname: Kuang
authors.forename: Weilong
authors.initials: W
authors.lastname: Lin
authors.forename: Shengjun
authors.initials: S
authors.lastname: Ni
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Zhang
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma