title: Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention.
abstract: OBJECTIVE
  Calorie restriction and intermittent fasting are two dietary interventions that can improve aging. Religious fasting also suggested having similar benefit; however, such studies are still scarce. Thus, this study aimed to determine the effect of fasting calorie restriction (FCR) on metabolic parameters and DNA damage among healthy older adult men.
  
  
  METHODS
  A randomized controlled study was done on men, aged 50-70 years in Klang Valley, Malaysia. Subjects were divided into two groups; FCR (reduction of 300-500 kcal/d combined with 2 days/week of Muslim Sunnah Fasting) and control. Assessment was ascertained at three time point; baseline, weeks 6 and 12. Blood samples were analyzed for lipid profile, DNA damage and malondialdehyde (MDA).
  
  
  RESULTS
  The FCR group reduced their energy intake for approximately 18% upon completion of the study. A significant interaction effect was found in body weight, body mass index, fat percentage, fat mass, blood pressure, total cholesterol, low-density lipoprotein cholesterol and the ratio of total cholesterol/high-density lipoprotein cholesterol (p < 0.05). A significant improvement (p < 0.001) in total DNA rejoining cells and MDA (p < 0.05) was also observed in the FCR group.
  
  
  CONCLUSIONS
  FCR improved metabolic parameters and DNA damage in healthy older adult men. Therefore, there is a need to further examine the mechanism of FCR.
authors.affiliation: Dietetic Program .
authors.forename: Nur Islami Mohd Fahmi
authors.initials: NI
authors.lastname: Teng
authors.forename: Suzana
authors.initials: S
authors.lastname: Shahar
authors.forename: Nor Fadilah
authors.initials: NF
authors.lastname: Rajab
authors.forename: Zahara Abdul
authors.initials: ZA
authors.lastname: Manaf
authors.forename: Mohamad Hanapi
authors.initials: MH
authors.lastname: Johari
authors.forename: Wan Zurinah Wan
authors.initials: WZ
authors.lastname: Ngah
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D031204:Caloric Restriction / Q000379:methods*; D004249:DNA Damage; D005215:Fasting / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood*; D008296:Malaysia; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D016896:Treatment Outcome
chemical_list: D008075:Lipoproteins, HDL; D008315:Malondialdehyde