title: Association between TGF-β1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis.
abstract: BACKGROUND
  Associations between transforming growth factor (TGF)-β1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations.
  
  
  METHODS
  We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.
  
  
  RESULTS
  A total of 14 studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was significantly associated with HCC risk (OR=1.74, 95% CI: 1.22-2.47, p=0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR=1.40, 95% CI: 1.15-1.70, p=0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies.
  
  
  CONCLUSIONS
  Our meta-analysis suggested that the TGF-β1 +869C/T and -509C/T polymorphisms may be risk factors for developing HCC.
authors.affiliation: 1 Department of Radiology, College of Basic Medicine, Chongqing Medical University , Chongqing, People's Republic of China .
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunbao
authors.initials: C
authors.lastname: Zang
authors.forename: Yajun
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Liu
authors.forename: Lingyan
authors.initials: L
authors.lastname: Zhang
authors.forename: Shaolin
authors.initials: S
authors.lastname: Li
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1
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