title: QTL mapping of leukocyte telomere length in American Indians: the Strong Heart Family Study.
abstract: Telomeres play a central role in cellular senescence and are associated with a variety of age-related disorders such as dementia, Alzheimer's disease and atherosclerosis. Telomere length varies greatly among individuals of the same age, and is heritable. Here we performed a genome-wide linkage scan to identify quantitative trait loci (QTL) influencing leukocyte telomere length (LTL) measured by quantitative PCR in 3,665 American Indians (aged 14-93 years) from 94 large, multi-generational families. All participants were recruited by the Strong Heart Family Study (SHFS), a prospective study to identify genetic factors for cardiovascular disease and its risk factors in American Indians residing in Oklahoma, Arizona and Dakota. LTL heritability was estimated to be between 51% and 62%, suggesting a strong genetic predisposition to interindividual variation of LTL in this population. Significant QTLs were localized to chromosome 13 (Logarithm of odds score (LOD)=3.9) at 13q12.11, to 18q22.2 (LOD=3.2) and to 3p14.1 (LOD=3.0) for Oklahoma. This is the first study to identify susceptibility loci influencing leukocyte telomere variation in American Indians, a minority group suffering from a disproportionately high rate of type 2 diabetes and other age-related disorders.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA;
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.forename: V Saroja
authors.initials: VS
authors.lastname: Voruganti
authors.forename: Jue
authors.initials: J
authors.lastname: Lin
authors.forename: Tet
authors.initials: T
authors.lastname: Matsuguchi
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Blackburn
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.forename: Elisa T
authors.initials: ET
authors.lastname: Lee
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D002874:Chromosome Mapping; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D040641:Quantitative Trait Loci; D012307:Risk Factors; D059505:Telomere Homeostasis / Q000235:genetics*; D014481:United States; D055815:Young Adult
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