title: First chemical constituents from Cordia exaltata Lam and antimicrobial activity of two neolignans.
abstract: The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-D-glucopyranoside (4a), stigmasterol-3-O-β-D-glucopyranoside (4b), phaeophytin A (5), 13²-hydroxyphaeophytin A (6), 17³-ethoxypheophorbide A (7), 13²-hydroxy-17³-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4'-dimethoxyflavone (17), kaempherol 3-O-β-D-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-L-ramnopyranoside (19). Their structures were identified by ¹H and ¹³C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time.
authors.affiliation: Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil.
authors.forename: Tiago Bezerra
authors.initials: TB
authors.lastname: de Sá de Sousa Nogueira
authors.forename: Raquel Bezerra
authors.initials: RB
authors.lastname: de Sá de Sousa Nogueira
authors.forename: Davi Antas
authors.initials: DA
authors.lastname: E Silva
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
authors.forename: Edeltrudes
authors.initials: E
authors.lastname: de Oliveira Lima
authors.forename: Fillipe
authors.initials: F
authors.lastname: de Oliveira Pereira
authors.forename: Jéssica Karina
authors.initials: JK
authors.lastname: da Silva Maciel
authors.forename: Milen Maria Magalhães
authors.initials: MM
authors.lastname: de Souza Fernandes
authors.forename: Fernando Antônio
authors.initials: FA
authors.lastname: de Medeiros
authors.forename: Rosangela
authors.initials: R
authors.lastname: do Socorro Ferreira Rodrigues Sarquis
authors.forename: Raimundo Braz
authors.initials: RB
authors.lastname: Filho
authors.forename: Maria
authors.initials: M
authors.lastname: de Fátima Vanderlei de Souza
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D031213:Cordia / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017705:Lignans; D010936:Plant Extracts
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