title: Fluorinated graphene oxide; a new multimodal material for biological applications.
abstract: Fluorinated graphene oxide (FGO) is reported for the first time as a magnetically responsive drug carrier that can serve both as a magnetic resonance imaging (MRI) and photoacoustic contrast agent, under preclinical settings, and as a type of photothermal therapy. Its hydrophilic nature facilitates biocompatibility. FGO as a broad wavelength absorber, with high charge transfer and strong non-linear scattering is optimal for NIR laser-induced hyperthermia.
authors.affiliation: Department of Mechanical, Engineering & Materials Science, Rice University, 6100 Main St. Houston, TX, 77005, USA; Department of Translational Molecular Pathology, MD Anderson Cancer Center, 7435 Fannin Street, Houston, TX, 77054, USA.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Romero-Aburto
authors.forename: Tharangattu N
authors.initials: TN
authors.lastname: Narayanan
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasumura
authors.forename: Trevor M
authors.initials: TM
authors.lastname: Mitcham
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.forename: Paris J
authors.initials: PJ
authors.lastname: Cox
authors.forename: Richard R
authors.initials: RR
authors.lastname: Bouchard
authors.forename: Toru
authors.initials: T
authors.lastname: Maekawa
authors.forename: D Sakthi
authors.initials: DS
authors.lastname: Kumar
authors.forename: Suzy V
authors.initials: SV
authors.lastname: Torti
authors.forename: Sendurai A
authors.initials: SA
authors.lastname: Mani
authors.forename: Pulickel M
authors.initials: PM
authors.lastname: Ajayan
mesh_terms: D055011:Ablation Techniques; D006108:Graphite / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D054879:Halogenation; D006801:Humans; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D010087:Oxides / Q000737:chemistry*
chemical_list: D010087:Oxides; D006108:Graphite
keywords: drug delivery; magnetic resonance imaging (MRI); multifunctional graphene; photoacoustics; photothermal therapy
references.citation: Nano Res. 2008;1(3):203-212
references.pmid: 20216934
references.citation: ACS Nano. 2011 Jun 28;5(6):4987-96
references.pmid: 21574593
references.citation: J Am Chem Soc. 2011 May 4;133(17):6825-31
references.pmid: 21476500
references.citation: Nat Chem. 2010 Dec;2(12):1015-24
references.pmid: 21107364
references.citation: ACS Nano. 2010 Aug 24;4(8):4806-14
references.pmid: 20731455
references.citation: Nat Chem. 2009 Aug;1(5):403-8
references.pmid: 21378895
references.citation: Ultrasonics. 2002 May;40(1-8):117-22
references.pmid: 12159917
references.citation: Theranostics. 2012;2(3):283-94
references.pmid: 22448195
references.citation: Biomaterials. 2011 Sep;32(26):6155-63
references.pmid: 21632103
references.citation: Trends Biotechnol. 2011 May;29(5):205-12
references.pmid: 21397350
references.citation: Int J Nanomedicine. 2012;7:4679-95
references.pmid: 22956869
references.citation: Pharm Res. 2010 Jan;27(1):1-16
references.pmid: 19902338
references.citation: Nano Lett. 2012 Feb 8;12(2):844-9
references.pmid: 22216895
references.citation: ACS Nano. 2012 Mar 27;6(3):2731-40
references.pmid: 22376049
references.citation: Chem Commun (Camb). 2012 Jan 4;48(1):106-8
references.pmid: 22037540
references.citation: NMR Biomed. 2011 Feb;24(2):114-29
references.pmid: 20842758
references.citation: Chem Rev. 2012 Nov 14;112(11):6156-214
references.pmid: 23009634
references.citation: J Am Chem Soc. 2010 Jul 14;132(27):9274-6
references.pmid: 20565095
references.citation: J Am Coll Surg. 2004 Feb;198(2):190-7
references.pmid: 14759774
references.citation: Trends Biotechnol. 2006 Feb;24(2):62-7
references.pmid: 16380179
references.citation: Nanomedicine (Lond). 2011 Feb;6(2):317-24
references.pmid: 21385134
references.citation: Adv Mater. 2010 Apr 18;22(15):1736-40
references.pmid: 20496406
references.citation: Nat Mater. 2007 Sep;6(9):652-5
references.pmid: 17660825
references.citation: Adv Mater. 2012 Jun 12;24(22):2992-8
references.pmid: 22573478
references.citation: ACS Nano. 2011 Sep 27;5(9):7000-9
references.pmid: 21815655
references.citation: Theranostics. 2012;2(3):235-7
references.pmid: 22448193
references.citation: Acc Chem Res. 2011 Oct 18;44(10):947-56
references.pmid: 21848277
references.citation: Biomaterials. 2011 Sep;32(26):6316-23
references.pmid: 21636128
references.citation: J Phys Chem C Nanomater Interfaces. 2007 Apr 6;111(17):6245-6251
references.pmid: 20165552
references.citation: Biomaterials. 2012 Mar;33(8):2532-45
references.pmid: 22206596
references.citation: Biomaterials. 2011 Nov;32(33):8555-61
references.pmid: 21839507
references.citation: Biomaterials. 2011 Oct;32(29):7127-38
references.pmid: 21724249
references.citation: ACS Nano. 2010 Feb 23;4(2):1033-41
references.pmid: 20121065
references.citation: Nano Lett. 2007 Jul;7(7):1929-34
references.pmid: 17550297
references.citation: J Am Chem Soc. 2008 Aug 20;130(33):10876-7
references.pmid: 18661992
references.citation: Nano Lett. 2010 Sep 8;10(9):3318-23
references.pmid: 20684528
references.citation: Acc Chem Res. 2011 Oct 18;44(10):914-24
references.pmid: 21528889