title: Primary aldosteronism with concurrent primary hyperparathyroidism in a patient with arrhythmic disorders.
abstract: A 25-year-old Caucasian woman was admitted to our department with severe hypokalemia that was associated with hypercalcemia. An endocrinological investigation showed the coexistence of primary hyperparathyroidism (PHPT) and primary aldosteronism (PA), arising from an adenoma of the left cortical adrenal gland. The patient underwent left laparoscopic adrenalectomy, but refused the surgical neck exploration that would be required for parathyroidectomy. The post-operative course was uneventful, and the patient realized a normalization of her potassium serum level and a reduction of her blood pressure values. We herein report the important issues regarding the management of a severe electrolyte imbalance, in view of the reciprocal interaction between aldosterone and parathyroid hormone, and their combined potential for causing cardiovascular damage.
authors.affiliation: Secondary Arterial Hypertension Unit, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Petramala
authors.forename: Claudio
authors.initials: C
authors.lastname: Savoriti
authors.forename: Laura
authors.initials: L
authors.lastname: Zinnamosca
authors.forename: Cristiano
authors.initials: C
authors.lastname: Marinelli
authors.forename: Amina
authors.initials: A
authors.lastname: Settevendemmie
authors.forename: Camilla
authors.initials: C
authors.lastname: Calvieri
authors.forename: Marco
authors.initials: M
authors.lastname: Catani
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D018246:Adrenocortical Adenoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000503:physiopathology; D004562:Electrocardiography; D015736:Felodipine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D011189:Potassium Chloride / Q000008:administration & dosage; D019275:Radiopharmaceuticals; D013148:Spironolactone / Q000008:administration & dosage; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D013148:Spironolactone; D011189:Potassium Chloride; D017256:Technetium Tc 99m Sestamibi; D015736:Felodipine