title: Meningococcemia due to the 2000 Hajj-associated outbreak strain (Serogroup W-135 ST-11) with immunoreactive complications.
abstract: We present the first reported case of systemic infection with Neisseria meningitidis serogroup W-135 sequence type (ST)-11 in Japan. A 44-year-old woman presented with high fever, sore throat, and fatigue and was diagnosed with N. meningitidis bacteremia. The causative strain was identified as serogroup W-135 ST-11 by polymerase chain reaction and multilocus sequence typing. Approximately 1 month after treatment, she developed high fever, dyspnea, chest pain, and shoulder pain due to pericarditis, polyarthritis, and tenosynovitis, which are all relatively common immunoreactive complications of W-135 ST-11 meningococcal infections. This causative strain was the same as that responsible for an outbreak of meningitis among Hajj pilgrims in 2000. The strain is now found worldwide because it can attain a high carriage rate and has a long duration of carriage. We suspect that our patient's infection was acquired from an imported chronic carrier.
authors.affiliation: Travel Clinic, Disease Control and Prevention Center, National Center for Global Health and Medicine.
authors.forename: Kei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Takuma
authors.initials: T
authors.lastname: Shindo
authors.forename: Mugen
authors.initials: M
authors.lastname: Ujiie
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kanagawa
authors.forename: Junwa
authors.initials: J
authors.lastname: Kunimatsu
authors.forename: Yuiichi
authors.initials: Y
authors.lastname: Tamori
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kano
authors.forename: Rumi
authors.initials: R
authors.lastname: Okuno
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Norio
authors.initials: N
authors.lastname: Ohmagari
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology* / Q000473:pathology; D007564:Japan; D008589:Meningococcal Infections / Q000150:complications* / Q000382:microbiology*; D058885:Multilocus Sequence Typing; D038582:Neisseria meningitidis, Serogroup W-135 / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D012703:Serotyping