title: Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.
abstract: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correlation with IL-6, IL-10 and TNFα, we compared 20 MS individuals with 27 healthy controls. In MS, a decrease in PACAP-38 in CSF and a decrease in plasma IL-6 concentration were seen. A positive correlation between plasma VIP and plasma IL-6 was identified. We conclude that VIP and PACAP may influence the course of MS.
authors.affiliation: Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, Ceglowska 80, 01-809 Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Baranowska-Bik
authors.forename: Jan
authors.initials: J
authors.lastname: Kochanowski
authors.forename: Dorota
authors.initials: D
authors.lastname: Uchman
authors.forename: Ewa
authors.initials: E
authors.lastname: Wolinska-Witort
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kalisz
authors.forename: Lidia
authors.initials: L
authors.lastname: Martynska
authors.forename: Boguslawa
authors.initials: B
authors.lastname: Baranowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Bik
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000097:blood / Q000134:cerebrospinal fluid / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000134:cerebrospinal fluid / Q000502:physiology*
chemical_list: C495401:ADCYAP1 protein, human; D015415:Biomarkers; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014660:Vasoactive Intestinal Peptide
keywords: IL-10; IL-6; Multiple sclerosis; PACAP; TNFα; VIP