title: Functional genomic analyses of the gut microbiota for CRC screening.
abstract: The evidence for a strong correlation between the gut microbiota and colorectal carcinogenesis is quickly gathering pace. This correlation raises important questions, such as whether analysis of the microbiota can be used for screening purposes, and whether targeted intervention can influence the risk of development and progression of neoplasia. The recovery of several pathobionts-such as members of the different bacterial phyla Proteobacteria, Bacteroidetes and Fusobacteria-from the tumour microenvironment of patients with colorectal cancer (CRC) now provides a link between specific microbial colonization and cancer. However, other intestinal bacteria belonging to another major intestinal phylum, Firmicutes, might be effective in the treatment of pathogenic inflammation related to CRC. Future approaches based on the analysis of the gut microbiota of patients with CRC combined with large human cohort studies might open up new possibilities for further prophylactic, screening and treatment strategies.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Gravendijkwal 230, NL3015 CE Rotterdam, Netherlands.
authors.forename: Sergey R
authors.initials: SR
authors.lastname: Konstantinov
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: Maikel P
authors.initials: MP
authors.lastname: Peppelenbosch
mesh_terms: D001419:Bacteria; D015179:Colorectal Neoplasms; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology; D023281:Genomics; D006801:Humans; D007422:Intestines / Q000382:microbiology; D064307:Microbiota
references.citation: Microb Biotechnol. 2011 May;4(3):368-74
references.pmid: 21375696
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2108-13
references.pmid: 22308390
references.citation: Genome Res. 2012 Feb;22(2):299-306
references.pmid: 22009989
references.citation: Am J Pathol. 2002 Jun;160(6):2253-7
references.pmid: 12057927
references.citation: Cancer Res. 2009 Jul 1;69(13):5490-7
references.pmid: 19570783
references.citation: Nutr Cancer. 2012 Aug;64(6):871-8
references.pmid: 22830611
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9
references.pmid: 20566854
references.citation: Science. 2011 Jan 21;331(6015):337-41
references.pmid: 21205640
references.citation: Br J Nutr. 2012 Jun;107(11):1623-34
references.pmid: 21992995
references.citation: Inflamm Bowel Dis. 2011 Sep;17(9):1971-8
references.pmid: 21830275
references.citation: Genome Res. 2012 Feb;22(2):292-8
references.pmid: 22009990
references.citation: Immunol Rev. 2012 Jan;245(1):13-26
references.pmid: 22168411
references.citation: J Proteome Res. 2012 Dec 7;11(12):5573-85
references.pmid: 23116228
references.citation: J Clin Invest. 2011 Jun;121(6):2242-53
references.pmid: 21606592
references.citation: Nature. 2012 Nov 8;491(7423):254-8
references.pmid: 23034650
references.citation: J Am Coll Surg. 2012 Apr;214(4):390-8; discussion 398-9
references.pmid: 22289517
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19474-9
references.pmid: 19047644
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
references.pmid: 18936492
references.citation: Gut. 2011 Aug;60(8):1050-9
references.pmid: 21471573
references.citation: Gastroenterology. 2007 Feb;132(2):562-75
references.pmid: 17258729
references.citation: Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G1025-34
references.pmid: 18787064
references.citation: Gastroenterology. 2012 Aug;143(2):382-9
references.pmid: 22609382
references.citation: Trends Mol Med. 2011 Oct;17(10):564-72
references.pmid: 21724466
references.citation: Nature. 2012 Oct 4;490(7418):55-60
references.pmid: 23023125
references.citation: Gastroenterology. 2011 Jul;141(1):227-36
references.pmid: 21621540
references.citation: Clin Microbiol Rev. 2006 Jul;19(3):449-90
references.pmid: 16847081
references.citation: Nat Rev Immunol. 2012 Oct;12(10):728-34
references.pmid: 23007572
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4623-30
references.pmid: 21282652
references.citation: Inflamm Bowel Dis. 2013 Mar;19(3):481-8
references.pmid: 23385241
references.citation: Science. 2012 Jun 8;336(6086):1268-73
references.pmid: 22674334
references.citation: Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7
references.pmid: 22689992
references.citation: Am J Clin Nutr. 2013 Jul;98(1):111-20
references.pmid: 23719549
references.citation: Gastroenterology. 2004 Aug;127(2):412-21
references.pmid: 15300573
references.citation: Nutr Rev. 2012 Aug;70 Suppl 1:S45-56
references.pmid: 22861807
references.citation: Infect Immun. 2011 Jul;79(7):2597-607
references.pmid: 21536792
references.citation: Am J Clin Nutr. 2007 Feb;85(2):488-96
references.pmid: 17284748
references.citation: Gastroenterology. 2012 Mar;142(3):543-551.e7
references.pmid: 22108198
references.citation: Science. 2012 Oct 5;338(6103):120-3
references.pmid: 22903521
references.citation: Gut. 2012 Jul;61(7):1007-15
references.pmid: 22301383
references.citation: Gastroenterology. 2004 Jul;127(1):80-93
references.pmid: 15236175
references.citation: Curr Biol. 2012 Sep 11;22(17):R733-40
references.pmid: 22975004
references.citation: Nature. 2013 Jun 6;498(7452):99-103
references.pmid: 23719380
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10321-6
references.pmid: 15985548
references.citation: J Biol Chem. 2006 Jun 23;281(25):17246-17252
references.pmid: 16627467
references.citation: Nature. 2013 Jan 3;493(7430):45-50
references.pmid: 23222524