title: Cryptogenia multifocal ulcerous stenosing enteritis: an entity on its own as a cause of abdominal pain, iron deficiency anemia and protein-losing enteropathy.
abstract: We studied a patient with edema secondary to protein losing enteropathy, and recurrent bouts of bloating and abdominal pain secondary to intestinal subocclusion episodes. After the clinical study, the patient was diagnosed of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE), that is a rare disease, probably caused by mutations in the gene PLA2G4A, and characterized by multiple short stenosis of the small bowel with superficial ulcers, which do not exceed the submucosa layer. Inflammatory bowel disease (Chron's disease), intestinal tuberculosis and intestinal ulcers secondary to non-steroidal anti-inflammatory drugs are the main differential diagnosis. To sum up, physicians should included CMUSE in the differential diagnosis of recurrent abdominal pain, iron deficiency anaemia, occult intestinal bleeding, edema and protein losing enteropathy.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: pablogvasco@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Guisado Vasco
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: G
authors.initials: G
authors.lastname: Fraile Rodríguez
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000209:etiology; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004751:Enteritis / Q000175:diagnosis*; D006801:Humans; D007415:Intestinal Obstruction; D007421:Intestine, Small; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000175:diagnosis*; D014456:Ulcer / Q000175:diagnosis*
keywords: Abdominal pain; Cryptogenic multifocal ulcerous stenosing enteritis; Dolor abdominal; Enteritis ulcerosa criptogénica estenosante y multifocal; Enteropatía pierde proteínas; Gastrointestinal bleeding of obscure origin; Protein-losing enteropathy; Pérdida de peso; Sangrado digestivo de causa oculta; Weight loss