title: The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25 kg/m(2): one year follow-up.
abstract: OBJECTIVE
  The goals of this study are to evaluate the effect of duodenojejunal bypass (DJB) for type 2 diabetes mellitus (T2DM) patients below body mass index (BMI) 25 kg/m(2) in one year follow-up, and to compare the results of 1 week which we have reported in 2011.
  
  
  METHODS
  In this prospective observational study, there were 31 type 2 diabetic patients who underwent DJB at Inha University Hospital from July 2009 to January 2011. We did laboratories such as 75-g oral glucose tolerance test (OGTT), insulin level and hemoglobin A1c (HbA1c), etc. and compared their changes of preoperative, a week, 3 months, and 12 months.
  
  
  RESULTS
  Mean BMI was 23.1 ± 1.3 kg/m(2), mean duration of T2DM was 8.3 ± 4.7 and mean age was 46.6 ± 7.7 years. There were a significant decrease of 75-g OGTT levels and increase of insulin secretion after 3 months. 13.3% showed diabetic remission (HbA1c < 6.0, medication cessation) and 26.7% showed diabetic improvement. The rates of remission and improvement much declined comparing with that of postoperative 1 week although those were determined by fasting and postprandial 2 hour level of glucose.
  
  
  CONCLUSIONS
  This is the first study of metabolic surgery in Korean diabetes patients in the healthy weight range. DJB exerted positive influences on insulin resistance as well as beta cell function. Early effects on T2DM after DJB could be estimated as one of good modalities, although the effectiveness seems to be unacceptable. Further studies are mandatory for evaluation of the effectiveness of metabolic surgery and finding prognostic factors.
authors.affiliation: Department of Surgery, Inha University School of Medicine, Incheon, Korea.
authors.forename: Yoonseok
authors.initials: Y
authors.lastname: Heo
authors.forename: Jong-Hyuk
authors.initials: JH
authors.lastname: Ahn
authors.forename: Seok-Hwan
authors.initials: SH
authors.lastname: Shin
authors.forename: Yeon-Ji
authors.initials: YJ
authors.lastname: Lee
keywords: Duodenojejunal bypass; Metabolic surgery; Type 2 diabetes mellitus
references.citation: Obes Surg. 2008 Feb;18(2):179-81
references.pmid: 18176858
references.citation: Ann Surg. 2004 Jan;239(1):1-11
references.pmid: 14685093
references.citation: J Clin Endocrinol Metab. 2008 Jul;93(7):2479-85
references.pmid: 18430778
references.citation: J Korean Surg Soc. 2012 Jun;82(6):347-55
references.pmid: 22708096
references.citation: Ann Surg. 1995 Sep;222(3):339-50; discussion 350-2
references.pmid: 7677463
references.citation: N Engl J Med. 2004 Dec 23;351(26):2683-93
references.pmid: 15616203
references.citation: Ann Surg. 2012 Jul;256(1):72-8
references.pmid: 22664560
references.citation: Ann Surg. 2006 Nov;244(5):741-9
references.pmid: 17060767
references.citation: Surg Obes Relat Dis. 2006 Jan-Feb;2(1):48-51; discussion 51
references.pmid: 16925317
references.citation: Ann Surg. 1987 Sep;206(3):316-23
references.pmid: 3632094
references.citation: J Clin Invest. 2006 Jul;116(7):1802-12
references.pmid: 16823478
references.citation: Surg Obes Relat Dis. 2006 May-Jun;2(3):401-4, discussion 404
references.pmid: 16925363
references.citation: Arch Surg. 2004 Oct;139(10):1088-92
references.pmid: 15492149
references.citation: Ann Surg. 1992 Jun;215(6):633-42; discussion 643
references.pmid: 1632685
references.citation: Obes Surg. 2004 Jun-Jul;14(6):840-8
references.pmid: 15318993
references.citation: Gastroenterology. 2002 Feb;122(2):531-44
references.pmid: 11832466
references.citation: Nutr Hosp. 2012 Mar-Apr;27(2):623-31
references.pmid: 22732993
references.citation: N Engl J Med. 1992 May 14;326(20):1316-22
references.pmid: 1348845
references.citation: Diabetes Metab. 2005 Jun;31(3 Pt 1):233-42
references.pmid: 16142014
references.citation: JAMA. 2002 Jan 16;287(3):360-72
references.pmid: 11790216
references.citation: Diabetes. 2006 Jul;55(7):2025-31
references.pmid: 16804072
references.citation: Diabetes Care. 2009 Mar;32(3):375-80
references.pmid: 19033407