title: Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists.
abstract: An understanding of the diagnosis and clinical management of hereditary breast and ovarian cancer syndrome (HBOC) is essential for obstetricians/gynecologists. This article provides practical information regarding collecting a family history, cancer risk assessment and genetic testing, BRCA-associated cancer prognosis and treatment, screening recommendations, and prevention strategies. Through appropriate cancer risk assessment, women with BRCA1/2 mutations can be identified, and screening and prevention strategies can be used before a diagnosis of cancer occurs. Women's health providers with a strong working knowledge of HBOC are able to improve the quality of care for women and families impacted by BRCA1/2 mutations.
authors.affiliation: Department of Gynecology and Obstetrics, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303, USA. Electronic address: dmeaney@emory.edu.
authors.forename: Dana
authors.initials: D
authors.lastname: Meaney-Delman
authors.forename: Cecelia A
authors.initials: CA
authors.lastname: Bellcross
mesh_terms: D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D005260:Female; D006176:Gynecology; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D009774:Obstetrics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D017410:Practice Guidelines as Topic; D018570:Risk Assessment
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human
keywords: BRCA1; BRCA2; Clinical management; Genetic testing; Hereditary breast cancer; Hereditary ovarian cancer