title: Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.
abstract: Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas.
  
  
  RESULTS
  Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas.
authors.affiliation: Department of Orthopaedic Surgery, Chonbuk National University Medical School, Research Institute of Clinical Medicine and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea.
authors.forename: Jung Ryul
authors.initials: JR
authors.lastname: Kim
authors.forename: Young Jae
authors.initials: YJ
authors.lastname: Moon
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Kwon
authors.forename: Jun Sang
authors.initials: JS
authors.lastname: Bae
authors.forename: Sajeev
authors.initials: S
authors.lastname: Wagle
authors.forename: Taek Kyun
authors.initials: TK
authors.lastname: Yu
authors.forename: Kyoung Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Park
authors.forename: Ju-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Moon
authors.forename: Ho
authors.initials: H
authors.lastname: Lee
authors.forename: Myoung Ja
authors.initials: MJ
authors.lastname: Chung
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012509:Sarcoma / Q000235:genetics / Q000473:pathology*; D056564:Sirtuin 1 / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C527450:CCAR2 protein, human; C447939:SIRT1 protein, human; D056564:Sirtuin 1
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