title: Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation.
abstract: Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
authors.forename: Qiming
authors.initials: Q
authors.lastname: Liang
authors.forename: Brian
authors.initials: B
authors.lastname: Chang
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Brulois
authors.forename: Kamilah
authors.initials: K
authors.lastname: Castro
authors.forename: Chan-Ki
authors.initials: CK
authors.lastname: Min
authors.forename: Mary A
authors.initials: MA
authors.lastname: Rodgers
authors.forename: Mude
authors.initials: M
authors.lastname: Shi
authors.forename: Jianning
authors.initials: J
authors.lastname: Ge
authors.forename: Pinghui
authors.initials: P
authors.lastname: Feng
authors.forename: Byung-Ha
authors.initials: BH
authors.lastname: Oh
authors.forename: Jae U
authors.initials: JU
authors.lastname: Jung
mesh_terms: D001343:Autophagy; D000071183:Autophagy-Related Proteins; D006367:HeLa Cells; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D015151:Immunoblotting; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D000071183:Autophagy-Related Proteins; D047908:Intracellular Signaling Peptides and Proteins; C468524:K7 protein, Human herpesvirus 8; D024101:Mitochondrial Proteins; C552537:RUBCN protein, human; D014764:Viral Proteins
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