title: Hypermethylation of HOXA10 gene in mid-luteal endometrium from women with ovarian endometriomas.
abstract: A decrease in HOXA10 gene expression in eutopic mid-secretory endometrium has been found in women with endometriosis-associated infertility. Promoter hypermethylation of HOXA10 is thought to be the leading mechanism for epigenetic gene regulation in patients with endometriosis. In our series we documented significantly higher HOXA10 promoter methylation levels in women with ovarian endometriomas than in healthy controls during the mid-luteal phase. Development of epigenetic-based strategies for non-surgical treatment of infertility related to ovarian endometriomas could be an attractive field of research in the coming years.
authors.affiliation: Department of Biomedical, Experimental and Clinical Sciences, Gynecology and Obstetrics Unit, University of Florence, Florence, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fambrini
authors.forename: Flavia
authors.initials: F
authors.lastname: Sorbi
authors.forename: Cecilia
authors.initials: C
authors.lastname: Bussani
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cioni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sisti
authors.forename: Karin L
authors.initials: KL
authors.lastname: Andersson
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019175:DNA Methylation; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005260:Female; D005786:Gene Expression Regulation; D005801:Genes, Homeobox / Q000235:genetics*; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000378:metabolism; D008183:Luteal Phase / Q000235:genetics* / Q000378:metabolism; D011446:Prospective Studies; D017422:Sequence Analysis, DNA
chemical_list: D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins; C069634:HOXA10 protein, human
keywords: Endometriosis; HOXA10 gene; epigenetic; infertility; methylation; ovarian cyst