title: Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.
abstract: Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus-1 (Del-1). In summary, CHD was associated with distinct changes in circulating miRNA transport and these changes may contribute to the abnormal intercellular communication that underlies CHD initiation and progression.
authors.affiliation: Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Nnenna A
authors.initials: NA
authors.lastname: Finn
authors.forename: Danny
authors.initials: D
authors.lastname: Eapen
authors.forename: Pankaj
authors.initials: P
authors.lastname: Manocha
authors.forename: Hatem
authors.initials: H
authors.lastname: Al Kassem
authors.forename: Bernard
authors.initials: B
authors.lastname: Lassegue
authors.forename: Nima
authors.initials: N
authors.lastname: Ghasemzadeh
authors.forename: Arshed
authors.initials: A
authors.lastname: Quyyumi
authors.forename: Charles D
authors.initials: CD
authors.lastname: Searles
mesh_terms: D000293:Adolescent; D000328:Adult; D001665:Binding Sites; D001692:Biological Transport / Q000502:physiology; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D015815:Cell Adhesion Molecules; D002450:Cell Communication; D003327:Coronary Disease / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C110183:EDIL3 protein, human; D035683:MicroRNAs
keywords: AP; Atherosclerosis; CHD; Coronary heart disease; Del-1; Developmental endothelial locus-1; Exo; Intercellular signaling; LP; MP/MPs; MicroRNA; Microparticles; RF; aggregated protein; coronary heart disease; developmental endothelial locus-1; exosomes; lipoprotein; microparticles; risk factor
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