title: Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells.
abstract: It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs.
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Room 3310, Norman, OK 73019-5300 (USA).
authors.forename: Naveen
authors.initials: N
authors.lastname: Gandra
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D002470:Cell Survival; D018014:Gene Transfer Techniques; D008280:Magnetics / Q000379:methods*; D045164:Mesenchymal Stem Cell Transplantation; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D014162:Transfection; D014780:Viruses / Q000737:chemistry* / Q000235:genetics*
chemical_list: D012822:Silicon Dioxide
keywords: gene delivery; nanoparticles; phage display; stem cells; virus mimetics
references.citation: J Am Chem Soc. 2006 Feb 1;128(4):1078-9
references.pmid: 16433515
references.citation: J Neurosci Res. 2000 Aug 15;61(4):364-70
references.pmid: 10931522
references.citation: Arch Biochem Biophys. 1959 May;82(1):70-7
references.pmid: 13650640
references.citation: J Biomed Biotechnol. 2010;2010:735349
references.pmid: 20625411
references.citation: Nat Med. 2001 Apr;7(4):430-6
references.pmid: 11283669
references.citation: Small. 2013 Jan 28;9(2):215-21
references.pmid: 23047655
references.citation: Adv Drug Deliv Rev. 2006 Jul 7;58(4):467-86
references.pmid: 16781003
references.citation: Nat Biotechnol. 2002 Oct;20(10):1006-10
references.pmid: 12244328
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2509-14
references.pmid: 9482916
references.citation: Biomaterials. 2008 May;29(15):2415-22
references.pmid: 18295879
references.citation: Biomaterials. 2010 Aug;31(24):6279-308
references.pmid: 20493521
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2199-204
references.pmid: 11854516
references.citation: Mol Pharm. 2010 Oct 4;7(5):1629-42
references.pmid: 20735141
references.citation: J Control Release. 2006 Nov 28;116(2):255-64
references.pmid: 16914222
references.citation: Biomaterials. 2005 Mar;26(7):729-38
references.pmid: 15350777
references.citation: Stem Cells Dev. 2006 Feb;15(1):87-96
references.pmid: 16522166
references.citation: J Mol Biol. 1966 Nov 14;21(2):281-92
references.pmid: 4291403
references.citation: Science. 1996 Apr 12;272(5259):263-7
references.pmid: 8602510
references.citation: Biomaterials. 2003 Mar;24(7):1255-64
references.pmid: 12527266
references.citation: Gene Ther. 2006 Feb;13(4):283-7
references.pmid: 16462855
references.citation: Chem Biol. 2004 Nov;11(11):1553-9
references.pmid: 15556006
references.citation: Adv Funct Mater. 2013 Mar 6;23(9):1172-1181
references.pmid: 23885226
references.citation: J Control Release. 2011 May 30;152(1):2-12
references.pmid: 21295087
references.citation: Int J Pharm. 2002 Sep 5;244(1-2):105-15
references.pmid: 12204570
references.citation: J Control Release. 2007 Jul 31;120(3):233-41
references.pmid: 17582640
references.citation: Adv Drug Deliv Rev. 2001 Apr 25;47(2-3):277-94
references.pmid: 11311996