title: Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability.
abstract: Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing-remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM (P=0.042) and deep gray matter (P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Paling
authors.affiliation: Department of Radiology and Radiotherapy E01.132, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Esben
authors.initials: E
authors.lastname: Thade Petersen
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Tozer
authors.affiliation: 1] Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK [2] Medical Statistics Department, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Altmann
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: Claudia A M
authors.initials: CA
authors.lastname: Wheeler-Kingshott
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: Raju
authors.initials: R
authors.lastname: Kapoor
authors.affiliation: Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: David H
authors.initials: DH
authors.lastname: Miller
authors.affiliation: Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square MS Centre, London, UK.
authors.forename: Xavier
authors.initials: X
authors.lastname: Golay
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology*; D013113:Spin Labels; D013997:Time Factors; D055815:Young Adult
chemical_list: D013113:Spin Labels
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