title: [The effect of aluminum adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine].
abstract: OBJECTIVE
  To study the effect of aluminume adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine.
  
  
  METHODS
  Four batches of Sabin IPV were produced by different concentrations of type 1, 2, and 3 poliovirus and administrated on three-dose schedule at 0, 1, 2 months and 0, 2, 4 months on rats. Serum samples were collected one month after each dose and neutralizing antibody titers against three types poliovirus were determined by micro-neutralization assay.
  
  
  RESULTS
  The GMTs of neutralizing antibodies against three types poliovirus increased significantly and the seropositivity rates were 100% in all groups after 3 doses. There was no significant difference between two immunization schedules, and the 0, 2, 4 month schedule could induce higher level neutralizing antibody compared to the 0, 1, 2 month schedule. The groups with aluminum adjuvant could induce higher level neutralizing antibody compared to the groups without adjuvant.
  
  
  CONCLUSIONS
  Aluminum djuvant and immunization schedule could improve the immunogenicity of Sabin IPV.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan Key Laboraory of Vaccine Research & Development on Severe Infectious Diseases, Kunming 650118, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Xie
authors.forename: Han
authors.initials: H
authors.lastname: Cao
authors.forename: Shao-Yong
authors.initials: SY
authors.lastname: Tong
authors.forename: Jun-Rong
authors.initials: JR
authors.lastname: Wang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Tang
authors.forename: Jing-Ran
authors.initials: JR
authors.lastname: Yang
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Sun
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D007115:Immunization Schedule; D008297:Male; D011055:Poliovirus Vaccine, Oral / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral; D000536:Aluminum Hydroxide