title: Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse.
abstract: Hypercholesterolemia is a risk factor for the development of hypertrophic cardiomyopathy. Nevertheless, there are few studies aimed at determining the effects of dietary compounds on early or mild cardiac hypertrophy associated with dyslipidemia. Here we describe left ventricular (LV) hypertrophy in 12 week-old Apo E(-/-) hypercholesterolemic mice. The LV end diastolic posterior wall thickness and overall LV mass were significantly increased in Apo E(-/-) mice compared with wild type (WT) controls. Fractional shortening, LV end diastolic diameter, and hemodynamic parameters were unchanged from WT mice. Oral low dose quercetin (QCN; 0.1 µmol QCN/kg body weight for 6 weeks) significantly reduced total cholesterol and very low density lipoprotein in the plasma of Apo E(-/-) mice. QCN treatment also significantly decreased LV posterior wall thickness and LV mass in Apo E(-/-) mice. Myocardial geometry and function were unaffected in WT mice by QCN treatment. These data suggest that dietary polyphenolic compounds such as QCN may be effective modulators of plasma cholesterol and could prevent maladaptive myocardial remodeling.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-2180 USA ; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294-2180 USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Ulasova
authors.forename: Jessica
authors.initials: J
authors.lastname: Perez
authors.forename: Bradford G
authors.initials: BG
authors.lastname: Hill
authors.forename: Wayne E
authors.initials: WE
authors.lastname: Bradley
authors.forename: David W
authors.initials: DW
authors.lastname: Garber
authors.forename: Aimee
authors.initials: A
authors.lastname: Landar
authors.forename: Stephen
authors.initials: S
authors.lastname: Barnes
authors.forename: Jeevan
authors.initials: J
authors.lastname: Prasain
authors.forename: Dale A
authors.initials: DA
authors.lastname: Parks
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Dell'Italia
authors.forename: Victor M
authors.initials: VM
authors.lastname: Darley-Usmar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000235:genetics / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011794:Quercetin / Q000008:administration & dosage* / Q000627:therapeutic use; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001057:Apolipoproteins E; D002784:Cholesterol; D011794:Quercetin
keywords: Atherosclerosis; Cholesterol; Hypertrophy; Quercetin
references.citation: Atherosclerosis. 2005 Apr;179(2):247-54
references.pmid: 15777538
references.citation: Arterioscler Thromb Vasc Biol. 1999 Nov;19(11):2762-8
references.pmid: 10559023
references.citation: Free Radic Biol Med. 2002 Jun 1;32(11):1220-8
references.pmid: 12031906
references.citation: BMJ. 2006 Apr 15;332(7546):878-82
references.pmid: 16510492
references.citation: Nutrition. 2011 Jun;27(6):617-23
references.pmid: 21367579
references.citation: J Hypertens. 2006 Jan;24(1):75-84
references.pmid: 16331104
references.citation: J Lipid Res. 2000 Nov;41(11):1858-71
references.pmid: 11060356
references.citation: Biochem Biophys Res Commun. 2005 Sep 23;335(2):603-8
references.pmid: 16087165
references.citation: Circulation. 2001 Feb 13;103(6):836-41
references.pmid: 11171792
references.citation: Electrophoresis. 2001 May;22(8):1573-8
references.pmid: 11386672
references.citation: Br J Pharmacol. 2001 May;133(1):117-24
references.pmid: 11325801
references.citation: Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):749-57
references.pmid: 20093625
references.citation: J Cardiovasc Pharmacol. 2006 Apr;47(4):531-41
references.pmid: 16680066
references.citation: Cell. 1992 Oct 16;71(2):343-53
references.pmid: 1423598
references.citation: Cardiovasc Drugs Ther. 2012 Apr;26(2):109-20
references.pmid: 22183794
references.citation: Biochem Pharmacol. 2012 Jan 1;83(1):6-15
references.pmid: 21856292
references.citation: Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2138-43
references.pmid: 17488730
references.citation: Nutr Metab Cardiovasc Dis. 2001 Oct;11(5):312-9
references.pmid: 11887428
references.citation: Free Radic Res. 2005 Feb;39(2):185-94
references.pmid: 15763966
references.citation: Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H428-34
references.pmid: 10666072
references.citation: J Lipid Res. 2000 Jun;41(6):1020-6
references.pmid: 10828095
references.citation: Mol Nutr Food Res. 2012 Nov;56(11):1605-16
references.pmid: 22996837
references.citation: Biochemistry. 1998 Sep 29;37(39):13720-7
references.pmid: 9753460
references.citation: J Nutr. 2003 Jul;133(7):2268-72
references.pmid: 12840191
references.citation: Acta Pharmacol Sin. 2001 Dec;22(12):1103-6
references.pmid: 11749808
references.citation: J Biol Chem. 1999 Dec 10;274(50):35711-8
references.pmid: 10585451
references.citation: Can J Physiol Pharmacol. 2009 Sep;87(9):720-8
references.pmid: 19794523
references.citation: J Nutr. 2008 Apr;138(4):725-31
references.pmid: 18356327
references.citation: J Pharmacol Exp Ther. 2012 Nov;343(2):296-306
references.pmid: 22869926
references.citation: Curr Opin Lipidol. 2005 Feb;16(1):77-84
references.pmid: 15650567
references.citation: Int J Clin Pharmacol Res. 2000;20(3-4):49-54
references.pmid: 11314237
references.citation: Lipids. 2000 Sep;35(9):991-9
references.pmid: 11026620
references.citation: J Nutr. 2000 Sep;130(9):2243-50
references.pmid: 10958819
references.citation: J Lipid Res. 2000 Oct;41(10):1673-9
references.pmid: 11013310
references.citation: FEBS Lett. 1998 Apr 24;426(3):331-6
references.pmid: 9600261
references.citation: Mol Cell Biochem. 2005 Feb;270(1-2):147-55
references.pmid: 15792364
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):239-44
references.pmid: 14663554
references.citation: J Vasc Res. 2005 Nov-Dec;42(6):475-82
references.pmid: 16155363