title: Influence of ethnicity and improved outcome of acute myeloid leukaemia: two decades of follow-up of Israeli patient cohort.
abstract: Acute myeloid leukaemia is a disease with unfavourable prognosis. The significance of various prognostic parameters is not fully understood. We studied 293 patients to examine the influence of ethnicity and molecular markers. The median survival for all patients was correlated with age, white blood cell count and karyotype, and marginally with FLT3 internal tandem duplication. Arab patients were younger than Jewish patients; however, their survival was poorer albeit being treated with the same protocols and having more favourable cytogenetics. Survival rates improved over time but only for patients undergoing allogeneic bone marrow transplantation (alloBMT). We conclude that in our young patient cohort, recent improvement in survival is attributed to alloBMT therapy and that ethnicity affected treatment outcome.
authors.affiliation: Hematology Department, Hebrew-University Hadassah Medical Center, Jerusalem, Israel.
authors.forename: Neta
authors.initials: N
authors.lastname: Goldschmidt
authors.forename: Sara B
authors.initials: SB
authors.lastname: Cohen
authors.forename: Moshe E
authors.initials: ME
authors.lastname: Gatt
authors.forename: Myriam
authors.initials: M
authors.lastname: Safrai
authors.forename: Deborah
authors.initials: D
authors.lastname: Rund
mesh_terms: D000328:Adult; D018912:Arabs / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews / Q000706:statistics & numerical data*; D015470:Leukemia, Myeloid, Acute / Q000208:ethnology* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
keywords: acute myeloid leukaemia; age; bone marrow transplantation; prognosis