title: The use of octreotide to manage symptoms of bronchorrhea: a case report.
abstract: Octreotide, a synthetic analogue of the hormone somatostatin, is primarily used in palliative medicine because of its antisecretory effect and has been shown to be effective in the management of bowel obstruction, nausea, and diarrhea. Octreotide also has been successfully used for the management of bronchorrhea in both inpatient and outpatient settings. We report the case of a 47-year-old female with a history of bronchioloalveolar cell carcinoma whose copious bronchial secretions were controlled with octreotide. Octreotide should be further evaluated as a first-line treatment for bronchorrhea.
authors.affiliation: Division of Hematology/Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address: mpahuja@mcvh-vcu.edu.
authors.forename: Meera
authors.initials: M
authors.lastname: Pahuja
authors.affiliation: Division of Pulmonary and Critical Care, Virginia Commonwealth University, Richmond, Virginia, USA.
authors.forename: Ray W
authors.initials: RW
authors.lastname: Shepherd
authors.affiliation: Division of Hematology/Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
authors.forename: Laurel J
authors.initials: LJ
authors.lastname: Lyckholm
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism; D001982:Bronchial Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010166:Palliative Care
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide
keywords: Bronchorrhea; bronchioloalveolar carcinoma; octreotide
references.citation: Nihon Kokyuki Gakkai Zasshi. 1998 May;36(5):482-7
references.pmid: 9742869
references.citation: Crit Rev Oncol Hematol. 2012 Sep;83(3):388-92
references.pmid: 22277783
references.citation: Clin Endocrinol (Oxf). 2006 Nov;65(5):626-30
references.pmid: 17054464
references.citation: J Med Assoc Thai. 2001 Dec;84(12):1714-20
references.pmid: 11999818
references.citation: J Pain Symptom Manage. 2006 Sep;32(3):200-2
references.pmid: 16939841
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3081-6
references.pmid: 10077640
references.citation: Lung Cancer. 2004 Aug;45(2):137-42
references.pmid: 15246183
references.citation: Chest. 1999 May;115(5):1465-8
references.pmid: 10334175
references.citation: Am Rev Respir Dis. 1975 Jun;111(6):857-62
references.pmid: 166581
references.citation: Intern Med. 2002 Mar;41(3):225-8
references.pmid: 11929186
references.citation: HIV Clin Trials. 2007 May-Jun;8(3):155-63
references.pmid: 17621462
references.citation: Oncology. 1981;38(5):269-73
references.pmid: 7022296
references.citation: Postgrad Med J. 1971 Mar;47(545):171-7
references.pmid: 5555320
references.citation: Cancer. 2000 Feb 15;88(4):770-6
references.pmid: 10679645
references.citation: Palliat Med. 1999 Sep;13(5):429-30
references.pmid: 10659116
references.citation: World J Surg Oncol. 2003 Jul 1;1(1):8
references.pmid: 12917017
references.citation: Digestion. 1990;45 Suppl 1:66-70; discussion 70-1
references.pmid: 2185968
references.citation: Chest. 2012 Feb;141(2):513-514
references.pmid: 22315118
references.citation: Lancet. 1999 Mar 6;353(9155):846
references.pmid: 10459993
references.citation: Respir Res. 2001;2(2):85-9
references.pmid: 11686870
references.citation: Respir Med. 2002 Feb;96(2):81-6
references.pmid: 11860173