title: Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium.
abstract: The aim of this study was to investigate the interaction of cadmium chloride with mineral elements in rat nephrocytes in terms of the biosynthesis of nanocomplexes. The results show that selenium supplementation enhanced cadmium accumulation in kidneys. Analysis of the fluorescence revealed an increase in red fluorescence in the kidneys of rats co-exposed to cadmium and selenium. Interestingly, X-ray diffraction measurements carried out on kidney fractions of co-exposed rats point to the biosynthesis of cadmium selenide and/or sulfide nanoparticles (about 62 nm in size). Oxidative stress assays showed the ability of selenium to reduce lipid peroxidation and to restore glutathione peroxidase and superoxide dismutase activity in kidneys. Hence, cadmium complexation with selenium and sulfur at a nanoscale level could reduce oxidative stress induced by cadmium in kidneys.
authors.affiliation: Laboratory of Integrative Physiology, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Trabelsi
authors.forename: Inès
authors.initials: I
authors.lastname: Azzouz
authors.forename: Soumaya
authors.initials: S
authors.lastname: Ferchichi
authors.forename: Olfa
authors.initials: O
authors.lastname: Tebourbi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000633:toxicity*; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013455:Sulfur / Q000494:pharmacology*
chemical_list: D002104:Cadmium; D013455:Sulfur; D012643:Selenium
keywords: X-ray diffraction; detoxification; fluorescence microscopy; kidneys; nanoparticles; oxidative stress
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