title: Nondestructive and rapid concurrent estimation of paracetamol and nimesulide in their combined dosage form using Raman spectroscopic technique.
abstract: A rapid, nondestructive Raman spectroscopic method was developed for quantitative estimation of paracetamol and nimesulide in their combined dosage form. A Raman univariate calibration model was developed by measuring the peak intensities of paracetamol and nimesulide at 853 cm(-1) and 1336 cm(-1), respectively. The developed method was successfully applied for in situ, concurrent estimation of paracetamol and nimesulide in their combined dosage and method was also validated according to International Conference on Harmonisation guidelines. Thus, the developed Raman spectroscopic method can be applied for simultaneous estimation of paracetamol and nimesulide in their combined dosage form as a process analytical technology tool by pharmaceutical industries for routine quality control.
authors.affiliation: Department of Pharmaceutical Analysis, Institute of Pharmacy, Nirma University, Sarkhej-Gandhinagar Highway, Ahmedabad-382 481, India.
authors.forename: Gargi R
authors.initials: GR
authors.lastname: Lakhwani
authors.forename: O D
authors.initials: OD
authors.lastname: Sherikar
authors.forename: Priti J
authors.initials: PJ
authors.lastname: Mehta
keywords: In situ analysis; Raman spectroscopy; nimesulide; nondestructive; paracetamol
references.citation: Analyst. 2002 Jan;127(1):144-8
references.pmid: 11827382
references.citation: J Pharm Biomed Anal. 2006 Mar 18;40(5):1225-30
references.pmid: 16253463
references.citation: Anal Chim Acta. 2007 Apr 25;589(2):192-9
references.pmid: 17418181
references.citation: J Pharm Biomed Anal. 2007 May 9;44(1):254-7
references.pmid: 17349766
references.citation: Appl Spectrosc. 2003 Apr;57(4):407-12
references.pmid: 14658637