title: Multiple-capillary measurement of RBC speed, flux, and density with optical coherence tomography.
abstract: As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynamics over many capillaries at different depths at the same time.
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
authors.forename: Jonghwan
authors.initials: J
authors.lastname: Lee
authors.forename: Weicheng
authors.initials: W
authors.lastname: Wu
authors.forename: Frederic
authors.initials: F
authors.lastname: Lesage
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002196:Capillaries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002452:Cell Count; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004912:Erythrocytes / Q000166:cytology* / Q000000981:diagnostic imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D041623:Tomography, Optical Coherence
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