title: Biomarkers of Alzheimer's disease: the present and the future.
abstract: A paradigm shift has occurred in the last ten years in the diagnostic field of Alzheimer's disease (AD). Scientific thought has enriched the concept of AD as a pathophysiological continuum and emphasized contribution of biological, morphological and functional brain imaging biomarkers for diagnosis, in particular during the early stages of the disease. We address here the present and the future of these biological biomarkers. Most of them are linked to the pathophysiological lesions of the Alzheimer process: aggregates of hyperphosphorylated tau proteins, also called neurofibrillary tangles (NFT), and extracellular deposit of amyloid-beta peptides (Aβ), also called senile plaques. The detection in the cerebrospinal fluid (CSF) of tau and Aβ represents the current diagnostic practice of AD. Improvement for a more accurate and earlier biological diagnosis is however expected using a new generation of biomarkers, mostly in relation with tau and Aβ metabolism.
authors.affiliation: Laboratoire de biochimie protéomique clinique et CCBHM, hôpital Saint-Éloi, institut de recherche en biothérapie, CHU de Montpellier, 80, avenue A.-Fliche, 34295 Montpellier cedex 5, France; Inserm U1040, université Montpellier 1, 80, avenue A.-Fliche, 34295 Montpellier cedex 5, France. Electronic address: s-lehmann@chu-montpellier.fr.
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: C
authors.initials: C
authors.lastname: Delaby
authors.forename: J
authors.initials: J
authors.lastname: Touchon
authors.forename: C
authors.initials: C
authors.lastname: Hirtz
authors.forename: A
authors.initials: A
authors.lastname: Gabelle
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003943:Diagnostic Techniques, Neurological / Q000639:trends*; D006801:Humans; D016874:Neurofibrillary Tangles / Q000378:metabolism; D016875:tau Proteins / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D016875:tau Proteins
keywords: Alzheimer; Alzheimer's disease; Biomarkers; Biomarqueurs; Diagnosis; Diagnostic; Peptides amyloïdes; Protéine Tau; Tau protein; β-amyloid peptides