title: Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort.
abstract: The aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39-41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71-13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.
authors.affiliation: Armand Trousseau Hospital, Paediatric Pulmonary Department, Research Unit INSERM U 955, National Reference Centre for Rare Lung Diseases,Pierre et Marie Curie University Paris 6,France.
authors.forename: B
authors.initials: B
authors.lastname: Fauroux
authors.affiliation: Reunion University Hospital - Hospital Group South;Centre of Perinatal Studies of Indian Ocean, Reunion Island,France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Gouyon
authors.affiliation: Department of Neonatology,Nantes University Hospital,France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Roze
authors.affiliation: Department of Paediatric Intensive Care,Besançon University Hospital,France.
authors.forename: C
authors.initials: C
authors.lastname: Guillermet-Fromentin
authors.affiliation: Department of Neonatology,Toulouse University Hospital,France.
authors.forename: I
authors.initials: I
authors.lastname: Glorieux
authors.affiliation: Department of Neonatology,Caen University Hospital,France.
authors.forename: L
authors.initials: L
authors.lastname: Adamon
authors.affiliation: Department of Paediatrics and Neonatology,Nîmes University Hospital,France.
authors.forename: M
authors.initials: M
authors.lastname: Di Maio
authors.affiliation: AbbVieFrance.
authors.forename: D
authors.initials: D
authors.lastname: Anghelescu
authors.affiliation: AbbVieFrance.
authors.forename: T
authors.initials: T
authors.lastname: Miloradovich
authors.affiliation: Department of Neonatal Intensive Care,Strasbourg University Hospital,France.
authors.forename: B
authors.initials: B
authors.lastname: Escande
authors.affiliation: Department of Paediatrics,Bordeaux University Hospital,France.
authors.forename: C
authors.initials: C
authors.lastname: Elleau
authors.affiliation: Department of Neonatology,Rouen University Hospital,France.
authors.forename: D
authors.initials: D
authors.lastname: Pinquier
mesh_terms: D001988:Bronchiolitis / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009017:Morbidity; D012135:Respiratory Sounds; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology*; D012307:Risk Factors
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