title: Effects of isoflurane anesthesia on aortic compliance and systemic hemodynamics in compliant and noncompliant aortas.
abstract: OBJECTIVE
  To investigate the effect of general anesthesia on aortic compliance and other cardiovascular hemodynamics in chronically instrumented pigs with compliant and noncompliant (stiff) aortas.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  University animal laboratory.
  
  
  METHODS
  Twelve adult Yucatan miniature pigs.
  
  
  METHODS
  Chronic instrumentation of a compliant (control; n = 7) and noncompliant (n = 5) group to measure pressure and flow in the ascending aorta. A Teflon prosthesis was wrapped around the aorta (noncompliant group) to limit wall compliance.
  
  
  RESULTS
  Hemodynamic parameters were recorded on the 15th postoperative day, both awake and after general anesthesia. Banding the aorta caused a significant decrease in arterial compliance (-49%, p<0.001) and increases in systolic blood pressure (SBP: +38%, p = 0.001) and pulse pressure (+107%, p< 0.01). Induction of anesthesia in the control group produced a 15% increase in arterial compliance (p<0.05), resulting in a subtle decrease in SBP (-12%), diastolic blood pressure (DBP; -13%) and mean blood pressure (MBP; -12%). Induction of anesthesia in the noncompliant group also caused a significant increase in arterial compliance (17%, p<0.001), but caused significant decreases in SBP (21%, p<0.01), DBP (23%, p<0.01) and MBP (22%, p<0.01) as compared with controls.
  
  
  CONCLUSIONS
  Induction of general anesthesia caused a similar increase in total arterial compliance and was associated with a decrease in SBP that was more pronounced in animals with noncompliant aortas. These results indicated that anesthesia caused a greater hemodynamic effect on noncompliant (stiff) aortas and may explain the extensive hemodynamic fluctuation and instability often observed in atherosclerotic, elderly patients with stiff aortas.
authors.affiliation: Department of Cardiothoracic & Vascular Surgery, University of Crete Medical School, Heraklion, Greece. Electronic address: ioannou@med.uoc.gr.
authors.forename: Christos V
authors.initials: CV
authors.lastname: Ioannou
authors.forename: Nikos
authors.initials: N
authors.lastname: Stergiopulos
authors.forename: Efstratios
authors.initials: E
authors.lastname: Georgakarakos
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Chatzimichali
authors.forename: Asterios N
authors.initials: AN
authors.lastname: Katsamouris
authors.forename: Denis R
authors.initials: DR
authors.lastname: Morel
mesh_terms: D000768:Anesthesia, General; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001807:Blood Vessel Prosthesis; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D003187:Compliance / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007530:Isoflurane / Q000009:adverse effects*; D011311:Pressoreceptors / Q000187:drug effects; D013552:Swine; D013556:Swine, Miniature; D059289:Vascular Stiffness
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane
keywords: arterial compliance; hemodynamics; hypertension; isoflurane; vascular prosthesis