title: Design and synthesis of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs.
abstract: A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N1,N5-bis[4-(N'-(carbamimidoyl)phenyl]glutaramide antifungal lead.
authors.affiliation: College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA. kode_rao@msn.com
authors.forename: Nageswara Rao
authors.initials: NR
authors.lastname: Kode
authors.forename: Jean J
authors.initials: JJ
authors.lastname: Vanden Eynde
authors.forename: Annie
authors.initials: A
authors.lastname: Mayence
authors.forename: Guangdi
authors.initials: G
authors.lastname: Wang
authors.forename: Tien L
authors.initials: TL
authors.lastname: Huang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000378:metabolism; D005977:Glutarates / Q000138:chemical synthesis* / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000378:metabolism; D010091:Oximes / Q000138:chemical synthesis* / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats
chemical_list: D000935:Antifungal Agents; D005977:Glutarates; D010069:Oxadiazoles; D010091:Oximes; D011355:Prodrugs
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