title: Spontaneous formation of nitrarine and polycyclic skeletons related to Nitraria indolic alkaloids under non-enzymic conditions.
abstract: Mixtures of tryptamine and reactive C5 units, presumably derived from lysine in nature, were studied to ascertain the spontaneous formation of the complex polycyclic alkaloid nitrarine. Several indolic compounds tracing the unified metabolism within the Nitraria genus were also characterized.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, LabEx LERMIT, 91191 Gif-sur-Yvette (France).
authors.forename: Edmond
authors.initials: E
authors.lastname: Gravel
authors.forename: Abha
authors.initials: A
authors.lastname: Harfouche
authors.forename: Rim
authors.initials: R
authors.lastname: Salame
authors.forename: Karine
authors.initials: K
authors.lastname: Leblanc
authors.forename: Alexandre
authors.initials: A
authors.lastname: Maciuk
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
mesh_terms: D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D054837:Quinolizidines / Q000138:chemical synthesis / Q000737:chemistry*; D029631:Sapindaceae / Q000737:chemistry* / Q000378:metabolism; D014363:Tryptamines / Q000737:chemistry
chemical_list: D026121:Indole Alkaloids; D054837:Quinolizidines; D014363:Tryptamines; C030820:tryptamine
keywords: alkaloids; biomimetic synthesis; cascade reactions; nitraria; nitrarine