title: Bis(oxalato)dioxovanadate(V) and bis(oxalato)oxoperoxo-vanadate(V) complexes: spectroscopic characterization and biological activity.
abstract: Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2] · 3H2O and K3[VO(O2)(C2O4)2] · 1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.
authors.affiliation: Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, La Plata, Argentina.
authors.forename: Ignacio E
authors.initials: IE
authors.lastname: León
authors.forename: Susana B
authors.initials: SB
authors.lastname: Etcheverry
authors.forename: Beatriz S
authors.initials: BS
authors.lastname: Parajón-Costa
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Baran
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014638:Vanadates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; C000594304:bis(oxalato)oxoperoxovanadate(V); D014638:Vanadates