title: Carcinoma ex pleomorphic adenoma. Case report.
abstract: Carcinoma ex pleomorphic adenoma (CXPA) is a rare and aggressive malignancy that usually develops in primary or recurrent pleomorphic adenoma. It occurs in 6% of all pleomorphic adenomas, of which only 7% of cases occur in minor salivary gland tumors. The rate of occurrence and malignant change increases with time if a case is left untreated. Intraorally, it is mostly seen in the palate, followed by the upper lip and buccal mucosa. CXPA of the hard palate typically presents as a painless, slow-growing swelling that frequently involves the periosteum and underlying palatal bone. Imaging of CXPA is usually noncontributory, leading to frequent misdiagnosis. Longstanding cases may extend up to the parapharyngeal space and cavernous sinus. We describe a rare case of CXPA of the palate with non-significant clinical and radiological findings. Early diagnosis for better prognosis is stressed.
authors.affiliation: Department of Oral Medicine and Radiology, M.M. College of Dental Sciences & Research, Mullane, Ambala, Haryana, India.
authors.forename: Shambulingappa
authors.initials: S
authors.lastname: Pallagatti
authors.forename: Soheyl
authors.initials: S
authors.lastname: Sheikh
authors.forename: Deepak
authors.initials: D
authors.lastname: Gupta
authors.forename: Anirban
authors.initials: A
authors.lastname: Das
authors.forename: Ravinder
authors.initials: R
authors.lastname: Singh
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D008949:Adenoma, Pleomorphic / Q000175:diagnosis*; D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010157:Palatal Neoplasms / Q000175:diagnosis*; D021362:Palate, Hard / Q000473:pathology; D010160:Palate, Soft / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*