title: Deep vein thrombosis as debut of cytomegalovirus infection associated with type II cryoglobulinemia, with antierythrocyte specificity in a kidney transplant recipient: a case report.
abstract: Immunologic alterations, such as cryoglobulinemia, have been described in the acute phase of primary cytomegalovirus (CMV) infections in immunocompetent patients. There are few references about these influences of a primary CMV infection in an at-risk kidney transplant recipient (donor positive/recipient negative-D(+)/R(-)). Herein we have described the case of a 46-year-old man, who was naive for CMV and underwent renal transplantation from a CMV+ cadaveric donor, thereby at high risk for disease transmission. The immunosuppression consisted of basiliximab, tacrolimus, mycophenolate mofetil, and steroids. The recipient was not treated with CMV prophylaxis, but rather regularly screened for possible pre-emptive treatment. At 35 days after transplantation, he was admitted because of deep vein thrombosis (DVT) in the transplant ipsilateral lower limb accompanied by oliguria, fever, and epigastric pain accompanied by type II cryoglobulinemia and acute CMV infection. The direct antiglobulin test (DAT) for C3d was positive. The cryoglobulins displayed anti-red blood cell specificity, with maximum activity at 4°C. The DVT was successfully treated with locoregional thrombolysis in combination with anticoagulant therapy. The DAT improved with CMV treatment and increased steroid therapy. The urine output and renal function tests improved with resolution of the thrombosis, achieving complete recovery without sequelae. Our hypothesis was that CMV infection triggered cryoglobulinemia. The blood disorder caused hyperviscosity, inducing DVT. This case, of CMV infection showed associated cryoglobulinemia presenting with antierythrocyte specificity in a kidney transplant recipient.
authors.affiliation: U.O.C. Chirurgia dei Trapianti, Fondazione Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Sforza
authors.forename: G
authors.initials: G
authors.lastname: Iaria
authors.forename: L
authors.initials: L
authors.lastname: Tariciotti
authors.forename: M
authors.initials: M
authors.lastname: Manuelli
authors.forename: A
authors.initials: A
authors.lastname: Anselmo
authors.forename: P
authors.initials: P
authors.lastname: Ciano
authors.forename: T M
authors.initials: TM
authors.lastname: Manzia
authors.forename: L
authors.initials: L
authors.lastname: Toti
authors.forename: G
authors.initials: G
authors.lastname: Tisone
mesh_terms: D000918:Antibody Specificity; D003449:Cryoglobulinemia / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000150:complications*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020246:Venous Thrombosis / Q000150:complications*