title: Hypercoagulability and ACTH-dependent hyperadrenocorticism in dogs.
abstract: BACKGROUND
  Dogs with hyperadrenocorticism are at risk of thromboembolic disease, which might be caused by an underlying hypercoagulable state.
  
  
  OBJECTIVE
  To assess hemostatic function in dogs with ACTH-dependent hyperadrenocorticism (ADHAC) before and after treatment.
  
  
  METHODS
  Nineteen dogs with ADHAC and 40 normal dogs.
  
  
  METHODS
  Prospective, observational study. Dogs with ADHAC were recruited from the referral hospital patient population; normal dogs were recruited from staff and students at the study's institution. Hemostasis was assessed before and at 3 and 6 months after treatment with trilostane (T0, T3, T6) by kaolin-activated thrombelastography with platelet mapping (TEG-PM), prothrombin time, activated partial thromboplastin time, fibrinogen concentration, and antithrombin activity (AT).
  
  
  RESULTS
  Dogs with ADHAC had statistically significantly increased α-angle (P < .01) and maximum amplitude (MA)(thrombin) (P < .01) on TEG-PM, and significantly decreased κ (P < .005) at T0, T3, and T6. Platelet count (P < .001) and fibrinogen concentration (P < .001), but not AT activity, were increased in dogs with ADHAC at T0, T3, and T6.
  
  
  CONCLUSIONS
  Dogs with ADHAC have thrombelastographic evidence of hypercoagulability and remained hypercoagulable during treatment. AT deficiency does not appear to be involved in the pathogenesis of hypercoagulability in this population.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON.
authors.forename: F M
authors.initials: FM
authors.lastname: Park
authors.forename: S L
authors.initials: SL
authors.lastname: Blois
authors.forename: A C G
authors.initials: AC
authors.lastname: Abrams-Ogg
authors.forename: R D
authors.initials: RD
authors.lastname: Wood
authors.forename: D G
authors.initials: DG
authors.lastname: Allen
authors.forename: S G
authors.initials: SG
authors.lastname: Nykamp
authors.forename: A
authors.initials: A
authors.lastname: Downie
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D004283:Dog Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D006929:Hyperaldosteronism / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013916:Thrombelastography / Q000662:veterinary; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000473:pathology / Q000662:veterinary*
keywords: Cushing's disease; Hemostasis; Platelet; Thrombelastography; Thromboembolism