title: Study comparing midazolam and nitrous oxide in dental anxiety control.
abstract: The purpose of this study is to comparatively assess the effect of midazolam and nitrous oxide associated with oxygen, in lower third molar extractions, on the change in the anxiety level of patients by salivary cortisol dosage. Twenty-eight male patients underwent lower third molar extraction under sedation with midazolam and nitrous oxide. Objective (salivary cortisol dosage) and subjective (Corah Dental Anxiety Scale) data have been obtained. By salivary cortisol, 40 minutes after midazolam administration, there has been a statistically significant difference compared with the mean baseline value. Midazolam was the most effective sedation method for reducing salivary cortisol level.
authors.affiliation: From the Oral and Maxillofacial Surgery and Periodontology Department, Ribeirão Preto Dental School, São Paulo University, São Paulo, Brazil.
authors.forename: Darklilson
authors.initials: D
authors.lastname: Pereira-Santos
authors.forename: Marcus Antônio
authors.initials: MA
authors.lastname: Brêda-Júnior
authors.forename: Emanuela Prado
authors.initials: EP
authors.lastname: Ferraz
authors.forename: Grasiele Edilaine
authors.initials: GE
authors.lastname: Crippa
authors.forename: Fabíola Singaretti
authors.initials: FS
authors.lastname: de Oliveira
authors.forename: Valdemar Mallet
authors.initials: VM
authors.lastname: da Rocha-Barros
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D016292:Procedural Sedation / Q000379:methods*; D016854:Dental Anxiety / Q000517:prevention & control* / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008334:Mandible / Q000601:surgery; D008874:Midazolam / Q000008:administration & dosage*; D008964:Molar, Third / Q000601:surgery; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage; D012463:Saliva / Q000737:chemistry; D014081:Tooth Extraction / Q000379:methods; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D006993:Hypnotics and Sedatives; D009609:Nitrous Oxide; D008874:Midazolam; D010100:Oxygen; D006854:Hydrocortisone