title: Innate immune cells in asthma.
abstract: Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.
authors.affiliation: Laboratory of Immunoregulation and Mucosal Immunology, DMBR-VIB, Zwijnaarde, Belgium; Laboratory of Immunoregulation, Ghent University, Ghent, Belgium; Cytokine Receptor Laboratory, VIB Department of Medical Protein Research, Ghent, Belgium.
authors.forename: Julie
authors.initials: J
authors.lastname: Deckers
authors.forename: Filipe
authors.initials: F
authors.lastname: Branco Madeira
authors.forename: Hamida
authors.initials: H
authors.lastname: Hammad
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D001491:Basophils / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
keywords: Th2; asthma; innate cells; lung