title: Novel biosensing methodologies for ultrasensitive detection of viruses.
abstract: Various infectious diseases caused by the spread of viruses create adverse implications on global biosecurity. Increasing demands for virus surveillance and effective control of the spread of diseases reveal the need for rapid and sensitive virus diagnostic devices. Due to the remarkable sensitivity and specificity of biosensors, they appear as a potential and promising tool for accurate and quantitative detection of viruses. Furthermore, recent advancements in transduction systems, nanotechnology and genetic engineering offer various strategies to improve the detection performance of biosensors. This review presents an overview of the current states of novel biosensing methodologies for the ultrasensitive detection of viruses with highly promising applications for future disease diagnosis. Additionally, a brief summary of the recent state-of-the-art virus diagnostic molecular technologies is included.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371. cstoh@ntu.edu.sg.
authors.forename: Ming Soon
authors.initials: MS
authors.lastname: Cheng
authors.forename: Chee-Seng
authors.initials: CS
authors.lastname: Toh
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods / Q000639:trends*; D004867:Equipment Design / Q000379:methods / Q000639:trends; D006801:Humans; D036103:Nanotechnology / Q000379:methods / Q000639:trends*; D014780:Viruses / Q000302:isolation & purification*