title: Prostate volume correlates with diabetes in elderly benign prostatic hyperplasia patients.
abstract: BACKGROUND
  To evaluate the relationship between prostate volume (PV) and diabetes mellitus (DM) in geriatric benign prostatic hyperplasia (BPH) patients.
  
  
  METHODS
  One hundred and seventeen geriatric patients with BPH were retrospectively studied between 2008 and 2009. Patients were divided into two groups: BPH and BPH with DM group. The effects of indexes of DM, including fasting blood glucose (FBG), 2-h postprandial blood glucose, glycosylated hemoglobin (HbA1c), fasting insulin (FINS), insulin resistance (IR) index, prostate-specific antigen (PSA), International Prostate Symptom Score (IPSS), and lower urinary tract symptoms (LUTS) were evaluated.
  
  
  RESULTS
  The values of PV (P = 0.005), PSA (P = 0.013), and IPSS (P = 0.01) in the BPH patients with DM group were significantly higher than in the BPH group. The values of PV (P = 0.002) and PSA (P = 0.006) in the BPH patients with elevated FBG were significantly higher than in the BPH patients with normal FBG. BPH patients with elevated HbA1c had significantly higher PV than BPH patients with normal HbA1c (P = 0.046). BPH with hyperinsulinemia group showed significantly higher PV (P = 0.017) and longer duration of LUTS (P = 0.031) than BPH patients with normal FINS. Similarly, BPH patients with IR had higher PV (P = 0.004) and longer duration of LUTS (P = 0.036) than BPH patients without IR. The logistic regression analysis showed that FBG and FINS were the risk factors for BPH.
  
  
  CONCLUSIONS
  Our study demonstrates that PV is closely correlated with diabetes and diabetes has a direct effect on the occurrence and development of BPH.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Qu
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Huang
authors.forename: Xianqin
authors.initials: X
authors.lastname: Meng
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Lini
authors.initials: L
authors.lastname: Dong
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000473:pathology*; D012189:Retrospective Studies
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