title: Early diastolic dysfunction is associated with intensive care unit mortality in cancer patients presenting with septic shock.
abstract: BACKGROUND
  Cancer patients present a high risk of sepsis and are exposed to cardiotoxic drugs during chemotherapy. Myocardial dysfunction is common during septic shock and can be evaluated at bedside using echocardiography. The aim of this study was to identify early cardiac dysfunctions associated with intensive care unit (ICU) mortality in cancer patients presenting with septic shock.
  
  
  METHODS
  Seventy-two cancer patients admitted to the ICU underwent echocardiography within 48 h of developing septic shock. History of malignancies, anticancer treatments, and clinical characteristics were prospectively collected.
  
  
  RESULTS
  ICU mortality was 48%. Diastolic dysfunction (e' ≤8 cm s(-1)) was an independent echocardiographic parameter associated with ICU mortality {odds ratio (OR) 7.7 [95% confidence interval (CI), 2.58-23.38]; P<0.001}. Overall, three factors were independently associated with ICU mortality: sepsis-related organ failure assessment score at admission [OR 1.35 ( 95% CI, 1.05-1.74); P=0.017], occurrence of diastolic dysfunction [OR 16.6 (95% CI, 3.28-84.6); P=0.001], and need for conventional mechanical ventilation [OR 16.6 (95% CI, 3.6-77.15); P<0.001]. Diastolic dysfunction was not associated with exposure to cardiotoxic drugs.
  
  
  CONCLUSIONS
  Early diastolic dysfunction is a strong and independent predictor of mortality in cancer patients presenting with septic shock. It is not associated with exposure to cardiotoxic drugs. Further studies incorporating monitoring of diastolic function and therapeutic interventions improving cardiac relaxation need to be evaluated in cancer patients presenting with septic shock.
authors.affiliation: Department of Anaesthesia and Intensive Care Unit, Paoli-Calmettes Institute, 232 bd Sainte Marguerite, 13273 Marseille Cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Mourad
authors.forename: L
authors.initials: L
authors.lastname: Chow-Chine
authors.forename: M
authors.initials: M
authors.lastname: Faucher
authors.forename: A
authors.initials: A
authors.lastname: Sannini
authors.forename: J P
authors.initials: JP
authors.lastname: Brun
authors.forename: J M
authors.initials: JM
authors.lastname: de Guibert
authors.forename: L
authors.initials: L
authors.lastname: Fouche
authors.forename: J
authors.initials: J
authors.lastname: Lambert
authors.forename: J L
authors.initials: JL
authors.lastname: Blache
authors.forename: D
authors.initials: D
authors.lastname: Mokart
mesh_terms: D000368:Aged; D003971:Diastole; D004452:Echocardiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality* / Q000503:physiopathology; D012772:Shock, Septic / Q000401:mortality* / Q000503:physiopathology
keywords: cancer; diastolic dysfunction; echocardiography; prognosis; sepsis; septic shock