title: Identification of MHC class I sequences in four species of Macaca of China.
abstract: Tibetan macaques (Macaca thibetana), stump-tailed macaques (M. arctoides), Assamese macaques (M. assamensis), and northern pig-tailed macaques (M. leonina) are four major species of Macaca in China. In order to effectively use these species in biomedical research, thorough investigations of their MHC immunogenetics are required. In this study, we identified MHC class I sequences using cDNA cloning and sequencing on a cohort of six M. thibetana, three M. arctoides, three M. assamensis, and three M. leonina derived from Sichuan and Yunnan provinces of China. Eighty new alleles were identified, including 26 MHC-A alleles, 46 MHC-B alleles, and 8 MHC-I alleles. Among them, Math-A1*126:01, Math-B*190:01, Math-B*191:01, Math-B*192:01, Maar-A1*127:01, Maar-A1*129:01, and Maas-A1*128:01 represent lineages that had not been reported earlier in Macaca. Phylogenetic analyses show that no obvious separation of lineages among these species of Macaca. This study provides important information about the MHC immunogenetics for the four major species of Chinese macaques and adds value to these species as model organisms in biomedical research.
authors.affiliation: Laboratory Animal Center, Academy of Military Medical Science, Beijing, 100071, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.forename: Aixue
authors.initials: A
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Zeng
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Cao
authors.forename: Jianbin
authors.initials: J
authors.lastname: He
authors.forename: Longbao
authors.initials: L
authors.lastname: Lv
authors.forename: Lihua
authors.initials: L
authors.lastname: Sui
authors.forename: Huahu
authors.initials: H
authors.lastname: Ye
authors.forename: Junwen
authors.initials: J
authors.lastname: Fan
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Cui
authors.forename: Zhaozeng
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000483:Alleles; D000818:Animals; D002681:China; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D005838:Genotype; D008251:Macaca / Q000235:genetics* / Q000276:immunology; D010802:Phylogeny; D013045:Species Specificity
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