title: The Anti-Inflammatory Effects of a New Herbal Formula (WSY-1075) in a Nonbacterial Prostatitis Rat Model.
abstract: OBJECTIVE
  The aim of this study was to investigate the anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model.
  
  
  METHODS
  Prostatitis was induced in male Wistar rats (n=32) by treatment with 17 beta-estradiol and dihydrotestosterone for 4 weeks. After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8). After 4 weeks of treatment, the prostatic proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-8) levels and histological findings were noted.
  
  
  RESULTS
  The ciprofloxacin and WSY-1075 treatment groups showed significantly decreased proinflammatory cytokine levels compared with the control group. Histologically, treatment with ciprofloxacin and WSY-1075 significantly suppressed the severity of prostatitis lesions compared with those in the control group. No differences in the proinflammatory cytokine levels or histologic findings were observed with the dose dependent treatment of WSY-1075.
  
  
  CONCLUSIONS
  The new herbal formula, WSY-1075, showed effective anti-inflammatory activities in the prostate and may be useful for the clinical treatment of nonbacterial prostatitis. Our findings suggest that WSY-1075 has a beneficial effect on the prevention and treatment of nonbacterial prostatitis.
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Yoon
authors.forename: Woong Jin
authors.initials: WJ
authors.lastname: Bae
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Hyo Sin
authors.initials: HS
authors.lastname: Kim
authors.forename: U Syn
authors.initials: US
authors.lastname: Ha
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Sohn
authors.forename: Sung-Yeoun
authors.initials: SY
authors.lastname: Hwang
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Kim
keywords: Herbals; Inflammation; Prostatitis
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