title: Production of Angkak Through Co-Culture of Monascus Purpureus and MONASCUS RUBER.
abstract: Angkak (red mold rice, red yeast rice, Chinese red rice) is a traditional Chinese medicine produced by solid-state fermentation of cooked non-glutinous rice with Monascus species. The secondary metabolite of Monascus species, monacolin K /lovastatin, has been proven to lower blood lipid levels. In this study, a co-culture of Monascus purpureus MTCC 369 and Monascus ruber MTCC 1880 was used for angkak production. Four medium parameters screened by Plackett-Burman design were optimized by response surface methodology for highest lovastatin production in angkak during solid-state fermentation by the co-culture. Maximum lovastatin production of 2.84 mg g(-1) was predicted in solid medium containing 20 g rice and 40 ml liquid nutrients medium (malt extract 9.68 g l(-1), dextrose 38.90 g l(-1), MnSO4.H2O 1.96 g l(-1), and MgSO4.7H2O 0.730 g l(-1)) by point prediction tool of Design Expert 7.1 software (Statease Inc. USA).
authors.affiliation: Pharmaceutical Biotechnology Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) , Hamdard Nagar, New Delhi , India-110062.
authors.forename: Bibhu Prasad
authors.initials: BP
authors.lastname: Panda
authors.forename: Saleem
authors.initials: S
authors.lastname: Javed
authors.forename: Mohd
authors.initials: M
authors.lastname: Ali
keywords: Angkak; Co-culture; Lovastatin; Monascus purpureus; Monascus ruber; Response surface methodology
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