title: Ambient air pollution and hypertensive disorder of pregnancy.
abstract: BACKGROUND
  Ambient air pollution has been implicated in the development of hypertensive disorders of pregnancy (HDP). However, evidence of the association between air pollution and HDP is still limited, and the effects of gaseous air pollutants on HDP and their time windows of exposure have not been well studied.
  
  
  METHODS
  We used the Florida birth registry data to investigate the associations between air pollutants (NO2, SO2, PM(2.5), O3 and CO) and the risks of HDP in 22,041 pregnant women in Jacksonville, Florida, USA from 2004 to 2005. Further, we examined whether air pollution exposure during different time windows defined by trimesters and the entire pregnancy had different effects on HDP.
  
  
  RESULTS
  The single-pollutant logistic regression model showed that exposure to four pollutants during the full pregnancy period was significantly associated with prevalence of HDP after adjusting for covariates: NO2 (OR=1.21, 95% CI 1.09 to 1.35), PM2.5 (OR=1.24, 95% CI 1.08 to 1.43), SO2 (OR=1.13, 95% CI 1.01 to 1.25) and CO (OR=1.12, 95% CI 1.03 to 1.22) per IQR increase. Similar effects were observed when first trimester exposure to NO2, SO2 and CO, and second trimester exposures to PM2.5 were examined. Consistent results were confirmed in multiple-pollutant models.
  
  
  CONCLUSIONS
  This study suggests that exposure to high levels of air pollution during early pregnancy and the full gestational period was associated with increased prevalence of HDP in Florida, USA.
authors.affiliation: Department of Epidemiology, College of Public Health and Health Professional and College of Medicine, University of Florida, , Gainesville, Florida, USA.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Hu
authors.forename: Sandie
authors.initials: S
authors.lastname: Ha
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Roth
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D001719:Birth Certificates; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D005260:Female; D005431:Florida / Q000453:epidemiology; D062305:Geographic Mapping; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology / Q000209:etiology*; D016015:Logistic Models; D052638:Particulate Matter / Q000009:adverse effects* / Q000032:analysis; D011247:Pregnancy; D011264:Pregnancy Trimesters; D055815:Young Adult
chemical_list: D052638:Particulate Matter
keywords: Air Pollution; Hypertension; Pregnancy
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