title: Osteoporosis detection by 3T diffusion tensor imaging and MRI spectroscopy in women older than 60 years.
abstract: Aim of this study was to evaluate the cancellous bone quality of postmenopausal women (age >60 years) by diffusion tensor imaging (DTI) using mean diffusivity (MD) and fractional anisotropy (FA) in combination with proton magnetic resonance spectroscopy (1H-MRS). 20 postmenopausal women older than 60 years were introduced to dual-energy X-ray absorptiometry (DXA) examination in femoral neck and to an MRI spectroscopy and DTI evaluation at 3T. We observed that fat fraction (FF) can discriminate healthy and osteoporotic patients. Water mean diffusivity (MD) and FA can discriminate the healthy group from osteopenic and osteoporotic group. MD/FF vs FA/FF graph extracted from the femoral neck identifies all healthy individuals, according to DXA results. DTI and spectroscopy protocol performed in the femoral neck could be highly sensitive and specific in identifying healthy subjects.
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Rome University Tor Vergata, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Manenti
authors.forename: S
authors.initials: S
authors.lastname: Capuani
authors.forename: Armando
authors.initials: A
authors.lastname: Fusco
authors.forename: E
authors.initials: E
authors.lastname: Fanucci
authors.forename: U
authors.initials: U
authors.lastname: Tarantino
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016880:Anisotropy; D015992:Body Mass Index; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005272:Femur Neck / Q000473:pathology; D064368:Healthy Volunteers; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis* / Q000473:pathology*; D017698:Postmenopause; D011522:Protons; D012680:Sensitivity and Specificity; D014867:Water / Q000737:chemistry
chemical_list: D011522:Protons; D014867:Water