title: Cardioprotective effects of adenosine within the border and remote areas of myocardial infarction.
abstract: BACKGROUND
  Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects of adenosine after MI using electrocardiogram-triggered 18 F-fluorodeoxyglucose positron emission tomography.
  
  
  METHODS
  Wistar rats were subjected to coronary ligation and randomized into three groups treated daily for 2 months by NaCl (control; n = 7), 2-chloroadenosine (CADO; n = 8) or CADO with 8-sulfophenyltheophilline, an antagonist of adenosine receptors (8-SPT; n = 8).
  
  
  RESULTS
  After 2 months, control rats exhibited left ventricular remodelling, with increased end-diastolic volume and decreased ejection fraction. Left ventricular remodelling was not significantly inhibited by CADO. Segmental contractility, as assessed by the change in myocardial thickening after 2 months, was improved in CADO rats compared to control rats (+1.6% ± 0.8% vs. -2.3% ± 0.8%, p < 0.001). This improvement was significant in border (+5.6% ± 0.8% vs. +1.5% ± 0.8%, p < 0.001) and remote (-4.0% ± 1.0% vs. -10.4% ± 1.3%, p < 0.001) segments, but absent in MI segments. Histological analyses revealed that CADO reduced fibrosis, cardiomyocyte hypertrophy and apoptosis. Protective effects of CADO were blunted by 8-SPT.
  
  
  CONCLUSIONS
  Long-term administration of adenosine protects the left ventricle from contractile dysfunction following MI.
authors.affiliation: Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, 84 Val Fleuri, Luxembourg L1526, Luxembourg. yvan.devaux@crp-sante.lu.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Bousquenaud
authors.forename: Fatiha
authors.initials: F
authors.lastname: Maskali
authors.forename: Sylvain
authors.initials: S
authors.lastname: Poussier
authors.forename: Jennifer
authors.initials: J
authors.lastname: Zangrando
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Marie
authors.forename: Henri
authors.initials: H
authors.lastname: Boutley
authors.forename: Renaud
authors.initials: R
authors.lastname: Fay
authors.forename: Gilles
authors.initials: G
authors.lastname: Karcher
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wagner
authors.forename: Yvan
authors.initials: Y
authors.lastname: Devaux
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