title: Combined liver and kidney transplantation in primary hyperoxaluria: a report of three cases and review of the literature.
abstract: Primary hyperoxaluria type-1 (PH-1) is a rare autosomal recessive metabolic disorder leading to excessive oxalate production, deposition of calcium oxalate crystals in the kidney, nephrocalcinosis, progressive renal failure and systemic deposition of oxalate (oxalosis). Combined liver and kidney transplantation (LKT), which has been accepted as the treatment of choice for PH-1, has considerably improved patient and graft survival. Herein, we report our experience of three children with PH-1 who underwent combined LKT, with a review of the literature.
authors.affiliation: Department of Nephrology, Hamad Al Essa, Organ Transplant Center, Kuwait. drprasadnair@hotmail.com
authors.forename: Prasad
authors.initials: P
authors.lastname: Nair
authors.forename: Torki
authors.initials: T
authors.lastname: Al-Otaibi
authors.forename: Narayanan
authors.initials: N
authors.lastname: Nampoory
authors.forename: Wafa'a
authors.initials: W
authors.lastname: Al-Qabandi
authors.forename: Tarek
authors.initials: T
authors.lastname: Said
authors.forename: Medhat Abdul
authors.initials: MA
authors.lastname: Halim
authors.forename: Osama
authors.initials: O
authors.lastname: Gheith
mesh_terms: D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D006085:Graft Survival; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male