title: The impact of neurochemical mediators on antidepressant effectiveness.
abstract: Despite marked differences in the psychobiological profiles of depressed patients, clinical research has not supported selection of antidepressant (AD) medications based on neurochemistry. Prescribers have been advised to start all patients on the same class of ADs and then switch or combine them until benefit is achieved. New research may transform this practice. By matching clinical moderators to neurochemical mediators, health professionals may finally be able to overcome the disappointing remission rates associated with initial AD treatments and avoid the progressively worsening results associated with current trial and error approaches.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles , Los Angeles, California 90095, United States.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Metzner
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002395:Catecholamines / Q000494:pharmacology; D019317:Evidence-Based Medicine; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015394:Molecular Structure; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012074:Remission Induction; D012701:Serotonin / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D002395:Catecholamines; D018377:Neurotransmitter Agents; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
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