title: Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.
abstract: Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature.
authors.affiliation: Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Federau
authors.forename: Patric
authors.initials: P
authors.lastname: Hagmann
authors.forename: Philippe
authors.initials: P
authors.lastname: Maeder
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Reto
authors.initials: R
authors.lastname: Meuli
authors.forename: Matthias
authors.initials: M
authors.lastname: Stuber
authors.forename: Kieran
authors.initials: K
authors.lastname: O'Brien
mesh_terms: D000465:Algorithms; D020771:Anterior Cerebral Artery / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D003971:Diastole / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D009038:Motion; D010477:Perfusion; D012039:Regional Blood Flow / Q000502:physiology; D013599:Systole / Q000502:physiology; D013997:Time Factors; D055815:Young Adult
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