title: Arylation of diazoesters by a transient N-H insertion organocascade.
abstract: It takes two: A unique organocatalyzed cascade for the unsymmetric double arylation of α-nitrodiazoesters is described. This organocascade features the strategic use of carbene-activating anilines in conjunction with a urea catalyst, thus allowing for the synthesis of pharmaceutically attractive α-diarylesters through a transient NH insertion process.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210 (USA) http://mattson.group.chemistry.ohio-state.edu/
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Auvil
authors.forename: Sonia S
authors.initials: SS
authors.lastname: So
authors.forename: Anita E
authors.initials: AE
authors.lastname: Mattson
keywords: carbenes; diazo compounds; insertion; organocatalysis; synthetic methods