title: Management of peripheral pulmonary emboli with the use of transvenous catheter-directed thrombolysis and right ventricular assist device.
abstract: OBJECTIVE
  Pulmonary emboli (PE) can result in significant hemodynamic instability that requires urgent intervention; however, the management of peripheral emboli has been controversial.
  
  
  METHODS
  We present two patients in whom a right ventricular assist device (RVAD) was used in treating peripheral pulmonary embolism, applying the technique of pulmonary artery catheter-directed thrombolysis after resuscitation with an RVAD.
  
  
  RESULTS
  The clot burden was not suitable for surgical embolectomy due to its peripheral locations. The patients' hemodynamic conditions improved with thrombolytic therapy and gradually were weaned off the RVAD. Follow-up scans showed near resolution of all PE.
  
  
  CONCLUSIONS
  Catheter-directed thrombolysis with an RVAD as an adjunct should be considered in management of peripheral PE.
authors.affiliation: Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: Sameh M
authors.initials: SM
authors.lastname: Said
authors.forename: Khaled F
authors.initials: KF
authors.lastname: Salhab
authors.forename: Lyle D
authors.initials: LD
authors.lastname: Joyce
mesh_terms: D000368:Aged; D002407:Catheterization, Swan-Ganz / Q000379:methods*; D003952:Diagnostic Imaging; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D012151:Resuscitation / Q000379:methods; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator