title: Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle.
abstract: Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.
authors.affiliation: Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, Barshop Institute of Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Zamilpa
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying Ann
authors.initials: YA
authors.lastname: Chiao
authors.forename: Lisandra E
authors.initials: LE
authors.lastname: de Castro Brás
authors.forename: Ganesh V
authors.initials: GV
authors.lastname: Halade
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Sander O
authors.initials: SO
authors.lastname: Hacker
authors.forename: Merry L
authors.initials: ML
authors.lastname: Lindsey
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000601:surgery; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism*; D006352:Heart Ventricles / Q000378:metabolism* / Q000473:pathology*; D007442:Intubation, Intratracheal; D008026:Ligation; D051379:Mice; D009203:Myocardial Infarction / Q000209:etiology* / Q000473:pathology*; D014656:Vascular Surgical Procedures; D020257:Ventricular Remodeling; D014945:Wound Healing
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