title: Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: an approach to α-ketoesters.
abstract: The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of α-ketoesters has been developed. This method combines C-C σ-bond cleavage, dioxygen activation and oxidative C-H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to α-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Xue Yuan Road 38, Beijing 100191, P.R. China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Feng
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004951:Esterification; D007659:Ketones / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*
chemical_list: D007659:Ketones; D002244:Carbon; D003300:Copper; D010100:Oxygen