title: [The results of proton radiosurgery for pituitary endosellar adenomas].
abstract: 465 patients with pituitary endosellar adenomas have passed irradiation on the synchrocyclotron PNPI (1000 MeV). Due to the high energy of the proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given. In patients with prolactin adenomas clinical remission was detected in 80%, and the stabilization of the disease was achieved in 15%. Pregnancies in 21 patients ended in the birth of healthy children, and 4 of them gave the birth twice. Complete clinical remission was observed in 92% of patients with Cushing's disease. Sustained recovery and full normalization of growth hormone level were observed during long-term follow-up in 86% of patients with acromegaly. There was significant reducing of the high hormone level on the fifth year of follow-up in any clinical form of pituitary adenomas while the development of the secondary hypopituitarism was not defected in the most of the patients. Clinical remission in patients with non-secreting adenomas was 95%. Irradiation by the proton beam was not accompanied by serious life-threatening complications. Thus this type of treatment for pituitary endosellar adenomas is highly effective and safe and, sometimes, the only method.
authors.forename: A M
authors.initials: AM
authors.lastname: Granov
authors.forename: R A
authors.initials: RA
authors.lastname: Shalek
authors.forename: D L
authors.initials: DL
authors.lastname: Karlin
authors.forename: V M
authors.initials: VM
authors.lastname: Vinogradov
authors.forename: N N
authors.initials: NN
authors.lastname: Ialynych
authors.forename: T V
authors.initials: TV
authors.lastname: Pushkareva
authors.forename: O P
authors.initials: OP
authors.lastname: Zargarova
authors.forename: S V
authors.initials: SV
authors.lastname: Gerasimov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Koshkin
mesh_terms: D000236:Adenoma / Q000097:blood / Q000601:surgery*; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010907:Pituitary Hormones / Q000097:blood* / Q000528:radiation effects; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011388:Prolactin / Q000097:blood; D061766:Proton Therapy; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010907:Pituitary Hormones; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone