title: Metalation dictates remote regioselectivity: ruthenium-catalyzed functionalization of meta C(Ar)-H Bonds.
abstract: Remote control: The title reaction is effective for the sulfonation and alkylation of arenes bearing directing groups. Initial ortho metalation of the substrate forms an intermediate which does not evolve towards functionalization at the CM bond. Instead, the ruthenium catalyst acts as a strong electron-donating group, thus directing a remote electrophilic attack.
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London (UK) http://webspace.qmul.ac.uk/ilarrosa/index.html.
authors.forename: Francisco
authors.initials: F
authors.lastname: Juliá-Hernández
authors.forename: Marco
authors.initials: M
authors.lastname: Simonetti
authors.forename: Igor
authors.initials: I
authors.lastname: Larrosa
mesh_terms: D000478:Alkylation; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D012428:Ruthenium
keywords: CH activation; alkylation; arenes; regioselectivity; ruthenium