title: Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.
abstract: The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
authors.affiliation: Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, Pennsylvania 16802.
authors.forename: Tian
authors.initials: T
authors.lastname: Yu
authors.forename: John
authors.initials: J
authors.lastname: Bachman
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Lai
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D034622:RNA Interference; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D025521:Tumor Suppressor Proteins; C092745:LATS1 protein, human; C406449:LATS2 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Hippo signaling; LATS1; LATS2; human cancer; protein kinase
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