title: Serum ischaemia-modified albumin level is an irrelevant predictive factor for ischaemic duration in mesenteric ischaemia.
abstract: BACKGROUND
  Acute mesenteric ischaemia is an emergency condition that requires urgent and expeditious diagnosis and immediate surgical or medical intervention. The initial hours are critical for the recovery of the affected bowel segment. Thus, its clinic diagnostic biomarkers are important when it comes to reducing mortality and morbidity rates.
  
  
  METHODS
  Twenty-four male Sprague-Dawley rats were included in the study. The rats were divided into three equal groups. Those in Group I were sacrificed to determine the basal serum values of ischaemia-modified albumin (IMA) after a simple laparotomy. The superior mesenteric artery (SMA) was clamped in a simple laparotomy in Groups II and III; blood samples were taken at 120 minutes in Group II and 360 minutes in Group III. The serum IMA levels were identified from the blood samples and the results obtained were compared statistically.
  
  
  RESULTS
  The serum IMA levels were determined to be 22±6 (22) μ/L, 34±7 (34) μ/L and 36±4 (37) μ/L in Groups I, II and III, respectively. The differences between the groups were not statistically significant.
  
  
  CONCLUSIONS
  Our results showed that the serum IMA level is not an appropriate biomarker for acute mesenteric ischaemia. Additionally, the IMA level is not an appropriate biomarker for the detection of ischaemia duration. However, future studies should be conducted to clarify the efficacy of serum IMA levels under different ischaemic conditions.
authors.affiliation: Department of Cardiovascular Surgery, Medical School of Dicle University, Diyarbakir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Caliskan
authors.forename: C
authors.initials: C
authors.lastname: Yavuz
authors.forename: O
authors.initials: O
authors.lastname: Karahan
authors.forename: Sinan
authors.initials: S
authors.lastname: Demirtas
authors.forename: S
authors.initials: S
authors.lastname: Yazici
authors.forename: O
authors.initials: O
authors.lastname: Guclu
authors.forename: B
authors.initials: B
authors.lastname: Mavitas
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D008297:Male; D065666:Mesenteric Ischemia / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin
keywords: acute mesenteric ischaemia; biomarker; diagnosis; ischaemia modified albumin; muscle structures