title: Pharmacologically triggered hydrogel for scheduling hepatitis B vaccine administration.
abstract: The simplification of current vaccine administration regimes is of crucial interest in order to further sustain and expand the high impact of vaccines for public health. Most vaccines including the vaccine against hepatitis B need several doses to achieve protective immunization. In order to reduce the amount of repetitive injections, depot-based approaches represent a promising strategy. We present the application of novobiocin-sensitive biohybrid hydrogels as a depot for the pharmacologically controlled release of a vaccine against hepatitis B. Upon subcutaneous implantation of the vaccine depot into mice, we were able to release the vaccine by the oral administration of the stimulus molecule novobiocin resulting in successful immunization of the mice. This material-based vaccination regime holds high promises to replace classical vaccine injections conducted by medical personnel by the simple oral uptake of the stimulus thereby solving a major obstacle in increasing hepatitis B vaccination coverage.
authors.affiliation: 1] Faculty of Biology, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg, Germany [2] Spemann Graduate School of Biology and Medicine SGBM, University of Freiburg, Albertstrasse 19A, 79104 Freiburg, Germany.
authors.forename: Raphael J
authors.initials: RJ
authors.lastname: Gübeli
authors.forename: Katrin
authors.initials: K
authors.lastname: Schöneweis
authors.forename: Daniela
authors.initials: D
authors.lastname: Huzly
authors.forename: Martin
authors.initials: M
authors.lastname: Ehrbar
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Charpin-El Hamri
authors.forename: Marie Daoud
authors.initials: MD
authors.lastname: El-Baba
authors.forename: Stephan
authors.initials: S
authors.lastname: Urban
authors.forename: Wilfried
authors.initials: W
authors.lastname: Weber
mesh_terms: D049933:Aminocoumarins / Q000737:chemistry; D000818:Animals; D027081:DNA Gyrase / Q000737:chemistry; D003692:Delayed-Action Preparations; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D020100:Hydrogels / Q000737:chemistry; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D014611:Vaccination
chemical_list: D049933:Aminocoumarins; D003692:Delayed-Action Preparations; D017325:Hepatitis B Vaccines; D020100:Hydrogels; D011092:Polyethylene Glycols; D027081:DNA Gyrase; C004628:coumermycin
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