title: Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine.
abstract: Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.
authors.affiliation: Department of Neurology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 1665 Kongjiang Road, Shanghai, People’s Republic of China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Hong
authors.forename: Liangming
authors.initials: L
authors.lastname: Wei
authors.forename: Fei
authors.initials: F
authors.lastname: Wu
authors.forename: Zaozhan
authors.initials: Z
authors.lastname: Wu
authors.forename: Lizhu
authors.initials: L
authors.lastname: Chen
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Weien
authors.initials: W
authors.lastname: Yuan
mesh_terms: D020341:Absorbable Implants; D000279:Administration, Cutaneous; D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004867:Equipment Design; D006801:Humans; D009339:Needles; D012995:Solubility; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D014612:Vaccines
keywords: biodegradable; dissolving; microneedle; sustained release
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