title: Prospective neurochemical characterization of child offspring of parents with bipolar disorder.
abstract: We wished to determine whether decreases in N-acetyl aspartate (NAA) and increases in myoinositol (mI) concentrations as a ratio of creatine (Cr) occurred in the dorsolateral prefrontal cortex (DLPFC) of pediatric offspring of parents with bipolar disorder (BD) and a healthy comparison group (HC) over a 5-year period using proton magnetic resonance spectroscopy ((1)H-MRS). Paticipants comprised 64 offspring (9-18 years old) of parents with BD (36 with established BD, and 28 offspring with symptoms subsyndromal to mania) and 28 HCs, who were examined for group differences in NAA/Cr and mI/Cr in the DLPFC at baseline and follow-up at either 8, 10, 12, 52, 104, 156, 208, or 260 weeks. No significant group differences were found in metabolite concentrations at baseline or over time. At baseline, BD offspring had trends for higher mI/Cr concentrations in the right DLPFC than the HC group. mI/Cr concentrations increased with age, but no statistically significant group differences were found between groups on follow-up. It may be the case that with intervention youth at risk for BD are normalizing otherwise potentially aberrant neurochemical trajectories in the DLPFC. A longer period of follow-up may be required before observing any group differences.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA. Electronic address: mksingh@stanford.edu.
authors.forename: Manpreet K
authors.initials: MK
authors.lastname: Singh
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Adleman
authors.forename: Meghan
authors.initials: M
authors.lastname: Howe
authors.forename: Layla
authors.initials: L
authors.lastname: Bararpour
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Kelley
authors.forename: Daniel
authors.initials: D
authors.lastname: Spielman
authors.forename: Kiki D
authors.initials: KD
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001714:Bipolar Disorder / Q000473:pathology*; D002648:Child; D016241:Child of Impaired Parents; D003401:Creatine / Q000378:metabolism; D005192:Family Health; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017397:Prefrontal Cortex / Q000378:metabolism*; D011522:Protons
chemical_list: D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine
keywords: Bipolar; Longitudinal; Myoinositol; N-acetyl aspartate (NAA); Offspring
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