title: [Study on leuprorelin acetate in treatment of uterine adenomyosis with infertility].
abstract: OBJECTIVE
  To study clinical efficacy of leuprorelin acetate in treatment of uterine adenomyosis with infertility.
  
  
  METHODS
  From January 1,2011 to March 31,2012, 166 cycles in 166 infertile patients combined with uterine adenomyosis undergoing in vitro fertilization embryo transplant (IVF-ET) with long protocol ovum induction by leuprorelin acetate in centre of medical reproduction, ningbo women and children's hospital were studied retrospectively. In the mean time, 200 cycles in 200 infertile patients with tubal factors were enrolled as control group.The volume of uterus and outcome of IVF-ET were compared and studied between two groups.
  
  
  RESULTS
  (1) Volume of uterus:in adenomyosis group, after 2-6 cycles of injecting leuprorelin acetate (3.75 mg/28 days), the mean uterine volume was shrinked from (180 ± 73) cm(3) to (86 ± 67) cm(3) (P < 0.05). (2) Outcome of IVF-ET:the rate of embryo implantation was 39.1% in adenomyosis group and 35.8% in control group. The rate of clinical pregnancy was 54.2% in adenomyosis group and 53.7% in control group. The rate of abortion was 4.7% in adenomyosis group and 4.2% in control group. They all did not show statistical differences (P > 0.05). (3) In adenomyosis group, the rate of fertilization, two pronuclear (2PN) and superior embryo were 67.2%(319/475), 60.8% (289/475) and 52.9% (162/306) in patients with failed pregnancy and 74.2% (423/570), 67.7% (386/570) and 62.1% (256/412) in patients with successful pregnancy after IVF-ET, which reached significant difference (P < 0.05).
  
  
  CONCLUSIONS
  Leuprorelin acetate could improve volume of uterine adenomyosis and outcome of pregnancy in patients undergoing IVF-ET.
authors.affiliation: Centre of Medical Reproduction, Ningbo Women and Children's Hospital, Ningbo, China. zhou.li.ming@163.com
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Zhou
authors.forename: Juan
authors.initials: J
authors.lastname: Zheng
authors.forename: Yi-ting
authors.initials: YT
authors.lastname: Sun
authors.forename: Ya-yun
authors.initials: YY
authors.lastname: Zhao
authors.forename: Ai-li
authors.initials: AL
authors.lastname: Xia
mesh_terms: D062788:Adenomyosis / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D016022:Case-Control Studies; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D008863:Microspheres; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome; D014599:Uterus / Q000187:drug effects / Q000473:pathology
chemical_list: D006062:Gonadotropins; D004958:Estradiol; D016729:Leuprolide