title: Residue analyses and exposure assessment of the Irish population to nitrofuran metabolites from different food commodities in 2009-2010.
abstract: An exposure assessment to nitrofuran residues was performed for three human populations (adults, teenagers and children), based on residue analyses of foods of animal origin (liver, honey, eggs and aquaculture) covering the 2-year period 2009-2010. The occurrence of nitrofuran metabolites in food on the Irish market was determined for the selected period using the data from Ireland's National Food Residue Database (NFRD) and from results obtained from the analysis of retail samples (aquaculture and honey). Laboratory analyses of residues were performed by methods validated in accordance with Commission Decision 2002/657/EC regarding performance of the analytical method and interpretation of results. Semicarbazide (SEM) was the contaminant most frequently identified and its content ranged from 0.09 to 1.27 μg kg(-1). SEM is currently used as a marker of nitrofuran abuse, but it may also occur from other sources. The presence of nitrofuran metabolite 3-amino-2-oxazolidinone (AOZ) was detected in two aquaculture samples (prawns) at 1.63 and 1.14 μg kg(-1), but such a low number of positive cases did not present sufficient data for a full AOZ exposure assessment. Therefore, the evaluation of exposure was focused on SEM-containing food groups only. Exposure assessments were completed using a probabilistic approach that generated 10 iterations. The results of both the upper- and lower-bound exposure assessments demonstrate that SEM exposure for Irish adults, teenagers and children from selected food commodities are well below EFSA-estimated safe levels.
authors.affiliation: a Food Safety Department , Teagasc Food Research Centre, Ashtown , Dublin , Ireland.
authors.forename: Anita
authors.initials: A
authors.lastname: Radovnikovic
authors.forename: Emma-Rose
authors.initials: ER
authors.lastname: Conroy
authors.forename: Mike
authors.initials: M
authors.lastname: Gibney
authors.forename: John
authors.initials: J
authors.lastname: O'Mahony
authors.forename: Martin
authors.initials: M
authors.lastname: Danaher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D017756:Aquaculture; D002648:Child; D002675:Child, Preschool; D004350:Drug Residues / Q000032:analysis*; D004531:Eggs / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis*; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D006722:Honey / Q000032:analysis; D006801:Humans; D007494:Ireland; D008099:Liver / Q000737:chemistry; D008460:Meat / Q000032:analysis; D008875:Middle Aged; D009581:Nitrofurans / Q000032:analysis*; D012663:Semicarbazides / Q000032:analysis; D012758:Shellfish / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D009581:Nitrofurans; D012663:Semicarbazides; C010059:carbamylhydrazine