title: DDT/DDE and breast cancer: a meta-analysis.
abstract: The biological basis for investigating dichlorodiphenyltrichloroethane (DDT) exposure and breast cancer risk stems from in vitro and animal studies indicating that DDT has estrogenic properties. The objective of this study was to update a meta-analysis from 2004 which found no association between dichlorodiphenyldichloroethylene (DDE) and breast cancer. We searched PubMed and Web of Science for studies published through June 2012 assessing DDT/DDE exposure and breast cancer. Summary Odds Ratios (ORs) with 95% confidence intervals (CIs) were calculated for the prevalence of breast cancer in the highest versus the lowest exposed groups for DDT and DDE. Difference of means of exposure for cases versus controls was analyzed for DDT and DDE. From the 500 studies screened, 46 were included in the meta-analysis. Slightly elevated, but not statistically significant summary ORs were found for DDE (1.05; 95% CI: 0.93-1.18) and DDT (1.02; 95% CI: 0.92-1.13). Lipid adjusted difference of means analysis found a significantly higher DDE concentration in cases versus controls (11.30 ng/g lipid; p=0.01). No other difference of means analysis found significant relationships. The existing information does not support the hypothesis that exposure to DDT/DDE increases the risk of breast cancer in humans.
authors.affiliation: Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA.
authors.forename: Susan Z
authors.initials: SZ
authors.lastname: Ingber
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Buser
authors.forename: Hana R
authors.initials: HR
authors.lastname: Pohl
authors.forename: Henry G
authors.initials: HG
authors.lastname: Abadin
authors.forename: H Edward
authors.initials: HE
authors.lastname: Murray
authors.forename: Franco
authors.initials: F
authors.lastname: Scinicariello
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology; D003633:Dichlorodiphenyl Dichloroethylene / Q000633:toxicity*; D003632:Dichlorodiphenyldichloroethane / Q000633:toxicity*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D003632:Dichlorodiphenyldichloroethane
keywords: Breast cancer; DDE; DDT; Meta-analysis; Systematic review
references.citation: Cancer Causes Control. 2004 Aug;15(6):591-600
references.pmid: 15280638
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271-7
references.pmid: 10750665
references.citation: Lancet. 2003 Jun 28;361(9376):2205-6
references.pmid: 12842376
references.citation: J Expo Sci Environ Epidemiol. 2007 Jul;17(4):388-99
references.pmid: 17033681
references.citation: Environ Res. 2003 Jun;92(2):110-7
references.pmid: 12854690
references.citation: Occup Environ Med. 2003 May;60(5):348-51
references.pmid: 12709520
references.citation: Int J Cancer. 2006 Nov 1;119(9):2007-25
references.pmid: 16823839
references.citation: Cancer Res. 1997 Sep 1;57(17):3728-32
references.pmid: 9288780
references.citation: Bull Environ Contam Toxicol. 2005 Oct;75(4):752-9
references.pmid: 16400557
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):55-63
references.pmid: 10667464
references.citation: Chem Biol Interact. 2009 Aug 14;180(3):485-91
references.pmid: 19422813
references.citation: Annu Rev Public Health. 1997;18:211-44
references.pmid: 9143718
references.citation: Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):525-32
references.pmid: 10385143
references.citation: Cancer Causes Control. 2000 Feb;11(2):177-84
references.pmid: 10710203
references.citation: BMJ. 1997 Jul 12;315(7100):81-5
references.pmid: 9240045
references.citation: Environ Res. 2000 Oct;84(2):151-61
references.pmid: 11068929
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Jun;7(6):489-96
references.pmid: 9641493
references.citation: Environ Health Perspect. 2007 Oct;115(10):1406-14
references.pmid: 17938728
references.citation: Cancer Causes Control. 2007 Feb;18(1):29-39
references.pmid: 17186420
references.citation: Eur J Cancer Prev. 1998 Apr;7(2):135-40
references.pmid: 9818775
references.citation: Environ Res. 2011 Apr;111(3):337-47
references.pmid: 21295777
references.citation: J Natl Cancer Inst. 1994 Feb 2;86(3):232-4
references.pmid: 8283497
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14
references.pmid: 16896041
references.citation: Biometrics. 1994 Dec;50(4):1088-101
references.pmid: 7786990
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):167-74
references.pmid: 10698477
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):161-6
references.pmid: 10698476
references.citation: Environ Res. 2005 Jun;98(2):250-7
references.pmid: 15820732
references.citation: Clin Chem Lab Med. 2004 Feb;42(2):222-7
references.pmid: 15061365
references.citation: Am J Epidemiol. 2000 Aug 15;152(4):363-70
references.pmid: 10968381
references.citation: Cancer Epidemiol Biomarkers Prev. 2002 Aug;11(8):686-97
references.pmid: 12163320
references.citation: Environ Res. 1984 Jun;34(1):24-8
references.pmid: 6426947
references.citation: J Appl Toxicol. 2011 Apr;31(3):270-8
references.pmid: 21480306
references.citation: Cad Saude Publica. 1998;14 Suppl 3:125-32
references.pmid: 9819471
references.citation: J Natl Cancer Inst. 2001 May 16;93(10):768-76
references.pmid: 11353787
references.citation: Breast Cancer Res Treat. 2005 Mar;90(1):55-64
references.pmid: 15770527
references.citation: Int J Cancer. 2001 Feb 15;91(4):568-74
references.pmid: 11251983
references.citation: Sci Total Environ. 2008 Sep 1;402(2-3):176-83
references.pmid: 18555519
references.citation: Arch Environ Contam Toxicol. 1997 Nov;33(4):453-6
references.pmid: 9419265
references.citation: Lancet Oncol. 2012 Nov;13(11):1141-51
references.pmid: 23084519
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1700-12
references.pmid: 17855685
references.citation: Cancer Causes Control. 1999 Feb;10(1):1-11
references.pmid: 10334636
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1241-9
references.pmid: 11097233
references.citation: Cancer Causes Control. 2009 Jul;20(5):567-80
references.pmid: 19031103
references.citation: Int J Circumpolar Health. 2006 Feb;65(1):18-27
references.pmid: 16544644
references.citation: Arch Environ Contam Toxicol. 1998 Jul;35(1):140-7
references.pmid: 9601932
references.citation: Int J Epidemiol. 1999 Apr;28(2):179-88
references.pmid: 10342677
references.citation: J Hazard Mater. 2002 Jan 4;89(1):41-8
references.pmid: 11734345
references.citation: J Natl Cancer Inst. 1994 Apr 20;86(8):589-99
references.pmid: 8145274
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: J Expo Anal Environ Epidemiol. 2003 Jul;13(4):267-75
references.pmid: 12923553
references.citation: Environ Int. 2002 Nov;28(5):331-6
references.pmid: 12437282
references.citation: Int J Cancer. 1999 Nov 26;83(5):596-600
references.pmid: 10521792
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1233-40
references.pmid: 11097232
references.citation: Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):181-8
references.pmid: 9521429
references.citation: Environ Health Perspect. 2001 Mar;109 Suppl 1:35-47
references.pmid: 11250804
references.citation: Environ Health Perspect. 1999 Jan;107(1):75-81
references.pmid: 9872720
references.citation: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2010;45(3):305-12
references.pmid: 20390871
references.citation: Environ Health. 2012 Apr 25;11:28
references.pmid: 22534004
references.citation: J Natl Cancer Inst. 2000 May 3;92(9):750-3
references.pmid: 10793112
references.citation: J Natl Cancer Inst. 1993 Apr 21;85(8):648-52
references.pmid: 8468722
references.citation: N Engl J Med. 1997 Oct 30;337(18):1253-8
references.pmid: 9345073
references.citation: Mol Endocrinol. 2006 Sep;20(9):2141-55
references.pmid: 16613991
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):67-74
references.pmid: 15668478
references.citation: Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1357-67
references.pmid: 11142422
references.citation: Environ Health Perspect. 2004 Feb;112(2):207-14
references.pmid: 14754575
references.citation: Adv Exp Med Biol. 1999;472:57-66
references.pmid: 10736616
references.citation: Chemosphere. 2004 Mar;54(10):1509-20
references.pmid: 14659953
references.citation: Occup Environ Med. 2005 Dec;62(12):878-84
references.pmid: 16299097
references.citation: Am J Epidemiol. 1999 Sep 1;150(5):453-8
references.pmid: 10472944
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120