title: Exercise-mediated changes in high-density lipoprotein: impact on form and function.
abstract: The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes.
authors.affiliation: Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH.
authors.forename: Alisa
authors.initials: A
authors.lastname: Blazek
authors.forename: Jessica
authors.initials: J
authors.lastname: Rutsky
authors.forename: Kwame
authors.initials: K
authors.lastname: Osei
authors.forename: Andrei
authors.initials: A
authors.lastname: Maiseyeu
authors.forename: Sanjay
authors.initials: S
authors.lastname: Rajagopalan
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL