title: Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy.
abstract: We hypothesized that mobilized peripheral blood stem cells (PBSCs) could be useful for treating neurological impairments and therefore assessed the safety of administering G-CSF followed by collecting PBSC in children with cerebral palsy (CP). G-CSF (10 μg/kg/day) was administered subcutaneously for 5 days, and apheresis was performed to collect PBSC via central venous catheter. G-CSF-related events occurred in 3 patients (fever in 2, irritability in 1). No catheter-related complications were reported. None of the patients needed platelet transfusion or calcium replacement during apheresis. Mobilization with G-CSF followed by PBSC collection appears to be safe and feasible in CP children.
authors.affiliation: Department of Pediatrics, Hanyang University Medical Center, Guri, Gyeonggi-do, South Korea.
authors.forename: Jin-Hwa
authors.initials: JH
authors.lastname: Moon
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Soon-Young
authors.initials: SY
authors.lastname: Song
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yun Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002547:Cerebral Palsy / Q000097:blood* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000009:adverse effects; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D008297:Male; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor
keywords: Apheresis; Cerebral palsy; G-CSF; Peripheral blood stem cell