title: Diagnosis and management of primary hyperparathyroidism--a scientific statement from the Department of Bone Metabolism, the Brazilian Society for Endocrinology and Metabolism.
abstract: OBJECTIVE
  To conduct a literature review on the diagnosis and management of primary hyperparathyroidism including the classical hipercalcemic form as well as the normocalcemic variant.
  
  
  METHODS
  This scientific statement was generated by a request from the Brazilian Medical Association (AMB) to the Brazilian Society for Endocrinology as part of its Clinical Practice Guidelines program. Articles were identified by searching in PubMed and Cochrane databases as well as abstracts presented at the Endocrine Society, Brazilian Society for Endocrinology Annual Meetings and the American Society for Bone and Mineral Research Annual Meeting during the last 5 years. Grading quality of evidence and strength of recommendation were adapted from the first report of the Oxford Centre for Evidence-based Medicine. All grades of recommendation, including "D", are based on scientific evidence. The differences between A, B, C and D, are due exclusively to the methods employed in generating evidence.
  
  
  CONCLUSIONS
  We present a scientific statement on primary hyperparathyroidism providing the level of evidence and the degree of recommendation regarding causes, clinical presentation as well as surgical and medical treatment.
authors.forename: Francisco
authors.initials: F
authors.lastname: Bandeira
authors.forename: Luiz
authors.initials: L
authors.lastname: Griz
authors.forename: Narriane
authors.initials: N
authors.lastname: Chaves
authors.forename: Nara Crispim
authors.initials: NC
authors.lastname: Carvalho
authors.forename: Lívia Maria
authors.initials: LM
authors.lastname: Borges
authors.forename: Marise
authors.initials: M
authors.lastname: Lazaretti-Castro
authors.forename: Victoria
authors.initials: V
authors.lastname: Borba
authors.forename: Luiz Cláudio de
authors.initials: LC
authors.lastname: Castro
authors.forename: João Lindolfo
authors.initials: JL
authors.lastname: Borges
authors.forename: John
authors.initials: J
authors.lastname: Bilezikian
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D010280:Parathyroid Glands / Q000473:pathology / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000592:standards*
chemical_list: D010281:Parathyroid Hormone