title: Structural and functional changes of the coronary arteries in elderly senile patients with essential hypertension.
abstract: The aim of this study was to evaluate the effect of aging on the changes to the structure and function of coronary arteries in senile elderly patients with essential hypertension. Patients (aged 60-80 years) were divided into three groups. The 195 hypertensive patients were divided into four sub-groups according to the duration of hypertension. The changes to the coronary arteries (left and right) of all those patients were tested using the following index by 64 coronary computed tomography (CT) scans. The 24 h systolic blood pressure (SBP) and other blood biochemical parameters were assayed for all patients. We found that the value of the body mass index (BMI), total cholesterol (TC) and low density lipoproteins (LDL) were lower, but age and high density lipoproteins (HDL) were higher in the group of very elderly patients with hypertension (Group I; P<0.05) compared with those of a group of elderly patients with hypertension (Group III). The left anterior descending branch calcification score (CSLAD), total calcification score (CST), pulse pressure (PP), the left main branch calcification score (CSLM), the left circumflex branch calcification score (CSLCX) were significantly increased in Group I compared with Group III (P<0.01 and P<0.05, respectively). In addition, the 24 h SBP value for Group I was higher than in the 'very elderly without hypertension' group (Group II). Hence, in elderly patients, a decrease in the levels of BMI, HDL, TC and LDL accompanies aging. Furthermore, the decline of arterial compliance and increase in arterial stiffness develops with age. Aging is more likely to lead to atherosclerosis in the coronary arteries, particularly in the left main coronary artery and its main branches. Aging is an uncontrollable risk factor, which plays a crucial role in coronary artery atherosclerosis.
authors.affiliation: Geriatric Department, Xuhui Central Hospital, Shanghai 200031, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Fu
authors.initials: F
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Xinhai
authors.initials: X
authors.lastname: Cheng
authors.forename: Guiyu
authors.initials: G
authors.lastname: Chen
authors.forename: Haifen
authors.initials: H
authors.lastname: Tai
authors.forename: Shaohua
authors.initials: S
authors.lastname: Fan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001794:Blood Pressure; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000209:etiology / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D000075222:Essential Hypertension; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors