title: Transcriptional regulation at the yeast nuclear envelope.
abstract: The spatial organization of the genome inside the nucleus affects many nuclear processes, such as DNA replication, DNA repair, and gene transcription. In metazoans, the nuclear periphery harbors mainly repressed genes that associate with the nuclear lamina. This review discusses how peripheral positioning is connected to transcriptional regulation in yeasts. Tethering of reporter genes to the nuclear envelope was found to result in transcriptional silencing. Similarly, repression of the silent mating type loci and subtelomeric genes is influenced by their position close to the nuclear envelope. In contrast, active genes are bound by nucleoporins and inducible genes associate with the nuclear pore complex upon activation. Taken together, these results portray the nuclear envelope as a platform for transcriptional regulation, both through activation at nuclear pores and silencing at the nuclear envelope.
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences; Karolinska Institutet; Huddinge, Sweden; Verna and Marrs McLean Department of Biochemistry and Molecular Biology; Baylor College of Medicine; Houston, TX USA; Department of Molecular and Cellular Biology; Baylor College of Medicine; Houston, TX USA.
authors.forename: Babett
authors.initials: B
authors.lastname: Steglich
authors.forename: Shelley
authors.initials: S
authors.lastname: Sazer
authors.forename: Karl
authors.initials: K
authors.lastname: Ekwall
mesh_terms: D000818:Animals; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal / Q000235:genetics; D006801:Humans; D009685:Nuclear Envelope / Q000235:genetics*; D016615:Telomere / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*; D015003:Yeasts / Q000166:cytology* / Q000235:genetics*
keywords: heterochromatin; nuclear envelope; nuclear pore complex; telomeres; transcriptional regulation
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