title: Therapy choices and quality of life in young breast cancer survivors: a short-term follow-up.
abstract: BACKGROUND
  Premenopausal women represent approximately 35% of new breast cancer diagnoses. Diagnosis and treatment may lead to substantial disruption in quality of life (QOL).
  
  
  METHODS
  Premenopausal patients (aged 18 to 50 years) treated for nonmetastatic breast cancer completed a mailed questionnaire. Multiple self-reported QOL measures and clinical data were collected. Cluster analysis and Cronbach's α were used to validate the survey. Analysis of variance was performed for specific interventions. Lower interference scores conveyed higher QOL.
  
  
  RESULTS
  The response rate was 49.8%. Cronbach's α was 0.96. Immediate contralateral prophylactic mastectomy (CPM) carried the highest interference (mean, 3.3148) with sexuality compared with no CPM (mean, 2.85) or delayed CPM (P = .03). Breast conservation had the least interference with appearance (P < .01) and work and finances (P = .02).
  
  
  CONCLUSIONS
  Therapeutic mastectomy and CPM with or without reconstruction may adversely affect QOL. These findings suggest that the choice and timing of interventions may significantly affect patient satisfaction.
authors.affiliation: Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Electronic address: m.catherine.lee@moffitt.org.
authors.forename: Marie Catherine
authors.initials: MC
authors.lastname: Lee
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Bhati
authors.forename: Edina E
authors.initials: EE
authors.lastname: von Rottenthaler
authors.forename: Angela M
authors.initials: AM
authors.lastname: Reagan
authors.forename: Sloan B
authors.initials: SB
authors.lastname: Karver
authors.forename: Richard R
authors.initials: RR
authors.lastname: Reich
authors.forename: Gwendolyn P
authors.initials: GP
authors.lastname: Quinn
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy / Q000523:psychology; D015412:Mastectomy, Segmental / Q000523:psychology; D008875:Middle Aged; D017697:Premenopause; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D015203:Reproducibility of Results; D019529:Sexuality; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Breast cancer; Premenopausal; Prophylactic mastectomy; Quality of life
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