title: Expression of cytotoxic T-lymphocyte antigen 4 on CD4+ and CD8+ T cells is increased in acute lung injury.
abstract: Acute lung injury (ALI) is a severe form of diffuse lung disease, which imposes a substantial health burden all over the world. The immune system plays a key role in the development of ALI. The aim of the study was to investigate the expression of cytotoxic T-lymphocyte antigen 4 (CTLA4) in ALI. Levels of CTLA4 were tested on CD4+ and CD8+ T cells in 62 ALI cases and 75 healthy controls by flow cytometry. Data revealed that prevalence of CTLA4 on CD4+ T cells was significantly increased in ALI patients (3.7%±2.1%) than in controls (0.7%±0.3%). Similarly, the proportion of CTLA4 on CD8+ T cells was also significantly elevated in cases (1.0%±0.4% versus 0.5%±0.1%, p<0.05). Further analysis showed that the frequency of CTLA4+CD4+ T cells was positively correlated with the score of Acute Physiology and Chronic Health Evaluation II (APACHE II) (p=0.0005). In addition, when investigating CTLA4 expression with ALI patient mortality, we observed that the level of CTLA4+CD4+ T cells in patients was higher at the time before death than at the time of recruitment (p=0.001). These data suggested that CTLA4 was involved in the pathogenesis and progression of ALI and could be used as a potential target for treating this disease.
authors.affiliation: 1 School of Occupational Therapy, University of Western Ontario , London, Ontario, Canada .
authors.forename: Yujia
authors.initials: Y
authors.lastname: Zhou
authors.forename: Lunxian
authors.initials: L
authors.lastname: Tang
authors.forename: Minjia
authors.initials: M
authors.lastname: Lin
authors.forename: Shumin
authors.initials: S
authors.lastname: Xu
authors.forename: Jianwen
authors.initials: J
authors.lastname: Bai
authors.forename: Haihan
authors.initials: H
authors.lastname: Song
mesh_terms: D055371:Acute Lung Injury / Q000401:mortality / Q000503:physiopathology*; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D060908:CTLA-4 Antigen / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking
chemical_list: D060908:CTLA-4 Antigen