title: Oxaliplatin induced-neuropathy in digestive tumors.
abstract: Oxaliplatin is one of the main drugs used in digestive tumors treatment. Peripheral neuropathy is a well-recognized dose-limiting toxicity of OXL. Two types of neuropathy have been described with this agent: acute or transient and chronic or persistent, with different etiology, clinical manifestations and prognosis. This paper is an exhaustive review about the main aspects of oxaliplatin induced peripheral neuropathy, focus in clinical features, treatment, prevention strategies and future approach.
authors.affiliation: Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain. Electronic address: mariasereno75@gmail.com.
authors.forename: María
authors.initials: M
authors.lastname: Sereno
authors.affiliation: Neurologist, Neuromuscular Unit, Neurology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gutiérrez-Gutiérrez
authors.affiliation: Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Gómez-Raposo
authors.affiliation: Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: López-Gómez
authors.affiliation: Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Merino-Salvador
authors.affiliation: Medical Oncologist, Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: Francisco Zambrana
authors.initials: FZ
authors.lastname: Tébar
authors.affiliation: National Center in Oncology Research, Madrid 28015, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rodriguez-Antona
authors.affiliation: Medical Oncologist, Chief of Medical Oncology Department, Infanta Sofía University Hospital, San Sebastian de los Reyes, Madrid 28702, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Casado
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004067:Digestive System Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: Digestive tumors; Oxaliplatin; Peripheral neuropathy