title: Brd4 shields chromatin from ATM kinase signaling storms.
abstract: Upon activation, ataxia telangiectasia mutated (ATM) kinase rapidly phosphorylates hundreds of proteins, setting off chaotic signaling storms from areas of damaged chromatin. Recent work by Kaidi and Jackson and Floyd et al. advance our knowledge of the mechanisms that initiate or limit ATM kinase signaling storms at chromatin.
authors.affiliation: 1UPMC Medical Education Transitional Year Residency Program, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Pittsburgh, PA 15213, USA.
authors.forename: Serah
authors.initials: S
authors.lastname: Choi
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bakkenist
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism* / Q000528:radiation effects; D018797:Cell Cycle Proteins; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011839:Radiation, Ionizing; D015398:Signal Transduction / Q000502:physiology* / Q000528:radiation effects; D014157:Transcription Factors / Q000378:metabolism*; D000092468:Bromodomain Containing Proteins
chemical_list: D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D002843:Chromatin; D009687:Nuclear Proteins; D014157:Transcription Factors; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins
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