title: Some optimal culture conditions for production of cyclosporin a by Fusarium roseum.
abstract: A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO3, 2; KH2PO4, 1; MgSO4.7H2O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.
authors.affiliation: Department of Botany, Faculty of Science, Zagazig University , Zagazig Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Ismaiel
authors.forename: A
authors.initials: A
authors.lastname: El-Sayed
authors.forename: Asmaa A
authors.initials: AA
authors.lastname: Mahmoud
keywords: Cyclosporin A; Fermentation conditions; Fusarium roseum
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