title: Ultrabright organic dots with aggregation-induced emission characteristics for real-time two-photon intravital vasculature imaging.
abstract: Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.forename: Chi Ching
authors.initials: CC
authors.lastname: Goh
authors.forename: Guangxue
authors.initials: G
authors.lastname: Feng
authors.forename: Zujin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Rongrong
authors.initials: R
authors.lastname: Liu
authors.forename: Nikodem
authors.initials: N
authors.lastname: Tomczak
authors.forename: Junlong
authors.initials: J
authors.lastname: Geng
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.forename: Lai Guan
authors.initials: LG
authors.lastname: Ng
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000792:Angiography; D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D017785:Photons; D012867:Skin / Q000000981:diagnostic imaging; D019265:Spectroscopy, Near-Infrared; D013830:Thiadiazoles / Q000737:chemistry*; D059008:Time-Lapse Imaging
chemical_list: D003287:Contrast Media; D013830:Thiadiazoles
keywords: aggregation-induced emission; blood vascular imaging; nanoparticles; quantum dots; two-photon fluorescence imaging