title: Serum interleukins 6 and 8 in mild and severe asthmatic patients, is it difference?
abstract: BACKGROUND
  About 5-10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy.
  
  
  METHODS
  21 severe and 30 mild asthma patients were recruited and underwent collection of blood sample. We determined whether there were any differences in inflammatory biomarkers between severe and mild asthma patients or not.
  
  
  RESULTS
  Levels of Interleukin-8 (IL-8) and Interleukin-6 (IL-6) in blood supernatants were similar in both groups of asthma patients. Leukocytes were in range of normal in all patients. Increased eosinophil was in 29% of severe cases and 23% in mild cases. IgE level was increased in 43% of severe form and 50% in mild form.
  
  
  CONCLUSIONS
  There is not any difference between severe and mild asthma in serum IL-8 and IL-6. Therefore, level of serum cytokines may not predict severity of asthma.
authors.affiliation: Molecular cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran ; Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Ghaffari
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Rafiei
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Ajami
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mahdavi
authors.forename: Bahareh
authors.initials: B
authors.lastname: Hoshiar
keywords: Interleukin 6; Interleukin8; Mild asthma; Severe asthma
references.citation: Am J Respir Crit Care Med. 1996 Jul;154(1):224-30
references.pmid: 8680684
references.citation: Int Arch Allergy Immunol. 2000 Jan;121(1):10-8
references.pmid: 10686504
references.citation: Int Rev Immunol. 1998;16(5-6):541-51
references.pmid: 9646176
references.citation: Am J Physiol Cell Physiol. 2006 Nov;291(5):C957-65
references.pmid: 16822944
references.citation: Am J Respir Crit Care Med. 2000 Dec;162(6):2341-51
references.pmid: 11112161
references.citation: Am J Respir Crit Care Med. 1995 May;151(5):1354-8
references.pmid: 7735584
references.citation: J Exp Med. 1996 Jun 1;183(6):2593-603
references.pmid: 8676080
references.citation: Eur Respir J. 1999 May;13(5):1198-208
references.pmid: 10414427
references.citation: J Immunol. 1999 Feb 1;162(3):1246-51
references.pmid: 9973376
references.citation: Eur Respir J. 2003 Dec;22(6):920-5
references.pmid: 14680079
references.citation: Immunol Today. 1998 Jan;19(1):5-9
references.pmid: 9465481
references.citation: Clin Exp Allergy. 1996 Oct;26(10):1210-9
references.pmid: 8911709
references.citation: Eur Respir J. 2006 May;27(5):908-12
references.pmid: 16707391