title: Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.
abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.
authors.affiliation: Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Niemeyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Zillinger
authors.forename: Doreen
authors.initials: D
authors.lastname: Muth
authors.forename: Florian
authors.initials: F
authors.lastname: Zielecki
authors.forename: Gabor
authors.initials: G
authors.lastname: Horvath
authors.forename: Tasnim
authors.initials: T
authors.lastname: Suliman
authors.forename: Winfried
authors.initials: W
authors.lastname: Barchet
authors.forename: Friedemann
authors.initials: F
authors.lastname: Weber
authors.forename: Christian
authors.initials: C
authors.lastname: Drosten
authors.forename: Marcel A
authors.initials: MA
authors.lastname: Müller
mesh_terms: D000595:Amino Acid Sequence; D017934:Coronavirus / Q000254:growth & development / Q000472:pathogenicity*; D018352:Coronavirus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007370:Interferon Type I / Q000037:antagonists & inhibitors*; D008877:Middle East; D008969:Molecular Sequence Data; D012330:RNA, Double-Stranded / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism*
chemical_list: D007370:Interferon Type I; D012330:RNA, Double-Stranded; D054334:Viral Regulatory and Accessory Proteins
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