title: A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors.
abstract: A new paullone-TEMPO conjugate and its copper(II) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.
authors.affiliation: Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria. vladimir.arion@univie.ac.at.
authors.forename: Anatolie
authors.initials: A
authors.lastname: Dobrov
authors.forename: Simone
authors.initials: S
authors.lastname: Göschl
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Ana
authors.initials: A
authors.lastname: Popović-Bijelić
authors.forename: Astrid
authors.initials: A
authors.lastname: Gräslund
authors.forename: Peter
authors.initials: P
authors.lastname: Rapta
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Arion
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001552:Benzazepines / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D057093:Orphan Nuclear Receptors / Q000037:antagonists & inhibitors*; D017382:Reactive Oxygen Species
chemical_list: D000970:Antineoplastic Agents; D001552:Benzazepines; D056831:Coordination Complexes; D003497:Cyclic N-Oxides; D005609:Free Radicals; D008024:Ligands; C403073:NR2E3 protein, human; D057093:Orphan Nuclear Receptors; D017382:Reactive Oxygen Species; C547599:paullone; D003300:Copper; C003959:TEMPO
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