title: The lateral reticular nucleus: a precerebellar centre providing the cerebellum with overview and integration of motor functions at systems level. A new hypothesis.
abstract: The lateral reticular nucleus (LRN) is a major precerebellar centre of mossy fibre information to the cerebellum from the spinal cord that is distinct from the direct spinocerebellar paths. The LRN has traditionally been considered to provide the cerebellum with segregated information from several spinal systems controlling posture, reaching, grasping, locomotion, scratching and respiration. However, results are presented that show extensive convergence on a majority of LRN neurons from spinal systems. We propose a new hypothesis suggesting that the LRN may use extensive convergence from the different input systems to provide overview and integration of linked motor components to the cerebellum. This integrated information is sent in parallel with the segregated information from the individual systems to the cerebellum that finally may compare the activity and make necessary adjustments of various motor behaviours.
authors.affiliation: Professor B. Alstermark: University of Umea, Department of Physiology, S-901 87 Umea, Sweden. bror.alstermark@physiol.umu.se.
authors.forename: Bror
authors.initials: B
authors.lastname: Alstermark
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Ekerot
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D008124:Locomotion / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012154:Reticular Formation / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology
references.citation: J Comp Neurol. 1997 Dec 29;389(4):617-41
references.pmid: 9421143
references.citation: J Physiol. 2013 Feb 15;591(4):1045-62
references.pmid: 23184515
references.citation: Eur J Neurosci. 1996 Oct;8(10):2157-67
references.pmid: 8921307
references.citation: Brain Res. 1978 Aug 11;151(3):493-506
references.pmid: 667627
references.citation: Anat Embryol (Berl). 1979 Apr 6;155(3):273-90
references.pmid: 88191
references.citation: Exp Brain Res. 1990;79(1):120-8
references.pmid: 2311688
references.citation: Exp Brain Res. 1974;21(5):487-500
references.pmid: 4374371
references.citation: J Comp Neurol. 1999 Aug 16;411(1):97-118
references.pmid: 10404110
references.citation: Exp Brain Res. 1974;21(4):419-32
references.pmid: 4374368
references.citation: Exp Brain Res. 1982;47(1):148-50
references.pmid: 6288430
references.citation: Brain Res. 1969 Oct;15(2):556-8
references.pmid: 5344390
references.citation: Brain Res. 1967 Oct;6(2):252-74
references.pmid: 6056711
references.citation: Exp Brain Res. 1974 Jan 22;19(1):1-19
references.pmid: 4591655
references.citation: Brain Res. 1982 Jan 14;231(2):427-32
references.pmid: 6173095
references.citation: Exp Brain Res. 1977 Sep 28;29(3-4):323-46
references.pmid: 913521
references.citation: Anat Embryol (Berl). 1988;177(3):277-83
references.pmid: 3354844
references.citation: Exp Brain Res. 1971;12(3):295-316
references.pmid: 5553375
references.citation: Exp Brain Res. 1976 Feb 26;24(4):403-21
references.pmid: 1261625
references.citation: Exp Brain Res. 1975 Dec 22;24(2):131-44
references.pmid: 176047
references.citation: J Neurophysiol. 2013 Jan;109(2):375-88
references.pmid: 23100134
references.citation: Exp Brain Res. 1990;79(1):129-37
references.pmid: 2311689
references.citation: J Neurosci. 2006 Nov 15;26(46):12067-80
references.pmid: 17108180
references.citation: J Neurophysiol. 1980 Nov;44(5):922-36
references.pmid: 7441323
references.citation: Brain Res. 1978 Aug 11;151(3):479-91
references.pmid: 667626
references.citation: Neurosci Lett. 1978 Feb;7(2-3):167-72
references.pmid: 19605107
references.citation: Exp Brain Res. 1990;79(1):109-19
references.pmid: 2311687
references.citation: Annu Rev Neurosci. 2012;35:559-78
references.pmid: 22524789
references.citation: Exp Brain Res. 1997 Feb;113(2):230-42
references.pmid: 9063709
references.citation: Exp Brain Res. 1981;42(3-4):282-98
references.pmid: 6263663
references.citation: Nat Neurosci. 2010 Oct;13(10):1233-9
references.pmid: 20835249