title: CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice.
abstract: Cell adhesion molecules (CAMs) are crucial effectors for the development and maintenance of the nervous system. Mutations in human CAM genes are linked to brain disorders and psychological diseases, and CAM knockout mice always exhibit similar behavioral abnormalities. CD146 is a CAM of the immunoglobulin superfamily that interacts with Neurite Outgrowth Factor and involved in neurite extension in vitro. However, little is known about its in vivo function in the nervous system. In this study, we used a murine CD146 nervous system knockout (CD146(ns-ko)) model. We found that the brains of some CD146(ns-ko) mice were malformed with small olfactory bulbs. CD146(ns-ko) mice exhibited lower body weights and smaller food intake when compared with wild type littermates. Importantly, behavior tests revealed that CD146(ns-ko) mice exhibited significant decreased locomotor activity and impaired capacity for spatial learning and memory. Our results demonstrate that CD146 is important for mammalian nervous system development and proper behavior patterns.
authors.affiliation: Key Laboratory of Protein and Peptide Pharmaceuticals, CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China ; University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tu
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Yongting
authors.initials: Y
authors.lastname: Luo
authors.forename: Jianan
authors.initials: J
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.forename: Dongling
authors.initials: D
authors.lastname: Yang
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.forename: Xiyun
authors.initials: X
authors.lastname: Yan
mesh_terms: D000818:Animals; D001066:Appetite / Q000235:genetics*; D001522:Behavior, Animal; D001835:Body Weight; D051929:CD146 Antigen / Q000235:genetics*; D017353:Gene Deletion; D023061:Gene Order; D018390:Gene Targeting; D018782:Maze Learning; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics*; D009420:Nervous System / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D009830:Olfactory Bulb / Q000473:pathology; D009929:Organ Size
chemical_list: D051929:CD146 Antigen
references.citation: Annu Rev Nutr. 2006;26:23-44
references.pmid: 16704352
references.citation: Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a001867
references.pmid: 20519341
references.citation: Histochem Cell Biol. 2008 Apr;129(4):441-51
references.pmid: 18214516
references.citation: Neuron. 1994 Apr;12(4):861-72
references.pmid: 8161457
references.citation: J Neurosci. 2000 Feb 15;20(4):1446-57
references.pmid: 10662835
references.citation: Proc Natl Acad Sci U S A. 1989 Dec;86(24):9891-5
references.pmid: 2602381
references.citation: Eur J Neurosci. 2001 Apr;13(7):1391-402
references.pmid: 11298800
references.citation: J Neurosci. 1999 Jun 15;19(12):4907-20
references.pmid: 10366625
references.citation: Neurobiol Dis. 2004 Mar;15(2):387-93
references.pmid: 15006709
references.citation: Int J Mol Med. 2005 Dec;16(6):1009-14
references.pmid: 16273279
references.citation: Dev Biol. 1989 Oct;135(2):272-86
references.pmid: 2776969
references.citation: Hum Pathol. 2007 Jun;38(6):830-41
references.pmid: 17316758
references.citation: Annu Rev Cell Dev Biol. 1997;13:425-56
references.pmid: 9442880
references.citation: PLoS One. 2012;7(9):e46223
references.pmid: 23049984
references.citation: J Biol Chem. 2004 Jul 9;279(28):28880-8
references.pmid: 15128735
references.citation: J Cell Physiol. 2004 Mar;198(3):377-87
references.pmid: 14755543
references.citation: Anal Cell Pathol. 2003;25(2):77-81
references.pmid: 12632016
references.citation: J Cell Physiol. 2005 Aug;204(2):632-7
references.pmid: 15880440
references.citation: Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6861-5
references.pmid: 1495975
references.citation: Mol Psychiatry. 2002;7(4):412-5
references.pmid: 11986985
references.citation: Hybridoma (Larchmt). 2008 Oct;27(5):345-52
references.pmid: 18847347
references.citation: PLoS One. 2011;6(8):e23433
references.pmid: 21887252
references.citation: Neuron. 2002 Aug 15;35(4):625-41
references.pmid: 12194864
references.citation: FEBS Lett. 2003 Nov 20;554(3):311-4
references.pmid: 14623085
references.citation: Nature. 2012 Nov 15;491(7424):357-63
references.pmid: 23151578
references.citation: Nat Genet. 1997 Nov;17(3):346-9
references.pmid: 9354804
references.citation: Hum Mol Genet. 1998 Jun;7(6):999-1009
references.pmid: 9580664
references.citation: J Neurosci. 1999 Nov 1;19(21):9469-79
references.pmid: 10531450
references.citation: Gene. 2001 Nov 14;279(1):17-31
references.pmid: 11722842
references.citation: Neuroimmunomodulation. 1998 Sep-Oct;5(5):270-6
references.pmid: 9730695
references.citation: Eur J Hum Genet. 1995;3(5):273-84
references.pmid: 8556302
references.citation: Nature. 1994 Feb 3;367(6462):455-9
references.pmid: 8107803
references.citation: J Neurosci Res. 1998 Jul 15;53(2):129-34
references.pmid: 9671969
references.citation: Neuron. 1999 Jun;23(2):209-26
references.pmid: 10399928
references.citation: J Pathol. 1999 Sep;189(1):4-11
references.pmid: 10451481
references.citation: J Neurosci. 2010 Aug 11;30(32):10784-98
references.pmid: 20702708
references.citation: Blood. 2003 Jul 1;102(1):184-91
references.pmid: 12609848
references.citation: Nat Neurosci. 2007 Jan;10(1):19-26
references.pmid: 17189949
references.citation: Biotechnol J. 2008 Dec;3(12):1564-80
references.pmid: 19072911