title: Acute generalised exanthematous pustulosis induced by Pneumocystis jirovecii pneumonia prophylaxis with dapsone.
abstract: We describe the case of HIV-1 infected patient presenting to hospital with a severe cutaneous adverse drug reaction shortly after commencing dapsone therapy as Pneumocystis jirovecii pneumonia prophylaxis. To the best of our knowledge, acute generalised exanthematous pustulosis has not been reported as a reaction to dapsone in the setting of HIV.
authors.affiliation: Manchester Centre for Sexual Health and HIV, Manchester Royal Infirmary, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Vas
authors.forename: P
authors.initials: P
authors.lastname: Laws
authors.forename: Am
authors.initials: A
authors.lastname: Marsland
authors.forename: O
authors.initials: O
authors.lastname: McQuillan
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D056150:Acute Generalized Exanthematous Pustulosis / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D001706:Biopsy; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D003622:Dapsone
keywords: AIDS; HIV; acute generalised exanthematous pustulosis; antiretroviral therapy; dapsone; drug reaction; toxicity