title: Multivariate classification of blood oxygen level-dependent FMRI data with diagnostic intention: a clinical perspective.
abstract: There has been a recent upsurge of reports about applications of pattern-recognition techniques from the field of machine learning to functional MR imaging data as a diagnostic tool for systemic brain disease or psychiatric disorders. Entities studied include depression, schizophrenia, attention deficit hyperactivity disorder, and neurodegenerative disorders like Alzheimer dementia. We review these recent studies which-despite the optimism from some articles-predominantly constitute explorative efforts at the proof-of-concept level. There is some evidence that, in particular, support vector machines seem to be promising. However, the field is still far from real clinical application, and much work has to be done regarding data preprocessing, model optimization, and validation. Reporting standards are proposed to facilitate future meta-analyses or systematic reviews.
authors.affiliation: From the Department of Clinical Radiology (B.S., W.S., B.P.), University Hospital Münster, Münster, Germany benedikt.sundermann@ukmuenster.de.
authors.forename: B
authors.initials: B
authors.lastname: Sundermann
authors.affiliation: Department of Psychiatry and Psychotherapy (D.H.), University of Cologne, Cologne, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Herr
authors.affiliation: From the Department of Clinical Radiology (B.S., W.S., B.P.), University Hospital Münster, Münster, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Schwindt
authors.affiliation: From the Department of Clinical Radiology (B.S., W.S., B.P.), University Hospital Münster, Münster, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Pfleiderer
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology; D019317:Evidence-Based Medicine; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015999:Multivariate Analysis; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*
chemical_list: D010100:Oxygen
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