title: [Association between high-sensitivity C-reactive protein and contrast-induced nephropathy after primary percutaneous coronary intervention].
abstract: OBJECTIVE
  To explore the association between high-sensitivity C-reactive protein (hs-CRP) and contrast-induced nephropathy (CIN) in patients with ST-segment elevated myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) .
  
  
  METHODS
  A total of 220 STEMI patients undergoing primary PCI from Guangdong general hospital were recruited. Patients were divided into four groups according to the quartile of hs-CRP (Q1 group:hs-CRP < 6.26 mg/L,Q2 group:6.26-14.44 mg/L, Q3 group:14.45-33.08 mg/L, Q4 group:hs-CRP > 33.08 mg/L) . Baseline data, CIN incidence and other in-hospital outcomes were compared among groups. CIN was defined as an increase in serum creatinine of more than 5 mg/L from baseline within 48-72 hours after contrast media exposure. Receiver operator characteristics (ROC) curves and multivariate logistic regression were used to assessed the correlation between hs-CRP and CIN.
  
  
  RESULTS
  CIN occurred in 21 (9.8%) patients. CIN incidence of hs-CRP quartitles were 1.8%(1/55), 1.8% (1/55), 14.5% (8/55) and 20.0% (11/55) (P-trend < 0.01), respectively. In-hospital death (P-trend > 0.05) , required renal replace therapy (P-trend > 0.05) were similar among groups. ROC analysis revealed that the optimal cutoff value of hs-CRP to predict the onset of CIN was 16.85 mg/L (sensitivity: 81.0%, specificity: 61.8%, AUC: 0.748). Univariate logistic analysis showed that hs-CRP was strongly related with CIN incidence (OR = 6.88,95%CI:2.23-21.21, P < 0.01). Multivariate logistic regression analysis showed that after adjusting other traditional risk factors including female gender, anemia, ACEI/ARB use, IABP support, LVEF < 40%, age > 75 years, baseline eGFR and diabetes, hs-CRP > 16.85 mg/L was still a significant independent predictor of CIN in patients with STEMI undergoing primary PCI. Additionally, age > 75 years (OR = 7.27,95%CI:1.85-28.63, P < 0.01), eGFR (OR = 6.38,95% CI:1.48-27.41, P < 0.05) were also independent risk factors of CIN.
  
  
  CONCLUSIONS
  hs-CRP is positively correlated with CIN incidence. STEMI patients with higher hs-CRP level post PCI is at higher risk of developing CIN.
authors.affiliation: Department of Cardiology, Guangdong Academy of Medical Sciences, Guangzhou, China.
authors.forename: Yi-ting
authors.initials: YT
authors.lastname: He
authors.forename: Ning
authors.initials: N
authors.lastname: Tan
authors.forename: Yuan-hui
authors.initials: YH
authors.lastname: Liu
authors.forename: Si-qun
authors.initials: SQ
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Shui-jin
authors.initials: SJ
authors.lastname: Huang
authors.forename: Da-hao
authors.initials: DH
authors.lastname: Yang
authors.forename: Piao
authors.initials: P
authors.lastname: Ye
authors.forename: Peng
authors.initials: P
authors.lastname: Ran
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D012372:ROC Curve
chemical_list: D003287:Contrast Media; D002097:C-Reactive Protein