title: Profiling human Src homology 2 (SH2) domain proteins and ligand discovery using a peptide-hybrid small molecule microarray.
abstract: A 396-member peptide-hybrid small molecule microarray was fabricated to profile small molecule ligands across 15 SH2 proteins, revealing hits against Lck and Grb2.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmyaosq@nus.edu.sg.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Fu
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Na
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D051380:GRB2 Adaptor Protein / Q000378:metabolism; D006801:Humans; D008024:Ligands; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D040081:Protein Array Analysis; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D018909:src Homology Domains
chemical_list: D051380:GRB2 Adaptor Protein; D008024:Ligands; D010455:Peptides; D054852:Small Molecule Libraries; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)