title: Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients.
abstract: BACKGROUND
  A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD.
  
  
  METHODS
  LDL and HDL subclasses were analysed in 100 stable angina patients with ≥50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography.
  
  
  RESULTS
  Patients with <50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P < 0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P < 0.05, respectively).
  
  
  CONCLUSIONS
  Stable angina patients with <50% of coronary obstruction have more favourable HDL subclasses distribution than patients with significant coronary stenosis.
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zeljkovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Vekic
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojevic-Kalimanovska
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelic-Ivanovic
authors.forename: Dimitra
authors.initials: D
authors.lastname: Kalimanovska-Ostric
authors.forename: Lidija
authors.initials: L
authors.lastname: Memon
authors.forename: Natasa
authors.initials: N
authors.lastname: Bogavac-Stanojevic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Topic
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasic
mesh_terms: D060050:Angina, Stable / Q000097:blood*; D003324:Coronary Artery Disease; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010316:Particle Size
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL
keywords: LDL and HDL subclasses; central adiposity; dyslipidemia; non-obstructive coronary artery disease