title: Single pulse TMS differentially modulates reward behavior.
abstract: Greater knowledge of cortical brain regions in reward processing may set the stage for using transcranial magnetic stimulation (TMS) as a treatment in patients with avolition, apathy or other drive-related symptoms. This study examined the effects of single pulse (sp) TMS to two reward circuit targets on drive in healthy subjects. Fifteen healthy subjects performed the monetary incentive delay task (MID) while receiving fMRI-guided spTMS to either inferior parietal lobe (IPL) or supplemental motor area (SMA). The study demonstrated decreasing reaction times (RT) for increasing reward. It also showed significant differences in RT modulation for TMS pulses to the IPL versus the SMA. TMS pulses during the delay period produced significantly more RT slowing when targeting the IPL than those to the SMA. This RT slowing carried over into subsequent trials without TMS stimulation, with significantly slower RTs in sessions that had targeted the IPL compared to those targeting SMA. The results of this study suggest that both SMA and IPL are involved in reward processing, with opposite effects on RT in response to TMS stimulation. TMS to these target cortical regions may be useful in modulating reward circuit deficits in psychiatric populations.
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Institute for the Neurosciences, Room 117, Boston, MA 02115, USA. Electronic address: astanford1@partners.org.
authors.forename: Arielle D
authors.initials: AD
authors.lastname: Stanford
authors.forename: Bruce
authors.initials: B
authors.lastname: Luber
authors.forename: Layla
authors.initials: L
authors.lastname: Unger
authors.forename: Yael M
authors.initials: YM
authors.lastname: Cycowicz
authors.forename: Dolores
authors.initials: D
authors.lastname: Malaspina
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Lisanby
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Brain stimulation; Inferior parietal lobe; Monetary incentive delay task; Motivation; Supplementary motor area; TMS; fMRI