title: The relationship between neutrophil-to-lymphocyte ratio and coronary collateral circulation.
abstract: Neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker to determine systemic inflammatory response and atherosclerosis. Our aim was to determine the relationship between NLR and development of coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD). A total of 521 consecutive patients with stable CAD who underwent coronary angiography and documented total occlusion in one of those major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell, and NLR were significantly higher in patients with poor collateral than in those with good collateral. After multivariate analysis, high level of NLR was an independent predictor of CCC together with levels of fasting blood glucose. The receiver-operating characteristic analysis provided a cutoff value of 2.75 for NLR to predict poor CCC with 65% sensitivity and 68% specificity. We demonstrated an independent association between levels of NLR and development of CCC in patients with stable CAD.
authors.affiliation: Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey onurkadir@gmail.com.
authors.forename: Onur Kadir
authors.initials: OK
authors.lastname: Uysal
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Turkoglu
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Durmus Yildiray
authors.initials: DY
authors.lastname: Sahin
authors.affiliation: Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Arafat
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Bugra
authors.initials: B
authors.lastname: Ozkan
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Tekin
authors.affiliation: Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Aysegul Ulgen
authors.initials: AU
authors.lastname: Kunak
authors.affiliation: Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Yilmaz
authors.affiliation: Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gur
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Cayli
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011237:Predictive Value of Tests
chemical_list: D001786:Blood Glucose
keywords: atherosclerosis; cardiology; endothelial dysfunction