title: The current status of lymph node dissection in the treatment of papillary thyroid cancer. A literature review.
abstract: OBJECTIVE
  Cervical lymph node micrometastases are observed in up to 90% of papillary thyroid cancers (PTC), showing that lymph nodal involvement is very common. Nevertheless, during the last years, the role of lymph node dissection in the treatment of PTC has been controversial and, at present, the best indications to the routine or therapeutic neck dissection remain subject of research. In order to better analyze the current role of lymph node dissection in the surgical treatment of PTC, an analysis of the most recent literature data was performed.
  
  
  METHODS
  By using as keywords lymph node dissection, selective, lateral or central lymph node dissection, modified radical neck dissection, prophylactic or therapeutic lymph node dissection, papillary thyroid cancer, a Pub Med data base research was carried out. The most recent guidelines of different referral endocrine societies, inhering neck dissection for PTC, were also evaluated.
  
  
  RESULTS
  The role of neck dissection in PTC management remains controversial regarding routine or therapeutic indications, surgical extension, and its impact on local recurrence and long term survival. Due to inhomogeneous literature data, the current status of node dissection is still subject of research.
  
  
  CONCLUSIONS
  There is agreement between endocrine and neck surgeons about the extension of therapeutic lymph node dissection in N+ PTC patients , and also in the prophylactic treatment of N0 "high risk" patients. Considering a recent trend toward routine central lymphadenectomy avoiding radioactive treatment, prospective randomized trials are needed to evaluate the benefits of different approaches.
authors.affiliation: Department of Anaesthesiologic, Surgical and Emergency Sciences. Second University of Naples. Italy.
authors.forename: G
authors.initials: G
authors.lastname: Conzo
authors.forename: G
authors.initials: G
authors.lastname: Docimo
authors.forename: C
authors.initials: C
authors.lastname: Mauriello
authors.forename: C
authors.initials: C
authors.lastname: Gambardella
authors.forename: D
authors.initials: D
authors.lastname: Esposito
authors.forename: F
authors.initials: F
authors.lastname: Cavallo
authors.forename: E
authors.initials: E
authors.lastname: Tartaglia
authors.forename: S
authors.initials: S
authors.lastname: Napolitano
authors.forename: L
authors.initials: L
authors.lastname: Santini
mesh_terms: D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary; D006801:Humans; D008207:Lymphatic Metastasis; D037981:Neck Dissection; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*