title: Hepatoprotective effect of manganese chloride against CCl4-induced liver injury in rats.
abstract: The aim of the present study is to evaluate the protective effect of manganese chloride against carbon tetrachloride (CCl4)-induced liver injury in rats. Manganese chloride (0.001, 0.01, 0.05 and 0.1 g/kg bw) was administered intragastrically for 28 consecutive days to male CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD). Histopathological changes in the liver of different groups were also studied. Administration of CCl4 increased the serum ALT, AST, ALP and GGT but decreased SOD levels in rats. Treatment with manganese chloride significantly attenuated these changes to nearly normal levels. The animals treated with manganese chloride have shown decreased necrotic zones and hepatocellular degeneration when compared to the liver exposed to CCl4 intoxication alone. Thus, the histopathological studies also supported the protective effect of manganese chloride. Therefore, the results of this study suggest that manganese chloride exerts hepatoprotection via promoting antioxidative properties against CCl4-induced oxidative liver damage.
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran, eidi@srbiau.ac.ir.
authors.forename: Akram
authors.initials: A
authors.lastname: Eidi
authors.forename: Pejman
authors.initials: P
authors.lastname: Mortazavi
authors.forename: Khodabakhsh
authors.initials: K
authors.lastname: Behzadi
authors.forename: Ali Haeri
authors.initials: AH
authors.lastname: Rohani
authors.forename: Shahabeddin
authors.initials: S
authors.lastname: Safi
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D002712:Chlorides / Q000737:chemistry / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D008297:Male; D017895:Manganese Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D002251:Carbon Tetrachloride; C025340:manganese chloride