title: Hyperlipidemia, tissue factor, coagulation, and simvastatin.
abstract: Hyperlipidemia affects millions of people worldwide and is a major risk factor for cardiovascular disease. People with hyperlipidemia have elevated levels of serum cholesterol and an increased risk of thrombosis. Studies have suggested that oxidized lipoproteins, such as oxidized low-density lipoprotein (oxLDL), contribute to the development of a pro-thrombotic state. In this review, we discuss our recent studies demonstrating a role for hematopoietic cell-derived tissue factor (TF) expression in the activation of coagulation and increased thrombosis associated with hyperlipidemia. In addition, we investigated the effect of simvastatin on TF expression and coagulation. We found that simvastatin reduced leukocyte TF expression, TF⁺ microparticles, and coagulation. These results and earlier studies suggest that the anti-coagulant activity of statins is due, in part, to their ability to reduce monocyte TF expression in patients with cardiovascular disease.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Albert Phillip
authors.initials: AP
authors.lastname: Owens
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: James Robert
authors.initials: JR
authors.lastname: Byrnes
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: nmackman@med.unc.edu.
authors.forename: Nigel
authors.initials: N
authors.lastname: Mackman
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D019821:Simvastatin / Q000494:pharmacology*; D013925:Thromboplastin / Q000502:physiology*; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013925:Thromboplastin; D019821:Simvastatin
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