title: Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.
abstract: Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.
authors.affiliation: Institut für Anorganische Chemie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich (Switzerland) http://www.chem.uzh.ch; School of Chemistry, University of Birmingham, Edgbaston, Birmingham B152TT (UK).
authors.forename: Siriporn
authors.initials: S
authors.lastname: Phongtongpasuk
authors.forename: Susann
authors.initials: S
authors.lastname: Paulus
authors.forename: Joachim
authors.initials: J
authors.lastname: Schnabl
authors.forename: Roland K O
authors.initials: RK
authors.lastname: Sigel
authors.forename: Bernhard
authors.initials: B
authors.lastname: Spingler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hannon
authors.forename: Eva
authors.initials: E
authors.lastname: Freisinger
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D012313:RNA / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D012313:RNA
keywords: RNA recognition; antitumor agents; bioinorganic chemistry; helicates; three-way junctions