title: CD90 is a diagnostic marker to differentiate between malignant pleural mesothelioma and lung carcinoma with immunohistochemistry.
abstract: OBJECTIVE
  To pathologically distinguish mesothelioma from lung carcinoma, particularly adenocarcinoma.
  
  
  METHODS
  We conducted immunohistochemical analyses on clinical specimens, including 26 cases of mesothelioma, 28 cases of lung adenocarcinoma, and 33 cases of lung squamous cell carcinoma.
  
  
  RESULTS
  We found that CD90 expression was useful in making a differential diagnosis between epithelioid mesothelioma and lung adenocarcinoma, whereas sarcomatoid mesothelioma and lung carcinoma specimens, irrespective of the histologic types, were negative in general. The sensitivity and specificity of CD90 expression in epithelioid mesothelioma and lung adenocarcinoma were comparable to those of well-established markers used for the differential diagnosis.
  
  
  CONCLUSIONS
  These data collectively indicate that CD90 is a novel diagnostic marker that contributes to a diagnosis of epithelioid mesothelioma.
authors.affiliation: Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan; e-mail: mtagawa@chiba-cc.jp.
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kawamura
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Takeo
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kuan
authors.initials: K
authors.lastname: Chai
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Masato
authors.initials: M
authors.lastname: Shingyoji
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yusa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tagawa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D045744:Cell Line, Tumor; D022081:Cell Surface Extensions / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D008654:Mesothelioma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012680:Sensitivity and Specificity; D018800:Thy-1 Antigens / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018800:Thy-1 Antigens
keywords: CD90; Immunohistochemistry; Lung carcinoma; Mesothelioma