title: Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs.
abstract: In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.
authors.forename: B
authors.initials: B
authors.lastname: Song
authors.forename: B N
authors.initials: BN
authors.lastname: Wang
authors.forename: D N
authors.initials: DN
authors.lastname: Chen
authors.forename: Z G
authors.initials: ZG
authors.lastname: Luo
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods; D004285:Dogs; D004452:Echocardiography; D004553:Electric Conductivity; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D013610:Tachycardia / Q000150:complications*; D016276:Ventricular Function; D020257:Ventricular Remodeling / Q000502:physiology*
references.citation: J Mol Cell Cardiol. 2006 Jan;40(1):76-86
references.pmid: 16236311
references.citation: Cardiol J. 2011;18(5):573-6
references.pmid: 21947998
references.citation: Cardiovasc Res. 1995 Dec;30(6):848-56
references.pmid: 8746198
references.citation: J Electrocardiol. 1999 Jul;32(3):217-24
references.pmid: 10465565
references.citation: Heart Rhythm. 2006 Mar;3(3):345-52
references.pmid: 16500310
references.citation: J Am Coll Cardiol. 2000 Mar 1;35(3):569-82
references.pmid: 10716457
references.citation: Circulation. 1998 Sep 15;98(11):1125-35
references.pmid: 9736600
references.citation: Circulation. 2003 Jun 10;107(22):2844-9
references.pmid: 12756152
references.citation: Circulation. 1997 Feb 4;95(3):732-9
references.pmid: 9024164
references.citation: Cardiovasc Res. 1996 Feb;31(2):314-23
references.pmid: 8730409
references.citation: Aust N Z J Med. 1999 Jun;29(3):395-402
references.pmid: 10868511
references.citation: Physiol Rev. 1999 Jan;79(1):215-62
references.pmid: 9922372
references.citation: J Pharmacol Exp Ther. 1999 Nov;291(2):799-811
references.pmid: 10525103
references.citation: JACC Cardiovasc Imaging. 2011 Jan;4(1):98-108
references.pmid: 21232712
references.citation: Circulation. 1997 Nov 18;96(10):3696-703
references.pmid: 9396473
references.citation: Trends Cardiovasc Med. 2003 Nov;13(8):316-22
references.pmid: 14596946
references.citation: Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H62-9
references.pmid: 20435845
references.citation: Circulation. 2002 Jul 16;106(3):362-7
references.pmid: 12119254
references.citation: Circulation. 2001 Nov 20;104(21):2608-14
references.pmid: 11714658
references.citation: Am J Med. 2003 Jan;114(1):51-5
references.pmid: 12543289
references.citation: Basic Res Cardiol. 2004 Jul;99(4):288-98
references.pmid: 15221347
references.citation: Int J Cardiol. 2011 Nov 17;153(1):36-41
references.pmid: 20880599
references.citation: Am Heart Hosp J. 2010 Winter;8(2):E115-7
references.pmid: 21928177