title: Factors affecting bone strength other than osteoporosis.
abstract: Osteoporosis is the most common cause of bone fragility, especially in post-menopausal women. Bone strength may be compromised by several other medical conditions and medications, which must be ruled out in the clinical management of patients affected by fragility fractures. Indeed, 20-30% of women and up to 50% of men affected by bone fragility are diagnosed with other conditions affecting bone strength other than osteoporosis. These conditions include disorders of bone homeostasis, impaired bone remodeling, collagen disorders, and medications qualitatively and quantitatively affecting bone strength. Proper diagnosis allows correct treatment to prevent the occurrence of fragility fractures.
authors.affiliation: Dipartimento di Ortopedia e Traumatologia, Università Dell'Insubria, Viale Luigi Borri 57, 21100, Varese, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ratti
authors.forename: Ettore
authors.initials: E
authors.lastname: Vulcano
authors.forename: Gianluca
authors.initials: G
authors.lastname: Canton
authors.forename: Marco
authors.initials: M
authors.lastname: Marano
authors.forename: Luigi
authors.initials: L
authors.lastname: Murena
authors.forename: Paolo
authors.initials: P
authors.lastname: Cherubino
mesh_terms: D015519:Bone Density; D001847:Bone Diseases / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis*; D016723:Bone Remodeling; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D004700:Endocrine System Diseases / Q000150:complications; D005260:Female; D017102:Fracture Healing; D050723:Fractures, Bone / Q000175:diagnosis* / Q000209:etiology; D006706:Homeostasis; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis*; D017698:Postmenopause
chemical_list: D003094:Collagen