title: Cellular immune response in young children accounts for recurrent acute otitis media.
abstract: Acute otitis media (AOM) is a common disease in young children. Streptococcus pneumoniae (Spn) and Haemophilus influenzae (NTHi) are the two most common pathogens that cause AOM. Over the past 5 years, our group has been studying the immunologic profile of children that experience repeated AOM infections despite tympanocentesis drainage of middle ear fluid and individualized antibiotic treatment; we call these children stringently-defined otitis prone(sOP). Although protection against AOM is primarily mediated by ototpathogen-specific antibody, our recent studies suggest that suboptimal memory B and T cell responses and an immaturity in antigen-presenting cells may play a significant role in the propensity to recurrent AOM infections. This review focuses on the studies performed to define immunologic dysfunction in sOP children.
authors.forename: Sharad K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Michael E
authors.initials: ME
authors.lastname: Pichichero
mesh_terms: D000208:Acute Disease; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D010033:Otitis Media / Q000188:drug therapy / Q000276:immunology*; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology
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