title: An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children.
abstract: This study describes a population pharmacokinetic meta-analysis of propofol to characterize the influence of body size measures and age in morbidly obese and nonobese adults, adolescents, and children. Sixty morbidly obese and nonobese adult patients (55-167 kg; 21-79 years) and 34 morbidly obese and nonobese adolescents and children (37-184 kg; 9-20 years) were included. The results show that clearance increased with total body weight in an allometric function while age was found to influence clearance in a bilinear fashion with two distinct slopes, reflecting an initial increase and subsequent decrease as a result of aging. Using these two functions, the influence of both (over)weight and age on propofol clearance was well characterized, which may provide a basis for dosing across this diverse group of patients.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e73; doi:10.1038/psp.2013.47; advance online publication 11 September 2013.
authors.affiliation: Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Diepstraten
authors.forename: V
authors.initials: V
authors.lastname: Chidambaran
authors.forename: S
authors.initials: S
authors.lastname: Sadhasivam
authors.forename: H J
authors.initials: HJ
authors.lastname: Blussé van Oud-Alblas
authors.forename: T
authors.initials: T
authors.lastname: Inge
authors.forename: B
authors.initials: B
authors.lastname: van Ramshorst
authors.forename: E P A
authors.initials: EP
authors.lastname: van Dongen
authors.forename: A A
authors.initials: AA
authors.lastname: Vinks
authors.forename: C A J
authors.initials: CA
authors.lastname: Knibbe
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