title: Endocrine therapy for growth retardation in paediatric inflammatory bowel disease.
abstract: Inflammatory bowel disease, particularly Crohn's disease (CD), can potentially cause growth failure during childhood as well as a reduction in final adult height. The underlying mechanism is multifactorial and includes poor nutrition, chronic inflammation, and the prolonged use of steroids. Despite major advances in the treatment of CD, current cohorts of children continue to display a deficit in linear growth and may qualify for growth-promoting hormonal therapy. However, currently there is limited evidence to support the use of endocrine therapy directed primarily at improving growth. This review is aimed at summarising the current evidence for growth impairment in inflammatory bowel disease and discusses the rationale for using growth promoting therapy.
authors.affiliation: Developmental Endocrinology Research Group, Royal Hospital for Sick Children, University of Glasgow, Yorkhill, Glasgow, G3 8SJ, UK.
authors.forename: Mabrouka A
authors.initials: MA
authors.lastname: Altowati
authors.forename: Richard K
authors.initials: RK
authors.lastname: Russell
authors.forename: S Faisal
authors.initials: SF
authors.lastname: Ahmed
mesh_terms: D002648:Child; D003424:Crohn Disease / Q000150:complications*; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D009748:Nutrition Disorders / Q000209:etiology
chemical_list: D013006:Growth Hormone
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