title: Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.
abstract: Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.
authors.affiliation: Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA ; Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Espinoza
authors.forename: Radhika
authors.initials: R
authors.lastname: Pochampally
authors.forename: Fei
authors.initials: F
authors.lastname: Xing
authors.forename: Kounosuke
authors.initials: K
authors.lastname: Watabe
authors.forename: Lucio
authors.initials: L
authors.lastname: Miele
keywords: EMT; Notch inhibitors; Notch signaling; cancer stem cells; mesenchymal stem cells; metastases
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