title: Intravenous tenecteplase in acute ischemic stroke: an updated review.
abstract: Tenecteplase in a genetically engineered variant of alteplase. Although the two have the same mechanism of action, tenecteplase has properties that makes it a seemingly more advantageous thrombolytic. Because of its rapid single-bolus administration, its use is favored over alteplase in the treatment of acute myocardial infarction. Over the past few years, several clinical studies have been conducted to assess the safety, feasibility, and efficacy of tenecteplase in ischemic stroke. In spite of the mixed results of these studies, experimentation with tenecteplase continues in from of clinical trials. In this article, the utility of tenecteplase in ischemic stroke will be discussed.
authors.affiliation: Division of Cerebrovascular Diseases and Neurological Critical Care, Department of Neurology, The Ohio State University College of Medicine, 395 West 12th Avenue, Suite 766, Columbus, OH, 43215, USA, reza.behrouz@osumc.edu.
authors.forename: Réza
authors.initials: R
authors.lastname: Behrouz
mesh_terms: D061605:Administration, Intravenous; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007511:Ischemia / Q000150:complications; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D000077785:Tenecteplase; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase
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