title: Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes.
authors.affiliation: Chemistry of Life Processes Institute and Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA) http://www.chemistry.northwestern.edu/faculty/thomas-ohalloran.html.
authors.forename: Đenana U
authors.initials: ĐU
authors.lastname: Miodragović
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Quentzel
authors.forename: Josh W
authors.initials: JW
authors.lastname: Kurutz
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Stern
authors.forename: Richard W
authors.initials: RW
authors.lastname: Ahn
authors.forename: Irawati
authors.initials: I
authors.lastname: Kandela
authors.forename: Andrew
authors.initials: A
authors.lastname: Mazar
authors.forename: Thomas V
authors.initials: TV
authors.lastname: O'Halloran
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D018053:Arsenites / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology*; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D018053:Arsenites; D009944:Organoplatinum Compounds; D014867:Water; D010984:Platinum; C032793:arsenous acid
keywords: X-ray diffraction; antitumor agents; arsenic; drug design; platinum
references.citation: Oncogene. 2003 Oct 20;22(47):7265-79
references.pmid: 14576837
references.citation: Nat Rev Drug Discov. 2010 Jun;9(6):447-64
references.pmid: 20467424
references.citation: Inorg Chem. 2006 Dec 25;45(26):10567-75
references.pmid: 17173411
references.citation: Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12258-62
references.pmid: 23124954
references.citation: Inorg Chem. 2001 Sep 10;40(19):4816-7
references.pmid: 11531424
references.citation: Met Based Drugs. 2008;2008:260146
references.pmid: 18431449
references.citation: Adv Drug Deliv Rev. 2012 Aug;64(11):993-1004
references.pmid: 22289471
references.citation: Angew Chem Int Ed Engl. 2009;48(49):9295-9
references.pmid: 19894238
references.citation: Nat Rev Cancer. 2007 Aug;7(8):573-84
references.pmid: 17625587
references.citation: Chem Soc Rev. 2007 Apr;36(4):665-86
references.pmid: 17387413
references.citation: Cancer Biol Ther. 2006 Aug;5(8):943-9
references.pmid: 16775422
references.citation: Expert Opin Pharmacother. 2008 Jul;9(10):1773-85
references.pmid: 18570609
references.citation: Dalton Trans. 2010 Sep 21;39(35):8113-27
references.pmid: 20593091
references.citation: Inorg Chem. 2002 Jan 28;41(2):170-9
references.pmid: 11800605
references.citation: Blood Rev. 2010 Jul-Sep;24(4-5):191-9
references.pmid: 20471733
references.citation: Science. 2010 Apr 9;328(5975):240-3
references.pmid: 20378816
references.citation: Nat Rev Drug Discov. 2005 Apr;4(4):307-20
references.pmid: 15789122
references.citation: J Exp Clin Cancer Res. 2009 Aug 08;28:110
references.pmid: 19664237
references.citation: Nature. 1969 Apr 26;222(5191):385-6
references.pmid: 5782119
references.citation: J Biol Chem. 2009 Jul 10;284(28):18583-7
references.pmid: 19363033
references.citation: Cancer Sci. 2009 Dec;100(12):2459-64
references.pmid: 19769630
references.citation: Dalton Trans. 2006 Feb 28;(8):1020-3
references.pmid: 16474887