title: Hypertension in pregnancy is a risk factor for microalbuminuria later in life.
abstract: The authors aimed to compare renal function by estimated glomerular filtration rate and albuminuria in 3 groups of women: nulliparous women, women with a history of normotensive pregnancies, and women with a history of at least one hypertensive pregnancy. Women who participated in the second Family Blood Pressure Program Study visit (2000-2004) and had serum creatinine and urine albumin measurements (n=3015) were categorized as having had no pregnancy lasting >6 months (n=341), having had only normotensive pregnancies (n=2199), or having had at least 1 pregnancy with hypertension (n=475) based on a standardized questionnaire. Women who reported having had at least one pregnancy with hypertension were significantly more likely to be hypertensive (75.6% vs 59.4%, P<.001), diabetic (34.2% vs 27.3%, P≤.001), and have higher body mass index (32.8 vs 30.5, P<.001) than those who reported normotensive pregnancies. There was a significantly greater risk of microalbuminuria (urine albumin-creatinine ratio >25 mg/g) in those who reported at least one pregnancy with hypertension (odds ratio, 1.37; confidence interval, 1.02-1.85; P=.04) than in those with normotensive pregnancies, after adjusting for risk factors for chronic kidney and cardiovascular disease. Hypertension in pregnancy is associated with an increased risk of future microalbuminuria.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
authors.forename: Andrea G
authors.initials: AG
authors.lastname: Kattah
authors.forename: Reem
authors.initials: R
authors.lastname: Asad
authors.forename: Dawn C
authors.initials: DC
authors.lastname: Scantlebury
authors.forename: Kent R
authors.initials: KR
authors.lastname: Bailey
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Wiste
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
authors.forename: Sharon L R
authors.initials: SL
authors.lastname: Kardia
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Turner
authors.forename: Vesna D
authors.initials: VD
authors.lastname: Garovic
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000419:Albuminuria / Q000453:epidemiology*; D015992:Body Mass Index; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology*; D015994:Incidence; D007668:Kidney / Q000503:physiopathology; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D003404:Creatinine
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