title: Collagen-like peptides and peptide-polymer conjugates in the design of assembled materials.
abstract: Collagen is the most abundant protein in mammals, and there has been long-standing interest in understanding and controlling collagen assembly in the design of new materials. Collagen-like peptides (CLP), also known as collagen-mimetic peptides (CMP) or collagen-related peptides (CRP), have thus been widely used to elucidate collagen triple helix structure as well as to produce higher-order structures that mimic natural collagen fibers. This mini-review provides an overview of recent progress on these topics, in three broad topical areas. The first focuses on reported developments in deciphering the chemical basis for collagen triple helix stabilization, which we review not with the intent of describing the basic structure and biological function of collagen, but to summarize different pathways for designing collagen-like peptides with high thermostability. Various approaches for producing higher-order structures via CLP self-assembly, via various types of intermolecular interaction, are then discussed. Finally, recent developments in a new area, the production of polymer-CLP bioconjugates, are summarized. Biological applications of collagen contained hydrogels are also included in this section. The topics may serve as a guide for the design of collagen-like peptides and their bioconjugates for targeted application in the biomedical arena.
authors.affiliation: Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716.
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Luo
authors.forename: Kristi L
authors.initials: KL
authors.lastname: Kiick
keywords: Collagen like peptide; bioconjugate; hydrogel; self-assembly; triple helix
references.citation: Biomaterials. 2008 Oct;29(29):3960-72
references.pmid: 18639928
references.citation: J Cell Sci. 2007 Jun 15;120(Pt 12):1955-8
references.pmid: 17550969
references.citation: Biomacromolecules. 2009 Sep 14;10(9):2626-31
references.pmid: 19681603
references.citation: J Am Chem Soc. 2002 Nov 27;124(47):14085-91
references.pmid: 12440907
references.citation: Nucl Med Biol. 2006 Jan;33(1):43-52
references.pmid: 16459258
references.citation: Org Lett. 2001 Jan 11;3(1):9-12
references.pmid: 11429880
references.citation: Biopolymers. 2008 May;89(5):443-54
references.pmid: 17937398
references.citation: Biochemistry. 2000 Dec 5;39(48):14960-7
references.pmid: 11101312
references.citation: J Mol Biol. 2001 May 18;308(5):1081-9
references.pmid: 11352592
references.citation: Biomaterials. 2010 Mar;31(8):2141-52
references.pmid: 19962751
references.citation: Biomacromolecules. 2011 Feb 14;12(2):269-89
references.pmid: 21235251
references.citation: J Org Chem. 2002 May 3;67(9):3057-64
references.pmid: 11975567
references.citation: Biomacromolecules. 2009 Oct 12;10(10):2740-9
references.pmid: 19743840
references.citation: J Biol Chem. 2000 May 12;275(19):14532-6
references.pmid: 10799537
references.citation: Biomaterials. 2012 Jun;33(19):4801-9
references.pmid: 22463934
references.citation: J Am Chem Soc. 2002 Mar 20;124(11):2497-505
references.pmid: 11890798
references.citation: J Mol Biol. 2000 Sep 1;301(5):1191-205
references.pmid: 10966815
references.citation: Biochim Biophys Acta. 1976 Jan 20;420(1):133-41
references.pmid: 1247577
references.citation: Biomacromolecules. 2008 Aug;9(8):2111-7
references.pmid: 18627200
references.citation: Macromol Biosci. 2010 Aug 11;10(8):836-41
references.pmid: 20486141
references.citation: Biochim Biophys Acta. 1973 Sep 21;322(1):166-71
references.pmid: 4744330
references.citation: Nature. 1955 Sep 24;176(4482):593-5
references.pmid: 13265783
references.citation: J Am Chem Soc. 2005 Mar 30;127(12):4130-1
references.pmid: 15783169
references.citation: Biomaterials. 2006 Oct;27(30):5268-76
references.pmid: 16797067
references.citation: J Am Chem Soc. 1996;118(49):12261-12266
references.pmid: 21451735
references.citation: J Biol Chem. 1997 Nov 14;272(46):28837-40
references.pmid: 9360948
references.citation: Arch Virol. 1999;144(1):177-84
references.pmid: 10076518
references.citation: Chem Soc Rev. 2010 Sep;39(9):3510-27
references.pmid: 20676409
references.citation: J Biol Chem. 2012 Mar 9;287(11):8039-47
references.pmid: 22179819
references.citation: Biomacromolecules. 2011 Jul 11;12(7):2610-6
references.pmid: 21615178
references.citation: J Am Chem Soc. 2007 Nov 28;129(47):14780-7
references.pmid: 17985903
references.citation: Macromol Biosci. 2007 Jan 5;7(1):56-69
references.pmid: 17238231
references.citation: Biopolymers. 1998;47(2):143-51
references.pmid: 9703769
references.citation: ACS Nano. 2011 Oct 25;5(10):7739-47
references.pmid: 21899363
references.citation: Biomaterials. 2012 Sep;33(26):6140-6
references.pmid: 22698726
references.citation: Chemistry. 2003 Aug 4;9(15):3703-14
references.pmid: 12898697
references.citation: Biomacromolecules. 2008 Oct;9(10):2929-36
references.pmid: 18816098
references.citation: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14767-72
references.pmid: 22927373
references.citation: Biochemistry. 2009 Aug 25;48(33):7959-68
references.pmid: 19610672
references.citation: Annu Rev Biochem. 2009;78:929-58
references.pmid: 19344236
references.citation: Nat Mater. 2008 Mar;7(3):248-54
references.pmid: 18246072
references.citation: Adv Drug Deliv Rev. 2002 Jun 17;54(4):459-76
references.pmid: 12052709
references.citation: J Am Chem Soc. 2001 Jan 31;123(4):777-8
references.pmid: 11456609
references.citation: Soft Matter. 2012 Jan 1;8:10409-10418
references.pmid: 23908674
references.citation: Soft Matter. 2012 Apr 14;8(14):3832-3840
references.pmid: 23762176
references.citation: Burns. 2007 May;33(3):364-8
references.pmid: 17240532
references.citation: Chem Biol. 1999 Feb;6(2):63-70
references.pmid: 10021421
references.citation: Langmuir. 2012 Feb 14;28(6):3194-9
references.pmid: 22243030
references.citation: J Biol Chem. 2005 May 13;280(19):19343-9
references.pmid: 15753081
references.citation: J Biol Chem. 2005 Apr 8;280(14):13848-57
references.pmid: 15647274
references.citation: Adv Drug Deliv Rev. 2002 Jun 17;54(4):477-85
references.pmid: 12052710
references.citation: J Biol Chem. 2006 Nov 3;281(44):33283-90
references.pmid: 16963782
references.citation: Clin Oral Implants Res. 2006 Aug;17(4):359-66
references.pmid: 16907765
references.citation: Soft Matter. 2011 Oct 20;20(7):9758-9766
references.pmid: 24039625
references.citation: J Mol Biol. 2004 Jan 30;335(5):1289-97
references.pmid: 14729344
references.citation: J Am Chem Soc. 2011 Sep 21;133(37):14469-71
references.pmid: 21863857
references.citation: Angew Chem Int Ed Engl. 2002 Jul 15;41(14):2596-9
references.pmid: 12203546
references.citation: Biomacromolecules. 2012 Sep 10;13(9):2645-54
references.pmid: 22849577
references.citation: Biopolymers. 2010;94(1):32-48
references.pmid: 20091878
references.citation: Biochem J. 1996 May 15;316 ( Pt 1):1-11
references.pmid: 8645190
references.citation: J Mol Biol. 2002 Feb 15;316(2):385-94
references.pmid: 11851346
references.citation: Biochemistry. 2011 Apr 5;50(13):2381-3
references.pmid: 21375275
references.citation: Mater Sci Eng R Rep. 2008 Jan;62(4):125-155
references.pmid: 19122836
references.citation: Biochemistry. 2005 Feb 8;44(5):1414-22
references.pmid: 15683226
references.citation: Macromol Biosci. 2011 Feb 11;11(2):192-8
references.pmid: 20976724
references.citation: J Am Chem Soc. 2008 Sep 24;130(38):12610-1
references.pmid: 18763780
references.citation: Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8513-8
references.pmid: 18559857
references.citation: Langmuir. 2012 Jan 31;28(4):1993-7
references.pmid: 22165843
references.citation: Nat Rev Drug Discov. 2003 Mar;2(3):214-21
references.pmid: 12612647
references.citation: J Struct Biol. 1998;122(1-2):86-91
references.pmid: 9724608
references.citation: Macromolecules. 2009 Apr;42(7):2532-2541
references.pmid: 19763157
references.citation: Bioconjug Chem. 2011 Oct 19;22(10):1946-53
references.pmid: 21863904
references.citation: Biochemistry. 1974 Aug 13;13(17):3459-64
references.pmid: 4602296
references.citation: J Mol Biol. 1991 Mar 5;218(1):209-19
references.pmid: 2002504
references.citation: Angew Chem Int Ed Engl. 2006 Oct 27;45(42):7015-8
references.pmid: 17009283
references.citation: Biomaterials. 2010 Nov;31(31):7873-82
references.pmid: 20674012
references.citation: Biomacromolecules. 2010 Sep 13;11(9):2336-44
references.pmid: 20715762
references.citation: Biomacromolecules. 2012 May 14;13(5):1625-31
references.pmid: 22559049
references.citation: Angew Chem Int Ed Engl. 2006 Mar 27;45(14):2267-70
references.pmid: 16511895
references.citation: Biomacromolecules. 2012 Jun 11;13(6):1774-86
references.pmid: 22533503
references.citation: Tissue Eng Part A. 2008 Nov;14(11):1843-51
references.pmid: 18826339
references.citation: Biomaterials. 2011 Sep;32(27):6412-24
references.pmid: 21658756
references.citation: Biomacromolecules. 2003 Jul-Aug;4(4):859-63
references.pmid: 12857065
references.citation: Nature. 1998 Apr 16;392(6677):666-7
references.pmid: 9565027
references.citation: Chem Commun (Camb). 2005 Sep 7;(33):4172-4
references.pmid: 16100593
references.citation: Eur J Biochem. 1980 May;106(2):619-32
references.pmid: 7398630
references.citation: Acta Biomater. 2009 Sep;5(7):2591-600
references.pmid: 19427824
references.citation: Macromol Biosci. 2012 Dec;12(12):1660-70
references.pmid: 23070928
references.citation: Biomacromolecules. 2011 Jun 13;12(6):2184-92
references.pmid: 21553871
references.citation: J Am Chem Soc. 2007 Feb 28;129(8):2202-3
references.pmid: 17269769
references.citation: Nat Chem. 2011 Aug 28;3(10):821-8
references.pmid: 21941256