title: A tale of two gases: NO and H2S, foes or friends for life?
abstract: Nitric oxide (NO) and hydrogen sulfide (H2S) have emerged as dominant redox regulators of numerous aspects of cellular and physiological functions within several organ systems included cardiovascular, immune and neurological tissues. Recent studies have begun to reveal that these two gaseous molecules may have redundant or overlapping pathophysiological functions often involving similar molecular targets. However, it remains less clear when and how NO and H2S may interact under biological and disease processes. In this graphical review, we discuss the current understanding of NO and H2S interactions and how they may functionally influence each other and what this may mean for biology and mechanisms of disease.
authors.affiliation: Department of Pathology, LSU Health-Shreveport, USA.
authors.forename: Gopi K
authors.initials: GK
authors.lastname: Kolluru
authors.forename: Xinggui
authors.initials: X
authors.lastname: Shen
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Kevil
mesh_terms: D006862:Hydrogen Sulfide / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide; D006862:Hydrogen Sulfide
keywords: Cardiovascular disease; Chemistry; Redox biology; Thiol; Vascular biology
references.citation: Nat Rev Drug Discov. 2008 Feb;7(2):156-67
references.pmid: 18167491
references.citation: Nitric Oxide. 2008 Sep;19(2):68-72
references.pmid: 18503780
references.citation: J Vasc Res. 2008;45(6):521-8
references.pmid: 18463417
references.citation: Circ Res. 2003 Jul 25;93(2):96-105
references.pmid: 12881475
references.citation: Br J Pharmacol. 2011 Oct;164(3):853-65
references.pmid: 21198548
references.citation: Science. 2008 Oct 24;322(5901):587-90
references.pmid: 18948540
references.citation: Biochem J. 1998 May 15;332 ( Pt 1):9-19
references.pmid: 9576846
references.citation: Mol Cell. 2012 Jan 13;45(1):13-24
references.pmid: 22244329
references.citation: Br J Pharmacol. 2006 Nov;149(6):625-34
references.pmid: 17016507
references.citation: Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):444-8
references.pmid: 1346070
references.citation: Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9161-6
references.pmid: 22570497
references.citation: PLoS One. 2012;7(4):e34892
references.pmid: 22506056
references.citation: Cardiovasc Res. 2010 Dec 1;88(3):482-91
references.pmid: 20660605
references.citation: Eur J Pharm Sci. 2013 Jan 23;48(1-2):211-5
references.pmid: 23148920
references.citation: Biochem Biophys Res Commun. 2006 Apr 28;343(1):303-10
references.pmid: 16540095
references.citation: J Biol Chem. 2008 Dec 12;283(50):35265-72
references.pmid: 18840608
references.citation: Sci Signal. 2009 Nov 10;2(96):ra72
references.pmid: 19903941
references.citation: Sci Signal. 2011 Dec 13;4(203):ra86
references.pmid: 22169477
references.citation: Am J Physiol. 1999 Apr;276(4):C803-11
references.pmid: 10199810
references.citation: Life Sci. 2007 Apr 10;80(18):1664-8
references.pmid: 17350050
references.citation: Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1998-2004
references.pmid: 20634473
references.citation: Mol Nutr Food Res. 2010 May;54 Suppl 1:S42-52
references.pmid: 20229525
references.citation: Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14492-7
references.pmid: 8962079
references.citation: J Biol Chem. 2002 Nov 8;277(45):42680-5
references.pmid: 12213817
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R243-52
references.pmid: 15345473
references.citation: Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1330-H1340
references.pmid: 18660450
references.citation: Pharmacol Ther. 2007 Feb;113(2):442-58
references.pmid: 17222913
references.citation: Arch Biochem Biophys. 1995 Apr 20;318(2):279-85
references.pmid: 7733655
references.citation: Circ Res. 2009 Aug 14;105(4):365-74
references.pmid: 19608979
references.citation: Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H868-76
references.pmid: 19168723
references.citation: Free Radic Biol Med. 2013 Feb;55:1-7
references.pmid: 23165065
references.citation: Free Radic Biol Med. 2006 Jul 1;41(1):106-19
references.pmid: 16781459
references.citation: Free Radic Biol Med. 2008 Sep 1;45(5):578-84
references.pmid: 18503778
references.citation: Physiol Rev. 2012 Apr;92(2):791-896
references.pmid: 22535897
references.citation: J Pharmacol Exp Ther. 2008 Feb;324(2):876-82
references.pmid: 18029544
references.citation: Mol Cell Biochem. 2012 Jan;360(1-2):61-9
references.pmid: 21879311
references.citation: Chin Med J (Engl). 2008 Mar 5;121(5):420-3
references.pmid: 18364114
references.citation: J Neurochem. 2004 Aug;90(3):765-8
references.pmid: 15255956
references.citation: Acta Pharmacol Sin. 2006 Aug;27(8):971-80
references.pmid: 16867247
references.citation: Mol Cell Biochem. 2013 Mar;375(1-2):199-206
references.pmid: 23242603
references.citation: Nat Rev Mol Cell Biol. 2012 Jul 11;13(8):499-507
references.pmid: 22781905
references.citation: Circulation. 2013 Mar 12;127(10):1116-27
references.pmid: 23393010
references.citation: Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1215-24
references.pmid: 23479260
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1608-18
references.pmid: 17634203
references.citation: Free Radic Biol Med. 2005 Dec 1;39(11):1478-88
references.pmid: 16274883
references.citation: Antioxid Redox Signal. 2010 May 1;12(9):1065-77
references.pmid: 19842913
references.citation: J Am Chem Soc. 2012 Jul 25;134(29):12016-27
references.pmid: 22741609
references.citation: Toxicology. 2007 Nov 20;241(1-2):92-7
references.pmid: 17888559
references.citation: Biochem J. 2012 Jan 15;441(2):609-21
references.pmid: 21950347
references.citation: Pharmacol Rev. 1991 Jun;43(2):109-42
references.pmid: 1852778
references.citation: Biochimie. 2010 Sep;92(9):1186-98
references.pmid: 20363286
references.citation: J Med Chem. 2013 Feb 28;56(4):1499-508
references.pmid: 23418783
references.citation: Trends Pharmacol Sci. 2008 Dec;29(12):601-8
references.pmid: 18835046
references.citation: Clin Exp Pharmacol Physiol. 2000 Apr;27(4):313-9
references.pmid: 10779131
references.citation: Sci Signal. 2012 Mar 13;5(215):pe10
references.pmid: 22416275
references.citation: Cardiovasc Res. 2007 Oct 1;76(1):29-40
references.pmid: 17631873
references.citation: Chemistry. 2012 Oct 15;18(42):13538-40
references.pmid: 22996412
references.citation: Am J Physiol Renal Physiol. 2008 Oct;295(4):F912-22
references.pmid: 18701635
references.citation: Annu Rev Pharmacol Toxicol. 2011;51:169-87
references.pmid: 21210746
references.citation: Biochem Biophys Res Commun. 1997 Aug 28;237(3):527-31
references.pmid: 9299397
references.citation: J Am Heart Assoc. 2012 Oct;1(5):e004093
references.pmid: 23316304
references.citation: Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2410-8
references.pmid: 22467307
references.citation: Nature. 1995 Sep 21;377(6546):239-42
references.pmid: 7545787