title: Evaluation of systemic oxidant/antioxidant status and paraoxonase 1 enzyme activities in psoriatic patients treated by narrow band ultraviolet B phototherapy.
abstract: OBJECTIVE
  Ultraviolet B is a potent oxidative stress (OS) inducer in the skin; however, there are no data about the systemic oxidative effect of narrow band ultraviolet B (NB-UVB) phototherapy. In this study, we aimed to investigate the change in the OS status of psoriatic patients who were treated by NB-UVB phototherapy and to determine the relationships between OS, psoriasis severity, and systemic inflammatory condition.
  
  
  METHODS
  Twenty-four psoriatic patients were treated with a total of 30 sessions of NB-UVB irradiation. Psoriasis area and severity index (PASI), serum levels of high sensitive C-reactive protein (hsCRP), total antioxidant status (TAS), total oxidant status (TOS), the oxidative stress index (OSI), serum paraoxonase (PON), and arylesterase (ARE) activities before and after NB-UVB therapy were determined.
  
  
  RESULTS
  PASI scores significantly decreased after NB-UVB therapy (P = 0.001). The pre- and post-treatment hsCRP and TAS levels were similar (P = 0.253 and 0.301, respectively). TOS and OSI values significantly increased after phototherapy (both P < 0.001). PON and ARE activities did not change after treatment (both P > 0.05). There was no correlation between PASI and hsCRP, TAS, TOS, OSI, PON, and ARE values (P > 0.05).
  
  
  CONCLUSIONS
  A systemic OS may emerge in psoriatic patients treated by NB-UVB phototherapy.
authors.affiliation: Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: S D
authors.initials: SD
authors.lastname: Pektas
authors.forename: G
authors.initials: G
authors.lastname: Akoglu
authors.forename: A
authors.initials: A
authors.lastname: Metin
authors.forename: S
authors.initials: S
authors.lastname: Neselioglu
authors.forename: O
authors.initials: O
authors.lastname: Erel
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D011446:Prospective Studies; D011565:Psoriasis / Q000378:metabolism* / Q000628:therapy*; D014467:Ultraviolet Therapy / Q000379:methods*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D043303:Aryldialkylphosphatase
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