title: Peripheral insertion of umbilical cord.
abstract: Numerous studies have addressed the significance of marginal and membranous umbilical cord (UC) insertion. Recent reports suggest that an eccentrically inserted UC may also be important. This case-control study assessed the potential relevance of peripheral insertion of UC (PIUC), defined as <3 cm from the nearest margin. Singleton placentas (n  =  1418) submitted to the pathology department over an 18-month period were analyzed. Each case of PIUC (n  =  119) was matched with a control placenta of the same gestational age. Placentas with marginal or membranous UC and multiple gestations were excluded. The overall prevalence of PIUC was 8.4%, but PIUC frequency was significantly increased in premature births at <28 weeks (21.4%, P < 0.001). There was no association with other adverse pregnancy outcomes. PIUC was associated with decreased placental weight Z-score (-0.69 ± 0.92 versus -0.22 ± 1.3, P  =  0.0056), but not fetal weight Z-score, suggesting increased utilization of placental reserve. PIUC was also associated with relatively elongated placentas (length minus width: 2.6 ± 3.2 versus 1.0 ± 3.1, P  =  0.006). PIUC tended to be more frequent in young primiparous mothers and was significantly less common in women with a history of prior curettage (66% vs 50%, P  =  0.013). These data, together with equivalent rates of prior cesarean section, multiparity, and advanced maternal age, support a primary developmental disorder as opposed to secondary placental migration due to underlying uterine abnormalities ("trophotropism"). Except for a borderline significant association with findings suggestive of maternal malperfusion (P  =  0.078), PIUC was not associated with other placental lesions.
authors.affiliation: 1  Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Guangju
authors.initials: G
authors.lastname: Luo
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Redline
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010920:Placenta / Q000002:abnormalities*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D014470:Umbilical Cord / Q000002:abnormalities*