title: Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.
abstract: The Ras-MAPK signaling pathway is highly conserved throughout evolution and is activated downstream of a wide range of receptor stimuli. Ras guanine nucleotide exchange factors (RasGEFs) catalyze GTP loading of Ras and play a pivotal role in regulating receptor-ligand induced Ras activity. In T cells, three families of functionally important RasGEFs are expressed: RasGRF, RasGRP, and Son of Sevenless (SOS)-family GEFs. Early on it was recognized that Ras activation is critical for T cell development and that the RasGEFs play an important role herein. More recent work has revealed that nuances in Ras activation appear to significantly impact T cell development and selection. These nuances include distinct biochemical patterns of analog versus digital Ras activation, differences in cellular localization of Ras activation, and intricate interplays between the RasGEFs during distinct T cell developmental stages as revealed by various new mouse models. In many instances, the exact nature of these nuances in Ras activation or how these may result from fine-tuning of the RasGEFs is not understood. One large group of biomolecules critically involved in the control of RasGEFs functions are lipid second messengers. Multiple, yet distinct lipid products are generated following T cell receptor (TCR) stimulation and bind to different domains in the RasGRP and SOS RasGEFs to facilitate the activation of the membrane-anchored Ras GTPases. In this review we highlight how different lipid-based elements are generated by various enzymes downstream of the TCR and other receptors and how these dynamic and interrelated lipid products may fine-tune Ras activation by RasGEFs in developing T cells.
authors.affiliation: Department of Anatomy, University of California San Francisco , San Francisco, CA , USA.
authors.forename: Jesse E
authors.initials: JE
authors.lastname: Jun
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rubio
authors.forename: Jeroen P
authors.initials: JP
authors.lastname: Roose
keywords: LAT; P38; Ras; RasGRP; SOS; T cell; lipids; signaling
references.citation: J Immunol. 1994 Sep 15;153(6):2457-69
references.pmid: 8077660
references.citation: EMBO Rep. 2006 Jan;7(1):46-51
references.pmid: 16282985
references.citation: Biochim Biophys Acta. 2007 Aug;1773(8):1177-95
references.pmid: 17428555
references.citation: J Cell Biol. 1998 Feb 9;140(3):485-98
references.pmid: 9456311
references.citation: EMBO J. 1993 Jun;12(6):2265-73
references.pmid: 8389691
references.citation: Cell. 1999 Nov 24;99(5):521-32
references.pmid: 10589680
references.citation: Biochem Biophys Res Commun. 2009 Dec 25;390(4):1395-401
references.pmid: 19896467
references.citation: Science. 2001 Nov 9;294(5545):1299-304
references.pmid: 11701921
references.citation: Nat Genet. 2002 Sep;32(1):153-9
references.pmid: 12185366
references.citation: Proc Natl Acad Sci U S A. 2007 May 22;104(21):8953-8
references.pmid: 17517660
references.citation: Nat Immunol. 2009 Jun;10(6):627-35
references.pmid: 19430478
references.citation: Biochim Biophys Acta. 2011 Apr;1815(2):170-88
references.pmid: 21111786
references.citation: J Cell Biol. 2009 Mar 23;184(6):863-79
references.pmid: 19289794
references.citation: Annu Rev Immunol. 2006;24:771-800
references.pmid: 16551266
references.citation: PLoS One. 2008 Mar 05;3(3):e1718
references.pmid: 18320039
references.citation: Brain Res Mol Brain Res. 1997 Aug;48(1):140-4
references.pmid: 9379834
references.citation: PLoS One. 2011;6(9):e25540
references.pmid: 21966541
references.citation: Cancer Res. 2007 Nov 1;67(21):10190-7
references.pmid: 17974959
references.citation: PLoS Genet. 2011 Aug;7(8):e1002216
references.pmid: 21829393
references.citation: Immunol Rev. 2009 Mar;228(1):58-73
references.pmid: 19290921
references.citation: Nat Rev Mol Cell Biol. 2008 Feb;9(2):99-111
references.pmid: 18216767
references.citation: Exp Cell Res. 1985 Aug;159(2):441-50
references.pmid: 3896830
references.citation: Science. 2005 Mar 18;307(5716):1746-52
references.pmid: 15705808
references.citation: Oncogene. 2011 Nov 10;30(45):4590-4600
references.pmid: 21602881
references.citation: J Exp Med. 2010 Feb 15;207(2):309-18
references.pmid: 20123962
references.citation: Nature. 2006 Dec 7;444(7120):724-9
references.pmid: 17086201
references.citation: J Immunol. 2007 Oct 1;179(7):4890-900
references.pmid: 17878389
references.citation: Front Biol (Beijing). 2013 Oct 1;8(5):508-532
references.pmid: 24744772
references.citation: Biochem Soc Trans. 2005 Aug;33(Pt 4):662-3
references.pmid: 16042568
references.citation: Mol Cell Biol. 2004 Apr;24(8):3485-96
references.pmid: 15060167
references.citation: Nature. 1990 Aug 23;346(6286):719-23
references.pmid: 2201921
references.citation: Cell. 1993 May 7;73(3):611-20
references.pmid: 8490966
references.citation: Nat Immunol. 2006 Nov;7(11):1166-73
references.pmid: 17028589
references.citation: Methods Enzymol. 2006;407:128-43
references.pmid: 16757320
references.citation: Biochem J. 2006 Sep 1;398(2):243-56
references.pmid: 16709153
references.citation: J Biol Chem. 1994 Mar 25;269(12):9019-23
references.pmid: 7510700
references.citation: J Immunol. 2011 Dec 1;187(11):5941-51
references.pmid: 22048771
references.citation: Nat Immunol. 2001 Jan;2(1):29-36
references.pmid: 11135575
references.citation: J Mol Biol. 1997 Jun 20;269(4):579-91
references.pmid: 9217262
references.citation: EMBO J. 1997 Mar 17;16(6):1351-9
references.pmid: 9135150
references.citation: Nat Rev Cancer. 2010 Dec;10(12):842-57
references.pmid: 21102635
references.citation: Immunity. 2005 Oct;23(4):431-43
references.pmid: 16226508
references.citation: J Biol Chem. 1997 Jan 17;272(3):1799-804
references.pmid: 8999863
references.citation: Cell. 2010 Apr 30;141(3):458-71
references.pmid: 20416930
references.citation: Trends Biochem Sci. 2007 Jan;32(1):27-36
references.pmid: 17157506
references.citation: Nat Genet. 2007 Jan;39(1):75-9
references.pmid: 17143282
references.citation: Cell. 2004 Oct 29;119(3):393-405
references.pmid: 15507210
references.citation: Nat Cell Biol. 2007 Aug;9(8):905-14
references.pmid: 17618274
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11909-14
references.pmid: 18689679
references.citation: J Biol Chem. 2011 Apr 8;286(14):12712-23
references.pmid: 21285350
references.citation: Mol Cell Biol. 2004 Mar;24(6):2455-66
references.pmid: 14993283
references.citation: J Mol Biol. 2006 Jun 9;359(3):509-25
references.pmid: 16678204
references.citation: Nat Rev Immunol. 2006 Jul;6(7):532-40
references.pmid: 16799472
references.citation: Mol Pharmacol. 2004 Jul;66(1):76-84
references.pmid: 15213298
references.citation: Biochemistry. 2000 Jul 25;39(29):8674-82
references.pmid: 10913276
references.citation: J Virol. 1982 Jul;43(1):294-304
references.pmid: 6287003
references.citation: Small GTPases. 2011 Sep;2(5):282-288
references.pmid: 22292132
references.citation: J Cell Biol. 2001 Mar 19;152(6):1135-43
references.pmid: 11257115
references.citation: Immunity. 1998 Oct;9(4):565-74
references.pmid: 9806642
references.citation: PLoS One. 2012;7(6):e38796
references.pmid: 22719950
references.citation: Mol Cell Biol. 1992 Jul;12(7):3305-12
references.pmid: 1620132
references.citation: J Clin Invest. 2010 Dec;120(12):4353-65
references.pmid: 21041952
references.citation: Leukemia. 2012 May;26(5):1038-45
references.pmid: 22116551
references.citation: Biochem Soc Trans. 1997 May;25(2):561-5
references.pmid: 9191156
references.citation: Mol Cell Biol. 1998 Feb;18(2):880-6
references.pmid: 9447984
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4826-31
references.pmid: 10220378
references.citation: J Biol Chem. 1993 Aug 15;268(23):17162-72
references.pmid: 8394332
references.citation: FEBS J. 2011 Jun;278(12):1980-9
references.pmid: 21362139
references.citation: Mol Cell Biol. 1999 Sep;19(9):6297-305
references.pmid: 10454576
references.citation: Trends Biochem Sci. 2011 Nov;36(11):593-603
references.pmid: 21798744
references.citation: J Immunol. 1992 Apr 15;148(8):2417-22
references.pmid: 1532814
references.citation: J Biol Chem. 2000 Aug 4;275(31):23911-8
references.pmid: 10801816
references.citation: Biophys J. 2009 Apr 8;96(7):2604-23
references.pmid: 19348745
references.citation: Trends Immunol. 2013 Jun;34(6):259-68
references.pmid: 23506953
references.citation: Mol Cell Biol. 1999 Jun;19(6):4279-88
references.pmid: 10330169
references.citation: J Med Genet. 2007 Oct;44(10):651-6
references.pmid: 17586837
references.citation: Mol Biol Cell. 2007 Aug;18(8):3156-68
references.pmid: 17567957
references.citation: Bioorg Med Chem. 2004 Sep 1;12(17):4575-83
references.pmid: 15358285
references.citation: J Biol Chem. 1995 Jul 7;270(27):15954-7
references.pmid: 7608150
references.citation: Mol Cell Biol. 2012 Jul;32(14):2748-59
references.pmid: 22586275
references.citation: Nat Struct Mol Biol. 2006 Sep;13(9):798-805
references.pmid: 16906159
references.citation: Nat Cell Biol. 2002 May;4(5):343-50
references.pmid: 11988737
references.citation: Nature. 1998 Sep 3;395(6697):82-6
references.pmid: 9738502
references.citation: Mol Biol Cell. 2004 Jun;15(6):2932-42
references.pmid: 15064353
references.citation: Immunity. 2006 May;24(5):535-46
references.pmid: 16713972
references.citation: Mol Cell Biol. 2007 Apr;27(7):2732-45
references.pmid: 17283063
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7
references.pmid: 14681473
references.citation: Science. 1998 Jan 23;279(5350):560-3
references.pmid: 9438849
references.citation: Science. 2002 Jan 11;295(5553):325-8
references.pmid: 11729268
references.citation: J Cell Biol. 2002 Apr 15;157(2):253-63
references.pmid: 11956228
references.citation: Nat Struct Mol Biol. 2008 May;15(5):452-61
references.pmid: 18454158
references.citation: J Biol Chem. 1994 Feb 11;269(6):3913-6
references.pmid: 8307946
references.citation: Structure. 2003 Dec;11(12):1583-93
references.pmid: 14656442
references.citation: Int Immunol. 2007 Mar;19(3):239-48
references.pmid: 17220479
references.citation: Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31
references.pmid: 18568040
references.citation: Nat Immunol. 2005 Jun;6(6):608-17
references.pmid: 15864311
references.citation: PLoS One. 2013;8(1):e53300
references.pmid: 23308188
references.citation: J Immunol. 2009 Oct 15;183(8):4838-42
references.pmid: 19801509
references.citation: J Biol Chem. 2000 Jul 28;275(30):23355-61
references.pmid: 10811803
references.citation: Curr Biol. 1999 Mar 11;9(5):265-8
references.pmid: 10074452
references.citation: Oncogene. 2005 Apr 14;24(16):2695-704
references.pmid: 15829980
references.citation: Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12
references.pmid: 21746917
references.citation: Cell. 2009 Jan 23;136(2):337-51
references.pmid: 19167334
references.citation: Curr Biol. 2000 Oct 5;10(19):1225-8
references.pmid: 11050394
references.citation: Cell. 2007 Jun 1;129(5):957-68
references.pmid: 17540175
references.citation: Curr Biol. 1998 Jul 30-Aug 13;8(16):935-8
references.pmid: 9707409
references.citation: J Immunol. 2010 Sep 15;185(6):3536-43
references.pmid: 20713885
references.citation: J Cell Biol. 2005 Jul 18;170(2):261-72
references.pmid: 16027222
references.citation: EMBO J. 1995 Jan 16;14(2):276-85
references.pmid: 7835338
references.citation: PLoS One. 2011;6(11):e27511
references.pmid: 22132106
references.citation: Blood. 2000 May 15;95(10):3199-203
references.pmid: 10807788
references.citation: Genes Cancer. 2011 Mar;2(3):261-74
references.pmid: 21779497
references.citation: EMBO Rep. 2012 Apr;13(4):386-91
references.pmid: 22344067
references.citation: FEBS Lett. 2002 Feb 20;513(1):107-13
references.pmid: 11911888
references.citation: Nat Rev Immunol. 2007 Sep;7(9):690-702
references.pmid: 17703229
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16612-7
references.pmid: 15545601
references.citation: Am J Pathol. 2009 Jul;175(1):392-9
references.pmid: 19497993
references.citation: J Cell Biol. 2002 Jan 7;156(1):125-36
references.pmid: 11777939
references.citation: Cancer Res. 2007 Jan 1;67(1):276-80
references.pmid: 17210708
references.citation: Biochim Biophys Acta. 2009 Mar;1793(3):447-61
references.pmid: 19168098
references.citation: J Med Genet. 2009 Aug;46(8):553-4
references.pmid: 19465406
references.citation: Curr Opin Cell Biol. 2006 Aug;18(4):351-7
references.pmid: 16781855
references.citation: Cell Cycle. 2008 Dec;7(23):3634-40
references.pmid: 19029810
references.citation: J Exp Med. 1996 Jul 1;184(1):31-40
references.pmid: 8691147
references.citation: Nature. 1993 May 6;363(6424):45-51
references.pmid: 8479536
references.citation: Nat Immunol. 2002 Nov;3(11):1090-6
references.pmid: 12389041
references.citation: J Biol Chem. 2012 Mar 9;287(11):8135-43
references.pmid: 22262848
references.citation: Curr Opin Cell Biol. 2006 Apr;18(2):162-7
references.pmid: 16488589
references.citation: J Biol Chem. 2000 Oct 13;275(41):32260-7
references.pmid: 10918068
references.citation: Sci STKE. 2002 Aug 13;2002(145):pe36
references.pmid: 12177507
references.citation: Mol Cell Biol. 2001 Mar;21(5):1444-52
references.pmid: 11238881
references.citation: J Immunol Methods. 2013 Jan 31;387(1-2):276-83
references.pmid: 23178863
references.citation: J Immunol. 2011 Aug 1;187(3):1440-7
references.pmid: 21705626
references.citation: J Cell Biol. 2003 Jan 6;160(1):17-23
references.pmid: 12515821
references.citation: J Biol Chem. 2007 Nov 30;282(48):35396-404
references.pmid: 17911109
references.citation: Oncogene. 1996 Mar 7;12(5):1063-8
references.pmid: 8649797
references.citation: Proteomics. 2007 Jun;7(11):1775-85
references.pmid: 17474147
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16632-7
references.pmid: 16267129
references.citation: Immunology. 1997 Feb;90(2):250-6
references.pmid: 9135554
references.citation: Nat Rev Mol Cell Biol. 2012 Feb 23;13(3):195-203
references.pmid: 22358332
references.citation: Cell Signal. 2008 Apr;20(4):758-70
references.pmid: 18249095
references.citation: Nat Immunol. 2000 Oct;1(4):317-21
references.pmid: 11017103
references.citation: Curr Biol. 2005 May 10;15(9):869-73
references.pmid: 15886107
references.citation: Nat Rev Mol Cell Biol. 2011 Dec 22;13(1):39-51
references.pmid: 22189424
references.citation: Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):528-33
references.pmid: 19098101
references.citation: Sci Signal. 2010 Sep 21;3(140):ra68
references.pmid: 20858867
references.citation: Mol Cell Biol. 2013 Jun;33(12):2470-84
references.pmid: 23589333
references.citation: Nat Immunol. 2006 Nov;7(11):1174-81
references.pmid: 17028587
references.citation: Immunity. 2003 Nov;19(5):669-78
references.pmid: 14614854
references.citation: Cell. 2003 Mar 7;112(5):685-95
references.pmid: 12628188
references.citation: Nat Genet. 1995 Jul;10(3):294-300
references.pmid: 7670467
references.citation: Mol Cell Biol. 2007 Dec;27(23):8127-42
references.pmid: 17923690
references.citation: Chem Biol. 1995 Jan;2(1):53-60
references.pmid: 9383403
references.citation: Nature. 2001 Mar 1;410(6824):37-40
references.pmid: 11242034
references.citation: Front Immunol. 2013 Jul 04;4:178
references.pmid: 23847619
references.citation: Exp Cell Res. 2005 Sep 10;309(1):1-11
references.pmid: 15953601
references.citation: Mol Cell Biol. 2002 Jun;22(12):4073-85
references.pmid: 12024021
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3436-40
references.pmid: 20133694
references.citation: Biochem J. 2007 Sep 1;406(2):223-36
references.pmid: 17523924
references.citation: Eur J Immunol. 2007 Sep;37(9):2539-48
references.pmid: 17683112
references.citation: Oncogene. 1995 Oct 5;11(7):1417-26
references.pmid: 7478566
references.citation: Curr Opin Immunol. 2000 Jun;12(3):242-9
references.pmid: 10781399
references.citation: Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7118-23
references.pmid: 10840066
references.citation: Nat Cell Biol. 2006 Nov;8(11):1303-9
references.pmid: 17041586
references.citation: Curr Opin Immunol. 2000 Jun;12(3):282-8
references.pmid: 10781397
references.citation: Oncogene. 1987;1(3):305-14
references.pmid: 3133625
references.citation: Nature. 1995 Feb 16;373(6515):620-3
references.pmid: 7854419
references.citation: Nat Immunol. 2003 Mar;4(3):248-54
references.pmid: 12577055
references.citation: J Biol Chem. 1995 Sep 8;270(36):20883-6
references.pmid: 7673108
references.citation: Mol Biol Cell. 2011 Nov;22(22):4406-14
references.pmid: 21937721
references.citation: J Biol Chem. 1996 Mar 8;271(10):5871-7
references.pmid: 8621459
references.citation: Nat Immunol. 2011 May;12(5):425-33
references.pmid: 21441934
references.citation: Mol Cell. 2006 Feb 17;21(4):481-93
references.pmid: 16483930
references.citation: Mol Cell Biol. 1993 Dec;13(12):7718-24
references.pmid: 8246988
references.citation: Nat Chem Biol. 2010 Jun;6(6):449-56
references.pmid: 20418879
references.citation: Nat Immunol. 2002 Nov;3(11):1082-9
references.pmid: 12389042
references.citation: Nat Cell Biol. 2007 Jun;9(6):706-12
references.pmid: 17486115
references.citation: J Cell Sci. 2005 Oct 15;118(Pt 20):4879-88
references.pmid: 16219693
references.citation: Methods Enzymol. 1995;255:195-220
references.pmid: 8524103
references.citation: Cell. 1999 Jul 9;98(1):69-80
references.pmid: 10412982
references.citation: J Biol Chem. 1993 Jan 15;268(2):923-9
references.pmid: 8419371
references.citation: Cell. 1980 Apr;19(4):1005-14
references.pmid: 6247068
references.citation: Front Immunol. 2013 Apr 08;4:84
references.pmid: 23579783
references.citation: Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16692-7
references.pmid: 17075039
references.citation: Curr Biol. 2001 Nov 27;11(23):1880-4
references.pmid: 11728312
references.citation: Cell. 2007 Jun 1;129(5):865-77
references.pmid: 17540168
references.citation: J Immunol. 2005 Dec 1;175(11):7179-84
references.pmid: 16301621
references.citation: Lancet. 2013 Jan 26;381(9863):333-42
references.pmid: 23312968
references.citation: Blood. 2011 May 12;117(19):5102-11
references.pmid: 21444916
references.citation: Eur J Immunol. 2000 Aug;30(8):2378-87
references.pmid: 10940929
references.citation: Nat Cell Biol. 2002 Aug;4(8):E188-90
references.pmid: 12149627
references.citation: Blood. 2011 Mar 10;117(10):2747-8
references.pmid: 21393497
references.citation: Immunity. 2011 Nov 23;35(5):705-20
references.pmid: 22055681
references.citation: Blood. 2005 May 1;105(9):3648-54
references.pmid: 15657177
references.citation: Science. 2002 Jan 11;295(5553):290-1
references.pmid: 11786634
references.citation: Mol Immunol. 2008 Jan;45(2):510-22
references.pmid: 17658605
references.citation: Curr Biol. 2006 Nov 7;16(21):2173-9
references.pmid: 17084704
references.citation: Genes Cancer. 2011 Mar;2(3):320-34
references.pmid: 21779502
references.citation: PLoS One. 2008 Jan 30;3(1):e1521
references.pmid: 18231606
references.citation: Hum Mutat. 2011 Jul;32(7):760-72
references.pmid: 21387466
references.citation: Nat Rev Cancer. 2007 Apr;7(4):295-308
references.pmid: 17384584
references.citation: J Biol Chem. 1998 Jun 19;273(25):15830-7
references.pmid: 9624183
references.citation: Science. 1998 May 15;280(5366):1082-6
references.pmid: 9582122
references.citation: Science. 1995 Apr 7;268(5207):100-2
references.pmid: 7701328
references.citation: Mol Cell Biol. 1996 Oct;16(10):5674-82
references.pmid: 8816480
references.citation: Sci Signal. 2013 Mar 26;6(268):ra21
references.pmid: 23532335
references.citation: J Biol Chem. 2002 Aug 23;277(34):30508-14
references.pmid: 11880369
references.citation: Nat Genet. 2007 Jan;39(1):70-4
references.pmid: 17143285
references.citation: Mol Cell Biol. 2005 Jun;25(11):4426-41
references.pmid: 15899849
references.citation: Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10620-5
references.pmid: 20498059
references.citation: Int J Biochem Cell Biol. 2002 Feb;34(2):158-68
references.pmid: 11809418
references.citation: Nat Cell Biol. 2007 Jun;9(6):713-9
references.pmid: 17486117
references.citation: Immunity. 2002 Nov;17(5):617-27
references.pmid: 12433368
references.citation: Blood. 2005 Feb 15;105(4):1448-55
references.pmid: 15507521
references.citation: Science. 2008 Mar 14;319(5869):1539-43
references.pmid: 18339942
references.citation: J Struct Biol. 2008 Sep;163(3):258-69
references.pmid: 18342539
references.citation: Nature. 2003 Aug 7;424(6949):694-8
references.pmid: 12845332
references.citation: Biochem J. 2000 Aug 15;350 Pt 1:1-18
references.pmid: 10926821
references.citation: Blood. 2011 Mar 10;117(10):2883-6
references.pmid: 21079152
references.citation: Cancer Res. 1989 Sep 1;49(17):4682-9
references.pmid: 2547513
references.citation: J Exp Pathol. 1987;3(3):305-15
references.pmid: 2835467
references.citation: Nature. 1998 Jul 23;394(6691):337-43
references.pmid: 9690470
references.citation: Nat Genet. 2002 Sep;32(1):166-74
references.pmid: 12185365
references.citation: Blood. 2011 Mar 10;117(10):2887-90
references.pmid: 21063026
references.citation: Nature. 1993 May 6;363(6424):85-8
references.pmid: 8479541
references.citation: Semin Cell Dev Biol. 2012 Apr;23(2):145-53
references.pmid: 21924373
references.citation: Science. 2003 Mar 21;299(5614):1859-63
references.pmid: 12649474
references.citation: J Biol Chem. 2001 Aug 3;276(31):29588-95
references.pmid: 11395491
references.citation: J Exp Med. 1998 Oct 5;188(7):1287-95
references.pmid: 9763608
references.citation: J Biol Chem. 1997 Nov 28;272(48):30340-4
references.pmid: 9374522
references.citation: Cancer Res. 2010 Oct 15;70(20):7905-17
references.pmid: 20876802
references.citation: Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83
references.pmid: 9789079
references.citation: Cell. 1998 Oct 16;95(2):259-68
references.pmid: 9790532
references.citation: Nat Rev Immunol. 2010 Apr;10(4):257-71
references.pmid: 20336153
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3430-5
references.pmid: 20133692
references.citation: J Biol Chem. 2003 Dec 26;278(52):52792-801
references.pmid: 14532295
references.citation: Biochem J. 2007 Jul 15;405(2):199-221
references.pmid: 17590154
references.citation: Cell. 2013 Feb 28;152(5):1008-20
references.pmid: 23452850
references.citation: Cell. 1994 Sep 23;78(6):949-61
references.pmid: 7923364
references.citation: Oncogene. 2004 Jul 29;23(34):5823-33
references.pmid: 15184873
references.citation: J Exp Med. 2003 Dec 15;198(12):1841-51
references.pmid: 14676298