title: Intramolecular arylation of amino acid enolates.
abstract: Dianionic enolates formed from N'-aryl urea derivatives of amino acids undergo intramolecular C-arylation by attack of the enolate anion on the N'-aryl ring, leading to a hydantoin derivative of a quaternary amino acid. In situ IR studies allow identification of four intermediates on the reaction pathway.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Rd., Manchester M13 9PL, UK. clayden@man.ac.uk.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Atkinson
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Leonard
authors.forename: Julien
authors.initials: J
authors.lastname: Maury
authors.forename: Daniele
authors.initials: D
authors.lastname: Castagnolo
authors.forename: Nicole
authors.initials: N
authors.lastname: Volz
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clayden
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000838:Anions / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D000838:Anions; D007659:Ketones