title: Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.
abstract: Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras-MEK-MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network.
authors.affiliation: Center for Neural Science, New York University, New York, New York 10003, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Kopec
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Carew
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
references.citation: Eur J Neurosci. 2004 Nov;20(10):2671-80
references.pmid: 15548210
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13208-13
references.pmid: 16924103
references.citation: Trends Neurosci. 2002 Mar;25(3):160-5
references.pmid: 11852149
references.citation: Curr Opin Neurobiol. 2004 Jun;14(3):311-7
references.pmid: 15194111
references.citation: Pharmacol Biochem Behav. 1998 Aug;60(4):809-16
references.pmid: 9700962
references.citation: J Neurosci Res. 2012 Sep;90(9):1743-55
references.pmid: 22535512
references.citation: Annu Rev Pharmacol Toxicol. 2002;42:135-63
references.pmid: 11807168
references.citation: Trends Neurosci. 1996 Nov;19(11):514-20
references.pmid: 8931279
references.citation: Mol Cell Biol. 2009 Mar;29(5):1338-53
references.pmid: 19114553
references.citation: Learn Mem. 2011 Jul 26;18(8):534-44
references.pmid: 21791566
references.citation: Eur J Neurosci. 2011 Oct;34(7):1053-61
references.pmid: 21895802
references.citation: Brain Res. 1995 May 8;679(1):99-109
references.pmid: 7648270
references.citation: Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):580-4
references.pmid: 1846448
references.citation: Neurobiol Learn Mem. 2010 May;93(4):546-53
references.pmid: 20176121
references.citation: J Neurobiol. 1989 Jan;20(1):1-9
references.pmid: 2921606
references.citation: Neuron. 2008 Jun 12;58(5):708-19
references.pmid: 18549783
references.citation: J Neurosci. 2009 Jun 24;29(25):8206-14
references.pmid: 19553460
references.citation: Learn Mem. 2008 Oct 02;15(10):762-76
references.pmid: 18832563
references.citation: Brain Res Rev. 2007 Apr;54(1):80-91
references.pmid: 17229467
references.citation: Physiol Rev. 2009 Apr;89(2):607-48
references.pmid: 19342615
references.citation: Cell Mol Life Sci. 2006 May;63(9):963-74
references.pmid: 16596335
references.citation: Nat Neurosci. 2012 Dec;15(12):1707-14
references.pmid: 23160045
references.citation: J Neurosci. 2007 Dec 12;27(50):13701-5
references.pmid: 18077681
references.citation: Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78
references.pmid: 11252892
references.citation: Nature. 2010 Feb 18;463(7283):948-52
references.pmid: 20164928
references.citation: J Neurosci. 2004 May 19;24(20):4796-806
references.pmid: 15152040
references.citation: Neuron. 1999 Jun;23(2):353-64
references.pmid: 10399940
references.citation: Neurosci Res. 1991 Nov;12(3):403-11
references.pmid: 1664922
references.citation: J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:188-202
references.pmid: 21199531
references.citation: Cytokine Growth Factor Rev. 2005 Apr;16(2):233-47
references.pmid: 15863038
references.citation: Eur J Neurosci. 1995 Jan 1;7(1):160-8
references.pmid: 7711931
references.citation: J Neurosci. 2003 May 1;23(9):3899-907
references.pmid: 12736359
references.citation: Nature. 1987 Sep 3-9;329(6134):65-8
references.pmid: 3627243
references.citation: Nat Rev Mol Cell Biol. 2010 Jun;11(6):414-26
references.pmid: 20495582
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20511-6
references.pmid: 19075231
references.citation: J Exp Biol. 2003 May;206(Pt 10):1605-13
references.pmid: 12682092
references.citation: Nat Rev Neurosci. 2012 Jun 20;13(7):478-90
references.pmid: 22714019
references.citation: Neurosci Res. 2008 Aug;61(4):335-46
references.pmid: 18550187
references.citation: Neurobiol Dis. 2009 Mar;33(3):358-68
references.pmid: 19095063
references.citation: Eur J Neurosci. 2000 Jan;12(1):106-16
references.pmid: 10651865
references.citation: J Biol Chem. 2000 Jul 21;275(29):22583-9
references.pmid: 10807918
references.citation: Neuron. 2007 Jan 18;53(2):261-77
references.pmid: 17224407
references.citation: Learn Mem. 2011 Jan 18;18(2):108-17
references.pmid: 21245212
references.citation: J Biol Chem. 1988 Oct 5;263(28):14211-5
references.pmid: 2971654
references.citation: Nat Med. 1995 Jan;1(1):53-8
references.pmid: 7584953
references.citation: Nat Neurosci. 2002 Nov;5(11):1177-84
references.pmid: 12368805
references.citation: Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18162-7
references.pmid: 23071303
references.citation: J Neurosci. 2012 Apr 18;32(16):5688-703
references.pmid: 22514330
references.citation: Endocr Relat Cancer. 2001 Mar;8(1):11-31
references.pmid: 11350724
references.citation: Trends Neurosci. 2011 Aug;34(8):421-9
references.pmid: 21742388
references.citation: Development. 2003 Oct;130(20):4769-84
references.pmid: 12952899
references.citation: J Neurosci. 2001 Feb 1;21(3):1047-55
references.pmid: 11157090
references.citation: Neuron. 2001 Jul 19;31(1):143-54
references.pmid: 11498057
references.citation: J Neurochem. 2004 May;89(4):844-52
references.pmid: 15140184
references.citation: Genes Dev. 1994 Dec 15;8(24):2953-63
references.pmid: 8001817
references.citation: J Clin Endocrinol Metab. 2001 Aug;86(8):3665-74
references.pmid: 11502794
references.citation: J Neurosci. 2012 Oct 24;32(43):14885-98
references.pmid: 23100411
references.citation: J Neurosci. 2003 May 1;23(9):3679-88
references.pmid: 12736339
references.citation: Parkinsonism Relat Disord. 2002 Jun;8(5):311-23
references.pmid: 15177060
references.citation: J Neurosci. 1997 May 15;17(10):3796-803
references.pmid: 9133398
references.citation: Neuron. 2011 Jul 14;71(1):117-30
references.pmid: 21745642
references.citation: Mol Brain. 2008 Jun 17;1:3
references.pmid: 18803855
references.citation: Neurobiol Learn Mem. 2007 Nov;88(4):445-50
references.pmid: 17720555
references.citation: J Neurosci. 2009 Sep 2;29(35):10883-9
references.pmid: 19726646
references.citation: Brain Res Brain Res Rev. 2004 Mar;44(2-3):117-40
references.pmid: 15003389
references.citation: J Biol Chem. 2000 Oct 6;275(40):30765-73
references.pmid: 10843986
references.citation: J Neurosci. 2002 May 1;22(9):RC220
references.pmid: 11978861
references.citation: Science. 2008 Mar 21;319(5870):1683-7
references.pmid: 18309046
references.citation: Annu Rev Physiol. 1993;55:397-426
references.pmid: 8466181
references.citation: Nature. 2011 Jan 27;469(7331):491-7
references.pmid: 21270887
references.citation: FEBS Lett. 2012 Jul 4;586(14):1929-41
references.pmid: 22710177
references.citation: Physiol Rev. 2009 Jan;89(1):121-45
references.pmid: 19126756
references.citation: Neuron. 2003 Feb 6;37(3):473-84
references.pmid: 12575954
references.citation: Eur J Neurosci. 2006 Jun;23(12):3375-84
references.pmid: 16820027
references.citation: J Neurosci. 1997 Apr 1;17(7):2543-50
references.pmid: 9065514
references.citation: J Biol Chem. 2012 Nov 30;287(49):41432-45
references.pmid: 23055518
references.citation: Nature. 2009 Dec 17;462(7275):915-9
references.pmid: 19946267
references.citation: J Physiol. 2012 Jan 1;590(1):193-208
references.pmid: 22083603
references.citation: Nat Rev Neurosci. 2005 Apr;6(4):277-84
references.pmid: 15803159
references.citation: Neurobiol Learn Mem. 2008 Mar;89(3):285-92
references.pmid: 17962049
references.citation: Learn Mem. 2004 Jan-Feb;11(1):43-9
references.pmid: 14747516
references.citation: J Neurosci. 2012 Feb 8;32(6):2002-12
references.pmid: 22323714
references.citation: Nat Rev Neurosci. 2005 Aug;6(8):615-25
references.pmid: 16062170
references.citation: J Neurochem. 2006 Dec;99(5):1328-37
references.pmid: 17064361
references.citation: Cell. 1994 Oct 7;79(1):49-58
references.pmid: 7923376
references.citation: Nat Rev Neurosci. 2004 Jan;5(1):45-54
references.pmid: 14708003
references.citation: Learn Mem. 2010 Mar 23;17(4):176-85
references.pmid: 20332189
references.citation: Annu Rev Biochem. 2003;72:609-42
references.pmid: 12676795
references.citation: J Cell Sci. 2007 Nov 1;120(Pt 21):3830-7
references.pmid: 17940062
references.citation: Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96
references.pmid: 16493415
references.citation: Proc Natl Acad Sci U S A. 1954 Oct;40(10):1014-8
references.pmid: 16589582
references.citation: Nat Neurosci. 1998 Nov;1(7):602-9
references.pmid: 10196568
references.citation: Nat Neurosci. 2005 Feb;8(2):164-72
references.pmid: 15665879
references.citation: Physiol Behav. 2000 Feb;68(4):509-14
references.pmid: 10713291
references.citation: Neuron. 1997 Jun;18(6):899-912
references.pmid: 9208858
references.citation: Development. 1994 Jun;120(6):1621-9
references.pmid: 8050368
references.citation: Behav Brain Res. 2011 Aug 10;221(2):515-26
references.pmid: 20170684
references.citation: Cell. 2009 Oct 2;139(1):186-98
references.pmid: 19804763
references.citation: Neuroscience. 1999;93(4):1491-506
references.pmid: 10501474
references.citation: Eur J Neurosci. 2001 Feb;13(3):633-8
references.pmid: 11168572
references.citation: Neuron. 2006 Jun 1;50(5):765-79
references.pmid: 16731514
references.citation: J Biol Chem. 1995 Sep 1;270(35):20748-53
references.pmid: 7657657
references.citation: Exp Neurol. 2004 Apr;186(2):221-34
references.pmid: 15026258
references.citation: Cell. 2004 Feb 6;116(3):467-79
references.pmid: 15016380
references.citation: Neuroscientist. 2005 Aug;11(4):323-33
references.pmid: 16061519
references.citation: Neuroscience. 2011 Aug 25;189:156-69
references.pmid: 21624434
references.citation: Eur J Neurosci. 1993 Jul 1;5(7):927-32
references.pmid: 7506615
references.citation: Science. 1997 Feb 28;275(5304):1318-20
references.pmid: 9036859
references.citation: PLoS One. 2012;7(5):e37555
references.pmid: 22666365
references.citation: Genes Dev. 2009 Jan 1;23(1):1-11
references.pmid: 19136621
references.citation: J Biol Chem. 2000 Aug 25;275(34):26178-86
references.pmid: 10816576
references.citation: Nat Rev Neurosci. 2013 Jan;14(1):7-23
references.pmid: 23254191
references.citation: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13445-52
references.pmid: 8942955
references.citation: J Neurobiol. 2005 Feb 5;62(2):278-88
references.pmid: 15514998
references.citation: Pharmacol Biochem Behav. 2005 Jan;80(1):63-7
references.pmid: 15652381
references.citation: Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2711-6
references.pmid: 18263738
references.citation: Hippocampus. 2012 Jun;22(6):1371-8
references.pmid: 21997856
references.citation: Prog Brain Res. 2008;169:179-98
references.pmid: 18394474
references.citation: Biochim Biophys Acta. 1995 Jul 17;1241(2):177-94
references.pmid: 7640295
references.citation: Hippocampus. 2012 Nov;22(11):2127-35
references.pmid: 22573708
references.citation: J Neural Transm Park Dis Dement Sect. 1995;9(1):1-14
references.pmid: 7605586
references.citation: Acta Neurobiol Exp (Wars). 1993;53(1):197-207
references.pmid: 8317248
references.citation: Prog Neurobiol. 2002 Oct;68(3):209-45
references.pmid: 12450488
references.citation: Curr Opin Neurobiol. 2006 Dec;16(6):672-8
references.pmid: 17097872
references.citation: Biol Psychiatry. 2006 Jun 15;59(12):1128-35
references.pmid: 16631131
references.citation: J Neurosci. 1991 Jul;11(7):1889-906
references.pmid: 1648601
references.citation: J Neurosci. 2010 Jun 16;30(24):8221-8
references.pmid: 20554873
references.citation: Nat Rev Neurosci. 2005 Feb;6(2):119-30
references.pmid: 15685217
references.citation: J Neurosci. 1996 Sep 1;16(17):5437-42
references.pmid: 8757256
references.citation: Neuron. 1997 Nov;19(5):1031-47
references.pmid: 9390517
references.citation: Cell. 2003 Feb 7;112(3):303-15
references.pmid: 12581521
references.citation: J Neurosci. 2013 Apr 24;33(17):7565-73
references.pmid: 23616561
references.citation: Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1545-64
references.pmid: 16939974
references.citation: Behav Neurosci. 1995 Apr;109(2):278-84
references.pmid: 7619317
references.citation: J Biol Chem. 2010 Jul 9;285(28):21615-24
references.pmid: 20452974
references.citation: Nat Med. 2000 Jul;6(7):812-5
references.pmid: 10888932
references.citation: Acta Neurobiol Exp (Wars). 2000;60(3):377-94
references.pmid: 11016081
references.citation: Nature. 2009 Dec 17;462(7275):920-4
references.pmid: 19946265
references.citation: Annu Rev Biochem. 1998;67:753-91
references.pmid: 9759503
references.citation: J Neurosci. 2000 Jun 15;20(12):4563-72
references.pmid: 10844026
references.citation: J Biol Chem. 1995 Mar 31;270(13):7117-24
references.pmid: 7706248
references.citation: Neurobiol Learn Mem. 2007 Nov;88(4):409-15
references.pmid: 17765576
references.citation: Learn Mem. 2010 Dec 17;18(1):19-23
references.pmid: 21169419
references.citation: Cell. 2003 Jan 24;112(2):257-69
references.pmid: 12553913
references.citation: Rev Neurosci. 2012;23(1):29-37
references.pmid: 22718611
references.citation: Cell. 1994 Oct 7;79(1):59-68
references.pmid: 7923378
references.citation: J Neurosci. 1997 Oct 1;17(19):7288-96
references.pmid: 9295375
references.citation: Brain Res. 1991 Apr 26;547(1):171-4
references.pmid: 1860069
references.citation: J Biol Chem. 1996 Mar 1;271(9):5251-7
references.pmid: 8617810
references.citation: Nature. 2009 Jan 15;457(7227):313-7
references.pmid: 19005470
references.citation: J Neurosci. 2007 May 30;27(22):5885-94
references.pmid: 17537959
references.citation: Biol Psychiatry. 2007 Sep 1;62(5):381-90
references.pmid: 17239352
references.citation: Neuron. 2009 Jan 15;61(1):113-25
references.pmid: 19146817
references.citation: Neuron. 2001 Sep 13;31(5):841-51
references.pmid: 11567621
references.citation: Neuroscience. 2006 Jul 7;140(3):823-33
references.pmid: 16650607
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14206-10
references.pmid: 16963562