title: Increased RP105-Negative B Cells in IgG4-Related Disease.
abstract: Four patients with IgG4-related disease (IgG4-RD) showed increased percentages of RP105-negative B cells in the peripheral blood. Case 1: A 66-year-old man having retroperitoneal fibrosis had 18.8% of RP105-negative B cells. Oral prednisolone improved the affected lesions and the percentage of RP105-negative B cells decreased (3.2%) after the treatment. Case 2: A 53-year-old man with retroperitoneal fibrosis had 27.9% of RP105-negative B cells. Case 3: A 38-year-old man with follicular hyperplasia showed increased percentage of RP105-negative B cells (8.3%). Case 4: A 60-year-old man with interstitial nephritis had 27.5% of RP105-negative B cells. The treatment decreased the numbers of RP105-negative B cells. Increased numbers of RP105-negatvie B cells is possibly associated with disease activity of IgG4-RD. Analysis of expression of RP105 on B cells may be helpful in evaluation of disease activity of IgG4-RD.
authors.affiliation: Division of Rheumatology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Koarada
authors.forename: S
authors.initials: S
authors.lastname: Tashiro
authors.forename: N
authors.initials: N
authors.lastname: Nagao
authors.forename: R
authors.initials: R
authors.lastname: Suematsu
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
keywords: IgG4-related disease; RP105-negative B cells; plasma cells; plasmablasts.
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