title: Genotypes and allele frequencies of angiotensin converting enzyme (ACE) insertion/deletion polymorphism among Omanis.
abstract: OBJECTIVE
  To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs.
  
  
  METHODS
  A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat.
  
  
  RESULTS
  The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium.
  
  
  CONCLUSIONS
  The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.
authors.affiliation: Departments of Medicine.
authors.forename: Ali T
authors.initials: AT
authors.lastname: Al-Hinai
authors.forename: Mohammed O
authors.initials: MO
authors.lastname: Hassan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Simsek
authors.forename: Hameeda
authors.initials: H
authors.lastname: Al-Barwani
authors.forename: Riad
authors.initials: R
authors.lastname: Bayoumi
keywords: Allele; genotype; hypertension; polymorphism
references.citation: J Hypertens. 1994 Aug;12(8):955-7
references.pmid: 7814855
references.citation: Nature. 1992 Oct 15;359(6396):641-4
references.pmid: 1328889
references.citation: Nat Genet. 1992 Apr;1(1):72-5
references.pmid: 1338766
references.citation: Am J Hum Genet. 1992 Jul;51(1):197-205
references.pmid: 1319114
references.citation: J Hypertens. 1993 Apr;11(4):345-8
references.pmid: 8390500
references.citation: Biochem Mol Biol Int. 1994 Dec;34(6):1271-5
references.pmid: 7696999
references.citation: J Hypertens. 1993 Mar;11(3):231-6
references.pmid: 8387080
references.citation: Hum Genet. 1994 Aug;94(2):207-9
references.pmid: 8045571
references.citation: Clin Genet. 1997 Mar;51(3):211-3
references.pmid: 9137889
references.citation: Hum Biol. 2006 Feb;78(1):103-8
references.pmid: 16900885
references.citation: Biochem Biophys Res Commun. 1992 Apr 15;184(1):9-15
references.pmid: 1314601
references.citation: J Clin Invest. 1990 Oct;86(4):1343-6
references.pmid: 1976655
references.citation: Diabetologia. 1996 Jan;39(1):97-102
references.pmid: 8720609
references.citation: PCR Methods Appl. 1993 Oct;3(2):120-1
references.pmid: 8268786
references.citation: J Hypertens. 1998 Apr;16(4):397-418
references.pmid: 9797185
references.citation: Cardiology. 1997 Jul-Aug;88(4):309-14
references.pmid: 9197423
references.citation: Br J Clin Pharmacol. 1994 Feb;37(2):212-4
references.pmid: 8186067
references.citation: Lancet. 1990 Mar 31;335(8692):765-74
references.pmid: 1969518
references.citation: Arterioscler Thromb Vasc Biol. 1997 Feb;17(2):252-6
references.pmid: 9081678
references.citation: N Engl J Med. 1998 May 28;338(22):1626
references.pmid: 9606122
references.citation: Lancet. 1993 Oct 30;342(8879):1073-5
references.pmid: 8105309
references.citation: Nucleic Acids Res. 1992 Mar 25;20(6):1433
references.pmid: 1313972
references.citation: Lancet. 1994 Feb 19;343(8895):482-3
references.pmid: 7905978