title: Functional dyspepsia today.
abstract: Functional dyspepsia (FD) is a disorder presenting with symptoms such as postprandial fullness, early satiety or epigastric pain. Although there is a 10 to 30% reported prevalence worldwide, there is currently no clear explanation of the pathophysiology behind this condition. Motility disorders, visceral hypersensitivity, acid disorders, Helicobacter pylori infection or psychosocial factors have all been reported to play a part in the pathophysiology of FD. The diagnosis of FD is one of exclusion, based on the Rome III criteria. The main therapeutic modalities include lifestyle changes, eradicating Helicobacter pylori infection and treatment with either proton pump inhibitors, prokinetics or antidepressants.
authors.affiliation: Department of Gastroenterology, Colentina Clinical Hospital, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Theodor Alexandru
authors.initials: TA
authors.lastname: Voiosu
authors.forename: Roxana
authors.initials: R
authors.lastname: Giurcan
authors.forename: Andrei Mihai
authors.initials: AM
authors.lastname: Voiosu
authors.forename: Mihail Radu
authors.initials: MR
authors.lastname: Voiosu
references.citation: Gut. 2008 Jun;57(6):740-6
references.pmid: 17965059
references.citation: Scand J Gastroenterol. 1996 Nov;31(11):1063-8
references.pmid: 8938898
references.citation: Am J Physiol. 1996 Oct;271(4 Pt 1):G591-7
references.pmid: 8897877
references.citation: Gastrointest Endosc. 2003 Mar;57(3):295-9
references.pmid: 12612505
references.citation: Arch Intern Med. 2000 Apr 24;160(8):1192-8
references.pmid: 10789614
references.citation: Gut. 1999 Jan;44(1):55-64
references.pmid: 9862826
references.citation: Am J Gastroenterol. 2002 Dec;97(12):3045-51
references.pmid: 12492188
references.citation: Am J Med. 2004 Jun 1;116(11):740-8
references.pmid: 15144910
references.citation: Clin Pediatr (Phila). 2006 Mar;45(2):143-7
references.pmid: 16528434
references.citation: Ann Intern Med. 1985 Feb;102(2):266-9
references.pmid: 3917639
references.citation: J Clin Gastroenterol. 2009 Sep;43(8):716-22
references.pmid: 19247205
references.citation: Am Fam Physician. 2011 Mar 1;83(5):547-52
references.pmid: 21391521
references.citation: Gastroenterol Clin North Am. 2003 Jun;32(2):477-506
references.pmid: 12858603
references.citation: Gastroenterology. 2006 Apr;130(5):1466-79
references.pmid: 16678560
references.citation: Gastrointest Endosc. 2007 Dec;66(6):1071-5
references.pmid: 18028927
references.citation: Lancet. 2000 Aug 5;356(9228):455-60
references.pmid: 10981888
references.citation: Gastroenterology. 2005 Nov;129(5):1753-5
references.pmid: 16285970
references.citation: Aliment Pharmacol Ther. 2003 Jun 15;17(12):1481-91
references.pmid: 12823150
references.citation: Lancet. 2009 Jan 17;373(9659):215-25
references.pmid: 19150702
references.citation: Chin J Dig Dis. 2006;7(4):181-5
references.pmid: 17054578
references.citation: Gastroenterol Clin North Am. 2007 Sep;36(3):649-64, xi-x
references.pmid: 17950442
references.citation: Aliment Pharmacol Ther. 1998 Nov;12(11):1055-65
references.pmid: 9845395
references.citation: Dig Dis Sci. 1997 Jun;42(6):1158-62
references.pmid: 9201077
references.citation: Clin Gastroenterol Hepatol. 2008 Jul;6(7):746-52; quiz 718
references.pmid: 18424191
references.citation: J Neurogastroenterol Motil. 2012 Apr;18(2):150-68
references.pmid: 22523724
references.citation: Clin Exp Allergy. 2007 Jun;37(6):823-30
references.pmid: 17517095
references.citation: Aliment Pharmacol Ther. 2004 Mar 15;19(6):631-41
references.pmid: 15023165
references.citation: Gastroenterol Clin North Am. 2003 Jun;32(2):577-99
references.pmid: 12858607
references.citation: Gastroenterology. 1998 Mar;114(3):582-95
references.pmid: 9496950
references.citation: Cochrane Database Syst Rev. 2000;(2):CD001960
references.pmid: 10796840
references.citation: Gen Hosp Psychiatry. 2010 Sep-Oct;32(5):499-502
references.pmid: 20851270
references.citation: Clin Gastroenterol Hepatol. 2010 Oct;8(10):830-7, 837.e1-2
references.pmid: 20541625
references.citation: Gut. 1995 Jul;37(1):17-22
references.pmid: 7672673
references.citation: Aliment Pharmacol Ther. 2007 Sep 1;26(5):673-82
references.pmid: 17697201
references.citation: Gut. 2007 Jun;56(6):772-81
references.pmid: 17170018
references.citation: Am Fam Physician. 1999 Oct 15;60(6):1773-84, 1787-8
references.pmid: 10537391
references.citation: J Neurogastroenterol Motil. 2012 Jul;18(3):246-57
references.pmid: 22837872
references.citation: Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002096
references.pmid: 16625554
references.citation: World J Gastroenterol. 2006 May 7;12(17):2661-6
references.pmid: 16718749
references.citation: J Clin Gastroenterol. 2009 Jul;43(6):527-33
references.pmid: 19318982
references.citation: Gut. 1995 Jul;37(1):47-51
references.pmid: 7672680
references.citation: Dig Dis Sci. 1995 Aug;40(8):1636-41
references.pmid: 7648962