title: Prognostic value of preoperative peripheral neutrophil-to-lymphocyte ratio in patients with HBV-associated hepatocellular carcinoma after radical hepatectomy.
abstract: Neutrophil-to-lymphocyte ratio (NLR), an inflammation index, is considered a prognostic predictor of hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic value of preoperative peripheral NLR in patients with hepatitis B virus (HBV)-associated HCC after radical hepatectomy. Clinical data were collected from patients with HBV-associated HCC who underwent radical hepatectomy. NLR was calculated from lymphocyte and neutrophil counts on preoperative routine blood tests. Demographics, laboratory analyses, and histopathological data were analyzed. A total of 282 patients were selected and divided by the cutoff NLR value of 2. Multivariate analysis showed that NLR > 2 was an independent prognostic predictor of poor disease-free survival [hazard ratio (HR) = 1.362; 95% confidence interval (CI) 1.025-1.811; P = 0.033] and overall survival (HR = 1.434; 95% CI 1.044-1.970; P = 0.023). NLR had a good predictive value for prognosis in patients with HBV-associated HCC who had normal serum AFP level. These results suggested that NLR is an independent indicator of both disease-free survival and overall survival in patients with HBV-associated HCC after radical hepatectomy, including AFP-normal patients.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, People's Republic of China.
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Fu
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Shen
authors.forename: Shao-Qiang
authors.initials: SQ
authors.lastname: Li
authors.forename: Yun-Peng
authors.initials: YP
authors.lastname: Hua
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Hu
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Liang
authors.forename: Bao-Gang
authors.initials: BG
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000821:virology; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000821:virology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D011379:Prognosis; D055815:Young Adult
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