title: [Procalcitonin change pattern in patients with septic shock and its relationship with prognosis].
abstract: OBJECTIVE
  To investigate procalcitonin (PCT) change pattern in patients with septic shock and its relationship with prognosis.
  
  
  METHODS
  Sixty-three septic shock patients were enrolled, and levels of PCT, C-reactive protein (CRP) as well as white blood cell (WBC) on 1st, 3rd, 5th,7th day after admission to intensive care unit (ICU) were checked. Patients were divided into survival group and death group according to 28-day survival result. Differences in parameters between two groups were compared. The change regulation of parameters along with in-hospital period and its relationship with prognosis were analyzed by multilevel linear model.
  
  
  RESULTS
  There were 41 patients in survival group and 22 patients in death group. PCT and CRP level decreased in survival group with time dependency pattern, while death group increased. The PCT at 3, 5, 7 days after admission to ICU in death group were significantly higher than those in survivors (3 days: 8.7±3.7 μg/L vs. 5.6±1.7 μg/L, 5 days: 10.3±1.3 μg/L vs. 4.8±2.3 μg/L, 7 days: 12.7±2.3 μg/L vs. 0.8±0.3 μg/L, P<0.05 or P<0.01), and CRP at 5 days and 7 days was significantly higher than those in survival group (5 days: 447±63 mg/L vs. 355±91 mg/L, 7 days: 439±45 mg/L vs. 364±63 mg/L, both P<0.05). Two groups of WBC did not change significantly, and there were no statistical significance difference at each time point between the two groups. What's more, the effect analysis results showed that there were significant changes in PCT as ICU day prolonged (F=10.91, P= 0.00), and there was a significant difference between the survivor and the dead (F=7.58, P=0.00), while CRP changed only with ICU stays (F=4.17, P=0.03).
  
  
  CONCLUSIONS
  Compared with CRP and WBC, PCT had higher sensitivity in predicting prognosis, sustainable elevation of PCT level indicates poor prognosis, serum PCT can be used as one of indexes predicting prognosis of septic shock.
authors.affiliation: Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China. Corresponding author: Zeng Hong-ke, Email: zenghongke@vip.163.com.
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Huang
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Miao-yun
authors.initials: MY
authors.lastname: Wen
authors.forename: Wen-qiang
authors.initials: WQ
authors.lastname: Jiang
authors.forename: Hong-ke
authors.initials: HK
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012772:Shock, Septic / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D015996:Survival Rate
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide