title: Regulation of the basolateral Na+, K+-ATPase in the activation of electrogenic Na+ absorption induced by isoproterenol in the rat distal colon.
abstract: We investigated the effects of cAMP on the basolateral Na(+), K(+)-ATPase and apical amiloride-sensitive Na(+) channel in the rat distal colon. Under mucosal treatment with nystatin, isoproterenol and forskolin increased the basolateral Na(+) pump current. Under serosal treatment with ouabain, both agents slightly increased the amiloride-sensitive Na current, but not to a significant level. We concluded that cAMP activates the basolateral Na(+), K(+)-ATPase in the rat distal colon.
authors.affiliation: Department of Home Economics, Tohoku Women's College.
authors.forename: Yo
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D007408:Intestinal Absorption / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol