title: High CDC20 expression is associated with poor prognosis in oral squamous cell carcinoma.
abstract: OBJECTIVE
  Human Cell Division Cycle 20 (CDC20) homolog is a crucial target of the spindle assembly checkpoint. It is an activator of the Anaphase-Promoting Complex/Cyclosome (APC/C) which promotes anaphase onset and mitotic exit through the ubiquitination of securin and cyclin B1. Overexpression of CDC20 was previously reported in oral squamous cell carcinoma (OSCC). Here, we propose to explore the clinicopathological significance of CDC20 overexpression and its potential use as a prognostic marker in OSCC.
  
  
  METHODS
  Using tissue microarray technology, we analyzed CDC20 expression in 65 primary OSCC tissues by immunohistochemistry. Statistical analysis was performed to evaluate the clinicopathological and prognostic significance of CDC20 expression in OSCC.
  
  
  RESULTS
  Of the 65 cases of patients with OSCC studied, 37 (56.9%) showed high CDC20 protein expression. No clinicopathological features were correlated with CDC20 expression. Importantly, in univariable analysis, OSCC patients with higher CDC20 protein expression showed significantly shorter cancer-specific survival rate (P = 0.018). Multivariable analysis identified high CDC20 expression as an independent prognostic factor (P = 0.032).
  
  
  CONCLUSIONS
  High CDC20 expression is associated with poor prognosis in OSCC and may be used to identify high-risk OSCC patients and may serve as a therapeutic target.
authors.affiliation: Centro de Investigação em Ciências da Saúde (CICS), Instituto Superior de Ciências da Saúde - Norte, CESPU, Gandra PRD, Portugal.
authors.forename: Inês M B
authors.initials: IM
authors.lastname: Moura
authors.forename: Maria L
authors.initials: ML
authors.lastname: Delgado
authors.forename: Patrícia M A
authors.initials: PM
authors.lastname: Silva
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Lopes
authors.forename: José B
authors.initials: JB
authors.lastname: do Amaral
authors.forename: Luís S
authors.initials: LS
authors.lastname: Monteiro
authors.forename: Hassan
authors.initials: H
authors.lastname: Bousbaa
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D064199:Cdc20 Proteins / Q000032:analysis*; D056744:Cyclin B1 / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D059566:M Phase Cell Cycle Checkpoints / Q000502:physiology; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D064249:Securin / Q000378:metabolism; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C534699:CCNB1 protein, human; D064199:Cdc20 Proteins; D056744:Cyclin B1; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human; C577488:CDC20 protein, human; D064173:Anaphase-Promoting Complex-Cyclosome
keywords: CDC20 expression; oral cavity cancer; prognostic marker; spindle assembly checkpoint