title: Repeated erythromycin/codeine-induced psychotic mania.
abstract: BACKGROUND
  Mania is generally associated with bipolar disorder; however, it can be iatrogenic. For instance, antibiotics and corticosteroids can cause manic symptoms.
  
  
  METHODS
  Here, we present a case of a young man who had symptoms of psychotic mania after administration of erythromycin and acetaminophen with codeine on 2 separate occasions, with rapid resolution of each episode.
  
  
  CONCLUSIONS
  Adverse events of psychotic mania have been rarely reported with erythromycin and acetaminophen with codeine, despite these being commonly prescribed medications. Clinicians should be aware that these drugs may be an iatrogenic cause of psychiatric disturbances and that these adverse events are more likely to occur during their concomitant use.
authors.affiliation: Departments of *Psychiatry, and †Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: Mirko
authors.initials: M
authors.lastname: Manchia
authors.forename: Martin
authors.initials: M
authors.lastname: Alda
authors.forename: Cynthia V
authors.initials: CV
authors.lastname: Calkin
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000700:Analgesics / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D003061:Codeine / Q000009:adverse effects*; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004917:Erythromycin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C526278:acetaminophen, codeine drug combination; D000082:Acetaminophen; D004917:Erythromycin; D003061:Codeine