title: Elevated serum iron is a potent biomarker for spirometric resistance to cigarette smoke among Japanese males: the Takahata study.
abstract: Chronic obstructive pulmonary disease is a common disability among elderly subjects with a heavy cigarette smoking habit. In contrast to the population that is susceptible to smoking, in whom pulmonary function worsens with the length of exposure to cigarette smoke, there are elderly individuals whose pulmonary function is not impaired. However, to date, the characteristics of this resistant smoking population have not been investigated. We aimed to identify a biomarker in individuals in whom lung health is maintained despite smoking. Blood sampling and spirometry were performed on 3,257 subjects who participated in a community-based annual health check in Takahata, Japan, from 2004 to 2006. We selected 117 elderly smokers (age ≥70, Brinkman index ≥600, smoking years ≥30). The 'smoking resistant' group met the following criteria: FEV1/FVC ≥0.7, and FEV1%predicted ≥80. Spirometry was re-evaluated in 147 male, current smokers in 2009. Baseline serum iron (sFe) levels were higher in the smoke resistant group compared with the non-resistant group. In those with low sFe levels, FEV1/FVC was reduced in male subjects. These spirometric measures were positively associated with sFe levels in men. Multiple linear regression analysis revealed that sFe levels were predictive for spirometric values, independent of other clinical factors. In addition, sFe levels were predictive for a decline in FEV1.Serum iron levels may be a biomarker for the spirometric susceptibility of individuals to cigarette smoke.
authors.affiliation: Department of Cardiology, Pulmonology and Nephrology, School of Medicine, Yamagata University, Yamagata City, Yamagata, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Kento
authors.initials: K
authors.lastname: Sato
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People; D015415:Biomarkers; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D007564:Japan; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011159:Population Surveillance; D012129:Respiratory Function Tests; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*; D013147:Spirometry
chemical_list: D015415:Biomarkers; D007501:Iron
references.citation: PLoS One. 2011;6(5):e19382
references.pmid: 21625484
references.citation: Am J Respir Crit Care Med. 2008 Dec 1;178(11):1130-8
references.pmid: 18723436
references.citation: Nihon Kokyuki Gakkai Zasshi. 2004 Nov;Suppl:1-56
references.pmid: 15565748
references.citation: Biochem Biophys Res Commun. 2011 Nov 18;415(2):284-7
references.pmid: 22027142
references.citation: Intern Med. 2010;49(15):1489-99
references.pmid: 20686279
references.citation: Eur Respir J. 2003 Jun;21(6):971-6
references.pmid: 12797490
references.citation: Am J Respir Cell Mol Biol. 2007 Feb;36(2):158-65
references.pmid: 16980551
references.citation: PLoS One. 2011 Feb 03;6(2):e16476
references.pmid: 21304900
references.citation: Am J Respir Crit Care Med. 2012 Oct 1;186(7):622-32
references.pmid: 22837378
references.citation: Int J Med Sci. 2011;8(6):470-8
references.pmid: 21850198
references.citation: Hum Mol Genet. 2012 Feb 15;21(4):947-57
references.pmid: 22080838
references.citation: Nutr Res Pract. 2008 Fall;2(3):184-90
references.pmid: 20126605
references.citation: Hum Mol Genet. 2012 Mar 15;21(6):1325-35
references.pmid: 22140090
references.citation: PLoS Genet. 2009 Mar;5(3):e1000421
references.pmid: 19300482
references.citation: Respir Res. 2008 Sep 29;9:67
references.pmid: 18823528
references.citation: Int J Med Sci. 2013;10(1):1-7
references.pmid: 23288999
references.citation: Eur Respir J. 2013 Jul;42(1):18-27
references.pmid: 23143543
references.citation: Respir Med. 2003 Feb;97(2):115-22
references.pmid: 12587960
references.citation: Nat Genet. 2008 Jun;40(6):695-701
references.pmid: 18509313
references.citation: Drug Metab Rev. 2007;39(2-3):619-26
references.pmid: 17786642
references.citation: N Engl J Med. 1988 Sep 29;319(13):874
references.pmid: 3412421
references.citation: Free Radic Biol Med. 1997;23(5):783-92
references.pmid: 9296456
references.citation: Am J Hum Genet. 2000 Jan;66(1):187-95
references.pmid: 10631150