title: Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population.
abstract: Genetic variation at 8q24 is associated with prostate, bladder, breast, colorectal, thyroid, lung, ovarian, UADT, liver and stomach cancers. However, a role for variation at 8q24 in familial clustering of upper gastrointestinal cancers has not been studied. In order to explore potential inherited susceptibility, we analyzed epidemiologic data from a population-based case-control study of upper gastrointestinal cancers from Taixing, China. The study population includes 204 liver, 206 stomach, and 218 esophageal cancer cases and 415 controls. Associations between 8q24 rs1447295, rs16901979, rs6983267 and these cancers were stratified by family history of cancer. Odds ratios and 95% confidence intervals were adjusted for potential confounders: age, sex, education, tobacco smoking, alcohol consumption, and BMI at interview. We also adjusted for hepatitis B and aflatoxin (liver cancer) and Helicobacter pylori (stomach cancer). In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80). Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer. When considered in a genetic risk score model, each additional 8q24 risk genotype increased the odds of liver cancer by two-fold among those with a family history of cancer (OR(adj) 2.00; 95% CI 1.15-3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility.
authors.affiliation: Department of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USA, heather.tarleton@lmu.edu.
authors.forename: Heather P
authors.initials: HP
authors.lastname: Tarleton
authors.forename: Shen-Chih
authors.initials: SC
authors.lastname: Chang
authors.forename: Sungshim Lani
authors.initials: SL
authors.lastname: Park
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
authors.forename: Baoguo
authors.initials: B
authors.lastname: Ding
authors.forename: Na
authors.initials: N
authors.lastname: He
authors.forename: Shehnaz K
authors.initials: SK
authors.lastname: Hussain
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Jiang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Mu
authors.forename: Jianyu
authors.initials: J
authors.lastname: Rao
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Nai-Chieh Y
authors.initials: NC
authors.lastname: You
authors.forename: Shun-Zhang
authors.initials: SZ
authors.lastname: Yu
authors.forename: Jin-Kou
authors.initials: JK
authors.lastname: Zhao
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics; D005190:Family; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
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