title: Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension.
abstract: The present study evaluated the effects of garlic on blood pressure in patients with essential hypertension. Patients (n=210) with stage 1 essential hypertension were divided into 7 groups named as A, B, C, D, E, F and G. Each group comprised of 30 patients. Each patient in group A, B, C, D and E has received garlic tablets at the dose of 300/mg. 600/mg, 900/mg, 1200/mg and 1500/mg in divided doses per day respectively for 24 weeks while Group F & group G were given tablet atenolol and placebo respectively. Blood pressure readings were recorded at weeks 0, 12 and 24. Present study showed significant decrease in both Systolic and Diastolic blood pressure in both dose and duration dependent manner. In each garlic treated group, significant reduction in SBP and DBP (p&lt;0.005) were observed when compared with atenolol (P&lt;0.005) and placebo.
authors.affiliation: Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
authors.forename: Rizwan
authors.initials: R
authors.lastname: Ashraf
authors.forename: Rafeeq Alam
authors.initials: RA
authors.lastname: Khan
authors.forename: Imran
authors.initials: I
authors.lastname: Ashraf
authors.forename: Absar A
authors.initials: AA
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003971:Diastole; D005260:Female; D005737:Garlic; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D016037:Single-Blind Method; D013599:Systole; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts