title: [An elderly patient with large cell neuroendocrine carcinoma(LCNEC)for whom chemotherapy with irinotecan and split-dose cisplatin(CDDP)proved very effective].
abstract: Large cell neuroendocrine carcinoma(LCNEC)is a rare malignant disease with a poor and the clinical outcome. Although no standard chemotherapy regimen has been developed, LCNEC should be treated in a manner similar to that used for small cell lung cancer because of their similar chemosensitivity and aggressive characteristics, even though LCNEC is classified as non-small cell lung cancer. A 78-year-old man was admitted with the complaint of convulsions on the left side of his body. A chest computed tomographic(CT)scan on admission demonstrated a 4 cm mass in a left lung S9. Brain magnetic resonance imaging(MRI)revealed enhanced tumors in the left occipital lobe. The brain tumor was surgically resected and histological findings were diagnosed as LCNEC. After induction of 4 courses with irinotecan and split-dose cisplatin chemotherapy, a partial response was obtained. After 4 courses, the tumor size was increased, and the chemotherapy was changed to amrubicin. The patient is alive and with no relapse.
authors.affiliation: Dept. of Respiratory Medicine, Sapporo Higashi Tokushukai Hospital, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Tanno
authors.forename: Hideki
authors.initials: H
authors.lastname: Onodera
authors.forename: Syoichi
authors.initials: S
authors.lastname: Inoue
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Honda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagashima
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ohsaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018287:Carcinoma, Large Cell / Q000188:drug therapy* / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008297:Male
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin