title: Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb.
abstract: Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynaptic GABA(B)-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABA(B) neuromodulation. Correlated with this functional change, we found altered localization of the GGABA(B)R1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb.
authors.affiliation: Laboratory for Perception and Memory and Integrative Neurobiology of Cholinergic Systems, Pasteur Institute, F-75015 Paris, France, and National Center of Scientific Research, Coeducational Research Unit, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3571, F-75015 Paris, France.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Valley
authors.forename: Lansdale G
authors.initials: LG
authors.lastname: Henderson
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Inverso
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lledo
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001426:Bacterial Proteins / Q000235:genetics; D000075402:Channelrhodopsins; D005260:Female; D018682:GABA Agents / Q000494:pharmacology; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000235:genetics; D008164:Luminescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology* / Q000254:growth & development; D018080:Receptors, GABA-B / Q000378:metabolism; D026941:Sodium Channel Blockers / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D016704:Synapsins / Q000235:genetics; D013779:Tetrodotoxin / Q000494:pharmacology; D014161:Transduction, Genetic; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D000075402:Channelrhodopsins; D018682:GABA Agents; D008164:Luminescent Proteins; D018080:Receptors, GABA-B; D026941:Sodium Channel Blockers; D016704:Synapsins; C054562:yellow fluorescent protein, Bacteria; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid
references.citation: J Neurosci. 2013 Feb 27;33(9):3738-43
references.pmid: 23447585
references.citation: Neuron. 1997 Sep;19(3):687-95
references.pmid: 9331358
references.citation: Nat Neurosci. 2003 May;6(5):507-18
references.pmid: 12704391
references.citation: Neuron. 2010 Jan 14;65(1):32-9
references.pmid: 20152111
references.citation: J Neurosci. 2008 Apr 9;28(15):3966-75
references.pmid: 18400896
references.citation: Neuron. 2013 Nov 20;80(4):1010-24
references.pmid: 24139818
references.citation: J Neurosci. 2007 Sep 12;27(37):9951-61
references.pmid: 17855609
references.citation: Neuron. 1998 Apr;20(4):749-61
references.pmid: 9581766
references.citation: J Neurosci. 2003 Mar 15;23(6):2032-9
references.pmid: 12657661
references.citation: Neuron. 2012 Dec 6;76(5):962-75
references.pmid: 23217744
references.citation: J Neurocytol. 2004 Jan;33(1):87-99
references.pmid: 15173634
references.citation: Neurobiol Aging. 2013 Jul;34(7):1873-81
references.pmid: 23419702
references.citation: Nat Neurosci. 2012 Jun;15(6):897-904
references.pmid: 22581183
references.citation: J Neurosci Methods. 2006 Mar 15;151(2):168-77
references.pmid: 16157388
references.citation: Nat Neurosci. 2009 Jun;12(6):731-3
references.pmid: 19412165
references.citation: J Neurosci. 2004 Jul 7;24(27):6086-97
references.pmid: 15240800
references.citation: J Neurosci. 2010 Dec 15;30(50):17023-34
references.pmid: 21159972
references.citation: J Neurosci. 2009 Sep 23;29(38):11852-8
references.pmid: 19776271
references.citation: Neuron. 2011 Sep 8;71(5):883-97
references.pmid: 21903081
references.citation: Eur J Neurosci. 1999 Mar;11(3):761-8
references.pmid: 10103070
references.citation: Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13924-9
references.pmid: 20643921
references.citation: J Neurosci. 2013 Feb 27;33(9):3780-5
references.pmid: 23447590
references.citation: Cell Tissue Res. 2005 Feb;319(2):181-9
references.pmid: 15654651
references.citation: Neuron. 2001 Jul 19;31(1):47-58
references.pmid: 11498050
references.citation: Nat Neurosci. 2009 Jun;12(6):728-30
references.pmid: 19412168