title: 2-{4-[(1,3-Benzodioxol-5-yl)meth-yl]piperazin-1-yl}pyrimidine.
abstract: In the title compound, C16H18N4O2, known also as peribedil, the dihedral angle between the mean planes of the pyrimidine and benzene rings is 56.5 (8)°. The 1,3-dioxole fragment adopts an envelope conformation with the methyl-ene C atom forming the flap; this atom deviates by 0.232 (3) Å from the plane defined by the remaining atoms of the 1,3-benzodioxole unit. In the crystal, C-H⋯π inter-actions between c-glide-related mol-ecules arrange them into columns extending along the c-axis direction. The columns related by a unit translation along the b axis are packed into (100) layers via another C-H⋯π inter-action involving the pyrimidine ring as an acceptor.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Wu
authors.forename: Jieming
authors.initials: J
authors.lastname: Li
authors.forename: Huijie
authors.initials: H
authors.lastname: Wei
authors.forename: Ye
authors.initials: Y
authors.lastname: Hang
authors.forename: Yueming
authors.initials: Y
authors.lastname: Jiang
references.citation: J Neurol. 1992;239 Suppl 1:S28-34
references.pmid: 1634909
references.citation: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references.pmid: 18156677