title: Correlation between CT-estimated tumor volume, pathologic tumor volume, and final pathologic specimen weight in children with Wilms' tumor.
abstract: OBJECTIVE
  To evaluate the relationship of Wilms' tumor (WT) volume to weight, and evaluate computed tomography (CT) scan-derived final pathologic specimen weight estimation models.
  
  
  METHODS
  We retrospectively reviewed WT patients from 2003 to 2011 who had a pre-operative CT scan, final pathologic specimen weight, and tumor dimensions. A partial nephrectomy tumor cohort (n = 12) was used derive WT density. A radical nephrectomy cohort (n = 45) was used to develop a simplified estimation equation of final pathologic specimen weight, and analysis of all known estimation models was performed.
  
  
  RESULTS
  Fifty-two patients were identified. WT volume and weight were not equivalent (p = 0.0410). WT density was 1.3091 g/cm(3). WT volume and final pathologic specimen weight were not significant (p = 0.0007). Our model (p = 0.9983) and CT estimated ellipsoidal volume (p = 0.0741) were able to estimate final pathologic specimen weight in all tumors. However, CT-estimated ellipsoidal volume failed to estimate final pathologic specimen weight in specimens < 250 g (p = 0.0066).
  
  
  CONCLUSIONS
  Pathologic WT volume is not equivalent to final pathologic specimen weight. Final pathologic specimen weight can be estimated from a pre-operative CT scan, which suggests that it may be used to improve pre-operative surgical planning and to reduce treatment morbidity.
authors.affiliation: Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., M/S C-319, Aurora, CO 80045, USA. Electronic address: thomas.pshak@ucdenver.edu.
authors.forename: T J
authors.initials: TJ
authors.lastname: Pshak
authors.affiliation: Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., M/S C-319, Aurora, CO 80045, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Cho
authors.affiliation: Department of Radiology, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO 80045, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Hayes
authors.affiliation: Department of Urology, Children's Hospital Colorado, 13123 East 16th Avenue Aurora, Aurora, CO 80045, USA.
authors.forename: V M
authors.initials: VM
authors.lastname: Vemulakonda
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden; D009396:Wilms Tumor / Q000000981:diagnostic imaging* / Q000473:pathology*
keywords: Diagnostic imaging; Tomography; Tumor volume; Wilms' tumor; X-ray computed