title: Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV.
abstract: Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.
authors.affiliation: Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan. Electronic address: wfischer@ym.edu.tw.
authors.forename: Wolfgang B
authors.initials: WB
authors.lastname: Fischer
authors.affiliation: Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.affiliation: Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Dhani Ram
authors.initials: DR
authors.lastname: Mahato
authors.affiliation: Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Wang
authors.affiliation: Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Chin-Pei
authors.initials: CP
authors.lastname: Chen
mesh_terms: D015703:Antigens, CD / Q000737:chemistry; D015704:CD4 Antigens / Q000737:chemistry; D058851:GPI-Linked Proteins / Q000737:chemistry; D054298:Human Immunodeficiency Virus Proteins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry; D009856:Oncogene Proteins, Viral / Q000737:chemistry*; D024683:Potassium Channels, Tandem Pore Domain / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014764:Viral Proteins / Q000737:chemistry*; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry*; D000074010:Bone Marrow Stromal Antigen 2; D000086082:Viroporin Proteins
chemical_list: D015703:Antigens, CD; D015704:CD4 Antigens; D058851:GPI-Linked Proteins; D054298:Human Immunodeficiency Virus Proteins; D009419:Nerve Tissue Proteins; D009856:Oncogene Proteins, Viral; D024683:Potassium Channels, Tandem Pore Domain; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C054859:oncogene protein E5, Human papillomavirus type 16; D000086082:Viroporin Proteins; C088369:p7 protein, Hepatitis C virus; C514859:vpu protein, Human immunodeficiency virus 1; C420132:potassium channel subfamily K member 3
keywords: E5 of HPV16; Viral channel proteins; Viral-host protein–protein interaction; Vpu of HIV-1; p7 of HCV