title: Perspectives on clinical magnetic particle imaging.
abstract: After realizing the worlds' first preclinical magnetic particle imaging (MPI) demonstrator, Philips is now realizing the worlds' first whole-body clinical prototype to prove the feasibility of MPI for clinical imaging. After a brief introduction of the basic MPI imaging process, this contribution presents an overview on the determining factors for key properties, i.e., spatial resolution, acquisition speed, sensitivity, and quantitativeness, and how these properties are influenced by scaling up from preclinical to clinical instrumentation. Furthermore, it is discussed how this scale up affects the physiological compatibility of the method as well as hardware parameters such as power requirements for drive field generation, selection and focus field generation, and the design of the receive chain of the MPI device.
authors.forename: Jörn
authors.initials: J
authors.lastname: Borgert
authors.forename: Joachim D
authors.initials: JD
authors.lastname: Schmidt
authors.forename: Ingo
authors.initials: I
authors.lastname: Schmale
authors.forename: Claas
authors.initials: C
authors.lastname: Bontus
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gleich
authors.forename: Bernd
authors.initials: B
authors.lastname: David
authors.forename: Jürgen
authors.initials: J
authors.lastname: Weizenecker
authors.forename: Jonas
authors.initials: J
authors.lastname: Jockram
authors.forename: Christian
authors.initials: C
authors.lastname: Lauruschkat
authors.forename: Oliver
authors.initials: O
authors.lastname: Mende
authors.forename: Mathias
authors.initials: M
authors.lastname: Heinrich
authors.forename: Aleksi
authors.initials: A
authors.lastname: Halkola
authors.forename: Jörn
authors.initials: J
authors.lastname: Bergmann
authors.forename: Oliver
authors.initials: O
authors.lastname: Woywode
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rahmer
mesh_terms: D003287:Contrast Media; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D058185:Magnetite Nanoparticles; D057054:Molecular Imaging / Q000295:instrumentation* / Q000379:methods*
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles