title: The EULAR Sjogren's syndrome patient reported index as an independent determinant of health-related quality of life in primary Sjogren's syndrome patients: in comparison with non-Sjogren's sicca patients.
abstract: OBJECTIVE
  To investigate the significant determinants of health-related quality of life (HRQOL) and the association of the EULAR Sjögren's syndrome patient reported index (ESSPRI) with clinical parameters including HRQOL in Korean patients with primary Sjögren's syndrome (pSS) compared with non-SS sicca patients.
  
  
  METHODS
  We prospectively analysed 104 pSS and 42 non-SS sicca patients. Clinical data including Short Form 36 (SF-36) scores, self-assessments for symptoms and ESSPRI were cross-sectionally collected.
  
  
  RESULTS
  Although most self-assessments and HRQOL statuses were comparable, different association patterns between HRQOL and symptoms were observed in pSS and non-SS sicca patients. pSS patients with low HRQOL had significantly higher ESSPRI scores [P = 7.6 × 10(-6) for physical component summary (PCS) subgroups and P = 0.0015 for mental component summary (MCS) subgroups] and ESSPRI scores showed a significant association with all SF-36 scales in pSS patients (all P ≤ 0.0020). Moreover, in multivariate linear regression analyses, ESSPRI (P = 0.035) and depression (P = 4.1 × 10(-14)) were significantly correlated with the PCS and the MCS, respectively. However, in the non-SS sicca group, xerostomia inventory (XI) scores were higher in the low PCS subgroup (P = 0.031) and this correlated with five SF-36 scales (all P ≤ 0.046). XI scores (P = 0.0039) and anxiety (P = 7.9 × 10(-10)) were the main determinants of the PCS and MCS, respectively.
  
  
  CONCLUSIONS
  HRQOL levels were differentially associated with clinical facets in pSS and non-SS sicca patients, although the groups had similar clinical symptoms and HRQOL reduction. Because depression and ESSPRI are major determinants of HRQOL in Korean pSS patients, ESSPRI is suggested to be disease-specific for pSS.
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, 166, Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea. yn35@snu.ac.kr.
authors.forename: Hyon Joung
authors.initials: HJ
authors.lastname: Cho
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Yoo
authors.forename: Chan Young
authors.initials: CY
authors.lastname: Yun
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Kang
authors.forename: Hyo-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Hyon
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
authors.forename: Yun Jong
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000704:Analysis of Variance; D001007:Anxiety / Q000209:etiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D015352:Dry Eye Syndromes / Q000523:psychology; D005221:Fatigue / Q000209:etiology; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008875:Middle Aged; D063806:Myalgia / Q000209:etiology; D011446:Prospective Studies; D011788:Quality of Life; D056910:Republic of Korea; D012859:Sjogren's Syndrome / Q000523:psychology*; D014987:Xerostomia / Q000523:psychology
keywords: EULAR Sjögren’s syndrome patient reported index; depression; health-related quality of life; primary Sjögren’s syndrome