title: Non-canonical p53 signaling to promote invasion.
abstract: It has been known for a number of years that mutated "inactive" p53 proteins still capable of binding to DNA per se, can bind to DNA sequences that are non-canonical for p53, with for example, a resultant increase in the transcription and expression of growth factor receptors such as ERBB1, (1)(,) (2) i.e., mutation of p53 not merely results in "no p53 function" but in fact results in "oncogenic p53 function". And in agreement with this postulate transduction of p53 null cells with mutant p53 can cause transformation. (3) In prior studies the authors of the present manuscript had demonstrated that expression of p53 (R175H) and ERBB1 could transform immortalized primary esophageal cells, in parallel with increased migratory ability. (4) These present studies have defined why those transformed cells became invasive: increased c-Met activity. (5.)
authors.affiliation: Department of Neurosurgery; Massey Cancer Center; Virginia Commonwealth University; Richmond, VA USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Dent
mesh_terms: D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness / Q000473:pathology*; D010766:Phosphorylation; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D019859:Proto-Oncogene Proteins c-met
keywords: c-Met; esophageal cancer; p53 mutation; tumor invasion
references.citation: Genes Dev. 2007 Nov 1;21(21):2788-803
references.pmid: 17974918
references.citation: J Biol Chem. 2005 Apr 15;280(15):14597-604
references.pmid: 15708852
references.citation: Neoplasia. 2012 Nov;14(11):1015-22
references.pmid: 23226095
references.citation: Oncogene. 2002 Jan 10;21(2):176-89
references.pmid: 11803461
references.citation: Cell. 2004 Dec 17;119(6):847-60
references.pmid: 15607980
references.citation: Hepatology. 2004 Oct;40(4):961-71
references.pmid: 15382121
references.citation: Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S99-114
references.pmid: 17259563
references.citation: Cell Death Differ. 2013 Jul;20(7):855-7
references.pmid: 23749181
references.citation: Cancer Biol Ther. 2013 Sep;14(9):853-9
references.pmid: 23792586