title: Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
abstract: Sirtuins (SIRT1-SIRT7), the mammalian homologs of the silent information regulator 2 (Sir2) in Saccharomyces cerevisiae, have been a major focus of study in the scientific community this past decade because of their emerging role in cancer biology and other age-related diseases. Emerging functions for this unique family of enzymes include roles in genomic stability, angiogenesis, metabolism, and anoikis. Here, we review recent developments on the role of sirtuins in cancer with a particular focus on SIRT3 and its role in the hallmarks of cancer and as a potential drug target for cancer treatment.
authors.affiliation: Division of Oral Biology, Oral Basic and Clinical Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Turki Y
authors.initials: TY
authors.lastname: Alhazzazi
authors.forename: Pachiyappan
authors.initials: P
authors.lastname: Kamarajan
authors.forename: Eric
authors.initials: E
authors.lastname: Verdin
authors.forename: Yvonne L
authors.initials: YL
authors.lastname: Kapila
keywords: SIRT3; anoikis; cancer; sirtuin-3; sirtuins; tumor promoter; tumor suppressor
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