title: Topological graph kernel on multiple thresholded functional connectivity networks for mild cognitive impairment classification.
abstract: Recently, brain connectivity networks have been used for classification of Alzheimer's disease and mild cognitive impairment (MCI) from normal controls (NC). In typical connectivity-networks-based classification approaches, local measures of connectivity networks are first extracted from each region-of-interest as network features, which are then concatenated into a vector for subsequent feature selection and classification. However, some useful structural information of network, especially global topological information, may be lost in this type of approaches. To address this issue, in this article, we propose a connectivity-networks-based classification framework to identify accurately the MCI patients from NC. The core of the proposed method involves the use of a new graph-kernel-based approach to measure directly the topological similarity between connectivity networks. We evaluate our method on functional connectivity networks of 12 MCI and 25 NC subjects. The experimental results show that our proposed method achieves a classification accuracy of 91.9%, a sensitivity of 100.0%, a balanced accuracy of 94.0%, and an area under receiver operating characteristic curve of 0.94, demonstrating a great potential in MCI classification, based on connectivity networks. Further connectivity analysis indicates that the connectivity of the selected brain regions is different between MCI patients and NC, that is, MCI patients show reduced functional connectivity compared with NC, in line with the findings reported in the existing studies.
authors.affiliation: Department of Computer Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China; Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina.
authors.forename: Biao
authors.initials: B
authors.lastname: Jie
authors.forename: Daoqiang
authors.initials: D
authors.lastname: Zhang
authors.forename: Chong-Yaw
authors.initials: CY
authors.lastname: Wee
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D016571:Neural Networks, Computer
keywords: Alzheimer's disease; functional connectivity network; graph kernel; mild cognitive impairment; multiple thresholds
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