title: Electrodiagnostic evaluation of peripheral nervous system changes in patients with multiple sclerosis.
abstract: BACKGROUND
  There is supportive evidence that multiple sclerosis (MS) could potentially affect the peripheral nervous system. We assessed peripheral sensory and motor nerve involvement in patients with MS by a nerve conduction velocity test.
  
  
  METHODS
  We studied 75 patients who had a relapsing-remitting or secondary progressive pattern. We measured amplitude, latency, conduction velocity, Hoffmann reflex (H-Reflex), and F-Waves.
  
  
  RESULTS
  The amplitude of the right tibial, right proneal, left tibial, left proneal, and left median motor nerves was less than the mean for the normal population. Right ulnar sensory conduction in the patients showed an amplitude that was less than that of the normal population; there was no significant change in the amplitude of other sensory nerves. Latencies of the right and left median and right proneal motor nerves and left ulnar sensory nerves were statistically less than that of the normal population. Mean motor conduction velocity and F-wave conduction did not differ significantly from the normal population. H-reflex latencies of the right and left lower limbs were significantly more prolonged than those of the normal population.
  
  
  CONCLUSIONS
  Our results suggest possible peripheral motor nerve abnormalities in MS patients, especially with the amplitude of the motor nerves; however, our results do not demonstrate any significant difference among the nerve conduction velocity parameters of sensory nerves between MS patients and the normal population.
authors.affiliation: Department of Neurology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz 51666-14756, Iran ; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14756, Iran.
authors.forename: Hormoz
authors.initials: H
authors.lastname: Ayromlou
authors.forename: Hadi
authors.initials: H
authors.lastname: Mohammad-Khanli
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yazdchi-Marandi
authors.forename: Reza
authors.initials: R
authors.lastname: Rikhtegar
authors.forename: Sina
authors.initials: S
authors.lastname: Zarrintan
authors.forename: Samad Ej
authors.initials: SE
authors.lastname: Golzari
authors.forename: Kamyar
authors.initials: K
authors.lastname: Ghabili
keywords: demyelination; latency; multiple sclerosis; nerve conduction velocity; peripheral neuropathy
references.citation: Riv Patol Nerv Ment. 1982 Sep-Oct;102(5):201-4
references.pmid: 7156794
references.citation: Clin Neurophysiol. 2008 Aug;119(8):1829-1833
references.pmid: 18495530
references.citation: Acta Neurol Scand. 1995 Apr;91(4):234-8
references.pmid: 7625146
references.citation: J Neurol Sci. 2007 Aug 15;259(1-2):3-6
references.pmid: 17367814
references.citation: Neurology. 2007 May 29;68(22 Suppl 3):S5-12; discussion S43-54
references.pmid: 17548569
references.citation: Neurol Neurochir Pol. 1999 Jan-Feb;33(1):53-62
references.pmid: 10399724
references.citation: Eur J Neurol. 2011 May;18(5):789-91
references.pmid: 20629712
references.citation: Electromyogr Clin Neurophysiol. 2003 Sep;43(6):349-51
references.pmid: 14535047
references.citation: J Neurol Sci. 2007 Aug 15;259(1-2):7-15
references.pmid: 17397873
references.citation: Neurol Neurochir Pol. 2004 Jul-Aug;38(4):257-64
references.pmid: 15383952
references.citation: ISRN Neurol. 2012;2012:491892
references.pmid: 22888452
references.citation: Arch Phys Med Rehabil. 1994 Jul;75(7):778-82
references.pmid: 8024424
references.citation: Muscle Nerve. 1982;5(9S):S157-60
references.pmid: 7169997
references.citation: Muscle Nerve. 1992 Nov;15(11):1265-70
references.pmid: 1488064
references.citation: J Clin Neurophysiol. 2010 Apr;27(2):120-5
references.pmid: 20505376
references.citation: Muscle Nerve. 1982 May-Jun;5(5):411-4
references.pmid: 6289099
references.citation: Ann Neurol. 2001 Jul;50(1):121-7
references.pmid: 11456302
references.citation: Int J Gen Med. 2012;5:99-103
references.pmid: 22319247
references.citation: J Clin Neuromuscul Dis. 2008 Jun;9(4):385-96
references.pmid: 18525422
references.citation: J Med Case Rep. 2011 Oct 27;5:530
references.pmid: 22032472
references.citation: Ann Neurol. 2008 Sep;64(3):247-54
references.pmid: 18570297