title: [Network regulation of renin-angiotensin system on the cardiovascular diseases].
abstract: It is well established that renin-angiotensin system (RAS) is the major regulatory network that maintains blood pressure, fluid and electrolyte balance, and involves the pathogenesis and development of cardiovascular system. Recently, studies on RAS has made remarkable achievements, angiotensin-converting enzyme inhibitors and angiotensin receptor inhibitors has become the first-line drug for clinical treatment of hypertension and other cardiovascular diseases. Recent identification of multiple products degraded from angiotensin I, enzymes and receptors have proved that RAS has become a complex network regulating system. In order to better understand the mechanism of RAS regulation, this article intends to introduce the main members of RAS and its network regulation effects in cardiovascular system from enzyme level, metabolite level, receptor level, and signaling pathway.
authors.affiliation: Department of Pathology and Pathophysiology, Capital Medical University, Beijing 100069, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Wang
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Li
mesh_terms: D000803:Angiotensin I / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000502:physiology; D011945:Receptors, Angiotensin / Q000502:physiology; D012083:Renin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C090830:AT4 receptor; D011945:Receptors, Angiotensin; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; D012083:Renin