title: Single-nucleotide polymorphisms in TrkB and risk for depression: findings from the women's interagency HIV study.
abstract: Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.
authors.affiliation: Departments of *Neuroscience and †Medicine, Georgetown University Medical Center, Washington, DC; ‡Departments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY; §Departments of Medicine, Stroger Hospital and Rush University, Chicago, IL; ‖Departments of Neurology and Pathology, SUNY Downstate Medical Center, Brooklyn, NY; ¶Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; #Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Departments of **Neurology; ††Biostatistics, Bioinformatics, and Biomathematics; ‡‡Psychiatry, Georgetown University Medical Center, Washington, DC; and §§Collaborative for Research on Outcomes and Metrics, Department of Neurology, Georgetown University Medical Center, Washington, DC.
authors.forename: Valeriya
authors.initials: V
authors.lastname: Avdoshina
authors.forename: Italo
authors.initials: I
authors.lastname: Mocchetti
authors.forename: Chenglong
authors.initials: C
authors.lastname: Liu
authors.forename: Mary A
authors.initials: MA
authors.lastname: Young
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.forename: Howard
authors.initials: H
authors.lastname: Crystal
authors.forename: Celeste L
authors.initials: CL
authors.lastname: Pearce
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Golub
authors.forename: Rochelle E
authors.initials: RE
authors.lastname: Tractenberg
mesh_terms: D001741:Black or African American / Q000235:genetics; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020813:Receptor, trkB / Q000235:genetics* / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D044465:White People / Q000235:genetics; D016387:Women's Health
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; C579455:BDNF protein, human; D020813:Receptor, trkB
references.citation: Am J Psychiatry. 2002 May;159(5):789-96
references.pmid: 11986133
references.citation: Eur J Neurosci. 2004 Dec;20(11):2857-64
references.pmid: 15579139
references.citation: CNS Drugs. 2002;16(6):361-72
references.pmid: 12027783
references.citation: Brain Struct Funct. 2008 Sep;213(1-2):93-118
references.pmid: 18704495
references.citation: Psychiatry Res. 2002 Mar 15;109(2):143-8
references.pmid: 11927139
references.citation: Neuron. 2006 Jul 6;51(1):21-8
references.pmid: 16815329
references.citation: Afr J Psychiatry (Johannesbg). 2009 May;12(2):115-28
references.pmid: 19582313
references.citation: Trends Neurosci. 2002 Jun;25(6):295-301
references.pmid: 12086747
references.citation: Nat Neurosci. 2009 Feb;12(2):113-5
references.pmid: 19136973
references.citation: Nat Rev Neurosci. 2003 Apr;4(4):299-309
references.pmid: 12671646
references.citation: J Clin Exp Neuropsychol. 2006 Apr;28(3):420-37
references.pmid: 16618629
references.citation: JAMA. 2001 Mar 21;285(11):1466-74
references.pmid: 11255423
references.citation: Biol Psychiatry. 2001 Aug 15;50(4):260-5
references.pmid: 11522260
references.citation: J Hum Genet. 2011 Nov;56(11):806-9
references.pmid: 21938001
references.citation: Clin Diagn Lab Immunol. 2005 Sep;12(9):1013-9
references.pmid: 16148165
references.citation: J Neurosci. 2005 Jun 1;25(22):5455-63
references.pmid: 15930396
references.citation: Biol Psychiatry. 2003 Jul 1;54(1):70-5
references.pmid: 12842310
references.citation: Nature. 2008 Oct 16;455(7215):894-902
references.pmid: 18923511
references.citation: J Psychiatr Res. 2007 Dec;41(12):979-90
references.pmid: 17239400
references.citation: Int Clin Psychopharmacol. 2011 Jan;26(1):1-10
references.pmid: 21188787
references.citation: J Neurosci. 2012 Jul 11;32(28):9477-84
references.pmid: 22787033
references.citation: Nat Genet. 1999 Jul;22(3):231-8
references.pmid: 10391209
references.citation: PLoS One. 2012;7(6):e39301
references.pmid: 22802923
references.citation: AIDS Behav. 2011 Nov;15(8):1834-43
references.pmid: 21748277
references.citation: AIDS Read. 2006 Nov;16(11):615-6, 621-4, 626, 629-32
references.pmid: 17152649
references.citation: Cell. 2009 Jan 23;136(2):215-33
references.pmid: 19167326
references.citation: Trends Neurosci. 2012 Jan;35(1):47-56
references.pmid: 22217452
references.citation: AIDS. 2011 May 15;25(8):1126-8
references.pmid: 21422985
references.citation: Psychosom Med. 1998 Jan-Feb;60(1):11-6
references.pmid: 9492233