title: Serum brain-derived neurotrophic factor levels in different neurological diseases.
abstract: Consistent evidence indicates the involvement of the brain-derived neurotrophic factor (BDNF) in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In the present study, we compared serum BDNF in 624 subjects: 266 patients affected by AD, 28 by frontotemporal dementia (FTD), 40 by Lewy body dementia (LBD), 91 by vascular dementia (VAD), 30 by PD, and 169 controls. Our results evidenced lower BDNF serum levels in AD, FTD, LBD, and VAD patients (P < 0.001) and a higher BDNF concentration in patients affected by PD (P = 0.045). Analyses of effects of pharmacological treatments suggested significantly higher BDNF serum levels in patients taking mood stabilizers/antiepileptics (P = 0.009) and L-DOPA (P < 0.001) and significant reductions in patients taking benzodiazepines (P = 0.020). In conclusion, our results support the role of BDNF alterations in neurodegenerative mechanisms common to different forms of neurological disorders and underline the importance of including drug treatment in the analyses to avoid confounding effects.
authors.affiliation: Department of Neuroscience, AFaR-Fatebenefratelli Hospital, Isola Tiberina 39, 00186 Rome, Italy.
authors.forename: Mariacarla
authors.initials: M
authors.lastname: Ventriglia
authors.forename: Roberta
authors.initials: R
authors.lastname: Zanardini
authors.forename: Cristina
authors.initials: C
authors.lastname: Bonomini
authors.forename: Orazio
authors.initials: O
authors.lastname: Zanetti
authors.forename: Daniele
authors.initials: D
authors.lastname: Volpe
authors.forename: Patrizio
authors.initials: P
authors.lastname: Pasqualetti
authors.forename: Massimo
authors.initials: M
authors.lastname: Gennarelli
authors.forename: Luisella
authors.initials: L
authors.lastname: Bocchio-Chiavetto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy; D000927:Anticonvulsants / Q000008:administration & dosage; D001569:Benzodiazepines / Q000008:administration & dosage; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D015140:Dementia, Vascular / Q000097:blood; D005260:Female; D057180:Frontotemporal Dementia / Q000097:blood; D006801:Humans; D020961:Lewy Body Disease / Q000097:blood; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants; D019208:Brain-Derived Neurotrophic Factor; D001569:Benzodiazepines
references.citation: J Psychiatr Res. 2010 Jun;44(8):506-10
references.pmid: 19954800
references.citation: J Neurosci. 2009 Dec 9;29(49):15472-8
references.pmid: 20007471
references.citation: J Neurochem. 2004 Mar;88(5):1059-67
references.pmid: 15009662
references.citation: Dev Neurobiol. 2010 Apr;70(5):289-97
references.pmid: 20186711
references.citation: Ther Drug Monit. 2010 Feb;32(1):19-29
references.pmid: 19901867
references.citation: Dement Geriatr Cogn Disord. 2011;31(1):31-6
references.pmid: 21135555
references.citation: Ann N Y Acad Sci. 2008 Nov;1144:97-112
references.pmid: 19076369
references.citation: Pharmacol Ther. 2012 Apr;134(1):116-24
references.pmid: 22281237
references.citation: J Alzheimers Dis. 2009;16(3):649-56
references.pmid: 19276559
references.citation: Mol Cell Neurosci. 2006 Jan;31(1):70-84
references.pmid: 16214365
references.citation: Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):144-8
references.pmid: 20975515
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: J Neurochem. 2005 Jun;93(6):1412-21
references.pmid: 15935057
references.citation: Thromb Haemost. 2002 Apr;87(4):728-34
references.pmid: 12008958
references.citation: Biol Psychiatry. 2001 Aug 15;50(4):260-5
references.pmid: 11522260
references.citation: Nat Rev Drug Discov. 2011 Mar;10(3):209-19
references.pmid: 21358740
references.citation: World J Biol Psychiatry. 2010 Sep;11(6):763-73
references.pmid: 20334574
references.citation: Brain Res. 2006 Jun 20;1095(1):207-10
references.pmid: 16725125
references.citation: Brain Res. 2004 Jul 30;1016(1):72-8
references.pmid: 15234254
references.citation: Prog Neurobiol. 2001 Jan;63(1):71-124
references.pmid: 11040419
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):17-22
references.pmid: 21803112
references.citation: J Psychiatr Res. 2009 Jan;43(3):247-54
references.pmid: 18511076
references.citation: Neuroreport. 2004 Mar 22;15(4):717-20
references.pmid: 15094483
references.citation: Neurology. 1967 May;17(5):427-42
references.pmid: 6067254
references.citation: Biol Psychiatry. 2003 Jul 1;54(1):70-5
references.pmid: 12842310
references.citation: Thromb Haemost. 2006 Jul;96(1):102-3
references.pmid: 16807663
references.citation: Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:S71-7
references.pmid: 22986448
references.citation: Nat Rev Neurol. 2009 Jun;5(6):311-22
references.pmid: 19498435
references.citation: J Clin Psychopharmacol. 2010 Dec;30(6):751-3
references.pmid: 21057246
references.citation: Neuroscience. 1999;88(4):1015-32
references.pmid: 10336117
references.citation: Eur Arch Psychiatry Clin Neurosci. 2006 Oct;256(7):402-6
references.pmid: 16783499
references.citation: Neurology. 1998 Dec;51(6):1546-54
references.pmid: 9855500
references.citation: J Geriatr Psychiatry Neurol. 2008 Sep;21(3):166-70
references.pmid: 18503034
references.citation: Biol Psychiatry. 2008 Sep 15;64(6):527-32
references.pmid: 18571629
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):158-9
references.pmid: 19013208
references.citation: Psychiatry Investig. 2009 Dec;6(4):299-305
references.pmid: 20140129
references.citation: Neurosci Lett. 2000 Jan 21;279(1):33-6
references.pmid: 10670781
references.citation: Amino Acids. 2005 Mar;28(2):157-64
references.pmid: 15750845
references.citation: Neurology. 1993 Feb;43(2):250-60
references.pmid: 8094895
references.citation: World J Biol Psychiatry. 2010 Sep;11(6):774-80
references.pmid: 20491609
references.citation: Brain Res Mol Brain Res. 1996 Mar;36(2):280-6
references.pmid: 8965648
references.citation: Neuropharmacology. 1998 Dec;37(12):1553-61
references.pmid: 9886678
references.citation: Scand J Immunol. 2003 May;57(5):493-7
references.pmid: 12753507
references.citation: Eur J Neurosci. 2005 Sep;22(5):1081-9
references.pmid: 16176349
references.citation: Biol Psychiatry. 2007 Sep 1;62(5):530-5
references.pmid: 17560556
references.citation: Biomark Med. 2010 Dec;4(6):871-87
references.pmid: 21133708
references.citation: Int J Neuropsychopharmacol. 2010 Feb;13(1):103-8
references.pmid: 19835669
references.citation: J Psychiatr Res. 2007 Aug;41(5):387-94
references.pmid: 16554070
references.citation: FEBS Lett. 2000 Mar 24;470(2):113-7
references.pmid: 10734218
references.citation: J Neurol. 2010 Apr;257(4):540-5
references.pmid: 19847468
references.citation: Neurology. 2005 Dec 27;65(12):1863-72
references.pmid: 16237129
references.citation: Acta Neuropathol. 2001 Mar;101(3):229-38
references.pmid: 11307622
references.citation: Curr Opin Neurobiol. 2007 Jun;17(3):325-30
references.pmid: 17419049
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: J Neurosci. 2006 Jul 5;26(27):7189-200
references.pmid: 16822976
references.citation: Biochem Biophys Res Commun. 2004 May 21;318(1):113-8
references.pmid: 15110760
references.citation: Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837
references.pmid: 17542011
references.citation: Acta Neuropathol. 2005 Feb;109(2):141-50
references.pmid: 15619128
references.citation: Neuromolecular Med. 2011 Dec;13(4):217-22
references.pmid: 21898045