title: Calcifying epithelial odontogenic tumour with clear langerhans cells: a novel variant, report of a case and review of the literature.
abstract: Clear cell calcifying epithelial odontogenic tumour (CCEOT) is a rare variant of calcifying epithelial odontogenic tumor (CEOT). While it is not surprising to find clear cells in odontogenic lesions, the exact nature of the clear cells in CCEOT has not been elucidated. Herein, we report a case of peripheral CCEOT of anterior mandible in a 37 year old black female. Histologically, the tumour consisted of cords and small nests of clear cells surrounded by dense deposits of amyloid and basophilic calcifications. The cells possessed abundant clear cytoplasm and eccentrically located indented nuclei. Admixed with the clear cells were eosinophilic cuboidal to polyhedral cells. The clear cells were PAS negative and immunoreactive for S100 protein, CD1a and Langerin. The clear cells were negative for MNF-116, SMA, Desmin and CK-19. It is therefore recommended to recognize two variants of CCEOT, namely, CEOT with clear cell change and CEOT with clear Langerhans cells (LC). We further suggest that the contradictory term "non-calcifying variant of calcifying epithelial odontogenic tumour with LC" to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.
authors.affiliation: Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa, amir.afrogheh@nhls.ac.za.
authors.forename: Amir
authors.initials: A
authors.lastname: Afrogheh
authors.forename: Johann
authors.initials: J
authors.lastname: Schneider
authors.forename: Noor
authors.initials: N
authors.lastname: Mohamed
authors.forename: Jos
authors.initials: J
authors.lastname: Hille
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
references.citation: Head Neck. 1994 May-Jun;16(3):272-7
references.pmid: 8026959
references.citation: Allerg Immunol (Leipz). 1979;25(2):116-31
references.pmid: 159606
references.citation: Ann Surg Oncol. 2007 Oct;14(10):2854-60
references.pmid: 17593331
references.citation: Cancer. 1989 Feb 1;63(3):496-503
references.pmid: 2912528
references.citation: J Am Dent Assoc. 1967 May;74(6):1231-40
references.pmid: 5228560
references.citation: Oral Oncol. 2003 Feb;39(2):190-4
references.pmid: 12509974
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jul;112(1):e26-34
references.pmid: 21669357
references.citation: Cancer. 1986 Jan 1;57(1):100-5
references.pmid: 3940609
references.citation: J Oral Pathol Med. 1990 Oct;19(9):430-4
references.pmid: 2269939
references.citation: Nature. 1981 Nov 5;294(5836):85-7
references.pmid: 7290214
references.citation: J Oral Pathol Med. 2007 Aug;36(7):436-9
references.pmid: 17617838
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 May;83(5):577-83
references.pmid: 9159818
references.citation: Cancer. 1958 Jul-Aug;11(4):838-43
references.pmid: 13561253
references.citation: Cancer Lett. 2007 Sep 18;255(1):145-52
references.pmid: 17574329
references.citation: Oral Oncol. 2000 Jan;36(1):17-26
references.pmid: 10889914
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Mar;95(3):332-9
references.pmid: 12627106
references.citation: Virchows Arch A Pathol Anat Histopathol. 1985;407(2):177-89
references.pmid: 3927583
references.citation: J Oral Pathol Med. 1993 Sep;22(8):378-83
references.pmid: 8283404
references.citation: Am J Dermatopathol. 1987 Dec;9(6):465-73
references.pmid: 2965525
references.citation: Am J Surg Pathol. 2013 Jul;37(7):1001-5
references.pmid: 23715163
references.citation: J Oral Maxillofac Surg. 2009 Jan;67(1):207-11
references.pmid: 19070770
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):407-11
references.pmid: 19157927
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Jan;81(1):79-83
references.pmid: 8850489
references.citation: Head Neck Surg. 1985 Nov-Dec;8(2):115-23
references.pmid: 4077550
references.citation: Clin Cancer Res. 2006 Jul 1;12(13):3902-7
references.pmid: 16818685
references.citation: Histopathology. 1984 Mar;8(2):229-44
references.pmid: 6233213