title: Vitamin B(12) metabolism during pregnancy and in embryonic mouse models.
abstract: Vitamin B(12) (cobalamin, Cbl) is required for cellular metabolism. It is an essential coenzyme in mammals for two reactions: the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of methylmalonyl-CoA to succinyl-CoA by the enzyme methylmalonyl-CoA mutase. Symptoms of Cbl deficiency are hematological, neurological and cognitive, including megaloblastic anaemia, tingling and numbness of the extremities, gait abnormalities, visual disturbances, memory loss and dementia. During pregnancy Cbl is essential, presumably because of its role in DNA synthesis and methionine synthesis; however, there are conflicting studies regarding an association between early pregnancy loss and Cbl deficiency. We here review the literature about the requirement for Cbl during pregnancy, and summarized what is known of the expression pattern and function of genes required for Cbl metabolism in embryonic mouse models.
authors.affiliation: Department of Human Genetics, McGill University, 1205 Avenue Docteur Penfield, N5/13,Montreal, Quebec, Canada H3A 1B1. loydie.majewska@mcgill.ca.
authors.forename: Maira A
authors.initials: MA
authors.lastname: Moreno-Garcia
authors.forename: David S
authors.initials: DS
authors.lastname: Rosenblatt
authors.forename: Loydie A
authors.initials: LA
authors.lastname: Jerome-Majewska
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D008715:Methionine / Q000096:biosynthesis; D008765:Methylmalonyl-CoA Mutase / Q000378:metabolism; D051379:Mice; D011247:Pregnancy; D014805:Vitamin B 12 / Q000097:blood* / Q000493:pharmacokinetics*; D014806:Vitamin B 12 Deficiency / Q000097:blood
chemical_list: D000214:Acyl Coenzyme A; D006710:Homocysteine; C015357:methylmalonyl-coenzyme A; D008715:Methionine; C012046:succinyl-coenzyme A; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D008765:Methylmalonyl-CoA Mutase; D014805:Vitamin B 12
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