title: A case of podocytic infolding glomerulopathy with focal segmental glomerulosclerosis.
abstract: Podocytic infolding glomerulopathy (PIG) has been proposed as a new disease entity. A 14-year-old girl underwent renal biopsy at our institution because of a chance finding of proteinuria. Light microscopic findings revealed a minor glomerular abnormality, but under a higher magnification, after periodic acid methenamine silver staining, a bubbling appearance in the glomerular basement membrane (GBM) was observed. An electron microscopic examination revealed microspheres in the GBM, which were sparse but global. The patient was diagnosed as having PIG. After 3 years, her urinary protein had increased and a second biopsy was performed, showing focal segmental glomerulosclerosis in addition to a lesser degree of podocytic infolding than at the first biopsy. This is the first report of a case complicated by a different type of glomerulonephritis after being diagnosed as PIG. A few cases of PIG are complicated by focal segmental glomerulosclerosis, suggesting several mechanisms for the disorder.
authors.affiliation: Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iguchi
authors.forename: Ayako
authors.initials: A
authors.lastname: Sohma
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ito
authors.forename: Takako
authors.initials: T
authors.lastname: Saeki
authors.forename: Yumi
authors.initials: Y
authors.lastname: Ito
authors.forename: Naohumi
authors.initials: N
authors.lastname: Imai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osawa
authors.forename: Ichiei
authors.initials: I
authors.lastname: Narita
keywords: Focal segmental glomerulosclerosis; Microspheres; Podocyte; Podocytic infolding glomerulopathy
references.citation: Virchows Arch A Pathol Anat Histopathol. 1992;420(5):447-51
references.pmid: 1595195
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):450-4
references.pmid: 18839060
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):509-12
references.pmid: 18979062
references.citation: Virchows Arch A Pathol Anat Histopathol. 1991;419(4):267-72
references.pmid: 1949609
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):504-8
references.pmid: 19002748
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):421-31
references.pmid: 19012046
references.citation: Kidney Int. 1986 Sep;30(3):399-410
references.pmid: 3537447
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):494-500
references.pmid: 18974926
references.citation: Clin Exp Nephrol. 2008 Dec;12(6):501-3
references.pmid: 19012047
references.citation: J Pathol. 1982 Feb;136(2):133-47
references.pmid: 7199568