title: Patients' motives for consenting or refusing to participate in a clinical trial in organ transplantation.
abstract: BACKGROUND
  The goal of this health-psychology study was to investigate the range of motives that make someone consent or refuse participation in a clinical transplant trial.
  
  
  METHODS
  The study involved (i) preparatory interviews with five transplant patients who took part in clinical trials and five persons from the general public; (ii) we created a questionnaire with scaled responses; (iii) we selected 468 patients, divided into two groups: patients waiting for a transplant and patients who already had a transplant; (iv) we obtained patient consents, sent out the questionnaire, and recorded responses; (v) data were analysed using descriptive statistics, exploratory factorial analyses, correlations and regressions.
  
  
  RESULTS
  Two hundred and ten patients answered the questionnaire. Motives were classified into the following: (i) Motives to consent participating in a clinical trial (pride in participating, hope for better quality of life, sufficient and clear information, discussion with others participating in a trial, altruism); or (ii) Motives to refuse participating (no information on medical teams, lack of explanation, fear of additional expenses, being considered a "guinea pig").
  
  
  CONCLUSIONS
  This study contributes to our understanding of the motivations of patients who accepted or refused participation in a clinical transplantation trial.
authors.affiliation: Department of Psychology, University Toulouse II le Mirail, Toulouse, Midi Pyrénées, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Guedj
authors.forename: Sandrine
authors.initials: S
authors.lastname: Ballester
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.forename: Vincent
authors.initials: V
authors.lastname: Donckier
authors.forename: Michel
authors.initials: M
authors.lastname: Goldman
authors.forename: Anne
authors.initials: A
authors.lastname: Cambon-Thomsen
mesh_terms: D000328:Adult; D000368:Aged; D000533:Altruism; D001294:Attitude to Health; D002986:Clinical Trials as Topic / Q000523:psychology*; D003142:Communication; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007258:Informed Consent / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009042:Motivation; D016377:Organ Transplantation; D010358:Patient Participation / Q000523:psychology*; D045808:Refusal to Participate / Q000523:psychology*; D012107:Research Design; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: clinical trial; health psychology; motivation; patient's view; transplantation