title: HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
abstract: Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T cells classically associated with the detection of missing self through loss of their respective MHC ligand. Some KIR specificities for allelic classical class I MHC (MHC-I) have been described, whereas other KIR receptor-ligand relationships, including those associated with nonclassical MHC-I, have yet to be clearly defined. We report in this article that KIR3DL2 and KIR2DS4 and the nonclassical Ag HLA-F, expressed as a free form devoid of peptide, physically and functionally interact. These interactions extend to include classical MHC-I open conformers as ligands, defining new relationships between KIR receptors and MHC-I. The data collectively suggest a broader, previously unrecognized interaction between MHC-I open conformers--including prototypical HLA-F--and KIR receptors, acting in an immunoregulatory capacity centered on the inflammatory response.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
authors.forename: Jodie P
authors.initials: JP
authors.lastname: Goodridge
authors.forename: Aura
authors.initials: A
authors.lastname: Burian
authors.forename: Ni
authors.initials: N
authors.lastname: Lee
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Geraghty
mesh_terms: D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D015870:Gene Expression; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism*; D008024:Ligands; D011485:Protein Binding / Q000276:immunology; D055503:Protein Multimerization; D011971:Receptors, Immunologic / Q000378:metabolism*; D054347:Receptors, KIR3DL2 / Q000378:metabolism; D055607:Receptors, Natural Killer Cell / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D020349:Surface Plasmon Resonance
chemical_list: C062341:HLA-F antigens; D015395:Histocompatibility Antigens Class I; C515084:KIR3DL2 protein, human; D008024:Ligands; D011971:Receptors, Immunologic; D054347:Receptors, KIR3DL2; D055607:Receptors, Natural Killer Cell; D011994:Recombinant Proteins
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