title: Towards elimination of the dark-rim artifact in first-pass myocardial perfusion MRI: removing Gibbs ringing effects using optimized radial imaging.
abstract: OBJECTIVE
  Subendocardial dark-rim artifacts (DRAs) remain a major concern in first-pass perfusion (FPP) myocardial MRI and may lower the diagnostic accuracy for detection of ischemia. A major source of DRAs is the "Gibbs ringing" effect. We propose an optimized radial acquisition strategy aimed at eliminating ringing-induced DRAs in FPP.
  
  
  METHODS
  By studying the underlying point spread function (PSF), we show that optimized radial sampling with a simple reconstruction method can eliminate the oscillations in the PSF that cause ringing artifacts. We conducted realistic MRI phantom experiments and in vivo studies (n = 12 healthy humans) to evaluate the artifact behavior of the proposed imaging scheme in comparison to a conventional Cartesian imaging protocol.
  
  
  RESULTS
  Simulations and phantom experiments verified our theoretical expectations. The in vivo studies showed that optimized radial imaging is capable of significantly reducing DRAs in the early myocardial enhancement phase (during which the ringing effect is most prominent and may obscure perfusion defects) while providing similar resolution and image quality compared with conventional Cartesian imaging.
  
  
  CONCLUSIONS
  The developed technical framework and results demonstrate that, in comparison to conventional Cartesian techniques, optimized radial imaging with the proposed optimizations significantly reduces the prevalence and spatial extent of DRAs in FPP imaging.
authors.affiliation: Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Behzad
authors.initials: B
authors.lastname: Sharif
authors.forename: Rohan
authors.initials: R
authors.lastname: Dharmakumar
authors.forename: Troy
authors.initials: T
authors.lastname: LaBounty
authors.forename: Reza
authors.initials: R
authors.lastname: Arsanjani
authors.forename: Chrisandra
authors.initials: C
authors.lastname: Shufelt
authors.forename: Louise
authors.initials: L
authors.lastname: Thomson
authors.forename: C Noel Bairey
authors.initials: CN
authors.lastname: Merz
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Berman
authors.forename: Debiao
authors.initials: D
authors.lastname: Li
mesh_terms: D016477:Artifacts; D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017202:Myocardial Ischemia / Q000175:diagnosis; D009206:Myocardium; D009942:Organometallic Compounds / Q000008:administration & dosage; D019047:Phantoms, Imaging; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C112666:gadoversetamide
keywords: Gibbs ringing; dark-rim artifact; first-pass perfusion MRI; myocardial perfusion; radial sampling; subendocardial ischemia
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