title: Factors affecting 18F-FDG uptake by metastatic lymph nodes in gastric cancer.
abstract: OBJECTIVE
  We assessed factors affecting fluorine F 18 fluorodeoxyglucose (F-FDG) uptake of metastatic lymph nodes (LNs) in advanced gastric cancer (AGC) due to low F-FDG uptake of metastatic LNs in gastric cancer.
  
  
  METHODS
  Retrospective analyses were performed on 31 patients with AGCs who underwent preoperative F-FDG positron emission tomography (PET) and subsequent gastrectomy. Metastatic LNs were compared with primary tumors (on a one-to-one basis) with respect to maximum standardized uptake values, glucose transporter type 1 (GLUT-1) expression, proliferation indices (using Ki-67), microvessel density, and lymphatic vessel density.
  
  
  RESULTS
  Maximum standardized uptake values of metastatic LNs were significantly correlated with % GLUT-1 expression (ρ = 0.80, P < 0.0001) and Ki-67 labeling index (ρ = 0.57, P = 0.001) in LNs. These uptake values were also significantly correlated with SUVs (ρ = 0.54; P = 0.002), % GLUT-1 expression (ρ = 0.71, P < 0.0001), and Ki-67 labeling index (ρ = 0.43, P = 0.019) in primary tumors. In multiple regression analysis, only % GLUT-1 expression in primary tumors and metastatic LNs were significant factors in predicting maximum standardized uptake value of metastatic LNs.
  
  
  CONCLUSIONS
  In AGCs, GLUT-1 expression and Ki-67 labeling index are important factors in predicting F-FDG uptake by metastatic LNs.
authors.affiliation: *From the Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; †Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and §Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.†Department of Nuclear Medicine, Hanyang University Guri Hospital, Hanyang University School of Medicine, Guri; and Departments of ‡Pathology and § Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Kim
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Choi
authors.forename: In-Gu
authors.initials: IG
authors.lastname: Do
authors.forename: Sung
authors.initials: S
authors.lastname: Kim
authors.forename: Byung-Tae
authors.initials: BT
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18