title: Mitochondrial iron transport and homeostasis in plants.
abstract: Iron (Fe) is an essential nutrient for plants and although the mechanisms controlling iron uptake from the soil are relatively well understood, comparatively little is known about subcellular trafficking of iron in plant cells. Mitochondria represent a significant iron sink within cells, as iron is required for the proper functioning of respiratory chain protein complexes. Mitochondria are a site of Fe-S cluster synthesis, and possibly heme synthesis as well. Here we review recent insights into the molecular mechanisms controlling mitochondrial iron transport and homeostasis. We focus on the recent identification of a mitochondrial iron uptake transporter in rice and a possible role for metalloreductases in iron uptake by mitochondria. In addition, we highlight recent advances in mitochondrial iron homeostasis with an emphasis on the roles of frataxin and ferritin in iron trafficking and storage within mitochondria.
authors.affiliation: Department of Biological Sciences, University of South Carolina Columbia, SC, USA.
authors.forename: Anshika
authors.initials: A
authors.lastname: Jain
authors.forename: Erin L
authors.initials: EL
authors.lastname: Connolly
keywords: ferritin; frataxin; iron; iron transporter; mitochondria; plant
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