title: Efficacy and tolerability of intravenous pentamidine isethionate for Pneumocystis jiroveci prophylaxis in a pediatric oncology population.
abstract: Cancer therapy routinely requires Pneumocystis jiroveci prophylaxis. In those intolerant of trimethoprim/sulfamethoxazole, aerosolized pentamidine is convenient and effective. Intravenous pentamidine is often substituted in young children but its efficacy remains controversial. In this retrospective study of a large pediatric oncology cohort, we confirm intravenous pentamidine to be effective and well-tolerated as second-line prophylaxis across all ages.
authors.affiliation: From the *Jonathan Jaques Children's Cancer Center, Miller Children's Hospital Long Beach, Long Beach and †Children's Center for Cancer and Blood Disorders, Children's Hospital Los Angeles, Los Angeles, CA.
authors.forename: Etan
authors.initials: E
authors.lastname: Orgel
authors.forename: Teresa
authors.initials: T
authors.lastname: Rushing
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D019072:Antibiotic Prophylaxis / Q000379:methods*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000453:epidemiology; D010372:Pediatrics; D010419:Pentamidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D010419:Pentamidine