title: Preradial myxedema in a euthyroid male: A distinct rarity.
abstract: Localized or pretibial myxedema is one of the signs of Graves disease (along with goiter, exophthalmus, thyroid acropathy, and high circulating levels of long-acting thyroid-stimulating hormone) and usually tends to occur at a later stage of the disease or even after the patient becomes euthyroid post treatment. Very rarely has it been reported in euthyroid patients. We report a euthyroid man presenting with localized myxedema on the extensor surface of his forearm with clinical and histopathological features consistent with pretibial myxedema. He responded partially to topical clobetasol propionate cream and tacrolimus ointment 0.1 percent for about 7 months. To the best of our knowledge, this is the first case of preradial myxedema in a euthyroid patient in the English international dermatological literature.
authors.affiliation: Nirvana Skin Clinic, Vadodara, Gujarat, India.
authors.forename: Shyam
authors.initials: S
authors.lastname: Verma
authors.forename: Franco
authors.initials: F
authors.lastname: Rongioletti
authors.forename: Markus
authors.initials: M
authors.lastname: Braun-Falco
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruzicka
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002990:Clobetasol / Q000627:therapeutic use; D003951:Diagnostic Errors; D005542:Forearm; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007918:Leprosy / Q000175:diagnosis; D008297:Male; D009077:Mucins / Q000032:analysis*; D009230:Myxedema / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D012867:Skin / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D009077:Mucins; D013963:Thyroid Hormones; D002990:Clobetasol; D016559:Tacrolimus