title: Muscle-specific kinase antibody positive myaesthenia gravis and multiple sclerosis co-presentation: a case report and literature review.
abstract: We present the first case of simultaneous muscle-specific kinase antibody positive myaesthenia gravis and relapsing-remitting multiple sclerosis to be reported in the English literature along with the inherent diagnostic and treatment challenges. There may be an association between myaesthenia and central nervous system demyelination. We identified 72 previously published cases of myaesthenia with central nervous system demyelination. Of 19 cases of myaesthenia with relapsing-remitting multiple sclerosis, nine (47%) were acetylcholine receptor antibody negative, but there were no previously published cases with muscle-specific kinase antibody. Further research is required to clarify this association and optimal treatment in such cases.
authors.affiliation: Neurology Department (Clinical Administration 3E), Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia. Electronic address: jsyl2313@uni.sydney.edu.au.
authors.forename: Jessica
authors.initials: J
authors.lastname: Sylvester
authors.forename: Grant
authors.initials: G
authors.lastname: Purdie
authors.forename: Mark
authors.initials: M
authors.lastname: Slee
authors.forename: James X
authors.initials: JX
authors.lastname: Gray
authors.forename: Simon
authors.initials: S
authors.lastname: Burnet
authors.forename: Simon
authors.initials: S
authors.lastname: Koblar
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D009157:Myasthenia Gravis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases
keywords: Demyelination; Multiple sclerosis; Muscle-specific kinase antibody; Myaesthenia gravis