title: Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system.
abstract: Going to the source: The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF3 CO2 K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF3 ] sources.
authors.affiliation: Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D011188:Potassium / Q000378:metabolism*; D014269:Trifluoroacetic Acid / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005461:Fluorine; D003300:Copper; D014269:Trifluoroacetic Acid; D011188:Potassium
keywords: copper; cross-coupling; flow chemistry; fluorine; synthetic methods
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