title: The effect of eradicating Helicobacter pylori on idiopathic central serous chorioretinopathy patients.
abstract: OBJECTIVE
  To evaluate the effect of Helicobacter pylori (H. pylori) eradication on the remission of acute idiopathic central serous chorioretinopathy (ICSCR).
  
  
  METHODS
  A prospective, randomized, placebo-controlled study of 53 participants.
  
  
  METHODS
  Twenty-seven acute ICSCR patients tested positive for H. pylori were given an eradication H. pylori therapy, and another 26 patients with the same diagnosis received matching placebo medication. All participants were tested for the following items: (1) disappearance rate of subretinal fluid (SRF); (2) best-corrected visual acuity (BCVA); and (3) central retinal sensitivity at baseline, 2 weeks, 4 weeks, 8 weeks, and 12 weeks after treatment. The difference between the two groups was analyzed by PASW statistics version 18.0.
  
  
  RESULTS
  At each follow-up, the disappearance rate of SRF in the active treatment group seemed slightly better than in the control group, but no statistically significant differences were observed (P > 0.05 at each follow-up). The BCVA between the two groups also did not demonstrate statistically significant differences (P > 0.05 at each follow-up). Unlike the BCVA and the disappearance rate of SRF, we compared the change in central retinal sensitivity at 12 weeks after treatment; a statistical difference was observed (P = 0.042).
  
  
  CONCLUSIONS
  Our findings suggested that H. pylori eradication does not improve BCVA and the disappearance rate of SRF, but it could improve the central retinal sensitivity in acute ICSCR patients. We recommend that chronic ICSCR patients and more sensitive methods for H. pylori diagnosis should be involved in evaluating the effect of H. pylori eradication.
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China ; Department of Ophthalmology and Visual Science, Yellow River Hospital of Henan University of Science and Technology, Sanmenxia City, Henan, People's Republic of China.
authors.forename: Yalong
authors.initials: Y
authors.lastname: Dang
authors.forename: Yalin
authors.initials: Y
authors.lastname: Mu
authors.forename: Manli
authors.initials: M
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Yaning
authors.initials: Y
authors.lastname: Guo
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
keywords: Helicobacter pylori; acute idiopathic central serous chorioretinopathy; best-corrected visual acuity; central retinal sensitivity; subretinal fluid
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