title: Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.
abstract: Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.
authors.affiliation: College of Pharmacy, Natural Products Research Institute, Seoul National University, San 56-1 Sillim-dong, Gwanak-gu, Seoul 151-741, Republic of Korea.
authors.forename: Min-Ai
authors.initials: MA
authors.lastname: Lee
authors.forename: Won Kyung
authors.initials: WK
authors.lastname: Kim
authors.forename: Hyen Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D060466:Axin Protein / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology; D044947:Flavonolignans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D031239:Lonicera / Q000737:chemistry / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000187:drug effects; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C555451:AXIN1 protein, human; D000972:Antineoplastic Agents, Phytogenic; D060466:Axin Protein; D044947:Flavonolignans; D017705:Lignans; D034741:RNA, Small Interfering; D051153:Wnt Proteins; D051176:beta Catenin; C073621:hydnocarpin
keywords: Anti-proliferation; Axin turnover; Colon cancer cells; Hydnocarpin; Wnt/beta-catenin