title: Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease.
abstract: Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Burçak
authors.initials: B
authors.lastname: Vural
authors.forename: Elçin
authors.initials: E
authors.lastname: Sehitoğlu
authors.forename: Filiz
authors.initials: F
authors.lastname: Cavuş
authors.forename: Nazlı
authors.initials: N
authors.lastname: Yalçınkaya
authors.forename: Hazal
authors.initials: H
authors.lastname: Haytural
authors.forename: Melike
authors.initials: M
authors.lastname: Küçükerden
authors.forename: Canan
authors.initials: C
authors.lastname: Ulusoy
authors.forename: Elif
authors.initials: E
authors.lastname: Uğurel
authors.forename: Selin
authors.initials: S
authors.lastname: Turan
authors.forename: Leyla
authors.initials: L
authors.lastname: Bulut
authors.forename: Recai
authors.initials: R
authors.lastname: Türkoğlu
authors.forename: Erkingül
authors.initials: E
authors.lastname: Shugaiv
authors.forename: Murat
authors.initials: M
authors.lastname: Kürtüncü
authors.forename: Sükrü
authors.initials: S
authors.lastname: Atakan
authors.forename: Ali O
authors.initials: AO
authors.lastname: Güre
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gül
authors.forename: Mefkure
authors.initials: M
authors.lastname: Eraksoy
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akman-Demir
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
mesh_terms: D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000276:immunology*; D024101:Mitochondrial Proteins / Q000097:blood / Q000276:immunology*; D009707:Nucleosomes / Q000276:immunology / Q000378:metabolism; D051381:Rats
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C402222:MTCH1 protein, human; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D009707:Nucleosomes
keywords: Anti-neuronal antibody; Antibody; Autoimmunity; Behçet's disease; Mitochondrial carrier homolog 1; Neuro-Behçet's disease