title: Salivary interleukin-8 levels in children suffering from type 1 diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established.
  
  
  METHODS
  Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study.
  
  
  RESULTS
  The Salivary IL-8 level was statistically significantly (p < 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p > 0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found.
  
  
  CONCLUSIONS
  An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.
authors.affiliation: Clinic of Dental Medicine, Military Medical Academy, Belgrade, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Dakovic
authors.forename: M
authors.initials: M
authors.lastname: Colic
authors.forename: S
authors.initials: S
authors.lastname: Cakic
authors.forename: I
authors.initials: I
authors.lastname: Mileusnic
authors.forename: Z
authors.initials: Z
authors.lastname: Hajdukovic
authors.forename: N
authors.initials: N
authors.lastname: Stamatovic
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D055113:Chronic Periodontitis / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism*; D010512:Periodontal Index; D012463:Saliva / Q000737:chemistry*; D018709:Statistics, Nonparametric
chemical_list: D006442:Glycated Hemoglobin; D016209:Interleukin-8