title: Increased cortical thickness in a frontoparietal network in social anxiety disorder.
abstract: Social anxiety disorder (SAD) is the second leading anxiety disorder. On the functional neurobiological level, specific brain regions involved in the processing of anxiety-laden stimuli and in emotion regulation have been shown to be hyperactive and hyper-responsive in SAD such as amygdala, insula and orbito- and prefrontal cortex. On the level of brain structure, prior studies on anatomical differences in SAD resulted in mixed and partially contradictory findings. Based on previous functional and anatomical models of SAD, this study examined cortical thickness in structural magnetic resonance imaging data of 46 patients with SAD without comorbidities (except for depressed episode in one patient) compared with 46 matched healthy controls in a region of interest-analysis and in whole-brain. In a theory-driven ROI-analysis, cortical thickness was increased in SAD in left insula, right anterior cingulate and right temporal pole. Furthermore, the whole-brain analysis revealed increased thickness in right dorsolateral prefrontal and right parietal cortex. This study detected no regions of decreased cortical thickness or brain volume in SAD. From the perspective of brain networks, these findings are in line with prior functional differences in salience networks and frontoparietal networks associated with executive-controlling and attentional functions.
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zürich, Zurich, Switzerland.
authors.forename: Annette Beatrix
authors.initials: AB
authors.lastname: Brühl
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hänggi
authors.forename: Volker
authors.initials: V
authors.lastname: Baur
authors.forename: Michael
authors.initials: M
authors.lastname: Rufer
authors.forename: Aba
authors.initials: A
authors.lastname: Delsignore
authors.forename: Steffi
authors.initials: S
authors.lastname: Weidt
authors.forename: Lutz
authors.initials: L
authors.lastname: Jäncke
authors.forename: Uwe
authors.initials: U
authors.lastname: Herwig
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology*; D010698:Phobic Disorders / Q000473:pathology*; D055815:Young Adult
keywords: DLPFC; MRI; amygdale; anatomy; anterior cingulate; anxiety disorders; dorsal attention network; emotion processing; hippocampus; insula
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