title: Ebstein's anomaly and Down's syndrome.
abstract: We report on two cases presenting with a rare combination of Ebstein's anomaly and Down's syndrome. The first patient presented with respiratory distress, mild cyanosis and right heart failure immediately after delivery. The symptoms improved with heart failure medication. The patient remained asymptomatic on follow up. The second patient was diagnosed antenatally with marked apical displacement of the tricuspid valve and a very small functional right ventricle compared to the left ventricle. At birth, the patient presented with an extreme form of Ebstein's anomaly with severe cyanosis, marked right heart failure and ductal-dependent pulmonary blood flow. The patient died within days of birth.
authors.affiliation: Dora Nginza Hospital, Port Elizabeth Hospital Complex, Port Elizabeth, South Africa.
authors.forename: Lungile
authors.initials: L
authors.lastname: Pepeta
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Clur
mesh_terms: D003490:Cyanosis / Q000209:etiology; D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D004437:Ebstein Anomaly / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D018618:Echocardiography, Doppler, Color; D004562:Electrocardiography; D017809:Fatal Outcome; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013902:Radiography, Thoracic; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal