title: Protein degradation systems in platelets.
abstract: Protein synthesis and degradation are essential processes that allow cells to survive and adapt to their surrounding milieu. In nucleated cells, the degradation and/or cleavage of proteins is required to eliminate aberrant proteins. Cells also degrade proteins as a mechanism for cell signalling and complex cellular functions. Although the last decade has convincingly shown that platelets synthesise proteins, the roles of protein degradation in these anucleate cytoplasts are less clear. Here we review what is known about protein degradation in platelets placing particular emphasis on the proteasome and the cysteine protease calpain.
authors.affiliation: Andrew Weyrich, MD, Eccles Institute of Human Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, Building 533 Room 4220, Salt Lake City, Utah 84112, USA, Tel: +1 801 5850702, Fax: +1 801 5850701, E-mail: andy.weyrich@u2m2.utah.edu.
authors.forename: B F
authors.initials: BF
authors.lastname: Kraemer
authors.forename: A S
authors.initials: AS
authors.lastname: Weyrich
authors.forename: S
authors.initials: S
authors.lastname: Lindemann
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D057056:Cysteine Proteases / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D059748:Proteolysis; D015398:Signal Transduction
chemical_list: D057056:Cysteine Proteases; D046988:Proteasome Endopeptidase Complex
keywords: Platelets; calpain; proteasome; protein degradation
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