title: [Analysis of correlation between breast cancer molecular subtypes and prognosis of patients receiving breast-conserving therapy].
abstract: OBJECTIVE
  To evaluate the effects of molecular subtypes on the prognosis of breast cancer patients after BCT (breast-conserving therapy).
  
  
  METHODS
  From January 1999 to December 2007, a total of 699 female patients on BCT were analyzed retrospectively. They were grouped according to the results of immunohistochemistry, they were grouped as Luminal A (ER+/PR+/HER2-, Ki-67 < 14%), Luminal B (ER+/PR+/HER2 ± , Ki-67 > 14%), HER2 (ER-/PR-/HER2+) and triple negative breast cancer (TNBC) (ER-/PR-/HER2-).
  
  
  RESULTS
  Among them, the recurrence rate, metastasis rate and survival rate within 5 years after BCT accounted for 6.0%, 6.0% and 91.8% respectively. There were statistical differences in metastasis rate and survival rate among patients with different molecular subtypes (P < 0.001), lymph node status (P < 0.001) and on chemotherapy or not (P < 0.001) on multivariate analysis. Though, on univariate analysis, different molecular subtypes had different risks for local failure (P = 0.022). On multivariate analysis, this difference was not statistically significant (P = 0.081).
  
  
  CONCLUSIONS
  Despite a worse prognosis of TNBC versus other subtypes, BCT is a viable option for selected TNBC patients.
authors.affiliation: First Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.
authors.forename: Wen-wen
authors.initials: WW
authors.lastname: Geng
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Dan-hua
authors.initials: DH
authors.lastname: Li
authors.forename: Xin-rui
authors.initials: XR
authors.lastname: Liang
authors.forename: Xu-chen
authors.initials: XC
authors.lastname: Cao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D012189:Retrospective Studies; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D011960:Receptors, Estrogen