title: Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling.
abstract: A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with a Pd-catalyst only.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute , BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, P.O. Box 173, Lucknow 226031, India, and Academy of Scientific and Innovative Research , New Delhi, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Pandey
authors.forename: Subhendu
authors.initials: S
authors.lastname: Bhowmik
authors.forename: Sanjay
authors.initials: S
authors.lastname: Batra
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper; D007097:Imines / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D007097:Imines; D007546:Isoquinolines; D011720:Pyrazoles; C031280:pyrazole; D010165:Palladium; D003300:Copper