title: Effects of neurolytic celiac plexus block on liver regeneration in rats with partial hepatectomy.
abstract: Liver regeneration is the basic physiological process after partial hepatectomy (PH), and is important for the functional rehabilitation of the liver after acute hepatic injury. This study was designed to explore the effects of neurolytic celiac plexus block (NCPB) on liver regeneration after PH. We established a model of PH in rats, assessing hepatic blood flow, liver function, and serum CRP, TNF-α, IL-1β and IL-6 concentrations of the residuary liver after PH. Additionally, histopathological studies, immunohistochemistry, and western blotting were also performed. Our results indicated that NCPB treatment after PH improved liver regeneration and survival rates, increased hepatic blood flow, reduced hepatocyte damage, decreased the secretion and release of inflammatory cytokines, increased the expression of B cell lymphoma/leukemia-2 (Bcl-2), and decreased the expression of Bcl-2 associated X protein (Bax). Additionally, Western blotting revealed that the expression of NF-κB p65 and c-Jun were decreased in liver after NCPB. In conclusion, the results of our present study indicate that NCPB treatment has a favorable effect on liver regeneration after PH. We suggest that NCPB can be utilized as an effective therapeutic method to help the functional rehabilitation of the liver after acute hepatic injury or liver cancer surgery.
authors.affiliation: Department of Anesthesia, General Hospital of Chengdu Military Command Area, Chengdu, Sichuan Province, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Yan
authors.forename: Jian-Xiang
authors.initials: JX
authors.lastname: Che
authors.forename: Shu-Rong
authors.initials: SR
authors.lastname: Bai
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Qiu
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Fan
authors.initials: F
authors.lastname: Pan
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Sun
authors.forename: Fu-Zhou
authors.initials: FZ
authors.lastname: Tian
authors.forename: Dong-Xuan
authors.initials: DX
authors.lastname: Li
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D002447:Celiac Plexus / Q000187:drug effects*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D006498:Hepatectomy; D018836:Inflammation Mediators / Q000378:metabolism; D008012:Lidocaine / Q000494:pharmacology*; D008099:Liver / Q000098:blood supply / Q000378:metabolism / Q000601:surgery; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow; D051996:Transcription Factor RelA / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D000779:Anesthetics, Local; D016207:Cytokines; D018836:Inflammation Mediators; D019253:Proto-Oncogene Proteins c-bcl-2; D016755:Proto-Oncogene Proteins c-jun; D051996:Transcription Factor RelA; D042442:Vascular Endothelial Growth Factors; D051028:bcl-2-Associated X Protein; D002097:C-Reactive Protein; D008012:Lidocaine
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