title: Clinical trial of tooth desensitization prior to in-office bleaching.
abstract: The aim of this clinical trial was to compare tooth sensitivity during and after bleaching with hydrogen peroxide gel following application of GLUMA Desensitizer PowerGel or placebo. Forty-six subjects with sound maxillary incisors and canines were enrolled. Tooth shades were determined by comparison with a Vitapan Classic Shade guide. GLUMA Desensitizer PowerGel and placebo were randomly applied to the labial surfaces of the left or right anterior teeth for 1 min, which were then rinsed and dried. Then, Opalescence Boost PF 40% gel was applied onto labial enamel for 15 min. Sensitivity scores [recorded on a 10-point visual-analog scale (VAS)] were determined before, at 5, 10, and 15 min during, and 1, 24, 48 h and 1 wk after, the bleaching treatment. Shades were determined postbleaching and after 1 wk. Prebleaching application of GLUMA Desensitizer PowerGel significantly reduced tooth sensitivity during and after bleaching when compared with treatment with placebo. The whitening effects immediately and 1 wk after bleaching were significant when compared with the prebleaching shades. In conclusion, tooth pretreatment with GLUMA Desensitizer PowerGel for 1 min prior to 15 min of in-office bleaching with 40% hydrogen peroxide gel was highly effective in reducing tooth sensitivity during and after bleaching.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Vokkaligara Sangha Dental College and Hospital, Bangalore, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Mehta
authors.forename: Suresh
authors.initials: S
authors.lastname: Venkata
authors.forename: Meena
authors.initials: M
authors.lastname: Naganath
authors.forename: Usha
authors.initials: U
authors.lastname: LingaReddy
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishihata
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Finger
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003743:Dental Enamel / Q000187:drug effects*; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage*; D003807:Dentin Sensitivity / Q000628:therapy*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage*; D008297:Male; D010147:Pain Measurement; D014073:Tooth Bleaching / Q000379:methods*; D058205:Tooth Bleaching Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D057133:Dentin Desensitizing Agents; D058205:Tooth Bleaching Agents; D006861:Hydrogen Peroxide
keywords: GLUMA Desensitizer; clinical trial; desensitization; placebo; tooth whitening