title: A novel noninvasive index for nonalcoholic steatohepatitis: a pilot study.
abstract: OBJECTIVE
  The potential development of a noninvasive marker predicting nonalcoholic steatohepatitis (NASH).
  
  
  METHODS
  Thirty patients with biopsy-proven nonalcoholic fatty liver disease were evaluated by numerous anthropometric, clinical and biochemical parameters.
  
  
  RESULTS
  Serum glutamic oxaloacetic transaminase (SGOT; p = 0.027), log (erythrocyte sedimentation rate) (ESR; p = 0.034) and homocysteine (p = 0.041) were associated with NASH independently from gender, age and body mass index. When combined, the regression model provided R(2) = 0.563 (p = 0.001) and area under the ROC curve = 0.873 ± 0.066 (p < 0.001).
  
  
  CONCLUSIONS
  This noninvasive marker, named HSENSI (acronym of homocysteine, SGOT, ESR, Nonalcoholic Steatohepatitis Index), consists of three low cost, easily measurable parameters and may accurately predict NASH.
authors.affiliation: Department of Medicine, Second Medical Clinic .
authors.forename: Stergios A
authors.initials: SA
authors.lastname: Polyzos
authors.forename: Jannis
authors.initials: J
authors.lastname: Kountouras
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Slavakis
authors.forename: Efthimia
authors.initials: E
authors.lastname: Zafeiriadou
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Patsiaoura
authors.forename: Evangelia
authors.initials: E
authors.lastname: Katsiki
authors.forename: Christos
authors.initials: C
authors.lastname: Zavos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Papatheodorou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Terpos
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006115:Greece; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D010865:Pilot Projects; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D001219:Aspartate Aminotransferases