title: Circulating sclerostin levels and markers of bone turnover in Chinese-American and white women.
abstract: BACKGROUND
  Chinese-American women have bone microarchitectural features that confer greater bone stiffness compared to white women, but the physiology underlying these findings has not been investigated.
  
  
  OBJECTIVE
  The purpose of the study was to assess racial differences in serum sclerostin and bone turnover markers (BTMs), and to explore their associations with each other, volumetric bone mineral density (BMD), and bone microarchitecture in Chinese-American and white women.
  
  
  METHODS
  We conducted a cross-sectional study at a university hospital.
  
  
  METHODS
  We studied 138 women.
  
  
  RESULTS
  Serum osteocalcin was 19-28% lower in pre- and postmenopausal Chinese-American vs white women, respectively (both P < .01). C-Terminal telopeptide of type I collagen (CTX) level was 18-22% lower in pre- and postmenopausal Chinese-American vs white women (both P < .05). Pre- vs postmenopausal differences in osteocalcin and CTX were greater in white vs Chinese-American women. Sclerostin levels were similar in both races, but BTMs were differentially associated with sclerostin by race and menopausal status. BTMs were not correlated with sclerostin in Chinese-Americans. CTX and bone-specific alkaline phosphatase were positively associated with sclerostin (r = 0.353, r = 0.458; both P < .05) in white premenopausal women. In contrast, in postmenopausal white women, the associations of sclerostin with amino-terminal propeptide of type I procollagen, isoform 5b of tartrate-resistant acid phosphatase, and CTX were negative (all P < .05). Adjusting for covariates, sclerostin was positively associated with areal BMD in both races.
  
  
  CONCLUSIONS
  Lower BTMs in Chinese-American women and greater age-related differences in BTMs among white women provide a physiological framework to account for racial differences in BMD, microarchitecture, and fracture.
authors.affiliation: 630 West 168th Street, PH8 West-864, New York, New York 10032. ac23024@columbia.edu.
authors.forename: Aline G
authors.initials: AG
authors.lastname: Costa
authors.forename: Marcella D
authors.initials: MD
authors.lastname: Walker
authors.forename: Chiyuan A
authors.initials: CA
authors.lastname: Zhang
authors.forename: Serge
authors.initials: S
authors.lastname: Cremers
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Dworakowski
authors.forename: Donald J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: George
authors.initials: G
authors.lastname: Liu
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
mesh_terms: D000135:Acid Phosphatase / Q000097:blood / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D001213:Asian; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D019485:Bone Morphogenetic Proteins / Q000097:blood* / Q000378:metabolism; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D002681:China / Q000208:ethnology; D015331:Cohort Studies; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000453:epidemiology / Q000208:ethnology*; D005819:Genetic Markers; D006785:Hospitals, University; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism; D008593:Menopause / Q000208:ethnology*; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D010455:Peptides / Q000097:blood / Q000378:metabolism; D012307:Risk Factors; D000071681:Tartrate-Resistant Acid Phosphatase; D044465:White People
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D005819:Genetic Markers; D007527:Isoenzymes; D010455:Peptides; C422903:SOST protein, human; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase
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