title: Herbal haemorrhoidal cream for haemorrhoids.
abstract: Although hemorrhoids are one of the most common diseases in the world, the exact etiology underlying the development of hemorrhoids is not clear. Many different ointments are currently used to treat hemorrhoids; however, there is little evidence of the efficacy of these treatments to support their use. The aim of this study was to compare different herbal creams used for the treatment of hemorrhoids. Twenty-eight male Wistar albino rats, 6-8 weeks old and weighing 160-180 g, were used in this study as 1-control, 2-croton oil, 3-croton oil+fig leaves+artichoke leaves+walnut husks and 4-croton oil+fig leaves+artichoke leaves+walnut husks+horse chestnut fruit. After 3 days of croton oil application, rats were treated with 0.1 ml of cream or saline twice a day for 15 days by syringe. Tissue and blood samples were collected for histological, immunohistochemical and biochemical studies. Statistical significance was determined using one-way ANOVA followed by Tukey's multiple comparison tests. Croton oil administration resulted in severe inflammation. The third group showed partial improvement in inflammation; however, the greatest degree of improvement was seen in the fourth group, and some recovered areas were observed. Myeloperoxidase immunoreactivity was found to be decreased in the third and fourth groups compared to the second group. Additionally, biochemical analyses (Myeloperoxidase, Malondyaldehyde, nitrate/nitrite and nitrotyrosine levels and Superoxide Dismutase activity) were in agreement with the histological and immunohistochemical results. In conclusion, croton oil causes inflammation in the anal area and results in hemorrhoids. Treatment with our herbal hemorrhoid creams demonstrated anti-inflammatory and anti-oxidant effects in this model.
authors.affiliation: Department of Biology, Faculty of Science, University of Istanbul, 34134 Vezneciler, Istanbul-Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Gurel
authors.forename: Savas
authors.initials: S
authors.lastname: Ustunova
authors.forename: Bulent
authors.initials: B
authors.lastname: Ergin
authors.forename: Nur
authors.initials: N
authors.lastname: Tan
authors.forename: Metin
authors.initials: M
authors.lastname: Caner
authors.forename: Osman
authors.initials: O
authors.lastname: Tortum
authors.forename: Cihan
authors.initials: C
authors.lastname: Demirci-Tansel
mesh_terms: D000287:Administration, Topical; D031319:Aesculus; D000818:Animals; D003436:Croton Oil; D031943:Cynara scolymus; D004353:Drug Evaluation, Preclinical; D030681:Ficus; D006484:Hemorrhoids / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D031324:Juglans; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D063465:Skin Cream
chemical_list: D028321:Plant Preparations; D003436:Croton Oil; D009195:Peroxidase