title: Duloxetine prophylaxis for episodic migraine in persons without depression: a prospective study.
abstract: OBJECTIVE
  The objective of this pilot study is to evaluate the effects of daily duloxetine, 60-120 mg, on the frequency, duration, and severity of migraine attacks and the level of disability in episodic migraineurs.
  
  
  BACKGROUND
  There is a need for more proven effective migraine preventive medications. Two antidepressants, both of which block serotonin and norepinephrine reuptake, have been shown to be effective in the preventive treatment of migraine. Neither has earned a level A recommendation in the 2012 guidelines of the American Academy of Neurology. Duloxetine also blocks serotonin and norepinephrine reuptake.
  
  
  METHODS
  This was a prospective, 5-visit study on duloxetine treatment of episodic migraine headache with 4-10 migraine days, and less than 15 headache days per month. Patients were titrated to a goal dose of 120 mg. They were excluded if they had depression.
  
  
  RESULTS
  There were 22 completers plus 5 subjects who took at least 1 dose of drug. The mean duloxetine dose was 110 mg. In a modified intent-to-treat analysis, subjects went from 9.2 ± 2.7 headache days per month at baseline to 4.5 ± 3.4 headache days per month (P < .001). There were no significant differences in the average headache duration, average headache severity, maximum headache attack severity, and level of functioning. Fifty-two percent of subjects had a 50% or greater improvement in headache days.
  
  
  CONCLUSIONS
  Migraine prophylactic treatment with high-dose duloxetine may be effective in a nondepressed individual. The reported treatment response is in line with other commonly used migraine preventives.
authors.affiliation: Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Young
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Bradley
authors.forename: M Waseem
authors.initials: MW
authors.lastname: Anjum
authors.forename: Cheryl
authors.initials: C
authors.lastname: Gebeline-Myers
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000188:drug therapy* / Q000523:psychology; D010865:Pilot Projects; D011446:Prospective Studies; D013876:Thiophenes / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride
keywords: duloxetine; migraine; migraine prevention; migraine preventive; prospective trial; serotonin reuptake inhibitor