title: [Distribution and regulation of Panx1 protein].
abstract: Pannexin1 (Panx1) is a subtype of the newly discovered gap junction proteins named Pannexin(s). Panx1 is widely expressed in the nervous system, cardiovascular system, etc and can form non-selective and large conductance hemichannel. It has been demonstrated that various conditions can regulate Panx1 open and affect the body's physiological function via macromolecular substance (for instance, ATP) releasing. This review gives a detailed introduction to the main distribution of Panxl, summarizes the open and inhibition condition of Panx1, and finally, prospects directions of future research.
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Xiang-Xing
authors.initials: XX
authors.lastname: Kong
authors.forename: Bin-Yin
authors.initials: BY
authors.lastname: Li
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Guan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology; D017630:Connexins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D014018:Tissue Distribution
chemical_list: D017630:Connexins; D009419:Nerve Tissue Proteins; C492764:PANX1 protein, human; D000255:Adenosine Triphosphate; D002229:Carbenoxolone