title: Effect of different suprahepatic vena cava reconstruction methods on the hemodynamics of rats after liver transplantation.
abstract: BACKGROUND
  There are few studies on the hemodynamic changes after orthotopic liver transplantation in rats. In this study, we aimed to evaluate the effect of different suprahepatic vena cava (SHVC) reconstruction methods on the hemodynamics of rats after liver transplantation.
  
  
  METHODS
  Three rat liver transplantation groups were created according to the SHVC reconstruction method: Kamada's two-cuff technique, a modified veno-lined stent technique, and Harihara's three-cuff technique. Ten rats of similar weight were grouped as the control. Anatomical, ultrasonic, and hemodynamic parameters and the microcirculation of the liver were measured after transplantation. The detailed operation time, operative complications, and animal survival were recorded.
  
  
  RESULTS
  All the recipients showed portal hypertension one month after transplantation. The portal hypertension in the group with the modified veno-lined stent technique was the most severe. The value measured with real-time elastography was significantly higher in the recipients using the modified veno-lined stent technique than in the other two groups (P<0.01). There was no difference in the graft microcirculation after reperfusion among the three groups. The survival rate of the three groups displayed no difference, but the modified veno-lined stent technique led to more venous complications than the other two techniques.
  
  
  CONCLUSIONS
  The hemodynamics after liver transplantation in rats is determined not only by the cuff used for portal vein reconstruction but also by the cuff or stent for the SHVC. Some SHVC reconstruction methods, such as the modified veno-lined stent technique, Miyata's or Settaf's three-cuff techniques, significantly affect the hemodynamics.
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, China.
authors.forename: Hongdong
authors.initials: H
authors.lastname: Wang
authors.forename: Chonghui
authors.initials: C
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Hu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Xu
authors.forename: Xu
authors.initials: X
authors.lastname: Ji
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.forename: Xuedong
authors.initials: X
authors.lastname: Wang
authors.forename: Yukun
authors.initials: Y
authors.lastname: Luo
authors.forename: Hailin
authors.initials: H
authors.lastname: Li
authors.forename: Kesen
authors.initials: K
authors.lastname: Xu
authors.forename: Sheng
authors.initials: S
authors.lastname: Ye
authors.forename: Aiqun
authors.initials: A
authors.lastname: Zhang
authors.forename: Jiahong
authors.initials: J
authors.lastname: Dong
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000502:physiology*; D006503:Hepatic Veins / Q000502:physiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014682:Vena Cava, Inferior / Q000502:physiology / Q000601:surgery*
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