title: Endothelial and platelet function in children with previous Kawasaki disease.
abstract: We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Laurito
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Stazi
authors.affiliation: Institute of Pediatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Angelica B
authors.initials: AB
authors.lastname: Delogu
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Milo
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Irma
authors.initials: I
authors.lastname: Battipaglia
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Giancarla
authors.initials: G
authors.lastname: Scalone
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Infusino
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Villano
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Russo
authors.affiliation: Institute of Pediatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Iannotta
authors.affiliation: Institute of Pediatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Saracino
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Parrinello
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Figliozzi
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Sestito
authors.affiliation: Institute of Pediatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy g.a.lanza@rm.unicatt.it.
authors.forename: Gaetano A
authors.initials: GA
authors.lastname: Lanza
authors.affiliation: Institute of Cardiology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000502:physiology*; D059168:Carotid Intima-Media Thickness; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000503:physiopathology*; D015539:Platelet Activation / Q000502:physiology*; D010974:Platelet Aggregation / Q000502:physiology*; D010979:Platelet Function Tests / Q000379:methods
keywords: Kawasaki disease; carotid intima-medial thickness; endothelial function; platelet function