title: The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system.
abstract: The Slit/Robo axon guidance families play a vital role in the formation of neural circuitry within select regions of the developing mouse nervous system. Typically Slits signal through the Robo receptors, however they also have Robo-independent functions. The novel Slit receptor Eva-1, recently discovered in C. elegans, and the human orthologue of which is located in the Down syndrome critical region on chromosome 21, could account for some of these Robo independent functions as well as provide selectivity to Robo-mediated axon responses to Slit. Here we investigate the expression of the mammalian orthologue EVA1C in regions of the developing mouse nervous system which have been shown to exhibit Robo-dependent and -independent responses to Slit. We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain. Furthermore it is expressed by axons that display both Robo-dependent and -independent functions of Slit, supporting a role for EVA1C in Slit/Robo mediated neural circuit formation in the developing nervous system.
authors.affiliation: School of Biomedical Science, University of Queensland, Brisbane, Australia.
authors.forename: Gregory
authors.initials: G
authors.lastname: James
authors.forename: Simon R
authors.initials: SR
authors.lastname: Foster
authors.forename: Brian
authors.initials: B
authors.lastname: Key
authors.forename: Annemiek
authors.initials: A
authors.lastname: Beverdam
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D015870:Gene Expression; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009420:Nervous System / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013788:Thalamus / Q000166:cytology / Q000378:metabolism
chemical_list: C000588813:EVA1C protein, mouse; D011956:Receptors, Cell Surface
references.citation: Neuron. 1991 Mar;6(3):381-96
references.pmid: 2001285
references.citation: J Comp Neurol. 2001 May 28;434(2):147-57
references.pmid: 11331522
references.citation: J Neurosci. 2000 Jul 1;20(13):4975-82
references.pmid: 10864955
references.citation: J Neurosci. 2006 Jun 28;26(26):6911-23
references.pmid: 16807321
references.citation: Development. 2008 Nov;135(22):3643-53
references.pmid: 18842816
references.citation: J Anat. 2007 Aug;211(2):188-98
references.pmid: 17553100
references.citation: Cell. 2011 Jan 7;144(1):106-18
references.pmid: 21215373
references.citation: Development. 2001 Dec;128(24):5031-7
references.pmid: 11748139
references.citation: J Comp Neurol. 1994 Jul 1;345(1):1-32
references.pmid: 8089271
references.citation: J Neurosci. 2009 Jul 15;29(28):8914-26
references.pmid: 19605629
references.citation: Annu Rev Neurosci. 2008;31:295-315
references.pmid: 18558857
references.citation: J Biochem. 2009 Sep;146(3):369-73
references.pmid: 19470522
references.citation: J Neurosci. 2012 Oct 31;32(44):15377-87
references.pmid: 23115176
references.citation: J Neurosci. 2000 Jul 1;20(13):4962-74
references.pmid: 10864954
references.citation: Hum Mol Genet. 2007 Apr 1;16(7):774-82
references.pmid: 17339268
references.citation: Development. 2006 Jun;133(11):2243-52
references.pmid: 16690755
references.citation: J Neurosci. 2007 Jun 20;27(25):6843-51
references.pmid: 17581972
references.citation: PLoS One. 2011;6(5):e19887
references.pmid: 21655271
references.citation: Dev Biol. 1999 Aug 15;212(2):290-306
references.pmid: 10433822
references.citation: Eur J Neurosci. 1990;2(6):487-499
references.pmid: 12106019
references.citation: J Neurosci. 2007 Mar 28;27(13):3395-407
references.pmid: 17392456
references.citation: J Comp Neurol. 1982 Jun 1;207(4):333-43
references.pmid: 7119146
references.citation: J Comp Neurol. 1982 Sep 1;210(1):10-29
references.pmid: 7130467
references.citation: Dev Dyn. 2005 May;233(1):41-51
references.pmid: 15768400
references.citation: Cereb Cortex. 2009 Jul;19 Suppl 1:i11-21
references.pmid: 19357391
references.citation: Dev Neurosci. 2004 Mar-Aug;26(2-4):255-65
references.pmid: 15711065
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1019-27
references.pmid: 18270976
references.citation: Dev Biol. 2012 Nov 15;371(2):269-79
references.pmid: 22981605
references.citation: Mol Cell Neurosci. 2008 Apr;37(4):719-30
references.pmid: 18272390
references.citation: J Neurosci. 2007 Aug 22;27(34):9094-104
references.pmid: 17715346
references.citation: Brain Struct Funct. 2014 May;219(3):861-74
references.pmid: 23525682
references.citation: J Neurosci. 2010 Jul 14;30(28):9445-53
references.pmid: 20631173
references.citation: Science. 2007 Sep 28;317(5846):1934-8
references.pmid: 17901337
references.citation: J Comp Neurol. 2004 Jan 19;468(4):467-81
references.pmid: 14689480
references.citation: J Biol Chem. 2006 Dec 22;281(51):39693-8
references.pmid: 17062560
references.citation: Cell. 1996 Dec 13;87(6):1001-14
references.pmid: 8978605
references.citation: Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a001784
references.pmid: 20300212
references.citation: Birth Defects Res C Embryo Today. 2007 Sep;81(3):204-14
references.pmid: 17963275
references.citation: EMBO J. 2011 Jun 14;30(14):2920-33
references.pmid: 21673655
references.citation: Neuron. 2008 May 8;58(3):325-32
references.pmid: 18466743
references.citation: Curr Biol. 2008 Dec 23;18(24):1978-85
references.pmid: 19062279
references.citation: Development. 2010 Jun;137(12):1939-52
references.pmid: 20501589
references.citation: Neuron. 2004 Apr 22;42(2):213-23
references.pmid: 15091338
references.citation: Am J Med Genet A. 2012 Jan;158A(1):199-205
references.pmid: 22106086
references.citation: J Neurosci. 1994 Nov;14(11 Pt 1):6608-20
references.pmid: 7965064
references.citation: J Neurosci. 2011 Oct 5;31(40):14051-66
references.pmid: 21976490
references.citation: Neuron. 2002 Jan 17;33(2):233-48
references.pmid: 11804571
references.citation: Development. 2012 Apr;139(8):1435-46
references.pmid: 22399681
references.citation: J Neurosci. 2008 Apr 16;28(16):4244-9
references.pmid: 18417704
references.citation: Dev Biol. 2012 May 1;365(1):36-49
references.pmid: 22349628
references.citation: Dev Biol. 2006 Aug 15;296(2):476-84
references.pmid: 16828733
references.citation: J Neurosci. 2011 Feb 9;31(6):1955-70
references.pmid: 21307234
references.citation: Nat Neurosci. 2012 Jan 29;15(3):389-98, S1-2
references.pmid: 22286174
references.citation: Science. 2004 Jun 4;304(5676):1509-13
references.pmid: 15105459
references.citation: J Comp Neurol. 1999 Oct 18;413(2):289-304
references.pmid: 10524340
references.citation: Neuron. 2002 Jan 17;33(2):219-32
references.pmid: 11804570
references.citation: Neurosci Lett. 2013 Jun 17;545:11-6
references.pmid: 23603263
references.citation: Neuron. 2013 Feb 6;77(3):472-84
references.pmid: 23395374