title: One-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles via a multicomponent [4 + 1] cycloaddition reaction.
abstract: A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.
authors.affiliation: Department of Applied Chemistry, National Chiao-Tung University , Hsinchu 300-10, Taiwan.
authors.forename: Ya-Shan
authors.initials: YS
authors.lastname: Hsiao
authors.forename: Bharat D
authors.initials: BD
authors.lastname: Narhe
authors.forename: Ying-Sheng
authors.initials: YS
authors.lastname: Chang
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003486:Cyanides / Q000737:chemistry; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D001562:Benzimidazoles; D003486:Cyanides; C492520:imidaso(1,2-a)benzimidazole