title: Optimization of sustained release matrix tablet of metoprolol succinate using central composite design.
abstract: The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix combination. After investigating the effects of various parameters on drug release, a 2-factor, 5-level central composite design was employed, using the amount of HPMC K4M (A) and SA (318 cP) (B) as the independent variables and the drug percentage released at 1h, 4h, 8h, 20h (Q1, Q4, Q8, Q20) as the responses. Response surfaces were established to obtain the matrix ranges and the main factors affecting four responses. In order to validate the optimization study, six confirmatory runs were performed; indicating high predictability of response surface methodology for MS sustained release tablets. Data fitting to Peppas equation indicated that the mechanism of drug release could be diffusion along with erosion. This matrix combination can be used as a good alternative to the commercially pellet technology, which was complicated, time-consuming and energy-intensive.
authors.affiliation: Department of Pharmacy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Huijuan
authors.initials: H
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000737:chemistry; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D014783:Viscosity
chemical_list: D000319:Adrenergic beta-Antagonists; D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D013607:Tablets; D065347:Hypromellose Derivatives; D020723:Glucuronic Acid; D008747:Methylcellulose; D008790:Metoprolol