title: Interdisciplinary management of congenital infiltrating lipomatosis.
abstract: Congenital infiltrating lipomatosis is a benign yet locally invasive lipomatous tumor. Current treatment involves surgical excision and reconstruction of craniofacial deformity. Invasion of vital structures often makes complete resection problematic and recurrence is common. We present the case of a 15-year-old female patient with extensive congenital infiltrating lipomatosis involving the left face. A broad treatment algorithm was devised involving surgical resection as well as targeted chemotherapy. At 18 month follow-up the patient demonstrated improved facial symmetry without evidence of disease progression. Combining surgical and medical intervention may allow for a synergistic approach to controlling this rare disease.
authors.affiliation: Department of Otolaryngology, Tufts Medical Center, Boston, MA, United States. Electronic address: jtracy@tuftsmedicalcenter.org.
authors.forename: Jeremiah C
authors.initials: JC
authors.lastname: Tracy
authors.forename: Giannoula Lakka
authors.initials: GL
authors.lastname: Klement
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Scott
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D005153:Facial Neoplasms / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008068:Lipomatosis / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D035583:Rare Diseases; D017479:Receptors, Platelet-Derived Growth Factor / Q000008:administration & dosage*; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D017479:Receptors, Platelet-Derived Growth Factor
keywords: Benign neoplasms; CIL; CT; Chemotherapy; Facial plastic surgery; Head and neck surgery; MR; Oncology; PDGF-R; computed tomography; congenital infiltrating lipomatosis; magnetic resonance; platelet derived growth factor receptor