title: The ins and outs of hepatitis C virus entry and assembly.
abstract: Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.
authors.affiliation: Department of Microbial Pathogenesis, Yale University, New Haven, Connecticut 06536, USA.
authors.forename: Brett D
authors.initials: BD
authors.lastname: Lindenbach
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rice
mesh_terms: D000818:Animals; D011992:Endosomes / Q000821:virology; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D011991:Receptors, Virus / Q000378:metabolism; D060225:Tetraspanin 28 / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D019065:Virus Assembly; D053586:Virus Internalization; D057074:Virus Release
chemical_list: C554799:Cd81 protein, mouse; D011991:Receptors, Virus; D060225:Tetraspanin 28; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus
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