title: Bilateral submandibular gland aplasia with hypertrophy of the sublingual glands of a patient with a cleft lip and palate: case report.
abstract: Aplasia of major salivary glands is a rare disorder with only a handful of cases reported in the literature. The cause of congenital absence of the salivary glands has not been determined, but it may be associated with ectodermal defects of the first and second branchial arches. Patients may be asymptomatic or may experience dysphagia, xerostomia, several periodontal disease, or multiple caries. There are few reports of patients with congenital gland aplasia with cleft lip and palate. We document the case of a 41-year-old patient with repaired unilateral cleft lip palate, bilateral submandibular gland aplasia, and compensatory hypertrophy of the sublingual glands. To the best of our knowledge, there are no previous reports that can be found in the literature with a combination of such findings.
authors.affiliation: From the Department of Oral and Maxillofacial Surgery.
authors.forename: María Fe García
authors.initials: MF
authors.lastname: Reija
authors.forename: Diana Patricia Lopez
authors.initials: DP
authors.lastname: Gordillo
authors.forename: Julia Cayetana Blasco
authors.initials: JC
authors.lastname: Palacio
authors.forename: Laura Bermejo
authors.initials: LB
authors.lastname: Abascal
authors.forename: Belén García-Montesinos
authors.initials: BG
authors.lastname: Perea
mesh_terms: D000328:Adult; D002971:Cleft Lip / Q000150:complications* / Q000601:surgery; D002972:Cleft Palate / Q000150:complications* / Q000601:surgery; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D012469:Salivary Glands / Q000002:abnormalities*