title: A β-boronopeptide bundle of known structure as a vehicle for polyol recognition.
abstract: Despite significant progress in the design of receptors and sensors for simple polyols and monosaccharides, few synthetic receptors discriminate among multiple saccharide units simultaneously, especially under physiological conditions. Described here is the three-dimensional structure of a supramolecular complex-a β-peptide bundle-designed for the potential to interact simultaneously with as many as eight discrete monosaccharide units. The preliminary evaluation of this construct as a vehicle for polyol binding is also presented.
authors.affiliation: Department of Chemistry, Department of Molecular Biophysics and Biochemistry, and Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut 06520-8107, United States.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Melicher
authors.forename: John
authors.initials: J
authors.lastname: Chu
authors.forename: Allison S
authors.initials: AS
authors.lastname: Walker
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Miller
authors.forename: Richard H G
authors.initials: RH
authors.lastname: Baxter
authors.forename: Alanna
authors.initials: A
authors.lastname: Schepartz
mesh_terms: D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D009005:Monosaccharides; D010455:Peptides; D011108:Polymers; C024617:polyol