title: Seroprevalences of varicella-zoster virus, herpes simplex virus and cytomegalovirus in a cross-sectional study in Mexico.
abstract: We estimated the seroprevalences of varicella-zoster virus (VZV), herpes simplex virus (HSV) and cytomegalovirus (CMV) in this cross-sectional database study. Serum samples collected during the National Health and Nutrition survey (ENSANUT 2006) were obtained from subjects aged 1-70 years between January and October 2010. Serological assays for the determination of antibodies against VZV, HSV and CMV were performed. The overall seroprevalences of VZV, HSV-1, HSV-2 and CMV were 85.8%, 80.9%, 9.9% and 89.2%, respectively. Seroprevalences of VZV, HSV-1 and CMV were comparable between males and females. For HSV-2, although the seroprevalence rate was higher in females when compared to males, this difference in seroprevalence was not statistically significant. Seroprevalence rates for VZV, HSV-1, HSV-2 and CMV increased with age (p-value<.0001). Differences in seroprevalence rate for VZV by socioeconomic status (SES) were significant (p-value<0001). Results of the serological analyses reported high VZV seroprevalence, indicating high transmission in the Mexican population with children and adolescents at risk of acquiring VZV. Global HSV-1 seroprevalence was high, especially in adults. HSV-1 and HSV-2 seroprevalences were consistently higher in women than men, particularly for HSV-2. CMV seroprevalence was higher in Mexico when compared to developed countries. Seroepidemiological data on VZV supports the fact that varicella vaccination may serve as an alternative effective solution to reduce transmission in the Mexican population. For CMV and HSV, since no vaccines are available, activities to reduce transmission are important to reduce the risk of complications and therefore need to be considered.
authors.affiliation: Instituto Nacional de Salud Pública (INSP), Avenida Universidad 655, Colonia Santa María Ahuacatitlán 62508 Cuernavaca, Morelos, Mexico. Electronic address: cjconde@insp.mx.
authors.forename: Carlos
authors.initials: C
authors.lastname: Conde-Glez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.forename: Rosalba
authors.initials: R
authors.lastname: Rojas
authors.forename: Rodrigo
authors.initials: R
authors.lastname: DeAntonio
authors.forename: Luis
authors.initials: L
authors.lastname: Romano-Mazzotti
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Cervantes
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barria
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus / Q000302:isolation & purification*; D005260:Female; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D018139:Simplexvirus / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: CI; CMV; Cytomegalovirus; ELISA; ENSANUT; HSV; Herpes simplex; Mexico; National Health and Nutrition Survey; SAS; SES; Seroprevalence; VZV; Varicella zoster; confidence interval; cytomegalovirus; enzyme-linked immunosorbent assay; herpes simplex virus; socioeconomic status; statistical analysis software; varicella-zoster virus