title: Primary intraocular inflammatory myofibroblastic tumor with anaplastic lymphoma kinase overexpression.
abstract: The human eye can be compromised by a variated spectrum of neoplasms and reactive processes. Here we present a rare case of a primary intraocular inflammatory myofibroblastic tumor (IMT) dependent on the sclera and choroid in a 31-year-old female. The knowledge surrounding IMTs, previously included in the category of inflammatory pseudotumors, has undergone dynamic changes in the past two decades. Here we review the characteristics of these tumors in the human eye and in the surrounding structures, and we describe the recent advances that allow molecular characterization of the neoplastic nature of this entity.
authors.affiliation: National Institute of Cancer, Bogotá D.C, Colombia.
authors.forename: Alfredo E
authors.initials: AE
authors.lastname: Romero-Rojas
authors.forename: Julio A
authors.initials: JA
authors.lastname: Diaz-Perez
authors.forename: Melina
authors.initials: M
authors.lastname: Mastrodimos
authors.forename: Jose
authors.initials: J
authors.lastname: Szelezsan
authors.forename: Oscar
authors.initials: O
authors.lastname: Messa-Botero
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D005134:Eye Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D047708:Myofibroma / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015422:Scleral Diseases / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
references.citation: Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):643-9
references.pmid: 22836055
references.citation: Am J Pathol. 2001 Aug;159(2):411-5
references.pmid: 11485898
references.citation: Ophthalmology. 2001 Jun;108(6):1129-33
references.pmid: 11382641
references.citation: Ophthalmology. 1987 Apr;94(4):397-406
references.pmid: 3295641
references.citation: PLoS One. 2013;8(1):e50812
references.pmid: 23300945
references.citation: Mod Pathol. 2001 Aug;14(8):784-90
references.pmid: 11504838
references.citation: Am J Pathol. 2000 Aug;157(2):377-84
references.pmid: 10934142
references.citation: J Pediatr Surg. 2005 Oct;40(10):1581-6
references.pmid: 16226988
references.citation: J AAPOS. 1998 Apr;2(2):120-3
references.pmid: 10530975
references.citation: Am J Ophthalmol. 1971 Sep;72(3):586-91
references.pmid: 5568609
references.citation: Hum Pathol. 2008 Jun;39(6):846-56
references.pmid: 18400254
references.citation: Cancer Res. 1999 Jun 15;59(12):2776-80
references.pmid: 10383129
references.citation: J Child Neurol. 2008 Apr;23(4):425-30
references.pmid: 18192646
references.citation: AJR Am J Roentgenol. 2009 Oct;193(4):1180-6
references.pmid: 19770345
references.citation: Am J Clin Oncol. 2010 Jun;33(3):304-6
references.pmid: 19738455
references.citation: Rom J Morphol Embryol. 2011;52(3):927-30
references.pmid: 21892541
references.citation: Arch Ophthalmol. 2001 Apr;119(4):603-7
references.pmid: 11296029
references.citation: Ophthalmic Plast Reconstr Surg. 2005 May;21(3):211-5
references.pmid: 15942497
references.citation: Orbit. 2004 Dec;23(4):245-54
references.pmid: 15590527
references.citation: Surv Ophthalmol. 1997 May-Jun;41(6):467-76
references.pmid: 9220569
references.citation: Am J Surg Pathol. 2007 Apr;31(4):509-20
references.pmid: 17414097
references.citation: Histopathology. 1995 Oct;27(4):313-23
references.pmid: 8847061
references.citation: Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1496-502
references.pmid: 21035962
references.citation: Ophthalmology. 2001 Sep;108(9):1603-6
references.pmid: 11535457
references.citation: Arch Pathol Lab Med. 2004 Jan;128(1):e5-7
references.pmid: 14692830
references.citation: Am J Clin Pathol. 1990 Nov;94(5):538-46
references.pmid: 2239820
references.citation: Orbit. 2006 Mar;25(1):1-4
references.pmid: 16527767
references.citation: Ophthalmology. 1983 Dec;90(12):1422-5
references.pmid: 6687156
references.citation: Am J Ophthalmol. 1967 Sep;64(3):Suppl:612-21
references.pmid: 6039083
references.citation: Mod Pathol. 2011 Apr;24(4):606-12
references.pmid: 21297584