title: Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.
abstract: OBJECTIVE
  Genetic factors are shown to have a role in the development of primary open angle glaucoma (POAG). The aim of this study was to determine the effects of genetic polymorphisms of transient receptor potential melastatin (TRPM) channel genes on the risk of POAG in a Turkish population.
  
  
  METHODS
  Genomic DNA was extracted from the leukocytes of the peripheral blood, and 26 single nucleotide polymorphisms in the TRPM channel genes were analyzed in 179 patients with POAG and in 182 healthy controls of similar age by using the BioMark HD dynamic array system.
  
  
  RESULTS
  There were marked changes in the genotype (TT, 26.8%; CT, 66.7%; CC, 6.5%) and allele (T, 60.1%; C, 39.9%) frequencies for the TRPM5 gene rs34551253 (Ala456Thr, in exon 9) polymorphism in patients when compared to the controls (TT, 11.3%; CT, 74.6%; CC, 14.1%, p = 0.0009; T, 48.6%; A, 51.4%, p = 0.0063). However, no associations with the other 25 polymorphisms studied were found.
  
  
  CONCLUSIONS
  This is the first study to examine the involvement of TRPM channel gene variations in the risk of incident POAG. This study demonstrated that the TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing POAG in the Turkish population.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Seydi
authors.initials: S
authors.lastname: Okumus
authors.forename: Seniz
authors.initials: S
authors.lastname: Demiryürek
authors.forename: Bülent
authors.initials: B
authors.lastname: Gürler
authors.forename: Erol
authors.initials: E
authors.lastname: Coskun
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Bozgeyik
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztuzcu
authors.forename: Erdal
authors.initials: E
authors.lastname: Kaydu
authors.forename: Oguz
authors.initials: O
authors.lastname: Celik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Erbagcı
authors.forename: Abdullah T
authors.initials: AT
authors.lastname: Demiryürek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050053:TRPM Cation Channels / Q000235:genetics*
chemical_list: D050053:TRPM Cation Channels
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