title: IL-17 producing T cells in celiac disease: angels or devils?
abstract: Celiac disease (CD) is a very common chronic condition in human beings, affecting approximately one in 100 individuals. It is an autoimmune disease with a defined environmental trigger, the gluten contained in dietary cereals, occurring in genetically susceptible individuals. The disease has a very strong HLA association. More than 90% of CD patients have HLA-DQ2, and almost all of the remaining celiac population possesses HLA-DQ8 molecules. Th17 cells seem to participate in the disease pathogenesis producing and secreting either proinflammatory or anti-inflammatory cytokines.
authors.affiliation: Department of Immunology, School of Medicine, University of Córdoba , Córdoba , Spain.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Ortega
authors.forename: Silvia
authors.initials: S
authors.lastname: Fernández
authors.forename: Orlando A
authors.initials: OA
authors.lastname: Estévez
authors.forename: Rocío
authors.initials: R
authors.lastname: Aguado
authors.forename: Ignacio J
authors.initials: IJ
authors.lastname: Molina
authors.forename: Manuel
authors.initials: M
authors.lastname: Santamaría
mesh_terms: D002446:Celiac Disease / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism*
chemical_list: D016207:Cytokines; D020381:Interleukin-17