title: Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
abstract: A 36-year-old female was hospitalized with symptoms suggesting intestinal occlusion. She was diagnosed with adenocarcinoma of the ampulla of Vater (pT4N0 stage) and underwent cephalic duodenopancreatectomy 8 months ago. Five cycles of postoperative chemotherapy were administrated using capecitabine and oxaliplatin (CAPOX or XELOX), the last one being completed 1 month ago. During the present hospitalization, because of normal computed tomography and ultrasound abdominal examination, rehydration and antibiotherapy were administrated. However, 4 days after hospital admission, the patient died. At autopsy and histological examination, we found a severe myocardial sclerosis with large scarring areas, severe steatohepatitis, chronic pancreatitis with large fibrotic areas, and acute enteritis. Alcohol consumption was denied. The patient died due to associated heart, liver and pancreatic failure. This multiorgan toxicity and death following CAPOX regimen had not yet been reported in the literature.
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authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Tirgu-Mures, Romania. simonagurzu@yahoo.com.
authors.forename: Simona
authors.initials: S
authors.lastname: Gurzu
authors.forename: Ioan
authors.initials: I
authors.lastname: Jung
authors.forename: Maria
authors.initials: M
authors.lastname: Comsulea
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kadar
authors.forename: Leonard
authors.initials: L
authors.lastname: Azamfirei
authors.forename: Calin
authors.initials: C
authors.lastname: Molnar
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000328:Adult; D014670:Ampulla of Vater / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001344:Autopsy; D000069287:Capecitabine; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003138:Common Bile Duct Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives; D004751:Enteritis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D005234:Fatty Liver / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D009102:Multiple Organ Failure / Q000139:chemically induced; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000009:adverse effects; D000077150:Oxaliplatin; D010071:Oxaloacetates; D016577:Pancreaticoduodenectomy; D050500:Pancreatitis, Chronic / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D009944:Organoplatinum Compounds; D010071:Oxaloacetates; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil
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