title: [Hand and wrist bone maturation in children with central precocious puberty and idiopathic short stature].
abstract: OBJECTIVE
  To investigate the maturation of individual bones on the hand and wrist in children with central precocious puberty (CPP) and idiopathic short stature (ISS).
  
  
  METHODS
  Hand and wrist films of 25 children with CPP, 29 children with ISS and 21 normal controls were evaluated by conventional Greulich-Pyle (GP) atlas method and individual bone assessment method, in which all twenty bones of the hand and wrist were evaluated based on GP atlas, including 2 radius and ulna, 7 carpal bones, 11 metacarpal and phalangeal bones, the average bone age (BA) was calculated. The differences in groups were analyzed by independent samples t test. The differences between the two methods were analyzed by paired sample t test. The differences between BA and chronological age (CA) were analyzed by ROC with SPSS 17.0.
  
  
  RESULTS
  Compared with the normal control group, the advance of BA in the CPP group was 0.70-2.26 y (1.48 ±0.78) by the GP atlas method, while that was 0.28-2.00 y(1.14 ±0.86) by the individual bone evaluation method. In all twenty bones, the advance of metacarpal and phalangeal BA was the greatest [0.34-2.06 y(1.2±0.86)]. In the ISS group,the delay of BA was 0.47-2.91 y(-1.69±1.22) by the GP atlas method, while that was 0.48-2.50 y (-1.49±1.01) by individual bone evaluation method.The delay of carpal BA was the greatest [0.59-2.73 y(-1.66±1.07)] in all twenty bones. In the ISS group and the normal control group, there were no statistic differences between the two methods. In the CPP group, statistic difference was found between two methods. There were no statistic differences for the areas under ROC curves between two methods.
  
  
  CONCLUSIONS
  The advance of metacarpal and phalangeal BA is the greatest in CPP group and the delay of carpal BA is the greatest in ISS group.Both methods provide diagnostic information for bone age in CPP and ISS children.
authors.affiliation: Department of Pediatric Endocrinology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China.
authors.forename: Anru
authors.initials: A
authors.lastname: Wang
authors.forename: Fangling
authors.initials: F
authors.lastname: Yang
authors.forename: Baosheng
authors.initials: B
authors.lastname: Yu
authors.forename: Ye
authors.initials: Y
authors.lastname: Shan
authors.forename: Lanying
authors.initials: L
authors.lastname: Gao
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Ya
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000365:Age Determination by Skeleton / Q000379:methods*; D002348:Carpal Bones / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002648:Child; D004392:Dwarfism / Q000000981:diagnostic imaging*; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000000981:diagnostic imaging*