title: Tunable synthesis of 3-acyl-2-naphthols and 3-substituted isocoumarins via Jones reagent promoted cascade reactions of 2-(4-hydroxy-but-1-ynyl)benzaldehydes.
abstract: Novel and efficient synthesis of 3-acyl-2-naphthols and 3-substituted isocoumarins via the tunable cascade reactions of 2-(4-hydroxy-but-1-ynyl)benzaldehydes have been developed. Treatment of 2-(4-hydroxy-but-1-ynyl)benzaldehydes with 0.7 equiv of Jones reagent in CH3CN and subsequent purification through column chromatography on silica gel pre-eluted with Et3N afforded 3-acyl-2-naphthols with high efficiency. When the same substrates were treated with 3 equiv of Jones reagents in acetone, on the other hand, 3-substituted isocoumarins could be obtained in good yields.
authors.affiliation: School of Environment, Key Laboratory for Yellow River and Huai River Water Environment and Pollution Control, Ministry of Education, Henan Normal University , Xinxiang, Henan 453007, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Nana
authors.initials: N
authors.lastname: Shen
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan