title: Benzopyran derivatives as cardio-selective ATP-sensitive potassium channel openers: a review.
abstract: Benzopyran derivatives are the potassium channel openers (KCOs) having antihypertensive, cardio-protective, myocardial protectors, powerful peripheral vasodilators and anti-ischemic activity. Their usage as anti-ischemic including angina, hypertension and diabetes is thought to be due to the stimulation of KATP channels which are contemplated to produce vasorelaxation and myocardial protection. It is observed that potassium channels are involved in mediating the cardio-protective effects of pre-conditioning in animal models and man. KCOs protect heart from an ischemic insult without contribution from vasodilatation. This review provides an overview of the characteristics of KCOs and their actions on subtypes used widely for the treatments of various diseases including hypertension, cardiac ischemia, arrhythmia, smooth muscle relaxation, diabetes, cardio-protective and anti-angiogenic activities.
authors.affiliation: Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad-382481, Gujarat, India. manjunath.ghate@nirmauni.ac.in.
authors.forename: Mohsina
authors.initials: M
authors.lastname: Bano
authors.forename: Kuldipsinh P
authors.initials: KP
authors.lastname: Barot
authors.forename: Shaik Miftah
authors.initials: SM
authors.lastname: Ahmed
authors.forename: Stoyanka
authors.initials: S
authors.lastname: Nikolova
authors.forename: Illiyan
authors.initials: I
authors.lastname: Ivanov
authors.forename: Manjunath D
authors.initials: MD
authors.lastname: Ghate
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000188:drug therapy; D054086:KATP Channels / Q000737:chemistry / Q000378:metabolism*; D009126:Muscle Relaxation / Q000187:drug effects; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D001578:Benzopyrans; D002316:Cardiotonic Agents; D054086:KATP Channels; D014665:Vasodilator Agents