title: The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis.
abstract: To determine if complement anaphylatoxin-mediated inflammation contributes to the development and progression of experimental autoimmune uveitis (EAU), we induced disease in wild type and complement anaphylatoxin receptor-deficient mice (C3a receptor(-/-), C5a receptor(-/-) and C3aR(-/-)/C5aR(-/-)) and evaluated the eyes three weeks post-induction. No differences in disease severity or in disease incidence were seen between wild type controls and anaphylatoxin receptor-deficient mice. Our data indicate that C3a and C5a-mediated functions are not critical to the development of EAU.
authors.affiliation: Department of Ophthalmology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Pathology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA; Department of Microbiology, The University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294-1150, USA. Electronic address: rwr@uab.edu.
authors.forename: Russell W
authors.initials: RW
authors.lastname: Read
authors.forename: Susan D
authors.initials: SD
authors.lastname: Vogt
authors.forename: Scott R
authors.initials: SR
authors.lastname: Barnum
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D044087:Receptor, Anaphylatoxin C5a / Q000235:genetics; D011951:Receptors, Complement / Q000235:genetics; D014608:Uveoparotid Fever / Q000139:chemically induced / Q000235:genetics / Q000276:immunology / Q000473:pathology*
chemical_list: C470184:CLECL1 protein, human; D037181:Lectins, C-Type; D008565:Membrane Proteins; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; C085567:complement C3a receptor
keywords: Anaphylatoxins; Complement; Experimental autoimmune uveoretinitis
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