title: A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats.
abstract: OBJECTIVE
  The purpose of this systematic review is to summarize the results of studies which have determined the minimum alveolar concentration (MAC) of isoflurane and sevoflurane in domestic cats.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Cats.
  
  
  METHODS
  A comprehensive search of research literature was performed without language restriction. The search utilized the Pubmed, Google Scholar, and CAB Abstracts electronic databases using a combination of free text terms 'Minimum alveolar concentration', 'sevoflurane', 'isoflurane', 'anesthetic', 'cat', 'cats' or 'feline'. The search was conducted from November 2010 to June 2012.
  
  
  RESULTS
  The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± 0.33%. The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%.
  
  
  CONCLUSIONS
  The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. Methodology differed among studies, and particular attention should be paid in the future to appropriate reporting of methods to allow sound conclusions to be made from the results.
authors.affiliation: Veterinary Teaching Hospital, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: Mike R
authors.initials: MR
authors.lastname: Shaughnessy
authors.forename: Erik H
authors.initials: EH
authors.lastname: Hofmeister
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D000818:Animals; D002415:Cats; D007530:Isoflurane / Q000493:pharmacokinetics*; D008738:Methyl Ethers / Q000493:pharmacokinetics*; D011650:Pulmonary Alveoli; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane
keywords: cats; isoflurane; minimum alveolar concentration; sevoflurane; stimulation