title: [Sub-acute thyroiditis in a patient on immunosuppressive treatment].
abstract: Sub-acute thyroiditis or De Quervain's thyroiditis is a viral, inflammatory disease which causes the serum release of thyroidal hormones and hyperthyroidism. The pathogenesis of thyroid follicle damage is unclear because the exclusive viral action or a concomitant autoimmune component, determined by the lymphoid infiltrate remain to be assessed. We describe the case of a patient under immunosuppressive treatment, who developed sub-acute thyroiditis with hormone release and hyperthyroidism. The patient, while was under immunosuppressive treatment for kidney transplant, exhibited a clinical picture and hormonal profile of hyperthyroidism. Thyroid scintiscan exhibited an extremely low uptake. Fine-needle cytologic diagnosis was granulomatous sub-acute thyroiditis (De Quervain's thyroiditis). This case suggests the primary or even exclusive role of the viral infection in hormone release and hyperthyroidism in sub-acute thyroiditis, excluding an autoimmune component.
authors.forename: Giovanna
authors.initials: G
authors.lastname: D'Amico
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Crescenzo
authors.forename: Alessia
authors.initials: A
authors.lastname: Caleo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Garzi
authors.forename: Mario
authors.initials: M
authors.lastname: Vitale
mesh_terms: D044963:Biopsy, Fine-Needle; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000209:etiology; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis; D013968:Thyroiditis, Subacute / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D014463:Ultrasonography; D015431:Weight Loss
chemical_list: D007166:Immunosuppressive Agents; D013963:Thyroid Hormones; D016572:Cyclosporine; D011241:Prednisone