title: Equivalent neural responses in children and adolescents with and without autism during judgments of affect.
abstract: Previous research has noted disrupted patterns of neural activation during emotion, processing in individuals with autism spectrum disorders (ASD). However, prior research relied on, designs that may place greater cognitive load on individuals with ASD. In order to address this issue, we adapted the fMRI task of Ochsner et al. (2004a) for children by, presenting fewer stimuli, with fewer valence levels, and longer stimuli duration. A localizer sample of, typically developing children (n=26) was used to construct regions of interest involved in emotional, processing. Activations in these regions during self- and other-referential emotion processing was, compared in age, IQ, gender matched groups (n=17 ASD, n=16 TD). Matched samples replicate, condition contrasts of the localizer, but no group differences were found in behavior measures or, neural activation. An exploratory functional connectivity analysis in a subset of the matched groups, also did not detect striking differences between the groups. These findings suggest that disruptions in activation in emotion processing neural networks in ASD is partially a function of task related cognitive load.
authors.affiliation: Yale University, 230 South Frontage Road, New Haven, CT 06520, USA. Electronic address: brent.vanderwyk@yale.edu.
authors.forename: Brent C
authors.initials: BC
authors.lastname: Vander Wyk
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, P.O. Box 500355, 04303 Leipzig, Germany.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Hoffman
authors.affiliation: Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Pelphrey
mesh_terms: D000293:Adolescent; D000339:Affect; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D007360:Intelligence; D007600:Judgment; D008279:Magnetic Resonance Imaging; D008297:Male; D011930:Reaction Time
keywords: Autism; Connectivity; Emotion; Self-referential processing; fMRI
references.citation: J Autism Dev Disord. 2007 Apr;37(4):613-27
references.pmid: 17180459
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4259-64
references.pmid: 11259662
references.citation: Psychol Sci. 2003 Mar;14(2):151-7
references.pmid: 12661677
references.citation: Trends Cogn Sci. 2007 Apr;11(4):153-7
references.pmid: 17300981
references.citation: Nature. 2009 May 14;459(7244):257-61
references.pmid: 19329996
references.citation: Neuroimage. 2004 Oct;23(2):483-99
references.pmid: 15488398
references.citation: Neuroimage. 1996 Aug;4(1):16-33
references.pmid: 9345494
references.citation: Child Neuropsychol. 2008 Sep;14(5):419-37
references.pmid: 18720100
references.citation: Neuroimage. 2006 May 15;31(1):440-57
references.pmid: 16466680
references.citation: Cogn Emot. 2013;27(6):1042-61
references.pmid: 23387530
references.citation: Child Neuropsychol. 2010;16(3):255-78
references.pmid: 20301009
references.citation: Neuroimage. 2005 Dec;28(4):757-62
references.pmid: 16325141
references.citation: J Am Acad Child Adolesc Psychiatry. 2004 Apr;43(4):481-90
references.pmid: 15187809
references.citation: Neuroimage. 2007 Mar;35(1):430-40
references.pmid: 17239620
references.citation: Emotion. 2008 Dec;8(6):803-9
references.pmid: 19102591
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: Trends Cogn Sci. 2006 Jun;10(6):258-64
references.pmid: 16713326
references.citation: J Cogn Neurosci. 2004 Dec;16(10):1746-72
references.pmid: 15701226
references.citation: J Autism Dev Disord. 2004 Apr;34(2):163-75
references.pmid: 15162935
references.citation: J Autism Dev Disord. 2000 Jun;30(3):205-23
references.pmid: 11055457
references.citation: J Child Psychol Psychiatry. 2000 Mar;41(3):369-79
references.pmid: 10784084
references.citation: J Autism Dev Disord. 2008 Mar;38(3):464-73
references.pmid: 17990089
references.citation: Neuron. 2006 May 18;50(4):655-63
references.pmid: 16701214
references.citation: Hum Brain Mapp. 2000 Jul;10(3):120-31
references.pmid: 10912591
references.citation: Psychol Rev. 2009 Jan;116(1):252-82
references.pmid: 19159156
references.citation: Soc Neurosci. 2011;6(1):1-21
references.pmid: 20945256
references.citation: Neurosci Biobehav Rev. 2012 Mar;36(3):1060-84
references.pmid: 22212588
references.citation: J Autism Dev Disord. 2003 Aug;33(4):427-33
references.pmid: 12959421
references.citation: J Am Acad Child Adolesc Psychiatry. 2004 Apr;43(4):473-80
references.pmid: 15187808
references.citation: J Neurosci. 1996 Jul 1;16(13):4207-21
references.pmid: 8753882
references.citation: Psychol Med. 2006 Dec;36(12):1789-98
references.pmid: 17018169
references.citation: J Autism Dev Disord. 2009 Dec;39(12):1663-72
references.pmid: 19590943
references.citation: J Cogn Neurosci. 2005 Aug;17(8):1306-15
references.pmid: 16197685
references.citation: Neuropsychologia. 2009 Dec;47(14):3275-8
references.pmid: 19632248
references.citation: Neuropsychol Rev. 2010 Sep;20(3):290-322
references.pmid: 20809200
references.citation: Monogr Soc Res Child Dev. 2006;71(2):vii-166
references.pmid: 17177915
references.citation: Soc Cogn Affect Neurosci. 2006 Jun;1(1):18-25
references.pmid: 18985097
references.citation: Neuroimage. 2010 Jan 1;49(1):1055-65
references.pmid: 19647799
references.citation: Neuroimage. 2010 Apr 15;50(3):1027-35
references.pmid: 20060479
references.citation: Hum Brain Mapp. 1997;5(4):238-42
references.pmid: 20408222
references.citation: J Autism Dev Disord. 1994 Oct;24(5):659-85
references.pmid: 7814313
references.citation: J Autism Dev Disord. 2013 Feb;43(2):272-85
references.pmid: 22760337
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21223-8
references.pmid: 21078973
references.citation: Emotion. 2003 Dec;3(4):394-400
references.pmid: 14674831
references.citation: Soc Neurosci. 2008;3(2):97-112
references.pmid: 18633852
references.citation: Neuroimage. 2012 Feb 1;59(3):2142-54
references.pmid: 22019881
references.citation: Biol Psychiatry. 2008 Mar 15;63(6):577-86
references.pmid: 17888411
references.citation: Brain. 2010 Feb;133(Pt 2):611-24
references.pmid: 20008375
references.citation: Arch Gen Psychiatry. 2002 Sep;59(9):809-16
references.pmid: 12215080
references.citation: Neuroimage. 2005 Oct 15;28(1):249-55
references.pmid: 15993624
references.citation: J Autism Dev Disord. 2004 Apr;34(2):229-35
references.pmid: 15162941