title: Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in Calabar and Uyo cities, Nigeria.
abstract: OBJECTIVE
  The angiotensin II protein is a vasoconstrictor that exerts most of its influence through the angiotensin II type 1 receptor (AT1R). Inconsistent association between the A1166C polymorphism of the AT1R gene and hypertension has been reported among various populations but not among the peoples of Calabar and Uyo. This study was designed to determine the frequency of the A1166C polymorphism of the AT1R gene and its association with hypertension in a sample population of Calabar and Uyo.
  
  
  METHODS
  A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls were randomly recruited from hypertension clinics and the general population. Genotyping of the A1166C allele of the AT1R gene to identify variants was performed using polymerase chain reaction and restriction enzyme digestion. Multiple regressions were applied to test whether the A1166 genotypes were predictors of hypertension.
  
  
  RESULTS
  99% of the study population had the wild type AA genotype, and 1% was AC heterozygous carriers of the A1166C polymorphism.
  
  
  CONCLUSIONS
  The A1166C polymorphism was not a predictor of hypertension in the sample population of Calabar and Uyo.
authors.affiliation: Department of Genetics and Biotechnology, University of Calabar, Nigeria.
authors.forename: Mary Esien
authors.initials: ME
authors.lastname: Kooffreh
authors.forename: Chiaka Ijeoma
authors.initials: CI
authors.lastname: Anumudu
authors.forename: Roseline
authors.initials: R
authors.lastname: Duke
authors.forename: Elza Cletus
authors.initials: EC
authors.lastname: Okpako
authors.forename: P Lava
authors.initials: PL
authors.lastname: Kumar
keywords: A1166C; hypertension; polymorphism
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