title: Long non-coding RNAs and complex human diseases.
abstract: Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.
authors.affiliation: Bioinformatics Research Group, Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China. zhenyu.xuan@utdallas.edu.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Xuan
authors.forename: Changning
authors.initials: C
authors.lastname: Liu
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009422:Nervous System Diseases / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
references.citation: Behav Brain Res. 2004 Sep 23;154(1):273-89
references.pmid: 15302134
references.citation: J Biol Chem. 2005 Jun 24;280(25):24159-67
references.pmid: 15855153
references.citation: Carcinogenesis. 2009 Mar;30(3):544-5; author reply 546
references.pmid: 19126653
references.citation: RNA. 2011 May;17(5):878-91
references.pmid: 21460236
references.citation: RNA. 2007 Apr;13(4):583-96
references.pmid: 17307818
references.citation: Mol Cell. 2011 Sep 16;43(6):904-14
references.pmid: 21925379
references.citation: Am J Hum Genet. 2012 Jan 13;90(1):7-24
references.pmid: 22243964
references.citation: Mol Cell. 2010 Jun 11;38(5):662-74
references.pmid: 20541999
references.citation: Cancer Res. 1999 Dec 1;59(23):5975-9
references.pmid: 10606244
references.citation: Science. 2008 Dec 12;322(5908):1717-20
references.pmid: 18988810
references.citation: Trends Genet. 2002 Feb;18(2):63-5
references.pmid: 11818131
references.citation: Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10679-84
references.pmid: 17553964
references.citation: Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32
references.pmid: 15738415
references.citation: Genes Dev. 2011 Sep 15;25(18):1915-27
references.pmid: 21890647
references.citation: Carcinogenesis. 2004 Nov;25(11):2125-33
references.pmid: 15240511
references.citation: Cancer Sci. 2008 Jun;99(6):1092-9
references.pmid: 18482052
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72
references.pmid: 19571010
references.citation: Trends Genet. 2006 Jan;22(1):1-5
references.pmid: 16290135
references.citation: Nat Med. 2008 Jul;14(7):723-30
references.pmid: 18587408
references.citation: FEBS J. 2012 Sep;279(17):3159-65
references.pmid: 22776265
references.citation: Science. 2005 Sep 2;309(5740):1564-6
references.pmid: 16141073
references.citation: Mol Biosyst. 2012 Sep;8(9):2289-94
references.pmid: 22722759
references.citation: FASEB J. 2011 Feb;25(2):444-8
references.pmid: 20956613
references.citation: Cancer Res. 2009 Jan 15;69(2):625-31
references.pmid: 19147577
references.citation: Science. 2007 Jun 8;316(5830):1488-91
references.pmid: 17478681
references.citation: Cell. 2010 Aug 6;142(3):409-19
references.pmid: 20673990
references.citation: Hum Mol Genet. 2000 Jun 12;9(10):1543-51
references.pmid: 10888605
references.citation: Nucleic Acids Res. 1995 May 25;23(10):1758-65
references.pmid: 7784180
references.citation: Nature. 2002 Dec 5;420(6915):563-73
references.pmid: 12466851
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):716-21
references.pmid: 18184812
references.citation: Mol Cancer. 2011 Nov 13;10:141
references.pmid: 22078386
references.citation: Nature. 2010 Jun 24;465(7301):1033-8
references.pmid: 20577206
references.citation: Cell. 2010 Oct 1;143(1):46-58
references.pmid: 20887892
references.citation: Science. 2007 Jun 8;316(5830):1484-8
references.pmid: 17510325
references.citation: Nat Struct Mol Biol. 2010 Jul;17(7):862-8
references.pmid: 20543829
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D146-51
references.pmid: 21112873
references.citation: Curr Opin Cell Biol. 2009 Jun;21(3):359-66
references.pmid: 19477626
references.citation: Int J Oncol. 2011 Jul;39(1):169-75
references.pmid: 21503572
references.citation: Nat Genet. 2009 Aug;41(8):899-904
references.pmid: 19578367
references.citation: Nucleic Acids Res. 2011 May;39(9):3864-78
references.pmid: 21247874
references.citation: Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1671-7
references.pmid: 19592466
references.citation: Cancer Cell. 2007 Sep;12(3):215-29
references.pmid: 17785203
references.citation: Gastroenterology. 2007 Jan;132(1):330-42
references.pmid: 17241883
references.citation: Oncology. 2001;60(3):268-73
references.pmid: 11340379
references.citation: Nat Genet. 2006 Jul;38(7):758-69
references.pmid: 16804541
references.citation: Nature. 2004 Oct 14;431(7010):1 p following 757; discussion following 757
references.pmid: 15495343
references.citation: Science. 2007 Aug 17;317(5840):915
references.pmid: 17702936
references.citation: Science. 2004 May 28;304(5675):1321-5
references.pmid: 15131266
references.citation: Nucleic Acids Res. 2011 Apr;39(7):2649-57
references.pmid: 21131283
references.citation: Cancer Res. 2011 Oct 15;71(20):6320-6
references.pmid: 21862635
references.citation: Nucleic Acids Res. 2005 Jan 1;33(Database issue):D112-5
references.pmid: 15608158
references.citation: Breast Cancer Res Treat. 2012 Dec;136(3):875-83
references.pmid: 23124417
references.citation: FASEB J. 2010 Oct;24(10):4033-46
references.pmid: 20581224
references.citation: PLoS Genet. 2012;8(7):e1002841
references.pmid: 22844254
references.citation: N Engl J Med. 2007 Aug 2;357(5):443-53
references.pmid: 17634449
references.citation: Mol Cell. 2008 Feb 29;29(4):499-509
references.pmid: 18313387
references.citation: Bioessays. 2010 Jun;32(6):473-80
references.pmid: 20486133
references.citation: Clin Cancer Res. 2006 Aug 15;12(16):4851-8
references.pmid: 16914571
references.citation: Oncol Rep. 2013 Mar;29(3):946-50
references.pmid: 23292722
references.citation: Cancer Res. 2010 Mar 15;70(6):2350-8
references.pmid: 20179190
references.citation: Science. 2004 Dec 24;306(5705):2242-6
references.pmid: 15539566
references.citation: Nat Clin Pract Neurol. 2007 Feb;3(2):107-12
references.pmid: 17279084
references.citation: Lancet Neurol. 2007 Jan;6(1):45-55
references.pmid: 17166801
references.citation: J Hum Genet. 2006;51(12):1087-1099
references.pmid: 17066261
references.citation: Mol Biosyst. 2013 Mar;9(3):407-11
references.pmid: 23295831
references.citation: Trends Genet. 2008 Jul;24(7):323-7
references.pmid: 18514357
references.citation: Science. 2005 Sep 2;309(5740):1559-63
references.pmid: 16141072
references.citation: Nat Rev Genet. 2005 Apr;6(4):287-98
references.pmid: 15803198
references.citation: Science. 2006 Jul 21;313(5785):363-7
references.pmid: 16778019
references.citation: Cell. 2007 Jun 29;129(7):1311-23
references.pmid: 17604720
references.citation: Cancer Lett. 2013 Jun 10;333(2):213-21
references.pmid: 23354591
references.citation: Nature. 2010 Apr 15;464(7291):1071-6
references.pmid: 20393566
references.citation: Cancer Res. 2002 May 1;62(9):2695-8
references.pmid: 11980670
references.citation: J Pathol. 1997 Nov;183(3):345-51
references.pmid: 9422992
references.citation: BMC Genomics. 2008 May 21;9:236
references.pmid: 18492288
references.citation: Nucl Recept Signal. 2007 Aug 03;5:e006
references.pmid: 17710122
references.citation: Oncogene. 2011 Nov 24;30(47):4750-6
references.pmid: 21625215
references.citation: J Biol Chem. 2007 Aug 24;282(34):24731-42
references.pmid: 17569660
references.citation: FEBS Lett. 2008 Jun 11;582(13):1919-27
references.pmid: 18501714
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D210-5
references.pmid: 22135294
references.citation: Int J Cancer. 2006 Feb 15;118(4):1054-9
references.pmid: 16152589
references.citation: Endocrinology. 2010 Mar;151(3):939-47
references.pmid: 20032057
references.citation: Cancer Res. 2010 Jan 1;70(1):160-71
references.pmid: 20048075
references.citation: Cancer Res. 2011 Jun 1;71(11):3852-62
references.pmid: 21558391
references.citation: Nat Genet. 2003 Jun;34(2):157-65
references.pmid: 12730694
references.citation: Nature. 2012 Sep 6;489(7414):57-74
references.pmid: 22955616
references.citation: RNA. 2007 Jun;13(6):890-8
references.pmid: 17416635
references.citation: Curr Alzheimer Res. 2012 Feb;9(2):178-83
references.pmid: 22455478
references.citation: Hum Mol Genet. 2008 Mar 15;17(6):806-14
references.pmid: 18048406
references.citation: Int J Oncol. 2009 Apr;34(4):931-8
references.pmid: 19287950
references.citation: Science. 1994 Jul 15;265(5170):346-55
references.pmid: 8023157
references.citation: Neurobiol Aging. 1998 May-Jun;19(3):173-89
references.pmid: 9661992
references.citation: Curr Issues Mol Biol. 2008;10(1-2):25-36
references.pmid: 18525104
references.citation: Tumour Biol. 2013 Apr;34(2):613-20
references.pmid: 23359273
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D89-92
references.pmid: 18948287
references.citation: Nat Rev Mol Cell Biol. 2013 Jan;14(1):4-5
references.pmid: 23212473
references.citation: Cell. 2011 Aug 5;146(3):353-8
references.pmid: 21802130
references.citation: RNA Biol. 2009 Apr-Jun;6(2):94-9
references.pmid: 19246991
references.citation: Nature. 2009 Sep 10;461(7261):230-5
references.pmid: 19701182
references.citation: Science. 2005 Sep 2;309(5740):1570-3
references.pmid: 16141075
references.citation: Nat Genet. 2010 May;42(5):420-5
references.pmid: 20364137
references.citation: Nat Genet. 2009 Aug;41(8):909-14
references.pmid: 19578363
references.citation: Eur J Gastroenterol Hepatol. 2009 Jun;21(6):688-92
references.pmid: 19445043
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D246-51
references.pmid: 23042674
references.citation: Nature. 2010 Mar 18;464(7287):409-12
references.pmid: 20173736
references.citation: Genomics. 2009 Apr;93(4):291-8
references.pmid: 19071207
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D177-87
references.pmid: 23161675
references.citation: PLoS One. 2008 Jan 23;3(1):e1486
references.pmid: 18213394
references.citation: Science. 2008 Dec 19;322(5909):1851-4
references.pmid: 19056938
references.citation: Science. 2010 Aug 6;329(5992):689-93
references.pmid: 20616235
references.citation: BMC Bioinformatics. 2007 Aug 30;8:319
references.pmid: 17760969
references.citation: Neurobiol Dis. 2009 Oct;36(1):26-34
references.pmid: 19591933
references.citation: Cell. 2009 Feb 20;136(4):629-41
references.pmid: 19239885
references.citation: Genomics. 2010 Jun;95(6):355-62
references.pmid: 20214974
references.citation: Nature. 2001 Feb 15;409(6822):860-921
references.pmid: 11237011
references.citation: Mol Cell. 2010 Sep 24;39(6):925-38
references.pmid: 20797886
references.citation: Cancer Sci. 2011 Jan;102(1):245-52
references.pmid: 20874843
references.citation: Nature. 2010 May 13;465(7295):182-7
references.pmid: 20393465
references.citation: J Clin Endocrinol Metab. 2003 Nov;88(11):5119-26
references.pmid: 14602737
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D122-6
references.pmid: 18829717
references.citation: Hum Mol Genet. 2007 Dec 15;16(24):3174-87
references.pmid: 17921506
references.citation: PLoS One. 2007 Sep 05;2(9):e845
references.pmid: 17786216
references.citation: J Natl Cancer Inst. 1999 Jan 20;91(2):143-51
references.pmid: 9923855
references.citation: Neurochem Int. 1997 Sep;31(3):379-92
references.pmid: 9246680
references.citation: Nature. 2009 Mar 12;458(7235):223-7
references.pmid: 19182780
references.citation: Nature. 2006 Sep 14;443(7108):167-72
references.pmid: 16915236
references.citation: Genes Dev. 2009 Jul 1;23(13):1494-504
references.pmid: 19571179
references.citation: Hum Mol Genet. 2004 Oct 1;13(19):2221-31
references.pmid: 15294872
references.citation: Genes Cells. 2000 Mar;5(3):211-20
references.pmid: 10759892
references.citation: Am J Hum Genet. 2007 Apr;80(4):692-704
references.pmid: 17357075
references.citation: Breast Cancer Res. 2003;5(6):R223-30
references.pmid: 14580258
references.citation: Gene. 2012 Mar 15;496(1):8-16
references.pmid: 22285928
references.citation: Oncogene. 2009 Jan 15;28(2):195-208
references.pmid: 18836484
references.citation: Oncogene. 2003 Sep 11;22(39):8031-41
references.pmid: 12970751
references.citation: Oncogene. 2004 Jan 15;23(2):605-11
references.pmid: 14724589
references.citation: BMC Cancer. 2009 Dec 15;9:441
references.pmid: 20003513
references.citation: Urology. 2011 Feb;77(2):510.e1-5
references.pmid: 21147498
references.citation: Mol Cell Biol. 1990 Jan;10(1):28-36
references.pmid: 1688465
references.citation: Genetics. 2013 Mar;193(3):651-69
references.pmid: 23463798
references.citation: Curr Opin Struct Biol. 2003 Jun;13(3):300-8
references.pmid: 12831880
references.citation: FEBS Lett. 2010 Nov 19;584(22):4575-80
references.pmid: 20937273
references.citation: Nat Struct Mol Biol. 2013 Mar;20(3):300-7
references.pmid: 23463315
references.citation: Nature. 2011 Aug 28;477(7364):295-300
references.pmid: 21874018
references.citation: Nat Genet. 2010 Jun;42(6):504-7
references.pmid: 20453838