title: [Preliminary experience with assessing the motor pathways and central inhibition in patients with malignant cerebral gliomas in preparation for conformal radiotherapy].
abstract: We investigated central motor pathways and central inhibition in patients with brain gliomas by transcranial magnetic stimulation (TMS). 10 glioma patients and 16 matching controls were enrolled. Central motor conduction time, MEP latencies and amplitudes and silent period were evaluated. In 90% glioma patients TMS parameters were abnormal, mostly MEP shapes and thresholds were affected. In 40% of the cases central inhibition in glioma affected hemisphere was abnormally high. We propose that TMS is safe and informative tool in glioma patients; central inhibition seems to be affected in some cases by the glioma presence in the hemisphere. One of the possible causes of that may be GABA system activation.
authors.forename: A V
authors.initials: AV
authors.lastname: Kartashev
authors.forename: V M
authors.initials: VM
authors.lastname: Vinogradov
authors.forename: V B
authors.initials: VB
authors.lastname: Voĭtenkov
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000378:metabolism / Q000503:physiopathology* / Q000532:radiotherapy*; D004525:Efferent Pathways / Q000503:physiopathology* / Q000528:radiation effects; D019054:Evoked Potentials, Motor; D005260:Female; D018682:GABA Agents / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000503:physiopathology* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000378:metabolism / Q000503:physiopathology*; D020266:Radiotherapy, Conformal; D050781:Transcranial Magnetic Stimulation
chemical_list: D018682:GABA Agents