title: Association of chronic obstructive pulmonary disease with coronary artery disease.
abstract: BACKGROUND
  The relationship between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) remains largely unknown. This study aimed to explore the association of COPD with CAD, especially with multi-vessel disease (VD).
  
  
  METHODS
  The data of 354 patients who underwent multi-detector computed tomography (MDCT) for suspected CAD were analyzed. Luminal narrowing was defined as at least one lesion 50% or greater stenosis. The analysis of serum biochemistry profile and spirometry were performed on all eligible patients, and the diagnosis of COPD was defined as the criteria of Global Initiative for Chronic Obstructive Lung Disease.
  
  
  RESULTS
  Patients with CAD had a significantly higher complication of COPD than those without CAD (11.8% vs. 3.7%, P < 0.001). Comparing with patients without COPD, those with COPD were more likely to have multi-VD, proportion of smoking and high C-reactive protein (CRP) (P < 0.001). Multivariate Logistic regression analysis revealed that the multi-VD was significantly correlated with COPD (P=0.012) and CRP (P=0.015).
  
  
  CONCLUSIONS
  There was a high complication of COPD in patients with CAD, and COPD may be a critical risk factor for CAD, especially for multi-VD. CAD and COPD were closely associated and the interplay of systemic inflammation might in part explain the relationship between them.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Bin-Miao
authors.initials: BM
authors.lastname: Liang
authors.forename: Zhi-Bo
authors.initials: ZB
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Yi
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Ou
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000000981:diagnostic imaging* / Q000378:metabolism; D011859:Radiography; D012307:Risk Factors