title: Enhanced detection of high-mass proteins by using an active pixel detector.
abstract: Flying high: Application of an active pixel detector with high charge sensitivity to a linear time-of-flight mass spectrometer results in enhanced detection of high-mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass-dependent ion-focusing phenomena.
authors.affiliation: Biomolecular Imaging Mass Spectrometry, FOM Institute AMOLF, Science Park 104, 1098 XG Amsterdam (The Netherlands).
authors.forename: Shane R
authors.initials: SR
authors.lastname: Ellis
authors.forename: Julia H
authors.initials: JH
authors.lastname: Jungmann
authors.forename: Donald F
authors.initials: DF
authors.lastname: Smith
authors.forename: Jens
authors.initials: J
authors.lastname: Soltwisch
authors.forename: Ron M A
authors.initials: RM
authors.lastname: Heeren
mesh_terms: D008970:Molecular Weight; D011506:Proteins; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D011506:Proteins
keywords: MALDI; high-mass detection; mass spectrometry; microchannel plate; proteins