title: Influence of age on short-term complications after intraoperative radiotherapy in women after breast-conserving surgery.
abstract: BACKGROUND
  We investigated the influence of age on short-term complications in women undergoing intraoperative radiotherapy (IORT) for early breast cancer.
  
  
  METHODS
  We retrospectively analyzed data of 188 women who underwent IORT during breast-conserving surgery (BCS). The study group consisted of 54 patients aged 70 years or older. One hundred and thirty four patients aged less than 70 years served as the control group.
  
  
  RESULTS
  In both collectives, the acute toxicity was low. There were no significant differences regarding type and duration of surgery, and type of radiation treatment, comparing both collectives. The most frequent postoperative side-effects were haematoma/suggillation (13/54, 24.1% vs. 28/134, 20.9%; p=0.633). There was a significantly higher incidence of postoperative axillary haematoma in the study group (10/54, 18.5% vs. 10/134, 7.5%; p=0.026).
  
  
  CONCLUSIONS
  Acute toxicity after BCS with IORT in women aged 70 years and older does not seem to be higher compared to younger patients.
authors.affiliation: Department of Gynaecology and Obstetrics, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. benjamin.tuschy@umm.de.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Tuschy
authors.forename: Sebastian
authors.initials: S
authors.lastname: Berlit
authors.forename: Simone
authors.initials: S
authors.lastname: Romero
authors.forename: Elena
authors.initials: E
authors.lastname: Sperk
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
authors.forename: Sven
authors.initials: S
authors.lastname: Kehl
authors.forename: Marc
authors.initials: M
authors.lastname: Sütterlin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D015412:Mastectomy, Segmental / Q000379:methods*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies
keywords: IORT; breast cancer; elderly; morbidity; short-term outcome