title: Aortic stiffness and left ventricular diastolic function in children following early repair of aortic coarctation.
abstract: Aortic stiffness and diastolic function are abnormal in adults with repaired coarctation of the aorta (CoA). The goal of this study was to determine the relation between aortic stiffness and left ventricular (LV) diastolic impairment in children who had undergone CoA repair very early in life. This is a retrospective review of echocardiograms in children with isolated repaired CoA (group CoA; n = 24) and healthy matched controls (group Normal; n = 24). We analyzed systolic and LV diastolic functions, proximal and distal ascending aortic stiffness indices (SIs), distensibility, and strain. Age range was 0.3 to 21 (median 9) years. Age at time of CoA repair was 0 to 24 (median 0.5) months. Median time since CoA repair was 6 years. There was no significant difference in blood pressure, LV size, and systolic function between the groups. LV diastolic function was impaired in group CoA compared with group Normal (septal E': CoA 10.3 ± 1.6 cm/s and Normal 13.4 ± 1.9 cm/s, p <0.001). All parameters of proximal and distal ascending aortic elasticities were abnormal in group CoA versus Normal (SI of proximal ascending aorta: CoA 4.9 ± 1.6 and Normal 2.7 ± 0.6, p <0.001). Across all patients, there was a strong correlation between septal E' and proximal ascending aortic SI (r = -0.72, p <0.001). In conclusion, even children who underwent CoA repair at a very young age have abnormal LV diastolic function and aortic elasticity compared with controls and there is a linear relation between the 2. LV diastolic dysfunction in patients with repaired CoA may be due to chronically increased afterload.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Kristin C
authors.initials: KC
authors.lastname: Lombardi
authors.forename: Veronika
authors.initials: V
authors.lastname: Northrup
authors.forename: Robert L
authors.initials: RL
authors.lastname: McNamara
authors.forename: Lissa
authors.initials: L
authors.lastname: Sugeng
authors.forename: Constance G
authors.initials: CG
authors.lastname: Weismann
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001017:Aortic Coarctation / Q000150:complications / Q000601:surgery*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D059289:Vascular Stiffness / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D016277:Ventricular Function, Left; D055815:Young Adult