title: Small molecule PET-radiopharmaceuticals.
abstract: This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in (11)C and (18)F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.
authors.forename: Philip H
authors.initials: PH
authors.lastname: Elsinga
authors.affiliation: University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium. p.h.elsinga@umcg.nl.
authors.forename: Rudi A J O
authors.initials: RA
authors.lastname: Dierckx
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods* / Q000639:trends; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18