title: Renal impairment during the treatment of telaprevir with peginterferon and ribavirin in patients with chronic hepatitis C.
abstract: OBJECTIVE
  Renal damage has been reported as an important complication during combination treatment of peginterferon (PEG IFN), ribavirin (RBV) and telaprevir (TVR) for chronic hepatitis C. However, very little is known about this complication. We investigated the role TVR plays in renal damage during this triple therapy.
  
  
  METHODS
  Twenty-five chronic hepatitis C patients with genotype 1 and high viral load received TVR in combination with PEG IFN and RBV for 12 weeks followed by treatment with PEG IFN and RBV. Renal function of these patients was prospectively evaluated for 16 weeks.
  
  
  RESULTS
  Creatinine clearance decreased significantly during PEG IFN/RBV/TVR treatment. Consequently, serum creatinine and cystatin C significantly rose during PEG IFN/RBV/TVR treatment. Serum creatinine returned to pretreatment levels after the termination of TVR. The increase of serum creatinine and cystatin C from baseline significantly correlated with serum TVR level at day 7, which was determined by starting dose of TVR per bodyweight . When the patients were classified according to the starting dose of TVR per bodyweight, renal impairment was observed only in the high-dose (TVR ≥33 mg/kg per day) group, not in the low-dose (TVR <33 mg/kg per day) group.
  
  
  CONCLUSIONS
  These results suggest that TVR dose per bodyweight is important for the occurrence of renal impairment in PEG IFN/RBV/TVR treatment.
authors.affiliation: Department of Gastroenterology, Ikeda Municipal Hospital, Ikeda, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Fukuda
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Imai
authors.forename: Naoki
authors.initials: N
authors.lastname: Hiramatsu
authors.forename: Keiko
authors.initials: K
authors.lastname: Irishio
authors.forename: Takumi
authors.initials: T
authors.lastname: Igura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sawai
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Kogita
authors.forename: Yuki
authors.initials: Y
authors.lastname: Makino
authors.forename: Rui
authors.initials: R
authors.lastname: Mizumoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakahara
authors.forename: Sinichiro
authors.initials: S
authors.lastname: Zushi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kajiwara
authors.forename: Tsugiko
authors.initials: T
authors.lastname: Oze
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.forename: Norio
authors.initials: N
authors.lastname: Hayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takehara
keywords: chronic hepatitis C; peginterferon; renal impairment; ribavirin; telaprevir