title: Host restriction factor screening: let the virus do the work.
abstract: In this issue of Cell Host & Microbe, Varble et al. (2013) engineer a library of RNA viruses to express small interfering RNAs and couple this with the power of virus evolution and selection to screen for host genes that when silenced resulted in greater viral infection in vivo.
authors.affiliation: Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St. Louis, MO 63110, USA. Electronic address: diamond@borcim.wustl.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
authors.forename: John W
authors.initials: JW
authors.lastname: Schoggins
mesh_terms: D000818:Animals; D005820:Genetic Testing / Q000379:methods*; D054884:Host-Pathogen Interactions; D006801:Humans; D012845:Sindbis Virus / Q000276:immunology* / Q000502:physiology*; D014779:Virus Replication
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