title: Metabolites from intestinal microbes shape Treg.
abstract: Intestinal bacterial metabolites are an important communication tool between the host immune system and the commensal microbiota to establish mutualism. In a recent paper published in Science, Wendy Garrett and her colleagues report an exciting role of the three most abundant microbial-derived short-chain fatty acids (SCFA), acetic acid, propionic acid and butyric acid, in colonic regulatory T cell (cTreg) homeostasis.
authors.affiliation: University of Bern, Maurice Müller Laboratories (DKF), University Clinic for Visceral Surgery and Medicine, Murtenstrasse 35, CH-3010 Bern, Switzerland.
authors.forename: Markus B
authors.initials: MB
authors.lastname: Geuking
authors.forename: Kathy D
authors.initials: KD
authors.lastname: McCoy
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Macpherson
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D003106:Colon / Q000382:microbiology*; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D054892:Metagenome; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D005232:Fatty Acids, Volatile
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