title: [Relation of IL-17 polymorphisms and serum levels in patients with chronic HCV infection].
abstract: OBJECTIVE
  To investigate the association of single nucleotide polymorphisms (SNPs) in the interleukin 17 (IL-17) gene and serum protein levels in patients with chronic hepatitis C virus (HCV) infection.
  
  
  METHODS
  A total of 228 patients with chronic HCV infection and 81 healthy controls were enrolled in the study. The frequencies of IL-17 rs8193036 and rs2275913 polymorphisms were detected by the TaqMan SNP genotyping assay. Serum levels of IL-17 protein were detected by ELISA. Pairwise comparisons were made by the Chi-square test, and the significance of between-group differences was assessed by the Student's t-test with P less than 0.05.
  
  
  RESULTS
  The patients with chronic HCV infection and the healthy controls showed similar frequencies of the rs8193036 C/T allele (x2 = 1.428, P = 0.232) and the rs2275913 A/G allele (x2 = 0.106, P = 0.744). In addition, the two groups showed similar distribution of the rs8193036 CC (chronic HCV infection: 46.49% vs. healthy controls: 41.98%), CT (45.61% vs. 44.44%) and TT (7.89% vs. 13.58%) genotypes (x2 = 2.346, P = 0.309), and of the rs2275913 AA (16.23% vs. 13.58%), AG (48.25% vs. 50.62%) and GG (35.53% vs. 35.80%) genotypes (x2 = 0.340, P = 0.844). Subgroup analysis of chronic HCV infection patients stratified according to HCV genotypes 1 and 2 showed no differences in the distribution of rs8193036 and rs2275913 alleles (x2 = 1.127, P = 0.288; x2 = 1.088, P = 0.297) and genotypes (x2 = 2.825, P = 0.246; x2 = 0.970, P = 0.616). However, the chronic HCV infection group did show significantly higher levels of serum IL-17 than the controls (97.67+/-39.68 vs. 71.60+/-19.78 pg/ml, t = 2.414, P = 0.033).
  
  
  CONCLUSIONS
  Chronic HCV infection is associated with increased serum IL-17; however, the IL-17 polymorphisms rs8193036 and rs2275913 were not associated with chronic HCV infection susceptibility in this study's Chinese cohort.
authors.affiliation: Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Yue-min
authors.initials: YM
authors.lastname: Nan
authors.forename: Yu-guo
authors.initials: YG
authors.lastname: Zhang
authors.forename: Ling-bo
authors.initials: LB
authors.lastname: Kong
authors.forename: Huan-wei
authors.initials: HW
authors.lastname: Zheng
authors.forename: Dian-xing
authors.initials: DX
authors.lastname: Sun
authors.forename: Chun-mian
authors.initials: CM
authors.lastname: An
authors.forename: You-sheng
authors.initials: YS
authors.lastname: Li
authors.forename: Cang-you
authors.initials: CY
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Kong
authors.forename: Er-hei
authors.initials: EH
authors.lastname: Dai
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Tong
authors.forename: Su-xian
authors.initials: SX
authors.lastname: Zhao
authors.forename: Shan-shan
authors.initials: SS
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000097:blood / Q000235:genetics* / Q000821:virology; D006801:Humans; D020381:Interleukin-17 / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D020381:Interleukin-17