title: Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties.
abstract: 4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the presence of formaldehyde. The synthesis of S-alkylated compounds 8-11 was performed from the reaction of the corresponding triazol-5-thioles with various alkyl halides. The condensation of carbo(thio)amides 2-4 with 4-chlorophenacyl bromide afforded the corresponding 1,3-thia(oxa)zol-2(3H)-ylidene]pyridine-3-carbohydrazides 25-27. 1,3-Thia(oxa)zolidine derivatives 28-30 were obtained from the cyclization reaction between compounds 2-4 and ethyl bromoacetate. All newly synthesized compounds were screened for their antimicrobial, antiurease, and antilipase activities. The biological activity studies revealed that all the compounds screened showed good or moderate antimicrobial, antiurease, and/or antilipase activity.
authors.affiliation: Department of Forest Industrial Engineering, Artvin Çoruh University, Artvin, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Ceylan
authors.forename: Hakan
authors.initials: H
authors.lastname: Bektas
authors.forename: Hacer
authors.initials: H
authors.lastname: Bayrak
authors.forename: Neslihan
authors.initials: N
authors.lastname: Demirbas
authors.forename: Sengul
authors.initials: S
authors.lastname: Alpay-Karaoglu
authors.forename: Serdar
authors.initials: S
authors.lastname: Ulker
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors*; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D008352:Mannich Bases; D014230:Triazoles; C045575:1,2,4-triazole; D008049:Lipase; D014510:Urease
keywords: 1,2,4-Triazole; 1,3-Thia(oxa)zole; 1,3-Thia(oxa)zolidinone; Biological activity; Nicotinic acid hydrazide