title: NIR photothermal therapy using polyaniline nanoparticles.
abstract: Developing a biocompatible and efficient photothermal coupling agent with appropriate size is a prerequisite for the development of near-infrared (NIR) light-induced photothermal therapy (PTT). In the present study, polyaniline nanoparticles (PANPs) with a size of 48.5 ± 1.5 nm were fabricated and exhibited excellent dispersibility in water by a hydrothermal method and further surface functionalization by capping with F127. The developed F127-modified PANPs (F-PANPs) had a high molar extinction coefficient of 8.95 × 10(8) m(-1) cm(-1), and high NIR photothermal conversion efficiency of 48.5%. Furthermore, combined with NIR irradiation at 808 nm and injection of F-PANP samples, in vivo photothermal ablation of tumor with excellent treatment efficacy was achieved. In vitro transmission electron microscopy (TEM) images of cells, methyl thiazolyl tetrazolium (MTT) assay, histology, and hematology studies revealed that the F-PANPs exhibit low toxicity to living systems. Therefore, F-PANPs could be used as PTT agents for ablating cancer, and the concept of developing polyaniline-based nanoparticles can serve as a platform technology for the next generation of in vivo PTT agents.
authors.affiliation: Department of Chemistry, Capital Normal University, No. 105 Xi San Huan Road, Beijing 100048, PR China. Electronic address: Jenniferjingzhou@gmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Lu
authors.forename: Xingjun
authors.initials: X
authors.lastname: Zhu
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liao
authors.forename: Zhanfang
authors.initials: Z
authors.lastname: Ma
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D045325:HCT116 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007259:Infrared Rays; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods
chemical_list: D000814:Aniline Compounds; C416807:polyaniline
keywords: In vivo; Photothermal imaging; Photothermal therapy; Polyaniline nanoparticles