title: Management of upper aerodigestive tract amyloidosis.
abstract: OBJECTIVE
  The aim of this study was to discuss the treatment options for upper aerodigestive tract amyloidosis.
  
  
  METHODS
  Four patients with histologically confirmed amyloidosis were included in the study. All patients underwent surgical treatment. Three patients had laryngeal amyloidosis, and 1 patient had tonsillar amyloidosis.
  
  
  RESULTS
  Two of the cases of laryngeal amyloidosis were successfully treated with a combination of surgery and radiation therapy. One case of laryngeal amyloidosis was treated with surgery alone. The tonsillar amyloidosis was removed by tonsillectomy. None of the cases showed systemic involvement. Long-term follow-up of the patients showed no recurrence or evidence of systemic disease.
  
  
  CONCLUSIONS
  Surgical resection is the primary treatment for patients with upper aerodigestive tract amyloidosis. Radiation therapy is especially effective in cases of recurrent amyloidosis with submucosal involvement. Pedunculated polypoid lesions may be treated with surgery alone, and in cases of recurrence, irradiation following the surgical removal should be considered. Tonsillectomy is usually sufficient for treating tonsillar amyloidosis.
authors.affiliation: Department of Otorhinolaryngology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Celenk
authors.forename: Cengiz
authors.initials: C
authors.lastname: Durucu
authors.forename: Elif
authors.initials: E
authors.lastname: Baysal
authors.forename: Zeynel A
authors.initials: ZA
authors.lastname: Karatas
authors.forename: Mustafa
authors.initials: M
authors.lastname: Polat
authors.forename: Kemal
authors.initials: K
authors.lastname: Bakir
authors.forename: Semih
authors.initials: S
authors.lastname: Mumbuc
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Kanlikama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D010038:Otorhinolaryngologic Diseases / Q000175:diagnosis* / Q000628:therapy*