title: [Clinicopathological characteristics and prognostic factors of 27 patients with rectal gastrointestinal stromal tumors].
abstract: OBJECTIVE
  To explore the clinicopathological characteristics of rectal gastrointestinal stromal tumors (GISTs) and elucidate their associated prognostic factors.
  
  
  METHODS
  The clinicopathological data were collected for 27 patients with rectal gastrointestinal stromal tumors at our hospital from January 2000 to December 2011. Univariate analyses were performed to evaluate the prognostic factors.
  
  
  RESULTS
  Changed habit of discharge and hematochezia were the most common symptoms. Most GISTs were localized in lower rectum. The 1, 3 and 5-year progression-free survival (PFS) rates were 85.19%, 65.04% and 52.04% respectively. Overall survival (OS) and PFS rates were significantly correlated with incisional margin and invasion of surrounding organs. There was no significant difference in PFS and OS between different resection procedures.Due to the limitation of cases multivariate survival analysis can not be performed.
  
  
  CONCLUSIONS
  Incisional margin and invasion of surrounding organs are two important prognostic factors. And transanal excision is both safe and effective for those properly indicated patients.
authors.affiliation: Department of Surgery, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Pei
authors.forename: Dong-bing
authors.initials: DB
authors.lastname: Zhao
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate