title: Infusion of hydroxyethyl starch-containing fluids.
abstract: The infusion of hydroxyethylstarch (HES) containing fluids has been extremely common worldwide over the last decade. Until recently, HES was probably the most commonly prescribed colloidal preparation in the world. Such prescription continued despite concerns that starch molecules might accumulate in vital organs and that starch preparations might decrease the coagulability of blood. These concerns have led to two pivotal multicenter double-blind controlled trials in critically ill patients, one conducted in Scandinavia in septic Intensive Care Unit (ICU) patients, and the other conducted in Australia and New Zealand in a heterogeneous group of ICU patients. Both studies found that the infusion of HES increased the risk of needing renal replacement therapy. In addition, the Scandinavian study found that HES increased mortality. Subsequent meta-analyses have confirmed these findings. In response to such strong evidence, over the last few weeks, the Food and Drug Administration has issued a major warning and, in Europe, the EMA suspended the marketing authorization for HES. At least in Europe, the clinical story of HES seems to have come to an end.
authors.affiliation: Australian and New Zealand Intensive care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia - rinaldo.bellomo@austin.org.au.
authors.forename: C
authors.initials: C
authors.lastname: Aubron
authors.forename: R
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D016638:Critical Illness; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D015337:Multicenter Studies as Topic; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D017582:Renal Replacement Therapy; D012306:Risk
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes