title: Estimation of cytogenetic risk among coke oven workers exposed to polycyclic aromatic hydrocarbons.
abstract: Polycyclic aromatic hydrocarbons (PAHs) result from the incomplete combustion of natural or synthetic organic materials. The working environment at a coke plant can negatively affect the employed workers who were exposed to coke oven emissions containing PAHs, which formed and released into the environment by the process of pyrolysis of coke. This study aims to analyze the relationship between the exposure of PAHs and the risk of genetic damages such as chromosomal alteration (CA), micronucleus (MN), and DNA damage (PCR-RFLP) in peripheral blood lymphocytes of 27 coke oven workers and equal number of control subjects. The exposed subjects and controls were divided into two groups based on their age (group I<35 years and group II ≥35 years). The exposed subjects were further classified into two groups based on the exposure period (<12 years and ≥12 years). The frequencies of CA and MN in exposed subjects are relatively high with respect to controls. The XRCC1 399 Arg/gln polymorphism showed a substantial smaller difference in allele frequencies between exposed and control subjects. Based on present data, it was concluded that coke oven workers under risk should be monitored for adverse effects of the any long-term exposure.
authors.affiliation: Human Molecular Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Sureshkumar
authors.forename: Vellingiri
authors.initials: V
authors.lastname: Balachandar
authors.forename: Subramaniam Mohana
authors.initials: SM
authors.lastname: Devi
authors.forename: Meyyazhagan
authors.initials: M
authors.lastname: Arun
authors.forename: Alagamuthu
authors.initials: A
authors.lastname: Karthickkumar
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Balamuralikrishnan
authors.forename: Kathannan
authors.initials: K
authors.lastname: Sankar
authors.forename: Shafi Ahammed Khan
authors.initials: SA
authors.lastname: Mustaqahamed
authors.forename: Shanwaz N
authors.initials: SN
authors.lastname: Dharwadkar
authors.forename: Keshavarao
authors.initials: K
authors.lastname: Sasikala
authors.forename: Ssang-Goo
authors.initials: SG
authors.lastname: Cho
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003077:Coke / Q000633:toxicity*; D020552:Comet Assay; D053938:DNA Fragmentation / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008669:Metallurgy; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity*; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D003077:Coke; D004268:DNA-Binding Proteins; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human