title: Potassium bromide-associated panniculitis.
abstract: Two cases of panniculitis associated with administration of potassium bromide in dogs are reported. Both dogs were treated with potassium bromide for idiopathic epilepsy for over 1 year. Dose increases in both cases were associated with panniculitis, characterised by painful subcutaneous nodules in a generalised distribution over the trunk. Nodule eruption waxed and waned in one dog and was persistent in the other. In both cases, panniculitis was accompanied by lethargy and pyrexia. Panniculitis, lethargy and pyrexia resolved and failed to recur after discontinuation of potassium bromide. No other cause of panniculitis could be determined for either dog. Panniculitis has been reported after administration of potassium bromide in humans and may be a form of drug-induced erythema nodosum. To the authors' knowledge, these are the first reports of potassium bromide-associated panniculitis in dogs.
authors.affiliation: Department of Dermatology, Veterinary Specialty Hospital, San Diego, CA, 92121, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Boynosky
authors.forename: L B
authors.initials: LB
authors.lastname: Stokking
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001965:Bromides / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy; D004285:Dogs; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000662:veterinary; D005260:Female; D015434:Panniculitis / Q000139:chemically induced / Q000662:veterinary*; D017680:Potassium Compounds / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; C039004:potassium bromide