title: Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter.
abstract: Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.
authors.affiliation: School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
authors.forename: Devis
authors.initials: D
authors.lastname: Sinani
authors.forename: Ethan
authors.initials: E
authors.lastname: Cordes
authors.forename: Aspen
authors.initials: A
authors.lastname: Workman
authors.forename: Prasanth
authors.initials: P
authors.lastname: Thunuguntia
authors.forename: Clinton
authors.initials: C
authors.lastname: Jones
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D015967:Gene Expression Regulation, Viral; D006561:Herpes Simplex / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics* / Q000378:metabolism; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics / Q000378:metabolism*; D000071250:Snail Family Transcription Factors; D013312:Stress, Physiological; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000187:drug effects / Q000378:metabolism* / Q000821:virology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D017874:Immediate-Early Proteins; C414172:KLF15 protein, human; D051741:Kruppel-Like Transcription Factors; D009687:Nuclear Proteins; D050783:Proto-Oncogene Proteins c-ets; C000604407:SNAI1 protein, human; C403974:SPDEF protein, human; C000604449:Snai2 protein, mouse; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors; D003907:Dexamethasone; D044767:Ubiquitin-Protein Ligases; C051804:Vmw110 protein, Human herpesvirus 1
references.citation: Physiol Rev. 2010 Oct;90(4):1337-81
references.pmid: 20959618
references.citation: J Virol. 1991 Jan;65(1):195-205
references.pmid: 1845884
references.citation: J Gen Virol. 1996 Aug;77 ( Pt 8):1853-63
references.pmid: 8760437
references.citation: J Virol. 2001 Apr;75(7):3240-9
references.pmid: 11238850
references.citation: J Virol. 2013 Jan;87(2):1183-92
references.pmid: 23152506
references.citation: J Cell Physiol. 2001 Aug;188(2):143-60
references.pmid: 11424081
references.citation: PLoS Pathog. 2009 Mar;5(3):e1000352
references.pmid: 19325890
references.citation: J Virol. 2002 Jul;76(13):6771-9
references.pmid: 12050390
references.citation: J Virol. 1989 Nov;63(11):4579-89
references.pmid: 2552142
references.citation: Vaccine. 2000 Jul 15;18(27):3185-95
references.pmid: 10856798
references.citation: J Virol. 1992 Apr;66(4):2484-90
references.pmid: 1312639
references.citation: J Virol. 2001 Nov;75(21):10401-8
references.pmid: 11581408
references.citation: Vet Microbiol. 2002 Apr 22;86(1-2):139-55
references.pmid: 11888697
references.citation: J Virol. 2002 Mar;76(5):2449-59
references.pmid: 11836423
references.citation: J Virol. 2013 Oct;87(20):11214-22
references.pmid: 23926348
references.citation: J Biol Chem. 2001 Sep 14;276(37):34355-8
references.pmid: 11443140
references.citation: J Biol Chem. 2004 Apr 23;279(17):16954-62
references.pmid: 14960588
references.citation: J Virol. 2006 Apr;80(7):3360-8
references.pmid: 16537603
references.citation: J Virol. 1990 Sep;64(9):4489-98
references.pmid: 2166826
references.citation: Genome Biol. 2003;4(2):206
references.pmid: 12620113
references.citation: Nature. 1985 Sep 12-18;317(6033):179-82
references.pmid: 2993923
references.citation: Clin Microbiol Rev. 2003 Jan;16(1):79-95
references.pmid: 12525426
references.citation: PLoS Pathog. 2012 Feb;8(2):e1002540
references.pmid: 22383875
references.citation: Adv Virus Res. 1998;51:81-133
references.pmid: 9891586
references.citation: J Virol. 2009 Sep;83(18):9591-5
references.pmid: 19570863
references.citation: Brain Res. 1994 Feb 14;636(2):338-42
references.pmid: 8012818
references.citation: J Virol. 2005 Dec;79(23):14516-25
references.pmid: 16282451
references.citation: J Virol. 2007 Nov;81(21):11781-9
references.pmid: 17715242
references.citation: J Virol. 1996 Aug;70(8):5476-86
references.pmid: 8764059
references.citation: J Virol. 1997 Jul;71(7):5268-76
references.pmid: 9188595
references.citation: BMC Mol Biol. 2005 Jun 17;6:15
references.pmid: 15963234
references.citation: J Virol. 2010 Jan;84(1):188-200
references.pmid: 19828605
references.citation: J Virol. 2001 Jul;75(13):6143-53
references.pmid: 11390616
references.citation: J Gen Virol. 2001 May;82(Pt 5):1117-1122
references.pmid: 11297686
references.citation: J Virol. 1993 Sep;67(9):5383-93
references.pmid: 8394454
references.citation: J Virol. 2011 Dec;85(23):12124-33
references.pmid: 21937659
references.citation: Am J Respir Cell Mol Biol. 2011 Sep;45(3):642-9
references.pmid: 21257922
references.citation: J Virol. 1992 May;66(5):2763-72
references.pmid: 1313901
references.citation: J Virol. 2000 Jun;74(11):5337-46
references.pmid: 10799611
references.citation: BMC Genet. 2010 Feb 08;11:12
references.pmid: 20141633
references.citation: J Virol. 1989 Nov;63(11):4882-9
references.pmid: 2552160
references.citation: J Virol. 2012 Mar;86(5):2459-73
references.pmid: 22190728
references.citation: Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18820-4
references.pmid: 22065742
references.citation: Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14616-21
references.pmid: 22908263
references.citation: J Immunol. 1996 Oct 15;157(8):3542-9
references.pmid: 8871654
references.citation: J Virol. 2006 Nov;80(22):10919-30
references.pmid: 16943285
references.citation: Vet Microbiol. 2006 Mar 31;113(3-4):199-210
references.pmid: 16352404
references.citation: Interdiscip Perspect Infect Dis. 2010;2010:262415
references.pmid: 20169002
references.citation: Annu Rev Med. 1997;48:231-40
references.pmid: 9046958
references.citation: Endocr Rev. 1997 Jun;18(3):306-60
references.pmid: 9183567
references.citation: J Virol. 1990 Jul;64(7):3471-85
references.pmid: 2161950