title: Altered resting-state network connectivity in congenital blind.
abstract: The brain of congenital blind (CB) has experienced a series of structural and functional alterations, either undesirable outcomes such as atrophy of the visual pathway due to sight loss from birth, or compensatory plasticity to interact efficiently with the environment. However, little is known, so far, about alterations in the functional architecture of resting-state networks (RSNs) in CB. This study aimed to investigate intra- and internetwork connectivity differences between CB and sighted controls (SC), using independent component analysis (ICA) on resting state functional MRI data. Compared with SC, CB showed significantly increased network connectivity within the salience network (SN) and the occipital cortex. Moreover, CB exhibited enhanced internetwork connectivity between the SN and the frontoparietal network (FPN) and between the FPN and the occipital cortex; however, they showed decreased internetwork connectivity between the occipital cortex and the sensorimotor network. These findings suggest that CB experience large scale reorganization at the level of the functional network. More importantly, the enhanced intra- and internetwork connectivity of the SN, FPN, and occipital cortex in CB may improve their abilities to identify salient stimuli, to initiate the executive function, and to top-down control of attention, which are critical for the CB to guide appropriate behavior and to better adaption to the environment.
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Qin
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yunting
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D001766:Blindness / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: MRI; congenital blind; independent component analysis; resting-state network
references.citation: Hum Brain Mapp. 2011 Dec;32(12):2075-95
references.pmid: 21162045
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12569-74
references.pmid: 18723676
references.citation: Neuroscience. 2006 Oct 27;142(3):843-58
references.pmid: 16934941
references.citation: Nat Rev Neurosci. 2009 Jan;10(1):59-70
references.pmid: 19096369
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Brain Res. 1990 Feb 26;510(1):115-21
references.pmid: 2322834
references.citation: Neuroimage. 2002 Aug;16(4):977-84
references.pmid: 12202085
references.citation: Cereb Cortex. 2006 Nov;16(11):1653-61
references.pmid: 16400157
references.citation: Neuroimage. 2009 Aug 1;47(1):98-106
references.pmid: 19361567
references.citation: Neuroimage. 2005 Jan 15;24(2):323-31
references.pmid: 15627575
references.citation: Neuroimage. 2001 Apr;13(4):577-88
references.pmid: 11305887
references.citation: Cereb Cortex. 2007 Dec;17(12):2933-9
references.pmid: 17372275
references.citation: Neuron. 2010 Oct 6;68(1):138-48
references.pmid: 20920797
references.citation: Brain. 2009 Dec;132(Pt 12):3467-80
references.pmid: 19892766
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 May 29;362(1481):761-72
references.pmid: 17400538
references.citation: Neuroimage. 2007 Aug 1;37(1):212-20
references.pmid: 17560797
references.citation: Proc Natl Acad Sci U S A. 1989 Jun;86(11):4297-301
references.pmid: 2726773
references.citation: Neurosci Lett. 2005 May 6;379(2):127-31
references.pmid: 15823429
references.citation: Neural Comput. 1995 Nov;7(6):1129-59
references.pmid: 7584893
references.citation: J Neurosci. 2007 Feb 28;27(9):2349-56
references.pmid: 17329432
references.citation: Brain Res. 1997 Mar 7;750(1-2):235-44
references.pmid: 9098549
references.citation: Neuroimage. 2006 Feb 15;29(4):1359-67
references.pmid: 16260155
references.citation: J Neurosci. 2007 Oct 3;27(40):10734-41
references.pmid: 17913907
references.citation: Neuroimage. 2004 Jan;21(1):340-51
references.pmid: 14741672
references.citation: Neuroimage. 2007 Oct 1;37(4):1091-6; discussion 1097-9
references.pmid: 17368915
references.citation: Curr Biol. 2005 Jul 12;15(13):R488-90
references.pmid: 16005276
references.citation: Trends Cogn Sci. 2007 Jun;11(6):229-35
references.pmid: 17475536
references.citation: Nat Rev Neurosci. 2001 Apr;2(4):251-62
references.pmid: 11283748
references.citation: Neuroimage. 2006 May 15;31(1):279-85
references.pmid: 16443376
references.citation: J Neurosci. 2009 Feb 18;29(7):2205-11
references.pmid: 19228973
references.citation: Annu Rev Neurosci. 2005;28:377-401
references.pmid: 16022601
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13256-60
references.pmid: 16916936
references.citation: Neural Comput. 1999 Nov 15;11(8):2061-80
references.pmid: 10578044
references.citation: Neuroimage. 2003 May;19(1):125-31
references.pmid: 12781732
references.citation: Neuroimage. 2000 Apr;11(4):326-33
references.pmid: 10725188
references.citation: Brain. 1998 Jul;121 ( Pt 7):1213-29
references.pmid: 9679774
references.citation: Exp Brain Res. 2008 May;187(1):41-9
references.pmid: 18224306
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
references.pmid: 11209064
references.citation: Nat Neurosci. 2011 May 29;14(7):830-2
references.pmid: 21623362
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
references.pmid: 15976020
references.citation: PLoS Biol. 2005 Feb;3(2):e27
references.pmid: 15678166
references.citation: Neuroimage. 2010 Jan 1;49(1):134-40
references.pmid: 19643183
references.citation: Neuroreport. 2011 Mar 9;22(4):190-4
references.pmid: 21304328
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
references.pmid: 16945915
references.citation: Magn Reson Med. 1995 Oct;34(4):537-41
references.pmid: 8524021
references.citation: Hum Brain Mapp. 2006 Apr;27(4):325-39
references.pmid: 16142777
references.citation: Neuroimage. 2013 Aug 1;76:439-41
references.pmid: 22440651
references.citation: Brain. 2001 Oct;124(Pt 10):2074-86
references.pmid: 11571223
references.citation: Neuroimage. 2007 Jun;36(2):411-7
references.pmid: 17442594
references.citation: Brain. 2007 Aug;130(Pt 8):2085-96
references.pmid: 17533167
references.citation: Neurosci Lett. 1993 Feb 19;150(2):162-4
references.pmid: 8469415
references.citation: Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):745-9
references.pmid: 1704130
references.citation: Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
references.pmid: 16087444
references.citation: Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):781-95
references.pmid: 15937012
references.citation: Neuroscience. 2006 Apr 28;139(1):51-8
references.pmid: 16352402
references.citation: J Magn Reson Imaging. 2004 Mar;19(3):365-8
references.pmid: 14994306
references.citation: Cereb Cortex. 2007 Sep;17 Suppl 1:i125-35
references.pmid: 17725995
references.citation: Magn Reson Imaging. 2002 May;20(4):305-17
references.pmid: 12165349
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51
references.pmid: 16788060
references.citation: Nat Neurosci. 2003 Jul;6(7):758-66
references.pmid: 12808458
references.citation: Neuroimage. 2005 Mar;25(1):294-311
references.pmid: 15734364
references.citation: Nature. 1996 Apr 11;380(6574):526-8
references.pmid: 8606771
references.citation: Brain Struct Funct. 2010 Jun;214(5-6):655-67
references.pmid: 20512370
references.citation: J Comp Neurol. 1994 Sep 22;347(4):570-84
references.pmid: 7529266
references.citation: Neuroimage. 2012 Mar;60(1):623-32
references.pmid: 22233733
references.citation: Curr Biol. 2011 Mar 8;21(5):363-8
references.pmid: 21333539
references.citation: Neuroimage. 2012 Jan 2;59(1):431-8
references.pmid: 21810475
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references.pmid: 17704812
references.citation: Hum Brain Mapp. 2001 Nov;14(3):140-51
references.pmid: 11559959
references.citation: Hum Brain Mapp. 2008 May;29(5):533-43
references.pmid: 17525980
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references.pmid: 18400922
references.citation: Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13170-5
references.pmid: 17670949
references.citation: Trends Neurosci. 1995 Jan;18(1):36-43
references.pmid: 7535489
references.citation: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
references.pmid: 12506194
references.citation: Neuroimage. 2012 Feb 1;59(3):2142-54
references.pmid: 22019881
references.citation: Neurosci Lett. 2006 Jan 9;392(1-2):38-42
references.pmid: 16198053
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references.pmid: 15070770
references.citation: Nat Rev Neurosci. 2002 Aug;3(8):655-66
references.pmid: 12154366
references.citation: NMR Biomed. 1997 Jun-Aug;10(4-5):165-70
references.pmid: 9430343