title: Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury.
abstract: Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metabolites and significant reductions in the levels of 29 others, including several metabolites produced by amino acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed.
authors.affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University.
authors.forename: Gi-Wook
authors.initials: GW
authors.lastname: Hwang
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Lee
authors.forename: Min-Seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sato
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism*; D002952:Citric Acid Cycle; D005978:Glutathione / Q000378:metabolism; D008297:Male; D055432:Metabolomics / Q000379:methods; D008767:Methylmercury Compounds / Q000378:metabolism* / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D011687:Purines / Q000378:metabolism
chemical_list: D000596:Amino Acids; D008767:Methylmercury Compounds; D011687:Purines; D005978:Glutathione; C030985:purine