title: [Correlation between cognitive impairment and plasma levels of clusterin/ApoJ in Parkinson disease patients not affected by dementia].
abstract: Cognitive impairment is frequent in patients with Parkinson's disease (PD), and can range from mild deterioration to dementia. Recently a contribution of Alzheimer's disease for the cognitive dysfunction in PD has been proposed, whereas the presence of tau protein and amyloid was recognized. Clusterin/ApoJ is a protein involved in the deposition of beta-amyloid and in its neurotoxicity. In this study we aimed to investigate the clusterin/ApoJ's plasma levels in patients with PD to assess its potential role in fisiopathogenetic cognitive impairment.
authors.forename: Artor
authors.initials: A
authors.lastname: Niccoli Asabella
authors.forename: Marilena
authors.initials: M
authors.lastname: Ruggeri
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Polimeno
authors.forename: Cristina
authors.initials: C
authors.lastname: Spinelli
authors.forename: Marella
authors.initials: M
authors.lastname: Polito
authors.forename: Michele
authors.initials: M
authors.lastname: Pennelli
authors.forename: Corinna
authors.initials: C
authors.lastname: Altini
authors.forename: Maria Sara
authors.initials: MS
authors.lastname: De Caro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Defazio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rubini
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D015415:Biomarkers; D051152:Clusterin / Q000097:blood*; D060825:Cognitive Dysfunction / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D018592:Cross-Over Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C495242:CLU protein, human; D051152:Clusterin