title: SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.
authors.affiliation: Department of Cellular and Molecular Physiology; Pennsylvania State University; College of Medicine; Hershey, PA USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Nie
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Shi
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D048429:Cell Size; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D005786:Gene Expression Regulation; D052216:Glucagon-Like Peptide 1 / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000473:pathology; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D018345:Mice, Knockout; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D007328:Insulin; D046912:Multiprotein Complexes; D052216:Glucagon-Like Peptide 1; C546843:mTOR protein, mouse; C496825:Brsk2 protein, mouse; D000076222:Mechanistic Target of Rapamycin Complex 1; D017346:Protein Serine-Threonine Kinases; C491654:Stk11 protein, mouse; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose
keywords: AMPK-related kinase; GLP‑1; LKB1; incretin; insulin secretion; type 2 diabetes
references.citation: J Clin Invest. 2011 Jun;121(6):2118-25
references.pmid: 21633180
references.citation: Mol Cell Biol. 2008 May;28(9):2971-9
references.pmid: 18316403
references.citation: Endocrinology. 2009 Jun;150(6):2518-25
references.pmid: 19372197
references.citation: J Clin Invest. 2006 Jul;116(7):1776-83
references.pmid: 16823475
references.citation: Annu Rev Pharmacol Toxicol. 2012;52:381-400
references.pmid: 22017684
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9250-5
references.pmid: 18587048
references.citation: Nature. 2000 Dec 21-28;408(6815):994-7
references.pmid: 11140689
references.citation: Biochem J. 2010 Jul 15;429(2):323-33
references.pmid: 20465544
references.citation: Gastroenterology. 2007 May;132(6):2131-57
references.pmid: 17498508
references.citation: Cell. 2007 May 4;129(3):549-63
references.pmid: 17482548
references.citation: PLoS One. 2012;7(12):e51870
references.pmid: 23284795
references.citation: J Biol Chem. 2007 Apr 6;282(14):10341-51
references.pmid: 17287212
references.citation: Biochemistry. 2008 Apr 1;47(13):4151-9
references.pmid: 18324781
references.citation: Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62
references.pmid: 23922392
references.citation: Science. 2005 Feb 11;307(5711):929-32
references.pmid: 15705853
references.citation: Biochem J. 2003 May 1;371(Pt 3):761-74
references.pmid: 12589707
references.citation: Trends Endocrinol Metab. 2011 Mar;22(3):94-102
references.pmid: 21269838
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5680-5
references.pmid: 17372192
references.citation: Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1013-22
references.pmid: 19690069
references.citation: Cell Cycle. 2007 Aug 15;6(16):1966-9
references.pmid: 17721078
references.citation: EMBO J. 2004 Feb 25;23(4):833-43
references.pmid: 14976552
references.citation: Int J Obes (Lond). 2011 Sep;35 Suppl 3:S22-5
references.pmid: 21912382
references.citation: Cell Metab. 2009 Oct;10(4):285-95
references.pmid: 19808021
references.citation: Biochem Biophys Res Commun. 2006 Sep 8;347(4):867-71
references.pmid: 16870137
references.citation: J Endocrinol. 2005 Nov;187(2):225-35
references.pmid: 16293770
references.citation: Cell Metab. 2006 Mar;3(3):153-65
references.pmid: 16517403
references.citation: EMBO J. 2005 May 18;24(10):1810-20
references.pmid: 15889149
references.citation: Nat Cell Biol. 2009 Sep;11(9):1081-92
references.pmid: 19648910
references.citation: Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E677-85
references.pmid: 23341495
references.citation: Nat Cell Biol. 2000 Nov;2(11):805-11
references.pmid: 11056535
references.citation: Cell Metab. 2009 Oct;10(4):296-308
references.pmid: 19808022
references.citation: Diabetes. 2002 Dec;51 Suppl 3:S434-42
references.pmid: 12475787
references.citation: J Mol Med (Berl). 2012 May;90(5):575-85
references.pmid: 22105852
references.citation: J Clin Invest. 2010 Dec;120(12):4316-31
references.pmid: 21084751
references.citation: J Biol Chem. 2012 Jul 27;287(31):26435-44
references.pmid: 22669945
references.citation: Genes Dev. 2005 Sep 15;19(18):2199-211
references.pmid: 16166381
references.citation: Cell Metab. 2013 Jun 4;17(6):819-837
references.pmid: 23684623
references.citation: Mol Cell Biol. 2013 Jul;33(13):2527-34
references.pmid: 23629625
references.citation: Mol Cell Biol. 2010 Nov;30(21):5043-56
references.pmid: 20733003
references.citation: Diabetes. 2008 Apr;57(4):945-57
references.pmid: 18174523
references.citation: J Biol Chem. 2012 Nov 2;287(45):38305-15
references.pmid: 22992738
references.citation: Mol Cell Endocrinol. 2009 Jan 15;297(1-2):41-9
references.pmid: 18611432
references.citation: Neuron. 2013 Jul 10;79(1):39-53
references.pmid: 23790753
references.citation: Cell Metab. 2005 Jan;1(1):15-25
references.pmid: 16054041
references.citation: Obes Rev. 2011 Aug;12(8):593-601
references.pmid: 21401851
references.citation: Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1261-73
references.pmid: 20354156
references.citation: Diabetologia. 2010 May;53(5):924-36
references.pmid: 20221584
references.citation: Nat Rev Mol Cell Biol. 2009 May;10(5):307-18
references.pmid: 19339977