title: Association between vitamin D receptor poly(A) polymorphism and breast cancer risk: a meta-analysis.
abstract: Vitamin D receptor (VDR) poly(A) is a common genetic polymorphism in the VDR gene, and it has been implicated to be associated with breast cancer risk. However, previous studies on the association reported inconclusive results. We performed this meta-analysis to comprehensively assess the association. Eligible studies were searched in PubMed and EMBASE databases. Odds ratio (OR) and its 95% confidence interval (95% CI) were used for statistical analysis. A total 6,631 cases and 6,718 controls from 11 case-control studies were finally included into the meta-analysis. Meta-analysis of total eligible studies showed that VDR poly(A) polymorphism was not associated with the risk of breast cancer (S versus L: OR = 0.99, 95% CI of 0.90-1.09, P = 0.84; SS versus LL: OR = 0.96, 95% CI of 0.79-1.18, P = 0.70; SS/LS versus LL: OR = 0.96, 95% CI of 0.83-1.12, P = 0.63; SS versus LL/LS: OR = 1.00, 95% CI of 0.91-1.10, P = 0.98). Meta-analysis of studies with high quality also showed that there was no association between VDR poly(A) polymorphism and breast cancer risk. In addition, in the subgroup analysis by ethnicity, no significant association was found among Caucasians. Therefore, the meta-analysis suggests that VDR poly(A) polymorphism is not associated with the risk of breast cancer. Large well-designed studies are necessary to clarify the possible association in Asians.
authors.affiliation: First Affiliated Hospital of Liaoning Medical College, Jinzhou, 121001, China.
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Xu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
authors.forename: Lixue
authors.initials: L
authors.lastname: Gu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhou
mesh_terms: D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011061:Poly A; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D011061:Poly A
references.citation: Nat Rev Clin Oncol. 2011 Feb;8(2):65-6
references.pmid: 21278769
references.citation: Cancer Causes Control. 2000 Jan;11(1):25-30
references.pmid: 10680726
references.citation: Int J Cancer. 2012 Jan 15;130(2):405-18
references.pmid: 21365644
references.citation: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
references.pmid: 21296855
references.citation: Lancet. 2011 Oct 22;378(9801):1461-84
references.pmid: 21924486
references.citation: Tumour Biol. 2013 Apr;34(2):1255-62
references.pmid: 23381647
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Breast Cancer Res. 2007;9(1):R9
references.pmid: 17244366
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120
references.citation: Cell Oncol (Dordr). 2011 Apr;34(2):71-88
references.pmid: 21336636
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: Carcinogenesis. 1999 Nov;20(11):2131-5
references.pmid: 10545416
references.citation: Breast Cancer Res Treat. 2012 Apr;132(2):683-91
references.pmid: 22130867
references.citation: JAMA. 2012 Nov 14;308(18):1898-905
references.pmid: 23150009
references.citation: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references.pmid: 22237781
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5472-81
references.pmid: 15328186
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1775-83
references.pmid: 17855696
references.citation: Br J Cancer. 2001 Jul 20;85(2):171-5
references.pmid: 11461072
references.citation: Ann Epidemiol. 2009 Jul;19(7):462-7
references.pmid: 19230714
references.citation: Breast Cancer Res Treat. 2009 Sep;117(2):391-9
references.pmid: 19145484
references.citation: CMAJ. 2011 Dec 13;183(18):2109-16
references.pmid: 22065359
references.citation: J Clin Invest. 2011 Oct;121(10):3789-96
references.pmid: 21965335
references.citation: Anticancer Res. 2009 Sep;29(9):3511-36
references.pmid: 19667145
references.citation: Breast Cancer Res. 2007;9(6):R84
references.pmid: 18067661
references.citation: Cancer Detect Prev. 2009;32(5-6):386-94
references.pmid: 19588543