title: Stress granules and cell signaling: more than just a passing phase?
abstract: Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors, and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As signaling centers, SG formation communicates a 'state of emergency', and their transient existence alters multiple signaling pathways by intercepting and sequestering signaling components. SG assembly and downstream signaling functions may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Kedersha
authors.forename: Pavel
authors.initials: P
authors.lastname: Ivanov
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins
keywords: cell signaling; intrinsically disordered; protein aggregation; stress granules; translation
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