title: CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.
abstract: The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.
authors.affiliation: Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA. jmorrow@buffalo.edu.
authors.forename: Sarina J
authors.initials: SJ
authors.lastname: Dorazio
authors.forename: Abiola O
authors.initials: AO
authors.lastname: Olatunde
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Spernyak
authors.forename: Janet R
authors.initials: JR
authors.lastname: Morrow
mesh_terms: D000577:Amides / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure
chemical_list: D000577:Amides; D003287:Contrast Media; D056831:Coordination Complexes; D008024:Ligands; D003035:Cobalt
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