title: Structures and anti-cancer properties of two binuclear copper complexes.
abstract: The crystals of two binuclear copper-based complexes were obtained. One complex can remarkably induce apoptosis and inhibit angiogenesis to mediate tumour growth at a greater extent. Furthermore, this complex showed a strong energy-dependent and non-endocytotic uptake and exhibited multiple anti-cancer functions by inhibiting the expressions of p-Akt and p-Erk1/2 proteins and by decreasing the levels of reactive oxygen species.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, China. tliuliu@jnu.edu.cn.
authors.forename: Xiu Ying
authors.initials: XY
authors.lastname: Qin
authors.forename: Li Cong
authors.initials: LC
authors.lastname: Yang
authors.forename: Fang Ling
authors.initials: FL
authors.lastname: Le
authors.forename: Qian Qian
authors.initials: QQ
authors.lastname: Yu
authors.forename: Dong Dong
authors.initials: DD
authors.lastname: Sun
authors.forename: Ya Nan
authors.initials: YN
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D003300:Copper