title: Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation.
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Grövdal
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Karimi
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Tobiasson
authors.affiliation: Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Reinius
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Jansson
authors.affiliation: Center for Bioscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Ekwall
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ungerstedt
authors.affiliation: 1] Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden [2] Center for Bioscience, Karolinska Institutet, Stockholm, Sweden [3] Molecular Medicine Research Program, Biomedicum, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kere
authors.affiliation: 1] Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden [2] Molecular Medicine Research Program, Biomedicum, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland.
authors.forename: D
authors.initials: D
authors.lastname: Greco
authors.affiliation: Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Hellström-Lindberg
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D001374:Azacitidine / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D019175:DNA Methylation / Q000187:drug effects*; D044127:Epigenesis, Genetic / Q000187:drug effects; D057890:Epigenomics; D006657:Histones / Q000378:metabolism*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000964:Antimetabolites, Antineoplastic; D006657:Histones; D001374:Azacitidine
references.citation: Leukemia. 2009 Jun;23(6):1019-28
references.pmid: 19194470
references.citation: Cancer Res. 2006 May 15;66(10):5495-503
references.pmid: 16707479
references.citation: Epigenetics. 2010 Apr;5(3):229-40
references.pmid: 20305384
references.citation: Cancer Res. 2009 Oct 15;69(20):8127-32
references.pmid: 19808971
references.citation: Epigenetics. 2009 Apr 1;4(3):176-84
references.pmid: 19421002
references.citation: Leukemia. 2012 Aug;26(8):1804-11
references.pmid: 22343522
references.citation: Blood. 2010 Jan 7;115(1):107-21
references.pmid: 19887673
references.citation: Genome Res. 2012 Feb;22(2):246-58
references.pmid: 22156296
references.citation: Lancet Oncol. 2009 Mar;10(3):223-32
references.pmid: 19230772
references.citation: Br J Haematol. 2010 Aug;150(3):293-302
references.pmid: 20497178
references.citation: Exp Hematol. 2008 Feb;36(2):149-57
references.pmid: 18206726
references.citation: Leukemia. 2005 Jan;19(1):103-11
references.pmid: 15510208
references.citation: Br J Haematol. 2010 Apr;149(2):244-9
references.pmid: 20136825
references.citation: Blood. 2009 Oct 15;114(16):3448-58
references.pmid: 19652201