title: The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma.
abstract: OBJECTIVE
  The onset of chronic subdural hematoma may be associated with direct or indirect minor injuries to the head or a poorly repaired vascular injury. Endothelial progenitor cells happen to be one of the key factors involved in hemostasis and vascular repair. This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma.
  
  
  METHODS
  We enrolled 30 patients with diagnosed chronic subdural hematoma by computer tomography scanning and operating procedure at Tianjin Medical University General Hospital from July 2009 to July 2011. Meanwhile, we collected 30 cases of peripheral blood samples from healthy volunteers over the age of 50. Approximately 2 ml of blood was taken from veins of the elbow to test the peripheral blood routine and coagulation function. The content of endothelial progenitor cells in peripheral blood mononuclear cells was determined by flow cytometry.
  
  
  RESULTS
  The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls. There were no significant differences between the two groups regarding the blood routine and coagulation function. However, the levels of circulating endothelial progenitor cells were significantly different between the recurrent group and the non-recurrent group.
  
  
  CONCLUSIONS
  The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls. Meanwhile, the level of endothelial progenitor cells in recurrent patients was significantly lower than the level in patients without recurrence. Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma.
authors.affiliation: Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Department of Health Care Medicine, Tianjin,, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Jianning
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001777:Blood Coagulation; D016022:Case-Control Studies; D002452:Cell Count; D016009:Chi-Square Distribution; D042783:Endothelial Cells / Q000166:cytology*; D005260:Female; D005434:Flow Cytometry; D020200:Hematoma, Subdural, Chronic / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012016:Reference Values; D012737:Sex Factors; D013234:Stem Cells / Q000166:cytology*
chemical_list: D015415:Biomarkers
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