title: Association of polymorphisms in interleukin-18 and interleukin-28B genes with outcomes of hepatitis B virus infections: a meta-analysis.
abstract: Several polymorphisms in the interleukin-18 (IL-18) and nterleukin-28B (IL-28B) genes have been reported to influence hepatitis B virus (HBV) infection. However, the published findings have been conflicting. We conducted meta-analyses of randomized, controlled trials to address the association of IL-18 or IL-28B polymorphisms and the outcomes of HBV infection. Weipu, Wanfang, CNKI, MEDLINE, PubMed, EMBASE, and Cochrane Library databases were employed to search for citations using the MeSH terms as "interleukin-18"/"interleukin-28B" AND "HBV" AND "gene" AND "polymorphism" without any restriction in language and publication year. Meta-analysis was conducted by RevMan 5.0 software. The results showed that the IL28B rs8099917 AA genotype (AA vs AC + CC: odds ratio (OR) = 0.63, 95 % confidence interval (CI) = 0.46-0.87) was associated with a decreased risk of hepatocellular carcinoma (HCC). Carriage of IL28B rs12979860 CC genotype was associated with an increased risk for developing liver cirrhosis among patients with HBV infection (CC vs CT + TT: OR = 1.39, 95 % CI = 1.04-1.85). Further well-designed large studies are warranted to confirm the mechanisms by which these are involved in these outcomes of HBV infection.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, China Medical University, Shenyang, 110001, Liaoning, People's Republic of China, nn001007@163.com.
authors.forename: Pu
authors.initials: P
authors.lastname: Xia
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Dao Song
authors.initials: DS
authors.lastname: Dong
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Xing
authors.forename: Yang
authors.initials: Y
authors.lastname: Bai
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000821:virology; D056726:Genetic Association Studies; D006509:Hepatitis B / Q000150:complications / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D007372:Interferons; D020382:Interleukin-18 / Q000235:genetics*; D007378:Interleukins / Q000235:genetics*; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology / Q000821:virology; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000821:virology; D020641:Polymorphism, Single Nucleotide; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D020382:Interleukin-18; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
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