title: Late adolescent expression of GluN2B transmission in the prefrontal cortex is input-specific and requires postsynaptic protein kinase A and D1 dopamine receptor signaling.
abstract: BACKGROUND
  Refinement of mature cognitive functions, such as working memory and decision making, typically takes place during adolescence. The acquisition of these functions is linked to the protracted development of the prefrontal cortex (PFC) and dopamine facilitation of glutamatergic transmission. However, the mechanisms that support these changes during adolescence remain elusive.
  
  
  METHODS
  Electrophysiological recordings (in vitro and in vivo) combined with pharmacologic manipulations were employed to determine how N-methyl-D-aspartate transmission in the medial PFC changes during the adolescent transition to adulthood. The relative contribution of GluN2B transmission and its modulation by postsynaptic protein kinase A and D1 receptor signaling were determined in two distinct age groups of rats: postnatal day (P)25 to P40 and P50 to P80.
  
  
  RESULTS
  We found that only N-methyl-D-aspartate receptor transmission onto the apical dendrite of layer V pyramidal neurons undergoes late adolescent remodeling due to a functional emergence of GluN2B function after P40. Both protein kinase A and dopamine D1 receptor signaling are required for the functional expression of GluN2B transmission and to sustain PFC plasticity in response to ventral hippocampal, but not basolateral amygdala, inputs.
  
  
  CONCLUSIONS
  Thus, the late adolescent acquisition of GluN2B function provides a mechanism for dopamine D1-mediated regulation of PFC responses in an input-specific manner.
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
authors.forename: Eden
authors.initials: E
authors.lastname: Flores-Barrera
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Thomases
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Heng
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
authors.forename: Daryn K
authors.initials: DK
authors.lastname: Cass
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois.
authors.forename: Adriana
authors.initials: A
authors.lastname: Caballero
authors.affiliation: Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois. Electronic address: kuei-yuan.tseng@rosalindfranklin.edu.
authors.forename: Kuei Y
authors.initials: KY
authors.lastname: Tseng
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology*; D046690:Deep Brain Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D008297:Male; D017397:Prefrontal Cortex / Q000254:growth & development* / Q000502:physiology*; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: C121001:NR2B NMDA receptor; D017447:Receptors, Dopamine D1; D016194:Receptors, N-Methyl-D-Aspartate; D017868:Cyclic AMP-Dependent Protein Kinases
keywords: Adolescence; NMDA; amygdala; dopamine; hippocampus; signaling
references.citation: Psychopharmacology (Berl). 2014 Apr;231(8):1789-96
references.pmid: 23907651
references.citation: J Comp Neurol. 2002 Nov 11;453(2):116-30
references.pmid: 12373778
references.citation: J Comp Neurol. 1996 May 20;369(1):1-15
references.pmid: 8723699
references.citation: J Neurosci. 2013 Jan 2;33(1):26-34
references.pmid: 23283319
references.citation: Pharmacol Biochem Behav. 2009 Sep;93(3):212-21
references.pmid: 19593842
references.citation: Biol Psychiatry. 2013 Oct 1;74(7):490-501
references.pmid: 23558299
references.citation: Behav Neurosci. 2003 Aug;117(4):728-37
references.pmid: 12931958
references.citation: Alcohol Clin Exp Res. 2003 Nov;27(11):1736-42
references.pmid: 14634488
references.citation: J Neurosci. 2002 Feb 1;22(3):1063-71
references.pmid: 11826135
references.citation: J Neurosci. 2012 Nov 14;32(46):16223-32
references.pmid: 23152606
references.citation: Child Dev. 2010 Nov-Dec;81(6):1641-60
references.pmid: 21077853
references.citation: Child Dev. 2004 Sep-Oct;75(5):1357-72
references.pmid: 15369519
references.citation: J Physiol. 2000 Aug 1;526 Pt 3:571-87
references.pmid: 10922009
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16791-6
references.pmid: 18922773
references.citation: J Neurosci. 2012 Aug 8;32(32):10915-24
references.pmid: 22875926
references.citation: Psychopharmacology (Berl). 2005 Apr;179(1):99-107
references.pmid: 15678364
references.citation: Neurobiol Aging. 2011 Apr;32(4):698-706
references.pmid: 19446371
references.citation: J Neurophysiol. 1998 Feb;79(2):555-66
references.pmid: 9463421
references.citation: Neuropsychologia. 1990;28(6):517-27
references.pmid: 2203993
references.citation: Brain Res. 1996 May 13;720(1-2):211-9
references.pmid: 8782914
references.citation: Behav Neurosci. 2001 Aug;115(4):934-9
references.pmid: 11508732
references.citation: Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12876-80
references.pmid: 10536016
references.citation: J Neurosci. 1999 Nov 1;19(21):9587-603
references.pmid: 10531461
references.citation: Learn Mem. 2010 May 26;17(6):289-96
references.pmid: 20504949
references.citation: Nature. 1994 Mar 10;368(6467):144-7
references.pmid: 8139656
references.citation: Synapse. 2011 Apr;65(4):278-86
references.pmid: 20687106
references.citation: Cereb Cortex. 2013 Jun;23(6):1396-409
references.pmid: 22615141
references.citation: Neuropsychopharmacology. 2013 Apr;38(5):729-42
references.pmid: 23303054
references.citation: Neuron. 1994 Mar;12(3):529-40
references.pmid: 7512349
references.citation: Prog Neurobiol. 2005 Jun;76(3):189-211
references.pmid: 16181726
references.citation: Neuropharmacology. 2008 Dec;55(7):1081-94
references.pmid: 18755202
references.citation: J Neurosci. 2003 Nov 5;23(31):9987-95
references.pmid: 14602812
references.citation: Biol Psychiatry. 2003 Sep 1;54(5):504-14
references.pmid: 12946879
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:111-26
references.pmid: 18400927
references.citation: Neurotox Res. 2010 Nov;18(3-4):306-12
references.pmid: 20151241
references.citation: Neuron. 1993 Feb;10(2):267-78
references.pmid: 8439412
references.citation: Brain Res. 2002 Aug 16;946(2):314-22
references.pmid: 12137936
references.citation: Neuropharmacology. 2011 May;60(6):953-62
references.pmid: 21288471
references.citation: J Neurosci. 2000 Nov 15;20(22):RC106
references.pmid: 11069975
references.citation: Cereb Cortex. 2005 Jan;15(1):49-57
references.pmid: 15217899
references.citation: Psychopharmacology (Berl). 2011 Aug;216(4):525-35
references.pmid: 21384103
references.citation: Neuron. 2013 Feb 20;77(4):736-49
references.pmid: 23439125
references.citation: Learn Mem. 2013 May 15;20(6):290-4
references.pmid: 23676200
references.citation: J Neurosci. 2006 Apr 26;26(17):4690-700
references.pmid: 16641250
references.citation: J Neurosci. 1998 Feb 15;18(4):1613-21
references.pmid: 9454866
references.citation: J Neurosci. 2006 Aug 16;26(33):8549-58
references.pmid: 16914681
references.citation: Biol Psychiatry. 2007 Oct 1;62(7):730-8
references.pmid: 17207473
references.citation: Neuron. 2005 Sep 15;47(6):859-72
references.pmid: 16157280
references.citation: Neuroscience. 2011 Sep 29;192:515-23
references.pmid: 21645591