title: Mechanism research on combination of decoction for reinforcing lung qi and argon helium lancet in treatment of non-small cell lung cancer.
abstract: OBJECTIVE
  To observe the effect of decoction for reinforcing lung Qi on T-lymphocytic function, interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in peripheral blood of patients with non-small cell lung cancer after operation with argon helium lancet in order to explore its mechanism.
  
  
  METHODS
  A total of 76 patients suffering from non-small cell lung cancer without surgical indication were randomly divided into a treatment group treated with decoction for reinforcing lung Qi and argon helium lancet and a control group treated with argon helium lancet only to observe lymphocytic proliferation, detect the percentage of positive cells in the T-lymphocyte CD28 with flow cytometry and detect the expression of IL-2 and TNF-alpha in peripheral blood with enzyme linked immunosorbent assay.
  
  
  RESULTS
  Proliferation of T-lymphocytes and expression of CD28, IL-2 and TNF-alpha in peripheral blood after treatment in the treatment group were more obviously strengthened than those before treatment and those in the control group (all P < 0.05).
  
  
  CONCLUSIONS
  The mechanism of using decoction for reinforcing lung Qi and argon helium lancet to treat lung cancer may be realized through promoting T-lymphocytic proliferation, up-regulating expression of CD28, IL-2 and TNF-alpha, and activating T-cells.
authors.affiliation: Department of Traditional Chinese Medicine, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shaodan
authors.initials: S
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Cao
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Yueyong
authors.initials: Y
authors.lastname: Xiao
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics / Q000378:metabolism; D054020:Lasers, Gas; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019413:Qi; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha