title: Human papillomavirus infection in women in four regions of Senegal.
abstract: Cervical cancer is the most frequent cancer among women in Senegal. However, there are few data concerning the human papillomavirus (HPV) types inducing neoplasia and cervical cancers and their prevalence in the general population of Senegal. The aim of this study is to determine the prevalence of HPV infection in Senegalese women aged 18 years and older in Dakar Region and three other regions. Cervical samples were collected from 498 women aged 18-80 years (mean, 42.1 years) in Dakar Region. Also, 438 samples were collected from three other regions: Thiès, Saint-Louis, and Louga. The samples were screened for 21 HPV genotypes using an HPV type-specific E7 PCR bead-based multiplex genotyping assay (TS-MPG). The prevalence of high risk (HR)-HPV in Dakar Region was 17.4%. HPV 52 (3.2%) was the most prevalent HPV type, followed by HPV 31 (3.0%) and HPV 16, 45, and 53 (all 2.8%). In the Thiès, Saint-Louis, and Louga Regions, the prevalence of HR-HPV was 23.2%, 13.1%, and 19.4%, respectively. The study revealed the specificity of HPV prevalence in Dakar Region and other regions of Senegal. The observed patterns show some differences compared with other regions of the world. These findings raise the possibility that, in addition to HPV 16 and HPV 18, other HPV types should be considered for a vaccination program in Senegal. However, additional studies to determine the HPV type distribution in cervical cancer specimens in Senegal are required to further corroborate this hypothesis.
authors.affiliation: International Agency for Research on Cancer (IARC/WHO), Lyon, France; Laboratory of Bacteriology and Virology, Aristide Le Dantec Hospital, Dakar, Senegal; Cancer Institute, Aristide Le Dantec Hospital, Dakar, Senegal.
authors.forename: El Hadji Seydou
authors.initials: el HS
authors.lastname: Mbaye
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.forename: Ahmadou
authors.initials: A
authors.lastname: Dem
authors.forename: Sandrine
authors.initials: S
authors.lastname: McKay-Chopin
authors.forename: Ndeye Coumba
authors.initials: NC
authors.lastname: Toure-Kane
authors.forename: Souleymane
authors.initials: S
authors.lastname: Mboup
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.forename: Bakary S
authors.initials: BS
authors.lastname: Sylla
authors.forename: Cheikh Saad Bouh
authors.initials: CS
authors.lastname: Boye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D050725:Papillomavirus E7 Proteins / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D012675:Senegal / Q000453:epidemiology; D055815:Young Adult
chemical_list: D050725:Papillomavirus E7 Proteins
keywords: Senegal; cervical cancer; papillomavirus