title: Aspirin discontinuation syndromes: clinical implications of basic research studies.
abstract: Abrupt discontinuation of many drugs used in medicine causes withdrawal syndromes, some of which can be fatal. Discontinuation of a number of cardiovascular drugs can increase the risk of cardiovascular events. Whereas aspirin administration is known to decrease the risk of vascular ischemic problems, aspirin withdrawal may temporarily increase the risk of thrombotic events. Indeed, aspirin withdrawal has been associated with an increased risk of thrombosis both in clinical and fundamental research studies. Such complications occur within the first month after interrupting aspirin therapy and their mechanism remains unexplained. We have previously demonstrated that aspirin, when injected as a single high dose (100 mg/kg), induces a prothrombotic state in the rat, similar to that described above, 8 and 10 days after administration. This effect in the rat may be reproduced 1 hour after a single injection of ultra-low-dose aspirin. Caution is therefore required regarding the possibility of drug discontinuation effects within the framework of drug safety evaluation.
authors.affiliation: Laboratoire d'Hématologie, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France, christian.doutremepuich@heph.u-bordeaux2.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Doutremepuich
authors.forename: Omar
authors.initials: O
authors.lastname: Aguejouf
authors.forename: Vanessa
authors.initials: V
authors.lastname: Desplat
authors.forename: Francisco X
authors.initials: FX
authors.lastname: Eizayaga
mesh_terms: D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D035843:Biomedical Research / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000473:pathology*; D013927:Thrombosis / Q000378:metabolism / Q000473:pathology*
chemical_list: D001241:Aspirin