title: Placental growth hormone (PGH), pituitary growth hormone (GH1), insulin-like growth factor (IGF-I) and ghrelin in pregnant women's blood serum.
abstract: OBJECTIVE
  The aim of this work is to evaluate levels of placental growth hormone (PGH), pituitary growth hormone (GH1), insulin-like growth factor (IGF-I) and ghrelin in pregnant women's blood serum before, during and after delivery. Furthermore, the aim is to search for links and interdependence of GH1, PGH and IGF-I concentrations.
  
  
  METHODS
  Seventy nine blood samples were taken one to two hours before, during and half an hour after expulsion of placenta. All proteins studied were determined by ELISA method, using ELISA Kit.
  
  
  RESULTS
  The highest PGH concentration and IGF-I concentration in pregnant women's blood serum was observed before delivery while GH1 concentration was lowest. During and after delivery PGH and IGF-I concentration decreased proportionately and pituitary growth hormone concentration increased accordingly. About half an hour after delivery of the placenta, GH1 concentration was highest.
  
  
  CONCLUSIONS
  In pregnant women's blood there is a metabolic interdependence between PGH and IGF-I. Their concentration increases proportionately during pregnancy and decreases after delivery. It appears that labor and delivery releases GH1 blockade, which level rises three-fold during delivery. After parturition its role and concentration returns to levels before pregnancy.
authors.affiliation: Department of Clinical Auxology and Pediatrics Nursing, Division of Diabetology and Obesity of the Developmental Age, Poznan University of Medical Sciences, Poland. akedzia@ump.edu.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kedzia
authors.forename: Agata
authors.initials: A
authors.lastname: Tarka
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Petriczko
authors.forename: Dominik
authors.initials: D
authors.lastname: Pruski
authors.forename: Kinga
authors.initials: K
authors.lastname: Iwaniec
mesh_terms: D015415:Biomarkers / Q000097:blood; D036861:Delivery, Obstetric; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054439:Ghrelin / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D010926:Placental Hormones / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
chemical_list: D015415:Biomarkers; D054439:Ghrelin; D010926:Placental Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone