title: The use of stem cells for the treatment of spinal surgical conditions.
abstract: Spinal pathologies are a major burden on society and individuals. Recent years have seen a large number of studies dedicated to the use of stem cells in spinal surgery. This review focuses on recent advances and controversies regarding the applications of stem cells in spinal fusion surgery, spinal cord injury and intervertebral disc degeneration. There are significant concerns regarding the ethics and risks of stem cell use. Animal models do not always accurately depict the human condition. While a great deal has been achieved, successful translation into clinical practice is needed. However there is no doubt that stem cells have a major role to play in the future management of spinal conditions.
authors.affiliation: University College London, Institute of Orthopaedic and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, United Kingdom. mukai.cg@mac.com.
authors.forename: Syed
authors.initials: S
authors.lastname: Aftab
authors.forename: Mukai
authors.initials: M
authors.lastname: Chimutengwende-Gordon
authors.forename: Atif
authors.initials: A
authors.lastname: Malik
authors.forename: Robert
authors.initials: R
authors.lastname: Lee
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000628:therapy*; D010012:Osteogenesis; D019651:Plastic Surgery Procedures; D018570:Risk Assessment; D013119:Spinal Cord Injuries / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*