title: Antifungal activity of Cymbopogon winterianus jowitt ex bor against Candida albicans.
abstract: Candida albicans is an opportunistic yeast and a member of the normal human flora that commonly causes infections in patients with any type of deficiency of the immune system. The essential oils have been tested for antimycotic activity and pose much potential as antifungal agents. This work investigated the activity of the essential oil of Cymbopogon winterianus against C. albicans by MIC, MFC and time-kill methods. The essential oil (EO) was obtained by hydrodistillation using a Clevenger-type apparatus. It was tested fifteen strains of C. albicans. The MIC was determined by the microdilution method and the MFC was determined when an aliquot of the broth microdilution was cultivated in SDA medium. The phytochemical analysis of EO showed presence of citronellal (23,59%), geraniol (18,81%) and citronellol (11,74%). The EO showed antifungal activity, and the concentrations 625 µg/mL and 1250 µg/mL inhibited the growth of all strains tested and it was fungicidal, respectively. The antimicrobial activity of various concentrations of EO was analyzed over time, it was found concentration-dependent antifungal activity, whose behavior was similar to amphotericin B and nystatin.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Centro de Ciências da Saúde, Universidade Federal da Paraíba , João Pessoa. PB , Brasil ; Centro de Educação e Saúde, Universidade Federal de Campina Grande , Cuité, PB , Brasil.
authors.forename: Wylly Araújo
authors.initials: WA
authors.lastname: de Oliveira
authors.forename: Fillipe
authors.initials: F
authors.lastname: de Oliveira Pereira
authors.forename: Giliara Carol Diniz Gomes
authors.initials: GC
authors.lastname: de Luna
authors.forename: Igara Oliveira
authors.initials: IO
authors.lastname: Lima
authors.forename: Paulo Alves
authors.initials: PA
authors.lastname: Wanderley
authors.forename: Rita Baltazar
authors.initials: RB
authors.lastname: de Lima
authors.forename: Edeltrudes
authors.initials: E
authors.lastname: de Oliveira Lima
keywords: Candida albicans; Cymbopogon winterianus; antifungal
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