title: miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma.
abstract: Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.
authors.affiliation: Department of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado;
authors.forename: Paige E
authors.initials: PE
authors.lastname: Bennett
authors.forename: Lynne
authors.initials: L
authors.lastname: Bemis
authors.forename: David A
authors.initials: DA
authors.lastname: Norris
authors.forename: Yiqun G
authors.initials: YG
authors.lastname: Shellman
mesh_terms: D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000097:blood; D049109:Cell Proliferation; D016922:Cellular Senescence; D016147:Genes, Tumor Suppressor; D042822:Genomic Instability; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: BRAF; MITF; miR-137; miR-18b; miR-214
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