title: Emergency presentation of cancer and short-term mortality.
abstract: BACKGROUND
  The short-term survival following a cancer diagnosis in England is lower than that in comparable countries, with the difference in excess mortality primarily occurring in the months immediately after diagnosis. We assess the impact of emergency presentation (EP) on the excess mortality in England over the course of the year following diagnosis.
  
  
  METHODS
  All colorectal and cervical cancers presenting in England and all breast, lung, and prostate cancers in the East of England in 2006-2008 are included. The variation in the likelihood of EP with age, stage, sex, co-morbidity, and income deprivation is modelled. The excess mortality over 0-1, 1-3, 3-6, and 6-12 months after diagnosis and its dependence on these case-mix factors and presentation route is then examined.
  
  
  RESULTS
  More advanced stage and older age are predictive of EP, as to a lesser extent are co-morbidity, higher income deprivation, and female sex. In the first month after diagnosis, we observe case-mix-adjusted excess mortality rate ratios of 7.5 (cervical), 5.9 (colorectal), 11.7 (breast ), 4.0 (lung), and 20.8 (prostate) for EP compared with non-EP.
  
  
  CONCLUSIONS
  Individuals who present as an emergency experience high short-term mortality in all cancer types examined compared with non-EPs. This is partly a case-mix effect but EP remains predictive of short-term mortality even when age, stage, and co-morbidity are accounted for.
authors.affiliation: National Cancer Intelligence Network, 133-155 Wellington House, Waterloo Road, London SE1 8UG, UK.
authors.forename: S
authors.initials: S
authors.lastname: McPhail
authors.forename: L
authors.initials: L
authors.lastname: Elliss-Brookes
authors.forename: J
authors.initials: J
authors.lastname: Shelton
authors.forename: A
authors.initials: A
authors.lastname: Ives
authors.forename: M
authors.initials: M
authors.lastname: Greenslade
authors.forename: S
authors.initials: S
authors.lastname: Vernon
authors.forename: E J A
authors.initials: EJ
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Richards
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D004630:Emergencies / Q000453:epidemiology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D055815:Young Adult
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