title: The effect of testosterone levels on mood in men: a review.
abstract: BACKGROUND
  The effects of both high and low levels of testosterone are wide ranging and can include changes in mood, often overlapping with symptoms of mood disorders.
  
  
  OBJECTIVE
  We sought to review the literature on the correlation of high and low levels of testosterone on mood disorders in men.
  
  
  RESULTS
  Based on limited studies, high levels of testosterone are related to increased rates of depression as well as hypomania, whereas low levels of testosterone are related to depressive disorders in certain subpopulations of patients. There is insufficient evidence to conclude that low testosterone level routinely leads to major depressive disorder in men.
  
  
  CONCLUSIONS
  Physicians should consider screening for low testosterone levels in certain subgroups of depressed men.
authors.affiliation: Massachusetts General Hospital, Harvard Medical School.
authors.forename: Justin M
authors.initials: JM
authors.lastname: Johnson
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Nachtigall
authors.forename: Theodore A
authors.initials: TA
authors.lastname: Stern
mesh_terms: D000339:Affect; D001714:Bipolar Disorder / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism*; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone