title: The bidirectional relationship between body mass index and treatment outcome in adolescents with treatment-resistant depression.
abstract: OBJECTIVE
  Depression and obesity are associated, but the impact of obesity on depression treatment outcome, or, conversely, the impact of treatment on body mass index (BMI) in depressed adolescents has not been reported. In this article, we examine the bidirectional relationships between BMI and treatment response in adolescents with treatment-resistant depression.
  
  
  METHODS
  Participants in the Treatment of Selective Serotonin Reuptake Inhibitor (SSRI) Resistant Depression in Adolescents (TORDIA) study had height and weight assessed at baseline, weekly for the first 6 weeks, biweekly for the next 6 weeks, and monthly from weeks 12 through 24. The impact of baseline BMI as a predictor and moderator of treatment response was assessed. In addition, participants' changes in BMI were assessed as a function of specific treatment assignment and treatment response.
  
  
  RESULTS
  Participants assigned to SSRIs had a greater increase in BMI-for-age-sex z-score and weight than did those assigned to venlafaxine. Post-hoc, those treated with paroxetine or citalopram had the biggest increases in BMI, relative to fluoxetine or venlafaxine. Overweight or obesity was neither a predictor nor a moderator of treatment outcome, nor of subsequent BMI change.
  
  
  CONCLUSIONS
  Overweight status does not appear to affect treatment response in adolescents with resistant depression. The successful treatment of depression does not appear to favorably affect weight or BMI. Fluoxetine and venlafaxine are less likely to cause an increase in BMI than paroxetine or citalopram.
authors.affiliation: 1 Wayne State University School of Medicine , Detroit, Michigan.
authors.forename: Brandon
authors.initials: B
authors.lastname: Mansoor
authors.forename: Manivel
authors.initials: M
authors.lastname: Rengasamy
authors.forename: Robert
authors.initials: R
authors.lastname: Hilton
authors.forename: Giovanna
authors.initials: G
authors.lastname: Porta
authors.forename: Jiayan
authors.initials: J
authors.lastname: He
authors.forename: Anthony
authors.initials: A
authors.lastname: Spirito
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Emslie
authors.forename: Taryn L
authors.initials: TL
authors.lastname: Mayes
authors.forename: Gregory
authors.initials: G
authors.lastname: Clarke
authors.forename: Karen Dineen
authors.initials: KD
authors.lastname: Wagner
authors.forename: Wael
authors.initials: W
authors.lastname: Shamseddeen
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: Neal
authors.initials: N
authors.lastname: Ryan
authors.forename: David
authors.initials: D
authors.lastname: Brent
mesh_terms: D000293:Adolescent; D018687:Antidepressive Agents, Second-Generation / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015992:Body Mass Index; D002648:Child; D015283:Citalopram / Q000493:pharmacokinetics / Q000627:therapeutic use; D003511:Cyclohexanols / Q000493:pharmacokinetics / Q000627:therapeutic use; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005473:Fluoxetine / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000493:pharmacokinetics / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D003511:Cyclohexanols; D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride
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