title: Hypoxic pulmonary vasoconstriction in humans.
abstract: Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although considerable progress has been made to describe the phenomenon at the macroscopic level and explain it at the microscopic level, we are far from a universal agreement about the process in humans. This review attempts to highlight some of the important evidence bases of hypoxic pulmonary vasoconstriction in humans and the significant gaps in our knowledge that would need bridging.
authors.affiliation: Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham HU16 5JQ, UK.
authors.forename: Priyadharshanan
authors.initials: P
authors.lastname: Ariyaratnam
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Loubani
authors.forename: Alyn H
authors.initials: AH
authors.lastname: Morice
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000502:physiology*; D010477:Perfusion; D014661:Vasoconstriction / Q000502:physiology*
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