title: Zinc ion implantation-deposition modification of titanium for enhanced adhesion of focal plaques of osteoblast-like cells.
abstract: BACKGROUND
  Surface modification by ion implantation-deposition is well established in materials science and can be an effective way to improve biocompatibility. The aim of this study is to evaluate the chemical composition of a modified titanium (Ti) surface after zinc (Zn) ion implantation and deposition and examine the effect of the modification on the formation of cellular focal adhesion plaques in vitro.
  
  
  METHODS
  cp-Ti discs were modified with Zn ion implantation and deposition via PIIID. The chemical composition of the surface modification was characterized by X-ray photoelectron spectroscopy (XPS). The formation of focal adhesion plaques on the modified Ti was investigated with human osteoblast-like MG-63 cells that were seeded onto the Ti surfaces and quantified by morphometric analysis under a confocal microscope.
  
  
  RESULTS
  XPS data revealed that the modified Zn-Ti surface consisted of Ti, oxygen, Zn, and carbon. In addition, Gaussian fitting of the spectra indicated that the modified surface contained titanium dioxide and zinc oxide. After 6 hours of MG-63 cell culture, there were significantly more focal adhesion plaques on the modified surfaces than observed on the nonmodified Ti (P < 0.05).
  
  
  CONCLUSIONS
  Zn ion implantation and deposition greatly improved the biocompatibility of Ti for the growth of MG-63 cells.
authors.affiliation: Institute of Stomatology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China; Urumqi Stomatological Hospital, Urumqi, Xinjiang 830002, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Xin-Ying
authors.initials: XY
authors.lastname: Tan
authors.forename: Chang-Kui
authors.initials: CK
authors.lastname: Liu
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D056951:Photoelectron Spectroscopy; D014025:Titanium / Q000494:pharmacology; D015034:Zinc Oxide / Q000494:pharmacology
chemical_list: C009495:titanium dioxide; D014025:Titanium; D015034:Zinc Oxide