title: Pharmacokinetic profile of spectinomycin in rats.
abstract: Following intravenous (IV) administration, the pharmacokinetics of spectinomycin in rats was found to be on par with its profile in other mammalian species including humans with respect to its overall excretion and half-life at effective concentrations. This study, however, indicates that a small fraction of the spectinomycin dose is retained in peripheral tissues for a prolonged period of time at low concentrations.
authors.affiliation: Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, 881 Madison Ave, Suite 444, Memphis, TN 38163, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Madhura
authors.forename: R
authors.initials: R
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Meibohm
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D000198:Spectinomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D000198:Spectinomycin
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