title: Preliminary evaluation of antimicrobial activity of cream formulated with essential oil of Trachyuspermum ammi.
abstract: In our present research we studied physiochemical properties and antimicrobial activity of T. ammi (Trachyuspermum ammi) seeds. The seeds yielded 2.86% essential oil. Refractive index, specific gravity, acid value, and easter values were 1.496, 0.9212, 1.12 and 2.80 respectively. GLC was used to determine the composition of oil. The major component of oil was Thymol (55.308%). Antimicrobial activity of the oil was carried out against four species of bacteria and fungs. The oil was used to formulate a cream and the pH, physiochemical stability, phase separation and dermal irritation of cream were investigated. The cream was examined for healing wound in rabbits in comparison with Iodine tincture.
authors.affiliation: Department of Chemistry, University of Engineering & Technology, Lahore, Pakistan.
authors.forename: Gilani Rubina
authors.initials: GR
authors.lastname: Gilani
authors.forename: Zaid
authors.initials: Z
authors.lastname: Mahmood
authors.forename: Mushraf
authors.initials: M
authors.lastname: Hussain
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D029974:Carum / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D023421:Models, Animal; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D011817:Rabbits; D012639:Seeds; D063465:Skin Cream; D013943:Thymol / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile; D010938:Plant Oils; D013943:Thymol