title: Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro.
abstract: Brucellosis is an endemic zoonosis in Syria, affecting large numbers of animals and there are an increasing number of cases in humans. The aim of this study is to investigate the in vitro efficacy of various traditional and new antibiotics against 89 Brucella isolates (isolated from domestic animals) collected from different Syrian regions. Minimum inhibitory concentrations (MICs) of seventeen antibiotics were determined. Ciprofloxacin and ofloxacin were the most effective antibiotics, whereas sparfloxacin, levofloxacin, doxycycline and tetracycline had a moderate activity. In contrast, moxifloxacin and rifampicin had a low activity, while streptomycin, spiramycin and cephalosporines were ineffective. As a result, we come to the conclusion that a combination between one effective quinolone and doxycycline has a good efficacy against Brucella. Further in vivo studies are necessary to support this suggestion.
authors.affiliation: Department of Molecular Biology and Biotechnology, Atomic Energy Commission , P.O. Box 6091, Damascus , Syria.
authors.forename: Mazen
authors.initials: M
authors.lastname: Safi
authors.forename: Ayman
authors.initials: A
authors.lastname: Al-Mariri
keywords: Antibiotics; Brucella; quinolones
references.citation: J Chemother. 1994 Apr;6(2):102-6
references.pmid: 8077983
references.citation: Antimicrob Agents Chemother. 1989 Aug;33(8):1409-10
references.pmid: 2802568
references.citation: Pediatr Infect Dis J. 1990 Feb;9(2):74-9
references.pmid: 2314956
references.citation: Antimicrob Agents Chemother. 1986 Jan;29(1):182-3
references.pmid: 3729331
references.citation: World Health Organ Tech Rep Ser. 1986;740:1-132
references.pmid: 3097967
references.citation: Clin Infect Dis. 2006 Apr 15;42(8):1075-80
references.pmid: 16575723
references.citation: Emerg Infect Dis. 1997 Apr-Jun;3(2):213-21
references.pmid: 9204307
references.citation: Pediatr Infect Dis J. 1993 May;12(5):377-81
references.pmid: 8327297
references.citation: Int J Antimicrob Agents. 2004 Apr;23(4):405-7
references.pmid: 15081093
references.citation: Ann Clin Microbiol Antimicrob. 2006 Oct 02;5:24
references.pmid: 17014707
references.citation: J Infect. 1998 May;36(3):297-301
references.pmid: 9661940
references.citation: Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):443-8
references.pmid: 11756688
references.citation: J Antimicrob Chemother. 1992 Apr;29(4):357-60
references.pmid: 1607324
references.citation: Scand J Infect Dis. 2004;36(9):636-8
references.pmid: 15370648
references.citation: J Clin Microbiol. 2004 Dec;42(12):5439-43
references.pmid: 15583262
references.citation: Chemotherapy. 1995 Jul-Aug;41(4):253-6
references.pmid: 7555205
references.citation: Med Princ Pract. 2004 Jul-Aug;13(4):215-9
references.pmid: 15181327
references.citation: N Engl J Med. 2005 Jun 2;352(22):2325-36
references.pmid: 15930423
references.citation: J Clin Rheumatol. 2004 Dec;10(6):300-7
references.pmid: 17043537
references.citation: Antimicrob Agents Chemother. 1999 Jan;43(1):194-5
references.pmid: 9869594
references.citation: Braz J Microbiol. 2008 Apr;39(2):233-7
references.pmid: 24031207
references.citation: New Microbiol. 2008 Jan;31(1):47-55
references.pmid: 18437841
references.citation: Ann Saudi Med. 1993 Jan;13(1):37-40
references.pmid: 17587989
references.citation: Scand J Infect Dis. 2003;35(5):337-8
references.pmid: 12875523
references.citation: Ann Thorac Cardiovasc Surg. 2002 Dec;8(6):381-5
references.pmid: 12517300
references.citation: BMC Infect Dis. 2004 Jun 23;4:18
references.pmid: 15214959
references.citation: Med Princ Pract. 2005 Nov-Dec;14(6):413-6
references.pmid: 16220015
references.citation: Antimicrob Agents Chemother. 1991 Apr;35(4):756-9
references.pmid: 2069383
references.citation: Clin Microbiol Infect. 2002 Apr;8(4):240-2
references.pmid: 12047416