title: Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response.
abstract: Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI. Thus, we assessed the anti-GPI Ab response in asymptomatic individuals living in an area of the Brazilian Amazon that has a high level of malaria transmission. For comparative purposes, we also investigated the Ab response to a crude extract prepared from Plasmodium falciparum, the merozoite surface protein (MSP)3 antigen of P. falciparum and the MSP 1 antigen of Plasmodium vivax (PvMSP1-19) in these individuals and in Angolan patients with acute malaria. Our data suggest that the Ab response against P. falciparum GPI is not associated with P. falciparum asymptomatic infection in individuals who have been chronically exposed to malaria in the Brazilian Amazon. However, this Ab response could be related to ongoing parasitaemia (as was previously shown) in the Angolan patients. In addition, our data show that PvMSP1-19may be a good marker antigen to reflect previous exposure to Plasmodium in areas that have a high transmission rate of P. vivax.
authors.affiliation: Instituto Oswaldo Cruz, Laboratório de Pesquisa em Malária.
authors.forename: Larissa Rodrigues
authors.initials: LR
authors.lastname: Gomes
authors.forename: Paulo Renato Rivas
authors.initials: PR
authors.lastname: Totino
authors.forename: Maria Carmen Arroyo
authors.initials: MC
authors.lastname: Sanchez
authors.forename: Elsa Paula da Silva Kaingona
authors.initials: EP
authors.lastname: Daniel
authors.forename: Cristiana Santos de
authors.initials: CS
authors.lastname: Macedo
authors.forename: Filomeno
authors.initials: F
authors.lastname: Fortes
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Coura
authors.forename: Silvia Maria Di
authors.initials: SM
authors.lastname: Santi
authors.forename: Guilherme Loureiro
authors.initials: GL
authors.lastname: Werneck
authors.forename: Martha Cecilia
authors.initials: MC
authors.lastname: Suárez-Mutis
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Ferreira-da-Cruz
authors.forename: Cláudio Tadeu
authors.initials: CT
authors.lastname: Daniel-Ribeiro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000810:Angola; D000917:Antibody Formation; D000953:Antigens, Protozoan / Q000276:immunology*; D058345:Asymptomatic Infections; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D017261:Glycosylphosphatidylinositols / Q000276:immunology*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000276:immunology*; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000737:chemistry / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D055815:Young Adult
chemical_list: D000953:Antigens, Protozoan; D017261:Glycosylphosphatidylinositols; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C089133:merozoite surface protein 3, Plasmodium
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