title: Seroprevalence of Sindbis virus and associated risk factors in northern Sweden.
abstract: Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4-13·0, P = 0·011).
authors.affiliation: Department of Clinical Microbiology, Infectious Diseases,Umeå University,Umeå,Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Ahlm
authors.affiliation: Department of Public Health and Clinical Medicine, Sunderby Research Unit,Umeå University,Umeå,Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Eliasson
authors.affiliation: Department of Virology, Haartman Institute and Department of Veterinary Biosciences,University of Helsinki,Finland.
authors.forename: O
authors.initials: O
authors.lastname: Vapalahti
authors.affiliation: Department of Clinical Microbiology, Virology,Umeå University,Umeå,Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Evander
mesh_terms: D000328:Adult; D000368:Aged; D018354:Alphavirus Infections / Q000097:blood / Q000453:epidemiology* / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012845:Sindbis Virus / Q000276:immunology / Q000302:isolation & purification*; D013548:Sweden / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
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