title: Brief Report: Antibodies Reacting to Brain Tissue in Basque Spanish Children with Autism Spectrum Disorder and Their Mothers.
abstract: Previous investigations found that a subset of children with autism spectrum disorder (ASD) in California possessed plasma autoantibodies that reacted intensely with brain interneurons or other neural profiles. Moreover, for several cohorts of American women, maternal autoantibody reactivity to specific fetal brain proteins was highly specific to mothers of children with ASD. We sought to determine whether children and their mothers from a regionally specific cohort from the Basque Country of Spain demonstrated similar reactivity. Some children's plasma reacted to interneurons, beaded axons or other neural profiles with no difference in the occurrence of these antibodies in children with or without ASD. Findings on the maternal antibodies confirmed previous research; plasma reactivity to fetal brain a combination of proteins at 37 and 73 kDa or 39 and 73 kDa was found exclusively in mothers of children with ASD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA, USA.
authors.forename: Christy C
authors.initials: CC
authors.lastname: Rossi
authors.forename: Joaquin
authors.initials: J
authors.lastname: Fuentes
authors.forename: Judy
authors.initials: J
authors.lastname: Van de Water
authors.forename: David G
authors.initials: DG
authors.lastname: Amaral
references.citation: Brain Behav Immun. 2007 Mar;21(3):351-7
references.pmid: 17029701
references.citation: J Neuroimmunol. 2009 Feb 15;207(1-2):111-6
references.pmid: 19157572
references.citation: Eur Child Adolesc Psychiatry. 2012 Mar;21(3):141-7
references.pmid: 22323074
references.citation: MMWR Surveill Summ. 2012 Mar 30;61(3):1-19
references.pmid: 22456193
references.citation: J Autism Dev Disord. 1999 Aug;29(4):327-31
references.pmid: 10478732
references.citation: J Neurovirol. 1999 Dec;5(6):570-8
references.pmid: 10602398
references.citation: Ann Neurol. 2005 Jan;57(1):67-81
references.pmid: 15546155
references.citation: J Pediatr. 1999 May;134(5):607-13
references.pmid: 10228297
references.citation: Immunity. 2004 Aug;21(2):179-88
references.pmid: 15308099
references.citation: Neurotoxicology. 2008 Mar;29(2):226-31
references.pmid: 18078998
references.citation: J Neuroimmunol. 2006 Sep;178(1-2):149-55
references.pmid: 16842863
references.citation: Ann N Y Acad Sci. 2007 Jun;1107:92-103
references.pmid: 17804536
references.citation: Ann N Y Acad Sci. 2009 Sep;1173:130-6
references.pmid: 19758141
references.citation: J Autism Dev Disord. 2012 Jul;42(7):1435-45
references.pmid: 22012245
references.citation: Mol Autism. 2011 Apr 26;2:5
references.pmid: 21521495
references.citation: J Autism Dev Disord. 2006 Apr;36(3):429-35
references.pmid: 16568356
references.citation: Glia. 2001 Nov;36(2):118-24
references.pmid: 11596120
references.citation: J Neuroimmunol. 2008 Feb;194(1-2):165-72
references.pmid: 18093664
references.citation: Br J Psychiatry. 2009 Jun;194(6):500-9
references.pmid: 19478287
references.citation: Ann Neurol. 2003 Apr;53(4):533-7
references.pmid: 12666123
references.citation: Brain Behav Immun. 2011 Aug;25(6):1123-35
references.pmid: 21420487
references.citation: Brain Behav Immun. 2011 Mar;25(3):514-23
references.pmid: 21134442
references.citation: Brain Behav Immun. 2009 Jan;23(1):64-74
references.pmid: 18706993
references.citation: Biol Psychiatry. 2008 Oct 1;64(7):583-8
references.pmid: 18571628
references.citation: Biol Psychiatry. 2010 Aug 15;68(4):368-76
references.pmid: 20674603
references.citation: Front Neurosci. 2008 Jul 07;2(1):35-46
references.pmid: 18982105
references.citation: Curr Opin Neurobiol. 2007 Feb;17(1):103-11
references.pmid: 17275283
references.citation: Pediatr Neurol. 1997 Jul;17(1):88-90
references.pmid: 9308986