title: No increase of local recurrence rate in breast cancer patients treated with skin-sparing mastectomy followed by immediate breast reconstruction.
abstract: BACKGROUND
  The aim of this study was to evaluate the incidence of local recurrence after SSM with IBR and to determine whether complications lead to postponement of adjuvant therapy.
  
  
  METHODS
  Patients that underwent IBR after SSM between 2004 and 2011 were included.
  
  
  RESULTS
  A total of 157 reconstruction procedures were performed in 147 patients for invasive breast cancer (n = 117) and ductal carcinoma in situ (n = 40). The median follow-up was 39 months [range 6-97]. Estimated 5-year local recurrence rate was 2.9% (95% CI 0.1-5.7). The median time to start adjuvant therapy was 27.5 days [range 19-92] in 18 patients with complications, and 23.5 days [range 8-54] in 46 patients without complications (p = 0.025).
  
  
  CONCLUSIONS
  In our single-institution cohort, IBR after SSM carried an acceptable local recurrence rate. Complications caused a delay of adjuvant treatment but this was within guidelines and therefore not clinically relevant.
authors.affiliation: Maastricht University Medical Center+ (Maastricht UMC+), Department of Surgery, Maastricht, The Netherlands.
authors.forename: D R J
authors.initials: DR
authors.lastname: van Mierlo
authors.forename: T R
authors.initials: TR
authors.lastname: Lopez Penha
authors.forename: R J
authors.initials: RJ
authors.lastname: Schipper
authors.forename: M H
authors.initials: MH
authors.lastname: Martens
authors.forename: J
authors.initials: J
authors.lastname: Serroyen
authors.forename: M B I
authors.initials: MB
authors.lastname: Lobbes
authors.forename: E M
authors.initials: EM
authors.lastname: Heuts
authors.forename: S
authors.initials: S
authors.lastname: Tuinder
authors.forename: M L
authors.initials: ML
authors.lastname: Smidt
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000556:secondary / Q000628:therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects*; D015413:Mastectomy, Simple / Q000009:adverse effects*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D013997:Time Factors
keywords: Breast cancer; Local neoplasm recurrence; Post-operative complications; Reconstructive surgical procedure