title: Management of vaginal agenesis.
abstract: OBJECTIVE
  Mayer-Rokitansky-Küster-Hauser syndrome is undergoing new research outcomes involving genetics and management.
  
  
  RESULTS
  Recent literature supports a polygenic multifactorial genetic basis for the syndrome. Management is now predominantly by vaginal dilators and nonsurgical, but holistic. The future of uterine transplantation is discussed.
  
  
  CONCLUSIONS
  New developments open new possibilities for understanding the genetic basis of the disease, and research in this area will continue. Management in terms of fertility may have an added dimension if uterine transplantation and successful pregnancy outcome can be proven.
authors.affiliation: Queen Charlotte's and Chelsea Hospital, London, UK.
authors.forename: D Keith
authors.initials: DK
authors.lastname: Edmonds
mesh_terms: D058489:46, XX Disorders of Sex Development / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D004106:Dilatation; D005260:Female; D005298:Fertility / Q000235:genetics; D005820:Genetic Testing; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000601:surgery*; D009095:Mullerian Ducts / Q000002:abnormalities* / Q000601:surgery*; D011247:Pregnancy; D012725:Sexual Behavior; D000074122:Short Stature Homeobox Protein; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014599:Uterus / Q000002:abnormalities / Q000637:transplantation*; D014621:Vagina / Q000002:abnormalities* / Q000601:surgery*
chemical_list: D018398:Homeodomain Proteins; C106071:SHOX protein, human; D000074122:Short Stature Homeobox Protein