title: Sustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model.
abstract: BACKGROUND
  New methods for perfluorocarbon (PFC) application have been proposed which include aerosolization and vaporization. However, the experimental documentation of efficacy of vaporization of PFC in the treatment of acute respiratory distress syndrome (ARDS) is still lacking.
  
  
  OBJECTIVE
  This study aims to examine the effects of vaporized PFC on gas exchange and lung mechanics in a piglet model with ARDS.
  
  
  METHODS
  Lung injury was induced in 16 piglets by infusing detergent through tracheal intubation. Eight piglets were treated with vaporized PFC for 2 h followed by 6 h of volume-controlled ventilation. Another eight piglets receiving 8 h volume-controlled ventilation were used as controls. Blood gases, lung mechanical and hemodynamic parameters were measured.
  
  
  RESULTS
  Vaporized PFC treatment significantly increased oxygenation index (P/F ratio) and static lung compliance (Cst) 2 h after therapy compared with the control group (P<0.05). The P/F ratio reached a peak 5.5 h after the therapy and remained at an increased level for at least 6 h compared with the control group (P<0.001). Additionally, 6 h post treatment, peak inspiratory pressure was significantly reduced in PFC group when compared with the control group (P<0.05), and Cst was significantly higher in the PFC group than in the control group (P=0.001).
  
  
  CONCLUSIONS
  Inhalation of vaporized PFC results in sustained improvement of pulmonary gas exchange and lung mechanics in a detergent-induced animal model of lung injury. Therefore, the non-invasive vaporization application technique would be a reasonable alternative to administer perfluorocarbons in severe lung injury.
authors.affiliation: Department of Pulmonary Medicine, Chinese People's Liberation Army 313 Hospital, Huludao, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Wang
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Li
authors.forename: Youning
authors.initials: Y
authors.lastname: Liu
authors.forename: Haibo
authors.initials: H
authors.lastname: Yang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhao
authors.forename: Lixin
authors.initials: L
authors.lastname: Xie
authors.forename: Lihua
authors.initials: L
authors.lastname: Yin
mesh_terms: D055371:Acute Lung Injury / Q000378:metabolism / Q000503:physiopathology*; D000280:Administration, Inhalation; D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005466:Fluorocarbons / Q000008:administration & dosage*; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D009330:Nebulizers and Vaporizers; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D013552:Swine
chemical_list: D005466:Fluorocarbons
keywords: acute respiratory distress syndrome; fluorochemicals; inhalation; vaporization