title: Orthopedic surgery in rheumatoid arthritis in the era of biologic therapy.
abstract: OBJECTIVE
  To analyze sociodemographic and clinic-related factors associated with the use of orthopedic surgical procedures in rheumatoid arthritis (RA), focusing on the potential role of new biologic therapies.
  
  
  METHODS
  A retrospective medical record review was performed in a probability sample of 1272 patients with RA from 47 units distributed in 19 Spanish regions. Sociodemographic and clinical features, use of drugs, and arthritis-related joint surgeries were recorded following a standardized protocol.
  
  
  RESULTS
  A total of 94 patients (7.4%) underwent any orthopedic surgery during their disease course, with a total of 114 surgeries; 47 (41.2%) of these surgeries were total joint replacement (TJR). The median time to first orthopedic procedure was 7.9 years from the onset of RA symptoms, and the rate of orthopedic surgery (excluding TJR) was 4.5 procedures per 100 person-years from the beginning of RA, while the rate of TJR was 2.25 interventions per 100 person-years. A higher risk of undergoing an orthopedic surgical procedure was associated with taking nonsteroidal antiinflammatory drugs (NSAID) in the previous 2 years, female sex, longterm disease, and the presence of extraarticular complications. The risk factors for undergoing a TJR were being old, having a longterm disease, and taking biologic therapies.
  
  
  CONCLUSIONS
  In the era of biologics, our national audit found a low percentage of patients who underwent orthopedic surgery, probably reflecting a thorough management of the RA. Sociodemographic factors, longterm RA, extraarticular complications, and NSAID were associated with orthopedic surgery.
authors.affiliation: From the Rheumatology Unit, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos; Universidad Camilo Jose Cela; Agencia Española de Medicamentos y Productos Sanitarios; Rheumatology Unit, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Leon
authors.forename: Lydia
authors.initials: L
authors.lastname: Abasolo
authors.forename: Loreto
authors.initials: L
authors.lastname: Carmona
authors.forename: Luis
authors.initials: L
authors.lastname: Rodriguez-Rodriguez
authors.forename: Jose Ramon
authors.initials: JR
authors.lastname: Lamas
authors.forename: Cesar
authors.initials: C
authors.lastname: Hernandez-Garcia
authors.forename: Juan Angel
authors.initials: JA
authors.lastname: Jover
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D001688:Biological Products / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods / Q000706:statistics & numerical data*; D012737:Sex Factors
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products
keywords: BIOLOGIC THERAPY; ORTHOPEDICS; RHEUMATOID ARTHRITIS