title: Study of ehrlichiosis in kennel dogs under treatment and prevention during seven months in Dakar (Senegal).
abstract: In Dakar kennels where morbidity and mortality attributed to diseases transmitted by ticks were high, we conducted a field study to assess the prevalence of Ehrlichia canis, Anaplasma platys and Babesia spp. infections in two kennels (n = 34 dogs) and to study the impact of tick protection. The first day of the study, the E. canis PCR were positive in 18 dogs (53%). A. platys was found in one dog and all dogs were negative for Babesia spp. After one month of doxycycline treatment, the number of PCR positive dogs decreased significantly to 2 (5.9%). During seven months, all dogs were treated monthly topically with a novel combination (Certifect(®), Merial) delivering at least 6.7 mg fipronil/kg body weight, 8.0mg amitraz/kg and 6 mg (S)-methoprene/kg. The number of PCR positive dogs remained stable all over the seven months, with 4 dogs being positive at Day 90 and 2 at Day 210. The combination of treatment and monthly prevention had a significant effect in the two kennels. All dogs remained healthy, which was not the case in previous years.
authors.affiliation: Research Unit of Emerging Infectious and Tropical Diseases (URMITE) UMR-CNRS 7278-IRD 198, Marseille, France. Electronic address: bernard.davoust@gmail.com.
authors.forename: Bernard
authors.initials: B
authors.lastname: Davoust
authors.forename: Oleg
authors.initials: O
authors.lastname: Mediannikov
authors.forename: Jeanne
authors.initials: J
authors.lastname: Chene
authors.forename: Raphaël
authors.initials: R
authors.lastname: Massot
authors.forename: Raphaël
authors.initials: R
authors.lastname: Tine
authors.forename: Mamadou
authors.initials: M
authors.lastname: Diarra
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Demoncheaux
authors.forename: Pierre
authors.initials: P
authors.lastname: Scandola
authors.forename: Frédéric
authors.initials: F
authors.lastname: Beugnet
authors.forename: Luc
authors.initials: L
authors.lastname: Chabanne
mesh_terms: D000818:Animals; D001096:Arachnid Vectors / Q000382:microbiology; D004283:Dog Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use; D041061:Ehrlichia canis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D016873:Ehrlichiosis / Q000662:veterinary*; D005260:Female; D005798:Genes, Bacterial; D005843:Geography; D008297:Male; D015995:Prevalence; D012337:RNA, Ribosomal, 18S; D012703:Serotyping; D013987:Ticks / Q000382:microbiology
chemical_list: D012337:RNA, Ribosomal, 18S; D004318:Doxycycline
keywords: (S)-methoprene; Amitraz; Anaplasma platys; Dog; Doxycycline; Ehrlichia canis; Fipronil; PCR; Senegal; Serology