title: A prototype direct-detection CCD for protein crystallography.
abstract: The fabrication and testing of a prototype deep-depletion direct-conversion X-ray CCD detector are described. The device is fabricated on 600 µm-thick high-resistivity silicon, with 24 × 24 µm pixels in a 4k × 4k pixel format. Calibration measurements and the results of initial protein crystallography experiments at the Cornell High Energy Synchrotron Source (CHESS) F1 beamline are described, as well as suggested improvements for future versions of the detector.
authors.affiliation: Department of Physics, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Green
authors.forename: Doletha M E
authors.initials: DM
authors.lastname: Szebenyi
authors.forename: Kasey
authors.initials: K
authors.lastname: Boggs
authors.forename: Richard
authors.initials: R
authors.lastname: Bredthauer
authors.forename: Mark W
authors.initials: MW
authors.lastname: Tate
authors.forename: Sol M
authors.initials: SM
authors.lastname: Gruner
keywords: CCD area detectors; instrumentation; protein crystallography
references.citation: Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):72-82
references.pmid: 16369096
references.citation: J Synchrotron Radiat. 2011 Mar;18(Pt 2):157-64
references.pmid: 21335901
references.citation: Curr Opin Struct Biol. 2012 Oct;22(5):602-12
references.pmid: 23021872
references.citation: Acta Crystallogr D Biol Crystallogr. 1994 Nov 1;50(Pt 6):813-25
references.pmid: 15299348
references.citation: J Synchrotron Radiat. 2006 Mar;13(Pt 2):120-30
references.pmid: 16495612
references.citation: Nature. 2011 Feb 3;470(7332):73-7
references.pmid: 21293373
references.citation: Rev Sci Instrum. 2009 Aug;80(8):083302
references.pmid: 19725646
references.citation: J Synchrotron Radiat. 2006 Jan;13(Pt 1):74-84
references.pmid: 16371711