title: Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp.
abstract: Three new xanthones, 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone (1), 1-hydroxy-5- methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone (2), and 1-hydroxy-3-hydroxyethyl- 8-ethoxycarbonylxanthone (3), along with seven known xanthones (4-10) were isolated from the fermentation products of an endophytic fungus Phomopsis sp.. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1-10 were also tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) by MTT method using paclitaxel as positive control. Compounds 1 and 3 showed cytotoxicity against A549 cell lines with IC50 values of 3.6 and 2.5 μM, respectively. In addition, 1 was cytotoxic to MCF7 cells with IC50 value of 2.7 μM.
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Yang
authors.affiliation: Clinical Laboratory, First People's Hospital of Yunnan Province, Kunming 650032, PR China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Gao
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China.
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Niu
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China.
authors.forename: Li-Yin
authors.initials: LY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China. Electronic address: dugang2006@aliyun.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China. Electronic address: huqiufena@aliyun.com.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001203:Ascomycota / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D060026:Endophytes / Q000737:chemistry; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C000588649:1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone; C000588650:1-hydroxy-3-hydroxyethyl-8-ethoxycarbonylxanthone; D000970:Antineoplastic Agents; D001688:Biological Products; D044004:Xanthones
keywords: 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone;1-hydroxy-5-methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone;1-hydroxy-3-hydroxyethyl-8-ethoxycarbonylxanthone; 1,7-dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)xanthone;1-hydroxy-4,7-dimethoxy-6-(3-oxobutyl) xanthone; 6-O- methyl-2-deprenylrheediaxanthone B; Asperxanthone (PubChem CID: 5748546); Cytotoxicity; Phomopsis sp; Pinselin (PubChem CID: 5377796); Secosterigmatocystin; Structure elucidation; Xanthones