title: Thermoresponsive biodegradable HEMA-lactate-Dextran-co-NIPA cryogels for controlled release of simvastatin.
abstract: Abstract NIPA and HEMA-lactate-Dextran-based biodegradable and thermoresponsive cryogels were synthesized at different compositions by cryogelation. Chemical and morphological properties of the HEMA-lactate-Dextran-co-NIPA cryogel matrices were demonstrated by FTIR, SEM, and ESEM. Thermoresponsivity of the prepared cryogels was investigated by DSC, imaging NMR, and swelling studies. For possible use of the cryogels in potential bone tissue engineering applications, either hydrophobic simvastatin was embedded, or hydrophilic simvastatin was incorporated in the cryogels. Release profiles of simvastatin delivering cryogel scaffolds depending on their composition, hydrophobicity or hydrophilicity of loaded simvastatin and the medium temperature were demonstrated.
authors.affiliation: Engineering Faculty, Chemical Engineering Department, Mersin University , Mersin , Turkey.
authors.forename: Nimet
authors.initials: N
authors.lastname: Bölgen
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Aguilar
authors.forename: Maria del Mar
authors.initials: Mdel M
authors.lastname: Fernández
authors.forename: Sandra
authors.initials: S
authors.lastname: Gonzalo-Flores
authors.forename: Silvia
authors.initials: S
authors.lastname: Villar-Rodil
authors.forename: Julio
authors.initials: J
authors.lastname: San Román
authors.forename: Erhan
authors.initials: E
authors.lastname: Pişkin
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000924:Anticholesteremic Agents / Q000737:chemistry*; D059985:Cryogels / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D004339:Drug Compounding; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D019821:Simvastatin / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D000178:Acrylamides; D000924:Anticholesteremic Agents; D059985:Cryogels; D003692:Delayed-Action Preparations; D003911:Dextrans; D008689:Methacrylates; D011108:Polymers; D012996:Solutions; D019344:Lactic Acid; C005044:hydroxyethyl methacrylate; D019821:Simvastatin; C067295:N-isopropylacrylamide
keywords: biodegradable; cryogels; drug release; thermoresponsive