title: Genetic polymorphism of tumor necrosis factor promoter region and susceptibility to develop Hodgkin lymphoma in a Mexican population.
abstract: Hodgkin lymphoma (HL) is a rare neoplasm of the lymphatic system, in which inflammation and allelic variants in cytokines have been proposed as etiological factors. Epstein-Barr virus infection is often associated as a risk factor in HL and since cytokines are involved in the humoral response to viral infection. Our aim was to study the association between single nucleotide polymorphisms (SNPs) located in the tumor necrosis factor (TNF) gene (- 376G> A, - 238G> A and 581G> A) in a sample of Mexican patients (56 cases) and their susceptibility to develop HL, comparing these SNPs among healthy individuals (127 controls). Frequencies for TNF - 238G> A and TNF 581G> A showed no significant differences between cases and controls. However, the proportion of cases with the GA genotype of - 376 SNP showed a significant difference as compared to controls, odds ratio = 4.41 (95% confidence interval: 1.21-16.6), p = 0.02. We found that in this group of patients from Mexico the SNP - 376G> A in TNF shows an association with higher risk for HL.
authors.affiliation: PhD Graduate Program in Biological Sciences, National Autonomous University of Mexico , Mexico City , Mexico.
authors.forename: Luz María
authors.initials: LM
authors.lastname: Torres-Espíndola
authors.forename: Rafael
authors.initials: R
authors.lastname: Velázquez-Cruz
authors.forename: Ramcés
authors.initials: R
authors.lastname: Falfán-Valencia
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Chavez-Pacheco
authors.forename: Mauricio
authors.initials: M
authors.lastname: Salcedo-Vargas
authors.forename: María
authors.initials: M
authors.lastname: de Jesús Nambo-Lucio
authors.forename: Citaltepetl
authors.initials: C
authors.lastname: Salinas-Lara
authors.forename: Radames
authors.initials: R
authors.lastname: Alemón-Medina
authors.forename: Julio
authors.initials: J
authors.lastname: Granados-Montiel
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Reyes-Servín
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Manuel
authors.initials: M
authors.lastname: de Jesús Castillejos-López
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006689:Hodgkin Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Hodgkin lymphoma; TNF; allelic variants