title: Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization.
abstract: Polycystic ovary syndrome (PCOS) has been suggested to be linked with autoimmune processes. Laparoscopic ovarian electrocauterization has the potency to stimulate more autoimmune reactions in PCOS patients. In the present study, we considered anti-nuclear antibodies (ANAs) as the hallmark of autoimmune reactions, and investigated the serum level of these antibodies in 35 patients with PCOS (21-38 years old) pre and one-month after electrocauterization, and in 35 fertile healthy women (25-35 years old) as the control group. Serum levels of ANAs, as well as ANA subtyping, were investigated using the Enzyme-Linked Immunosorbent Assay (ELISA). While 3 out of the 35 patients (8.6%) were positive for ANAs before electrocauterization, none of the controls was positive. The number of ANA-positive cases increased following electrocauterization (3 out of 35 [8.6%] before vs. 10 out of 35 [28.6%] after the procedure). The main ANA subtype in the positive samples was SS-A. The higher ANA level among the PCOS patients suggests association of the disease with autoimmune reactions. Laparoscopic ovarian electrocauterization seems to increase the number of positive-ANA patients.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Alamtaj
authors.initials: A
authors.lastname: Samsami Dehaghani
authors.forename: Nazanin
authors.initials: N
authors.lastname: Karimaghaei
authors.forename: Mohammad Ebrahim
authors.initials: ME
authors.lastname: Parsanezhad
authors.forename: Mahyar
authors.initials: M
authors.lastname: Malekzadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mehrazmay
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Erfani
keywords: Anti-nuclear autoantibodie; Laparoscopic ovarian; Polycystic ovary syndrome
references.citation: Adv Hematol. 2012;2012:384685
references.pmid: 23008717
references.citation: Fertil Steril. 2009 Apr;91(4):1159-63
references.pmid: 18439597
references.citation: Gynecol Endocrinol. 2010 Apr;26(4):281-96
references.pmid: 20141388
references.citation: J Autoimmun. 2008 Feb-Mar;30(1-2):5-11
references.pmid: 18194728
references.citation: Mediators Inflamm. 2011;2011:389317
references.pmid: 21547256
references.citation: Hum Reprod. 2004 Jan;19(1):41-7
references.pmid: 14688154
references.citation: Gynecol Endocrinol. 2007 May;23(5):252-6
references.pmid: 17558682
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2745-9
references.pmid: 15181052
references.citation: Methods. 2008 Mar;44(3):205-21
references.pmid: 18314051
references.citation: Eur J Intern Med. 2010 Oct;21(5):369-71
references.pmid: 20816585
references.citation: J Reprod Immunol. 2001 Aug;51(2):167-76
references.pmid: 11543855
references.citation: Obstet Gynecol. 2002 Feb;99(2):347-58
references.pmid: 11814521
references.citation: Fertil Steril. 2010 May 1;93(7):2291-4
references.pmid: 19296936
references.citation: Eur J Endocrinol. 2004 Mar;150(3):363-9
references.pmid: 15012623
references.citation: Arch Gynecol Obstet. 2012 Mar;285(3):853-6
references.pmid: 21866332