title: Female sex hormones are associated with the reduction of serum sodium and hypertension complications in patients with aldosterone-producing adenoma.
abstract: This study was conducted to evaluate gender-related differences in clinical characteristics and vascular complications in patients with aldosterone-producing adenomas (APA). Clinical characteristics, biochemical markers and incidence of vascular complications were compared by gender in 187 consecutive patients with APA confirmed by pathological diagnosis. Patients were separated into two groups based on ages either older or younger than 49 years, the average age of menopause among Chinese women (<49 y and ≥49 y). Males had significantly higher BMI than females in the age group of <49 years (p = 0.017). In the <49 years group, males had significantly higher serum sodium levels (p = 0.003). However, no such gender differences in clinical characteristics were observed in patients ≥49 years. A higher proportion of vascular complications was observed in males as compared to females aged <49 years but the difference was not statistically significant (51.4% vs. 34.8%, p = 0.105). The only gender difference observed in vascular complications between patients aged ≥49 years was that a significantly greater proportion of males had cerebrovascular complication compared to females (p = 0.006). Our data suggest that female sex hormones are implicated in reducing serum sodium concentration and vascular complications in female APA patients.
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, PR China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Lu
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Zhu
authors.forename: Zhi-qing
authors.initials: ZQ
authors.lastname: Tang
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Du
authors.forename: Xian-Ling
authors.initials: XL
authors.lastname: Wang
authors.forename: Jin-Zhi Ou
authors.initials: JZ
authors.lastname: Yang
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Gu
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Guo
authors.forename: Nan
authors.initials: N
authors.lastname: Jin
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yang
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Ba
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Dou
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Mu
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000378:metabolism* / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000601:surgery; D000315:Adrenalectomy; D000450:Aldosterone / Q000096:biosynthesis / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000453:epidemiology / Q000378:metabolism; D006973:Hypertension / Q000453:epidemiology* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012189:Retrospective Studies; D012727:Sex Characteristics; D017678:Sex Distribution; D012737:Sex Factors; D012964:Sodium / Q000097:blood*; D014652:Vascular Diseases / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D012739:Gonadal Steroid Hormones; D000450:Aldosterone; D012964:Sodium; D011188:Potassium