title: Immediate Implant Placement in a Patient With Osteoporosis Undergoing Bisphosphonate Therapy: 1-Year Preliminary Prospective Study.
abstract: The purposes of this preliminary study are to assess the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a patient with osteoporosis using zoledronic acid and to report the results of a 1-year prospective clinical study regarding 5 immediately inserted implants in the anterior mandible. For this comparative prospective study, 24 female patients, aged ≥54 years, were chosen, all with partially edentulous mandibles. Group A consisted of 12 patients with osteoporosis taking zoledronic acid receiving a once-yearly intravenous infusion of zoledronic acid (5 mg). Control group B consisted of 12 other patients without osteoporosis and not taking drugs. In both groups, the remaining teeth were extracted before 120 implants, 3.7-mm wide and 16-mm long, were immediately installed in the interforaminal region of the mandibles. The 1-year implant survival rate was 100%. No apparent necrotic bone was observed among patients receiving zoledronic acid (group A) after implant surgery. Immediate implant osseointegration can be successful in a patient with osteoporosis using bisphosphonates, suggesting the safety of implantology as a treatment modality.
authors.affiliation: Department for Oral Surgery, Jessenius Faculty of Medicine, University of Komensky, Martin, Slovakia.
authors.forename: Tomas
authors.initials: T
authors.lastname: Siebert
authors.affiliation: Department for Oral Surgery, Jessenius Faculty of Medicine, University of Komensky, Martin, Slovakia.
authors.forename: Richard
authors.initials: R
authors.lastname: Jurkovic
authors.affiliation: Department for Oral Surgery, Jessenius Faculty of Medicine, University of Komensky, Martin, Slovakia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Statelova
authors.affiliation: Department for Oral Surgery, Jessenius Faculty of Medicine, University of Komensky, Martin, Slovakia.
authors.forename: Juraj
authors.initials: J
authors.lastname: Strecha
mesh_terms: D016301:Alveolar Bone Loss / Q000145:classification; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008334:Mandible / Q000601:surgery; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: bisphosphonate-related osteonecrosis of the jaw; immediate implant placement; mandible; osteoporosis