title: Fluid restriction and prophylactic indomethacin in extremely low birth weight infants.
abstract: Although survival of extremely low birth weight (ELBW) infants dramatically improved over last decades, bronchopulmonary dysplasia (BPD) rate has not changed. The use of indomethacin prophylaxis in ELBW infants results in improved short-term outcomes with no effect on long-term outcomes. The addition of fluid restriction to the indomethacin prophylaxis policy could result in a reduction of BPD and improve long-term survival without neurosensory impairment at 18 months corrected age. To determine the effect of a policy of fluid restriction compared with a policy of no fluid restriction on morbidity and mortality in ELBW infants receiving indomethacin prophylaxis. The standard search strategy for the Cochrane Neonatal Review Group was used. This included search of OVID MEDLINE-National Library of Medicine, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 8, 2011). Additional search included conference proceedings, references in articles, and unpublished data. All randomized or quasi-randomized trials that compared fluid restriction and indomethacin prophylaxis vs. indomethacin prophylaxis alone in ELBW infants were included. Standard methods of the Cochrane Neonatal Review Group were planned to assess the methodological quality of the trials. Review Manager 5 software was planned to be used for statistical analysis. We found no randomized controlled trials to investigate the possible interaction between fluid restriction and indomethacin prophylaxis vs. indomethacin prophylaxis alone in ELBW infants. A well-designed randomized trial is needed to address this question.
authors.affiliation: Neonatal Care, Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.
authors.forename: Jasim A
authors.initials: JA
authors.lastname: Anabrees
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Aifaleh
keywords: Extremely low birth weight infants; fluid restriction; indomethacin
references.citation: Cochrane Database Syst Rev. 2001;(3):CD000503
references.pmid: 11686962
references.citation: Pediatr Clin North Am. 1986 Feb;33(1):179-201
references.pmid: 3081865
references.citation: J Pediatr. 2006 Jun;148(6):730-734
references.pmid: 16769377
references.citation: Pediatrics. 1984 Jul;74(1):127-33
references.pmid: 6547526
references.citation: Arch Ophthalmol. 2005 Jul;123(7):991-9
references.pmid: 16009843
references.citation: Pediatrics. 2001 Jan;107(1):E1
references.pmid: 11134465
references.citation: J Pediatr. 1979 Nov;95(5 Pt 2):865-6
references.pmid: 490263
references.citation: N Engl J Med. 2001 Jun 28;344(26):1966-72
references.pmid: 11430325
references.citation: Cochrane Database Syst Rev. 2002;(3):CD000174
references.pmid: 12137607
references.citation: J Pediatr. 2005 Dec;147(6):786-90
references.pmid: 16356432
references.citation: Semin Neonatol. 2003 Feb;8(1):63-71
references.pmid: 12667831
references.citation: Pediatrics. 1961 Aug;28:169-81
references.pmid: 13702099
references.citation: Pediatrics. 1988 Jul;82(1):50-8
references.pmid: 3288958
references.citation: BMJ. 2005 Mar 12;330(7491):594-6
references.pmid: 15761002
references.citation: Pediatrics. 1988 Oct;82(4):527-32
references.pmid: 3174313
references.citation: Pediatrics. 2008 Feb;121(2):e233-8
references.pmid: 18245398
references.citation: J Pediatr. 1978 Apr;92(4):529-34
references.pmid: 305471
references.citation: J Pediatr. 2007 Jan;150(1):46-50.e2
references.pmid: 17188612
references.citation: J Pediatr. 1992 Jan;120(1):99-106
references.pmid: 1731034
references.citation: Pediatrics. 2005 Aug;116(2):333-41
references.pmid: 16061586
references.citation: JAMA. 2003 May 21;289(19):2554-9
references.pmid: 12759327
references.citation: Arch Dis Child Fetal Neonatal Ed. 2000 Jan;82(1):F24-8
references.pmid: 10634837
references.citation: Acta Paediatr Suppl. 1957 Jan;46(suppl 110):1-68
references.pmid: 13410594
references.citation: Acta Paediatr Scand Suppl. 1989;360:37-42
references.pmid: 2642254
references.citation: Am J Dis Child. 1983 Mar;137(3):215-9
references.pmid: 6823919
references.citation: N Engl J Med. 1980 Mar 13;302(11):598-604
references.pmid: 7351906
references.citation: J Pediatr. 1990 Jun;116(6):942-9
references.pmid: 2189976
references.citation: Ann Surg. 1978 Jan;187(1):1-7
references.pmid: 413500