title: Does prolidase indicate worsening of hepatitis B infection?
abstract: BACKGROUND
  Hepatitis B infection is a health problem that affects more than 400 million people all over the world. We aimed to evaluate the usability of prolidase enzyme that plays an important role in collagen synthesis. Prolidase levels increase in hepatic damage, which can be used as diagnostic parameters in the progressions to chronic hepatitis B (CHB) infection by evaluating it in different clinical forms of hepatitis B infection.
  
  
  METHODS
  A total of 69 patients who presented to our clinic with chronic hepatitis B (CHB) infection, 72 patients with inactive hepatitis B infection (IHB), and 45 healthy volunteers were included into this study. Alanine transaminase (ALT), Aspartate aminotransferase (AST) and prolidase levels of patients were measured. Hepatic biopsy was performed in patients with CHB infection. Prolidase levels were evaluated in three different groups, and its correlations with fibrosis were investigated.
  
  
  RESULTS
  Prolidase was different between all groups (P < 0.001). Prolidase level was found to be higher in CHB and IHB compared to the control group. There was no correlation between this enzyme, fibrosis, and histological activity index.
  
  
  CONCLUSIONS
  In this present study, it is shown that prolidase levels increase in hepatitis B infection. It may be used as a biochemical marker in the chronic hepatitis B.
authors.affiliation: Department of Infectious Disease and Clinic Microbiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Fazilet
authors.initials: F
authors.lastname: Duygu
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Aysegul Copur
authors.initials: AC
authors.lastname: Cicek
authors.forename: Ilknur
authors.initials: I
authors.lastname: Butun
authors.forename: Sebnem
authors.initials: S
authors.lastname: Unlu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003094:Collagen / Q000378:metabolism; D004150:Dipeptidases / Q000097:blood*; D018450:Disease Progression; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008103:Liver Cirrhosis / Q000175:diagnosis; D008297:Male; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003094:Collagen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: chronic hepatitis B; inactive hepatitis B; prolidase
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