title: Vitamin D and the heart.
abstract: Vitamin D receptors (VDR) are found in cells throughout the cardiovascular system. A variety of experimental studies indicate that the liganded VDR may play an important role in controlling cardiac hypertrophy and fibrosis, regulating blood pressure, and suppressing the development of atherosclerosis. Some, but not all, observational studies in humans provide support for these experimental findings, raising the possibility that vitamin D or its analogs might prove useful therapeutically in the prevention or treatment of cardiovascular disease.
authors.affiliation: Diabetes Center, University of California at San Francisco, San Francisco, California; and.
authors.forename: David G
authors.initials: DG
authors.lastname: Gardner
authors.forename: Songcang
authors.initials: S
authors.lastname: Chen
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Glenn
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008024:Ligands; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D018167:Receptors, Calcitriol / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014807:Vitamin D / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D008024:Ligands; D018167:Receptors, Calcitriol; D014807:Vitamin D
keywords: heart; vitamin D
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