title: [Genetics of sudden unexplained death].
abstract: Sudden unexplained death is defined by death without a conclusive diagnosis after autopsy and it is responsible for a large percentage of sudden deaths. The progressive interaction between genetics and forensics in post-mortem studies has identified inheritable alterations responsible for pathologies associated with arrhythmic sudden death. The genetic diagnosis of the deceased enables the undertaking of preventive measures in family members, many of them asymptomatic but at risk. The implications of this multidisciplinary translational medical approach are complex, requiring the dedication of a specialized team.
authors.affiliation: Centro de Genética Cardiovascular, IdIBGi-Universitat de Girona, Girona, España.
authors.forename: Oscar
authors.initials: O
authors.lastname: Campuzano
authors.affiliation: Centro de Genética Cardiovascular, IdIBGi-Universitat de Girona, Girona, España.
authors.forename: Catarina
authors.initials: C
authors.lastname: Allegue
authors.affiliation: Centro de Genética Cardiovascular, IdIBGi-Universitat de Girona, Girona, España. Electronic address: ramon@brugada.org.
authors.forename: Ramon
authors.initials: R
authors.lastname: Brugada
mesh_terms: D001344:Autopsy; D053447:Channelopathies / Q000235:genetics; D003645:Death, Sudden / Q000209:etiology*; D016757:Death, Sudden, Cardiac / Q000209:etiology; D005192:Family Health; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics; D010348:Patient Care Team; D017422:Sequence Analysis, DNA; D017180:Tachycardia, Ventricular / Q000235:genetics; D057170:Translational Research, Biomedical; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
keywords: Canalopatías; Channelopathies; Genetics; Genética; Muerte súbita inexplicada; Sudden unexplained death