title: Diffusion-weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-off values.
abstract: OBJECTIVE
  We retrospectively evaluated the usefulness of the apparent diffusion coefficient (ADC) measured from high-b value diffusion-weighted imaging (DWI) of magnetic resonance imaging for the differential diagnosis of gallbladder lesions among patients with cancer, adenoma and inflammatory disease.
  
  
  METHODS
  Forty patients with gallbladder lesions (22 patients with cancer, 7 patients with adenoma, and 11 patients with inflammatory disease) were enrolled in this study. All patients underwent high-b value DWI, and the ADC value was measured. The cut-off values were determined by receiver operating characteristic analysis.
  
  
  RESULTS
  The ADC values of gallbladder cancers (1.31±0.57x10-3 mm2/s) were smallest and those of adenomas (2.66±0.43x10-3 mm2/s) were largest among the diseases. Inflammatory diseases took a middle position (1.97±0.54x10-3 mm2/s) between them. There were significant differences among the 3 groups of diseases (p<0.05). The cut-off value within ADC values to discriminate cancer from the other diseases was 1.64x10-3 mm2/s (accuracy 87.5%), and that to discriminate adenoma was 2.25x10-3 mm2/s (accuracy 90.0%).
  
  
  CONCLUSIONS
  The ADC values measured from high-b value DWI would be useful for the differential diagnosis of gallbladder lesions.
authors.affiliation: Departments of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Go
authors.initials: G
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchinami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyazawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Abe
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishiyama
authors.forename: Manabu
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D005705:Gallbladder Diseases / Q000175:diagnosis* / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA