title: Levan as a new additive for colon-specific films: a new approach in the use of exopolysaccharides in time-dependent free films (Aminoalkyl Methacrylate Copolymer RS).
abstract: Time-dependent films, augmented with prebiotics, offer potential strategy for colon-specific controlled drug release. In this study, we produced films containing levan (L) and Aminoalkyl Methacrylate Copolymer RS (ER). Free films of ER combined with levan were produced by the casting process and characterized by the mobility of the polymeric matrix, hydration, differential scanning calorimetry (DSC) and thermogravimetry (TGA). The results of this study suggest that the exopolysaccharide levan can be used in combination with ER for colon specific materials. No evidence of incompatibilities between the levan and the synthetic polymer were detected, and levan improved the mobility of the polymeric matrix and the hydrophilicity of the system. Levan may have positively altered the density of the polymeric matrix, as visualized by thermal characterization. The endothermic decomposition peak was shifted with increasing amounts of levan. This new barrier polymer utilized a combination of time-dependent enzymatic mechanisms and can be considered promising for use in the coating of solid oral drugs for specific release.
authors.affiliation: Department of Biochemistry and Biotechnology, Center of Exact Sciences, State University of Londrina, SC, Londrina, PR, Brazil.
authors.forename: Leandro Freire
authors.initials: LF
authors.lastname: dos-Santos
authors.forename: Edgardo Alfonso
authors.initials: EA
authors.lastname: Gómez-Pineda
authors.forename: Maria Antonia-Pedrine
authors.initials: MA
authors.lastname: Colabone-Celligoi
authors.forename: Osvaldo Albuquerque
authors.initials: OA
authors.lastname: Cavalcanti
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003106:Colon; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005630:Fructans / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005630:Fructans; D008689:Methacrylates; D011135:Polysaccharides, Bacterial; D014867:Water; C072599:levan