title: Effects of supplementation with fish oil and n-3 PUFAs enriched egg yolk phospholipids on anhedonic-like response and body weight in the rat chronic mild stress model of depression.
abstract: Polyunsaturated fatty acids play an important role in the human organism. They guarantee a normal function of nervous cells, influence neurotransmission, and build some elements of cellular membranes. Several reports indicate an association between a deficiency of polyunsaturated fatty acids and depression. The aim of this study was to examine the effects of diet supplemented with fish oil, which is rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) and n-3 PUFAs enriched phospholipids ("super lecithin") obtained from designed eggs on anhedonic-like response and body weight in the rat chronic mild stress (CMS) model of depression. The results showed that neither fish oil nor n-3 PUFAs enriched egg yolk phospholipids supplementation reversed disturbances caused by CMS, such as anhedonic-like state or reduction of body weight gain.
authors.affiliation: Department of Pharmacology, Medical University, Wroclaw, Poland. maria.rutkowska@am.wroc.pl
authors.forename: M
authors.initials: M
authors.lastname: Rutkowska
authors.forename: M
authors.initials: M
authors.lastname: Trocha
authors.forename: M
authors.initials: M
authors.lastname: Szandruk
authors.forename: W
authors.initials: W
authors.lastname: Słupski
authors.forename: J
authors.initials: J
authors.lastname: Rymaszewska
mesh_terms: D000704:Analysis of Variance; D059445:Anhedonia; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003863:Depression / Q000473:pathology* / Q000523:psychology*; D004032:Diet; D019587:Dietary Supplements; D004530:Egg Yolk / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D054709:Lecithins / Q000494:pharmacology; D008297:Male; D010743:Phospholipids / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy* / Q000523:psychology*
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D054709:Lecithins; D010743:Phospholipids