title: Corneal imaging of intrastromal femtosecond laser treatment for presbyopia (Intracor(®)).
abstract: OBJECTIVE
  To evaluate anatomic appearance and corneal cellular modifications after monocular Intracor(®) procedure with two different anterior segment imaging techniques within the first postoperative year.
  
  
  METHODS
  Four patients underwent an Intracor(®) procedure in one eye performed at Clinique de la vision, and corneal imaging was performed in Quinze-Vingts National Ophthalmology Hospital. Slit-lamp photography, confocal microscopy with Heidelberg retinal tomography (HRT) and anterior segment spectral-domain optical coherence tomography (OCT) were performed 2 days, and 1, 6, and 12 months after the procedure.
  
  
  RESULTS
  Confocal microscopy showed strong cellular activation of keratocytes within the first postoperative month which diminished over time. The linear femtosecond incisions appeared as hyper-reflective regular lines and reflectivity decreased throughout the follow-up period. After 6 months, a fibrotic process with appearance of corneal scars was visible as small intrastromal hyper-reflective lines and thick hyper-reflective spicules around the incisions and remained stable over time. On spectral-domain OCT, the size and depth of the incisions decreased from the center to the periphery. Visibility of the corneal femtosecond incisions on OCT decreased from day 2 until they almost disappeared at 12 months. The incision angles seemed to curve progressively from the center to the periphery in their deep portion on the peripheral rings.
  
  
  CONCLUSIONS
  Corneal cellular modifications found on HRT, anatomical features, and the sizes of the intrastromal rings, may provide valuable information on this new refractive technique.
authors.affiliation: Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, 28, rue de Charenton, 75012 Paris, France; Clinical Investigation Center (CIC) 503, Quinze-Vingts National Ophthalmology Hospital, 28, rue de Charenton, 75012 Paris, France. Electronic address: trinhdinhliem@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Trinh
authors.forename: M
authors.initials: M
authors.lastname: Francoz
authors.forename: D
authors.initials: D
authors.lastname: Chong-Sit
authors.forename: A
authors.initials: A
authors.lastname: Labbé
authors.forename: S
authors.initials: S
authors.lastname: Dupont-Monod
authors.forename: C
authors.initials: C
authors.lastname: Baudouin
mesh_terms: D000368:Aged; D003315:Cornea / Q000473:pathology / Q000601:surgery*; D003319:Corneal Stroma / Q000601:surgery; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011305:Presbyopia / Q000175:diagnosis* / Q000473:pathology / Q000534:rehabilitation / Q000601:surgery*; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: Confocal microscopy; Intracor(®); Kératocytes; OCT spectral-domain; Presbyopia; Presbytie; SD-OCT