title: A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles.
abstract: The CF3SO3H-promoted ring opening of gem-difluorocyclopropyl ketones prefers to undergo proximal bond cleavage and the subsequent cyclization with nitriles occurred smoothly to give 2-fluoropyrroles.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. jchxiao@sioc.ac.cn.
authors.forename: Tang-Po
authors.initials: TP
authors.lastname: Yang
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Lin
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Chen
authors.forename: Ji-Chang
authors.initials: JC
authors.lastname: Xiao
mesh_terms: D018360:Crystallography, X-Ray; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D009570:Nitriles; D011758:Pyrroles