title: pHocal adhesion kinase regulation is on a FERM foundation.
abstract: Increases in intracellular pH (pHi) occur upon integrin receptor binding to matrix proteins and in tumor cells. In this issue, Choi et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. This model of FAK activation could contribute to motility of tumor cells by promoting focal adhesion turnover.
authors.affiliation: Department of Reproductive Medicine, Moores UCSD Cancer Center, La Jolla, CA 92093.
authors.forename: Christine
authors.initials: C
authors.lastname: Lawson
authors.forename: David D
authors.initials: DD
authors.lastname: Schlaepfer
mesh_terms: D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D022001:Focal Adhesions / Q000502:physiology*; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D000074082:Sodium-Hydrogen Exchanger 1; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*
chemical_list: D027682:Cation Transport Proteins; C490997:Slc9a1 protein, mouse; D000074082:Sodium-Hydrogen Exchanger 1; D017923:Sodium-Hydrogen Exchangers; D006639:Histidine; D051417:Focal Adhesion Kinase 1; C496051:Ptk2 protein, mouse
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