title: Preeclamptic cord blood hemolysis and the effect of Monascus purpureus and Saccharomyces cerevisiae in modulating preeclamptic stress.
abstract: BACKGROUND
  Preeclampsia is associated with impaired antioxidant defense that results in materno- fetal complications. In addition to antioxidant deficiency, hemolytic disorder has also been observed in preeclamptic mother.
  
  
  METHODS
  This study aims in analyzing the fetal complications using cord blood RBC (red blood cell); further the antihemolytic and antioxidant efficiency of two common probiotic yeasts Monascus purpureus and Saccharomyces cerevisiae in preeclamptic and normotensive RBCs were assessed.
  
  
  RESULTS
  There was a significant decrease in the antioxidant status (p<0.05) with increased oxidative stress, nitrative stress (p<0.05) and hemolysis (p<0.001) in preeclamptic RBC comparatively. M. purpureus demonstrated a highly significant reactive oxygen radical scavenging activity (p<0.001) whereas S. cerevisiae exhibited a highly significant nitric oxide radical scavenging activity (p<0.001). It was noted that oxidative stress hemolysis was decreased with increased antioxidant level in cord blood RBC from both samples after incubation with both yeasts in a similar manner. The antihemolytic property of M. purpureus and S. cerevisiae suggests that S. cerevisiae functions efficiently with increasing stress.
  
  
  CONCLUSIONS
  This study demonstrates for the first time that despite their differential scavenging activities, a diet rich in M. purpureus and S. cerevisiae could equally serve as a good natural supplement to alleviate the stress status in the preeclamptic fetus (Tab. 4, Fig. 1, Ref. 39).
authors.forename: P
authors.initials: P
authors.lastname: Ekambaram
authors.forename: T
authors.initials: T
authors.lastname: Jayachandran
authors.forename: U
authors.initials: U
authors.lastname: Venkatraman
authors.forename: S
authors.initials: S
authors.lastname: Leonard
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D004912:Erythrocytes; D005260:Female; D005312:Fetal Blood; D006461:Hemolysis; D006801:Humans; D032741:Monascus / Q000502:physiology*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000378:metabolism; D011247:Pregnancy; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D055815:Young Adult