title: [Changes in plasma levels of atrial natriuretic peptide, endothelin-1 and von Willebrand factor among newborns with persistent pulmonary hypertension].
abstract: OBJECTIVE
  To investigate the changes in plasma levels of atrial natriuretic peptide (ANP), endothelin-1 (ET-1) and von Willebrand factor (vWF), and their significance among newborns with persistent pulmonary hypertension (PPH).
  
  
  METHODS
  Sixty-six newborns with PPH (case group) (mild: 26 cases; moderate: 21 cases; severe: 19 cases), as well as 40 newborns without PPH (control group) who were hospitalized in the same period, were enrolled. The control group underwent echocardiography on admission. The case group underwent echocardiography before treatment (with refractory hypoxemia) and after 7 days of treatment for measurement of pulmonary artery systolic pressure (PASP). Meanwhile, plasma levels of ANP, ET-1 and vWF were measured using ELISA.
  
  
  RESULTS
  Before treatment, the case group had significantly higher plasma levels of ANP, ET-1 and vWF than the control group (P<0.05), and these indices increased as PASP rose. After 7 days of treatment, the children with mild or moderate PPH showed normal PASP, and their plasma levels of ANP, ET-1 and vWF were not significantly different from those of control group. The children with severe PPH had significant decreases in all indices, but they were significantly higher than those of the control group. Plasma levels of ANP, ET-1 and vWF were significantly positively correlated with PASP before and after treatment (P<0.01).
  
  
  CONCLUSIONS
  Changes in plasma levels of ANP, ET-1 and vWF can reflect PASP in newborns with PPH during treatment. Dynamic monitoring of these indices can help to judge the severity of PPH and guide treatment.
authors.affiliation: Department of Neonatology, Maternal and Child Health Care Hospital of Baoding, Baoding 071000, China. aimin5019081@126.com.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Yao
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Hao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xue-Jiang
authors.initials: XJ
authors.lastname: Sun
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jian-Ling
authors.initials: JL
authors.lastname: Li
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000097:blood* / Q000503:physiopathology; D011651:Pulmonary Artery / Q000503:physiopathology; D013599:Systole; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D019332:Endothelin-1; D014841:von Willebrand Factor; D009320:Atrial Natriuretic Factor