title: Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.
abstract: Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one's genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.
authors.affiliation: Department of Urology, University of California at San Francisco, 1450 3 Street, San Francisco, CA 94158, USA.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Reese
authors.forename: Jill
authors.initials: J
authors.lastname: Hardin
authors.forename: Iona
authors.initials: I
authors.lastname: Cheng
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.forename: John S
authors.initials: JS
authors.lastname: Witte
keywords: aspirin; genetic variation; non-steroidal anti-inflammatory agents; prostatic neoplasms; single nucleotide polymorphism
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