title: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Izawa
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Isobe
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsukawa
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ito
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Akie
authors.initials: A
authors.lastname: Maehara
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamanishi
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Kaitani
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan; Division of Stem Cell Signaling, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Oki
authors.affiliation: Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan; Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Okumura
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan; Division of Stem Cell Signaling, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address: kitamura@ims.u-tokyo.ac.jp.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. Electronic address: kitaura-tky@umin.ac.jp.
authors.forename: Jiro
authors.initials: J
authors.lastname: Kitaura
mesh_terms: D000818:Animals; D015550:Cell Degranulation; D002460:Cell Line; D002518:Ceramides / Q000494:pharmacology*; D025461:Feedback, Physiological; D006801:Humans; D008024:Ligands; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology; D015202:Protein Engineering; D017455:Receptors, IgE / Q000378:metabolism; D011971:Receptors, Immunologic / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D013109:Sphingomyelins / Q000494:pharmacology*; D019076:Transgenes / Q000235:genetics
chemical_list: C519443:CD300LF protein, human; D002518:Ceramides; C475664:FCER1A protein, human; D008024:Ligands; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D013109:Sphingomyelins