title: Relationship between oxidant and antioxidant activity in hyperemesis gravidarum.
abstract: OBJECTIVE
  To evaluate oxidant and antioxidant activity in patients with hyperemesis gravidarum (HG) by using serum total antioxidant activity (TAO), total free sulfhydryl (-SH), ceruloplasmin and lipid hydroperoxide (LOOH) levels.
  
  
  METHODS
  In a cross-sectional trial, blood samples were collected from patients with HG (n = 25) and healthy pregnant women (n = 25) as control group. Serum TAO activities, -SH levels and LOOH levels and ceruloplasmin levels were measured.
  
  
  RESULTS
  Serum TAO activity was found to be significantly lower (p = 0.003) in patients with HG compared with controls. However, serum -SH levels, LOOH levels and ceruloplasmin levels did not change significantly in patients with HG compared to controls.
  
  
  CONCLUSIONS
  Presence of oxidative stress in HG patients depends more on reduced antioxidant activities than increased oxidative stress.
authors.affiliation: Obstetrics and Gynecology Department, Turgut Ozal University Medical School , Ankara , Turkey and.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Onaran
authors.forename: Hasan
authors.initials: H
authors.lastname: Kafali
authors.forename: Candan İltemir
authors.initials: Cİ
authors.lastname: Duvan
authors.forename: Esra
authors.initials: E
authors.lastname: Keskin
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy; D013438:Sulfhydryl Compounds / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D016877:Oxidants; D013438:Sulfhydryl Compounds; D002570:Ceruloplasmin