title: Antidyslipidemic and antioxidant activity of an unusual amino acid (2-amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea.
abstract: In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226001, U.P., India.
authors.forename: Janki
authors.initials: J
authors.lastname: Prasad
authors.forename: Vinay Kr
authors.initials: VK
authors.lastname: Singh
authors.forename: Atul
authors.initials: A
authors.lastname: Shrivastava
authors.forename: Upma
authors.initials: U
authors.lastname: Chaturvedi
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: K R
authors.initials: KR
authors.lastname: Arya
authors.forename: S K
authors.initials: SK
authors.lastname: Awasthi
authors.forename: T
authors.initials: T
authors.lastname: Narender
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002208:Caproates / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029864:Crotalaria / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012639:Seeds / Q000737:chemistry
chemical_list: C000589571:2-amino-5-hydroxyhexanoic acid; D000975:Antioxidants; D002208:Caproates; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts
keywords: Antidyslipidemic activity; Antioxidant activity; Crotalaria juncea; Triton model