title: [Diagnosis and treatment of acute ischemic stroke].
abstract: In Japan, stroke is a major cause of death and serious long-lasting neurological disabilities. Recently, the diagnosis and treatment of ischemic stroke has changed greatly. 1) Patients with TIA are more susceptible to ischemic stroke, and the susceptibility is predicted by the ABCD2score. 2) Brain natriuretic peptide (BNP) is a hormone released from the ventricular myocardium; BNP levels can predict new atrial fibrillation during hospitalization in patients with acute ischemic stroke. 3) In Japan, thrombolysis with intravenous recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke was approved in 2004, and the time window was extended up to 4.5 h in 2012. 4) Several novel oral anticoagulants (NOAC) have been developed over the last decade; the early initiation of NOACs in acute stroke and TIA patients with nonvalvular atrial fibrillation may be safe. More evidence-based treatment for stroke in Japanese people should be established.
authors.affiliation: Department of Stroke Medicine, Kawasaki Medical School.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Shibazaki
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D020097:Natriuretic Peptide, Brain / Q000627:therapeutic use*; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D020097:Natriuretic Peptide, Brain; D010959:Tissue Plasminogen Activator