title: Time dependence of cisplatin-induced duplex dissociation of 15-mer RNAs and mature miR-146a.
abstract: The kinetics for the binding of cisplatin to duplex RNAs, two fully complementary model systems and mature miR-146a, exhibits a linear dependence on cisplatin concentration and results in duplex dissociation at 38 °C.
authors.affiliation: Biochemistry and Structural Biology, KILU, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden. sofi.elmroth@biochemistry.lu.se.
authors.forename: Christopher
authors.initials: C
authors.lastname: Polonyi
authors.forename: Sofi K C
authors.initials: SK
authors.lastname: Elmroth
mesh_terms: D002945:Cisplatin / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D035683:MicroRNAs / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D012330:RNA, Double-Stranded; D012313:RNA; D002945:Cisplatin