title: Type 2 diabetes-induced cardiovascular complications: comparative evaluation of spironolactone, atenolol, metoprolol, ramipril and perindopril.
abstract: The present study was carried out to study the effect of spironolactone, atenolol, metoprolol, ramipril and perindopril on cardiovascular complications in neonatal model of diabetes in rats, induced by administering 90 mg/kg streptozotocin (STZ), i.p. in 2-day-old rats. Our data suggest that spironolactone, metoprolol and perindopril prevent not only the STZ-induced metabolic abnormalities but also cardiovascular complications as evident from the reduction in cholesterol, triglyceride and decrease in cardiac hypertrophy which are the initial symptoms of congestive heart failure. Metoprolol and perindopril appears to be beneficial agents as compared to atenolol and ramipril.
authors.affiliation: Department of Pharmacology, Institute of Pharmacy, Nirma University, Chharodi, Ahmadabad , Gujarat , India.
authors.forename: Bhoomika M
authors.initials: BM
authors.lastname: Patel
authors.forename: Shraddha V
authors.initials: SV
authors.lastname: Bhadada
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D008790:Metoprolol / Q000494:pharmacology*; D020913:Perindopril / Q000494:pharmacology*; D017257:Ramipril / Q000494:pharmacology*; D017208:Rats, Wistar; D013148:Spironolactone / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D013148:Spironolactone; D001262:Atenolol; D008790:Metoprolol; D017257:Ramipril; D020913:Perindopril
keywords: Anti-hypertensives; cardiovascular complications; metoprolol; perindopril; spironolactone; type 2 diabetes mellitus