title: Apolipoprotein M T-778C polymorphism is associated with serum lipid levels and the risk of coronary artery disease in the Chinese population: a meta-analysis.
abstract: BACKGROUND
  The apolipoprotein M (APOM) T-778C gene polymorphism has been associated with serum lipid levels and the risk of coronary artery disease (CAD), but the results are inconclusive. The purpose of this meta-analysis was to detect the association between the APOM T-778C polymorphism and serum lipid levels and the risk of CAD in the Chinese population.
  
  
  METHODS
  Databases of MEDLINE, EMBASE, the Cochrane Library and CNKI were systematically searched. Data were extracted using standardized methods. The association was assessed by mean difference (MD) with 95% confidence intervals (CI) or odds ratio (OR) with 95% CI.
  
  
  RESULTS
  Ten studies with 4,413 patients were included in this meta-analysis. Pooled effects indicated that CT+CC group had higher levels of total cholesterol (TC) (MD:-0.36, 95% CI: -0.53 - -0.19, P < 0.0001) and low-density lipoprotein cholesterol (LDL-C) (MD: -0.08, 95% CI: -0.16 - -0.01, P = 0.03) than TT group. There was no difference in the levels of triglyceride (MD: 0.06, 95% CI: -0.04 - 0.15, P = 0.22) and high-density lipoprotein cholesterol (MD: 0.00, 95% CI: -0.03-0.03, P = 0.93) between TT and CT+CC groups. Pooled effects showed that CAD group had higher CT+CC genotype frequency than control group (OR: 1.97, 95% CI: 1.62-2.39, P < 0.00001; heterogeneity test x(2) = 2.96, P = 0.71, I(2) = 0%).
  
  
  CONCLUSIONS
  The results of the current meta-analysis show that the CT+CC group has higher levels of TC and LDL-C than the TT group. Moreover, there is also a prominent association between APOM T-778C polymorphism and the risk of CAD in the Chinese population, the CT+CC genotype is associated with increased risk of CAD.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People's Republic of China. yinruixing@163.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Guang
authors.initials: G
authors.lastname: Chu
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
mesh_terms: D000483:Alleles; D001053:Apolipoproteins / Q000097:blood / Q000235:genetics*; D000075243:Apolipoproteins M; D044466:Asian People; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016206:Databases, Bibliographic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D054834:Lipocalins / Q000097:blood / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D054834:Lipocalins; D014280:Triglycerides
references.citation: Circulation. 1998 May 12;97(18):1837-47
references.pmid: 9603539
references.citation: Ann Intern Med. 2005 Jan 18;142(2):95-104
references.pmid: 15657157
references.citation: N Engl J Med. 1981 Jan 8;304(2):65-70
references.pmid: 7442730
references.citation: Circulation. 2004 Nov 9;110(19):3068-74
references.pmid: 15505088
references.citation: N Engl J Med. 1993 Apr 22;328(16):1150-6
references.pmid: 8455681
references.citation: Clin Biochem. 2007 Oct;40(15):1108-12
references.pmid: 17674965
references.citation: Nat Genet. 2003 Feb;33(2):177-82
references.pmid: 12524541
references.citation: J Mol Neurosci. 2011 Mar;43(3):370-5
references.pmid: 20872094
references.citation: J Cardiovasc Risk. 1996 Apr;3(2):213-9
references.pmid: 8836866
references.citation: Nat Med. 2005 Apr;11(4):418-22
references.pmid: 15793583
references.citation: Lipids Health Dis. 2004 Oct 04;3:21
references.pmid: 15461812
references.citation: Br Heart J. 1986 Sep;56(3):206-12
references.pmid: 3092846
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120
references.citation: J Biol Chem. 1999 Oct 29;274(44):31286-90
references.pmid: 10531326
references.citation: Clin Biochem. 2009 Jan;42(1-2):17-21
references.pmid: 19007767
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: N Engl J Med. 1996 Apr 4;334(14):884-90
references.pmid: 8596571
references.citation: Int J Gen Med. 2009 Dec 29;2:177-82
references.pmid: 20360902
references.citation: JAMA. 1986 Nov 28;256(20):2835-8
references.pmid: 3773200
references.citation: J Lipid Res. 2007 Dec;48(12):2673-81
references.pmid: 17890682
references.citation: Am J Cardiol. 1992 Apr 15;69(12):1015-21
references.pmid: 1561971
references.citation: Diabetes Metab Res Rev. 2007 Jan;23(1):21-5
references.pmid: 16572495
references.citation: Genome Res. 2003 Dec;13(12):2621-36
references.pmid: 14656967
references.citation: Curr Opin Lipidol. 2006 Apr;17(2):139-51
references.pmid: 16531750