title: New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules.
abstract: Recent investigations have rekindled interest in 8-hydroxyquinolines as therapeutic agents for cancer, Alzheimer's disease, and other neurodegenerative disorders. Three new β-cyclodextrin conjugates of 8-hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress.
authors.affiliation: Dipartimento di Scienze Chimiche, University of Catania, Viale A. Doria 6, 95125 Catania (Italy); Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex BN1 9QJ (UK).
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.forename: Antonino
authors.initials: A
authors.lastname: Puglisi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Viale
authors.forename: Cinzia
authors.initials: C
authors.lastname: Aiello
authors.forename: Carmelo
authors.initials: C
authors.lastname: Sgarlata
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
authors.forename: James
authors.initials: J
authors.lastname: Clarke
authors.forename: John
authors.initials: J
authors.lastname: Milton
authors.forename: John
authors.initials: J
authors.lastname: Spencer
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D003300:Copper / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D006001:Glycoconjugates / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry* / Q000627:therapeutic use; D018384:Oxidative Stress; D015125:Oxyquinoline / Q000737:chemistry*; D012995:Solubility; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D015032:Zinc / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D056831:Coordination Complexes; D003505:Cyclodextrins; D006001:Glycoconjugates; D008024:Ligands; D008670:Metals; D015125:Oxyquinoline; D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc
keywords: antioxidants; chelating agents; copper; glycoconjugates; zinc