title: Design, synthesis and cytotoxic activity evaluation of new aminosubstituted benzofurans.
abstract: A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-activity relationships.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Daniilides
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Lougiakis
authors.forename: Nicole
authors.initials: N
authors.lastname: Pouli
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Marakos
authors.forename: Pinelopi
authors.initials: P
authors.lastname: Samara
authors.affiliation: University of Athens, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Panepistimiopolis- Zografou, Athens 15771, Greece. marakos@pharm.uoa.gr.
authors.forename: Ourania
authors.initials: O
authors.lastname: Tsitsilonis
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans