title: The developmental origins of adipose tissue.
abstract: Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.
authors.affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Berry
authors.forename: Drew
authors.initials: D
authors.lastname: Stenesen
authors.forename: Daniel
authors.initials: D
authors.lastname: Zeve
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Graff
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D055153:Stem Cell Niche / Q000502:physiology; D013234:Stem Cells / Q000166:cytology
keywords: Adipocyte; Adipose; Development; Niche; Stem cells; Vascular niche
references.citation: Cell Metab. 2012 Feb 8;15(2):230-9
references.pmid: 22326224
references.citation: J Clin Invest. 1973 Apr;52(4):929-41
references.pmid: 4693656
references.citation: Trends Endocrinol Metab. 2002 Jan-Feb;13(1):5-11
references.pmid: 11750856
references.citation: J Lipid Res. 2012 Feb;53(2):227-46
references.pmid: 22140268
references.citation: Plast Reconstr Surg. 2012 Jun;129(6):1277-1290
references.pmid: 22634645
references.citation: Nat Med. 2010 Dec;16(12):1400-6
references.pmid: 21102460
references.citation: Genes Dev. 2009 Apr 1;23(7):788-97
references.pmid: 19339685
references.citation: Cell Metab. 2008 May;7(5):410-20
references.pmid: 18460332
references.citation: Nat Med. 2013 May;19(5):631-4
references.pmid: 23603813
references.citation: Circ Res. 2009 Jun 19;104(12):1410-20
references.pmid: 19443841
references.citation: J Biol Chem. 2000 Sep 15;275(37):28488-93
references.pmid: 10862772
references.citation: Growth. 1978 Dec;42(4):469-77
references.pmid: 750310
references.citation: Cell Metab. 2012 Apr 4;15(4):480-91
references.pmid: 22482730
references.citation: Cell. 2001 Feb 23;104(4):531-43
references.pmid: 11239410
references.citation: Cell Metab. 2011 Jul 6;14(1):116-22
references.pmid: 21723509
references.citation: Science. 2001 Dec 7;294(5549):2166-70
references.pmid: 11739957
references.citation: Science. 2000 Aug 11;289(5481):950-3
references.pmid: 10937998
references.citation: Proc Soc Exp Biol Med. 1983 Nov;174(2):258-64
references.pmid: 6634719
references.citation: Exp Nephrol. 2001;9(3):191-7
references.pmid: 11340303
references.citation: FASEB J. 2006 Jul;20(9):1540-2
references.pmid: 16754744
references.citation: Nat Med. 2013 May;19(5):635-9
references.pmid: 23603815
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6676-81
references.pmid: 16617105
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7
references.pmid: 14660788
references.citation: J Clin Invest. 2006 Dec;116(12):3220-8
references.pmid: 17143331
references.citation: Metabolism. 1971 Oct;20(10):927-35
references.pmid: 5097682
references.citation: Cell Metab. 2006 Jan;3(1):25-34
references.pmid: 16399502
references.citation: Cell Metab. 2012 Apr 4;15(4):492-504
references.pmid: 22482731
references.citation: Cell. 2012 Jul 20;150(2):366-76
references.pmid: 22796012
references.citation: Diabetes. 2001 Aug;50(8):1863-71
references.pmid: 11473050
references.citation: Mol Cell Biochem. 2002 Oct;239(1-2):95-100
references.pmid: 12479574
references.citation: Trends Endocrinol Metab. 2012 Feb;23(2):56-64
references.pmid: 22079269
references.citation: Am J Clin Nutr. 1984 Apr;39(4):631-7
references.pmid: 6711470
references.citation: Sci Rep. 2011;1:81
references.pmid: 22355600
references.citation: Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34
references.pmid: 21952300
references.citation: Nature. 2008 Aug 21;454(7207):1000-4
references.pmid: 18719589
references.citation: PLoS One. 2012;7(5):e36569
references.pmid: 22574183
references.citation: N Engl J Med. 2007 Jan 18;356(3):213-5
references.pmid: 17229948
references.citation: Endocrinology. 1994 Aug;135(2):798-800
references.pmid: 8033830
references.citation: J Clin Invest. 2000 Feb;105(3):287-92
references.pmid: 10675354
references.citation: Development. 2007 Jun;134(12):2283-92
references.pmid: 17507398
references.citation: N Engl J Med. 2004 Sep 9;351(11):1106-18
references.pmid: 15356308
references.citation: J Clin Invest. 2007 Sep;117(9):2362-8
references.pmid: 17786229
references.citation: Diabetes. 2006 May;55(5):1353-60
references.pmid: 16644692
references.citation: Microcirculation. 1997 Jun;4(2):211-32
references.pmid: 9219215
references.citation: Am J Clin Nutr. 2003 May;77(5):1192-7
references.pmid: 12716671
references.citation: J Clin Invest. 2009 Jan;119(1):110-24
references.pmid: 19065047
references.citation: Diabetes. 2007 Jun;56(6):1517-26
references.pmid: 17389330
references.citation: J Biol Chem. 2004 Aug 20;279(34):35503-9
references.pmid: 15190075
references.citation: Neurosci Biobehav Rev. 2001 Jan;25(1):15-28
references.pmid: 11166075
references.citation: Physiol Rev. 2004 Jan;84(1):277-359
references.pmid: 14715917
references.citation: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307
references.pmid: 16985259
references.citation: Endocrinology. 1993 Jul;133(1):352-9
references.pmid: 8319581
references.citation: PLoS One. 2008 May 14;3(5):e2152
references.pmid: 18478054
references.citation: Science. 2008 Oct 24;322(5901):583-6
references.pmid: 18801968
references.citation: J Clin Invest. 1998 Mar 15;101(6):1354-61
references.pmid: 9502777
references.citation: J Dermatol Sci. 2007 Oct;48(1):43-52
references.pmid: 17644316
references.citation: Annu Rev Biochem. 2008;77:289-312
references.pmid: 18518822
references.citation: Diabetes Care. 1998 Sep;21(9):1470-4
references.pmid: 9727893
references.citation: Curr Opin Pharmacol. 2004 Jun;4(3):281-9
references.pmid: 15140421
references.citation: Physiol Rev. 1998 Jul;78(3):783-809
references.pmid: 9674695
references.citation: Cell. 2007 Oct 19;131(2):242-56
references.pmid: 17956727
references.citation: Diabetologia. 2000 Dec;43(12):1498-506
references.pmid: 11151758
references.citation: Clin Endocrinol Metab. 1976 Jul;5(2):299-311
references.pmid: 1085232
references.citation: Mol Cell. 1999 Oct;4(4):585-95
references.pmid: 10549290
references.citation: Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1056-64
references.pmid: 18728224
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5874-9
references.pmid: 22451920
references.citation: Circ Res. 2003 Oct 31;93(9):e88-97
references.pmid: 14525808
references.citation: Development. 2011 Nov;138(22):5027-37
references.pmid: 22028034
references.citation: Genes Dev. 1994 May 15;8(10):1224-34
references.pmid: 7926726
references.citation: Cell Death Differ. 2007 Jul;14(7):1361-73
references.pmid: 17464333
references.citation: Dev Biol. 2006 Aug 1;296(1):164-76
references.pmid: 16730693
references.citation: Endocr Rev. 2011 Jun;32(3):387-403
references.pmid: 21173384
references.citation: Cell Metab. 2007 Sep;6(3):195-207
references.pmid: 17767906
references.citation: Genes Dev. 1996 Apr 15;10(8):974-84
references.pmid: 8608944
references.citation: Dev Cell. 2003 Jan;4(1):131-42
references.pmid: 12530969
references.citation: Nat Med. 2012 Mar 06;18(3):363-74
references.pmid: 22395709
references.citation: J Clin Invest. 2007 Mar;117(3):812-22
references.pmid: 17304352
references.citation: Diabetes Care. 2000 Aug;23(8):1067-71
references.pmid: 10937499
references.citation: Exp Hematol. 2009 Sep;37(9):1108-20, 1120.e1-4
references.pmid: 19576951
references.citation: J Cell Biol. 1985 Oct;101(4):1227-35
references.pmid: 3900088
references.citation: Annu Rev Cell Dev Biol. 2000;16:145-71
references.pmid: 11031233
references.citation: Stem Cells Dev. 2009 Apr;18(3):457-63
references.pmid: 18690793
references.citation: Eur Rev Med Pharmacol Sci. 2012 Mar;16(3):393-406
references.pmid: 22530358
references.citation: Nature. 2008 Jun 5;453(7196):783-7
references.pmid: 18454136
references.citation: Diabetes. 2012 May;61(5):1112-21
references.pmid: 22396202
references.citation: Diabetes. 2007 Dec;56(12):2910-8
references.pmid: 17848624
references.citation: Obes Res. 2003 Jan;11(1):104-11
references.pmid: 12529492
references.citation: J Embryol Exp Morphol. 1975 Aug;34(1):125-54
references.pmid: 1185098
references.citation: J Physiol Sci. 2011 Jan;61(1):55-63
references.pmid: 21140253
references.citation: Nat Cell Biol. 2013 Mar;15(3):302-8
references.pmid: 23434825
references.citation: Trends Mol Med. 2011 Aug;17(8):405-11
references.pmid: 21602104
references.citation: Cell. 2008 Oct 17;135(2):240-9
references.pmid: 18835024
references.citation: Acta Pathol Microbiol Scand. 1961;51:347-53
references.pmid: 13713150
references.citation: Cell Metab. 2012 Sep 5;16(3):348-62
references.pmid: 22940198
references.citation: Mol Endocrinol. 2009 Nov;23(11):1717-25
references.pmid: 19541743
references.citation: Diabetes Care. 1999 Feb;22(2):288-93
references.pmid: 10333947
references.citation: Cell Metab. 2010 Apr 7;11(4):257-62
references.pmid: 20374957
references.citation: PLoS One. 2011 Mar 02;6(3):e17637
references.pmid: 21407813
references.citation: N Engl J Med. 2009 Apr 9;360(15):1509-17
references.pmid: 19357406
references.citation: J Cell Physiol. 1988 Jan;134(1):124-30
references.pmid: 3275678
references.citation: Acta Pharmacol Sin. 2012 Feb;33(2):155-72
references.pmid: 22301856
references.citation: Mol Cell Biochem. 1987 Jul;76(1):35-43
references.pmid: 3627113
references.citation: Stem Cells. 2009 Oct;27(10):2563-70
references.pmid: 19658193
references.citation: J Clin Invest. 1969 Nov;47(11):2485-98
references.pmid: 4304653
references.citation: Nature. 2008 Aug 21;454(7207):961-7
references.pmid: 18719582
references.citation: J Cell Biol. 1963 Sep;18:663-79
references.pmid: 14064115
references.citation: Diabetes. 2012 Jul;61(7):1691-9
references.pmid: 22596050
references.citation: Cell Metab. 2012 Feb 8;15(2):222-9
references.pmid: 22326223
references.citation: J Nutr. 2006 Dec;136(12):2953-6
references.pmid: 17116701
references.citation: Physiol Behav. 2009 May 25;97(2):199-204
references.pmid: 19250944
references.citation: Anat Rec. 1963 Oct;147:273-93
references.pmid: 14065939
references.citation: Cell. 1975 May;5(1):19-27
references.pmid: 165899
references.citation: Cell Stem Cell. 2009 Nov 6;5(5):472-81
references.pmid: 19896439
references.citation: Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1286-96
references.pmid: 11959668
references.citation: Am J Physiol. 1993 Jun;264(6 Pt 1):C1600-8
references.pmid: 8333508