title: The relationship of a family history for hypertension, myocardial infarction, or stroke with cardiovascular physiology in young women.
abstract: Cardiovascular disease (CVD) and preeclampsia share several pathophysiologic risk factors. We examined family history (FH) and physiologic status in 60 healthy, nulliparous women to determine the relationship between FH and known risk factors for CVD. Data are presented as mean ± standard error (SE). Decreased uterine blood flow was observed in women with FH of hypertension (+FH: 21.5 ± 1.7, no FH: 33.3 ± 9.0 mL/min; P = .04). Women reporting an FH of stroke showed increased alpha- and beta-adrenergic response, as measured by Valsalva maneuver (α: FH: 24.7 ± 1.9, -FH: 18.9 ± 1.1 mm Hg, P = .02; β: FH: 22.0 ± 2.1, -FH: 16.9 ± 1.4 mm Hg; P = .04), and increased cardiac output (4.83 ± 0.22 vs 4.31 ± 0.12 L/min; P = .01). We identified no significant physiologic associations linked to an FH of myocardial infarction. Our observations show significant differences in physiologic characteristics in women with specific CVD family histories. These data, coupled with known heritable contributions to CVD and preeclampsia, suggest a distinct physiologic phenotype that may link preeclampsia risk with FH of CVD, independent of pregnancy.
authors.affiliation: 1University of Vermont, Departments of Obstetrics, Gynecology and Reproductive Sciences, Burlington, VT, USA.
authors.forename: Carole A
authors.initials: CA
authors.lastname: McBride
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Hale
authors.forename: Meenakumari
authors.initials: M
authors.lastname: Subramanian
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Badger
authors.forename: Ira M
authors.initials: IM
authors.lastname: Bernstein
mesh_terms: D000322:Adrenergic Agonists / Q000494:pharmacology; D000328:Adult; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D002302:Cardiac Output; D005260:Female; D020022:Genetic Predisposition to Disease; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D010641:Phenotype; D012039:Regional Blood Flow; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D055988:Uterine Artery / Q000502:physiology*; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D000322:Adrenergic Agonists
keywords: family history; hypertension; plasma volume; preeclampsia; stroke
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