title: Methyl 3-[(chloro-meth-oxy)carbon-yloxy]-7-hy-droxy-cholan-24-oate.
abstract: The title compound, C27H43ClO6, is a derivative of urso-deoxy-cholic acid, in which the OH group at the 3-position is substituted by a chloro-meth-oxy-carbon-yloxy substituent and the carb-oxy-lic acid group at the 24-position is methyl-ated. The A and B rings are cis-fused, while all other rings are trans-fused. In the crystal, two adjacent mol-ecules located along the b-axis direction are inter-locked head-to-tail due to weak C-H⋯O hydrogen bonds. Therefore each mol-ecule is linked to four neighbouring mol-ecules by four C-H⋯O hydrogen bonds, with the OH group at the 7-position and the carbonyl O atom of the ester group acting as the acceptor sites.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, People's Republic of China.
authors.forename: Jia-Liang
authors.initials: JL
authors.lastname: Zhong
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Sun
authors.forename: Fu-Li
authors.initials: FL
authors.lastname: Zhang
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Liu
authors.forename: He
authors.initials: H
authors.lastname: Liu
references.citation: J Med Chem. 2004 Aug 12;47(17):4213-30
references.pmid: 15293993
references.citation: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references.pmid: 18156677