title: Comparison of propofol-dexmedetomidine, tiopental-dexmedetomidine and etomidate-dexmedetomidine combinations' effects on the tracheal intubation conditions without using muscle relaxants.
abstract: BACKGROUND
  In our study, we aimed to compare the endotracheal intubation conditions without muscle relaxants during induction with the combinations of dexmedotimidine-propofol, dexmedotimidine-thiopenthal and dexmedetomidine-etomidate.
  
  
  METHODS
  Seventy-six patients, in ASA risk group I-II, between ages 20-60 years, with Mallampati Class 1 were included in the study. All patients were premedicated with midazolam. The patients were randomly divided into three groups as Group P (n=30, dexmedetomidine-propofol), Group T (n=30, dexmedetomidine-thiopenthal), Group E (n=16, dexmedetomidine-etomidate). All patients received dexmedetomidine 1 μg.kg-1 in 10 min. Then, the patients were administered 2.5 mg.kg-1 propofol for Group P, 5 mg.kg-1 thiopental for Group T and 0.3 mg.kg-1 etomidate for Group E during induction. Hemodynamic data of the patients were recorded before induction, after dexmedetomidine administration, immediately after intubation and 3, 5 and 10 minutes after intubation.
  
  
  RESULTS
  There was no difference between the groups according to hemodynamic data. Sixteen patients in Group P and 10 patients in Group T had acceptable intubation conditions. Muscle relaxant was needed in 14, 20 and 16 patients in Groups P, T and E, respectively (p<0.05).
  
  
  CONCLUSIONS
  In conclusion, we determined that best intubation conditions without muscle relaxants were achieved with propofol-dexmedetomidine combination. None of the patients receiving etomidate -dexmedetomidine combination could be intubated without muscle relaxants (Tab. 6, Ref. 29).
authors.forename: K
authors.initials: K
authors.lastname: Bollucuoglu
authors.forename: V
authors.initials: V
authors.lastname: Hanci
authors.forename: S
authors.initials: S
authors.lastname: Yurtlu
authors.forename: D
authors.initials: D
authors.lastname: Okyay
authors.forename: H
authors.initials: H
authors.lastname: Ayoglu
authors.forename: I O
authors.initials: IO
authors.lastname: Turan
mesh_terms: D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D020927:Dexmedetomidine / Q000494:pharmacology*; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D013874:Thiopental; D015742:Propofol; D005045:Etomidate