title: [Value of dynamic arterial elastance in the predication of arterial pressure response to volume loading in shock patients].
abstract: OBJECTIVE
  To explore the value of dynamic arterial elastance (Eadyn) in the predication of arterial pressure response to volume loading in shock patients.
  
  
  METHODS
  A total of 32 patients with pulse indicator continuous cardiac output (PICCO) monitoring at our intensive care unit from January 2011 to December 2012 were retrospectively studied. The decision of fluid replacement was based upon the presence of shock (mean arterial pressure (MAP) ≤ 65 mm Hg, systolic arterial pressure <90 mm Hg or a decrease of 40 mm Hg from baseline) and preserved volume responsiveness condition with a stroke volume variation (SVV) value ≥ 10%. According to the MAP increase after volume loading, they were classified into MAP responders (≥ 15%) and MAP nonresponders (<15%) respectively. The goal was to investigate the influencing factors of the changes of MAP after volume loading and predict the arterial pressure response to volume loading.
  
  
  RESULTS
  Significantly different between MAP responders and MAP nonresponders, baseline Eadyn was an effective predictor of MAP increase after volume loading. The area under the ROC curve was 0.95 for the prediction of volume loading on MAP for Eadyn at baseline (P < 0.01). A baseline Eadyn value >0.85 predicted a MAP increase after volume administration with a sensitivity of 89.5% and a specificity of 92.3%.
  
  
  CONCLUSIONS
  Baseline Eadyn may predict accurately arterial pressure response in MAP to volume loading in shock patients.
authors.affiliation: Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Mao-lei
authors.initials: ML
authors.lastname: Gong
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Liu
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Wang
authors.forename: Xiu-kai
authors.initials: XK
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D004548:Elasticity; D005440:Fluid Therapy; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012769:Shock / Q000503:physiopathology* / Q000628:therapy*; D018924:Vascular Capacitance