title: White blood cell count in young adulthood and coronary artery calcification in early middle age: coronary artery risk development in young adults (CARDIA) study.
abstract: White blood cell (WBC) count is associated with incident coronary heart disease (CHD). Data are sparse regarding its association in young adults with future coronary artery calcification (CAC). Our study was conducted among coronary artery risk development in young adults (CARDIA) participants (n=3,094). We examined the association between baseline (Y0) WBC counts and CHD risk factors using linear regression models. We further assessed prospective associations between Y0 WBC and inflammatory biomarkers during the follow-up, and the presence of CAC 15 and 20 years later. In total, 272 and 566 subjects had CAC scores>0 at year (Y) 15 and Y20, respectively. Baseline total WBC counts were cross-sectionally associated with SBP, BMI, and smoking, or HDL-cholesterol (p≤0.01) at Y0, and prospectively associated with C-reactive protein at Y7, Y15, and Y20, and fibrinogen at Y5 and Y20 (p<0.01). After adjustment for potential confounding factors, baseline neutrophil count was borderline associated with CAC presence 15 years later (OR=1.18 per unit, 95% CI 1.00-1.44) and total WBC (OR=1.07, 95% CI 0.96-1.19) or eosinophil (OR=1.12, 95%CI 1.00-1.25) was borderline associated with CAC presence at Y20. Baseline total WBC counts in young adults was associated prospectively with CAC presence 20 years later after adjusting for age, sex, and race. Results are attenuated when other risk factors are accounted for. Our results suggest the possible early involvement of WBC, particularly eosinophils, in the early stages of atherosclerosis.
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Dr. suite 1400, Chicago, IL, 60611, USA, l-hou@northwestern.edu.
authors.forename: Lifang
authors.initials: L
authors.lastname: Hou
authors.forename: Donald M
authors.initials: DM
authors.lastname: Lloyd-Jones
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ning
authors.forename: Mark D
authors.initials: MD
authors.lastname: Huffman
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.forename: Ka
authors.initials: K
authors.lastname: He
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: David C
authors.initials: DC
authors.lastname: Goff
authors.forename: Steve
authors.initials: S
authors.lastname: Sidney
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Carr
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
references.citation: Circulation. 2009 Jan 27;119(3):382-9
references.pmid: 19139385
references.citation: J Am Coll Cardiol. 1996 Feb;27(2):277-84
references.pmid: 8557894
references.citation: JAMA. 2000 May 17;283(19):2546-51
references.pmid: 10815118
references.citation: Atherosclerosis. 2010 May;210(1):288-93
references.pmid: 19963213
references.citation: Eur J Cell Biol. 1992 Dec;59(2):352-63
references.pmid: 1493801
references.citation: Atherosclerosis. 2010 Aug;211(2):606-11
references.pmid: 20307883
references.citation: Curr Opin Lipidol. 2006 Dec;17(6):619-25
references.pmid: 17095905
references.citation: Radiology. 1994 Sep;192(3):631-6
references.pmid: 8058926
references.citation: J Investig Med. 2011 Jan;59(1):27-31
references.pmid: 21060285
references.citation: Radiology. 1994 Feb;190(2):347-52
references.pmid: 8284380
references.citation: Circ J. 2006 Jan;70(1):8-13
references.pmid: 16377917
references.citation: Circulation. 1996 Jun 1;93(11):1951-3
references.pmid: 8640967
references.citation: Circulation. 2000 Oct 31;102(18):2185-9
references.pmid: 11056090
references.citation: Am J Cardiol. 2000 Apr 15;85(8):945-8
references.pmid: 10760331
references.citation: Circulation. 2003 Dec 16;108(24):2957-63
references.pmid: 14676136
references.citation: G Ital Cardiol. 1995 Sep;25(9):1145-52
references.pmid: 8529851
references.citation: Eur J Vasc Endovasc Surg. 1996 Aug;12(2):218-22
references.pmid: 8760986
references.citation: J Gerontol. 1992 Sep;47(5):B154-8
references.pmid: 1380968
references.citation: Immunol Today. 1998 Jan;19(1):5-9
references.pmid: 9465481
references.citation: Circulation. 2005 Jun 28;111(25):3481-8
references.pmid: 15983262
references.citation: Am Heart J. 1996 Jul;132(1 Pt 1):9-12
references.pmid: 8701881
references.citation: Appl Human Sci. 1998 Nov;17(6):239-47
references.pmid: 10052221
references.citation: Circulation. 2012 Jan 3;125(1):e2-e220
references.pmid: 22179539
references.citation: Am J Epidemiol. 2001 Oct 15;154(8):758-64
references.pmid: 11590089
references.citation: Diabetes Care. 2004 Feb;27(2):491-6
references.pmid: 14747234
references.citation: N Engl J Med. 1993 Feb 4;328(5):313-8
references.pmid: 8419817
references.citation: Hypertension. 1995 Feb;25(2):155-61
references.pmid: 7843763
references.citation: Am Heart J. 2010 Sep;160(3):458-63
references.pmid: 20826253
references.citation: N Engl J Med. 1999 Jan 14;340(2):115-26
references.pmid: 9887164
references.citation: J Lipid Mediat. 1993 Mar-Apr;6(1-3):75-88
references.pmid: 8358018
references.citation: J Am Coll Cardiol. 1990 Mar 15;15(4):827-32
references.pmid: 2407762
references.citation: Am J Epidemiol. 1993 Jan 1;137(1):49-53
references.pmid: 8434572
references.citation: Atherosclerosis. 2006 May;186(1):140-5
references.pmid: 16084515
references.citation: Nephrol Dial Transplant. 2006 Apr;21(4):850-3
references.pmid: 16464884
references.citation: J Formos Med Assoc. 2003 Nov;102(11):775-81
references.pmid: 14724723
references.citation: J Pediatr. 2001 Apr;138(4):486-92
references.pmid: 11295710
references.citation: Am J Epidemiol. 1996 Jun 1;143(11):1107-15
references.pmid: 8633599
references.citation: Arch Intern Med. 2005 Mar 14;165(5):500-8
references.pmid: 15767524
references.citation: Stroke. 2007 Nov;38(11):2900-5
references.pmid: 17901385
references.citation: Int Arch Allergy Immunol. 1995;108 Suppl 1:52-4
references.pmid: 7549525
references.citation: J Am Coll Cardiol. 2004 Nov 16;44(10):1945-56
references.pmid: 15542275
references.citation: Circulation. 2003 Jan 28;107(3):499-511
references.pmid: 12551878
references.citation: Nature. 2002 Dec 19-26;420(6917):868-74
references.pmid: 12490960
references.citation: J Am Coll Cardiol. 2007 May 22;49(20):2013-20
references.pmid: 17512357
references.citation: Am J Epidemiol. 1997 Mar 1;145(5):416-21
references.pmid: 9048515
references.citation: Am J Epidemiol. 1982 Sep;116(3):496-509
references.pmid: 7124717
references.citation: Nutr Metab Cardiovasc Dis. 2007 May;17(4):319-26
references.pmid: 17110092
references.citation: Circulation. 2002 Mar 5;105(9):1135-43
references.pmid: 11877368
references.citation: J Am Coll Cardiol. 1998 Jan;31(1):126-33
references.pmid: 9426030
references.citation: J Clin Epidemiol. 1988;41(11):1105-16
references.pmid: 3204420
references.citation: Cardiovasc Res. 1998 May;38(2):516-21
references.pmid: 9709414