title: [Multi-center clinical study on the treatment of the low-middle frequency sudden hearing loss].
abstract: OBJECTIVE
  To investigate and compare the short-term outcome of patients with low-middle frequency sudden deafness treated with alone or combination treatment.
  
  
  METHODS
  From August 2007 to October 2011, 205 patients with the diagnosis of low-middle frequency sudden deafness who were from 33 different clinical centers were recruited. All patients were followed up for four weeks from the initial examination. Patients were treated with steroid , Ginaton, batroxobin respectively, or Ginaton and steroid combination treatment.
  
  
  RESULTS
  The total effective rate was 90.73%. In Ginaton group, the total effective rate was 87.27%, 89.19% in steroid group, 87.80% in batroxobin group, and 95.83% in Ginaton and steroid group. Considering the total effective rate, there was no statistical difference between four groups (χ(2) = 7.98, P = 0.54). The clinical cure rate for steroid alone was 81.01%, Ginaton alone 76.36%, batroxobin alone 68.29%, and Ginaton and steroid combination treatment 80.56%. There were no clinically significant differences between the different treatments (P > 0.05).
  
  
  CONCLUSIONS
  The low-middle frequency sudden deafness tends to have a relatively favorable prognosis. The steroid played a good effect in the treatment. But different treatments either improving the microcirculation of inner ear or alleviating edema blood has undifferentiated results. Therefore the combination therapy may be more effective.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat-Sen University, Guangzhou, China. zhengyiq@mail.sysu.edu.cn
authors.forename: Yi-qing
authors.initials: YQ
authors.lastname: Zheng
authors.forename: Yong-kang
authors.initials: YK
authors.lastname: Ou
authors.forename: Yao-dong
authors.initials: YD
authors.lastname: Xu
authors.forename: Xue-yuan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Ming-fang
authors.initials: MF
authors.lastname: Diao
authors.forename: Dong-lan
authors.initials: DL
authors.lastname: Chen
mesh_terms: D012103:Batroxobin; D002681:China / Q000453:epidemiology; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006319:Hearing Loss, Sensorineural; D003639:Hearing Loss, Sudden / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans
chemical_list: D012103:Batroxobin