title: Bisphosphonate-related osteonecrosis of the jaw in patients with breast cancer.
abstract: Bisphosphonate represents a well-established treatment option in the management of metastatic bone disease and bone loss/osteoporosis in women with breast cancer. These drugs reduce osteoclast. Some bisphosphonate also have osteoblastic function leading to a reducted bone turnover and thereby skeletal-related events. The aim of this review is to evaluate the bisphosphonate-related osteonecrosis of the jaw in patients with breast cancer. Based on the proven effect of bone protection during adjuvant endocrine therapy, new treatment guidelines recommend the routine use of bisphosphonates to prevent bone loss during adjuvant therapy, which may likely become the standard practice.
authors.affiliation: Orthopaedic Oncologic Unit, "Palazzo Baleani" Cancer Centre, Policlinico Umberto I, Rome, Italy, andrea.piccioli2013@libero.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piccioli
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
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