title: Tumour heterogeneity and cancer cell plasticity.
abstract: Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible changes in cell properties. Some cancers also contain a hierarchy in which tumorigenic cancer stem cells differentiate into non-tumorigenic progeny. However, it remains unclear what fraction of cancers follow the stem-cell model and what clinical behaviours the model explains. Studies using lineage tracing and deep sequencing could have implications for the cancer stem-cell model and may help to determine the extent to which it accounts for therapy resistance and disease progression.
authors.affiliation: Howard Hughes Medical Institute, Children's Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Corbin E
authors.initials: CE
authors.lastname: Meacham
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Morrison
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D060965:Clonal Evolution; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D018740:Genetic Heterogeneity; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000473:pathology
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