title: Dynamic construction of a coherent attentional state in a prefrontal cell population.
abstract: Prefrontal cortex has been proposed to show highly adaptive information coding, with neurons dynamically allocated to processing task-relevant information. To track this dynamic allocation in monkey prefrontal cortex, we used time-resolved measures of neural population activity in a simple case of competition between target (behaviorally critical) and nontarget objects in opposite visual hemifields. Early in processing, there were parallel responses to competing inputs, with neurons in each hemisphere dominated by the contralateral stimulus. Later, the nontarget lost control of neural activity, with emerging global control by the behaviorally critical target. The speed of transition reflected the competitive weights of different display elements, occurring most rapidly when relative behavioral significance was well established by training history. In line with adaptive coding, the results show widespread reallocation of prefrontal processing resources as an attentional focus is established.
authors.affiliation: MRC Cognition and Brain Sciences Unit, Cambridge CB2 7EF, UK. Electronic address: miki.kadohisa@psy.ox.ac.uk.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kadohisa
authors.forename: Philippe
authors.initials: P
authors.lastname: Petrov
authors.forename: Mark
authors.initials: M
authors.lastname: Stokes
authors.forename: Natasha
authors.initials: N
authors.lastname: Sigala
authors.forename: Mark
authors.initials: M
authors.lastname: Buckley
authors.forename: David
authors.initials: D
authors.lastname: Gaffan
authors.forename: Makoto
authors.initials: M
authors.lastname: Kusunoki
authors.forename: John
authors.initials: J
authors.lastname: Duncan
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D003463:Cues; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology*; D011930:Reaction Time; D013647:Task Performance and Analysis
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