title: Mutagenicity and genotoxicity in gill erythrocyte cells of Poecilia reticulata exposed to a glyphosate formulation.
abstract: Poecilia reticulata were exposed to herbicide Roundup Transorb(®) for micronucleus test, nuclear abnormalities and comet assay. The exposure-concentrations were based on CL50-96 h following 0, 1.41, 2.83, 4.24 and 5.65 μL L(-1) for 24 h. Micronucleus and comets were significantly increased in the gill erythrocyte cells after herbicide exposure compared with the non-exposed group. Results showed a gradual increase in the number of damaged cells, indicating a concentration-dependent effect and that this herbicide was mutagenic and genotoxic to P. reticulata and this effect could be attributed to a combination of compounds contained in the formulation with the active ingredient glyphosate.
authors.affiliation: Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, CEP 70919-970, Brazil.
authors.forename: José
authors.initials: J
authors.lastname: De Souza Filho
authors.forename: Caio César Neves
authors.initials: CC
authors.lastname: Sousa
authors.forename: Cláudio Carlos
authors.initials: CC
authors.lastname: Da Silva
authors.forename: Simone Maria Teixeira
authors.initials: SM
authors.lastname: De Sabóia-Morais
authors.forename: Cesar Koppe
authors.initials: CK
authors.lastname: Grisolia
mesh_terms: D000818:Animals; D020552:Comet Assay; D004912:Erythrocytes / Q000187:drug effects*; D005880:Gills / Q000166:cytology / Q000187:drug effects*; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011036:Poecilia; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000097797:Glyphosate
chemical_list: D005998:Glycine; D006540:Herbicides; D009153:Mutagens; D014874:Water Pollutants, Chemical; D000097797:Glyphosate