title: Efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis.
abstract: Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2×10(3) S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0,0004), as well as in the positive organ cultures of microorganism from the organ (p=0,0142). With these results it is possible to conclude that the antifungals studied are effective in the treatment of experimental systemic sporotrichosis.
authors.affiliation: Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brasil.
authors.forename: Ana Raquel Mano
authors.initials: AR
authors.lastname: Meinerz
authors.forename: Melissa O
authors.initials: MO
authors.lastname: Xavier
authors.forename: Marlete Brum
authors.initials: MB
authors.lastname: Cleff
authors.forename: Isabel Martins
authors.initials: IM
authors.lastname: Madrid
authors.forename: Márcia Oliveira
authors.initials: MO
authors.lastname: Nobre
authors.forename: Mário Carlos Araújo
authors.initials: MC
authors.lastname: Meireles
authors.forename: João Roberto Braga
authors.initials: JR
authors.lastname: de Mello
keywords: antifungal; itraconazole; sporotrichosis; terbinafine
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