title: Risk of suicide attempt in adopted and nonadopted offspring.
abstract: OBJECTIVE
  We asked whether adoption status represented a risk of suicide attempt for adopted and nonadopted offspring living in the United States. We also examined whether factors known to be associated with suicidal behavior would mediate the relationship between adoption status and suicide attempt.
  
  
  METHODS
  Participants were drawn from the Sibling Interaction and Behavior Study, which included 692 adopted and 540 nonadopted offspring and was conducted at the University of Minnesota from 1998 to 2008. Adoptees were systematically ascertained from records of 3 large Minnesota adoption agencies; nonadoptees were ascertained from Minnesota birth records. Outcome measures were attempted suicide, reported by parent or offspring, and factors known to be associated with suicidal behavior including psychiatric disorder symptoms, personality traits, family environment, and academic disengagement.
  
  
  RESULTS
  The odds of a reported suicide attempt were ~4 times greater in adoptees compared with nonadoptees (odds ratio: 4.23). After adjustment for factors associated with suicidal behavior, the odds of reporting a suicide attempt were reduced but remained significantly elevated (odds ratio: 3.70).
  
  
  CONCLUSIONS
  The odds for reported suicide attempt are elevated in individuals who are adopted relative to those who are not adopted. The relationship between adoption status and suicide attempt is partially mediated by factors known to be associated with suicidal behavior. Continued study of the risk of suicide attempt in adopted offspring may inform the larger investigation of suicidality in all adolescents and young adults.
authors.affiliation: Department of Psychology, University of Minnesota, 75 East River Rd, Minneapolis, MN 55455. mkeyes@umn.edu.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Keyes
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Malone
authors.forename: Anu
authors.initials: A
authors.lastname: Sharma
authors.forename: William G
authors.initials: WG
authors.lastname: Iacono
authors.forename: Matt
authors.initials: M
authors.lastname: McGue
mesh_terms: D000293:Adolescent; D000300:Adoption / Q000523:psychology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D008910:Minnesota / Q000453:epidemiology; D012307:Risk Factors; D035781:Siblings / Q000523:psychology*; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: adjustment; adoption; suicide attempt
references.citation: Psychol Med. 2000 Jan;30(1):23-39
references.pmid: 10722173
references.citation: J Child Psychol Psychiatry. 1967 May;8(1):1-11
references.pmid: 6033260
references.citation: Arch Pediatr Adolesc Med. 2008 May;162(5):419-25
references.pmid: 18458187
references.citation: Dev Psychol. 2005 Nov;41(6):971-84
references.pmid: 16351340
references.citation: Arch Gen Psychiatry. 1992 Aug;49(8):624-9
references.pmid: 1637252
references.citation: J Abnorm Child Psychol. 1993 Jun;21(3):339-53
references.pmid: 8335767
references.citation: Lancet. 2002 Aug 10;360(9331):443-8
references.pmid: 12241716
references.citation: Arch Gen Psychiatry. 1988 Dec;45(12):1069-77
references.pmid: 2848472
references.citation: JAMA. 1997 Sep 10;278(10):823-32
references.pmid: 9293990
references.citation: Pediatrics. 2001 Aug;108(2):E30
references.pmid: 11483840
references.citation: Suicide Life Threat Behav. 1999 Spring;29(1):37-47
references.pmid: 10322619
references.citation: J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):372-94
references.pmid: 16492264
references.citation: Pediatrics. 2001 Mar;107(3):485-93
references.pmid: 11230587
references.citation: Psychol Methods. 2002 Jun;7(2):147-77
references.pmid: 12090408
references.citation: Arch Gen Psychiatry. 2002 Aug;59(8):741-9
references.pmid: 12150651
references.citation: Am J Psychiatry. 2005 Mar;162(3):592-8
references.pmid: 15741478
references.citation: J Am Acad Child Adolesc Psychiatry. 1987 Sep;26(5):649-53
references.pmid: 3667494
references.citation: Dev Psychol. 1997 Mar;33(2):351-63
references.pmid: 9147842
references.citation: J Am Acad Child Adolesc Psychiatry. 1995 May;34(5):612-22
references.pmid: 7775356
references.citation: J Am Acad Child Adolesc Psychiatry. 1992 Jul;31(4):655-62
references.pmid: 1644728
references.citation: Am J Orthopsychiatry. 2003 Apr;73(2):190-202
references.pmid: 12769240
references.citation: J Am Acad Child Adolesc Psychiatry. 1999 Dec;38(12):1497-505
references.pmid: 10596249
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):59-66
references.pmid: 10638068
references.citation: Soc Psychiatry Psychiatr Epidemiol. 2006 Feb;41(2):95-102
references.pmid: 16372142
references.citation: J Epidemiol Community Health. 2004 May;58(5):412-7
references.pmid: 15082742
references.citation: JAMA. 2005 May 25;293(20):2501-15
references.pmid: 15914751
references.citation: Dev Psychol. 2006 May;42(3):514-32
references.pmid: 16756442
references.citation: Suicide Life Threat Behav. 2005 Apr;35(2):206-16
references.pmid: 15843337
references.citation: Suicide Life Threat Behav. 1995;25 Suppl:52-63
references.pmid: 8553429
references.citation: J Am Acad Child Adolesc Psychiatry. 1996 Sep;35(9):1174-82
references.pmid: 8824061
references.citation: Behav Genet. 2007 May;37(3):449-62
references.pmid: 17279339
references.citation: Soc Psychiatry Psychiatr Epidemiol. 2006 Jan;41(1):68-74
references.pmid: 16307200
references.citation: J Consult Clin Psychol. 1994 Apr;62(2):297-305
references.pmid: 8201067