title: Resveratrol derivatives: a patent review (2009 - 2012).
abstract: BACKGROUND
  There is currently a wealth of information on the effects of resveratrol and its derivatives in therapeutic, cosmetic and nutraceutical patent applications. Structure-activity studies of the resveratrol scaffold provide a foundation for the development of new analogs with potent activity or other beneficial properties. Ongoing research has yielded promising results and potential use in the treatment of various diseases.
  
  
  METHODS
  This review provides analysis of patents published from January 2009 to April 2013. There is a focus on different approaches for the production of resveratrol derivatives, combinations of new derivatives with old drugs, and applications in therapeutic areas, nutraceutical compositions and cosmetics.
  
  
  CONCLUSIONS
  The ability of resveratrol to interact with a disparate array of subcellular targets is uncanny. Nonetheless, even though limited or no toxicity is apparent, the molecule is not a panacea due to lack of potency and issues with bioavailability. Thus, as witnessed by a number of patents, a large assortment of derivatives have been synthesized under the guise of having superior characteristics for treating or preventing various diseases or for use as neutraceutics and cosmetics. Some of these suppositions are probably correct, but evidence-based applications are essentially nil due to a lack of commitment in terms of investing the resources necessary for the conduct of obligatory clinical trials. Current usage is largely based on anecdotes and publicity. Hopefully, at some point in time, it will be possible to follow a standard protocol with a predicable outcome.
authors.affiliation: University of Hawaii at Hilo, The Daniel K. Inouye College of Pharmacy , Hilo, HI 96720 , USA pezzuto@hawaii.edu.
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Tamara P
authors.initials: TP
authors.lastname: Kondratyuk
authors.forename: Talysa
authors.initials: T
authors.lastname: Ogas
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D003358:Cosmetics / Q000737:chemistry*; D019587:Dietary Supplements; D015195:Drug Design; D006801:Humans; D010330:Patents as Topic; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003358:Cosmetics; D013267:Stilbenes; D000077185:Resveratrol