title: Large solid-pseudopapillary neoplasm of the pancreas with aberrant protein expression and mutation of β-catenin: a case report and literature review of the distribution of β-catenin mutation.
abstract: Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of CTNNB1. We also present a review of the literature describing the clustering of CTNNB1 mutations in patients with SPN.
authors.affiliation: Department of Gastroenterology, Hokkaido University, Graduate School of Medicine, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mariko
authors.initials: M
authors.lastname: Ozasa
authors.forename: Kencho
authors.initials: K
authors.lastname: Miyashita
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Saga
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Miwa
authors.forename: Makoto
authors.initials: M
authors.lastname: Saito
authors.forename: Masanobu
authors.initials: M
authors.lastname: Morioka
authors.forename: Motoya
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Takenouchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yabiku
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kanno
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yuzawa
authors.forename: Mishie
authors.initials: M
authors.lastname: Tanino
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Naoya
authors.initials: N
authors.lastname: Sakamoto
mesh_terms: D015820:Cadherins / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism*; D055815:Young Adult; D051176:beta Catenin / Q000235:genetics* / Q000378:metabolism*
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin