title: Serum 25-hydroxyvitamin D predicts severity in Parkinson's disease patients.
abstract: In recent years, increasing evidence has shown that individuals with Parkinson's disease (PD) have lower levels of 25-hydroxyvitamin D [25(OH) D] relative to healthy controls. We therefore evaluated the relationship between serum 25(OH) D levels and severity in Chinese patients with a Parkinson's disease. From July 2010 to June 2012, consecutive PD patients admitted to the Department of Neurology of General Hospital, Tianjin Medical University, were identified. Clinical information and disease duration were collected. Serum level of 25(OH) D was measured at baseline. PD severity was assessed at admission using the Hoehn and Yahr (HY) stage and Unified Parkinson's Disease Rating Stage (UPDRS) total score. The results indicated that the mean serum 25(OH) D levels were significantly lower in PD patients as compared to normal cases (P < 0.001). There was a negative correlation between levels of 25(OH) D and the disease duration [r (spearman) = -0.124, P = 0.041]. There was a significant negative relationship between circulating serum 25(OH) D levels and severity of Parkinson's disease evaluated by HY stage (P = 0.030) and UPDRS Stage (P = 0.000) even after multivariate adjustment for possible confounders: age, gender, disease duration, levels of Ca, ALP, blood glucose, and seasons. These results suggest that lower 25(OH) D levels may be associated with severity of PD in Chinese patients.
authors.affiliation: Department of Neurology, General Hospital, Tianjin Medical University, No. 154, Anshandao Heping District, Tianjin, 300052, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Ben-Shu
authors.initials: BS
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D012720:Severity of Illness Index; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
references.citation: Neurology. 1997 Nov;49(5):1273-8
references.pmid: 9371907
references.citation: Mov Disord. 2012 Feb;27(2):264-71
references.pmid: 22213340
references.citation: Arch Neurol. 1999 Jan;56(1):33-9
references.pmid: 9923759
references.citation: Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2317-9
references.pmid: 21084698
references.citation: Nat Immunol. 2010 Apr;11(4):344-9
references.pmid: 20208539
references.citation: Neurology. 2000 Sep 26;55(6):888-91
references.pmid: 10994019
references.citation: Mov Disord. 2012 Jul;27(8):974-9
references.pmid: 22674432
references.citation: Nutrition. 2011 Apr;27(4):399-404
references.pmid: 20971616
references.citation: Curr Drug Targets. 2011 Jan;12(1):88-96
references.pmid: 20795935
references.citation: Am J Clin Nutr. 2013 May;97(5):1004-13
references.pmid: 23485413
references.citation: Int J Mol Epidemiol Genet. 2013;4(1):61-9
references.pmid: 23565323
references.citation: BMC Neurol. 2013 Apr 12;13:35
references.pmid: 23587062
references.citation: N Engl J Med. 2007 Jul 19;357(3):266-81
references.pmid: 17634462
references.citation: Mov Disord. 2008 Nov 15;23(15):2129-70
references.pmid: 19025984
references.citation: Mov Disord. 2005 Dec;20(12):1598-603
references.pmid: 16114020
references.citation: Lancet. 2005 Feb 12-18;365(9459):595-7
references.pmid: 15708103
references.citation: J Alzheimers Dis. 2013;33(3):659-74
references.pmid: 23042216
references.citation: Arch Neurol. 2008 Oct;65(10):1348-52
references.pmid: 18852350
references.citation: J Neurosci Res. 2012 Dec;90(12):2227-36
references.pmid: 22930493
references.citation: Kidney Int. 2006 Jan;69(1):33-43
references.pmid: 16374421
references.citation: Nutrition. 2013 Jun;29(6):828-32
references.pmid: 23415143
references.citation: Neurology. 2008 May 20;70(21):1972-9
references.pmid: 18401018
references.citation: J Neurol. 2013 Mar;260(3):754-60
references.pmid: 23052606
references.citation: Am J Epidemiol. 2006 Nov 15;164(10):998-1002
references.pmid: 16905642
references.citation: Arch Neurol. 2010 Jul;67(7):808-11
references.pmid: 20625085
references.citation: Arch Neurol. 2011 Mar;68(3):314-9
references.pmid: 21403017