title: Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report.
abstract: This is the first paper to report the association of cancer chemotherapy with rhabdomyolysis in children. A previously healthy, 15-year-old Japanese female was diagnosed as having alveolar rhabdomyosarcoma. She received the first cycle of multi-agent chemotherapy without any adverse effects. However, she developed severe acute rhabdomyolysis shortly after the second cycle of multi-agent chemotherapy, which consisted of etoposide, ifosfamide, actinomycin-D and vincristine. Her condition deteriorated rapidly and she was treated with mechanical ventilation and fluid replacement. After further evaluation, anticancer drugs were thought to be responsible for the rhabdomyolysis.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.forename: Aiko
authors.initials: A
authors.lastname: Suminoe
authors.forename: Utako
authors.initials: U
authors.lastname: Oba
authors.forename: Tomohito
authors.initials: T
authors.lastname: Takimoto
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
keywords: Acute renal failure; Chemotherapy; Child; Rhabdomyolysis; Rhabdomyosarcoma
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