title: Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling.
abstract: Colorectal cancer (CRC) is now perceived as a multistep process characterized by the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Plant-derived compounds are receiving considerable attention for their potential role in reducing cancer risk. Luteolin, a bioflavonoid present in many fruits and vegetables, possesses antioxidant, anti-inflammatory and antiproliferative properties. This study was designed to investigate the possible role of luteolin administration on Phase 1 and 2 enzymes and NF-E2-related factor 2 (Nrf2)/keap1 pathway. Male Balb/C mice were divided into four groups: normal control, Azoxymethane (AOM)-induced, AOM-induced and luteolin treated, normal control treated with luteolin. CRC was induced by administration of AOM (15 mg/kg body weight) intraperitoneally (i.p.) once a week for three weeks. Luteolin administration (1.2 mg/kg body weight/day) significantly alleviated Phase1 enzymes in colon and liver, it increased the levels of phase 2 enzymes. Luteolin modulates the expressions of GST-α, µ and also the expression of Nrf2. Collectively, results of our hypothesis show that luteolin is a novel candidate for treating CRC.
authors.affiliation: Department of Biochemistry, Cell Biology Lab, University of Madras , Chennai, Tamil Nadu , India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Pandurangan
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Ananda Sadagopan
authors.forename: Prakash
authors.initials: P
authors.lastname: Dharmalingam
authors.forename: Sudhandiran
authors.initials: S
authors.lastname: Ganapasam
mesh_terms: D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D005786:Gene Expression Regulation / Q000187:drug effects*; D047311:Luteolin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse; D047311:Luteolin; D001397:Azoxymethane