title: Gray matter is targeted in first-attack multiple sclerosis.
abstract: The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation.
authors.affiliation: Departments of Medicine, and Epidemiology and Biostatistics, Rutgers University New Jersey Medical School, Newark, New Jersey, United States of America.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Schutzer
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Angel
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Athena A
authors.initials: AA
authors.lastname: Schepmoes
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Jonas
authors.initials: J
authors.lastname: Bergquist
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
authors.forename: Denes
authors.initials: D
authors.lastname: Zadori
authors.forename: David G
authors.initials: DG
authors.lastname: Camp
authors.forename: Bart K
authors.initials: BK
authors.lastname: Holland
authors.forename: Richard D
authors.initials: RD
authors.lastname: Smith
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Coyle
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D040901:Proteomics; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D009419:Nerve Tissue Proteins
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