title: Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury.
abstract: OBJECTIVE
  Blast-induced mild traumatic brain injuries (mTBI) commonly go undetected by computed tomography and conventional magnetic resonance imaging (MRI). This study was used to investigate functional brain network abnormalities in a group of blast-induced mTBI subjects using independent component analysis (ICA) of resting state functional MRI (fMRI) data.
  
  
  METHODS
  Twenty-eight resting state networks of 13 veterans who sustained blast-induced mTBI were compared with healthy controls across three fMRI domains: blood oxygenation level-dependent spatial maps, time course spectra and functional connectivity.
  
  
  RESULTS
  The mTBI group exhibited hyperactivity in the temporo-parietal junctions and hypoactivity in the left inferior temporal gyrus. Abnormal frequencies in default-mode (DMN), sensorimotor, attentional and frontal networks were detected. In addition, functional connectivity was disrupted in six network pairs: DMN-basal ganglia, attention-sensorimotor, frontal-DMN, attention-sensorimotor, attention-frontal and sensorimotor-sensorimotor.
  
  
  CONCLUSIONS
  The results suggest white matter disruption across certain attentional networks. Additionally, given their elevated activity relative to controls', the temporo-parietal junctions of blast mTBI subjects may be compensating for diffuse axonal injury in other cortical regions.
authors.affiliation: Department of Neurology, Health Sciences Center, University of New Mexico , Albuquerque, NM , USA .
authors.forename: Andrei A
authors.initials: AA
authors.lastname: Vakhtin
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.forename: Rex E
authors.initials: RE
authors.lastname: Jung
authors.forename: Jillian L
authors.initials: JL
authors.lastname: Prestopnik
authors.forename: Paul A
authors.initials: PA
authors.lastname: Taylor
authors.forename: Corey C
authors.initials: CC
authors.lastname: Ford
mesh_terms: D000328:Adult; D001288:Attention; D001753:Blast Injuries / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001924:Brain Concussion / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D020127:Recovery of Function; D014481:United States; D014728:Veterans
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