title: BetaHCG secretion by a pulmonary adenocarcinoma.
abstract: We report a rare case of metastatic non-small-cell lung cancer in a 43-year-old woman with a history of smoking. The tumor secreted human chorionic gonadotropin and its beta subunit (BetaHCG). The patient presented with amenorrhea, a positive pregnancy test and chest pain. A physical examination and investigations revealed no pregnancy, and it was determined that a paraneoplastic syndrome stemming from a pulmonary tumor was responsible for the secretion of BetaHCG. This secretion decreased with tumor response to chemotherapy. Only a few reports of paraneoplastic BetaHCG secretion can be found in the literature for several different cancers.
authors.affiliation: Department of Medical Oncology, Institut Paoli-Calmettes, 13009 Marseille, France. cecile.vicier@gmail.com.
authors.forename: Cécile
authors.initials: C
authors.lastname: Vicier
authors.forename: Emeline
authors.initials: E
authors.lastname: Tabouret
authors.forename: Agnès
authors.initials: A
authors.lastname: Tallet
authors.forename: Anthony
authors.initials: A
authors.lastname: Gonçalves
authors.forename: Bruno
authors.initials: B
authors.lastname: Chetaille
authors.forename: Patrice
authors.initials: P
authors.lastname: Viens
authors.forename: Anne
authors.initials: A
authors.lastname: Madroszyk
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D005260:Female; D006801:Humans; D010257:Paraneoplastic Syndromes / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human
references.citation: Lung Cancer. 2006 Feb;51(2):251-5
references.pmid: 16352372
references.citation: Jpn J Clin Oncol. 2000 Mar;30(3):163-6
references.pmid: 10798545
references.citation: Bull Cancer. 2012 Nov;99(11):1065-8
references.pmid: 23017787
references.citation: Am J Med Sci. 2002 Aug;324(2):104-5
references.pmid: 12186103
references.citation: Lung Cancer. 2008 Sep;61(3):416-9
references.pmid: 18304689
references.citation: Arch Intern Med. 1993 Mar 22;153(6):746-52
references.pmid: 8383484
references.citation: Pneumologie. 2011 Jun;65(6):347-58
references.pmid: 21267813
references.citation: Mayo Clin Proc. 2010 Sep;85(9):838-54
references.pmid: 20810794
references.citation: Obstet Gynecol Surv. 2007 Oct;62(10):675-9; quiz 691
references.pmid: 17868483
references.citation: Rev Pneumol Clin. 2013 Feb;69(1):36-40
references.pmid: 23337393
references.citation: Otolaryngol Head Neck Surg. 2010 Jul;143(1):169-70
references.pmid: 20620641
references.citation: Scand J Urol Nephrol. 2008;42(6):555-7
references.pmid: 19031270
references.citation: J Biol Chem. 1980 Feb 10;255(3):1000-7
references.pmid: 7188695
references.citation: Breast J. 2009 Sep-Oct;15(5):527-30
references.pmid: 19624411
references.citation: Lancet. 2013 Jan 12;381(9861):133-41
references.pmid: 23107252