title: Assessment of volume status and arterial stiffness in chronic kidney disease.
abstract: OBJECTIVE
  There is limited information about arterial stiffness in chronic kidney disease (CKD) which is an independent risk factor for cardiovascular events. Pulse wave velocity (PWV), augmentation index (AIx) are using to determine arterial stiffness. We aimed to study PWV, AIx, volume status in patients with stage 3B-5 CKD and continuous ambulatory peritoneal dialysis (CAPD).
  
  
  METHODS
  Sixty-six stage 3B-5 CKD patients, 21 CAPD patients, 34 healthy controls were included. Pulse wave velocity, AIx, volume status was evaluated by Mobil-O-Graph®, and bioimpedance spectroscopy, respectively.
  
  
  RESULTS
  The Median PWV was 7.5 m/s in CKD, 6.2 m/s in CAPD, 5.9 m/s in healthy controls, and while PWV was found to have increased significantly in CKD patients (p = 0.002), the Alx values were similar in all groups. The median extracellular fluid excess was higher in both the CKD and, CAPD patients when compared with healthy controls (1.26 and 1.21 L, respectively). Overhydration was more prevalent in CKD and CAPD patients (p < 0.001). Age, central systolic blood pressure, body mass index, fat mass, overhydration, CKD, eGFR were the major determinants of PWV.
  
  
  CONCLUSIONS
  Increased PWV was found in stage 3B-5 CKD patients. Overhydration may contribute this increment.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University , Aydın , Turkey .
authors.forename: Hakan
authors.initials: H
authors.lastname: Akdam
authors.forename: Handan
authors.initials: H
authors.lastname: Öğünç
authors.forename: Alper
authors.initials: A
authors.lastname: Alp
authors.forename: Özgül
authors.initials: Ö
authors.lastname: Özbek
authors.forename: İmran Kurt
authors.initials: İK
authors.lastname: Ömürlü
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yeniçerioğlu
authors.forename: Harun
authors.initials: H
authors.lastname: Akar
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition; D001834:Body Water; D016022:Case-Control Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness