title: Cerebral hyperaemia after isoflurane anaesthesia for craniotomy of patients with supratentorial brain tumour.
abstract: BACKGROUND
  Few studies look into cerebral blood flow (CBF) changes during emergence from general anaesthesia for craniotomy. The purpose of this study was to assess CBF changes during emergence from general anaesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb (SjvO2 ) and transcranial Doppler (TCD).
  
  
  METHODS
  We enrolled 30 patients undergoing selective craniotomy (group C) for supratentorial brain tumour resection and 30 patients undergoing selective abdominal surgery (group A). Mean velocity of middle cerebral artery (Vmca), mean arterial pressure (MAP), SjvO2 (only measured in group C), and arterial CO2 partial pressure were measured before anaesthesia, at tracheal extubation, and 30, 60, 90, 120 min after extubation.
  
  
  RESULTS
  Vmca of the same side of tumour was significantly higher than contralateral Vmca before anaesthesia and at all times after extubation in group C. The ipsilateral Vmca increased significantly (95.7 ± 16.9 cm/s vs. 63.7 ± 6.7 cm/s, P < 0.01) at extubation in group C, then declined but still above baseline significantly in the first 2 h after extubation. While Vmca of the right side changed only slightly (63.6 ± 7.7 cm/s vs. 61.8 ± 8.1 cm/s, P < 0.01) but significantly at extubation in group A. SjvO2 increased significantly (81.4% ± 7.4% vs. 60.9% ± 3.7%, P < 0.01) at extubation in group C, and remained above baseline significantly for 2 h. There was no significant correlation between Vmca and MAP at any time.
  
  
  CONCLUSIONS
  Cerebral hyperaemia occurs after supratentorial brain tumour resection surgery. The hyperaemia is more pronounced on the same side as the tumour.
authors.affiliation: Department of Anaesthesiology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Yang
authors.forename: S-J
authors.initials: SJ
authors.lastname: Zhou
authors.forename: Y-F
authors.initials: YF
authors.lastname: Yu
authors.forename: Y-F
authors.initials: YF
authors.lastname: Shen
authors.forename: H-Z
authors.initials: HZ
authors.lastname: Xu
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation / Q000379:methods*; D062186:Arterial Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003399:Craniotomy / Q000379:methods*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000209:etiology*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D015173:Supratentorial Neoplasms / Q000503:physiopathology / Q000601:surgery*
chemical_list: D007530:Isoflurane; D010100:Oxygen