title: Relation between exhaled nitric oxide and left ventricular performance in chronic hemodialysis patients.
abstract: BACKGROUND
  End-stage renal disease is the most debilitating condition for patients with renal diseases. Cardiovascular disease is the leading cause of death in these patients. It has been shown that nitric oxide (NO) increases in renal failure and hemodialysis patients and could be correlated with cardiovascular diseases in this population.
  
  
  OBJECTIVE
  To investigate the relation between exhaled nitric oxide (eNO) and left ventricular performance in chronic hemodialysis patients.
  
  
  METHODS
  In this prospective study, eNO was measured in 20 chronic hemodialysis patients (13 males and 7 females with the mean age of 45.20 ± 14.99 years). Left ventricular findings were studied by conventional and Doppler echocardiography. eNO correlation with the echocardiographic parameters was evaluated.
  
  
  RESULTS
  The median eNO was 11.65 ppb (range: 1.9-29.9 ppb). eNO was positively correlated with left ventricular ejection fraction (ρ = 0.561, p = 0.01) and negatively correlated with left ventricular end systolic volume (ρ = -0.451, p = 0.046), isovolumic relaxation time (ρ = -0.448, p = 0.047) and myocardial performance index (ρ = -0.587, p = 0.007).
  
  
  CONCLUSIONS
  There is a positive correlation between eNO and left ventricular performance in chronic hemodialysis patients. Therefore, eNO may play an important role in pathophysiology of cardiac involvement in these patients.
authors.affiliation: Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences , Tabriz , Iran .
authors.forename: Khalil
authors.initials: K
authors.lastname: Ansarin
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Toufan
authors.forename: Hossein
authors.initials: H
authors.lastname: Namdar
authors.forename: Jalal
authors.initials: J
authors.lastname: Etemadi
authors.forename: Afshin
authors.initials: A
authors.lastname: Habibzadeh
authors.forename: Mahbuba
authors.initials: M
authors.lastname: Valinejad
authors.forename: Mohammadali M
authors.initials: MM
authors.lastname: Shoja
authors.forename: Kamyar
authors.initials: K
authors.lastname: Ghabili
mesh_terms: D000328:Adult; D001944:Breath Tests; D045853:Exhalation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis / Q000502:physiology*; D011446:Prospective Studies; D006435:Renal Dialysis; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D009569:Nitric Oxide