title: Uncovering the mysteries of  hantavirus infections.
abstract: Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic, but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology.
authors.affiliation: Department of Virology, Haartman Institute, P.O. Box 21, University of Helsinki, Finland. antti.vaheri@helsinki.fi
authors.forename: Antti
authors.initials: A
authors.lastname: Vaheri
authors.forename: Tomas
authors.initials: T
authors.lastname: Strandin
authors.forename: Jussi
authors.initials: J
authors.lastname: Hepojoki
authors.forename: Tarja
authors.initials: T
authors.lastname: Sironen
authors.forename: Heikki
authors.initials: H
authors.lastname: Henttonen
authors.forename: Satu
authors.initials: S
authors.lastname: Mäkelä
authors.forename: Jukka
authors.initials: J
authors.lastname: Mustonen
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000821:virology; D002199:Capillary Permeability; D002353:Carrier State / Q000821:virology; D042783:Endothelial Cells / Q000473:pathology / Q000821:virology; D016679:Genome, Viral; D006476:Orthohantavirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D018778:Hantavirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006801:Humans; D011991:Receptors, Virus / Q000276:immunology; D012377:Rodentia / Q000821:virology; D014158:Transcription, Genetic; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D011991:Receptors, Virus
references.citation: J Virol. 2010 May;84(9):4832-9
references.pmid: 20181715
references.citation: J Clin Virol. 2010 Jul;48(3):159-61
references.pmid: 20308016
references.citation: Clin Infect Dis. 2002 May 1;34(9):1224-31
references.pmid: 11941549
references.citation: PLoS Pathog. 2010 Feb 19;6(2):e1000779
references.pmid: 20174562
references.citation: Clin Infect Dis. 1999 Apr;28(4):834-9
references.pmid: 10825047
references.citation: Scand J Infect Dis. 2013 Jun;45(6):494-6
references.pmid: 23294035
references.citation: Arch Virol. 2013 Mar;158(3):521-9
references.pmid: 23090188
references.citation: Am J Pathol. 1995 Mar;146(3):552-79
references.pmid: 7887439
references.citation: Immunology. 2013 Oct;140(2):168-78
references.pmid: 23600567
references.citation: J Clin Invest. 1993 Jan;91(1):103-9
references.pmid: 8423210
references.citation: J Virol. 2008 Jun;82(12):5797-806
references.pmid: 18367532
references.citation: Blood Coagul Fibrinolysis. 2011 Sep;22(6):468-72
references.pmid: 21508829
references.citation: Thromb Haemost. 2009 Dec;102(6):1030-41
references.pmid: 19967132
references.citation: Virology. 2003 Feb 15;306(2):219-24
references.pmid: 12642095
references.citation: Emerg Infect Dis. 2006 Jan;12(1):166-8
references.pmid: 16494739
references.citation: J Virol. 2001 Feb;75(4):1808-15
references.pmid: 11160679
references.citation: J Clin Microbiol. 2003 Oct;41(10):4894-7
references.pmid: 14532254
references.citation: PLoS One. 2012;7(2):e31455
references.pmid: 22347483
references.citation: J Virol. 2006 Aug;80(16):8279-82
references.pmid: 16873286
references.citation: Virus Res. 2011 Dec;162(1-2):138-47
references.pmid: 21945215
references.citation: J Infect Dis. 1996 Jan;173(1):38-43
references.pmid: 8537680
references.citation: Thromb Res. 2012 May;129(5):611-5
references.pmid: 22133274
references.citation: J Virol. 2013 Jun;87(12):6975-85
references.pmid: 23576516
references.citation: Infect Genet Evol. 2010 Dec;10(8):1208-17
references.pmid: 20691810
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):804-9
references.pmid: 21187405
references.citation: J Virol. 1995 Sep;69(9):5754-62
references.pmid: 7637020
references.citation: MMWR Morb Mortal Wkly Rep. 2012 Nov 23;61(46):952
references.pmid: 23169317
references.citation: J Virol. 2011 Oct;85(19):9811-23
references.pmid: 21775443
references.citation: Epidemiol Infect. 2010 Apr;138(4):576-84
references.pmid: 19781114
references.citation: J Virol. 2010 Jan;84(1):227-42
references.pmid: 19828613
references.citation: Viruses. 2010 Dec;2(12):2559-86
references.pmid: 21994631
references.citation: J Virol. 2010 May;84(10):4889-97
references.pmid: 20219926
references.citation: Int J Immunogenet. 2009 Aug;36(4):227-9
references.pmid: 19473214
references.citation: J Immunol. 2007 Aug 1;179(3):1988-95
references.pmid: 17641066
references.citation: J Gen Virol. 2010 Sep;91(Pt 9):2341-50
references.pmid: 20444994
references.citation: Cell Host Microbe. 2010 Jun 25;7(6):488-99
references.pmid: 20542252
references.citation: Emerg Infect Dis. 2008 Aug;14(8):1209-15
references.pmid: 18680643
references.citation: Adv Appl Microbiol. 2011;74:35-75
references.pmid: 21459193
references.citation: Microbes Infect. 2008 Aug-Sep;10(10-11):1150-7
references.pmid: 18606242
references.citation: PLoS Pathog. 2008 Nov;4(11):e1000172
references.pmid: 19043585
references.citation: Viral Immunol. 2006 Summer;19(3):558-64
references.pmid: 16987073
references.citation: Rev Med Virol. 1998 Apr;8(2):67-86
references.pmid: 10398496
references.citation: BMC Infect Dis. 2010 May 25;10:132
references.pmid: 20500875
references.citation: Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):957-63
references.pmid: 21901638
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19294-9
references.pmid: 19047634
references.citation: Lancet Infect Dis. 2003 Oct;3(10):653-61
references.pmid: 14522264
references.citation: Thromb Res. 2010 Aug;126(2):154-8
references.pmid: 20579693
references.citation: Virology. 2008 Nov 25;381(2):178-83
references.pmid: 18834607
references.citation: J Virol. 2012 Nov;86(21):11845-55
references.pmid: 22915818
references.citation: Proc Natl Acad Sci U S A. 1978 Oct;75(10):4886-90
references.pmid: 283399
references.citation: Chest. 2011 Sep;140(3):715-722
references.pmid: 21436245
references.citation: Vaccine. 2003 Jun 1;21 Suppl 2:S43-7
references.pmid: 12763682
references.citation: Adv Virol. 2012;2012:674360
references.pmid: 22956954
references.citation: J Med Virol. 2007 Oct;79(10):1527-36
references.pmid: 17705180
references.citation: Kidney Int. 1996 Jan;49(1):217-21
references.pmid: 8770970
references.citation: Curr Top Microbiol Immunol. 2001;256:91-115
references.pmid: 11217408
references.citation: J Gen Virol. 2012 Aug;93(Pt 8):1631-1644
references.pmid: 22622328
references.citation: Virology. 2002 Mar 1;294(1):60-9
references.pmid: 11886265
references.citation: Clin Microbiol Rev. 2010 Apr;23(2):412-41
references.pmid: 20375360
references.citation: Am J Kidney Dis. 2004 May;43(5):809-16
references.pmid: 15112171
references.citation: J Med Virol. 2011 Apr;83(4):731-7
references.pmid: 21328391
references.citation: Nucleic Acids Res. 2013 Jun;41(11):5912-26
references.pmid: 23595147
references.citation: PLoS Pathog. 2013 Mar;9(3):e1003272
references.pmid: 23555267
references.citation: Arch Virol. 2010 Jun;155(6):971-5
references.pmid: 20372945
references.citation: FASEB J. 1990 Aug;4(11):2860-7
references.pmid: 2199284
references.citation: PLoS Pathog. 2011 May;7(5):e1002030
references.pmid: 21589902
references.citation: J Immunol. 2004 Dec 1;173(11):6921-7
references.pmid: 15557188
references.citation: Scand J Infect Dis. 1998;30(5):532-4
references.pmid: 10066063
references.citation: Rev Med Virol. 2013 Jan;23(1):35-49
references.pmid: 22761056
references.citation: Emerg Infect Dis. 2005 Dec;11(12):1848-53
references.pmid: 16485469
references.citation: PLoS Pathog. 2013 Feb;9(2):e1003159
references.pmid: 23408889
references.citation: J Infect Dev Ctries. 2008 Feb 01;2(1):3-23
references.pmid: 19736383
references.citation: Arch Virol. 1983;75(4):313-6
references.pmid: 6220688
references.citation: Science. 1985 Mar 1;227(4690):1041-4
references.pmid: 2858126
references.citation: BMC Immunol. 2011 Nov 16;12:65
references.pmid: 22085404
references.citation: J Virol. 2002 Aug;76(15):7587-94
references.pmid: 12097572
references.citation: J Infect Dis. 2002 Sep 15;186(6):843-6
references.pmid: 12198621
references.citation: Virology. 2008 Apr 25;374(1):138-50
references.pmid: 18234268
references.citation: Arch Virol. 2010;155(1):117-21
references.pmid: 19956987
references.citation: Virology. 2011 Sep 15;418(1):12-20
references.pmid: 21807393
references.citation: Virology. 2010 Apr 25;400(1):115-27
references.pmid: 20170933
references.citation: Virology. 2013 Mar 15;437(2):73-80
references.pmid: 23357734
references.citation: Clin Nephrol. 2000 Jun;53(6):424-31
references.pmid: 10879661
references.citation: Cell Microbiol. 2008 Oct;10(10):2012-28
references.pmid: 18547336
references.citation: Trends Microbiol. 2000 Feb;8(2):61-7
references.pmid: 10664598
references.citation: PLoS One. 2013 May 08;8(5):e64137
references.pmid: 23667701
references.citation: Hum Vaccin. 2011 Jun;7(6):685-93
references.pmid: 21508676
references.citation: N Engl J Med. 1994 Apr 7;330(14):949-55
references.pmid: 8121458
references.citation: PLoS Pathog. 2010 Sep 16;6(9):e1001101
references.pmid: 20862319
references.citation: Oecologia. 2012 Jun;169(2):431-9
references.pmid: 22218940
references.citation: Nephrol Dial Transplant. 2002 Feb;17(2):246-52
references.pmid: 11812874
references.citation: PLoS One. 2013;8(1):e55310
references.pmid: 23383148
references.citation: PLoS One. 2012;7(4):e34307
references.pmid: 22506017
references.citation: Adv Virol. 2012;2012:524024
references.pmid: 22924041
references.citation: J Exp Med. 2011 Jan 17;208(1):13-21
references.pmid: 21173105
references.citation: J Virol. 2010 Nov;84(21):11227-34
references.pmid: 20810734
references.citation: Arch Virol. 2005 Sep;150(9):1693-713
references.pmid: 15931462
references.citation: Mol Biol Evol. 2009 Jan;26(1):143-53
references.pmid: 18922760
references.citation: Clin Vaccine Immunol. 2011 Sep;18(9):1435-40
references.pmid: 21775516
references.citation: Nat Rev Immunol. 2004 Oct;4(10):762-74
references.pmid: 15459668
references.citation: Infect Genet Evol. 2008 Jul;8(4):450-8
references.pmid: 17693139
references.citation: J Gen Virol. 2004 May;85(Pt 5):1181-1189
references.pmid: 15105534
references.citation: Eur J Clin Microbiol Infect Dis. 2011 May;30(5):685-90
references.pmid: 21234633
references.citation: J Virol. 2011 Mar;85(5):2296-303
references.pmid: 21177802
references.citation: Clin Nephrol. 1996 Dec;46(6):369-78
references.pmid: 8982552
references.citation: FEBS Lett. 2013 Apr 17;587(8):1206-14
references.pmid: 23499938
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15496-501
references.pmid: 17875986
references.citation: Ann N Y Acad Sci. 2008 Dec;1149:84-9
references.pmid: 19120180
references.citation: Ecology. 2007 Aug;88(8):1911-6
references.pmid: 17824420
references.citation: Clin Nephrol. 1996 Dec;46(6):379-83
references.pmid: 8982553
references.citation: Infect Dis Clin North Am. 2010 Mar;24(1):159-73
references.pmid: 20171551
references.citation: Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7074-9
references.pmid: 9618541
references.citation: J Virol. 2007 Aug;81(16):8634-47
references.pmid: 17537852
references.citation: J Exp Med. 2002 Sep 2;196(5):579-88
references.pmid: 12208874
references.citation: Ann Med. 2012 Aug;44(5):468-75
references.pmid: 21495786
references.citation: Rev Med Virol. 2008 Jul-Aug;18(4):277-88
references.pmid: 18464294
references.citation: J Gen Virol. 2006 Aug;87(Pt 8):2127-2134
references.pmid: 16847107
references.citation: Virology. 2008 Dec 20;382(2):239-49
references.pmid: 18951604
references.citation: Vector Borne Zoonotic Dis. 2010 Aug;10(6):549-61
references.pmid: 20795916
references.citation: Immunol Rev. 2002 Aug;186:141-63
references.pmid: 12234369
references.citation: Viruses. 2011 Jul;3(7):1059-73
references.pmid: 21994770
references.citation: J Virol. 2008 May;82(9):4257-64
references.pmid: 18305044
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15502-7
references.pmid: 17878294
references.citation: Vector Borne Zoonotic Dis. 2012 May;12(5):393-9
references.pmid: 22214273
references.citation: PLoS One. 2011 Mar 21;6(3):e18070
references.pmid: 21445316
references.citation: Nephrol Dial Transplant. 2001 Jul;16(7):1368-73
references.pmid: 11427627