title: Corticotropin-releasing factor reduces tumor volume, halts further growth, and enhances the effect of chemotherapy in 4T1 mammary carcinoma in mice.
abstract: The present study examines the effect of the endogenous neuroendocrine factor, corticotropin-releasing factor (CRF), alone or in combination with 5-fluorouracil (5-FU), on 4T1 mammary tumor cells in vitro and in vivo. CRF has been detected in breast cancer tissues; however, the biological effects reported in the literature are sparse and variable. We found that exogenously administered CRF significantly reduced tumor growth without influencing angiogenesis or cell death. Furthermore, CRF reduced tumor interstitial fluid pressure (Pif) and potentiated the effect of 5-FU. These results show that CRF has antitumor effect on mammary carcinoma in mice.
authors.affiliation: Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway.
authors.forename: Linda E B
authors.initials: LE
authors.lastname: Stuhr
authors.forename: Eddie T
authors.initials: ET
authors.lastname: Wei
authors.forename: Rolf K
authors.initials: RK
authors.lastname: Reed
mesh_terms: D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D051379:Mice; D009389:Neovascularization, Pathologic
chemical_list: D003346:Corticotropin-Releasing Hormone; D005472:Fluorouracil
references.citation: Mol Cancer. 2009 Jun 02;8:30
references.pmid: 19490624
references.citation: PLoS One. 2012;7(3):e34082
references.pmid: 22479530
references.citation: Eur J Pharmacol. 1998 Jul 3;352(1):99-102
references.pmid: 9718273
references.citation: Nat Rev Cancer. 2004 Oct;4(10):806-13
references.pmid: 15510161
references.citation: J Pharm Pract. 2010 Apr;23(2):86-90
references.pmid: 21507800
references.citation: Neoplasia. 2009 Aug;11(8):812-22
references.pmid: 19649211
references.citation: Mol Cell Endocrinol. 2007 Jan 29;264(1-2):44-9
references.pmid: 17097220
references.citation: Pharmacol Rev. 1991 Dec;43(4):425-73
references.pmid: 1775506
references.citation: PLoS One. 2009 Dec 04;4(12):e8149
references.pmid: 19997591
references.citation: In Vivo. 1998 Jan-Feb;12(1):1-10
references.pmid: 9575420
references.citation: Mol Cancer. 2010 Sep 27;9:261
references.pmid: 20875132
references.citation: FASEB J. 2003 Sep;17(12):1756-8
references.pmid: 12958200
references.citation: Cancer Res. 1987 Jun 15;47(12):3039-51
references.pmid: 3555767
references.citation: Circ Res. 1994 Nov;75(5):942-8
references.pmid: 7522989
references.citation: Neuropeptides. 2010 Oct;44(5):355-61
references.pmid: 20630588
references.citation: Lab Invest. 2005 Apr;85(4):512-21
references.pmid: 15711566
references.citation: Regul Pept. 1991 Apr 25;33(2):93-104
references.pmid: 1882088
references.citation: Scand J Clin Lab Invest. 2008;68(7):602-11
references.pmid: 19378432
references.citation: Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13966-71
references.pmid: 17715296
references.citation: Cancer Metastasis Rev. 1990 Nov;9(3):253-66
references.pmid: 2292138
references.citation: Annu Rev Chem Biomol Eng. 2011;2:281-98
references.pmid: 22432620
references.citation: Cancer Res. 2002 Oct 1;62(19):5476-84
references.pmid: 12359756
references.citation: Breast Cancer Res Treat. 1990 May;15(3):175-84
references.pmid: 1973621
references.citation: Acta Neurochir Suppl. 1998;71:149-52
references.pmid: 9779170
references.citation: J Steroid Biochem Mol Biol. 2013 Sep;137:107-23
references.pmid: 23435015
references.citation: Peptides. 1998;19(7):1183-90
references.pmid: 9786168
references.citation: J Neurochem. 2003 Mar;84(5):1074-85
references.pmid: 12603831
references.citation: Annu Rev Pharmacol Toxicol. 1993;33:91-108
references.pmid: 8494356
references.citation: Cardiovasc Res. 2010 Jul 15;87(2):211-7
references.pmid: 20472565