title: Review and perspectives on pharmacological vitreolysis.
abstract: The vitreous is involved in multiple diseases when an incomplete posterior vitreous detachment (PVD) occurs. An incomplete PVD can lead to several pathological conditions. Such visually threatening conditions are traditionally of exclusive surgical interest. In contrast, pharmacological vitreolysis is the effort to reduce or eliminate the pathogenetic role of the vitreous solely by means of drug delivery. Here we aim to review and summarize the evidence available to date about this challenging new approach.
authors.affiliation: Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
authors.forename: Carlo
authors.initials: C
authors.lastname: La Spina
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Iuliano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fogliato
authors.forename: Maurizio Battaglia
authors.initials: MB
authors.lastname: Parodi
mesh_terms: D004798:Enzymes / Q000494:pharmacology*; D006801:Humans; D014822:Vitreous Body / Q000187:drug effects*; D020255:Vitreous Detachment / Q000139:chemically induced*
chemical_list: D004798:Enzymes