title: An in vivo model system for evaluation of the host response to biomaterials.
abstract: We describe an in vivo model system designed to evaluate the host response to implanted biomaterials: The partial thickness rat abdominal wall defect model. The model allows for determination of the temporal and spatial distribution of the cellular and vascular response, the remodeling of the implanted material and surrounding host soft tissue, and the function of the remodeled tissue over time.
authors.affiliation: Department of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Sicari
authors.forename: Neill
authors.initials: N
authors.lastname: Turner
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Badylak
mesh_terms: D000007:Abdominal Injuries / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D004195:Disease Models, Animal; D048091:Guided Tissue Regeneration; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D058106:Wound Closure Techniques
chemical_list: D001672:Biocompatible Materials