title: Rapid Re-challenge with Clozapine Following Pronounced Myocarditis in a Treatment-Resistance Schizophrenia Patient.
abstract: Clozapine is an atypical antipsychotic which is often effective in patients who fail to respond to other antipsychotics, but its use carries substantial risk. Myocarditis is one of the life-threatening adverse effects which occurs in about 1% of exposed patients. Re-challenge with clozapine is controversial, particularly shortly after the occurrence of the myocarditis and when there is clear and convincing evidence of cardiac damage. Aggressive use of clozapine, however, may be critical for the recovery of patients early in the course of their illness. Here we report a successful case of clozapine rechallenge following an initial aggressive dosage titration in an inpatient setting.
authors.affiliation: Department of Psychiatry, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Pichai
authors.initials: P
authors.lastname: Ittasakul
authors.forename: Anthony
authors.initials: A
authors.lastname: Archer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kezman
authors.forename: Wanlop
authors.initials: W
authors.lastname: Atsariyasing
authors.forename: Morris B
authors.initials: MB
authors.lastname: Goldman