title: Palladium-catalyzed β-arylation of silyl ketene acetals and application to the synthesis of benzo-fused δ-lactones.
abstract: Silyl ketene acetals are shown to be competent nucleophiles in Pd-catalyzed migrative C(sp(3))-H arylations. Compared to the parent ester lithium enolates, they possess decreased reactivity but enhanced chemoselectivity. This behavior was exploited through the synthesis of valuable benzo-fused δ-lactones such as 1-isochromanones and dihydrocoumarins.
authors.affiliation: Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CNRS UMR 5246, Université Claude Bernard Lyon 1 , CPE Lyon, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: Sam
authors.initials: S
authors.lastname: Aspin
authors.forename: Laura
authors.initials: L
authors.lastname: López-Suárez
authors.forename: Paolo
authors.initials: P
authors.lastname: Larini
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Goutierre
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Jazzar
authors.forename: Olivier
authors.initials: O
authors.lastname: Baudoin