title: A-FABP and its association with atherogenic risk profile and insulin resistance in young overweight and obese women.
abstract: OBJECTIVE
  We evaluated the association of A-FABP with proatherogenic risk profile and insulin resistance (IR) in young, nondiabetic, overweight/obese women.
  
  
  METHODS
  Serum A-FABP, high-sensitivity CRP, adiponectin, glucose, insulin, lipids and apolipoproteins were measured in 104 women (aged 20-45 years; BMI ≥25 kg/m(2)) and age-matched healthy controls (n = 76; BMI <25 kg/m(2)). All patients underwent blood pressure and anthropometric measurements.
  
  
  RESULTS
  A-FABP concentration was related to IR, and anthropometric and atherogenic indices. A-FABP was an independent predictor of triglyceride:high-density lipoprotein cholesterol, explaining 42% of its variation in overweight/obese women. At a cutoff level of 16 ng/ml, A-FABP discriminated between controls and overweight/obese (area under curve = 0.96) with high sensitivity and specificity. A-FABP predicted atherogenic risk, with an odds ratio of 11.2 (95% CI: 3.7-34.2), 7.1 (1.9-27.2) and 6.7 (2.6-17.2) for having elevated triglyceride:high-density lipoprotein cholesterol, apoB and CRP, respectively, and IR with an odds ratio 5.6 (1.8-17.2).
  
  
  CONCLUSIONS
  A-FABP seems to be a valuable predictor of atherogenic risk profile; if elevated it contributes to cardiovascular disease beyond its effect on IR.
authors.affiliation: Department of Laboratory Medicine, Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland.
authors.forename: Aneta
authors.initials: A
authors.lastname: Mankowska-Cyl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krintus
authors.forename: Pawel
authors.initials: P
authors.lastname: Rajewski
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sypniewska
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D016015:Logistic Models; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012306:Risk; D055815:Young Adult
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins