title: Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer's disease.
abstract: Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resonance angiography, we find cholesterol-fed rabbits also experience a decrease in the diameter of a number of cerebral blood vessels including the basilar, posterior communicating, and internal carotid arteries. Taken together, these data confirm that, despite the inability of dietary cholesterol to cross the blood-brain barrier, it does significantly enlarge ventricular volume and decrease cerebrovascular diameter in the rabbit - effects that are also seen in patients with Alzheimer's disease.
authors.affiliation: Department of Physiology and Pharmacology, and the Blanchette Rockefeller Neurosciences Institute, West Virginia University, Morgantown, WV, United States. Electronic address: bschreurs@hsc.wvu.edu.
authors.forename: B G
authors.initials: BG
authors.lastname: Schreurs
authors.forename: C A
authors.initials: CA
authors.lastname: Smith-Bell
authors.forename: S K
authors.initials: SK
authors.lastname: Lemieux
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology*; D000818:Animals; D002536:Cerebral Arteries / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D008297:Male; D011817:Rabbits
chemical_list: D002791:Cholesterol, Dietary
keywords: AD; Alzheimer’s disease; MIP; MPRAGE; MRI; TOF; animal model; apoE; apolipoprotein E; cerebrovasculature; copper; magnetic resonance imaging; magnetization prepared reduced angle gradient echo sequence; maximum intensity projection; time-of-flight; ventricle
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