title: A biased competition account of attention and memory in Alzheimer's disease.
abstract: The common view of Alzheimer's disease (AD) is that of an age-related memory disorder, i.e. declarative memory deficits are the first signs of the disease and associated with progressive brain changes in the medial temporal lobes and the default mode network. However, two findings challenge this view. First, new model-based tools of attention research have revealed that impaired selective attention accompanies memory deficits from early pre-dementia AD stages on. Second, very early distributed lesions of lateral parietal networks may cause these attention deficits by disrupting brain mechanisms underlying attentional biased competition. We suggest that memory and attention impairments might indicate disturbances of a common underlying neurocognitive mechanism. We propose a unifying account of impaired neural interactions within and across brain networks involved in attention and memory inspired by the biased competition principle. We specify this account at two levels of analysis: at the computational level, the selective competition of representations during both perception and memory is biased by AD-induced lesions; at the large-scale brain level, integration within and across intrinsic brain networks, which overlap in parietal and temporal lobes, is disrupted. This account integrates a large amount of previously unrelated findings of changed behaviour and brain networks and favours a brain mechanism-centred view on AD.
authors.affiliation: Department of Psychology, General and Experimental Psychology/Neuro-cognitive Psychology, Ludwig Maximilians Universität München, , Munich, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Finke
authors.forename: Nicholas
authors.initials: N
authors.lastname: Myers
authors.forename: Peter
authors.initials: P
authors.lastname: Bublak
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D001288:Attention / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005364:Field Dependence-Independence; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D010296:Parietal Lobe / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology*
keywords: disconnection syndrome; episodic memory; functional connectivity; mild cognitive impairment; parietal cortex; visual cognition
references.citation: Lancet. 2006 Apr 15;367(9518):1262-70
references.pmid: 16631882
references.citation: Restor Neurol Neurosci. 2006;24(4-6):287-301
references.pmid: 17119305
references.citation: Cereb Cortex. 2014 Jan;24(1):49-66
references.pmid: 23019246
references.citation: Brain. 2007 Mar;130(Pt 3):630-53
references.pmid: 17293361
references.citation: Neuroimage. 2012 Nov 15;63(3):1343-52
references.pmid: 22884936
references.citation: Neuropsychology. 1998 Jan;12(1):29-33
references.pmid: 9460732
references.citation: Neuropsychologia. 2006;44(8):1452-6
references.pmid: 16426646
references.citation: J Cogn Neurosci. 2011 Dec;23(12):4022-37
references.pmid: 21671731
references.citation: J Neurosci. 2010 Jun 23;30(25):8445-56
references.pmid: 20573892
references.citation: Neurobiol Aging. 2011 Jul;32(7):1219-30
references.pmid: 19713001
references.citation: Neuropsychology. 2006 Mar;20(2):193-205
references.pmid: 16594780
references.citation: Science. 1991 Sep 20;253(5026):1380-6
references.pmid: 1896849
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20069-74
references.pmid: 19903877
references.citation: Conscious Cogn. 2005 Jun;14(2):390-425
references.pmid: 15950889
references.citation: Psychol Rev. 2005 Apr;112(2):291-328
references.pmid: 15783288
references.citation: Hum Brain Mapp. 2014 Mar;35(3):954-63
references.pmid: 23307487
references.citation: Nat Rev Neurosci. 2002 Mar;3(3):201-15
references.pmid: 11994752
references.citation: Neurology. 1990 Mar;40(3 Pt 1):439-43
references.pmid: 2314585
references.citation: J Neurol. 2005 Jan;252(1):47-55
references.pmid: 15654553
references.citation: J Cereb Blood Flow Metab. 1985 Jun;5(2):193-200
references.pmid: 3988821
references.citation: Neuropsychologia. 2007 Apr 9;45(8):1948-60
references.pmid: 17275041
references.citation: Nat Rev Neurosci. 2008 Aug;9(8):613-25
references.pmid: 18641668
references.citation: J Neurosci. 2005 Aug 24;25(34):7709-17
references.pmid: 16120771
references.citation: Brain. 2011 Jun;134(Pt 6):1635-46
references.pmid: 21490054
references.citation: Lancet Neurol. 2007 Aug;6(8):734-46
references.pmid: 17616482
references.citation: J Neurosci. 2007 Dec 26;27(52):14415-23
references.pmid: 18160649
references.citation: Neuroimage. 2005 Jun;26(2):471-9
references.pmid: 15907304
references.citation: Arch Neurol. 1999 Mar;56(3):303-8
references.pmid: 10190820
references.citation: Neurology. 1998 Oct;51(4):1207-9
references.pmid: 9781564
references.citation: Neuron. 2009 Apr 16;62(1):42-52
references.pmid: 19376066
references.citation: Psychol Rev. 1990 Oct;97(4):523-47
references.pmid: 2247540
references.citation: Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):333-8
references.pmid: 22184233
references.citation: Science. 2008 Sep 19;321(5896):1686-9
references.pmid: 18802001
references.citation: Philos Trans R Soc Lond B Biol Sci. 1998 Aug 29;353(1373):1271-81
references.pmid: 9770221
references.citation: Front Integr Neurosci. 2012 Jun 11;6:31
references.pmid: 22701406
references.citation: Science. 2002 Jul 19;297(5580):353-6
references.pmid: 12130773
references.citation: Neurobiol Aging. 2012 Aug;33(8):1564-78
references.pmid: 21813210
references.citation: Neuropathology. 2000 Sep;20(3):239-45
references.pmid: 11132942
references.citation: Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18760-5
references.pmid: 18003904
references.citation: Neuropsychologia. 2008;46(7):1965-78
references.pmid: 18328509
references.citation: Curr Opin Neurol. 2011 Aug;24(4):364-70
references.pmid: 21725241
references.citation: Annu Rev Neurosci. 1995;18:193-222
references.pmid: 7605061
references.citation: Nature. 1997 Nov 20;390(6657):279-81
references.pmid: 9384378
references.citation: J Neurosci. 2009 Feb 11;29(6):1860-73
references.pmid: 19211893
references.citation: AJNR Am J Neuroradiol. 2013 Feb;34(2):340-5
references.pmid: 22790250
references.citation: Biol Psychiatry. 2012 May 1;71(9):798-804
references.pmid: 22079258
references.citation: Neuropsychologia. 2013 Mar;51(4):573-83
references.pmid: 23287568
references.citation: J Alzheimers Dis. 2011;25(2):347-57
references.pmid: 21422522
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
references.pmid: 19620724
references.citation: Neurobiol Aging. 2012 Jan;33(1):195.e27-42
references.pmid: 20561715
references.citation: Neuron. 2008 May 8;58(3):306-24
references.pmid: 18466742
references.citation: J Exp Psychol Gen. 1999 Dec;128(4):450-78
references.pmid: 10650583
references.citation: Lancet Neurol. 2010 Nov;9(11):1118-27
references.pmid: 20934914
references.citation: Brain Pathol. 1991 Apr;1(3):213-6
references.pmid: 1669710
references.citation: Neurobiol Learn Mem. 2009 Feb;91(2):139-54
references.pmid: 19028591
references.citation: Psychiatry Res. 2002 Feb 15;114(1):39-50
references.pmid: 11864808
references.citation: Nature. 2004 Apr 15;428(6984):751-4
references.pmid: 15085133
references.citation: Nat Neurosci. 2011 May 29;14(7):830-2
references.pmid: 21623362
references.citation: Neuropsychologia. 1995 Apr;33(4):509-23
references.pmid: 7617158
references.citation: Trends Cogn Sci. 2005 Sep;9(9):445-53
references.pmid: 16054861
references.citation: Neuron. 2012 Sep 20;75(6):1122-34
references.pmid: 22998879
references.citation: Annu Rev Psychol. 2011;62:73-101
references.pmid: 19575619
references.citation: Neuropsychologia. 2012 May;50(6):1178-89
references.pmid: 22386879
references.citation: J Clin Exp Neuropsychol. 2006 Aug;28(6):884-97
references.pmid: 16822730
references.citation: J Neurophysiol. 2006 Dec;96(6):3517-31
references.pmid: 16899645
references.citation: Neurology. 2007 May 8;68(19):1603-6
references.pmid: 17485647
references.citation: N Engl J Med. 2012 Aug 30;367(9):795-804
references.pmid: 22784036
references.citation: Hum Brain Mapp. 2012 May;33(5):1076-88
references.pmid: 21538702
references.citation: Neuron. 2012 Sep 20;75(6):944-7
references.pmid: 22998863
references.citation: Neuropsychologia. 2012 Jul;50(9):2333-40
references.pmid: 22705441
references.citation: Neurology. 2000 May 23;54(10):1954-9
references.pmid: 10822436
references.citation: Neuropsychologia. 2012 Nov;50(13):2992-3003
references.pmid: 22975148
references.citation: Neuropsychologia. 2008;46(7):1743-55
references.pmid: 18313699
references.citation: Neurology. 2006 Aug 8;67(3):446-52
references.pmid: 16894106
references.citation: J Neurosci. 2003 Feb 1;23(3):994-1005
references.pmid: 12574429
references.citation: Lancet. 2006 Jul 29;368(9533):387-403
references.pmid: 16876668
references.citation: Learn Mem. 2009 May 23;16(6):343-56
references.pmid: 19470649
references.citation: Neuron. 2010 Jul 15;67(1):156-70
references.pmid: 20624599
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Brain Cogn. 2009 Apr;69(3):504-13
references.pmid: 19101064
references.citation: Mol Psychiatry. 2011 Sep;16(9):903-7
references.pmid: 21556001
references.citation: Brain. 1991 Dec;114 ( Pt 6):2543-54
references.pmid: 1782530
references.citation: Neuropsychology. 2010 May;24(3):316-26
references.pmid: 20438209
references.citation: Biol Psychiatry. 2013 Sep 1;74(5):340-7
references.pmid: 23290495
references.citation: Lancet Neurol. 2010 Jan;9(1):119-28
references.pmid: 20083042
references.citation: Neuropsychologia. 2011 Jun;49(7):1741-50
references.pmid: 21377483
references.citation: Semin Speech Lang. 2002 May;23(2):139-50
references.pmid: 11951174
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51
references.pmid: 16788060
references.citation: Arch Neurol. 2001 Mar;58(3):397-405
references.pmid: 11255443
references.citation: Neuroimage. 2013 Nov 1;81:96-109
references.pmid: 23668966
references.citation: Neuron. 1999 Aug;23(4):747-64
references.pmid: 10482241
references.citation: Prog Neurobiol. 2001 Jan;63(1):1-27
references.pmid: 11040416
references.citation: J Vis. 2009 Dec 16;9(13):18.1-14
references.pmid: 20055551
references.citation: Annu Rev Neurosci. 2005;28:403-50
references.pmid: 16022602
references.citation: Lancet. 2005 Dec 17;366(9503):2112-7
references.pmid: 16360788
references.citation: Nat Rev Neurosci. 2007 Sep;8(9):700-11
references.pmid: 17704812
references.citation: J Alzheimers Dis. 2011;25(2):309-21
references.pmid: 21422523
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references.pmid: 18400922
references.citation: Psychol Rev. 2002 Apr;109(2):376-400
references.pmid: 11990323
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references.pmid: 15070770
references.citation: Neuropsychology. 2008 Mar;22(2):177-87
references.pmid: 18331160
references.citation: Neuron. 2005 Dec 22;48(6):913-22
references.pmid: 16364896
references.citation: Brain. 1999 Mar;122 ( Pt 3):383-404
references.pmid: 10094249
references.citation: Brain. 2006 Nov;129(Pt 11):2856-66
references.pmid: 16854944
references.citation: Neuron. 2009 Jul 30;63(2):178-88
references.pmid: 19640477
references.citation: Brain Cogn. 2009 Jun;70(1):171-9
references.pmid: 19250730