title: Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP).
abstract: BACKGROUND
  Few genetic risk factors have been uncovered that contribute specifically to the racial disparity in prostate cancer (CaP) observed in African Americans (AA). With the advent of ancestry informative marker (AIM) single nucleotide polymorphism (SNP) panels and powerful genetic strategies such as mapping by admixture linkage disequilibrium (MALD) it is possible to discover genes that underlie ethnic variation in disease risk.
  
  
  METHODS
  One thousand one hundred thirty AA CaP cases enrolled in the North Carolina-Louisiana Prostate Cancer Project (PCaP) were genotyped using a 1,509 AIM SNP panel. MALD was performed using ADMIXMAP to test for linkage between CaP risk and ancestry estimates at each AIM SNP.
  
  
  RESULTS
  The largest increase of African ancestry was observed at marker rs12543473 (P = 0.0011), located on chromosome 8q24.21, and the greatest excess of European ancestry was observed at marker rs10768140 (P = 0.0004) at chromosome 11p13.
  
  
  CONCLUSIONS
  The study confirmed the 8q24 risk loci and identified a novel genomic region on 11p13 that is associated with CaP risk. These findings should be replicated in larger AA populations and combined with fine mapping data to further refine the novel 11p13 CaP risk loci.
authors.affiliation: Department of Epidemiology, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Jeannette T
authors.initials: JT
authors.lastname: Bensen
authors.forename: Zongli
authors.initials: Z
authors.lastname: Xu
authors.forename: Paul M
authors.initials: PM
authors.lastname: McKeigue
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Smith
authors.forename: Elizabeth T H
authors.initials: ET
authors.lastname: Fontham
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
authors.forename: Jack A
authors.initials: JA
authors.lastname: Taylor
mesh_terms: D000328:Adult; D001741:Black or African American / Q000208:ethnology* / Q000235:genetics*; D000368:Aged; D002874:Chromosome Mapping / Q000379:methods*; D006801:Humans; D015810:Linkage Disequilibrium / Q000502:physiology; D008145:Louisiana / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009657:North Carolina / Q000208:ethnology; D011159:Population Surveillance / Q000379:methods; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000235:genetics*
keywords: African American; MALD; SNP; ancestry informative markers; mapping by admixture linkage disequilibrium; prostate cancer
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