title: Male infertility: assessment of juvenile testicular dysfunction and risk for malignancy in cryptorchid boys based on resin section evaluation.
abstract: Infertility is sometimes more a man's problem than a woman's, failure of one or both of the testes to descend (cryptorchidism) being the most frequent genital malformation in boys. Untreated, the undescended testis impairs germ cell development and significantly reduces adult fertility. A-dark spermatogonia are the stem cells for all future spermatozoa, and their depletion can be reliably estimated in resin semithin sections. Additionally, there is an increased risk of testicular preneoplasia in the form of carcinoma in situ (CIS) cells. The authors report how the pathologic biopsy examination of juvenile cryptorchid testes can assess infertility and malignancy risk.
authors.affiliation: Department of Pathology, Central EM Laboratory .
authors.forename: Josef A
authors.initials: JA
authors.lastname: Schroeder
authors.forename: Heiko I
authors.initials: HI
authors.lastname: Siegmund
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Roesch
authors.forename: Faruk
authors.initials: F
authors.lastname: Hadziselimovic
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Hofstaedter
mesh_terms: D000367:Age Factors; D001706:Biopsy; D002278:Carcinoma in Situ / Q000209:etiology* / Q000648:ultrastructure; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000150:complications* / Q000473:pathology; D004853:Epoxy Resins; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009373:Neoplasms, Germ Cell and Embryonal / Q000209:etiology* / Q000648:ultrastructure; D012307:Risk Factors; D013093:Spermatogonia / Q000648:ultrastructure*; D013736:Testicular Neoplasms / Q000209:etiology* / Q000648:ultrastructure; D013737:Testis / Q000648:ultrastructure*
chemical_list: D004853:Epoxy Resins; C004875:EPON