title: Prognostic value of nuclear translocation of aryl hydrocarbon receptor for non-small cell lung cancer.
abstract: BACKGROUND
  The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor which translocates from the cytoplasm to the nucleus after activation. AhR overexpression is positively associated with epidermal growth factor (EGFR) expression in non-small cell lung cancer (NSCLC). The association between AhR expression and types of EGFR mutation, and the prognostic value of AhR expression in NSCLC remain unclear.
  
  
  METHODS
  The AhR expression and detection of L858R and E746-750A deletion of EGFR in NSCLC was assessed using immunohistochemistry.
  
  
  RESULTS
  Nuclear translocation of AhR was more common in females, non-smokers, adenocarcinoma (AD) and NSCLC patients with EGFR E746-750A deletion. The overall median survival time (MST) was 20.4 months for patients with NSCLC, 21.8 months for these with AD and 15.4 months for these with squamous cell carcinoma (SQ). The MST was significantly reduced in patients with poor performance status, SQ or advanced cancer stage. AhR nuclear translocation was associated with cancer death in SQ (hazard ratio=3.714, p<0.001) but not in AD (hazard ratio=0.837, p=0.407).
  
  
  CONCLUSIONS
  Nuclear translocation of AhR was associated with EGFR mutation, and conferred a poor prognosis for patients with lung SQ.
authors.affiliation: Department of Pathology, School of Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung, Taiwan 40402, R.O.C. changhan@mail.cmu.edu.tw.
authors.forename: Jang-Ming
authors.initials: JM
authors.lastname: Su
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
authors.forename: Han
authors.initials: H
authors.lastname: Chang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009154:Mutation; D011379:Prognosis; D021381:Protein Transport; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D018336:Receptors, Aryl Hydrocarbon; D066246:ErbB Receptors
keywords: Aryl hydrocarbon receptor; epidermal growth factor receptor; non-small cell lung cancer; prognosis