title: Neurosurgical interventions for patients with nasopharyngeal carcinoma: a single institution experience.
abstract: BACKGROUND
  Nasopharyngeal carcinoma (NPC) is a frequent head and neck cancer in southern China and Southeast Asia. The majority of NPC patients are managed by radiation oncologists, medical oncologists and head and neck surgeons. Actually, neurosurgical interventions are warranted under specific circumstances. In this article, we described our experience as neurosurgeons in the management of NPC patients.
  
  
  METHODS
  Medical records of NPC patients who received neurosurgical procedure at Sun Yat-sen University Cancer Center were reviewed.
  
  
  RESULTS
  Twenty-seven patients were identified. Among 27 cases, neurosurgical procedures were performed in 18 (66.7%) with radiation-induced temporal necrosis, 2 (7.4%) with radiation-induced sarcoma, 4 (14.8%) with synchronous NPC with primary brain tumors, 2 (7.4%) with recurrent NPC involving skull base, and 1 (3.7%) with metachronous skull eosinophilic granuloma, respectively. The diagnosis is challenging in specific cases and initial misdiagnoses were found in 6 (22.2%) patients.
  
  
  CONCLUSIONS
  For NPC patients with intracranial or skull lesions, the initial diagnosis can be occasionally difficult because of the presence or a history of NPC and related treatment. Unawareness of these entities can result in misdiagnosis and subsequent improper treatment. Neurosurgical interventions are necessary for the diagnosis and treatment for these patients.
authors.affiliation: Department of Neurosurgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Ghuangzhou 510060, China. chenzp57@mail.sysu.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Sai
authors.forename: Yong-gao
authors.initials: YG
authors.lastname: Mou
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Yan-chun
authors.initials: YC
authors.lastname: Lv
authors.forename: Shao-yan
authors.initials: SY
authors.lastname: Xi
authors.forename: Su
authors.initials: S
authors.lastname: Guan
authors.forename: Xiang-heng
authors.initials: XH
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Ke
authors.forename: Jian-gui
authors.initials: JG
authors.lastname: Guo
authors.forename: Yin-sheng
authors.initials: YS
authors.lastname: Chen
authors.forename: Zhong-ping
authors.initials: ZP
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D019635:Neurosurgical Procedures; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D012509:Sarcoma / Q000209:etiology / Q000473:pathology / Q000601:surgery*
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