title: Comprehensive assessment and network analysis of the emerging genetic susceptibility landscape of prostate cancer.
abstract: BACKGROUND
  Recent advances in high-throughput genotyping have made possible identification of genetic variants associated with increased risk of developing prostate cancer using genome-wide associations studies (GWAS). However, the broader context in which the identified genetic variants operate is poorly understood. Here we present a comprehensive assessment, network, and pathway analysis of the emerging genetic susceptibility landscape of prostate cancer.
  
  
  METHODS
  We created a comprehensive catalog of genetic variants and associated genes by mining published reports and accompanying websites hosting supplementary data on GWAS. We then performed network and pathway analysis using single nucleotide polymorphism (SNP)-containing genes to identify gene regulatory networks and pathways enriched for genetic variants.
  
  
  RESULTS
  We identified multiple gene networks and pathways enriched for genetic variants including IGF-1, androgen biosynthesis and androgen signaling pathways, and the molecular mechanisms of cancer. The results provide putative functional bridges between GWAS findings and gene regulatory networks and biological pathways.
authors.affiliation: Cancer Institute, University of Mississippi Medical Center, Jackson, MS. ; Department of Medicine, University of Mississippi Medical Center, Jackson, MS. ; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS.
authors.forename: Chindo
authors.initials: C
authors.lastname: Hicks
authors.forename: Lucio
authors.initials: L
authors.lastname: Miele
authors.forename: Tejaswi
authors.initials: T
authors.lastname: Koganti
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vijayakumar
keywords: prostate cancer GWAS network pathway analysis
references.citation: Trends Endocrinol Metab. 2010 May;21(5):315-24
references.pmid: 20138542
references.citation: Nat Rev Genet. 2005 Nov;6(11):847-59
references.pmid: 16304600
references.citation: Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
references.pmid: 19622511
references.citation: J Natl Cancer Inst. 2004 Mar 17;96(6):434-42
references.pmid: 15026468
references.citation: Endocr Rev. 2004 Apr;25(2):276-308
references.pmid: 15082523
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7
references.pmid: 19474294
references.citation: Nat Genet. 2000 May;25(1):25-9
references.pmid: 10802651
references.citation: Bioessays. 2007 Dec;29(12):1227-38
references.pmid: 18008377
references.citation: Nature. 2011 Feb 10;470(7333):214-20
references.pmid: 21307934
references.citation: Int J Epidemiol. 2008 Feb;37(1):120-32
references.pmid: 17898028
references.citation: Am J Hum Genet. 2004 Sep;75(3):353-62
references.pmid: 15272419
references.citation: Eur J Hum Genet. 2010 Sep;18(9):1045-53
references.pmid: 20442747
references.citation: Cancer Epidemiol. 2012 Aug;36(4):347-53
references.pmid: 22542949
references.citation: Curr Opin Pharmacol. 2008 Aug;8(4):440-8
references.pmid: 18674639
references.citation: Cancer Inform. 2011;10:185-204
references.pmid: 21869864
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000100
references.pmid: 19621070
references.citation: N Engl J Med. 2010 Jul 8;363(2):166-76
references.pmid: 20647212
references.citation: PLoS Med. 2009 Mar 3;6(3):e28
references.pmid: 19260758
references.citation: Hum Hered. 2007;64(4):203-13
references.pmid: 17551261
references.citation: Am J Epidemiol. 2009 Aug 1;170(3):269-79
references.pmid: 19498075
references.citation: Hum Mol Genet. 2013 Jan 15;22(2):408-15
references.pmid: 23065704
references.citation: Am J Hum Genet. 2003 Oct;73(4):711-9
references.pmid: 13680525
references.citation: Endocrinology. 2007 Jul;148(7):3089-101
references.pmid: 17412813
references.citation: Crit Rev Clin Lab Sci. 1998 Aug;35(4):275-368
references.pmid: 9759557
references.citation: Nat Rev Genet. 2006 Oct;7(10):781-91
references.pmid: 16983374
references.citation: Nature. 2012 Jul 12;487(7406):239-43
references.pmid: 22722839
references.citation: Trends Mol Med. 2005 Feb;11(2):52-5
references.pmid: 15694866
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2396-403
references.pmid: 21960693
references.citation: Lancet Oncol. 2011 May;12(5):477-88
references.pmid: 21514219
references.citation: J Clin Oncol. 2005 Nov 10;23(32):8253-61
references.pmid: 16278481
references.citation: Nat Genet. 2005 Nov;37(11):1243-6
references.pmid: 16228001
references.citation: Cancer Inform. 2013;12:1-20
references.pmid: 23423317
references.citation: Nature. 2009 Sep 10;461(7261):218-23
references.pmid: 19741703
references.citation: Nature. 2007 Jun 7;447(7145):655-60
references.pmid: 17554299