title: Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis.
abstract: An actinomycin-D producing strain was isolated from soil and characterized as Streptomyces sindenensis. The culture was subjected to UV irradiation and a mutant with 400% higher actinomycin-D production was isolated (400 mg/l(-1) as compared to 80 mg/l(-1) produced by the parent). Production medium was optimized and antibiotic yield with the mutant was enhanced to 850 mg/l(-1) which is 963% higher as compared with the parent.
authors.affiliation: Fermentation Technology Division, Central Drug Research Institute, Chattar Manzil , Lucknow-226001 , India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Praveen
authors.forename: C K M
authors.initials: CK
authors.lastname: Tripathi
authors.forename: Vinod
authors.initials: V
authors.lastname: Bihari
authors.forename: S C
authors.initials: SC
authors.lastname: Srivastava
keywords: Actinomycin-D; Streptomyces; antibiotics; mutation
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