title: Papillomavirus associated diseases of the horse.
abstract: The Papillomaviridae family comprises a large number of viruses that can infect a broad range of hosts including mammals, birds and reptiles giving rise to benign lesions of the skin or mucosal membranes. They are characterized by great genetic diversity yet adhere to common biological principles. In this review, we first describe the structure and function of the viral proteins encoded by papillomaviruses (PVs), with a particular emphasis on bovine papillomaviruses (BPV). We then discuss the role of BPV types 1 and 2 in the pathogenesis of equine sarcoids and present recent evidence implicating a novel equine papillomavirus (EcPV-2) in the pathogenesis of equine genital cancers.
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, College of Medical, Veterinary and Life Sciences, Garscube Estate, Bearsden Road, Glasgow G61 1QH, Scotland, UK. Electronic address: lubna.nasir@gla.ac.uk.
authors.forename: Lubna
authors.initials: L
authors.lastname: Nasir
authors.forename: Sabine
authors.initials: S
authors.lastname: Brandt
mesh_terms: D000818:Animals; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D027383:Papillomaviridae / Q000235:genetics / Q000502:physiology*; D030361:Papillomavirus Infections / Q000662:veterinary* / Q000821:virology; D012867:Skin / Q000821:virology; D012878:Skin Neoplasms / Q000662:veterinary; D014685:Venereal Tumors, Veterinary / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins
keywords: Bovine papillomavirus; Equine genital cancers; Equine sarcoid; Papillomavirus