title: Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes.
abstract: Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G-quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres.
authors.affiliation: Department of Chemistry & Biochemistry, Kent State University, Williams Hall, Kent, OH 44242 (USA).
authors.forename: Philip M
authors.initials: PM
authors.lastname: Yangyuoru
authors.forename: Amy Y Q
authors.initials: AY
authors.lastname: Zhang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Shi
authors.forename: Deepak
authors.initials: D
authors.lastname: Koirala
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
authors.forename: Hanbin
authors.initials: H
authors.lastname: Mao
mesh_terms: D001483:Base Sequence; D054856:G-Quadruplexes; D006801:Humans; D055595:Mechanical Phenomena; D008958:Models, Molecular; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D016615:Telomere / Q000235:genetics*
chemical_list: D012313:RNA
keywords: G-quadruplexes; RNA structures; TERRA; laser tweezers; mechanical stability; mechanochemistry; single molecules