title: Effect of omega-3 on brain natriuretic peptide and echocardiographic findings in heart failure: Double-blind placebo-controlled randomized trial.
abstract: BACKGROUND
  Possible beneficial effects of dietary omega-3 supplementation on patients with congestive heart failure (CHF) were investigated.
  
  
  RESULTS
  100 patients with CHF who had a tri-chamber pacemaker and automated defibrillator were initially recruited, and 70 agreed to participate.38 patients received 2 g/day of omega-3 and 32 received placebo capsules. BNP level, 6-min walk test and echocardiographic parameters were recorded at baseline and after 6 months of treatment. BNP levels decreased significantly after 6 months in the omega-3 group, from 1766.2 ± 1978.1 pg/mL to 1159.4 ± 1430.9 pg/dL (P < 0.005). Tei index and late diastolic velocity index were significantly improved in treated group. Mortality and hospitalization rates did not differ.
  
  
  CONCLUSIONS
  The beneficial effects of omega-3 supplementation in patients with CHF were not as clear as hypothesized; however, omega-3 fatty acids can result in small changes in plasma BNP levels and modest improvements in echocardiographically assessed diastolic function (Clinical trial.gov registration: NCT01227837).
authors.affiliation: Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran ; Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: J
authors.initials: J
authors.lastname: Kojuri
authors.forename: M A
authors.initials: MA
authors.lastname: Ostovan
authors.forename: G R
authors.initials: GR
authors.lastname: Rezaian
authors.forename: P
authors.initials: P
authors.lastname: Archin Dialameh
authors.forename: N
authors.initials: N
authors.lastname: Zamiri
authors.forename: M B
authors.initials: MB
authors.lastname: Sharifkazemi
authors.forename: M
authors.initials: M
authors.lastname: Jannati
keywords: Brain natriuretic peptide; Congestive; Heart failure; Omega-3
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