title: Association of single-nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open-angle glaucoma: a meta-analysis.
abstract: BACKGROUND
  To clarify the effects of a single-nucleotide polymorphism, rs4236601[A] near caveolin 1 and 2, on primary open-angle glaucoma (POAG) risk.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  A total of 5774 patients and 40 598 controls from previously reported case-control studies were included.
  
  
  METHODS
  A comprehensive literature search was performed for studies published up to April 2013. Summary odds ratios (ORs) and 95% confidence intervals (CI) were calculated, employing random- or fixed-effects models according to between-study heterogeneity. Publication bias of the literature articles was evaluated using funnel plots and Egger's test.
  
  
  METHODS
  OR for the effects of rs4236601[A] on POAG risk.
  
  
  RESULTS
  Five eligible studies were included in this meta-analysis. Overall, the association between rs4236601[A] and risk for POAG was statistically significant (OR = 1.23, 95% CI 1.12-1.34; P < 0.001). Stratified analyses showed that the association between rs4236601[A] and POAG risk was statistically significant in Caucasians (OR = 1.25, 95% CI 1.18-1.33; P < 0.001) and Asians (OR = 3.33, 95% CI 1.56-7.08; P = 0.003) but not in Africans. Increased risks were found in age- and sex-matched studies (OR = 1.26, 95% CI 1.14-1.40; P < 0.001), but no statistically significant risk was found in unmatched studies.
  
  
  CONCLUSIONS
  This meta-analysis suggests that rs4236601[A] is associated with increased risk for POAG in Caucasian and Asian populations. However, well-designed gene-environment interaction studies and studies including more ethnic groups are required in further investigations.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Minwen
authors.initials: M
authors.lastname: Zhou
authors.forename: Xiulan
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D051243:Caveolin 2 / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C495540:CAV1 protein, human; C495544:CAV2 protein, human; D051242:Caveolin 1; D051243:Caveolin 2
keywords: caveolin; primary open-angle glaucoma; rs4236601