title: Effects of creatine supplementation on biomarkers of hepatic and renal function in young trained rats.
abstract: Creatine supplementation has been widely used by athletes and young physical exercise practioneers in order of increasing muscle mass and enhancing athletic performance, but their use/overuse may represent a health risk on hepatic and renal impaired function. In this study, we evaluated the effects of 40 days of oral creatine supplementation on hepatic and renal function biomarkers in a young animal model. Wistar rats (5 weeks old) were divided in five groups (n = 7): control (CONTR), oral creatine supplementation (CREAT), moderate exercise training (EXERC), moderate exercise training plus oral creatine supplementation (EXERC + CREAT) and pathological group (positive control for liver and kidney injury) by the administration of rifampicin (RIFAMPICIN). Exercise groups were submitted to 60 min/day of swimming exercise session with a 4% of body weight workload for six weeks. The EXERC + CREAT showed the higher body weight at the end of the training protocol. The CREAT and EXERC + CREAT group showed an increase in hepatic (Aspartate transaminase and gamma-glutamyl transpeptidase) and renal (urea and creatinine) biomarkers levels (p < 0.05). Our study showed that the oral creatine supplementation promoted hepatic and renal function challenge in young rats submitted to moderate exercise training.
authors.affiliation: School of Medicine in Ribeirão Preto, University of São Paulo, Ribeirão Preto , SP , Brazil .
authors.forename: William Marciel
authors.initials: WM
authors.lastname: Souza
authors.forename: Thiago Gomes
authors.initials: TG
authors.lastname: Heck
authors.forename: Evanio Castor
authors.initials: EC
authors.lastname: Wronski
authors.forename: Anderson Zampier
authors.initials: AZ
authors.lastname: Ulbrich
authors.forename: Everton
authors.initials: E
authors.lastname: Boff
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism; D045930:Anabolic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003401:Creatine / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D045930:Anabolic Agents; D015415:Biomarkers; D003401:Creatine