title: Systems approaches to studying the immune response in tuberculosis.
abstract: Tuberculosis (TB) remains a disease of considerable mortality and morbidity. Studies employing microarrays to derive transcriptional profiles of the host response during TB, which combined with data from experimental systems have highlighted a potentially detrimental role for type I interferons during infection, with important implications for vaccine and therapeutic development. In addition, these studies have provided candidate biomarkers which may advance diagnosis and treatment monitoring. These studies thus exemplify the promise of a systems biology approach to study complex infectious disease such as TB.
authors.affiliation: Division of Immunoregulation, MRC National Institute for Medical Research, London NW7 1AA, UK; Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, St. Mary's Hospital, London W2 1NY, UK.
authors.forename: Matthew Paul Reddoch
authors.initials: MP
authors.lastname: Berry
authors.forename: Simon
authors.initials: S
authors.lastname: Blankley
authors.forename: Christine Marian
authors.initials: CM
authors.lastname: Graham
authors.forename: Chloe I
authors.initials: CI
authors.lastname: Bloom
authors.forename: Anne
authors.initials: A
authors.lastname: O'Garra
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007370:Interferon Type I / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D049490:Systems Biology / Q000379:methods*; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
chemical_list: D007370:Interferon Type I