title: Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.
abstract: A systematic review was conducted to identify evidence-based interventions (EBIs) for increasing HIV medication adherence behavior or decreasing HIV viral load among persons living with HIV (PLWH). We conducted automated searches of electronic databases (i.e., MEDLINE, EMBASE, PsycINFO, CINAHL) and manual searches of journals, reference lists, and listservs. Interventions were eligible for the review if they were U.S.-based, published between 1996 and 2011, intended to improve HIV medication adherence behaviors of PLWH, evaluated the intervention using a comparison group, and reported outcome data on adherence behaviors or HIV viral load. Each intervention was evaluated on the quality of study design, implementation, analysis, and strength of findings. Of the 65 eligible interventions, 10 are EBIs. The remaining 55 interventions failed to meet the efficacy criteria primarily due to null findings, small sample sizes, or low retention rates. Research gaps and future directions for development of adherence EBIs are discussed.
authors.affiliation: Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop E-37, Atlanta, GA, 30333, USA.
authors.forename: Mahnaz R
authors.initials: MR
authors.lastname: Charania
authors.forename: Khiya J
authors.initials: KJ
authors.lastname: Marshall
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Lyles
authors.forename: Nicole
authors.initials: N
authors.lastname: Crepaz
authors.forename: Linda S
authors.initials: LS
authors.lastname: Kay
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Koenig
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Weidle
authors.forename: David W
authors.initials: DW
authors.lastname: Purcell
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage; D000328:Adult; D017280:Condoms; D037001:Directive Counseling / Q000379:methods; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006291:Health Policy; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D040242:Risk Reduction Behavior; D012309:Risk-Taking; D012725:Sexual Behavior / Q000523:psychology / Q000706:statistics & numerical data*; D014481:United States; D016903:Drug Monitoring
chemical_list: D016915:AIDS Vaccines
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