title: Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters.
abstract: Over the past 15years there have been extensive efforts to understand and reduce the high attrition rates of drug candidates with an increased focus on physicochemical properties. The fruits of this labor have been the generation of numerous efficiency indices, metric-based rules and visualization tools to help guide medicinal chemists in the design of new compounds with more favorable properties. This deluge of information may have had the unintended consequence of further obfuscating molecular optimizations by the inability of these scoring functions, rules and guides to reach a consensus on when a particular transformation is identified as beneficial. In this manuscript, several composite parameters, or efficiency indices, are examined utilizing theoretical and experimental matched molecular pair analyses in order to understand the basis for how each will perform under varying scenarios of molecular optimizations. In contrast to empirically derived composite parameters based on heavy atom count, lipophilic efficiency (LipE) sets consistent expectations regardless of molecular weight or relative potency and can be used to generate consistent expectations for any matched molecular pair.
authors.affiliation: Novartis Institutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: michael.shultz@novartis.com.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Shultz
mesh_terms: D015195:Drug Design; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D008958:Models, Molecular; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D008024:Ligands; D008055:Lipids; D004364:Pharmaceutical Preparations
keywords: Composite parameters; Efficiency metrics; Ligand efficiency; Lipophilic efficiency