title: Lipofuscin: formation, effects and role of macroautophagy.
abstract: Oxidative stress plays a crucial role in the development of the aging process and age dependent diseases. Both are closely connected to disturbances of proteostasis by protein oxidation and an impairment of the proteasomal system. The final consequence is the accumulation of highly cross-linked undegradable aggregates such as lipofuscin. These aggregates of damaged proteins are detrimental to normal cell functions. Here we provide an overview about effect of these aggregates on the proteasomal system, followed by transcription factor activation and loss of cell viability. Furthermore, findings on the mechanism of radical genesis, proteasomal inhibition and the required components of lipofuscin formation were resumed.
authors.affiliation: Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Höhn
authors.forename: Tilman
authors.initials: T
authors.lastname: Grune
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D008062:Lipofuscin / Q000096:biosynthesis* / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D008062:Lipofuscin; D014157:Transcription Factors; D046988:Proteasome Endopeptidase Complex
keywords: Aging; Autophagy; Lipofuscin; Oxidative stress; Proteasome
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