title: Enantioseparation of flinderoles and borreverines by HPLC on Chirobiotic V and V2 stationary phases and by CE using cyclodextrin selectors.
abstract: Racemic mixtures of the promising anti-malarial bisindole alkoids, flinderole A-C, desmethyl flinderole C, borreverine and isoborreverine, are baseline-separated for the first time by HPLC using vancomycin-based stationary phases and partially separated by capillary electrophoresis (CE) using cyclodextrin selectors. The HPLC results compare the performance of Chirobiotic V and V2 in the polar organic and reversed phase modes and their complementary selectivity is discussed. The performance of the cyclodextrin selectors in CE, while less effective, are discussed in terms of their selectivity in normal and reversed polarity modes.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, USA.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Smuts
authors.forename: Yun-Cheol
authors.initials: YC
authors.lastname: Na
authors.forename: Ravikrishna
authors.initials: R
authors.lastname: Vallakati
authors.forename: Adam
authors.initials: A
authors.lastname: Přibylka
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong
mesh_terms: D000327:Adsorption; D000470:Alkaloids / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D026121:Indole Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D003505:Cyclodextrins; D026121:Indole Alkaloids; D007211:Indoles; D010936:Plant Extracts; C027496:borreverine