title: Common FABP4 genetic variants and plasma levels of fatty acid binding protein 4 in older adults.
abstract: We examined common variants in the fatty acid binding protein 4 gene (FABP4) and plasma levels of FABP4 in adults aged 65 and older from the Cardiovascular Health Study. We genotyped rs16909187, rs1054135, rs16909192, rs10808846, rs7018409, rs2290201, and rs6992708 and measured circulating FABP4 levels among 3190 European Americans and 660 African Americans. Among European Americans, the minor alleles of six single nucleotide polymorphisms (SNP) were associated with lower FABP4 levels (all p ≤ 0.01). Among African Americans, the SNP with the lowest minor allele frequency was associated with lower FABP4 levels (p = 0.015). The C-A haplotype of rs16909192 and rs2290201 was associated with lower FABP4 levels in both European Americans (frequency = 16 %; p = 0.001) and African Americans (frequency = 8 %; p = 0.04). The haplotype combined a SNP in the first intron with one in the 3'untranslated region. However, the alleles associated with lower FABP4 levels were associated with higher fasting glucose in meta-analyses from the MAGIC consortium. These results demonstrate associations of common SNP and haplotypes in the FABP4 gene with lower plasma FABP4 but higher fasting glucose levels.
authors.affiliation: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Mukamal
authors.forename: Jemma B
authors.initials: JB
authors.lastname: Wilk
authors.forename: Mary L
authors.initials: ML
authors.lastname: Biggs
authors.forename: Majken K
authors.initials: MK
authors.lastname: Jensen
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Ix
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Kizer
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Zieman
authors.forename: Dariush
authors.initials: D
authors.lastname: Mozaffarian
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D015992:Body Mass Index; D015331:Cohort Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D007328:Insulin / Q000097:blood; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D001786:Blood Glucose; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin
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