title: Comparison of cytokine immune responses to Brucella abortus and Yersinia enterocolitica serotype O:9 infections in BALB/c mice.
abstract: Brucella abortus and Yersinia enterocolitica serotype O:9 serologically cross-react in the immune response with the host; therefore, our aim was to compare the immune responses to these two pathogens. We selected typical B. abortus and Y. enterocolitica O:9 strains to study the cytokine immune response and the histopathological changes in livers and spleens of BALB/c mice. The data showed the cytokine responses to the two strains of pathogens were different, where the average levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), gamma interferon (IFN-γ), interleukin-12 (IL-12), and tumor necrosis factor alpha (TNF-α) were higher with B. abortus infections than with Y. enterocolitica O:9 infections, especially for IFN-γ, while the IL-10 level was lower and the levels of IL-1β, IL-4, IL-5, and IL-6 were similar. The histopathological effects in the livers and spleens of the BALB/c mice with B. abortus and Y. enterocolitica O:9 infections were similar; however, the pathological changes in the liver were greater with B. abortus infections, while damage in the spleen was greater with Y. enterocolitica O:9 infections. These observations show that different cytokine responses and histopathological changes occur with B. abortus and Y. enterocolitica O:9 infections.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Gu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Qiu
authors.forename: Buyun
authors.initials: B
authors.lastname: Cui
authors.forename: Shiwen
authors.initials: S
authors.lastname: Zhao
authors.forename: Han
authors.initials: H
authors.lastname: Zheng
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Xiao
authors.forename: Junrong
authors.initials: J
authors.lastname: Liang
authors.forename: Ran
authors.initials: R
authors.lastname: Duan
authors.forename: Huaiqi
authors.initials: H
authors.lastname: Jing
mesh_terms: D000818:Animals; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000276:immunology*
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D015848:Interleukin-5; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
references.citation: J Clin Microbiol. 2011 Apr;49(4):1251-9
references.pmid: 21325549
references.citation: Immunology. 1993 Nov;80(3):458-64
references.pmid: 8288319
references.citation: Infect Immun. 1995 Apr;63(4):1387-90
references.pmid: 7890399
references.citation: Mol Immunol. 2013 Oct;55(3-4):365-71
references.pmid: 23582306
references.citation: Infect Immun. 1992 Oct;60(10):4407-9
references.pmid: 1398950
references.citation: Infect Immun. 1996 Nov;64(11):4534-41
references.pmid: 8890203
references.citation: PLoS One. 2012;7(5):e37309
references.pmid: 22615971
references.citation: Microbiol Immunol. 2012 Sep;56(9):583-94
references.pmid: 22671974
references.citation: Front Cell Infect Microbiol. 2012 Apr 27;2:55
references.pmid: 22919646
references.citation: PLoS One. 2011 Jan 14;6(1):e16203
references.pmid: 21264260
references.citation: BMC Microbiol. 2005 May 04;5:22
references.pmid: 15869716
references.citation: Immunology. 2001 Aug;103(4):511-8
references.pmid: 11529943
references.citation: Infect Immun. 1992 Apr;60(4):1465-72
references.pmid: 1548070
references.citation: Med Microbiol Immunol. 1992;181(6):333-8
references.pmid: 1287419
references.citation: J Immunol. 2002 Mar 1;168(5):2433-40
references.pmid: 11859135
references.citation: Int J Food Microbiol. 2008 Jul 31;125(3):259-66
references.pmid: 18541322
references.citation: Biomed Environ Sci. 2012 Jun;25(3):282-90
references.pmid: 22840578
references.citation: Infect Immun. 2011 Sep;79(9):3619-32
references.pmid: 21730088
references.citation: Clin Exp Rheumatol. 1987;5 Suppl 1:S25-7
references.pmid: 3308236
references.citation: Microbiol Mol Biol Rev. 1998 Dec;62(4):1315-52
references.pmid: 9841674
references.citation: Jpn J Infect Dis. 2010 Jan;63(1):49-51
references.pmid: 20093762
references.citation: Infect Immun. 1993 Jan;61(1):124-34
references.pmid: 8418034
references.citation: Clin Diagn Lab Immunol. 1996 Jul;3(4):472-6
references.pmid: 8807216
references.citation: Int J Syst Evol Microbiol. 2006 May;56(Pt 5):1167-1168
references.pmid: 16736566
references.citation: Infect Immun. 1996 Apr;64(4):1357-68
references.pmid: 8606101
references.citation: Clin Microbiol Rev. 2003 Jan;16(1):65-78
references.pmid: 12525425
references.citation: Clin Dev Immunol. 2012;2012:589494
references.pmid: 22194770
references.citation: J Clin Invest. 1995 Jan;95(1):55-65
references.pmid: 7814646
references.citation: Infect Immun. 1993 Nov;61(11):4899-901
references.pmid: 8406893
references.citation: Ann Rheum Dis. 1987 Jul;46(7):510-4
references.pmid: 3662638
references.citation: PLoS One. 2012;7(11):e50214
references.pmid: 23189190
references.citation: Clin Diagn Lab Immunol. 2000 Jan;7(1):114-8
references.pmid: 10618289