title: Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism.
abstract: Chlamydia trachomatis infections are a global health problem. This obligate intracellular bacterial pathogen comprises lymphogranuloma venereum (L1-L3), ocular (A-C) and genital (D-K) serovars. Although genetically similar, each serovar group differs in disease severity and tissue tropism through mechanisms that are not well understood. It is clear that host genetic differences also play a role in chlamydial disease outcome and key host polymorphisms are beginning to emerge from both human and experimental animal studies. In this review, we will highlight pathogen and host genes that link genetic diversity, disease severity and tissue tropism. We will also use this information to provide new insights that may be helpful in developing improved management strategies for these important pathogens.
authors.affiliation: Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA.
authors.forename: Hossam
authors.initials: H
authors.lastname: Abdelsamed
authors.affiliation: Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA.|Regional Biocontainment Laboratory, University of Tennessee Health Sciences Center, Memphis, TN, USA.
authors.forename: Jan
authors.initials: J
authors.lastname: Peters
authors.affiliation: Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA.|Regional Biocontainment Laboratory, University of Tennessee Health Sciences Center, Memphis, TN, USA.
authors.forename: Gerald I
authors.initials: GI
authors.lastname: Byrne
mesh_terms: D000818:Animals; D002690:Chlamydia Infections / Q000382:microbiology* / Q000473:pathology*; D002692:Chlamydia trachomatis / Q000145:classification* / Q000235:genetics*; D004195:Disease Models, Animal; D014644:Genetic Variation; D054884:Host-Pathogen Interactions; D006801:Humans
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