title: A case of sclerosing angiomatoid nodular transformation of the spleen.
abstract: Sclerosing angiomatoid nodular transformation of the spleen is a rare benign vascular lesion with extensive sclerosis and unknown aetiology. Although its pathogenesis is not clear, it has been postulated that it may represent a peculiar hamartomatous transformation of red pulp in response to an exaggerated non-neoplastic stromal proliferation. However, it is unclear whether SANT is the end stage of a variety of benign splenic conditions including inflammatory pseudotumour, hamartoma or hematoma. Considering that the lesion is benign, splenectomy is curative. We report a new case of SANT, discussing differential diagnosis, immunohistochemical profile and pathogenesis.
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giorlandino
authors.forename: R
authors.initials: R
authors.lastname: Caltabiano
authors.forename: S
authors.initials: S
authors.lastname: Lanzafame
mesh_terms: D000368:Aged; D000798:Angiomatosis / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012598:Sclerosis; D013154:Spleen / Q000473:pathology*; D013158:Splenic Diseases / Q000473:pathology*