title: COX-2-765G>C polymorphism increases the risk of cancer: a meta-analysis.
abstract: BACKGROUND
  Chronic inflammation has been regarded as an important mechanism in carcinogenesis. Inflammation-associated genetic variants have been highly associated with cancer risk. Polymorphisms in the gene cyclooxygenase-2 (COX-2), a pro-inflammation factor, have been suggested to alter the risk of multiple tumors, but the findings of various studies are not consistent.
  
  
  METHODS
  A literature search through February 2013 was performed using PubMed, EMBASE, and CNKI databases. We used odds ratios (ORs) with confidence intervals (CIs) of 95% to assess the strength of the association between the COX-2-765G>C polymorphism and cancer risk in a random-effect model. We also assessed heterogeneity and publication bias.
  
  
  RESULTS
  In total, 65 articles with 29,487 cancer cases and 39,212 non-cancer controls were included in this meta-analysis. The pooled OR (95% CIs) in the co-dominant model (GC vs. GG) was 1.11 (1.02-1.22), and in the dominant model ((CC+GC) vs. GG), the pooled OR was 1.12 (1.02-1.23). In the subgroup analysis, stratified by cancer type and race, significant associations were found between the-765 C allele and higher risk for gastric cancer, leukemia, pancreatic cancer, and cancer in the Asian population.
  
  
  CONCLUSIONS
  In summary, the COX-2-765 C allele was related to increased cancer susceptibility, especially gastric cancer and cancer in the Asian population.
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Ming-zhu
authors.initials: MZ
authors.lastname: Huang
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Rui-xi
authors.initials: RX
authors.lastname: Hua
authors.forename: Wei-jian
authors.initials: WJ
authors.lastname: Guo
mesh_terms: D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D051546:Cyclooxygenase 2
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