title: Hypoxia as a predisposing factor for the development of early onset neonatal thrombocytopenia.
abstract: BACKGROUND
  Thrombocytopenia in hypoxic neonates admitted in NICU is a morbid condition encountered very commonly. Early-onset thrombocytopenia (<72 h) is most commonly associated with fetomaternal conditions complicated by placental insufficiency and/or fetal hypoxia. Chronic intrauterine hypoxia is the most frequent cause of early-onset thrombocytopenia in preterm neonates.
  
  
  OBJECTIVE
  In this study incidence and clinical impact of early thrombocytopenia in hypoxic neonates was investigated.
  
  
  METHODS
  Neonatal intensive care unit of a tertiary level hospital attached to a medical college in Central India. A cross-sectional, observational hospital based study in hypoxic neonates for development of thrombocytopenia.
  
  
  METHODS
  603 hypoxic newborns were evaluated for development of thrombocytopenia. 155 (25.07%) developed thrombocytopenia and were the cases. Non thrombocytopenic babies 448 (74.29%) served as controls. The two groups were compared for birth weight, sex ratio, gestational age, severity of asphyxia, platelet counts and mortality rate.
  
  
  METHODS
  Descriptive statistics of continuous variable were expressed in mean and SD. P value less than or equal to 0.05 were statistically significant.
  
  
  CONCLUSIONS
  We found thrombocytopenia to be associated with male gender, prematurity and low birth weight. Most babies had mild to moderate thrombocytopenia. Mortality was higher in preterm thrombocytopenic babies as compared to term. We suggest screening for thrombocytopenia in all asphyxiated newborns, as hypoxia can lead to neonatal thrombocytopenia.
authors.affiliation: Department of Pediatrics, Gandhi Medical College and Kamla Nehru Hospital, Bhopal, Madhya Pradesh, India.
authors.forename: Jayashree
authors.initials: J
authors.lastname: Nadkarni
authors.forename: Shailendra K
authors.initials: SK
authors.lastname: Patne
authors.forename: Rashmi
authors.initials: R
authors.lastname: Kispotta
keywords: Neonate; birth asphyxia; hypoxia; platelet count; thrombocytopenia
references.citation: Acta Med Okayama. 2008 Oct;62(5):313-7
references.pmid: 18985091
references.citation: J Perinatol. 2005 May;25(5):320-4
references.pmid: 15776003
references.citation: Indian J Pediatr. 1994 Sep-Oct;61(5):551-8
references.pmid: 7744455
references.citation: J Pediatr. 1986 May;108(5 Pt 1):749-55
references.pmid: 3701523
references.citation: Interdiscip Toxicol. 2008 Dec;1(3-4):211-3
references.pmid: 21218117
references.citation: Am J Obstet Gynecol. 2002 Dec;187(6):1605-7
references.pmid: 12501071
references.citation: Pediatr Res. 1996 Jul;40(1):112-9
references.pmid: 8798256
references.citation: Acta Paediatr Suppl. 2002;91(438):74-81
references.pmid: 12477267
references.citation: Am J Perinatol. 2003 Jan;20(1):49-54
references.pmid: 12638081