title: Hybrid assemblies based on a gadolinium-containing polyoxometalate and a cationic polymer with spermine side chains for enhanced MRI contrast agents.
abstract: Supramolecular assembly: Spherical and stable hybrid assemblies based on a cationic polymer with spermine side chains and an anionic Gd(3+)-containing polyoxometalate cluster (GdW) are prepared by electrostatic interaction. The T1-weighted MRI performance of GdW is enhanced about three times in the assemblies; meanwhile, the assemblies show good biocompatibility, which enables them to be promising candidates for MRI contrast agents.
authors.affiliation: Institute of Physical Chemistry, University of Mainz, Jakob-Welder Weg 11, 55099 Mainz (Germany).
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Chai
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Hang
authors.initials: H
authors.lastname: Zhao
authors.forename: Guifeng
authors.initials: G
authors.lastname: Liu
authors.forename: Karl
authors.initials: K
authors.lastname: Fischer
authors.forename: Haolong
authors.initials: H
authors.lastname: Li
authors.forename: Lixin
authors.initials: L
authors.lastname: Wu
authors.forename: Manfred
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D002412:Cations / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D011108:Polymers / Q000737:chemistry*; D013096:Spermine / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
chemical_list: D002412:Cations; D003287:Contrast Media; D005682:Gadolinium; D011108:Polymers; D013096:Spermine; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: cationic polymers; hybrid materials; magnetic resonance imaging; polyoxometalates; self-assembly