title: Targeting Wnt signaling to improve wound healing after myocardial infarction.
abstract: Myocardial infarction is one of the major causes of left ventricular dilatation, frequently leading to heart failure. In the last decade, the wound healing process that takes place in the infarct area after infarction has been recognized as a novel therapeutic target to attenuate left ventricular dilatation and preserve an adequate cardiac function. In this chapter, we discuss the role of Wnt signaling in the wound healing process after infarction, with a specific focus on its modulating effect on myofibroblast characteristics.
authors.affiliation: Department of Pharmacology, CARIM, Maastricht University, Maastricht, The Netherlands.
authors.forename: Evangelos P
authors.initials: EP
authors.lastname: Daskalopoulos
authors.forename: Ben J A
authors.initials: BJ
authors.lastname: Janssen
authors.forename: W Matthijs
authors.initials: WM
authors.lastname: Blankesteijn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D051157:Frizzled Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D058628:Myofibroblasts / Q000187:drug effects / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D020257:Ventricular Remodeling / Q000187:drug effects; D051153:Wnt Proteins / Q000378:metabolism*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D051157:Frizzled Receptors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D051153:Wnt Proteins