title: White-matter connectivity and methylphenidate-induced changes in attentional performance according to α2A-adrenergic receptor gene polymorphisms in Korean children with attention-deficit hyperactivity disorder.
abstract: The authors examined the association between the MspI C/G and DraI C/T genotypes of the α2A-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele at the DraI polymorphism showed fewer changes in the mean commission error scores after 8 weeks of medication and decreased fractional anisotropy (FA) values in the right middle frontal cortex than subjects without the T allele. Subjects with the C allele at the MspI polymorphism showed decreased FA values in the right postcentral gyrus than subjects without.
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.forename: Soon-Beom
authors.initials: SB
authors.lastname: Hong
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Young-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Min-Hyeon
authors.initials: MH
authors.lastname: Park
authors.forename: Boong-Nyun
authors.initials: BN
authors.lastname: Kim
authors.forename: Min-Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Hee-Jeong
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Soo-Churl
authors.initials: SC
authors.lastname: Cho
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D000697:Central Nervous System Stimulants; D018341:Receptors, Adrenergic, alpha-2; D008774:Methylphenidate