title: Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
abstract: Pyrethroid insecticides target voltage-gated sodium channels, which are critical for electrical signaling in the nervous system. The intensive use of pyrethroids in controlling arthropod pests and disease vectors has led to many instances of pyrethroid resistance around the globe. In the past two decades, studies have identified a large number of sodium channel mutations that are associated with resistance to pyrethroids. The purpose of this review is to summarize both common and unique sodium channel mutations that have been identified in arthropod pests of importance to agriculture or human health. Identification of these mutations provides valuable molecular markers for resistance monitoring in the field and helped the discovery of the elusive pyrethroid receptor site(s) on the sodium channel.
authors.affiliation: Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, MI 48824-1115 USA.
authors.forename: Frank D
authors.initials: FD
authors.lastname: Rinkevich
authors.forename: Yuzhe
authors.initials: Y
authors.lastname: Du
authors.forename: Ke
authors.initials: K
authors.lastname: Dong
references.citation: Pest Manag Sci. 2005 Jan;61(1):91-6
references.pmid: 15593078
references.citation: Pest Manag Sci. 2010 Sep;66(9):1031-40
references.pmid: 20564731
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6614-9
references.pmid: 22493253
references.citation: Mol Gen Genet. 1997 Nov;256(6):602-10
references.pmid: 9435785
references.citation: Insect Biochem Mol Biol. 2008 Sep;38(9):883-90
references.pmid: 18692135
references.citation: J Med Entomol. 2002 Nov;39(6):870-4
references.pmid: 12495185
references.citation: Mol Gen Genet. 1996 Aug 27;252(1-2):61-8
references.pmid: 8804404
references.citation: Insect Biochem Mol Biol. 1996 Apr;26(4):319-26
references.pmid: 8814780
references.citation: J Econ Entomol. 2011 Feb;104(1):250-7
references.pmid: 21404865
references.citation: Biochem Biophys Res Commun. 1999 Aug 11;261(3):558-61
references.pmid: 10441465
references.citation: Insect Mol Biol. 2009 Oct;18(5):583-93
references.pmid: 19754737
references.citation: Neuron. 2000 Apr;26(1):13-25
references.pmid: 10798388
references.citation: Insect Mol Biol. 2006 Apr;15(2):157-67
references.pmid: 16640726
references.citation: J Econ Entomol. 2002 Aug;95(4):838-48
references.pmid: 12216829
references.citation: Pest Manag Sci. 2008 Nov;64(11):1126-30
references.pmid: 18561309
references.citation: Biochem J. 2006 Jun 1;396(2):255-63
references.pmid: 16475981
references.citation: Bull Entomol Res. 2011 Aug;101(4):393-405
references.pmid: 21342603
references.citation: Biochim Biophys Acta. 1980 Aug 14;600(3):882-97
references.pmid: 6250606
references.citation: Mini Rev Med Chem. 2002 Aug;2(4):419-32
references.pmid: 12370061
references.citation: Int J Parasitol. 2009 Jun;39(7):775-9
references.pmid: 19367831
references.citation: Med Vet Entomol. 2003 Jun;17(2):138-44
references.pmid: 12823830
references.citation: Insect Mol Biol. 2000 Oct;9(5):491-7
references.pmid: 11029667
references.citation: Mol Pharmacol. 1988 May;33(5):543-50
references.pmid: 2452970
references.citation: Insect Biochem Mol Biol. 2002 Apr;32(4):445-54
references.pmid: 11886779
references.citation: Insect Biochem Mol Biol. 1997 Feb;27(2):93-100
references.pmid: 9066120
references.citation: Insect Biochem Mol Biol. 1997 Jan;27(1):9-13
references.pmid: 9061924
references.citation: Biochem J. 2009 Apr 15;419(2):377-85
references.pmid: 19154185
references.citation: IUBMB Life. 2007 Mar;59(3):151-62
references.pmid: 17487686
references.citation: PLoS One. 2010 Jul 21;5(7):e11681
references.pmid: 20657783
references.citation: PLoS Negl Trop Dis. 2009 Oct 06;3(10):e527
references.pmid: 19806205
references.citation: Insect Biochem Mol Biol. 1997 Aug-Sep;27(8-9):745-55
references.pmid: 9443375
references.citation: Mol Pharmacol. 1997 Apr;51(4):651-7
references.pmid: 9106631
references.citation: FEBS Lett. 2005 Nov 21;579(28):6317-25
references.pmid: 16263118
references.citation: Pest Manag Sci. 2012 Jun;68(6):834-8
references.pmid: 22228578
references.citation: Insect Biochem Mol Biol. 2010 May;40(5):385-93
references.pmid: 20362057
references.citation: Arch Toxicol. 2012 Feb;86(2):165-81
references.pmid: 21710279
references.citation: Biochem Biophys Res Commun. 2000 Nov 30;278(3):516-21
references.pmid: 11095943
references.citation: Insect Biochem Mol Biol. 2003 Jun;33(6):563-77
references.pmid: 12770575
references.citation: Malar J. 2010 May 28;9:146
references.pmid: 20509922
references.citation: J Med Entomol. 2008 Nov;45(6):1092-101
references.pmid: 19058634
references.citation: Pest Manag Sci. 2005 Jun;61(6):549-54
references.pmid: 15657957
references.citation: FEBS Lett. 2007 Nov 27;581(28):5485-92
references.pmid: 17991435
references.citation: Pharmacol Toxicol. 1996 Jul;79(1):1-14
references.pmid: 8841090
references.citation: Pest Manag Sci. 2001 Oct;57(10):877-88
references.pmid: 11695180
references.citation: Insect Biochem Mol Biol. 2006 Nov;36(11):885-9
references.pmid: 17046602
references.citation: Trop Med Int Health. 2011 Apr;16(4):501-9
references.pmid: 21342372
references.citation: Pest Manag Sci. 2005 Nov;61(11):1096-102
references.pmid: 16032654
references.citation: Insect Biochem Mol Biol. 2000 Oct;30(10):991-7
references.pmid: 10899465
references.citation: Med Vet Entomol. 2012 Jun;26(2):228-32
references.pmid: 22070231
references.citation: Dis Aquat Organ. 2005 Jun;65(2):129-36
references.pmid: 16060266
references.citation: Mol Pharmacol. 1988 Jul;34(1):54-9
references.pmid: 2455860
references.citation: Insect Biochem Mol Biol. 2011 Jul;41(7):446-50
references.pmid: 21426938
references.citation: Insect Biochem Mol Biol. 2001 Jan;31(1):19-29
references.pmid: 11102831
references.citation: Biophys J. 1997 Oct;73(4):1885-95
references.pmid: 9336184
references.citation: Mol Pharmacol. 2003 Oct;64(4):914-22
references.pmid: 14500748
references.citation: Insect Biochem Mol Biol. 2012 Jul;42(7):506-13
references.pmid: 22504519
references.citation: Mol Pharmacol. 2005 Feb;67(2):513-22
references.pmid: 15525757
references.citation: Insect Biochem Mol Biol. 1997 Oct;27(10):807-12
references.pmid: 9474777
references.citation: Insect Mol Biol. 1998 May;7(2):191-6
references.pmid: 9535164
references.citation: Aust Vet J. 2011 Mar;89(3):70-2
references.pmid: 21323651
references.citation: Insect Biochem Mol Biol. 2004 Dec;34(12):1305-13
references.pmid: 15544944
references.citation: J Med Entomol. 2012 Sep;49(5):1012-20
references.pmid: 23025181
references.citation: Jpn J Infect Dis. 2011;64(3):217-21
references.pmid: 21617306
references.citation: Insect Mol Biol. 1998 May;7(2):179-84
references.pmid: 9535162
references.citation: Cell. 1989 Sep 22;58(6):1143-54
references.pmid: 2550145
references.citation: Am J Trop Med Hyg. 2004 Jun;70(6):591-6
references.pmid: 15210997
references.citation: Insect Biochem Mol Biol. 2009 Apr;39(4):272-8
references.pmid: 19171193
references.citation: Brain Res. 1988 May 17;448(2):308-12
references.pmid: 2454144
references.citation: Mol Gen Genet. 1996 Aug 27;252(1-2):51-60
references.pmid: 8804403
references.citation: Brain Res. 1988 Aug 30;459(1):44-53
references.pmid: 2844361
references.citation: Malar J. 2006 Jul 05;5:56
references.pmid: 16820067
references.citation: Pest Manag Sci. 2010 Mar;66(3):301-7
references.pmid: 19908228
references.citation: Insect Mol Biol. 2011 Aug;20(4):437-45
references.pmid: 21496128
references.citation: J Gen Physiol. 2000 Mar;115(3):305-18
references.pmid: 10694259
references.citation: Mol Pharmacol. 1999 Mar;55(3):584-93
references.pmid: 10051544
references.citation: Infect Genet Evol. 2012 Mar;12(2):487-91
references.pmid: 22210132
references.citation: Pest Manag Sci. 2008 Jun;64(6):610-6
references.pmid: 18383430
references.citation: J Exp Biol. 2002 Mar;205(Pt 5):575-84
references.pmid: 11907047
references.citation: Insect Biochem Mol Biol. 2008 Mar;38(3):296-306
references.pmid: 18252244
references.citation: Med Vet Entomol. 2003 Mar;17(1):87-94
references.pmid: 12680930
references.citation: J Clin Microbiol. 2012 Jul;50(7):2229-33
references.pmid: 22573588
references.citation: Bull Entomol Res. 2008 Apr;98(2):183-91
references.pmid: 18076786
references.citation: Biochem Biophys Res Commun. 1997 Oct 29;239(3):688-91
references.pmid: 9367829
references.citation: Insect Biochem Mol Biol. 1994 Jul;24(7):647-54
references.pmid: 7915170
references.citation: Insect Biochem Mol Biol. 2002 Dec;32(12):1781-91
references.pmid: 12429130
references.citation: Insect Biochem Mol Biol. 1999 Feb;29(2):185-94
references.pmid: 10196741
references.citation: J Biol Chem. 2009 Dec 4;284(49):33869-75
references.pmid: 19828457
references.citation: Insect Biochem Mol Biol. 2011 Jan;41(1):9-13
references.pmid: 20869441
references.citation: Insect Mol Biol. 1999 Aug;8(3):339-46
references.pmid: 10469251
references.citation: Invert Neurosci. 2007 Mar;7(1):17-30
references.pmid: 17206406
references.citation: Int J Parasitol. 2010 Dec;40(14):1659-64
references.pmid: 20708620
references.citation: Mol Gen Genet. 1993 Jul;240(1):17-22
references.pmid: 8101963
references.citation: Pest Manag Sci. 2010 May;66(5):572-5
references.pmid: 20146259
references.citation: Parasit Vectors. 2010 Jul 21;3(1):59
references.pmid: 20646327
references.citation: Insect Biochem Mol Biol. 2011 Sep;41(9):723-32
references.pmid: 21640822
references.citation: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2483-7
references.pmid: 8146143
references.citation: J Econ Entomol. 2009 Dec;102(6):2296-300
references.pmid: 20069860
references.citation: Insect Biochem Mol Biol. 2002 Apr;32(4):397-404
references.pmid: 11886774
references.citation: Insect Mol Biol. 2007 Dec;16(6):785-98
references.pmid: 18093007
references.citation: Pest Manag Sci. 2011 Aug;67(8):904-12
references.pmid: 21370394
references.citation: Pest Manag Sci. 2011 Aug;67(8):891-7
references.pmid: 21432985