title: Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.
abstract: Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.
authors.affiliation: IRCCS Neuromed, Venafro, Italy.
authors.forename: Miriam
authors.initials: M
authors.lastname: Sciaccaluga
authors.forename: Giuseppina
authors.initials: G
authors.lastname: D'Alessandro
authors.forename: Francesca
authors.initials: F
authors.lastname: Pagani
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ferrara
authors.forename: Nadia
authors.initials: N
authors.lastname: Lopez
authors.forename: Tracy
authors.initials: T
authors.lastname: Warr
authors.forename: Paolo
authors.initials: P
authors.lastname: Gorello
authors.forename: Alessandra
authors.initials: A
authors.lastname: Porzia
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mainiero
authors.forename: Antonio
authors.initials: A
authors.lastname: Santoro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Esposito
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Cantore
authors.forename: Emilia
authors.initials: E
authors.lastname: Castigli
authors.forename: Cristina
authors.initials: C
authors.lastname: Limatola
mesh_terms: D045744:Cell Line, Tumor; D002633:Chemotaxis / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D020239:Receptor Cross-Talk / Q000187:drug effects; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*; D020032:Tyrphostins / Q000494:pharmacology
chemical_list: C527276:CXCR4 protein, human; D019718:Receptors, CXCR4; D020032:Tyrphostins; C106250:6,7-dimethoxy-3-phenylquinoxaline; D020797:Receptor, Platelet-Derived Growth Factor beta
references.citation: Trends Endocrinol Metab. 2005 Jan-Feb;16(1):26-33
references.pmid: 15620546
references.citation: J Neurooncol. 2001 May;52(3):205-15
references.pmid: 11519850
references.citation: Trends Pharmacol Sci. 2007 Dec;28(12):602-7
references.pmid: 18001849
references.citation: Trends Neurosci. 2004 Jan;27(1):48-53
references.pmid: 14698610
references.citation: Biochem Biophys Res Commun. 2012 Jan 20;417(3):1035-40
references.pmid: 22214933
references.citation: Neurochem Int. 2006 Oct;49(5):423-32
references.pmid: 16621164
references.citation: J Neuropathol Exp Neurol. 2006 Jun;65(6):529-39
references.pmid: 16783163
references.citation: Lab Invest. 2006 Dec;86(12):1221-32
references.pmid: 17075581
references.citation: Oncogene. 2006 Aug 10;25(35):4913-22
references.pmid: 16547494
references.citation: J Neurosci. 2008 Jun 4;28(23):5870-8
references.pmid: 18524891
references.citation: J Biol Chem. 2003 Feb 21;278(8):6282-90
references.pmid: 12480944
references.citation: Clin Cancer Res. 2000 Jan;6(1):102-11
references.pmid: 10656438
references.citation: Nat Rev Mol Cell Biol. 2003 Aug;4(8):651-7
references.pmid: 12923527
references.citation: Science. 2007 Oct 12;318(5848):287-90
references.pmid: 17872411
references.citation: Cancer Res. 1991 Apr 15;51(8):2164-72
references.pmid: 2009534
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13513-8
references.pmid: 14595012
references.citation: Exp Cell Res. 2005 Aug 15;308(2):241-53
references.pmid: 15921680
references.citation: Oncogene. 2006 May 4;25(19):2801-6
references.pmid: 16407848
references.citation: J Neurooncol. 2001 Jun;53(2):161-76
references.pmid: 11716068
references.citation: PLoS One. 2009 Nov 13;4(11):e7752
references.pmid: 19915670
references.citation: Genes Dev. 2012 Jun 1;26(11):1247-62
references.pmid: 22661233
references.citation: Cancer Res. 2005 Dec 15;65(24):11392-9
references.pmid: 16357147
references.citation: Cell Tissue Res. 1991 Jul;265(1):73-81
references.pmid: 1655272
references.citation: Biochem Soc Trans. 2003 Dec;31(Pt 6):1220-5
references.pmid: 14641030
references.citation: Oncogene. 2004 Sep 9;23(41):6924-32
references.pmid: 15286717
references.citation: J Neurosci. 2005 Nov 30;25(48):11092-106
references.pmid: 16319309
references.citation: Am J Pathol. 2008 Aug;173(2):545-60
references.pmid: 18599607
references.citation: J Med Chem. 1999 Dec 16;42(25):5120-30
references.pmid: 10602697
references.citation: Cancer Res. 1996 Jan 1;56(1):164-71
references.pmid: 8548759
references.citation: J Huazhong Univ Sci Technolog Med Sci. 2006;26(5):604-6
references.pmid: 17219981
references.citation: Ups J Med Sci. 2012 May;117(2):99-112
references.pmid: 22509804
references.citation: Anticancer Agents Med Chem. 2010 Sep;10(7):543-55
references.pmid: 20950259
references.citation: Adv Exp Med Biol. 2013;986:143-70
references.pmid: 22879068
references.citation: Leukemia. 2009 Oct;23(10):1807-17
references.pmid: 19609283
references.citation: J Cell Sci. 2003 Nov 1;116(Pt 21):4409-17
references.pmid: 13130092
references.citation: Am J Physiol Cell Physiol. 2010 Jul;299(1):C175-84
references.pmid: 20392929
references.citation: J Neurooncol. 1997 Dec;35(3):249-57
references.pmid: 9440023