title: A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child.
abstract: Although antibodies to antigens in the Rh blood group system are common causes of warm autoimmune hemolytic anemia, specificity for only the D antigen is rare in autoimmune hemolysis in pediatric patients. This case reports an anti-D associated with severe hemolytic anemia (Hb = 2.1 g/dL) in a previously healthy 14-month-old child who presented with a 3-day history of low-grade fevers and vomiting. Because of his severe anemia, on admission to the hospital he was found to have altered mental status, metabolic acidosis, abnormal liver function tests, and a severe coagulopathy. He was successfully resuscitated with uncrossmatched units of group O, D- blood, and after corticosteroid therapy he had complete resolution of his anti-D-mediated hemolysis.
authors.affiliation: Bonfils Blood Center, Denver, CO, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Bercovitz
authors.forename: M
authors.initials: M
authors.lastname: Macy
authors.forename: D R
authors.initials: DR
authors.lastname: Ambruso
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity; D003298:Coombs Test; D006801:Humans; D007223:Infant; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D018029:Rho(D) Immune Globulin
chemical_list: D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; C026410:Rho(D) antigen
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