title: Malakoplakia with digestive tract involvement in a pig.
abstract: Malakoplakia is a rare, granulomatous, inflammatory disease that mimics malignant tumors and can affect any organ. Herein is described a case of malakoplakia in a 10-month-old slaughter pig. Diffuse, pleomorphic, round cell infiltrates, mainly histiocytes, with a tumor-like growth pattern at gross examination, infiltrated the stomach, pancreas, omentum, and mesenteric lymph nodes. The histiocytes and multinucleated giant cells had concentric, target-like inclusions known as Michaelis-Gutmann bodies. Microorganisms were not detected by the periodic acid-Schiff reaction, Ziehl-Neelsen, Gram, and Warthin-Starry staining or by electron microscopic and bacteriologic investigations. Porcine circovirus type 2 and porcine reproductive and respiratory syndrome viruses were not detected by immunohistochemistry in the sections examined.
authors.affiliation: Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy daniela.gelmetti@izsler.it.
authors.forename: D
authors.initials: D
authors.lastname: Gelmetti
authors.affiliation: Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Gibelli
authors.affiliation: Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Gelmini
authors.affiliation: Dipartimento di Scienze Veterinarie e Sanità Pubblica, School of Veterinary Medicine, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sironi
mesh_terms: D000818:Animals; D017809:Fatal Outcome; D041981:Gastrointestinal Tract / Q000473:pathology*; D007150:Immunohistochemistry / Q000662:veterinary; D002479:Inclusion Bodies / Q000473:pathology; D007558:Italy; D008198:Lymph Nodes / Q000473:pathology*; D008287:Malacoplakia / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*
keywords: Michaelis-Gutmann bodies; PCV2; PRRS; gastrointestinal; malakoplakia; stomach; swine