title: Development of a software for quantitative evaluation radiotherapy target and organ-at-risk segmentation comparison.
abstract: Modern radiotherapy requires accurate region of interest (ROI) inputs for plan optimization and delivery. Target delineation, however, remains operator-dependent and potentially serves as a major source of treatment delivery error. In order to optimize this critical, yet observer-driven process, a flexible web-based platform for individual and cooperative target delineation analysis and instruction was developed in order to meet the following unmet needs: (1) an open-source/open-access platform for automated/semiautomated quantitative interobserver and intraobserver ROI analysis and comparison, (2) a real-time interface for radiation oncology trainee online self-education in ROI definition, and (3) a source for pilot data to develop and validate quality metrics for institutional and cooperative group quality assurance efforts. The resultant software, Target Contour Testing/Instructional Computer Software (TaCTICS), developed using Ruby on Rails, has since been implemented and proven flexible, feasible, and useful in several distinct analytical and research applications.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Department of Radiology and Neuroscience, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Jayashree
authors.initials: J
authors.lastname: Kalpathy-Cramer
authors.forename: Musaddiq
authors.initials: M
authors.lastname: Awan
authors.forename: Steven
authors.initials: S
authors.lastname: Bedrick
authors.forename: Coen R N
authors.initials: CR
authors.lastname: Rasch
authors.forename: David I
authors.initials: DI
authors.lastname: Rosenthal
authors.forename: Clifton D
authors.initials: CD
authors.lastname: Fuller
mesh_terms: D003194:Computer-Assisted Instruction / Q000379:methods; D020407:Internet; D011785:Quality Assurance, Health Care / Q000379:methods; D018787:Radiation Oncology / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012984:Software
references.citation: Radiat Oncol. 2011 Aug 19;6:97
references.pmid: 21854585
references.citation: Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):725-32
references.pmid: 22444999
references.citation: Int J Comput Assist Radiol Surg. 2011 Jan;6(1):111-7
references.pmid: 20499194
references.citation: Strahlenther Onkol. 2012 Jan;188(1):97-9
references.pmid: 22234506
references.citation: Radiother Oncol. 2009 Mar;90(3):285-90
references.pmid: 19038468
references.citation: Phys Med Biol. 2008 Sep 21;53(18):5193-205
references.pmid: 18728311
references.citation: Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):435-48
references.pmid: 16198064
references.citation: IEEE Trans Med Imaging. 2004 Jul;23(7):903-21
references.pmid: 15250643
references.citation: Radiother Oncol. 2012 Jan;102(1):14-21
references.pmid: 21903287
references.citation: Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):416-23
references.pmid: 18538494
references.citation: Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):492; author reply 492
references.pmid: 22182718
references.citation: Radiat Oncol. 2012 Mar 13;7:32
references.pmid: 22414264
references.citation: Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1442-57
references.pmid: 20934273
references.citation: Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):944-51
references.pmid: 19215827
references.citation: Expert Rev Anticancer Ther. 2005 Jun;5(3):501-14
references.pmid: 16001957
references.citation: J Digit Imaging. 2011 Oct;24(5):794-803
references.pmid: 20978922
references.citation: J Med Phys. 2008 Oct;33(4):136-40
references.pmid: 19893706
references.citation: Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e525-8
references.pmid: 21676552
references.citation: Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):986-93
references.pmid: 22138459
references.citation: Radiat Oncol. 2010 Mar 15;5:21
references.pmid: 20230613
references.citation: Int J Gynecol Cancer. 2010 Jan;20(1):47-53
references.pmid: 20130502
references.citation: J Thorac Oncol. 2011 Jul;6(7 Suppl 3):S1743-8
references.pmid: 21847057
references.citation: Curr Oncol Rep. 2006 Mar;8(2):140-5
references.pmid: 16507224
references.citation: Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):481-9
references.pmid: 20400244
references.citation: Lancet Oncol. 2012 Jul;13(7):e292-300
references.pmid: 22748268
references.citation: Phys Med Biol. 2006 Jul 7;51(13):R363-79
references.pmid: 16790913
references.citation: Med Image Anal. 2012 Aug;16(6):1259-79
references.pmid: 22705289
references.citation: Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):747-55
references.pmid: 18455324
references.citation: Int J Radiat Oncol Biol Phys. 2012 Aug 1;83(5):1455-62
references.pmid: 22401917
references.citation: AMIA Annu Symp Proc. 2011;2011:654-63
references.pmid: 22195121
references.citation: Anticancer Res. 2007 Jul-Aug;27(4C):2965-71
references.pmid: 17695480
references.citation: Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):10-8
references.pmid: 20421148
references.citation: Radiother Oncol. 2005 Nov;77(2):182-90
references.pmid: 16256231
references.citation: Radiother Oncol. 2003 Apr;67(1):87-95
references.pmid: 12758244
references.citation: Radiother Oncol. 2011 Jul;100(1):150-6
references.pmid: 21722980
references.citation: Radiother Oncol. 2009 Jun;91(3):455-60
references.pmid: 19339069
references.citation: J Clin Oncol. 2010 Jun 20;28(18):2996-3001
references.pmid: 20479390
references.citation: Clin Cancer Res. 2009 Sep 15;15(18):5663-70
references.pmid: 19723641
references.citation: Br J Radiol. 2009 Jul;82(979):585-94
references.pmid: 19332518
references.citation: Hematol Oncol Clin North Am. 2006 Feb;20(1):45-62
references.pmid: 16580556
references.citation: IEEE Trans Med Imaging. 2006 Nov;25(11):1451-61
references.pmid: 17117774
references.citation: Int J Comput Assist Radiol Surg. 2012 May;7(3):445-54
references.pmid: 21706302
references.citation: Int J Radiat Oncol Biol Phys. 1998 Sep 1;42(2):277-88
references.pmid: 9788405
references.citation: Semin Radiat Oncol. 2004 Jan;14(1):52-64
references.pmid: 14752733
references.citation: Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):901-8
references.pmid: 22483737
references.citation: Br J Radiol. 1997 Nov;70 Spec No:S25-31
references.pmid: 9534715
references.citation: Important Adv Oncol. 1995;:95-109
references.pmid: 7672816
references.citation: Radiother Oncol. 2010 Dec;97(3):567-71
references.pmid: 20864198
references.citation: Radiother Oncol. 2010 Dec;97(3):572-8
references.pmid: 20708285
references.citation: Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1166-70
references.pmid: 19836158
references.citation: Science. 1960 Oct 21;132(3434):1115-8
references.pmid: 17790723
references.citation: Med Phys. 1995 Nov;22(11 Pt 2):1911-21
references.pmid: 8587545
references.citation: Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):348-55
references.pmid: 20472347
references.citation: Br J Radiol. 2003 Oct;76(910):678-89
references.pmid: 14512327