title: Flavonoid-metal ion complexes: a novel class of therapeutic agents.
abstract: Flavonoids are among the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. However, the biological significance of these flavonoid-metal ion complexes is yet to be completely explored. Moreover, no concerted efforts have been made to elucidate their molecular targets and mechanisms of action. This review attempts to provide a snapshot of the various biological activities reported for flavonoid-metal ion complexes and their potential as therapeutic agents. Understanding the mechanism of action and the influence of structure will provide a strong basis to design novel flavonoid-metal ion complexes of therapeutic significance.
authors.affiliation: Centre for Nanotechnology and Advanced Biomaterials, School of Chemical and Biotechnology, SASTRA University, Thanjavur, 613 401, India.
authors.forename: Stalin
authors.initials: S
authors.lastname: Selvaraj
authors.forename: Sridharan
authors.initials: S
authors.lastname: Krishnaswamy
authors.forename: Venkappayya
authors.initials: V
authors.lastname: Devashya
authors.forename: Swaminathan
authors.initials: S
authors.lastname: Sethuraman
authors.forename: Uma Maheswari
authors.initials: UM
authors.lastname: Krishnan
mesh_terms: D000818:Animals; D001665:Binding Sites; D056831:Coordination Complexes / Q000627:therapeutic use*; D004247:DNA / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007477:Ions; D008670:Metals / Q000627:therapeutic use*
chemical_list: D056831:Coordination Complexes; D005419:Flavonoids; D007477:Ions; D008670:Metals; D004247:DNA
keywords: SOD mimic; antimicrobial activity; antioxidant; antitumor; flavonoid; flavonoid-metal ion complex; insulin-mimic activity