title: A novel technology: percutaneous injection of fibrin glue as a treatment for frontal sinus cerebrospinal fluid rhinorrhea.
abstract: In this study, we examined the effectiveness of percutaneous injected fibrin glue as a treatment for frontal sinus cerebrospinal fluid (CSF) rhinorrhea in a series of 4 cases. All 4 patients had fracture in the posterior wall of the frontal sinus. The anterior wall of the frontal sinus was punctured following high-resolution computed tomography imaging. In 3 out of 4 patients with defective skull due to prior frontal craniotomy, direct percutaneous puncture of the frontal sinus was used. Fibrin glue was injected to close the fistula and to seal the rhinorrhea. Surgery procedures lasted for 15-35 minutes (average 27.6 min). Rhinorrhea was stopped in all patients after the surgery, with no recurrence at a 10-month follow-up visit. In 1 case, the glue was expelled by coughing at 2 days after the surgery but was completely stopped with no recurrence after a second attempt. One patient with no recurrence at a 10-month follow-up died of tumor relapse at 12 months. In summary, fibrin glue could be used as a novel treatment for frontal sinus CSF rhinorrhea.
authors.affiliation: From the *Department of Human Anatomy, Hebei Medical University, Shijiazhuang; and †Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Yang
authors.forename: Jianliang
authors.initials: J
authors.lastname: Wu
authors.forename: Gengshen
authors.initials: G
authors.lastname: Zhang
authors.forename: Zongmao
authors.initials: Z
authors.lastname: Zhao
authors.forename: Zhenzeng
authors.initials: Z
authors.lastname: Fan
authors.forename: Baozhi
authors.initials: B
authors.lastname: Wang
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D002559:Cerebrospinal Fluid Rhinorrhea / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D003399:Craniotomy; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005626:Frontal Sinus / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012887:Skull Fractures / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive