title: Tropomyosin-receptor-kinases signaling in the nervous system.
abstract: The development and function of the nervous system is dependent on many growth factors and their signaling. Tropomyosin-receptor-kinase receptor family controls synaptic strength and plasticity in the mammalian nervous system. Dysregulation of Tropomyosin-receptor-kinase receptors signaling can lead to neural developmental disorders and has been reported in certain diseases of the nervous system. Apart from their role in the nervous system, these tyrosine kinase receptors are also involved in cancer biology. Tropomyosin-receptor-kinases and their ligands, neurotrophins, are also involved in neural precursor stem cells differentiation. This review focuses on Tropomyosin-receptor-kinases, the most abundant receptors in mammalian nervous system.
authors.affiliation: University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Romania ; Equal Contribution.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Stoleru
authors.forename: Alisa Madalina
authors.initials: AM
authors.lastname: Popescu
authors.forename: Daniela Elise
authors.initials: DE
authors.lastname: Tache
authors.forename: Oana Maria
authors.initials: OM
authors.lastname: Neamtu
authors.forename: Ghazaleh
authors.initials: G
authors.lastname: Emami
authors.forename: Ligia Gabriela
authors.initials: LG
authors.lastname: Tataranu
authors.forename: Alice Sandra
authors.initials: AS
authors.lastname: Buteica
authors.forename: Anica
authors.initials: A
authors.lastname: Dricu
authors.forename: Stefana Oana
authors.initials: SO
authors.lastname: Purcaru
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