title: Drug-induced liver injury after allogeneic bone marrow transplantation.
abstract: A 23-year-old woman developed acute severe hepatitis and jaundice on day 183 after bone marrow transplantation from HLA-B antigen mismatched-related donor. The administration of prednisolone and cessation of the prescribed drugs resolved the liver injury. Drug lymphocyte stimulation test was positive for acyclovir, and liver biopsy indicated the characteristics of drug-induced liver injury (DILI) rather than graft-versus-host disease. Physicians should keep DILI in mind when considering differential diagnosis for liver complications after allogeneic cell transplantation.
authors.affiliation: Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan, tcbnt@yokohama-cu.ac.jp.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Akito
authors.initials: A
authors.lastname: Nozaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Enaka
authors.forename: Eri
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Rika
authors.initials: R
authors.lastname: Kawasaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Koharazawa
authors.forename: Maki
authors.initials: M
authors.lastname: Hagihara
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishibashi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Naoto
authors.initials: N
authors.lastname: Tomita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Shin
authors.initials: S
authors.lastname: Fujisawa
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008099:Liver / Q000473:pathology; D019172:Transplantation Conditioning / Q000009:adverse effects; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents
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