title: The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing.
abstract: Portal vein glucose sensors detect variations in glycemia to induce a nervous signal that influences food intake and glucose homeostasis. Previous experiments using high infusions of glucose suggested a metabolic sensing involving glucose transporter 2 (GLUT2). Here we evaluated the afferent route for the signal and candidate molecules for detecting low glucose fluxes. Common hepatic branch vagotomy did not abolish the anorectic effect of portal glucose, indicating dorsal transmission. GLUT2-null mice reduced their food intake in response to portal glucose signal initiated by protein-enriched diet. A similar response of Trpm5-null mice and portal infusions of sweeteners also excluded sugar taste receptors. Conversely, infusions of alpha-methylglucose, but not 3-O-methylglucose, decreased food intake, while phlorizin prevented the effect of glucose. This suggested sensing through SGLT3, which was expressed in the portal area. From these results we propose a finely tuned dual mechanism for portal glucose sensing that responds to different physiological conditions.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U 855, Lyon 69372, France ; Université de Lyon, Lyon 69008, France ; Université Lyon 1, Villeurbanne 69622, France ; AgroParisTech, ENGREF, Paris F-75732, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Delaere
authors.forename: Adeline
authors.initials: A
authors.lastname: Duchampt
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mounien
authors.forename: Pascal
authors.initials: P
authors.lastname: Seyer
authors.forename: Céline
authors.initials: C
authors.lastname: Duraffourd
authors.forename: Carine
authors.initials: C
authors.lastname: Zitoun
authors.forename: Bernard
authors.initials: B
authors.lastname: Thorens
authors.forename: Gilles
authors.initials: G
authors.lastname: Mithieux
keywords: (3-O-MDG), 3-O-methyl-d-glucopyranose; (5-HT), 5-hydroxytryptamin/serotonin; (EGP), endogenous glucose production; (G6PC), glucose-6-phosphatase catalytic subunit; (GAPDH), glyceraldehyde-3-phosphate dehydrogenase; (GFAP), glial fibriallary acidic protein; (GLP1), glucagon-like peptide 1; (GLUT), glucose transporter; (PED), protein-enriched diet; (PGP9.5), protein gene product 9.5; (SED), starch-enriched diet; (SGLT), sodium glucose co-transporter; (Trpm5), transient receptor potential melastin 5; (αMDG), α-methylglucopyranoside; Food intake; Glucose metabolism; Glucose sensing; Peripheral nervous signal; Portal vein; SGLTs
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