title: Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts.
abstract: Endogenous electrophiles, such as α,β-unsaturated aldehydes and ketones generated during lipid peroxidation, exhibit a facile reactivity with proteins, generating a variety of intra and intermolecular covalent adducts. It has been postulated that these host-derived, modified proteins with electrophiles, which constitute the products of diverse classes of oxidative reactions, represent damage-associated molecular patterns (DAMPs). The DAMPs, that occur in vivo, can be a ligand of multiple proteins, which in turn, may lead to the profound innate and adaptive immune responses and mediate homeostatic functions consequent to inflammation and cell death.
authors.affiliation: Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008024:Ligands; D015227:Lipid Peroxidation / Q000276:immunology*; D010084:Oxidation-Reduction; D011506:Proteins / Q000276:immunology*
chemical_list: D008024:Ligands; D011506:Proteins
keywords: Covalent modification of proteins; Damage-associated molecular patterns; Electrophiles; Innate immunity; Lipid peroxidation; Pattern recognition receptors
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