title: Surveillance of bacterial and fungal infections in the postoperative period following liver transplantation: a series from 2005-2011.
abstract: Orthotopic liver transplantation (OLT) is a life-saving procedure for the treatment of many end-stage diseases, but infectious and acute rejection episodes remain major causes of morbidity and mortality. Bacterial and fungal infections can be due to intra-abdominal, biliary, respiratory, urinary, wound, central venous catheters (CVC) or unknown sources. Using the computerized database of our microbiology laboratory, we analyzed all the bacterial and fungal infections in the first three months following OLT among 151 consecutive adult recipients at single center between January 2005 and December 2011. Samples included blood, bile CVC, urine, and bronchoalveolar lavage (BAL) specimen. Culture and identification of the isolated microorganisms was done in accordance with standard microbiological procedures. Three hundred thirteen samples from the above sites showed positive results for gram-positive cocci (n = 137; 43.8%), gram-negative rods (n = 156; 49.8%), and Candida species (n = 19; 6.1%). One patient (0.3%) experienced a CVC-related infection caused by Fusarium oxysporum. Bacterial and particularly biliary tract infections seem to play major roles in morbidity and mortality in the first three months following OLT. The major contributors to patient morbidity and mortality were candidemia and/or invasive candidiasis mainly from the biliary tract and/or CVC-related infections.
authors.affiliation: Department of Surgery, Division of General Surgery and Organ Transplantation, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: gsganga@tiscali.it.
authors.forename: G
authors.initials: G
authors.lastname: Sganga
authors.forename: G
authors.initials: G
authors.lastname: Bianco
authors.forename: B
authors.initials: B
authors.lastname: Fiori
authors.forename: E
authors.initials: E
authors.lastname: Nure
authors.forename: T
authors.initials: T
authors.lastname: Spanu
authors.forename: M C
authors.initials: MC
authors.lastname: Lirosi
authors.forename: F
authors.initials: F
authors.lastname: Frongillo
authors.forename: S
authors.initials: S
authors.lastname: Agnes
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D009181:Mycoses / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D011184:Postoperative Period