title: Triazole-containing hydrogels for time-dependent sustained drug release.
abstract: The purpose of this study is to develop novel triazole-containing hydrogels (TGs) as drug carrier and to investigate the sustained drug release accomplished by their time-dependent swelling behavior. The synthetic pathway of TGs includes: (1) DCC-coupling on hydroxyethyl methacrylate (HEMA) to prepare HEMA-alkyne (HA), (2) click-coupling to prepare a triazole-ring-containing monomer (TM), and (3) the synthesis of a series of TGs. The aggregation between triazole rings is found to be responsible for drug release controllability. Rhodamine 6G is studied as a model anticancer drug for release experiments. The effects of pH and temperature on the properties of sustained drug release are also studied.
authors.affiliation: Department of Chemistry, University of Ulsan, Ulsan, 680-749, Republic of Korea.
authors.forename: Vivek
authors.initials: V
authors.lastname: Mishra
authors.forename: Seo-Hyun
authors.initials: SH
authors.lastname: Jung
authors.forename: Jong Mok
authors.initials: JM
authors.lastname: Park
authors.forename: Han Mo
authors.initials: HM
authors.lastname: Jeong
authors.forename: Hyung-Il
authors.initials: HI
authors.lastname: Lee
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D057930:Click Chemistry; D004337:Drug Carriers / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D012235:Rhodamines; D014230:Triazoles; C026188:rhodamine 6G
keywords: DMAEMA; anticancer; hydrogels; sustained release; triazole