title: ERCC1 expression levels predict the outcome of platinum-based chemotherapies in advanced bladder cancer: a meta-analysis.
abstract: The objective of this study was to provide a precise evaluation of whether expression levels of excision repair cross-complementation group 1 (ERCC1) are associated with objective response, overall survival (OS), and median survival in patients with advanced bladder cancer treated with platinum-based chemotherapy. Systematic computerized searches of the electronic databases PubMed, EMBASE, Ovid, ASCO, and CNKI were performed and a meta-analysis was carried out to evaluate the correlation between ERCC1 expression levels and objective response rate, OS, or progression-free survival in patients with advanced bladder cancer receiving platinum-based chemotherapy. References within the articles identified were also searched manually. STATA package version 11.0 was used for the comprehensive quantitative analyses. A total of six studies involving 356 patients, of which ERCC1 expression was high/positive in 138 (38.8%) and low/negative in 218 (61.2%), were included in the meta-analysis. The median age of the patients was 63.7 years. The objective response rate favored patients with ERCC1 low/negative expression after platinum-based chemotherapy, but showed no significant difference [odds ratio 0.86, 95% confidence interval (CI) 0.36-2.06, P=0.734]. The median OS time and the median progression-free survival time were significantly prolonged when ERCC1 low/negative expression was compared with ERCC1 high/positive expression (hazard ratio 0.69, 95% CI 0.54-0.89, P=0.004, and hazard ratio 0.76, 95% CI 0.66-0.89, P=0.000, respectively). In conclusion, low/negative expression of ERCC1 was associated with higher objective response, median progression-free survival, and median OS in patients with advanced bladder cancer treated with platinum-based chemotherapy. ERCC1 may be a suitable marker of prognosis and sensitivity to platinum-based chemotherapy in patients with advanced bladder cancer. Larger studies and further clinical trials are warranted to confirm these findings.
authors.affiliation: Departments of aClinical Laboratory bTraditional Chinese Medicine cColorectal & Anal Surgery dResearch Administration eOrthopaedic Trauma Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Junrong
authors.initials: J
authors.lastname: Wu
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Chen
authors.forename: Weizhong
authors.initials: W
authors.lastname: Tang
authors.forename: Qiliu
authors.initials: Q
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.forename: Ruolin
authors.initials: R
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Jinmin
authors.initials: J
authors.lastname: Zhao
mesh_terms: D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D018572:Disease-Free Survival; D004720:Endonucleases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010984:Platinum / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D010984:Platinum; C071447:ERCC1 protein, human; D004720:Endonucleases