title: Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging.
abstract: A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.
authors.affiliation: Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000 Bahía Blanca, Argentina. Electronic address: avascon@criba.edu.ar.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vasconsuelo
authors.forename: Lorena
authors.initials: L
authors.lastname: Milanesi
authors.forename: Ricardo
authors.initials: R
authors.lastname: Boland
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004958:Estradiol / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D013739:Testosterone; D004958:Estradiol
keywords: 17β-estradiol; Aging; Androgen receptor; Estrogen receptor; Mitochondria; Testosterone