title: The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid neoplasms and de novo myelodysplastic syndromes.
abstract: Therapy-related myeloid neoplasms (t-MNs) are an increasingly recognized complication in patients previously treated with radiotherapy and/or chemotherapy for cancer or autoimmune disease. Single nucleotide variants (SNVs) in genes involved in the cellular pathways of detoxification, DNA repair and apoptosis may modify the individual risk of developing a t-MN. We studied the frequency of the SNVs of six genes involved in xenobiotic detoxification (CYP3A4, NQO1, GSTA1, GSTM1, GSTP1 and GSTT1), two DNA repair genes (RAD51 and XRCC3) and one key regulator of apoptosis (BCL2L10) in a case-control study including 111 cases of t-MN and 259 controls. This is the first report on the prevalence of BCL2L10 Leu21Arg polymorphism in myeloid malignancies. In this line, we also tested 146 cases of de novo myelodysplastic syndrome (MDS) and 109 cases of de novo acute myeloid leukemia (AML). Our results showed a significantly lower frequency of the BCL2L10-21Arg allele in patients with t-MN and de novo MDS compared to controls (Leu/Arg + Arg/Arg: 50.6% vs. 65.9%, p = 0.017 and 45.8% vs. 65.9%, p = 0.0003, respectively). Carriers of the BCL2L10-21Arg variant have a reduced risk of developing t-MN and de novo MDS.
authors.affiliation: Institute of Hematology, Università Cattolica Sacro Cuore , Rome , Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Fabiani
authors.forename: Luana
authors.initials: L
authors.lastname: Fianchi
authors.forename: Giulia
authors.initials: G
authors.lastname: Falconi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Boncompagni
authors.forename: Marianna
authors.initials: M
authors.lastname: Criscuolo
authors.forename: Francesco
authors.initials: F
authors.lastname: Guidi
authors.forename: Antonella
authors.initials: A
authors.lastname: La Brocca
authors.forename: Stefan
authors.initials: S
authors.lastname: Hohaus
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Voso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution; D001853:Bone Marrow / Q000473:pathology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D012306:Risk; D055815:Young Adult
chemical_list: C117144:BCL2-like 10 protein; D019253:Proto-Oncogene Proteins c-bcl-2
keywords: BCL2L10; apoptosis; myelodysplastic syndrome; polymorphisms; therapy-related myeloid neoplasms