title: Intestinal-type adenocarcinoma of the larynx: Report of a rare aggressive phenotype and discussion of histogenesis.
abstract: BACKGROUND
  Primary laryngeal adenocarcinomas are uncommon and typically of salivary or seromucinous glands origin. Similarly, metastatic adenocarcinoma, including intestinal origin to the larynx, is a rare occurrence.
  
  
  METHODS
  We present a case of a 63-year-old woman with odynophagia and an epiglottic mass of 2 months' duration. Physical examination revealed a large mass involving the entire epiglottis with extension to the preepiglottic space anteriorly and to the right lateral wall of the oropharyngeal/hypopharyngeal junction.
  
  
  RESULTS
  Induction chemotherapy was initiated, and, after 4 cycles with no noticeable response, the patient underwent total laryngectomy and bilateral levels II to IV neck dissection. The final pathology diagnosis was primary intestinal-type adenocarcinoma of the larynx.
  
  
  CONCLUSIONS
  We present a primary high-stage intestinal-type adenocarcinoma of the larynx and discuss its putative origin and the clinicopathologic characteristics.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Diana
authors.initials: D
authors.lastname: Bell
authors.forename: Floyd Christopher
authors.initials: FC
authors.lastname: Holsinger
authors.forename: Nelson
authors.initials: N
authors.lastname: Ordonez
authors.forename: Adel K
authors.initials: AK
authors.lastname: El-Naggar
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D001707:Biopsy, Needle; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D008875:Middle Aged; D037981:Neck Dissection / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010641:Phenotype; D049268:Positron-Emission Tomography / Q000379:methods; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: intestinal-type; larynx; metastatic carcinoma; primary adenocarcinoma