title: Endurance exercise alters cellular immune status and resistin concentrations in men suffering from non-insulin-dependent type 2 diabetes.
abstract: It has been demonstrated that alterations of adipocytokines can alter immune status in type 2 diabetes. The present study investigated changes of adipocytokine plasma concentrations and cellular immune status in overweight men, suffering from non-insulin dependent type 2 diabetes (n=14, age 61.0±8.7 years, BMI 31.1±3.5 kg/cm2). Subjects underwent a 3 months endurance exercise intervention (twice per week for up to 45 min) cycling at a heart rate corresponding to a 2 mmol/l lactate threshold. Before and after the intervention testing for adipocytokines (leptin, adiponectin, resistin) and cellular immune status (including T memory-cells and regulative T-cells) was performed by RIA and FACS accordingly.The exercise intervention improved anthropometric and metabolic parameters of all subjects. We observed a significant decline for resistin and for the CD19+ B-cells. The CD4+CD25+CD127low Treg-cells decreased, however not statistically significant. All other parameters remained unchanged.In conclusion, even though only training twice a week, the exercise affected parts of the cellular immune system as well as resistin levels in men suffering from non-insulin dependent type 2 diabetes.
authors.affiliation: Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Wenning
authors.forename: T
authors.initials: T
authors.lastname: Kreutz
authors.forename: A
authors.initials: A
authors.lastname: Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Opitz
authors.forename: C
authors.initials: C
authors.lastname: Graf
authors.forename: S
authors.initials: S
authors.lastname: Voss
authors.forename: W
authors.initials: W
authors.lastname: Bloch
authors.forename: K
authors.initials: K
authors.lastname: Brixius
mesh_terms: D054392:Adipokines / Q000097:blood; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000276:immunology / Q000628:therapy; D010807:Physical Endurance / Q000502:physiology*; D052243:Resistin / Q000097:blood*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; C499624:RETN protein, human; D052243:Resistin