title: Risk factors for inflammatory breast cancer and other invasive breast cancers.
abstract: BACKGROUND
  We investigated risk factors for inflammatory breast cancer (IBC), a rare, aggressive, and poorly understood breast cancer that is characterized by diffuse breast skin erythema and edema.
  
  
  METHODS
  We included 617 IBC case subjects in a nested case-control study from the Breast Cancer Surveillance Consortium database (1994-2009). We also included 1151 noninflammatory, locally advanced, invasive breast cancers with chest wall/breast skin involvement (LABC), 7600 noninflammatory invasive case subjects without chest wall/breast skin involvement (BC), and 93 654 control subjects matched to case subjects on age and year at diagnosis and mammography registry. We present estimates of rate ratios (RRs) and 95% confidence intervals (CI) from conditional logistic regression analyses for each case group vs control subjects based on multiply imputed datasets.
  
  
  RESULTS
  First-degree family history of breast cancer and high mammographic breast density increased risk of IBC, LABC, and BC. High body mass index (BMI) increased IBC risk irrespective of menopausal status and estrogen receptor (ER) expression; rate ratios for BMI 30 and greater vs BMI less than 25 were 3.90 (95% CI = 1.50 to 10.14) in premenopausal women and 3.70 (95% CI = 1.98 to 6.94) in peri/postmenopausal women not currently using hormones. BMI 30 and greater slightly increased risk of ER-positive BC (RR = 1.40; 95% CI = 1.11 to 1.76). Statistically significant reductions in risk of ER-negative IBC with older age at first birth and of ER-positive IBC with higher education were not seen for LABC and BC of the same ER status.
  
  
  CONCLUSIONS
  Different associations with BMI, age at first birth, and education between IBC and/or LABC and BC suggest a distinct etiology for IBC.
authors.affiliation: Affiliations of authors: Joint Program for Survey Methodology, University of Maryland, College Park, MD (YL); Group Health Research Institute, Group Health Cooperative, Seattle, WA (PF, RDW, DSMB, DLM); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (CS, BIG, WFA); Departments of Medicine and Epidemiology/Biostatistics University of California-San Francisco, San Francisco, CA (KK); Dartmouth Medical School, Hanover, NH (TLO); Department of Public Health Sciences, University of California Davis School of Medicine, Davis, CA (DLM).
authors.forename: Catherine
authors.initials: C
authors.lastname: Schairer
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Peter
authors.initials: P
authors.lastname: Frawley
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
authors.forename: Robert D
authors.initials: RD
authors.lastname: Wellman
authors.forename: Diana S M
authors.initials: DS
authors.lastname: Buist
authors.forename: Karla
authors.initials: K
authors.lastname: Kerlikowske
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Onega
authors.forename: William F
authors.initials: WF
authors.lastname: Anderson
authors.forename: Diana L
authors.initials: DL
authors.lastname: Miglioretti
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000737:chemistry / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D036801:Parturition; D017698:Postmenopause; D017697:Premenopause; D011960:Receptors, Estrogen / Q000032:analysis*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D011960:Receptors, Estrogen
references.citation: AJR Am J Roentgenol. 1997 Oct;169(4):1001-8
references.pmid: 9308451
references.citation: J Clin Oncol. 2003 Jun 15;21(12):2254-9
references.pmid: 12805323
references.citation: Nature. 2000 Aug 17;406(6797):747-52
references.pmid: 10963602
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1558-68
references.pmid: 15466970
references.citation: Clin Cancer Res. 2007 May 15;13(10):2825-30
references.pmid: 17504979
references.citation: Urology. 2005 May;65(5):1013-8
references.pmid: 15882755
references.citation: J Clin Oncol. 1998 Dec;16(12):3731-5
references.pmid: 9850015
references.citation: Ann Epidemiol. 2012 May;22(5):340-8
references.pmid: 22366170
references.citation: Breast Dis. 2005-2006;22:9-23
references.pmid: 16735783
references.citation: Clin Cancer Res. 2013 Sep 1;19(17):4685-96
references.pmid: 23396049
references.citation: World Health Organ Tech Rep Ser. 1995;854:1-452
references.pmid: 8594834
references.citation: Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):155-65
references.pmid: 22028401
references.citation: Br J Nutr. 2004 Sep;92(3):347-55
references.pmid: 15469638
references.citation: J Natl Cancer Inst. 2011 Aug 3;103(15):1179-89
references.pmid: 21795664