title: Dose optimization approach to fast X-ray microtomography of the lung alveoli.
abstract: A basic prerequisite forin vivoX-ray imaging of the lung is the exact determination of radiation dose. Achieving resolutions of the order of micrometres may become particularly challenging owing to increased dose, which in the worst case can be lethal for the imaged animal model. A framework for linking image quality to radiation dose in order to optimize experimental parameters with respect to dose reduction is presented. The approach may find application for current and futurein vivostudies to facilitate proper experiment planning and radiation risk assessment on the one hand and exploit imaging capabilities on the other.
authors.affiliation: Swiss Light Source, Paul Scherrer Institute, 5234 Villigen, Switzerland ; Institute for Biomedical Engineering, University and ETH Zurich, 8092 Zurich, Switzerland.
authors.forename: Goran
authors.initials: G
authors.lastname: Lovric
authors.forename: Sébastien F
authors.initials: SF
authors.lastname: Barré
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Schittny
authors.forename: Matthias
authors.initials: M
authors.lastname: Roth-Kleiner
authors.forename: Marco
authors.initials: M
authors.lastname: Stampanoni
authors.forename: Rajmund
authors.initials: R
authors.lastname: Mokso
keywords: X-ray microtomography; dose optimization; lung aveoli; radiation dose
references.citation: Crit Care Med. 2009 Sep;37(9):2604-11
references.pmid: 19623041
references.citation: Phys Med Biol. 2008 Feb 7;53(3):775-91
references.pmid: 18199914
references.citation: Phys Med Biol. 2004 Aug 21;49(16):3573-83
references.pmid: 15446788
references.citation: Eur J Radiol. 2008 Dec;68(3 Suppl):S78-83
references.pmid: 18606518
references.citation: J Appl Physiol (1985). 2009 Jun;106(6):1949-58
references.pmid: 19359611
references.citation: J Synchrotron Radiat. 2009 Mar;16(Pt 2):143-51
references.pmid: 19240326
references.citation: J Synchrotron Radiat. 2012 Nov;19(Pt 6):1029-37
references.pmid: 23093766
references.citation: J Microsc. 2002 Apr;206(Pt 1):33-40
references.pmid: 12000561
references.citation: Med Phys. 1999 Oct;26(10):2190-3
references.pmid: 10535637
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L246-54
references.pmid: 18032698
references.citation: Phys Med Biol. 2005 Nov 7;50(21):5031-40
references.pmid: 16237239
references.citation: J R Soc Interface. 2012 Sep 7;9(74):2213-24
references.pmid: 22491972
references.citation: Phys Med Biol. 2001 Dec;46(12):3287-99
references.pmid: 11768506
references.citation: Ann Biomed Eng. 2012 May;40(5):1160-9
references.pmid: 22189492
references.citation: Br J Radiol. 2005 Nov;78(935):1018-27
references.pmid: 16249603
references.citation: Phys Med Biol. 2008 Aug 21;53(16):4285-301
references.pmid: 18653926
references.citation: J Synchrotron Radiat. 2010 Sep;17(5):590-9
references.pmid: 20724780
references.citation: Science. 1987 Sep 18;237(4821):1439-44
references.pmid: 17816787
references.citation: Clin Exp Pharmacol Physiol. 2009 Jan;36(1):117-25
references.pmid: 19205087
references.citation: Phys Med Biol. 2004 Sep 21;49(18):4335-48
references.pmid: 15509069
references.citation: PLoS One. 2011 Feb 25;6(2):e17400
references.pmid: 21364899
references.citation: J Appl Physiol (1985). 2009 Mar;106(3):757-65
references.pmid: 19074576
references.citation: Yonsei Med J. 2009 Jun 30;50(3):422-6
references.pmid: 19568606