title: Association of slow acetylation profile of NAT2 with breast and gastric cancer risk in Brazil.
abstract: BACKGROUND
  The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil.
  
  
  METHODS
  Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM).
  
  
  RESULTS
  Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls.
  
  
  CONCLUSIONS
  In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.
authors.affiliation: Research Center of Oncology, Federal University of Pará, Belém, Brazil. fernandesmr@yahoo.com.br.
authors.forename: Marianne Rodrigues
authors.initials: MR
authors.lastname: Fernandes
authors.forename: Darlen Cardoso
authors.initials: DC
authors.lastname: de Carvalho
authors.forename: Ândrea Kelly Campos Ribeiro
authors.initials: ÂK
authors.lastname: dos Santos
authors.forename: Sidney Emanuel Batista
authors.initials: SE
authors.lastname: dos Santos
authors.forename: Paulo Pimentel
authors.initials: PP
authors.lastname: de Assumpção
authors.forename: Rommel Mario Rodriguez
authors.initials: RM
authors.lastname: Burbano
authors.forename: Ney Pereira Carneiro
authors.initials: NP
authors.lastname: dos Santos
mesh_terms: D000107:Acetylation; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001938:Brazil; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics; D015331:Cohort Studies; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000235:genetics
chemical_list: D017931:DNA Primers; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human
keywords: IAM; NAT2; SNP; breast cancer; cancer susceptibility; gastric cancer