title: PEGylated fullerene/iron oxide nanocomposites for photodynamic therapy, targeted drug delivery and MR imaging.
abstract: Recently, fullerene and fullerene derivatives owning to their highly enriched physical and chemical properties have been widely explored for applications in many different fields including biomedicine. In this study, iron oxide nanoparticles (IONPs) were decorated onto the surface of fullerene (C60), and then PEGylation was performed to improve the solubility and biocompatibility of C60-IONP, obtaining a multi-functional C60-IONP-PEG nanocomposite with strong superparamagnetism and powerful photodynamic therapy capacity. Hematoporphyrin monomethyl ether (HMME), a new photodynamic anti-cancer drug, was conjugated to C60-IONP-PEG, forming a C60-IONP-PEG/HMME drug delivery system, which demonstrated an excellent magnetic targeting ability in cancer therapy. Compared with free HMME, remarkably enhanced photodynamic cancer cell killing effect using C60-IONP-PEG/HMME was realized not only in a cultured B16-F10 cells in vitro but also in an in vivo murine tumor model due to 23-fold higher HMME uptake of tumor and strong photodynamic activity of C60-IONP-PEG. Moreover, C60-IONP-PEG could be further used as a T2-contrast agent for in vivo magnetic resonance imaging. Our work showed C60-IONP-PEG/HMME had a great potential for cancer theranostic applications.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Rou
authors.initials: R
authors.lastname: Ma
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use*; D037741:Fullerenes / Q000737:chemistry / Q000627:therapeutic use*; D006415:Hematoporphyrins / Q000008:administration & dosage / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D037741:Fullerenes; D006415:Hematoporphyrins; C494379:hematoporphyrin monomethyl ether; C000499:ferric oxide; D011092:Polyethylene Glycols
keywords: Bioimaging; Fullerene; Iron oxide; Magnetic targeting; Photodynamic therapy