title: Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis.
abstract: OBJECTIVE
  Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies.
  
  
  METHODS
  In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis.
  
  
  RESULTS
  Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d.
  
  
  CONCLUSIONS
  We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
authors.affiliation: Dialysis Vascular Access Research Group, Division of Nephrology, University of Cincinnati, Cincinnati, OH - USA and Cincinnati VA Medical Center, Cincinnati, OH - USA.
authors.forename: Prabir
authors.initials: P
authors.lastname: Roy-Chaudhury
authors.forename: Rao
authors.initials: R
authors.lastname: Khan
authors.forename: Begoña
authors.initials: B
authors.lastname: Campos
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Michelle
authors.initials: M
authors.lastname: Kurian
authors.forename: Timmy
authors.initials: T
authors.lastname: Lee
authors.forename: Lois
authors.initials: L
authors.lastname: Arend
authors.forename: Rino
authors.initials: R
authors.lastname: Munda
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D003251:Constriction, Pathologic; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery*; D005268:Femoral Vein / Q000473:pathology / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000473:pathology; D008264:Macrophages / Q000473:pathology*; D013552:Swine; D013997:Time Factors