title: Radiolabelled probes targeting tumor hypoxia for personalized medicine.
abstract: Hypoxia is a characteristic feature of many solid tumors which has been described in a wide range of tumor types. Its presence impairs the effectiveness of common anti-cancer therapies and accordingly, tumor hypoxia has been associated with an aggressive tumor phenotype, poor response to radio- and chemotherapy, and worse prognosis. In order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments, in vivo measurement of tumor hypoxia is required. Given the difficulties associated with invasive methods, a non-invasive method is of major clinical interest. Although several candidate molecules have been labeled with PET and SPECT labels, none of them is used in daily clinical routine due to a number of difficulties that complicate their use. This review aims to give an overview of the most important hypoxia tracers, their prognostic significance and how these tracers can play a role in tomorrows personalized medicine.
authors.forename: Gilles
authors.initials: G
authors.lastname: Mees
authors.forename: Mike
authors.initials: M
authors.lastname: Sathekge
authors.forename: Alex
authors.initials: A
authors.lastname: Maes
authors.affiliation: University Hospital Ghent, Department of Nuclear Medicine, De Pintelaan 185, 9000-B Ghent, Belgium. christophe.vandewiele@ugent.be.
authors.forename: Christophe
authors.initials: C
authors.lastname: Van de Wiele
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis* / Q000188:drug therapy; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography / Q000379:methods / Q000639:trends; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000639:trends
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D019275:Radiopharmaceuticals