title: Investigation of metrics to assess vascular flow modifications for diverter device designs using hydrodynamics and angiographic studies.
abstract: Intracranial aneurysm treatment with flow diverters (FD) is a new minimally invasive approach, recently approved for use in human patients. Attempts to correlate the flow reduction observed in angiograms with a parameter related to the FD structure have not been totally successful. To find the proper parameter, we investigated four porous-media flow models. The models describing the relation between the pressure drop and flow velocity that are investigated include the capillary theory linear model (CTLM), the drag force linear model (DFLM), the simple quadratic model (SQM) and the modified quadratic model (MQM). Proportionality parameters are referred to as permeability for the linear models and resistance for the quadratic ones. A two stage experiment was performed. First, we verified flow model validity by placing six different stainless-steel meshes, resembling FD structures, in known flow conditions. The best flow model was used for the second stage, where six different FD's were inserted in aneurysm phantoms and flow modification was estimated using angiographically derived time density curves (TDC). Finally, TDC peak variation was compared with the FD parameter. Model validity experiments indicated errors of: 70% for the linear models, 26% for the SQM and 7% for the MQM. The resistance calculated according to the MQM model correlated well with the contrast flow reduction. Results indicate that resistance calculated according to MQM is appropriate to characterize the FD and could explain the flow modification observed in angiograms.
authors.affiliation: State University of New York at Buffalo, Toshiba Stroke Research Center, 3435 Main St., Buffalo, NY 14214, USA.
authors.forename: Ciprian N
authors.initials: CN
authors.lastname: Ionita
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Bednarek
authors.forename: Stephen
authors.initials: S
authors.lastname: Rudin
keywords: aneurysms; digital subtraction angiography; flow diverter; flow resistance; permeability
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