title: Genetic variations in CTLA-4, TNF-α, and LTA and susceptibility to T-cell lymphoma in a Chinese population.
abstract: OBJECTIVE
  T-cell lymphoma is a highly aggressive malignant lymphoma that is rare in Caucasians but relatively common in Asian populations. Factors regulating T-cell proliferation and function may play an important role in the pathogenesis of T-cell lymphoma.
  
  
  METHODS
  A total of 8 single nucleotide polymorphisms in cytotoxic T lymphocyte antigen-4 (CTLA-4), tumor necrosis factor-α (TNF-α), and lymphotoxin-α (LTA) genes were detected by polymerase chain reaction-ligation detection reaction analysis in a Chinese population of 291 patients with T-cell lymphoma and 300 healthy controls. Logistic regression was used to determine the odds ratios (ORs) and 95% confidence intervals for the associations of genotypes and haplotypes with T-cell lymphoma risk.
  
  
  RESULTS
  Among these polymorphisms, the LTA +252AA genotype was significantly associated with T-cell lymphoma risk (OR, 2.3; P=0.002). Furthermore, the TNF-α/LTA haplotype C-G-G-A (TNF-α -857C, -308G, and -238G and LTA +252A) showed a significantly increased risk for T-cell lymphoma (OR, 1.6; P=0.001).
  
  
  CONCLUSIONS
  Our study suggested that the LTA +252G>A polymorphism may influence susceptibility to T-cell lymphoma in the Chinese population.
authors.affiliation: Medical College, Shandong University, Jinan, China; Department of Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Bao
authors.initials: B
authors.lastname: Song
authors.forename: Ti
authors.initials: T
authors.lastname: Wang
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Hao
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D060908:CTLA-4 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha
keywords: CTLA-4; Genetic susceptibility; Immunogenetics; LTA; T-cell lymphoma; TNF-α