title: Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats.
abstract: In the present study, we evaluated the effects of gallic acid (GA; 30 mg/kg, orally, once daily for 26 days starting from day 5 prior to streptozotocin injection) on cognitive impairment and cerebral oxidative stress induced by intracerebroventricular-streptozotocin (ICV-STZ; bilaterally, two doses of 3 mg/kg) injection as an animal model of sporadic Alzheimers type (SDAT) in rats. The results showed that ICV-STZ-injection reduced the passive avoidance and spatial memory performance associated with decreased non-enzymatic [total thiol concentration, -58.5%, -50.7%] and enzymatic [superoxide dismutase (SOD, -30.2%, -32.9%), catalase (CAT, -43.5%, -50.7%), glutathione peroxidase (GPx, -57.1%, -61.7%)] activities and increased the level of thio-barbituric acid reactive species (TBARS, +103.5%, +82.5%) in the hippocampus and cerebral cortex, respectively. In contrast, chronic administration of GA significantly prevented cognitive deficits and biochemical alterations in the ICV-STZ rats. These findings highlight the beneficial role of GA in the ICV-STZ rats via enhancement of cerebral antioxidant defense system. Thus, it may have a therapeutic value for the treatment of SDAT.
authors.affiliation: Department of Pharmacology, School of Medicine, Physiology and Atherosclerosis Research Centers, Ahvaz Jundishapur Univ. of Med. Sciences (AJUMS), Ahvaz, Iran. Electronic address: mansouri_smt@yahoo.com.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Mansouri
authors.forename: Bahareh
authors.initials: B
authors.lastname: Naghizadeh
authors.forename: Behnam
authors.initials: B
authors.lastname: Ghorbanzadeh
authors.forename: Yaghoub
authors.initials: Y
authors.lastname: Farbood
authors.forename: Alireza
authors.initials: A
authors.lastname: Sarkaki
authors.forename: Kowsar
authors.initials: K
authors.lastname: Bavarsad
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D005707:Gallic Acid / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning; D008568:Memory / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage*
chemical_list: D013311:Streptozocin; D005707:Gallic Acid
keywords: Gallic acid; ICV-STZ; Oxidative stress; Passive avoidance memory; Rat; Spatial memory