title: Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery.
abstract: OBJECTIVE
  To study the effectiveness and safety of acellular dermal matrix (ADM) graft in preventing Frey syndrome after parotid neoplasm surgery, we reviewed foreign reported clinical randomized controlled trials systematically. Based on this review, we aimed to assess the effectiveness of ADM graft and provide reliable evidence for clinical application.
  
  
  METHODS
  We reviewed foreign-language databases, such as MEDLINE, applied meta-analysis with Rev.Man 5, and drew forest plots with odds ratio as effect size.
  
  
  RESULTS
  Three trials were recruited. The morbidity of Frey syndrome in experimental group was significantly lower than that in control on both subjective index and objective index, with odds ratios at 0.03 (95% confidence interval, 0.01-0.11) and 0.03 (95% confidence interval, 0.01-0.12), respectively. There was no significant difference between ADM group and blank control in total adverse reactions and complication incidence, whereas results differed for a kind of specific adverse reaction or complication.
  
  
  CONCLUSIONS
  Based on existing research data, implanting ADM could effectively prevent Frey syndrome, and its poor prognosis effects did not significantly increase, which suggested that its total safety was reliable. Nevertheless, further investigations about the difference on a specific adverse reaction or complication were still needed.
authors.affiliation: From the *Department of Head and Neck Surgery; †Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu; ‡State Key Laboratory of Oral Diseases in Sichuan University, Sichuan; and §Department of Oral and Maxillary Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jin-chuan
authors.initials: JC
authors.lastname: Fan
authors.forename: Chang-jin
authors.initials: CJ
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Zhao
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Mi
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.forename: Ji-feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Gui-quan
authors.initials: GQ
authors.lastname: Zhu
authors.forename: Chao
authors.initials: C
authors.lastname: Li
mesh_terms: D062088:Acellular Dermis; D006801:Humans; D010307:Parotid Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D016038:Skin Transplantation / Q000379:methods*; D013547:Sweating, Gustatory / Q000517:prevention & control*; D016896:Treatment Outcome