title: [Clinical features and comorbidities of Asperger syndrome in children].
abstract: OBJECTIVE
  To investigate and summarize the clinical features and comorbidities of Asperger syndrome (AS) in children and to provide a theoretical basis for improving the understanding and diagnosis of AS.
  
  
  METHODS
  Inquiry of medical history, physical examination, behavioral observation, psychiatric examination, questionnaire survey, and the Wechsler Intelligence Scale were used to summarize and analyse the clinical data of 95 children with AS, including chief complaint, symptoms, perinatal and familial conditions, family genetic history, and common comorbidities.
  
  
  RESULTS
  AS was more common in male children, with hyperactivity, inattention, and social withdrawal as frequent chief complaints. The main clinical manifestations included poor communication skills (95%), restricted interest (82%), repetitive and stereotyped patterns of behavior (77%), semantic comprehension deficit (74%), and indiscipline (68%). Verbal IQ was higher than performance IQ in most patients. The comorbidities of AS included attention deficit hyperactivity disorder (ADHD) (39%), emotional disorder (18%), and schizophrenia (2%); emotional disorder was more common in patients aged 13-16 years, while ADHD was more common in patients aged 7-16 years. Among these patients, 61% had fathers with introverted personality, 43% had mothers with introverted personality, and 19% had a family history of mental illness.
  
  
  CONCLUSIONS
  AS has specific clinical manifestations. It is essential to know more about the clinical features and comorbidities of AS, which is helpful for early identification and diagnosis of AS.
authors.affiliation: Department of Pediatrics, Tongji Hospital of Tongji University, Shanghai 200065, China. xtxie@163.com.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Fu
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Xie
authors.forename: Zhu
authors.initials: Z
authors.lastname: Mei
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D020817:Asperger Syndrome / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male