title: Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents: association with metabolic risk profile.
abstract: OBJECTIVE
  To investigate the relationship between liver fat and in vivo insulin sensitivity, body composition, abdominal adiposity, and lipid metabolism in obese adolescent girls with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Cross-sectional case-control study.
  
  
  METHODS
  Research center.
  
  
  METHODS
  Thirty Tanner stage V obese girls with PCOS.
  
  
  METHODS
  None.
  
  
  METHODS
  Liver fat, abdominal adiposity, in vivo insulin-stimulated glucose disposal, whole-body lipolysis, fat oxidation, lipoprotein particle size and concentration, and liver enzymes (alanine aminotransferase and aspartate aminotransferase). Fatty liver index <1 is indicative of fatty liver.
  
  
  RESULTS
  Fatty liver was present in 6.7% of the individuals (6.7%). Levels of alanine aminotransferase and aspartate aminotransferase were not different between those with fatty liver vs. without. Fatty liver index was associated with age (r = -0.53), body mass index (r = -0.41), total (r = -0.43) and subcutaneous (r = -0.41) abdominal adiposity, insulin-stimulated glucose disposal (r = 0.36), and small, medium small, and very small low-density lipoprotein concentrations (r ≥ -0.43). In a multiple regression analysis, age, total T, race, and insulin-stimulated glucose disposal explained 43% of the variance (R(2) = 0.43) in fatty liver index, with age (R(2) = 0.28) and total T (R(2) = 0.11) being independent contributors.
  
  
  CONCLUSIONS
  Liver fat is associated with increasing age, even in the narrow adolescent age range, increasing abdominal adiposity, worsening insulin sensitivity, and dyslipoproteinemia in obese adolescent girls with PCOS. Targeting these abnormalities early in the course of PCOS may halt future nonalcoholic fatty liver disease in adulthood.
authors.affiliation: Division of Weight Management, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Sara F
authors.initials: SF
authors.lastname: Michaliszyn
authors.forename: Sojung
authors.initials: S
authors.lastname: Lee
authors.forename: Hala
authors.initials: H
authors.lastname: Tfayli
authors.forename: Silva
authors.initials: S
authors.lastname: Arslanian
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D050154:Adiposity; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease; D063766:Pediatric Obesity / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Polycystic ovary syndrome; hepatic steatosis; obesity
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