title: Meta-analyses of 8 polymorphisms associated with the risk of the Alzheimer's disease.
abstract: OBJECTIVE
  The aim of this study was to evaluate the combined contribution of 8 polymorphisms to the risk of Alzheimer's disease (AD).
  
  
  METHODS
  Through a comprehensive literature search for genetic variants involved in the AD association study, we harvested a total of 6 genes (8 polymorphisms) for the current meta-analyses. These genes consisted of A2M (5bp I/D and V1000I), ABCA2 (rs908832), CHAT (1882G >A, 2384G >A), COMT (Val158Met), HTR6 (267C >T) and LPL (Ser447Ter).
  
  
  RESULTS
  A total of 33 studies among 9,453 cases and 10,833 controls were retrieved for the meta-analyses of 8 genetic variants. It was showed that A2M V1000I (odd ratio (OR) = 1.26, 95% confidence interval (CI) = 1.07-1.49, P = 0.007), rs908832 allele of ABCA2 (OR = 1.55, 95% CI = 1.12-2.16, P = 0.009), 2384G >A of CHAT (OR = 1.22, 95% CI = 1.00-1.49, P = 0.05) and Ser447Ter of LPL in the Northern-American population (OR = 0.56, 95% CI = 0.35-0.91, P = 0.02) were significantly associated with the risk of AD. No association was found between the rest of the 5 polymorphisms and the risk of AD.
  
  
  CONCLUSIONS
  Our results showed that A2M V1000I polymorphism in German, Korean, Chinese, Spanish, Italian and Polish populations, rs90883 of ABCA2 gene in French, American, Swiss, Greek and Japanese populations, 2384G >A of CHAT gene in British and Korean populations and LPL Ser447Ter in the Northern-American population were associated with the risk of AD.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
authors.forename: Xuting
authors.initials: X
authors.lastname: Xu
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Wang
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liao
authors.forename: Lan
authors.initials: L
authors.lastname: Chang
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Limin
authors.initials: L
authors.lastname: Xu
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Shen
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Qinwen
authors.initials: Q
authors.lastname: Wang
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D019943:Amino Acid Substitution; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk
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