title: Regulation of gastric motility and blood flow during acute nociceptive stimulation of the paraspinal muscles in urethane-anaesthetised rats.
abstract: The aim of this study was to examine gastric motility and blood flow during nociceptive hypertonic saline injections (HS) in paraspinal muscles of urethane-anaesthetised rats. Gastric pressure was not affected by HS in intact or vagotomised conditions. After cervical spinalisation, it was decreased by injections at T13 or L6 but not T2. Moreover, HS injections at T13 produced greater gastric pressure decreases compared with L6 and T2 and increased gastric sympathetic nerve activity. Blood pressure and gastric blood flow were decreased by T13 injections in spinal cord intact but not spinalised rats. Besides, isotonic saline injections (non-nociceptive) produced non-significant or marginal effects. These results indicate that gastric motility is decreased by nociceptive input from paraspinal muscles in spinalised rats through activation of the gastric sympathetic nerve. Although gastric blood flow was also decreased by nociceptive stimulation at T13 in spinal cord intact rats, these changes seem to depend on blood pressure.
authors.affiliation: Department of Chiropractic, Université du Québec à Trois-Rivières, Trois-Rivières, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Piché
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Watanabe
authors.forename: Harumi
authors.initials: H
authors.lastname: Hotta
mesh_terms: D018686:Anesthetics, Intravenous / Q000009:adverse effects; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000098:blood supply*; D007267:Injections; D008159:Lumbar Vertebrae / Q000294:innervation; D008297:Male; D023421:Models, Animal; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D064170:Paraspinal Muscles / Q000187:drug effects / Q000294:innervation* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000502:physiology*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology; D013904:Thoracic Vertebrae / Q000294:innervation; D014474:Unconsciousness / Q000139:chemically induced; D014520:Urethane / Q000009:adverse effects
chemical_list: D018686:Anesthetics, Intravenous; D012462:Saline Solution, Hypertonic; D014520:Urethane
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