title: Tissue clearing for optical anatomy.
abstract: Quest for transparency: Detailed optical imaging of complex biological entities remains an unmet goal mainly because of the light scattering of biological tissue. A new approach to tissue clearing termed CLARITY is getting us closer to an anatomical view of thick tissues and entire organs with cellular resolution.
authors.affiliation: Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany).
authors.forename: Dmytro A
authors.initials: DA
authors.lastname: Yushchenko
authors.forename: Carsten
authors.initials: C
authors.lastname: Schultz
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008027:Light; D008279:Magnetic Resonance Imaging; D051379:Mice; D008853:Microscopy; D061848:Optical Imaging; D012542:Scattering, Radiation; D014021:Tissue Preservation / Q000379:methods*
keywords: fluorescence imaging; light scattering; microscopy; tissue clearing