title: Carrying yourself: self antigen composition of the lymphatic fluid.
abstract: Advances in proteomics methodology and instrumentation have allowed detailed characterization of the composition of lymph. Far from being a simple ultrafiltrate of blood plasma, lymph has been shown to carry a rich repertoire of proteins and peptides reflecting the tissue of origin and its physiological state. Peptides derived from lymph can be loaded on the MHCII proteins, particularly those present on immature and/or inactivated antigen presenting cells, and may play an important role in maintenance of peripheral tolerance.
authors.affiliation: 1 Department of Pathology, Microbiology and Immunology, Albert Einstein College of Medicine , New York, New York.
authors.forename: Laura
authors.initials: L
authors.lastname: Santambrogio
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Stern
mesh_terms: D001324:Autoantigens / Q000276:immunology / Q000378:metabolism*; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism; D019276:Glycocalyx / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008196:Lymph / Q000276:immunology / Q000378:metabolism*; D008954:Models, Biological; D010455:Peptides / Q000276:immunology / Q000378:metabolism*; D011506:Proteins / Q000276:immunology / Q000378:metabolism*; D040901:Proteomics / Q000379:methods
chemical_list: D001324:Autoantigens; D010455:Peptides; D011506:Proteins
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