title: Epithelial-mesenchymal transition phenotype is associated with patient survival in small intestinal adenocarcinoma.
abstract: We investigated the clinical significance of epithelial-mesenchymal transition (EMT) phenotype in 184 small intestinal adenocarcinomas (SIACs) based on the expression pattern of EMT-related proteins in cancer cells.
  
  
  
  Immunohistochemistry for epithelial (E-cadherin) and mesenchymal (vimentin and fibronectin) markers were performed and cases of SIAC were classified into four subtypes of EMT: complete type (E-cadherin-, vimentin+ and/or fibronectin+), wild type (E-cadherin+, vimentin-, fibronectin-), incomplete 1 type (hybrid type; E-cadherin+, vimentin+ and/or fibronectin+), and incomplete 2 type (null type; E-cadherin-, vimentin-, fibronectin-).
  
  
  
  We identified 19 (10.3%) cases of complete EMT type, 86 (46.7%) cases of wild type and 79 (43%) cases of incomplete EMT type [hybrid type, 22 (12%) cases; null type, 57 (31%) cases]. Complete EMT phenotype showed a significant association with undifferentiated histology (p<0.001). Overall survival of SIAC patients with complete EMT phenotype was significantly shorter than those of patients with incomplete (p=0.001) and wild (p<0.001) types. In multivariate analysis, complete EMT phenotype was an independent prognostic factor in SIAC patients (hazard ratio 2.3; 95% confidence interval 1.15-4.6; p=0.019).
  
  
  
  Complete EMT phenotype stratifies a specific group representing a poor clinical outcome in patients with SIAC.
authors.affiliation: *Departments of Pathology, Yeungnam University College of Medicine, Daegu †Chonbuk National University Medical School, Jeonju ‡Inje University Sanggye Paik Hospital, Seoul §Kyungpook National University School of Medicine, Daegu ||Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea ¶currently Department of Pathology, Daegu Fatima Hospital, Daegu, South Korea.
authors.forename: Aeri
authors.initials: A
authors.lastname: Kim
authors.forename: Young Kyung
authors.initials: YK
authors.lastname: Bae
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Gu
authors.forename: Jung Yoen
authors.initials: JY
authors.lastname: Kim
authors.forename: Kyu Yun
authors.initials: KY
authors.lastname: Jang
authors.forename: Han-Ik
authors.initials: HI
authors.lastname: Bae
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seung-Mo
authors.initials: SM
authors.lastname: Hong
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D018572:Disease-Free Survival; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000401:mortality* / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor