title: [Cardiac sympathetic innervation imaging with myocardial MIBG scintigraphy].
abstract: Metaiodobenzylguanidine (MIBG) was developed initially as a tracer for oncological imaging; when labeled with 123 I or 131 I, it may detect APUDomas, such as pheochromocytomas and paragangliomas. In the last years, MIBG has found an important role also in neurology and cardiology, as cardiac innervation tracer. Actually, MIBG cardiac imaging is a universally accepted method to estimate cardiac sympathetic innervations. This review covers the role of MIBG cardiac imaging in Parkinson disease and parkinsonisms, from the pathophysiological premises for cardiac denervation to new emerging data.
authors.forename: Eugenio Annibale
authors.initials: EA
authors.lastname: Genovese
authors.forename: Vania
authors.initials: V
authors.lastname: Mallardo
authors.forename: Stefania
authors.initials: S
authors.lastname: Cipullo
authors.forename: Antonino
authors.initials: A
authors.lastname: Restuccia
authors.forename: Domenico
authors.initials: D
authors.lastname: Galea
authors.forename: Gianfranco
authors.initials: G
authors.lastname: D'Agosto
authors.forename: Imma
authors.initials: I
authors.lastname: Di Lanno
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cappabianca
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D003937:Diagnosis, Differential; D006321:Heart / Q000294:innervation*; D006329:Heart Conduction System / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020961:Lewy Body Disease / Q000175:diagnosis; D019578:Multiple System Atrophy / Q000175:diagnosis; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017729:Presynaptic Terminals / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis; D013562:Sympathectomy; D017779:Sympathetic Fibers, Postganglionic / Q000000981:diagnostic imaging*; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine