title: SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease.
abstract: SIRT3 is a NAD(+)-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an instrumental regulator of the mitochondrial adaptive responses to stress, including metabolic reprogramming and enhancing antioxidant defense mechanisms. Here, we discuss the role that SIRT3 plays at both a cellular and physiological level and consider its involvement in disease. Mitochondrial dysfunction is a key contributing factor in many diseases; however, the mechanisms involved are often not well understood, and few targeted therapies exist. If manipulation of SIRT3 proves to be beneficial in disease states, then it could be a promising target for novel therapies.
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, UK.
authors.forename: Heather J M
authors.initials: HJ
authors.lastname: Weir
authors.forename: Jon D
authors.initials: JD
authors.lastname: Lane
authors.forename: Nina
authors.initials: N
authors.lastname: Balthasar
keywords: cell protection; mitochondria; sirtuins; stress
references.citation: Proteomics. 2009 May;9(9):2444-56
references.pmid: 19343720
references.citation: J Biol Chem. 2005 Apr 22;280(16):16456-60
references.pmid: 15716268
references.citation: Sci Rep. 2012;2:425
references.pmid: 22645641
references.citation: Cell Metab. 2010 Dec 1;12(6):654-61
references.pmid: 21109197
references.citation: Oncogene. 2011 Jun 30;30(26):2986-96
references.pmid: 21358671
references.citation: Int J Biol Sci. 2008 Sep 05;4(5):291-9
references.pmid: 18781224
references.citation: Cancer Cell. 2010 Jan 19;17(1):41-52
references.pmid: 20129246
references.citation: Genes Dev. 2006 Nov 1;20(21):2913-21
references.pmid: 17079682
references.citation: Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14608-13
references.pmid: 21873205
references.citation: Cell Metab. 2012 Jun 6;15(6):838-47
references.pmid: 22682224
references.citation: J Biol Chem. 2009 May 15;284(20):13291-5
references.pmid: 19182219
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52
references.pmid: 18794531
references.citation: J Cell Sci. 2010 Mar 15;123(Pt 6):894-902
references.pmid: 20159966
references.citation: Cell. 1995 Feb 10;80(3):485-96
references.pmid: 7859289
references.citation: Trends Pharmacol Sci. 2012 Apr;33(4):207-14
references.pmid: 22398146
references.citation: Nature. 2012 Feb 22;483(7388):218-21
references.pmid: 22367546
references.citation: Biochem J. 2008 Apr 15;411(2):279-85
references.pmid: 18215119
references.citation: Nature. 2010 Mar 4;464(7285):121-5
references.pmid: 20203611
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10230-10235
references.pmid: 16790548
references.citation: Biochem J. 2008 Apr 15;411(2):e11-3
references.pmid: 18363549
references.citation: PLoS One. 2010 Jul 22;5(7):e11707
references.pmid: 20661474
references.citation: Genomics. 2005 Feb;85(2):258-63
references.pmid: 15676284
references.citation: PLoS One. 2011 Mar 01;6(3):e14731
references.pmid: 21390294
references.citation: Cancer Cell. 2011 Mar 8;19(3):416-28
references.pmid: 21397863
references.citation: PLoS One. 2012;7(11):e48225
references.pmid: 23139766
references.citation: J Biol Chem. 2010 Mar 5;285(10):7417-29
references.pmid: 20042612
references.citation: Mol Cell. 2011 Jan 21;41(2):139-49
references.pmid: 21255725
references.citation: Cell. 2010 Nov 24;143(5):802-12
references.pmid: 21094524
references.citation: Mol Cell Biol. 2008 Oct;28(20):6384-401
references.pmid: 18710944
references.citation: Cell Metab. 2010 Dec 1;12(6):662-7
references.pmid: 21109198
references.citation: J Biol Chem. 2005 Apr 8;280(14):13560-7
references.pmid: 15653680
references.citation: Nature. 2006 Oct 19;443(7113):787-95
references.pmid: 17051205
references.citation: Nature. 2011 Sep 21;477(7365):482-5
references.pmid: 21938067
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10224-10229
references.pmid: 16788062
references.citation: Nature. 2005 Mar 3;434(7029):113-8
references.pmid: 15744310
references.citation: Aging (Albany NY). 2009 Aug 15;1(9):771-83
references.pmid: 20157566
references.citation: J Mol Biol. 2008 Oct 10;382(3):790-801
references.pmid: 18680753
references.citation: Mol Cell. 2011 Oct 21;44(2):177-90
references.pmid: 21856199
references.citation: Genes Dev. 2008 Jul 1;22(13):1753-7
references.pmid: 18550784
references.citation: Aging (Albany NY). 2010 Dec;2(12):914-23
references.pmid: 21212461
references.citation: Biochemistry. 2010 Jan 19;49(2):304-11
references.pmid: 20000467
references.citation: Neurobiol Dis. 2013 Mar;51:72-81
references.pmid: 22819776
references.citation: J Clin Invest. 2009 Sep;119(9):2758-71
references.pmid: 19652361
references.citation: Mol Cell. 2013 Jan 10;49(1):186-99
references.pmid: 23201123
references.citation: Mol Cell Biol. 2007 Dec;27(24):8807-14
references.pmid: 17923681
references.citation: PLoS One. 2007 Aug 01;2(8):e690
references.pmid: 17668068
references.citation: Mol Cell. 2010 Dec 22;40(6):893-904
references.pmid: 21172655
references.citation: J Nutr Biochem. 2012 Oct;23(10):1201-6
references.pmid: 22819548