title: The costamere bridges sarcomeres to the sarcolemma in striated muscle.
abstract: Costameres are sub-membranous, Z-line associated structures found in striated muscle. They have been shown to have important roles in transmission of force from the sarcomere to the sarcolemma and extracellular matrix, maintaining mechanical integrity of the sarcolemma, and orchestrating mechanically related signaling. The costamere is akin to the more well-known focal adhesion complex present in most cells. The Z-line is a critical structural anchor for the sarcomere, but it is also a hot-spot for muscle cell signaling. Therefore functionally, the costamere represents a two-way signaling highway tethered between the Z-line and the extracellular matrix, relaying mechanical stress signals from outside the cell to intracellular signaling networks. In this role it can modulate myofibril growth and contraction. The major force generated by sarcomeres is transduced in the lateral direction from the sarcomere to the extracellular matrix through the costamere. Two major protein complexes have been described at the costamere: the dystrophin-glycoprotein complex and the integrin-vinculin-talin complex. The importance of these two protein complexes in striated muscle function has between demonstrated both in human disease and mouse models. Members of the dystrophin glycoprotein complex and integrins have both been reported to interact directly with filamin-C, thus linking costameric complexes with those present at the Z-line. Moreover, studies from our labs and others have shown that the Z-line proteins belonging to the PDZ-LIM domain protein family, enigma homolog (ENH) and cypher, may directly or indirectly be involved in this linkage. The following review will focus on the protein components of this linkage, their function in force transmission, and how the dysfunction or loss of proteins within these complexes contributes to muscular disease.
authors.affiliation: Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, California, 92093, USA.
authors.forename: Angela K
authors.initials: AK
authors.lastname: Peter
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Cheng
authors.forename: Robert S
authors.initials: RS
authors.lastname: Ross
authors.forename: Kirk U
authors.initials: KU
authors.lastname: Knowlton
authors.forename: Ju
authors.initials: J
authors.lastname: Chen
keywords: Costamere; Cypher/ZASP; Integrin; Mechanotransduction; Vinculin; Z-line
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