title: Clinical outcomes of allogeneic stem cell transplantation for relapsed or refractory follicular lymphoma: a retrospective analysis by the Fukuoka Blood and Marrow Transplantation Group.
abstract: Allogeneic hematopoietic stem cell transplantation (allo-SCT) is considered the only curative treatment for relapsed or refractory follicular lymphoma (FL), but it has a high treatment-related mortality rate. Only a few reports, however, have described the efficacy of allo-SCT for FL in the Japanese population. We retrospectively analyzed the outcome of allo-SCT in 30 patients with FL. Seventeen (56.7 %) patients were chemorefractory, whereas 13 (43.3 %) were chemosensitive. An estimated 2-year overall survival rate (OS) and relapse rate of all patients was 46.7 and 20.0 %, respectively. There were no significant differences in the estimated 2-year OS rate between patients who received myeloablative conditioning and those who received reduced-intensity conditioning (P = 0.98), and among the recipients of related bone marrow (BM)/peripheral blood stem cell, unrelated BM and umbilical cord blood (P = 0.20). In patients who were either chemosensitive or chemorefractory at allo-SCT, the 2-year OS rate was 69.2 and 29.4 % (P = 0.06). Patients with mild-to-moderate acute GVHD had better 2-year PFS rate compared with patients who had severe acute GVHD (P = 0.01), but not better PFS compared with patients who had no acute GVHD (P = 0.12). Our results suggest that the graft-versus-lymphoma effects of allo-SCT may provide survival benefits even in patients with chemorefractory FL.
authors.affiliation: Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Ito
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kamimura
authors.forename: Ken
authors.initials: K
authors.lastname: Takase
authors.forename: Hideho
authors.initials: H
authors.lastname: Henzan
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugio
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Yuju
authors.initials: Y
authors.lastname: Ohno
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Eto
authors.forename: Takanori
authors.initials: T
authors.lastname: Teshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008224:Lymphoma, Follicular / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome
references.citation: Biol Blood Marrow Transplant. 2008 Apr;14(4):418-25
references.pmid: 18342784
references.citation: Haematologica. 2007 May;92(5):627-34
references.pmid: 17488686
references.citation: Blood. 2002 Nov 1;100(9):3108-14
references.pmid: 12384406
references.citation: J Clin Oncol. 1983 Nov;1(11):710-9
references.pmid: 6668489
references.citation: Biol Blood Marrow Transplant. 2008 Feb;14(2):236-45
references.pmid: 18215784
references.citation: J Clin Oncol. 2008 Jan 10;26(2):211-7
references.pmid: 18056679
references.citation: J Clin Oncol. 2007 Feb 10;25(5):579-86
references.pmid: 17242396
references.citation: J Clin Oncol. 2010 Aug 10;28(23):3695-700
references.pmid: 20606089
references.citation: Am J Hematol. 2012 Sep;87(9):929-31
references.pmid: 22674621
references.citation: Haematologica. 2010 Jul;95(7):1176-82
references.pmid: 20107156
references.citation: Transplantation. 1974 Oct;18(4):295-304
references.pmid: 4153799
references.citation: Blood. 2001 Dec 15;98(13):3595-9
references.pmid: 11739162
references.citation: Haematologica. 2003 Jul;88(7):811-23
references.pmid: 12857561
references.citation: Int J Hematol. 2012 Jul;96(1):10-25
references.pmid: 22592321
references.citation: N Engl J Med. 1993 Mar 4;328(9):593-602
references.pmid: 8429851
references.citation: Am J Hematol. 2012 Aug;87(8):770-5
references.pmid: 22641292
references.citation: Blood. 2012 Mar 1;119(9):2141-8
references.pmid: 22234682
references.citation: J Clin Oncol. 1986 Oct;4(10):1470-80
references.pmid: 3531422
references.citation: Bone Marrow Transplant. 2012 Oct;47(10):1318-20
references.pmid: 22327132
references.citation: Biol Blood Marrow Transplant. 2011 Jul;17(7):1051-7
references.pmid: 21073974
references.citation: Biol Blood Marrow Transplant. 2011 Sep;17(9):1395-403
references.pmid: 21296675
references.citation: Bone Marrow Transplant. 2005 Aug;36(3):205-13
references.pmid: 15937505
references.citation: Stat Med. 1999 Mar 30;18(6):695-706
references.pmid: 10204198
references.citation: Int J Hematol. 2010 Jul;92(1):5-11
references.pmid: 20574673
references.citation: Bone Marrow Transplant. 2003 Apr;31(8):667-78
references.pmid: 12692607
references.citation: Am J Med. 1980 Aug;69(2):204-17
references.pmid: 6996481
references.citation: Blood. 1998 Sep 1;92(5):1832-6
references.pmid: 9716615
references.citation: J Clin Oncol. 1995 Jan;13(1):140-7
references.pmid: 7799014
references.citation: Blood. 2012 Jun 28;119(26):6373-8
references.pmid: 22586182
references.citation: Int J Hematol. 2012 Nov;96(5):544-51
references.pmid: 23108535
references.citation: Leukemia. 2011 Mar;25(3):551-5
references.pmid: 21183951
references.citation: Br J Haematol. 2009 Dec;147(5):719-28
references.pmid: 19793383
references.citation: Transplantation. 2011 Aug 15;92(3):366-71
references.pmid: 21677598
references.citation: Int J Hematol. 2002 Dec;76(5):385-93
references.pmid: 12512832
references.citation: Blood. 1990 Feb 1;75(3):555-62
references.pmid: 2297567
references.citation: Blood. 1989 May 1;73(6):1720-8
references.pmid: 2653460
references.citation: Blood. 2003 Nov 15;102(10):3521-9
references.pmid: 12893748
references.citation: Bone Marrow Transplant. 2003 Dec;32(12):1159-63
references.pmid: 14647270