title: Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder.
abstract: Background and Aim. Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes. Methods. We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy. Results. Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis. Conclusions. This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.
authors.affiliation: Internal Medicine Department, Medica Sur Clinic and Foundation, Puente de Piedra No. 150, Colonia Toriello Guerra, Delegación Tlalpan, 14050 Mexico City, Mexico.
authors.forename: Ylse
authors.initials: Y
authors.lastname: Gutiérrez-Grobe
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Bahena-Gonzalez
authors.forename: Magali
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authors.lastname: Herrera-Gomar
authors.forename: Pedro
authors.initials: P
authors.lastname: Mendoza-Diaz
authors.forename: Sandra
authors.initials: S
authors.lastname: García-López
authors.forename: Octavio
authors.initials: O
authors.lastname: González-Chon
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