title: Pancreatic neuroendocrine tumor with ectopic adrenocorticotropin production: a case report and review of literature.
abstract: Pancreatic neuroendocrine tumors (p-NETs) entail a vast array of tumors, which can vary from benign neoplastic growths to rapidly aggressive malignancies. Such is the case with ectopic adrenocorticotropic hormone (ACTH)-producing p-NETs. These tumors have been found to be quite aggressive and a challenge to treat, especially due to the occurrence of metastatic disease even after resection of the primary tumor. We discuss the case of a 44-year-old female who initially presented with vague, non-specific symptoms, in which a malignant p-NET was found to be the cause of her clinical presentation. Although resection of the pancreatic mass was performed, the patient presented again with metastatic disease to the liver.
authors.affiliation: Department of Medicine and Cancer Center, Tufts Medical Center, 800 Washington Street Box 245, Boston, MA 02111, U.S.A. wsaif@tuftsmedicalcenter.org.
authors.forename: Forum B
authors.initials: FB
authors.lastname: Patel
authors.forename: Simon
authors.initials: S
authors.lastname: Khagi
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Daly
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lechan
authors.forename: Vorawan
authors.initials: V
authors.lastname: Ummaritchot
authors.forename: Muhammad W
authors.initials: MW
authors.lastname: Saif
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D000324:Adrenocorticotropic Hormone; D015282:Octreotide
keywords: Cushing's Syndrome; Pancreatic neuroendocrine tumor; ectopic ACTH syndrome; gastroenteropancreatic neuroendocrine tumor