title: Recreating kidney progenitors from pluripotent cells.
abstract: Access to human pluripotent cells theoretically provides a renewable source of cells that can give rise to any required cell type for use in cellular therapy or bioengineering. However, successfully directing this differentiation remains challenging for most desired endpoints cell type, including renal cells. This challenge is compounded by the difficulty in identifying the required cell type in vitro and the multitude of renal cell types required to build a kidney. Here we review our understanding of how the embryo goes about specifying the cells of the kidney and the progress to date in adapting this knowledge for the recreation of nephron progenitors and their mature derivatives from pluripotent cells.
authors.affiliation: Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
authors.forename: Minoru
authors.initials: M
authors.lastname: Takasato
authors.forename: Barbara
authors.initials: B
authors.lastname: Maier
authors.forename: Melissa H
authors.initials: MH
authors.lastname: Little
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000196:embryology*; D038081:Organogenesis / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000166:cytology*; D023822:Tissue Engineering
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