title: Blood transfusion; additional historical aspects. Part 2. The introduction of chemical anticoagulants; trials of 'Phosphate of soda'.
abstract: The pioneers of transfusion medicine around the turn of the 19th into the 20th centuries struggled with the awkward propensity of shed blood to clot. This article, a companion to a previous one (Boulton, 2013, Submitted for publication), describes in more detail how they recognised a potential for chemical anticoagulants which led to the introduction for a short period of sodium phosphate to aid blood transfusion: these cases preceded the introduction of citrate (Mollison, 2000, British Journal of Haematology, 108, 13-18).
authors.affiliation: NHS BT, Southampton, UK.
authors.forename: F E
authors.initials: FE
authors.lastname: Boulton
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000266:history* / Q000627:therapeutic use; D001803:Blood Transfusion / Q000266:history* / Q000379:methods; D002951:Citrates / Q000266:history* / Q000627:therapeutic use; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D010710:Phosphates / Q000266:history* / Q000627:therapeutic use; D000077559:Sodium Citrate
chemical_list: D000925:Anticoagulants; D002951:Citrates; D010710:Phosphates; D000077559:Sodium Citrate; C018279:sodium phosphate
keywords: chemical anticoagulants for transfusion; phosphate of soda