title: Determination of 48 fragrance allergens in toys using GC with ion trap MS/MS.
abstract: This paper presents a method for the simultaneous determination of 48 fragrance allergens in four types of toys (plastic toys, play clays, plush toys, and paper toys) based on GC with ion trap MS/MS. Compared with single-stage MS, MS/MS is superior in terms of the qualification and quantification of a large range of compounds in complicated matrices. Procedures for extraction and purification were optimized for each toy type. The method proved to be linear over a wide range of concentrations for all analytes with correlation coefficients between 0.9768 and 0.9999. Validation parameters, namely, LODs and LOQs, ranged from 0.005-5.0 and from 0.02-20 mg/kg, respectively. Average recoveries of target compounds (spiked at three concentration levels) were in the range of 79.5-109.1%. Intraday and interday repeatabilities of the proposed method varied from 0.7-10.5% and from 3.1-13.4%, respectively. The proposed method was used to monitor fragrance allergens in commercial toy products. Our findings indicate that this method is an accurate and effective technique for analyzing fragrance allergens in materials composed of complex components.
authors.affiliation: Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing, P. R. China; College of Chemistry, Beijing Institute of Technology, Beijing, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lv
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Wentao
authors.initials: W
authors.lastname: Li
authors.forename: Haiyu
authors.initials: H
authors.lastname: Li
authors.forename: Pi
authors.initials: P
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Xianshuang
authors.initials: X
authors.lastname: Meng
authors.forename: Meiling
authors.initials: M
authors.lastname: Qi
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
mesh_terms: D000485:Allergens / Q000032:analysis*; D002849:Chromatography, Gas; D010476:Perfume / Q000737:chemistry*; D010988:Play and Playthings; D053719:Tandem Mass Spectrometry
chemical_list: D000485:Allergens; D010476:Perfume
keywords: Fragrance allergens; Gas chromatography; Ion trap MS/MS; Toys