title: Clinical study on the treatment of chronic wound with negatively-charged aerosol.
abstract: BACKGROUND
  Aerosols are defined as the mixture of liquid or solid particles/droplets that are stably suspending in air. When carrying a certain amount of negative charge, they will be defined as negatively-charged aerosol. This report investigates the effect of negatively-charged aerosol on the healing of chronic wound.
  
  
  METHODS
  140 patients with chronic wound were assigned randomly into two groups. Normal, routine treatment was applied on chronic wounds of 73 patients depending on wounds situation (control group). While another 67 similar patients received negatively-charged aerosol therapy (2 hours per time, twice a day) and were used as experimental group. Wound healing assessment including the patients' complication, detection of bacteria in wound secretions, and evaluation of wound healing.
  
  
  RESULTS
  The results of our study showed that after the application of negatively-charged aerosols, and condition and infection rate of wounds from experiment group were better and lower than that of control group. In comparison with control group, the relative size of wounds from experiment group was significantly smaller (P<0.05) at post-treatment day 0, 7, 14, 21 and 28. Also, the time required for wound healing in the experimental group was significantly shorter (P<0.05) than that in the control group.
  
  
  CONCLUSIONS
  Negatively-charged aerosol therapy can accelerate wound healing speed and improve the healing of chronic wounds. Thus, we wound recommend the consideration of Negatively-charged aerosol therapies in addition to normal wound treatment in cases of chronic wound.
authors.affiliation: Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University Guangzhou, Guangdong, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Zhao-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Julin
authors.initials: J
authors.lastname: Xie
keywords: Negatively-charged aerosol; chronic wound; healing
references.citation: Proc Soc Exp Biol Med. 1957 Dec;96(3):807-9
references.pmid: 13505866
references.citation: Am Ind Hyg Assoc J. 1972 Jul;33(7):483-7
references.pmid: 4661169
references.citation: Zhonghua Shao Shang Za Zhi. 2005 Aug;21(4):266-9
references.pmid: 16185409
references.citation: Proc Soc Exp Biol Med. 1959 Jul;101(3):506-7
references.pmid: 13675298
references.citation: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Jun;43(7):694-9
references.pmid: 18444070
references.citation: Arch Dermatol. 1994 Apr;130(4):489-93
references.pmid: 8166487
references.citation: Wound Repair Regen. 2006 Sep-Oct;14(5):536-41
references.pmid: 17014664
references.citation: Proc Soc Exp Biol Med. 1958 Jun;98(2):412-4
references.pmid: 13554663
references.citation: Clin Dermatol. 2010 Sep-Oct;28(5):519-26
references.pmid: 20797512
references.citation: Curr Mol Med. 2012 Jan;12(1):14-26
references.pmid: 22082478
references.citation: J Gen Physiol. 1960 Nov;44:269-76
references.pmid: 13754552
references.citation: J Food Prot. 2001 Jan;64(1):113-6
references.pmid: 11198431
references.citation: Wound Repair Regen. 2009 Nov-Dec;17(6):763-71
references.pmid: 19903300
references.citation: Surg Technol Int. 2003;11:168-79
references.pmid: 12931299
references.citation: BMC Infect Dis. 2010 Apr 12;10:92
references.pmid: 20384999
references.citation: J Gen Physiol. 1958 Sep 20;42(1):69-82
references.pmid: 13575775
references.citation: Eur J Nucl Med. 1993 Dec;20(12):1201-13
references.pmid: 8299656
references.citation: Int Wound J. 2009 Dec;6(6):420-30
references.pmid: 20051094
references.citation: Zhonghua Wai Ke Za Zhi. 2005 Oct 1;43(19):1280-3
references.pmid: 16271231
references.citation: Science. 1976 Sep 24;193(4259):1209-13
references.pmid: 959834
references.citation: Arch Intern Med. 1973 Jan;131(1):60-73
references.pmid: 4569374
references.citation: Nature. 1979 Oct 4;281(5730):400-1
references.pmid: 225679
references.citation: Am J Phys Med. 1969 Jun;48(3):119-49
references.pmid: 4892343
references.citation: Chest. 1971 Nov;60(5):468-71
references.pmid: 5119885
references.citation: Intensive Care Med. 2006 Feb;32(2):315-317
references.pmid: 16432675
references.citation: J Appl Microbiol. 2002;93(1):144-8
references.pmid: 12067383
references.citation: Diabetes Metab Res Rev. 2012 Feb;28 Suppl 1:119-41
references.pmid: 22271737