title: A synthesis of all stereoisomers of tenuecyclamide A employing a fluorous-Fmoc strategy.
abstract: A concise liquid-phase combinatorial synthesis of all stereoisomers of Tenuecyclamide A was achieved using a mixture of D-/L-alanine with each stereoisomer encoded by a different f-Fmoc tag. The synthetic strategy using f-Fmoc reagents as the protecting group for amino acids has been demonstrated to be a useful method for diverse polypeptide analogue synthesis.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University , 1-501 Shiogamaguchi, Tempaku-ku, Nagoya 468-8502, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Eguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyazaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shioiri
authors.forename: Masato
authors.initials: M
authors.lastname: Matsugi
mesh_terms: D000409:Alanine / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles; C495939:tenuecyclamide A; D000409:Alanine