title: Exploring the functional brain network of Alzheimer's disease: based on the computational experiment.
abstract: The purpose of this study is to explore the changes in functional brain networks of AD patients using complex network theory. In this study, resting-state fMRI datasets of 10 AD patients and 11 healthy controls were collected. Time series of 90 brain regions were extracted from the fMRI datasets after preprocessing. Pearson correlation method was used to calculate the correlation coefficient between any two time series. Then, a wide threshold range was selected to transform the adjacency matrix to a binary matrix under a different threshold. The topology parameters of each binary network were calculated, and all of them were then averaged within a group. During the evolution, node betweenness and the Euclidean distance between the nodes were set as control factors. Each binary network of healthy controls underwent evolution of 100 steps in accordance with the evolution rules. Then, the topology parameters of the evolution network were calculated. Finally, support vector machine (SVM) was used to classify the network topology parameters of the evolution network and to determine whether evolution results matched the datasets from AD patients. We found there were differing degrees of decline in global efficiency, clustering coefficient, number of edges and transitivity in AD patients compared with healthy controls. The topology parameters of the evolution network tended toward those of the AD group. The results of SVM classification of the evolution network show that the evolution network had a greater probability to be classified as an AD patients group. A new biological marker for diagnosis of AD was provided through comparison of topology parameters between AD patients and healthy controls. The study of network evolution strategies enriched the method of brain network evolution. The use of SVM to classify the results of network evolution provides an objective criteria for determining evolution results.
authors.affiliation: Image Processing and Intelligent Control Key Laboratory of Education Ministry of China, Wuhan, China ; Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: YaPeng
authors.initials: Y
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Qin
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net; D060388:Support Vector Machine
references.citation: Neuroimage. 2008 Feb 15;39(4):1666-81
references.pmid: 18082428
references.citation: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5868-73
references.pmid: 22467830
references.citation: PLoS One. 2011;6(10):e25446
references.pmid: 22022397
references.citation: Brain. 2010 Apr;133(Pt 4):1224-38
references.pmid: 20354002
references.citation: Trends Cogn Sci. 2004 Sep;8(9):418-25
references.pmid: 15350243
references.citation: Nat Rev Neurosci. 2009 Mar;10(3):186-98
references.pmid: 19190637
references.citation: PLoS Comput Biol. 2005 Sep;1(4):e42
references.pmid: 16201007
references.citation: Int J Alzheimers Dis. 2011;2011:481903
references.pmid: 21629749
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Phys Rev Lett. 2003 Sep 26;91(13):138701
references.pmid: 14525344
references.citation: PLoS One. 2012;7(3):e33540
references.pmid: 22457774
references.citation: Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7937-41
references.pmid: 12796510
references.citation: Neuroimage. 2010 Mar;50(1):233-42
references.pmid: 20005962
references.citation: Neuroimage. 2010 Aug 15;52(2):508-14
references.pmid: 20441797
references.citation: Stroke. 2002 Jul;33(7):1840-4
references.pmid: 12105363
references.citation: Clin Neurophysiol. 2003 Mar;114(3):399-409
references.pmid: 12705420
references.citation: J Neurol Neurosurg Psychiatry. 2006 Jul;77(7):856-62
references.pmid: 16549415
references.citation: PLoS One. 2012;7(4):e35559
references.pmid: 22532859
references.citation: Spinal Cord. 2008 Feb;46(2):118-23
references.pmid: 17502876
references.citation: Neuroimage. 2009 Aug;47 Suppl 2:T90-7
references.pmid: 19286464
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Aug;76(2 Pt 2):026107
references.pmid: 17930104
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Nat Rev Neurosci. 2002 Aug;3(8):606-16
references.pmid: 12154362
references.citation: PLoS Comput Biol. 2009 Jun;5(6):e1000408
references.pmid: 19521503
references.citation: Science. 2010 Sep 10;329(5997):1358-61
references.pmid: 20829489
references.citation: PLoS One. 2011;6(6):e21745
references.pmid: 21738785
references.citation: Neuroimage. 2005 Jan 1;24(1):118-31
references.pmid: 15588603
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1081-6
references.pmid: 14722353
references.citation: Cell. 2012 Apr 27;149(3):708-21
references.pmid: 22541439
references.citation: Brain Connect. 2012;2(2):45-55
references.pmid: 22480296
references.citation: Behav Neurol. 2009;21(1):63-75
references.pmid: 19847046
references.citation: Neuroimage. 2010 Apr 15;50(3):1118-25
references.pmid: 20060050
references.citation: Hum Brain Mapp. 2012 Mar;33(3):552-68
references.pmid: 21391279
references.citation: J Int Neuropsychol Soc. 2012 Jan;18(1):39-48
references.pmid: 22005016
references.citation: Clin Neurophysiol. 2006 Nov;117(11):2521-31
references.pmid: 16997626
references.citation: Front Syst Neurosci. 2010 Sep 17;4:
references.pmid: 20948582
references.citation: Neuroimage. 2009 Feb 1;44(3):715-23
references.pmid: 19027073
references.citation: Neuroimage. 2011 May 1;56(1):235-45
references.pmid: 21238595
references.citation: Neuroscientist. 2009 Aug;15(4):333-50
references.pmid: 19458383
references.citation: J Exp Biol. 2008 Jun;211(Pt 11):1792-804
references.pmid: 18490395
references.citation: Cereb Cortex. 2007 Jan;17(1):92-9
references.pmid: 16452642
references.citation: PLoS Comput Biol. 2008 Jun 27;4(6):e1000100
references.pmid: 18584043