title: Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction.
abstract: In this review we summarize recent major advances in our understanding on the molecular mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary barrier dysfunction, highlighting the role of immune cells, inflammatory and noninflammatory signaling events, mechanical noxae, and the affected cellular and molecular entities and functions. Furthermore, we address novel aspects of resolution and repair of ALI, as well as putative candidates for treatment of ALI, including pharmacological and cellular therapeutic means.
authors.affiliation: Dept. of Internal Medicine, Justus Liebig Univ., Universities of Giessen and Marburg Lung Center, Klinikstrasse 33, 35392 Giessen, Germany. istvan.vadasz@innere.med.uni-giessen.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Herold
authors.forename: Nieves M
authors.initials: NM
authors.lastname: Gabrielli
authors.forename: István
authors.initials: I
authors.lastname: Vadász
mesh_terms: D055371:Acute Lung Injury / Q000503:physiopathology*; D000818:Animals; D015824:Blood-Air Barrier / Q000503:physiopathology*; D002196:Capillaries / Q000503:physiopathology*; D002199:Capillary Permeability; D002450:Cell Communication; D006801:Humans; D011650:Pulmonary Alveoli / Q000503:physiopathology*
keywords: alveolar-capillary barrier dysfunction; molecular mechanism; pharmacological and cell-based therapy; pulmonary edema; zaacute lung injury/acute respiratory distress syndrome