title: [The diagnostic importance of the new marker KIM-1 in kidney damage].
abstract: In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed. The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia. The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1) results in the formation of protein that can be considered as a diagnostic marker. This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.
authors.affiliation: Pracownia Markerów Nefrotoksyczności Środowiskowej, Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Marchewka
authors.forename: Joanna
authors.initials: J
authors.lastname: Płonka
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis* / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002460:Cell Line; D000072596:Hepatitis A Virus Cellular Receptor 1; D007687:Kidney Tubules, Proximal / Q000737:chemistry / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000378:metabolism; D011991:Receptors, Virus / Q000032:analysis* / Q000378:metabolism
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus