title: Bone-crack detection, targeting, and repair using ion gradients.
abstract: Bone cracks can be detected by utilizing the damaged matrix itself as both the trigger and the fuel. A crack in a material with a high mineral content such as bone generates ion gradients, which can be utilized for active targeting and treatment. This approach to targeting a biological structure augments current methods, which are focused on biomacromolecular interactions involving proteins and nucleic acids.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802 (USA) http://research.chem.psu.edu/axsgroup.
authors.forename: Vinita
authors.initials: V
authors.lastname: Yadav
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Freedman
authors.forename: Mark
authors.initials: M
authors.lastname: Grinstaff
authors.forename: Ayusman
authors.initials: A
authors.lastname: Sen
mesh_terms: D001842:Bone and Bones / Q000033:anatomy & histology / Q000737:chemistry* / Q000473:pathology*; D006801:Humans; D007477:Ions / Q000737:chemistry; D013314:Stress, Mechanical
chemical_list: D007477:Ions
keywords: bone repair; diffusiophoresis; micropumps; nanotechnology; quantum dots
references.citation: Angew Chem Int Ed Engl. 2006 Aug 18;45(33):5420-9
references.pmid: 16807962
references.citation: Biomaterials. 2007 May;28(15):2465-78
references.pmid: 17175021
references.citation: Chem Soc Rev. 2011 May;40(5):2109-19
references.pmid: 21340080
references.citation: Endocrinol Metab Clin North Am. 2012 Sep;41(3):507-25
references.pmid: 22877427
references.citation: Ann N Y Acad Sci. 2007 Nov;1117:209-57
references.pmid: 18056045
references.citation: JAMA. 2006 Dec 27;296(24):2968-9
references.pmid: 17190899
references.citation: Small. 2010 Feb 5;6(3):338-45
references.pmid: 20013944
references.citation: Small. 2010 Jan;6(2):159-67
references.pmid: 19911393
references.citation: J Int Med Res. 2009 Mar-Apr;37(2):407-16
references.pmid: 19383235
references.citation: Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8434-45
references.pmid: 22887874
references.citation: Proc Natl Acad Sci U S A. 1999 May 25;96(11):6223-8
references.pmid: 10339569
references.citation: Phys Chem Chem Phys. 2011 Jul 28;13(28):12755-7
references.pmid: 21655613
references.citation: Nat Med. 2012 Jan 29;18(2):307-14
references.pmid: 22286306
references.citation: Chemistry. 2005 Nov 4;11(22):6462-70
references.pmid: 16052651
references.citation: Adv Drug Deliv Rev. 2005 May 25;57(7):1049-76
references.pmid: 15876403
references.citation: Nanoscale. 2013 Feb 21;5(4):1273-83
references.pmid: 23166050
references.citation: Curr Biol. 2013 Apr 8;23(7):560-8
references.pmid: 23541731
references.citation: Expert Opin Pharmacother. 2008 Feb;9(3):491-8
references.pmid: 18220499
references.citation: ACS Nano. 2009 Jan 27;3(1):4-9
references.pmid: 19206241
references.citation: Chem Asian J. 2009 Sep 1;4(9):1402-10
references.pmid: 19621413
references.citation: Pharmacoeconomics. 2007;25(11):913-33
references.pmid: 17960951
references.citation: J Am Chem Soc. 2013 Jan 30;135(4):1406-14
references.pmid: 23308365
references.citation: Phys Chem Chem Phys. 2010 Feb 21;12(7):1423-35
references.pmid: 20126754
references.citation: Bioorg Med Chem. 2012 Mar 15;20(6):2131-40
references.pmid: 22341574
references.citation: J Am Chem Soc. 2012 Sep 26;134(38):15688-91
references.pmid: 22971044
references.citation: J Control Release. 2012 Jul 20;161(2):198-213
references.pmid: 22016072
references.citation: J Control Release. 2009 Jan 19;133(2):90-5
references.pmid: 18848962