title: Seroprevalence of hepatitis B and immune response to hepatitis B vaccination in Chinese college students mainly from the rural areas of western China and born before HBV vaccination integrated into expanded program of immunization.
abstract: The prevalence of hepatitis B surface antigen (HBsAg) in a population aged 15 y or older was high in China, but an immunization strategy for this population was unavailable. We investigated the seroprevalence of hepatitis B and immune response to HBV vaccine in Chinese college students (n=2040 participants), 11.1%, 80.8%, and 8.1% had confirmed, unknown and no HBV vaccination history, respectively. The seropositive rates for HBsAg, anti-HBs sole and anti-HBs plus anti-HBc were 12.6%, 25.7%, and 30.1%, respectively. The HBsAg seropositive rate was significantly lower in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (5.3%, 13.6%, and 12.6%, respectively, P=0.0019). The anti-HBs alone seropositive rate was significantly higher in participants with confirmed HBV vaccination history than in those with unknown or no vaccination history (37.6%, 25.3%, and 13.8%, respectively, P<0.0001). Participants negative for HBsAg, anti-HBs, and anti-HBc at baseline (n=600) were given three doses of recombinant HBV vaccine (GlaxoSmithKline) at month 0, 1, and 6. Robust immune response was elicited after two and three doses (seroprotective rate: 91.9% and 99.0%, respectively, and geometric mean concentration [GMC]: 95.8 and 742.6 IU/L, respectively). Fourteen months after the third dose, the anti-HBs seroprotective rate of the group remained more than 97%. The seroprotective rates and GMCs did not differ significantly by vaccination history. This study suggested that three doses of 20 μg HBV vaccine were needed for college students negative for HBsAg, anti-HBs, and anti-HBc to ensure high seroprotective rates and concentrations.
authors.affiliation: Department of Microbiology and Infectious Disease Center; School of Basic Medical Sciences; Peking University Health Science Center; Beijing, PR China.
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Liao
authors.affiliation: Guangxi University of Science and Technology; Liuzhou, PR China.
authors.forename: Zhen-Zuo
authors.initials: ZZ
authors.lastname: Zhou
authors.affiliation: Guangxi University of Science and Technology; Liuzhou, PR China.
authors.forename: Fu-Bang
authors.initials: FB
authors.lastname: Wei
authors.affiliation: Guangxi University of Science and Technology; Liuzhou, PR China.
authors.forename: Han-Ning
authors.initials: HN
authors.lastname: Qin
authors.affiliation: Guangxi University of Science and Technology; Liuzhou, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention; Nanning, PR China.
authors.forename: Rong-Cheng
authors.initials: RC
authors.lastname: Li
authors.affiliation: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention; Nanning, PR China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention; Nanning, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Nong
authors.affiliation: Department of Microbiology and Infectious Disease Center; School of Basic Medical Sciences; Peking University Health Science Center; Beijing, PR China.
authors.forename: Kui-Xia
authors.initials: KX
authors.lastname: Sun
authors.affiliation: Department of Microbiology and Infectious Disease Center; School of Basic Medical Sciences; Peking University Health Science Center; Beijing, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Microbiology and Infectious Disease Center; School of Basic Medical Sciences; Peking University Health Science Center; Beijing, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D008297:Male; D012424:Rural Population; D016036:Seroepidemiologic Studies; D013334:Students; D014611:Vaccination / Q000379:methods; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines
keywords: college students; hepatitis B; hepatitis B vaccine; immune response; seroprevalence
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