title: Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines.
abstract: Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz (Germany).
authors.forename: Lutz
authors.initials: L
authors.lastname: Nuhn
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hartmann
authors.forename: Björn
authors.initials: B
authors.lastname: Palitzsch
authors.forename: Bastian
authors.initials: B
authors.lastname: Gerlitzki
authors.forename: Edgar
authors.initials: E
authors.lastname: Schmitt
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zentel
authors.forename: Horst
authors.initials: H
authors.lastname: Kunz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019496:Cancer Vaccines / Q000737:chemistry* / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry* / Q000276:immunology; D006020:Glycopeptides / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008969:Molecular Sequence Data; D018396:Mucin-1 / Q000737:chemistry / Q000276:immunology; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology; D014867:Water / Q000737:chemistry
chemical_list: D019496:Cancer Vaccines; D018984:Epitopes, T-Lymphocyte; D006020:Glycopeptides; C060192:MUC1 protein, human; D018396:Mucin-1; D011109:Polymethacrylic Acids; D014614:Vaccines, Synthetic; D014867:Water; C011533:Duxon
keywords: HPMA; MUC1 glycopeptides; T-helper-cell epitope peptides; antitumor vaccines; polymer glycopeptide conjugates