title: Targeted therapies and hypoxia imaging.
abstract: Hypoxia-specific cytotoxins have long exhibited considerable promise for treating hypoxic tumors, however recent negative results in large scale clinical trials have highlighted the importance of selecting patients who are most likely to respond using hypoxia imaging methods. This review looks at the available hypoxia-specific cytotoxins and describes how existing hypoxia imaging methods can be best used to predict which tumors will respond. It then surveys prior studies which combine hypoxia-selective cytotoxin treatment with hypoxia imaging, and finally concludes with a discussion of what lessons can be learnt from previous experiences in order to improve the use of these cytotoxic agents in future clinical evaluations.
authors.affiliation: Department of Radiation Oncology, Stanford University, Stanford, CA, USA - egraves@stanford.edu.
authors.forename: R
authors.initials: R
authors.lastname: Ali
authors.forename: E E
authors.initials: EE
authors.lastname: Graves
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015687:Cell Hypoxia; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D018579:Patient Selection; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D010100:Oxygen