title: Interaction of aldehydes derived from lipid peroxidation and membrane proteins.
abstract: A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4-hydroxyalkenals, malondialdehyde (MDA) and acrolein, have received particular attention since they have been considered as toxic messengers that can propagate and amplify oxidative injury. In the 4-hydroxyalkenal class, 4-hydroxy-2-nonenal (HNE) is the most intensively studied aldehyde, in relation not only to its toxic function, but also to its physiological role. Indeed, HNE can be found at low concentrations in human tissues and plasma and participates in the control of biological processes, such as signal transduction, cell proliferation, and differentiation. Moreover, at low doses, HNE exerts an anti-cancer effect, by inhibiting cell proliferation, angiogenesis, cell adhesion and by inducing differentiation and/or apoptosis in various tumor cell lines. It is very likely that a substantial fraction of the effects observed in cellular responses, induced by HNE and related aldehydes, be mediated by their interaction with proteins, resulting in the formation of covalent adducts or in the modulation of their expression and/or activity. In this review we focus on membrane proteins affected by lipid peroxidation-derived aldehydes, under physiological and pathological conditions.
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università di Torino Torino, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pizzimenti
authors.forename: Eric
authors.initials: E
authors.lastname: Ciamporcero
authors.forename: Martina
authors.initials: M
authors.lastname: Daga
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Pettazzoni
authors.forename: Alessia
authors.initials: A
authors.lastname: Arcaro
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Cetrangolo
authors.forename: Rosalba
authors.initials: R
authors.lastname: Minelli
authors.forename: Chiara
authors.initials: C
authors.lastname: Dianzani
authors.forename: Alessio
authors.initials: A
authors.lastname: Lepore
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gentile
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Barrera
keywords: aldehydes; human diseases; lipid peroxidation; membrane proteins; signal transduction
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