title: Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.
abstract: We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.
authors.affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom.
authors.forename: Tom
authors.initials: T
authors.lastname: Cloke
authors.forename: Markus
authors.initials: M
authors.lastname: Munder
authors.forename: Philip
authors.initials: P
authors.lastname: Bergin
authors.forename: Shanthi
authors.initials: S
authors.lastname: Herath
authors.forename: Manuel
authors.initials: M
authors.lastname: Modolell
authors.forename: Graham
authors.initials: G
authors.lastname: Taylor
authors.forename: Ingrid
authors.initials: I
authors.lastname: Müller
authors.forename: Pascale
authors.initials: P
authors.lastname: Kropf
mesh_terms: D000328:Adult; D001119:Arginase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D018826:CD13 Antigens / Q000378:metabolism; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology* / Q000821:virology; D010641:Phenotype; D013046:Specific Gravity; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018826:CD13 Antigens; D001119:Arginase
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