title: The presence of prostate cancer at biopsy is predicted by a number of genetic variants.
abstract: Several single nucleotide polymorphisms (SNPs) have been associated with an elevated risk of prostate cancer risk. It is not established if they are useful in predicting the presence of prostate cancer at biopsy or if they can be used to define a low-risk group of men. In this study, 4,548 men underwent a prostate biopsy because of an elevated prostate specific antigen (PSA; ≥4 ng/mL) or an abnormal digital rectal examination (DRE). All men were genotyped for 11 selected SNPs. The effect of each SNP, alone and in combination, on prostate cancer prevalence was studied. Of 4,548 men: 1,834 (40.3%) were found to have cancer. A positive association with prostate cancer was seen for 5 of 11 SNPs studied (rs1800629, rs1859962, rs1447295, rs4430796, rs11228565). The cancer detection rate rose with the number of SNP risk alleles from 29% for men with no variant to 63% for men who carried seven or more risk alleles (OR = 4.2; p = 0.002). The SNP data did not improve the predictive power of clinical factors (age, PSA and DRE) for detecting prostate cancer (AUC: 0.726 vs. 0.735; p = 0.4). We were unable to define a group of men with a sufficiently low prevalence of prostate cancer that a biopsy might have been avoided. In conclusion, our data do not support the routine use of SNP polymorphisms as an adjunct test to be used on the context of prostate biopsy for Polish men with an abnormal screening test.
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Aniruddh
authors.initials: A
authors.lastname: Kashyap
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kluźniak
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokołorczyk
authors.forename: Adam
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authors.lastname: Gołąb
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sikorski
authors.forename: Marcin
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authors.lastname: Świtała
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authors.lastname: Borkowski
authors.forename: Andrzej
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authors.lastname: Borkowski
authors.forename: Andrzej
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authors.lastname: Antczak
authors.forename: Łukasz
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authors.lastname: Przybyła
authors.forename: Marek
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authors.lastname: Sosnowski
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authors.forename: Romuald
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authors.lastname: Zdrojowy
authors.forename: Paulina
authors.initials: P
authors.lastname: Sikorska-Radek
authors.forename: Józef
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authors.lastname: Matych
authors.forename: Jacek
authors.initials: J
authors.lastname: Wilkosz
authors.forename: Waldemar
authors.initials: W
authors.lastname: Różański
authors.forename: Jacek
authors.initials: J
authors.lastname: Kiś
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bar
authors.forename: Piotr
authors.initials: P
authors.lastname: Bryniarski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Paradysz
authors.forename: Konrad
authors.initials: K
authors.lastname: Jersak
authors.forename: Jerzy
authors.initials: J
authors.lastname: Niemirowicz
authors.forename: Piotr
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authors.lastname: Słupski
authors.forename: Piotr
authors.initials: P
authors.lastname: Jarzemski
authors.forename: Michał
authors.initials: M
authors.lastname: Skrzypczyk
authors.forename: Jakub
authors.initials: J
authors.lastname: Dobruch
authors.forename: Paweł
authors.initials: P
authors.lastname: Domagała
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Piotrowski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Dębniak
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Masojć
authors.forename: Thierry
authors.initials: T
authors.lastname: van de Wetering
authors.forename: Janusz
authors.initials: J
authors.lastname: Menkiszak
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Akbari
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019540:Area Under Curve; D001706:Biopsy; D051517:Digital Rectal Examination; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen
keywords: DRE; PSA; SNP; prostate biopsy; prostate cancer; screening