title: Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data.
abstract: Studies of the human microbiome, and microbial community ecology in general, have blossomed of late and are now a burgeoning source of exciting research findings. Along with the advent of next-generation sequencing platforms, which have dramatically increased the scope of microbiome-related projects, several high-performance sequence analysis pipelines (e.g. QIIME, MOTHUR, VAMPS) are now available to investigators for microbiome analysis. The subject of our manuscript, the graphical user interface-based Explicet software package, fills a previously unmet need for a robust, yet intuitive means of integrating the outputs of the software pipelines with user-specified metadata and then visualizing the combined data.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA, University of Colorado Microbiome Research Consortium, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO 80045, USA, Incubix Incorporated, Boulder, CO 80301, USA and Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Robertson
authors.forename: J Kirk
authors.initials: JK
authors.lastname: Harris
authors.forename: Brandie D
authors.initials: BD
authors.lastname: Wagner
authors.forename: David
authors.initials: D
authors.lastname: Granger
authors.forename: Kathy
authors.initials: K
authors.lastname: Browne
authors.forename: Beth
authors.initials: B
authors.lastname: Tatem
authors.forename: Leah M
authors.initials: LM
authors.lastname: Feazel
authors.forename: Kristin
authors.initials: K
authors.lastname: Park
authors.forename: Norman R
authors.initials: NR
authors.lastname: Pace
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Frank
mesh_terms: D019295:Computational Biology; D003196:Computer Graphics; D003628:Database Management Systems; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D054892:Metagenome; D064307:Microbiota / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012984:Software; D014584:User-Computer Interface
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