title: Epithelioid sarcoma-like (pseudomyogenic) hemangioendothelioma, clinically mimicking dermatofibroma, diagnosed by skin biopsy in a 30-year-old man.
abstract: Epithelioid sarcoma-like (pseudomyogenic) hemangioendothelioma (ESHE) represents a rare soft tissue and bone tumor that typically presents as nodule(s) in the distal extremities of young adults. The nodules traverse several tissue planes simultaneously and can involve the dermis, subcutis, skeletal muscle and bone. ESHE shares clinical and microscopic features with epithelioid sarcoma (ES), and, accordingly, is commonly misdiagnosed as ES. However, unlike ES, which has a poor prognosis, ESHE commonly follows an indolent course. Herein, we report a case of ESHE diagnosed by skin biopsy that clinically mimicked a dermatofibroma. We also provide clinical photographs of the lesions in various stages of development, representing information that has not been previously published, to our knowledge.
authors.affiliation: Department of Pathology, Emory University, Atlanta, GA, USA.
authors.forename: Lauren N
authors.initials: LN
authors.lastname: Stuart
authors.forename: Jerad M
authors.initials: JM
authors.lastname: Gardner
authors.forename: Scott R
authors.initials: SR
authors.lastname: Lauer
authors.forename: David K
authors.initials: DK
authors.lastname: Monson
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Parker
authors.forename: Mark A
authors.initials: MA
authors.lastname: Edgar
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D006390:Hemangioendothelioma / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008297:Male; D012509:Sarcoma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
keywords: hemangioendothelioma; leg tumor; pseudomyogenic; soft tissue tumor