title: Collaborative cancer epidemiology in the 21st century: the model of cancer consortia.
abstract: During the last two decades, epidemiology has undergone a rapid evolution toward collaborative research. The proliferation of multi-institutional, interdisciplinary consortia has acquired particular prominence in cancer research. Herein, we describe the characteristics of a network of 49 established cancer epidemiology consortia (CEC) currently supported by the Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI). This collection represents the largest disease-based research network for collaborative cancer research established in population sciences. We describe the funding trends, geographic distribution, and areas of research focus. The CEC have been partially supported by 201 grants and yielded 3,876 publications between 1995 and 2011. We describe this output in terms of interdisciplinary collaboration and translational evolution. We discuss challenges and future opportunities in the establishment and conduct of large-scale team science within the framework of CEC, review future prospects for this approach to large-scale, interdisciplinary cancer research, and describe a model for the evolution of an integrated Network of Cancer Consortia optimally suited to address and support 21st-century epidemiology.
authors.affiliation: Authors' Affiliations: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland; Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; Scientific Consulting Group, Inc., Gaithersburg, Maryland; and Stanford Prevention Research Center, Department of Medicine, and Department of Public Health and Policy, Stanford University School of Medicine, and Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, California.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Burgio
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
authors.forename: Brett M
authors.initials: BM
authors.lastname: Kaminski
authors.forename: Eric
authors.initials: E
authors.lastname: Derycke
authors.forename: Scott
authors.initials: S
authors.lastname: Rogers
authors.forename: Muin J
authors.initials: MJ
authors.lastname: Khoury
authors.forename: Daniela
authors.initials: D
authors.lastname: Seminara
mesh_terms: D004812:Epidemiologic Methods; D006801:Humans; D054547:National Cancer Institute (U.S.); D009369:Neoplasms / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
references.citation: Community Genet. 2003;6(3):171-7
references.pmid: 15237201
references.citation: Nat Rev Cancer. 2005 Dec;5(12):977-85
references.pmid: 16341085
references.citation: Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7
references.pmid: 19474294
references.citation: Cancer Causes Control. 2011 Mar;22(3):463-8
references.pmid: 21203821
references.citation: JAMA. 2011 Jan 5;305(1):59-67
references.pmid: 21205967
references.citation: Infect Agent Cancer. 2007 Sep 24;2:17
references.pmid: 17892589
references.citation: J BUON. 2006 Oct-Dec;11(4):415-8
references.pmid: 17309171
references.citation: Can J Surg. 2009 Apr;52(2):92-7
references.pmid: 19399202
references.citation: BJU Int. 2011 Jan;107(1):28-39
references.pmid: 20840664
references.citation: Epidemiology. 2007 Jan;18(1):13-7
references.pmid: 17179754
references.citation: Gastroenterology. 2011 Jan;140(1):73-81
references.pmid: 20727894
references.citation: Oral Oncol. 2009 Sep;45(9):743-6
references.pmid: 19442571
references.citation: Hered Cancer Clin Pract. 2011 Sep 07;9:8
references.pmid: 21899746
references.citation: Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1149-50
references.pmid: 20447911
references.citation: Hum Mutat. 2012 Jan;33(1):2-7
references.pmid: 21990146
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):197-9
references.pmid: 17301250
references.citation: Nat Genet. 2013 Feb;45(2):191-6
references.pmid: 23263487
references.citation: Gut. 2011 Aug;60(8):1029-37
references.pmid: 21406386
references.citation: Hum Mol Genet. 2011 Dec 15;20(24):4991-9
references.pmid: 21908515
references.citation: Public Health Genomics. 2011;14(1):1-8
references.pmid: 20051673
references.citation: Cancer Causes Control. 2009 May;20(4):491-6
references.pmid: 19132539
references.citation: Prostate. 2005 May 15;63(3):276-90
references.pmid: 15599943
references.citation: Breast Cancer Res. 2004;6(4):R375-89
references.pmid: 15217505
references.citation: BJU Int. 2007 Jun;99(6):1350-5
references.pmid: 17419707
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):704-10
references.pmid: 16614112
references.citation: Ann Intern Med. 2001 Oct 16;135(8 Pt 1):577-88
references.pmid: 11601929
references.citation: Genet Med. 2010 Nov;12(11):680-3
references.pmid: 20975567
references.citation: Nat Genet. 2011 Jul 10;43(8):785-91
references.pmid: 21743467
references.citation: Am J Epidemiol. 2012 May 1;175(9):962-9
references.pmid: 22491085
references.citation: Am J Prev Med. 2008 Aug;35(2 Suppl):S243-9
references.pmid: 18619406
references.citation: Endocr Relat Cancer. 2013 Mar 22;20(2):251-62
references.pmid: 23404857
references.citation: Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1295-6
references.pmid: 20338472
references.citation: Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):181-8
references.pmid: 23322363
references.citation: Sci Transl Med. 2010 Mar 10;2(22):22cm9
references.pmid: 20374998
references.citation: Genet Med. 2012 Jan;14(1):169-70
references.pmid: 22237448
references.citation: Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):189-200
references.pmid: 23242141
references.citation: JAMA. 2010 Sep 1;304(9):967-75
references.pmid: 20810374
references.citation: Prostate Cancer. 2013;2013:560857
references.pmid: 23476788
references.citation: Breast Cancer Res Treat. 2009 Jul;116(2):379-86
references.pmid: 18704680
references.citation: J Natl Cancer Inst. 2003 Apr 16;95(8):622-5
references.pmid: 12697855
references.citation: J Clin Bioinforma. 2011 Sep 16;1(1):24
references.pmid: 21923917
references.citation: Clin Transl Sci. 2009 Apr;2(2):143-9
references.pmid: 20443880
references.citation: Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2115-9
references.pmid: 21803842
references.citation: Breast Cancer Res. 2007;9(2):104
references.pmid: 17466083
references.citation: Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):571-5
references.pmid: 22374992
references.citation: Science. 2007 May 18;316(5827):1036-9
references.pmid: 17431139
references.citation: J Epidemiol. 2012;22(4):287-90
references.pmid: 22672913
references.citation: Int J Epidemiol. 2007 Aug;36(4):724-30
references.pmid: 17255350
references.citation: Hum Genet. 2013 Jan;132(1):5-14
references.pmid: 23064873
references.citation: Cancer Causes Control. 2010 Dec;21(12):2137-47
references.pmid: 20721616
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2331-43
references.pmid: 17982118
references.citation: Cancer Res. 2001 Jul 15;61(14):5420-4
references.pmid: 11454686
references.citation: Genet Med. 2007 Oct;9(10):665-74
references.pmid: 18073579
references.citation: Genome Med. 2011 Jul 14;3(7):46
references.pmid: 21787442
references.citation: AJNR Am J Neuroradiol. 2007 Apr;28(4):603-7
references.pmid: 17416804
references.citation: J Clin Oncol. 1999 Oct;17(10):3245-51
references.pmid: 10506626