title: Benefit sharing: an exploration on the contextual discourse of a changing concept.
abstract: BACKGROUND
  The concept of benefit sharing has been a topical issue on the international stage for more than two decades, gaining prominence in international law, research ethics and political philosophy. In spite of this prominence, the concept of benefit sharing is not devoid of controversies related to its definition and justification. This article examines the discourses and justifications of benefit sharing concept.
  
  
  CONCLUSIONS
  We examine the discourse on benefit sharing within three main spheres; namely: common heritage of humankind, access and use of genetic resources according to the Convention on Biological Diversity (CBD), and international clinical research. Benefit sharing has changed from a concept that is enshrined in a legally binding regulation in the contexts of common heritage of humankind and CBD to a non-binding regulation in international clinical research. Nonetheless, there are more ethical justifications that accentuate benefit sharing in international clinical research than in the contexts of common heritage of humankind and the CBD.
  
  
  CONCLUSIONS
  There is a need to develop a legal framework in order to strengthen the advocacy and decisiveness of benefit sharing practice in international health research. Based on this legal framework, research sponsors would be required to provide a minimum set of possible benefits to participants and communities in research. Such legal framework on benefit sharing will encourage research collaboration with local communities; and dispel mistrust between research sponsors and host communities. However, more research is needed, drawing from other international legal frameworks, to understand how such a legal framework on benefit sharing can be successfully formulated in international health research.
authors.affiliation: Centre for Biomedical Ethics and Law, Faculty of Medicine KU Leuven, Kapucijnenvoer 35, Box 7001, Leuven B-3000, Belgium. kris.dierickx@med.kuleuven.be.
authors.forename: Bege
authors.initials: B
authors.lastname: Dauda
authors.forename: Kris
authors.initials: K
authors.lastname: Dierickx
mesh_terms: D035843:Biomedical Research / Q000941:ethics / Q000331:legislation & jurisprudence / Q000639:trends; D003210:Concept Formation; D032984:Ethics, Research; D006801:Humans; D033181:Information Dissemination / Q000941:ethics / Q000331:legislation & jurisprudence; D007391:International Cooperation / Q000331:legislation & jurisprudence; D012935:Social Justice
references.citation: Bioethics. 2006 Sep;20(5):248-53
references.pmid: 17100008
references.citation: Bioethics. 2012 Jul;26(6):305-14
references.pmid: 21241344
references.citation: Am J Bioeth. 2012;12(11):42-4
references.pmid: 23072679
references.citation: Philos Ethics Humanit Med. 2012 Jan 17;7:7
references.pmid: 22251457
references.citation: Am J Bioeth. 2010 Jun;10(6):52-4
references.pmid: 20526975
references.citation: J Med Ethics. 2010 Aug;36(8):500-4
references.pmid: 20663769
references.citation: Plant Physiol. 2004 May;135(1):10-5
references.pmid: 15141062
references.citation: J Infect Dis. 2004 Mar 1;189(5):930-7
references.pmid: 14976611
references.citation: Bioethics. 2007 Jul;21(6):342-50
references.pmid: 17845458
references.citation: Hastings Cent Rep. 1998 Nov-Dec;28(6):26-34
references.pmid: 9868608
references.citation: J Med Ethics. 2007 Apr;33(4):205-9
references.pmid: 17400617
references.citation: Am J Bioeth. 2010 Jun;10(6):26-35
references.pmid: 20526966
references.citation: Am J Bioeth. 2010 Jun;10(6):36-7
references.pmid: 20526967
references.citation: Hastings Cent Rep. 2005 Jan-Feb;35(1):24-37
references.pmid: 15799498
references.citation: Planta Med. 2011 Jul;77(11):1221-7
references.pmid: 21674434
references.citation: Semin Speech Lang. 2003 Nov;24(4):263-74
references.pmid: 14722800
references.citation: Community Genet. 2000;3(2):88-92
references.pmid: 11865922
references.citation: Hastings Cent Rep. 1998 Nov-Dec;28(6):38-42
references.pmid: 9868610
references.citation: Dev World Bioeth. 2006 Dec;6(3):144-57
references.pmid: 17038006
references.citation: Dev World Bioeth. 2006 Dec;6(3):122-34
references.pmid: 17038004
references.citation: Bioethics. 2005 Oct;19(5-6):476-91
references.pmid: 16425485
references.citation: Hastings Cent Rep. 2004 May-Jun;34(3):17-27
references.pmid: 15281723
references.citation: Dev World Bioeth. 2006 Dec;6(3):ii
references.pmid: 17038002