title: Magnetic resonance susceptibility-weighted imaging versus other imaging modalities in detecting splenic siderotic lesions.
abstract: BACKGROUND
  Susceptibility-weighted imaging (SWI) has been proven to be superior to T2*-weighted imaging and also other existing magnetic resonance imaging (MRI) techniques for the detection of iron content and hemorrhage in the brain. The purpose of this study was to compare SWI with T1WI, T2WI and T2*WI in detecting splenic siderotic lesions.
  
  
  RESULTS
  Twenty-two patients with splenic siderotic nodule were imaged with non-contrast MRI T1WI, T2WI, T2*WI and SWI at 3.0 Tesla. Imaging data were independently analyzed by two experienced radiologists. The number of splenic siderotic nodules was counted, and the size (largest diameter) was measured. The conspicuity was calculated as the nodule to background parenchyma intensity ratio. We found that SWI detected a larger average number of splenic siderotic nodules than T1WI, T2WI, or T2*WI (all P<0.05). The average size of the nodules detected by SWI was larger than that of those detected by T1WI, T2WI or T2*WI (all P<0.05). SWI provided superior contrast and visibility for splenic siderotic nodules compared to any other sequence (all P<0.001).
  
  
  CONCLUSIONS
  SWI may be a better detection scheme for splenic siderotic nodules than T1WI, T2WI and T2*WI.
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Chuanming
authors.initials: C
authors.lastname: Li
authors.forename: Daiquan
authors.initials: D
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Mu
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012806:Siderosis / Q000175:diagnosis*; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology; D013158:Splenic Diseases / Q000175:diagnosis*; D055815:Young Adult
references.citation: Lancet. 2004 Jan 31;363(9406):357-62
references.pmid: 15070565
references.citation: Lancet. 2007 Dec 1;370(9602):1855-60
references.pmid: 18061062
references.citation: N Engl J Med. 2000 Nov 23;343(21):1529-35
references.pmid: 11087882
references.citation: J Comput Assist Tomogr. 1992 Mar-Apr;16(2):298-300
references.pmid: 1545029
references.citation: QJM. 1998 Sep;91(9):607-18
references.pmid: 10024915
references.citation: Radiology. 1995 Jun;195(3):753-6
references.pmid: 7754006
references.citation: N Engl J Med. 1994 Sep 1;331(9):574-8
references.pmid: 8047081
references.citation: Radiology. 1989 Sep;172(3):681-4
references.pmid: 2672092
references.citation: N Engl J Med. 2005 Sep 15;353(11):1135-46
references.pmid: 16162884
references.citation: J Comput Assist Tomogr. 1992 Jul-Aug;16(4):578-82
references.pmid: 1629417
references.citation: AJNR Am J Neuroradiol. 2009 Jan;30(1):19-30
references.pmid: 19039041
references.citation: AJNR Am J Neuroradiol. 2009 Feb;30(2):232-52
references.pmid: 19131406
references.citation: J Rheumatol. 2008 Jan;35(1):153-8
references.pmid: 18061976
references.citation: Ann N Y Acad Sci. 1988;526:224-33
references.pmid: 3291684
references.citation: Acta Radiol. 2004 Apr;45(2):119-29
references.pmid: 15191093
references.citation: Lancet. 1989 Jul 1;2(8653):27-30
references.pmid: 2567801
references.citation: Gastroenterology. 2010 Aug;139(2):393-408, 408.e1-2
references.pmid: 20542038
references.citation: Curr Opin Hematol. 2007 May;14(3):183-90
references.pmid: 17414205
references.citation: Radiology. 2003 May;227(2):332-9
references.pmid: 12732694
references.citation: J Am Soc Nephrol. 2006 Jul;17(7):2034-47
references.pmid: 16738019
references.citation: Radiology. 1996 Apr;199(1):13-22
references.pmid: 8633135
references.citation: Eur Heart J. 2001 Dec;22(23):2171-9
references.pmid: 11913479
references.citation: Magn Reson Med. 2004 Sep;52(3):612-8
references.pmid: 15334582
references.citation: Annu Rev Physiol. 2002;64:663-80
references.pmid: 11826284
references.citation: Semin Liver Dis. 2005 Nov;25(4):381-91
references.pmid: 16315132
references.citation: J Cardiovasc Magn Reson. 2008 Sep 25;10:42
references.pmid: 18817553