title: Postoperative plasma D-dimer value for predicting deep venous thrombosis following hip arthroplasty with nadroparin prophylaxis.
abstract: The aim of the study was to assess the value of D-dimer as an event predicitor for deep vein thrombosis (DVT) in patients given low molecular weight heparin (LMWH) after total hip arthroplasty (THA). Plasma D-dimer levels were obtained preoperatively and at days 1, 3, and 7 postoperatively in 83 consecutive patients undergoing THA treated with nadroparin prophylaxis plus intermittent pneumatic compression. Unilateral ascending venography was performed at postoperative day 7 or 8. There was a significant difference between the D-dimer levels in the DVT group (28 patients) and non-DVT group (55 patients) on each day (P<0.01). ROC analysis showed the AUC on postoperative days 1, 3 and 7 was 0.706, 0.712 and 0.772 respectively. The D-dimer concentration on postoperative day 1, day 3 or day 7 is of moderate predicting value of DVT in patients undergoing THA, treated with nadroparin prophylaxis plus intermittent pneumatic compression.
authors.affiliation: 1 Drum Tower Hospital affiliated to Medical School of Nanjing University, Nanjing, Jiangsu - China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xu
authors.forename: Dongquan
authors.initials: D
authors.lastname: Shi
authors.forename: Chengji
authors.initials: C
authors.lastname: Zhang
authors.forename: Dongyang
authors.initials: D
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.forename: Huajian
authors.initials: H
authors.lastname: Teng
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017762:Nadroparin / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011379:Prognosis; D020246:Venous Thrombosis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; D017762:Nadroparin; C036309:fibrin fragment D