title: Two new sphingolipids from the leaves of Piper betle L.
abstract: Two new sphingolipids, pipercerebrosides A (1) and B (2), were isolated from the leaves of Piper betle L. Their structures, including absolute configurations, were determined by spectroscopic analysis and chemical degradation. These two compounds did not show significant cytotoxic activity against the cancer cell lines K562 and HL-60 in a MTT assay.
authors.affiliation: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, Yunnan, China.
authors.forename: Duo-Zhi
authors.initials: DZ
authors.lastname: Chen
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Xiong
authors.forename: Kai
authors.initials: K
authors.lastname: Tian
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Guo
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D008745:Methylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D031721:Piper betle / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D013107:Sphingolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D013107:Sphingolipids; C587027:pipercerebroside A; C587028:pipercerebroside B
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