title: Expression of NF-kB and COX2 in colorectal cancer among native Indonesians: the role of inflammation in colorectal carcinogenesis.
abstract: OBJECTIVE
  to evaluate the expression of NF-kB and COX2 in native Indonesians with sporadic colorectal cancer (CRC).
  
  
  METHODS
  we conducted a matched-pair case-control study by acquiring both CRC and tumor-adjacent normal tissues from the same subjects. CRC patients who underwent surgery at Cipto Mangunkusumo Hospital, Jakarta, or Hasan Sadikin Hospital, Bandung, were enrolled in the study. The specimens were immunohistologically stained with antibody directed against p65 (RelA) to assess NF-kB expression and against human COX2 protein to assess COX2 expression.
  
  
  RESULTS
  sixty-seven specimens consisting of both CRC and tumor-adjacent normal tissues were analyzed. COX2 expression was positive in 39 CRC tissues (58.2%), but in only 19 tumor-adjacent normal tissues (28.4%; p=0.0002). NF-kB expression was positive in 47 CRC tissues (70.1%), but in only 27 tumor-adjacent normal tissues (40.3%; p<0.0001).
  
  
  CONCLUSIONS
  inflammation plays a role in the carcinogenesis of sporadic CRC in native Indonesians. This support potential use of nonsteroidal anti-inflammatory drugs as chemopreventive agents for CRC.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Murdani
authors.initials: M
authors.lastname: Abdullah
authors.forename: A Aziz
authors.initials: AA
authors.lastname: Rani
authors.forename: Aru W
authors.initials: AW
authors.lastname: Sudoyo
authors.forename: Dadang
authors.initials: D
authors.lastname: Makmun
authors.forename: Diah R
authors.initials: DR
authors.lastname: Handjari
authors.forename: Bethy S
authors.initials: BS
authors.lastname: Hernowo
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology*; D000328:Adult; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic; D003106:Colon / Q000737:chemistry / Q000473:pathology; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000032:analysis*; D005260:Female; D006801:Humans; D007214:Indonesia; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000032:analysis*; D012007:Rectum / Q000737:chemistry / Q000473:pathology
chemical_list: D016328:NF-kappa B; D051546:Cyclooxygenase 2