title: Mn₃[Co(CN)₆]₂@SiO₂ core-shell nanocubes: novel bimodal contrast agents for MRI and optical imaging.
abstract: Nanoprobes with dual modal imaging of magnetic resonance imaging (MRI) and two-photon fluorescence (TPF) can serve as promising platforms for clinical diagnosis. A wide range of molecules and nanoparticles have been investigated as agents for contrast enhanced MRI and fluorescence imaging in cancer diagnosis. However, a single material with dual modal imaging of MRI and TPF is rarely reported. We found that Mn₃[Co(CN)₆]₂@SiO₂ nanocubes can serve as agents for both T₁- and T₂-weighted MRI, and TPF imaging. The nanocubes coated with silica to form Mn₃[Co(CN)₆]₂@SiO₂ core-shell nanocubes were readily internalized by cells without showing cytotoxicity. In vitro tests, the core-shell nanocubes display relatively high longitudinal (r₁) and transverse (r₂) relaxivities, they also manifest a remarkable T₁ and T₂ contrast effects at in-vivo imaging of internal organs in Mice. Moreover, the core-shell nanocubes could offer high-resolution cell fluorescence imaging by two-photon excitation (720 nm) or by conventional fluorescence with 403- or 488-nm excitation.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: Hu
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhong
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhenbang
authors.initials: Z
authors.lastname: Liu
authors.forename: Haibao
authors.initials: H
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.forename: Qianwang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D004195:Disease Models, Animal; D064593:Heterografts; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis; D061848:Optical Imaging / Q000379:methods; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D003287:Contrast Media; D012822:Silicon Dioxide
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