title: Effects of rocuronium pretreatment on muscle enzyme levels following succinylcholine.
abstract: Succinylcholine revolutionized anaesthetic practice by providing intense neuromuscular blockade of very rapid onset and ultrashort duration, thereby greatly easing the maneuver of tracheal intubation. However the worth of succinylcholine is limited by the frequent occurrence of muscular side effects which manifest biochemically in the form of rise in serum creatine kinase (CK). The administration of small doses of nondepolarizing muscle relaxants before the administration of succinylcholine has been shown to decrease the incidence and severity of muscular side effects experienced by the patients. This study was aimed at evaluating the efficacy of technique in reducing the muscular side effects of succinylcholine, biochemically manifested as rise in CK. Sixty healthy adults were enrolled in the study who were scheduled for minor muscle cutting surgeries under general anaesthesia. They were assigned at random to two groups of thirty patients each. They randomly received succinylcholine for intubation and a precurarization dose of rocuronium followed by succinylcholine for intubation. Blood samples were drawn for estimation of serum creatinine kinase. There was a significantly raised CK in the succinylcholine group. In the precurarization group the rise in CK was prevented and the levels were significantly less as compared to the group which received succinylcholine alone. Present study concluded that precurarization with rocuronium was effective in reducing the succinylcholine-induced rise in creatinine kinase.
authors.affiliation: Department of Pharmacology & Therapeutics, Army Medical College (National University of Sciences & Technology), Rawalpindi, Pakistan.
authors.forename: Kulsoom
authors.initials: K
authors.lastname: Farhat
authors.forename: Akbar
authors.initials: A
authors.lastname: Waheed
authors.forename: Anwar Kamal
authors.initials: AK
authors.lastname: Pasha
authors.forename: Muhammad
authors.initials: M
authors.lastname: Tariq
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage* / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D052283:Creatine Kinase, MM Form / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010154:Pakistan; D011446:Prospective Studies; D000077123:Rocuronium; D016037:Single-Blind Method; D013390:Succinylcholine / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D000732:Androstanols; D015415:Biomarkers; D003473:Neuromuscular Nondepolarizing Agents; D052283:Creatine Kinase, MM Form; D013390:Succinylcholine; D000077123:Rocuronium