title: Perylenequinones: Isolation, Synthesis, and Biological Activity.
abstract: The perylenequinones are a novel class of natural products characterized by pentacyclic conjugated chromophore giving rise to photoactivity. Potentially useful light-activated biological activity, targeting protein kinase C (PKC), has been identified for several of the natural products. Recently discovered new members of this class of compound, as well as several related phenanthroperylenequinones, are reviewed. Natural product modifications that improve biological profiles, and avenues for the total synthesis of analogs, which are not available from the natural product series, are outlined. An overview of structure/function relationships is provided.
authors.affiliation: Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Mulrooey
authors.forename: Erin M
authors.initials: EM
authors.lastname: O'Brien
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Morgan
authors.forename: Marisa C
authors.initials: MC
authors.lastname: Kozlowski
keywords: Binaphthol; Chiral Biaryl; Natural Products; Perylenequinone; Photodynamic Therapy
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