title: Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells.
abstract: Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.
authors.affiliation: Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility (SSRF) Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Su
authors.forename: Yao
authors.initials: Y
authors.lastname: He
authors.forename: Min
authors.initials: M
authors.lastname: Yin
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001343:Autophagy / Q000502:physiology*; D002104:Cadmium / Q000633:toxicity*; D019187:Cadmium Compounds / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D007477:Ions; D016716:PC12 Cells; D045663:Quantum Dots / Q000633:toxicity*; D051381:Rats; D013691:Tellurium / Q000633:toxicity
chemical_list: D019187:Cadmium Compounds; D007477:Ions; D002104:Cadmium; D013691:Tellurium; C028337:cadmium telluride
keywords: autophagy; cadmium-based quantum dots; cytotoxicity; nanoscale effect