title: [Effect of the life activity factors of long-duration isolation on the chromosomal apparatus of human blood lymphocytes in vivo].
abstract: The purpose was to study consequences of long-duration (105-day) isolation and confinement on the rate of chromosomal aberrations in human blood lymphocytes in vivo. Blood samples for cytogenetic analysis were drawn from 6 test-subjects before and on completion of the experiment. Analysis of unstable chromosomal aberrations showed a statistically reliable increase (p < 0.05) in the rate of chromatid aberrations (virtually, 25-fold) in the form of single fragments as compared with baseline values. Rate of chromosome aberrations did not differ from baseline values except 1 test-subject with a dicentric and associated fragment found after the experiment.
authors.forename: L A
authors.initials: LA
authors.lastname: Repina
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D013997:Time Factors