title: [Histamine in regulation of bone remodeling processes].
abstract: Bone remodeling is under autocrine, paracrine, endocrine and central nervous system control. One of the potential endogenous factors affecting bone remodeling is histamine, an endogenous amine which acts as a mediator of allergic reactions and neuromediator, and induces production of gastric acid. Histamine H₁ receptor antagonists are widely used in the treatment of allergic conditions, H₂ receptor antagonists in peptic ulcer disease, and betahistine (an H₃ receptor antagonist and H₁ receptor agonist) is used in the treatment of Ménière's disease. Excess histamine release in mastocytosis and allergic diseases may lead to development of osteoporosis. Clinical and population-based studies on the effects of histamine receptor antagonists on the skeletal system have not delivered unequivocal results. Expression of mRNA of histamine receptors has been discovered in bone cells (osteoblasts and osteoclasts). Histamine synthesis has been demonstrated in osteoclast precursors. Histamine increases bone resorption both by direct effects on osteoclast precursors and osteoclasts, and indirectly, by increasing the expression of RANKL in osteoblasts. In in vivo studies, H₁ and H₂ receptor antagonists exerted protective effects on the bone tissue, although not in all experimental models. In the present article, in vitro and in vivo studies conducted so far, concerning the effects of histamine and drugs modifying its activity on the skeletal system, have been reviewed.
authors.affiliation: Katedra i Zakład Farmakologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Śląski Uniwersytet Medyczny w Katowicach.
authors.forename: Marek
authors.initials: M
authors.lastname: Wiercigroch
authors.forename: Joanna
authors.initials: J
authors.lastname: Folwarczna
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D006632:Histamine / Q000096:biosynthesis*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D008575:Meniere Disease / Q000378:metabolism; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism* / Q000517:prevention & control; D010437:Peptic Ulcer / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D053245:RANK Ligand / Q000187:drug effects / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D020011:Protective Agents; D053245:RANK Ligand; D006632:Histamine