title: Biocatalytically triggered co-assembly of two-component core/shell nanofibers.
abstract: For the development of applications and novel uses for peptide nanostructures, robust routes for their surface functionalization, that ideally do not interfere with their self-assembly properties, are required. Many existing methods rely on covalent functionalization, where building blocks are appended with functional groups, either pre- or post-assembly. A facile supramolecular approach is demonstrated for the formation of functionalized nanofibers by combining the advantages of biocatalytic self-assembly and surfactant/gelator co-assembly. This is achieved by enzymatically triggered reconfiguration of free flowing micellar aggregates of pre-gelators and functional surfactants to form nanofibers that incorporate and display the surfactants' functionality at the surface. Furthermore, by varying enzyme concentration, the gel stiffness and supramolecular organization of building blocks can be varied.
authors.affiliation: Pure and Applied Chemistry Department/WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
authors.forename: Yousef M
authors.initials: YM
authors.lastname: Abul-Haija
authors.forename: Sangita
authors.initials: S
authors.lastname: Roy
authors.forename: Pim W J M
authors.initials: PW
authors.lastname: Frederix
authors.forename: Nadeem
authors.initials: N
authors.lastname: Javid
authors.forename: Vineetha
authors.initials: V
authors.lastname: Jayawarna
authors.forename: Rein V
authors.initials: RV
authors.lastname: Ulijn
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D055162:Biocatalysis; D002851:Chromatography, High Pressure Liquid; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009842:Oligopeptides / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D055672:Static Electricity; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D013501:Surface-Active Agents; C047981:arginyl-glycyl-aspartic acid; D000469:Alkaline Phosphatase
keywords: biocatalysis; co-assembly; peptides; surface functionality; transformation