title: Intravenous versus oral outpatient antibiotic therapy for pediatric acute osteomyelitis.
abstract: The optimal route (oral versus intravenous) of antibiotic administration for pediatric acute osteomyelitis is not well established. Seventy-eight children from our university hospital and 17 children at our county hospital were treated for acute osteomyelitis. The rates of intravenous antibiotics upon discharge were 95% versus 65% (P=0.002), respectively. The recurrence rate and line complication rates were 10% and 24% at the university hospital, compared to 0% (P=0.34) and 6% (P=0.29) at the county hospital. Based on this data, a prospective comparison between intravenous and early oral antibiotic therapy for pediatric acute osteomyelitis is recommended.
authors.affiliation: Study performed at the Department of Pediatric Orthopaedic Surgery, Case Western Reserve University, University Hospitals Case Medical Center , Cleveland , OH.
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Liu
authors.forename: Hadeel
authors.initials: H
authors.lastname: Abaza
authors.forename: Priyesh
authors.initials: P
authors.lastname: Mehta
authors.forename: Jennifer
authors.initials: J
authors.lastname: Bauer
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Cooperman
authors.forename: Allison
authors.initials: A
authors.lastname: Gilmore
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy*; D010045:Outpatients; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: intravenous antibiotics; oral antibiotics; pediatric acute osteomyelitis
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