title: Emerging treatment options for meibomian gland dysfunction.
abstract: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics; it influences a great number of people, and is the leading cause of evaporative dry eye. Given the increased recognition of the importance of MGD, a great amount of attention has been paid to therapies targeting this condition. The traditional treatments of MGD consist of warm compresses and lid hygiene for removing an obstructed meibum, as well as antibiotics and anti-inflammatory agents to improve the quality of the meibum. However, each of these treatments has a different shortcoming and the treatment of MGD remains challenging. Despite the numerous possible treatment options for MGD, it is still difficult to obtain complete relief of signs and symptoms. This review focuses on current emerging treatment options for MGD including intraductal meibomian gland probing, emulsion eye drops containing lipids, the LipiFlow® thermal pulsation system, N-acetyl-cysteine, azithromycin, oral supplementation with omega-3 essential fatty acids, and cyclosporine A.
authors.affiliation: Department of Ophthalmology, Peking University First Hospital, Key Laboratory of vision Loss and Restoration, Ministry of Education, Beijing, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qiao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yan
keywords: dry eye; emerging treatment; meibomian gland dysfunction
references.citation: Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):1922-9
references.pmid: 21450913
references.citation: Curr Eye Res. 2012 Apr;37(4):272-8
references.pmid: 22324772
references.citation: Ocul Surf. 2004 Apr;2(2):149-65
references.pmid: 17216085
references.citation: Cornea. 2012 Apr;31(4):396-404
references.pmid: 22222996
references.citation: Biomed Pharmacother. 1988;42(8):513-9
references.pmid: 3066412
references.citation: Eye Contact Lens. 2011 Sep;37(5):298-301
references.pmid: 21617536
references.citation: Can J Ophthalmol. 2008 Apr;43(2):170-9
references.pmid: 18347619
references.citation: Cornea. 2010 Oct;29(10):1145-52
references.pmid: 20622668
references.citation: Clin Ophthalmol. 2007 Mar;1(1):3-10
references.pmid: 19668461
references.citation: Br J Ophthalmol. 2002 Dec;86(12):1403-7
references.pmid: 12446375
references.citation: Ophthalmology. 2000 Apr;107(4):631-9
references.pmid: 10768324
references.citation: Pediatr Res. 2007 Oct;62(4):483-8
references.pmid: 17667842
references.citation: J Ocul Pharmacol Ther. 2006 Feb;22(1):47-53
references.pmid: 16503775
references.citation: Eye Contact Lens. 2013 May;39(3):e1-3
references.pmid: 22415153
references.citation: Graefes Arch Clin Exp Ophthalmol. 1999 May;237(5):435-8
references.pmid: 10333113
references.citation: Clin Exp Ophthalmol. 2013 Aug;41(6):524-30
references.pmid: 23145471
references.citation: Cornea. 2010 Dec;29(12):1333-45
references.pmid: 20847669
references.citation: Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):2050-64
references.pmid: 21450919
references.citation: J Cataract Refract Surg. 2005 Apr;31(4):661-3
references.pmid: 15899439
references.citation: Cornea. 2010 Aug;29(8):930-3
references.pmid: 20531168
references.citation: Ophthalmology. 2000 May;107(5):967-74
references.pmid: 10811092
references.citation: Invest Ophthalmol Vis Sci. 1986 Apr;27(4):486-91
references.pmid: 3957566
references.citation: Ophthalmol Clin North Am. 2003 Mar;16(1):37-42
references.pmid: 12683247
references.citation: Lipids. 2001 Sep;36(9):1007-24
references.pmid: 11724453
references.citation: Surv Ophthalmol. 2007 Jul-Aug;52(4):369-74
references.pmid: 17574063
references.citation: CLAO J. 1998 Jul;24(3):159-65
references.pmid: 9684074
references.citation: Am J Ophthalmol. 2003 Oct;136(4):593-602
references.pmid: 14516798
references.citation: Invest Ophthalmol Vis Sci. 1991 Oct;32(11):2970-5
references.pmid: 1917401
references.citation: Ophthalmic Plast Reconstr Surg. 2012 Nov-Dec;28(6):416-8
references.pmid: 22836802
references.citation: J Ocul Pharmacol Ther. 2010 Aug;26(4):329-33
references.pmid: 20653477
references.citation: Cornea. 2010 Jul;29(7):781-8
references.pmid: 20489573
references.citation: Trans Am Ophthalmol Soc. 2008;106:336-56
references.pmid: 19277245
references.citation: Eye (Lond). 2005 Jun;19(6):657-60
references.pmid: 15332095
references.citation: Curr Eye Res. 2011 Feb;36(2):79-87
references.pmid: 21281063
references.citation: Br J Ophthalmol. 1981 Feb;65(2):108-11
references.pmid: 7459311
references.citation: J Drug Deliv. 2012;2012:604204
references.pmid: 22506123
references.citation: N Engl J Med. 1989 Feb 2;320(5):265-71
references.pmid: 2783477
references.citation: Invest Ophthalmol Vis Sci. 1991 May;32(6):1932-7
references.pmid: 2032812
references.citation: Graefes Arch Clin Exp Ophthalmol. 2009 Jun;247(6):821-9
references.pmid: 19101718
references.citation: Ocul Surf. 2007 Apr;5(2):75-92
references.pmid: 17508116
references.citation: Cornea. 2006 Feb;25(2):171-5
references.pmid: 16371776
references.citation: J Ocul Pharmacol Ther. 2012 Feb;28(1):49-52
references.pmid: 21751879
references.citation: Biomed Eng Online. 2010 Mar 26;9:18
references.pmid: 20346157
references.citation: Adv Exp Med Biol. 2002;506(Pt A):495-9
references.pmid: 12613951
references.citation: Eye (Lond). 1997;11 ( Pt 1):75-8
references.pmid: 9246280
references.citation: Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5623-9
references.pmid: 20538995
references.citation: Int J Chron Obstruct Pulmon Dis. 2006;1(4):425-34
references.pmid: 18044098
references.citation: Ophthalmic Physiol Opt. 1990 Apr;10(2):144-8
references.pmid: 2371060
references.citation: Curr Eye Res. 2003 Feb;26(2):89-94
references.pmid: 12815527
references.citation: Invest Ophthalmol Vis Sci. 2011 Mar 30;52(4):1930-7
references.pmid: 21450914
references.citation: J Am Optom Assoc. 1980 Mar;51(3):243-51
references.pmid: 6154727
references.citation: Acta Med Croatica. 2005;59(4):337-40
references.pmid: 16334742
references.citation: Eye Contact Lens. 2007 Jan;33(1):38-44
references.pmid: 17224677
references.citation: Eye Contact Lens. 2003 Apr;29(2):96-9
references.pmid: 12695712
references.citation: Curr Opin Ophthalmol. 2000 Dec;11(6):478-83
references.pmid: 11141645
references.citation: Ophthalmology. 2004 Apr;111(4):783-91
references.pmid: 15051213
references.citation: Cornea. 2010 Aug;29(8):871-7
references.pmid: 20508503