title: Arterial stiffness determined according to the cardio-ankle vascular index(CAVI) is associated with mild cognitive decline in community-dwelling elderly subjects.
abstract: OBJECTIVE
  The purpose of this study was to determine the cross-sectional relationship between the cognitive function and cardio-ankle vascular index(CAVI) in Japanese community-dwelling elderly subjects.
  
  
  METHODS
  A total of 179 Japanese community-dwelling elderly subjects were recruited for this study. The age, height, weight, gender and past medical history(cardiovascular disease, hypertension, diabetes mellitus, hyperlipidemia) of each participant was recorded. In addition, the degree of arterial stiffness was determined according to the CAVI, while the cognitive function was assessed using the Mini-Mental State Examination(MMSE). After dividing the cohort into two groups according to the MMSE score(≤26, ＞26), we used a multiple regression analysis to assign the level of the cognitive function as a dependent variable.
  
  
  RESULTS
  The data were statistically analyzed for the 174 participants(84 men and 90 women) who completed the data collection process without omissions. A multivariate logistic regression analysis showed that a higher weight(Odds Ratio [OR]: 1.05, 95% Confidence Interval [95% CI]: 1.00- 1.11, p=0.03), male gender(OR: 3.13, 95% CI: 1.05-9.34, p=0.04) and lower CAVI(OR: 0.68, 95% CI: 0.48-0.96, p=0.03) were significantly correlated with a higher MMSE score. We also found significant correlations between the MMSE and weight(OR: 1.11, 95% CI: 1.03-1.19, p=0.01) and CAVI(OR: 0.57, 95% CI: 0.33-0.98, p=0.04) in elderly men only using a gender-specific analysis.
  
  
  CONCLUSIONS
  We found that the elderly subjects with a high CAVI exhibited a worse cognitive function even after adjusting for age, height, weight and gender. This finding therefore indicates the usefulness of the CAVI in the early detection of dementia.
authors.affiliation: Department of Physical Therapy, Human Health Sciences, Kyoto University Graduate School of Medicine.
authors.forename: Taiki
authors.initials: T
authors.lastname: Yukutake
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamada
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukutani
authors.forename: Shu
authors.initials: S
authors.lastname: Nishiguchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kayama
authors.forename: Takanori
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Daiki
authors.initials: D
authors.lastname: Adachi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hotta
authors.forename: Saori
authors.initials: S
authors.lastname: Morino
authors.forename: Yuto
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Hidenori
authors.initials: H
authors.lastname: Arai
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply*; D055109:Ankle Brachial Index / Q000379:methods*; D015415:Biomarkers / Q000032:analysis*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012111:Residence Characteristics; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers