title: Transcranial doppler sonography diagnostic value for the cerebral flow velocity changes in the interictal phase of classic migraine.
abstract: BACKGROUND
  An imbalance of the cerebrovascular response during functional activation of the brain has been postulated as a factor in the pathophysiology of migraine. The purpose of this study was to determine the transcranial doppler sonography (TDS) diagnostic value for the cerebral flow velocity changes in the interictal phase of classic migraine.
  
  
  METHODS
  This study was carried out on 46 patients (23 cases and 23 controls). We used Doppler instrument via trans-temporal window and detected middle cerebral artery, anterior cerebral artery and posterior cerebral artery by 2 MHz probe. The flow velocity in the posterior cerebral artery before, during and immediately after stimulation was recorded. Stimulation was done using a flickering light in 100 seconds.
  
  
  RESULTS
  At the baseline, the middle cerebral artery had more peak systolic velocity in migraineurs than the control group. Although peak systolic velocity changes in the mid-photic period is not statistically significant. On the other hand, post-photic peak systolic velocity increased significantly. The diagnostic accuracy of the peak systolic volume (PSV) changes in the posterior cerebral artery (PCA) for the migraine was 72.3%.
  
  
  CONCLUSIONS
  This stimulation we found altered cerebral vasomotor reactivity in the interictal phase in migraineurs with visual aura. This seemed to be an unavoidable hindrance for the wider implementation of functional TCD in diagnostic work up of migraine patients.
authors.affiliation: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Sedighi
authors.forename: Hossein
authors.initials: H
authors.lastname: Ali Ebrahimi
authors.forename: Shirin
authors.initials: S
authors.lastname: Jabbarpour
authors.forename: Kaveh
authors.initials: K
authors.lastname: Shafiee
keywords: Migraine with aura; Photo stimulation; Transcranial Doppler sonography (TCD)
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