title: Water-soluble diiron hexacarbonyl complex as a CO-RM: controllable CO-releasing, releasing mechanism and biocompatibility.
abstract: A water soluble diiron hexacarbonyl complex, [Fe2{μ-SCH2CH(OH)CH2(OH)}2(CO)6] (1), was synthesised by reacting thioglycol with Fe3(CO)12 in THF. This diiron complex was employed as carbon monoxide releasing molecule (CO-RM). The CO-releasing was initiated via substitution of the bound CO by cysteamine (CysA, a clinic medicine). Further decomposition of the substituted products led to at least partially the formation of monoiron(II) dicarbonyl species via oxidative process while releasing more CO under inert atmosphere. Three intermediates generated in the CO-releasing process were spectroscopically identified. The kinetics of the decomposition of complex 1 was first-order process for both the complex and CysA, respectively. Under open atmosphere, the CO-releasing mechanism altered due to the involvement of oxygen in the decomposition of complex 1. The system showed minimal cytotoxicity in two selected arbitrarily cell lines, QSG-7701 and HepG2, with IC50 at the scale of 100 μmol L(-1).
authors.affiliation: College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. xiaoming.liu@mail.zjxu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Long
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Jiang
authors.forename: Xiu
authors.initials: X
authors.lastname: Wang
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Xiao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D008422:Materials Testing; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D014867:Water; D002248:Carbon Monoxide; D007501:Iron