title: Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra.
abstract: BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy.
authors.affiliation: Bioinformatics Infrastructure Facility, Gauhati University, Guwahati - 781014, Assam, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Verma
authors.forename: Dhirendra Kumar
authors.initials: DK
authors.lastname: Sharma
authors.forename: Rituparna
authors.initials: R
authors.lastname: Sarma
authors.forename: Hasnahana
authors.initials: H
authors.lastname: Chetia
authors.forename: Juri
authors.initials: J
authors.lastname: Saikia
references.citation: Bioinformatics. 2007 Nov 1;23(21):2947-8
references.pmid: 17846036
references.citation: J Chem Inf Model. 2011 Oct 24;51(10):2515-27
references.pmid: 21877713
references.citation: Nat Rev Neurol. 2009 Jun;5(6):311-22
references.pmid: 19498435
references.citation: Protein Sci. 1999 Dec;8(12):2589-97
references.pmid: 10631974
references.citation: EMBO J. 1992 Mar;11(3):917-22
references.pmid: 1547788
references.citation: EMBO J. 1986 Apr;5(4):823-6
references.pmid: 3709526
references.citation: Proteins. 1997;Suppl 1:50-8
references.pmid: 9485495
references.citation: Mol Phylogenet Evol. 2006 Jun;39(3):628-44
references.pmid: 16488160
references.citation: Eur J Hum Genet. 2001 Mar;9(3):226-30
references.pmid: 11313763
references.citation: Curr Opin Neurobiol. 2007 Jun;17(3):325-30
references.pmid: 17419049
references.citation: J Biol Chem. 1997 Oct 3;272(40):25296-303
references.pmid: 9312147
references.citation: Protein Sci. 1998 Sep;7(9):1884-97
references.pmid: 9761470
references.citation: EMBO J. 1991 Aug;10(8):2105-10
references.pmid: 2065656
references.citation: Biochem Biophys Res Commun. 1997 Sep 18;238(2):633-7
references.pmid: 9299565
references.citation: Diabetes. 2000 Mar;49(3):436-44
references.pmid: 10868966
references.citation: J Mol Biol. 2007 Apr 20;368(1):283-301
references.pmid: 17337005
references.citation: J Affect Disord. 2010 Apr;122(1-2):174-8
references.pmid: 19664825
references.citation: J Abnorm Psychol. 2007 Feb;116(1):86-94
references.pmid: 17324019
references.citation: J Mol Biol. 1998 Jul 3;280(1):1-9
references.pmid: 9653027
references.citation: Eur J Neurosci. 1993 Jan 1;5(1):1-14
references.pmid: 8074744
references.citation: J Neurodev Disord. 2009 Sep;1(3):185-96
references.pmid: 19966931
references.citation: Neuron. 1991 May;6(5):845-58
references.pmid: 2025430
references.citation: Cell. 2003 Jan 24;112(2):257-69
references.pmid: 12553913