THERMODYNAMIC CHARACTERIZATION OF METAL PHTHALOCYANINES-HUMAN SERUM ALBUMIN INTERACTIONS.
The temperature dependence of the binding constants for human serum albumin and sulfonated metal-phthalocyanines were estimated by fluorescence spectroscopy. Stern-Volmer's analysis and Chipman's fits provided binding data for van't Hoff calculations of the thermodynamic parameters governing these interactions. Results show that the formations of the HSA- phthalocyanine complexes are favorable processes by both the ΔH° and ΔS°. However, the formation of HSA-AIPcS4has a stronger dependence than HSA-ZnPcS4on ΔS°.
Department of Natural Science & Mathematics, Chemistry Program, Savannah State University, Savannah, GA 31404.
Cecil L
CL
Jones
Chakeeta
C
Jones
Lana
L
Thomas
Dissociation constant; Fluorescence; Photodynamic therapy; Phthalocyanines; Stern-Volmer’s analysis; Thermodynamics; van’t Hoff analysis