The murine common deletion: mitochondrial DNA 3,860-bp deletion after irradiation.
This study demonstrates that mice, similar to humans, have a common mitochondrial DNA deletion (3,860 bp) that encodes 5 transfer RNA genes and 5 polypeptide genes that is related to aging, tissue type and radiotoxicity. Our research indicates that the deletion ratio in the liver was significantly higher than in the brain and gut tissues of 8-month-old mice, as compared to 8-week-old mice. Our results also demonstrate that tissue type, oxidative metabolic capacity and radiosensitivity influence the 3,860-bp deletion level. Therefore, this 3,860-bp deletion content may serve as a biomarker of aging and oxidative damage in mice.
Department of Radiation Oncology, University of Florida, Cancer and Genetics Research Complex, Gainesville, Florida 32610.
Steven B
SB
Zhang
David
D
Maguire
Mei
M
Zhang
Zhenhuan
Z
Zhang
Amy
A
Zhang
Liangjie
L
Yin
Lurong
L
Zhang
Luquiang
L
Huang
Sadasivan
S
Vidyasagar
Steven
S
Swarts
Paul
P
Okunieff
D000375:Aging / Q000235:genetics / Q000528:radiation effects; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D017353:Gene Deletion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000235:genetics* / Q000528:radiation effects*; D012343:RNA, Transfer / Q000235:genetics
D004272:DNA, Mitochondrial; D012343:RNA, Transfer