[Equilibrium solubility of ginkgo flavonoid components in water and PBS of different pHs with mass fraction weight coefficient method].
OBJECTIVE
To descript the equilibrium solubility of ginkgo flavonoid components in water and PBS of different pHs.


METHODS
The HPLC method was adopted to determine the concentration of quercetin, kaempferol and isorhamnetin in ginkgo biloba extracts, and the equilibrium solubility of the three components in water and PBS of different pHs. Furthermore, the mass fraction weight coefficient method was adopted to express the integrated equilibrium solubility and oil-water distribution coefficient of ginkgo flavonoid components.


RESULTS
Ginkgo flavonoid components were well dissoluble in water, with the maximum equilibrium solubility of 408.29 mg x L(-1) at pH 7.8. Therefore, it could be preliminarily predicted that ginkgo flavonoid components had higher application value, and could provide guiding basis for further development of preparations.


CONCLUSIONS
By comparing the results of the direct addition method and the mass fraction weight coefficient method, we found that the mass fraction weight coefficient method was more scientific and reasonable. The tentative study could provide ideas to property characterization of traditional Chinese medicine components.
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. liudan0513@yeah.net
Dan
D
Liu
Xiao-Bin
XB
Jia
Wei
W
Xiao
D005419:Flavonoids / Q000737:chemistry*; D020441:Ginkgo biloba / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012995:Solubility
D005419:Flavonoids