The path(way) less traveled.
In this issue of Blood, Mathewson et al characterized targeting a novel intracellular pathway with an agent known to induce potent antitumor effects but now also appears to potently suppress inflammatory responses by dendritic cells (DCs) and prevent graft-vs-host disease (GVHD). Identifying agents that can suppress GVHD yet not compromise graft-vs-tumor (GVT) effects remains a paramount goal in allogeneic hematopoietic stem cell transplantation (HSCT).
UNIVERSITY OF CALIFORNIA DAVIS SCHOOL OF MEDICINE.
Mehrdad
M
Abedi
William J
WJ
Murphy
D000818:Animals; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D000075687:NEDD8 Protein; D011499:Protein Processing, Post-Translational; D014452:Ubiquitins / Q000378:metabolism*
D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; C513172:Nedd8 protein, mouse; D014452:Ubiquitins