In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract.
Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it.
Assistant Professor, Drug Discovery Laboratory, Department of Pharmacology, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India.
Aditya
A
Ganeshpurkar
Varsha
V
Diwedi
Yash
Y
Bhardwaj
Methika; Trigonella foenum-graecum; α-Amylase; α-glucosidase