Association analyses identifying two common susceptibility loci shared by psoriasis and systemic lupus erythematosus in the Chinese Han population.
BACKGROUND
Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci shared by psoriasis and SLE in the Chinese Han population.


METHODS
In total, 20 single nucleotide polymorphisms (SNPs) in 17 previously reported psoriasis susceptibility loci and 34 SNPs from 24 previously reported SLE susceptibility loci were investigated in our initial psoriasis and SLE GWAS dataset. Among these SNPs, we selected two SNPs (rs8016947 and rs4649203) with association values of p<5×10(-2) for both diseases in the GWAS data for further investigation in psoriasis (7260 cases and 9842 controls) and SLE (2207 cases and 9842 controls) using a Sequenom MassARRAY system.


RESULTS
We found that these two SNPs (rs8016947 and rs4649203) in two loci (NFKBIA and IL28RA) were associated with psoriasis and SLE with genome-wide significance (Pcombined<5×10(-8) in psoriasis and Pcombined<5×10(-8) in SLE): rs8016947 at NFKBIA (Pcombined-psoriasis=3.90×10(-10), Pcombined-SLE=1.08×10(-13)) and rs4649203 at IL28RA (Pcombined-psoriasis=3.91×10(-12), Pcombined-SLE=9.90×10(-9)).


CONCLUSIONS
These results showed that two common susceptibility loci (NFKBIA and IL28RA) are shared by psoriasis and SLE in the Chinese Han population.
Department of Dermatology, Institute of Dermatology No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.
Yang
Y
Li
Hui
H
Cheng
Xian-bo
XB
Zuo
Yu-jun
YJ
Sheng
Fu-sheng
FS
Zhou
Xian-fa
XF
Tang
Hua-yang
HY
Tang
Jin-ping
JP
Gao
Zheng
Z
Zhang
Su-ming
SM
He
Yong-mei
YM
Lv
Kun-ju
KJ
Zhu
Da-yan
DY
Hu
Bo
B
Liang
Jun
J
Zhu
Xiao-dong
XD
Zheng
Liang-dan
LD
Sun
Sen
S
Yang
Yong
Y
Cui
Jian-jun
JJ
Liu
Xue-jun
XJ
Zhang
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
Genetics