Hemodynamics of the Edwards Sapien XT transcatheter heart valve in noncircular aortic annuli.
OBJECTIVE
During implantation of transcatheter aortic valves into severe calcified aortic annuli, misdeployments due to asymmetric shapes of the target region were reported. Whether the resultant stent deformations influence valve performance has not been quantified. The objective of this study was to investigate in vitro hemodynamics of the Edwards Sapien XT (Edwards Lifesciences, Irvine, Calif) after valve deployment in noncircular aortic annuli.


METHODS
Six Edwards Sapien XT valves were implanted into a model of the aortic annulus with different shapes (elliptical, triangular, and bulged compared with ideal circular) and investigated in a pulsatile flow simulator. Leakage was determined by ultrasonic flow measurements, and leaflet coaptation was visualized by high-speed video. In addition, the origin of leakage was investigated under static pressure.


RESULTS
The lowest amount of leakage occurred in the ideal circular shape, whereas in most of the noncircular configurations increased transvalvular leakage due to paravalvular leaks and folds at the free edges of the leaflets was found, more often by implantation of the valve within a triangular annulus shape. Implantation of the valves into the elliptical configuration with the prosthesis commissure directed to the longitudinal axis of the annular plane showed similar values compared with the circular annulus. Pressure gradients were not influenced by the valve distortion.


CONCLUSIONS
Implantation of the Edwards Sapien XT transcatheter valve into non-circular-shaped aortic annuli leads to increased leakage. Annulus shape and relative position of the prosthesis are main determinants of leakage. Implantation into elliptical annuli, as found in bicuspid aortic valves, seems feasible.
Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Luebeck, Germany.
Michael
M
Scharfschwerdt
Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Luebeck, Germany.
Roza
R
Meyer-Saraei
Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Luebeck, Germany.
Claudia
C
Schmidtke
Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Luebeck, Germany. Electronic address: herzchir@medinf.mu-luebeck.de.
Hans-Hinrich
HH
Sievers
D001021:Aortic Valve / Q000473:pathology* / Q000503:physiopathology*; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002114:Calcinosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D006439:Hemodynamics; D006801:Humans; D008422:Materials Testing; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D011474:Prosthesis Design