Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial.
OBJECTIVE
To compare the effect of two strategies (enhanced hand hygiene vs meticillin-resistant Staphylococcus aureus (MRSA) screening and decolonisation) alone and in combination on MRSA rates in surgical wards.


METHODS
Prospective, controlled, interventional cohort study, with 6-month baseline, 12-month intervention and 6-month washout phases.


METHODS
33 surgical wards of 10 hospitals in nine countries in Europe and Israel.


METHODS
All patients admitted to the enrolled wards for more than 24 h.


METHODS
The two strategies compared were (1) enhanced hand hygiene promotion and (2) universal MRSA screening with contact precautions and decolonisation (intranasal mupirocin and chlorhexidine bathing) of MRSA carriers. Four hospitals were assigned to each intervention and two hospitals combined both strategies, using targeted MRSA screening.


METHODS
Monthly rates of MRSA clinical cultures per 100 susceptible patients (primary outcome) and MRSA infections per 100 admissions (secondary outcome). Planned subgroup analysis for clean surgery wards was performed.


RESULTS
After adjusting for clustering and potential confounders, neither strategy when used alone was associated with significant changes in MRSA rates. Combining both strategies was associated with a reduction in the rate of MRSA clinical cultures of 12% per month (adjusted incidence rate ratios (aIRR) 0.88, 95% CI 0.79 to 0.98). In clean surgery wards, strategy 2 (MRSA screening, contact precautions and decolonisation) was associated with decreasing rates of MRSA clinical cultures (15% monthly decrease, aIRR 0.85, 95% CI 0.74 to 0.97) and MRSA infections (17% monthly decrease, aIRR 0.83, 95% CI 0.69 to 0.99).


CONCLUSIONS
In surgical wards with relatively low MRSA prevalence, a combination of enhanced standard and MRSA-specific infection control approaches was required to reduce MRSA rates. Implementation of single interventions was not effective, except in clean surgery wards where MRSA screening coupled with contact precautions and decolonisation was associated with significant reductions in MRSA clinical culture and infection rates.


BACKGROUND
clinicaltrials.gov identifier: NCT00685867.
Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.
Andie S
AS
Lee
Ben S
BS
Cooper
Surbhi
S
Malhotra-Kumar
Annie
A
Chalfine
George L
GL
Daikos
Carolina
C
Fankhauser
Biljana
B
Carevic
Sebastian
S
Lemmen
José Antonio
JA
Martínez
Cristina
C
Masuet-Aumatell
Angelo
A
Pan
Gabby
G
Phillips
Bina
B
Rubinovitch
Herman
H
Goossens
Christian
C
Brun-Buisson
Stephan
S
Harbarth
Infection Control < Infectious Diseases; Surgery