Diterpenoids from Acanthopanax brachypus Harms.
Four diterpenoids, including two new ones, namely noracanthopanin A (1) and acanthopanolide B (2), and two known ones, ent-pimara-9(11),15-dien-19-oic acid (3) and ent-kaur-16-en-19-oic acid (4), were isolated from the stem bark of Acanthopanax brachypus Harms. Their structures were elucidated by physicochemical and spectroscopic analyses. Compound 1 and 2 exhibited moderate cytotoxicities against HO-8910 cells with IC50 values of 65.21±0.23 and 31.43±1.01 μg/ml, respectively, and 2 showed selective weak cytotoxicity against SMMC-7721 cells (IC50 89.67±2.54 μg/ml).
College of Chemistry & Chemical Engineering, Longdong University, Qingyang 745000, P. R. China, (phone: +86-934-8658532; fax: +86-934-8651531). hhb-88@126.com.
Hao-Bin
HB
Hu
Xu-Dong
XD
Zheng
Huai-Sheng
HS
Hu
Yun
Y
Wu
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D028001:Eleutherococcus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry / Q000378:metabolism
C588025:3a,7a,12-trihydroxy-16-norcassan-8,11,13-trien-13-al; C588026:8,14-11,12-diepoxy-5,12-dihydroxy-3-oxo-10-abiet-13(15)-ene-16,18-diocic acid 16,12-lactone; D004224:Diterpenes
Acanthopanax brachypus; Acanthopanolide B; Cytotoxic activity; Diterpenoids; Noracanthopanin A