Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche.
In the past years, our view of the molecular and cellular mechanisms that ensure the self-renewal of the skin has dramatically changed. Several populations of stem cells have been identified that differ in their spatio-temporal contribution to their compartment in steady-state and damaged conditions, suggesting that epidermal stem cell heterogeneity is far greater than previously anticipated. There is also increasing evidence that these different stem cells require a tightly controlled spatial and temporal communication between other skin residents to carry out their function.
1] Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain. [2].
Guiomar
G
Solanas
Salvador Aznar
SA
Benitah
D000818:Animals; D006801:Humans; D008954:Models, Biological; D012867:Skin / Q000166:cytology*; D055153:Stem Cell Niche / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology