Responses of growth performance and proinflammatory cytokines expression to fish oil supplementation in lactation sows' and/or weaned piglets' diets.
The study was conducted to investigate whether dietary fish oil could influence growth of piglets via regulating the expression of proinflammatory cytokines. A split-plot experimental design was used with sow diet effect in the main plots and differing piglet diet effect in the subplot. The results showed that suckling piglets from fish oil fed dams grew rapidly (P < 0.05) than control. It was also observed that these piglets had higher ADG, feed intake, and final body weight (P < 0.05) during postweaning than those piglets from lard fed dams. Furthermore, there was a significant decrease (P < 0.01) in the expression of interleukin 6 and tumor necrosis factor- α in longissimus dorsi muscle. In contrast, there was a tendency (P < 0.10) towards lower ADG and higher feed:gain in weaned piglets receiving fish oil compared with those receiving lard. Meanwhile, splenic proinflammatory cytokines expression was increased (P < 0.01) in piglets receiving fish oil during postweaning period. The results suggested that 7% fish oil addition to sows' diets alleviated inflammatory response via decreasing the proinflammatory cytokines expression in skeletal muscle and accelerated piglet growth. However, 7% fish oil addition to weaned piglets' diets might decrease piglet growth via increasing splenic proinflammatory cytokines expression.
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Jie
J
Luo
Feiruo
F
Huang
Chenglin
C
Xiao
Zhengfeng
Z
Fang
Jian
J
Peng
Siwen
S
Jiang
D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004032:Diet; D019587:Dietary Supplements; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D018836:Inflammation Mediators / Q000378:metabolism; D007774:Lactation / Q000187:drug effects* / Q000235:genetics; D008892:Milk / Q000737:chemistry; D009132:Muscles / Q000187:drug effects; D011247:Pregnancy; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D034421:Sus scrofa / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D014886:Weaning; D015430:Weight Gain / Q000187:drug effects
D016207:Cytokines; D005227:Fatty Acids; D005395:Fish Oils; D018836:Inflammation Mediators