Chrotacumines E and F, two new chromone-alkaloid analogs from Dysoxylum acutangulum (Meliaceae) leaves.
A chemical investigation of the alkaloidal fraction of Dysoxylum acutangulum leaves led to the isolation and characterization of two new chromone alkaloid analogs named chrotacumines E and F (1 and 2, resp.). Structure elucidation of 1 and 2 was achieved by spectroscopic analyses, including 2D-NMR. Both of these alkaloids exhibited modest activities as tyrosinase inhibitors with 29.2 and 25.8% inhibition at 100 μg/ml, respectively.
Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia (phone: +603-89471490; fax: +603-89435380).
Mohd
M
Izwan Mohd Lazim
Intan
I
Safinar Ismail
Khozirah
K
Shaari
Jalifah
J
Abd Latip
Nabil
N
Ali Al-Mekhlafi
Hiroshi
H
Morita
D000363:Agaricales / Q000201:enzymology; D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D002942:Circular Dichroism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D029582:Meliaceae / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding
D000470:Alkaloids; D002867:Chromones; D006576:Heterocyclic Compounds, 4 or More Rings; D010880:Piperidines; C588022:chrotacumine E; C588023:chrotacumine F; D014442:Monophenol Monooxygenase
Alkaloids; Chromone alkaloids; Chrotacumines E and F; Dysoxylum acutangulum; Inhibitors; Tyrosinase