Germinoma in two brothers: case report.
We present a third reported case of intracranial germinomas occurring in two brothers. They underwent chemotherapy and radiotherapy after biopsy and are doing well for 10 years and 20 months, respectively. The pertinent literatures are reviewed, and the possible role of heredity in the pathogenesis of familial occurrence of germinomas is discussed.
Department of Neurosurgery, Shiga University of Medical Science.
Naoki
N
Nitta
Tadateru
T
Fukami
Kazuhiko
K
Nozaki
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D004392:Dwarfism / Q000209:etiology; D005047:Etoposide / Q000008:administration & dosage; D005192:Family Health; D018237:Germinoma / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007037:Hypothyroidism / Q000209:etiology; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D035781:Siblings; D015173:Supratentorial Neoplasms / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003336:Tectum Mesencephali / Q000473:pathology*; D017287:Ventriculoperitoneal Shunt; D014786:Vision Disorders / Q000209:etiology; D055815:Young Adult
D005047:Etoposide; D002945:Cisplatin