[Therapeutic efficacy of salbutamol and dexamethasone added into whole lung lavage fluid in patients with pneumoconiosis].
OBJECTIVE
To investigate the therapeutic efficacy and safety of salbutamol and dexamethasone added into large-volume whole lung lavage (WLL) fluid in patients with pneumoconiosis.


METHODS
A total of 176 patients with pneumoconiosis were randomly divided into control group (n=86) and treatment group (n=90). The control group received WLL with 0.9% sodium chloride solution, while for the treatment group, salbutamol and dexamethasone were added into the WLL fluid for both lungs at the 1st and 4th WLLs.Before and after WLL, the pulmonary wheezing, arterial partial pressure of oxygen (Pa02), peak airway pressure(Pa peak), amount of intrapulmonary residual fluid, forced expiratory volume in one second (FEVw) (72 h later),diffusion capacity for carbon monoxide (DLCO ), and forced vital capacity (FVC) were measured for comparison between the two groups.


RESULTS
After WLL, the treatment group had a significantly lower detection rate of pulmonary wheezing than the control group ( 13.3% vs 29.1 %, x2=5.028, ?=0.025), and the control group had a significantly higher incidence rate of pulmonary wheezing than the treatment group (21.8% vs 3.7%, 0R=5.423,95%CI 2.036-9.568 ). Compared with the control group, the treatment group had significantly higher Pa02 and significantly lower Pa peak and amount of intrapulmonary residual fluid (t =2.163 -4.132, P<0.05) and significantly higher FEV1, DLCO, and FVC (t=1.986-2.345, P<0.05) after WLL.


CONCLUSIONS
Salbutamol and dexamethasone added into large-volume WLL fluid may effectively alleviate bronchial spasm, reduce hypoxemia, and decrease Pa peak in patients with pneumoconiosis, thus promoting lung function recovery after WLL.
Department of respiratory diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province 442000, China.
Jian-yong
JY
Zhu
Yu-qin
YQ
Zeng
Gong
G
Chen
Jun
J
Kuang
Li-bo
LB
Zhang
Yong-lan
YL
Wang
D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid; D003907:Dexamethasone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000628:therapy*; D055815:Young Adult
D003907:Dexamethasone; D000420:Albuterol