Antidepressant-induced tardive syndrome: a retrospective epidemiological study.
BACKGROUND
The impact of using antidepressant on the occurrence of tardive syndrome is rarely studied. Here we aimed to investigate the prevalence of various types of antidepressant induced tardive syndrome.


METHODS
This study was conducted by means of a retrospective survey. Subjects receiving antidepressant(s) for over 6 months, but no other agents that may cause involuntary movements, were consecutively recruited. Tardive syndrome was evaluated in every included subject. Possible confounding medical conditions were carefully ruled out.


RESULTS
Of the 158 included subjects, 22 (14.0 %) were found to have at least one tardive syndrome. The prevalence of subtypes of tardive syndromes was: tardive dystonia: 10.8 %, tardive dykinesia: 3.2 %, tardive tremor: 1.3 %, tardive parkinsonism: 1.3 %, tardive tics: 1.3 %, tardive sensory syndrome: 1.3 %, and tardive myoclonus: 0.6 %. Using serotonin-norepinephrine reuptake inhibitors and previous marital status significantly increase the risk of tardive syndrome.


CONCLUSIONS
This study showed that antidepressants may induce various types of tardive syndrome, of which tardive dystonia is the predominant form. Clinicians should be cautious of this infrequent but distressing adverse effect when using antidepressants.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College at Medicine, Kaohsiung, Taiwan.
Y
Y
Lee
P-Y
PY
Lin
Y-Y
YY
Chang
M-Y
MY
Chong
A T
AT
Cheng
D017109:Akathisia, Drug-Induced / Q000150:complications / Q000453:epidemiology*; D000928:Antidepressive Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000150:complications / Q000453:epidemiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012678:Sensation Disorders / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology*; D013577:Syndrome; D013624:Taiwan / Q000453:epidemiology
D000928:Antidepressive Agents