Association between MDR1 C3435T polymorphism and risk of breast cancer.
The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to the carcinogenesis. Many published studies have evaluated the association between the MDR1 C3435T polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive. To derive a more precise estimation of the association between MDR1 C3435T polymorphism and risk of breast cancer, we performed a meta-analysis comprised of 10 case-control studies, including 5282 breast cancer cases and 7703 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the association. The overall results indicated that the variant genotypes were associated with a significantly increased risk of breast cancer (TT versus CC: OR=1.45, 95% CI=1.14-1.30, TT versus CT/CC: OR=1.13, 95% CI=1.04-1.23, TT/CT versus CC: OR=1.22, 95% CI=1.02-1.46). Our results suggest that the MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer.
The First Clinical Medical College, Nanjing Medical University, Nanjing, China.
Zhaoming
Z
Wang
Ting
T
Wang
Jianmin
J
Bian
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1
ABCB1; ATP; ATP-binding cassette sub-family B gene 1; Breast cancer; CI; HWE; Hardy–Weinberg equilibrium; MALDI-TOF MS; MDR; MDR1; Meta-analysis; OR; P-glycoprotein; P-gp; PCR; PCR-RFLP; SNP; TP53; adenosine triphosphate; confidence intervals; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; multi-drug resistance; multi-drug resistance gene 1; odds ratio; polymerase chain reaction; polymerase chain reaction-restriction fragment length polymorphism; single-nucleotide polymorphism; tumor protein gene 53