No genetic influence for childhood behavior problems from DNA analysis.
OBJECTIVE
Twin studies of behavior problems in childhood point to substantial genetic influence. It is now possible to estimate genetic influence using DNA alone in samples of unrelated individuals, not relying on family-based designs such as twins. A linear mixed model, which incorporates DNA microarray data, has confirmed twin results by showing substantial genetic influence for diverse traits in adults. Here we present direct comparisons between twin and DNA heritability estimates for childhood behavior problems as rated by parents, teachers, and children themselves.


METHODS
Behavior problem data from 2,500 UK-representative 12-year-old twin pairs were used in twin analyses; DNA analyses were based on 1 member of the twin pair with genotype data for 1.7 million DNA markers. Diverse behavior problems were assessed, including autistic, depressive, and hyperactive symptoms. Genetic influence from DNA was estimated using genome-wide complex trait analysis (GCTA), and the twin estimates of heritability were based on standard twin model fitting.


RESULTS
Behavior problems in childhood-whether rated by parents, teachers, or children themselves-show no significant genetic influence using GCTA, even though twin study estimates of heritability are substantial in the same sample, and even though both GCTA and twin study estimates of genetic influence are substantial for cognitive and anthropometric traits.


CONCLUSIONS
We suggest that this new type of "missing heritability," that is, the gap between GCTA and twin study estimates for behavior problems in childhood, is due to nonadditive genetic influence, which will make it more difficult to identify genes responsible for heritability.
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London. Electronic address: maciej.trzaskowski@kcl.ac.uk.
Maciej
M
Trzaskowski
Philip S
PS
Dale
Robert
R
Plomin
D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000235:genetics*; D004739:England; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D014427:Twins; D014852:Wales
D005819:Genetic Markers
behavior problems; cognitive abilities; genome-wide complex trait analysis (GCTA); heritability; twin study