Flavonoids with anti-HSV activity from the root bark of Artocarpus lakoocha.
From the MeOH extract of the root bark of Artocarpus lakoocha, a new compound 5,7,2',4'-tetrahydroxy-6-geranyl-3-prenyl-flavone (1) was isolated, along with three known flavonoids (+)-afzelechin-3-O-alpha-L-rhamnopyranoside (2), (+)-catechin (3) and cudraflavone C (4). Evaluation of these isolates for inhibitory effects against Herpes simplex virus (HSV) types 1 and 2 was carried out using the inactivation method. Compounds 1 and 4 showed moderate and weak activity against both types of HSV, respectively, whereas 2 and 3 were devoid of activity.
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Boonchoo.Sr@chula.ac.th
Boonchoo
B
Sritularak
Kullasap
K
Tantrakarnsakul
Vimolmas
V
Lipipun
Kittisak
K
Likhitwitayawuid
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells
D000998:Antiviral Agents; D005419:Flavonoids