Inhibition of HSP90 could be possible mechanism for anti-cancer property of amniotic membrane.
Amniotic membrane (AM), the innermost layer of the fetal membrane, is considered as a suitable candidate for cancer therapy. In order to develop the AM as a new cancer therapeutic approach, it is essential to understand the molecular mechanism of the AM anti-cancer properties. Previous studies demonstrated that anti-proliferative effects of the AM on tumor cells were associated with induction of cell cycle arrest. Moreover, it has been shown that unknown substances in the AM induce apoptosis in cancer cells and inhibit angiogenesis in tumors. In contrast to the effects of the AM, heat shock proteins (HSPs), in particular HSP90, play a crucial role in development of tumorgenesis. HSP90 inhibits apoptosis in cancer cells and enhances angiogenesis and cell cycle progression. Based on the opposite effects of the amniotic membrane ingredients and HSP90, we hypothesized here that possible mechanism of the AM anti-cancer effects is through inhibition of HSP90.
Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: niknejad@sbmu.ac.ir.
Hassan
H
Niknejad
Ghasem
G
Yazdanpanah
Masoumeh
M
Mirmasoumi
Hassan
H
Abolghasemi
Habibollah
H
Peirovi
Abolhassan
A
Ahmadiani
D000650:Amnion / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000032:analysis* / Q000494:pharmacology; D063646:Carcinogenesis / Q000187:drug effects*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D008954:Models, Biological
D000970:Antineoplastic Agents; D018841:HSP90 Heat-Shock Proteins