Case report: Papillary mesothelioma of the peritoneum with foamy cell lining.
A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary lining, that expressed cytokeratins 7, 5/6 and calretinin as well as nuclear WT-1 and apical membrane staining for thrombomodulin, podoplanin D2-40 and HBME-1. In contrast, lining cells were CD68 negative. Foamy cell change has been reported in isolated cases as solid cords but not as a diffuse change in the mesothelial papillary lining. This phenomenon prompts differential diagnoses with abdominal and renal papillary clear cell tumours, which were discarded after a characteristic mesothelial immunophenotype was demonstrated.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4679576081031834.
Department of Pathology, University of Medicine and Pharmacy, Str, Gh, Marinescu nr 38, Targu Mures, Romania. stolnicu@gmx.net.
Simona
S
Stolnicu
Enoe
E
Quiñonez
Monica
M
Boros
Claudiu
C
Molnar
Isabel
I
Dulcey
Francisco F
FF
Nogales
D000328:Adult; D001194:Asbestos / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008654:Mesothelioma / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D001194:Asbestos