Probing interactions in fungal PKS.
Biosynthesis of polyketides can depend on interactions between the acyl carrier proteins (ACPs) which hold the growing chains and their enzymatic partners. In this issue of Chemistry & Biology, Bruegger and colleagues demonstrate that mechanism-based probes tethered to the ACPs of fungal nonreducing polyketide synthases can provide insights into these contacts.
Molecular and Structural Enzymology Group, UMR 7365 CNRS-UL:IMoPA, Lorraine University, Faculté de Médecine, Batiment Biopôle, 9 Avenue de la Forêt de Haye, BP 184, 54506 Vandoeuvre-lès-Nancy, France. Electronic address: kira.weissman@univ-lorraine.fr.
Kira J
KJ
Weissman
D048630:Polyketide Synthases / Q000378:metabolism*
D048630:Polyketide Synthases