Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria.
We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.
Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Kyuha
K
Chong
Taeyun
T
Ku
Phei Er
PE
Saw
Sangyong
S
Jon
Ji-Ho
JH
Park
Chulhee
C
Choi
D000873:Anthracenes; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008027:Light; D008823:Micelles; D008928:Mitochondria / Q000378:metabolism*; D053758:Nanoparticles / Q000008:administration & dosage; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000737:chemistry
D000873:Anthracenes; D008823:Micelles; D010714:Phosphatidylethanolamines; D017319:Photosensitizing Agents; C038089:1,2-distearoylphosphatidylethanolamine; D011092:Polyethylene Glycols; D010569:Perylene; C004965:hypericin; C028210:monomethoxypolyethylene glycol