Deformity stabilization and improvement in men with untreated Peyronie's disease.
OBJECTIVE
To define predictors of the deformity stabilisation and improvement in men with untreated Peyronie's disease (PD).


METHODS
The study population consisted of patients with PD-associated uniplanar curvature, who opted for no treatment and were followed for at least 12 months. All patients had deformity assessment (DA) performed on initial presentation and at follow-up. Stabilisation of PD was defined as no change between DAs (±10°), while improvement and progression were defined as ≥10° change. Patients were subdivided into different groups based on time to presentation: ≤6 months (A), 7-12 months (B), and 13-18 months (C). Multivariable analysis was used to define predictors of stabilisation and improvement.


RESULTS
In all, 176 men met the inclusion criteria. The mean age was 54 years, with a mean (sd) PD duration of 9 (12) months and mean curvature of 42 (27)°. In all, 67% of the entire population had no change in deformity over time, 12% improved with a mean (sd) change of 27 (14)°, and 21% worsened with a mean (sd) change of 22 (11)°. On multivariate analysis, predictors of stabilisation included: time to presentation of >6 months (odds ratio [OR] 2.4, P < 0.01), per decade increase in age (OR 1.5, P < 0.05), and age (r = 0.32, P < 0.05). Predictors of improvement included: time to presentation of ≤6 months (OR 4.1, P < 0.001), and per decade decrease in age (OR 2.1, P < 0.01).


CONCLUSIONS
In men with uniplanar curvature, PD stabilisation and improvement rates change with time-to-presentation and patient age. These data may aid in counselling patients with PD.
Male Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Boback M
BM
Berookhim
Judy
J
Choi
Byron
B
Alex
John P
JP
Mulhall
D000367:Age Factors; D003863:Depression / Q000453:epidemiology; D018450:Disease Progression; D006801:Humans; D018783:Impotence, Vasculogenic / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010411:Penile Induration / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology; D010413:Penis / Q000002:abnormalities*; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
Peyronie's disease; natural history; penile induration; penis