Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia.
Alveolar capillary dysplasia (ACD) with misalignment of pulmonary veins (MPV) is a lethal neonatal lung disease. Death from ACD/MPV is caused by hypoxia, but the role of the MPV is unknown. Using 3-dimensional reconstruction of ACD/MPV lung tissue, we report that the veins in MPV are intrapulmonary shunt vessels, and speculate that MPV contributes to the poor prognosis.
Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Csaba
C
Galambos
Division of Nephrology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA.
Sunder
S
Sims-Lucas
Pediatric Heart Lung Center, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Steven H
SH
Abman
D002102:Cadaver; D003937:Diagnosis, Differential; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007150:Immunohistochemistry / Q000379:methods*; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply*; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis*; D011650:Pulmonary Alveoli / Q000002:abnormalities*; D011667:Pulmonary Veins / Q000473:pathology*; D015203:Reproducibility of Results
3-dimensional; 3D; ACD; Alveolar capillary dysplasia; IPSV; Intrapulmonary shunt vessels; MPV; Misalignment of pulmonary veins; PPHN; Persistent pulmonary hypertension of the newborn