Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor.
BACKGROUND
There are numerous causes for intracranial calcification in children. We describe an unusual cause of intracranial calcification in a child, namely, nephrogenic diabetes insipidus (NDI).


METHODS
A 12-year-old boy presented with seizures and developmental delay. MRI of the brain revealed intracranial calcification. Evaluation showed findings suggestive of NDI. The lack of evidence of any other metabolic defect suggests that these calcifications were secondary to NDI. He also had anemia for which he was investigated and diagnosed as thalassemia minor. Detailed literature review failed to reveal any reported association between NDI and thalassemia minor.


CONCLUSIONS
We report this case to emphasize the importance of early diagnosis and treatment of NDI to prevent organic brain damage.
Department of Pediatrics, Lokmanya Tilak Municipal medical college and general hospital, Sion, Mumbai - 400022, India.
Jain
J
Dimple
Jadhav
J
Alka
Gajre
G
Mona
Deshmukh
D
Atul
D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology; D018500:Diabetes Insipidus, Nephrogenic / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000209:etiology; D017086:beta-Thalassemia / Q000150:complications* / Q000175:diagnosis