Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract.
OBJECTIVE
The aim of this preliminary clinical study was to assess if the daily intake of Agaricus blazei Murill (ABM) granulated powder (SSI Co., Ltd., Tokyo, Japan) for 6 months improved the quality of life (QOL) in cancer patients in remission.


METHODS
Open study.


METHODS
Subjects diurnally took 1 (1.8 g; N=23), 2 (3.6 g; N=22), or 3 (5.4 g; N=22) packs/day orally for 6 months.


METHODS
The SF-8 Health Survey questionnaire was used to evaluate the QOL. The differences between the SF-8 baseline scores at the time of entry and 6-months after ABM treatment were evaluated.


RESULTS
The results showed a significant improvement in QOL in both physical and mental components. More specifically, QOL effects of ABM in different genders showed males improved physical components, while females improved only mental components. QOL effects in the different age groups showed that ages 65 and under improved mental components, while ages 66 and older improved physical components. Furthermore, with respect to optimal dose effects of ABM with respect to QOL improvement, two packs per day for 6 months showed improvements in both physical and mental components.


CONCLUSIONS
This preliminary longitudinal clinical study demonstrated that daily intake of ABM appears to improve both physical and mental components based on SF-8 qualimetric analysis.
Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Japan; Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Japan; Department of Clinical Research Medicine, Teikyo University School of Medicine, Japan. Electronic address: satoshi.ohno55@gmail.com.
Satoshi
S
Ohno
Yoshiteru
Y
Sumiyoshi
Katsuyoshi
K
Hashine
Akitomi
A
Shirato
Satoru
S
Kyo
Masaki
M
Inoue
D000328:Adult; D000363:Agaricales; D000364:Agaricus; D000368:Aged; D000529:Complementary Therapies / Q000379:methods*; D019587:Dietary Supplements; D018572:Disease-Free Survival; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000178:diet therapy* / Q000523:psychology; D011788:Quality of Life; D011795:Surveys and Questionnaires
Agaricus blazei Murill; Cancer survivor; Clinical trial; QOL; SF-8