Predictors of endothelial dysfunction in patients with rheumatoid arthritis.
We investigated the predictors of endothelial dysfunction in patients with rheumatoid arthritis (RA) by brachial artery flow-mediated vasodilatation (FMD). The study population included 50 patients with RA and 30 controls. Disease activity score (DAS28) was calculated for patients with RA. An FMD response <7% was accepted as impaired FMD. Brachial artery Doppler study revealed that in patients with RA, FMD% was significantly lower as compared with controls (6.6% ± 3.5% vs 9.7% ± 41%, P = .002). After multivariate logistic regression analysis, erythrocyte sedimentation rate (ESR; OR: 1.086, 95% confidence interval [CI]: 1.012-1.167, P = .023), duration of RA (OR: 1.392, 95% CI: 1.044-1.856, P = .024), and DAS28 (OR: 3.335, 95% CI: 1.067-10.42, P = .038) were independent predictors of impaired FMD in patients with RA. Endothelial function is impaired in patients with RA. Disease duration, DAS28, and ESR indicating active inflammation are independent predictors of impaired FMD in patients with RA.
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey drsarli@yahoo.com.
Bahadir
B
Sarli
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Ahmet Oguz
AO
Baktir
Department of Physical Medicine and Rehabilitation, Kayseri Education and Research Hospital, Kayseri, Turkey.
Mehtap
M
Cebicci
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Yasemin
Y
Dogan
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Melih
M
Demirbas
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Serkan
S
Kurtul
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Hayrettin
H
Saglam
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Mahmut
M
Akpek
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Omer
O
Sahin
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
Huseyin
H
Arinc
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D018608:Ultrasonography, Doppler; D014664:Vasodilation
D015415:Biomarkers; D018836:Inflammation Mediators; D008055:Lipids; D002097:C-Reactive Protein
atherosclerosis; endothelial dysfunction; flow-mediated vasodilatation; inflammation; rheumatoid arthritis