Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination.
Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.
Department of Tumor Immunology; Nijmegen Centre for Molecular Life Sciences; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Nuclear Medicine; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.
Erik Hjg
EH
Aarntzen
Mangala
M
Srinivas
Gerty
G
Schreibelt
Arend
A
Heerschap
Cornelius Ja
CJ
Punt
Carl G
CG
Figdor
Wim J
WJ
Oyen
I Jolanda M
IJ
de Vries
19F MRI; dendritic cell; imaging; immunotherapy; migration