Effect of flunixin meglumine on prostacyclin accumulation in the equine eye.
A study was performed to identify prostacyclin (PGI2) in equine aqueous humor, demonstrate an increase in PGI2 following anterior chamber paracentesis, and determine the effects of subconjunctival injection of flunixin meglumine on PGI2 accumulation. Twenty ponies were found to be normal upon ocular examination and were placed under general anesthesia. Anterior chamber paracentesis was performed in both eyes (right and left); immediately afterward, 25 mg of flunixin meglumine was injected (subconjunctivally) in the left eye. Aqueous paracentesis was performed 1.5 hours later (both eyes). Aqueous humor samples were assayed for 6-keto PGF1alpha, the stable, inactive metabolite of PGI2. Eyes treated with flunixin meglumine contained less 6-keto PGF1alpha than did control eyes.
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
P L
PL
Cooley
R
R
Milvae
R C
RC
Riis
L J
LJ
Laratta
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003002:Clonixin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005123:Eye / Q000187:drug effects* / Q000378:metabolism; D006736:Horses / Q000378:metabolism*; D019152:Paracentesis / Q000662:veterinary*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015121:6-Ketoprostaglandin F1 alpha; C014558:flunixin meglumine; D003002:Clonixin