[Updates on rickets and osteomalacia: biological function of osteocyte and FGF23/klotho system].
Osteocytes are known to synthesize FGF23 which would bind to FGFR1c/klotho complex in proximal renal tubules in kidney, thereby, reducing serum concentration of Pi and the activity of 1α-hydroxylase. Meanwhile, recent studies suggest the possibility that osteocytes might induce osteolysis of lacuna walls. Compact, cortical bone develops well-organized distribution of osteocyte-lacunar canalicular system (OLCS) , which appears to be efficient for osteocytic function. There seems some relation between the geometrical regularity of OLCS and osteocytic regulation of systemic and local mineral balance.
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University, Japan.
Norio
N
Amizuka
Tomoka
T
Hasegawa
Muneteru
M
Sasaki
Tomomaya
T
Yamamoto
Tsuneyuki
T
Yamamoto
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D000090265:Klotho Proteins; D010011:Osteocytes / Q000378:metabolism*; D012279:Rickets / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins