HypoxamiR regulation and function in ischemic cardiovascular diseases.
CONCLUSIONS
MicroRNAs (miRNAs) are deregulated and play a causal role in numerous cardiovascular diseases, including myocardial infarction, coronary artery disease, hypertension, heart failure, stroke, peripheral artery disease, kidney ischemia-reperfusion.


BACKGROUND
One crucial component of ischemic cardiovascular diseases is represented by hypoxia. Indeed, hypoxia is a powerful stimulus regulating the expression of a specific subset of miRNAs, named hypoxia-induced miRNAs (hypoxamiR). These miRNAs are fundamental regulators of the cell responses to decreased oxygen tension. Certain hypoxamiRs seem to have a particularly pervasive role, such as miR-210 that is virtually induced in all ischemic diseases tested so far. However, its specific function may change according to the physiopathological context.


RESULTS
The discovery of HypoxamiR dates back 6 years. Thus, despite a rapid growth in knowledge and attention, a deeper insight of the molecular mechanisms underpinning hypoxamiR regulation and function is needed.


CONCLUSIONS
An extended understanding of the function of hypoxamiR in gene regulatory networks associated with cardiovascular diseases will allow the identification of novel molecular mechanisms of disease and indicate the development of innovative therapeutic approaches.
1 Molecular Cardiology Laboratory , IRCCS-Policlinico San Donato, Milan, Italy .
Simona
S
Greco
Carlo
C
Gaetano
Fabio
F
Martelli
D000818:Animals; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000502:physiology*; D018919:Neovascularization, Physiologic; D018384:Oxidative Stress; D034622:RNA Interference
D035683:MicroRNAs