Autonomic nerve development contributes to prostate cancer progression.
In a significant translational study, Magnon et al. investigated the role that the autonomic nervous system plays in the development and spread of prostate cancer in both mice and human models. The study shows different roles for both branches of the autonomic nervous system, with the sympathetic system promoting early stages of tumorigenesis, and the parasympathetic system promoting cancer dissemination. This information could lead to important new foundations for treatment, therapies and management of prostate cancer.
John
J
Bauman
Kevin
K
McVary
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001341:Autonomic Nervous System / Q000254:growth & development*; D006801:Humans; D008297:Male; D055495:Neurogenesis; D011467:Prostate / Q000294:innervation* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*