Management of bisphosphonate-related osteonecrosis of the jaw with a platelet-rich fibrin membrane: technical report.
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication resulting from the long-term application of bisphosphonates. In most cases, BRONJ occurs after a surgical procedure involving the jawbone. Currently, the management of BRONJ remains controversial, and there is no definitive treatment other than palliative methods. Platelet-rich fibrin (PRF) represents a relatively new biotechnology for the stimulation and acceleration of tissue healing and bone regeneration. This technical note describes the total closure of moderate bone exposure in persistent BRONJ in 2 weeks with a double-layer PRF membrane. PRF may stimulate gingival healing and act as a barrier membrane between the alveolar bone and the oral cavity. PRF may offer a fast, easy, and effective alternative method for the closure of bone exposure in BRONJ.
Fellow, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey. Electronic address: sdksoydan@yahoo.com.
Sıdıka Sinem
SS
Soydan
Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey.
Sina
S
Uckan
D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000188:drug therapy / Q000628:therapy*; D001792:Blood Platelets; D004164:Diphosphonates / Q000627:therapeutic use; D005337:Fibrin / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008567:Membranes, Artificial; D009101:Multiple Myeloma / Q000188:drug therapy; D000077268:Pamidronate; D000077211:Zoledronic Acid
D004164:Diphosphonates; D007093:Imidazoles; D008567:Membranes, Artificial; D000077211:Zoledronic Acid; D005337:Fibrin; D000077268:Pamidronate