Development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications.
The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1:2 and 1:5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1:2 to 1:5 ratios, respectively.
Department of Materials Science and Engineering, The Kroto Research Institute, University of Sheffield, North Campus, Broad Lane, Sheffield S3 7HQ, UK.
Hilal
H
Istanbullu
Sofia
S
Ahmed
Muhammad Ali
MA
Sheraz
Ihtesham ur Rehman
D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000494:pharmacology*
D011140:Polyurethanes; D062367:ortho-Aminobenzoates; C009500:tolfenamic acid