Intracranial pulsatility is associated with regional brain volume in elderly individuals.
Excessive intracranial pulsatility is thought to damage the cerebral microcirculation, causing cognitive decline in elderly individuals. We investigated relationships between brain structure and measures related to intracranial pulsatility among healthy elderly. Thirty-seven stroke-free, non-demented individuals (62-82 years of age) were included. We assessed brain structure, invasively measured cerebrospinal fluid (CSF) pulse pressure, and magnetic resonance-quantified arterial and CSF flow pulsatility, as well as arterial pulse pressure. Using both multivariate partial least squares and ordinary regression analyses, we identified a significant pattern of negative relationships between the volume of several brain regions and measures of intracranial pulsatility. The strongest relationships concerned the temporal lobe cortex and hippocampus. These findings were also coherent with observations of positive relationships between intracranial pulsatility and ventricular volume. In conclusion, elderly subjects with high intracranial pulsatility display smaller brain volume and larger ventricles, supporting the notion that excessive cerebral arterial pulsatility harms the brain. This calls for research investigating altered intracranial cardiac-related pulsatile stress as a potential risk factor that may cause or worsen the prognosis in subjects developing cognitive impairment and dementia.
Department of Radiation Sciences, Umeå University, Umeå, Sweden. Electronic address: Anders.Wahlin@radfys.umu.se.
Anders
A
Wåhlin
Khalid
K
Ambarki
Richard
R
Birgander
Jan
J
Malm
Anders
A
Eklund
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D009929:Organ Size; D011673:Pulsatile Flow / Q000502:physiology*; D012307:Risk Factors
Aging; Arterial pulsatility; Brain volume; Cerebral blood flow; Cerebrospinal fluid