Spectroscopic and biological approach in the characterization of a novel 14-membered [N4] macrocyclic ligand and its palladium(II), platinum(II), ruthenium(III) and iridium(III) complexes.
A novel, tetradentate nitrogen donor [N4] macrocyclic ligand, i.e. 3,5,14,16-tetramethyl-2,6,13,17-tetraazatricyclo[12,0,0(7-12)] cosa-1(22),2,5,7,9,11,13,16,18,20-decaene(L), has been synthesized and characterized by elemental analyses, IR, Mass, and (1)H NMR spectral studies. Complexes of Pd(II), Pt(II), Ru(III) and Ir(III) have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements, IR, Mass, electronic spectral and thermal studies. On the basis of molar conductance the complexes may be formulated as [PdL]Cl2, [PtL]Cl2, [Ru(L)Cl2]Cl and [Ir(L)Cl2]Cl. The complexes are insoluble in most common solvents, including water, ethanol, carbon tetrachloride and acetonitrile, but soluble in DMF/DMSO. The value of magnetic moment indicates that all the complexes are diamagnetic except Ru(III) complex which shows magnetic moment corresponding to one unpaired electron. The magnetic moment of Ru(III) complex is 1.73 B.M. at room temperature. The antimicrobial activities of ligand and its complexes have been screened in vitro, as growth inhibiting agents. The antifungal and antibacterial screening were carried out using Food Poison and Disc Diffusion Method against plant pathogenic fungi and bacteria Alternaria porri, Fusarium oxysporum, Xanthomonas compestris and Pseudomonas aeruginosa respectively. The compounds were dissolved in DMSO to get the required solutions. The required medium used for these activities was PDA and nutrient agar.
Department of Chemistry, Zakir Husain College (University of Delhi), J.L. Nehru Marg, New Delhi 110002, India. Electronic address: soniteotia81@gmail.com.
Soni
S
Rani
Sumit
S
Kumar
Sulekh
S
Chandra
D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D004553:Electric Conductivity; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D007495:Iridium / Q000494:pharmacology; D008024:Ligands; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D019216:Metals, Heavy / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010165:Palladium / Q000494:pharmacology; D010984:Platinum / Q000494:pharmacology; D012428:Ruthenium / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013696:Temperature
D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D019216:Metals, Heavy; D007495:Iridium; D010984:Platinum; D010165:Palladium; D012428:Ruthenium
Antimicrobial activities; Characterization; Metal complexes; Tetradentate macrocyclic; Thermal studies