Functional decline in older patients with cancer receiving first-line chemotherapy.
OBJECTIVE
To determine factors associated with early functional decline during first-line chemotherapy in older patients.


METHODS
Patients age ≥ 70 years receiving first-line chemotherapy for cancer were prospectively considered for inclusion across 12 centers in France. Functional decline was defined as a decrease of ≥ 0.5 points on the Activities of Daily Living (ADL) scale between the beginning of chemotherapy and the second cycle. Factors associated with functional decline were sought from pretreatment abbreviated comprehensive geriatric assessment, including ADL, Instrumental ADL (IADL), Mini-Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS15), and Timed Get Up and Go (GUG) test, and from comorbidities (Cumulative Illness Rating Scale-Geriatrics), MAX2 index, and baseline biologic and clinical information.


RESULTS
Of 364 included patients, 50 experienced functional decline (16.7%; median, 0.5 points). Abnormal preadmission performance status, IADL, GDS15, MMSE, GUG, and MNA were associated with increased likelihood of functional decline (univariate analysis). In the multivariate model adjusted for baseline ADL and MAX2 index, high baseline GDS (odds ratio [OR], 2.16; 95% CI, 1.09 to 4.30; P = .03) and low IADL scores (OR, 2.87; 95% CI, 1.06 to 7.79; P = .04) were independently associated with increased risk of functional decline.


CONCLUSIONS
Our results outline associations between baseline depression, instrumental dependencies, and early functional decline during chemotherapy for older patients. ADL should be sequentially evaluated early during treatment. Baseline evaluation of GDS15 and IADL may be proposed to anticipate this event.
Stéphanie Hoppe, Marianne Fonck, Laurent Hoppenreys, Cécile Mertens, Nadine Houédé, Carine A. Bellera, Anne Floquet, Marie-Noëlle Fabry, Camille Chakiba, Simone Mathoulin-Pélissier, and Pierre Soubeyran, Institut Bergonié; Muriel Rainfray, Jean-Frédéric Blanc, Cécile Mertens, and Alain Ravaud, Centre Hospitalier Universitaire; Muriel Rainfray, Christèle Blanc-Bisson, Alain Ravaud, Simone Mathoulin-Pélissier, and Pierre Soubeyran, University of Bordeaux, Bordeaux; Joël Ceccaldi, Centre Hospitalier, Libourne; Yves Imbert and Luc Vogt, Centre Hospitalier, Agen; Laurent Cany, Clinique Francheville, Périgueux; and Jérôme Dauba, Centre Hospitalier, Mont de Marsan, France.
Stéphanie
S
Hoppe
Muriel
M
Rainfray
Marianne
M
Fonck
Laurent
L
Hoppenreys
Jean-Frédéric
JF
Blanc
Joël
J
Ceccaldi
Cécile
C
Mertens
Christèle
C
Blanc-Bisson
Yves
Y
Imbert
Laurent
L
Cany
Luc
L
Vogt
Jérôme
J
Dauba
Nadine
N
Houédé
Carine A
CA
Bellera
Anne
A
Floquet
Marie-Noëlle
MN
Fabry
Alain
A
Ravaud
Camille
C
Chakiba
Simone
S
Mathoulin-Pélissier
Pierre
P
Soubeyran
D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003863:Depression / Q000150:complications*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology*; D009483:Neuropsychological Tests
D000970:Antineoplastic Agents