Influence of endothelin-1 and nitric oxide on left ventricular remodelling in patients on peritoneal dialysis.
BACKGROUND
Left ventricular hypertrophy is the most common structural cardiac alteration in chronic dialysis patients. The aim of this study was to determine the possible association of endotelin-1 (ET-1) and nitric oxide (NO) with parameters of echocardiography in order to assess their participation in left ventricular (LV) remodeling in patients on peritoneal dialysis (PD).


METHODS
This prospective longitudinal study included 40 PD patients. Serum levels of ET-1 and NO baseline and after 12 months of PD treatment were measured and compared with echocardiography parameters done at the same time of PD treatment. Linear regression analysis was used to detect independent correlations of variables.


RESULTS
Mean ET-1 serum concentration decreased significantly after 12 months of PD treatment compared to baseline values (p < 0.01). NO serum concentration increased significantly 12 months after treatment compared to baseline values (p < 0.01). Left ventricular hypertrophy (LVH) was observed in 72.5% of patients at baseline with significant reduction in LV mass index after 12 months of PD treatment (p < 0.001). On linear regression analysis serum concentration of ET-1 was independent predictors of LV mass index, as well as NO at the end of observed period.


CONCLUSIONS
According to our data ET-1 and NO are independently related to the process of left ventricular remodeling in PD patients.
Clinic for Nephrology, Clinical Center of University of Sarajevo , Sarajevo , Bosnia and Herzegovina and.
Damir
D
Rebic
Senija
S
Rasic
Velma
V
Rebic
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D012044:Regression Analysis; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000502:physiology*
D015415:Biomarkers; D019332:Endothelin-1; D009569:Nitric Oxide