Extramedullary chronic lymphocytic leukemia: systematic analysis of cases reported between 1975 and 2012.
The prognostic significance of extra-medullary chronic lymphocytic leukemia (EM-CLL) is unknown. We conducted a Medline database systematic search analyzing English language articles published between 1975 and 2012 identifying 192 cases. Patients with EM-CLL were more commonly treated than not (p < .001). Skin and central nervous system (CNS) were the most commonly reported sites of organ involvement. Survival after diagnosis of EM-CLL appeared to depend on the site of EM involvement. Prospective evaluation and further studies of EM-CLL are warranted.
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, United States.
Megan
M
Ratterman
Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, United States.
Kimberly
K
Kruczek
James R. & Helen D. Russell Institute for Research & Innovation, Advocate Lutheran General Hospital, Park Ridge, IL, United States.
Suela
S
Sulo
Division of Hematology, Mayo Clinic, Rochester, MN, United States.
Tait D
TD
Shanafelt
Division of Hematology, Mayo Clinic, Rochester, MN, United States.
Neil E
NE
Kay
Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States. Electronic address: cnabhan@medicine.bsd.uchicago.edu.
Chadi
C
Nabhan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D016206:Databases, Bibliographic; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D008297:Male; D011379:Prognosis; D012867:Skin / Q000473:pathology; D016019:Survival Analysis
CLL; Chronic lymphocytic leukemia; Extra-medullary; Prognosis