[Study the effects of neuroplasticity on major depression disorder in rTMS combined with antidepressant treatments].
OBJECTIVE
To explore the effects of neuroplasticity on major depression disorder (MDD) with event related potentials (ERPs) of mismatch negativity (MMN) and sensory gating potentials P50 for repetitive transcranial magnetic stimulation (rTMS) combined with antidepressant treatments.


METHODS
A total of 159 patients with MDD randomly divided into two groups: 75 patients in group A was administrated rTMS treatment for 2 weeks (15 days), and continues to give antidepressant of selective serotonin reuptake inhibitor (SSRI) regularly. 84 patients in group B was consistently administered the similar antidepressant. The 24-item Hamilton Depression Scale (HAMD-24), MMN latency, S1-P50 amplitude, S2-P50 amplitude and S2-P50/S1-P50 amplitude ratio, and the percentages of abnormal P50 (S2-P50/S1-P50 > or = 0.5) were assessed and measured before treatment, at the 2nd and the 10th weekend after treatment in two treatment groups. Meanwhile, 90 normal control cases was set up as control group (group C). Results At 2th and 10th week after treatment, the HAMD-24 scores were reduced remarkably than those before treatment in group A and B (P < 0.001), and the scores in group A was lower than that in group B (P < 0.001). MMN latencies and S-P50 amplitudes after treatment in group A were significant shorter and lower than those before treatment in group A and after treatment in group B (P < 0.05) (except for intergroup comparison of S2-P50, amplitude after treatment weeks). No significant difference was found in S2-P50/S1-P50 ratio ( except for after treatment 2 weeks ) and percentage of abnormal P50 between group A after treatment and group C (P > 0.05). There were no statistical significance difference of ERPs between after treatment 2 weeks and 10 weeks in group A (P > 0.05). No statistical differences of ERPs between before and after treatment in group B (P > 0.05) was observed.


CONCLUSIONS
rTMS combined with antidepressant therapy was superior to single antidepressant treatment, and marked improved automatic processing and sensory gating of the brain senior functional electrical physiological index. rTMS might induce effects of long-term potentiation/long-term depression like plasticity on brain, and keep brain function in a dynamic stability and balance. MMN and P50 maybe become neuroplasticity index reflecting relevant the brain senior function.
West China School of Clinical Medicine, Sichuan University, Chengdu 610041, China.
Bo
B
Zheng
Zhong
Z
Zheng
Ke
K
Zou
Ting-Ting
TT
Yan
Li-Ling
LL
Mo
Zhe-Si
ZS
Chen
Xue-Li
XL
Sun
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000628:therapy*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult
D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors