cis-clerodane diterpenes from the liverwort Scapania ciliata.
Chemical investigation of the Chinese liverwort Scapania ciliata led to the isolation of four new cis-clerodane lactones, named ciliatolides A-D (1-4, resp.), among which compound 1 was found to be a tetranorclerodanoid. Their structures were determined by extensive analysis of spectroscopic data, and, in the case of compound 1, together with a single-crystal X-ray diffraction analysis. The absolute configurations were established by analysis of the CD spectra and by quantum-chemical CD calculations. The cytotoxicities of compounds 1-4 were preliminarily tested against the PC3 and MCF-7 cell lines.
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China, (phone: +86-531-88382012; fax: +86-531-88382019).
Na
N
Liu
Rong-Xiu
RX
Zhu
Song
S
Wang
Jiao-Zhen
JZ
Zhang
Zhao-Min
ZM
Lin
Rui-Juan
RJ
Li
Hong-Xiang
HX
Lou
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D035926:Hepatophyta / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D061986:MCF-7 Cells; D008968:Molecular Conformation
D045785:Diterpenes, Clerodane
Clerodane; Cytotoxic activity; Diterpenoids; Liverworts; Scapania ciliata