An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions.
Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China. wenweilin@ntnu.edu.tw.
Yi-Ling
YL
Tsai
Yu-Shiou
YS
Fan
Chia-Jui
CJ
Lee
Chan-Hui
CH
Huang
Utpal
U
Das
Wenwei
W
Lin
D000215:Acylation; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D010080:Oxazoles