Emergence of a strain of methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin 7 months after treatment with glycopeptide antibiotics.
This case report describes a methicillin-resistant Staphylococcus aureus isolated repeatedly from the blood of a patient with community-acquired endocarditis who developed a four-fold increase in the minimal inhibitory concentration of vancomycin and daptomycin 7 months after his last exposure to glycopeptide antibiotics. This is contrary to the expected situation in which antimicrobial resistance tends to decrease after a patient is no longer exposed to vancomycin.
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Cheng Len
CL
Sy
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; National Yang-Ming University, Taipei, Taiwan.
Susan Shin-Jung
SS
Lee
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; National Yang-Ming University, Taipei, Taiwan.
Kuan-Sheng
KS
Wu
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; National Yang-Ming University, Taipei, Taiwan.
Hung-Chin
HC
Tsai
Section of Infectious Diseases, Shuang-Ho Hospital, Taipei Medical University and School of Medicine, Taipei Medical University, Taipei, Taiwan.
Yung-Ching
YC
Liu
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; National Yang-Ming University, Taipei, Taiwan. Electronic address: yschen@vghks.gov.tw.
Yao-Shen
YS
Chen
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006020:Glycopeptides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D006020:Glycopeptides
Daptomycin; Glycopeptide; Resistance; Staphylococcus aureus; Vancomycin