Human Papilloma Virus: Prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma.
OBJECTIVE
To evaluate the prevalence, distribution and association of HPV with histological pattern of worse prognosis of penile cancer, in order to evaluate its predictive value of inguinal metastasis, as well as evaluation of other previous reported prognostic factors.


METHODS
Tumor samples of 82 patients with penile carcinoma were tested in order to establish the prevalence and distribution of genotypic HPV using PCR. HPV status was correlated to histopathological factors and the presence of inguinal mestastasis. The influence of several histological characteristics was also correlated to inguinal disease-free survival.


RESULTS
Follow-up varied from 1 to 71 months (median 22 months). HPV DNA was identified in 60.9% of sample, with higher prevalence of types 11 and 6 (64% and 32%, respectively). There was no significant correlation of the histological characteristics of worse prognosis of penile cancer with HPV status. Inguinal disease-free survival in 5 years did also not show HPV status influence (p = 0.45). The only independent pathologic factors of inguinal metastasis were: stage T ≥ T1b-T4 (p = 0.02), lymphovascular invasion (p = 0.04) and infiltrative invasion (p = 0.03).


CONCLUSIONS
HPV status and distribution had shown no correlation with worse prognosis of histological aspects, or predictive value for lymphatic metastasis in penile carcinoma.
Urology Department, Hospital Ophyr Loyola, Belem, PA, Brazil.
Aluizio Gonçalves da
AG
Fonseca
Fernando Augusto
FA
Soares
Rommel Rodriguez
RR
Burbano
Rodrigo Vellasco
RV
Silvestre
Luis Otávio Amaral Duarte
LO
Pinto
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002277:Carcinoma / Q000473:pathology / Q000556:secondary / Q000821:virology*; D018572:Disease-Free Survival; D006801:Humans; D007264:Inguinal Canal; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D010412:Penile Neoplasms / Q000473:pathology* / Q000821:virology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult