The effect of silver nitrate pleurodesis after a failed thoracoscopic talc poudrage.
BACKGROUND
Chemical pleurodesis is the procedure of choice in the management of recurrent malignant pleural effusions (MPE). Talc is probably the most effective sclerosant, with a success rate of 80%. The aim of this study is to demonstrate the effectiveness of silver nitrate solution (SNS) pleurodesis after an unsuccessful thoracoscopic talc poudrage.


METHODS
Between 2011 and 2013 one hundred and nine patients with unilateral MPE underwent thoracoscopic talc poudrage. Seventeen patients who did not obtain a successful pleurodesis via thoracoscopic procedure were considered for an SNS slurry. The pleural injectate consisted of 100 mL 1% SNS with 10 mL of lidocaine (100 mg/5 mL). The SNS procedure was undertaken once and repeated with the same dose in 5 patients.


RESULTS
The duration of follow-up period was 30 days. Subjective pain was low and the same before and after SNS procedure (P value = NS). The mean daily fluid drainage was statistically different (P = 0.001) comparing values before (597.0 ± 122.8 mL) and after SNS procedure (109.1 ± 22.3 mL). After 30 days from SNS procedure recurrence of pleural effusion was observed in 2 patients (11%).


CONCLUSIONS
The present study demonstrates that SNS is an effective agent for producing pleurodesis after a failed thoracoscopic talc poudrage.
Division of Thoracic Surgery, "G. Mazzini" Hospital of Teramo, Faculty of Medicine and Surgery, University of L'Aquila, Piazza Italia 1, 64100 Teramo, Italy.
Cecilia
C
Menna
Claudio
C
Andreetti
Mohsen
M
Ibrahim
Giulio
G
Maurizi
Camilla
C
Poggi
Rocco
R
Barile
Francesco
F
Cassiano
Erino A
EA
Rendina
D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000628:therapy*; D018700:Pleurodesis; D013902:Radiography, Thoracic; D012835:Silver Nitrate / Q000008:administration & dosage* / Q000627:therapeutic use*; D013627:Talc / Q000008:administration & dosage* / Q000627:therapeutic use*; D013906:Thoracoscopy; D017211:Treatment Failure
D013627:Talc; D012835:Silver Nitrate