A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population.
OBJECTIVE
Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes.


METHODS
With multiplex SNaPshot method, we genotyped TOX3 rs3803662 in 880 gastric patients with surgical resection. The association between genotype and survival outcomes was performed by the Kaplan-Meier method, Cox regression analysis models and the log-rank test.


RESULTS
There was no association in the analyses of rs3803662 and survival of gastric cancer. However, the stratified analysis by histology showed that rs3803662 CT/TT genotype was associated with a significantly better survival for diffuse-type gastric cancer (log-rank p = 0.030, hazard ratio [HR]  = 0.67, 95% confidence interval [CI]  = 0.46-0.96), than the CC genotype. In addition, this favorable effect was especially obvious among gastric cancer patients with tumor size >5 cm, T3 and T4 depth of invasion, lymph node metastasis, no drinking, no distant metastasis, no chemotherapy and gastric cardia cancer.


CONCLUSIONS
TOX3 rs3803662 might play an important role in the prognostic outcome and treatment of gastric cancer, especially perhaps further help in explaining the reduced risk of death associated with diffuse-type gastric cancer.
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P. R. China ; Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China.
Xiaojing
X
Zhang
Haixia
H
Zhu
Xiaomin
X
Wu
Meilin
M
Wang
Dongying
D
Gu
Weida
W
Gong
Zhi
Z
Xu
Yongfei
Y
Tan
Yongling
Y
Gong
Jianwei
J
Zhou
Cuiju
C
Tang
Na
N
Tong
Jinfei
J
Chen
Zhengdong
Z
Zhang
D051017:Apoptosis Regulatory Proteins; D044466:Asian People / Q000235:genetics; D005260:Female; D005838:Genotype; D006609:High Mobility Group Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D015534:Trans-Activators
D051017:Apoptosis Regulatory Proteins; D006609:High Mobility Group Proteins; D011980:Receptors, Progesterone; C521752:TOX3 protein, human; D015534:Trans-Activators