Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy.
BACKGROUND
Spine stereotactic body radiotherapy (SBRT) is increasingly being applied to the postoperative spine metastases patient. Our aim was to identify clinical and dosimetric predictors of local control (LC) and survival.


METHODS
Eighty patients treated between October 2008 and February 2012 with postoperative SBRT were identified from our prospective database and retrospectively reviewed.


RESULTS
The median follow-up was 8.3 months. Thirty-five patients (44%) were treated with 18-26 Gy in 1 or 2 fractions, and 45 patients (56%) with 18-40 Gy in 3-5 fractions. Twenty-one local failures (26%) were observed, and the 1-year LC and overall survival (OS) rates were 84% and 64%, respectively. The most common site of failure was within the epidural space (15/21, 71%). Multivariate proportional hazards analysis identified systemic therapy post-SBRT as the only significant predictor of OS (P = .02) and treatment with 18-26 Gy/1 or 2 fractions (P = .02) and a postoperative epidural disease grade of 0 or 1 (0, no epidural disease; 1, epidural disease that compresses dura only, P = .003) as significant predictors of LC. Subset analysis for only those patients (n = 48/80) with high-grade preoperative epidural disease (cord deformed) indicated significantly greater LC rates when surgically downgraded to 0/1 vs 2 (P = .0009).


CONCLUSIONS
Postoperative SBRT with high total doses ranging from 18 to 26 Gy delivered in 1-2 fractions predicted superior LC, as did postoperative epidural grade.
Corresponding Author: Dr Arjun Sahgal, MD, Department of Radiation Oncology, Sunnybrook Health Sciences Centre and Princess Margaret Cancer Centre, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada. arjun.sahgal@rmp.uhn.on.ca.
Ameen
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Al-Omair
Laura
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Masucci
Laurence
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Masson-Cote
Mikki
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Campbell
Eshetu G
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Atenafu
Amy
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Parent
Daniel
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Letourneau
Eugene
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Yu
Raja
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Rampersaud
Eric
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Massicotte
Stephen
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Lewis
Albert
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Yee
Isabelle
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Thibault
Michael G
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Fehlings
Arjun
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Sahgal
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015174:Epidural Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D016634:Radiosurgery; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000556:secondary / Q000601:surgery*; D015996:Survival Rate; D055815:Young Adult
postoperative radiation; spinal cord compression; spine metastases; spine radiosurgery; spine stereotactic body radiotherapy