Does ethnicity moderate dementia's biomarkers?
We have used structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ") from that which is unrelated to a dementing process. Our approach results in a relatively "error-free" continuous variable that can serve as a dementia-specific phenotype. In this study, we associate δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. Independent of covariates, δ is associated significantly with 12 serum biomarkers. These associations appear to be specific to non-Hispanic white participants.
Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA; Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA; Department of Family and Community Medicine, The University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans' Health System, Audie L. Murphy Division GRECC, San Antonio, TX, USA. Electronic address: royall@uthscsa.edu.
Donald R
DR
Royall
Raymond F
RF
Palmer
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D003071:Cognition / Q000502:physiology*; D015331:Cohort Studies; D003704:Dementia / Q000097:blood / Q000208:ethnology* / Q000523:psychology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D012044:Regression Analysis; D014705:Verbal Behavior / Q000502:physiology*
D015415:Biomarkers
Aging; Cognition; Dementia; Functional Status; g