Through the dark continent: African trypanosome development in the tsetse fly.
African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and nagana in cattle. These parasites are almost exclusively transmitted by the bite of the tsetse fly. In this review, we describe and compare the three developmental programs of the main trypanosome species impacting human and animal health, with focus on the most recent observations. From here, some reflections are made on research issues concerning trypanosome developmental biology in the tsetse fly that are to be addressed in the future.
Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France. rotureau@pasteur.fr
Brice
B
Rotureau
Jan
J
Van Den Abbeele
D000349:Africa; D000818:Animals; D002417:Cattle; D006801:Humans; D010274:Parasitology / Q000639:trends; D014345:Trypanosoma / Q000254:growth & development*; D014370:Tsetse Flies / Q000469:parasitology*
African trypanosomes; development; parasite cycle; tsetse fly; vector