Fast enantioseparation by HPLC on a modified carbon nanotube monolithic stationary phase with a pyrenyl aminoglycoside derivative.
This work deals with the development of a carbon nanotube (CNT) monolithic column coated with a pyrenyl derivative as chiral selector. For this, a solution of pyrenyl neomycine A was pumping through a monolithic CNT column previously developed by our group. This coating was stable against the desorption for months when aqueous mobile phases were used. This column was applied to the chiral separation of underivatized amino acids. As well, ultra fast separations in the range of seconds were achieved using high flow-rates.
Univ Franche-Comté, F-25000 Besançon, France; CHU Besançon, Pôle Pharmaceutique, F-25000 Besançon, France; UFR SMP Besançon, EA4662 Nanomedecine/Pôle Chimie Analytique Bioanalytique et Physique, F-25000 Besançon, France. Electronic address: yves.guillaume@univ-fcomte.fr.
Yves Claude
YC
Guillaume
Claire
C
André
D000596:Amino Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D005601:Framycetin / Q000737:chemistry*; D037742:Nanotubes, Carbon; D011721:Pyrenes / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D037742:Nanotubes, Carbon; D011721:Pyrenes; D005601:Framycetin; C488396:neamine
Carbon nanotube; Enantioseparation; Pyrenyl aminoglycoside