Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751.
Three new alkaloids, phomapyrrolidones A-C (1-3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.
Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona , 250 E. Valencia Road, Tucson, Arizona 85706, United States.
E M Kithsiri
EM
Wijeratne
Hongping
H
He
Scott G
SG
Franzblau
Angela M
AM
Hoffman
A A Leslie
AA
Gunatilaka
D029041:Actinidiaceae / Q000382:microbiology*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008297:Male; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013388:Succinimides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014709:Vero Cells
D000470:Alkaloids; D000995:Antitubercular Agents; D013388:Succinimides; C585304:phomapyrrolidone A; C585302:phomapyrrolidone B; C585303:phomapyrrolidone C