A case of oligodendroglioma with prominent neuronal differentiation.
We report a case of oligodendroglioma showing marked neuronal differentiation, which arose in the right frontal lobe of a 46-year-old woman. The resected tumor was composed of a mixture of oligodendroglioma, gangliocytoma, and neurocytoma areas with predominance of gangliocytoma-like areas. The oligodendroglioma areas showed immunoreactivity for Olig2 and mutant isocitrate dehydrogenase 1 protein, whereas the gangliocytoma and neurocytoma areas were positive for synaptophysin and NeuN. Ki-67 labeling index was approximately 5% to 10% in the oligodendroglioma areas. Molecular cytogenetic analyses demonstrated chromosomal losses of 1p and 19q and a mutation of isocitrate dehydrogenase 1 (G395A, R132H) in both the oligodendroglioma and gangliocytoma areas. These data suggest that this tumor is an oligodendroglioma associated with prominent neuronal differentiation. There seems to be a close relationship between oligodendroglial progenitor cells and neuronal cells.
Department of Diagnostic Pathology, Tokushima Prefectural Central Hospital, Tokushima 770-8539, Japan. Electronic address: thirose@tph.gr.jp.
Takanori
T
Hirose
Sumihito
S
Nobusawa
Yoichi
Y
Nakazato
Atsushi
A
Sasaki
D034961:Antigens, Nuclear / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D005260:Female; D005729:Ganglioneuroma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018306:Neurocytoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D019635:Neurosurgical Procedures; D000076104:Oligodendrocyte Transcription Factor 2; D009837:Oligodendroglioma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016708:Synaptophysin / Q000378:metabolism
D034961:Antigens, Nuclear; D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D007521:Isocitrate Dehydrogenase; D019394:Ki-67 Antigen; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; D016708:Synaptophysin; C405708:OLIG2 protein, human; C506808:neuronal nuclear antigen NeuN, human
Gangliocytoma; IDH1; Neurocytoma; Neuronal differentiation; Oligodendroglioma