Invading one step at a time: the role of invadopodia in tumor metastasis.
The ability to degrade extracellular matrix is critical for tumor cells to invade and metastasize. Recent studies show that tumor cells use specialized actin-based membrane protrusions termed invadopodia to perform matrix degradation. Invadopodia provide an elegant way for tumor cells to precisely couple focal matrix degradation with directional movement. Here we discuss several key components and regulators of invadopodia that have been uniquely implicated in tumor invasion and metastasis. Furthermore, we discuss existing and new therapeutic opportunities to target invadopodia for anti-metastasis treatment.
Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
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Paz
1] Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA [2] Biomedical Sciences Program, University of California, San Diego, La Jolla, CA, USA.
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Pathak
1] Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA [2] Biomedical Sciences Program, University of California, San Diego, La Jolla, CA, USA [3] Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
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Yang
D051722:ADAM Proteins / Q000378:metabolism; D000818:Animals; D022081:Cell Surface Extensions / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
D051722:ADAM Proteins; D053511:Matrix Metalloproteinase 14