The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila.
The olfactory response of the vinegar fly Drosophila melanogaster to food odor is modulated by starvation. Here we show that this modulation is not restricted to food odors and their detecting sensory neurons but rather increases the behavioral response to odors as different as food odors, repellents and pheromones. The increased behavioral responsiveness is paralleled by an increased physiological sensitivity of sensory neurons regardless whether they express olfactory or ionotropic receptors and regardless whether they are housed in basiconic, coeloconic, or trichoid sensilla. Silencing several genes that become up-regulated under starvation confirmed the involvement of the short neuropeptide f receptor in the starvation effect. In addition it revealed that the CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications.
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07749 Jena, Germany.
Abu
A
Farhan
Jyotasana
J
Gulati
Ewald
E
Groβe-Wilde
Heiko
H
Vogel
Bill S
BS
Hansson
Markus
M
Knaden
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects; D017344:Genes, Insect; D009479:Neuropeptides / Q000494:pharmacology; D018034:Olfactory Receptor Neurons / Q000187:drug effects / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D018035:Receptors, Odorant / Q000235:genetics / Q000378:metabolism*; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D013217:Starvation / Q000503:physiopathology*
C555821:CCHa1-R protein, Drosophila; D029721:Drosophila Proteins; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; D018035:Receptors, Odorant