Arterial stiffness/central hemodynamics, renal function, and development of hypertension over the short term.
OBJECTIVE
We examined the following: whether the estimated glomerular filtration rate calculated from the serum cystatin C levels (eGFRcys) and the brachial-ankle pulse wave velocity (baPWV) might be independent predictors of the development of hypertension over the short term, without any interaction; whether the baPWV may be directly associated with the development of hypertension without the mediation of the arterial stiffness-related acceleration of renal functional decline; whether the second peak of the radial pressure waveform (SP2) might also be a significant independent predictor of the development of hypertension.


METHODS
In 1229 middle-aged normotensive Japanese men with preserved renal function, the baPWV, SP2 and eGFRcys were measured at the baseline and at the end of the 3-year study period.


RESULTS
Hypertension was detected at the end of the 3-year study period in 127 men. The logistic regression analysis with adjustments demonstrated significant independent odds ratios of the baPWV and eGFRcys for the presence of hypertension at the end of the 3-year study period, without any interaction. When entered simultaneously in this model, the SP2 also showed a significant odds ratio. General linear model analysis revealed that none of the baPWV or SP2 measured at the baseline was related to the renal function assessed at the end of the 3-year study period.


CONCLUSIONS
The mechanisms underlying the association between arterial stiffness/central hemodynamics and the short-term development of hypertension appear to differ from those underlying the association between kidney function and the short-term development of hypertension.
aSecond Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan bUniversity of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Hirofumi
H
Tomiyama
Raymond R
RR
Townsend
Chisa
C
Matsumoto
Kazutaka
K
Kimura
Mari
M
Odaira
Masanobu
M
Yoshida
Kazuki
K
Shiina
Akira
A
Yamashina
D000328:Adult; D000428:Alcohol Drinking; D001795:Blood Pressure Determination; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007564:Japan; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness