Tumor progression and transformation of low-grade glial tumors  associated with pregnancy.
Brain tumor growth or progression has been shown to occur in low-grade glial tumors and meningiomas. While progression has been documented in this population, transformation to a more aggressive high-grade glial tumor that can lead to increased morbidity and mortality has not been identified. In this case series, we document transformation from low-grade gliomas to high-grade gliomas (WHO grade III and IV) in young women during pregnancy. We further discuss the possible etiologies of this phenomenon.
Mariza
M
Daras
Christina
C
Cone
Katherine B
KB
Peters
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D013997:Time Factors