In vitro susceptibility of Mycobacterium tuberculosis to trimethoprim and sulfonamides in France.
Five type strains and 55 Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. Two M. canettii isolates uniquely yielded silent mutations C156 → T and G238 → C in the folP1 gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.
Fédération de Microbiologie and Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS-6236, Institut Hospitalier Universitaire Méditerranée Infection, Aix-Marseille-Université, Marseille, France.
Sirwan Muhammed
SM
Ameen
Michel
M
Drancourt
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005602:France; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013449:Sulfonamides / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D014295:Trimethoprim