Efficacy of exogenous surfactant during conventional and high-frequency oscillatory ventilation in preterm infants with RDS.
BACKGROUND
The immediate effects of exogenous surfactant on lung volume and hemodynamics in preterm infants have been poorly studied.


METHODS
Lung volume, SpO2, perfusion index, regional SO2, transcutaneous partial pressure of CO2 were simultaneously monitored and recorded ten minutes after surfactant tracheal instillation in elective HFOV ventilated preterm infants with RDS.


RESULTS
Despite a reduction in gas exchange during the first 5 minutes post surfactant instillation, most likely dependent on airway obstruction, lung volume increases rapidly in HFOV preterm infants with RDS. After 5 minutes from administration of surfactant, lung volume, gas exchange and PI reach stable values and CDP can be safely reduced.
Department of Pediatrics, Division of Neonatology, Università Cattolica del Sacro Cuore, Rome, Italy. vento@rm.unicatt.it
Giovanni
G
Vento
Milena
M
Tana
Chiara
C
Tirone
Claudia
C
Aurilia
Alessandra
A
Lio
Sarah
S
Perelli
Cinzia
C
Ricci
Costantino
C
Romagnoli
D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008176:Lung Volume Measurements; D011659:Pulmonary Gas Exchange; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
D011663:Pulmonary Surfactants