Impaired prefrontal gamma band synchrony in autism spectrum disorders during gaze cueing.
Orienting to eye gaze is a vital social skill that is absent or developmentally delayed in autism spectrum disorders (ASD). Neural synchrony in the gamma frequency band is believed to be involved in perceptual and cognitive functions such as eye-gaze processing, and has been found to be abnormal in ASD. The current study used magnetoencephalography to measure neural synchrony in the gamma frequency band in neurotypicals (n=8) and individuals with ASD (n=10) while performing a directional eye-gaze processing task. Results support impaired generation of neural synchrony in the gamma frequency band during eye-gaze processing in ASD. Impaired gamma oscillatory activity in the prefrontal cortex may be associated with impairments in social cognitive functions such as eye-gaze processing in ASD.
Department of Psychology, Mark Jefferson Science Complex, Eastern Michigan University, Ypsilanti, Michigan, USA.
Annette E
AE
Richard
Renee R
RR
Lajiness-O'Neill
Susan M
SM
Bowyer
D000293:Adolescent; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D003463:Cues; D004569:Electroencephalography; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012919:Social Behavior; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult