Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units.
A highly efficient [4 + 2] annulation route to polysubstituted indolizines is described employing a domino Knoevenagel condensation/intramolecular aldol cyclization process as a key step. Construction of pyridine rings in indolizine skeleton was rapidly achieved from several pyrrole-2-carboxaldehydes in good to excellent yields, leading to indolizines with various substituents at the 5, 6, and 7 positions depending on the reacting active methylene partners.
College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University , 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
Myungock
M
Kim
Youngeun
Y
Jung
Ikyon
I
Kim
D002384:Catalysis; D003500:Cyclization; D007212:Indolizines / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
D007212:Indolizines; D011725:Pyridines; C035094:indolizine