A breath of fresh aire.
The origin and function of extrathymic Aire-expressing cells (eTACs) is incompletely defined. In this issue of Immunity, Gardner et al. (2013) show that eTACs are a distinct tolerogenic cell population that functionally inactivates CD4⁺ T cells to induce peripheral tolerance.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13(th) Street, Room 5101, Boston, MA 02129, USA. Electronic address: rzhang5@partners.org.
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Laurence A
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Turka
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017634:Self Tolerance; D014157:Transcription Factors / Q000378:metabolism*; D000096927:AIRE Protein
D014157:Transcription Factors; D000096927:AIRE Protein