Profound systemic inflammatory response syndrome following non-emergent intestinal surgery in children.
OBJECTIVE
Systemic inflammatory response syndrome (SIRS) is an uncommon but severe complication in surgical patients. While SIRS is well known, it is poorly described in the pediatric population. The goal of this study was to describe the incidence of profound SIRS following non-emergent intestinal surgery in children and to identify potential risk factors.


METHODS
A retrospective review was conducted for patients 0-19 years of age following intestinal surgery and/or lysis of adhesions from 01/01/1999-02/28/2012. Children were excluded for preoperative instability or frank bowel perforation. Patients were then placed in a post-operative SIRS or non-SIRS group as defined by the 2005 International Pediatric Sepsis Consensus Conference Guidelines (6. B. Goldstein, B. Giroir, A. Randolph, and Sepsis International Consensus Conference on Pediatric, 'International Pediatric Sepsis Consensus Conference: Definitions for Sepsis and Organ Dysfunction in Pediatrics', Pediatr Crit Care Med, 6 (2005), 2-8.).


RESULTS
SIRS was identified in 17 of the 381 patients. Logistic regression analysis was performed and showed heart disease, kidney disease, PN dependence, and intestinal obstruction to be predictive of post-operative SIRS.


CONCLUSIONS
This study represents one of the first reports to identify a previously poorly described process of significant SIRS after intestinal surgery in children. Both systemic organ failure and intestinal dysfunction are strong risk factors for post-operative SIRS in children. Potentially, these pre-existing conditions may lead to disruption of normal intestinal flora or barrier function, which in turn may predispose these children to dramatic SIRS episodes after intestinal surgery. Understanding how these factors lead to SIRS will be critical to developing prevention strategies.
Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, MI 48109-0245, USA.
Bhani K
BK
Chawla
Daniel H
DH
Teitelbaum
D000293:Adolescent; D018988:Bacterial Translocation; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D013505:Digestive System Surgical Procedures; D004198:Disease Susceptibility; D017558:Elective Surgical Procedures; D004760:Enterocolitis / Q000453:epidemiology; D006331:Heart Diseases / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007415:Intestinal Obstruction / Q000453:epidemiology; D007422:Intestines / Q000382:microbiology; D007674:Kidney Diseases / Q000453:epidemiology; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000209:etiology; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
Intestinal surgery; Parenteral nutrition; SIRS; Systemic inflammatory response syndrome