Non-immune hydrops fetalis caused by herpes simplex virus type 2 in the setting of recurrent maternal infection.
We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.
Division of Neonatology, Department of Pediatrics, University of Minnesota Amplatz Children's Hospital, Minneapolis, MN, USA.
K M
KM
Pfister
M R
MR
Schleiss
R C
RC
Reed
T N
TN
George
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D005321:Extraembryonic Membranes / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000821:virology; D006558:Herpes Genitalis / Q000150:complications*; D006801:Humans; D015160:Hydrops Fetalis / Q000188:drug therapy / Q000821:virology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000628:therapy / Q000821:virology*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000821:virology*; D012008:Recurrence; D055815:Young Adult
D000998:Antiviral Agents; D000212:Acyclovir