High-sensitivity cardiac troponin T levels in newly diagnosed hypertensive patients with different left ventricle geometry.
BACKGROUND
The high-sensitivity cardiac troponin T (hs-cTnT) assay provides important prognostic information on cardiovascular diseases. Although hs-cTnT is associated with left ventricle (LV) hypertrophy (LVH), it has not been investigated in different LV geometric patterns incorporating normal LV structure and concentric remodeling in addition to LVH.


OBJECTIVE
We aimed to investigate the possible association between hs-cTnT and LV geometric patterns in newly diagnosed hypertensive patients.


METHODS
We studied 306 patients with newly diagnosed hypertension (HT; mean age 51.7 ± 5.6 years) and 44 healthy control subjects (mean age 51.3 ± 4.7 years). Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in hypertensive patients according to LV mass index (LVMI) and relative wall thickness (RWth). hs-cTnT and other biochemical markers were measured in all participants.


RESULTS
The highest hs-cTnT values were observed in the concentric hypertrophy group compared with the control, normal geometry, concentric remodeling and eccentric hypertrophy groups (p < 0.05, for all). Also, hs-cTnT values of the eccentric hypertrophy group were higher than the control, normal geometry and concentric remodeling groups (p < 0.05, for all). Multivariate regression analysis showed that hs-cTnT was independently associated with LV geometry (β = 0.326, p = 0.001) as well as LVMI (β = 0.228, p = 0.010) and creatinine level β = 0.132, p = 0.012).


CONCLUSIONS
hs-cTnT level is related not only to LVH but also to LV geometry in hypertensive patients. hs-cTnT levels may mediate poorer LV geometric patterns in hypertensive patients.
Adana Numune Training and Research Hospital, Department of Cardiology , Adana , Turkey.
Hakan
H
Uçar
Mustafa
M
Gür
Ali
A
Kivrak
Nermin Yildiz
NY
Koyunsever
Taner
T
Seker
Rabia Eker
RE
Akilli
Caner
C
Türkoğlu
Onur
O
Kaypakli
Durmuş Yildiray
DY
Sahin
Zafer
Z
Elbasan
Halil İbrahim
Hİ
Tanboğa
Murat
M
Cayli
D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020107:Troponin T / Q000378:metabolism*
D020107:Troponin T
Geometry; high-sensitivity troponin; hypertension; hypertrophy