Antimicrobial evaluation of new synthesized pyridine nucleosides under solvent-free conditions.
Two series of novel 3-cyano-2-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxo) pyridines and 3-cyano-2-(2,3,5-tri-O-acetyl-β-D-ribofuranosyloxy)-4-trifluromethyl-6-phenyl pyridine were synthesized using efficient microwave methods. The targeted compounds were obtained in high yields by reacting 2-(1H)-pyridone or its salt with activated sugars using SiO₂ under solvent-free conditions. Ammonolysis of the resulted acetylated nucleosides produced 3-cyano-2-(β-D-glucopyranosyloxo)-pyridines and 3-cyano-2-(β-D-ribofuranosyloxy)-4-trifluoromethyl-6-phenyl pyridine. These new products were fully characterized using 1D and 2D NMR. These compounds were screened for their antibacterial activities against G(+) and G(-) bacteria and some found to exhibit better antibacterial activities than the control drug.
a Department of Chemistry, Faculty of Science , Cairo University , Cairo , Egypt.
Nora M
NM
Rateb
Hany A
HA
El-Deab
Ibrahim M
IM
Abdou
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005960:Glucosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012266:Ribose / Q000031:analogs & derivatives* / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
D000890:Anti-Infective Agents; D005960:Glucosides; D009705:Nucleosides; D011725:Pyridines; D012997:Solvents; D012266:Ribose; D012822:Silicon Dioxide; C023666:pyridine