What do we know about resistance to colistin in Enterobacteriaceae in avian and pig production in Europe?
Colistin is a cyclic decapeptide bound to a fatty acid chain. It is active against many Gram-negative bacteria by destabilising the bacterial outer membrane. Bacteria can become resistant to colistin by modification of their lipopolysaccharide, thereby reducing the affinity of polymyxins. Colistin is often administered orally in poultry and pig production to control colibacillosis. Resistant isolates are sometimes recovered from pathological cases, particularly in piglets. However, in Europe the percentage of resistance to colistin in Escherichia coli strains isolated from the digestive tract microbiota of healthy animals remains <1%.
ANSES, Ploufragan-Plouzané Laboratory, BP 53, 22440 Ploufragan, France; Université européenne de Bretagne, Rennes, France. Electronic address: isabelle.kempf@anses.fr.
Isabelle
I
Kempf
Mickaël Alain
MA
Fleury
Djamel
D
Drider
Mireille
M
Bruneau
Pascal
P
Sanders
Claire
C
Chauvin
Jean-Yves
JY
Madec
Eric
E
Jouy
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D005060:Europe; D005516:Food Microbiology; D011200:Poultry; D013552:Swine
D000900:Anti-Bacterial Agents; D003091:Colistin
Colistin; Escherichia coli; Pig; Poultry; Resistance