Effect of dielectric constant on protonation equlibria of L-dopa and 1, 10 -phenanthroline in dioxan-water mixtures.
Solute-solvent interactions of L-dopa and 1, 10-phenanthroline have been studied in 0-60% v/v dioxan-water media using pH-metric method. The protonation constants have been calculated with the computer program MINIQUAD75. Selection of the best fit chemical model of the protonation equilibria is based on standard deviation in protonation constants and residual analysis using crystallographic R-factor and sum of squares of residuals in all mass balance equations. Linear variation of protonation constants with inverse of dielectric constants of the solvent mixture has been attributed to the dominance of the electrostatic forces. Distribution of species, protonation equilibria and effect of influential parameters on the protonation constants have also been presented.
Karri Venkata Santhee
KV
Devi
Bendi Rama
BR
Raju
Gollapalli Nageswara
GN
Rao