Phenotypical analysis, relation to malignancy and prognostic relevance of ICOS+T regulatory and dendritic cells in patients with gliomas.
We determined circulating T helper, T regulatory and ICOS+T regulatory as well as DC cell counts in 29 patients with cerebral gliomas. Samples from patients with gliomas vs. healthy controls and from patients with glioblastomas vs. patients with glioma WHO grades I-III contained significantly (p<0.05) decreased numbers of total as well as mature, i.e. myeloid and plasmacytoid DCs. Patients with glioblastomas demonstrated significantly lower values of CD4+ as well as an increased fraction of ICOS+T regulatory/CD4+ cells. Higher CD4+ cell counts (≥225 cells/μl, median) were associated with improved survival in glioblastomas.
Department of Neurosurgery, University Hospital of Bonn, Sigmund-Freud-Strasse 25, 53105, Germany. Electronic address: kostasgousias@yahoo.com.
Konstantinos
K
Gousias
Alexander
A
von Ruecker
Paraskevi
P
Voulgari
Matthias
M
Simon
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D001932:Brain Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D005910:Glioma / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein / Q000378:metabolism*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016019:Survival Analysis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D055815:Young Adult
D015703:Antigens, CD; C556692:ICOS protein, human; D060889:Inducible T-Cell Co-Stimulator Protein
DC-based immunotherapy; Glioblastomas; ICOS; Mature dendritic cells; T regulatory cells