Serum lipopolysaccharide-binding protein as a marker of atherosclerosis.
BACKGROUND
Recently, serum lipopolysaccharide-binding protein (LBP) has been closely associated with coronary artery disease. Here, we aimed to investigate the possible relationship between serum LBP and markers of atherosclerosis.


METHODS
Serum LBP and carotid intima media thickness (C-IMT) were measured in 332 subjects (101 men and 231 women) who were recruited from an ongoing multicenter project.


RESULTS
Serum LBP was significantly associated with obesity [BMI, fat mass and waist circumference (r > 0.38, p < 0.0001)], HOMA (r = 0.36, p < 0.0001) and high sensitivity CRP (hsCRP) (r = 0.50, p < 0.0001). Circulating LBP was also positively associated with C-IMT (r = 0.27, p < 0.0001). Circulating LBP (β = 0.16; p = 0.001) contributed independently to C-IMT variance, after controlling for the effects of age, gender, BMI and hsCRP. Of note, circulating LBP was found to be increased in the population with carotid plaque (n = 50; 32.7 ± 12.5 vs 28.7 ± 10.7; p = 0.021).


CONCLUSIONS
The consistent association between serum LBP and the carotid intima media thickness, a widely used atherosclerosis marker, reveals serum LBP as a putative factor related to atherosclerosis.
Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
Marta
M
Serrano
José María
JM
Moreno-Navarrete
Josep
J
Puig
María
M
Moreno
Ester
E
Guerra
Francisco
F
Ortega
Gemma
G
Xifra
Wifredo
W
Ricart
José Manuel
JM
Fernández-Real
D000209:Acute-Phase Proteins; D000328:Adult; D000368:Aged; D000886:Anthropometry; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000473:pathology; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D055105:Waist Circumference; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein
Atherosclerosis; High sensitivity CRP; LBP; Obesity