Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity.
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: agbowie@tcd.ie.
Andrew G
AG
Bowie
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D000099197:STING Protein
D004247:DNA; D005090:Exodeoxyribonucleases; D008565:Membrane Proteins; D010750:Phosphoproteins; C530855:Sting1 protein, mouse; D000099197:STING Protein; C429526:three prime repair exonuclease 1