Serum and cerebrospinal fluid levels of visinin-like protein-1 in acute encephalopathy with biphasic seizures and late reduced diffusion.
BACKGROUND
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) has recently been recognized as an encephalopathy subtype. Typical clinical symptoms of AESD are biphasic seizures, and MRI findings show reduced subcortical diffusion during clustering seizures with unconsciousness after the acute phase. Visinin-like protein-1 (VILIP-1) is a recently discovered protein that is abundant in the central nervous system, and some reports have shown that VILIP-1 may be a prognostic biomarker of conditions such as Alzheimer's disease, stroke, and brain injury.


METHODS
However, there have been no reports regarding serum and cerebrospinal fluid (CSF) levels of VILIP-1 in patients with AESD. We measured the serum and CSF levels of VILIP-1 in patients with AESD, and compared the levels to those in patients with prolonged febrile seizures (FS).


RESULTS
Both serum and CSF levels of VILIP-1 were significantly higher in patients with AESD than in patients with prolonged FS. Serum and CSF VILIP-1 levels were normal on day 1 of AESD.


CONCLUSIONS
Our results suggest that both serum and CSF levels of VILIP-1 may be one of predictive markers of AESD.
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan. Electronic address: shunji@yamaguchi-u.ac.jp.
Shunji
S
Hasegawa
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Takeshi
T
Matsushige
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Hirofumi
H
Inoue
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Midori
M
Takahara
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Madoka
M
Kajimoto
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Hiroshi
H
Momonaka
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Momoko
M
Oka
Department of Pediatrics, Tsudumigaura Handicapped Children's Hospital, Japan.
Hiroshi
H
Isumi
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Sakie
S
Emi
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan.
Megumi
M
Hayashi
Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan; Department of Pediatrics, Tsudumigaura Handicapped Children's Hospital, Japan.
Takashi
T
Ichiyama
D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001927:Brain Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D051596:Neurocalcin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012640:Seizures / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D015415:Biomarkers; D051596:Neurocalcin; C496688:VSNL1 protein, human
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD); Febrile seizure; VILIP-1