Lessons from neurolathyrism: a disease of the past & the future of Lathyrus sativus (Khesari dal).
Neurolathyrism is past history in India since Lathyrus sativus (khesari dal) is no longer used as a staple. A consensus has evolved that khesari dal is harmless as part of a normal diet. L-ODAP (β-N-oxalyl-l-α-diamino propionic acid) the neurotoxic amino acid, from this pulse, is detoxified in humans but not in animals but still no laboratory animal is susceptible to it under acceptable feeding regimens. L-ODAP is an activator of protein kinase C and consequential crucial downstream effects such as stabilization of hypoxia inducible factor-1 (HIF-1) could be extremely conducive to humans under a variety of situations. ODAP is gradually finding a place in several patents for this reason. Homoarginine the second amino acid from L. sativus can be a better substrate for endogenous generation of nitric oxide, a crucial signaling molecule associated with the cardiovasculature and control of hypertension. These features could make L. sativus a prized commodity as a functional food for the general cardiovasculature and overcome hypoxic events and is set to change the entire perception of this pulse and neurolathyrism.
Department of Biochemistry, Osmania University, Hyderabad, India.
Surya S
SS
Singh
S L N
SL
Rao
D000599:Amino Acids, Diamino / Q000633:toxicity; D000818:Animals; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007194:India / Q000453:epidemiology; D007842:Lathyrism / Q000453:epidemiology / Q000503:physiopathology*; D027807:Lathyrus / Q000633:toxicity*; D011493:Protein Kinase C / Q000378:metabolism
D000599:Amino Acids, Diamino; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C100126:oxalyldiaminopropionic acid; D011493:Protein Kinase C