Effects of testosterone on visuospatial function and verbal fluency in postmenopausal women: results from a functional magnetic resonance imaging pilot study.
OBJECTIVE
This study aims to investigate the effects of testosterone on cognitive performance during functional magnetic resonance imaging (fMRI) in healthy estrogen-treated postmenopausal women.


METHODS
This was an open-label study in which postmenopausal women on nonoral estrogen therapy were treated with transdermal testosterone for 26 weeks. Women performed tests of verbal fluency (number of words) and mental rotation (reaction time and accuracy) during pretreatment and posttreatment fMRI. Blood oxygen level-dependent (BOLD) signal intensity was measured during fMRI tasks.


RESULTS
Nine women with a mean (SD) age of 55.4 (3.8) years completed the study. Twenty-six weeks of testosterone therapy was associated with significant decreases in BOLD intensity during the mental rotation task in the right superior parietal, left inferior parietal, and left precuneus regions, and during the verbal fluency task in the left inferior frontal gyrus, left lingual gyrus, and medial frontal gyrus (all P < 0.05), with no change in task performance, accuracy, or speed.


CONCLUSIONS
Testosterone therapy is associated with reduced BOLD signal activation in key anatomical areas during fMRI verbal fluency and visuospatial tasks in healthy estrogen-treated postmenopausal women. Our interpretation is that testosterone therapy facilitates preservation of cognitive function with less neuronal recruitment.
From the 1Women's Health Research Program, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; 2Howard Florey Institute and 3Center for Neuroscience, University of Melbourne, Parkville, Victoria, Australia; 4Mental Health Research Institute of Victoria, Parkville, Victoria, Australia; 5Monash-Alfred Psychiatry Research Center, Central Clinical School, Faculty of Medicine, Nursing, and Health Sciences, Alfred Hospital, Prahran, Victoria, Australia; 6Brain and Psychological Sciences Research Center, Swinburne University, Hawthorn, Victoria, Australia; and 7Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia.
Susan R
SR
Davis
Sonia L
SL
Davison
Maria
M
Gavrilescu
Karissa
K
Searle
Andrea
A
Gogos
Susan L
SL
Rossell
Gary F
GF
Egan
Robin J
RJ
Bell
D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000187:drug effects; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009424:Nervous System Physiological Phenomena; D010865:Pilot Projects; D017698:Postmenopause / Q000502:physiology*; D013037:Spatial Behavior; D013060:Speech / Q000502:physiology; D013739:Testosterone / Q000627:therapeutic use*; D014796:Visual Perception
D013739:Testosterone