O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation.
Post-translational modifications play important roles in transcriptional regulation. Among the less understood PTMs is O-GlcNAcylation. Nevertheless, O-GlcNAcylation in the nucleus is found on hundreds of transcription factors and coactivators and is often found in a mutually exclusive ying-yang relationship with phosphorylation. O-GlcNAcylation also links cellular metabolism directly to the proteome, serving as a conduit of metabolic information to the nucleus. This review serves as a brief introduction to O-GlcNAcylation, emphasizing its important thematic roles in transcriptional regulation, and highlights several recent and important additions to the literature that illustrate the connections between O-GlcNAc and transcription.
Metabolism Branch, CCR/NCI/NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: lewisbri@mail.nih.gov.
Brian A
BA
Lewis
D000117:Acetylglucosamine / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D014158:Transcription, Genetic
D012319:RNA Polymerase II; D000117:Acetylglucosamine
Nutrient sensor; O-GlcNAc; RNA polymerase II; Transcription