Risk factors for comorbidities in Czech psoriatic patients: results of a hospital-based case-control study.
BACKGROUND
Psoriasis is now known to be associated with multiple other diseases/comorbidities - including the metabolic syndrome, atherosclerosis and gastrointestinal diseases which are all significantly higher in psoriasis patients. Research results however are highly variable and the conclusions are ambiguous. As no similar study has been performed to date in Czech psoriatic patients, this study aimed at identifying risk factors and early stages of selected diseases/comorbidities in the patients.


RESULTS
The study was designed as a hospital-based case-control study. 131 patients with chronic plaque psoriasis formed the cases and 267 patients with other skin disorders formed the controls. A comparison was made of basic demographic and anthropometric indicators, metabolic parameters, the presence of specific antibodies (ASCA, AEP, p-ANCA, AGC, EMA, ARA, t-TG, AGA) and non-specific signs of gastrointestinal diseases. The chi squared, MWU tests and binary logistical model were used to evaluate the data. The results showed significant differences (P<0.05) for the following parameters: blood pressure, waist circumference, weight, BMI values, leucocytes values, HDL cholesterol level, glycemia and gliadine antibody IgA level. All differences were to the detriment of psoriasis patients. In the binary logistical model the following parameters were associated with psoriasis: diastolic blood pressure, leucocyte value and glycemia. For all variables included in the logistical model P≤0.001.


CONCLUSIONS
The results were coherent and consistent with existing data. They indicate that psoriasis is interconnected with hypertension, higher BMI and a decreased level of HDL cholesterol. These parameters have been clearly demonstrated as risk factors for the development of cardiovascular diseases. Higher levels of gliadine IgA antibodies are one of the diagnostic markers of celiac disease. Higher values of leukocytes may be interpreted as a nonspecific indicator of gastrointestinal inflammatory diseases. The associations between psoriasis and diastolic blood pressure, BMI value and glycemia are statistically significant in the binary logistic regression model. Care for psoriatic patients should focus especially on secondary prevention of predisposing diseases.
Department of Dermatovenereology, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Jana
J
Votrubova
Katerina
K
Juzlova
Zdenek
Z
Smerhovsky
Jorga
J
Fialova
Dana
D
Gopfertova
Nadezda
N
Vojackova
Jana
J
Hercogova
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood; D015897:Comorbidity; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology*; D005903:Gliadin / Q000276:immunology; D006761:Hospitals; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D011565:Psoriasis / Q000453:epidemiology*; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
D001323:Autoantibodies; D001786:Blood Glucose; D008076:Cholesterol, HDL; D005903:Gliadin