Posttraumatic elbow joint contractures: defining pathologic capsular mechanisms and potential future treatment paradigms.
The Andrew J. Weiland Medal is presented by the American Society for Surgery of the Hand to a midcareer researcher who is dedicated to advancing patient care in the field of hand surgery. This essay, awarded the Weiland Medal in 2012, focuses on posttraumatic elbow joint contractures. Joint contractures are well known to hand surgeons because they limit function of our patients. There is a thorough understanding of the pathoanatomy underlying joint contractures. However, the mechanisms leading to the pathoanatomy are either unknown or partially understood, depending on the etiology of the particular clinical condition. This review describes our research over the past 14 years on posttraumatic elbow joint contractures. It defines pathologic cellular, matrix, and growth factor changes in the joint capsule, elaborates on the development of an animal model of posttraumatic joint contractures, presents an evaluation of a potential prevention strategy based on our research, and outlines future plans to bring this work to the clinical realm for the benefit of patients.
Department of Surgery, University of Calgary and Alberta Health Services-Calgary Zone, Calgary, Alberta, Canada.. Electronic address: hildebrk@ucalgary.ca.
Kevin A
KA
Hildebrand
D000818:Animals; D003286:Contracture / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004551:Elbow Joint / Q000473:pathology; D006801:Humans; D017746:Joint Capsule / Q000473:pathology / Q000503:physiopathology*; D007665:Ketotifen / Q000627:therapeutic use; D058628:Myofibroblasts; D000092464:Elbow Injuries
D007665:Ketotifen
elbow; joint capsule; joint contractures; mast cells; myofibroblasts