[Association between SNP rs12740374 and acute ischemic stroke in Chinese Han population].
OBJECTIVE
To investigate the association between single nucleotide polymorphism (SNP) rs12740374 and acute ischemic stroke in Chinese Han population.


METHODS
All subjects (778 ischemic stroke patients and 602 controls) were genotyped using ligation detection reaction (LDR). We analyzed the differences among all genotypes in two groups, as well as the association between rs12740374 and low-density lipoprotein cholesterol (LDL-C).


RESULTS
All three genotypes (GG, GT, TT) of rs12740374 were found in both stroke and control group. After adjusting for risk factors, although there was a trend that participants with a minor allele T of rs12740374 (GT/TT) had lower LDL-C concentration, no significant association was found between rs12740374 and ischemic stroke, and also no significant association between different genotypes and LDL-C was found.


CONCLUSIONS
SNPs of rs12740374 was not significantly associated with ischemic stroke in the Chinese Han population.
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Jing-Jing
JJ
Zhang
Li-Hua
LH
Yu
Yan-Ying
YY
Yin
Qian
Q
Lu
Lei
L
Lei
Jing
J
Xiao
Jian
J
Guo
Jing-Jing
JJ
Zhao
Ya-Nan
YN
Wang
Guo-Qian
GQ
He
Yan-Ming
YM
Xu
Li
L
He
D000368:Aged; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics*
D008078:Cholesterol, LDL