Iron-catalyzed decarboxylative alkenylation of cycloalkanes with arylvinyl carboxylic acids via a radical process.
A Fe(acac)3-catalyzed decarboxylative coupling of 2-(aryl)vinyl carboxylic acids with cycloalkanes was developed by using DTBP as an oxidant through a radical process. This reaction tolerates a wide range of substrates, and products are obtained in good to excellent yields (71-95%). The reaction also shows excellent stereoselectivity, and only trans-isomers are obtained.
School of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
Jiancan
J
Zhao
Hong
H
Fang
Jianlin
J
Han
Yi
Y
Pan
Fe(acac)3; alkenylation; cycloalkanes; decarboxylative; free radical; sp3 C–H bonds