Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer.
In this issue of Cell Reports, Li et al. show that the analysis of genetic changes in patient-derived xenografts can reveal crucial details of tumor evolution, such as the emergence of functional estrogen receptor mutations in endocrine-resistant breast cancer.
Women's Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, Magee-Womens Hospital and Magee-Womens Research Institute, Departments of Pharmacology and Chemical Biology and Medicine, University of Pittsburgh, Pittsburgh 15213, USA. Electronic address: oesterreichs@upmc.edu.
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D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans
C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha