Phase quantification of antihypertensive drugs - Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide - by the Rietveld method.
The identification and quantification of crystalline phases of antihypertensive drugs - Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P21/c. After one year storage, the orthorhombic one was also observed in this sample.
Departamento de Química - ICE, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, Minas Gerais, Brazil.
Weberton
W
Reis do Carmo
Fabio Furlan
FF
Ferreira
Renata
R
Diniz
D047228:Angiotensin II Type 1 Receptor Blockers / Q000032:analysis; D000959:Antihypertensive Agents / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D002752:Chlorthalidone / Q000032:analysis*; D003460:Crystallization; D004232:Diuretics / Q000737:chemistry; D004355:Drug Stability; D006852:Hydrochlorothiazide / Q000032:analysis*; D019808:Losartan / Q000032:analysis*; D011208:Powders; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D004232:Diuretics; D011208:Powders; D006852:Hydrochlorothiazide; D019808:Losartan; D002752:Chlorthalidone
A graphical user interface for GSAS; AT1; Bck; CTD; Chlorthalidone; EXPGUI; GSAS; HCTZ; HIV; Hydrochlorothiazide; Hydrochlorothiazide and Rietveld method; LOS-K; Losartan potassium; Polymorphism; SHO; Thompson-Cox-Hastings pseudo-Voigt; U(iso); X-ray diffraction; X-ray diffractometry; XRD; angiotensin II receptor type 1; background; general structure analysis system; human immunodeficiency virus; isotropic atomic displacements; pV-TCHZ; spherical harmonic order