[Expression of pin1 in endometrial carcinoma and its relation with PR].
OBJECTIVE
To investigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma.


METHODS
The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens.


RESULTS
Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression.


CONCLUSIONS
Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.
Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha Hunan, 410078, China.E-mail: lilithtian@163.com.
Yan
Y
Tian
Yi
Y
Zhang
Jingjing
J
Yu
Yu
Y
Zhang
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D011980:Receptors, Progesterone; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase