[Exploring the association rules of clinical application of shenmai injection through text mining].
OBJECTIVE
To explore the rules of clinical application of Shenmai Injection (SI).


METHODS
The data sets of SI were downloaded from CBM database by the method of literature retrieved from Jan. 1980 to May 2012. Rules of Chinese medical patterns, diseases, symptoms, Chinese patent medicines (CPM), and Western medicine (WM) were mined out by data slicing algorithm, and they were demonstrated in frequency tables and two-dimension based network.


RESULTS
Totally 3 159 literature were recruited. Results showed that SI was most frequently correlated with stasis syndrome and deficiency syndrome. Heart failure, arrhythmia, myocarditis, myocardial infarction, and shock were core diseases treated by SI. Symptoms such as angina pectoris, fatigue, chest tightness/pain were mainly relieved by SI. For CPM, SI was most commonly used with Compound Danshen Injection, Astragalus Injection, and so on. As for WM, SI was most commonly used with nitroglycerin, fructose, captopril, and so on.


CONCLUSIONS
The syndrome types and mining results of SI were the same with its instructions. Stasis syndrome was the potential Chinese medical pattern of SI. Heart failure, arrhythmia, and myocardial infarction were potential diseases treated by SI. For CPM, SI was most commonly used with Danshen Injection, Compound Danshen Injection, and so on. And for WM, SI was most commonly used with nitroglycerin, fructose, captopril, and so on.
Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Lin-Lin
LL
Zhang
Hong-Tao
HT
Guo
Guang
G
Zheng
Li-Mei
LM
Liu
Zhi-Qian
ZQ
Song
Ai-Ping
AP
Lu
Zhen-Li
ZL
Liu
D057225:Data Mining; D016208:Databases, Factual; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D027561:Salvia miltiorrhiza
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; C028972:dan-shen root extract