E2F1: a potential therapeutic target for systematic lupus erythematosus.
E2F1 is a transcriptional activator, which binds to DNA, and regulates the expression of genes involved in the cell cycle progression. Many elegant studies have revealed that E2F1 plays a crucial role in regulating the apoptosis process of DC and T cells. In addition, the pathogenesis of SLE involves marked immune dysfunction, and in particular, the function of immunosuppressive elements of the immune system is impaired, including regulatory T cell function and DC. Thus, therapeutic agents targeting E2F1 might result in important innovative therapies for SLE.
Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, 230032, People's Republic of China.
Xin-Yu
XY
Fang
Dong-Qing
DQ
Ye
D050687:E2F1 Transcription Factor / Q000235:genetics*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D012333:RNA, Messenger / Q000097:blood*
D050687:E2F1 Transcription Factor; D035683:MicroRNAs; D012333:RNA, Messenger