Bioactive flavone-C-glycosides of the African medicinal plant Biophytum umbraculum.
Three flavone-C-glycosides-cassiaoccidentalin A (1), isovitexin (2) and isoorientin (3)-were isolated from the ethyl acetate (EtOAc) soluble fraction of the methanol crude extract of the African medicinal plant Biophytum umbraculum, This is the first report of these compounds in this plant. All compounds were identified by spectroscopic analysis and comparison with published data. Isoorientin (3) and the EtOAc extract showed the greatest antioxidant activity in the DPPH assay as well as the strongest inhibition of xanthine oxidase (XO) and 15-lipoxygenase (15-LO). From these results, the extract of B. umbraculum might be a valuable source of flavone C-glycosides.
Section of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway. a.t.pham@farmasi.uio.no.
Anh Thu
AT
Pham
Celine
C
Nguyen
Karl Egil
KE
Malterud
Drissa
D
Diallo
Helle
H
Wangensteen
D047310:Apigenin / Q000737:chemistry* / Q000302:isolation & purification; D001093:Arachidonate 15-Lipoxygenase / Q000737:chemistry; D047309:Flavones / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D047311:Luteolin / Q000737:chemistry* / Q000302:isolation & purification; D019684:Magnoliopsida / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000737:chemistry
D047309:Flavones; D016166:Free Radical Scavengers; D006027:Glycosides; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; C000592379:cassiaoccidentalin A; D047310:Apigenin; C057912:homoorientin; D001093:Arachidonate 15-Lipoxygenase; D014969:Xanthine Oxidase; C049772:isovitexin; D047311:Luteolin