VEGF +936C/T and +460C/T gene polymorphisms and oral cancer risk: a meta-analysis.
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, we performed a meta-analysis. The PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were searched for case-control studies that were published up to January 2013. Data were extracted and pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated. Ultimately, six studies were included, comprising 1006 oral cancer cases and 1016 controls. Overall, the pooled OR for VEGF +936 T allele carriers (TC + TT) versus the wild-type homozygotes (CC) was 1.28 (95 % CI 1.04-1.58; P = 0.228 for heterogeneity), the pooled OR for TT versus CC was 1.64 (95 % CI 1.34-1.98; P = 0.315 for heterogeneity), and the pooled OR for the T allele versus the C allele was 1.42 (95 % CI 1.22-1.76; P = 0.286 for heterogeneity). In the stratified analysis by ethnicity, significant risks were found among Caucasians but not Asians. However, there were no associations between VEGF +460C/T and oral cancer risk in only two of the included studies. In conclusion, this meta-analysis demonstrates that the VEGF +936 T allele may be associated with an increased risk of oral cancer, especially among Caucasian populations.
Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Medical School, Nanjing University, 30 Zhong Yang Road, Nanjing, 210008, People's Republic of China.
Su-Feng
SF
Zhao
Ping
P
Zhan
Xu-Dong
XD
Yang
Ming-Xing
MX
Lu
Guo-Wen
GW
Sun
Yu-Xin
YX
Wang
Yin-Kai
YK
Zhang
Yu-Mei
YM
Pu
En-Yi
EY
Tang
D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D009062:Mouth Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A