Coupling reaction of thioamides with sulfonyl azides: an efficient catalyst-free click-type ligation under mild conditions.
We report a coupling reaction of thioamides and sulfonyl azides to generate sulfonyl amidines in the absence of any activation additives. The reaction progresses in various solvents under mild conditions. Water exhibits the highest performance with respect to efficiency.
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. chiba@pha.u-toyama.ac.jp yasu@pha.u-toyama.ac.jp.
Muhammad
M
Aswad
Junya
J
Chiba
Takenori
T
Tomohiro
Yasumaru
Y
Hatanaka
D000578:Amidines / Q000138:chemical synthesis / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*; D013854:Thioamides / Q000737:chemistry*
D000578:Amidines; D001386:Azides; D013450:Sulfones; D013854:Thioamides