Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH-MYCNmice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the innate immune system as well as immunosuppressive mediators such as transforming growth factor β (TGFβ) and thromboxane A2. These findings pave novel avenues for the clinical management of neuroblastoma.
Childhood Cancer Research Unit; Department of Women's and Children's Health; Karolinska Institutet; Stockholm, Sweden.
Lena-Maria
LM
Carlson
Per
P
Kogner
MYCN; aspirin; cyclooxygenase 1; dendritic cell; myeloid-derived suppressor cell; neuroblastoma; prostaglandin D2; thromboxane A2; tumor-associated macrophage