Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes.
Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.
From the *Department of Pediatrics, L. Sacco Hospital, University of Milan; †Unit of Clinical Pharmacology, L. Sacco University Hospital, Università degli Studi di Milano; ‡Consiglio Nazionale delle Ricerche Institute of Neuroscience, Milan, Italy; and §Eugenio Medea Scientific Institute, Bosisio Parini (LC), Italy.
Vania
V
Giacomet
Dario
D
Cattaneo
Alessandra
A
Viganò
Pilar
P
Nannini
Valeria
V
Manfredini
Giulia
G
Ramponi
Emilio
E
Clementi
Gian Vincenzo
GV
Zuccotti
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics* / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000235:genetics* / Q000652:urine / Q000821:virology; D007684:Kidney Tubules / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D020641:Polymorphism, Single Nucleotide; D000068698:Tenofovir; D055815:Young Adult
D000225:Adenine; D019380:Anti-HIV Agents; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D063065:Organophosphonates; D000068698:Tenofovir; C000715087:ABCC2 protein, human