Complications of endoscopic ultrasound fine needle aspiration on pancreatic cystic lesions: final results from a large prospective multicenter study.
BACKGROUND
Endoscopic ultrasound-guided fine needle aspiration of pancreatic cystic lesions has been reported to have a higher complication rate than that of solid lesions, but the real complication rate is unknown. Aim of the study was to identify the complication rate of endoscopic ultrasound-guided fine needle aspiration and related risk factors.


METHODS
Prospective multicenter study at four referral centres. Data were collected from January 2010 to July 2012, searching for all adverse events related to guided fine needle aspiration. All complications occurring up to day 90 were recorded.


RESULTS
298 patients (43.9% male, mean age 63.2 ± 15.4 years) underwent endoscopic ultrasound-guided needle aspiration of pancreatic cystic lesions. Mean size was 34.1 ± 9 mm. Adverse events occurred in 18 patients (6%): mild complications in 12/18 (66.6%), and moderate complications in 6/18 (33.3%). Seven were immediate, 6 early, and 5 late. All resolved with medical therapy.


CONCLUSIONS
Endoscopic ultrasound-guided fine needle aspiration of pancreatic cystic lesions has been found to be associated with a higher complication rate than for solid lesions; however, the risk rate is acceptable considering the complication grade and the important diagnostic role of the technique in the management of pancreatic cystic lesions.
Gastroenterology Department, ISMETT/UPMC (Mediterranean Institute for Transplantation and Advanced Specialized Therapies/University of Pittsburgh Medical Center in Italy), Palermo, Italy. Electronic address: itarantino@ismett.edu.
Ilaria
I
Tarantino
Gastroenterology Department, AUSL Bologna, Bellaria-Maggiore Hospital, Bologna, Italy.
Carlo
C
Fabbri
Gastroenterology Department, Civico-A.R.N.A.S. Hospital, Palermo, Italy.
Roberto
R
Di Mitri
Gastroenterology Department, Humanitas Irccs, Rozzano, Milan, Italy.
Nico
N
Pagano
Gastroenterology Department, ISMETT/UPMC (Mediterranean Institute for Transplantation and Advanced Specialized Therapies/University of Pittsburgh Medical Center in Italy), Palermo, Italy.
Luca
L
Barresi
Gastroenterology Department, Civico-A.R.N.A.S. Hospital, Palermo, Italy.
Filippo
F
Mocciaro
Gastroenterology Department Ferrara University, Ferrara, Italy.
Antonella
A
Maimone
Gastroenterology Department, ISMETT/UPMC (Mediterranean Institute for Transplantation and Advanced Specialized Therapies/University of Pittsburgh Medical Center in Italy), Palermo, Italy.
Gabriele
G
Curcio
Gastroenterology Department, Humanitas Irccs, Rozzano, Milan, Italy.
Alessandro
A
Repici
Gastroenterology Department, ISMETT/UPMC (Mediterranean Institute for Transplantation and Advanced Specialized Therapies/University of Pittsburgh Medical Center in Italy), Palermo, Italy.
Mario
M
Traina
D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D015331:Cohort Studies; D003537:Cystadenoma / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000473:pathology; D018293:Cystadenoma, Serous / Q000473:pathology; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000473:pathology*; D010181:Pancreatic Cyst / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011183:Postoperative Complications; D011446:Prospective Studies
Cyst of the pancres; EUS-FNA; Pancreatic cystic lesions