The treatment of acute myocardial infarction: the Past, the Present, and the Future.
Since Herrick's description of the clinical picture of acute myocardial infarction exactly one century ago (1912), there have been three phases of therapy: Phase 1 (1912-1961, bed rest and 'expectant' treatment); Phase 2 (1961-1974, the coronary care unit); and Phase 3 (1975-present, myocardial reperfusion). We are now on the cusp of Phase 4, which comprises efforts to reduce myocardial perfusion injury as well as regenerative medicine.
The TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.
Eugene
E
Braunwald
Myocardial infarction; coronary care unit; myocardial reperfusion; reperfusion injury