Fabrication of core-shell nanoparticles via controlled aggregation of semi-flexible conjugated polymer and hyaluronic acid.
Core-shell conjugated polymer nanoparticles (CPNs) were fabricated by complexing a semi-flexible, primary amine-containing conjugated polymer (CP) with hyaluronic acid (HA). Flexibility introduced in the rigid rod conjugated backbone allows backbone reorganization to increase π-π interaction under ionic complexation, resulting in core-shell nanoparticles with a hydrophobic CP core wrapped with a HA shell. The core-shell nanoparticles exhibited no cellular toxicity and high cancer cell specificity with minimal binding to normal cells.
Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8 St., Miami, FL 33199, USA.
Megan
M
Twomey
Yoonmi
Y
Na
Zahilyn
Z
Roche
Eladio
E
Mendez
Namuna
N
Panday
Jin
J
He
Joong Ho
JH
Moon