S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate.
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 °C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.
School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.
Vaibhav P
VP
Mehta
Michael F
MF
Greaney