IFITMs restrict the replication of multiple pathogenic viruses.
The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.
Microbiology and Physiological Systems (MaPS) Department, University of Massachusetts Medical School, Albert Sherman Center 8 1001, 368 Plantation Street, Worcester, MA 01655, USA.
Jill M
JM
Perreira
Christopher R
CR
Chin
Eric M
EM
Feeley
Abraham L
AL
Brass
D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D003716:Dengue Virus / Q000276:immunology* / Q000502:physiology; D029043:Ebolavirus / Q000276:immunology* / Q000502:physiology; D016174:Hepacivirus / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology; D007372:Interferons / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018448:Models, Immunological; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D053586:Virus Internalization; D014779:Virus Replication / Q000276:immunology*
D000943:Antigens, Differentiation; D008565:Membrane Proteins; C062010:leu-13 antigen; D007372:Interferons
AS; CCHFV; CD225 family; CIL; CMEM; Crimean Congo hemorrhagic fever virus; DENV; EBOV; Ebola virus; GP; HCV; HIV-1; IAV; IFITM; IFN; JSRV; Jaagsiekte sheep retrovirus; MARV; MLV; MS; Marburg virus; Moloney leukemia virus; N-terminal domain; NTD; OSBP; RVFV; Rift Valley fever virus; SARS CoV; SeV; Sendai virus; VAPA; alanine scanning; clathrin-mediated endocytosis motif; conserved intracellular loop; dengue virus; glycoprotein; hepatitis C virus; host virus interactions; human immunodeficiency virus type 1; influenza A virus; interferon; interferon effector genes; interferon-inducible transmembrane protein; mass spectrometry; oxysterol binding protein; restriction factor; severe acute respiratory syndrome coronavirus; vesicle-associated membrane protein-A