Effect of acetohydroxamic acid on prevention of canine struvite uroliths.
Long-term administration of acetohydroxamic acid (AHA) to dogs with experimentally induced urease-positive staphylococcal urinary tract infections, and bladder zinc disk foreign bodies inhibited urolith growth in 2 dogs and prevented urolith growth in 4 dogs. Inhibition and prevention of urolith growth were associated with reduction in urine urease activity, crystalluria, pyuria, hematuria, and proteinuria. Lesions in the urinary tract of AHA-treated dogs were less severe than those of infected control dogs. Administration of AHA for 6 months induced mild morphologic abnormalities in RBC, but did not cause hemolytic anemia.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA.
D R
DR
Krawiec
C A
CA
Osborne
J R
JR
Leininger
D P
DP
Griffith
D000818:Animals; D001437:Bacteriuria / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006863:Hydrogen-Ion Concentration; D006877:Hydroxamic Acids / Q000009:adverse effects / Q000494:pharmacology*; D011776:Pyuria / Q000139:chemically induced / Q000662:veterinary; D001744:Urinary Bladder Calculi / Q000517:prevention & control / Q000662:veterinary*; D014556:Urine / Q000737:chemistry
D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; C006358:acetohydroxamic acid