Cobalt-catalyzed hydrofluorination of unactivated olefins: a radical approach of fluorine transfer.
Catalytic hydrofluorination of olefins using a cobalt catalyst was developed. The exclusive Markovnikov selectivity, functional group tolerance, and scalability of this reaction make it an attractive protocol for the hydrofluorination of olefins. A preliminary mechanistic experiment showed the involvement of a radical intermediate.
Faculty of Pharmacy, Musashino University , 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo, 202-8585, Japan.
Hiroki
H
Shigehisa
Eriko
E
Nishi
Mayu
M
Fujisawa
Kou
K
Hiroya
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
D000475:Alkenes; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D005461:Fluorine; D003035:Cobalt