Cannabinoid receptor 2 activation: a means to prevent monocyte-endothelium engagement.
This Commentary highlights the article by Rom et al which shows that selective cannabinoid receptor 2 activation in leukocytes decreases key steps in monocyte-blood brain barrier engagement suppressing inflammatory leukocyte responses and preventing neuroinflammation.
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: sbuch@unmc.edu.
Shilpa J
SJ
Buch
D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism* / Q000473:pathology*; D004727:Endothelium / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism*
D043885:Receptor, Cannabinoid, CB2