Cytokine signaling in the differentiation of innate effector cells.
Innate effector cells, including innate effector cells of myeloid and lymphoid lineages, are crucial components of various types of immune responses. Bone marrow progenitors differentiate into many subsets of innate effector cells after receiving instructional signals often provided by cytokines. Signal transducer and activator of transcription (STATs) have been shown to be essential in the differentiation of various types of innate effector cells. In this review, we focus specifically on the differentiation of innate effector cells, particularly the role of cytokine signaling in the differentiation of innate effector cells.
Division of Allergy and Immunology; Department of Medicine; National Jewish Health; Denver, CO USA ; Integrated Department of Immunology; University of Colorado School of Medicine; Denver, CO USA.
Hua
H
Huang
Yapeng
Y
Li
Xiaopeng
X
Qi
STATs; cytokine; differentiation; innate effector cells; transcription factor