Genomic linkage between Alzheimer's disease and type 2 diabetes.
Alzheimer's disease (AD) is a major health concern that affects nearly every society worldwide. The disease is an irreversible, progressive and age-related neurodegenerative disorder. It is characterized by impaired cognitive function and the diffuse deposition of amyloid plaques and neurofibrillary tangles. The causes of AD and the underlying mechanisms that trigger the onset of the disease are still a matter of debate. Several epidemiological studies have shown that the development of AD is associated with type 2 diabetes mellitus (T2D). In this review, we provide evidence for the link between T2D and AD, highlighting the critical role of insulin in the pathogenesis of these diseases, and we provide information on the genes that might be involved in the interplay between these two disorders. New insight into the complex biology of AD is necessary for the early diagnosis of the disease, the development of novel drug therapies and the prevention of these health issues.
Taoufik
T
Nedjadi
Absarul
A
Haque
Qamre
Q
Alam
Siew H
SH
Gan
Adeel G
AG
Chaudhary
Adel M
AM
Abuzenadah
Ghazi A
GA
Damanhouri
Fundamental and Applied Biology Group, King Fahd Medical Research Centre, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia. absar99@gmail.com.
Mohammad A
MA
Kamal
D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D023281:Genomics; D006801:Humans; D007328:Insulin / Q000378:metabolism
D007328:Insulin