Controlled block copolymer micelle formation for encapsulation of hydrophobic ingredients.
We report on the formation of polymeric micelles in water using triblock copolymers with a polyethylene glycol middle block and various hydrophobic outer blocks prepared with the precipitation method. We form micelles in a reproducible manner with a narrow size distribution. This suggests that during the formation of the micelles the system had time to form micelles under close-to-thermodynamic control. This may explain why it is possible to use an equilibrium self-consistent field theory to predict the hydrodynamic size and the loading capacity of the micelles in accordance with experimental finding. Yet, the micelles are structurally quenched as concluded from the observation of size stability in time. We demonstrate that our approach enables to prepare rather hydrophobic block copolymer micelles with tunable size and loading.
DSM Biomedical, P.O. Box 18, 6160 MD, Geleen, The Netherlands.
Jérôme G J L
JG
Lebouille
Leo F W
LF
Vleugels
Aylvin A
AA
Dias
Frans A M
FA
Leermakers
Martien A
MA
Cohen Stuart
Remco
R
Tuinier
D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*; D013816:Thermodynamics
D008823:Micelles; D011092:Polyethylene Glycols