Palladium-catalyzed C-2 selective arylation of quinolines.
An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province , Lanzhou 730000, P. R. China.
Xiaoyu
X
Ren
Ping
P
Wen
Xiaokang
X
Shi
Yuling
Y
Wang
Jian
J
Li
Sizhuo
S
Yang
Hao
H
Yan
Guosheng
G
Huang
D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; D011804:Quinolines; D010165:Palladium