Synthesis, spectroscopic characterisation, DNA cleavage, superoxidase dismutase activity and antibacterial properties of some transition metal complexes of a novel bidentate Schiff base derived from isatin and 2-aminopyrimidine.
Complexes of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) with a Schiff base, formed by the condensation of isatin with 2-aminopyrimidine have been synthesised and characterised through elemental analysis, molar conductance measurements, magnetic susceptibility, IR, UV-Vis, (1)HNMR, FAB mass and EPR spectral studies. The spectral data revealed that the ligand acts as neutral bidentate, coordinating to the metal ion through the carbonyl oxygen and azomethine nitrogen. Molar conductance values adequately support the electrolytic nature of the complexes. On the basis of the above observations the complexes have been formulated as [M(ISAP)2]X2, where M=Mn(II), Co(II), Ni(II), Cu(II) and Zn(II); X=Cl, OAc; ISAP=2-[N-indole-2-one]aminopyrimidine. The ligand and copper(II) complex were subjected to X-ray diffraction studies. The DNA cleavage study was monitored by gel electrophoresis method. The superoxide dismutase (SOD) mimetic activities of the ligand and the metal complexes were checked using NBT assay. The in vitro antibacterial activity of the synthesized compounds has been tested against gram negative and gram positive bacteria.
Department of Chemistry, University of Kerala, Trivandrum, 695581 Kerala, India.
L P
LP
Nitha
R
R
Aswathy
Niecy Elsa
NE
Mathews
B Sindhu
BS
Kumari
K
K
Mohanan
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053837:DNA Cleavage / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D007510:Isatin / Q000737:chemistry*; D008024:Ligands; D060328:Magnetic Phenomena; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013482:Superoxide Dismutase / Q000378:metabolism*; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D008024:Ligands; D011743:Pyrimidines; D012545:Schiff Bases; C012180:2-aminopyrimidine; D007510:Isatin; D013482:Superoxide Dismutase
Antibacterial activity; DNA cleavage; EPR spectrum; Schiff base; Superoxide dismutase; XRD