Propofol and fentanyl take longer for induction of anesthesia in aortic regurgitation: a case-controlled prospective study.
OBJECTIVE
This study was conducted to determine if induction time of anesthesia in patients with aortic regurgitation (AR) is different from patients with a normal aortic valve (AV).


METHODS
A prospective, case-control study.


METHODS
A single institutional study conducted in a tertiary care teaching hospital.


METHODS
Twenty-four male patients scheduled for cardiac surgery, group I (n = 12) patients with competent AV and group 2 (n = 12) with severe AR.


METHODS
General anesthesia was induced by intravenous infusion of propofol and fentanyl.


RESULTS
Continuous measurements of heart rate, intra-arterial blood pressure, and bispectral index were recorded. Induction doses of propofol and fentanyl were analyzed and compared. There was significant difference between the 2 groups in terms of induction time of anesthesia (mean ± SD 308 ± 68.2 seconds in group 1 v 445 ± 97.9 seconds in group 2). The patients in group 2 (AR) required significantly larger doses of propofol (0.91 ± 0.40 mg/kg) than the patients in group 1 (0.49 ± 0.17 mg/kg). Similarly, fentanyl dose was increased in the group 2 patients (20.8 ± 15.9 µg/kg) compared with the group 1 patients (9.2 ± 2.9 µg/kg).


CONCLUSIONS
The authors concluded that there was a significant prolongation of the induction time of anesthesia and the need of larger doses of propofol and fentanyl by slow intravenous infusion regimen in patients with AR compared with patients with a competent aortic valve.
Department of Anesthesiology, Sahara Hospital, Lucknow, India.
Soumya S
SS
Nath
Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. Electronic address: mukesh_tripathi@yahoo.com.
Mukesh
M
Tripathi
Department of Anaesthesiology, Medanta Medicity, Gurgaon, India.
Sudipto
S
Banerjee
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous / Q000009:adverse effects / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001835:Body Weight / Q000502:physiology; D016022:Case-Control Studies; D056805:Consciousness Monitors; D001026:Coronary Artery Bypass; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies
D018686:Anesthetics, Intravenous; D005283:Fentanyl; D015742:Propofol
aortic regurgitation; bispectral index; fentanyl; induction time; propofol