Biointegration of the osteo-odonto lamina in the modified osteo-odonto keratoprosthesis: engineering of tissue to restore lost vision.
The modified osteo-odonto keratoprosthesis (MOOKP) is a biologic keratoprosthesis that is used to treat a severely scarred cornea. The procedure involves multiple stages, including the transplantation of buccal mucosa to the damaged ocular surface and the implantation of an osteo-odonto lamina with a mounted polymethylmethacrylate lens. Among the keratoprostheses currently available, the MOOKP has proven to be the most effective based on the number of patients who have undergone the procedure and the duration of documented follow-up. Upon successful biointegration of the osteo-odonto lamina, the keratoprosthesis is able to resist resorption, provide stability, and prevent bacterial invasion and epithelial ingrowth. The effectiveness of the MOOKP is dependent on the anatomic and physiologic characteristics of the dental tissues and periodontal ligament.
Yoh
Y
Sawatari
Robert E
RE
Marx
Victor L
VL
Perez
Jean-Marie
JM
Parel
D000328:Adult; D001705:Bioprosthesis; D016025:Bone Transplantation / Q000379:methods*; D002921:Cicatrix / Q000209:etiology / Q000601:surgery*; D003315:Cornea / Q000601:surgery; D003316:Corneal Diseases / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D019919:Prosthesis Implantation / Q000379:methods*; D013262:Stevens-Johnson Syndrome / Q000150:complications; D023822:Tissue Engineering / Q000379:methods*; D014070:Tooth / Q000637:transplantation*; D014786:Vision Disorders / Q000601:surgery; D014785:Vision, Ocular
D019904:Polymethyl Methacrylate