Psychiatric comorbidities in allodynic migraineurs.
OBJECTIVE
To evaluate the prevalence and the association of psychological disturbance in migraine patients with allodynia.


METHODS
We recruited 434 migraine patients from an outpatient clinic. The participants completed three self-administered questionnaires, including a headache questionnaire, an allodynia symptoms checklist, and the Hospital Anxiety and Depression Scale (HADS).


RESULTS
Among the migraineurs, 48.4% participants reported allodynia. The HADS total score (15.5 ± 7.8 vs. 13.7 ± 8.5, P  = 0.022) and anxiety subscore (9.1 ± 4.5 vs. 7.6 ± 4.7, P  = 0.001) were higher in migraineurs with allodynia than in those without allodynia. The anxiety subscore in patients with moderate to severe allodynia, mild allodynia, and no allodynia were 10.0 ± 4.5, 8.4 ± 4.3, and 7.6 ± 4.7 ( P  < 0.001, by one-way analysis of variance). Among patients with moderate to severe allodynia, there was a trend of higher depression subscore (7.1 ± 4.0, P  = 0.059) than those with no (6.1 ± 4.4) or mild allodynia (5.8 ± 4.0). In a regression model, the presence of allodynia is an independent risk factor for clinically significant anxiety. Moderate to severe allodynia is an independent risk factor for clinically significant depression.


CONCLUSIONS
In migraineurs, the severity of cutaneous allodynia was associated with their mood status, especially anxiety.
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan.
Chi-Han
CH
Kao
Shuu-Jiun
SJ
Wang
Chia-Fen
CF
Tsai
Shih-Pin
SP
Chen
Yen-Feng
YF
Wang
Jong-Ling
JL
Fuh
D000328:Adult; D017677:Age Distribution; D001008:Anxiety Disorders / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology; D008881:Migraine Disorders / Q000453:epidemiology* / Q000523:psychology; D010147:Pain Measurement / Q000706:statistics & numerical data; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology
Depression; allodynia; anxiety; migraine