Regioselective Heck reaction of aliphatic olefins and aryl halides.
A regioselective Heck reaction of aliphatic olefins and aryl bromides is realized at internal carbons of olefins. Methanol solvent promoted halide ionization from neutral arylpalladium halide complexes via hydrogen bonding, so as to create cationic aryl-Pd species for regioselective olefin insertion.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371. jrzhou@ntu.edu.sg.
Liena
L
Qin
Hajime
H
Hirao
Jianrong Steve
JS
Zhou