Synthesis, spectral characterization and catalytic activity of Co(II) complexes of drugs: crystal structure of Co(II)-trimethoprim complex.
New Co(II) complexes with drugs such as trimethoprim (TMP), cimetidine (CTD), niacinamide (NAM) and ofloxacin (OFL) as ligands were synthesized. The complexes were characterized by analytical analysis, various spectral techniques such as FT-IR, UV-Vis, magnetic measurements and molar conductivity. The magnetic susceptibility results coupled with the electronic spectra suggested a tetrahedral geometry for the complexes. The coordination mode of trimethoprim ligand and geometry of the complex were confirmed by single crystal X-ray studies. In this complex the metal ion possesses a tetrahedral geometry with two nitrogen atom from two TMP ligands and two chloride ions coordinated to it. The catalytic activity of the complexes in aryl-aryl coupling reaction was screened and the results indicated that among the four complexes [Co(OFL)Cl(H2O)] exhibited excellent catalytic activity.
Department of Chemistry, Gandhigram Rural Institute, Deemed University, Gandhigram 624 302, India.
Selvaraj
S
Madhupriya
Kuppanagounder P
KP
Elango
D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D004583:Electrons; D008024:Ligands; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014295:Trimethoprim / Q000138:chemical synthesis* / Q000737:chemistry*
D056831:Coordination Complexes; D008024:Ligands; D004364:Pharmaceutical Preparations; D003035:Cobalt; D014295:Trimethoprim
Catalytic activity; Co(II) complex; Drugs