Molecular characterization of Staphylococcus aureus and influenza virus coinfections in patients with fatal Pneumonia.
Molecular techniques were used to characterize genetic features of Staphylococcus aureus in 66 fatal cases of pneumonia caused by S. aureus and influenza A or B viruses. Nucleic acids were extracted from formalin-fixed, paraffin-embedded tissues. The majority of cases revealed genetic markers for Panton-Valentine leukocidin, mecA, and spa type t008.
Division of High-Consequence Pathogens and Pathology.
Amy M
AM
Denison
Marlene
M
Deleon-Carnes
Dianna M
DM
Blau
Eric C
EC
Shattuck
Linda K
LK
McDougal
James K
JK
Rasheed
Brandi M
BM
Limbago
Sherif R
SR
Zaki
Christopher D
CD
Paddock
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000382:microbiology* / Q000821:virology*; D005098:Exotoxins / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications* / Q000821:virology; D007956:Leukocidins / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000235:genetics / Q000302:isolation & purification*; D046915:Penicillin-Binding Proteins; D011023:Pneumonia, Staphylococcal / Q000150:complications* / Q000382:microbiology; D013205:Staphylococcal Protein A / Q000235:genetics; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification*; D055815:Young Adult
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D046915:Penicillin-Binding Proteins; D013205:Staphylococcal Protein A; C487789:mecA protein, Staphylococcus aureus