Profiling of hla-B alleles for association studies with ankylosing spondylitis in the chinese population.
Human leucocyte antigen (HLA) B*27 is a susceptibility allele to ankylosing spondylitis (AS). However, major AS-associated subtypes of HLA-B*27 and other HLA-B alleles vary in different ethnic populations. Herein, we examined HLA-B alleles in a total of 360 AS patients and 350 controls of Chinese Han ancestry. The HLA-B genotyping was performed with sequence-based typing (SBT) method. Six HLA-B*27 subtypes B*27:04, B*27:05, B*27:07, B*27:08, B*27:10 and B*27:15 were observed in the cohorts. HLA-B*27:04:01 and -B*27:05:02 appeared significantly increased in AS patients, which indicated as two major susceptibility alleles to AS. Homozygous B*27 was observed only in AS patients. There are 30 HLA-B alleles identified in the studies. HLA-B*15, especially B*15:01:01:01, appeared as the major allele type in the Chinese controls. Some common HLA-B alleles such as HLA-B*15, B*13, B*46 and B*51 were significantly reduced in Chinese AS patients. In conclusion, the studies profiled the HLA-B alleles, and identified major susceptibility subtypes of B27 to AS in Han Chinese population.
Division of Rheumatology and Clinical Immunogenetics, University of Texas Medical School at Houston, USA ; Gansu College of Traditional Chinese Medicine, Lanzhou, Gansu, China.
Lin
L
Yi
Jiucun
J
Wang
Xinjian
X
Guo
Maribel G
MG
Espitia
Enuo
E
Chen
Shervin
S
Assassi
Li
L
Jin
Hejian
H
Zou
John D
JD
Reveille
Xiaodong
X
Zhou
Ankylosing spondylitis (AS); Chinese Han.; HLA-B27