Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole.
Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed.
Departamento de Física, Universidade Federal do Ceará, CP 6030, Fortaleza, Ceará 60455-760, Brazil.
Sara Braga
SB
Honorato
Jorge Souza
JS
Mendonça
Nubia
N
Boechat
Alcemira Conceição
AC
Oliveira
Josué
J
Mendes Filho
Javier
J
Ellena
Alejandro Pedro
AP
Ayala
D014355:Chagas Disease / Q000188:drug therapy; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D009593:Nitroimidazoles / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole
Benznidazole; Hot stage microscopy; Infrared spectroscopy; Polymorphism; Thermal analysis; X-ray powder diffraction