Acute olanzapine overdose in a toddler: a case report.
We describe a 17-month-old female presented with an acute overdose of olanzapine, an atypical antipsychotic. She displayed prolonged extrapyramidal symptoms as compared with that in previous reports and prolactin levels above the upper limits of normal ranges. This is the first report to measure serum prolactin levels in an olanzapine-overdosed toddler and the second to calculate olanzapine's elimination half-life.
*Division of Clinical Pharmacology and Toxicology; †Division of Clinical Biochemistry, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, The University of Toronto; and ‡Clinical Laboratory and Diagnostic Services, Centre for Addiction and Mental Health, Toronto, Canada.
Reo
R
Tanoshima
Weerawadee
W
Chandranipapongse
David
D
Colantonio
Cristiana
C
Stefan
Irena
I
Nulman
D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000506:poisoning*; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood* / Q000150:complications*; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D000077152:Olanzapine; D011388:Prolactin / Q000097:blood
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D011388:Prolactin; D000077152:Olanzapine