Diterpenoids and sesquiterpenoids from the roots of Illicium majus.
Five new diterpenoids (1-5), five new sesquiterpenoids (6-10), and three known compounds (11-13) were isolated from the roots of Illicium majus. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was assigned by X-ray crystallography, whereas those of the 1,2-diol moieties in 3 and 4 were determined using Snatzke's method. The abietane acids 1, 2, 11, 12, and 13 displayed antiviral activity against the Coxsackie B3 virus, with IC50 values of 3.3-51.7 μM/mL.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
Ya-Dan
YD
Wang
Gui-Jie
GJ
Zhang
Jing
J
Qu
Yu-Huan
YH
Li
Jian-Dong
JD
Jiang
Yun-Bao
YB
Liu
Shuang-Gang
SG
Ma
Yong
Y
Li
Hai-Ning
HN
Lv
Shi-Shan
SS
Yu
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029822:Enterovirus B, Human / Q000187:drug effects; D029523:Illicium / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C585300:(15S)-16-hydroxyabieta-8,11,13-trien-19-oic acid; D045784:Abietanes; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes