A new macrolide from a marine-derived fungus Aspergillus sp.
A new 16-membered macrolide named aspergillide D (1), along with six known compounds, including two polyketones (2-3) and four alkaloids (4-7), were isolated from the culture broth of a marine-derived fungus Aspergillus sp. SCSGAF 0076. The structure of 1 was elucidated on the basis of NMR and mass spectra. Compound 5 showed an obvious inhibitory effect on influenza virus strains H1N1 and H3N2.
Key Laboratory of Marine Bio-resources Sustainable Utilization/RNAM Center for Marine Microbiology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
Jie
J
Bao
Xin-Ya
XY
Xu
Xiao-Yong
XY
Zhang
Shu-Hua
SH
Qi
D000470:Alkaloids / Q000302:isolation & purification; D059001:Aquatic Organisms / Q000737:chemistry; D001230:Aspergillus / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests
D000470:Alkaloids; D018942:Macrolides; C584639:aspergillide D