Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus.
Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.
Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany.
Nadine
N
Krüger
Markus
M
Hoffmann
Michael
M
Weis
Jan Felix
JF
Drexler
Marcel Alexander
MA
Müller
Christine
C
Winter
Victor Max
VM
Corman
Tim
T
Gützkow
Christian
C
Drosten
Andrea
A
Maisner
Georg
G
Herrler
D000349:Africa; D000818:Animals; D001210:Asia, Southeastern; D002460:Cell Line; D002685:Chiroptera / Q000821:virology*; D015726:Giant Cells / Q000821:virology*; D045403:Henipavirus / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D045464:Henipavirus Infections / Q000662:veterinary* / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*
D014759:Viral Envelope Proteins