The genetics of juvenile idiopathic arthritis: current understanding and future prospects.
Understanding the genetic risk of JIA, a relatively rare chronic disease, is a challenging task, but recent research in this field has shown great advances. This review summarizes the current understanding of the genetic architecture of JIA susceptibility and proposes where this work is heading in the coming years. Insights into how we might progress this relatively understudied field will be provided, highlighting how the field will move towards the ultimate goals of predicting long-term disease outcomes at onset, predicting drug response, and move towards more targeted treatment options for children with JIA.
Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Institute of Inflammation and Repair, University of Manchester, Oxford Road, Manchester M13 9PT, UK. joanna.cobb@manchester.ac.uk.
Joanna E
JE
Cobb
Anne
A
Hinks
Wendy
W
Thomson
D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000235:genetics*; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D011379:Prognosis
D018501:Antirheumatic Agents
autoimmune disease; genetics; juvenile idiopathic arthritis; predicting drug response