The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications.
Recent publications have shown that the combination of α-calcium sulfate hemihydrate, the densest form of hydrates and hydroxyapatite (HA) particles gives good clinical outcome in various applications. It has large potential as bone substitute since the material transforms to bone throughout the entire volume and not only by creeping substitution, from the surface toward the inside. Release of important proteins for osteogenesis has been observed around implanted material and is speculated to be due to fast dissolution of the calcium sulfate phase in combination with the osteoconductive and bioactive nature of HA. In diabetic foot infection, the osteoconductive HA/calcium sulfate material has been successfully used loaded with antibiotics and since it is injectable, the application is minimally invasive, easy and precise. It is a bone substitute for the future.
Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Malin
M
Nilsson
Ming H
MH
Zheng
Magnus
M
Tägil
D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry* / Q000627:therapeutic use*; D002133:Calcium Sulfate / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D017886:Durapatite / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D016062:Porosity
D018786:Bone Substitutes; D017886:Durapatite; D002133:Calcium Sulfate