[Investigation on equilibrium solubility and apparent oil/water partition coefficient of diterpenoid tanshinone component by similarity analysis methods].
OBJECTIVE
To study the equilibrium solubility and apparent oil/water partition coefficient of diterpenoid tanshinone component by similarity analysis methods, so as to lay the foundation for Salvia diterpenoid quinone component of the overall solubility characterization.


METHODS
Taking Salvia diterpenoid quinone component as model drug, determined the equilibrium solubility and partition coefficients of the components in different buffer, evaluated the degree of similarity of each component based on the cosine and Grubbs.


RESULTS
The representative composition of Salvia diterpenoid quinone component, namely dihydrotanshinone I, tanshinone I, cryptotanshinone and tanshinone II(A) had similar properties of equilibrium solubility and partition coefficients in different pH buffer. This similarity was not only manifested in the trends, but also reflected the value.


CONCLUSIONS
This similarity assessment reflected the degree of deviation and dispersion of components, which was applicable to the study of the components; the similarity assessment could increase the science and rationality of component evaluation, and at the same time could optimize the structure of the component.
Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. xiaoyu9456@sina.com
Dan-Hong
DH
Yu
Xiao-Bin
XB
Jia
D045784:Abietanes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009821:Oils / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
D045784:Abietanes; D009821:Oils; C021751:tanshinone; D014867:Water