Dual modality endomicroscope with optical zoom capability.
We present a miniature endomicroscope that combines large field-of-view (FOV) (1.15 mm) reflectance imaging with high-resolution (~0.5 μm) multiphoton intrinsic fluorescence imaging. We acquired in vivo and ex vivo images of unstained normal and tumor-laden tissues by using the large-FOV mode to navigate to the site of interest and then switching to the high-resolution modality to resolve cellular details.
Schol of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853, USA.
Dimitre G
DG
Ouzounov
David R
DR
Rivera
Wendy O
WO
Williams
John A
JA
Stupinski
Teresa L
TL
Southard
Kelly H
KH
Hume
Julie
J
Bentley
Robert S
RS
Weiss
Watt W
WW
Webb
Chris
C
Xu
(110.2350) Fiber optics imaging; (170.2150) Endoscopic imaging; (180.4315) Nonlinear microscopy