Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms.
OBJECTIVE
Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.


METHODS
We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile.


RESULTS
The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels.


CONCLUSIONS
These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Eun Ran
ER
Kim
Mun Hee
MH
Yang
Yeun Jung
YJ
Lim
Jin Hee
JH
Lee
Dong Kyung
DK
Chang
Young-Ho
YH
Kim
Hee Jung
HJ
Son
Jae J
JJ
Kim
Jong Chul
JC
Rhee
Jin Yong
JY
Kim
Colorectal neoplasms; Plasminogen activator inhibitor 1