NIAID meeting report: improving malaria vaccine strategies through the application of immunological principles.
A highly efficacious vaccine to prevent malaria infection or clinical disease is still far from reality despite several decades of intensive effort and a growing global commitment in malaria vaccine development. Further understanding of the mechanisms required for induction of effective host immune responses and maintenance of long-term protective immunity is needed to facilitate rational approaches for vaccine design and evaluation. The National Institute of Allergy and Infectious Diseases (NIAID) conducted a workshop on June 18-19, 2012 with experts in the fields of malaria vaccine development, malaria immunology, and basic immunology to address issues associated with improving our current understanding of malaria vaccine immunity. This report summarizes the discussion and major recommendations generated by the workshop participants regarding the application of recent advances in basic immunology and state-of-the-art immunological tools to improve progress and help address current challenges and knowledge gaps in malaria vaccine development.
National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health, Department of Health and Human Service, Bethesda, MD 20892, USA.
Annie X Y
AX
Mo
National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Health, Department of Health and Human Service, Bethesda, MD 20892, USA. Electronic address: Augustine@niaid.nih.gov.
Alison Deckhut
AD
Augustine
D000818:Animals; D035843:Biomedical Research; D003226:Congresses as Topic; D009033:Culicidae / Q000469:parasitology; D006801:Humans; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission; D017780:Malaria Vaccines / Q000276:immunology*; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D014481:United States
D017780:Malaria Vaccines
Adaptive immunity; Conference report; Innate immunity; Malaria vaccine