Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy.
OBJECTIVE
To evaluate the effects of perioperative oral administration of carprofen and meloxicam on concentrations of 3 acute-phase proteins in dogs undergoing elective ovariohysterectomy (OVH).


METHODS
18 healthy adult anestrous female dogs undergoing elective OVH.


METHODS
Dogs were allocated to 3 groups (6 dogs/group). A placebo treatment, carprofen (2.0 mg/kg), or meloxicam (0.2 mg/kg) was orally administered to the dogs of the respective groups. The initial doses were administered 30 minutes before premedication prior to OVH; additional doses were administered once daily for 4 days after surgery. Blood samples were collected 45 minutes before premedication and 4, 8, 12, 24, 36, 48, 72, 96, and 120 hours after the end of OVH; samples were used for measurement of total WBC and neutrophil counts and concentrations of C-reactive protein (CRP), ceruloplasmin, and fibrinogen.


RESULTS
Values did not differ significantly among groups for WBC and neutrophil counts, serum concentrations of CRP and ceruloplasmin, and plasma concentrations of fibrinogen. Concentrations of all inflammatory markers, except serum ceruloplasmin, increased significantly following OVH, but in a similar manner for each group. No significant changes were detected in serum ceruloplasmin concentrations over time.


CONCLUSIONS
Perioperative administration of both carprofen and meloxicam did not significantly affect the concentrations of CRP, ceruloplasmin, and fibrinogen in dogs undergoing OVH. Thus, use of carprofen or meloxicam should not affect clinical interpretation of results for these 3 acute-phase proteins.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Adnan Menderes, PK: 17, 09016, Isikli, Aydin, Turkey.
Cavit
C
Kum
Huseyin
H
Voyvoda
Selim
S
Sekkin
Umit
U
Karademir
Tugrul
T
Tarimcilar
D000284:Administration, Oral; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis*; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D002570:Ceruloplasmin / Q000032:analysis*; D004285:Dogs; D004338:Drug Combinations; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D007044:Hysterectomy / Q000662:veterinary*; D007958:Leukocyte Count / Q000662:veterinary; D000077239:Meloxicam; D009504:Neutrophils / Q000187:drug effects; D010052:Ovariectomy / Q000662:veterinary*; D019990:Perioperative Care / Q000662:veterinary; D018709:Statistics, Nonparametric; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D002227:Carbazoles; D004338:Drug Combinations; D013843:Thiazines; D013844:Thiazoles; D005340:Fibrinogen; D002097:C-Reactive Protein; D002570:Ceruloplasmin; C007005:carprofen; D000077239:Meloxicam