Giant invasive sacral schwannoma showing chromosomal numerical aberrations [-14,+18,+22].
Here, we report on a rare case of a giant invasive sacral schwannoma. The patient was a 58-year-old woman who had a 6-year history of non-specific buttock pain. Histological investigation confirmed the diagnosis of cellular schwannoma. The following numerical aberration was detected using the GTG-banding method for karyotypes: 47,XX,-14,+18,+22. Cytogenetic studies of schwannomas have indicated a complete or partial loss of chromosome 22 as the most common abnormality, but this case is cytogenetically rare because of the recurrence of trisomy 22.
Department of Human Science, University of Toyama, Toyama, Japan. ; Department of Orthopaedics, University of Toyama, Toyama, Japan.
Masahiko
M
Kanamori
Taketoshi
T
Yasuda
Takeshi
T
Hori
Kayo
K
Suzuki
Cytogenetics; Neurilemmoma; Sacrum