[Vitamin D and neurology].
Vitamin D deficiency is associated with a higher risk of multiple sclerosis and also with a higher relapse rate as well as a higher number of MRI lesions. Elders with vitamin D deficiency have worse cognitive performance. Vitamin D deficiency is a risk factor for developing Alzheimer's disease. Ischemic stroke are more frequent and more severe in patients with low vitamin D levels. Carotid atherosclerosis is more frequent and more severe in patients with vitamin D deficiency. Vitamin D deficiency is associated with a higher risk and worse prognosis of Parkinson's disease. In the different neurological disorders discussed herein, gene polymorphisms that could alter vitamin D metabolism are also associated with a higher incidence or a worse disease prognosis. Despite the links between vitamin D deficiency and the risks of developing neurological disorders, there is, to date, no proof that supplementation could alter the course of these diseases.
Hôpital Carémeau, service de neurologie, place du Pr-Debré, 30029 Nîmes cedex 9, France.
Éric
É
Thouvenot
William
W
Camu
D000544:Alzheimer Disease / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology; D003072:Cognition Disorders / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology; D019587:Dietary Supplements; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology; D009422:Nervous System Diseases / Q000175:diagnosis / Q000178:diet therapy / Q000453:epidemiology*; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D014807:Vitamin D / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*
D014807:Vitamin D