[Treatment of patients with severe glucocorticoid-refractory ulcerative colitis: cyclosporine or infliximab?].
Cyclosporine and infliximab are so-called 'rescue-therapies' as last resort for the treatment of patients with severe glucocorticoid-refractory ulcerative colitis. A recent study found that cyclosporine and infliximab are similar in terms of efficacy in the treatment of patients with severe ulcerative colitis. Cyclosporine may be prescribed as a bridge to treatment with thiopurines; infliximab may be prescribed when a patient is intolerant or refractory to thiopurines. Preoperative treatment with cyclosporine or infliximab does not affect the number of postoperative complications.
Academisch Medisch Centrum, afd. Maag-Darm-Leverziekten, Amsterdam.
Mark
M
Löwenberg
Nanne K H
NK
de Boer
Pieter
P
Dewint
Frank
F
Hoentjen
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000601:surgery; D016572:Cyclosporine / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D016572:Cyclosporine; D000069285:Infliximab