A comparison of two alcohol biomarkers in clinical practice: ethyl glucuronide versus ethyl sulfate.
This study compared the characteristics of two direct alcohol biomarkers, ethyl glucuronide and ethyl sulfate. Both biomarkers were analyzed from urine specimens submitted by 58 active duty service members at Walter Reed National Military Medical Center's Addiction Treatment Service. These 58 individuals, as a result of serial testing, submitted a total of 374 urine specimens for laboratory analysis. Of 374 specimens, the paired tests were most often negative (n = 295, 78.9%).The paired tests were both positive less frequently (n = 38, 10.2%). In an interesting development ethyl sulfate produced more positive results than ethyl glucuronide (n = 32, 8.6%).
a Walter Reed National Military Medical Center , Bethesda , Maryland , USA.
R Gregory
RG
Lande
Barbara
B
Marin
D000328:Adult; D000428:Alcohol Drinking / Q000652:urine*; D000437:Alcoholism / Q000534:rehabilitation* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D000431:Ethanol / Q000378:metabolism*; D005189:False Positive Reactions; D005260:Female; D005965:Glucuronates / Q000652:urine; D006801:Humans; D008297:Male; D008889:Military Personnel; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015813:Substance Abuse Detection / Q000379:methods*; D013463:Sulfuric Acid Esters / Q000652:urine; D055815:Young Adult
D015415:Biomarkers; D005965:Glucuronates; D013463:Sulfuric Acid Esters; C093924:ethyl glucuronide; D000431:Ethanol; C011612:diethyl sulfate