Egr2 and Egr3 are the unique regulators for systemic autoimmunity.
Systemic autoimmunity is characterized by widespread inflammation, autoantibody production and immune complex deposition. The regulatory mechanisms for the systemic autoimmunity are not fully understood. A paper by Li et al. revealed that Egr2 and Egr3, transcription factors required for T-cell anergy, are the regulators for systemic autoimmune disease. They showed evidence that Egr2 and Egr3 control cytokine productions and cell proliferation via SOCS and Batf regulation.
Department of Allergy and Rheumatology; Graduate School of Medicine; The University of Tokyo; Tokyo, Japan.
Shuji
S
Sumitomo
Keishi
K
Fujio
Tomohisa
T
Okamura
Kazuhiko
K
Yamamoto
Batf; Egr2; Egr3; SOCS1; SOCS3; Th17; autoimmunity