Understanding human NK cell differentiation: clues for improving the haploidentical hematopoietic stem cell transplantation.
The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
Department of Experimental Medicine, University of Genova, Genova, Italy.
Elisa
E
Montaldo
Paola
P
Vacca
Lorenzo
L
Moretta
Maria Cristina
MC
Mingari
D000818:Animals; D002454:Cell Differentiation; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000637:transplantation; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D054503:Lymphoid Progenitor Cells / Q000276:immunology*; D058996:Quality Improvement
Allogeneic HSC transplantation; NK cell differentiation; NK cells; NK receptors