Mechanisms of NOD-like receptor-associated inflammasome activation.
A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Haitao
H
Wen
Edward A
EA
Miao
Jenny P-Y
JP
Ting
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000276:immunology / Q000378:metabolism*; D053468:CARD Signaling Adaptor Proteins / Q000276:immunology / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D020170:Caspase 1 / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000276:immunology / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000276:immunology; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D058847:Inflammasomes; C496800:NAIP protein, human; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; C435692:NLRC4 protein, human; C427903:NLRP1 protein, human; C453881:NLRP3 protein, human; D051616:Neuronal Apoptosis-Inhibitory Protein; D018160:Receptors, Cytoplasmic and Nuclear; D020170:Caspase 1