JAK-STAT signaling in stem cells and their niches in Drosophila.
JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules.
MRC Centre for Development and Biomedical Genetics and The Department of Biomedical Science; The University of Sheffield; Sheffield, UK.
Nina
N
Bausek
JAK-STAT; intestinal stem cells; midgut; ovary; stem cell niche; stem cells; testis