Tandem Michael addition/isocyanide insertion into the C-C bond: a novel access to 2-acylpyrroles and medium-ring fused pyrroles.
A new reaction model, tandem Michael addition/formal isocyanide insertion into the acyl C-C bond, has been developed. Thus, a series of 2-acylpyrroles and seven-/eight-membered ring fused pyrroles were synthesized from the reaction of methyl isocyanides with enones in a single operation.
Department of Chemistry, Northeast Normal University, Changchun 130024, China. xuxx677@nenu.edu.cn liuqun@nenu.edu.cn.
Lingjuan
L
Zhang
Xianxiu
X
Xu
Qiu-rong
QR
Shao
Ling
L
Pan
Qun
Q
Liu