In vitro bactericidal effects of near-ultraviolet light from light-emitting diodes on Helicobacter pylori.
We investigated whether near-ultraviolet light emitted from light-emitting diodes (LEDs) effects Helicobacter pylori viability and whether this new method can potentially apply to eradication therapy. Three H. pylori strains were used for near-ultraviolet (UV) LED irradiation experiments. Viability of isolates exposed to near-UV light was compared with controls by counting colony forming units. A time-dependent bactericidal effect of near-UV light was definitely observed. LED irradiation with near-UV light showed effective bactericidal activity against H. pylori strains. Eradication therapy with LED might provide a new avenue of treatment in patients refractory to eradication due to antibiotic resistance and/or adverse effects of antibiotics.
Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine , Yamaguchi , Japan.
Takeshi
T
Okamoto
Jun
J
Nishikawa
Hideo
H
Yanai
Hiroki
H
Nakamura
Hiroaki
H
Takeuchi
Satoshi
S
Kurai
Junko K
JK
Akada
Isao
I
Sakaida
D015169:Colony Count, Microbial; D016480:Helicobacter pylori / Q000254:growth & development / Q000528:radiation effects*; D050296:Microbial Viability / Q000528:radiation effects*; D014466:Ultraviolet Rays