Reduced susceptibility of Candida albicans clinical isolates to azoles and detection of mutations in the ERG11 gene.
We investigated the susceptibility of Candida albicans isolated from clinic specimens to azole antifungal agents and estimated the association of the ERG11 mutations with azole resistance during recent 5years in China. In this study, novel mutations G346A, A434V, and L480F in ERG11 may be related to azole resistance in C. albicans.
Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Lei
L
Zhang
Hai-Fei
HF
Yang
Yan-Yan
YY
Liu
Xi-Hai
XH
Xu
Ying
Y
Ye
Jia-Bin
JB
Li
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D016133:Polymerase Chain Reaction
D000935:Antifungal Agents; D001393:Azoles; D005656:Fungal Proteins
Azoles; Candidiasis; Drug resistance; MICs