The effect of the polymorphisms of 5-HTTLPR on new onset of depression in patients who underwent pacemaker implantation.
OBJECTIVE
To study the role of serotonin transporter gene (5-HTTLPR) polymorphisms in the incidence of depression in a Chinese cohort who underwent pacemaker (PM) implantation.


METHODS
A total of 294 patients treated with PMs were enrolled. The 5-HTTLPR gene polymorphism was determined.


RESULTS
We found that the 5-HTTLPR SS genotype was significantly associated with the risk of depression after PM implantation (odds ratio=3.916, compared with LL carriers, P<0.001), especially in female patients and patients who are smokers. Female SS genotype carries 9.75 times higher risk for depression, and smokers with the SS genotype had 9.45 times higher risk for new onset of depression after the procedure. Pace mode had no influence on the onset of depression.


CONCLUSIONS
This study suggests a significant association between the 5-HTTLPR gene polymorphism and the new onset of depression after PM implantation, especially in women or those who were smokers.
aDepartment of Cardiology, Hangzhou First Municipal Hospital and Hangzhou Hospital, Nanjing Medical University, Hangzhou bDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Jiangsu cDepartment of Pediatrics, Yanzhou General Hospital, Shandong dDepartment of Biostatistics, College of Public Health, Harbin Medical University, Heilongjiang, China.
Haiying
H
Xu
Qing
Q
Zhang
Xuwei
X
Hou
Qingmei
Q
Wang
Yizhou
Y
Xu
Lulu
L
Li
Ningfu
N
Wang
D003863:Depression / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial / Q000523:psychology*; D011110:Polymorphism, Genetic; D019919:Prosthesis Implantation / Q000523:psychology*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins