Localized Intrasplenic Mesothelioma: A Case Report.
Malignant mesothelioma is a primary neoplasm of the serosal membranes that usually presents with a diffuse pattern of growth. However, cases of localized mesotheliomas have been described. The predominant localization is the pleura; peritoneum and pericardium being rarer localizations. Only few cases of true intraparenchymal mesothelioma arising in organs such as liver, gonads, lung, and pancreas have been described. We report a case of an otherwise healthy 48-year-old man without asbestos exposure with a nodule of 3 cm in diameter, localized in the spleen, discovered incidentally at the ultrasonographic examination, for which histopathological and immunohistochemical findings were consistent with epithelioid mesothelioma: large round cells with eosinophil dense cytoplasm and macronucleoli and with immunohistochemical positivity for pancytokeratins, calretinin, Wilms tumor-1, and others markers of mesothelial differentiation. The diagnosis of localized intrasplenic epithelioid malignant mesothelioma was carried out. To the best of our knowledge, this is the first case of a localized intrasplenic mesothelioma published in the indexed literature.
Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy.
Michele
M
Giansanti
Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy guidobellezza@virgilio.it.
Guido
G
Bellezza
Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy.
Angela
A
Guerriero
Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy.
Anjuta
A
Pireddu
Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy.
Angelo
A
Sidoni
D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014463:Ultrasonography
D014408:Biomarkers, Tumor
immunohistochemistry; intraparenchymal; localized; mesothelioma; spleen