Pregnancy offers new insights into mechanisms of breast cancer risk and resistance.
Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest new biomarkers that may improve risk prediction and provide endpoints for assessment of clinical responses to prophylactic therapies.
D Joseph
DJ
Jerry
Grace
G
Makari-Judson
Giovanna M
GM
Crisi
Karen A
KA
Dunphy
D001943:Breast Neoplasms / Q000209:etiology*; D019070:Cell Lineage; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology*; D010298:Parity / Q000235:genetics*; D011247:Pregnancy; D013234:Stem Cells / Q000166:cytology*
D050760:Cyclin-Dependent Kinase Inhibitor p27