In vitro treatments of Echinococcus granulosus with fungal chitosan, as a novel biomolecule.
OBJECTIVE
To determined the antiparasitic activity of the isolated chitosan from Penicillium viridicatum, Penicillium aurantiogriseum and commercial chitosan against protoscolicidal of hydatid cysts were determined.


METHODS
After isolating chitosan from fungal cell walls, four concentrations (50, 100, 200, 400 μg/mL) of each type of prepared chitosan and commercial chitosan were used for 10, 30, 60, and 180 min, respectively.


RESULTS
Among different type of chitosan, commercial chitosan with the highest degree of deacetylation showed high scolicidal activity in vitro. Fungal chitosan could be recommended, as good as commercial chitosan, for hydatic cysts control.


CONCLUSIONS
It seems to be a good alternative to synthetic and chemical scolicidal.
Department of Parasitology, School of Public health, Tehran University of Medical Sciences, Iran.
Bahman
B
Rahimi-Esboei
Mahdi
M
Fakhar
Aroona
A
Chabra
Mahboobeh
M
Hosseini
D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004443:Echinococcosis / Q000662:veterinary; D048209:Echinococcus granulosus / Q000166:cytology / Q000187:drug effects* / Q000302:isolation & purification; D005658:Fungi / Q000737:chemistry*; D012756:Sheep / Q000469:parasitology; D012757:Sheep Diseases
D000871:Anthelmintics; D048271:Chitosan
Chitosan; Echinococcus granulosus; Penicillium; Protoccoleces