Single-stage preputial skin flap urethroplasty for long-segment urethral strictures: evaluation and determinants of success.
OBJECTIVE
To determine the overall efficacy and predictors of success of the penile preputial flap in the management of complex urethral strictures >2.5 cm in length.


METHODS
We performed a retrospective and prospective study of 58 patients undergoing single-stage penile preputial flap urethroplasty for complex long-segment urethral strictures, without lichen sclerosus, repaired between May 2005 and April 2012 at our institution. For obvious reasons circumcised patients were excluded from the study. Results were assessed by univariate analysis of various patient characteristics, preoperative and postoperative patient satisfaction (based on symptoms), and urethral ultrasonography, retrograde urethrography and uroflowmetry.


RESULTS
The median (range) follow-up was 42 (6-90) months, the median (range) intra-operative stricture length was 48.5 (26-85) mm and the median (range) operating time was 90 (85-125) min. A total of 87.93% of patients had a satisfactory outcome, with an overall success rate of 81.03%. Diabetes mellitus (relative risk [RR] 5.21, confidence interval [CI] 2.31-64.68, P = 0.003) and smoking (RR 4.19, CI 1.54- 45.0, P = 0.01) were predictors of failure, while postinfective aetiology (RR 2.19), panurethral stricture (RR 2.73), stricture length >70 mm (RR 3.25), previous urethroplasty (RR 2.4) and severe peri-urethral fibrosis (RR 2.37) were also associated with a higher risk of failure.


CONCLUSIONS
A urologist should try to gain experience of all the methods of urethroplasty as the techniques may vary according to the circumstances. Single-stage preputial skin flap urethroplasty, in experienced and expert hands, has results equivalent to all other methods of urethroplasty in complex urethral strictures. We prefer this technique in this part of the world where buccal mucosa cannot be used because of dyskeratotic changes as a result of consumption of gutkha, tobacco, pan masala, betel nut.
Department of Surgery, Mahatma Gandhi Memorial Medical College and Maharaja Yashwant Rao Hospital, Indore, India.
Raj Kumar
RK
Mathur
Milesh
M
Nagar
Rahul
R
Mathur
Fareed
F
Khan
Chaitanya
C
Deshmukh
Nilesh
N
Guru
D000293:Adolescent; D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D052816:Foreskin / Q000098:blood supply / Q000601:surgery*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011183:Postoperative Complications / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000098:blood supply; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics
complex urethral stricture; determinants of success; preputial skin flap; urethroplasty