Acid-catalyzed reactions of 3-hydroxy-2-oxindoles with electron-rich substrates: synthesis of 2-oxindoles with all-carbon quaternary center.
A Lewis acid catalyzed reaction of in situ generated 2H-indol-2-one () with various 2π and other electron-rich substrates has been developed. A variety of electron-rich substrates such as allyl/methallyltrimethylsilane, phenylacetylene, styrenes, acetophenone, and indoles have been used. The methodology provides a straightforward approach for the synthesis of 2-oxindoles with an all-carbon quaternary center at the pseudobenzylic position.
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, M.P. 460 023, India. alakesh@iiserb.ac.in.
Lakshmana K
LK
Kinthada
Santanu
S
Ghosh
Subhadip
S
De
Subhajit
S
Bhunia
Dhananjay
D
Dey
Alakesh
A
Bisai