The use of pre- or postoperative antibiotics in surgery for appendicitis: a systematic review.
OBJECTIVE
The aim of this study was to review the literature regarding the use of pre- and/or postoperative antibiotics in the management of appendicitis, using data obtained from PubMed and the Cochrane Library.


METHODS
A literature search was conducted using the terms "appendicitis" combined with "antibiotics." Studies were selected based on relevance for the evidence on prophylactic and postoperative treatment with regard to the route and duration of drug administration and the findings of surgery.


RESULTS
Patients with acute appendicitis should receive preoperative, broad-spectrum antibiotics. The use of postoperative antibiotics is only recommended in cases of perforation, and treatment should then be given intravenously, for a minimum period of 3-5 days for adult patients, until clinical signs such as fever resolve and laboratory parameters such as C-reactive protein curve and white blood cell (WBC) start to decline.


CONCLUSIONS
Preoperative antibiotic prophylaxis is recommended in all patients with acute appendicitis, whereas postoperative antibiotics only in cases of perforation.
Department of Surgical Sciences, Uppsala University, University Hospital, Uppsala, Sweden.
K
K
Daskalakis
C
C
Juhlin
L
L
Påhlman
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001062:Appendectomy; D001064:Appendicitis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D011182:Postoperative Care / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents
Acute appendicitis; antibiotic prophylaxis; antibiotic treatment; appendectomy; intravenous antibiotics; oral antibiotics; perforated appendicitis