Clinical features and factors associated with outcomes of patients infected with a Novel Influenza A (H7N9) virus: a preliminary study.
OBJECTIVE
The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection.


METHODS
The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses.


RESULTS
The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3(+), CD4(+), CD8(+), and CD45(+) T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively).


CONCLUSIONS
Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection.
Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China ; Key Laboratory of Infectious Diseases of State Administration of Traditional Chinese Medicine (Clinical base), Shanghai, China.
Xiaorong
X
Chen
Zongguo
Z
Yang
Yunfei
Y
Lu
Qingnian
Q
Xu
Qiang
Q
Wang
Liang
L
Chen
D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000472:pathogenicity*; D007251:Influenza, Human; D016015:Logistic Models; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D009211:Myoglobin / Q000378:metabolism
D009211:Myoglobin; D002097:C-Reactive Protein; D003404:Creatinine