Perspective on emergence and re-emergence of amantadine resistant influenza A viruses in domestic animals in China.
In China, approximately 20% of the animal original influenza A viruses have molecular markers of amantadine resistance. Through phylogenetic data analyses and geospatial statistical analyses, this study suggests emergence of amantadine resistance in animal influenza could be due to selection pressures in China, for example, amantadine usage in some areas.
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 300045, China; Pathogen Diagnostic Center, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China; Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, MS 39762, USA. Electronic address: wan@cvm.msstate.edu.
Xiu-Feng
XF
Wan
Margaret
M
Carrel
Li-Ping
LP
Long
Alisa P
AP
Alker
Mike
M
Emch
D000547:Amantadine / Q000627:therapeutic use*; D000818:Animals; D000829:Animals, Domestic / Q000821:virology*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002681:China; D024882:Drug Resistance, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology; D010802:Phylogeny; D012641:Selection, Genetic
D000998:Antiviral Agents; D000547:Amantadine
Amantadine resistance; Animal origin influenza A virus; Drug resistance; Geospatial analysis; Influenza A virus; Phylogenetic analysis