Dietary exposure to trace elements and radionuclides: the methodology of the Italian Total Diet Study 2012-2014.
This article presents the methodology of the Italian Total Diet Study 2012-2014 aimed at assessing the dietary exposure of the general Italian population to selected nonessential trace elements (Al, inorganic As, Cd, Pb, methyl-Hg, inorganic Hg, U) and radionuclides (40K, 134Cs, 137Cs, 90Sr). The establishment of the TDS food list, the design of the sampling plan, and details about the collection of food samples, their standardized culinary treatment, pooling into analytical samples and subsequent sample treatment are described. Analytical techniques and quality assurance are discussed, with emphasis on the need for speciation data and for minimizing the percentage of left-censored data so as to reduce uncertainties in exposure assessment. Finally the methodology for estimating the exposure of the general population and of population subgroups according to age (children, teenagers, adults, and the elderly) and gender, both at the national level and for each of the four main geographical areas of Italy, is presented.
Dipartimento di Sanità Pubblica Veterinaria e Sicurezza Alimentare, Istituto Superiore di Sanità, Rome, Italy.
Marilena
M
D'Amato
Aida
A
Turrini
Federica
F
Aureli
Gabriele
G
Moracci
Andrea
A
Raggi
Eugenio
E
Chiaravalle
Michele
M
Mangiacotti
Telemaco
T
Cenci
Roberta
R
Orletti
Loredana
L
Candela
Alessandra
A
di Sandro
Francesco
F
Cubadda
D000293:Adolescent; D000328:Adult; D003625:Data Collection; D004032:Diet; D004034:Diet Surveys; D005504:Food Analysis; D006801:Humans; D007558:Italy; D011786:Quality Control; D011868:Radioisotopes / Q000032:analysis*; D018570:Risk Assessment; D014131:Trace Elements / Q000032:analysis*
D011868:Radioisotopes; D014131:Trace Elements