Chemical constituents from the roots of Ranunculus ternatus and their inhibitory effects on Mycobacterium tuberculosis.
Two new benzophenones, methyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate (1) and n-butyl (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxyphenyl]-2-hydroxypropanoate (2), were isolated from the roots of Ranunculus ternatus along with the two known compounds vanillic acid (3) and gallic acid (4). Their structures were elucidated by physical and spectroscopic analysis. In addition, compound 1 exhibited obvious activity against tuberculosis, while the activity of a 1:1 mixture of compound 1 plus 4 is better than that of 1 alone.
Beijing University of Chinese Medicine, Beijing 100029, China. jzxiongying@126.com.
Ke-Zhong
KZ
Deng
Ying
Y
Xiong
Bin
B
Zhou
Yong-Mei
YM
Guan
Yong-Ming
YM
Luo
D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031947:Ranunculus / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000995:Antitubercular Agents; D004365:Drugs, Chinese Herbal; D011422:Propionates