Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.
The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.
Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
Sivakoteswara Rao
SR
Mandadapu
Mallikarjuna Reddy
MR
Gunnam
Anushka C
AC
Galasiti Kankanamalage
Roxanne Adeline Z
RA
Uy
Kevin R
KR
Alliston
Gerald H
GH
Lushington
Yunjeong
Y
Kim
Kyeong-Ok
KO
Chang
William C
WC
Groutas
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D017250:Caliciviridae Infections / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D062105:Molecular Docking Simulation; D029322:Norovirus / Q000187:drug effects* / Q000201:enzymology; D063065:Organophosphonates / Q000737:chemistry* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D063065:Organophosphonates; D011480:Protease Inhibitors
Inhibitors; Norovirus 3CL protease; Transition state mimics; α-Hydroxyphosphonates