Modeling potential time to event data with competing risks.
Patients receiving radical prostatectomy are at risk of metastasis or prostate cancer related death, and often need repeated clinical evaluations to determine whether additional adjuvant or salvage therapies are needed. Since the prostate cancer is a slowly progressing disease, and these additional therapies come with significant side effects, it is important for clinical decision making purposes to estimate a patient's risk of cancer metastasis, in the presence of a competing risk by death, under the hypothetical condition that the patient does not receive any additional therapy. In observational studies, patients may receive additional therapy by choice; the time to metastasis without any therapy is often a potential outcome and not always observed. We study the competing risks model of Fine and Gray (J Am Stat Assoc, 94:496-509, 1999) with adjustment for treatment choice by inverse probability censoring weighting (IPCW). The model can be fit using standard software for partial likelihood with double IPCW weights. The proposed methodology is used in a prostate cancer study to predict the post-prostatectomy cumulative incidence probability of cancer metastasis without additional adjuvant or salvage therapies.
Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Ave., JJN3, Cleveland, OH, 44195, USA, lil2@ccf.org.
Liang
L
Li
Bo
B
Hu
Michael W
MW
Kattan
D003131:Combined Modality Therapy; D003661:Decision Support Techniques; D018450:Disease Progression; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009362:Neoplasm Metastasis; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy; D012306:Risk; D013997:Time Factors