Practical oxazole synthesis mediated by iodine from α-bromoketones and benzylamine derivatives.
The reagent system of I2/K2CO3 could efficiently promote the oxazole synthesis from α-bromoketones and benzylamine derivatives in DMF. This method was not only suitable for 2,5-diaryl oxazole synthesis but also for 2,4,5-trisubstituted oxazole and 5-alkyl/alkenyl oxazole synthesis. Furthermore, this method was successfully applied to a one-step synthesis of a natural product halfordinol in 62% yield.
State Key Laboratory of Elemento-Organic Chemistry, The Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. zhangchi@nankai.edu.cn.
Wen-Chao
WC
Gao
Ruo-Lin
RL
Wang
Chi
C
Zhang