Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions.
An apparatus is reported for real-time Raman monitoring of reactions performed using continuous-flow processing. Its capability is assessed by studying four reactions, all involving formation of products bearing α,β-unsaturated carbonyl moieties; synthesis of 3-acetylcoumarin, Knoevenagel and Claisen-Schmidt condensations, and a Biginelli reaction. In each case it is possible to monitor the reactions and also in one case, by means of a calibration curve, determine product conversion from Raman spectral data as corroborated by data obtained using NMR spectroscopy.
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269, USA.
Trevor A
TA
Hamlin
Nicholas E
NE
Leadbeater
Raman spectroscopy; flow processing; reaction monitoring; α,β-unsaturated carbonyl