Endoscopic laser dichorionization of the placenta in the treatment of severe twin-twin transfusion syndrome.
OBJECTIVE
To describe the results of a technique of laser ablation of placental vessels in the treatment of severe twin-twin transfusion syndrome (TTTS), which is characterized by separation of the fetoplacental vascular territories and dichorionization of the placenta.


METHODS
Descriptive analysis of TTTS cases treated with the endoscopic laser dichorionization of the placenta (ELDP) procedure. The variables evaluated were the occurrence of reversal of the donor-recipient phenotype, persistence of TTTS or twin anemia-polycythemia sequence (TAPS); gestational age at delivery; discharge from the hospital of at least 1 or 2 live neonates, and incidence of neurological alterations among survivors.


RESULTS
67 patients were treated with the ELDP procedure. There was no persistence of TTTS, reversal of the donor-recipient phenotype or TAPS. The median gestational age at delivery was 33.0 (23.6-37.7) weeks. The rate of discharge from the hospital of at least 1 or 2 live neonates was 88.2% (67/76) and 71.1% (54/76), respectively. Among survivors, 17 (17/121 = 14.0%) children presented with neurodevelopmental alterations during clinical follow-up.


CONCLUSIONS
The major contribution of this study was the demonstration that the ELDP technique appears to be associated with a low risk of persistence or recurrence of TTTS and TAPS.
Department of Obstetrics and Gynecology, Professor José Aristodemo Pinotti Hospital, Center for Integral Assistance to Women's Health, State University of Campinas (UNICAMP), Campinas, Brazil.
Cleisson F A
CF
Peralta
Francisca S
FS
Molina
Luisa F
LF
Gómez
João R
JR
Bennini
Orlando
O
Gomes Neto
Ricardo
R
Barini
D002823:Chorion / Q000098:blood supply* / Q000601:surgery*; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005330:Fetofetal Transfusion / Q000150:complications / Q000601:surgery*; D005332:Fetoscopy / Q000009:adverse effects / Q000379:methods; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology; D010920:Placenta / Q000098:blood supply* / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies