Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure.
OBJECTIVE
We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).


METHODS
We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.


RESULTS
Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.


CONCLUSIONS
Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility.
Department of Cardiovascular Medicine, Department of Emergency Medicine and the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Queen
Q
Henry-Okafor
Sean P
SP
Collins
Cathy A
CA
Jenkins
Karen F
KF
Miller
David J
DJ
Maron
Allen J
AJ
Naftilan
Neal
N
Weintraub
Gregory J
GJ
Fermann
John
J
McPherson
Santosh
S
Menon
Douglas B
DB
Sawyer
Alan B
AB
Storrow
Acute heart failure; b-type natriuretic peptide; prognostic outcomes; uric acid