Solid state characterisation of silver sulfadiazine loaded on montmorillonite/chitosan nanocomposite for wound healing.
Biopolymer chitosan/montmorillonite nanocomposites loaded with silver sulfadiazine for wound healing purposes were prepared via intercalation solution technique. Structure and morphology of loaded nanocomposites were studied and compared with pure components and unloaded nanocomposites. X-ray diffraction, Fourier transformed infrared spectroscopy, high resolution transmission electron microscopy coupled with energy-dispersion X-ray analysis, thermal and elemental analysis were employed for the characterisation. The results confirmed that the drug was effectively loaded in the three-dimensional nanocomposite structures, in which chitosan chains were adsorbed in monolayers into the clay mineral interlayer spaces.
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, s/n, 18071 s/n Granada, Spain.
Carola
C
Aguzzi
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Giuseppina
G
Sandri
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Cristina
C
Bonferoni
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, s/n, 18071 s/n Granada, Spain.
Pilar
P
Cerezo
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Silvia
S
Rossi
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Franca
F
Ferrari
Department of Drug Sciences, University of Pavia, viale Taramelli 12, 27100 Pavia, Italy.
Carla
C
Caramella
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, s/n, 18071 s/n Granada, Spain; Andalusian Institute of Earth Sciences, CSIC-University of Granada, Avda. de Las Palmeras 4, 18100 Armilla (Granada), Spain. Electronic address: cviseras@ugr.es.
César
C
Viseras
D001546:Bentonite / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D012837:Silver Sulfadiazine / Q000737:chemistry* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
D001546:Bentonite; D048271:Chitosan; D012837:Silver Sulfadiazine
Chitosan; Montmorillonite; Nanocomposites; Silver sulfadiazine; Solid state characterisation