Quadruply hydrogen-bonded heteroduplexes based on imide and urea units arrayed with ADDA/DAAD sequences.
A new class of imide- and urea-based hetero-strands with a quadruple ADDA/DAAD hydrogen-bond array was designed and synthesized from easily accessible starting materials. The molecular recognition between the two different strands depends highly on the substituents and the linker between neighboring hydrogen-bonds, which results in the stability of these heteroduplexes varying from 10(3) to >10(5) M(-1) in apolar solvents. In particular, an increase of the association constant by up to one order of magnitude was observed by derivatizing the ADDA arrays at the termini with electron-withdrawing groups. Molecular modelling of the representative complementary complexes reveals the binding mode of four hydrogen-bond arrays that agrees with the matched pair.
College of Chemistry, Sichuan University, Chengdu 610064, China. lhyuan@scu.edu.cn.
Xianghui
X
Li
Yiming
Y
Jia
Yi
Y
Ren
Youjia
Y
Wang
Jinchuan
J
Hu
Teng
T
Ma
Wen
W
Feng
Lihua
L
Yuan