Genetic markers for cardiovascular disease in psoriasis: the missing piece.
Psoriasis is a common, chronic inflammatory disease associated with serious comorbidities. Severe psoriasis has been associated with increase cardiovascular mortality, due to a higher prevalence of traditional cardiovascular risk factors such as diabetes, hypertension, dyslipidemia and obesity, and premature atherosclerosis, as a consequence of its systemic inflammation. It is likely that there are genetic links between psoriasis, its comorbidities and cardiovascular disease. Although there are some studies performed in rheumatoid arthritis reporting some gene polymorphisms that may be associated with cardiovascular diseases and comorbidities these studies are lacking in psoriasis. Recognizing genetic markers that could predict which patients are at risk of developing psoriasis-linked cardiovascular comorbidities would facilitate screening strategies and permit an earlier management of cardiovascular risk factors, with important clinical implications.
Tiago
T
Torres
Andrea
A
Chiricozzi
Sergio
S
Chimenti
Rosita
R
Saraceno
D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D011379:Prognosis; D011565:Psoriasis / Q000150:complications* / Q000235:genetics*; D012307:Risk Factors
D005819:Genetic Markers