Evolutionarily conserved motifs and modules in mitochondrial protein-protein interaction networks.
Advances in organelle interactomics have led to new insights into organelle functions. In this study, we considered the common mitochondrial PIN of four evolutionarily distant eukaryotic species, namely Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans. By comparative interactomics analysis of mitochondrial PINs in these organisms, five conserved modules were identified. Modules comprise the main mitochondrial tasks, including proteins involved in translation process, mitochondrial import inner membrane proteins, TCA cycle enzymes, mitochondrial electron transport chain, and metabolic enzymes. Furthermore, we reemphasize that subgraphs of network, i.e., motifs and themes, may represent evolutionarily conserved topological units which are biologically significant.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: mjafari@ipm.ir.
Mohieddin
M
Jafari
Mehdi
M
Sadeghi
Mehdi
M
Mirzaie
Sayed-Amir
SA
Marashi
Mostafa
M
Rezaei-Tavirani
D000465:Algorithms; D005075:Biological Evolution; D017124:Conserved Sequence; D024101:Mitochondrial Proteins / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
D024101:Mitochondrial Proteins; D011506:Proteins
Comparative interactomics; Evolution; Mitochondria; OP; Organelle interactomics; PIN; orthologous protein; protein interaction network