[The relationship between hyperinsulinemia and hypokalemic periodic paralysis in overweight/obesity subjects].
OBJECTIVE
To study the relationship between hyperinsulinemia and primary periodic paralysis in overweight/obesity people.


METHODS
Overweight/obesity people with primary hypokalemic periodic paralysis were administrated as disease group. Serum potassium, insulin and glucose were analyzed at different time (0 h, 1 h, 2 h, 3 h, 4 h) after taking 100 g carbohydrates and the results were compared with that of control group matched by gender, age and body mass index (BMI).


RESULTS
(1) Males were much more than females in disease group (14 males and 2 females), the onset age ranged from 20 to 50 years old. (2) Both the highest insulin level and the lowest potassium level appeared at one hour after taking the carbohydrates. And the highest insulin level of disease group was significant higher than that of control group. (3) The area under the curve of insulin and insulin/potassium of disease group was significant higher than that of control group.


CONCLUSIONS
The postprandial hyperinsulinemia was an important factor in overweight/obesity people with hypokalemic periodic paralysis.
Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Dong-Mei
DM
Chen
Ye-Rong
YR
Yu
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications*; D020514:Hypokalemic Periodic Paralysis / Q000150:complications*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D011188:Potassium / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin; D011188:Potassium