[The role of glucagon-like peptide-1 and its receptor in the mechanism of metabolic surgery].
At present, surgery has become one of the treatments for type 2 diabetes, but it is still unclear about the therapeutic mechanism. Many experiments has proved that the anatomical and physiological structure has been altered leading to significant changes related to the secretion of gastrointestinal hormones and neuropeptides. These molecular are related to the metabolism of glucose, functions of islet cells and sensitivity of insulin. Intensive studies of glucagon-like peptide-1 (GLP-1) play an important role in the surgical treatment of diabetes and now it has gained increasing recognition. However, GLP-1 must be combined with GLP-1 receptor (GLP-1R) to execute its function. In this paper we reviewed the role of GLP-1 and its receptor in the mechanism of metabolic surgery.
Department of Endoscopy Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. xfzheng818@hotmail.com.
Zhi-hai
ZH
Zheng
Xiao-kun
XK
Wang
Heng-liang
HL
Zhu
Xiao-feng
XF
Zheng
Fei-zhao
FZ
Jiang
D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D052216:Glucagon-Like Peptide 1; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D018027:Receptors, Glucagon
C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1