Effect of acetohydroxamic acid on dissolution of canine struvite uroliths.
Long-term administration of acetohydroxamic acid to dogs with experimentally induced urease-positive staphylococcal urinary tract infections and struvite urolithiasis resulted in dose-dependent inhibition of urolith growth or urolith dissolution. Inhibition of urolith growth was associated with drug dose-dependent reduction of urine urease activity, urine pH, crystalluria, pyuria, hematuria, and proteinuria. Lesions of the urinary tract of dogs treated with acetohydroxamic acid were less severe than those of control dogs. Dose-dependent adverse drug reactions included reversible hemolytic anemia, abnormal red cell morphology, and abnormalities of bilirubin metabolism.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA.
D R
DR
Krawiec
C A
CA
Osborne
J R
JR
Leininger
D P
DP
Griffith
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017616:Magnesium Compounds / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D000069877:Struvite; D001744:Urinary Bladder Calculi / Q000188:drug therapy / Q000662:veterinary*; D014552:Urinary Tract Infections / Q000662:veterinary
D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D017616:Magnesium Compounds; D010710:Phosphates; C006358:acetohydroxamic acid; D000069877:Struvite