[Study on solubility of ginkgolide components with mass fraction weight coefficient method].
In this study, the HPLC-ELSD method was adopted to detect the equilibrium solubility of B and A in water and different pH buffer solution, as well as their apparent oil-water partition coefficients in the noctanol-water/buffer solution. Furthermore, the mass fraction weight coefficient method was adopted to express the integrated equilibrium solubility and oil-water distribution coefficient of ginkgolide components. The direct addition method and the mass fraction weight coefficient method were compared in calculating the property value of ginkgolide components, showing that the mass fraction weight coefficient method was more scientific and reasonable. The tentative study provided ideas to property characterization of traditional Chinese medicine components, as well as basis for studies on preparations of traditional Chinese medicine components.
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. liudan0513@yeah.net
Dan
D
Liu
Xiao-Bin
XB
Jia
Wei
W
Xiao
D046934:Ginkgolides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008516:Medicine, Chinese Traditional; D012995:Solubility
D046934:Ginkgolides