Outbreak of multidrug-resistant acute postoperative endophthalmitis due to Enterobacter aerogenes.
OBJECTIVE
To report the clinical features, management, and outcome of 7 cases of culture-proven multidrug-resistant Enterobacter postoperative endophthalmitis following cataract surgery.


METHODS
Medical records of 7 cases of acute postoperative endophthalmitis after uneventful cataract surgery were reviewed. Details regarding age, gender, visual acuity and clinical features at presentation, microbiological profile, treatment interventions, and visual acuity and clinical features at 1 week, 1 month, and 3 months follow-up were collected.


RESULTS
All patients reported decreased visual acuity and pain as presenting symptoms. All patients were resistant to intravitreal antibiotics such as vancomycin (1 mg/0.1 mL) and ceftazidime (2.25 mg/0.1 mL). Culture of aqueous and vitreous sample was positive for Enterobacter aerogenes and sensitive to co-trimoxazole, cefoperazone-sulbactam, imipenem-meropenem, and piperacillin-tazobactem. Two patients with panophthalmitis and no perception of light underwent evisceration. Three patients had visual acuity of ≥6/24 at the final follow-up.


CONCLUSIONS
Multidrug-resistant Enterobacter acute postoperative endophthalmitis has a poor prognosis if not intercepted early.
Department of Ophthalmology and.
Shailaja S
SS
Bhat
Vivekanand
V
Undrakonda
Chiranjay
C
Mukhopadhyay
Prachi Vikramsinh
PV
Parmar
D000328:Adult; D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D024901:Drug Resistance, Multiple, Bacterial; D009877:Endophthalmitis / Q000453:epidemiology* / Q000382:microbiology; D021902:Enterobacter aerogenes / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000382:microbiology