[Vitamin D and pregnancy].
Vitamin D insufficiency is characterized, since 2005, by 25(OH)D concentration less than 75 nmol/L (or 30 ng/mL). Vitamin D could interfere with many mechanisms involved in preeclampsia's pathogenesis including trophoblastic invasion and immunomodulation as well as blood pressure control and proteinuria. Occurrence of preeclampsia and gestational diabetes seems to be linked to vitamin D deficiency but recent data in the literature are contradictory. Vitamin D supplementation during pregnancy is controversial. Some societies consider it unnecessary and others recommend up to 2000 UI/d. There is no reported case of teratogenicity linked with vitamin D intake.
AP-HP, hôpital Antoine-Béclère, université Paris-Sud, service de gynécologie obstétrique et médecine de la reproduction, 92141 Clamart, France; PremUP, 75014 Paris, France. Electronic address: alexandra.benachi@abc.aphp.fr.
Alexandra
A
Benachi
Anne-Gael
AG
Cordier
Marie
M
Courbebaisse
Jean-Claude
JC
Souberbielle
D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D016585:Vaginosis, Bacterial / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D014807:Vitamin D / Q000097:blood / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
D014807:Vitamin D