Acute myeloid leukemia and colon carcinoma during the course of acromegaly.
We describe the case of a 70-year-old male with acromegaly who developed colon carcinoma and myelodysplastic syndrome (MDS) during the course of acromegaly. MDS progressed to acute myeloid leukemia, but was refractory to chemotherapy. Acromegaly is a rare disorder caused by excessive amounts of growth hormone (GH) primarily secreted by pituitary adenomas. Patients with acromegaly are more prone to develop various malignancies, but there are few reports of hematological malignancies in such patients. In the present case, excessive endogenous GH and insulin-like growth factor-I levels may have altered cell proliferation and thereby affected the oncogenesis and chemosensitivity of both malignancies.
Department of Hematology and Oncology, Konan Kosei Hospital, 137 Oomatsubara, Takaya-cho, Konan-city, Aichi, 483-8704, Japan, k-ozeki@konan.jaaikosei.or.jp.
Kazutaka
K
Ozeki
Yoshihisa
Y
Morishita
Sigeki
S
Saito
Koji
K
Umemura
Yohei
Y
Yamaguchi
Shotaro
S
Tatekawa
Koichi
K
Watamoto
Akio
A
Kohno
Tsuyoshi
T
Nogimori
D000172:Acromegaly / Q000150:complications* / Q000209:etiology; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D020685:Colonoscopes; D018450:Disease Progression; D017809:Fatal Outcome; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis; D016896:Treatment Outcome
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I