The differential diagnosis of systemic sclerosis.
OBJECTIVE
The new American College of Rheumatology/European League Against Rheumatism classification criteria will enable earlier diagnosis and, therefore, the use of newer treatment modalities for systemic sclerosis (SSc). It is therefore critical to exclude non-SSc causes for diffuse skin thickening as early as possible.


RESULTS
The recently described gadolinium-induced nephrogenic systemic fibrosis may mimic SSc as may other conditions which require a different treatment strategy. Recently, treatment with immunoablation and autologous stem cell transplantation has been shown to significantly benefit some patients with conditions such as scleromyxoedema and SSc. The more accurate measurement of SSc-specific autoantibodies such as topoisomerase 1, centromere and RNA polymerase has recently allowed a more precise subclassification of SSc with implications for treatment and prognosis.


CONCLUSIONS
Skin thickening is a nonspecific manifestation of many different processes including (rarely) early scleroderma, which is mostly symmetrical and associated with Raynaud's phenomenon, nailfold capillaroscopic changes and antinuclear antibodies. If the latter three factors are absent, then other conditions must be excluded, the commonest being eosinophilic fasciitis. Skin biopsy (looking for eosinophil infiltration, increased mucin or amyloid deposition), SSc-specific autoantibodies or paraproteins in blood and a careful medical history and system screening will exclude nonscleroderma conditions.
aDepartment of Rheumatology bDepartment of Dermatology, University Hospital Basel, Basel, Switzerland.
Alan
A
Tyndall
Susanna
S
Fistarol
D003240:Connective Tissue Diseases / Q000175:diagnosis; D003937:Diagnosis, Differential; D004802:Eosinophilia; D006801:Humans; D054989:Nephrogenic Fibrosing Dermopathy / Q000175:diagnosis; D012592:Scleredema Adultorum / Q000175:diagnosis; D012594:Scleroderma, Localized / Q000175:diagnosis; D012595:Scleroderma, Systemic / Q000175:diagnosis*; D053718:Scleromyxedema / Q000175:diagnosis; D013585:Synovitis / Q000175:diagnosis