Serum adiponectin, anemia and left ventricular dimensions in patients with cardiac cachexia.
OBJECTIVE
Our study aims to determine the role of serum adiponectin in chronic heart failure (CHF) and cardiac cachexia (CC).


METHODS
Ninety consecutive patients were included in the study. Patients were divided into three groups: 30 CHF patients with CC, 30 CHF patients without CC, and 30 healthy individuals. Adiponectin levels were measured through human ELISA kits.


RESULTS
Levels of serum adiponectin were significantly higher in the CHF patients with cachexia in comparison with the other groups (CHF with CC: 58.4 ± 15.5 ng/ml vs. CHF without CC: 24 ± 6.7 ng/ml and controls: 7.7 ± 3.4 ng/ml; p = 0.001). Serum adiponectin was negatively correlated with BMI, high-sensitivity C-reactive protein, and hemoglobin (r = -0.37, p = 0.02; r = -0.29, p = 0.02; r = -0.18, p = 0.03, respectively) in the CHF patients with cachexia. Additionally, serum adiponectin levels were positively correlated with B-type natriuretic protein levels, left ventricle end-diastolic and end-systolic diameters (r = 0.36, p = 0.02; r = 0.46, p = 0.01; r = 0.49, p = 0.006, respectively) in the CHF patients with cachexia.


CONCLUSIONS
Our findings suggest that adiponectin may play a critical role in the pathogenesis of cardiac remodeling and anemia in CC.
Department of Cardiology, Baltalimani Bone Diseases Education and Research Hospital, Istanbul, Turkey.
Evin
E
Bozcali
Veli
V
Polat
Handan
H
Akbulut
Mustafa
M
Ferzeyn Yavuzkir
Ilgin
I
Karaca
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000740:Anemia / Q000097:blood* / Q000209:etiology; D002100:Cachexia / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D020257:Ventricular Remodeling
D052242:Adiponectin