Interleukin-23 receptor genetic variants contribute to susceptibility of multiple cancers.
OBJECTIVE
Interleukin-23 (IL-23) and IL-23 receptor (IL23R) play an important role during the T-helper 17 (Th17) cell-mediated inflammatory process as well as pathogenesis of multiple cancers. Several IL-23R single nucleotide polymorphisms (SNPs), especially rs6682925, rs10889677 and rs1884444 polymorphisms, are considered to have significant impacts on susceptibility of multiple cancers. A number of case-control studies have explored the role these genetic polymorphisms in development of carcinogenesis, but the conclusions are inconsistent. Therefore, we conducted this meta-analysis to systematically investigate the associations between the three genetic variants and multiple cancer risk.


METHODS
A total of ten studies are eligible (12,211 patients and 14,650 controls). Pooled odds ratios (ORs) and the 95% confidence interval (95% CI) were appropriately calculated using either fixed-effect model or random-effect model.


RESULTS
Significant associations between rs6682925 or rs10889677 polymorphism and cancer risk were found (OR=1.11, 95% CI=1.03-1.21, P=0.007; or OR=0.85, 95% CI=0.71-0.92, P=0.001). However, there was no such association between rs1884444 genotypes and cancer susceptibility (P>0.05).


CONCLUSIONS
These findings reveal that the IL-23R rs6682925 and rs10889677 genetic variants play a more important part in pathogenesis of multiple cancers.
Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China.
Jiarui
J
Yao
Li
L
Liu
Ming
M
Yang
D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*
C515500:IL23R protein, human; D018123:Receptors, Interleukin
3′-UTR; 3′-untranslated region; 95% CI; 95% confidence interval; Cancer; HWE; Hardy–Weinberg equilibrium; IL-23; IL-23R; IL23R; Interleukin-23 receptor; MAF; Meta-analysis; OR; Polymorphism; SNP; Susceptibility; T-helper 17; Th17; interleukin-23; minor allele frequency; odds ratios; single nucleotide polymorphism