Skull metastasis from intrahepatic cholangiocarcinoma: report of 3 cases and review of the literature.
Skull metastases occur in patients with various malignancies; however, those resulting from intrahepatic cholangiocarcinoma (ICC) have been rarely reported. In our hospital, 324 patients were diagnosed with metastatic brain or skull tumors from June 1969 to June 2011, but only 3 of them (0.9%) developed skull metastases from ICC. We report the case of 3 patients with skull metastases from ICC. A combination of computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI), 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and methionine-PET were used for imaging. Sites of tumors were the lateral left orbit and right parietal bone in case 1, the left parietal bone, left temporal bone, and lateral left orbit in case 2, the right petrous bone, right occipital bone, and upper cervical vertebra in case 3. The metastases were confirmed to have originated from ICC by biopsy in two of the cases and diagnosed by MRI and FDG-PET in case 2. Radiosurgery and radiotherapy had positive effects on symptom improvement and cosmetic problems.
Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University School of Medicine.
Kenji
K
Fujimoto
Jun-ichiro
J
Kuroda
Keishi
K
Makino
Yu
Y
Hasegawa
Jun-ichi
J
Kuratsu
D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000473:pathology* / Q000601:surgery; D002574:Cervical Vertebrae / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009777:Occipital Bone / Q000473:pathology*; D009918:Orbital Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D010579:Petrous Bone / Q000473:pathology*; D049268:Positron-Emission Tomography; D016634:Radiosurgery; D012888:Skull Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D013125:Spinal Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D014057:Tomography, X-Ray Computed