Stem Cells for Neurovascular Repair in Stroke.
Stem cells exert therapeutic effects against ischemic stroke via transplantation of exogenous stem cells or stimulation of endogenous stem cells within the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this paper, we review the different sources of stem cells that have been tested in animal models of stroke. In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for ischemic stroke.
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd. MDC78, Tampa, Florida 33612, USA.
Kazutaka
K
Shinozuka
Travis
T
Dailey
Naoki
N
Tajiri
Hiroto
H
Ishikawa
Dae Won
DW
Kim
Mibel
M
Pabon
Sandra
S
Acosta
Yuji
Y
Kaneko
Cesar V
CV
Borlongan
Blood brain barrier; Cell-based therapies; Cerebral ischemia; Endothelial cells; Vasculature