Nociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex.
BACKGROUND
The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness.


OBJECTIVE
To identify correlations between cerebral glucose metabolism and NCS-R total scores.


METHODS
[18F]-fluorodeoxyglucose positron emission tomography, NCS-R, and Coma Recovery Scale-Revised assessments were performed in 49 patients with disorders of consciousness.


RESULTS
We identified a significant positive correlation between NCS-R total scores and metabolism in the posterior part of the anterior cingulate cortex, known to be involved in pain processing. No other cluster reached significance. No significant effect of clinical diagnosis (vegetative/unresponsive vs minimally conscious states), etiology or interval since insult was observed.


CONCLUSIONS
Our data support the hypothesis that the NCS-R total scores are related to cortical processing of nociception and may constitute an appropriate behavioral tool to assess, monitor, and treat possible pain in brain-damaged noncommunicative patients with disorders of consciousness. Future studies using event-related functional magnetic resonance imaging should investigate the correlation between NCS-R scores and brain activation in response to noxious stimulation at the single-subject level.
1University of Liège, Liège, Belgium.
Camille
C
Chatelle
Aurore
A
Thibaut
Marie-Aurélie
MA
Bruno
Mélanie
M
Boly
Claire
C
Bernard
Roland
R
Hustinx
Caroline
C
Schnakers
Steven
S
Laureys
D000328:Adult; D003244:Consciousness Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D059225:Nociception / Q000502:physiology*; D010146:Pain / Q000175:diagnosis; D010147:Pain Measurement / Q000379:methods*; D049268:Positron-Emission Tomography
D019788:Fluorodeoxyglucose F18
Nociception Coma Scale–Revised; anterior cingulate cortex; brain metabolism; disorders of consciousness; pain assessment; pain matrix