Allosteric modulation of A1-adenosine receptor: a review.
Allosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased. Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, this class of compounds has therapeutic potential as analgesics and neuroprotective agents.
María
M
Kimatrai-Salvador
Pier Giovanni
PG
Baraldi
Romeo
R
Romagnoli
D000494:Allosteric Regulation; D000818:Animals; D002626:Chemistry, Pharmaceutical; D006801:Humans; D043682:Receptor, Adenosine A1 / Q000378:metabolism*
D043682:Receptor, Adenosine A1