Divergent Reaction Pathways for Phenol Arylation by Arynes: Synthesis of Helicenes and 2-Arylphenols.
Two reactions of phenols with arynes have been developed. If LiTMP base is employed, arynes generated from aryl chlorides react with phenols to form helicenes.o-Arylation of phenols can be achieved by employingtBuONa base in the presence of AgOAc. Direct arylation of binol was achieved leading to the shortest pathway to o,o'-diarylbinols.
Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA.
Thanh
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Truong
Olafs
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Daugulis