[Vitamin D and infectious diseases].
Vitamin D plays a role in the synthesis of antibacterial peptids and in autophagy. Several studies have shown that low levels of vitamin D are associated with the susceptibility and the severity of acute infections on one hand, and with an unfavorable outcome of some chronic infections (such as HIV infection). Vitamin D supplementation improves response to treatment of some viral (such as chronic hepatitis C infection) or bacterial infections (such as pulmonar tuberculosis). Vitamin D supplementation demonstrated no benefit in reducing the incidence of pulmonary infections. The target level of vitamin D to be reached after supplementation is not known yet.
Hôpital universitaire Hôtel-Dieu, unité fonctionnelle de thérapeutique en immuno-infectiologie, centre de diagnostic et de thérapeutique, 75004 Paris, France; Université Paris Descartes, faculté de médecine, EA 3620, site Necker, 75015 Paris, France.
Jade
J
Ghosn
Jean-Paul
JP
Viard
D000917:Antibody Formation / Q000502:physiology; D002908:Chronic Disease / Q000453:epidemiology / Q000628:therapy; D003141:Communicable Diseases / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology*; D004198:Disease Susceptibility; D006801:Humans; D007109:Immunity / Q000502:physiology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014611:Vaccination; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood / Q000502:physiology*; D014808:Vitamin D Deficiency / Q000178:diet therapy / Q000453:epidemiology* / Q000276:immunology
D014807:Vitamin D