Roles of Rho GTPases in leucocyte and leukaemia cell transendothelial migration.
Leucocytes migrate into and out of blood vessels at multiple points during their development and maturation, and during immune surveillance. In response to tissue damage and infection, they are rapidly recruited through the endothelium lining blood vessels into the tissues. Leukaemia cells also move in and out of the bloodstream during leukaemia progression. Rho GTPases are intracellular signalling proteins that regulate cytoskeletal dynamics and are key coordinators of cell migration. Here, we describe how different members of the Rho GTPase family act in leucocytes and leukaemia cells to regulate steps of transendothelial migration. We discuss how inhibitors of Rho signalling could be used to reduce leucocyte or leukaemia cell entry into tissues.
Randall Division of Cell and Molecular Biophysics, King's College London, , New Hunt's House, Guy's Campus, London SE1 1UL, UK.
Elvira
E
Infante
Anne J
AJ
Ridley
D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D007938:Leukemia / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins
Rho GTPases; actin cytoskeleton; cell migration; endothelial cells; leucocytes