[Family-based association study of a variable number of tandem repeat polymorphism of DAT1 gene with Tourette syndrome in a Chinese Han population].
OBJECTIVE
To assess the association of a 40 bp variable number of tandem repeat (VNTR) polymorphism within 3 untranslated region of dopamine transporter gene (DAT1) with Tourette syndrome (TS) in a Chinese Han population.


METHODS
A total of 160 TS patients and their parents were recruited. The VNTR polymorphism was detected with polymerase chain reaction-VNTR analysis, and its association with TS and its subtypes were assessed through a family-based association study comprising transmission disequilibrium test (TDT) and haplotype relative risk (HRR) analysis.


RESULTS
The repeat numbers at the DAT1 40 bp locus were 11, 10, 9, 7.5 and 7 among the patients and their parents, with the most common type being a 10-repeat allele. No significant association was detected between the polymorphism and TS (TDT: X ² = 0.472, df = 1, P = 0.583; HRR: X ² = 0.313, P = 0.576, OR = 0.855, 95%CI: 0.493-1.481).


CONCLUSIONS
Our data suggested that the VNTR polymorphism of DAT1 gene is not associated with susceptibility to TS in Chinese Han population. However, our results are to be validated in larger sets of patients collected from other populations.
Shandong Provincial Key Laboratory of Metabolic Disease, Genetic Laboratory, Department of Psychiatry, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong 266003, P. R. China. Email: liushiguo2002@126.com.
Lanlan
L
Zheng
Zhen-liang
ZL
Han
Xin-hua
XH
Zhang
Xue-qin
XQ
Wang
Wei-hua
WH
Jiang
Ming-ji
MJ
Yi
Shi-guo
SG
Liu
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D010375:Pedigree; D011110:Polymorphism, Genetic; D005879:Tourette Syndrome / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human