Fast and green one-pot multicomponent synthesis of a library of pyrrolo [1,2-c] pyrimidines under microwave irradiation.
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
Center for Organic Chemistry "C. D. Nenitzescu", Romanian Academy, Spl. Independentei 202B, Bucharest 060023, Romania. mirelupb@gmail.com.
Emilian
E
Georgescu
Florentina
F
Georgescu
Constantin
C
Draghici
Liliana
L
Cristian
Marcel Mirel
MM
Popa
Florea
F
Dumitrascu
D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D011743:Pyrimidines; D011758:Pyrroles