[Research progress of bioreactor biophysical factors in cartilage tissue engineering].
OBJECTIVE
To review the recent research progress of the bioreactor biophysical factors in cartilage tissue engineering.


METHODS
The related literature concerning the biophysical factors of bioreactor in cartilage tissue engineering was reviewed, analyzed, and summarized.


RESULTS
Oxygen concentration, hydrostatic pressure, compressive force, and shear load in the bioreactor system have no unified standard parameters. Hydrostatic pressure and shear load have been in controversy, which restricts the application of bioreactors.


CONCLUSIONS
The biophysical factors of broreactor in cartilage tissue engineering have to be studied deeply.
Department of General Thoracic Surgery, Medical College of Yangzhou University, Yangzhou Jiangsu, 225001, P.R.China.
Gang
G
Ye
Fangbiao
F
Zhang
Hongcan
H
Shi
D000818:Animals; D001696:Biomechanical Phenomena; D019149:Bioreactors; D002356:Cartilage / Q000166:cytology / Q000502:physiology*; D002358:Cartilage, Articular / Q000166:cytology / Q000502:physiology; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D002454:Cell Differentiation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology; D006801:Humans; D006874:Hydrostatic Pressure; D040542:Mechanotransduction, Cellular / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*
D010100:Oxygen