The role of JAK-STAT signaling within the CNS.
JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopoietic cells, its role has been found critical in all cell types, including neurons. This review will focus on JAK-STAT functions in the mature central nervous system. Our recent research suggests the intriguing possibility of a non-nuclear role of STAT3 during synaptic plasticity. Dysregulation of the JAK-STAT pathway in inflammation, cancer and neurodegenerative diseases positions it at the heart of most brain disorders, highlighting the importance to understand how it can influence the fate and functions of brain cells.
MRC Centre for Synaptic Plasticity; School of Physiology and Pharmacology; University of Bristol; Bristol, UK.
Celine S
CS
Nicolas
Mascia
M
Amici
Zuner A
ZA
Bortolotto
Andrew
A
Doherty
Zsolt
Z
Csaba
Assia
A
Fafouri
Pascal
P
Dournaud
Pierre
P
Gressens
Graham L
GL
Collingridge
Stephane
S
Peineau
JAK2; NMDA receptor; STAT3; cancer; hormonal regulation; inflammation; long term depression; synaptic plasticity