Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.
Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.
Institute of Integrative traditional & western Medicine，Medical College, Yangzhou University, Yangzhou, China.
Bing Chun
BC
Yan
Joon Ha
JH
Park
Bich Na
BN
Shin
Ji Hyeon
JH
Ahn
In Hye
IH
Kim
Jae-Chul
JC
Lee
Ki-Yeon
KY
Yoo
In Koo
IK
Hwang
Jung Hoon
JH
Choi
Jeong Ho
JH
Park
Yun Lyul
YL
Lee
Hong-Won
HW
Suh
Jong-Gab
JG
Jun
Young-Guen
YG
Kwon
Young-Myeong
YM
Kim
Seung-Hae
SH
Kwon
Song
S
Her
Jin Su
JS
Kim
Byung-Hwa
BH
Hyun
Chul-Kyu
CK
Kim
Jun Hwi
JH
Cho
Choong Hyun
CH
Lee
Moo-Ho
MH
Won
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use*; D001578:Benzopyrans / Q000627:therapeutic use*; D002087:Butyrates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004338:Drug Combinations; D005455:Fluorescent Antibody Technique; D007124:Immunoenzyme Techniques; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control; D020521:Stroke / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D002087:Butyrates; D004338:Drug Combinations; D018696:Neuroprotective Agents; C101278:decursin; D001241:Aspirin