Chemical composition and biological activity of Conyza bonariensis essential oil collected in Mérida, Venezuela.
The essential oil from aerial parts of Conyza bonariensis (L) Cronquist collected in Mérida was obtained by hydrodistillation and analysed by GC/MS. The major components were trans-beta-farnesene (37.8%), trans-ocimene (20.7%) and beta-sesquiphellandrene (9.8%). Cytotoxicity assay was also performed with the essential oil against HeLa (cervix carcinoma), A-459 (lung carcinoma) and MCF-7 (breast adenocarcinoma) human cell lines and against normal Vero cells (African green monkey kidney) with IC50 values ranging from 1.4 to 45.8 microg/mL. Additionally, the essential oil presented a significant bactericidal effect against Bacillus cereus, while a moderate activity was observed against Staphylococcus epidermidis and Candida albicans.
Microbiology and Cell Biology Department, University of La Laguna, La Laguna, Tenerife, Spain.
Liliana
L
Araujo
Laila M
LM
Moujir
Janne
J
Rojas
Luis
L
Rojas
Juan
J
Carmona
María
M
Rondón
D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis*; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002522:Chlorocebus aethiops; D035401:Conyza / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D008401:Gas Chromatography-Mass Spectrometry; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry*; D014687:Venezuela; D014709:Vero Cells
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile