Zebrafish cancer and metastasis models for in vivo drug discovery.
There is a great need for more efficient methods to discover new cancer therapeutics, as traditional drug development processes are slow and expensive. The use of zebrafish as a whole-organism screen is a time and cost-effective means of improving the efficiency and efficacy of drug development. This review features zebrafish genetic and cell transplantation models of cancer and metastasis, and current imaging and automation technologies that, together, will significantly advance the field of anti-cancer drug discovery.
Jennifer
J
Tat
Mingyao
M
Liu
Xiao-Yan
XY
Wen
D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D015027:Zebrafish / Q000235:genetics