Increased prevalence of autoimmune phenomena in myelofibrosis: relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns.
Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.
U.O. Ematologia e Centro Trapianti di Midollo, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. Electronic address: wbarcel@policlinico.mi.it.
Wilma
W
Barcellini
Alessandra
A
Iurlo
Tommaso
T
Radice
Francesca Guia
FG
Imperiali
Anna
A
Zaninoni
Bruno
B
Fattizzo
Francesca
F
Guidotti
Paola
P
Bianchi
Elisa
E
Fermo
Dario
D
Consonni
Agostino
A
Cortelezzi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D003298:Coombs Test; D016207:Cytokines / Q000378:metabolism*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055728:Primary Myelofibrosis / Q000453:epidemiology / Q000276:immunology* / Q000378:metabolism; D011379:Prognosis; D016212:Transforming Growth Factor beta / Q000378:metabolism
D000888:Antibodies, Anti-Idiotypic; D016207:Cytokines; D020381:Interleukin-17; D016209:Interleukin-8; D016212:Transforming Growth Factor beta
Autoimmunity; Cytokines; Myelofibrosis