A connectivity model for the locomotor network of Caenorhabditis elegans.
Recently, we described a new method for representing and analyzing the connectivity of a motoneuronal network. We used it to deduce a connectivity model for the neuromuscular network that generates locomotion in the nematode Caenorhabditis elegans. The network regulates muscle contraction and for this reason we used the location or function of body wall muscles to map every element (neuron or muscle cell) in a new framework, namely the peri-motor space. The previously published connectivity data for C. elegans locomotion network are incomplete; in particular, the connectivity of motoneurons in the posterior half of the animal is missing or partial. When we analyzed the connectivity data for motoneurons in the anterior half, we detected repeating patterns which we named iterativity. We analyzed the iterativity of each class of motoneuron and statistically validated that it is higher than expected by chance. We could then extrapolate the iteration into the posterior half. Here we will explain the new terms and elaborate on the process of analysis and the features of the new connectivity model.
Section on Developmental Neurobiology; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Bethesda, MD USA.
Gal
G
Haspel
Michael J
MJ
O'Donovan
Caenorhabditis elegans; locomotion; motoneurons; network connectivity; peri-motor