Rapid screening for detection and differentiation of detergent powder adulteration in infant milk formula by LC-MS.
Reports of infant milk formula adulteration by detergent powders as economic frauds and poisoning incidents are common as detergents are readily available and are inexpensive household items. Liquid chromatography (LC)-Qtrap and LC-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) in combination with chemometrics were effectively employed to detect the presence of detergent powder adulterated in infant milk formula. Partial least square analysis (PLS) regression was also utilized to quantify the amount of detergent powder in adulterated infant milk formula without the need to purchase any standards. Dodecylbenzenesulfonate (C12-LAS) was identified and verified as the marker which existed in detergent powder using LC-QTOF-MS. The amount of C12-LAS present in the admixture was successfully quantified through standard addition method.
Forensic Chemistry and Physics Laboratory, Health Sciences Authority, Republic of Singapore.
Manjun
M
Tay
Guihua
G
Fang
Poh Ling
PL
Chia
Sam Fong Yau
SF
Li
Adulteration; Detergent; Infant milk; LC–MS; Principal component analysis; Submit to Forensic Science International