Recent advances in heart regeneration.
Although cardiac stem cells (CSCs) and tissue engineering are very promising for cardiac regenerative medicine, studies with model organisms for heart regeneration will provide alternative therapeutic targets and opportunities. Here, we present a review on heart regeneration, with a particular focus on the most recent work in mouse and zebrafish. We attempt to summarize the recent progresses and bottlenecks of CSCs and tissue engineering for heart regeneration; and emphasize what we have learned from mouse and zebrafish regenerative models on discovering crucial genetic and epigenetic factors for stimulating heart regeneration; and speculate the potential application of these regenerative factors for heart failure. A brief perspective highlights several important and promising research directions in this exciting field.
are from Institute of Molecular Medicine, Peking University, Beijing, 100871, China and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100871, China.
Jing-Wei
JW
Xiong
Nan-Nan
NN
Chang
D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000637:transplantation; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D013234:Stem Cells; D023822:Tissue Engineering / Q000379:methods; D015027:Zebrafish
cardiac progenitors; cardiac tissue engineering; heart regeneration; mouse; zebrafish