Category-specific integration of homeostatic signals in caudal but not rostral human insula.
Prevailing theories hold that the insula is functionally organized along its caudal-to-rostral axis, with posterior regions coding lower-level sensory information and anterior regions coding higher-level stimulus significance relative to the body's homeostatic needs. Contrary to predictions of this model, the response of the taste-sensitive region of the caudal, but not rostral, insula to food images was directly related to the body's homeostatic state as indexed by levels of peripheral glucose.
1] Laureate Institute for Brain Research, Tulsa, Oklahoma, USA. [2] Faculty of Community Medicine, The University of Tulsa, Tulsa, Oklahoma, USA. [3] Laboratory of Brain and Cognition, National Institute of Mental Health (NIHM), National Institutes of Health (NIH), Bethesda, Maryland, USA.
W Kyle
WK
Simmons
Kristina M
KM
Rapuano
Seth J
SJ
Kallman
John E
JE
Ingeholm
Bernard
B
Miller
Stephen J
SJ
Gotts
Jason A
JA
Avery
Kevin D
KD
Hall
Alex
A
Martin
D000328:Adult; D000344:Afferent Pathways / Q000098:blood supply / Q000502:physiology*; D001786:Blood Glucose / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen; D010775:Photic Stimulation; D013649:Taste / Q000502:physiology*; D055815:Young Adult
D001786:Blood Glucose; D010100:Oxygen