One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization.
An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China. wangxiaojian@imm.ac.cn.
Yulin
Y
Tian
Jianguo
J
Qi
Chenbin
C
Sun
Dali
D
Yin
Xiaojian
X
Wang
Qiong
Q
Xiao
D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D007546:Isoquinolines; D010165:Palladium