From stealing fire to cellular reprogramming: a scientific history leading to the 2012 Nobel Prize.
Cellular reprogramming was recently "crowned" with the award of the Nobel Prize to two of its groundbreaking researchers, Sir John Gurdon and Shinya Yamanaka. The recent link between reprogramming and stem cells makes this appear almost a new field of research, but its historical roots have actually spanned more than a century. Here, the Nobel Prize in Physiology or Medicine 2012 is placed in its historical context.
Department of Pediatrics, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA ; Division of Hematology/Oncology, Howard Hughes Medical Institute/Boston Children's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA ; Harvard Stem Cell Institute, Holyoke Center, Suite 727W, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA.
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D000818:Animals; D065150:Cellular Reprogramming; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009613:Nobel Prize; D057905:Stem Cell Research / Q000266:history*