Characterization of hepatitis C infection in tuberculosis patients in an urban city in the USA.
The impact of hepatitis C virus infection (HCI), the most common bloodborne virus infection in the USA, on outcome of active tuberculosis (TB) treatment is largely unknown. We aimed to describe characteristics of TB patients with hepatitis C virus infection (TB-HCI) in King County, Washington, including TB treatment duration and outcome. We reviewed 1510 records of patients treated for active TB at the Public Health - Seattle & King County Tuberculosis Control Program between 2000 and 2010, and identified 53 with HCI. Advanced age, being born in the USA, HIV infection, homelessness and injection drug use were independently associated with HCI in TB cases. Independent factors associated with increased treatment duration included HIV infection, excess alcohol use, extrapulmonary TB, and any drug-resistant TB disease. Our findings suggest that TB-HCI patients can be successfully treated for active TB without extending treatment duration.
Department of Pulmonary and Critical Care Medicine,University of Washington,WA,USA.
M
M
Campo
Department of Epidemiology,University of Washington,WA,USA.
A
A
Shrestha
Department of Epidemiology,University of Washington,WA,USA.
E
E
Oren
Department of Epidemiology,University of Washington,WA,USA.
H
H
Thiede
Department of Epidemiology,University of Washington,WA,USA.
J
J
Duchin
Department of Pulmonary and Critical Care Medicine,University of Washington,WA,USA.
M
M
Narita
Department of Pulmonary and Critical Care Medicine,University of Washington,WA,USA.
K
K
Crothers
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D060085:Coinfection / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D005260:Female; D006526:Hepatitis C / Q000453:epidemiology* / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D014861:Washington / Q000453:epidemiology
D000995:Antitubercular Agents