Increased aortic stiffness predicts contrast-induced nephropathy in patients with stable coronary artery disease undergoing percutaneous coronary intervention.
Increased aortic stiffness (AS) has been shown to be an independent risk factor for cardiovascular disease in renal failure and was also found to be associated with even mild renal insufficiency. We investigated the relationship between contrast-induced nephropathy (CIN) and AS parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Patients (n = 440) with stable coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) were included prospectively (mean age: 60.3 ± 10.3 years). The PWV and AIx were calculated using the single-point method. The PWV, age, diabetes, SYNTAX score, and contrast media dose were independent predictors for CIN (P < .05, for all). The cutoff value for PWV obtained by the receiver-operator characteristic curve analysis was 10.35 m/s for the prediction of CIN (95% confidence interval: 0.838-0.916, sensitivity: 82.1%, specificity: 77.9%, and P < .001). In conclusion, a greater AS pre-PCI may predict CIN development in patients with stable CAD.
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey ucarhakan2005@gmail.com.
Hakan
H
Uçar
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Mustafa
M
Gür
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Arafat
A
Yildirim
Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey.
Abdürrezzak
A
Börekçi
Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey.
Mehmet Yavuz
MY
Gözükara
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Taner
T
Seker
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Onur
O
Kaypakli
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Caner
C
Türkoğlu
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Betül
B
Özaltun
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Selehattin
S
Akyol
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Hazar
H
Harbalioğlu
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Durmuş Yildiray
DY
Sahin
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Zafer
Z
Elbasan
Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
Murat
M
Çayli
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012372:ROC Curve; D012307:Risk Factors; D016896:Treatment Outcome; D059289:Vascular Stiffness
D003287:Contrast Media
PCI; aortic stiffness; contrast-induced nephropathy; coronary; pulse wave velocity