Risk factors for symptomatic and asymptomatic chikungunya infection.
BACKGROUND
In 2008, a chikungunya epidemic occurred in Southern Thailand. In many epidemics, there is a sizable number of asymptomatic cases. It is uncertain whether symptomatic and asymptomatic cases share the same risk factors.


METHODS
Residents aged 18 years or more from three villages were sampled, their venous blood tested for anti-chikungunya virus IgG (haemagglutination-inhibition [HI] technique), and a face-to-face interview conducted during a home visit.


RESULTS
Of 507 subjects selected, 314 (61.9%) were seropositive (HI titre≥1:10), of whom 148 (47.1%) were asymptomatic. Among subjects who reported fever and joint pain during the epidemic, 166 (97.1%) still had a positive titre. Having a garbage pile nearby and spending at least eight hours per day outdoors were associated with an increased risk of both symptomatic and asymptomatic chikungunya infection. Protective factors for symptomatic infection were age more than 58 and having a high level of formal education.


CONCLUSIONS
Transmission was determined by environmental conditions whereas symptoms were associated with personal biological factors and social setting.
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Phatchani
P
Nakkhara
Virasakdi
V
Chongsuvivatwong
Suwich
S
Thammapalo
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000453:epidemiology / Q000821:virology; D058345:Asymptomatic Infections / Q000453:epidemiology; D065632:Chikungunya Fever / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D002646:Chikungunya virus / Q000276:immunology*; D004522:Educational Status; D004781:Environmental Exposure; D005260:Female; D005735:Garbage; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult
D007074:Immunoglobulin G
Asymptomatic; Chikungunya; Risk factor; Symptomatic