Deep brain stimulation in dementia-related disorders.
Memory loss is the key symptom of dementia-related disorders, including the prevalent Alzheimer's disease (AD). To date, pharmacological treatments for AD have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to treat memory impairment and to reduce or stop the progression of it. Clinical and preclinical studies have been performed and stimulations of the fornix, entorhinal cortex and nucleus basalis of Meynert have been carried out. The results of these studies suggest that DBS has the potential to enhance memory functions in patients and animal models. The mechanisms underlying memory enhancement may include the release of specific neurotransmitters and neuroplasticity. Some authors suggest that DBS might even be disease-modifying. Nevertheless, it is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing clinical trials.
Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), Maastricht, The Netherlands. Electronic address: sarah.hescham@maastrichtuniversity.nl.
Sarah
S
Hescham
Lee Wei
LW
Lim
Ali
A
Jahanshahi
Arjan
A
Blokland
Yasin
Y
Temel
D000818:Animals; D046690:Deep Brain Stimulation; D003704:Dementia / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans
Alzheimer's disease; Deep brain stimulation; Dementia; Entorhinal cortex; Fornix; Hippocampus; Limbic system; Memory; Neuroanatomy; Nucleus basalis of Meynert; Papez circuit