[Changes of serum neuron-specific enolase and serum ferritin levels in patients with pneumoconiosis].
OBJECTIVE
To investigate the changes in serum neuron-specific enolase (NSE) and serum ferritin (SF) in patients with pneumoconiosis and their relationship with the onset of pneumoconiosis.


METHODS
The serum NSE and SF levels in the peripheral blood of patients with pneumoconiosis were measured by electrochemical fluorescence immunoassay.


RESULTS
The patients with first-stage pneumoconiosis and second-stage pneumoconiosis had significantly higher serum NSE and SF levels than the control group (23.0264±14.0410 and 44.9776±26.5208 ng/ml vs 8.1480±3.7512 ng/ml, P < 0.05; 267.2515±186.5809 and 579.1371±433.9326 ng/ml vs 120.8613±74.2809 ng/ml, P < 0.05), and the patients with second-stage pneumoconiosis had significantly higher serum NSE and SF levels than those with first-stage pneumoconiosis (P < 0.05). After treatment, the serum NSE level decreased significantly in the patients with pneumoconiosis (21.1675±17.5942 ng/ml vs 33.4490±21.6948 ng/ml, P < 0.05), but it was still significantly higher than that in the control group (P < 0.05). The treatment did not produce significant changes in SF level among these patients (P > 0.05).


CONCLUSIONS
Patients with pneumoconiosis have elevated serum NSE and SF levels, which may be related to the onset and progression of this disease.
Weifang People's Hospital, Weifang, Shandong Province 261041, China.
Feng-jie
FJ
Jiang
Shun-ji
SJ
Gao
Jun
J
Meng
Gui-fang
GF
Li
Xiao-juan
XJ
Sun
D000328:Adult; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011009:Pneumoconiosis / Q000097:blood*; D055815:Young Adult
D005293:Ferritins; D010751:Phosphopyruvate Hydratase