[Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo ].
Recent understandings of phosphate regulation have, at least in part, depended upon the findings of fibroblast growth factor (FGF) 23, the hormone specific for phosphate regulation. Moreover, FGF23 would be the most important marker for prognosis in chronic kidney disease (CKD) . On the other hand, Klotho was firstly developed as a responsible gene for senescence. Although the role of Klotho has been so far established as a co-receptor for FGF23 in mineral metabolism, Klotho would play rather various roles than FGF23 signaling. Thus Klotho is not necessarily equivalent to FGF23. Further studies for both Klotho and FGF23 will elucidate to understand mineral homeostasis.
Foundation for Biomedical Research and Innovation, Japan.
Akihiro
A
Imura
D000818:Animals; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D005966:Glucuronidase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D000090265:Klotho Proteins; D011485:Protein Binding; D051436:Renal Insufficiency, Chronic / Q000378:metabolism; D012279:Rickets / Q000235:genetics / Q000378:metabolism*
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins