Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk.
OBJECTIVE
To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population.


METHODS
Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested.


RESULTS
Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15-2.46) to 1.79 (95% CI: 1.16-2.75).


CONCLUSIONS
This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.
Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea; Research Institute for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea.
Hae Jong
HJ
Kim
Kyeoung-Hwa
KH
Kim
Jaehyouk
J
Lee
Jong Jin
JJ
Oh
Hyun Sub
HS
Cheong
Ee Lin
EL
Wong
Beom-Seok
BS
Yang
Seok Soo
SS
Byun
Soon Chul
SC
Myung
D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D056910:Republic of Korea
C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
FGF23; polymorphism; prostate cancer