EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.
The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic stem cell populations. The EGFR-Ras-Raf pathway has a well-described role in skin development and tumor formation. While research mainly focuses on its role in cutaneous tumor initiation and maintenance, much less is known about Ras signaling in the epidermal stem cells, which are the main targets of skin carcinogenesis. In this review, we briefly discuss the properties of the epidermal stem cells and review the role of EGFR-Ras-Raf signaling in keratinocyte stem cells during homeostatic and pathological conditions.
Max. F. Perutz Laboratories, Department of Microbiology, Immunology and Genetics, University of Vienna, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria. manuela.baccarini@univie.ac.at.
Eszter
E
Doma
Christian
C
Rupp
Manuela
M
Baccarini
D000818:Animals; D004817:Epidermis / Q000378:metabolism / Q000502:physiology*; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D018859:Hair Follicle / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*; D048490:raf Kinases / Q000235:genetics* / Q000378:metabolism; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism
D066246:ErbB Receptors; D048490:raf Kinases; D018631:ras Proteins