A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones.
Department of Chemistry, UCL, 20 Gordon St, London WC1H 0AJ, UK.
Lourdes
L
Castañeda
Zoë V F
ZV
Wright
Cristina
C
Marculescu
Trang M
TM
Tran
Vijay
V
Chudasama
Antoine
A
Maruani
Elizabeth A
EA
Hull
João P M
JP
Nunes
Richard J
RJ
Fitzmaurice
Mark E B
ME
Smith
Lyn H
LH
Jones
Stephen
S
Caddick
James R
JR
Baker
Bromomaleimides; Pyridazinediones; Reagent synthesis; Reagents for cysteine modification; Thiomaleimides