Pruritic acquired nevus of Ota.
Nevus of Ota is a unilateral, asymptomatic cutaneous and mucosal hyperpigmentation of the face that is congenital or may appear during childhood. We present a case of symptomatic acquired nevus of Ota in an adult, associated with intense pruritus, not described in the literature so far. A 32-year-old woman presented with brownish mottled macules which appeared on her face progressively over 8 days, following the distribution of the first and second divisions of the left trigeminal nerve and partially covering the iris and sclera of the left eye. She reported an intense pruritus in this area. We performed a biopsy on the left forehead, which confirmed the diagnosis of nevus of Ota. Specific stains and immunohistochemistry revealed increased numbers of mast cells. Ophthalmological tests showed acute acquired melanocytosis of the left iris and sclera. The origin of the nevus is still unclear. Several hypotheses suggest a reactivation of melanocytes during their migration from the neural crest. The pruritus reported in our patient may be explained by the increased quantity of mast cells observed in the lesion and/or neuronal stimulation of the ophthalmic and maxillary divisions of the fifth cranial nerve.
Department of Dermatology, Geneva University Hospitals, Geneva, Switzerland.
S
S
Quenan
V
V
Strueven
N
N
Saxer
E
E
Laffitte
G
G
Kaya
J
J
Krischer
F
F
Hafezi
F-A
FA
Le Gal
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005145:Face; D005260:Female; D006801:Humans; D009507:Nevus of Ota / Q000150:complications / Q000175:diagnosis*; D011537:Pruritus / Q000175:diagnosis / Q000209:etiology*; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis*