Krüppel-like factors in cancer.
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.
Department of Medicine, Gastroenterology Division, University of Pennsylvania Perelman School of Medicine, 913 Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia PA 19104-6144, USA.
Marie-Pier
MP
Tetreault
Yizeng
Y
Yang
Jonathan P
JP
Katz
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism; D009857:Oncogenes; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000235:genetics*; D059016:Tumor Microenvironment; D016335:Zinc Fingers
D051741:Kruppel-Like Transcription Factors; D009363:Neoplasm Proteins