Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors.
Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers.
Department of Pathology; University of Chicago; Chicago, IL USA.
Sven
S
Malchow
Daniel S
DS
Leventhal
Peter A
PA
Savage
AIRE; FOXP3; cancer; development; induced regulatory T cells; thymus; tumor