Magnetic resonance imaging of cardiovascular fibrosis and inflammation: from clinical practice to animal studies and back.
Late gadolinium enhancement is the technique of choice for detecting myocardial fibrosis. Although this technique is used in a wide range of cardiovascular pathologies, ischemic cardiomyopathy and the workup for myocarditis and other cardiomyopathies make up a significant proportion of the total indications. Multiple studies during the last decade have demonstrated its utility to adequately characterize myocardial tissue and offer diagnostic and prognostic information. Recent T1 mapping techniques aim to overcome the limitations of late gadolinium enhancement to assess diffuse fibrosis. ¹⁹F magnetic resonance has recently emerged as a promising technique for the assessment of inflammation. In the following review we will discuss the basic aspects of fibrosis assessment with MR and its utility for diagnostic and prognostic evaluation. We will also address the topic of cardiovascular inflammation imaging with ¹⁹F as a potential new development that may broaden the indications for MR in the future.
Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Adelina
A
Doltra
Philipp
P
Stawowy
Thore
T
Dietrich
Christopher
C
Schneeweis
Eckart
E
Fleck
Sebastian
S
Kelle
D000818:Animals; D004195:Disease Models, Animal; D004719:Endomyocardial Fibrosis / Q000175:diagnosis* / Q000473:pathology; D005682:Gadolinium; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D010818:Practice Patterns, Physicians'
D005682:Gadolinium