Association between interferon gamma +874 T>A polymorphism and acute renal allograft rejection: evidence from published studies.
Interferon gamma is involved in the acute rejection (AR) episodes of transplant recipients. However, results from published studies on the association of interferon gamma (IFNG) +874 T>A (rs2430561) polymorphism with AR of renal allograft are conflicting. To investigate the association between IFNG +874 T>A polymorphism with AR after renal transplantation, relevant studies were selected from PUBMED, EMBASE, Wanfang database and China National Knowledge Infrastructure until March 1st 2013. According the predesigned selection criteria, a total of 525 AR cases and 1,126 non-AR cases from 13 case-control studies were included to identify the strength of association with odds ratio (OR) and 95 % confidence intervals (95 % CI). Overall, a significant correlation between IFNG +874 T>A polymorphism and susceptibility to AR was detected (T allele vs. A allele: OR = 1.19, 95 % CI 1.02-1.38; TT/AT vs. AA: OR = 1.36, 95 % CI 1.07-1.73; TT vs. AA: OR = 1.42, 95 % CI 1.05-1.93; AT vs. AA: OR = 1.30, 95 % CI 1.01-1.68). In addition, ethnicity subgroup analysis revealed that high produce genotype (TT/AT) was associated with an increased risk of AR for Caucasians (TT/AT vs. AA: OR = 1.56, 95 % CI 1.14-2.12; TT vs. AA: OR = 1.64, 95 % CI 1.18-2.26). Furthermore, donor source subgroup analysis observed an increased risk for patients undergoing cadaveric kidney transplantation (TT/AT vs. AA: OR = 1.90, 95 % CI 1.12-3.24; TA vs. AA: OR = 2.16, 95 % CI 1.24-3.74). In conclusion, this meta-analysis suggested that IFNG +874 T>A polymorphism was associated with AR of renal transplant recipients, especially among Caucasians and those receiving cadaveric renal allograft. Additional well-designed studies with large sample size are warranted to validate our conclusion.
Department of Urology & Center of Renal Transplantation, Nanjing Hospital Affiliated to Nanjing Medical University, 68 Changle Road, Nanjing, 210006, China.
Yu-Zheng
YZ
Ge
Ran
R
Wu
Rui-Peng
RP
Jia
Hao
H
Liu
Peng
P
Yu
Yan
Y
Zhao
Yu-Ming
YM
Feng
D064591:Allografts / Q000473:pathology*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016030:Kidney Transplantation; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
C573415:IFNG protein, human; D007371:Interferon-gamma