Association of Lumican gene polymorphism with high myopia: a meta-analysis.
OBJECTIVE
Numerous studies have evaluated the association between the single-nucleotide polymorphism (SNP) (rs3759223, C→T) in Lumican gene and high myopia risk in the Chinese population. However, the results have been inconsistent. We therefore here examined whether the rs3759223 polymorphism confers high myopia risk by conducting a meta-analysis.


METHODS
PubMed, EMBASE, Science Citation Index, and Chinese National Knowledge Infrastructure (up to November 30, 2012) were searched by two investigators independently. Pooled relative ratios (RRs) and 95% confidence interval (CI) were used to assess the strength of the associations between SNP rs3759223 and myopia. Statistical analysis was undertaken using the program STATA 11.0 software (Stata Corporation, College Station, TX).


RESULTS
Five case-control studies involving 923 patients with high myopia and 622 controls were included in this meta-analysis. A significant relationship between SNP rs3759223 and high myopia in the Chinese population was found under the homozygote (RR = 1.47, 95% CI 1.01-2.12, p = 0.04) and recessive (RR = 1.69, 95% CI 1.09-2.62, p = 0.02) genetic models. However, no significant association was found under the heterozygote (RR = 1.01, 95% CI 0.76-1.35, p = 0.93) and dominant (RR = 1.06, 95%CI 0.90-1.26, p = 0.48) genetic models.


CONCLUSIONS
This meta-analysis showed the evidence that SNP rs3759223 may affect individual susceptibility to high myopia in the Chinese population. Given the limited sample size, further investigations are needed to validate the association.
*PhD †MD Department of Ophthalmology (Y-fF, YZ, Y-qC), the Affiliated Second Hospital of Wenzhou Medical College, Zhejiang, Republic of China; Department of Ophthalmology (Y-fF), Zhongshan Hospital, Fudan University, Shanghai, Republic of China; School of Medical Technology and Nursing (Y-lZ), Shenzhen Polytechnic College, Shenzhen, Guangdong, Republic of China; and The Affiliated Eye Hospital of Wenzhou Medical College (Y-hH), Zhejiang, Republic of China.
Yi-fan
YF
Feng
Yan-ling
YL
Zhang
Yi
Y
Zha
Jin-hai
JH
Huang
Jian-qiu
JQ
Cai
D044466:Asian People / Q000235:genetics; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007632:Keratan Sulfate / Q000235:genetics*; D000071234:Lumican; D009216:Myopia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D011508:Chondroitin Sulfate Proteoglycans; C000604306:LUM protein, human; D000071234:Lumican; D007632:Keratan Sulfate