Synthesis and biological evaluation of acyclic phosphonic acid nucleoside derivatives.
As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.
a Peakdale Molecular Ltd. , Chapel-en-le-Frith , Derbyshire , United Kingdom.
Philip
P
Wainwright
Adrian
A
Maddaford
Xiurong
X
Zhang
Helen
H
Billington
David
D
Leese
Rebecca
R
Glen
David C
DC
Pryde
Donald S
DS
Middleton
Peter T
PT
Stephenson
Scott
S
Sutton
D000144:Acids, Acyclic / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003715:Dengue / Q000188:drug therapy; D003716:Dengue Virus / Q000187:drug effects; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy; D016174:Hepacivirus / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D010757:Phosphorous Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation
D000144:Acids, Acyclic; D000998:Antiviral Agents; D009705:Nucleosides; D010757:Phosphorous Acids; C570063:phosphonic acid