Assessment of Parkinson's disease risk loci in Greece.
Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous risk variants pointing to novel pathways potentially implicated in the pathogenesis of PD. Contributing to these GWAS efforts, we performed genotyping of previously identified risk alleles in PD patients and control subjects from Greece. We showed that previously published risk profiles for Northern European and American populations are also applicable to the Greek population. In addition, although our study was largely underpowered to detect individual associations, we replicated 5 of 32 previously published risk variants with nominal p values <0.05. Genome-wide complex trait analysis revealed that known risk loci explain disease risk in 1.27% of Greek PD patients. Collectively, these results indicate that there is likely a substantial genetic component to PD in Greece, similarly to other worldwide populations, that remains to be discovered.
Reta Lila Weston Laboratories and Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
Eleanna
E
Kara
Georgia
G
Xiromerisiou
Cleanthe
C
Spanaki
Maria
M
Bozi
Georgios
G
Koutsis
Marios
M
Panas
Efthimios
E
Dardiotis
Styliani
S
Ralli
Jose
J
Bras
Christopher
C
Letson
Connor
C
Edsall
Hannah
H
Pliner
Sampath
S
Arepalli
Kallirhoe
K
Kalinderi
Liana
L
Fidani
Sevasti
S
Bostantjopoulou
Margaux F
MF
Keller
Nicholas W
NW
Wood
John
J
Hardy
Henry
H
Houlden
Leonidas
L
Stefanis
Andreas
A
Plaitakis
Dena
D
Hernandez
Georgios M
GM
Hadjigeorgiou
Mike A
MA
Nalls
Andrew B
AB
Singleton
D000368:Aged; D000483:Alleles; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D012306:Risk
GCTA; GWAS; Genetics; Greece; Parkinson's disease; Risk profiles