Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children.
Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.
Malawi-Liverpool-Wellcome Clinical Research Programme.
Christopher A
CA
Moxon
Ngawina V
NV
Chisala
Samuel C
SC
Wassmer
Terrie E
TE
Taylor
Karl B
KB
Seydel
Malcolm E
ME
Molyneux
Brian
B
Faragher
Neil
N
Kennedy
Cheng-Hock
CH
Toh
Alister G
AG
Craig
Robert S
RS
Heyderman
D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002675:Child, Preschool; D004727:Endothelium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005334:Fever / Q000097:blood / Q000469:parasitology / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000469:parasitology / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016779:Malaria, Cerebral / Q000097:blood / Q000473:pathology*; D016778:Malaria, Falciparum / Q000097:blood / Q000473:pathology*; D008295:Malawi; D008297:Male; D033921:Vesicular Transport Proteins / Q000097:blood
D015415:Biomarkers; C555023:VPS51 protein, human; D033921:Vesicular Transport Proteins; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein
Plasmodium falciparum; cardiovascular disease; endothelial activation; endothelial dysfunction; inflammation; pathogen burden; pediatric; stroke