Hepatitis C: a mouse at the end of the tunnel.
Since its discovery in 1989, researchers strive after a small animal model for Hepatitis C virus infection, so far with very limited success. A study recently published in Nature now for the first time reports the recapitulation of the complete life cycle of this virus in inbred mice with a functional adaptive immune system.
Department of Infectious Diseases, Molecular Virology, University of Heidelberg, INF 345, D-69120 Heidelberg, Germany.
Marco
M
Binder
Ralf
R
Bartenschlager
D000818:Animals; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D053586:Virus Internalization
D008565:Membrane Proteins