Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols.
A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts allylation/intramolecular hydroalkoxylation sequence. The reaction is mild, practical and tolerant of a wide variety of substituents on the phenol.
Institute of Chemical Sciences, Heriot-Watt University, Edinburgh, EH14 1LP, United Kingdom.
Eloi
E
Coutant
Paul C
PC
Young
Graeme
G
Barker
Ai-Lan
AL
Lee
Friedel–Crafts; allylic alcohols; chromans; gold catalysis; heterocycles