IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape.
The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.
Cutaneous Medicine and Immunotherapy Unit; St. John's Institute of Dermatology; Division of Genetics and Molecular Medicine & NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London; London, UK.
Panagiotis
P
Karagiannis
Amy E
AE
Gilbert
Frank O
FO
Nestle
Sophia N
SN
Karagiannis
B cells; FcγRI; IL-10; IgG4; VEGF; antibody effector functions; cancer inflammation; immune escape; melanoma