Modeling the allosteric modulation of CCR5 function by Maraviroc.
Maraviroc is a non-peptidic, low molecular weight CC chemokine receptor 5 (CCR5) ligand that has recently been marketed for the treatment of HIV infected individuals. This review discusses recent molecular modeling studies of CCR5 by homology to CXC chemokine receptor 4, their contribution to the understanding of the allosteric mode of action of the inhibitor and their potential for the development of future drugs with improved efficiency and preservation of CCR5 biological functions.
Bernard
B
Lagane
Javier
J
Garcia-Perez
Esther
E
Kellenberger
D000494:Allosteric Regulation; D000818:Animals; D003510:Cyclohexanes / Q000494:pharmacology*; D023581:HIV Fusion Inhibitors / Q000494:pharmacology*; D006801:Humans; D000077592:Maraviroc; D008958:Models, Molecular; D011487:Protein Conformation; D019713:Receptors, CCR5 / Q000737:chemistry / Q000378:metabolism*; D014230:Triazoles / Q000494:pharmacology*
D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D019713:Receptors, CCR5; D014230:Triazoles; D000077592:Maraviroc