Synthesis and antibacterial evaluation of some novel imidazole and benzimidazole sulfonamides.
Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by ¹H-NMR, ¹³C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of six Gram positive and four Gram negative bacteria using the microbroth dilution assay. Most of the compounds studied showed promising activities against both types of bacteria.
Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. nassir@siswa.um.edu.my.
Nassir N
NN
Al-Mohammed
Yatimah
Y
Alias
Zanariah
Z
Abdullah
Raied M
RM
Shakir
Ekhlass M
EM
Taha
Aidil Abdul
AA
Hamid
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D017550:Spectroscopy, Fourier Transform Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D001562:Benzimidazoles; D007093:Imidazoles; D013449:Sulfonamides