[Prolongation of QT interval and evaluation of safety of drugs].
People pay more and more attention to the prolongation of QT interval caused by drugs because it could probably result in lethal arrhythmia. This article introduces mechanisms, risk factors and guidelines for QT interval, and also reviews drugs withdrawal from the market due to the results of prolongations of QT interval. It discusses as well the value of new drugs in the QT interval for the evaluation of safety.
Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Yan
Y
Li
Jing
J
Xu
Wensheng
W
Zhang
D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000209:etiology; D008297:Male; D012307:Risk Factors