Tissue competence imprinting and tissue residency of CD8 T cells.
T cell immunity is characterized by striking tissue specialization. Tissue-specificity imprinting starts during priming by tissue-derived migratory dendritic cells in the non-random, specialized micro-anatomical area of the draining lymph node and is influenced by constitutive and induced cues from local environment. Besides tissue-specific effectors, memory cells also exhibit a tissue-specificity. Long-lived tissue-resident memory T cells likely play a considerable role in preventing pathogen invasion. Understanding of the mechanisms of tissue specialization of T cells is of major importance for the design of optimal vaccination strategies and therapeutic interventions in tissue/organ-specific inflammatory diseases. The present review summarizes our current knowledge and hypothesis about tissue-specificity imprinting and tissue residency of T cells.
Department of Immunology, CHU Bicêtre , Le Kremlin-Bicêtre , France ; INSERM U-996 , Clamart , France.
Roman
R
Krzysiek
Marie-Ghislaine
MG
de Goër de Herve
Heng
H
Yang
Yassine
Y
Taoufik
effector T cells; memory T cells; tissue residency; tissue-specific imprinting