Single-base DNA discrimination via transverse ionic transport.
We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.
Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
James
J
Wilson
M
M
Di Ventra
D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000737:chemistry* / Q000378:metabolism*; D017136:Ion Transport; D007477:Ions / Q000378:metabolism*; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation
D004277:DNA, Single-Stranded; D007477:Ions