Progressive kidney failure as the sole manifestation of extrapulmonary sarcoidosis.
Sarcoidosis is a chronic multisystem disorder characterized by an accumulation of T lymphocytes and mononuclear phagocytes, non-caseating epitheliod granulomas and derangement of normal tissue architecture in affected organs. Sarcoidosis can affect any organ system, however approximately 90% of patients with sarcoidosis have pulmonary, lymph node, cutaneous or ocular manifestations. Renal involvement in sarcoidosis is rare and clinically significant renal dysfunction even less common. We present a case of isolated renal sarcoidosis which manifested with progressively worsening renal function and hypercalcemia. A systematic diagnostic approach with pertinent laboratory studies, imaging and renal biopsy elucidated the diagnosis of renal sarcoidosis without any evidence of systemic involvement.
Division of Nephrology, University of Arkansas for Medical Sciences, USA.
Supreet
S
Sethi
Nitin
N
Relia
Gaurav
G
Syal
Chhavi
C
Kaushik
Neriman
N
Gokden
Ahmad B
AB
Malik
D000368:Aged; D018450:Disease Progression; D006099:Granuloma / Q000209:etiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology*; D008297:Male; D051437:Renal Insufficiency / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications* / Q000276:immunology / Q000473:pathology*