[Protective effect of yixinshu capsule on myocardial ischemia reperfusion injury in rats].
OBJECTIVE
To observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury (MIRI) in SD rats.


METHODS
Sixty healthy SD rats were randomized into six groups: sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined.


RESULTS
Yixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size.


CONCLUSIONS
Yixinshu capsule can protect against MIRI in rats.
Key Research Laboratory for Development of New Drugs, The Second Xiangya Hospital of Central South University, Changsha 410013, China. 4604430@qq.com
Jia-Wen
JW
Liu
Xin-Yi
XY
Liu
Jian-He
JH
Li
Da-Xiong
DX
Xiang
Li-Dan
LD
Yi
Xiong-Bin
XB
Hu
Zu-Guang
ZG
Ye
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D004365:Drugs, Chinese Herbal