Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study (MoBa).
Maternal diet not only provides essential nutrients to the developing fetus but is also a source of prenatal exposure to environmental contaminants. We investigated the association between dietary intake of dioxins and PCBs during pregnancy and birth size. The study included 50,651 women from the Norwegian Mother and Child Cohort Study (MoBa). Dietary information was collected by FFQs and intake estimates were calculated by combining food consumption and food concentration of dioxins, dioxin-like PCBs and non-dioxin-like PCBs. We used multivariable regression models to estimate the association between dietary intake of dioxins and PCBs and fetal growth. The contribution of fish and seafood intake during pregnancy was 41% for dietary dioxins and dioxin-like PCBs and 49% for dietary non-dioxin-like PCBs. Further stratified analysis by quartiles of seafood intake during pregnancy was conducted. We found an inverse dose-response association between dietary intake of dioxins and PCBs and fetal growth after adjustment for confounders. Newborns of mothers in the upper quartile of dioxin and dioxin-like PCBs intake had 62g lower birth weight (95% CI: -73, -50), 0.26cm shorter birth length (95% CI: -0.31, -0.20) and 0.10cm shorter head circumference (95% CI: -0.14, -0.06) than newborns of mothers in the lowest quartile of intake. Similar negative associations for intake of dioxins and dioxin-like PCBs were found after excluding women with intakes above the tolerable weekly intake (TWI=14pg TEQ/kg bw/week). The negative association of dietary dioxins and PCBs with fetal growth was weaker as seafood intake was increasing. No association was found between dietary dioxin and PCB intake and the risk for small-for-gestational age neonate. In conclusion, dietary intakes of dioxins and PCBs during pregnancy were negatively associated with fetal growth, even at intakes below the TWI.
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; Pompeu Fabra University, Barcelona, Spain. Electronic address: eleni.papadopoulou@fhi.no.
Eleni
E
Papadopoulou
Ida H
IH
Caspersen
Helen E
HE
Kvalem
Helle K
HK
Knutsen
Talita
T
Duarte-Salles
Jan
J
Alexander
Helle Margrete
HM
Meltzer
Manolis
M
Kogevinas
Anne Lise
AL
Brantsæter
Margaretha
M
Haugen
D000328:Adult; D000818:Animals; D001724:Birth Weight; D015331:Cohort Studies; D004147:Dioxins / Q000032:analysis*; D004435:Eating; D005260:Female; D047109:Fetal Development; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D009664:Norway / Q000453:epidemiology; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012044:Regression Analysis; D017747:Seafood / Q000032:analysis; D055815:Young Adult
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls
Birth weight; Diet; Dioxins; MoBa; PCB; Pregnancy