Extremes of lineage plasticity in the Drosophila brain.
An often-overlooked aspect of neural plasticity is the plasticity of neuronal composition, in which the numbers of neurons of particular classes are altered in response to environment and experience. The Drosophila brain features several well-characterized lineages in which a single neuroblast gives rise to multiple neuronal classes in a stereotyped sequence during development. We find that in the intrinsic mushroom body neuron lineage, the numbers for each class are highly plastic, depending on the timing of temporal fate transitions and the rate of neuroblast proliferation. For example, mushroom body neuroblast cycling can continue under starvation conditions, uncoupled from temporal fate transitions that depend on extrinsic cues reflecting organismal growth and development. In contrast, the proliferation rates of antennal lobe lineages are closely associated with organismal development, and their temporal fate changes appear to be cell cycle-dependent, such that the same numbers and types of uniglomerular projection neurons innervate the antennal lobe following various perturbations. We propose that this surprising difference in plasticity for these brain lineages is adaptive, given their respective roles as parallel processors versus discrete carriers of olfactory information.
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Suewei
S
Lin
Elizabeth C
EC
Marin
Ching-Po
CP
Yang
Chih-Fei
CF
Kao
Bettye A
BA
Apenteng
Yaling
Y
Huang
Michael B
MB
O'Connor
James W
JW
Truman
Tzumin
T
Lee
D000818:Animals; D057506:Arthropod Antennae / Q000166:cytology / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D007328:Insulin / Q000378:metabolism; D007814:Larva; D024521:Mushroom Bodies / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics; D009473:Neuronal Plasticity; D009833:Olfactory Pathways / Q000166:cytology / Q000378:metabolism*; D050809:POU Domain Factors / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D013217:Starvation; D014157:Transcription Factors / Q000235:genetics
D029721:Drosophila Proteins; C557617:GAL4 protein, Drosophila; D007328:Insulin; D009419:Nerve Tissue Proteins; D050809:POU Domain Factors; D014157:Transcription Factors; C068431:acj6 protein, Drosophila; D049452:Green Fluorescent Proteins; C094982:InR protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases