Production of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Malassezia pachydermatis G-14.
To produce a novel antihypertensive angiotensin I-converting enzyme (ACE) inhibitor from yeast, a yeast isolate, designated G-14 showing the highest ACE inhibitory activity was obtained and identified as Malassezia pachydermatis based on morphological, biochemical and cultural characteristics. The maximal extracellular ACE inhibitor production was obtained from M. pachydermatis G-14 when the strain was cultured in YEPD medium containing 0.5% yeast extract, 3.0% peptone and 2.0% glucose at 30℃ for 24 h and the final ACE inhibitory activity was 48.9% under the above condition.
Department of Genetic Engineering and Bio-medicinal Resource Research Center, Paichai University, Daejeon 302-735, Korea.
Seung Chan
SC
Jeong
Jae Ho
JH
Kim
Na-Mi
NM
Kim
Jong Soo
JS
Lee
Angiotensin I-converting enzyme inhibitor; Antihypertensive; Malassezia pachydermatis