Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases.
We investigated the pathological features of frontotemporal lobar degeneration (FTLD) with fused in sarcoma protein (FUS) accumulation (FTLD-FUS) in the Japanese population. Only one out of nine FTLD-FUS cases showed pathology that corresponds to atypical FTLD with ubiquitin-positive inclusions (aFTLD-U). Five were basophilic inclusion body disease (BIBD) and two were neuronal intermediate filament inclusion disease. The last case was unclassifiable and was associated with dystrophic neurites (DNs) as the predominant FUS pathology. The results of this study indicate an ethnic difference from western countries. In Japan, BIBD is the most common subtype of FTLD-FUS and aFTLD-U is rare, a finding which contrasts with aFTLD-U being the most common form in western countries. Immunohistochemical analyses of these FTLD-FUS cases reveal that FUS abnormally accumulated in neuronal cytoplasmic inclusions (NCIs) and DNs has an immunohistochemical profile distinct from that of normal, nuclear FUS. NCIs and DNs are more readily stained than the nuclei by antibodies to the middle portion of FUS. Antibodies to the carboxyl terminal portion, on the other hand, stain the nuclei more readily than NCIs and DNs. Such an immunohistochemical profile of NCIs and DNs was similar to that of cytoplasmic granular FUS staining which we previously reported to be associated with dendrites and synapses. Redistribution of FUS from the nucleus to the cytoplasm could be associated with the formation of abnormal FUS aggregates in FTLD-FUS.
Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Neurology, JA Toride Medical Center, Toride, Ibaraki, Japan.
Zen
Z
Kobayashi
Ito
I
Kawakami
Tetsuaki
T
Arai
Osamu
O
Yokota
Kuniaki
K
Tsuchiya
Hiromi
H
Kondo
Yoko
Y
Shimomura
Chie
C
Haga
Naoya
N
Aoki
Masato
M
Hasegawa
Masato
M
Hosokawa
Kenichi
K
Oshima
Kazuhiro
K
Niizato
Hideki
H
Ishizu
Seishi
S
Terada
Mitsumoto
M
Onaya
Manabu
M
Ikeda
Kiyomitsu
K
Oyanagi
Imaharu
I
Nakano
Shigeo
S
Murayama
Haruhiko
H
Akiyama
Hidehiro
H
Mizusawa
D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D034702:RNA-Binding Protein FUS / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
D034702:RNA-Binding Protein FUS; D025801:Ubiquitin
BIBD; Frontotemporal lobar degeneration; Fused in sarcoma; Immunohistochemistry; NIFID; aFTLD-U