Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the therapeutic delivery of the dequalinium salt of bis-nido-carborane.
Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the boron neutron capture therapy of cancer.
Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Technology, GR-54124 Thessaloniki, Greece.
Dimitrios
D
Theodoropoulos
Aikaterini
A
Rova
James R
JR
Smith
Eugen
E
Barbu
Gianpiero
G
Calabrese
Ioannis S
IS
Vizirianakis
John
J
Tsibouklis
Dimitrios G
DG
Fatouros
D016754:Boron Neutron Capture Therapy / Q000379:methods*; D003868:Dequalinium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000532:radiotherapy; D010713:Phosphatidylcholines / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D008081:Liposomes; D010713:Phosphatidylcholines; D003868:Dequalinium; C015712:bisdequalinium; D004134:Dimyristoylphosphatidylcholine
Bis-nido-carborane; Boron neutron capture therapy; Liposomes; Stability; Toxicity