Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy.
Psoriasis is an autoimmune, chronic, inflammatory skin disease characterized by epidermal hyperplasia, proliferation of blood vessels, and infiltration of leukocytes in dermis and epidermis. Several immunosuppressants such as methotrexate (MXT) and cyclosporine are used but they are associated with adverse effects due to down regulation of immune system. Numerous approaches have been explored to overcome the problems of conventional topical system such as high frequency of application, impermeability to skin barrier, and limited efficacy. Photodynamic therapy is another non-invasive technique currently used for skin diseases. The combination of two drugs is also commonly observed to achieve more effective therapy. In the present study, antipsoriatic activity of niosomal formulations for the treatment of psoriasis in combination with narrow and broad band UV radiation had been explored in experimental animal model.
Department of Pharmaceutics, ISF College of Pharmacy , Moga, Punjab , India.
Nupur
N
Parnami
Tarun
T
Garg
Goutam
G
Rath
Amit K
AK
Goyal
D000287:Administration, Topical; D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage*; D008727:Methotrexate / Q000008:administration & dosage; D008815:Mice, Inbred Strains; D054118:Nanospheres / Q000008:administration & dosage*; D054158:Orthokeratologic Procedures; D010241:Parakeratosis / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D014307:Trioxsalen / Q000008:administration & dosage; D014467:Ultraviolet Therapy
D008081:Liposomes; D014307:Trioxsalen; D008727:Methotrexate
immunosuppressant; orthokeratosis; photodynamic therapy; psoriasis