Another review on triple negative breast cancer. Are we on the right way towards the exit from the labyrinth?
Triple negative breast cancer is a heterogeneous group of tumors, lacking the expression of estrogen, progesterone and HER-2 receptors. As frequency, it accounts about 15-20% of all breast cancers. Although in the last years there was a "boom" in publishing over this issue, multiple molecular classifications being elaborated, "the triple negative breast cancer odyssey " is still far away from ending, as the complicated molecular pathways of pathogenesis and drug resistance mechanisms remain yet insufficiently explored. The aim of this review is presentation of molecular signatures that could predict outcome and drug resistance in triple negative breast cancer.
Clinical University Hospital of Dermatovenereology, Cluj-Napoca, Romania; Department of Dermatology, University of Freiburg, Freiburg, Germany; Department of Functional Genomics and Experimental Pathology, The Oncological Institute - Prof. Dr. Ion Chiricuta, Cluj-Napoca, Romania.
Roxana
R
Chiorean
Cornelia
C
Braicu
Ioana
I
Berindan-Neagoe
D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015870:Gene Expression; D006801:Humans; D064726:Triple Negative Breast Neoplasms / Q000145:classification / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor
Molecular markers; Outcome; Resistance to chemotherapy; Triple negative breast cancer