Novel perspectives on dendritic cell-based immunotherapy of cancer.
Advances in immunobiology knowledge as well as in cell culture processes that generate large numbers of purified and functionally mature dendritic cells (DCs) have raised the possibility that DCs might represent promising clinical agents to generate effective immune responses against cancer. Here, we discuss the present pitfalls of dendritic cell vaccines for the treatment of human cancer with regard to the most recent knowledge in the biology of DCs. In particular, we highlight the relevance of improving our current understanding of DC trafficking, functions and interactions with other cells of innate immunity for the development of more effective cancer vaccines.
Laboratory of Immunology and Biotherapy, Department Human Pathology, University of Messina, Italy; Cellular Therapy Program, University Hospital - A.O.U. Policlinico, Messina, Italy.
Irene
I
Bonaccorsi
Gaetana
G
Pezzino
Barbara
B
Morandi
Guido
G
Ferlazzo
D000818:Animals; D019496:Cancer Vaccines; D002450:Cell Communication; D018929:Cell Culture Techniques; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D006801:Humans; D007113:Immunity, Innate; D016219:Immunotherapy, Adoptive / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
D019496:Cancer Vaccines
Cancer vaccines; Cell interactions; Dendritic cells; Immunotherapy; Lymph