Direct access to highly substituted 1-naphthols through palladium-catalyzed oxidative annulation of benzoylacetates and internal alkynes.
One for the pot: 1-Naphthols, well-known structural design elements in medicinal chemistry, were readily prepared by means of a one-pot palladium-catalyzed oxidative annulation of readily available benzoylacetates to internal alkynes.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (+65) 6516-1691.
Shiyong
S
Peng
Lei
L
Wang
Jian
J
Wang
D000480:Alkynes / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry
D000480:Alkynes; D001565:Benzoates; D009284:Naphthols; C029350:1-naphthol; D010165:Palladium
CH activation; alkynes; annulation; naphthols; palladium