Impact of reduced-intensity conditioning allogeneic stem cell transplantation on women's fertility.
BACKGROUND
Available data on women fertility for younger patients treated using RIC Allo-SCT are still limited. We evaluated ovarian function and fertility among female patients younger than 35 years who received RIC Allo-SCT for hematological malignancy or aplastic anemia (AA).


METHODS
Information on therapies before RIC Allo-SCT were collected. Data on ovarian function and fertility evaluation after RIC Allo-SCT included clinical and biological criteria. Twenty-two patients were evaluated.


RESULTS
After RIC Allo-SCT, amenorrhea affects 68.1% of patients. Ovarian function was impaired for 86.3% of cases. All 3 AA patients have regular cycles and became pregnant after RIC Allo-SCT. Only 6 (27.2%) patients declared to have been correctly informed before RIC Allo-SCT on potential deleterious effects on fertility of anticancer treatment and only 36.8% of patients with ovarian failure had a hormonal supplementation.


CONCLUSIONS
Results showed a high rate of ovarian failure, evaluated by clinical and biological criteria. The difference between AA and malignant diseases might suggest that a potential deleterious role was played by previous anticancer treatments rather than by RIC Allo-SCT.
Department of Oncology, Institut Paoli-Calmettes, Marseille, France. Electronic address: assoulinee@ipc.unicancer.fr.
Emmanuelle
E
Assouline
Roberto
R
Crocchiolo
Thomas
T
Prebet
Florence
F
Broussais
Diane
D
Coso
Marc
M
Gamerre
Norbert
N
Vey
Didier
D
Blaise
Blandine
B
Courbiere
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000528:radiation effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000379:methods; D014184:Transplantation, Homologous; D055815:Young Adult
Allogeneic stem cell transplantation; Chemotherapy; Fertility preservation; Hormone replacement therapy; Premature ovarian failure