Natural clovanes from the gorgonian coral Rumphella antipathies.
Three natural clovane-related sesquiterpenoids, 2beta-acetoxyclovan-9alpha-ol (1), 9alpha-acetoxyclovan-2beta-ol (2) and clovan-2beta,9beta-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Hsu-Ming
HM
Chung
Wei-Hsien
WH
Wang
Tsong-Long
TL
Hwang
Yang-Chang
YC
Wu
Ping-Jyun
PJ
Sung
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000737:chemistry / Q000378:metabolism; D010196:Pancreatic Elastase / Q000737:chemistry / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012717:Sesquiterpenes; D010196:Pancreatic Elastase