Circadian aspects of energy metabolism and aging.
Life span extension has been a goal of research for several decades. Resetting circadian rhythms leads to well being and increased life span, while clock disruption is associated with increased morbidity accelerated aging. Increased longevity and improved health can be achieved by different feeding regimens that reset circadian rhythms and may lead to better synchrony in metabolism and physiology. This review focuses on the circadian aspects of energy metabolism and their relationship with aging in mammals.
Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address: oren.froy@mail.huji.ac.il.
Oren
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Froy
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D056926:CLOCK Proteins / Q000096:biosynthesis / Q000235:genetics; D031204:Caloric Restriction / Q000379:methods; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
D056926:CLOCK Proteins
Aging; Circadian rhythms; Clock; Life span; Metabolism