[Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma].
OBJECTIVE
To examine the association of 5-lipoxygenase (5-LOX) expression with clinicopathological factors in colorectal cancer.


METHODS
Immunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer. The association between 5-LOX expression and clinicopathological factors was examined.


RESULTS
The positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1% (38/52). In 41 colorectal cancer specimens with lymph node metastasis, the positive rate of 5-LOX expression was higher than that in the specimens without metastasis (87.8% vs. 18.2%, P<0.05). The positive rate of 5-LOX expression in the specimens with deep infiltration (T3 and T4) was higher than that in the specimens with superficial infiltration (T1 and T2) (81.1% vs. 53.3%, P<0.05). The positive rate of 5-LOX expression in TNM stage III and IIII cancer was higher than that in stage I and II (79.5% vs. 53.8%, P<0.05). The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer (100% vs. 50.0%, P<0.05). There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.


CONCLUSIONS
5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis, infiltration depth, differentiation degree and TNM stage.
Department of Oncology Surgery, Dongguan People's Hospital, Guangdong Dongguan 523059, China. liyuechun@sina.com.
Yue-chun
YC
Li
Dong-xia
DX
Wang
Cai-shi
CS
Li
Zhen-peng
ZP
Ye
Zhi-ming
ZM
Wu
Jian-hua
JH
Chen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D001094:Arachidonate 5-Lipoxygenase