Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise.
The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised.
Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil; Programa de Pós Graduação em Ciências Biológicas: Fisiologia-Farmacologia, CAPES Foundation, Ministry of Education of Brazil, Brasília, DF 70040-020, Brazil.
Danielle
D
Bernardes
Onésia Cristina
OC
Oliveira-Lima
Thiago Vitarelli da
TV
Silva
Camila Cristina Fraga
CC
Faraco
Hércules Ribeiro
HR
Leite
Maria Aparecida
MA
Juliano
Daniel Moreira dos
DM
Santos
John R
JR
Bethea
Roberta
R
Brambilla
Jacqueline M
JM
Orian
Rosa Maria Esteves
RM
Arantes
Juliana
J
Carvalho-Tavares
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology* / Q000534:rehabilitation*; D004797:Enzyme-Linked Immunosorbent Assay; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D007958:Leukocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000633:toxicity; D010446:Peptide Fragments / Q000633:toxicity; D010805:Physical Conditioning, Animal / Q000379:methods; D013116:Spinal Cord / Q000378:metabolism*; D013550:Swimming; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55); D005620:Freund's Adjuvant
BDNF; Exercise; Experimental autoimmune encephalomyelitis; Intravital microscopy; Neuroinflammation; Neuroprotection