Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment.
Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N = 16) and PiB (+) (N = 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.
Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
Byoung Seok
BS
Ye
Sang Won
SW
Seo
Chi Hun
CH
Kim
Seun
S
Jeon
Geon Ha
GH
Kim
Young
Y
Noh
Hanna
H
Cho
Cindy W
CW
Yoon
Hee Jin
HJ
Kim
Eun Young
EY
Jang
Jeongmin
J
Lee
Jung-Hyun
JH
Kim
Juhee
J
Chin
Jong Min
JM
Lee
Jeong-Hun
JH
Kim
Joon-kyung
JK
Seong
Chang-Hun
CH
Kim
Yearn Seong
YS
Choe
Kyung Han
KH
Lee
Duk L
DL
Na
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D001284:Atrophy; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012306:Risk; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles
Alzheimer's disease; Cortical thickness; Hippocampus; Mild cognitive impairment; Pittsburgh compound B