Screening for a diamond in the rough.
Contrary to the standard of eliminating antimicrobial hits that collapse bacterial proton motive force (PMF), in this issue of Chemistry and Biology, Farha and colleagues describe the value of screens to identify molecules that dissipate PMF, yet are nonbacteriolytic and selectively toxic.
Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.
Xiaoqian
X
Wu
Julian G
JG
Hurdle
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D018892:Proton-Motive Force / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000378:metabolism*
D000900:Anti-Bacterial Agents