Balancing survival: the role of CTGF in controlling experience-modulated olfactory circuitry.
The subventricular zone (SVZ) continuously supplies new interneurons that incorporate into pre-existing olfactory bulb circuitry. Khodosevich et al. (2013) show that connective tissue growth factor (CTGF) regulates a multicellular signaling cascade determining the number of postnatally born inhibitory interneurons in odor-activated glomeruli.
Department of Neuroscience, Department of Molecular Biology and Genetics, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, MD 21205, USA.
Tanu
T
Sharma
Randall R
RR
Reed
D000818:Animals; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D008297:Male; D009830:Olfactory Bulb / Q000166:cytology*; D012903:Smell / Q000235:genetics*
D055513:Connective Tissue Growth Factor