[Expression of serum cytokines in patients with pneumoconiosis by antibody chip].
OBJECTIVE
To investigate the changes in expression of serum cytokines in patients with pneumoconiosis using cytokine antibody chips (CACs).


METHODS
The CAC technology was applied to measure the serum levels of 60 cytokines in 12 patients with pneumoconiosis and 3 normal controls.


RESULTS
In the patients with pneumoconiosis, the highly expressed serum cytokines included interleukin (IL)-1α, IL-1β, IL-2, ILs 4-16, macrophage colony-stimulating factor, interferon-γ, tumor necrosis factor (TNF)-α, TNF-β, human bone morphogenetic protein-6, fibroblast growth factor-7, neurotrophin-3, and stem cell factor, and the lowly expressed serum cytokines included recombinant human I-309, monocyte chemoattractant protein (MCP)-1, MCP-2, MCP-3, MCP-4, macrophage inflammatory protein (MIP)-1-δ, and MIP-3-α.


CONCLUSIONS
Patients with pneumoconiosis have changes in the expression of most serum cytokines.
Department of Occupational Disease and Clinical Toxicology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Yu-jing
YJ
Xia
Feng-tong
FT
Hao
Li-ming
LM
Xu
Chang-jiang
CJ
Xue
Ying-mei
YM
Niu
D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000097:blood*
D016207:Cytokines