Eco-efficient ultrasonic responsive synthesis of pyrimidines/pyridines.
Using ultrasound irradiation, two simple one-pot multicomponent methods are described for syntheses of highly functionalized pyrimidine/pyridine derivatives in excellent yields in the presence of NaOH at room temperature. While one route involved aromatic aldehyde, thiourea and acetoacetanilide, the other employed aromatic aldehyde, malononitrile and benzyl mercaptane or EtOH. These approaches afford several advantages over former and contemporary reaction methodologies in terms of operational simplicity, simple work-up procedure, higher yield, short reaction time and environment friendly protocols.
School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa.
Ramakanth
R
Pagadala
Suresh
S
Maddila
Sreekantha B
SB
Jonnalagadda
D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D055772:Green Chemistry Technology / Q000379:methods*; D011725:Pyridines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D012972:Sodium Hydroxide / Q000737:chemistry; D013696:Temperature; D014465:Ultrasonics
D011725:Pyridines; D011743:Pyrimidines; D012972:Sodium Hydroxide
Multicomponent reaction (MCR); NaOH; Pyrimidine/pyridine derivatives; Ultrasound