The clinical course of hepatitis E virus infection in patients of a tertiary Dutch hospital over a 5-year period.
BACKGROUND
Hepatitis E virus (HEV) has long been known as a major cause of acute hepatitis in developing countries with occasional travel-related cases in developed countries, most of them belonging to genotype 1. Currently, genotype 3 HEV is recognized as an emerging public health issue in developed countries and can cause a chronic hepatitis in immunocompromised patients.


OBJECTIVE
The aim of this study was to get an overview of the clinical course of HEV infection, from July 2007 to December 2012, and further characterize HEV in patients of the University Medical Center Groningen (UMCG) over a 5-year time period.


METHODS
Since the second half of 2007, patients in the UMCG with unexplained hepatitis were screened for HEV and clinical data were collected. HEV was characterized by sequencing of the ORF1 and ORF2 regions.


RESULTS
In total, 34 patients of the 1129 tested patients showed HEV viremia. The majority of the infected patients were immunocompromised; 18 were solid organ transplant (SOT) patients and 9 were patients immunocompromised for other reasons. Seven patients diagnosed with HEV were immunocompetent. Viral genotyping revealed genotype 3 isolates, mostly genotype 3c.


CONCLUSIONS
Non-travel related HEV hepatitis is an important diagnosis. In immunocompromised patients HEV infection often has major clinical impact, necessitating medical intervention including antiviral treatment. In immunocompetent patients, the detection could expand our understanding about the route of transmission and the relation with the zoonotic origin. Therefore, besides an increasing awareness for HEV among clinicians and medical microbiologists, diagnostics should be routinely incorporated into standard patients care.
Department of Medical Microbiology, Division of Clinical Virology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: a.riezebos@umcg.nl.
Annelies
A
Riezebos-Brilman
Erik A M
EA
Verschuuren
Willem J
WJ
van Son
Gustaaf W
GW
van Imhoff
Johan
J
Brügemann
Hans
H
Blokzijl
Hubert G M
HG
Niesters
D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D016751:Hepatitis E / Q000473:pathology* / Q000821:virology; D016752:Hepatitis E virus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009426:Netherlands; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D062606:Tertiary Care Centers; D055815:Young Adult
D012367:RNA, Viral
ALT; Chronic infection; Diagnostcs; HEV; Hepatitis E virus; Immunocompromised patients; ORF; RT-PCR; SCT; SOT; Treatment; Tx; alanine aminotransferase; hepatitis E virus; open reading frame; reverse transcription polymerase chain reaction; solid organ transplantation; stem cell transplantation; transplantation