Early osseointegration of a strontium containing glass ceramic in a rabbit model.
The most important property of a bone cement or a bone substitute in load bearing orthopaedic implants is good integration with host bone with reduced bone resorption and increased bone regeneration at the implant interface. Long term implantation of metal-based joint replacements often results in corrosion and particle release, initiating chronic inflammation leading onto osteoporosis of host bone. An alternative solution is the coating of metal implants with hydroxyapatite (HA) or bioglass or the use of bulk bioglass or HA-based composites. In the above perspective, the present study reports the in vivo biocompatibility and bone healing of the strontium (Sr)-stabilized bulk glass ceramics with the nominal composition of 4.5SiO2-3Al2O3-1.5P2O5-3SrO-2SrF2 during short term implantation of up to 12 weeks in rabbit animal model. The progression of healing and bone regeneration was qualitatively and quantitatively assessed using fluorescence microscopy, histological analysis and micro-computed tomography. The overall assessment of the present study establishes that the investigated glass ceramic is biocompatible in vivo with regards to local effects after short term implantation in rabbit animal model. Excellent healing was observed, which is comparable to that seen in response to a commercially available implant of HA-based bioglass alone.
Histopathology Laboratory, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695012, India.
Arumugan
A
Sabareeswaran
Bikramjit
B
Basu
Sachin J
SJ
Shenoy
Zahira
Z
Jaffer
Naresh
N
Saha
Artemis
A
Stamboulis
D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005260:Female; D005269:Femur / Q000601:surgery; D006882:Hydroxyapatites / Q000737:chemistry; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration; D011817:Rabbits; D013324:Strontium / Q000737:chemistry*
D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D006882:Hydroxyapatites; C568819:hydroxyapatite-bioglass; C023506:Glass ceramics; D013324:Strontium
Bioglass; In vivo Biocompatibility; Micro-CT; Orthopaedic; Osteoporosis; Strontium