Identification of two severe fever with thrombocytopenia syndrome virus strains originating from reassortment.
Recently, a novel bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV), was isolated in central China. The virus can cause multi-clinical symptoms: severe fever, thrombocytopenia, leukocytopenia, with a mortality rate of ~10%. Several studies show that SFTSV could undergo rapid evolution via gene mutation and homologous recombination. However, as an important evolutionary force for segmented-genome viruses, reassortment has not been reported in SFTSV. In this study, we identified two SFTSV strains of which the S segment has different origin from M and L, suggesting that reassortment might be potential force driving rapid change of SFTSV. This result might shed new light on the evolutionary behavior of the novel virus.
College of Life Science, Shandong Normal University, Jinan 250014, China.
Nai-Zheng
NZ
Ding
Zhi-Fei
ZF
Luo
Dan-Dan
DD
Niu
Wei
W
Ji
Xiu-Han
XH
Kang
Si-Si
SS
Cai
Dong-Shuai
DS
Xu
Qiu-Wen
QW
Wang
Cheng-Qiang
CQ
He
D002681:China; D016000:Cluster Analysis; D019295:Computational Biology; D006801:Humans; D016856:Phlebovirus / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification* / Q000235:genetics*
Reassortment; Severe fever with thrombocytopenia syndrome virus