TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts.
OBJECTIVE
The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived cohort, but not in Middle Eastern patients is investigated in two other populations.


METHODS
Two cohorts of BD patients and controls from Turkey (n=797) and Italy (n=633) were genotyped by sequence specific primer-polymerase chain reaction (SSP-PCR) or TaqMan q-PCR assays.


RESULTS
Genotype and allele frequencies in TIRAP S180L (rs8177374) were not different between BD patients and controls in either ethnicity. Furthermore, a meta-analysis between the Turkish and the Italian BD cohorts did not reveal an association between this non-synonymous SNP in TIRAP and BD (meta-analysis OR=0.94, meta-analysis p=0.61, Q statistic heterogeneity p=0.11).


CONCLUSIONS
TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study.
Department of Physiology, Istanbul University, Istanbul Medical Faculty, Turkey. gorkem1988@hotmail.com.
Gorkem
G
Turunc
Doga
D
Coskun
Fatma
F
Alibaz-Oner
Patrick
P
Coit
Nursen
N
Duzgun
Erkan
E
Alpsoy
Sibel P
SP
Yentur
Carlo
C
Salvarani
Bruno
B
Casali
Ina
I
Kötter
Tulin
T
Ergun
Haner
H
Direskeneli
Amr H
AH
Sawalha
Guher
G
Saruhan-Direskeneli
D000328:Adult; D001528:Behcet Syndrome / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
D008562:Membrane Glycoproteins; D017472:Receptors, Interleukin-1; C434984:TIRAP protein, human