Frequency & specificity of RBC alloantibodies in patients due for surgery in Iran.
OBJECTIVE
Red blood cell alloimmunization is common in patients receiving multiple blood transfusions. Since the probability of repeat transfusion increases with longer life expectancy, it is important to study to which extent alloimmunized patients with a history of transfusion are prone to form alloantibodies after transfusion events. The aim of this study was to retrospectively analyze the alloimmunization against RBCs among transfused patients who were to undergo elective surgery in Tehran, Iran.


METHODS
A total of 3092 occasionally transfused patients, who were to undergo elective surgery, in four hospitals in Tehran were included in the study. For patients with alloantibodies, the data about sex, date of birth, history of transfusion, surgery, abortion and alloantibody specificity were collected.


RESULTS
Clinically significant alloantibodies were found in 30 patients. The presence of positive antibodies in the patients for whom cross-match had been done was one per cent. Most of them had surgery history or transfusion record during the preceding year. The three most frequent alloantibodies were anti-K (23.53%), anti- E (20.59%) and anti-c (17.56%).


CONCLUSIONS
The most common clinically significant alloantibodies identified in men and women were anti-K and anti-E, respectively. The most common causes of alloimmunization for men were surgery history and transfusion record and for women pregnancy.
Medical Laboratory Hematology & Blood Banking Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences/Pediatric Congenital Hematologic Disorders Research Center/Blood Transfusion Research Center, High Institute for Research & Education in Transfusion Medicine, Tehran, Iran.
Khademi
K
Reyhaneh
Gharehbaghian
G
Ahmad
Karimi
K
Gharib
Vafaiyan
V
Vida
Khademi
K
Raheleh
Tabrizi Namini
TN
Mehdi
D000918:Antibody Specificity; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007492:Iran; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D013514:Surgical Procedures, Operative
D007518:Isoantibodies