Prognosis of primary aldosteronism in Japan: results from a nationwide epidemiological study.
The Research Committee of Disorders of Adrenal Hormones, Japan, undertook a nationwide epidemiological study of primary aldosteronism (PA). The present study was undertaken as a part of this study to reveal the relationship between type of treatment and the prognosis of PA. In the primary survey, 4161 patients with PA during the period January 1, 2003-December 31, 2007 were reported from 3252 departments of internal medicine, pediatrics and urology. In the secondary survey, a questionnaire that requested detailed clinical information on individual patients was sent to those departments reporting patients in the primary survey. In total, data on 1706 patients with PA were available in the present study. Among patients with bilateral or unilateral aldosterone-producing adenoma, after adjustment for age at which prognosis was examined, sex, surgical treatment and medical treatment, surgical treatment was significantly associated with amelioration of hypertension (adjusted odds ratio [OR]: 0.47 [95% confidence interval (CI): 0.29-0.77]) and hypokalemia (adjusted OR: 0.17 [95% CI: 0.11-0.29]). No significant relationship was observed between medical treatment and such prognosis in this group of patients. Among patients with bilateral or unilateral adrenal hyperplasia, surgical, but not medical, treatment was significantly associated with amelioration of hypokalemia (adjusted OR: 0.23 [95% CI: 0.06-0.74]), while there was no relationship between surgical or medical treatment and the prognosis of hypertension. In conclusion, surgery offered a better prognosis of PA than medication with regards to hypertension and hypokalemia, with the limitation that a new anti-aldosterone drug, eplerenone, was not available during the study period.
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Yoshihiro
Y
Miyake
Keiko
K
Tanaka
Tetsuo
T
Nishikawa
Mitsuhide
M
Naruse
Ryoichi
R
Takayanagi
Hironobu
H
Sasano
Yoshiyu
Y
Takeda
Hirotaka
H
Shibata
Masakatsu
M
Sone
Fumitoshi
F
Satoh
Masanobu
M
Yamada
Hajime
H
Ueshiba
Takuyuki
T
Katabami
Yasumasa
Y
Iwasaki
Hirotoshi
H
Tanaka
Yusuke
Y
Tanahashi
Shigeru
S
Suzuki
Tomonobu
T
Hasegawa
Noriyuki
N
Katsumata
Toshihiro
T
Tajima
Toshihiko
T
Yanase
D000236:Adenoma / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis; D016021:Epidemiologic Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D006965:Hyperplasia; D006973:Hypertension / Q000150:complications / Q000628:therapy; D007008:Hypokalemia / Q000150:complications / Q000628:therapy; D007564:Japan / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D011795:Surveys and Questionnaires; D015384:Zona Glomerulosa / Q000473:pathology
D000450:Aldosterone