Mean platelet volume is elevated in patients with low high-density lipoprotein cholesterol.
A low high-density lipoprotein cholesterol (HDL-C) level is a predictor of increased cardiovascular risk. We assessed the mean platelet volume (MPV) in patients with low HDL-C. We studied 59 patients with low HDL-C (HDL-C ≤35 mg/dL) and 56 control participants (HDL-C levels >35 mg/dL) with similar cardiovascular risk factors. As expected, HDL-C was significantly lower among the patients with low HDL-C than that of the control group (32 ± 3 vs 51 ± 5 mg/dL, respectively; P < .001). Platelet count was significantly lower among the patients with low HDL-C than that of the control group (213 ± 60 vs 285 ± 75 × 10(9)/L, respectively; P < .001). The MPV was significantly higher among the patients with low HDL-C than that of the control group (8.7 ± 0.6 vs 7.1 ± 0.5 fL, respectively; P < .001). We have shown that MPV was significantly elevated in patients with low HDL-C compared with control participants.
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey drercanvarol@yahoo.com.
Ercan
E
Varol
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Fatih
F
Aksoy
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Hasan Aydin
HA
Bas
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Hatem
H
Ari
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Mehmet
M
Ozaydin
D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count; D011237:Predictive Value of Tests; D012307:Risk Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL
high-density lipoprotein cholesterol; mean platelet volume; platelet activation