Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A.
Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.
International Centre for Research in Infectious diseases, INSERM U1111, University of Lyon, Lyon, France.
P
P
Martins Simões
J-P
JP
Rasigade
H
H
Lemriss
M
M
Butin
C
C
Ginevra
S
S
Lemriss
R V
RV
Goering
A
A
Ibrahimi
J C
JC
Picaud
S
S
El Kabbaj
F
F
Vandenesch
F
F
Laurent
D001151:Arsenic / Q000494:pharmacology; D002104:Cadmium / Q000494:pharmacology; D002876:Chromosomes, Bacterial / Q000235:genetics; D003300:Copper / Q000494:pharmacology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D018805:Sepsis / Q000382:microbiology*
D002104:Cadmium; D003300:Copper; D001151:Arsenic