Thyroid follicular adenoma with accumulation of collagen type IV in a common marmoset (Callithrix jacchus).
A thyroid tumour was identified in a 10-year-old male common marmoset (Callithrix jacchus). The tumour was encapsulated by fibrous connective tissue and compressed the adjacent normal thyroid. The tumour was composed of variably sized and irregularly shaped thyroid follicles lined by a single layer of columnar epithelial cells. Eosinophilic material at the base of the neoplastic cells stained black with periodic acid-methenamine silver and red with periodic acid-Schiff. Immunohistochemistry confirmed that this eosinophilic material was collagen type IV. Ultrastructurally, highly dense and amorphous material was observed at the base of the neoplastic cells. Small vesicles in the basolateral cytoplasm of the neoplastic cells contained similar material to that at the base of the cells. The tumour was diagnosed as a thyroid follicular adenoma with accumulation of collagen type IV. This is the first description of an endocrine tumour with accumulation of collagen type IV in animals.
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan. Electronic address: kawasako.kazufumi@mx.medience.co.jp.
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Kawasako
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan.
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Doi
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan.
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Kanno
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan.
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Wako
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan.
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Hamamura
Pathology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medicine Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0225, Japan.
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Tsuchitani
D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002144:Callithrix; D024141:Collagen Type IV / Q000378:metabolism*; D008297:Male; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
D024141:Collagen Type IV
basement membrane; collagen type IV; common marmoset; thyroid follicular adenoma