Prevalence and factors related to hepatitis B and C infection in inflammatory bowel disease patients in China: a retrospective study.
OBJECTIVE
The objectives of this retrospective study were to assess the prevalence of HBV and HCV infection in Chinese IBD patients, identify potential risk factors of the infection in this population, and discuss the prevalence of HBV and HCV in the general Chinese population.


METHODS
A total of 714 IBD patients who had been investigated for HBV and/or HCV infection were consecutively enrolled in the study. Clinical and laboratory data on IBD and hepatitis infection were collected. A control group of 22,373 healthy individuals was also included in the study.


RESULTS
Present and past HBV infection was found in 40.62% of IBD patients (ulcerative colitis: HBsAg+, 5.68%; anti-HBc+, 41.64%; Crohn's disease: HBsAg+, 5.29%; anti-HBc+, 39.80%;), and 27.58% of the non-IBD group (HBsAg+, 5.52%; anti-HBc+, 27.58% [P = 0.00]). HCV infection was found in 0.42% of IBD patients and 0.36% of the non-IBD group (P=0.80). One hundred and fifty-four of the IBD patients (21.57%) had been effectively vaccinated for HBV. In a multivariate analysis, age, family history of hepatitis B, and IBD-related admission were significantly related to HBV infection in IBD patients. Potential risk factors for HCV were not analyzed due to the limited number of HCV-positive patients in the study.


CONCLUSIONS
Prevalence of HBV infection in IBD patients was higher than that in the non-IBD patients, whereas prevalence of HCV infection was similar to that of the non-IBD group. Effective vaccination for HBV was present in only a small proportion of IBD patients.
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China.
Mei Lan
ML
Huang
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China.
Xi Tao
XT
Xu
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China.
Jun
J
Shen
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China.
Yu Qi
YQ
Qiao
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China.
Zhang Han
ZH
Dai
Department of Gastroenterology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, 160# Pu Jian Ave., 200127 Shanghai, China. Electronic address: zhihuaran@vip.163.com.
Zhi Hua
ZH
Ran
D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000150:complications / Q000821:virology; D003424:Crohn Disease / Q000150:complications / Q000821:virology; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D017325:Hepatitis B Vaccines / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
D017325:Hepatitis B Vaccines
Crohn's disease; Hepatitis B; Hepatitis C; Inflammatory bowel disease; Ulcerative colitis