Systemic lupus erythematosus: immunopathogenesis and novel therapeutic targets.
Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.
SOD Medical Pathology, Center for Autoimmune Systemic Diseases, Behcet Center and Lupus Clinic, AOU Careggi, Florence, Italy.
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Beccastrini
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D'Elios
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Silvestri
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Squatrito
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Prisco
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D056704:Adaptive Immunity / Q000187:drug effects*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D058990:Molecular Targeted Therapy; D012307:Risk Factors; D016896:Treatment Outcome
D007155:Immunologic Factors