Intercellular protein expression variability as a feature of stem cell pluripotency.
The expression of pluripotent stem cell protein markers, self-renewal, the potential to differentiate in cell types of all three germlines and teratoma formation in nude mice form the spectrum of the stringent pluripotency criteria for human stem cells. Currently, intercellular variability is discussed as an additional putative defining property of pluripotent stem cells. In future, it will be of relevance to clarify the genesis of intercellular variability for each stem cell line/population before its application in basic science or therapy. Furthermore, for a better understanding of stemness it will be indispensable to separately investigate the issue of intercellular variability for each feature of pluripotency.
Margit
M
Rosner
Markus
M
Hengstschläger
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D011506:Proteins