DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months.
Cadmium (Cd) is a toxic heavy metal and chronic exposure causes kidney injury. This study used DNA microarray analysis to examine gene expression in the kidney of mice chronically exposed to Cd. Female C57BL/6J mice were fed a 300 ppm Cd-containing diet or a control diet for 12 months. In comparison with control mice, the expression levels of 32 genes, including Hmox1 and Mt2, were elevated more than 2.0-fold, whereas 113 genes, including transport- and ubiquitination-related genes, were reduced less than 0.5-fold.
Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University.
Maki
M
Tokumoto
Jin-Yong
JY
Lee
Yasuyuki
Y
Fujiwara
Masahiko
M
Satoh
D000818:Animals; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000235:genetics*; D008565:Membrane Proteins / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects*
D019187:Cadmium Compounds; D008565:Membrane Proteins; C491054:Mt2 protein, mouse; D008668:Metallothionein; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse