Palladium-catalyzed asymmetric addition of diarylphosphines to α,β-unsaturated sulfonic esters for the synthesis of chiral phosphine sulfonate compounds.
Highly stereoselective addition of diarylphosphines to α,β-unsaturated sulfonic esters catalyzed through a PCP pincer-Pd complex is developed to synthesize chiral phosphine sulfonic esters with excellent enantioselectivity (up to 99.5% ee). The transformation of the chiral adduct into a useful palladium phosphine sulfonate complex is also demonstrated.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , Chinese Academy of Sciences, 345 LingLing Road, Shanghai 200032, China, and School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
Junzhu
J
Lu
Jinxing
J
Ye
Wei-Liang
WL
Duan
D002384:Catalysis; D004952:Esters; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D004952:Esters; D009943:Organophosphorus Compounds; D010720:Phosphines; D013451:Sulfonic Acids; D010165:Palladium; C044646:phosphine