[Study on preparation process and stability of beta-cyclodextrin inclusion compound in volatile oil of Cinnamomum longepaniculatum leaves].
To study the optimum preparation process and stability of beta-cyclodextrin inclusion compound in volatile oil of Cinnamomum longepaniculatum leaves. The saturated aqueous solution method was adopted to prepare inclusion compounds for an orthogonal test. The inclusion compound productivity and the inclusion rate were taken as indexes for screening the inclusion processes. The inclusion effect was evaluated with the infrared spectrophotometry and TLC, and the stability under conditions of high temperature, high humidity and strong light was detected. Under optimum preparation conditions for inclusion, the ratio between volatile oil and beta-cyclodextrin was 1: 8 (mL: g), that between beta-cyclodextrin and water was 1: 15, the inclusion temperature was 40 degrees C, and the inclusion time was 3 h. The results of spectrophotometry and TLC showed that the optimum conditions can generate beta-cyclodextrin inclusion compound in volatile oil of C. longepaniculatum leaves with certain light resistance, thermo-stability and hygro-stability. Therefore the optimum inclusion process features simple operation and stable inclusion compounds.
College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Yu
Y
Liu
Zhong-Qiong
ZQ
Yin
Qin
Q
Wei
Ren-Yong
RY
Jia
Jing
J
Fan
Li-Jun
LJ
Zhou
Yong-Hua
YH
Du
D002855:Chromatography, Thin Layer; D027424:Cinnamomum / Q000737:chemistry*; D004355:Drug Stability; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013678:Technology, Pharmaceutical; D047392:beta-Cyclodextrins / Q000737:chemistry*
D009822:Oils, Volatile; D047392:beta-Cyclodextrins