Antibacterial hydrogel coating by electrophoretic co-deposition of chitosan/alkynyl chitosan.
Despite much effort has been paid to develop aseptic implant devices, the infection associated with medical implant still remains a significant problem. Here, we report a potential coating material derived from a natural biopolymer chitosan. Firstly, chitosan functionalized with alkynyl moiety (ACS) was prepared by reaction between chitosan and 3-bromopropyne. The structure of the alkynyl chitosan was characterized by FT-IR, (1)H NMR, XRD, TGA and element analysis. The minimum inhibitory concentration (MIC) of ACS with a degree of substitution (DS) of 0.40 was 0.03% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Subsequently, the alkynyl chitosan was co-deposited with chitosan on stainless steel wire to fabricate a composite hydrogel. The composite hydrogel exhibited better antibacterial activities than pure chitosan hydrogel.
School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
Fuyuan
F
Ding
Zhen
Z
Nie
Hongbing
H
Deng
Ling
L
Xiao
Yumin
Y
Du
Xiaowen
X
Shi
D000480:Alkynes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D004586:Electrophoresis; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D020100:Hydrogels; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013193:Stainless Steel; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000480:Alkynes; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D020100:Hydrogels; D013193:Stainless Steel; D048271:Chitosan
Alkynyl chitosan; Antibacterial activity; Chitosan; Composite hydrogel; Electrophoretic co-deposition