Synthesis, antimicrobial evaluation and QSAR studies of stearic acid derivatives.
A series of Schiff bases (1-17) and esters (18-28) of stearic acid was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity by tube dilution method. The antimicrobial screening results indicated that the compounds having electron releasing groups on benzylidene nucleus were found to be more active against bacterial strains and compounds having electron withdrawing groups on benzylidene nucleus were found to be more active against fungal strains. QSAR studies demonstrated that electronic parameters dipole moment (µ) and total energy (Te) were the most important descriptors in describing the antimicrobial activity of synthesized stearic acid derivatives.
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
S
S
Tahlan
Pharmaceutical Sciences, Dayanand University, Rohtak, India.
P
P
Kumar
Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
B
B
Narasimhan
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship; D013229:Stearic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D013229:Stearic Acids