Palladium-catalyzed methylation of alkynyl C(sp)-H bonds with dimethyl sulfonium ylides.
A novel palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes has been established. This methylation method is achieved through a C(sp)-C(sp(3)) bond formation process and represents a new synthetic application of sulfonium ylides.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
Yan-Yun
YY
Liu
Xu-Heng
XH
Yang
Xiao-Cheng
XC
Huang
Wen-Ting
WT
Wei
Ren-Jie
RJ
Song
Jin-Heng
JH
Li
D000480:Alkynes / Q000737:chemistry*; D006860:Hydrogen Bonding; D008745:Methylation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013452:Sulfonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
D000480:Alkynes; D013452:Sulfonium Compounds; D010165:Palladium