[Serum leptin, adiponectin, visfatin levels in adult GHD patients and correlation studies].
OBJECTIVE
To investigate the change of leptin, adiponectin and visfatin levels in adult growth hormone deficiency (GHD) patients, and its relationship with other indicators.


METHODS
40 adult GHD patients (19 males) entered the observation group with 36 cases of healthy individuals (18 males) as the control group. Basic information (height, body mass, waistline, hipline etc.) was collected from both groups. Fasting venous blood samples were collected to measure the leptin, adiponectin and visfatin levels.


RESULTS
The GHD group had a higher waist to hip ratio, and higher levels of cholesterol, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), leptin, adiponectin and visfatin, but lower levels of growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and dehydroepiandrosterone sulfate (DHEA-S) when campared with that of the control group (P < 0.05). Logistic regression analysis demonstrated that adult GHD patients are associated with elevated levels of visfatin (OR = 1. 430, P < 0.05).


CONCLUSIONS
Our study implied that adult GHD patients are associated with elevated levels of visfatin.
Department of General Practice, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhi-Peng
ZP
Li
Ting
T
Zhang
Guo-Yan
GY
Zhou
Jie
J
Gao
Shuang-Qing
SQ
Li
Zhen-Mei
ZM
An
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D003677:Deficiency Diseases / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D055815:Young Adult
D052242:Adiponectin; D020738:Leptin; D013006:Growth Hormone; D054409:Nicotinamide Phosphoribosyltransferase