Molecular mechanisms and cell targets of Th17 cells in the gastrointestinal tract: an innate sense of adaptivity.
T-helper (TH) 17 activation is crucial for protective immune responses against bacteria and fungi at mucosal surfaces, but it can also be implicated in the pathogenesis of several autoimmune and chronic inflammatory diseases, such as inflammatory bowel diseases (IBD). Although rapid progress was made elucidating induction and functional heterogeneity of Th17 responses, the underlying molecular effects of Th17 response including the most relevant different cell targets of Th17 cytokines remain poorly understood. Cytokines produced by Th17 cells have broad effects on both hematopoietic and nonhematopoietic cells and can act in synergy with various inflammatory factors. In this review, we will focus on the effects of Th17-derived cytokines in the gastrointestinal tract and discuss how Th17 responses can affect both innate and adaptive immunity and may contribute to the pathogenesis of inflammatory GI processes.
Institut National de la Santé et de la Recherche Médicale (INSERM) , UMR989, Paris , France.
Julien
J
Verdier
Frank M
FM
Ruemmele
D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines