New eremophilane-type sesquiterpenes from an Antarctic deepsea  derived fungus, Penicillium sp. PR19 N-1.
Chemical investigation of an Antarctic deepsea derived fungus Penicillium sp. PR19 N-1 yielded five new eremophilane-type sesquiterpenes 1–5 and a new rare lactam-type eremophilane 6, together with three known compounds 7–9. The structures of these diverse sesquiterpenes were determined by extensive NMR and mass spectroscopic analyses. Compounds 1, 2, 4–6, 8 and 9 were evaluated for their cytotoxities against HL-60 and A-549 human cancer cell lines, and 5 was the most active one with IC50 value of 5.2 lM against the A-549 cells.
Aiqun
A
Lin
Guangwei
G
Wu
Qianqun
Q
Gu
Tianjiao
T
Zhu
Dehai
D
Li
D000864:Antarctic Regions; D061006:Bays / Q000382:microbiology*; D005658:Fungi; D019015:Geologic Sediments / Q000382:microbiology*; D018922:HL-60 Cells; D006801:Humans; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification*; D010407:Penicillium; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D009281:Naphthalenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds