Decreased sudomotor function is involved in the formation of atopic eczema in the cubital fossa.
BACKGROUND
Eczema in the cubital fossa, which is susceptible to sweat, is frequently observed in atopic dermatitis (AD). However, there has been no direct evidence that sweating causes eczema in the cubital fossa.


METHODS
To investigate this issue, axon reflex-mediated sweating volume (AXR) and skin barrier function in the cubital fossa were measured in subjects with AD and in healthy volunteers, and were applied to clinical feature of the cubital fossa.


RESULTS
AXR in the cubital fossa decreased in AD subjects; it positively correlated only with water-holding capacity in healthy subjects but not in patients with in AD. Furthermore, AD subjects with lichenoid eczema and either prurigo or papules over the cubital fossa showed extremely decreased AXR.


CONCLUSIONS
These results suggest that decreased sweating is a major source of water in the stratum corneum, and decreased sudomotor function may be involved in both the cause and aggravation of representative atopic eczema in the cubital fossa.
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Aya
A
Takahashi
Hiroyuki
H
Murota
Saki
S
Matsui
Akiko
A
Kijima
Shun
S
Kitaba
Jeong-Beom
JB
Lee
Ichiro
I
Katayama
D000293:Adolescent; D000328:Adult; D001369:Axons / Q000276:immunology; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology*; D004485:Eczema / Q000209:etiology / Q000276:immunology*; D004550:Elbow / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012018:Reflex / Q000276:immunology; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D013542:Sweat / Q000378:metabolism*; D013546:Sweating / Q000276:immunology; D055815:Young Adult