Effect of local application of aminoguanidine on the biomechanical retention of implants in rats with induced diabetes.
OBJECTIVE
To evaluate the effect of surgical placement of an aminoguanidine (AG)-loaded chitosan membrane, which allows slow local release of AG, over an endosseous implant on mechanical retention of the implant in nondiabetic and diabetic rats.


METHODS
Forty-eight male Wistar rats were randomly divided into six groups of eight animals each and subjected to three different treatment modalities: (1) implant placement in the femur, (2) placement of implant + chitosan membrane without AG at the surgical site, or (3) placement of implant + AG-loaded chitosan membrane (AG concentration of 7.35 mmol/kg body weight) at the surgical site. Groups 1, 2, and 3 were nondiabetic (control groups), and groups 4, 5, and 6 had chemically induced type 1 diabetes (test groups). At 4 weeks after implant placement, the animals were sacrificed and the countertorque force (CTF) required to disrupt the bone-implant interface was measured. Analyses of variance were performed, and the mean CTF values were compared between groups by using the Student t test.


RESULTS
The mean CTF values were significantly lower in diabetic groups not treated with AG than in the corresponding nondiabetic animals that had received the same treatment modality. In groups that received AG locally, the mean CTF values were not statistically significantly different, regardless of diabetes status.


CONCLUSIONS
Induced diabetes (type 1) negatively affected the CTF necessary for disrupting the bone-implant interface. Local availability of AG in diabetic animals led to an increase in the CTF values to the same level as that in nondiabetic animals.
Gabriel Faria
GF
Aiala
Alcione Maria Soares Dutra
AM
Oliveira
Fernando Oliveira
FO
Costa
Denise Ligório
DL
Fialho
Armando Silva
AS
Cunha
Peterson Antônio Dutra
PA
Oliveira
D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants / Q000009:adverse effects; D017268:Dental Prosthesis Retention; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000503:physiopathology; D004343:Drug Implants; D005269:Femur; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019415:Torque
D015921:Dental Implants; D004343:Drug Implants; D006146:Guanidines; C004479:pimagedine