Intestinal aGVHD and infection after hematopoietic stem cell transplantation.
BACKGROUND
We aimed to guide clinical nursing by studying the relationship between intestinal acute graft-versus-host disease and intestinal infection after hematopoietic stem cell transplantation.


METHODS
We present an effective nursing method by comparing and analyzing the degree, duration time, and volume of diarrhea, and the distribution of pathogens in 44 patients who developed intestinal aGVHD after hematopoietic stem cell transplantation (24 patients with no intestinal infection).


RESULTS
21.4% of patients with grade I-II intestinal aGVHD developed into intestinal infection and 87.5% of patients with grade III-IV intestinal aGVHD developed into intestinal infection (P<0.05). Higher mortality was found in the grade III-IV intestinal aGVHD patients with intestinal infection. Patient age had no effect on the incidence of GVHD according to our data (P<0.05). We found remarkable differences in the amount and duration of diarrhea between patients with and without intestinal infection (P<0.05). The most common pathogens cultivated were Candida glabrata (24%) and Candida albicans (22.67%).


CONCLUSIONS
The incidence of intestinal infection increased remarkably after intestinal aGVHD occurred. Severe aGVHD can easily lead to fungus infection. Nursing care can decrease the incidence of intestinal infection in aGVHD.
The 307th Hospital of PLA, Beijing,China.
Cai-yan
CY
Hou
Li-li
LL
Xu
Hu
H
Chen
Na
N
Liu
Ming
M
Jiang
Guo-quan
GQ
Wang
Linlin
L
Zhang
Xiao-hong
XH
Wang
Yan-jun
YJ
Zeng
D000293:Adolescent; D000328:Adult; D058365:Candidiasis, Invasive / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D002681:China; D003967:Diarrhea / Q000209:etiology / Q000451:nursing* / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000175:diagnosis; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors