Application of [18F]FDG in radiolabeling reactions using microfluidic technology.
Radiolabeling of peptides with the short-lived positron emitter fluorine-18 is usually a challenging endeavour. Conventional radiolabeling reactions mostly require fairly large amounts of peptides as labeling precursors, and extensive synthesis times. Intrinsic advantages of microfluidic technology permit to overcome these hurdles. Herein, we describe how microfluidic technology combined with [(18)F]FDG as readily available PET radiotracer allows for fast and high yielding radiolabeling reactions of peptides with fluorine-18.
Department of Oncology, University of Alberta, Edmonton, AB, Canada. wuest@ualberta.ca.
Vincent R
VR
Bouvet
Frank
F
Wuest
D019788:Fluorodeoxyglucose F18 / Q000737:chemistry*; D007553:Isotope Labeling; D046210:Microfluidic Analytical Techniques; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D010455:Peptides; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18