Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution.
The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.
Royal Institute of Technology, Department of Chemistry, Teknikringen 30, Stockholm, Sweden. ramstrom@kth.se.
Lei
L
Hu
Fredrik
F
Schaufelberger
Yan
Y
Zhang
Olof
O
Ramström
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D004798:Enzymes; D005656:Fungal Proteins / Q000378:metabolism*; D007700:Kinetics; D019259:Lamivudine / Q000138:chemical synthesis* / Q000737:chemistry; D008049:Lipase / Q000378:metabolism*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D004798:Enzymes; D005656:Fungal Proteins; D019259:Lamivudine; D008049:Lipase; C431349:lipase B, Candida antarctica