Early surfactant for respiratory distress syndrome in premature infants.
Effects of early surfactant administration to premature newborns have been widely investigated in several RCTs. Furthermore, recent studies and metanalysis have compared early with delayed administration as well as selective and prophylactic use of surfactant. These data from the literature are discussed in the present review together with the factors that may argue against the standardization of respiratory care at birth. A tailored approach based on the stratification of risk factors may be appropriate in the so heterogeneous population of premature newborns.
Neonatal Intensive Care Unit, Istituto Giannina Gaslini, Via Gaslini 5, 16148 Genova, Italy. fabio.scopesi@yahoo.it
Fabio
F
Scopesi
Alessandro
A
Parodi
Anna R
AR
Natalizia
Andrea
A
Sannia
Luca A
LA
Ramenghi
D045422:Continuous Positive Airway Pressure; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D061665:Time-to-Treatment
D011663:Pulmonary Surfactants