The clinical implications of ADAMTS13 function: the perspectives of haemostaseologists.
Apart from TTP, ADAMTS13 may be an important player in those conditions where Von Willebrand Factor and the Platelet Glycoprotein GP Ib axis have a part to play in the pathogenesis. This includes stroke, myocardial infarction, sepsis and inflammatory condition. This article reviews the literature in these conditions.
Centre for Haemostasis & Thrombosis, Guy's & St Thomas' NHS Foundation Trust, London. Electronic address: savita.rangarajan@gstt.nhs.uk.
Savita
S
Rangarajan
Craig
C
Kessler
Louis
L
Aledort
D051722:ADAM Proteins / Q000097:blood / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000071120:ADAMTS13 Protein; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D014841:von Willebrand Factor / Q000235:genetics / Q000378:metabolism*
D014841:von Willebrand Factor; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human