Anterior cingulate cortex involvement in subclinical social anxiety.
We demonstrated differential activation in the anterior cingulate cortex (ACC) between subjects with high and low social anxiety in response to angry versus neutral faces. Activation in the ACC distinguished between facial expressions in the low, but not the high, anxious group. The ACC's role in threat processing is discussed.
Department of Psychiatry, University of Michigan Health System, 4250 Plymouth Road, Ann Arbor, MI 48109, USA; Department of Psychology, University of Missouri-Kansas City, Kansas City, MO, USA. Electronic address: eduval@med.umich.edu.
Elizabeth R
ER
Duval
Lisa R
LR
Hale
Israel
I
Liberzon
Rebecca
R
Lepping
Joshua
J
N Powell
Diane L
DL
Filion
Cary R
CR
Savage
D000293:Adolescent; D000328:Adult; D000786:Anger; D001007:Anxiety / Q000503:physiopathology*; D001931:Brain Mapping; D005149:Facial Expression; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012792:Shyness; D055815:Young Adult
Backward masking; Faces; fMRI