Association of blood type and patient characteristics with ovarian reserve.
OBJECTIVE
To assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.


METHODS
Cross-sectional study.


METHODS
Academic medical center, Division of Reproductive Endocrinology and Infertility.


METHODS
Women undergoing in vitro fertilization (IVF) from 2006-2011 (n = 305).


METHODS
None.


METHODS
Presence of DOR in relation to a patient's blood type.


RESULTS
Other investigators have reported an increased risk for DOR in patients with blood type O and a protective effect on ovarian reserve for blood type A. We observed no association between a woman's blood type and DOR. We found an increased risk for DOR in patients aged 35 and older. Obesity (BMI ≥ 30 vs. BMI <25) was associated with lower odds of DOR.


CONCLUSIONS
In comparison with blood type A, blood type O is not associated with an increase in DOR. We found no clinical implications for using blood type as a risk factor for DOR.
Wake Forest School of Medicine, Winston-Salem, North Carolina.
Kathryn S
KS
Timberlake
Kristie L
KL
Foley
Bradley S
BS
Hurst
Michelle L
ML
Matthews
Rebecca S
RS
Usadi
Paul B
PB
Marshburn
D000328:Adult; D017677:Age Distribution; D015415:Biomarkers / Q000097:blood; D001788:Blood Grouping and Crossmatching / Q000706:statistics & numerical data*; D015984:Causality; D015897:Comorbidity; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D009765:Obesity / Q000097:blood* / Q000453:epidemiology*; D034445:Ovulation Inhibition; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors
D015415:Biomarkers; D005640:Follicle Stimulating Hormone
Blood type; FSH; infertility; obesity; ovarian reserve