Correlation of paraoxonase1 activities with birth weight.
OBJECTIVE
To evaluate arylesterase and lactonase activity of paraoxonase (PON)1 in cord blood of neonates in relation to their birth weight. The authors hypothesized that cord blood PON1 arylesterase and lactonase activities will be compromised in neonates having low birth weight.


METHODS
Eighty neonates born in authors' hospital, irrespective of mode of delivery were included. Forty children with low birth weight were included in case group and 40 with normal birth weight were included as controls. PON1 arylesterase and lactonase activities were measured.


RESULTS
Serum arylesterase activity decreased significantly in low birth weight babies (p < 0.05). Linear regression analysis (R = 0.728) indicated significant correlation between arylesterase and birth weight. Serum lactonase activity was also reduced in low birth weight babies. Its linear regression analysis (R = 0.727) indicated significant correlation between lactonase and birth weight.


CONCLUSIONS
PON 1 activity is significantly reduced among low birth weight babies in comparison to normal weight babies.
Department of Biochemistry, SRTR Govt Medical College, Ambajogai, 431517, Maharashtra, India.
Mukund Ramchandra
MR
Mogarekar
Mohit Vijay
MV
Rojekar
D043303:Aryldialkylphosphatase / Q000097:blood*; D001724:Birth Weight; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D012044:Regression Analysis
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human