Association of CD36 gene polymorphisms with echo- and electrocardiographic parameters in patients with early onset coronary artery disease.
BACKGROUND
CD36 plays an important role in long-chain fatty acid homeostasis in skeletal muscle and the myocardium. CD36 deficiency may lead to reduced myocardial uptake of long-chain fatty acid. Therefore, different mutations of the CD36 gene may contribute to the clinical heterogeneity of cardiac hypertrophy.


METHODS
The objective of the study was to investigate whether there is an association between the sequence changes in CD36 and echocardiographic and electrocardiographic parameters in Caucasian patients with early onset coronary artery disease. The study group comprised 100 patients. Electrocardiography and echocardiography were performed in all patients. Amplicons of exons 4 to 6 including fragments of introns were studied using the denaturing high-performance liquid chromatography technique.


RESULTS
IVS3-6TC (rs3173798) heterozygotes had impaired left ventricle diastolic function. 573GA heterozygotes (rs5956) had higher frequency of pseudonormal left ventricular diastolic function and it was confirmed by the increase in wave A' in the tissue Doppler. 591AT genotype was associated with borderline higher posterior wall end-diastolic thickness and lower E/A ratio. These results are consistent with electrocardiography parameters which could reflect left ventricular hypertrophy (higher RV5(6) and RV5(6) + SV1(2) parameters, depressed ST segments and tendency to longer Qtc II interval) in 591AT heterozygotes.


CONCLUSIONS
Detected variant alleles of CD36 may be associated with features of left ventricular hypertrophy and impaired diastolic function.
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Monika
M
Rac
Grzegorz
G
Kurzawski
Krzysztof
K
Safranow
Michal
M
Rac
Dagmara
D
Sagasz-Tysiewicz
Andrzej
A
Krzystolik
Wojciech
W
Poncyljusz
Maria
M
Olszewska
Grażyna
G
Dawid
Dariusz
D
Chlubek
CAD; CD36; diastolic function; echocardiography; electrocardiography; left ventricular hypertrophy