Switching the H-bonding network of a foldamer by modulating the backbone chirality and constitutional ratio of amino acids.
This communication describes the folding propensity of a heterofoldamer motif featuring proline (Pro) and anthranilic acid (Ant) residues in a 1:2:1 (α:β:α) constitutional ratio. Structural investigations unequivocally suggest that the hydrogen-bonding network of this foldamer motif can be switched between 9-membered and 6-membered by modulating the backbone chirality and constitutional ratio of the amino acid residues.
Division of Organic Synthesis, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. gj.sanjayan@ncl.res.in.
Veera V E
VV
Ramesh
Kuruppanthara N
KN
Vijayadas
Snehal
S
Dhokale
Rajesh G
RG
Gonnade
Pattuparambil R
PR
Rajamohanan
Gangadhar J
GJ
Sanjayan
D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D062367:ortho-Aminobenzoates / Q000737:chemistry*
D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D011392:Proline