Brain peroxisomes.
Peroxisomes are essential organelles in higher eukaryotes as they play a major role in numerous metabolic pathways and redox homeostasis. Some peroxisomal abnormalities, which are often not compatible with life or normal development, were identified in severe demyelinating and neurodegenerative brain diseases. The metabolic roles of peroxisomes, especially in the brain, are described and human brain peroxisomal disorders resulting from a peroxisome biogenesis or a single peroxisomal enzyme defect are listed. The brain abnormalities encountered in these disorders (demyelination, oxidative stress, inflammation, cell death, neuronal migration, differentiation) are described and their pathogenesis are discussed. Finally, the contribution of peroxisomal dysfunctions to the alterations of brain functions during aging and to the development of Alzheimer's disease is considered.
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Trompier
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Vejux
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France; Université de Monastir, Faculté de Médecine, LR12ES05, Lab-NAFS 'Nutrition - Functional Food & Vascular Health', Avenue Avicenne, Monastir, Tunisia.
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Zarrouk
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Gondcaille
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Geillon
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Nury
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France.
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Savary
Université de Bourgogne, Laboratoire «Bio-PeroxIL» de Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique (EA7270)/INSERM, 6 Bd Gabriel, Dijon F-21000, France. Electronic address: gerard.lizard@u-bourgogne.fr.
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Lizard
D000375:Aging; D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D016923:Cell Death; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement; D003711:Demyelinating Diseases / Q000503:physiopathology; D004660:Encephalitis / Q000503:physiopathology; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism; D018384:Oxidative Stress; D018901:Peroxisomal Disorders / Q000503:physiopathology*; D020675:Peroxisomes / Q000378:metabolism*
Alzheimer's disease; Demyelination; Inflammation; Oxidative stress; Peroxisome disorders