Intragastric administration of glutamate increases REM sleep in rats.
Monosodium glutamate, a umami taste substance is commonly used flavor enhancer. The effect of intragastric administration of 1.5 ml of 0.12M monosodium glutamate on sleep-wake was studied in 10 adult male Wistar rats. Sleep-wake parameters were recorded through chronically implanted electroencephalogram, electrooculogram and electromyogram electrodes using a digital recording system (BIOPAC system Inc. BSL PRO 36, USA). The sleep-wake was recorded for 6h after the intragastric administration of either glutamate or saline. Sleep-wake stages were analyzed as wake, slow wave sleep and REM sleep. Compared to saline, intragastric administration of glutamate significantly increased REM sleep duration and episode frequency. REM sleep duration was increased in all the three 2h bins, 10:00-12:00 h (p=0.037), 12:00-14:00 h (p=0.037) and 14:00-16:00 h (p=0.007). The slow wave sleep and total sleep time were not affected. It is concluded that intragastric glutamate administration increases REM sleep.
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
Karuna
K
Datta
Deependra
D
Kumar
Hruda Nanda
HN
Mallick
D000818:Animals; D004333:Drug Administration Routes; D004569:Electroencephalography; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012895:Sleep, REM / Q000187:drug effects*; D012970:Sodium Glutamate / Q000008:administration & dosage*; D013270:Stomach / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D012970:Sodium Glutamate
Glutamate; Intragastric; Monosodium glutamate; REM sleep