Going from social neuroscience to schizophrenia clinical trials.
The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adapt these paradigms for use in schizophrenia clinical trials, (4) assess the psychometric properties of these measures, and (5) assess the external validity of these measures. The articles in this theme section present the initial findings from the SCAF project. As more training and psychopharmacological studies evaluate interventions for social cognition, the articles in this theme section are intended to serve as a guide for informed design decisions about possible endpoints in clinical trials.
*To whom correspondence should be addressed; 760 Westwood Plaza, Room 77-361, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024-1759, US; tel: 310-268-3376, fax: 310-268-4056, e-mail: mgreen@ucla.edu.
Michael F
MF
Green
David L
DL
Penn
D002986:Clinical Trials as Topic; D006801:Humans; D009488:Neurosciences / Q000295:instrumentation / Q000379:methods; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012919:Social Behavior
clinical trials; schizophrenia; social cognition; social neuroscience