Virological, serological, and antiviral studies in an imported human case of avian influenza A(H7N9) virus in Taiwan.
We describe the clinical course and virological characteristics of the first H7N9 influenza case in a Taiwanese patient; this patient had detectable viruses in the airway for 2 weeks, during which time an oseltamivir resistance-associated R292K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine.
Pi-Han
PH
Lin
Tai-Ling
TL
Chao
Shuenn-Wen
SW
Kuo
Jann-Tay
JT
Wang
Chien-Ching
CC
Hung
Huan-Chun
HC
Lin
Zong-Yu
ZY
Yang
Shu-Yuan
SY
Ho
Chun-Kai
CK
Chang
Ming-Siang
MS
Huang
Hui-Hou
HH
Chen
Yee-Chun
YC
Chen
Hong-Shiee
HS
Lai
Sui-Yuan
SY
Chang
Shan-Chwen
SC
Chang
Pan-Chyr
PC
Yang
D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000187:drug effects* / Q000302:isolation & purification*; D007251:Influenza, Human / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D053139:Oseltamivir / Q000494:pharmacology; D012367:RNA, Viral / Q000235:genetics; D012137:Respiratory System / Q000821:virology; D017422:Sequence Analysis, DNA; D013624:Taiwan; D019562:Viral Load
D000914:Antibodies, Viral; D000998:Antiviral Agents; D012367:RNA, Viral; D053139:Oseltamivir
H7N9; oseltamivir; resistance