Morphology-based plasmonic nanoparticle sensors: controlling etching kinetics with target-responsive permeability gate.
We present a sensing platform based on the morphological changes of plasmonic nanoparticles. Detection is achieved by using a stimulus-responsive polyelectrolyte-aptamer thin film to control the rate of diffusion of etchants that alter the shape and size of the nanoparticles. We show that the extent of morphological change and the colorimetric response depends on the amount of analyte bound. Contrary to conventional plasmonic sensors, our detection scheme does not rely on any interparticle interaction and is completely label-free, both in terms of the analyte and the capture probe. It presents new opportunities for designing facile, low-cost, and portable chip-based sensors for biodiagnostic and field analysis.
Department of Chemistry, York University , 4700 Keele Street, Toronto, Ontario Canada M3J 1P3.
Brian
B
Malile
Jennifer I L
JI
Chen
D052157:Aptamers, Nucleotide; D015374:Biosensing Techniques; D003124:Colorimetry; D007202:Indicators and Reagents; D007700:Kinetics; D053768:Metal Nanoparticles; D008968:Molecular Conformation; D010539:Permeability; D011803:Quinine / Q000737:chemistry; D012235:Rhodamines; D013056:Spectrophotometry, Ultraviolet; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods
D052157:Aptamers, Nucleotide; D007202:Indicators and Reagents; D012235:Rhodamines; C022027:lissamine rhodamine B; D011803:Quinine