The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium.
Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidence suggests that perturbed TLR4 signaling is linked to carcinogenesis. We have recently demonstrated that the common human TLR4 variant D299G exerts pro-inflammatory effects and drives malignant tumor progression in human colon cancer.
Division of Gastroenterology and Hepatology; University Hospital Essen; Medical School, University of Duisburg-Essen; Essen, Germany.
Elke
E
Cario
Toll-like receptors; cancer-associated inflammation; colon cancer; innate immunity; intestinal epithelial cells; lipopolysaccharide; metastasis; pattern-recognition receptors; tumor microenvironment