Clinical decision-making augmented by simulation training: neural correlates demonstrated by functional imaging: a pilot study.
BACKGROUND
Investigation of the neuroanatomical basis of clinical decision-making, and whether this differs when students are trained via online training or simulation training, could provide valuable insight into the means by which simulation training might be beneficial.


METHODS
The aim of this pilot prospective parallel group cohort study was to investigate the neural correlates of clinical decision-making, and to determine if simulation as opposed to online training influences these neural correlates. Twelve third-year medical students were randomized into two groups and received simulation-based or online-based training on anaphylaxis. This was followed by functional magnetic resonance imaging scanning to detect brain activation patterns while answering multiple choice questions (MCQs) related to anaphylaxis, and unrelated non-clinical (control) questions. Performance in the MCQs, salivary cortisol levels, heart rate, and arterial pressure were also measured.


RESULTS
Comparing neural responses to clinical and non-clinical questions (in all participants), significant areas of activation were seen in the ventral anterior cingulate cortex and medial prefrontal cortex. These areas were activated in the online group when answering action-based questions related to their training, but not in the simulation group. The simulation group tended to react more quickly and accurately to clinical MCQs than the online group, but statistical significance was not reached.


CONCLUSIONS
The activation areas seen could indicate increased stress when answering clinical questions compared with general non-clinical questions, and in the online group when answering action-based clinical questions. These findings suggest simulation training attenuates neural responses related to stress when making clinical decisions.
University Division of Anaesthesia, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
S S H
SS
Goon
E A
EA
Stamatakis
R M
RM
Adapa
M
M
Kasahara
S
S
Bishop
D F
DF
Wood
D W
DW
Wheeler
D K
DK
Menon
A K
AK
Gupta
D000328:Adult; D001921:Brain / Q000502:physiology*; D015331:Cohort Studies; D003198:Computer Simulation; D003657:Decision Making; D004501:Education, Medical; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010865:Pilot Projects; D017397:Prefrontal Cortex / Q000502:physiology; D011446:Prospective Studies
computer simulation; magnetic resonance imaging, functional; stress, psychological