Microplates in liquid chromatography--new solution in clinical research? A review.
Microplates are routinely used in Radio- or Immuno-assays. Recently, microplates have found use not only in analytical but also in the pre-analytical phase in bioanalyses (sample storage, sample preparation). New connection of this technology to liquid chromatography could be economical, fast and simple solution for many routine laboratories handling large sequences of biological samples. This review summarises the application of microplates in bioanalytical laboratories. Different types of sorbents, materials and shapes of microplates are discussed, and the main advantages and disadvantages of microplates used in clinical research are presented.
III. Internal Gerontometabolic Clinic, University Hospital, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic. Electronic address: lenkakrcmova@seznam.cz.
Lenka
L
Krcmova
Dagmar
D
Solichova
Petr
P
Solich
D057205:Automation, Laboratory; D035843:Biomedical Research / Q000295:instrumentation*; D002853:Chromatography, Liquid / Q000295:instrumentation*; D006801:Humans; D007755:Laboratories, Hospital; D010969:Plastics; D013048:Specimen Handling / Q000295:instrumentation* / Q000379:methods
D010969:Plastics
Bioanalysis; High throughput analysis; Liquid chromatography; Microplates; Sample preparation