ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines.
A simple and efficient protocol is developed for the synthesis of 2-substituted-4,6-diarylpyrimidines from one-pot three-component reaction of 4'-hydroxy-3',5'-dinitro substituted chalcones, S-benzylthiouronium chloride (SBT), and heterocyclic secondary amines (morpholine/pyrrolidine/piperidine) in the presence of 15 mol% of ZnO as a heterogeneous catalyst. The present methodology offers several advantages such as being a simple procedure as well as providing excellent yields, and short reaction time. The catalyst is inexpensive, stable, and can be easily recycled and reused for several cycles with consistent activity.
Department of Chemistry, Faculty of Arts, Science and Commerce, Mody Institute of Technology & Science, Lakshmangarh 332311, Rajasthan, India.
K L
KL
Ameta
Biresh
B
Kumar
Nitu S
NS
Rathore