Two new constituents from Erigeron breviscapus.
Two novel constituents, named erigeronones A (1) and B (2), together with apigenin-7-O-β-galacturonide (3), quercetin-7-O-β-glucuronide (4), quercetin-3-O-β-galacturonide (5), and eriodictyol-7-O-β-glucuronide (6), were isolated from the whole grass of Erigeron breviscapus (Vant) Hand.-Mazz (Compositae). Their structures were established on the basis of spectral analyses and comparison with the literature data. Both new compounds 1 and 2 possess a γ-pyrone moiety that is rare in nature. Compound 1 showed significant protective effect on H2O2-injured human umbilical vein endothelial cells.
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , 100050 , China.
Jing
J
Li
De-Quan
DQ
Yu
D047310:Apigenin / Q000737:chemistry; D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D049919:Erigeron / Q000737:chemistry; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D005965:Glucuronates / Q000737:chemistry / Q000302:isolation & purification; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011794:Quercetin / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005965:Glucuronates; D011753:Pyrones; C585794:erigeronone A; C585793:erigeronone B; C068767:eriodictyol 7-glucuronide; D047310:Apigenin; D011794:Quercetin; D006861:Hydrogen Peroxide