PrenatalChlamydia trachomatisinfection increases the risk of preeclampsia.
The relationship betweenChlamydia trachomatis(CT) and preeclampsia was examined longitudinally among 205 cases and 423 normotensive controls nested within the Collaborative Perinatal Project. Antibodies were analyzed at a first prenatal visit (mean 14.2 weeks) and at delivery. Prenatal infections were identified as IgG/IgM seroconversion or a four-fold rise in IgG antibody titers. Although serological evidence of incident prenatal CT infection was uncommon (n=9, 1.4%) in this general pregnant population, infected women were more likely to develop preeclampsia, after adjustment for maternal age, body mass index, smoking status, race and time between blood draws (ORadj7.2, 95% CI 1.3 - 39.7).
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA ; Magee-Womens Research Institute, Pittsburgh, PA.
Catherine L
CL
Haggerty
Mark A
MA
Klebanoff
Inge
I
Panum
Soren A
SA
Uldum
Debra C
DC
Bass
Jorn
J
Olsen
James M
JM
Roberts
Roberta B
RB
Ness
Chlamydia pneumoniae; Chlamydia trachomatis; cytomegalovirus; herpes simplex virus; preeclampsia