Dragon's blood dropping pills have protective effects on focal cerebral ischemia rats model.
Dragon's blood is a bright red resin obtained from Dracaena cochinchinensis (Lour.) S.C.Chen (Yunnan, China). As a traditional Chinese medicinal herb, it has great traditional medicinal value and is used for wound healing and to stop bleeding. Its main biological activity comes from phenolic compounds. In this study, phenolic compounds were made into dropping pills and their protective effects were examined by establishing focal cerebral ischemia rats model used method of Middle Cerebral Artery Occlusion (MCAO), and by investigating indexes of neurological scores, infarct volume, cerebral index, cerebral water content and oxidation stress. Compared to model group, high, middle and low groups of Dragon's blood dropping pills could improve the neurological function significantly (p<0.01) and reduce cerebral infarct volume of focal cerebral ischemia rats remarkably (p<0.05-0.01). Meanwhile, each group could alleviate cerebral water content and cerebral index (p<0.05-0.01) and regulate oxidative stress of focal cerebral ischemia rats obviously (p<0.05-0.01). Activities of middle group corresponded with that treated with positive control drug. The results obtained here showed that Dragon's blood dropping pills had protective effects on focal cerebral ischemia rats.
School of Life Science, Beijing Institute of Technology, Beijing 100081, PR China.
Nian
N
Xin
Fang-Ju
FJ
Yang
Yan
Y
Li
Yu-Juan
YJ
Li
Rong-Ji
RJ
Dai
Wei-Wei
WW
Meng
Yan
Y
Chen
Yu-Lin
YL
Deng
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002544:Cerebral Infarction / Q000209:etiology / Q000517:prevention & control; D004195:Disease Models, Animal; D031409:Dracaena / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012116:Resins, Plant / Q000494:pharmacology / Q000627:therapeutic use; D014867:Water / Q000378:metabolism
D000975:Antioxidants; D018696:Neuroprotective Agents; D010636:Phenols; D010936:Plant Extracts; D012116:Resins, Plant; D014867:Water; D008315:Malondialdehyde; C525191:dragon's blood
2,3,5-triphenyltetrazolium chloride; ATP; CAT; CCA; Cerebral index; Cerebral water content; Dragon's blood dropping pills; ECA; Focal cerebral ischemia; GSH-PX; ICA; ICVD; Infarct volume; MCAO; MDA; Middle Cerebral Artery Occlusion; Middle Cerebral Artery Occlusion (MCAO); NO; NOS; Neurological deficit scores; Oxidation stress; SOD; TTC; V; adenosine triphosphate; catalase; cerebral infarction volume; common carotid artery; external carotid artery; glutathione peroxidase; internal carotid artery; ischemic cerebrovascular disease; malondialdehyde; nitric oxide; nitric oxide synthase; superoxide dismutase