Coronary artery diseases in Japanese patients with nonvalvular atrial fibrillation.
BACKGROUND
Both the prevalence of atrial fibrillation and coronary artery disease (CAD) is increasing in aged societies. However, limited data are available regarding the prevalence of CAD and the incidence of coronary events in Japanese patients with nonvalvular atrial fibrillation (NVAF).


RESULTS
The data in this study were derived from Shinken Database 2004-2010, which includes 15,227 new patient visitors to the Cardiovascular Institute between June 2004 and March 2011. In the database, 1835 patients were diagnosed with NVAF (mean age 63 years, mean CHADS2 score 1.1 ± 1.1, and 75% were men). The prevalence of CAD at the initial visit was 118 patients (6.4%). They were older age and had a greater prevalence of men, more history of congestive heart failure and more history of cardiovascular risk factors rather than those without. During the follow-up period of 532 ± 599 days, coronary events (myocardial infarction, unstable angina, and stable angina) occurred in 51 patients (1.9%/year). Multivariate analysis showed that a history of CAD (p<0.001) and older age (p=0.024) were independent predictors of the incidence of future coronary events.


CONCLUSIONS
In Japanese patients with NVAF, both the presence of CAD and the occurrence of coronary events are not uncommon. History of CAD and older age are strongly associated with the incidence of coronary events.
The Cardiovascular Institute, Tokyo, Japan. Electronic address: swcqg251@yahoo.co.jp.
Keitaro
K
Senoo
The Cardiovascular Institute, Tokyo, Japan.
Shinya
S
Suzuki
The Cardiovascular Institute, Tokyo, Japan.
Koichi
K
Sagara
The Cardiovascular Institute, Tokyo, Japan.
Takayuki
T
Otsuka
The Cardiovascular Institute, Tokyo, Japan.
Shunsuke
S
Matsuno
The Cardiovascular Institute, Tokyo, Japan.
Tokuhisa
T
Uejima
The Cardiovascular Institute, Tokyo, Japan.
Yuji
Y
Oikawa
The Cardiovascular Institute, Tokyo, Japan.
Junji
J
Yajima
The Cardiovascular Institute, Tokyo, Japan.
Kazuyuki
K
Nagashima
The Cardiovascular Institute, Tokyo, Japan.
Hajime
H
Kirigaya
The Cardiovascular Institute, Tokyo, Japan.
Hitoshi
H
Sawada
The Cardiovascular Institute, Tokyo, Japan.
Tadanori
T
Aizawa
University of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, United Kingdom.
Gregory Y H
GY
Lip
The Cardiovascular Institute, Tokyo, Japan.
Takeshi
T
Yamashita
D000367:Age Factors; D000368:Aged; D060050:Angina, Stable / Q000453:epidemiology / Q000209:etiology; D000789:Angina, Unstable / Q000453:epidemiology / Q000209:etiology; D044466:Asian People; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012737:Sex Factors; D013997:Time Factors
Coronary artery disease; Incidence; Nonvalvular atrial fibrillation; Prognosis