Long-term use of flupirtine leads to withdrawal symptoms and is associated with dependency.
This is the case of a 44-year-old woman, who was treated as an inpatient because of withdrawal symptoms like sweating, tremors, sleeping disorders and irritability after long-term use of flupirtine. She recovered by symptom-based application of pipamperone within 72 h after flupirtine cessation.
Department of Psychiatry and Psychotherapy, University of -Erlangen, Erlangen, Germany.
J
J
Wielopolski
K
K
Reich
M
M
Clepce
J
J
Kornhuber
N
N
Thuerauf
D000328:Adult; D000631:Aminopyridines / Q000009:adverse effects*; D000700:Analgesics / Q000009:adverse effects*; D002090:Butyrophenones / Q000627:therapeutic use; D005260:Female; D006801:Humans; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000150:complications* / Q000188:drug therapy
D000631:Aminopyridines; D000700:Analgesics; D002090:Butyrophenones; C005569:pipamperone; C034161:flupirtine