Successful use of dydrogesterone as maintenance therapy in recurrent endometrial stromal sarcoma: a case report.
Endometrial stromal sarcoma is known to be a hormone-dependent tumor. Efficacy of hormonal therapy including high-dose progestins, aromatase inhibitors or gonadotropin-releasing hormone analogs has been reported. We report a case of recurrent endometrial stromal sarcoma, the tumor cells of which were strongly positive for CD10, estrogen and progesterone receptors. Although almost all of the pelvic tumors infiltrating the rectum or pelvic side wall remained, the patient is alive with slight disease 9 years and 6 months after the initial failure. During the treatment period of 4 years and 3 months, the patient was treated exclusively with dydrogesterone at a daily dose of 10 mg and the tumor clinically disappeared. Dydrogesterone at a daily dose of 10 mg may be effective in treating low-grade endometrial stromal sarcoma.
*Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, 4-2, Kikusui, Shiroishi-Ku, Sapporo 003-0804, Japan. yukiharu@sap-cc.go.jp.
Daisuke
D
Akashi
Yukiharu
Y
Todo
Chisa
C
Shimada
Kazuhira
K
Okamoto
Shinichiro
S
Minobe
Hidenori
H
Kato
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004394:Dydrogesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy; D011372:Progestins / Q000008:administration & dosage / Q000627:therapeutic use*; D011788:Quality of Life; D018203:Sarcoma, Endometrial Stromal / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D011372:Progestins; D004394:Dydrogesterone; D017258:Medroxyprogesterone Acetate
dydrogesterone; endometrial stromal sarcoma; hormonal therapy