Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis.
OBJECTIVE
This study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE).


METHODS
A meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1RN) polymorphisms and SLE.


RESULTS
A total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A -889 T allele in the overall population and Europeans (OR = 0.858, 95% CI = 0.737-0.986, p = 0.032; OR = 0.827, 95% CI = 0.687-0.994, p = 0.043). Meta-analysis of the IL1RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN*2 = 1.539, 95% CI = 1.266-1.871, p = 1.5 × 10(-2)) and in Europeans and Asians (OR = 1.483, 95% CI = 1.187-1.852, p = 0.001; OR = 1.787, 95% CI = 1.167-2.736, p=0.008). No associations were found between SLE and the IL1B -511 C/T, 3953 C/T, and IL1A +4845 G/T polymorphisms.


CONCLUSIONS
This meta-analysis suggests IL1A -889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1RN*2 allele is associated with susceptibility to SLE in Europeans and Asians.
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Gwan Gyu
GG
Song
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Jae-Hoon
JH
Kim
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Young Ho
YH
Seo
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Sung Jae
SJ
Choi
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Jong Dae
JD
Ji
Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea. Electronic address: lyhcgh@korea.ac.kr.
Young Ho
YH
Lee
D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias
D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta