Why should we care about fly tumors?: The case of JAK-STAT and EGFR cooperation in oncogenesis.
Drosophila is proving to be a valuable model for studying aggressive tumors induced by the combined activation of EGFR and JAK-STAT signaling. Here we summarize some of the most recent data showing that tissue damage and the modulation of common pathway regulators are at the heart tumor progression and metastasis.
CABD (CSIC/JA/UPO); Universidad Pablo de Olavide; Seville, Spain.
James Castelli-Gair
JC
Hombría
Florenci
F
Serras
EGFR; JAK-STAT; SOCS36; SOCS5; bantam; cell competition; tumor