Intermittent single-agent doxorubicin for the treatment of canine B-cell lymphoma.
Canine B-cell lymphoma is a highly treatable disease, but cost and logistical factors may hamper an owner's ability to pursue treatment of their pet with this disease. The authors evaluated the use of single-agent doxorubicin in an intermittent fashion for efficacy in the treatment of this disease. Morphologic and clinical data were analyzed for prognostic significance. Eighteen dogs with B-cell lymphoma, all with multicentric disease, were enrolled. The overall complete response (CR) rate was 78%, median total doxorubicin remission time (TDR) was 80.5 days, and median overall survival (OS) was 169.5 days. The median number of doxorubicin doses administered was 4.5. First remission times were significantly affected by clinical stage and substage of disease. Outcome for the dogs in this study were similar to those previously reported for single-agent doxorubicin treatment. Additionally, the intermittent nature of the treatments made the described protocol more feasible for the owners who enrolled their pets in this study. Intermittent single-agent doxorubicin is not a substitute for multiagent chemotherapy protocols in the treatment of canine lymphoma; however, it is a reasonable alternative if the cost and time commitments are limiting factors for an owner.
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS; and Boren Veterinary Medical Teaching Hospital, Stillwater, OK (K.R.).
Mary Lynn
ML
Higginbotham
Dudley L
DL
McCaw
James K
JK
Roush
Jerome C
JC
Nietfeld
Melinda J
MJ
Wilkerson
Kimberly
K
Reeds
Diana
D
Burr
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage*; D004334:Drug Administration Schedule / Q000662:veterinary; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000662:veterinary*; D009367:Neoplasm Staging / Q000662:veterinary; D012074:Remission Induction; D016019:Survival Analysis; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin