Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.
Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230-1439, USA; Department of Pathology, National University Hospital, 119074, Singapore.
Shi
S
Wang
Alexander
A
Tzankov
Zijun Y
ZY
Xu-Monette
Sylvia
S
Hoeller
Sa A
SA
Wang
Kristy L
KL
Richards
Shanxiang
S
Zhang
Jonathan W
JW
Said
L Jeffrey
LJ
Medeiros
Ken H
KH
Young
D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D058617:Composite Lymphoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D020522:Lymphoma, Mantle-Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male
D015703:Antigens, CD; D007143:Immunoglobulin Heavy Chains; D019938:Cyclin D1
Clonal relationship; Composite lymphoma; FISH; Follicular lymphoma; IgH; Mantle cell lymphoma; RLP