[Efficiency of postoperative ovulation induction on infertile women with minimal-mild endometriosis].
OBJECTIVE
To investigate the efficacy of timely ovulation induction on Infertility women with minimal-mild endometriosis (EMS) after laparoscopy combined with hysteroscopy.


METHODS
A randomized controlled trial was performed on 132 infertility women diagnosed with minimal-mild EMS according to r-AFS by laparoscopy. They were divided into two groups after operations. The experimental group (n = 68) was administrated timely ovulation induction with clomiphene citrate tablets at the first menstrual cycle post-operation and given conceive guidance. The control group (n = 64) was treated with expectant treatment only. All the patients were followed up for 18 months after the surgery. Pregnancy rates and pregnancy outcomes within 1 year post-operation were compared between the two groups.


RESULTS
During the follow up period, there were 6 cases lost. At 3 months after surgery, pregnancy rates (PR) in the experimental group and the control group were 37.88%, 21.67% respectively; the PR at 4-6 months were 29.27%, 19.15% in the two groups respectively. The less-than-6-months PR in the experimental group (56.06%) was significantly higher than that of the control group (36.67%) (P < 0.05), and also higher than the PR of 7-12 months post-operation in the same group (P < 0.05). Significant difference was found for the abortion rate between the ovulation induction group (12.19%) and the control group (26.92%) (P < 0.05).


CONCLUSIONS
Timely ovulation induction after laparoscopic surgery combined with hysteroscopy could significantly increase pregnancy rate and reduce abortion rate in infertility patients with minimal-mild endometriosis.
Department of Reproductive Endocrinology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Jin
J
Gong
Li
L
Chen
Dan
D
Zhang
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D004715:Endometriosis / Q000150:complications* / Q000601:surgery*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D010535:Laparoscopy; D010062:Ovulation Induction / Q000379:methods; D011184:Postoperative Period; D011247:Pregnancy; D018873:Pregnancy Rate; D055815:Young Adult
D002996:Clomiphene