Systemic side effects of antiviral therapy in a patient with acute retinal necrosis.
OBJECTIVE
To report a case of Acute Retinal Necrosis (ARN)-developed nephrotoxicity during intravenous acyclovir treatment and toxic hepatitis during oral valacyclovir treatment.


METHODS
Interventional case report.


METHODS
Retrospective chart review.


RESULTS
A 45-year-old male with ARN treated with intravenous acyclovir developed nephrotoxicity. After switching to oral valacyclovir, toxic hepatitis developed. Both renal and liver function tests returned to normal levels after drug cessation


CONCLUSIONS
Although rare, clinicians should be aware of the potential nephrotoxic and hepatotoxic side effects of antiviral therapy during ARN treatment.
Department of Ophthalmology, Umraniye Training and Research Hospital , Istanbul , Turkey and.
Esra
E
Guney
Betul Ilkay Sezgin
BI
Akcay
Gurkan
G
Erdogan
Cıhan
C
Unlu
Kansu
K
Bozkurt
Umut
U
Onur
D000212:Acyclovir / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D015828:Eye Infections, Viral / Q000150:complications / Q000188:drug therapy*; D006563:Herpes Zoster Ophthalmicus / Q000150:complications / Q000188:drug therapy*; D014645:Herpesvirus 3, Human / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000209:etiology; D000077483:Valacyclovir; D014633:Valine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000998:Antiviral Agents; D004279:DNA, Viral; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir
Acute retinal necrosis; acyclovir; herpes virus; side effects; valacyclovir