Frequent triple-hit expression of MYC, BCL2, and BCL6 in primary lymphoma of the central nervous system and absence of a favorable MYC(low)BCL2 (low) subgroup may underlie the inferior prognosis as compared to systemic diffuse large B cell lymphomas.
Department of Neuropathology, University Hospital of Cologne, Kerpener Str. 62, 50924, Cologne, Germany.
Anna
A
Brunn
Inga
I
Nagel
Manuel
M
Montesinos-Rongen
Wolfram
W
Klapper
Inga
I
Vater
Werner
W
Paulus
Volkmar
V
Hans
Ingmar
I
Blümcke
Joachim
J
Weis
Reiner
R
Siebert
Martina
M
Deckert
D014408:Biomarkers, Tumor; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D019254:Genes, bcl-2 / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics*
D014408:Biomarkers, Tumor; D051560:Proto-Oncogene Proteins c-bcl-6