[Optimized treatment program for unstable angina by integrative medicine based on partially observable Markov decision process].
OBJECTIVE
To initially optimize comprehensive treatment program for treating and preventing unstable angina (UA) by integrative medicine (IM).


METHODS
Based on partially observable Markov decision process model (POMDP), we chose 3 syndrome elements, i.e., qi deficiency, blood stasis, and phlegm turbidity from UA inpatients. The efficacy of treating UA by IM was objectively assessed by in-depth data mining and analyses.


RESULTS
The treatment programs for UA patients of qi deficiency syndrome, blood stasis syndrome, and phlegm turbidity syndrome were recommended as follows: nitrates +statins +clopidogrel +angiotensin II receptor blockers +heparins +Astragalus membranaceus +Condonopsis + poria and large-head atractylodes rhizome (ADR = 0.85077869); nitrates + aspirin + clopidogrel + statins + heparins + Astragalus membranaceus + safflower + peach seed + red peony root (ADR = 0.70773000); nitrates + aspirin + statins + angiotensin-converting inhibitors + snakegourd fruit + onion bulb + ternate pinellia + tangerine peel (ADR = 0.72509600).


CONCLUSIONS
As a POMDP based optimized treatment programs for UA, it can be used as a reference for further standardization and formulation of UA program by integrative medicine.
Department of General Practice, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Yan
Y
Feng
Hao
H
Xu
Kai
K
Liu
Xue-Zhong
XZ
Zhou
Ke-Ji
KJ
Chen
D000789:Angina, Unstable / Q000628:therapy*; D003657:Decision Making; D020000:Decision Support Systems, Clinical; D006801:Humans; D055048:Integrative Medicine; D008390:Markov Chains