Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus.
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer's disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer's disease and the approaches that make IDE a potential target, are discussed.
Rizwanul
R
Haque
Laboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIRCentral Drug Research Institute, Lucknow, 226 001, UP, India. anazir@cdri.res.in.
Aamir
A
Nazir
D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D007339:Insulysin / Q000235:genetics / Q000378:metabolism*
D007339:Insulysin