Management of cosmetic embarrassment caused by Malassezia spp. with fruticose lichen Cladia using phylogenetic approach.
During anti-Malassezia screening of plants by CLSI broth microdilution method, Cladia aggregata (Swartz) Nyl. (family Cladoniaceae), a fruticose lichen from Sikkim (northeast Himalayan region), has been found effective at minimum inhibitory concentrations (mg/mL) of 2.72, 0.63, and 1.28 against yeast-like fungi namely, M. furfur, M. globosa and M. sympodialis, respectively. These test pathogens are responsible for pityriasis versicolor (PV) and seborrheic dermatitis (SD) in humans. We tried to establish the reason for variable MICs against various Malassezia spp. using bioinformatical tools, thereby reducing the cost of the experimentation. This is the first report on anti-Malassezia activity of C. aggregata and thus can serve as a potential source for the development of cosmaceuticals.
Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad 211002, India.
Anand
A
Pandey
Rohit K
RK
Mishra
Amit K
AK
Tiwari
Awadhesh
A
Kumar
A K
AK
Bajaj
Anupam
A
Dikshit
D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism; D002687:Chitin Synthase / Q000737:chemistry; D003358:Cosmetics / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D008011:Lichens / Q000737:chemistry / Q000502:physiology*; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010802:Phylogeny
D000935:Antifungal Agents; D003358:Cosmetics; D015725:Fluconazole; D002687:Chitin Synthase