Approaching untargetable tumor-associated antigens with antibodies.
Approved therapeutic antineoplastic antibodies have targeted extracellular or cell-surface molecules. ESK1 is the first fully human T-cell receptor-like antibody targeting an intracellular tumor-associated antigen, Wilm's tumor 1 (WT1). In murine xenograft models, ESK1 exhibits a high specificity and exert robust antineoplastic effects against human cancers that express WT1 epitopes on HLA-A201 molecules.
Memorial Sloan-Kettering Cancer Center; New York, NY USA.
Tao
T
Dao
Cheng
C
Liu
David A
DA
Scheinberg
MHC; TCR-like; WT1; cancer; monoclonal antibodies