Bone quality around bioactive silica-based coated stainless steel implants: analysis by micro-Raman, XRF and XAS techniques.
Surface modification of surgical stainless steel implants by sol gel coatings has been proposed as a tool to generate a surface that besides being protective could also create a "bioactive" interface to generate a natural bonding between the metal surface and the existing bone. The aim of this work is to analyze the quality and bone formation around hybrid bioactive coatings containing glass-ceramic particles, made by sol-gel process on 316L stainless steel used as permanent implant in terms of mineralization, calcium content and bone maturity with micro Raman, X-ray microfluorescence and X-ray absorption techniques. Uncoated implants seem to generate a thin bone layer at the beginning of osseointegration process and then this layer being separated from the surface with time. The hybrid coatings without glass-ceramic particles generate new bone around implants, with high concentration of Ca and P at the implant/tissue interface. This fact seems to be related with the presence of silica nanoparticles in the layer. The addition of bioactive particles promotes and enhances the bone quality with a homogeneous Ca and P content and a low rate of beta carbonate substitution and crystallinity, similar to young and mechanical resistant bone.
INTEMA, Universidad Nacional del Mar del Plata-CONICET, Juan B. Justo 4302, B7608FDQ Mar del Plata, Argentina. Electronic address: jballarre@fi.mdp.edu.ar.
Josefina
J
Ballarre
Paula M
PM
Desimone
Matthieu
M
Chorro
Matías
M
Baca
Juan Carlos
JC
Orellano
Silvia M
SM
Ceré
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003102:Colloids; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration; D044367:Phase Transition; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013059:Spectrum Analysis, Raman; D013193:Stainless Steel / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties; D056928:X-Ray Absorption Spectroscopy
D020099:Coated Materials, Biocompatible; D003102:Colloids; D010710:Phosphates; D013193:Stainless Steel; D012822:Silicon Dioxide; D002118:Calcium
Coatings; Newly-formed bone; Raman; Surgical grade stainless steel; Synchrotron radiation