Gut-targeted immunonutrition boosting natural killer cell activity using Saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects.
The aim of this study was to assess the immunomodulatory effect of KC-1317 (a symbiotic mixture containing Saccharomyces boulardii lysate in a cranberry, colostrum-derived lactoferrin, fragaria, and lactose mixture) supplementation in immune-compromised but otherwise healthy elderly subjects. A liquid formulation of KC-1317 was administered in a randomized controlled trial (RCT) fashion to healthy volunteers (65-79 years) previously selected for low natural killer (NK) cell activity, and this parameter was checked at the completion of the study. A significant improvement in NK cell activity of KC-1317 consumers was observed as compared to placebo at the end of 2 months. Although preliminary, these beneficial immune-modulatory effects of KC-1317 in aged individuals might indicate its employment within a wider age-management strategy.
1 Integrative Immunology Research Center and Clinic , Nagoya, Japan .
Yasuhiro
Y
Naito
Francesco
F
Marotta
Makoto K
MK
Kantah
Nicola
N
Zerbinati
Almagul
A
Kushugulova
Zhaxybay
Z
Zhumadilov
Nicola
N
Illuzzi
Chiara
C
Sapienza
Hiroshi
H
Takadanohara
Riyichi
R
Kobayashi
Roberto
R
Catanzaro
D000368:Aged; D000375:Aging / Q000187:drug effects / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000276:immunology*; D006262:Health; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D012440:Saccharomyces / Q000737:chemistry*
D007155:Immunologic Factors