Mechanisms of adverse cardiometabolic consequences of obesity.
Obesity is an epidemic that threatens the health of millions of people worldwide and is a major risk factor for cardiovascular diseases, hypertension, diabetes, and dyslipidemia. There are multiple and complex mechanisms to explain how obesity can cause cardiovascular disease. In recent years, studies have shown some limitations in the way we currently define obesity and assess adiposity. This review focuses on the mechanisms involved in the cardiometabolic consequences of obesity and on the relationship between obesity and cardiovascular comorbidities, and provides a brief review of the latest studies focused on normal weight obesity and the obesity paradox.
Division of Cardiovascular Disease, and Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, diaz.carlos@mayo.edu.
Carlos M
CM
Diaz-Melean
Virend K
VK
Somers
Juan Pablo
JP
Rodriguez-Escudero
Prachi
P
Singh
Ondrej
O
Sochor
Ernesto Manuel
EM
Llano
Francisco
F
Lopez-Jimenez
D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism; D012307:Risk Factors