Prion chemical biology: on the road to therapeutics?
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.
Dainton Building, Department of Chemistry, University of Sheffield, Brookhill, Sheffield S3 7HF, UK. b.chen@sheffield.ac.uk.
Beining
B
Chen
Mark
M
Thompson
Jennifer
J
Louth
Kai
K
Guo
D000818:Animals; D055808:Drug Discovery; D006801:Humans; D017096:Prion Diseases / Q000188:drug therapy* / Q000378:metabolism; D011328:Prions / Q000037:antagonists & inhibitors* / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D011328:Prions; D054852:Small Molecule Libraries