Immunohistochemical expression of RBP2 and LSD1 in papillary thyroid carcinoma.
OBJECTIVE
To investigate the prognostic significance of LSD1 and RBP2 expression in patients with papillary thyroid carcinoma.


METHODS
LSD1 and RBP2 expressions were detected by immunohistochemistry in surgically resected samples from thyroid adenoma, papillary thyroid carcinoma and paracancerous tissues.


RESULTS
To be members of histone demethylases, LSD1 and RBP2 were both localized mainly to the thyroid cell nucleus. Despite the fact that both RBP2 and LSD1 expressions were higher in papillary thyroid carcinoma than in paracancerous tissues (U=-3.855, p=0.000; U=-5.575, p=0.000) and thyroid adenoma (U=-1.972, p=0.049; U=-3.190, p=0.001), they did not show us statistical correlation (r=-0.149, p=0.270). Like LSD1 (U=-2.286, p=0.022), RBP2 expression was less frequently in paracancerous tissues than in thyroid adenoma (U=-1.985, p=0.047). Neither LSD1 nor RBP2 expression was significantly associated with age, gender, stage status, tumor size, and lymph node metastases (p>0.05).


CONCLUSIONS
Both LSD1 and RBP2 are well related with the occurrence and malignant transformation of papillary thyroid carcinoma. Though the positive expression of both LSD1 and RBP2 can be used to estimate the potentiality of thyroid carcinoma and help for the adjuvant treatment, LSD1 is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.
Department of Pathology, Basic Science School, Jining Medical University, Jining, Shandong, China; Kong001199@yahoo.com, cuiwenmd@163.com.
Lingling
L
Kong
Guoan
G
Zhang
Xu
X
Wang
Jian
J
Zhou
Sen
S
Hou
Wen
W
Cui
D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary; D005260:Female; D056466:Histone Demethylases / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D054840:Retinol-Binding Proteins, Cellular / Q000096:biosynthesis*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; C518459:RBP2 protein, human; D054840:Retinol-Binding Proteins, Cellular; D056466:Histone Demethylases; C495195:KDM1A protein, human