The hidden phenomenon of oxidative stress during treatment of subclinical-mild hypothyroidism: a protective nutraceutical intervention.
Recent studies suggest that subjects with hypothyroidism under therapy with levothyroxine (L-T4) might develop oxidative stress. The aim of this study was to test a redox-balance modulator, fermented papaya-based nutraceutical (FPP), together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. A total of 60 females treated for SH-MH were divided into two matched groups and received either FPP 3 grams 1 sachet three times a day (t.i.d.) or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH (p<0.05 vs. control) and even more under T4 treatment (p<0.05). FPP caused a normalization of redox markers (p<0.01 vs. placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress, whereas a redox-modulator therapy is advisable, given the long-lasting treatment in such cases.
1 ReGenera Research Group for Aging Intervention , Milan, Italy .
Claudio
C
Tomella
Roberto
R
Catanzaro
Nicola
N
Illuzzi
Anna
A
Cabeca
Nicola
N
Zerbinati
Gulcin
G
Celep
Michele
M
Milazzo
Chiara
C
Sapienza
Angelo
A
Italia
Aldo
A
Lorenzetti
Francesco
F
Marotta
D000293:Adolescent; D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000473:pathology*; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D055815:Young Adult
D020011:Protective Agents