Ultraviolet (UVB and UVA) photoprotector activity and percutaneous penetration of extracts obtained from Arrabidaea chica.
The aim of this work is to investigate the photoprotection activity and toxicity level of formulations containing the extract and its fractions obtained from leaves of Arrabidaea chica. The ex vivo percutaneous penetration of the extract was evaluated using the photoacoustic spectroscopy technique. The formulation presented optical absorption in the ultraviolet region, including UVA and UVB. This formulation was obtained without adding inorganic UV filters, as is frequently used in commercial sunscreens. The results showed a penetration rate similar to those of commercial sunscreens with its presence on the skin surface at least 180 min after the application. This formulation presented no toxic effects evaluated using hematological, biochemical, and histological assays. The results suggest that the formulation from the leaves of A. chica provides substantial protection against UVA + UVB radiation with a possible advantage of being natural and free of inorganic compounds compared with the majority of available commercial sunscreens.
Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo, 5790, 87020-900 Maringá, PR, Brazil.
Jackeline T G
JT
Siraichi
Franciana
F
Pedrochi
Maria R M
MR
Natali
Tânia
T
Ueda-Nakamura
Benedito P Dias
BP
Filho
Antonio C
AC
Bento
Mauro L
ML
Baesso
Celso V
CV
Nakamura
D000704:Analysis of Variance; D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects; D008297:Male; D061088:Photoacoustic Techniques; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D012869:Skin Absorption / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays
D010936:Plant Extracts; D013473:Sunscreening Agents