Perioperative and clinical outcomes in the management of epithelial ovarian cancer using a robotic or abdominal approach.
OBJECTIVE
To evaluate the feasibility and efficacy of robotic-assisted management of epithelial ovarian cancer.


METHODS
Retrospective review of robotic-assisted or abdominal ovarian cancer cases presenting with pelvic mass, initial staging, or debulking after neoadjuvant chemotherapy performed by a single surgeon (2008-2012). Patient characteristics and outcomes were compared using chi-squared or Student's t-tests.


RESULTS
There were 63 robotic and 26 abdominal cases. Patient characteristics were similar for age, uterine weight, and BMI, with prior abdominal surgery more common in the abdominal group (p=0.0257). Robotic operative time was longer (p<0.0001), while blood loss (p<0.0001) and hospital stay (p=0.0009) were reduced. Major complication rates (16% vs. 23%, p=0.4209) and lymphadenectomy yields (13 vs. 11 nodes, p=0.2310) were similar. Neoadjuvant chemotherapy was more common in the robotic group (52% vs. 15%, p=0.0013). Residual disease rates for all cases (73% vs. 50%, p=0.880) and for Stage II-IV cases (61% vs. 40%, p=0.929) were equivalent. Follow-up was longer for the abdominal group; however, an equivalent percentage of patients had at least 1 year of follow-up (57% vs. 77%, p=0.0789). At 1 year, survival and no evidence of disease (NED) rates were equivalent for all cases (survival: 97% vs. 90%, p=0.2501; NED: 81% vs. 85%, p=0.6773) and for Stage II-IV cases (survival: 96% vs. 88%, p=0.3080; NED: 76% vs. 81%, p=0.6920).


CONCLUSIONS
A robotic approach for the management of epithelial ovarian cancer, including patients treated with neoadjuvant chemotherapy, is feasible and effective. Debulking, recurrence, and survival rates were similar to laparotomy at 1 year.
Northside Hospital, 980 Johnson Ferry Road, Suite 1080, Atlanta, GA 30342, USA. Electronic address: gfeuer@aol.com.
Gerald A
GA
Feuer
Nisha
N
Lakhi
James
J
Barker
Stephen
S
Salmieri
Mathew
M
Burrell
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D000077216:Carcinoma, Ovarian Epithelial; D017024:Chemotherapy, Adjuvant; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D012371:Robotics / Q000379:methods*; D016896:Treatment Outcome
D016190:Carboplatin; D017239:Paclitaxel
Advanced ovarian cancer; Debulking; Minimally invasive surgery; Robotic surgery