Postdate pregnancy: changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity.
11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate women who had spontaneous delivery or after induction the non-responders showed significantly low c and high 11β-HSD2 expression and activity These data suggest that disrupted expression and activity of 11β-HSDs may occur in some postdate pregnancies.
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
R
R
Novembri
C
C
Voltolini
M
M
Torricelli
F M
FM
Severi
P
P
Marcolongo
A
A
Benedetti
J R
JR
Challis
F
F
Petraglia
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000235:genetics / Q000378:metabolism*; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D036861:Delivery, Obstetric; D015232:Dinoprostone; D015536:Down-Regulation / Q000187:drug effects; D004351:Drug Resistance; D005321:Extraembryonic Membranes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D006801:Humans; D007751:Labor, Induced; D010120:Oxytocics; D010920:Placenta / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011273:Pregnancy, Prolonged / Q000201:enzymology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D015203:Reproducibility of Results; D015854:Up-Regulation / Q000187:drug effects
D010120:Oxytocics; D012333:RNA, Messenger; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2; C468386:HSD11B1 protein, human; C468387:HSD11B2 protein, human; D015232:Dinoprostone
11Beta-HSD enzymes; Labor induction; Postdate