Autophagy meets phagocytosis.
Autophagy can degrade intracellular bacteria, but how this pathway contributes to phagocytosis is unclear. In this issue of Immunity, Bonilla et al. (2013) demonstrate an additional role for autophagy in Mycobacterium tuberculosis internalization by macrophages.
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: ken.cadwell@med.nyu.edu.
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D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy / Q000276:immunology*; D000071193:Autophagy-Related Protein 7; D006360:Heat-Shock Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D010587:Phagocytosis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000096:biosynthesis*; D051117:Scavenger Receptors, Class A / Q000096:biosynthesis*; D000071456:Sequestosome-1 Protein
D048868:Adaptor Proteins, Signal Transducing; C502661:Atg7 protein, mouse; D006360:Heat-Shock Proteins; C092228:Marco protein, mouse; D008869:Microtubule-Associated Proteins; C495140:Msr1 protein, mouse; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse; D011971:Receptors, Immunologic; D051117:Scavenger Receptors, Class A; D000071456:Sequestosome-1 Protein; C101343:Sqstm1 protein, mouse; D000071193:Autophagy-Related Protein 7