Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease.
Management of pediatric chronic liver disease is limited by lack of validated noninvasive biomarkers of histologic severity. We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children.
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address: stavra.xanthakos@cchmc.org.
Stavra A
SA
Xanthakos
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Daniel J
DJ
Podberesky
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Suraj D
SD
Serai
Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Lili
L
Miles
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Eileen C
EC
King
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
William F
WF
Balistreri
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Rohit
R
Kohli
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D054459:Elasticity Imaging Techniques / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
ARFI; AUROC; Acoustic radiation force imaging; Area under the receiver operating characteristic curve; BMI; Body mass index; MRE; Magnetic resonance elastography; NAFLD; NASH; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; ROI; Region of interest; TE; Transient elastography; US; Ultrasound