Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients. We found that Asian patients had fewer canonical oncogenic mutations in the genes tested (60% vs Black 79% (P = 0.011) and White 77% (P = 0.015)), and that BRAF mutations occurred at a higher frequency in White patients (17% vs Asian 4% (P = 0.004) and Black 7% (P = 0.014)). These results suggest that the use of genomic approaches to elucidate the different ancestral determinants harbored by patient populations may help to more precisely and effectively treat colorectal cancer.
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; The Broad Institute, Cambridge, Massachusetts, United States of America.
Megan C
MC
Hanna
Christina
C
Go
Christine
C
Roden
Robert T
RT
Jones
Panisa
P
Pochanard
Ahmed Yasir
AY
Javed
Awais
A
Javed
Chandrani
C
Mondal
Emanuele
E
Palescandolo
Paul
P
Van Hummelen
Charles
C
Hatton
Adam J
AJ
Bass
Sung Min
SM
Chun
Deuk Chae
DC
Na
Tae-Im
TI
Kim
Se Jin
SJ
Jang
Raymond U
RU
Osarogiagbon
William C
WC
Hahn
Matthew
M
Meyerson
Levi A
LA
Garraway
Laura E
LE
MacConaill
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D044383:Black People; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D059645:Mutation Rate; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D044465:White People; D055815:Young Adult
D048493:Proto-Oncogene Proteins B-raf