Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body.
The medial nucleus of the trapezoid body (MNTB) in the superior olivary complex (SOC) is an inhibitory hub considered critical for binaural sound localization. We show that genetic ablation of MNTB neurons in mice only subtly affects this ability by prolonging the minimum time required to detect shifts in sound location. Furthermore, glycinergic innervation of the SOC is maintained without an MNTB, consistent with the existence of parallel inhibitory inputs. These findings redefine the role of MNTB in sound localization and suggest that the inhibitory network is more complex than previously thought.
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106, Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom, Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14642, and Richard King Mellon Institute for Pediatric Research, Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Walid
W
Jalabi
Cornelia
C
Kopp-Scheinpflug
Paul D
PD
Allen
Emanuele
E
Schiavon
Rita R
RR
DiGiacomo
Ian D
ID
Forsythe
Stephen M
SM
Maricich
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000161:Acoustic Stimulation; D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000502:physiology; D051767:Early Growth Response Protein 2 / Q000235:genetics; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000235:genetics; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007839:Functional Laterality; D005998:Glycine / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009847:Olivary Nucleus / Q000166:cytology* / Q000502:physiology*; D018408:Patch-Clamp Techniques; D013017:Sound Localization / Q000187:drug effects / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D051767:Early Growth Response Protein 2; C497327:Egr2 protein, mouse; C080330:En1 protein, mouse; D018691:Excitatory Amino Acid Antagonists; D050487:Glycine Plasma Membrane Transport Proteins; D018398:Homeodomain Proteins; C493270:Slc6a5 protein, mouse; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; C056639:2-amino-5-phosphopentanoic acid; D013331:Strychnine; D014633:Valine; D005998:Glycine