Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.
Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
Zhifang
Z
Xi
Wei
W
Bie
Wei
W
Chen
Dong
D
Liu
Leen
L
van Ofwegen
Peter
P
Proksch
Wenhan
W
Lin
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans
D004224:Diterpenes; C037071:cembrane