Interaction between paliperidone and carbamazepine.
BACKGROUND
This aim of this study was to determine the impact of carbamazepine on the pharmacokinetics of paliperidone.


METHODS
Six schizophrenic patients initially received a 6-12 mg/d dose of paliperidone alone. Subsequently, a 200 mg/d dose of carbamazepine was administered, and the carbamazepine dose was increased to 400 mg/d and then 600 mg/d. Plasma concentrations of paliperidone before and after carbamazepine coadministration were quantified using liquid chromatography tandem mass spectrometry (LC-MS/MS).


RESULTS
Carbamazepine significantly reduced the plasma concentration of paliperidone. The plasma concentration of paliperidone at baseline and with coadministration of 200, 400, and 600 mg/d were 45.8 ± 11.7, 26.9 ± 13.7, 17.1 ± 8.2, and 15.9 ± 7.6 ng/mL, respectively. The concentration of paliperidone with carbamazepine coadministration at doses of 200, 400, and 600 mg/d were 55.7% ± 20.7%, 36.1% ± 12.2%, and 33.6% ± 10.4%, respectively, of baseline. This effect occurred even at the carbamazepine dose of 200 mg/d and reached a plateau at doses higher than 400 mg/d. However, carbamazepine coadministration exacerbated the psychotic symptoms in some patients.


CONCLUSIONS
The results of the present study suggest that adjunctive treatment with carbamazepine reduces the concentration of paliperidone in a dose-dependent manner, most likely because of the induction of several drug-metabolizing enzymes and several drug transporters.
Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Norio
N
Yasui-Furukori
Kazutoshi
K
Kubo
Masamichi
M
Ishioka
Shoko
S
Tsuchimine
Yoshimasa
Y
Inoue
D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000097:blood* / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D007555:Isoxazoles / Q000097:blood* / Q000627:therapeutic use*; D000068882:Paliperidone Palmitate; D011743:Pyrimidines / Q000097:blood* / Q000627:therapeutic use*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D002220:Carbamazepine; D000068882:Paliperidone Palmitate