Fluorescence studies, DNA binding properties and antimicrobial activity of a dysprosium(III) complex containing 1,10-phenanthroline.
Luminescence and binding properties of dysprosium(III) complex containing 1,10-phenanthroline (phen), [Dy(phen)2(OH2)3Cl]Cl2⋅H2O with DNA has been studied by electronic absorption, emission spectroscopy and viscosity measurement. The thermodynamic studies suggest that the interaction process to be endothermic and entropically driven, which indicates that the dysprosium(III) complex might interact with DNA by a non intercalation binding mode. Additionally, the competitive fluorescence study with ethidium bromide and also the effect of iodide ion and salt concentration on fluorescence of the complex-DNA system is investigated. Experimental results indicate that the Dy(III) complex strongly binds to DNA, presumably via groove binding mode. Furthermore, the complex shows a potent antibacterial activity and DNA cleavage ability.
Department of Chemistry, University of Sistan & Baluchestan, P.O. Box 98155-147, Zahedan, Iran. Electronic address: mkhorasani@chem.usb.ac.ir.
Mozhgan
M
Khorasani-Motlagh
Meissam
M
Noroozifar
Asieh
A
Moodi
Sona
S
Niroomand
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D001667:Binding, Competitive; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects; D004419:Dysprosium / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics; D014783:Viscosity
D000900:Anti-Bacterial Agents; D007454:Iodides; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D004419:Dysprosium; D004247:DNA; C025205:1,10-phenanthroline
Antibacterial activity; Binding constant; DNA binding; Dysprosium complex; Thermodynamic parameters