Cochlear implantation for chronic electrical stimulation in the mouse.
The mouse is becoming an increasingly attractive model for auditory research due to the number of genetic deafness models available. These genetic models offer the researcher an array of congenital causes of hearing impairment, and are therefore of high clinical relevance. To date, the use of mice in cochlear implant research has not been possible due to the lack of an intracochlear electrode array and stimulator small enough for murine use, coupled with the difficulty of the surgery in this species. Here, we present a fully-implantable intracochlear electrode stimulator assembly designed for chronic implantation in the mouse. We describe the surgical approach for implantation, as well as presenting the first functional data obtained from intracochlear electrical stimulation in the mouse.
Bionics Institute, Melbourne, Australia; Department of Psychology, University of Melbourne, Australia.
S
S
Irving
M I
MI
Trotter
J B
JB
Fallon
R E
RE
Millard
R K
RK
Shepherd
A K
AK
Wise
D000818:Animals; D001306:Auditory Pathways; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000502:physiology; D003051:Cochlea / Q000502:physiology; D019929:Cochlear Implantation; D003054:Cochlear Implants; D003638:Deafness / Q000139:chemically induced / Q000534:rehabilitation; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004867:Equipment Design; D006309:Hearing; D051379:Mice; D008810:Mice, Inbred C57BL; D009355:Neomycin / Q000009:adverse effects; D013199:Stapes / Q000098:blood supply
D009355:Neomycin