Bone marrow aspirate concentrate used with bovine bone mineral to reconstruct vertical and horizontal mandibular defects: report of two techniques.
OBJECTIVE
Following initial positive reports of the use of bone marrow aspirate concentrate (BMAC) in combination with bovine bone mineral (BBM) in augmentation procedures, the technique was evaluated in patients with mandibular deficiency.


METHODS
Two adult patients required surgical correction of a deficient alveolar ridge (one patient showed horizontal deficiency only, and the other patient presented with horizontal and vertical deficiency) prior to dental implant placement. In both patients, the reconstruction was performed with BBM in combination with mononuclear cells concentrated by the BMAC method using different techniques.


RESULTS
The patients recovered well from all surgical procedures. Histologically, there was uniform bone formation, which allowed placement of dental implants.


CONCLUSIONS
The results suggest that the use of BMAC in combination with BBM, without autogenous bone, has the potential to restore horizontal and vertical mandibular alveolar defects, providing a functional bone structure and allowing dental implant placement for subsequent prosthetic rehabilitation.
Sebastian
S
Sauerbier
Bernd
B
Giessenhagen
Wolfgang
W
Gutwerk
Petra
P
Rauch
Samuel P
SP
Xavier
Toshiyuki
T
Oshima
Heiner
H
Nagursky
Ralf
R
Gutwald
Rainer
R
Schmelzeisen
D000328:Adult; D000539:Alveolar Process / Q000601:surgery; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001853:Bone Marrow; D016026:Bone Marrow Transplantation / Q000379:methods*; D002417:Cattle; D002469:Cell Separation / Q000379:methods; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D063175:Mandibular Reconstruction / Q000379:methods*; D008875:Middle Aged; D008903:Minerals; D010012:Osteogenesis
D008903:Minerals