Microwave-assisted hydrogenation of codeine in aqueous media.
An efficient one-pot microwave-assisted hydrogenation of codeine was achieved in aqueous solution. This technique is simple, fast, environmentally friendly, and highly efficient. Structure of produced dihydrocodeine was approved by using FT-IR, (1)H NMR, (13)C NMR, EIMS, and elemental analysis technique. Its purity analysis was performed by using HPLC and assay analysis was performed by using potentiometric titration methods.
Department of Chemical Engineering, Faculty of Engineering, Uşak University, 64200 Uşak, Turkey.
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