[Advances in the research of the biological activities of degradation products of extracellular matrix].
ECM is a supporting structure for stabilizing the location of cells and preserving the structure of tissues. Recently, it has been discovered that ECM and its degradation products may exert profound influences on tissues and cells, such as activities of inflammatory cells and immune cells. Angiogenesis may be stimulated or inhibited by degradation products of ECM. Matrikines, liberated by partial proteolysis of ECM macromolecules, are found to regulate cell functional activities and play a significant role in wound healing or tumor invasion. Post-burn denatured dermal matrix is being studied in burn healing now. The study of post-burn denatured or necrotic dermal matrix should be emphasized in future.
Institute of Tissue Engineering of Shandong University, Department of Burns and Plastic Surgery, the Second Hospital of Shandong University, Ji'nan 250033, China.
Xu-guo
XG
Zhu
Du-yin
DY
Jiang
Chuan
C
Li
Guan-ying
GY
Yu
D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D014945:Wound Healing