Evolution of tumefactive lesions in multiple sclerosis: a 12-year study with serial imaging in a single patient.
We describe the acute presentation and the long-term evolution of recurrent tumefactive lesions (TLs) in a patient with relapsing-remitting multiple sclerosis. Five TLs occurred on three different occasions over a period of 12 years and these were followed by 73 serial magnetic resonance images (MRI). TL evolution was described by means of magnetization transfer imaging (MTI) and cerebrospinal fluid tissue specific imaging (TSI) over the follow-up period. During the study period, the patient had three clinical relapses with only minimal disability progression. MTI demonstrated that only the peripheral portion of each TL reverted to pre-lesional MT ratios within six months' post-enhancement. Recurring TLs may present a similar pattern of evolution that may be associated with a long-term favourable clinical outcome.
Department of Bioengineering, Volgenau School of Engineering, George Mason University, USA.
Vasiliki N
VN
Ikonomidou
Nancy D
ND
Richert
Alexander
A
Vortmeyer
Fernanda
F
Tovar-Moll
Bibiana
B
Bielekova
Natalie E
NE
Cook
Jeff H
JH
Duyn
Francesca
F
Bagnato
D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D000077561:Daclizumab; D018450:Disease Progression; D000068717:Glatiramer Acetate; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy / Q000473:pathology*; D004676:Myelin Basic Protein / Q000627:therapeutic use; D010446:Peptide Fragments / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use
D061067:Antibodies, Monoclonal, Humanized; C415587:CGP 77116; D007074:Immunoglobulin G; D007155:Immunologic Factors; D004676:Myelin Basic Protein; D010446:Peptide Fragments; D010455:Peptides; D000068717:Glatiramer Acetate; D016899:Interferon-beta; D000077561:Daclizumab; D000068556:Interferon beta-1a
Multiple sclerosis; magnetic resonance imaging; magnetization transfer imaging; recovery; tissue-specific imaging; tumefactive lesion