Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor.
Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.
Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont "A. Avogadro", via Solaroli 17, 28100 Novara, Italy. Electronic address: filippo.reno@med.unipmn.it.
Filippo
F
Renò
Manuela
M
Rizzi
Marco
M
Invernizzi
Mario
M
Migliario
Carlo
C
Cisari
D000328:Adult; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D063065:Organophosphonates / Q000494:pharmacology*; D011106:Polyisoprenyl Phosphates / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000819:agonists / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism
D063065:Organophosphonates; D011106:Polyisoprenyl Phosphates; D011965:Receptors, Glucocorticoid; D012717:Sesquiterpenes; C004808:farnesyl pyrophosphate
Amino-bisphosphonate; Glucocorticoid receptor; Human keratinocyte