Synthesis of new fused benzothiadiazepines and macrocyclic sulfamides starting from n,n-disubstituted sulfamides and n(boc)-sulfamides.
Herein, we describe an efficient one-step synthesis of new fused benzothiadiazepine-1,1-dioxides and macrocyclic sulfamides. The synthesis of these compounds was achieved in moderate yields starting from previously described N,N'-disubstituted symmetric sulfamides and N-tert-butoxycarbonyl, N'-alkyl sulfamide. The chemical structures of all the new compounds reported in this work were confirmed by NMR, IR, and mass spectrometry. These compounds are beneficial building blocks that can be used in deriving new chemical entities that exert a wide spectrum of pharmacological activities.
Chemistry of Heterocycles Group, Laboratory of Applied Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Annaba, P.O. Box 12, Annaba 23000, Algeria ; Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Mohamed
M
Dehamchia
Zine
Z
Regainia