Adolescent blood pressure hyperreactors have a higher reactive hyperemic index at the fingertip.
OBJECTIVE
The use of peripheral arterial tonometry (PAT) to assess microvascular endothelial function is getting increasingly popular in the pediatric population. The aim of the present study was to examine the impact of blood pressure (BP) hyperreactivity on microvascular hyperemic reaction in healthy, normotensive adolescents.


METHODS
Fifty-two adolescents with a mean age of 14.5 ± 0.7 years were investigated. Microvascular endothelial function was assessed at rest and after exhaustive cycling exercise using PAT to determine the reactive hyperemic index (RHI, primary endpoint). Hyperreactors were identified according to their cardiovascular response to a cold pressor test. Indices of autonomic tone were assessed with an ambulatory electrocardiograph and cardiopulmonary exercise testing was performed on a cycle ergometer. Physical activity was measured using accelerometry. ANOVA with repeated measures and Tukey HSD post hoc tests were applied to determine differences between BP hyperreactors and controls (normal reactors).


RESULTS
Sixteen adolescents were identified as hyperreactors and matched with regard to age, sex, pubertal status, and height with 16 normal reactors. At rest, hyperreactors had a significantly higher RHI than normal reactors (2.1 ± 0.4 vs. 1.6 ± 0.4, P = 0.003). After exhaustive cycling exercise, the differences in RHI were abolished. No differences between these two groups existed in physical activity levels, exercise capacity and indices of autonomic tone.


CONCLUSIONS
Our data suggest that normotensive hyperreactors have a markedly higher RHI compared to normal reactors. Future studies using PAT to assess microvascular endothelial function should bare in mind the large effect of vascular hyperreactivity.
Thomas
T
Radtke
Prisca
P
Eser
Susi
S
Kriemler
Hugo
H
Saner
Matthias
M
Wilhelm
D000293:Adolescent; D001794:Blood Pressure; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology; D015444:Exercise; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D008297:Male; D012039:Regional Blood Flow