Acquired Bartter-like syndrome association with netilmicin therapy in an extremely low birth weight infant.
Aminoglycosides are commonly used antibiotics with excellent renal parenchymal penetration. Their clinical effectiveness is counter balanced with the risk of renal toxicity, which develops in a dose-dependent fashion. Aminoglycoside-induced renal tubular dysfunction could result in diffuse damage or manifest as a Fanconi-like syndrome, Bartter-like syndrome (BLS), or distal renal tubular acidosis.(1-4) Although tubulopathy associated with amikacin and gentamicin was reported in adults and rarely children, to the best of our knowledge, netilmicin-associated BLS neither in adults nor in children has been reported in the literature. We here report a 30-week, 770 g male preterm infant who developed BLS just after netilmicin treatment for neonatal sepsis and recovered 6 weeks after the drug cessation.
Department of Neonatology, Faculty of Medicine, Suleyman Demirel University , Isparta , Turkey.
Gonca
G
Sandal
Şenay
Ş
Akbay
Metehan
M
Ozen
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001477:Bartter Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D009428:Netilmicin / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D018805:Sepsis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D009428:Netilmicin