PSMA/PSA ratio evaluated by immunohistochemistry may improve diagnosis of prostate cancer.
Prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) measured in serum are not fully satisfactory as biomarkers of prostate cancer (PC). Results obtained in this article indicated that PSMA/PSA ratio evaluated by immunohistochemistry in normal prostate (NP), benign prostatic hyperplasia (BPH), and PC at the individual level could be a useful tool for diagnosis and prognosis of PC. PSMA and PSA were equally expressed in NP and the PSMA/PSA ratio was 1.22 ± 0.15. Data also indicated that PSMA/PSA ratio fluctuates in BPH and PC compared to NP. In BPH, the PSMA/PSA ratio was around 0.47 ± 0.02, whereas it's significantly increased in PC, about 4.95 ± 0.83. In parallel, the highest PSMA/PSA ratio was associated with high intratumoral angiogenesis in PC patients with (PSMA+,PSA+) profile.
a Unit of Immunology and Microbiology Environmental and Carcinogenesis (IMEC), University of Carthage , Zarzouna , Tunisia.
Awatef Ben
AB
Jemaa
Yosra
Y
Bouraoui
Sataa
S
Sallami
Ahmed
A
Banasr
Yassine
Y
Nouira
Ridha
R
Oueslati
D000230:Adenocarcinoma / Q000098:blood supply / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D015870:Gene Expression; D043425:Glutamate Carboxypeptidase II / Q000097:blood / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011467:Prostate / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood / Q000235:genetics*; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
D000954:Antigens, Surface; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D017430:Prostate-Specific Antigen