Synthesis of the C1-C25 southern domain of spirastrellolides B and F.
Synthesis of the C1-C25 ABC spiroketal ring system of spirastrellolides B and F has been executed. The synthetic strategy relied on radical cyclization, HWE olefination, (BDP)CuH conjugate reduction and spiro acetalization reactions.
Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India. gowravaramsr@yahoo.com sabitha@iict.res.in.
Gowravaram
G
Sabitha
Allu Senkara
AS
Rao
J S
JS
Yadav
D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D018942:Macrolides; D013141:Spiro Compounds; C519027:spirastrellolide B; C547153:spirastrellolide F methyl ester