Effect of fluoride gels supplemented with sodium trimetaphosphate in reducing demineralization.
OBJECTIVE
The objective of this study was to evaluate the in vitro effect of low-fluoride (F) gels supplemented with sodium trimetaphosphate (TMP) on enamel demineralization.


METHODS
Bovine enamel blocks (n = 160) were selected based on surface hardness (SH) and divided into eight treatment groups (n = 20 per group): no F or TMP (placebo), 3 % TMP (3 %TMP), 5 % TMP (5 %TMP), 4,500 μg F/g (4,500), 4,500 μg F/g + 3 % TMP (4,500 3 %TMP), 4,500 μg F/g + 5 % TMP (4,500 5 %TMP), 9,000 μg F/g (9,000), and 12,300 μg F/g (acid gel). Blocks were subjected to demineralization/remineralization cycling for 5 days. Subsequently, surface hardness (SH1) and integrated loss of subsurface hardness (ΔKHN) were assessed, and the concentrations of loosely bound (CaF2-like) and firmly bound (FA-like) formed and retained F were determined.


RESULTS
The 4,500 5 %TMP and acid gel groups showed similar results and had the lowest mineral loss (SH1 and ∆KHN). The acid gel group had the highest concentration of CaF2-like F, but the formation and retention of FA-like F was greater in the 4,500 5 %TMP group than in the acid gel group (p < 0.05).


CONCLUSIONS
It is possible to inhibit enamel demineralization with low-F gels supplementing these gels with 5 % TMP.


CONCLUSIONS
The low-F gel containing TMP can be regarded as a safer alternative for clinical use from a toxicological point of view since it contains half of the amount of a conventional formulation while promoting similar anticaries effect.
Department of Pediatric Dentistry and Public Health, Araçatuba School of Dentistry, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil.
Marcelle
M
Danelon
Department of Pediatric Dentistry and Public Health, Araçatuba School of Dentistry, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil.
Eliana Mitsue
EM
Takeshita
Department of Pediatric Dentistry and Public Health, Araçatuba School of Dentistry, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil.
Ligia Carla
LC
Peixoto
Basic Sciences Department, Araçatuba School of Dentistry, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil.
Kikue Takebayashi
KT
Sassaki
Department of Pediatric Dentistry and Public Health, Araçatuba School of Dentistry, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil. adelbem@foa.unesp.br.
Alberto Carlos Botazzo
ACB
Delbem
D005459:Fluorides / Q000008:administration & dosage*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D011122:Polyphosphates / Q000008:administration & dosage*; D017001:Tooth Demineralization
D005782:Gels; D011122:Polyphosphates; C009293:trimetaphosphoric acid; D005459:Fluorides