A bloody mess: dendritic cells use hemophagocytosis to regulate viral inflammation.
Previous studies have highlighted the immune-dampening effects of apoptotic cell uptake by phagocytes. Ohyagi et al. (2013) expose a unique mechanism of immune regulation during viral infection, which is mediated through phagocytosis of apoptotic red cells by dendritic cells.
Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Elizabeth
E
Miller
Nina
N
Bhardwaj
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D010587:Phagocytosis