Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease.
BACKGROUND
Animal studies show that von Willebrand factor (vWF) deficiency is associated with lower risks for atherosclerosis and atherothrombosis, including events such as acute myocardial infarction and ischemic stroke. vWF enables the binding of platelets along the damaged vessels leading to thrombogenesis. Interruption of this early stage of thrombus formation may prevent downstream amplification of the inflammatory and thrombotic processes that contribute to the plaque instability.


METHODS
Increased levels of vWF have been related to the atherothrombotic complications and endothelial damage. Therefore, vWF has been suggested as a useful biomarker of endothelial damage/dysfunction. Preliminary data from Phase II trials in patients with acute myocardial infarction and thrombotic disorders have been promising, but many unanswered questions remain regarding the optimal therapeutic use of vWF blockade. This article describes the molecular structure of vWF, its functions and its interactions with the platelet membrane glycoprotein (GP) receptors GPIb and GPIIb-IIIa, as well as collagen. In addition, the article provides an overview of most promising investigational compounds tested as antithrombotic agents targeting vWF.


METHODS
Preclinical and clinical data for vWF blockage are discussed.


CONCLUSIONS
The therapeutic approaches aiming to block the collagen-vWF-platelet axis have potentially beneficial effects for prevention and treatment of cardiovascular disease. However, the evidence directly associating vWF blockage with beneficial clinical outcomes is limited and needs further research. Optimal treatment regimes need to be established in relation of specific clinical circumstances and conditions.
University of Birmingham Centre for Cardiovascular Sciences, City Hospital , Birmingham, B18 7QH , UK.
Silvia
S
Montoro-García
Eduard
E
Shantsila
Gregory Y H
GY
Lip
D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D015539:Platelet Activation; D011487:Protein Conformation; D059748:Proteolysis; D014841:von Willebrand Factor / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology
D014841:von Willebrand Factor