Radical trachelectomy: the first step of fertility preservation in young women with cervical cancer (Review).
Radical trachelectomy (RT) can be performed vaginally or abdominally (laparotomic, laparoscopic or robotic). The aim of this systematic review was to compare all techniques in terms of surgical complications, disease recurrence and subsequent fertility/pregnancy outcomes. A total of 1293 RTs were analyzed (FIGO-stage: IA1-IIA). The most frequent surgical complications do not differ from the ones of radical hysterectomy. The recurrence risk is approximately 3% (range 0-16.8%). The majority of women conceive spontaneously: 284 pregnancies with 173 live births. The most frequent pregnancy complication was miscarriage and chorioamnionitis. RT appears to be a safe option for eligible women who intend to maintain their future pregnancy desire.
Department of Women's and Children's Health, University of Padua, Padua, Italy.
Salvatore
S
Gizzo
Emanuele
E
Ancona
Carlo
C
Saccardi
Tito Silvio
TS
Patrelli
Roberto
R
Berretta
Omar
O
Anis
Marco
M
Noventa
Anna
A
Bertocco
Simone
S
Fagherazzi
Michela
M
Longone
Lucia
L
Vendemiati
Donato
D
D'Antona
Giovanni Battista
GB
Nardelli
D005260:Female; D005298:Fertility; D006801:Humans; D007044:Hysterectomy; D050498:Live Birth; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*