Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.
Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Box 3050, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Bryan D
BD
Choi
Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Box 3050, Durham, NC 27710, USA.
Carter M
CM
Suryadevara
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Patrick C
PC
Gedeon
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
James E
JE
Herndon
Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Box 3050, Durham, NC 27710, USA.
Luis
L
Sanchez-Perez
Department of Pathology, Duke University Medical Center, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.
Darell D
DD
Bigner
Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Box 3050, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA. Electronic address: john.sampson@duke.edu.
John H
JH
Sampson
D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology; D045744:Cell Line, Tumor; D002678:Chimera; D066246:ErbB Receptors / Q000235:genetics / Q000276:immunology*; D005910:Glioma / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D014161:Transduction, Genetic; D023041:Xenograft Model Antitumor Assays
D011948:Receptors, Antigen, T-Cell; C410723:epidermal growth factor receptor VIII; D066246:ErbB Receptors
Central nervous system neoplasms; Epidermal growth factor receptor; Glioblastoma; Immunotherapy; T-lymphocytes