Clinical significance of serum BAP, TRACP 5b and ICTP as bone metabolic markers for bone metastasis screening in lung cancer patients.
BACKGROUND
We investigated the clinical significance of serum bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) and type I collagen carboxyterminal telopeptide (ICTP) as bone metabolic markers for bone metastasis (BM) screening in lung cancer patients.


METHODS
Newly diagnosed advanced lung cancer patients with (N = 130) and without (N = 135) BM were enrolled in the study. Serum BAP, TRACP 5b and ICTP were measured before the treatment.


RESULTS
BAP, TRACP 5b and ICTP values were higher in patients with BM compared with patients without BM (all P < 0.0001). Area under ROC curve (AUC) of BAP, TRACP 5b and ICTP was 0.760, 0.753 and 0.835 (all P < 0.0001), respectively. The cut-off values for BAP, TRACP 5b and ICTP were 21.8 μg/l, 7.8 U/l and 8.8 μg/l, respectively. When TRACP 5b and ICTP were combined, AUC was elevated to 0.895 (P < 0.0001), and the cut-off values were TRACP 5b 7.6 U/l and ICTP 8.4 μg/l.


CONCLUSIONS
We conclude that serum BAP, TRACP 5b and ICTP may serve as useful tools for BM screening in lung cancer patients.
Department of Lung Cancer, Affiliated Hospital of Academy of Military Medical Sciences, No. 8 Dongdajie, Beijing 100071, China.
Chuanhao
C
Tang
Yi
Y
Liu
Haifeng
H
Qin
Xiaoyan
X
Li
Wanfeng
W
Guo
Jianjie
J
Li
Weixia
W
Wang
Lili
L
Qu
Haixu
H
Hu
Chunhong
C
Xu
Li
L
Zheng
Yaohua
Y
Huang
Bing
B
Liu
Hongjun
H
Gao
Jussi M
JM
Halleen
Xiaoqing
X
Liu
D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary*; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D000071681:Tartrate-Resistant Acid Phosphatase; D055815:Young Adult
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D007527:Isoenzymes; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase
Bone metabolic markers; Bone metastasis; Bone-specific alkaline phosphatase (BAP); Tartrate-resistant acid phosphatase isoform 5b (TRACP 5b); Type I collagen carboxyterminal telopeptide (ICTP)