Usefulness of Atopy Patch Test on a child with milk protein-induced enterocolitis syndrome: a case report.
We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon nonIgE-mediated gastrointestinal food hypersensitivity of infancy, characterized by severe vomiting and diarrhea arising within 1 to 3 hours after ingestion of the causative food. Little is known about the pathophysiology of FPIES. The absence of food-specific IgE as demonstrated by negative skin prick tests suggests that the disease is not caused by an early onset IgE-mediated reaction. Atopy Patch Test has been described as sensitive and predictive in this syndrome. The hypothesis on the immunological pathogenesis has been discussed on the basis of literature data.
Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, Italy.
A
A
Scaparrotta
S
S
Di Pillo
N P
NP
Consilvio
M
M
Attanasi
A
A
Cingolani
D
D
Rapino
M
M
Cerasa
N
N
Pucci
M
M
Di Gioacchino
F
F
Chiarelli
D001942:Breast Feeding; D004760:Enterocolitis / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007223:Infant; D041943:Infant Formula; D008297:Male; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D008894:Milk Proteins / Q000009:adverse effects*; D010328:Patch Tests; D011237:Predictive Value of Tests; D013577:Syndrome
D008894:Milk Proteins