Antitumour and antioxidant potential of some selected Pakistani honeys.
Antitumour potential of honey is attributed to its excellent antioxidant activity which in turn depends on the geographical origin. The present study focuses on exploration of antioxidant and antitumour potential as well as total phenolic contents (TPC) of 58 Pakistani honeys involving spectrochemical techniques and potato disk assay. Agrobacterium tumefaciens was used to induce tumours in potato disks. All analysed honey samples exhibited 1.33±0.00-155.16±0.98mg/100g of TPC, 50% 2,2-diphenyl picryl hydrazyl (DPPH) inhibition, ⩾7.36±0.43-39.86±2.34mg/100g qurecitin equivalent antioxidant contents, ⩾13.69±0.91-65.50±1.37mg/100g ascorbic acid equivalent antioxidant contents, 64.65±0.43-1780.74±11.79mM ferric reducing antioxidant power and 60% peroxide inhibition. Antitumour activity observed for 43 natural and 10 commercial samples was ⩾20%. Two samples from Faisalabad region showed 87.50±5.50% and 79.00±5.56% antitumour activity which were reference standard. It was concluded that Pakistani honeys possessed excellent antioxidant and antitumour potential overall.
Department of Chemistry and Biochemistry, University of Agriculture, 38040 Faisalabad, Pakistan.
Nadia
N
Noor
Raja Adil
RA
Sarfraz
Shaukat
S
Ali
Muhammad
M
Shahid
D016960:Agrobacterium tumefaciens / Q000187:drug effects / Q000502:physiology; D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D006722:Honey / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010154:Pakistan; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D010941:Plant Tumors / Q000382:microbiology*; D011198:Solanum tuberosum / Q000382:microbiology
D000970:Antineoplastic Agents; D000975:Antioxidants; D010636:Phenols
Agrobacterium tumefaciens; Antioxidant potential; Antitumour activity; Honey; Potato disc assay