A concise and efficient total synthesis of α-mangostin and β-mangostin from Garcinia mangostana.
The concise, efficient synthesis of alpha-mangostin is described in eight simple steps with 8.3% overall yield. Highlights include a practical approach to construct the isopentene groups and other diverse groups at C-2 and C-8 of the xanthene skeleton through Claisen rearrangement and Wittig reaction. Meanwhile the first total synthesis of beta-mangostin is presented with a similar approach.
Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Dandan
D
Xu
Ying
Y
Nie
Xizhou
X
Liang
Ling
L
Ji
Songyuan
S
Hu
Qidong
Q
You
Fan
F
Wang
Hongchun
H
Ye
Jinxin
J
Wang
D029760:Garcinia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D044004:Xanthones / Q000138:chemical synthesis*
D044004:Xanthones; C021053:mangostin