Efficient one-pot synthesis of novel and diverse tetrahydroquinolines bearing pyranopyrazoles using organocatalyzed domino Knoevenagel/hetero Diels-Alder reactions.
A new synthetic route to biologically interesting diverse tetrahydroquinolines bearing pyranopyrazoles was developed by reacting pyrazolones and N, N-dialkylated aminobenzaldehydes in the presence of EDDA. The key strategy underlying the methodology used was the domino Knoevenagel/hetero Diels-Alder reaction. This synthetic method provides a variety of novel tetrahydroquinolines in good yields.
School of Chemical Engineering, Yeungnam University, Gyeongsan , 712-749, Republic of Korea.
Rameshwar Prasad
RP
Pandit
Yong Rok
YR
Lee
D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
D001547:Benzaldehydes; D011720:Pyrazoles; D011804:Quinolines; C026058:EDDA; D004492:Edetic Acid; C542964:1,2,3,4-tetrahydroquinoline; C032175:benzaldehyde