Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.
Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.
a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
Lucas S
LS
Broster
Juan
J
Li
Charles D
CD
Smith
Gregory A
GA
Jicha
Frederick A
FA
Schmitt
Yang
Y
Jiang
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D000647:Amnesia / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D012307:Risk Factors