Design, synthesis and evaluation of a boronic acid based artificial receptor for (L)-DOPA in aqueous media.
Design and synthesis of a boronic acid based artificial receptor which selectively and effectively bound to a neurotransmitter, l-DOPA (), in aqueous media. In addition, the synthetic receptor was found to effectively inhibit the DDC (l-DOPA decarboxylase) enzymatic reaction under physiological conditions.
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. dtak@applc.keio.ac.jp toshima@applc.keio.ac.jp.
Haruna
H
Ueno
Takayuki
T
Iwata
Nozomi
N
Koshiba
Daisuke
D
Takahashi
Kazunobu
K
Toshima
D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D007980:Levodopa / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D001897:Boronic Acids; D014867:Water; D007980:Levodopa