Metal-free bioconjugation reactions.
The recent strategy to apply chemical reactions to address fundamental biological questions has led to the emergence of entirely new conjugation reactions that are fast and irreversible, yet so mild and selective that they can be performed even in living cells or organisms. These so-called bioorthogonal reactions open novel avenues, not only in chemical biology research, but also in many other life sciences applications, including the modulation of biopharmaceuticals by site-specific modification approaches.
Sander S
SS
van Berkel
Floris L
FL
van Delft
D002625:Chemistry, Organic / Q000379:methods*; D015195:Drug Design; D055601:Organic Chemistry Phenomena