Neural stem and progenitor cells in health and disease.
Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs, the regulation of NSPC fate and function, in the context of cell-based disease models and patient-specific cell-replacement therapies, warrants review.
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
Ian
I
Ladran
Ngoc
N
Tran
Aaron
A
Topol
Kristen J
KJ
Brennand
D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D008959:Models, Neurological; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D058953:Neural Stem Cells / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology