NF-E2-related factor 2 and its role in diabetic nephropathy.
Diabetic nephropathy is the leading cause of chronic kidney disease and end-stage renal disease. Oxidative stress has been recognized as a major contributor to its pathogenesis. Defensive mechanisms have also widely been studied. One of them, the NF-E2-Related Factor 2, is reviewed in this article.
Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. fakhoshjoo@yahoo.com.
Farahnaz
F
Dadras
Farhad
F
Khoshjou
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D017879:Isothiocyanates / Q000494:pharmacology; D000072019:Kelch-Like ECH-Associated Protein 1; D051379:Mice; D051267:NF-E2-Related Factor 2 / Q000187:drug effects / Q000378:metabolism*; D013454:Sulfoxides
D048868:Adaptor Proteins, Signal Transducing; D000806:Angiotensin-Converting Enzyme Inhibitors; D016588:Anticarcinogenic Agents; D003598:Cytoskeletal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D017879:Isothiocyanates; C431364:KEAP1 protein, human; C117301:Keap1 protein, mouse; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; D013454:Sulfoxides; C016766:sulforaphane