[Vitamin D and autoimmunity].
Vitamin D acts at several levels in the immune systems to maintain immune tolerance. Vitamin D deficiency is a plausible environmental risk factor for autoimmune disease. Basic, genetic and epidemiological studies indicate a potential role of vitamin D in the prevention and the treatment of autoimmune diseases. Most of the epidemiological studies are cross-sectional, so that they are insufficient to establish a direct link between vitamin D deficiency and both disease risk and disease activity. Randomized, controlled trials are necessary.
Hôpital de la Pitié-Salpêtrière, service de médecine interne 1, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: yoland.schoindre@psl.aphp.fr.
Yoland
Y
Schoindre
Olivier
O
Benveniste
Nathalie
N
Costedoat-Chalumeau
D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D015551:Autoimmunity / Q000235:genetics / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000502:physiology; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology / Q000502:physiology; D012213:Rheumatic Fever / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000628:therapy
D014807:Vitamin D