Tuning of cell-biomaterial anchorage for tissue regeneration.
Which mechanisms mediate cell attachment to biomaterials? What role does the surface charge or wettability play on cell-material anchorage? What are the currently investigated strategies to modify cell-matrix adherence spatiotemporally? Considering the development of scaffolds made of biocompatible materials to temporarily replace the structure and/or function of the extracellular matrix, focus is given to the analysis of the specific (i.e., cell adhesive peptide sequences) and unspecific (i.e., surface charge, wettability) mechanisms mediating cell-matrix interactions. Furthermore, because natural tissue regeneration is characterized by the dynamic attachment/detachment of different cell populations, the design of advanced scaffolds for tissue engineering, based in the spatiotemporal tuning of cell-matrix anchorage is discussed.
Institute of Biomaterials, Friedrich-Alexander Universität Erlangen Nürnberg, Cauerstraße 6, 91058 Erlangen, Germany. aldoleal@yahoo.com
Aldo
A
Leal-Egaña
Aránzazu
A
Díaz-Cuenca
Aldo R
AR
Boccaccini
D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002448:Cell Adhesion / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism*; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds