Stimuli responsive elastin-like polypeptides and applications in medicine and biotechnology.
Elastin-like polypeptides (ELPs) are artificial biopolymers composed of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly. They are a class of stimuli responsive biopolymers exhibiting an inverse temperature transition, which are particularly attractive in biological applications. In this paper, the methods of synthesizing ELPs and the applications in medicine and biotechnology such as purification of fusion proteins, drug delivery, and tissue engineering are reviewed. In addition, further perspective will be presented.
a Tianjin Key Laboratory of Composite and Functional Materials , , Tianjin , 300072 , P.R. China .
Yuezai
Y
Shang
Yufang
Y
Yan
Xin
X
Hou
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D004549:Elastin / Q000737:chemistry*; D006801:Humans; D008511:Medicine / Q000379:methods*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism
D001672:Biocompatible Materials; D010455:Peptides; D004549:Elastin