Molecular and genetic determinants of alcohol dependence.
Alcohol dependence is a complex disorder affecting all social and ethnic groups. Although the scientific understanding of the mechanism governing this multifactorial disease is still in its infancy, understanding its biological bases, including the potential contribution of genetic factors, is key to characterizing individual's risk and developing efficacious therapeutic target to combat the disease. This review provides an overview of different approaches that are being increasingly integrated to extend our knowledge of the genetic underpinnings of alcohol dependence.
a Department of Biological Sciences , Tai Solarin University of Education , Ijagun , Ogun State , Nigeria.
Awoyemi A
AA
Awofala
D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002908:Chronic Disease; D018450:Disease Progression; D004200:Diseases in Twins / Q000235:genetics; D044127:Epigenesis, Genetic / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D051379:Mice; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects; D018009:Receptors, Glycine / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D011985:Receptors, Serotonin / Q000187:drug effects; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects*; D018433:Twin Studies as Topic
D002492:Central Nervous System Depressants; D011950:Receptors, Cholinergic; D018079:Receptors, GABA; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D000431:Ethanol