Ni-Catalyzed [8+3] cycloaddition of tropones with 1,1-cyclopropanediesters.
A variety of cycloheptapyrane derivatives were prepared via Ni-catalyzed formal [8+3] cycloaddition of tropones with 1,1-cyclopropanediesters. The asymmetric version of the process can be achieved using either an enantiomerically enriched cyclopropane as the starting material or a racemic cyclopropane and a chiral Lewis acid.
Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain. javier.adrio@uam.es juancarlos.carretero@uam.es.
Rubén
R
Tejero
Alberto
A
Ponce
Javier
J
Adrio
Juan C
JC
Carretero