Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics.
Extensive efforts have been devoted to the construction of functional supramolecular nanosystems for applications in catalysis, energy conversion, sensing and biomedicine. The applications of supramolecular nanosystems such as liposomes, micelles, inorganic nanoparticles, carbon materials for cancer diagnostics and therapeutics have been reviewed by other groups. Here, we will focus on the recent momentous advances in the implementation of typical supramolecular hosts (i.e., cyclodextrins, calixarenes, cucurbiturils and metallo-hosts) and their nanosystems in cancer diagnostics and therapeutics. We discuss the evolutive process of supramolecular nanosystems from the structural control and characterization to their diagnostic and therapeutic function exploitation and even the future potentials for clinical translation.
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao Zhongguancun Haidian District, Beijing 100190, PR China.
Lei
L
Wang
Li-li
LL
Li
Yun-shan
YS
Fan
Hao
H
Wang
D000818:Animals; D047250:Calixarenes / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D000099246:Cucurbit(n)urils
D047250:Calixarenes; D003505:Cyclodextrins; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
cancer; diagnostics; nanoparticles; supramolecular; therapeutics