MCP-1-2518A>G polymorphism and myocardial infarction risk: a meta-analysis and meta-regression.
OBJECTIVE
Monocyte chemoattractant protein-1 (MCP-1), a key chemokine in atherosclerotic inflammation, plays an important role in the etiology of myocardial infarction (MI). Emerging evidence has shown that the common polymorphism (-2518A>G; rs1024611) in the MCP-1 gene may contribute to the risk of MI, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of the associations between MCP-1-2518A>G polymorphism and susceptibility to MI.


METHODS
A literature search of PubMed, Embase, Web of Science, and China BioMedicine (CBM) databases was conducted on articles published before May 15th, 2013. The crude odds ratios with 95% confidence intervals were calculated.


RESULTS
Eleven case-control studies were included with a total 2325 MI patients and 6310 healthy controls. The meta-analysis results indicated that MCP-1-2518A>G polymorphism was associated with an increased risk of MI. In further subgroup analysis based on ethnicity, there were significant associations between MCP-1-2518A>G polymorphism and an increased risk of MI among Asian populations. However, no statistically significant association was found among Caucasian populations. Univariate and multivariate meta-regression analyses showed that ethnicity may be the major source of heterogeneity. No publication bias was detected in this meta-analysis.


CONCLUSIONS
In conclusion, the current meta-analysis indicates that MCP-1-2518A>G polymorphism may be a risk factor for MI, especially among Asian populations.
1 Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University , Beijing, People's Republic of China .
Bin
B
Mao
Jianqun
J
Zhang
Fengling
F
Zhuo
D044466:Asian People; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors; D044465:White People
C111835:CCL2 protein, human; D018932:Chemokine CCL2