Autophagy in infection, inflammation and immunity.
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, North East, Albuquerque, New Mexico 87131, USA.
Vojo
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Deretic
Tatsuya
T
Saitoh
Shizuo
S
Akira
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000276:immunology; D017951:Antigen Presentation; D001343:Autophagy / Q000235:genetics / Q000276:immunology*; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000235:genetics / Q000276:immunology; D007249:Inflammation; D021381:Protein Transport; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology / Q000821:virology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D058847:Inflammasomes; D051192:Receptors, Pattern Recognition