A conserved pattern of differential expansion of cortical areas in simian primates.
The layout of areas in the cerebral cortex of different primates is quite similar, despite significant variations in brain size. However, it is clear that larger brains are not simply scaled up versions of smaller brains: some regions of the cortex are disproportionately large in larger species. It is currently debated whether these expanded areas arise through natural selection pressures for increased cognitive capacity or as a result of the application of a common developmental sequence on different scales. Here, we used computational methods to map and quantify the expansion of the cortex in simian primates of different sizes to investigate whether there is any common pattern of cortical expansion. Surface models of the marmoset, capuchin, and macaque monkey cortex were registered using the software package CARET and the spherical landmark vector difference algorithm. The registration was constrained by the location of identified homologous cortical areas. When comparing marmosets with both capuchins and macaques, we found a high degree of expansion in the temporal parietal junction, the ventrolateral prefrontal cortex, and the dorsal anterior cingulate cortex, all of which are high-level association areas typically involved in complex cognitive and behavioral functions. These expanded maps correlated well with previously published macaque to human registrations, suggesting that there is a general pattern of primate cortical scaling.
Department of Physiology and Monash Vision Group, Monash University, Clayton, Victoria, 3800, Australia, and Programa de Neurobiologia, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Rio de Janeiro 21941-900, Brazil.
Tristan A
TA
Chaplin
Hsin-Hao
HH
Yu
Juliana G M
JG
Soares
Ricardo
R
Gattass
Marcello G P
MG
Rosa
D000818:Animals; D001931:Brain Mapping; D002144:Callithrix; D002428:Cebus; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D008297:Male; D008959:Models, Neurological; D011323:Primates / Q000033:anatomy & histology*