TERRA -a calling card for telomerase.
Transcription of telomeric DNA has long been thought to inhibit telomerase. Using live cell imaging, in this issue, Cusanelli et al. (2013) now reveal a different scenario: telomeric RNA is preferentially generated at short telomeres and delivers telomerase to the chromosome end from which the transcript originated.
Howard Hughes Medical Institute and Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Elena
E
Smekalova
Peter
P
Baumann
D022661:RNA, Untranslated / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D019098:Telomerase / Q000235:genetics*; D059506:Telomere Shortening / Q000235:genetics*
D022661:RNA, Untranslated; D019098:Telomerase