Intralesional cidofovir as adjuvant for the successful management of aggressive respiratory papillomatosis in an infant.
Recurrent respiratory papillomatosis (RRP) in young children is frequently characterized by a recalcitrant course and need for multiple surgeries. Periodic surgical debulking and ablation is the mainstay of therapy as a cure for RRP rarely occurs. Benefits of adjuvant treatment with local injection of cidofovir in aggressive cases of RRP have been reported in both children and adults. However, a consensus on initiation, dosage, or scheduling of this drug has not been established in the very young patient. Literature on successful remission in children less than 1 year of age is not available. One such case of an infant with aggressive RRP treated with local adjuvant cidofovir is described herein.
Arkansas Children's Hospital, United States. Electronic address: phanidurvasula@hotmail.co.uk.
Venkata S P B
VS
Durvasula
Gresham T
GT
Richter
D000998:Antiviral Agents / Q000008:administration & dosage; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D007828:Laryngoscopy / Q000379:methods*; D063065:Organophosphonates / Q000008:administration & dosage*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000601:surgery; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir
Adjuvant; Cidofovir; Infant; Intralesional; Respiratory papillomatosis