Catalytic direct cross-coupling of organolithium compounds with aryl chlorides.
Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd2(dba)3/XPhos as the catalyst allows for the preparation of biaryl and heterobiaryl compounds in high yields under mild conditions (room temperature to 40 °C) with short reaction times.
Stratingh Institute for Chemistry, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Valentín
V
Hornillos
Massimo
M
Giannerini
Carlos
C
Vila
Martín
M
Fañanás-Mastral
Ben L
BL
Feringa