Extraskeletal Ewing's sarcoma arising in the larynx.
Extraskeletal Ewing's sarcoma (EES), or primitive neuroectodermal tumor, is an uncommon neoplasm with low incidence in the head and neck. Occurrences in the larynx are even more exceptional with only two previous reported cases of EES arising from the larynx. We report the case of a 45-year-old woman with a laryngeal Ewing's sarcoma treated with chemotherapy with radiotherapy to follow. Here we describe the histology, molecular diagnosis and treatment of this unusual tumor.
Department of Pathology H179, Penn State Hershey Medical Center, Hershey, PA, 17033, USA, mlynch1@hmc.psu.edu.
Michael C
MC
Lynch
Aaron
A
Baker
Joseph J
JJ
Drabick
Nicole
N
Williams
David
D
Goldenberg
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor