Acute changes in lipoprotein subclasses during exercise.
OBJECTIVE
Lipids are important substrates for oxidation in the basal fasting state and during exercise. Studies have demonstrated beneficial changes in lipoprotein subclass composition the day after an exercise bout. However, the acute effect of exercise on TG concentration and lipoprotein subclass composition remains unclear.


METHODS
Sixteen lean, healthy individuals (8 men and 8 women) were recruited (age 20-30 years, BMI<25 kg/m(2)). The subjects were studied during basal fasting conditions as well as during and after 90 min of cycling at 50% of VO2peak. Lipoprotein subclass composition was measured with (1)H NMR spectroscopy.


RESULTS
During exercise, LDL and HDL particle concentration increased significantly (p<0.05) despite lower total TG concentration. In addition, exercise resulted in a shift towards smaller VLDL particles in men (p<0.05), but VLDL-TG concentration was unaltered.


CONCLUSIONS
Acute exercise induces beneficial changes in lipoprotein subclass composition. These changes are similar to the effects of exercise training.
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. Electronic address: esbens@dadlnet.dk.
Esben
E
Søndergaard
Marianne K
MK
Poulsen
Michael D
MD
Jensen
Søren
S
Nielsen
D000328:Adult; D001642:Bicycling; D001823:Body Composition; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control; D015444:Exercise; D005215:Fasting; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010101:Oxygen Consumption; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides
(1)H NMR; (1)H NMR spectroscopy; BMI; Body mass index; CVD; Cardiovascular disease; DEXA; Dual X-ray absorptiometry; FFA; Free fatty acids; HDL; High density lipoprotein; IDL; Intermediate density lipoprotein; LDL; LPL; Lipoprotein lipase; Low density lipoprotein; Nuclear Magnetic Resonance; Peak oxygen uptake; TG; Triglyceride; VLDL; VO2peak; Very low-density lipoprotein