Influence of chlorhexidine digluconate on the clinical performance of adhesive restorations: a 3-year follow-up.
OBJECTIVE
The aim of this clinical study was to evaluate the long-term clinical performance of non-carious Class V restorations with and without application of chlorhexidine digluconate to acid-etched dentine.


METHODS
After the approval of the Ethics and Informed Consent Committee, 70 non-carious cervical lesions were selected and randomly assigned into two groups, according to the split mouth design. The control group was restored with a two-step etch-and-rinse adhesive (Adper Single Bond 2) following manufacturer's instructions; whereas in the experimental group 2% chlorhexidine digluconate solution was applied to acid etched dentine for 30s after etching and prior to the adhesive application. All lesions were restored with a nanofilled composite resin (Filtek Supreme XT) and polymerized with a light-curing unit operating at 600mW/cm(2). Clinical performance was recorded after 1 week, 6, 12, and 36 months using modified Ryge/USPHS criteria in terms of retention, marginal discoloration, marginal integrity, post-operative sensitivity, and secondary caries incidence. Data were analyzed using Chi-Square, Fisher's exact test and McNemar tests (α=.05).


RESULTS
After 36 months the control group showed a success rate of 88% in comparison to 76% of experimental group; however, no statistically difference between them was found (p=.463). Moreover, no statistical differences were observed between groups in the criteria post-operative sensitivity, marginal discoloration, marginal integrity, and secondary caries incidence between the two groups.


CONCLUSIONS
The addition of 2% chlorhexidine digluconate conditioning step does not improve the clinical durability of adhesive restorations.
Division of Restorative Science, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA. Electronic address: sartori@usc.edu.
Neimar
N
Sartori
Sheila C
SC
Stolf
Silvana B
SB
Silva
Guilherme C
GC
Lopes
Marcela
M
Carrilho
D000134:Acid Etching, Dental / Q000379:methods; D000328:Adult; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003116:Color; D003188:Composite Resins / Q000737:chemistry*; D001840:Dental Bonding; D003731:Dental Caries / Q000209:etiology; D003738:Dental Cements / Q000737:chemistry; D018772:Dental Marginal Adaptation; D003764:Dental Materials / Q000737:chemistry*; D003793:Dental Restoration, Permanent / Q000145:classification*; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D055115:Light-Curing of Dental Adhesives / Q000295:instrumentation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D053761:Nanocomposites / Q000737:chemistry; D011480:Protease Inhibitors / Q000627:therapeutic use*; D013997:Time Factors; D057085:Tooth Wear / Q000628:therapy; D016896:Treatment Outcome
C554641:Adper single bond 2; D003188:Composite Resins; D003738:Dental Cements; D003764:Dental Materials; C474035:Filtek Supreme; D011480:Protease Inhibitors; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
Chlorhexidine; Clinical trial; Composite resins; Dentine bonding agents; Non-carious cervical lesions; Restorative dentistry