Evaluation of the Groningen Frailty Indicator and the G8 questionnaire as screening tools for frailty in older patients with cancer.
OBJECTIVE
In this study, we evaluated the Groningen Frailty Indicator (GFI) and the G8 questionnaire as screening tools for a Comprehensive Geriatric Assessment (CGA) in older patients with cancer.


METHODS
Eligible patients with various types and stages of cancer were evaluated for frailty before treatment. Patients were categorized as patients with a normal CGA and abnormal CGA (≥2 impaired tests). The diagnostic performance of the screening tools was evaluated against the CGA with Receiver Operating Characteristic analysis.


RESULTS
In total, 170 patients (79 women) with median age 77years old (range 66-97years) were included. Sixty-four percent of patients had an abnormal CGA while according to the GFI (GFI≥4) and G8 questionnaire (G8≤14) 47% and 76% of patients had an abnormal screening test, respectively. Overall, there was no significant difference (p=0.97) in diagnostic performance between the two screening tools. The Area Under the Curve was 0.87 for both tools. For the GFI and G8 questionnaire the sensitivity was respectively 66% (95% CI: 56-75%), 92% (95% CI: 85-96%); the negative predictive value (NPV): 59% (95 CI%: 49-69%), 78% (95% CI: 63-88%); and the specificity: 87% (95% CI: 76-94%), 52% (95% CI: 39-65%).


CONCLUSIONS
In this study, we showed that overall both the GFI and the G8 questionnaire were able to separate older patients with cancer with a normal and abnormal CGA. For the G8 questionnaire, an adequate sensitivity and NPV were demonstrated, however at the expense of the specificity. For the GFI, we suggest to lower the threshold with one point to GFI ≥3 to screen patients for a CGA.
Department of Medical Oncology, Ziekenhuisnetwerk Antwerpen-Middelheim, Antwerp, Belgium. Electronic address: Abdelbari.Baitar@zna.be.
Abdelbari
A
Baitar
Frank
F
Van Fraeyenhove
An
A
Vandebroek
Els
E
De Droogh
Daniella
D
Galdermans
Jeroen
J
Mebis
Dirk
D
Schrijvers
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000592:standards*