Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: clinical findings.
The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the "gold standard" for the assessment of osteoporosis (T-score<-2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS's capability to detect osteoporosis in postmenopausal women.
Artann Laboratories, Trenton, NJ 08618, USA. Electronic address: vegorov@artannlabs.com.
Vladimir
V
Egorov
Artann Laboratories, Trenton, NJ 08618, USA.
Alexey
A
Tatarinov
Artann Laboratories, Trenton, NJ 08618, USA.
Noune
N
Sarvazyan
Artann Laboratories, Trenton, NJ 08618, USA.
Randee
R
Wood
Health Smart Medical Center, Philadelphia, PA 19115, USA.
Leonid
L
Magidenko
Mayo Clinic, Rochester, MN 55905, USA.
Shreyasee
S
Amin
Mayo Clinic, Rochester, MN 55905, USA.
Sundeep
S
Khosla
Catholic Health, Sisters of Charity Hospital, Buffalo, NY 14214, USA.
Richard J
RJ
Ruh
Catholic Health, Sisters of Charity Hospital, Buffalo, NY 14214, USA.
Jennifer M
JM
Ruh
Artann Laboratories, Trenton, NJ 08618, USA.
Armen
A
Sarvazyan
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging; D004867:Equipment Design; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000295:instrumentation*
Axial scanning; Bone quantitative ultrasound; Multi-frequency; Osteoporosis; Wave propagation parameters