Hyperactivity within an extensive cortical distribution associated with excessive sensitivity in error processing in unmedicated depression: a combined event-related potential and sLORETA study.
Individuals with depression are excessively sensitive to negative feedback and therefore overly cautious. To explore the neural mechanisms of response monitoring which contributed to their impaired behavioral adjustment, we recruited 22 individuals with depressive disorder and 24 healthy controls. Component analysis of the error-related negativity (ERN) and correct-related negativity (CRN), and sLORETA analysis of the ERN and CRN were combined. The comparable error rate and longer reaction time (RT) in individuals with depression as compared to healthy controls suggested a trade-off between accuracy and speed. The amplitude of the ERN and CRN was significantly enhanced in depression. Further sLORETA localizations of the ERN and CRN showed a significantly stronger current density with an extensive distribution in the anterior cingulate cortex (ACC), medial frontal cortex (MFC), inferior parietal lobule (IPL) and superior temporal gyrus (STG) in individuals with depression than in healthy controls. Increased activities in the ACC and MFC indexed increased response monitoring during automatic error detection, while hyperactivity over IPL and STG might indicate high uncertainness after error responses in depression. The hyperactivity within an extensive cortical distribution might be the neural basis of the excessive sensitivity to errors and the conservative accuracy/speed strategy in depression.
Department of EEG Source Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Yingying
Y
Tang
Xuanhong
X
Zhang
Molly
M
Simmonite
Hui
H
Li
Tianhong
T
Zhang
Qian
Q
Guo
Chunbo
C
Li
Yiru
Y
Fang
Yifeng
Y
Xu
Jijun
J
Wang
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003265:Contingent Negative Variation / Q000502:physiology; D003863:Depression / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004569:Electroencephalography; D055590:Electromagnetic Phenomena; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D014057:Tomography, X-Ray Computed
ACC; Anterior cingulate cortex; BA; Broadmann area; CRN; DLPFC; Depression; EEG; EOG; ERN/Ne; ERP; Error-related negativity; HAMD; Hamilton Rating Scale for Depression; ICD-10; IPL; Inferior parietal lobule; MDD; MFC; MINI; Medial frontal cortex; PFC; RT; STG; SnPM; Statistical non-Parametric Mapping; Superior temporal gyrus; anterior cingulate cortex; correct-related negativity; dorsolateral prefrontal cortex; electroencephalogram; electrooculography; error-related negativity; event-related potential; inferior parietal lobule; major depressive disorder; medial frontal cortex; prefrontal cortex; reaction time; sLORETA; standardized Low-Resolution Brain Electromagnetic Tomography; superior temporal gyrus; the Mini-International Neuropsychiatric Interview; the tenth revision of International Classification of Diseases