Bactericidal genes of Staphylococcal bacteriophage Sb-1.
Bacteriophage genes offer a potential resource for development of new antibiotics. Here, we identify at least six genes of Staphylococcus aureus phage Sb-1 that have bactericidal activity when expressed in Escherichia coli. Since the natural host is gram-positive, and E. coli is gram-negative, it is likely that a variety of quite different bacterial pathogens would be susceptible to each of these bactericidal activities, which therefore might serve as the basis for development of new wide-spectrum antibiotics. We show that two of these gene products target E. coli protein synthesis.
Ekaterine
E
Tevdoradze
Leila
L
Kvachadze
Mzia
M
Kutateladze
Charles R
CR
Stewart
D003001:Cloning, Molecular; D015870:Gene Expression; D005814:Genes, Viral; D050296:Microbial Viability / Q000235:genetics*; D014176:Protein Biosynthesis; D013204:Staphylococcus Phages / Q000235:genetics* / Q000378:metabolism; D013211:Staphylococcus aureus / Q000821:virology*