Effects of transcranial direct current stimulation on consolidation of fear memory.
It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm, in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal, and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 min after fear conditioning. The effect of fear conditioning and consolidation (24 h later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation.
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg , Würzburg , Germany.
Manish
M
Asthana
Katharina
K
Nueckel
Andreas
A
Mühlberger
Dorothea
D
Neueder
Thomas
T
Polak
Katharina
K
Domschke
Jürgen
J
Deckert
Martin J
MJ
Herrmann
dorsolateral prefrontal cortex; fear conditioning; fear memory consolidation; transcranial direct current stimulation