Membrane traffic: the exocyst meets the cell cycle.
A new study describes a novel regulatory event that results in the inhibition of exocytic transport of a specific class of Golgi-derived vesicles during mitosis. The mechanism of inhibition is shown to involve direct phosphorylation of a subunit of the exocyst by a specific cyclin-dependent kinase complex.
Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, 522 Taylor Hall, CB 7090, Chapel Hill, NC 27599-7090, USA. Electronic address: pjbrennw@med.unc.edu.
Patrick
P
Brennwald
D059447:Cell Cycle Checkpoints; D005089:Exocytosis; D008565:Membrane Proteins / Q000378:metabolism*; D008938:Mitosis; D012441:Saccharomyces cerevisiae / Q000166:cytology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins