Multicellular aggregation of maltol-modified cells triggered by Fe(3+) ions.
The synthesis of a maltol-derived hydrazide is described which, once attached to a cell surface, induces rapid multicellular aggregation selectively in the presence of Fe(3+) ions. Heterocellular aggregates are also reported.
Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. l.caggiano@bath.ac.uk.
Alexander
A
Ciupa
Paul A
PA
De Bank
Lorenzo
L
Caggiano
D000818:Animals; D002448:Cell Adhesion; D002449:Cell Aggregation / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D002614:Chelating Agents / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D007501:Iron / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*
D002614:Chelating Agents; D006834:Hydrazines; D011753:Pyrones; C029424:hydrazine; C008316:maltol; D007501:Iron