Hypercoagulability in a newborn with concomitant homozygous factor V Leiden and severe homozygous protein C deficiency type 1.
This is a case report of a female newborn presented with skin necrotic lesions 1 week after delivery. Laboratory investigations revealed severe homozygous protein C deficiency associated with homozygous factor V Leiden, although her pregnancy and perinatal periods were otherwise uneventful, with negative family history of thrombotic or bleeding disorders. Patient stabilization was established by supportive measures and long-term administration of fresh frozen plasma and warfarin.
Department of Hematology/Oncology, Queen Rania Al-Abdullah Hospital for Children, University of Jordan, Amman, Jordan.
Eman T
ET
Al Antary
Isam S
IS
Haddadin
Mufeed K
MK
Hamory
Maram M
MM
Daauuod
D025861:Blood Coagulation Disorders, Inherited / Q000097:blood*; D005165:Factor V / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D020151:Protein C Deficiency / Q000097:blood*; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood*
C095381:factor V Leiden; D005165:Factor V