Meniscus repair and regeneration: review on current methods and research potential.
Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cell-free scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patient-related treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.
Department of Biomedical Sciences for Health, University of Milan, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161, Milan, Italy.gperetti@iol.it.
Celeste
C
Scotti
Michael T
MT
Hirschmann
Pierluigi
P
Antinolfi
Ivan
I
Martin
Giuseppe M
GM
Peretti
D000818:Animals; D006801:Humans; D007592:Joint Diseases / Q000601:surgery / Q000628:therapy*; D008592:Menisci, Tibial / Q000473:pathology*; D045164:Mesenchymal Stem Cell Transplantation; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D023822:Tissue Engineering