GOMoDo: A GPCRs online modeling and docking webserver.
G-protein coupled receptors (GPCRs) are a superfamily of cell signaling membrane proteins that include >750 members in the human genome alone. They are the largest family of drug targets. The vast diversity and relevance of GPCRs contrasts with the paucity of structures available: only 21 unique GPCR structures have been experimentally determined as of the beginning of 2013. User-friendly modeling and small molecule docking tools are thus in great demand. While both GPCR structural predictions and docking servers exist separately, with GOMoDo (GPCR Online Modeling and Docking), we provide a web server to seamlessly model GPCR structures and dock ligands to the models in a single consistent pipeline. GOMoDo can automatically perform template choice, homology modeling and either blind or information-driven docking by combining together proven, state of the art bioinformatic tools. The web server gives the user the possibility of guiding the whole procedure. The GOMoDo server is freely accessible at http://molsim.sci.univr.it/gomodo.
Department of Biotechnology, University of Verona, Ca' Vignal 1, Verona, Italy.
Massimo
M
Sandal
Tran Phuoc
TP
Duy
Matteo
M
Cona
Hoang
H
Zung
Paolo
P
Carloni
Francesco
F
Musiani
Alejandro
A
Giorgetti
D000322:Adrenergic Agonists / Q000737:chemistry*; D018674:Adrenergic Antagonists / Q000737:chemistry*; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008024:Ligands; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D011487:Protein Conformation; D018341:Receptors, Adrenergic, alpha-2 / Q000737:chemistry*; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry*; D012984:Software
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D008024:Ligands; D018341:Receptors, Adrenergic, alpha-2; D018343:Receptors, Adrenergic, beta-2