Benign subclinical syringomatous proliferations adjacent to a microcystic adnexal carcinoma: a tumor mimic with significant patient implications.
Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive, malignant cutaneous tumor with pilar and eccrine differentiation. Mohs micrographic surgery is the treatment of choice for this condition, but specific histological findings can complicate MAC removal and leave doubt as to whether the tumor has been completely removed. Here we describe the clinical and pathological characteristics of a case in which a patient with an MAC underwent multiple reexcisions because of the presence of benign subclinical syringomatous proliferations adjacent to the primary lesion. Our case raises awareness of syringomatous proliferation, a benign process histologically similar but behaviorally distinct from a primary MAC. This experience highlights the importance of continued communication between dermatopathologists and dermatologic surgeons in providing quality patient care.
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Markus D
MD
Boos
Rosalie
R
Elenitsas
John
J
Seykora
Michael S
MS
Lehrer
Christopher J
CJ
Miller
Joseph
J
Sobanko
D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology; D018280:Carcinoma, Skin Appendage / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D005546:Forehead / Q000473:pathology; D006801:Humans; D015580:Mohs Surgery; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery*; D012878:Skin Neoplasms / Q000453:epidemiology; D013544:Sweat Gland Neoplasms / Q000473:pathology / Q000601:surgery*; D013545:Sweat Glands / Q000473:pathology*