The association of increased stomach wall radiotracer uptake with prolonged use of omeprazole capsules on myocardial perfusion imaging (MPI) using 99mTc-sestamibi SPECT.
Myocardial perfusion imaging (MPI) is widely used in routine practice for diagnosis and risk stratification of coronary artery disease (CAD). Intense curvilinear activity in the stomach wall of a patient was seen on MPI raw data. This phenomenon was completely dissimilar to the familiar intraluminal gastric reflux of sestamibi. This observed activity could have resulted in false-positive or false-negative artifacts - and inaccurate diagnosis - of the inferior wall of the left ventricle after MPI processing. On further exploration, the current researchers found that the patient had a history of 10-year Omeprazole capsule consumption. The authors present this infrequent case of intense stomach uptake to stress the related clinical and diagnostic implications with the aim to stimulate acute awareness of possible, unexpected infringements on image quality that could potentially interfere with accurate interpretation of the data.
Golestan Research Center of Gastroenterology and Hepatology, (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran. javaaadi@wp.pl.
Hamid
H
Javadi
Sara
S
Jallalat
Shahriar
S
Semnani
Mehdi
M
Mogharrabi
Iraj
I
Nabipour
Seyed Masoud
SM
Tabib
Moloud
M
Abbaszadeh
Majid
M
Assadi
D016477:Artifacts; D001692:Biological Transport; D002214:Capsules; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D011849:Radioactive Tracers; D013270:Stomach / Q000000981:diagnostic imaging / Q000187:drug effects*; D017256:Technetium Tc 99m Sestamibi; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
D002214:Capsules; D011849:Radioactive Tracers; D017256:Technetium Tc 99m Sestamibi; D009853:Omeprazole