Recent advances in enzymatic and chemical deracemisation of racemic compounds.
Deracemisation of racemic compounds is still the most important strategy to produce optically pure compounds despite many recent advances in asymmetric synthesis. Especially deracemisation approaches that give rise to single enantiomers are preferred, which can be achieved either by invoking organocatalysts, metal complexes or enzymes - leading to dynamic kinetic resolution - or by applying other deracemisation techniques based on stereoinversion or enantioconvergence. In this tutorial review, we will provide an overview of new, recently developed approaches that lead to the important goal of creating organic compounds of single chirality.
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. F.Rutjes@science.ru.nl.
Michał
M
Rachwalski
Niek
N
Vermue
Floris P J T
FP
Rutjes
D001419:Bacteria / Q000201:enzymology; D055162:Biocatalysis; D002384:Catalysis; D005658:Fungi / Q000201:enzymology; D008670:Metals / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D013237:Stereoisomerism
D008670:Metals; D009930:Organic Chemicals