First-trimester sonographic findings associated with a Dandy-Walker malformation and inferior vermian hypoplasia.
We report 2 cases in which first-trimester measurements of the intracranial translucency and the brain stem-to-occipital bone diameter were markedly enlarged. This finding was thought to represent an abnormal fourth ventricle-cisterna magna complex. Subsequently, the diagnoses of a Dandy-Walker malformation with partial vermian agenesis in 1 case and inferior vermian hypoplasia in the other were established and confirmed by either postmortem autopsy or postnatal magnetic resonance imaging. These cases suggest that evaluation of the fourth ventricle-cisterna magna complex, by measuring the intracranial translucency or brain stem-to-occipital bone diameter may identify some cases with structural malformations of the cerebellum as early as the first trimester.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Lenox Hill Hospital, North Shore-LIJ, 130 E 77th St, New York, NY 10075 USA. eranbor@yahoo.com.
Eran
E
Bornstein
José Luis
JL
Goncalves Rodríguez
Erika Carolina
EC
Álvarez Pavón
Héctor
H
Quiroga
Drorit
D
Or
Michael Y
MY
Divon
D002531:Cerebellum / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D003616:Dandy-Walker Syndrome / Q000000981:diagnostic imaging* / Q000196:embryology*; D004453:Echoencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*
Dandy-Walker malformation; inferior vermian hypoplasia; intracranial translucency; posterior fossa; prenatal diagnosis