Graphene oxide assisted synthesis of GaN nanostructures for reducing cell adhesion.
We report a general approach for the synthesis of large-scale gallium nitride (GaN) nanostructures by the graphene oxide (GO) assisted chemical vapor deposition (CVD) method. A modulation effect of GaN nanostructures on cell adhesion has been observed. The morphology of the GaN surface can be controlled by GO concentrations. This approach, which is based on the predictable choice of the ratio of GO to catalysts, can be readily extended to the synthesis of other materials with controllable nanostructures. Cell studies show that GaN nanostructures reduced cell adhesion significantly compared to GaN flat surfaces. The cell-repelling property is related to the nanostructure and surface wettability. These observations of the modulation effect on cell behaviors suggest new opportunities for novel GaN nanomaterial-based biomedical devices. We believe that potential applications will emerge in the biomedical and biotechnological fields.
CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China. yangr@nanoctr.cn wangch@nanoctr.cn.
Rong
R
Yang
Ying
Y
Zhang
Jingying
J
Li
Qiusen
Q
Han
Wei
W
Zhang
Chao
C
Lu
Yanlian
Y
Yang
Hongwei
H
Dong
Chen
C
Wang
D000818:Animals; D001792:Blood Platelets / Q000166:cytology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D005708:Gallium / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D010087:Oxides / Q000737:chemistry; D013499:Surface Properties
D010087:Oxides; C473348:gallium nitride; D006108:Graphite; D005708:Gallium