Photostable water-dispersible NIR-emitting CdTe/CdS/ZnS core-shell-shell quantum dots for high-resolution tumor targeting.
Near-infrared (NIR, 700-900 nm) fluorescent quantum dots are highly promising as NIR bioprobes for high-resolution and high-sensitivity bioimaging applications. In this article, we present a class of NIR-emitting CdTe/CdS/ZnS core-shell-shell quantum dots (QDs), which are directly prepared in aqueous phase via a facile microwave synthesis. Significantly, the prepared NIR-emitting QDs possess excellent aqueous dispersibility, strong photoluminescence, favorable biocompatibility, robust storage-, chemical-, and photo-stability, and finely tunable emission in the NIR range (700-800 nm). The QDs are readily functionalized with antibodies for use in immunofluorescent bioimaging, yielding highly spectrally and spatially resolved emission for in vitro and in vivo imaging. In comparison to the large size of 15-30 nm of the conventional NIR QDs, the extremely small size (≈ 4.2 nm or 7.5 nm measured by TEM or DLS, respectively) of our QDs offers great opportunities for high-efficiency and high-sensitivity targeted imaging in cells and animals.
Institute of Functional Nano and Soft Materials (FUNSOM) and Devices Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.
Jie
J
Wang
Yimei
Y
Lu
Fei
F
Peng
Yiling
Y
Zhong
Yanfeng
Y
Zhou
Xiangxu
X
Jiang
Yuanyuan
Y
Su
Yao
Y
He
D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging / Q000379:methods*; D045663:Quantum Dots / Q000737:chemistry; D012995:Solubility; D013440:Sulfides / Q000737:chemistry; D013691:Tellurium / Q000737:chemistry; D014867:Water / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
D019187:Cadmium Compounds; D013440:Sulfides; D017967:Zinc Compounds; C034939:cadmium sulfide; D014867:Water; C031238:zinc sulfide; D013691:Tellurium; C028337:cadmium telluride
Bioimaging; Core–shell–shell; In vitro and in vivo; Near infrared; Quantum dots