Myeloid-derived suppressor cells, age and cancer.
We have recently discovered that the levels of circulating myeloid-derived suppressor cells, which are associated with an impaired T-cell proliferation and produce high amounts of reactive oxygen species, increase with age and are elevated in individuals in remission from cancer. Herein, potential mechanisms underpinning these observations are discussed.
McMaster Immunology Research Centre & MG DeGroote Institute for Infectious Disease Research; McMaster University; West Hamilton, ON Canada.
Dawn Me
DM
Bowdish
age; immunosenescence; inflammation; myeloid derived suppressor cells; tumor