HIF-1α C1772T polymorphism and gastrointestinal tract cancer risk: a meta-analysis and meta-regression analysis.
OBJECTIVE
Recent evidence suggests that genetic variations in the hypoxia inducible factor-1α (HIF-1α) gene may have an impact on an individual's susceptibility to gastrointestinal tract (GIT) cancer; but individually published results are inconclusive. This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.


METHODS
An extensive literature search was conducted for appropriate articles published before May 1st, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratio with 95% confidence interval was calculated.


RESULTS
Six case-control studies were assessed with a total of 911 GIT cancer patients and 2774 healthy controls. Our meta-analysis indicated that the C variant of HIF-1α C1772T polymorphism appeared to confer an increased risk for GIT cancer. Further subgroup analyses indicated that the C variant of HIF-1α C1772T polymorphism may increase the risk of GIT cancer among Asian populations, but not among Caucasian populations. Univariate and multivariate meta-regression analyses confirmed that differences in ethnicity and cancer type are the major sources of heterogeneity. No publication bias was detected in this meta-analysis.


CONCLUSIONS
The current meta-analysis suggests that the C variant of HIF-1α C1772T polymorphism may increase the risk of GIT cancer, especially among Asian populations.
1 Department of General Surgery, Second Military Medical University , Shanghai, People's Republic of China .
Jian
J
Xu
Liang
L
Xu
Lintao
L
Li
Qing
Q
You
Luosi
L
Cha
D044466:Asian People; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D012307:Risk Factors; D044465:White People
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins