The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China.
BACKGROUND
The vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem-cell proliferation, and microbial defense.


OBJECTIVE
To evaluate the association between the VDR and psoriasis in the northeastern Chinese Han population.


METHODS
In this case-control study, 342 patients with psoriasis and 341 controls were genotyped for five common VDR gene polymorphisms (ApaI, TaqI, BsmI, FokI, and Cdx2) by the Multiplex SNapSHOT method.


RESULTS
The frequency of ApaI (rs7975232) allele A was significantly increased in psoriasis relative to the control group (27.8% vs. 22.1%, p=0.018); the allele A of the ApaI polymorphism showed a 1.35-fold increased risk of developing psoriasis. Haplotype analyses showed the BsmI/ApaI/TaqI/Cdx2/FokI GATGC to be significantly over-represented in psoriasis patients compared with controls (p=0.012). The BsmI/ApaI/TaqI haplotype GCT was presented to a lesser extent in psoriasis patients in comparison with control patients (72.2% vs. 77.9%, p=0.012).


CONCLUSIONS
These data suggest that VDR polymorphisms are associated with psoriasis in Northeastern Han Chinese population.
Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Xing
X
Zhou
Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Li-dan
LD
Xu
Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China. Electronic address: zhouxinghyd123@163.com.
Yu-zhen
YZ
Li
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000208:ethnology / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
D018167:Receptors, Calcitriol; C579457:VDR protein, human
Association study; Psoriasis; Single nucleotide polymorphism; Vitamin D receptor