Phyllodes tumor in survivors of childhood osteosarcoma: a single institution's experience.
We evaluate the incidence of second neoplasms in 86 patients with osteosarcoma (OS) of the extremities treated with different protocols of adjuvant chemotherapy. Three patients developed phyllodes tumors as the second neoplasm. One of these patients simultaneously developed a third cancer with therapy-related acute myeloid leukemia. The sites of primary OS were the tibia (2) and humerus (1). None had received prior radiotherapy before excision of phyllodes tumor. All the patients were female with a median age of 21.7 years at the time of presentation. As yet, that precise causation is unclear, but it can increase our understanding of carcinogenic processes, in general.
*Department of Pediatrics, Division of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University †Department of Internal Medicine, Division of Hematology/Oncology ‡Department of Orthopedic Surgery, Division of Joint Reconstruction §Department of Pathology, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Tang-Her
TH
Jaing
Chao-Ping
CP
Yang
Iou-Jih
IJ
Hung
Shih-Hsiang
SH
Chen
Tzung-Chih
TC
Tang
Hsin-Nung
HN
Shih
Chuen
C
Hsueh
D000293:Adolescent; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000628:therapy; D012516:Osteosarcoma / Q000453:epidemiology* / Q000628:therapy; D003557:Phyllodes Tumor / Q000453:epidemiology* / Q000628:therapy; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult