Pd-catalyzed cyclization and carbene migratory insertion: new approach to 3-vinylindoles and 3-vinylbenzofurans.
A Pd-catalyzed stereoselective synthesis of 3-vinylindoles and 3-vinylbenzofurans has been developed. The reaction merges the alkyne-based Pd-catalyzed cyclization and Pd carbene migratory insertion in a single catalytic cycle, generating a C-C single bond and a C═C double bond in one operation.
Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China, and State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.
Zhenxing
Z
Liu
Ying
Y
Xia
Shiyi
S
Zhou
Long
L
Wang
Yan
Y
Zhang
Jianbo
J
Wang