[Effect of acute exposure to high altitude on the pharmacokinetics of propranolol].
OBJECTIVE
To study the pharmacokinetics of propranolol in Wistar rats after acute exposure to high altitude.


METHODS
Fourteen male Wistar rats (200±20) g were selected. After administration of propranolol tablets (0.05 g/kg, i.g.), blood samples (3 mL) were collected at 0, 20, 40 min,1, 1.5, 2, 4, 6, 8, 12 and 24 h, respectively. The pharmacokinetic parameters were determined by LC-MS/MS and DAS 2.0 software.


RESULTS
The main pharmacokinetic area under concentration-time curve (AUC), mean retention time (MRT), half-life (t1/2) and peak plasma concentration (Cmax) of propranolol were increased by 442.61%, 47.45%, 73.13% and 352.97%, respectively, whereas Tmax and clearance (CL) were decreased by 80.87% and 68.94%, respectively.


CONCLUSIONS
This study displays significant changes in the pharmacokinetics of propranolol under high altitude, which may provide evidence for clinical rational application of propranolol at high altitude.
Key Laboratory of the Plateau of the Environmental Damage Control, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, China.
Wenbin
W
Li
Zhengping
Z
Jia
Hua
H
Xie
Juanhong
J
Zhang
Yanling
Y
Wang
Ying
Y
Hao
Rong
R
Wang
D000531:Altitude; D000818:Animals; D019540:Area Under Curve; D002853:Chromatography, Liquid; D008297:Male; D011433:Propranolol / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D053719:Tandem Mass Spectrometry
D011433:Propranolol