Cerebral organoids in a dish: progress and prospects.
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain development and disorders. In a recent issue of Nature, Lancaster et al. describe a new method for generating cerebral organoids in a dish and use it to model microcephaly.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, San Francisco, CA 94143, USA; University of California, San Francisco, San Francisco, CA 94143, USA.
Marina
M
Bershteyn
Arnold R
AR
Kriegstein
D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000473:pathology*; D006801:Humans; D008831:Microcephaly / Q000473:pathology*; D008954:Models, Biological; D009940:Organoids / Q000166:cytology* / Q000254:growth & development*; D046509:Tissue Culture Techniques / Q000379:methods*