Enantioselective synthesis of planar chiral ferrocenes via palladium-catalyzed annulation with diarylethynes.
When Boc-L-Val-OH was used as a ligand for the enantioselective Pd(II)-catalyzed annulation of N,N-substituted aminomethyl ferrocene derivatives with diarylethynes, ferrocenes with planar chirality could be achieved with excellent enantioselectivity (up to 99% ee).
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Yan-Chao
YC
Shi
Rong-Fei
RF
Yang
De-Wei
DW
Gao
Shu-Li
SL
You
C–H activation; annulation; asymmetric catalysis; ferrocene; palladium; planar chirality