[Vitamin D: skeletal and muscular effects].
Insufficient serum levels of 25-hydroxyvitamin D [25(OH)D] is a risk factor for osteoporosis. A new paradigm is emerging with the locally synthesized 1,25(OH)2D within osteoblasts and osteoclasts as the essential pathway for the effects of 25(OH)D in regulating bone remodeling via direct or indirect activation of the specific receptor VDR. Vitamin D has positive effects on fracture risk, muscular function and risk of falls; these effects are observed when serum levels of 25(OH)D are above 30 ng/ml (75 nmol/l). Vitamin D dosing interval may be relevant for reducing the risk of fracture, with evidence suggesting positive effects with short intervals of 3 months or less. It is recommended to maintain an optimal serum level of 25(OH)D when managing patients with osteoporosis or at risk of this bone disease.
CHU de Saint-Étienne, service de rhumatologie, Inserm U1059, 42055 Saint-Étienne, France. Electronic address: thierry.thomas@chu-st-etienne.fr.
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D000058:Accidental Falls / Q000706:statistics & numerical data; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D050723:Fractures, Bone / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D059352:Musculoskeletal Pain / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000378:metabolism
D014807:Vitamin D