Technologies: preclinical imaging for drug development.
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography (CT), ultrasound (US), positron emission tomography (PET) or single-photon emission computed tomography (SPECT) enable non-invasive measures of tissue structure, function or metabolism in vivo. The technologies can add value to preclinical studies by enabling dynamic pharmacological observations on the same animal and because of possibilities for relatively direct clinical translation. Potential benefits from the application of preclinical imaging should be considered routinely in drug development.
Paul M
PM
Matthews
Robert
R
Coatney
Hasan
H
Alsaid
Beat
B
Jucker
Sharon
S
Ashworth
Christine
C
Parker
Kumar
K
Changani
D000818:Animals; D003952:Diagnostic Imaging; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004358:Drug Therapy; D006801:Humans; D010599:Pharmacokinetics