The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes.
OBJECTIVE
Varicocele, most treatable pathologic condition in male infertility, exerts unfavorable effects on testicular ultrastructure via various mechanisms. In this study we aimed to demonstrate adverse effects of varicocele on both testes.


METHODS
Twenty one adult male Albino rats were divided into 3 groups. Sham operation was performed for group 1 (control group), and this group of rats were sacrificed 4 weeks later. Experimental varicocele model was performed for group 2 (varicocele group) and these animals were sacrificed 4 weeks after the operation. In group 3 the rats were varicocelectomized 4 weeks later. This group of rats were sacrificed at 4 weeks postoperatively. The level of testicular damage was examined, and serum testosterone and intratesticular testosterone levels were measured.


RESULTS
Mean (±SD) damage scores of the right testes of the sham, varicocele, and varicocelectomy groups were 0, 1.64 ± 1.3, and 1.21 ± 0.3, respectively. There was no statistically significant differences between damage scores of groups 2, and 3 (P = .320), relevant scores of both groups were determined to be significantly higher than group 1 (P = .009, and P = .001). Mean (±) damage scores of the left testes of the three groups were detected to be 0.43 ± 1.13, 2.29 ± 1.15, and 1.78 ± 0.39, respectively. The difference between varicocele, and varicocelectomy groups was not statistically significant (P = .112).


CONCLUSIONS
Unilateral varicocele has deleterious effects on both testes. There was no statistically significant difference as for histopathologic recovery following varicocelectomy.
Haydarpasa Numune Training and Research Hospital, Department of Urology, Istanbul, Turkey. drorhankoca@hotmail.com.
Metin Ishak
MI
Ozturk
Orhan
O
Koca
Muzaffer Oguz
MO
Keles
Gonca
G
Haklar
Ozgur
O
Baykan
Feriha
F
Ercan
Olgu Enis
OE
Tok
Muhammet Ihsan
MI
Karaman
D000818:Animals; D002452:Cell Count; D004195:Disease Models, Animal; D007985:Leydig Cells; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000737:chemistry* / Q000473:pathology*; D013739:Testosterone / Q000032:analysis*; D014646:Varicocele
D013739:Testosterone