Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification.
BACKGROUND
Liposarcomas are among the most common soft tissue sarcomas in adulthood.


OBJECTIVE
The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions.


METHODS
The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2.


METHODS
Chi-Square test was applied.


RESULTS
20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01).


CONCLUSIONS
p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.
Department of Pathology, Mustafa Kemal University, School of Medicine, Antakya/ Hatay, Turkey.
A
A
Arici
T
T
Ozgur
N
N
Ugras
U
U
Yalcinkaya
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D051736:Proto-Oncogene Proteins c-mdm2 / Q000032:analysis / Q000096:biosynthesis*; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*; D014944:World Health Organization
D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2