Low-cost label-free electrical detection of artificial DNA nanostructures using solution-processed oxide thin-film transistors.
A high-sensitivity, label-free method for detecting deoxyribonucleic acid (DNA) using solution-processed oxide thin-film transistors (TFTs) was developed. Double-crossover (DX) DNA nanostructures with different concentrations of divalent Cu ion (Cu(2+)) were immobilized on an In-Ga-Zn-O (IGZO) back-channel surface, which changed the electrical performance of the IGZO TFTs. The detection mechanism of the IGZO TFT-based DNA biosensor is attributed to electron trapping and electrostatic interactions caused by negatively charged phosphate groups on the DNA backbone. Furthermore, Cu(2+) in DX DNA nanostructures generates a current path when a gate bias is applied. The direct effect on the electrical response implies that solution-processed IGZO TFTs could be used to realize low-cost and high-sensitivity DNA biosensors.
School of Electrical and Electronic Engineering, Yonsei University , 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Si Joon
SJ
Kim
Joohye
J
Jung
Keun Woo
KW
Lee
Doo Hyun
DH
Yoon
Tae Soo
TS
Jung
Sreekantha Reddy
SR
Dugasani
Sung Ha
SH
Park
Hyun Jae
HJ
Kim
D015374:Biosensing Techniques; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification*; D005708:Gallium / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry
D003300:Copper; D004247:DNA; D005708:Gallium; D015034:Zinc Oxide