Dendritic cell migration through the lymphatic vasculature to lymph nodes.
The mobilization of antigen-presenting dendritic cells (DCs) from peripheral tissues to draining lymph nodes drives the initiation of adaptive immune responses. Recent advances have been made in understanding how and where DCs enter the lymphatic vasculature and what mechanisms control this process. In this chapter, we highlight these advances. Delineating DC-lymphatic vessel interactions is critical for our fundamental understanding of DC trafficking in states of health and disease and for efforts to manipulate DC mobilization for immunotherapy and vaccination.
Institute of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom.
Andrew M
AM
Platt
Gwendalyn J
GJ
Randolph
D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008198:Lymph Nodes / Q000166:cytology*; D042601:Lymphatic Vessels / Q000166:cytology*; D054400:Receptors, CCR7 / Q000378:metabolism
D054400:Receptors, CCR7
Adaptive immunity; Antigen presentation; Cell migration; Chemotaxis; Dendritic cell; Lymph node; Lymphatic vessel