Cushing syndrome.
Cushing syndrome is the constellation of signs and symptoms caused by protracted exposure to glucocorticoids. The most common cause of Cushing syndrome in children and adolescents is exogenous administration of glucocorticoids. Presenting features commonly include weight gain, growth retardation, hirsutism, obesity, striae, acne and hypertension. Almost invariably, linear growth is severely diminished, a factor which may be useful in differentiating between childhood obesity and Cushing syndrome. Diagnostic approaches are based on distinguishing between adrenocorticotropic hormone (ACTH)-dependent and ACTH-independent etiologies, and consideration of the most likely diagnosis by age. Treatment modality is dependent upon etiology. After cure, important components of care include attention to linear growth, pubertal progression and body composition.
Department of Pediatrics, Texas Tech University Health Sciences Center, 3601 - 4th Street, Mail Stop 9406, Lubbock, TX, 79430, USA.
Bibek
B
Bista
Nancy
N
Beck
D049913:ACTH-Secreting Pituitary Adenoma / Q000175:diagnosis / Q000628:therapy; D000236:Adenoma / Q000175:diagnosis / Q000628:therapy; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D001823:Body Composition; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005359:Fibrous Dysplasia, Polyostotic / Q000175:diagnosis; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D009765:Obesity / Q000175:diagnosis; D017591:Petrosal Sinus Sampling; D012463:Saliva / Q000737:chemistry
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone