Current and emerging challenges of field effect transistor based bio-sensing.
Field-effect-transistor (FET) based electrical signal transduction is an increasingly prevalent strategy for bio-sensing. This technique, often termed "Bio-FETs", provides an essentially label-free and real-time based bio-sensing platform effective for a variety of targets. This review highlights recent progress and challenges in the field. A special focus is on the comprehension of emerging nanotechnology-based approaches to facilitate signal-transduction and amplification. Some new targets of Bio-FETs and the future perspectives are also discussed.
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. miyahara.bsr@tmd.ac.jp.
Akira
A
Matsumoto
Yuji
Y
Miyahara
D000818:Animals; D015374:Biosensing Techniques; D002241:Carbohydrates / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D009865:Oocytes / Q000166:cytology / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D014173:Transistors, Electronic
D002241:Carbohydrates; D035683:MicroRNAs; D011506:Proteins; D004247:DNA