Analytical evaluation of urinary excretion of furosemide in barrows.
Market weight barrows were dosed with furosemide IM or orally, and urine (5 barrows) and blood (1 barrow) samples were collected. Extraction procedures and high-performance liquid chromatographic conditions were modified and adapted for analysis of porcine samples. Furosemide was cleared rapidly from plasma, but could be detected in urine 4 to 5 days after administration, using fluorescent or ultraviolet detection. Fluorescent detection was the preferred method for screening for furosemide. Approximately 12% of furosemide was excreted as the glucuronide conjugate.
Texas Veterinary Medical Diagnostic Laboratory, The Texas A&M University System, Drawer 3040, College Station, TX 77841-3040, USA.
A C
AC
Ray
T D
TD
Tanksley
D C
DC
LaRue
J C
JC
Reagor
D000818:Animals; D004232:Diuretics / Q000493:pharmacokinetics* / Q000652:urine*; D005665:Furosemide / Q000493:pharmacokinetics* / Q000652:urine*; D008297:Male; D013552:Swine / Q000652:urine*
D004232:Diuretics; D005665:Furosemide