Hematopoietic defects and iPSC disease modeling: lessons learned.
Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.
Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.
James M
JM
Kelley
George Q
GQ
Daley
D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D006402:Hematologic Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006454:Hemoglobins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D009154:Mutation / Q000235:genetics
D006454:Hemoglobins
Bone marrow failure; Disease modeling; Induced pluripotent stem cells; Reprogramming