Surfactant therapy for acute respiratory distress in children.
In children with acute lung injury the endogenous surfactant system is altered via a variety of different mechanisms, including inflammation, vascular dysfunction, oxidant injury, cellular injury and oedema. This article examines the pathophysiology of acute lung injury and surfactant use for treatment of acute respiratory failure in infants and children.
Department of Paediatrics, Paediatric Emergency and Intensive Care, Sapienza University of Rome, Rome, Italy. corrado.moretti@uniroma1.it
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C
Moretti
P
P
Papoff
C S
CS
Barbàra
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C
Liberati
M
M
Guidotti
F
F
Midulla
D055371:Acute Lung Injury / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002648:Child; D006801:Humans; D011663:Pulmonary Surfactants / Q000032:analysis / Q000627:therapeutic use*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*
D011663:Pulmonary Surfactants