[Expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma and their correlation with vasculogenic mimicry].
OBJECTIVE
To explore the expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma, their association with the clinicopathological factors and their roles in vasculogenic mimicry (VM) in the tumor.


METHODS
The expressions of CD133 and CD82/KAI1 and VM were detected by immunohistochemistry and histochemistry in 90 specimens of bladder urothelial carcinoma and 20 specimens of normal bladder epithelium tissue.


RESULTS
The positivity rates of CD133, CD82/KAI1 and VM in normal bladder epithelium tissue were 0, 90% and 0, showing significant differences from the rates of 65.6%, 31.1% and 31.1% in urothelial carcinoma, respectively (P<0.01). Positive expressions of CD133, CD82/KAI1 and VM were significantly correlated with pTNM stage and tumor relapse (P<0.01) but not with gender, age, or tumor numbers (P>0.05). CD133 expression was positively correlated with VM (P=0.487, P<0.05), and CD82/KAI1 expression was negatively correlated with VM (r=-0.452, P<0.01) and CD133 (r=-0.776, P<0.05).


CONCLUSIONS
The expressions of CD133 and CD82/KAI1 proteins are involved in the occurrence of VM in bladder urothelial carcinoma to contribute to the invasion and relapse of bladder carcinoma.
Department of Pathology, First Affiliated Hospital of Bengbu Medical College; Department of Pathology, Bengbu Medical College; Anhui Key Laboratory of Infection and Immunology, Bengbu 233030, China.E-mail: yulan790210@163.com.
Lan
L
Yu
Shiwu
S
Wu
Lei
L
Zhou
Wenqing
W
Song
Danna
D
Wang
D000071916:AC133 Antigen; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D002277:Carcinoma / Q000098:blood supply* / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D051861:Kangai-1 Protein / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000098:blood supply* / Q000378:metabolism*
D000071916:AC133 Antigen; D015703:Antigens, CD; C497688:CD82 protein, human; D006023:Glycoproteins; D051861:Kangai-1 Protein; C000606023:PROM1 protein, human; D010455:Peptides