Expression of growth hormone and growth hormone receptor in fibroadenomas of the breast.
Fibroadenoma is the most prevalent benign breast tumor. It consists of epithelial and stromal components. In general, breast tumors are highly hormonally dependent and growth hormone by its physiology may have a possible oncogenic potential. Therefore, the aim of this study was to determine the expression of growth hormone and growth hormone receptor in epithelial and stromal components of fibroadenomas. Study group included 30 randomly chosen fibroadenomas from female patients aged between 18 and 69 years. The expression of growth hormone and growth hormone receptor was defined in both histologic components of fibroadenomas. Growth hormone was expressed in 96.7% of both epithelial and stromal components of fibroadenomas, with stronger expression in the stromal component. The same percentage of positive reaction (96.7%) was obtained in the epithelial component of fibroadenomas for growth hormone receptor expression. Only 6.7% of stromal components tested for growth hormone receptor were positive. The high expression of growth hormone and growth hormone receptor in fibroadenoma tissue indicates their possible role in the pathogenesis of this tumor. Follow up of patients with high expression of growth hormone and growth hormone receptor may be suggested.
Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Tanja
T
Lenicek
Dino
D
Kasumović
Emil
E
Stajduhar
Tihana
T
Dzombeta
Zoran
Z
Jukić
Bozo
B
Kruslin
D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry*; D004848:Epithelium / Q000737:chemistry; D005260:Female; D018226:Fibroadenoma / Q000737:chemistry*; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011897:Random Allocation; D011986:Receptors, Somatotropin / Q000032:analysis*
D011986:Receptors, Somatotropin; D013006:Growth Hormone