Microbial biotransformation of 16α,17-epoxy-ent-kaurane-19-oic acid by Beauveria sulfurescens ATCC 7159-F.
Biotransformation of 16alpha,17-epoxy-ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7beta,17-dihydroxy-ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics.
SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, Arizona 85706-6800, USA.
Ricardo A
RA
Furtado
G M Kamal B
GM
Gunaherath
Jairo K
JK
Bastos
A A Leslie
AA
Gunatilak
D052982:Beauveria / Q000378:metabolism*; D001711:Biotransformation; D045786:Diterpenes, Kaurane / Q000378:metabolism*; D013237:Stereoisomerism
C584631:16alpha,17-epoxy-ent-kaurane-19-oic acid; D045786:Diterpenes, Kaurane