Electronegative LDL: a circulating modified LDL with a role in inflammation.
Electronegative low density lipoprotein (LDL(-)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(-) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(-) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(-) suggest that it could have a dual biological effect.
Servei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau, 167 Sant Antoni Maria Claret, 08025 Barcelona, Spain.
Montserrat
M
Estruch
José Luis
JL
Sánchez-Quesada
Jordi
J
Ordóñez Llanos
Sònia
S
Benítez
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D017209:Apoptosis; D050197:Atherosclerosis / Q000473:pathology; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000166:cytology; D008024:Ligands; D008070:Lipopolysaccharides / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000737:chemistry*; D009000:Monocytes / Q000166:cytology; D010100:Oxygen / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D008024:Ligands; D008070:Lipopolysaccharides; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D010100:Oxygen