What is the effect of pseudoexfoliation syndrome on renal function in patients without glaucoma?
OBJECTIVE
To evaluate renal function in patients with pseudoexfoliation syndrome.


METHODS
This prospective, cross-sectional, case-control study involved 49 patients with pseudoexfoliation syndrome (PEX) and 42 control subjects. Renal function was examined by biochemical parameters and Doppler ultrasonography. Serum creatinine, blood urea nitrogen, urea levels, urine microalbumin level and creatinine clearance were measured. Renal volume, resistive index and pulsatility index were calculated using Doppler ultrasonography.


RESULTS
The mean laboratory values for both groups were as follows: Creatinine, PEX: 0.81 ± 0.28 mg/dL - Control: 0.79 ± 0.22 mg/dL; urea, PEX: 31.6 ± 9.7 mg/dL - Control: 32.2 ± 8.4 mg/dL; blood urea nitrogen, PEX: 14.8 ± 4.6 mg/dL - Control: 15.1 ± 4.0 mg/dL; creatinine clearance, PEX: 89.1 ± 35.6 mL/min - Control: 99.0 ± 47.2 mL/min; microalbumin, PEX: 5.8 ± 22.7 mg/dL - Control: 2.7 ± 6.0 mg/dL. The differences between groups were not significant (p > 0.300). Renal volume, resistive index and pulsatility index values were similar in both groups (p > 0.200).


CONCLUSIONS
This study showed that pseudoexfoliation syndrome does not affect biochemical and ultrasonographic parameters associated with renal function.
Department of Ophthalmology .
Tansu
T
Gonen
Korcan Aysun
KA
Gonen
Savas
S
Guzel
D000368:Aged; D000369:Aged, 80 and over; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D017889:Exfoliation Syndrome / Q000503:physiopathology*; D005260:Female; D005901:Glaucoma / Q000503:physiopathology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism; D000075462:Serum Albumin, Human; D018608:Ultrasonography, Doppler
C422455:ALB protein, human; D012709:Serum Albumin; D003404:Creatinine; D000075462:Serum Albumin, Human