Long-term follow-up of Cushing's disease:a case report.
Cushing's disease is a condition in which hypercortisolism develops due to excessive hypophyseal adrenocorticotropic hormone production. It is rare in childhood. In this paper, we report the case of a 10-year-old male patient with hypophyseal microadenoma-related Cushing's disease who presented with obesity and was found to show poor height growth at follow-up. The diagnosis was confirmed with inferior petrosal sinus sampling, and the adenoma was successfully removed by transsphenoidal surgery. While adrenal axis suppression continued for approximately 1 year, clinical improvement was clearly observed after the third month following surgery. The findings in this patient demonstrate that decreased growth rate despite rapid weight gain in children can be early sign of Cushing's disease and emphasize the importance of monitoring of growth in obese children.
Sami Ulus Women Health, Children's Education and Research Hospital, Clinics of Pediatric Endocrinology, Ankara, Turkey. E-mail: veyselbas@yahoo.com.
Veysel Nijat
VN
Baş
Sebahat Yılmaz
SY
Ağladıoğlu
Aşan
A
Onder
Pınar
P
Ozışık
Havva Nur
HN
Peltek Kendirci
Semra
S
Cetinkaya
Zehra
Z
Aycan
D000236:Adenoma / Q000175:diagnosis* / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood; D002648:Child; D002940:Circadian Rhythm; D003907:Dexamethasone; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D017591:Petrosal Sinus Sampling; D047748:Pituitary ACTH Hypersecretion / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000601:surgery
D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone