Spontaneous methicillin-sensitive Staphylococcus aureus spondylodiscitis-Short course antibiotic therapy may be adequate: Evidence from a single centre cohort.
Spontaneous methicillin-sensitive Staphylococcus aureus spondylodiscitis is increasing in prevalence and there appears to be little consensus on the optimum management of this condition. This paper analyses antimicrobial therapy and associated outcomes over a seven-year period at a large UK hospital trust. A retrospective search strategy identified 55 patients; notes were available for 39. Patients were treated with a median 12 weeks of antibiotics (IQR 7), with 6 weeks intravenous (IQR 3) and 9 weeks oral therapy (IQR 6). 23 different treatment regimens were utilised. 33/36 (92%) patients for whom outcomes were available were cured or improved at latest follow-up. This study reports a wide variation in antibiotic prescribing at a single centre. Outcomes were generally positive regardless of total duration of therapy and proportion of intravenous therapy. These findings highlight the need for multi-centre prospective randomised controlled trials to determine the most clinically effective and low-risk treatment strategy.
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom. Electronic address: thom.locke@gmail.com.
Thomas
T
Locke
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.
Megan E
ME
Kell
Department of Neurosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.
Debapriya
D
Bhattacharyya
Department of Orthopaedics, Northern General Hospital, Herries Road, Sheffield S5 7AU, United Kingdom.
Ashley A
AA
Cole
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.
Ann L N
AL
Chapman
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D015299:Discitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D004358:Drug Therapy / Q000379:methods; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom
D000900:Anti-Bacterial Agents
Antibacterial agents; Methicillin-sensitive Staphylococcus aureus; Spondylodiscitis