Two new compounds from gorgonian-associated fungus Aspergillus sp.
One new gamma-lactone derivative 5-hydroxy-3-isopropyl-4-methoxyfuranone (1) and one new lactam derivative dehydrated-marinamide (2), along with two known compounds marinamide (3) and marinamide methyl ester (4) were isolated from the fermentation broth of the marine gorgonian-associated fungus Aspergillus sp. SCSGAF0093. Their structures were elucidated on the basis of spectroscopic and spectrometric analysis. Compound 1 showed significant toxicity to brine shrimp (Artemia salina) with a median lethal concentration (LC50) of 1.25 microM, and 3 inhibited protein tyrosine phosphatase 1B (PTP1B) with a half maximal inhibitory concentration (IC50) of 23.3 microg/mL.
Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
Xin-Ya
XY
Xu
Xiao-Yong
XY
Zhang
Fei
F
He
Jiang
J
Peng
Xu-Hua
XH
Nong
Shu-Hua
SH
Qi
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D001230:Aspergillus / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure
C584633:5-hydroxy-3-isopropyl-4-methoxyfuranone; D007769:Lactams; C584632:marinamide; D015107:4-Butyrolactone