Therapeutic and cosmetic applications of mangiferin: a patent review.
BACKGROUND
Mangiferin, a natural C-glucoside xanthone [2-C-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone], is abundantly present in young leaves and stem bark of the mango tree. The xanthonoid structure of mangiferin with C-glycosyl linkage and polyhydroxy components contributes to its free radical-scavenging ability, leading to a potent antioxidant effect as well as multiple biological activities.


METHODS
An extensive search was carried out to collect patent information on mangiferin and its derivatives using various patent databases spanning all priority years to date. The patents claiming therapeutic and cosmetic applications of mangiferin and its derivatives were analyzed in detail. The technology areas covered in this article include metabolic disorders, cosmeceuticals, multiple uses of the same compound, miscellaneous uses, infectious diseases, inflammation, cancer and autoimmune disorders, and neurological disorders.


CONCLUSIONS
Mangiferin has the potential to modulate multiple molecular targets including nuclear factor-kappa B (NF-κB) signaling and cyclooxygenase-2 (COX-2) protein expression. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities. The molecular structure of mangiferin fulfils the four Lipinski's requisites reported to favor high bioavailability by oral administration. There is no evidence of adverse side effects of mangiferin so far. Mangiferin could thus be a promising candidate for development of a multipotent drug.
CSIR Unit for Research and Development of Information Products , "Jopasana", 85/1, Paud Road, Kothrud, Pune 411 038 , India +91 9371161742 ; +91 20 25383558 ; manasit@urdip.res.in.
Manasi
M
Telang
Sivakami
S
Dhulap
Anita
A
Mandhare
Rajkumar
R
Hirwani
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D003358:Cosmetics / Q000737:chemistry*; D015195:Drug Design; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D031022:Mangifera / Q000737:chemistry; D010330:Patents as Topic; D015398:Signal Transduction / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D003358:Cosmetics; D016166:Free Radical Scavengers; D044004:Xanthones; C013592:mangiferin