Multifunctional MnO2 nanosheet-modified Fe3O4@SiO2/NaYF4:Yb, Er nanocomposites as novel drug carriers.
We report on a novel drug carrier which is based on the combination of magnetic and upconversion (UC) emission of Fe3O4@SiO2/NaYF4:Yb, Er (MSU) hybrids modified with MnO2 nanosheets (MSU/MnO2). The MSU hybrids were fabricated by covalently linking amino-modified Fe3O4@SiO2 particles with carboxyl-functionalized NaYF4:Yb, Er particles. The Fe3O4 core and the NaYF4:Yb, Er shell functioned successfully for magnetic targeting and fluorescence imaging, respectively. MnO2 nanosheets served as drug carriers and UC luminescence quenchers. The drug can be released by introducing glutathione (GSH) which reduces MnO2 to Mn(2+), and at the same time, UC luminescence can be turned on. These results clearly show that these MSU/MnO2 nanocomposites are promising platforms which can be applied to construct a smart drug delivery system with magnetic targeting and GSH-stimulation, as well as tracking by UC luminescence.
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. yhzhu@ecust.edu.cn.
Peng
P
Zhao
Yihua
Y
Zhu
Xiaoling
X
Yang
Jianhua
J
Shen
Xin
X
Jiang
Jie
J
Zong
Chunzhong
C
Li
D003224:Congo Red / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004871:Erbium / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D008163:Luminescent Measurements; D017895:Manganese Compounds / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
D004337:Drug Carriers; D017895:Manganese Compounds; D010087:Oxides; C525362:sodium yttriumtetrafluoride; D003224:Congo Red; D015019:Yttrium; C027424:manganese oxide; D012822:Silicon Dioxide; D004871:Erbium; D015018:Ytterbium; D005459:Fluorides; D052203:Ferrosoferric Oxide