Current acetylcholinesterase-inhibitors: a neuroinformatics perspective.
This review presents a concise update on the inhibitors of the neuroenzyme, acetylcholinesterase (AChE; EC 3.1.1.7). AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Molecular interactions (mode of binding to the target enzyme), clinical applications and limitations have been summarized for each of the inhibitors discussed. Traditional inhibitors (e.g. physostigmine, tacrine, donepezil, rivastigmine etc.) as well as novel inhibitors like various physostigmine-derivatives have been covered. This is followed by a short glimpse on inhibitors derived from nature (e.g. Huperzine A and B, Galangin). Also, a discussion on 'hybrid of pre-existing drugs' has been incorporated. Furthermore, current status of therapeutic applications of AChEinhibitors has also been summarized.
Sibhghatulla
S
Shaikh
Anupriya
A
Verma
Saimeen
S
Siddiqui
Syed S
SS
Ahmad
Syed M D
SM
Rizvi
Shazi
S
Shakil
Deboshree
D
Biswas
Divya
D
Singh
Mohmmad H
MH
Siddiqui
Shahnawaz
S
Shakil
Shams
S
Tabrez
Department of Bio-engineering, Integral University, Lucknow, 226026, India. shazibiotech@gmail.com.
Mohammad A
MA
Kamal
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000378:metabolism*; D019295:Computational Biology; D006801:Humans; D008958:Models, Molecular
D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase