Risk-adapted, dose escalation study of weekly docetaxel in the first-line treatment of elderly patients with advanced cancer.
OBJECTIVE
As a consequence of under-representation of elderly patients in clinical trials, the recommended dose of chemotherapy is often based on results observed in younger patients. We designed a risk-adapted, dose escalation study of weekly docetaxel in the first-line treatment of elderly patients with cancer in order to determine the optimal dose according to age, comorbidity and functional status.


METHODS
Sixty-eight patients aged 70 or more were stratified into three risk groups according to a combination of age, performance status, and comorbidity. The study was conducted using a standard phase I design with sequential cohorts of patients receiving docetaxel at increasing doses in each risk group.


RESULTS
The maximum tolerated dose was not reached in the intermediate-risk group and was 45mg/m(2)/week in the high-risk group. Because of a slow recruitment rate, it was not possible to conclude the trial in the good-risk category. Neutropenia, asthenia and diarrhea were the most frequently encountered severe toxicities.


CONCLUSIONS
Docetaxel can be used at a dose of 40mg/m(2)/week as a first-line treatment for elderly patients with locally advanced or metastatic cancer without excessive toxicity. The risk groups defined in the study are not able to accurately distinguish between subgroups of patients with divergent toxicity profiles.
Department of Medical Oncology, CRLC Val d'Aurelle, Montpellier, France. Electronic address: stephane.culine@sls.aphp.fr.
Stéphane
S
Culine
Catherine
C
Terret
Didier
D
Cupissol
Gilles
G
Romieu
Michel
M
Fabbro
Damien
D
Pouessel
Jean-Pierre
JP
Droz
Sophie
S
Gourgou
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015897:Comorbidity; D000077143:Docetaxel; D004305:Dose-Response Relationship, Drug; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D018570:Risk Assessment; D012720:Severity of Illness Index; D043823:Taxoids / Q000008:administration & dosage* / Q000009:adverse effects
D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel