Analgesic and anticonvulsant activities of some newly synthesized trisubstituted pyridine derivatives.
A series of novel pyridine carbohydrazide derivatives were synthesized from the reaction of 2-chloro-6-hydrazino-isonicotinic acid hydrazide with selected active reagents. All prepared compounds were tested as analgesic and anticonvulsant agents. The pharmacological screening showed that many of these compounds have good activities comparable to those of valdecoxib and carbamazepine as reference drugs.
Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
Osama I
OI
Abdel Salam
Mohamed A
MA
Al-Omar
Nagy M
NM
Khalifa
Abd El-Galil E
Ael-G
Amr
Mohamed M
MM
Abdallah
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*
D000700:Analgesics; D000927:Anticonvulsants; D011725:Pyridines; C023666:pyridine