For genomes to stay in shape, insulators must be up to PAR.
Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.
Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
Patrick J
PJ
Wijchers
Wouter
W
de Laat
D000818:Animals; D059006:Chromosomes, Insect / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D038101:Insulator Elements; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D011064:Poly Adenosine Diphosphate Ribose