Subsequent obstetrics outcomes after intrauterine death during the first pregnancy.
OBJECTIVE
We aimed to determine whether the risks of adverse outcomes were greater in women who had pregnancies ending in stillbirth than in those with no previous history of stillbirth.


METHODS
This retrospective cohort study included all women who had undergone their first and second deliveries at Bakirkoy Women's and Children's Education and Research Hospital between 2002 and 2011. Women who delivered following a previous stillbirth after 20 complete weeks of gestation were compared with those who had delivered but had no history of stillbirth after 20 weeks of gestation.


RESULTS
We compared 201 subsequent births to women with previous histories of stillbirth with 402 live births to women with no such history. The rates of pre-eclampsia [odds ratio (OR), 3.4; 95% confidence interval (CI), 1.5-7.4], HELLP syndrome (OR, 3.1; 95% CI, 1.2-9.6), low birth weight (OR, 1.6; 95% CI, 0.7-3.5) and malpresentation (OR, 2.9; 95% CI, 1.6-4.8) were significantly higher in the case group. Howewer, the rates of stillbirth were similar between the groups.


CONCLUSIONS
We found increased rates of obstetric and perinatal complications in subsequent pregnancies in women with histories of stillbirth. Thus, the results of this study suggest that pregnant women with histories of stillbirth should be followed closely, beginning in the early gestational period.
Department of Obstetrics and Gynecology, Kanuni Sultan Süleyman Teaching Hospital , İstanbul , Turkey .
Gökhan
G
Yildirim
Osman
O
Aşicioğlu
Kemal
K
Güngördük
Işıl
I
Turan
Deniz
D
Acar
Halil
H
Aslan
Taner
T
Günay
D000037:Abruptio Placentae / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D017359:HELLP Syndrome / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016015:Logistic Models; D015999:Multivariate Analysis; D007744:Obstetric Labor Complications / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D050497:Stillbirth
Obstetric and perinatal complications; stillbirth; subsequent pregnancy