Morphing methods to visualize coarse-grained protein dynamics.
Morphing was initially developed as a cinematic effect, where one image is seamlessly transformed into another image. The technique was widely adopted by biologists to visualize the transition between protein conformational states, generating an interpolated pathway from an initial to a final protein structure. Geometric morphing seeks to create visually suggestive movies that illustrate structural changes between conformations but do not necessarily represent a biologically relevant pathway, while minimum energy path (MEP) interpolations aim at describing the true transition state between the crystal structure minima in the energy landscape.
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Dahlia R
DR
Weiss
Patrice
P
Koehl
D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012984:Software; D013816:Thermodynamics
D011506:Proteins