Association between rs2981582 polymorphism in the FGFR2 gene and the risk of breast cancer in Mexican women.
OBJECTIVE
The rs2981582 single nucleotide polymorphism in the fibroblast growth factor receptor 2 gene has been consistently associated with an increased risk of breast cancer. We evaluated the effect of rs2981582 polymorphism in the FGFR2 gene on the risk of breast cancer and its interaction with non-genetic risk factors.


METHODS
A population-based case-control study was conducted in Mexico. Data from 687 cases and 907 controls were analyzed.


RESULTS
The T allele of the rs2981582 polymorphism was associated with an increased risk of breast cancer (ORper allele = 1.24, 95% CI 1.06-1.46). There was also an interaction between this polymorphism and alcohol consumption (p = 0.043). The effect of alcohol consumption on the risk of breast cancer varied according to the allelic variants of the rs2981582 polymorphism in the FGFR2 gene: OR = 3.97 (95% CI 2.10-7.49), OR = 2.01 (95% CI 1.23-3.29) and OR = 1.21 (95% CI 0.48-3.05) for genotypes CC, CT and TT, respectively.


CONCLUSIONS
This is the first study exploring the association between rs2981582 polymorphism in the FGFR2 gene and breast cancer risk in Mexican women. The interaction found may be of great public health interest because alcohol consumption is a modifiable breast cancer risk factor. Therefore, replication of this finding is of foremost importance.
Departamento de Epidemiología, Hospital No. 4, IMSS, Tecomán, Colima, Mexico.
Efrén
E
Murillo-Zamora
Hortensia
H
Moreno-Macías
Elad
E
Ziv
Isabelle
I
Romieu
Eduardo
E
Lazcano-Ponce
Angélica
A
Angeles-Llerenas
Edelmiro
E
Pérez-Rodríguez
Silvia
S
Vidal-Millán
Laura
L
Fejerman
Gabriela
G
Torres-Mejía
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010298:Parity; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D012923:Social Class
D051497:Receptor, Fibroblast Growth Factor, Type 2
Breast cancer; FGFR2 gene; rs2981582 single nucleotide polymorphism