Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
Department of Chemistry, The University of Iowa, Iowa City, IA 52242, United States.
Joseph J
JJ
Topczewski
Alexander M
AM
Lodge
Sumana N
SN
Yasapala
Maurice K
MK
Payne
Pedrom M
PM
Keshavarzi
Daniel M
DM
Quinn
D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism*; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology; D002619:Chemical Warfare Agents / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D011726:Pyridinium Compounds; D000110:Acetylcholinesterase
2-Methoxypyridinium compounds; Acetylcholinesterase; Reversible inhibition