Retinal asymmetry in children measured with optical coherence tomography.
OBJECTIVE
To determinate the physiological asymmetry of retinal measurements in the pediatric population with Fourier-domain optical coherence tomography (Cirrus HD-OCT).


METHODS
Prospective cross-sectional study.


METHODS
Three hundred and fifty-seven healthy children were recruited. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the retinal nerve fiber layer (RNFL), optic nerve head, and macula with Cirrus OCT. Differences between right and left eyes were calculated and values were compared by means of a paired t test. Normal ranges of interocular differences were established as the 2.5th and the 97.5th percentiles. The correlations between right and left eyes were assessed by the intraclass correlation coefficients.


RESULTS
Mean best-corrected visual acuity (logMAR) was -0.01. Differences in the average RNFL between right and left eyes were not statistically significant. The RNFL in the right eyes was thicker in the temporal and nasal quadrants, whereas the left eyes showed thicker RNFL in the superior quadrant. The interocular difference tolerance limits for average RNFL and macular thicknesses were 13.00 μm and 23.20 μm, respectively. There was a strong correlation for all the parameters between the right and the left eyes.


CONCLUSIONS
The asymmetry of retinal parameters might be more valuable than the absolute values in assessing certain early diseases. The interocular differences in average RNFL and macular thickness of normal individuals should not exceed 13 μm and 23 μm, respectively, if measured with Cirrus HD-OCT.
University of Zaragoza, Zaragoza, Spain; Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Irene
I
Altemir
Daniel
D
Oros
Noemi
N
Elía
Vicente
V
Polo
Jose M
JM
Larrosa
Victoria
V
Pueyo
D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D009929:Organ Size; D011446:Prospective Studies; D012160:Retina / Q000033:anatomy & histology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity