DRESS syndrome in a child treated for toxoplasma retinochoroiditis.
Children treated for toxoplasma retinochoroiditis may experience a range of severe adverse drug responses. Drug reaction with eosinophilia and systemic symptoms syndrome is a life-threatening idiosyncratic drug reaction with a 10% mortality. We present a case of drug reaction with eosinophilia and systemic symptoms syndrome in a child on standard combination treatment with oral sulfadiazine, pyrimethamine, folinic acid, and steroids for toxoplasma retinochoroiditis. Early clinical recognition and appropriate treatment led to a complete recovery and no longterm sequelae. The parents of children during sulfadiazine treatment should be counseled on the potential significance of nonspecific illness.
Royal Berkshire Hospital NHS Foundation Trust, London Road, Reading, United Kingdom.
Imran H
IH
Yusuf
Prashant
P
Sahare
G Darius
GD
Hildebrand
D000293:Adolescent; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D002825:Chorioretinitis / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000009:adverse effects; D011739:Pyrimethamine / Q000009:adverse effects; D013256:Steroids / Q000009:adverse effects; D013411:Sulfadiazine / Q000009:adverse effects; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D013256:Steroids; D013411:Sulfadiazine; D002955:Leucovorin; D011739:Pyrimethamine