Hierarchically assembled DNA origami tubules with reconfigurable chirality.
The dynamic reconfiguration of a hierarchically assembled tubular structure is demonstrated using the DNA origami technique. Short cylindrical DNA origami monomers are synthesized and linked into elongated tubules, which can then be disassembled via toehold-mediated strand displacement. The disassembled subunits are subsequently linked into tubules of a different chirality. The reconfiguration is performed with the subunits carrying dumbbell hairpin DNA oligonucleotides or gold nanoparticles (AuNPs). The reconfiguration of higher order origami structures presented here is useful for constructing dynamic nanostructures that exceed the size limit of single DNA origami and may facilitate the study of molecular or particle interactions by tuning their relative distance and organization.
School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Haorong
H
Chen
Tae-Gon
TG
Cha
Jing
J
Pan
Jong Hyun
JH
Choi
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D006046:Gold; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D010316:Particle Size; D013696:Temperature
D006046:Gold; D004247:DNA