Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease.
HSV-1 infection of the central nervous system targets the same brain regions most affected in Alzheimer's disease (AD) and could play a pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients with mild AD (n = 83) and healthy controls (HC, n = 51); results were correlated with cortical grey matter (GM) volumes as analyzed by MRI. Seroprevalence and antibody (Ab) titers were comparable between AD and HC; elevated Ab titers (>75th percentile) were nevertheless significantly more frequent in AD and were positively correlated with cortical bilateral temporal and orbitofrontal GM volumes. HSV-1-specific-Ab could possibly play a protective role in the early stages of AD.
Don Carlo Gnocchi Foundation, IRCCS, Milano, Italy.
Roberta
R
Mancuso
Francesca
F
Baglio
Monia
M
Cabinio
Elena
E
Calabrese
Ambra
A
Hernis
Raffaello
R
Nemni
Mario
M
Clerici
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D018259:Herpesvirus 1, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007074:Immunoglobulin G
Alzheimer's disease; HSV-1; humoral immunity; magnetic resonance imaging