[Preventive effect of ganlong capsule on chronic alcoholic hepatic injury in rats].
OBJECTIVE
To study the preventive effect of Ganlong capsule on chronic alcoholic hepatic injury in rats and its mechanism.


METHODS
The rat chronic hepatic injury model was induced by intragastrically administered with gradient alcohol, once a day for 12 weeks. Efforts were made to detect the content of ALT, AST, TG, CHO, TNF-alpha in rat serum and GSH, SOD, MDA, ADH, Alb in hepatic tissues were detected, conduct a hepatic pathological examination, and pathological injury grading for livers.


RESULTS
Ganlong capsule could reduce the content of ALT, AST, TG in blood serum, MDA in hepatic tissues (P < 0.05), and enhance the activities of antioxidants such as SOD and GSH in hepatic tissues (P < 0.05). According to the liver histopathological observation, most structures of hepatic lobules in the model group were destroyed, with disordered liver cell cords, diffuse fat empty bubbles of different sizes in cytoplasm, focal necrosis and infiltration of inflammatory cells. All of treatment groups showed alleviation in rat liver injury to varying degrees.


CONCLUSIONS
Ganlong capsule has a significant preventive effect to chronic alcoholic hepatic injury in rats.
Department of Foundation, Baoshan College of Traditional Chinese Medicine, Baoshan 678000, China. 550406648@qq.com
Xu-Qiang
XQ
Zhang
Hong-Bing
HB
Wu
Li
L
Peng
Xiao-Min
XM
Gong
Jiao
J
Li
Xiao-Fei
XF
Pu
Fang
F
Peng
D000818:Animals; D002214:Capsules; D002908:Chronic Disease; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D002214:Capsules; D014409:Tumor Necrosis Factor-alpha; D005978:Glutathione