Development of pulmonary arteries after a central end-to-side shunt in patients with pulmonary atresia, ventricular septal defect, and diminutive pulmonary arteries.
OBJECTIVE
To evaluate the development of pulmonary arteries (PAs) in patients with pulmonary atresia, ventricular septal defect, and diminutive PAs by using a central end-to-side shunt.


METHODS
A total of 103 consecutive patients (71 male and 32 female) with pulmonary atresia, ventricular septal defect, and diminutive PAs received a central end-to-side shunt between PA and aorta from May 2004 to December 2010. The age and weight ranged between 2 to 86 months and 2.5 to 21.5 kg, respectively. Overall 79 patients with main PA diameters less than 4 mm received a central end-to-side shunt between PA and aorta, and 24 patients with main PAs absence received a modified central shunt between PA branches and aorta.


RESULTS
There were no deaths during operation and follow-up. Compared with preoperative measures, total PA index increased from mean value 68.8 ± 11.4 mm2/m2 to 129.1 ± 24.9 mm2/m2 (p < 0.001). The increased PA index change at the time of 6 months or final repair after shunt completion was 87.7 ± 27.4% (27-150%). By multivariate regression analysis, age at shunt, shunt procedure, and number of major aortopulmonary collateral arteries were correlated with increasing PA index change.


CONCLUSIONS
The central end-to-side shunt promoted sufficient growth of the diminutive central PAs, especially in infant patients. Due to the risk of a distortion of pulmonary branches, the authors interposed a modified procedure for patients with main PAs absence by anastomosis of left PA and right PA directly in an end-to-side fashion to the both lateral wall of ascending aorta. It is technically easy to perform, warrants low risk of shunt thrombosis, and flow restriction in the early postoperative period.
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Minhua
M
Fang
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Huishan
H
Wang
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Yan
Y
Jin
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Zengwei
Z
Wang
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Zhenlong
Z
Wang
Department of Cardiovascular Surgery, Northern Hospital, Shenyang City, Liaoning Province, People's Republic of China.
Chunzhen
C
Zhang
D000015:Abnormalities, Multiple; D000714:Anastomosis, Surgical; D001011:Aorta / Q000503:physiopathology / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003097:Collateral Circulation; D005260:Female; D006343:Heart Septal Defects / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D010166:Palliative Care; D011651:Pulmonary Artery / Q000002:abnormalities / Q000254:growth & development / Q000503:physiopathology / Q000601:surgery*; D018633:Pulmonary Atresia / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011652:Pulmonary Circulation; D013997:Time Factors; D016896:Treatment Outcome; D066253:Vascular Remodeling