A longer waiting game: bridging children to heart transplant with the Berlin Heart EXCOR device--the United Kingdom experience.
BACKGROUND
Mechanical circulatory support (MCS) is used to support children with end-stage heart failure to heart transplant.


METHODS
This was a retrospective cohort study of 7 years' experience with the Berlin Heart (BH) EXCOR (Berlin Heart AG, Berlin Germany) paracorporeal ventricular assist device (VAD) in 2 United Kingdom (UK) pediatric heart transplant centers and the effect of this program on the UK pediatric heart transplant service.


RESULTS
Of 102 children who received BH support, 84% survived to transplant or BH explant and 81% survived to discharge. Neither age nor duration of support influenced outcome. Stroke, ongoing requirement for ventilation while on BH, and diagnosis other than dilated cardiomyopathy were the only independent mortality risk factors. Children who weighed < 20 kg had significantly (p = 0.03) longer support times than bigger children. The number of children treated with a BH increased over time (p = 0.01). Currently > 50% of pediatric heart transplants are bridged with a BH; however, pediatric transplants per year have not increased significantly (p = 0.07) CONCLUSIONS: BH use in the UK has allowed significant increases in the number of children with end-stage heart failure who can be successfully bridged to transplant and the length of time they can be supported. The total number of transplants has not increased.
Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, London, United Kingdom. Electronic address: ann.karimova@gosh.nhs.uk.
Jane
J
Cassidy
Troy
T
Dominguez
Simon
S
Haynes
Michael
M
Burch
Richard
R
Kirk
Aparna
A
Hoskote
Jon
J
Smith
Matthew
M
Fenton
Massimo
M
Griselli
Tain-Yen
TY
Hsia
Lee
L
Ferguson
Carin
C
Van Doorn
Asif
A
Hasan
Ann
A
Karimova
D000293:Adolescent; D001604:Berlin; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy*; D016027:Heart Transplantation; D006353:Heart-Assist Devices / Q000145:classification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology; D014850:Waiting Lists
Berlin Heart EXCOR; end stage heart failure; heart transplant; mechanical circulatory support; ventricular assist device