Molecular phenotype of primary mammary tumours and distant metastases in female dogs and cats.
Distant metastases represent a major step in the progression and fatal outcome of canine and feline mammary carcinomas. Recent studies have characterized the molecular phenotypes of mammary tumours and provided information on molecules that may allow targeted therapy in sites from which the tumours may not readily be surgically resected. Molecular phenotypes were determined immunohistochemically in three feline and two canine cases of mammary neoplasia, each presenting with multiple distant metastases. These tumours and their metastases often overexpressed the c-erbB-2 phenotype. A basal-like phenotype was found in the distant metastases from two cases. These findings suggest that canine and feline mammary tumours with distant metastases may be amenable to novel targeted therapies.
Department of Veterinary Medical Sciences, University of Bologna, Italy.
G
G
Beha
Department of Veterinary Medical Sciences, University of Bologna, Italy.
L V
LV
Muscatello
Department of Veterinary Medical Sciences, University of Bologna, Italy. Electronic address: b.brunetti@unibo.it.
B
B
Brunetti
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy.
P
P
Asproni
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy.
F
F
Millanta
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Italy.
A
A
Poli
Department of Veterinary Medical Sciences, University of Bologna, Italy.
C
C
Benazzi
Department of Veterinary Medical Sciences, University of Bologna, Italy.
G
G
Sarli
D000818:Animals; D002371:Cat Diseases / Q000378:metabolism* / Q000473:pathology; D002415:Cats; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000378:metabolism* / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology*; D010641:Phenotype; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D018719:Erb-b2 Receptor Tyrosine Kinases
cat; distant metastasis; dog; mammary tumour phenotype