pH-responsive gold nanoparticles-in-liposome hybrid nanostructures for enhanced systemic tumor delivery.
We report a pH-responsive gold nanoparticles-in-liposome hybrid nanostructure, which effectively combines the pH-responsive assembly and surface plasmon property changes of 'smart' gold nanoparticles and enhanced systemic circulation and tumor accumulation of the PEG-grafted liposomes.
Department of Chemistry, Pohang University of Science & Technology (POSTECH), San 31, Hyojadong, Namgu, Pohang 790-784, South Korea. Sungjee@postech.ac.kr.
Jutaek
J
Nam
Yeong Su
YS
Ha
Sekyu
S
Hwang
Woonghee
W
Lee
Jaejung
J
Song
Jeongsoo
J
Yoo
Sungjee
S
Kim
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D020349:Surface Plasmon Resonance; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D008081:Liposomes; D011092:Polyethylene Glycols; D006046:Gold