Regulation of tubulin glutamylation plays cell-specific roles in the function and stability of sensory cilia.
Microtubules (MTs) are post-translationally modified, but the functions of post-translational modifications (PTMs) have in many cases remained unknown. Most PTMs, such as polyglutamylation, occur on the protruding C-terminal tail (CTT) of tubulins, are reversible, and have been proposed to play a role in regulation of MT-associated proteins (MAPs), molecular motors, and MT-severing proteins. Several PTM enzymes have been identified, including a carboxypeptidase in mice known as CCP1, which reduces polyglutamylation on the CTT of MTs, and causes cell-specific neurodegeneration when mutated.
Department of Genetics; Rutgers; The State University of New Jersey; Piscataway, NJ USA.
Robert
R
O'Hagan
Maureen M
MM
Barr
CCP (cytosolic carboxypeptidase); TTLL (tubulin tyrosine ligase-like protein); axoneme; cilia; glutamylation; male-specific; microtubules; post-translational modification; sensory; tubulin