Comparative plasma exposure of albendazole after administration of rapidly disintegrating tablets in dogs.
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
Department of Pharmacy, Faculty of Chemical Sciences, UNITEFA, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina ; Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET, Argentina.
Silvina G
SG
Castro
Alicia
A
Dib
Gonzalo
G
Suarez
Daniel
D
Allemandi
Carlos
C
Lanusse
Sergio
S
Sanchez Bruni
Santiago D
SD
Palma
D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D005260:Female; D006244:Hardness; D013607:Tablets
D013607:Tablets; D015766:Albendazole