[Preparation, in vitro evaluation of excipient-free dry powder inhalation of extraction of Trollius chinensis].
To prepare and evaluate dry powder inhalation (DPI) of extraction of Trollius chinensis Bunge (TCB). Orthodox design was employed to optimize the parameters of spray drying to prepare micronized TCB powder, the DPI was prepared by mixing micronized TCB powder and lactose. The results showed that the fine particle fraction (FPF) and emitted dose (ED) of micronized TCB powder was (21.07 +/- 1.74)%, (75.31 +/- 21.05)%, respectively, and for DPI was (56.4 +/- 2.2)%, (95.9 +/- 3.0)%, respectively. Therefore, the prepared DPI meeted requirements in the Chinese Pharmacopeia, indicating a good application prospect.
College of Pharmaceutical Science, Suzhou University, Suzhou 215123, China. fangting_2008@126.com
Ting
T
Fan
Yun-Feng
YF
Zhu
Qing-Ri
QR
Cao
Jing-Hao
JH
Cui
D000280:Administration, Inhalation; D058995:Dry Powder Inhalers; D005079:Excipients; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D011208:Powders; D029626:Ranunculaceae
D005079:Excipients; D010936:Plant Extracts; D011208:Powders