Altered tissue electrical properties in women with breast cancer--preliminary observations.
OBJECTIVE
In the United States, breast cancer (BC) is the most common non-skin cancer. In Poland, it is estimated that the number of new breast cancer cases affects about 13,500 women each year. There are many methods for nutritional status assessment. One of them is bioimpedance analysis (BIA). Direct bioimpedance measures (resistance, reactance, phase angle (PA)) determined by bioelectrical impedance analysis (BIA) detectf changes in tissue electrical properties. The study was conducted to investigate whether there are any tissue electrical differences in patients with breast cancer.


METHODS
The direct bioimpedance measures determined by bioelectrical impedance analysis (BIA) were performed on 34 patients with BC and 34 healthy volunteers. The measurements were made with ImpediMed bioimpedance analysis SFB7 BioImp v1.55 (Pinkenba Qld 4008, Australia).


RESULTS
Reactance and resistance at 50 kHz was found to be significantly greater in patients with BC than in the control group (53.59° ± 1.53 vs. 47.26° ± 1.25, respectively, p=0.0031; 603.24° ± 15.38 ohm vs. 515.87° ± 11.48 ohm, respectively, p=0.00004).


CONCLUSIONS
Pre-surgical patients diagnosed with BC have altered tissue electrical properties. Further observations of a larger patient group would be valuable to calculate survival, validate the prognostic significance of PA, and monitor nutritional and therapeutic interventions in this patient population.
Department of Physiology, Medical University, Lublin, Poland.
Teresa
T
Małecka-Massalska
Krzysztof
K
Chara
Paweł
P
Gołębiowski
Magdalena
M
Władysiuk
Agata
A
Smoleń
Andrzej
A
Kurylcio
Beata
B
Zuchora
Jarosław
J
Zubrzycki
Grażyna
G
Orłowska-Kowalik
Krystyna
K
Lupa-Zatwarnicka
Wojciech
W
Polkowski
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D001834:Body Water / Q000502:physiology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004553:Electric Conductivity; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008875:Middle Aged; D011044:Poland; D018709:Statistics, Nonparametric