Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome.
BACKGROUND
The sticky platelet syndrome (SPS) is a common cause of thrombosis. There are no prospective studies concerning treatment.


OBJECTIVE
To analyze changes in platelet hyperaggregability of patients with SPS who were given antiplatelet drugs and to assess its association with rethrombosis.


METHODS
A total of 55 patients with a history of thrombosis and SPS phenotype were prospectively studied before and after treatment with aspirin and/or clopidogrel.


RESULTS
Patients were followed for 1 to 129 months, median 13. Of 55 patients, 40 received aspirin, 13 received aspirin + clopidogrel, and 2 received only clopidogrel. The platelet aggregation response to adenosine diphosphate and epinephrine significantly diminished after treatment, and only 2 patients developed rethrombosis 52 and 129 months after starting therapy, with the freedom from rethrombosis rate of the patients being 96.4% at 129 months.


CONCLUSIONS
Using antiplatelet drugs, the platelet hyperreactivity of patients with the SPS phenotype was reverted; and this translated into a substantial decrease in the rethrombosis rate.
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Santiago, Puebla, México.
Sara
S
Velázquez-Sánchez-de-Cima
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad de Las Américas Puebla, Cholula, Puebla, México.
Gabriela
G
Zamora-Ortiz
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad del Valle de México, Villahermosa, México.
Jesús
J
Hernández-Reyes
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Santiago, Puebla, México.
Jocelyn
J
Vargas-Espinosa
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Facultad de Medicina, Universidad de Las Américas Puebla, Cholula, Puebla, México.
Jessica
J
García-Chavez
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Facultad de Medicina, Universidad de Las Américas Puebla, Cholula, Puebla, México.
Jaime
J
Rosales-Padrón
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Santiago, Puebla, México.
Guillermo J
GJ
Ruiz-Delgado
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Santiago, Puebla, México.
Alejandro
A
Ruiz-Arguelles
Centro de Hematología y Medicina Interna de Puebla, Puebla, México Laboratorios Clínicos de Puebla, Díaz Ordaz 808, Puebla, México Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Santiago, Puebla, México Facultad de Medicina, Universidad de Las Américas Puebla, Cholula, Puebla, México gruiz1@clinicaruiz.com.
Guillermo J
GJ
Ruiz-Argüelles
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011446:Prospective Studies; D013577:Syndrome; D019851:Thrombophilia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D055815:Young Adult
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
aggregation; platelets; sticky platelet syndrome; thrombophilia; treatment