Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques.
This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.
Department of Biomedical Engineering, University of California-Davis, Davis, CA 95616, USA.
Hussain
H
Fatakdawala
Shannon
S
Poti
Feifei
F
Zhou
Yang
Y
Sun
Julien
J
Bec
Jing
J
Liu
Diego R
DR
Yankelevich
Steven P
SP
Tinling
Regina F
RF
Gandour-Edwards
D Gregory
DG
Farwell
Laura
L
Marcu
(170.3880) Medical and biological imaging; (170.5120) Photoacoustic imaging; (170.7180) Ultrasound diagnostics; (300.6500) Spectroscopy, time-resolved