[Experimental study on structure optimization of ginkgolide components].
Having searched a large number of literatures, the author found different concepts of traditional Chinese medicine components among pharmacists. Then, what are traditional Chinese medicine components? The author thinks that traditional Chinese medicine components shall be optimized traditional Chinese medicine components with relatively clear efficient substances, action mechanisms, specific purity and definite internal structure. This experiment preliminarily determined optimized component structures of ginkgolides by comparing the four reported constituents in in vivo and in vitro pharmacodynamic and pharmacological experiments. The experimental design could provide ideas and basis for optimizing traditional Chinese medicine components and determining their matching structures.
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. liudan0513@yeah.net
Dan
D
Liu
Xiao-Bin
XB
Jia
Wei
W
Xiao
D000818:Animals; D046934:Ginkgolides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008516:Medicine, Chinese Traditional; D051379:Mice; D012107:Research Design
D046934:Ginkgolides