Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure.
G proteins mediate signals from membrane G protein coupled receptors to the cell interior, evoking significant regulation of cell physiology. The cytoskeleton contributes to cell morphology, motility, division, and transport functions. This review will discuss the interplay between heterotrimeric G protein signaling and elements of the cytoskeleton. Also described and discussed will be the interplay between tubulin and G proteins that results in atypical modulation of signaling pathways and cytoskeletal dynamics. This will be extended to describe how tubulin and G proteins act in concert to influence various aspects of cellular behavior. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters.This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé.
Department of Physiology and Biophysics, University Of Illinois, Chicago, IL 60612, USA.
Jeffrey M
JM
Schappi
Department of Physiology and Biophysics, University Of Illinois, Chicago, IL 60612, USA; Jesse Brown VAMC, Chicago, IL 60612, USA.
Aleksandar
A
Krbanjevic
Department of Physiology and Biophysics, University Of Illinois, Chicago, IL 60612, USA; Department of Psychiatry, University Of Illinois, Chicago, IL 60612, USA. Electronic address: raz@uic.edu.
Mark M
MM
Rasenick
D000199:Actins / Q000378:metabolism*; D000818:Animals; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D014404:Tubulin / Q000378:metabolism*
D000199:Actins; D014404:Tubulin; D020962:Heterotrimeric GTP-Binding Proteins
Actin; Cytoskeleton; G protein; GPCR; Microtubule; Tubulin