Accessory subunits of mitochondrial complex I.
Mitochondrial complex I has a molecular mass of almost 1 MDa and comprises more than 40 polypeptides. Fourteen central subunits harbour the bioenergetic core functions. We are only beginning to understand the significance of the numerous accessory subunits. The present review addresses the role of accessory subunits for assembly, stability and regulation of complex I and for cellular functions not directly associated with redox-linked proton translocation.
*Medical School, Institute of Biochemistry II, Structural Bioenergetics Group, Cluster of Excellence Frankfurt 'Macromolecular Complexes', Goethe-University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt, Germany.
Katarzyna
K
Kmita
Volker
V
Zickermann
D042967:Electron Transport Complex I / Q000737:chemistry*; D004734:Energy Metabolism; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry*; D010084:Oxidation-Reduction; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000737:chemistry; D017494:Proton Pumps / Q000737:chemistry*; D011522:Protons
D046912:Multiprotein Complexes; D021122:Protein Subunits; D017494:Proton Pumps; D011522:Protons; D042967:Electron Transport Complex I