Circadian and circalunar clock interactions in a marine annelid.
Life is controlled by multiple rhythms. Although the interaction of the daily (circadian) clock with environmental stimuli, such as light, is well documented, its relationship to endogenous clocks with other periods is little understood. We establish that the marine worm Platynereis dumerilii possesses endogenous circadian and circalunar (monthly) clocks and characterize their interactions. The RNAs of likely core circadian oscillator genes localize to a distinct nucleus of the worm's forebrain. The worm's forebrain also harbors a circalunar clock entrained by nocturnal light. This monthly clock regulates maturation and persists even when circadian clock oscillations are disrupted by the inhibition of casein kinase 1δ/ε. Both circadian and circalunar clocks converge on the regulation of transcript levels. Furthermore, the circalunar clock changes the period and power of circadian behavior, although the period length of the daily transcriptional oscillations remains unaltered. We conclude that a second endogenous noncircadian clock can influence circadian clock function.
Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 9/4, 1030 Vienna, Austria; Research Platform "Marine Rhythms of Life," University of Vienna, Dr. Bohr-Gasse 9/4, 1030 Vienna, Austria.
Juliane
J
Zantke
Tomoko
T
Ishikawa-Fujiwara
Enrique
E
Arboleda
Claudia
C
Lohs
Katharina
K
Schipany
Natalia
N
Hallay
Andrew D
AD
Straw
Takeshi
T
Todo
Kristin
K
Tessmar-Raible
D000818:Animals; D000845:Annelida / Q000235:genetics / Q000502:physiology*; D057906:Circadian Clocks / Q000235:genetics / Q000502:physiology*; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D005260:Female; D008297:Male; D008969:Molecular Sequence Data