Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and lipotoxicity.
Fatty liver can be induced by obesity, some drugs and alcohol intoxication. In this liver lesion, lipid accumulation can involve only some hepatocytes but the significance of this cell-to-cell heterogeneity is unknown. In a recent work, Dr Pol et al. propose that high-fat hepatocytes could protect the cell population against oxidative stress and lipotoxicity.
INSERM, U991, Université de Rennes 1, 35000 Rennes, France. Electronic address: bernard.fromenty@inserm.fr.
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Fromenty
D000818:Animals; D022781:Hepatocytes / Q000166:cytology*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry*
D008055:Lipids
DAG; Diacylglycerol; FFA; Free fatty acid; LD; Lipid droplet; ROS; Reactive oxygen species; TAG; Triacylglycerol; WAT; White adipose tissue