Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report.
BACKGROUND
Granulosa cell tumors (GCT) are malignant tumors of the sex cord stroma representing 5% of all malignant ovarian tumors. Their treatment is surgery, and rarely chemotherapy and radiotherapy. Recently, salvage treatment with aromatase inhibitors was suggested based on few reported clinical cases.


METHODS
We present the case of a 61-year-old woman with unresectable recurrent GCT of the right ovary treated with the aromatase inhibitor letrozole. Tumor mass and peritoneal carcinomatosis decreased in size allowing almost complete surgical resection. The patient remained in complete clinical remission for at least 24 months after surgery while under letrozole.


CONCLUSIONS
Aromatase inhibitors represent an innovative treatment for these rare and refractory tumors offering promising results while avoiding toxic and marginally active chemotherapeutic agents.
Saint Joseph Hospital, Raymond and Aida Najjar Medical Center, Beirut, Lebanon.
Hampig R
HR
Kourie
Joseph
J
Kattan
Joelle
J
Antoun
Fadi
F
Sleilaty
D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006106:Granulosa Cell Tumor / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D000077289:Letrozole; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011859:Radiography; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole