Cytotoxic oxepinochromenone and flavonoids from the flower buds of Rosa rugosa.
A new oxepinochromenone, rugosachromenone A (1), seven new flavonoids, rugosaflavonoids A-G (2-8), and 11 known compounds (9-19) were isolated from the flower buds of Rosa rugosa. Compound 1 is found from Nature for the first time. Compound 2 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cells with IC50 values of 2.2, 2.5, and 2.3 μM, respectively, and 3 was toxic to A549 and MCF7 cells with IC50 values of 1.2 and 2.8 μM, respectively.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
Qiu-Fen
QF
Hu
Bin
B
Zhou
Jian-Ming
JM
Huang
Zhi-Yong
ZY
Jiang
Xiang-Zhong
XZ
Huang
Li-Ying
LY
Yang
Xue-Mei
XM
Gao
Guang-Yu
GY
Yang
Chun-Tao
CT
Che
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027826:Rosa / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C585237:rugosachromenone A