Prognostic significance of serum microRNA-210 levels in nonsmall-cell lung cancer.
OBJECTIVE
To investigate the levels of microRNA-210 (miR-210) in the serum of patients with nonsmall-cell lung cancer (NSCLC) and to determine whether there was a correlation with the prognosis of NSCLC patients following cisplatin-based chemotherapy.


METHODS
Quantitative real-time reverse transcription-polymerase chain reaction was used to measure the serum levels of miR-210 in patients with NSCLC and healthy age-matched control subjects. Correlations between serum miR-210 levels and clinicopathological factors and prognosis were investigated.


RESULTS
Serum miR-210 was significantly upregulated in 60 patients with NSCLC compared with 30 healthy control subjects. Higher serum miR-210 levels were significantly correlated with the clinical stage and the presence of regional lymph node metastasis in patients with NSCLC. Serum miR-210 levels in patients that achieved a partial response following cisplatin-based chemotherapy were significantly lower than in patients with stable or progressive disease, and were similar to those in healthy control subjects.


CONCLUSIONS
These findings suggest that serum miR-210 levels might be a novel diagnostic and prognostic marker of NSCLC.
Department of Thoracic Surgery, The First Hospital, Jilin University, Changchun, Jilin Province, China.
Zhi-Hong
ZH
Li
Hong
H
Zhang
Zhi-Guang
ZG
Yang
Guo-Qiang
GQ
Wen
You-Bing
YB
Cui
Guo-Guang
GG
Shao
D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C543800:MIRN210 microRNA, human; D035683:MicroRNAs; D002945:Cisplatin
Nonsmall cell lung cancer; microRNA; microRNA-210; prognostic significance; serum