Microbiota regulation of inflammatory bowel disease and colorectal cancer.
The host and microbiota have evolved mechanisms for coexistence over millions of years. Accumulating evidence indicates that a dynamic mutualism between the host and the commensal microbiota has important implications for health, and microbial colonization contributes to the maintenance of intestinal immune homeostasis. However, alterations in communication between the mucosal immune system and gut microbial communities have been implicated as the core defect that leads to chronic intestinal inflammation and cancer development. We will discuss the recent progress on how gut microbiota regulates intestinal homeostasis and the pathogenesis of inflammatory bowel disease and colorectal cancer.
Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China. Electronic address: zhanjuliu@yahoo.com.
Zhanju
Z
Liu
Anthony T
AT
Cao
Yingzi
Y
Cong
D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D064307:Microbiota
Colorectal cancer; Inflammatory bowel disease; Innate cells; Microbiota; T cells; Toll-like receptor