Hemostatic efficacy of a traditional medicinal plant extract (Ankaferd Blood Stopper) in bleeding control.
The aim of this study is to assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS) on rats using a tail bleeding model. Wistar rats were randomized into 4 groups of 9 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. Without heparin pretreatment, ABS shortened hemostasis time by 1.57 minutes and reduced the amount of bleeding by 0.85 g. With heparin pretreatment, ABS shortened hemostasis time by 3.29 minutes and reduced the amount of bleeding by 1.32 g. The ABS was more effective than saline irrigation for treating tail tip bleeding in rats, with or without heparin pretreatment, while also using a compressive dressing.
Faculty of Medicine, Department of Emergency Medicine, Bezmialem Vakif University, Istanbul, Turkey osogut@bezmialem.edu.tr.
Ozgur
O
Sogut
Department of Emergency Medicine, Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey.
Mehmet Ozgur
MO
Erdogan
Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Recep Tayyip Erdogan University, Rize, Turkey.
Rustu
R
Kose
Faculty of Medicine, Department of Paediatric Surgery, Harran University, Sanliurfa, Turkey.
Mehmet Emin
ME
Boleken
Faculty of Medicine, Department of Emergency Medicine, Harran University, Sanliurfa, Turkey.
Halil
H
Kaya
Faculty of Medicine, Department of Emergency Medicine, Harran University, Sanliurfa, Turkey.
Mehmet Tahir
MT
Gokdemir
Faculty of Medicine, Department of General Surgery, Harran University, Sanliurfa, Turkey.
Abdullah
A
Ozgonul
Faculty of Medicine, Department of Otolaryngology-Head and Neck Surgery, Harran University, Sanliurfa, Turkey.
Ismail
I
Iynen
Faculty of Medicine, Department of Emergency Medicine, Harran University, Sanliurfa, Turkey.
Levent
L
Albayrak
Faculty of Medicine, Department of Emergency Medicine, Harran University, Sanliurfa, Turkey.
Mehmet Akif
MA
Dokuzoglu
D000818:Animals; D006470:Hemorrhage / Q000628:therapy*; D006490:Hemostatics / Q000627:therapeutic use*; D009779:Occlusive Dressings; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper
Ankaferd Blood Stopper; experimental; hemostasis; heparin sodium; tail bleeding