Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.
Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.
Division of Medical Oncology; Department of Internal Medicine; The Ohio State University; Columbus, OH USA.
Thomas A
TA
Mace
Mark
M
Bloomston
Gregory B
GB
Lesinski
IL-6; STAT3; immunosuppression; myeloid-derived suppressor cells; pancreatic cancer stellate cells