Rutin and quercetin show greater efficacy than nifedipin in ameliorating hemodynamic, redox, and metabolite imbalances in sodium chloride-induced hypertensive rats.
Rutin and quercetin were investigated for their effects on blood pressure and antioxidant defense system of rats fed with 8% sodium chloride-supplemented diet (high salt diet) for 6 weeks. Animals fed with high salt diet demonstrated an increase in systolic, diastolic, pulse, and mean arterial blood pressures (p < 0.05) as well as lipid peroxidation but decreases in the activities of antioxidant enzymes compared with control group. Groups post-treated with rutin and quercetin for 2 weeks showed significant reversals in the values of these indices compared with the group fed with only the high salt diet but not post-treated. The high salt diet also led to significant increase in serum glucose, urea, creatinine, triglycerides, low-density-lipoprotein, and total cholesterol concentrations. Treatment with rutin and quercetin ameliorated the effects of high salt diet on these biochemical indices. The reference standard, nifedipin was less effective than rutin and quercetin. The results of this study highlight the risk of high salt consumption on cardiovascular health and the potent antioxidant and antihypertensive property of rutin and quercetin.
Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria.
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Olaleye
Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria.
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Crown
Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria acakinmoladun@futa.edu.ng.
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Akinmoladun
Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, The Federal University of Technology, Akure, Nigeria.
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Akindahunsi
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D062186:Arterial Pressure / Q000187:drug effects*; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D011794:Quercetin / Q000494:pharmacology*; D017208:Rats, Wistar; D012431:Rutin / Q000494:pharmacology*; D017673:Sodium Chloride, Dietary; D013997:Time Factors
D000959:Antihypertensive Agents; D000975:Antioxidants; D015415:Biomarkers; D017673:Sodium Chloride, Dietary; D012431:Rutin; D011794:Quercetin; D009543:Nifedipine
Rutin; antihypertensive property; antioxidant; nifedipin; quercetin; salt-induced hypertension