Adult patients hospitalized for measles in France, in the 21st century.
BACKGROUND
An epidemic of measles broke out in France in 2008. We designed a retrospective study focusing on adults hospitalized for measles in 2010/2011.


METHODS
A case was any patient aged more than 15 years, hospitalized (September 2010 to September 2011) with a typical rash or a biological diagnosis. Data was collected with standardized questionnaires in participating hospitals.


RESULTS
Four hundred and sixty cases were reported: sex-ratio (M/F) = 0.93, median age 26 years (σ = 8.8). Twenty-nine cases were severe (6.5%), 27 of which hospitalized in an ICU. Three hundred and twelve (68%) cases had elevated serum transaminases (EST), 155 (34%) cases had pneumonia, 34 (7%) cases had elevated serum creatinine (ESC), four (0.9%) cases had elevated serum amylase and lipase (ESAL), and three (0.7%) cases had neurological symptoms. One hundred and four (23%) patients presented simultaneously with EST and pneumonia. One patient presenting with severe pneumonia died (0.2%). One hundred and ten (24%) patients received antibiotics during a median seven days.


CONCLUSIONS
Measles can present as various syndromes in adults and be responsible for a high burden during outbreaks. The immediate outcome is favorable in most patients. Long-term outcome needs further investigations to identify possible late complications.
Infectious Diseases, Joseph-Fourier University 1, CHU, 38043 Grenoble, France. Electronic address: jpstahl@chu-grenoble.fr.
J P
JP
Stahl
D
D
Salmon
F
F
Bruneel
E
E
Caumes
F
F
Freymuth
J P
JP
Bru
P
P
Morand
F
F
Roblot
J L
JL
Schmit
C
C
Strady
J F
JF
Timsit
C
C
Rabaud
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000681:Amylases / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D004196:Disease Outbreaks; D018792:Encephalitis, Viral / Q000097:blood / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008049:Lipase / Q000097:blood; D008297:Male; D008457:Measles / Q000097:blood / Q000453:epidemiology*; D008587:Meningitis, Viral / Q000097:blood / Q000453:epidemiology; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology; D012189:Retrospective Studies; D063189:Symptom Assessment; D055815:Young Adult
D015415:Biomarkers; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008049:Lipase; D000681:Amylases
Adult; Adultes; France; Measles; Outbreak; Pneumonia; Pneumonies; Rougeole; Transaminases; Épidémie