G1 compartmentalization and cell fate coordination.
Pauklin and Vallier show that, whereas early G1 is permissive for TGF-β-dependent endoderm differentiation, cyclin D restricts the activity of Smad2/3 in late G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells. These findings provide insight into how signaling, the cell cycle, and lineage specification are coordinated.
Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA. Electronic address: sdalton@uga.edu.
Stephen
S
Dalton
D002453:Cell Cycle; D002454:Cell Differentiation; D056741:Cyclin D / Q000378:metabolism*; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D015398:Signal Transduction
D056741:Cyclin D