Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD).
Bone morphogenetic proteins (BMPs) have diverse and important roles in the proliferation and differentiation of adult stem cells in our tissues. Especially, BMPs are well known to be the main inducers of bone formation, by facilitating both proliferation and differentiation of bone stem cells. Interestingly, in skin stem cells, BMPs repress their proliferation but are indispensable for the proper differentiation into several lineages of skin cells. Here, we tested whether BMP antagonists have an effect on the prevention of wrinkle formation. For this study we used an in vivo wrinkle-induced mouse model. As a positive control, retinoic acid, one of the top anti-wrinkle effectors, showed a 44% improvement compared to the non-treated control. Surprisingly, bone morphogenetic protein receptor 1a extracellular domain (BMPR1a-ECD) exhibited an anti-wrinkle effect which was 6-fold greater than that of retinoic acid. Our results indicate that BMP antagonists will be good targets for skin or hair diseases.
joint Center for Biosciences at Songdo Global University Campus, Incheon 406-840, Korea james.yang.jcb@gmail.com.
Byung-Hak
BH
Yoon
Yun-Hui
YH
Jeon
Byunghee
B
Hwang
Hyuknam
H
Kwon
Senyon
S
Choe
Zungyoon
Z
Yang
D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D005260:Female; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D023421:Models, Animal; D011347:Procollagen / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects; D051898:Smad1 Protein / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology; D014466:Ultraviolet Rays; D000099176:Noggin Protein
D055396:Bone Morphogenetic Protein 2; D052005:Bone Morphogenetic Protein Receptors, Type I; D002352:Carrier Proteins; D008081:Liposomes; D020781:Matrix Metalloproteinase 1; D011347:Procollagen; D011994:Recombinant Proteins; D051898:Smad1 Protein; D014212:Tretinoin; D000099176:Noggin Protein