Imaging tau deposits in vivo: progress in viewing more of the proteopathy picture.
In this issue of Neuron, Maruyama et al. (2013) demonstrate the binding of a new class of selective tau ligands, termed PBBs, to tau deposits in transgenic mice and in human subjects with normal cognition, Alzheimer's disease, or a corticobasal syndrome.
Departments of Radiology, Pharmacology and Biological Chemistry, and Pharmaceutical Sciences, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA. Electronic address: mathisca@upmc.edu.
Chester A
CA
Mathis
William E
WE
Klunk
D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D024801:Tauopathies / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins