Interpreting patient treatment response in analgesic clinical trials: implications for genotyping, phenotyping, and personalized pain treatment.
Departments of Anesthesiology and Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA Departments of Biostatistics and Computational Biology and Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA Department of Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA Competence Center for Methodology and Statistics, CRP Santé, Strassen, Luxembourg.
Robert H
RH
Dworkin
Michael P
MP
McDermott
John T
JT
Farrar
Alec B
AB
O'Connor
Stephen
S
Senn
D000700:Analgesics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D005838:Genotype; D006801:Humans; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D010641:Phenotype; D057285:Precision Medicine / Q000379:methods*; D016896:Treatment Outcome
D000700:Analgesics
Genotyping; Mechanism-based treatment; Phenotyping; Treatment response; Treatment-by-patient interaction