Outcomes of kidney allograft in recipients with kidney disease of unknown etiology.
The etiology of renal disease is important because the primary renal pathology may affect the outcomes of kidney allograft with respect to recurrence, rejection, and survival. However, for a significant number of patients who undergo kidney transplantation, the disease etiology is unknown. Here, allograft outcomes for patients with kidney disease of unknown etiology (UEK) at three affiliated Korean hospitals were identified. The incidence of biopsy-proven acute rejection (BPAR) for UEK was 22.9%, which was similar to the rates for diabetic nephropathy (DN, 24.4%) and IgA nephropathy (IgAN, 20.0%; p = 0.345). The cumulative incidence of post-transplant glomerulonephritis (PTGN) among patients with UEK was significantly lower than that among patients with IgAN (p < 0.001). Overall graft survival of the UEK group was superior to that of the DN group (hazards ratio 0.39, 95% confidence interval 0.17-0.92, p = 0.030). Preemptive transplantation for UEK significantly reduced the incidence of BPAR (preemptive vs. non-preemptive 9.6% vs. 30.3%, p = 0.001), but graft survival and recurrence were not affected by preemptive transplantation. The outcomes of kidney transplantation for patients with UEK were not inferior to those for patients with IgAN or DN. Preemptive kidney transplantation may be encouraged for UEK patients.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hyo Jin
HJ
Kim
Hyunsuk
H
Kim
Hyun Seop
HS
Cho
Jin Ho
JH
Hwang
In Mok
IM
Jung
Curie
C
Ahn
Jongwon
J
Ha
Yun Kyu
YK
Oh
Chun Soo
CS
Lim
Dong-Wan
DW
Chae
Yon Su
YS
Kim
Jung Pyo
JP
Lee
D000328:Adult; D064591:Allografts; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology*; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
graft outcomes; kidney transplantation; preemptive transplantation; unknown etiology kidney disease