Cu-catalyzed tandem reactions of fluorinated alkynes with sulfonyl azides en route to 2-trifluoromethylquinolines.
A novel method for the synthesis of 2-trifluoromethylquinolines via Cu-catalyzed tandem reactions was reported. A strong electronic effect was observed, but the steric effect was negligible.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. ymwu@mail.sioc.ac.cn.
Yajun
Y
Li
Lisi
L
Zhang
Li
L
Zhang
Yongming
Y
Wu
Yuefa
Y
Gong
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D011804:Quinolines / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D011804:Quinolines; D003300:Copper