Human parvovirus B19 infection leads to downregulation of thyroid, estrogen, and retinoid hormone receptor expression.
Erythrovirus B19 (B19V) is a member of the family Parvoviridae. Infection with B19V has been linked to a variety of diseases including erythroid, thyroid, neurological and autoimmune diseases. Here we show that infection of primary CD36+ cells with B19V coincides with downregulation of thyroid, retinoid, and estrogen hormone receptors. In addition we show changes in expression of a variety of related downstream signaling genes participating in cancer and cardiac-related diseases in B19V-infected erythroid primary cells.
Department of Psychiatry, College of Medicine, University of Florida, 1200 Newell Road, R1-136, Gainesville, FL 32610, USA; Department of Pediatrics, College of Medicine, University of Florida, 1200 Newell Road, R1-136, Gainesville, FL 32610, USA; Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1200 Newell Road, R1-136, Gainesville, FL 32610, USA. Electronic address: ignatovich@ufl.edu.
Igor V
IV
Ignatovich
Jacqueline A
JA
Hobbs
D018955:CD36 Antigens / Q000032:analysis; D002478:Cells, Cultured; D015536:Down-Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D023461:Myeloid Progenitor Cells / Q000737:chemistry / Q000821:virology*; D016732:Parvovirus B19, Human / Q000502:physiology*; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis*; D011988:Receptors, Thyroid Hormone / Q000096:biosynthesis*; D015398:Signal Transduction; D014779:Virus Replication
D018955:CD36 Antigens; D011960:Receptors, Estrogen; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone
Erythroid; Erythrovirus; Estrogen; Hormone; Hormone receptor; Nuclear receptor; Parvovirus; Retinoid; Thyroid