Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese workers.
The associations of serum arginase I with serum L-arginine, serum 3-nitrotyrosine, and fractional exhaled nitric oxide (FENO) were evaluated cross-sectionally in healthy Japanese workers. The serum median (minimum-maximum) levels of arginase I, 3-nitrotyrosine, and FENO in healthy people (n = 130) were 14.6 (0.94-108.1) ng/mL, 81.0 (0.27-298.6) pmol/mg protein, and 14.0 (5.0-110.0) parts per billion, respectively. Significant correlations of arginase I with FENO, L-arginine, 3-nitrotyrosine, and percent predicted forced expiratory volume in 1 s (FEV1 (% predicted)) were observed, and correlations of FENO with immunoglobulin E (IgE), NOx, arginase I, and sex and allergy were also observed. By multiple regression analysis, arginase I showed positive associations with FENO and 3-nitrotyrosine, and a negative association with L-arginine; and FENO showed positive associations with IgE and NO2(-) + NO3(-) (NOx), and a negative association with L-arginine, as well as an association with sex. Moreover, logistic regression analysis showed linear inverse associations of arginase I and 3-nitrotyrosine with L-arginine, and showed linear positive associations of FENO with IgE and NOx. It was concluded that serum arginase I might regulate serum L-arginine and 3-nitrotyrosine via L-arginine, and that IgE or NOx might regulate FENO in a healthy Japanese population.
Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
K
K
Ogino
D H
DH
Wang
M
M
Kubo
Y
Y
Obase
H
H
Setiawan
F
F
Yan
H
H
Takahashi
R
R
Zhang
Y
Y
Tsukiyama
J
J
Yoshida
Y
Y
Zou
D000293:Adolescent; D000328:Adult; D000368:Aged; D001119:Arginase / Q000097:blood*; D001120:Arginine / Q000097:blood*; D003430:Cross-Sectional Studies; D045853:Exhalation; D005260:Female; D005541:Forced Expiratory Volume; D064368:Healthy Volunteers; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007564:Japan; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
D009569:Nitric Oxide; C002744:3-nitrotyrosine; D007073:Immunoglobulin E; D014443:Tyrosine; D001120:Arginine; C574619:ARG1 protein, human; D001119:Arginase