Clinicopathological and extensive immunohistochemical study of a type II pleuropulmonary blastoma.
Pleuropulmonary blastoma (PPB) is a rare malignant dysontogenetic neoplasm primarily affecting younger children, even in newborns with an unfavorable outcome. PPB is histologically composed of a primitive, variably mixed blastematous and sarcomatous components, and exclusively subclassified as type I (purely cystic), type II (both cystic and solid elements) and type III (completely solid) by increasing histological evidence of malignancy. At present, well-documented cases or cases of truly precise presentation of either pathological or immunohistochemical findings in PPB are rare. The authors report one case of PPB in a 44-month-old child presenting as a solid and cystic mass with special emphasis on its radiological, histopathological and immunohistochemical aspects. The histological diagnosis was PPB, which would belong to the type II category.
Department of Pathology, Xijing Hospital, Fourth Military Medical University , Xi'an , China.
Lu
L
Yu
Hong
H
Cheng
Shou Jing
SJ
Yang
D014408:Biomarkers, Tumor / Q000032:analysis; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D018202:Pulmonary Blastoma / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor