Detecting the effect of Alzheimer's disease on everyday motion behavior.
BACKGROUND
Early detection of behavioral changes in Alzheimer's disease (AD) would help the design and implementation of specific interventions.


OBJECTIVE
The target of our investigation was to establish a correlation between diagnosis and unconstrained motion behavior in subjects without major clinical behavior impairments.


METHODS
We studied everyday motion behavior in 23 dyads with one partner suffering from AD dementia and one cognitively healthy partner in the subjects' home, employing ankle-mounted three-axes accelerometric sensors. We determined frequency features obtained from the signal envelopes computed by an envelope detector for the carrier band 0.5 Hz to 5 Hz. Based on these features, we employed quadratic discriminant analysis for building models discriminating between AD patients and healthy controls.


RESULTS
After leave-one-out cross-validation, the classification accuracy of motion features reached 91% and was superior to the classification accuracy based on the Cohen-Mansfield Agitation Inventory (CMAI). Motion features were significantly correlated with MMSE and CMAI scores.


CONCLUSIONS
Our findings suggest that changes of everyday behavior are detectable in accelerometric behavior protocols even in the absence of major clinical behavioral impairments in AD.
Department of Computer Science, University of Rostock, Rostock, Germany.
Thomas
T
Kirste
André
A
Hoffmeyer
Philipp
P
Koldrack
Alexandra
A
Bauer
Susanne
S
Schubert
Stefan
S
Schröder
Stefan
S
Teipel
D061725:Accelerometry; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D001526:Behavioral Symptoms / Q000175:diagnosis* / Q000209:etiology*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis* / Q000209:etiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D013223:Statistics as Topic
Actigraphy; Alzheimer's disease; Cohen-Mansfield Agitation Inventory; Fourier analysis; chronobiology phenomena; circadian rhythm disorders; discriminant analysis; linear models; principal component analysis; psychomotor agitation