Prospective randomized study for antibiotic prophylaxis in spine surgery: choice of drug, dosage, and timing.
METHODS
Prospective randomized study of antibiotic prophylaxis in elective spine surgery.


OBJECTIVE
The aim of this study was to compare the rate of postoperative surgical site infection for a single dose of two different generations of cephalosporin with different dosage and timing of the antibiotics.


BACKGROUND
Current recommendation for prophylaxis in elective spine surgery is up to 60 minutes prior to incision. No study has investigated between different generation of cephalosporin for prophylaxis in elective spine surgery with respect to choice, dosage and timing.


METHODS
This study was a prospective randomized study of 90 patients, assessed for the occurrence of surgical site infection (defined by the Centers for Disease Control and Prevention criteria) and other infections for up to 6 months after surgery. Demographic, surgical and further data were collected on subsequent operations, including hardware removal.


RESULTS
Mean age in our group was 47 years (range, 19-71 years). The male to female ratio was 49:41 and the average timing of administration of antibiotics was 77 minutes (range, 30-120 minutes). The average blood loss was 626 mL (range, 150-3,000 mL) with a mean duration of surgery for 3.2 hours (range, 1.5-6 hours). One case of superficial infection and one case of deep infection met the exclusion criteria.


CONCLUSIONS
Our results support the use of a single preoperative dose of antibiotics in instrumented and non-instrumented elective spine surgery up to one hour prior to incision. There was no difference in terms of occurrence of surgical site infection with respect to dosage, choice and timing of antibiotics.
Orthopedic Surgeon and Spine Surgeon, Rameshwaram Orthopedic and Spine Clinic, Patna, India.
Nishant
Kannan Karthick
KK
Kailash
P V
PV
Vijayraghavan
Antibiotic prophylaxis; Spine; Surgical site infection