The serum levels of adiponectin and leptin in mustard lung patients.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients.


METHODS
Thirty nonsmoker mustard lung patients in stable phase were enrolled into this study. Also, 30 COPD and 21 healthy participants were entered as control groups. Complete lung function tests were performed in the participants. The serum levels of adiponectin and leptin were measured in all groups.


RESULTS
There were no statistically significant differences in mean adiponectin and leptin levels among the groups (p = 0.38 and p = 0.35, respectively). There was a downward trend in leptin to adiponectin ratio from lower to higher stages of global initiative for chronic obstructive lung disease guidelines in mustard lung patients, which was not statistically significant (p = 0.8).


CONCLUSIONS
Our results showed that there is no difference in mean adipokine levels in stable mustard lung patients compared with control groups. There was a foot-point in the alterations of serum adipokines regarding the severity of COPD, which needs to be documented by larger sample group.
Endocrinology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
H
H
Rokni Yazdi
COPD Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran larish851@yahoo.com.
S M
SM
Lari
COPD Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
D
D
Attaran
Cancer Molecular Pathology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
H
H
Ayatollahi
COPD Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
A
A
Mohsenizadeh
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D002619:Chemical Warfare Agents / Q000506:poisoning*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009151:Mustard Gas / Q000506:poisoning*; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D012129:Respiratory Function Tests; D012720:Severity of Illness Index
C499918:ADIPOQ protein, human; D052242:Adiponectin; D002619:Chemical Warfare Agents; D020738:Leptin; D009151:Mustard Gas
Sulfur mustard; adiponectin; chronic obstructive pulmonary disease; leptin