Outcome of early breast cancer treated in an urban and a rural breast cancer unit in Germany.
BACKGROUND
Conflicting evidence has been published concerning survival disadvantages in the outcome of breast cancer patients in relationship to their residency in urban or rural communities.


METHODS
The primary aim of this study was to evaluate differences in patients and treatment characteristics between an urban and a rural breast cancer unit. Therefore, all early breast cancer patients treated consecutively between 1999 and 2007 in a rural and an urban breast cancer unit were included. Patient and tumor characteristics, treatment strategies, and guideline adherence were included to evaluate the prognoses of both populations.


RESULTS
Overall, data from 2,566 patients were included in this analysis. The 610 patients treated in the rural unit showed significantly more negative prognostic criteria than the 1,956 patients treated in the urban center. No differences were observed with respect to surgical and systemic treatment after adjustment for prognostic parameters. Adherence to national guidelines did not differ significantly between both settings and ranged between 78.0 and 95.6%. Furthermore, no differences regarding recurrence-free and overall survival were observed.


CONCLUSIONS
The stage-adjusted pattern of care was similar in 2 German breast care units in a rural region and an urban area. Nevertheless, an earlier diagnosis of breast cancer should be enforced in rural areas to avoid extended treatment burden.
Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssen-Stiftung/Knappschafts GmbH, Essen, Germany.
Florian
F
Heitz
Alexandra
A
Bender
Jana
J
Barinoff
Fatemeh
F
Lorenz-Salehi
Annette
A
Fisseler-Eckhoff
Alexander
A
Traut
Rita
R
Hils
Philipp
P
Harter
Uwe
U
Kullmer
Andreas
A
du Bois
D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D055088:Early Detection of Cancer / Q000401:mortality*; D005260:Female; D054625:Healthcare Disparities / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016522:Oncology Service, Hospital / Q000706:statistics & numerical data*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data*; D015996:Survival Rate; D016896:Treatment Outcome; D014505:Urban Population / Q000706:statistics & numerical data