Synthesis, characterization and in vitro screening on bacterial, fungal and malarial strain of piprazinyl cyano biphenyl based compounds.
A series of eight 4'-[4-(3-substituted phenyl-acryloyl)-piprazin-1-ylmethyl]-biphenyl-2-carbonitrile were synthesized using 4'-Bromomethyl-biphenyl-2-carbonitrile and 4-Acetyl piprazine as a starting material. Furthermore, there has been some additional work done investigating effects of these derivatives on biological activities on bacterial, fungal and malarial strain. Synthesized compounds were characterized using FTIR, (1)H NMR and (13)C NMR spectrometry. These compounds shows good antimalarial, antibacterial and antifungal activity. In fact some compounds are more potent than standard drug quinine and Ampicillin some are with comparable activity with Ampicillin and quinine.
Department of Applied Chemistry, S.V. National Institute of Technology, Ichchhanath, Surat 395007, Gujarat, India. Electronic address: maheshmalani.svnit@gmail.com.
Mahesh H
MH
Malani
Bharat Z
BZ
Dholakiya
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000962:Antimalarials; D001713:Biphenyl Compounds; D009570:Nitriles; C010574:biphenyl
1,3-dibromo-5,5-dimethylhydantoin; 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid; AIBN; Antibacterial; Antifungal; Antimalarial; DDH; DMF; DMSO; FTIR; Fourier transform infrared spectroscopy; HEPES; JSB; Jaswant–Singh–Bhattacherji; MDC; MTCC; NMR; RBCs; RPMI; Roswell Park Memorial Institute; TEA; TLC; TMS; azobis isobutyronitrile; di methyl sulphoxide; dichloro methane; dimethyl formamide; microbial type culture collection; nuclear magnetic resonance; red blood cell; tetramethylsilane; thin layer chromatography; triethyl amine