Pulse therapy in pemphigus: report of 11 cases.
In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesions to heal more rapidly. Neither treatment however prevented the recurrence of the disease. Amenorrhea, myelotoxicity and Stevens-Johnson syndrome were among the cyclophosphamide side effects. All the patients treated with prednisone experienced known side effects.
School of Medicine, Federal University of Rio de Janeiro.
Nurimar Conceição
NC
Fernandes
Mariana
M
Menezes
D000293:Adolescent; D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
D003879:Dermatologic Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D003520:Cyclophosphamide; D011241:Prednisone