Biotransformation of methylphenylacetonitriles by Brazilian marine fungal strain Aspergillus sydowii CBMAI 934: eco-friendly reactions.
This study reports the biotransformation of methylphenylacetonitriles by Brazilian marine filamentous fungus Aspergillus sydowii CBMAI 934 under eco-friendly reaction conditions. The phenylacetonitrile 1, 2-methylphenylacetonitrile 2, 3-methylphenylacetonitrile 3, and 4-methylphenylacetonitrile 4 were quantitatively biotransformed into 2-hydroxyphenylacetic 1a, 2-methylphenylacetic acid 2a, 3-methylphenylacetic acid 3a, and 4-methylphenylacetic acid 4a by enzymatic processes using whole cell as biocatalyst. The marine fungus A. sydowii CBMAI 934 is thus a promising biocatalyst for the preparation of important carboxylic acids under mild conditions (pH 7.5 and 32 °C) from nitrile compounds.
Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São-carlense, 400, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
Julieta Rangel
JR
de Oliveira
Mirna Helena Regali
MH
Seleghim
André Luiz Meleiro
AL
Porto
D000097:Acetonitriles / Q000378:metabolism*; D001230:Aspergillus / Q000145:classification* / Q000378:metabolism*; D001711:Biotransformation; D001938:Brazil; D002264:Carboxylic Acids / Q000302:isolation & purification* / Q000378:metabolism*; D055772:Green Chemistry Technology / Q000379:methods*; D006868:Hydrolysis; D012623:Seawater / Q000382:microbiology*; D013045:Species Specificity; D014871:Water Microbiology
D000097:Acetonitriles; D002264:Carboxylic Acids