Differences between generalized q-sampling imaging and diffusion tensor imaging in the preoperative visualization of the nerve fiber tracts within peritumoral edema in brain.
BACKGROUND
Diffusion tensor imaging (DTI) tractography enables the in vivo visualization of white matter tracts inside normal brain tissue, which provides the neurosurgeon important information to plan tumor resections. However, DTI is associated with restrictions in the resolution of crossing fibers in the vicinity of the tumor or in edema. We find that generalized q-sampling imaging (GQI) can overcome these difficulties and is advantageous over DTI for the tractography of the fiber bundle in peritumoral edema.


OBJECTIVE
To demonstrate the differences between GQI and DTI in the preoperative mapping of fiber tractography in peritumoral edema of cerebral tumors, and discuss the clinical application of GQI in neurosurgical planning.


METHODS
Five patients with brain tumors underwent 3-T magnetic resonance imaging scans, and the data were reconstructed by DTI and GQI. We adjusted the parameters and compared the differences between DTI and GQI in visualizing the fiber tracts in the peritumoral edema of cerebral tumors.


RESULTS
GQI and DTI showed substantial differences in displaying the nerve fibers in the edema surrounding the tumor. The GQI tractography method could fully display existing intact fibers in the edema, whereas the fiber tracts in edema displayed by DTI tractography were incomplete, missing, or ruptured.


CONCLUSIONS
GQI can visualize the tracts in the peritumoral edema of cerebral tumors better than DTI. Although GQI has many limitations, its future in the preoperative guidance of brain tumor lesions is promising.
*Department of Neurosurgery, the First Affiliated Hospital of China Medical University, Liaoning, People's Republic of China; ‡Department of Radiology, the First Affiliated Hospital of China Medical University, Liaoning, People's Republic of China; and §Department of Psychiatry, the First Affiliated Hospital of China Medical University, Liaoning, People's Republic of China.
Hongliang
H
Zhang
Yong
Y
Wang
Tao
T
Lu
Bo
B
Qiu
Yanqing
Y
Tang
Shaowu
S
Ou
Xinxin
X
Tie
Chuanqi
C
Sun
Ke
K
Xu
Yibao
Y
Wang
D000328:Adult; D000368:Aged; D016880:Anisotropy; D001929:Brain Edema / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology; D055815:Young Adult