Primary immunodeficiency diseases at reference and high-specialty hospitals in the state of Guanajuato, Mexico.
BACKGROUND
In general, primary immunodeficiency diseases (PIDs) are underdiagnosed in most countries. The objective of this study was to describe the frequency and clinical spectrum of PID in the most important tertiary hospitals in our region.


METHODS
An observational, cross-sectional, with retrospective chart, review study was conducted. A total of 26 patients were included and grouped according to the updated classification of PIDs.


RESULTS
PIDs spectra were as follows: predominantly antibody deficiency diseases were the most common category (65.38%), followed by other well-defined immunodeficiency syndromes (11.55%), congenital defects of phagocyte number and/or function (7.69%), complement deficiencies (3.85%), combined T- and B-cell immunodeficiencies (3.85%), and defects in innate immunity (3.85%). The mean time elapsed from the onset of symptoms to the reference and diagnosis by a tertiary hospital was of 4.65 ± 6.95 years.


CONCLUSIONS
Predominant antibody deficiency disease was the most common group of PIDs, agreeing with international reports. Awareness of underdiagnosis by physicians is crucial for a prompt diagnosis and treatment, which in turn should improve the quality of life among patients with PIDs.
Departamento de Inmunología, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130 San Carlos La Roncha, 37660 León, GTO, Mexico.
Eduardo
E
Guaní-Guerra
Ulises Noel
UN
García-Ramírez
Ana Isabel
AI
Jiménez-Romero
José Manuel
JM
Velázquez-Ávalos
Gabriela
G
Gallardo-Martínez
Francisco-Javier
FJ
Mendoza-Espinoza
D000293:Adolescent; D002648:Child; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008297:Male; D008800:Mexico / Q000453:epidemiology