Preventing type 2 diabetes, CVD, and mortality: surgical versus non-surgical weight loss strategies.
The burden of type 2 diabetes is increasing. The prevention of the disease, improvement of metabolic control, and more importantly reduction in mortality remain a challenge for primary care doctors, diabetologists, researchers and policymakers. In this article, the available literature is reviewed with a focus on recent developments. Comparison between medical and surgical interventions is performed using mainly head-to-head trials where possible. Weight loss surgery is effective for glycaemic control. The need for level 1 data with hard end points such as cardiovascular risk and mortality is highlighted, and the prospect of the combination of existing therapy options is emphasized.
Investigative Science, Imperial College London, London, UK, dpournaras@doctors.org.uk.
D J
DJ
Pournaras
C W
CW
le Roux
D000818:Animals; D050110:Bariatric Surgery / Q000379:methods; D001786:Blood Glucose / Q000502:physiology; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000517:prevention & control* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality* / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology*
D001786:Blood Glucose