Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization.
Biologically active 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones have been synthesized in an efficient and concise manner utilizing readily available 4-hydroxyquinolin-2(1H)-ones as the starting material. The key strategy relies on the construction of the pyrrole ring through the palladium catalyzed sequential cross-coupling reaction and cyclization process.
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China. zwang@cqu.edu.cn.
Zhiyong
Z
Wang
Xiaoxiao
X
Xing
Lijun
L
Xue
Fang
F
Gao
Ling
L
Fang
D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*
D015363:Quinolones; D010165:Palladium