Drug resistance in patients with leprosy in the United States.
Molecular drug susceptibility testing was performed on 39 US patients with leprosy. Of these, 2 had dapsone-resistant Mycobacterium leprae and 1 of these patients also had rifampin-resistant M. leprae. Even though antileprosy drug resistance occurs in this leprosy population, resistance does not appear to be a major problem.
Laboratory Research Branch.
Diana L
DL
Williams
Cheryl
C
Lewis
Felipe G
FG
Sandoval
Naoko
N
Robbins
Stephen
S
Keas
Thomas P
TP
Gillis
David M
DM
Scollard
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003622:Dapsone / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D007918:Leprosy / Q000382:microbiology*; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012293:Rifampin / Q000494:pharmacology; D017422:Sequence Analysis, DNA; D014481:United States
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D003622:Dapsone; D012293:Rifampin
United States; drug resistance; leprosy