Pseudokiller, qu'est-ce que c'est?
Necroptosis is mediated by engagement of RIP kinases and a downstream pseudokinase, MLKL. In this issue of Immunity, Murphy et al. (2013) show that it operates at or close to the final execution mechanism of the death process.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38139, USA. Electronic address: douglas.green@stjude.org.
Douglas R
DR
Green
D000818:Animals; D017209:Apoptosis; D011494:Protein Kinases / Q000378:metabolism*; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D048069:Tumor Necrosis Factors / Q000378:metabolism*
D048069:Tumor Necrosis Factors; C570694:MLKL protein, mouse; D011494:Protein Kinases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C485615:Ripk3 protein, mouse