Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: single-point and longitudinal assessments.
Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to controls (n=24). Anti-tubulin and D2 receptor antibodies assessed in serial samples from 12 PANDAS subjects obtained prior to a documented exacerbation, during the exacerbation (with or without a temporally associated streptococcal infection), and following the exacerbation, showed no evidence of antibody levels correlating with a clinical exacerbation. These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS.
Department of Neurology, Johns Hopkins University School of Medicine, 200N Wolfe St. Suite 2158, Baltimore, MD 21287, United States.
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Morris-Berry
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Pollard
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Gao
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Thompson
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Singer
D000293:Adolescent; D000906:Antibodies / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology; D002648:Child; D003851:Deoxyribonucleases / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D016884:Polyendocrinopathies, Autoimmune / Q000097:blood* / Q000150:complications / Q000276:immunology; D017448:Receptors, Dopamine D2 / Q000276:immunology*; D013301:Streptolysins / Q000276:immunology*; D005879:Tourette Syndrome / Q000097:blood* / Q000150:complications; D014404:Tubulin / Q000276:immunology*
D000906:Antibodies; D001426:Bacterial Proteins; D017448:Receptors, Dopamine D2; D013301:Streptolysins; D014404:Tubulin; C025964:streptolysin O; D003851:Deoxyribonucleases
Anti-neuronal antibodies; D2 receptor; PANDAS; Single-point and longitudinal; Tourette syndrome; Tubulin