Epstein-Barr virus and human herpesvirus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing.
Comprehensive virome analysis of RNA sequence (RNA-seq) data sets from 118 non-Hodgkin's B-cell lymphomas revealed a small subset that is positive for Epstein-Barr virus (EBV) or human herpesvirus 6B (HHV-6B), with one coinfection. EBV transcriptome analysis revealed expression of the latency genes RPMS1, LMP1, and LMP2, with one sample additionally showing a high level of early lytic expression and another sample showing a high level of EBNA2 expression. HHV-6B transcriptome analysis revealed that the majority of genes were transcribed.
Department of Pathology, Tulane University, New Orleans, Louisiana, USA.
Michael J
MJ
Strong
Tina
T
O'Grady
Zhen
Z
Lin
Guorong
G
Xu
Melody
M
Baddoo
Chris
C
Parsons
Kun
K
Zhang
Christopher M
CM
Taylor
Erik K
EK
Flemington
D015331:Cohort Studies; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000821:virology*; D019349:Roseolovirus Infections / Q000175:diagnosis / Q000821:virology*; D017423:Sequence Analysis, RNA; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins