Calcium-phosphate-coated oral implants promote osseointegration in osteoporosis.
Osteoporotic conditions are anticipated to affect the osseointegration of dental implants. This study aimed to evaluate the effect of a radiofrequent magnetron-sputtered calcium phosphate (CaP) coating on dental implant integration upon installment in the femoral condyles of both healthy and osteoporotic rats. At 8 weeks post-implantation, bone volume and histomorphometric bone area were lower around non-coated implants in osteoporotic rats compared with healthy rats. Interestingly, push-out tests revealed significantly enhanced implant fixation for CaP-coated compared with non-coated implants in both osteoporotic (i.e., 2.9-fold) and healthy rats (i.e., 1.5-fold), with similar implant fixation for CaP-coated implants in osteoporotic conditions compared with that of non-coated implants in healthy conditions. Further, the presence of a CaP coating significantly increased bone-to-implant contact compared with that in non-coated implants in both osteoporotic (i.e., 1.3-fold) and healthy rats (i.e., 1.4-fold). Sequential administration of fluorochrome labels showed significantly increased bone dynamics close to CaP-coated implants at 3 weeks of implantation in osteoporotic conditions and significantly decreased bone dynamics in osteoporotic compared with healthy conditions. In conclusion, analysis of the data obtained demonstrated that dental implant modification with a thin CaP coating effectively improves osseointegration in both healthy and osteoporotic conditions.
Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
H S
HS
Alghamdi
V M J I
VM
Cuijpers
J G C
JG
Wolke
J J J P
JJ
van den Beucken
J A
JA
Jansen
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D017267:Dental Prosthesis Design; D004195:Disease Models, Animal; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D005456:Fluorescent Dyes; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D055114:X-Ray Microtomography
D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D005456:Fluorescent Dyes; D017886:Durapatite; D014025:Titanium
animal models; calcium phosphates; dental implantation; dental implants; postmenopausal osteoporosis; wound healing