Epidural metastasis in chemoresistant Wilms' tumor with perilobar nephroblastomatosis.
An 8-year-old boy with vertebral and epidural metastases was diagnosed with Wilms' tumor associated with perilobar nephroblastomatosis (NB) based on histologic examination. During combined chemotherapy with vincristine, actinomycin D, doxorubicin, and cyclophosphamide (NWTS-3 J protocol), a rapid increase in tumor size was observed. The treatment was replaced with etoposide and carboplatin (JET regimen). A transient response was sustained for 5 months during this chemotherapy. However, regrowth of the tumor was observed and the patient died 11 months after the initial chemotherapy.
The Second Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
H
H
Kurosawa
H
H
Kurumada
E
E
Haga
K
K
Sugita
M
M
Eguchi
T
T
Furukawa
Y
Y
Kurosu
T
T
Fujiwara
J
J
Hata