Copper-catalyzed activation of α-amino peroxy and hydroxy intermediates to iminium ion precursor: an access to C4-substituted 3,4-dihydroquinazolines via oxidative cross coupling strategy.
A simple and straightforward approach to access C4-substituted-3,4-dihydroquinazolines has been achieved, where copper-catalyzed activation of α-amino peroxide and hydroxide intermediates to iminium ion precursors has been realized as an important step. Reactions of these intermediates with alkynes, indoles, pyrrole, and silylenol ether afforded the structurally diverse C4-substituted-3,4-dihydroquinazoline derivatives in good yields.
Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 607, India.
R Arun
RA
Kumar
G
G
Saidulu
Balasubramanian
B
Sridhar
Shiuh Tzung
ST
Liu
K Rajender
KR
Reddy
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry*
D000480:Alkynes; D003432:Cross-Linking Reagents; D007097:Imines; D007477:Ions; D010545:Peroxides; D011799:Quinazolines; D003300:Copper