Chicken IL-6 is a heat-shock gene.
The febrile response is elicited by pyrogenic cytokines including IL-6 in response to microorganism infections and diseases in vertebrates. Mammalian HSF1, which senses elevations in temperature, negatively regulates the response by suppressing pyrogenic cytokine expression. We here showed that HSF3, an avian ortholog of mammalian HSF1, directly binds to and activates IL-6 during heat shock in chicken cells. Other components of the febrile response mechanism, such as IL-1β and ATF3, were also differently regulated in mammalian and chicken cells. These results suggest that the febrile response is exacerbated by a feed-forward circuit composed of the HSF3-IL-6 pathway in birds.
Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 755-8505, Japan.
Ramachandran
R
Prakasam
Mitsuaki
M
Fujimoto
Ryosuke
R
Takii
Naoki
N
Hayashida
Eiichi
E
Takaki
Ke
K
Tan
Fangxu
F
Wu
Sachiye
S
Inouye
Akira
A
Nakai
D051700:Activating Transcription Factor 3 / Q000235:genetics / Q000378:metabolism; D000818:Animals; D030161:Avian Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002645:Chickens / Q000235:genetics* / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D018869:Heat-Shock Response / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D051700:Activating Transcription Factor 3; D030161:Avian Proteins; C095720:HSF3 protein, Gallus gallus; D006360:Heat-Shock Proteins; D015850:Interleukin-6; D015534:Trans-Activators
Fever; HSF; Heat shock; IL-6; Inflammation