Formation and functions of the corneocyte lipid envelope (CLE).
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA. Electronic address: eliasp@derm.ucsf.edu.
Peter M
PM
Elias
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria; Department of Dermatology, University of California, San Francisco, CA, USA.
Robert
R
Gruber
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Debra
D
Crumrine
Department of Ornithology & Mammals, California Academy of Sciences, San Francisco, CA, USA.
Gopinathan
G
Menon
Departments of Dermatology and Pediatrics, University of California, San Francisco, CA, USA.
Mary L
ML
Williams
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Joan S
JS
Wakefield
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Walter M
WM
Holleran
Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.
Yoshikazu
Y
Uchida
D000818:Animals; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids
D008055:Lipids
Acylceramide; Corneocyte lipid envelope; Essential fatty acid deficiency; Gaucher's disease; Neutral lipid storage disease; Refsum disease