A new nervogenic acid glycoside with pro-coagulant activity from Liparis nervosa.
In an effort to identify hemostatic components from Liparis nervosa (Thunb.) Lindl. using a bioactivity-guided fractionation approach, the n-BuOH extract was found to promote ADP-induced platelet aggregation and two compounds were isolated from the active extract. Compound 1 was a new nervogenic acid glycoside and the structure was elucidated as 3,5-bis(3-methyl-but-2-enyl)-4-O-[beta-D-xylopyranosyl-(1 -->2)-beta-D-glucopyranosyl]-benzoic acid by extensive spectroscopic measurements. Adenosine (2) was isolated from this plant for the first time. Compound 1 also showed good pro-coagulant activity in vitro.
College of Biological Industry, Chengdu University, Chengdu 610106, PR China. sq82802@hotmail.com
Qin
Q
Song
Qingyao
Q
Shou
Xiaojun
X
Goun
Fengzhen
F
Chen
Jing
J
Leng
Weifeng
W
Yang
D000818:Animals; D001565:Benzoates / Q000302:isolation & purification* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D029595:Orchidaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
C584636:3,5-bis(3-methyl-but-2-enyl)-4-O-(beta-D-xylopyranosyl-(1-2)-beta-D-glucopyranosyl)benzoic acid; D001565:Benzoates; D006027:Glycosides