Comparative antimicrobial efficacy of alcohol-based hand rub and conventional surgical scrub in a medical center.
BACKGROUND
Hand hygiene is the cornerstone of aseptic techniques to reduce surgical site infection. Conventional surgical scrub is effective for disinfecting a surgeon's hands. However, the compliance of conventional scrub may be hindered by skin damage, allergy, and time. Alcohol-based hand rub has a satisfactory antimicrobial effect, but mostly in laboratory settings. Our aim was to compare a conventional surgical scrub with an alcohol-based hand rub to evaluate antimicrobial efficacy.


METHODS
From June 1, 2010 to July 31, 2011, 128 healthcare workers were enrolled in the study. They used an alcohol-based hand rub or a conventional surgical scrub as preoperative hand antisepsis during their routine practice. Hand sampling for cultures were performed before and after operations. Positive culture plates were further processed for pathogen identification.


RESULTS
The culture positive rate of the alcohol-based hand rub was 6.2% before operations and 10.8% after operations. Both rates were lower than the conventional surgical scrub [47.6% before operations (p < 0.001) and 25.4% after operations (p = 0.03)]. The most identified pathogens were Gram-positive with coagulase-negative staphylococci being the major pathogen. Multivariate analysis showed that prior hand condition (p = 0.21) and type of surgery such as cardiovascular surgery (p = 0.12) were less relevant, but the alcohol-based hand rub was a significant protective factor for positive hand cultures.


CONCLUSIONS
The alcohol-based hand rub was more efficacious for surgical antisepsis and had sustained efficacy, compared to conventional surgical scrub. We suggest that alcohol-based hand rubs could be an alternative surgical antiseptic in the operative theater.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Ni-Jiin
NJ
Shen
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan.
Sung-Ching
SC
Pan
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: whsheng@ntu.edu.tw.
Wang-Huei
WH
Sheng
Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan.
Kwei-Lian
KL
Tien
Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan.
Mei-Ling
ML
Chen
Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan.
Shan-Chwen
SC
Chang
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine, National Taiwan University, College of Medicine, Taipei, Taiwan.
Yee-Chun
YC
Chen
D000438:Alcohols / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D004202:Disinfectants / Q000627:therapeutic use*; D006225:Hand / Q000382:microbiology*; D006235:Hand Disinfection / Q000379:methods*; D006761:Hospitals; D006801:Humans; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control; D016896:Treatment Outcome
D000438:Alcohols; D004202:Disinfectants
Alcohol-based hand rub; Surgical antisepsis; Surgical site infection