[Modulation of scoliotic spine growth in experimental animals using intelligent metal bars].
OBJECTIVE
To create an experimental structural scoliosis model in mice to evaluate the efficacy of shape-memory metals to gradually correct the deformity over time.


METHODS
Experimental scoliosis was generated in 3 week-old mice by means of a suture between the left scapula and pelvis for 8 weeks. They were then randomised into two groups: a control group, in which the suture was cut, and another, in those that also had a Nitinol straight memory-wire implant fixed to the column. Serial X-rays were performed to determine the efficacy of the Nitinol in the correction of the scoliosis. In a second time, the histological changes at apical vertical body level and the adjacent discs were evaluated pre- and post-correction.


RESULTS
A mean 81.5° kyphoscoliosis was gradually induced. In the control group, after cutting the suture, an initial reduction in the deformity was observed, but later it remained stable throughout the time (54° at two weeks). In the Nitinol group, a gradual reduction was observed in the scoliosis angle value, to a mean of 8.7° at two weeks. The curvature of the apical vertebral body and adjacent discs were partially corrected after two weeks of correcting the deformity.


CONCLUSIONS
This scoliosis model has demonstrated the efficacy of a straight Nitinol wire fixed to the spinal column in the gradual correction of kyphoscoliosis and in the changes in its adjacent structures.
Unidad de Raquis, Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz, Madrid, España. Electronic address: jm.sanchez.marquez@gmail.com.
J M
JM
Sánchez-Márquez
F J
FJ
Sánchez Pérez-Grueso
N
N
Fernández-Baíllo
E
E
Gil-Garay
S
S
Antuña-Antuña
D000818:Animals; D001864:Bone Wires; D004195:Disease Models, Animal; D004867:Equipment Design; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D012600:Scoliosis / Q000503:physiopathology / Q000601:surgery*; D013131:Spine / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology
Corrección escoliosis; Escoliosis experimental; Experimental scoliosis; Metales con memoria de forma; Scoliosis correction; Shape-memory metals