RETRACTED: Gastroprotection studies of Schiff base zinc (II) derivative complex against acute superficial hemorrhagic mucosal lesions in rats.
The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats.



The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.790×10(-5) M/kg) was used as a reference medicine. The pre-treatment with the zinc (II) complex (2.181×10(-5) and 4.362×10(-5) M/kg) protected the gastric mucosa similar to the reference control. They significantly increased the activity levels of nitric oxide, catalase, superoxide dismutase, glutathione and prostaglandin E2, and decreased the level of malondialdehyde. The histology assessments confirmed the protection through remarkable reduction of mucosal lesions and increased the production of gastric mucosa. Immunohistochemistry and western blot analysis indicated that the complex might induced Hsp70 up-regulation and Bax down-regulation. The complex moderately increased the gastroprotectiveness in fine fettle. The acute toxicity approved the non-toxic characteristic of the complex (<87.241×10(-5) M/kg).



The gastroprotective effect of the zinc (II) complex was mainly through its antioxidant activity, enzymatic stimulation of prostaglandins E2, and up-regulation of Hsp70. The gastric wall mucus was also a remarkable protective mechanism.
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ; Institute of Biological Science, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
Shahram
S
Golbabapour
Nura Suleiman
NS
Gwaram
Pouya
P
Hassandarvish
Maryam
M
Hajrezaie
Behnam
B
Kamalidehghan
Mahmood Ameen
MA
Abdulla
Hapipah Mohd
HM
Ali
A Hamid A
AH
Hadi
Nazia Abdul
NA
Majid
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000009:adverse effects / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012545:Schiff Bases; D013482:Superoxide Dismutase / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
D000975:Antioxidants; C494827:Bax protein, mouse; C494828:Bax protein, rat; D002492:Central Nervous System Depressants; D018840:HSP70 Heat-Shock Proteins; D012545:Schiff Bases; D051028:bcl-2-Associated X Protein; D009569:Nitric Oxide; D000431:Ethanol; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D015032:Zinc; D015232:Dinoprostone