Thermal potentiation of chemotherapy by magnetic nanoparticles.
Clinical studies have demonstrated the effectiveness of hyperthermia as an adjuvant for chemotherapy and radiotherapy. However, significant clinical challenges have been encountered, such as a broader spectrum of toxicity, lack of patient tolerance, temperature control and significant invasiveness. Hyperthermia induced by magnetic nanoparticles in high-frequency oscillating magnetic fields, commonly termed magnetic fluid hyperthermia, is a promising form of heat delivery in which thermal energy is supplied at the nanoscale to the tumor. This review discusses the mechanisms of heat dissipation of iron oxide-based magnetic nanoparticles, current methods and challenges to deliver heat in the clinic, and the current work related to the use of magnetic nanoparticles for the thermal-chemopotentiation of therapeutic drugs.
Department of Chemical Engineering, University of Puerto Rico, Mayaguez Campus, PO BOX 9000, Mayaguez, PR 00681, Puerto Rico. madeline@ece.uprm.edu.
Madeline
M
Torres-Lugo
Carlos
C
Rinaldi
D017024:Chemotherapy, Adjuvant / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D008962:Models, Theoretical; D009369:Neoplasms / Q000628:therapy*; D013696:Temperature
D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide