Procedures for Preparation and Radiolabeling of a 3-Fluoropyrrolidine-Containing FDDNP Analog.
A novel FDDNP analog, namely 1-[6-(3-fluoropyrrolidin-1-yl)-2-naphthyl]ethylidenemalononitrile, was synthesized to probe the influence of the applied structural changes at the donor-side of the molecule on tau protein aggregate binding. Reported is also a synthetic procedure, which can be directly applied to the preparation of the [18F]-radiolabeled compound.
Andrej
A
Fister
Jorge R
JR
Barrio
Andrej
A
Petrič