N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions.
A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represents a reasonable alternative to the previous reported protection procedures.
LCOA, Bioorganic Chemistry Group, Chemistry Department, Sciences Faculty, Badji Mokhtar-Annaba University, P.O. Box. 12, 23000 Annaba, Algeria.
Zinelaabine
Z
Cheraiet
Souad
S
Ouarna
Sihem
S
Hessainia
Malika
M
Berredjem
Nour-Eddine
NE
Aouf