Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder.
Our work was sought to investigate possible changes in peripheral levels of interleukin-1β (IL-1β) according to the diagnosis of major depression (MD) and bipolar disorder (BD) and in different mood episodes. This is a cross-sectional nested in a population-based study comparing 240 young adults (80 controls, 80 MD and 80 BD), balanced for age and gender. Serum levels of IL-1β were significantly higher in MD when compared to control or BD subjects. In addition, when divided by current mood episode, MD subjects in current depression presented higher IL-1β levels than controls. No differences in IL-1β levels were found between different episodes of BD (euthymic, depressed, mania or mixed). Moreover, the use of psychiatric medication was very low in our sample and not associated with changes in IL-1β levels. In conclusion, increased peripheral IL-1β might be a useful marker associated with a depressive episode in the context of MD.
Programa de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Brazil.
Rosana
R
Mota
Marta
M
Gazal
Bruna A
BA
Acosta
Pâmela B
PB
de Leon
Karen
K
Jansen
Ricardo T
RT
Pinheiro
Luciano D
LD
Souza
Ricardo A
RA
Silva
Jean P
JP
Oses
Luciana
L
Quevedo
Diogo R
DR
Lara
Gabriele
G
Ghisleni
Manuella P
MP
Kaster
D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000097:blood* / Q000503:physiopathology; D018672:Community Health Planning; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000097:blood* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
D053583:Interleukin-1beta
Bipolar disorder; Current episode; IL-1β; Major depression