[Vitamin D and kidney diseases].
Calcitriol and analogs inhibit renin-angiotensin system, which has a pivotal role in glomerular and tubulo-interstitial damages and proteinuria, and inhibit NF-κB activation which is known to play an important role in renal diseases by promoting inflammation and fibrogenesis. Vitamin D presents interesting pleiotropic effects for the CKD patient (reduction of mortality, antiproteinuric effect and anti-inflammatory properties). "Native" vitamin D (cholecalciferol or ergocalciferol) administration in these patients also decrease parathyroid hormone levels. Native vitamin D administration in CKD patients is safe and does not lead to increased risk of vascular calcification, despite the known hypercalcemic and hyperphosphoremic properties of the molecule in its active form. Native vitamin D administration is not associated with an increased risk of renal stones, at pharmacological doses and without important concomitant administration of calcium salts. In the field of renal transplantation, experimental studies show that vitamin D analogs have a protective role against acute rejection but clinical studies remain mainly observational.
CHU de Liège, service de chimie médicale, Liège, Belgique. Electronic address: Etienne.cavalier@chu.ulg.ac.be.
Étienne
É
Cavalier
Éric
É
Thervet
Marie
M
Courbebaisse
D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007674:Kidney Diseases / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D016030:Kidney Transplantation; D020347:Lithiasis / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism
D014807:Vitamin D