Bone marrow provides an environment that prevents suppression of therapeutic graft-vs.-tumor immunity by regulatory T cells.
Regulatory T cells (Tregs) can prevent graft-vs.-host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.
Center for Immunology of Infectious Diseases and Vaccines; Netherlands Institute for Health and the Environment (RIVM); Bilthoven, The Netherlands.
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bone marrow; graft-vs.-host disease; graft-vs.-tumor; lymphocyte infusion; regulatory T cell