A passerini-type condensation: a carboxylic acid-free approach for the synthesis of the α-acyloxycarboxamides.
A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.
Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran. a-shaabani@sbu.ac.ir.
Mojtaba
M
Mahyari
Shabnam
S
Shaabani
Ahmad
A
Shaabani
Seik Weng
SW
Ng
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy
D000577:Amides; D002264:Carboxylic Acids