Prepubertal bisphenol A exposure interferes with ovarian follicle development and its relevant gene expression.
Bisphenol A (BPA) is recognized as one of several environmental estrogens. Pre-puberty is an important part of reproductive system development, and even a short-term exposure to BPA during this period may cause serious damage to the reproductive system. In this study, Pre-puberty female Wistar rats were exposed to BPA for one week. The effects of BPA on ovarian structure and function were assessed. The expression levels of follicle development-related genes were analyzed. Our study showed that BPA reduced rat ovarian weights and follicle numbers, and interferes with the constituent ratio of follicles. With increasing doses of BPA, the expression of factor in the germline alpha (FIGLA) and oocyte-specific histone H1 variant (H1FOO) genes decreased, and anti-mullerian hormone (AMH) genes expression increased, suggesting that BPA exposure during the pre-pubertal period may inhibit the development of ovaries, and follicle development-related genes may play certain roles in this process.
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Yuchen
Y
Li
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China. Electronic address: wenchang2008@126.com.
Wenchang
W
Zhang
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Jin
J
Liu
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Wenxiang
W
Wang
Emergency Department, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China.
Hong
H
Li
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Jianling
J
Zhu
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Shaozheng
S
Weng
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Shihua
S
Xiao
Fujian Province Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
Tingting
T
Wu
D000818:Animals; D054304:Anti-Mullerian Hormone / Q000235:genetics* / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D001559:Benzhydryl Compounds / Q000633:toxicity*; D004527:Egg Proteins / Q000235:genetics / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010636:Phenols / Q000633:toxicity*; D011374:Progesterone / Q000097:blood; D017208:Rats, Wistar; D046468:Sexual Development / Q000187:drug effects; D000098826:Bisphenol A Compounds
D054304:Anti-Mullerian Hormone; D051792:Basic Helix-Loop-Helix Proteins; D001559:Benzhydryl Compounds; D004527:Egg Proteins; D004958:Estradiol; D004968:Estrogens, Non-Steroidal; D006657:Histones; D010636:Phenols; D011374:Progesterone; C109920:Figla protein, mouse; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Bisphenol A; Environmental estrogen; Gene regulation; Ovary development; Prepubertal