Interleukin-2 and STAT5 in regulatory T cell development and function.
Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent studies describing how this critical signaling pathway entrains regulatory T cell differentiation and affects regulatory T cell function.
Center for Immunology; Masonic Cancer Center; and Department of Laboratory Medicine and Pathology; University of Minnesota; Minneapolis, MN USA.
Shawn A
SA
Mahmud
Luke S
LS
Manlove
Michael A
MA
Farrar
STAT5; autoimmunity; cytokines; interleukin-2; regulatory T cell development