Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes.
Generation of effective immune responses against pathogenic microbes depends on a fine balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) is essential in regulating this balance and has garnered renewed interest recently as a modulator of the response to infection at the JAK-STAT signaling axis of host responses. Here, we examine how IL-10 functions as the "master regulator" of immune responses through JAK-STAT, and provide a perspective from recent insights on bacterial, protozoan, and viral infection model systems. Pattern recognition and subsequent molecular events that drive activation of IL-10-associated JAK-STAT circuitry are reviewed and the implications for microbial pathogenesis are discussed.
School of Medical Sciences; Centre for Medicine and Oral Health; Griffith University; Gold Coast, QLD Australia.
Alison J
AJ
Carey
Chee K
CK
Tan
Glen C
GC
Ulett
host response; infection and immunity; interleukin-10; microbes; microbial pathogenesis; molecular and cellular biology