Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia.
A new class of highly oxygenated Schisandra nortriterpenoids, lancolides A-D (1-4), from Schisandra lancifolia, represents the first example of natural products that possess a tricyclo[6.3.0.0(2,11)]undecane-bridged system. Their structures were elucidated by NMR spectra, X-ray diffraction, and quantum chemical calculations. Lancolides A (1) and D (4) had specific antiplatelet aggregation induced by platelet-activating factor (PAF).
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, Shanghai Institute of Materia Medica , Chinese Academy of Sciences, Shanghai 201203, P. R. China, and University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
Yi-Ming
YM
Shi
Xin-Bo
XB
Wang
Xiao-Nian
XN
Li
Xiao
X
Luo
Zi-Ying
ZY
Shen
Yi-Ping
YP
Wang
Wei-Lie
WL
Xiao
Han-Dong
HD
Sun
D000473:Alkanes / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010972:Platelet Activating Factor / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011789:Quantum Theory; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
D000473:Alkanes; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D014315:Triterpenes; C587468:lancolide A; C587469:lancolide D; C022884:undecane