Effects of six-week cardiac rehabilitation and exercise on adiponectin in patients with acute coronary syndrome.
BACKGROUND
Increased adiponectin is a result of an anti-arteriosclerotic effect and is related to the prevention of arteriosclerosis. However, it is uncertain whether cardiac rehabilitation and exercise (CRE) increase adiponectin in patients after acute coronary syndrome (ACS).


OBJECTIVE
To assess the effects of CRE intervention on adiponectin in patients after ACS.


METHODS
Forty four patients participated in a cardiac rehabilitation programme after receiving percutaneous coronary intervention. The participants were divided into either an intervention (CRE) or a control (CON) group. Assessments were made at baseline and six weeks after the intervention for adiponectin, interleukin-6 (IL-6), tumour necrosis factor-a (TNF-a); high sensitivity C-reactive protein (hs-CRP), waist-to-hip ratio (WHR), and exercise duration.


RESULTS
After six weeks of exercise training, adiponectin significantly increased in both CRE and CON (p < 0.001 and p = 0.009, respectively). Adiponectin showed a significantly greater increase in CRE than in CON (p = 0.032). Significant differences were not observed in IL-6, TNF-a, and hs-CRP between the groups. However, VO(2max) and exercise duration significantly increased in CRE (p < 0.001). Significant increases in VO(2max) and exercise duration were also observed in CRE but not in CON (p < 0.001). WHR significantly decreased in CRE, with no significant change in CON (p < 0.05). The difference in adiponectin between the groups showed a significantly inverse relationship with the difference in WHR (R² = -0.376, p = 0.034).


CONCLUSIONS
Adiponectin and cardiopulmonary fitness were significantly increased in CRE after six weeks of intervention. Although reductions in inflammatory markers were not observed, a significant inverse correlation was observed between the changes in adiponectin and WHR in CRE. Therefore, six weeks of short-term CRE intervention had a significant anti-inflammatory effect.
Sanggye-Paik Hospital, Inje University. kyj1383@yahoo.com.
Hye-Jeong
HJ
Kim
Jae-Keun
JK
Oh
Chul
C
Kim
Haemi
H
Jee
Kyung-A
KA
Shin
Young-Joo
YJ
Kim
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000534:rehabilitation*; D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein