[Monitoring renal microcirculation perfusion alteration with contrast-enhanced ultrasound during cardiopulmonary bypass].
OBJECTIVE
To investigate the monitoring of renal microcirculation perfusion alteration with contrast-enhanced ultrasound (CEU) during cardiopulmonary bypass (CPB).


METHODS
Renal microcirculation perfusion before and during CPB was assessed by CEU. Time-intensity curve (TIC) were derived from three region of interest (ROI) using QLAB post-analysis software. Parameters such as TIC curve wash in slope (A), area under curve (AUC), peak intensity (DPI) as well as time to peak intensity (TTP) were then calculated.


RESULTS
Contrast-enhanced ultrasound showed a significant reduction (or elongation) of perfusion parameter (A, AUC, DPI, TTP) in all three regions (superficial cortex, deep cortex and medulla) during cardiopulmonary bypass in comparison with normal cardiac cycle.


CONCLUSIONS
Cardiopulmonary bypass (CPB) has a dramatic impact on renal microcirculation in pediatric patients which manifest as global reduction in renal perfusion as well as significant region perfusion difference. Contrast-enhanced ultrasound (CEU) could detect the renal microcirculation alteration during CPB.
Departement of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiao-Fei
XF
Zhong
Da
D
Zhu
Qiang
Q
Lu
Bin
B
Liu
Yu-Lan
YL
Peng
D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007223:Infant; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D045423:Microbubbles; D008833:Microcirculation; D008991:Monitoring, Physiologic / Q000379:methods; D014463:Ultrasonography
D003287:Contrast Media