Necrosuppurative orchitis and scrotal necrotizing dermatitis following intratesticular administration of zinc gluconate neutralized with arginine (EsterilSol) in 2 mixed-breed dogs.
Intratesticular injection of EsterilSol (zinc gluconate neutralized with arginine) is a chemical sterilant for male dogs sometimes used in population control campaigns. Adverse reactions have been reported in 1% to 4% of treated dogs, but detailed histomorphologic descriptions are lacking. During a behavioral study conducted in the Chilean Patagonia in 2012, severe necrosuppurative orchitis and ulcerative dermatitis were observed in 2 of 36 (6%) dogs sterilized with EsterilSol according to the manufacturer's instructions. Reactions were noted on days 8 and 7 postinjection and required scrotal ablation on days 8 and 13, respectively; neither reaction was associated with the injection site. Although self-trauma following administration may have contributed, the cause of the adverse reactions is uncertain. EsterilSol is a relatively uncomplicated method to sterilize male dogs, but the occurrence of severe adverse reactions several days after administration emphasizes the need for the provision of long-term monitoring and veterinary care during sterilization campaigns using this product.
Canadian Cooperative Wildlife Health Centre, Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada mforzan@upei.ca.
M J
MJ
Forzán
Veterinarians without Borders/Veterinarios sin Fronteras-Canada, Latin America Regional Office, Valdivia, Chile.
E
E
Garde
Veterinarians without Borders/Veterinarios sin Fronteras-Canada, Latin America Regional Office, Valdivia, Chile.
G E
GE
Pérez
Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada.
R V
RV
Vanderstichel
D000818:Animals; D002369:Castration / Q000009:adverse effects / Q000662:veterinary; D003872:Dermatitis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology*; D004285:Dogs; D005942:Gluconates / Q000009:adverse effects* / Q000378:metabolism; D006652:Histological Techniques / Q000662:veterinary; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D009920:Orchitis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D012611:Scrotum / Q000473:pathology*; D013737:Testis / Q000378:metabolism
D005942:Gluconates; C482583:zinc gluconate arginine
EsterilSol; adverse reaction; chemical castration; dog; orchitis; testicular necrosis; zinc gluconate neutralized with arginine