Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma.
BACKGROUND
Instillation of Mitomycin C (MMC) should prevent implantation of cancer cells released during endoscopic treatment and prevent recurrences as seen in carcinoma of the bladder.


OBJECTIVE
TO DEVELOP AND EVALUATE A PROTOCOL FOR A SINGLE DOSE MMC INSTILLATION FOLLOWING HOLMIUM: YAG laser ablation of upper urinary tract transitional cell carcinoma (UUT-TCC).


METHODS
A single institute prospective study.


METHODS
MMC instillations protocol was designed and offered to patients between August 2005 and April 2011. Following tumor ablation, MMC was instilled into upper urinary tract (UUT) over 40 minutes. All the patients were regularly followed up.


RESULTS
Twenty UUT units (19 patients) were managed for UUT-TCCs using our MMC protocol. Two UUT units had G1pTa tumors, 14 had G2pTa, 2 had G3pTa, and 2 had G3pT1. At a mean follow-up of 24 months (range 1-72 months), 13/20 (65%) of the UUT units remained cancer-free, 3 (15%) UUT units developed stricture and were treated with endoscopic dilatation, only 1 (5%) of these developed long-term complications. None of the patients developed postoperative renal impairment or systemic side-effects.


CONCLUSIONS
Using a set standard protocol, MMC can safely be instilled into the UUT after TCC ablation with minimal complications or side effects, good preservation of renal function, and with a low recurrences rate comparable to the literature.
Wales Deanery, Department Urology, Cardiff, UK and Islamic University of Gaza, College of Medicine, Gaza, Palestine.
Omar M
OM
Aboumarzouk
Bhaskar
B
Somani
Sarfraz
S
Ahmad
Ghulam
G
Nabi
Nicholas
N
Townell
Slawomir G
SG
Kata
Mitomycin C; transitional cell carcinoma; upper urinary tract; ureteroscopy