Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.
The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment.
Department of Molecular Biology, Building 6L, Umeå University, Umeå S-90187, Sweden.
Bengt
B
Hallberg
Ruth H
RH
Palmer
D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002986:Clinical Trials as Topic; D000077547:Crizotinib; D029721:Drosophila Proteins / Q000502:physiology; D019008:Drug Resistance, Neoplasm; D004790:Enzyme Induction; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000201:enzymology / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D008958:Models, Molecular; D009154:Mutation; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011720:Pyrazoles / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014178:Translocation, Genetic; D029961:Zebrafish Proteins / Q000502:physiology
D000970:Antineoplastic Agents; D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D011720:Pyrazoles; D011725:Pyridines; D029961:Zebrafish Proteins; D000077547:Crizotinib; C000626173:ALK protein, human; C000626174:Alk protein, mouse; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C532034:Scd-2 protein, C elegans