Immunokinetics: a new approach to vaccines. A working hypothesis.
This paper outlines the working hypothesis that immune response is triggered, beside antigenicity referred to by the two major theories of Burnet (1959) and Jerne (1974) by the kinetics of the antigen that enters the body or, in the case of an endogenous origin, there is released from compartments where it is normally sequestered. This hypothesis, for simplicity called immunokinetics, postulates that the intensity of the immune response grows with the increase of the rapidity of the above contact or release and, conversely, declines with its decrease. Sublingual administration allows, by speeding up the vaccines absorption, to optimize their efficacy, safety and uses. Kinetics is also discussed in connection with homeostatic and adaptive processes involved in evolution.
Fondazione di Noopolis, Rome, Italy. E-mail: bruno.silvestrini@noopolis.eu.
Bruno
B
Silvestrini
D000276:Adjuvants, Immunologic; D000286:Administration, Sublingual; D006801:Humans; D007700:Kinetics; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D014612:Vaccines