Experimental investigation of design parameters on dry powder inhaler performance.
The study aims to investigate the impact of various design parameters of a dry powder inhaler on the turbulence intensities generated and the performance of the dry powder inhaler. The flow fields and turbulence intensities in the dry powder inhaler are measured using particle image velocimetry (PIV) techniques. In vitro aerosolization and deposition a blend of budesonide and lactose are measured using an Andersen Cascade Impactor. Design parameters such as inhaler grid hole diameter, grid voidage and chamber length are considered. The experimental results reveal that the hole diameter on the grid has negligible impact on the turbulence intensity generated in the chamber. On the other hand, hole diameters smaller than a critical size can lead to performance degradation due to excessive particle-grid collisions. An increase in grid voidage can improve the inhaler performance but the effect diminishes at high grid voidage. An increase in the chamber length can enhance the turbulence intensity generated but also increases the powder adhesion on the inhaler wall.
School of Chemical and Biomedical Engineering (SCBE), Nanyang Technological University (NTU), Singapore, Singapore.
Nguyen Thi Quynh
NT
Ngoc
Lusi
L
Chang
Xinli
X
Jia
Raymond
R
Lau
D001993:Bronchodilator Agents / Q000737:chemistry; D019819:Budesonide / Q000737:chemistry; D058995:Dry Powder Inhalers / Q000295:instrumentation*; D004867:Equipment Design; D012212:Rheology
D001993:Bronchodilator Agents; D019819:Budesonide
Dry powder inhaler; Emitted dose; Fine particle fraction; Flow field; In vitro deposition; Turbulence intensity