Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect.
Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer-gemcitabine and polymer-doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China. Electronic address: liudechun2008@126.com.
Dechun
D
Liu
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Yanbin
Y
Chen
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Xiaoshan
X
Feng
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Miao
M
Deng
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Gangqiang
G
Xie
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Jianguang
J
Wang
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Like
L
Zhang
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Qipeng
Q
Liu
Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.
Pengfei
P
Yuan
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D000093542:Gemcitabine
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D003841:Deoxycytidine; D004317:Doxorubicin; D000093542:Gemcitabine
Doxorubicin; Drug delivery; Gemcitabine; Micelles; Polymer conjugates