title: Synthesis and biological evaluation of (E)-1-(substituted)-3-phenylprop-2-en-1-ones bearing rhodanines as potent anti-microbial agents.
abstract: Herein, we report the design, syntheses and in vitro anti-microbial activity of two series of rhodanines with chalcone moiety. Anti-microbial tests showed that some of the synthesized compounds exhibited good inhibition (MIC = 1-8 µg/mL) against multi-drug-resistant Gram-positive organisms, including methicillin resistant and quinolone-resistant Staphylococcus aureus, in which the compound 4g was found to be the most potent with minimum inhibitory concentration (MIC) value of 1 µg/mL against two methicillin-resistant S. aureus.
authors.affiliation: Department of Pharmacy, Jing Gangshan University College of Medicine , Ji'an , People's Republic of China .
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Song
authors.forename: Xian-Qing
authors.initials: XQ
authors.lastname: Deng
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Li
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Lan
authors.initials: L
authors.lastname: Hong
authors.forename: Hu-Ri
authors.initials: HR
authors.lastname: Piao
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C000595854:4-methyl-2-(5-(4-(3-(naphthalen-2-yl)-3-oxoprop-1-en-1-yl)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)pentanoic acid; D000900:Anti-Bacterial Agents; D047188:Chalcones; D012236:Rhodanine
keywords: Anti-bacterial; methicillin-resistant Staphylococcus aureus; rhodanine