title: Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning.
abstract: The Yusho poisoning incident, caused by rice oil contaminated with polychlorinated biphenyls (PCBs), polychlorinated quarterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) generated by heat-denatured PCBs, occurred in 1968 in western Japan. Although severe symptoms are rarely observed today, the levels of PCBs and PCDFs in the sera of Yusho patients remain high. The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity. Recent studies show that dioxin mediates its immune toxic effects via AhR and that AhR activation induces dysregulation of interleukin (IL)-17- producing T (TH17) cells. This study therefore hypothesized that Yusho patients would show dysregulated TH17 cell-mediated immune responses. To validate the hypothesis, levels of IL-17 and IL-22, each secreted by TH17 cells, along with IL-1β and IL-23 were measured in serum samples from 40 Yusho patients and 40 age-matched controls. Levels of tumor necrosis factor (TNF)-α potentially secreted by TH17 cell-stimulated neutrophils and macrophages were also measured. The results indicated that serum IL-17 levels, as well as those of IL-1β, IL-23, and TNFα, were significantly higher in Yusho patients than in controls. In contrast, serum IL-22 levels were significantly lower in the Yusho patients. These results suggest that Yusho patients have dysregulated TH17 cell-mediated immune responses that may be linked to inflammation.
authors.affiliation: Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan and.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kuwatsuka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Yuta
authors.initials: Y
authors.lastname: Koike
authors.forename: Fumihide
authors.initials: F
authors.lastname: Ogawa
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
authors.forename: Atsushi
authors.initials: A
authors.lastname: Utani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001572:Benzofurans / Q000633:toxicity; D002478:Cells, Cultured; D002722:Chlorobenzenes / Q000633:toxicity; D016207:Cytokines / Q000097:blood; D000072338:Dibenzofurans, Polychlorinated; D005260:Female; D005506:Food Contamination; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology*; D007564:Japan; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D018336:Receptors, Aryl Hydrocarbon; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology; D015854:Up-Regulation
chemical_list: D001572:Benzofurans; D002722:Chlorobenzenes; D016207:Cytokines; D000072338:Dibenzofurans, Polychlorinated; D018336:Receptors, Aryl Hydrocarbon; C022053:polychlorinated quaterphenyls; D011078:Polychlorinated Biphenyls
keywords: Dioxin; IL-17; IL-1β; IL-22; IL-23; TH17; TNFα; yusho