title: Methylphenidate does not influence smoking-reinforced responding or attentional performance in adult smokers with and without attention deficit hyperactivity disorder (ADHD).
abstract: Individuals with Attention Deficit Hyperactivity Disorder (ADHD) smoke cigarettes at rates higher than the general population and questions have been raised about how stimulant drugs-the frontline pharmacological treatment for ADHD-influence smoking risk and behavior in those with ADHD. In the present study adult regular smokers with (n = 16) and without (n = 17) ADHD participated in 3 experimental sessions in which they completed a Progressive Ratio (PR) task to measure the relative reinforcing effects of cigarette smoking and money after oral administration of placebo and 2 active doses of methylphenidate (10 mg and 40 mg). We also measured attention and inhibitory control via a Continuous Performance Test (CPT). Methylphenidate had no effect on smoking-reinforced responding, attention, or inhibitory control in either group. Attention and inhibitory control were associated with smoking-reinforced responding, but unsystematically and only in the non-ADHD group. Several design features, such as the value of the monetary response option, the PR schedule, and the potential effects of smoking on attention and inhibitory control, could have contributed to the negative findings and are discussed as such. Although inconsistent with some previous human laboratory studies of stimulant drugs and smoking, results are consistent with recent trials of stimulant drugs as adjuncts for smoking cessation in adult smokers with ADHD. In general, methylphenidate at mild and moderate doses did not influence the relative reinforcing effects of cigarette smoking in adults with and without ADHD.
authors.affiliation: Duke ADHD Program, Department of Psychiatry, Duke University School of Medicine.
authors.forename: Scott H
authors.initials: SH
authors.lastname: Kollins
authors.forename: Erin
authors.initials: E
authors.lastname: Schoenfelder
authors.forename: Joseph S
authors.initials: JS
authors.lastname: English
authors.forename: F Joseph
authors.initials: FJ
authors.lastname: McClernon
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Dew
authors.forename: Scott D
authors.initials: SD
authors.lastname: Lane
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012907:Smoking / Q000523:psychology*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate