title: Exocytosis and endocytosis in neuroendocrine cells: inseparable membranes!
abstract: Although much has been learned concerning the mechanisms of secretory vesicle formation and fusion at donor and acceptor membrane compartments, relatively little attention has been paid toward understanding how cells maintain a homeostatic membrane balance through vesicular trafficking. In neurons and neuroendocrine cells, release of neurotransmitters, neuropeptides, and hormones occurs through calcium-regulated exocytosis at the plasma membrane. To allow recycling of secretory vesicle components and to preserve organelles integrity, cells must initiate and regulate compensatory membrane uptake. This review relates the fate of secretory granule membranes after full fusion exocytosis in neuroendocrine cells. In particular, we focus on the potential role of lipids in preserving and sorting secretory granule membranes after exocytosis and we discuss the potential mechanisms of membrane retrieval.
authors.affiliation: Institut des Neurosciences Cellulaires et Intégratives (INCI), Centre National de la Recherche Scientifique (CNRS UPR 3212), Université de Strasbourg , Strasbourg , France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Houy
authors.forename: Pauline
authors.initials: P
authors.lastname: Croisé
authors.forename: Olga
authors.initials: O
authors.lastname: Gubar
authors.forename: Sylvette
authors.initials: S
authors.lastname: Chasserot-Golaz
authors.forename: Petra
authors.initials: P
authors.lastname: Tryoen-Tóth
authors.forename: Yannick
authors.initials: Y
authors.lastname: Bailly
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ory
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Bader
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gasman
keywords: chromaffin cells; compensatory endocytosis; exocytosis; membrane lipids; neuroendocrine cells