title: RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts.
abstract: The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
authors.affiliation: 1] Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA. [2] Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, 4058 Basel, Switzerland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Geisler
authors.forename: Jeff
authors.initials: J
authors.lastname: Coller
mesh_terms: D000818:Animals; D014644:Genetic Variation / Q000235:genetics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*
chemical_list: D062085:RNA, Long Noncoding