title: Rhodium(III)-amine dual catalysis for the oxidative coupling of aldehydes by directed C-H activation: synthesis of phthalides.
abstract: A novel oxidative coupling of aldehydes to form C3-substituted phthalides facilitated by co-operative dual catalysis of a Rh(III) complex and an aryl amine is reported. The reaction involves a cascade ortho C-H activation-insertion-annulation sequence. This methodology is efficient and applicable for the homo- and heterocoupling of various functionalized aldehydes generating the corresponding phthalides in moderate to high yields.
authors.affiliation: Organic Chemistry, Institute of Chemical and Engineering Sciences , 8 Biomedical Grove, Neuros, #07-01, Singapore 138665.
authors.forename: Peng Wen
authors.initials: PW
authors.lastname: Tan
authors.forename: Nur Asyikin Binte
authors.initials: NA
authors.lastname: Juwaini
authors.forename: Jayasree
authors.initials: J
authors.lastname: Seayad
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D001572:Benzofurans; D009942:Organometallic Compounds; C082022:phthalide; D012238:Rhodium