title: The relationship between Lin28 and the chemotherapy response of gastric cancer.
abstract: OBJECTIVE
  The aim of the study reported here was to identify whether a stem cell biomarker, Lin28, may predict the pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced gastric cancer.
  
  
  METHODS
  The study enrolled 47 patients with gastric cancer who underwent neoadjuvant chemotherapy followed by surgery between July 2004 and March 2012. Cancer tissue was biopsied by gastroscopy and Lin28 expression in the tissue was measured by immunohistochemistry. Statistical analyses were performed to identify the relationship between Lin28 expression and tumor regression grade.
  
  
  RESULTS
  Of the 47 cases, pathologic nonresponse was observed in 29 (61.7%) and pathologic response in 18 (38.3%). Receiver-operating characteristic curve analysis showed that the histoscore of Lin28 expression with 0.325 as a cutoff value could differentiate between pathologic response and nonresponse. Multivariable analysis showed that Lin28 expression was an independent predictive factor for pathologic response to neoadjuvant chemotherapy (P = 0.006).
  
  
  CONCLUSIONS
  Lin28 expression was associated with pathologic tumor response in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy. This may suggest that Lin28 can serve as a predictive biomarker for neoadjuvant chemotherapy in patients with gastric cancer.
authors.affiliation: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.forename: Rong Yue
authors.initials: RY
authors.lastname: Teng
authors.forename: Ji Chun
authors.initials: JC
authors.lastname: Zhou
authors.forename: Zi Nong
authors.initials: ZN
authors.lastname: Jiang
authors.forename: Chao Yang
authors.initials: CY
authors.lastname: Xu
authors.forename: Zi Duo
authors.initials: ZD
authors.lastname: Li
authors.forename: Qing Chuan
authors.initials: QC
authors.lastname: Wang
authors.forename: Chen Pu
authors.initials: CP
authors.lastname: Xu
authors.forename: Ju Feng
authors.initials: JF
authors.lastname: Guo
authors.forename: Jian Guo
authors.initials: JG
authors.lastname: Shen
authors.forename: Lin Bo
authors.initials: LB
authors.lastname: Wang
keywords: immunohistochemistry; neoadjuvant chemotherapy; pathologic tumor response; stem cell biomarker