title: Effectiveness of green tea in a randomized human cohort: relevance to diabetes and its complications.
abstract: Epidemiological studies have argued that green tea could mitigate diabetes and its complications. This study investigated the phytophenolic profile of Mauritian green tea and its antioxidant propensity. The effect of green tea on the risk factors: waist-hip ratio, glucose level, arterial pressure, antioxidant status, and alanine aminotransferase (ALT) in prediabetics was assessed. The experimental group consumed 3 cups of green tea daily for 14 weeks followed by a 2-week washout period. The control group followed a water regimen. Green tea contained high level of phenolics related to its antioxidant power. Green tea suppressed waist-hip ratio of women from a significant increase and suppressed mean arterial pressure of men and women from a significant decrease after week 14. It reduced ALT level in women by 13.0% (P < 0.1) while increasing the antioxidant potential of men and women sera by 2.7% (P < 0.1) and 5.1% (P < 0.1). The study timescale may have been too short to enable demonstration of effects on fasting plasma glucose and HbA1c outcomes. Green tea regimen could form part of a healthy lifestyle that might ameliorate features of metabolic syndrome and subsequent risks for diabetes and its complications. This trial is registered with ClinicalTrials.gov NCT01248143.
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, Réduit, Mauritius.
authors.forename: Naushad Ali
authors.initials: NA
authors.lastname: Toolsee
authors.forename: Okezie I
authors.initials: OI
authors.lastname: Aruoma
authors.forename: Teeluck K
authors.initials: TK
authors.lastname: Gunness
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kowlessur
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Dambala
authors.forename: Fatima
authors.initials: F
authors.lastname: Murad
authors.forename: Kreshna
authors.initials: K
authors.lastname: Googoolye
authors.forename: Diana
authors.initials: D
authors.lastname: Daus
authors.forename: Joseph
authors.initials: J
authors.lastname: Indelicato
authors.forename: Philippe
authors.initials: P
authors.lastname: Rondeau
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bourdon
authors.forename: Theeshan
authors.initials: T
authors.lastname: Bahorun
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D001786:Blood Glucose / Q000187:drug effects; D048909:Diabetes Complications / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology / Q000517:prevention & control; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry; D013662:Tea / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D010636:Phenols; D013662:Tea