title: Myc function in Drosophila.
abstract: Drosophila contains a single MYC gene. Like its vertebrate homologs, it encodes a transcription factor that activates many targets, including prominently genes involved in ribosome biogenesis and translation. This activity makes Myc a central regulator of growth and/or proliferation of many cell types, such as imaginal disc cells, polyploid cells, stem cells, and blood cells. Importantly, not only does Myc act cell autonomously but it also affects the fate of adjacent cells and tissues. This potential of Myc is harnessed by many different signaling pathways, involving, among others, Wg, Dpp, Hpo, ecdysone, insulin, and mTOR.
authors.affiliation: Julius-Maximilians-Universität Würzburg, Lehrstuhl für Biochemie und Molekularbiologie, Am Hubland, 97074 Würzburg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Gallant
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000502:physiology; D049628:Body Size / Q000235:genetics; D049109:Cell Proliferation; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D016259:Genes, myc / Q000502:physiology*; D060227:Imaginal Discs / Q000502:physiology; D007814:Larva / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D029721:Drosophila Proteins