title: Forces in epithelial origami.
abstract: Recent efforts examining forces during morphogenesis suggest a role for mechanical crosstalk between epithelium and mesenchyme in tissue patterning. Reporting in Science, Shyer et al. (2013) show that differences between the mechanical properties of the developing intestinal epithelium and surrounding smooth muscle fold the epithelium into villi via mucosal buckling.
authors.affiliation: Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: celesten@princeton.edu.
authors.forename: Celeste M
authors.initials: CM
authors.lastname: Nelson
mesh_terms: D000818:Animals; D041981:Gastrointestinal Tract / Q000196:embryology* / Q000648:ultrastructure*; D006801:Humans; D009024:Morphogenesis; D009130:Muscle, Smooth / Q000196:embryology*