title: Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts.
abstract: The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.
authors.affiliation: Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Sydney, Australia. Daniel.Chan@sswahs.nsw.gov.au.
authors.forename: Nady
authors.initials: N
authors.lastname: Braidy
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Gai
authors.forename: Ying Hua
authors.initials: YH
authors.lastname: Xu
authors.forename: Perminder
authors.initials: P
authors.lastname: Sachdev
authors.forename: Gilles J
authors.initials: GJ
authors.lastname: Guillemin
authors.forename: Xing-Mai
authors.initials: XM
authors.lastname: Jiang
authors.forename: J William O
authors.initials: JW
authors.lastname: Ballard
authors.forename: Martin P
authors.initials: MP
authors.lastname: Horan
authors.forename: Zhi Ming
authors.initials: ZM
authors.lastname: Fang
authors.forename: Beng H
authors.initials: BH
authors.lastname: Chong
authors.forename: Daniel Kam Yin
authors.initials: DK
authors.lastname: Chan