title: Aminopropyl carbazole analogues as potent enhancers of neurogenesis.
abstract: Neural stem cells are multipotent and self-renewing cells that can differentiate into new neurons and hold great promise for treating various neurological disorders including multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Small molecules that can trigger neurogenesis and neuroprotection are particularly useful not only because of their therapeutic implications but also because they can provide an invaluable tool to study the mechanisms of neurogenesis. In this report, we have developed and screened 25 aminopropyl carbazole derivatives that can enhance neurogenesis of cultured neural stem cells. Among these analogues, compound 9 demonstrated an excellent proneurogenic and neuroprotective activity with no apparent toxicity. We believe that compound 9 can serve as an excellent lead to develop various analogues and to study the underlying mechanisms of neurogenesis.
authors.affiliation: Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kong
authors.forename: Min-Hye
authors.initials: MH
authors.lastname: Park
authors.forename: Yongsung
authors.initials: Y
authors.lastname: Cho
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Jae-Yeon
authors.initials: JY
authors.lastname: Shin
authors.forename: Sunghye
authors.initials: S
authors.lastname: Jung
authors.forename: Jiyoun
authors.initials: J
authors.lastname: Lee
authors.lastname: Farhanullah
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jeewoo
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D058953:Neural Stem Cells / Q000166:cytology*; D055495:Neurogenesis / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D002227:Carbazoles; D018696:Neuroprotective Agents; D013449:Sulfonamides; C588296:N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide; D000096926:Benzenesulfonamides; C041514:carbazole
keywords: Aminopropyl carbazole; Neural stem cells; Neurodegenerative diseases; Neurogenesis; Neuroprotective agents