title: Reduced serum levels of triglyceride, very low density lipoprotein cholesterol and apolipoprotein B in Parkinson's disease patients.
abstract: BACKGROUND
  Previous studies have shown a lower incidence of stroke in Parkinson's disease (PD) patients. The role of the lipids and lipoproteins as risk factors for stroke is uncertain in the lower prevalence of stroke in PD patients.
  
  
  OBJECTIVE
  To explore the lipids and lipoproteins serum levels in PD patients.
  
  
  METHODS
  A retrospective study was performed on 110 PD patients (PD group), 130 controls with non-cerebrovascular neurological diseases (OD group), 140 acute intracerebral hemorrhage patients (ICH group) and 140 acute cerebral infarction patients (CI group). The records about serum levels of lipids and lipoproteins were analyzed.
  
  
  RESULTS
  There were significant differences for the serum level of triglyceride (F = 5.031, p=0.002), very low density lipoprotein cholesterol (F = 5.313, p=0.001), apolipoprotein B (F = 16.038, p<0.0001) in the four groups. PD group had a significantly lower serum level of triglyceride (TG) than the OD (p=0.032), ICH (p=0.00047) and CI (p=0.001) groups. Very low density lipoprotein cholesterol (VLDL-C) serum level was significantly lower in PD group than in OD (p=0.039), ICH (p=0.00021) and CI (p=0.001) groups. There was a significantly lower serum level of apolipoprotein B (apo B) in PD group than in OD (p=0.002), ICH (p<0.0001) and CI (p<0.0001) groups.
  
  
  CONCLUSIONS
  There are reduced serum levels of TG, VLDL-C and apo B in PD patients, which may be related to the decreased prevalence of stroke in PD patients.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.forename: Yanghua
authors.initials: Y
authors.lastname: Tian
authors.forename: Fangcheng
authors.initials: F
authors.lastname: Xu
authors.forename: Xianwen
authors.initials: X
authors.lastname: Chen
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000368:Aged; D001055:Apolipoproteins B / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood*
chemical_list: D001055:Apolipoproteins B; D015243:Cholesterol, VLDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides