title: GI tract tumors with melanocytic differentiation.
abstract: Gastrointestinal (GI) tract tumors with melanocytic differentiation may present significant diagnostic challenges both for the pathologist and the clinician. This comprehensive review discusses the relatively common as well as rare entities that have melanocytic differentiation in the GI tract. Clinical, histologic, immunohistochemical and molecular features are discussed along with prognosis and differential diagnosis.
authors.affiliation: *Department of Pathology, Division of Anatomic Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA †Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH.
authors.forename: Dipti M
authors.initials: DM
authors.lastname: Karamchandani
authors.forename: Deepa T
authors.initials: DT
authors.lastname: Patil
authors.forename: John R
authors.initials: JR
authors.lastname: Goldblum
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000556:secondary; D017600:Neuroectodermal Tumor, Melanotic / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000032:analysis; D054973:Perivascular Epithelioid Cell Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D018227:Sarcoma, Clear Cell / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D015514:Oncogene Proteins, Fusion; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins