title: Design and validation of a neuroprosthesis for the treatment of upper limb tremor.
abstract: Pathological tremor is the most prevalent movement disorder. In spite of the existence of various treatments for it, tremor poses a functional problem to a large proportion of patients. This paper presents the design and implementation of a novel neuroprosthesis for tremor management. The paper starts by reviewing a series of design criteria that were established after analyzing users needs and the expected functionality of the system. Then, it summarizes the design of the neuroprosthesis, which was built to meet the criteria defined previously. Experimental results with a representative group of 12 patients show that the neuroprosthesis provided significant (p < 0.001) and systematic tremor attenuation (in average 52.33 ± 25.48 %), and encourage its functional evaluation as a potential new treatment for tremor in a large cohort of patients.
authors.forename: J A
authors.initials: JA
authors.lastname: Gallego
authors.forename: E
authors.initials: E
authors.lastname: Rocon
authors.forename: J M
authors.initials: JM
authors.lastname: Belda-Lois
authors.forename: A D
authors.initials: AD
authors.lastname: Koutsou
authors.forename: S
authors.initials: S
authors.lastname: Mena
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: J L
authors.initials: JL
authors.lastname: Pons
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D009119:Muscle Contraction; D058117:Neural Prostheses; D011474:Prosthesis Design; D015203:Reproducibility of Results; D012371:Robotics; D014202:Tremor / Q000503:physiopathology / Q000628:therapy*; D034941:Upper Extremity / Q000503:physiopathology*; D055815:Young Adult