title: FKBP5 and CRHR1 polymorphisms moderate the stress-physical health association in a national sample.
abstract: OBJECTIVE
  Stressful life events experienced during childhood and as an adult negatively impact mental and physical health over the life span. This study examined polymorphisms from 2 hypothalamic-pituitary-adrenal axis-related genes previously associated with posttraumatic stress disorder-FKBP5 and CRHR1-as moderators of the impact of child abuse and adult stress on physical health.
  
  
  METHODS
  A national, community-based subsample of non-Hispanic European American respondents (n = 527) from a prospective longitudinal 3-year study of stress and coping (N = 2,729) provided saliva for genotyping.
  
  
  RESULTS
  FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and adult stress to predict increases in physical health ailments over 3 years. Child abuse and adult stress were strongly related to physician-diagnosed physical ailments among individuals with the risk alleles of both single nucleotide polymorphisms. Individuals carrying the low-risk homozygotic genotypes were protected from the long-term negative health implications of experiencing both child abuse and adult stress.
  
  
  CONCLUSIONS
  Consistent with theories linking the hypothalamic-pituitary-adrenal axis with stress-related disease, hypothalamic-pituitary-adrenal axis polymorphism genotypes moderated the association between exposure to child abuse/adult stress and long-term physical health outcomes in a national sample.
authors.affiliation: Program in Nursing Science, University of California, Irvine.
authors.forename: Jared
authors.initials: J
authors.lastname: Lessard
authors.affiliation: Program in Nursing Science, University of California, Irvine.
authors.forename: E Alison
authors.initials: EA
authors.lastname: Holman
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D054523:Adult Survivors of Child Abuse / Q000523:psychology*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006304:Health Status; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D012463:Saliva; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics* / Q000503:physiopathology; D013315:Stress, Psychological / Q000235:genetics* / Q000503:physiopathology; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics; D055815:Young Adult; D000099052:CRF Receptor, Type 1; D000099159:Tacrolimus Binding Protein 5
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D022021:Tacrolimus Binding Proteins; D000099052:CRF Receptor, Type 1; D000099159:Tacrolimus Binding Protein 5