title: Functional polymorphisms in surfactant protein genes and chronic obstructive pulmonary disease risk: a meta-analysis.
abstract: OBJECTIVE
  Increasing scientific evidence suggests that functional polymorphisms in surfactant protein (SP) genes may contribute to increasing susceptibility to chronic obstructive pulmonary disease (COPD), but many existing studies have yielded inconclusive results. This meta-analysis aims to assess the exact role of SP gene polymorphisms in the development of COPD.
  
  
  METHODS
  An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through May 1st, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratio (OR) with 95% confidence interval (CI) were calculated.
  
  
  RESULTS
  Seven case-control studies were included with a total of 2761 subjects, including 1274 COPD cases and 1482 healthy controls. Our meta-analysis revealed that common polymorphisms in the SP-A gene may be associated with an increased risk of COPD (allele model: OR=1.53, 95% CI: 1.14-2.05, p=0.005; dominant model: OR=1.65, 95% CI: 1.02-2.69, p=0.043; recessive model: OR=1.66, 95% CI: 1.17-2.35, p=0.005; homozygous model: OR=2.06, 95% CI: 1.24-3.41, p=0.005; heterozygous model: OR=1.59, 95% CI: 1.13-2.22, p=0.007), especially among Asian populations. However, there was no evidence for any association between common polymorphisms in the SP-B and SP-D genes and COPD risk (all p>0.05).
  
  
  CONCLUSIONS
  The current meta-analysis indicates that common polymorphisms in the SP-A gene may contribute to increasing susceptibility to COPD, especially among Asian populations.
authors.affiliation: Department of Emergency, The First Affiliated Hospital of China Medical University , Shenyang, People's Republic of China .
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Liu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D039781:PubMed; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology / Q000235:genetics*; D037661:Pulmonary Surfactant-Associated Proteins / Q000235:genetics*
chemical_list: D037661:Pulmonary Surfactant-Associated Proteins