title: Translocation-associated salivary gland tumors: a review and update.
abstract: In recent years the discovery of translocations and the fusion oncogenes that they result in has changed the way diagnoses are made in the salivary gland. These genetic aberrations are recurrent and reproducible and at the very least serve as powerful diagnostic tools in salivary gland diagnosis and salivary gland classification. They also show promise as prognostic markers and hopefully as targets of therapy. Many of these fusions have been found in other tumor types that show little to no overlap with their salivary gland counterparts, but effectively they are specific within the salivary gland. In this review the 5 tumors currently known to harbor translocations will be discussed, namely pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma, mammary analog secretory carcinoma, and hyalinizing clear cell carcinoma. The discovery and implications of each fusion will be highlighted and how they have helped reshape the current classification of salivary gland tumors.
authors.affiliation: *Department of Pathology, University Health Network †Department of Pathobiology and Laboratory medicine, University of Toronto, ON, Canada.
authors.forename: Ilan
authors.initials: I
authors.lastname: Weinreb
mesh_terms: D051697:Activating Transcription Factor 1 / Q000235:genetics; D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000235:genetics* / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D051839:NFI Transcription Factors / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020626:Oncogene Proteins v-myb / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D020812:Receptor, trkC / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D051697:Activating Transcription Factor 1; D002148:Calmodulin-Binding Proteins; D004268:DNA-Binding Proteins; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D020626:Oncogene Proteins v-myb; D015514:Oncogene Proteins, Fusion; D050783:Proto-Oncogene Proteins c-ets; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins; D020812:Receptor, trkC; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000097764:ETS Translocation Variant 6 Protein; C531110:ATF1 protein, human; C495791:CRTC3 protein, human; C500986:EWSR1 protein, human; C471297:MAML2 protein, human; C110754:NFIB protein, human; C104382:PLAG1 protein, human