title: Significant association of APOA5 and APOC3 gene polymorphisms with meat quality traits in Kele pigs.
abstract: Apolipoprotein A5 (APOA5) and C3 (APOC3) genes are involved in the PPAR lipid metabolism pathway and thus associated with elevated triglyceride levels. However, whether APOA5 and APOC3 genetic polymorphisms affect intramuscular fat deposition and other meat quality traits remains unknown in pigs. One hundred and seventy-one Kele pigs were sampled to investigate genetic variants in the APOA5 and APOC3 genes and their association with seven pork quality traits. We identified 5 single nucleotide polymorphisms (SNPs) in the promoter region of the APOA5 gene and 17 SNPs in the APOC3 gene. Linkage disequilibrium analysis revealed 5 complete linkage disequilibria among these 22 SNPs. We found that 10 SNPs were significantly correlated with meat quality traits, including the mutation A5/-769 in the APOA5 gene, which was significantly associated with cooked weight percentage, and 9 SNPs in the APOC3 gene that were significantly associated with drip loss rate, meat color value of longissimus dorsi muscle and shear force. Therefore, these SNP markers will be useful for marker-assisted selection for improved pork quality.
authors.affiliation: Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Guizhou University, Ministry of Education, Guiyang, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Hui
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Yang
authors.forename: R Y
authors.initials: RY
authors.lastname: Liu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: C J
authors.initials: CJ
authors.lastname: Xiang
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Y H
authors.initials: YH
authors.lastname: Ding
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhang
authors.forename: B R
authors.initials: BR
authors.lastname: Wang
mesh_terms: D000818:Animals; D001054:Apolipoproteins A / Q000235:genetics*; D001056:Apolipoproteins C / Q000235:genetics*; D063427:Food Quality; D005787:Gene Frequency; D015810:Linkage Disequilibrium; D008460:Meat / Q000032:analysis*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000235:genetics*; D014280:Triglycerides
chemical_list: D001054:Apolipoproteins A; D001056:Apolipoproteins C; D014280:Triglycerides