title: The role of proprioceptive feedback in Parkinsonian resting tremor.
abstract: In this paper we use a closed-loop force feedback system to investigate the effect of altering proprioceptive feedback on EEG and resting tremor in Parkinson's Disease. A velocity dependent counterforce simulating viscous friction was provided by haptic robots with simultaneous recording of kinematics, EMG and EEG while a patient was on and off dopaminergic medication' We were able to reduce the amplitude of the tremor. We also showed that force feedback shifts the center of EEG-EMG coherence posteriorly toward the somatosensory regions, which may have ramifications for noninvasive therapies.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Govil
authors.forename: Abraham
authors.initials: A
authors.lastname: Akinin
authors.forename: Samuel
authors.initials: S
authors.lastname: Ward
authors.forename: Joseph
authors.initials: J
authors.lastname: Snider
authors.forename: Markus
authors.initials: M
authors.lastname: Plank
authors.forename: Gert
authors.initials: G
authors.lastname: Cauwenberghs
authors.forename: Howard
authors.initials: H
authors.lastname: Poizner
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001921:Brain / Q000502:physiology; D004298:Dopamine / Q000737:chemistry; D015259:Dopamine Agents / Q000627:therapeutic use; D004569:Electroencephalography; D004576:Electromyography / Q000379:methods*; D056228:Feedback, Sensory; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D009068:Movement; D010300:Parkinson Disease / Q000503:physiopathology*; D010363:Pattern Recognition, Automated; D012146:Rest; D012371:Robotics; D012815:Signal Processing, Computer-Assisted; D014202:Tremor / Q000503:physiopathology*
chemical_list: D015259:Dopamine Agents; D004298:Dopamine