title: Polymorphisms in the organic anion transporting polypeptide genes influence liver parenchymal enhancement in gadoxetic acid-enhanced MRI.
abstract: OBJECTIVE
  This study aimed to investigate whether genetic polymorphisms of the organic anion transporting polypeptides influence hepatic enhancement in gadoxetic acid-enhanced MRI.
  
  
  METHODS
  We analyzed the genotypes of SLCO1B1 388A>G, SLCO1B1 521T>C, SLCO1B3 334T>G and NR1H4 -1G>T and calculated the mean quantitative liver-spleen contrast ratio, as an index of liver parenchymal enhancement, in 226 patients with liver disease.
  
  
  RESULTS
  Multiple linear regression analysis using the mean quantitative liver-spleen contrast ratio as the dependent variable revealed that not only Child-Pugh score, but also SLCO1B1*1b haplotype (β = 0.12; p = 0.04), were significant predictors of liver parenchymal enhancement. In addition, SLCO1B3 334T>G (β = -0.18; p = 0.03) was a significant predictor when the data were analyzed in a subgroup of 117 patients, excluding the carriers of NR1H4 -1G>T, who reportedly exhibit reduced transcriptional activity of SLCO1B3.
  
  
  CONCLUSIONS
  These genetic variants, as well as hepatic function, may contribute to individual differences in hepatic enhancement with gadoxetic acid.
authors.affiliation: Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan.
authors.forename: Hironao
authors.initials: H
authors.lastname: Okubo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Kokubu
authors.forename: Akihisa
authors.initials: A
authors.lastname: Miyazaki
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000368:Aged; D005260:Female; D019786:Gadolinium DTPA / Q000378:metabolism*; D006239:Haplotypes; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000235:genetics*; D027381:Liver-Specific Organic Anion Transporter 1; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D027361:Organic Anion Transporters / Q000235:genetics*; D029362:Organic Anion Transporters, Sodium-Independent / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D000074542:Solute Carrier Organic Anion Transporter Family Member 1B3
chemical_list: D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; D029362:Organic Anion Transporters, Sodium-Independent; C503999:SLCO1B1 protein, human; C421209:SLCO1B3 protein, human; D000074542:Solute Carrier Organic Anion Transporter Family Member 1B3; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA