title: Edaravone for acute stroke: Meta-analyses of data from randomized controlled trials.
abstract: OBJECTIVE
  To assess the effectiveness of edaravone for acute stroke including ischemic stroke and intracerebral hemorrhage (ICH).
  
  
  METHODS
  We identified randomized controlled trials with comprehensive searches and performed systematic reviews according to the Cochrane methods of systematical reviews.
  
  
  RESULTS
  Edaravone can reduce the rate of death or long-term disability significantly for acute ischemic stroke (AIS) (RR = 0.65; 95%CI, 0.48 to 0.89, p = 0.007). However, sensitivity analysis yielded a different result. Edaravone can also improve the short-term neurological impairment of AIS (MD = 7.09; 95%CI, 5.12 to 9.05, p < 0.00001), and ICH (MD = -4.32; 95%CI, -5.35 to -3.29, p < 0.00001).
  
  
  CONCLUSIONS
  Edaravone is beneficial in improving neurological impairment resulting from AIS and ICH. However, currently there is no enough convincing evidence that edaravone reduces death or long-term disability for AIS and ICH.
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .|b Department of Neurology , Nanjing First Hospital, Nanjing Medical University , Nanjing , PR China , and.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Cui
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .|c Department of Neurology , People's Hospital of Deyang City , Deyang , PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .
authors.forename: Canfei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , West China Hospital, Sichuan University , Chengdu , PR China .
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000983:Antipyrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy*
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine
keywords: Free radical scavenger; acute stroke treatment; meta-analysis