title: Clinical, dermoscopic and histopathological features of eccrine poroid neoplasms.
abstract: BACKGROUND
  Eccrine poroma (EP) belongs to the group of benign adnexal tumors, but cases of eccrine porocarcinoma (EPC) arising on long-standing and untreated EP suggest a certain risk of malignant transformation.
  
  
  OBJECTIVE
  To describe the clinical, dermoscopic and histopathologic features associated with different extremes in the spectrum of eccrine poroid neoplasms and to review the according literature.
  
  
  METHODS
  A retrospective analysis of patient characteristics and morphologic features associated with EP, EPC in situ and invasive porocarcinoma patients who attended two skin lesion clinics in Italy and Turkey between 2010 and 2011.
  
  
  RESULTS
  A total of 4 cases including 1 EP, 1 EPC in situ and 2 cases of invasive EPC in 4 patients were analyzed. Recent changes including bleeding, ulceration and sudden enlargement of a pre-existing lesion were associated with malignant transformation. Dermoscopically, polymorphous vessels consisting of coiled, hairpin and linear vessels were seen at all stages of progression. Histopathological findings of EPC in situ were limited to the epidermal component and were evident only at higher magnification.
  
  
  CONCLUSIONS
  Clinicians and pathologists should carefully evaluate EPs with a recent history of change and erosion in order to avoid overlooking the potential development of EPC.
authors.affiliation: 2nd Department of Dermatology, Athens University School of Medicine, Attikon General University Hospital, Athens, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Sgouros
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piana
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
authors.forename: Elvira
authors.initials: E
authors.lastname: Moscarella
authors.forename: Isil Kilinc
authors.initials: IK
authors.lastname: Karaarslan
authors.forename: Taner
authors.initials: T
authors.lastname: Akalin
authors.forename: Fezal
authors.initials: F
authors.lastname: Ozdemir
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D046169:Dermoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D057090:Eccrine Porocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology*