title: Electrophysiological effects of an anti-influenza drug oseltamivir on the guinea-pig atrium: comparison with those of pilsicainide.
abstract: We assessed the effects of oseltamivir on the conduction velocity and effective refractory period in the guinea-pig atrium in comparison with those of a class Ic antiarrhythmic drug pilsicainide. The recording and stimulating electrodes were attached on the epicardium close to the sinus nodal region and on the left atrial appendage. Oseltamivir (10-100 µM) as well as pilsicainide (1-10 µM) decreased the atrial conduction velocity in a frequency-dependent manner. Both drugs also increased the effective refractory period in both atria; but the frequency-dependent property of oseltamivir was lacking in the left atrium, and it was less obvious in the right atrium compared with that of pilsicainide. These results suggest that oseltamivir can directly modify the electrophysiological functions in the guinea-pig atrium possibly via combination of Na(+) and K(+) channel-blocking actions.
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University.
authors.forename: Akira
authors.initials: A
authors.lastname: Takahara
authors.forename: Sanae
authors.initials: S
authors.lastname: Suzuki
authors.forename: Mihoko
authors.initials: M
authors.lastname: Hagiwara
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nozaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation; D016275:Atrial Function / Q000187:drug effects*; D016279:Atrial Function, Left / Q000187:drug effects; D016280:Atrial Function, Right / Q000187:drug effects; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects*; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D026902:Potassium Channel Blockers / Q000494:pharmacology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D026941:Sodium Channel Blockers / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D000998:Antiviral Agents; D026902:Potassium Channel Blockers; D026941:Sodium Channel Blockers; D053139:Oseltamivir; D008012:Lidocaine; C042288:pilsicainide