title: Preeclampsia is an independent risk factor for spontaneous intestinal perforation in very preterm infants.
abstract: BACKGROUND
  Spontaneous intestinal perforation (SIP) is an important surgical emergency in preterm infants.
  
  
  OBJECTIVE
  To evaluate the effect of maternal preeclampsia on development of SIP in premature infants.
  
  
  METHODS
  Retrospective observational study in a large tertiary neonatal intensive care unit.
  
  
  METHODS
  The preterm infants of ≤32 weeks of gestational age and birthweight ≤1500 g who were hospitalized were enrolled.
  
  
  METHODS
  The primary outcome was to determine the association between preeclampsia and SIP.
  
  
  RESULTS
  A total of 22 infants had SIP diagnosis. The incidence of SIP in infants born to preeclamptic mothers (6.2%) was significantly higher compared with those born to normotensive mothers (0.2%). In multinominal logistic regression model, preeclampsia was found to be an independent risk factor of SIP with an odds ratio of 13.5 (95% confidence interval 2.82-65.1).
  
  
  CONCLUSIONS
  Maternal preeclampsia seemed to be an independent risk factor for development of SIP in premature infants.
authors.affiliation: Zekai Tahir Burak Maternity Teaching Hospital, Division of Pediatric Surgery , Ankara , Turkey .
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yılmaz
authors.forename: H Gözde Kanmaz
authors.initials: HG
authors.lastname: Kutman
authors.forename: Hülya Özkan
authors.initials: HÖ
authors.lastname: Ulu
authors.forename: F Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uraş
authors.forename: S Suna
authors.initials: SS
authors.lastname: Oğuz
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000209:etiology*; D019102:Infant, Very Low Birth Weight; D007416:Intestinal Perforation / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D012422:Rupture, Spontaneous / Q000453:epidemiology / Q000209:etiology
keywords: Antenatal steroids; intrauterin growth retardation; preeclampsia; prematurity; spontaneous intestinal perforation