title: DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells.
abstract: Decoy receptor 3 (DcR3) is considered to have anti‑apoptotic and pro-metastatic functions, suggesting it might be a therapeutic target. We examined the role and mechanisms of DcR3 on growth and the metastatic ability of SW480 colon cancer cells to provide therapeutic information for targeting DcR3 by RNA interference (RNAi) technology. Growth and the metastatic ability were inhibited, apoptosis was induced and cell cycle profile was changed after decreasing DcR3 expression, with lower levels of vascular endothelial growth factors (VEGFs) and matrix metalloproteinases (MMPs) expression. Our results implied the therapeutic potential of silencing DcR3 expression by RNAi in colon cancer.
authors.affiliation: Center for Clinical Pathology, Capital Medical University, Beijing 100069, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Ying-Chen
authors.initials: YC
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Tao
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Yan-Pei
authors.initials: YP
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Ji-Xiang
authors.initials: JX
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Dai
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020782:Matrix Metalloproteinases / Q000096:biosynthesis; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D034622:RNA Interference; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000096:biosynthesis / Q000235:genetics*; D042442:Vascular Endothelial Growth Factors / Q000096:biosynthesis
chemical_list: D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human; D042442:Vascular Endothelial Growth Factors; D020782:Matrix Metalloproteinases