title: Discovery and refinement of loci associated with lipid levels.
abstract: Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Cristen J
authors.initials: CJ
authors.lastname: Willer
authors.affiliation: Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Schmidt
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Sebanti
authors.initials: S
authors.lastname: Sengupta
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.|Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
authors.forename: Gina M
authors.initials: GM
authors.lastname: Peloso
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Gustafsson
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Kanoni
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala, Sweden.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ganna
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
authors.forename: Martin L
authors.initials: ML
authors.lastname: Buchkovich
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.|Harvard Medical School, Boston MA 02115, USA.
authors.forename: Samia
authors.initials: S
authors.lastname: Mora
authors.affiliation: Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland.|Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
authors.forename: Jacques S
authors.initials: JS
authors.lastname: Beckmann
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Bragg-Gresham
authors.affiliation: Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Hsing-Yi
authors.initials: HY
authors.lastname: Chang
authors.affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Demirkan
authors.affiliation: Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Heleen M
authors.initials: HM
authors.lastname: Den Hertog
authors.affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Do
authors.affiliation: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Donnelly
authors.affiliation: Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.|Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Georg B
authors.initials: GB
authors.lastname: Ehret
authors.affiliation: Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.|Estonian Genome Center of the University of Tartu, Tartu, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
authors.forename: Tõnu
authors.initials: T
authors.lastname: Esko
authors.affiliation: Department of Genetics, Washington University School of Medicine, USA.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Feitosa
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
authors.forename: Teresa
authors.initials: T
authors.lastname: Ferreira
authors.affiliation: Estonian Genome Center of the University of Tartu, Tartu, Estonia.
authors.forename: Krista
authors.initials: K
authors.lastname: Fischer
authors.affiliation: Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fontanillas
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Ross M
authors.initials: RM
authors.lastname: Fraser
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Freitag
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Deepti
authors.initials: D
authors.lastname: Gurdasani
authors.affiliation: Hjelt Institute, Department of Public Health, University of Helsinki, Finland.
authors.forename: Kauko
authors.initials: K
authors.lastname: Heikkilä
authors.affiliation: Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom.
authors.forename: Elina
authors.initials: E
authors.lastname: Hyppönen
authors.affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.|Centre for Medical Systems Biology, Leiden, the Netherlands.
authors.forename: Aaron
authors.initials: A
authors.lastname: Isaacs
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Anne U
authors.initials: AU
authors.lastname: Jackson
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.|Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
authors.forename: Åsa
authors.initials: Å
authors.lastname: Johansson
authors.affiliation: Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK.
authors.forename: Toby
authors.initials: T
authors.lastname: Johnson
authors.affiliation: Biocenter Oulu, University of Oulu, Oulu, Finland.|Institute of Health Sciences, University of Oulu, Finland.
authors.forename: Marika
authors.initials: M
authors.lastname: Kaakinen
authors.affiliation: Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Johannes
authors.initials: J
authors.lastname: Kettunen
authors.affiliation: Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany.|Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Kleber
authors.affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
authors.forename: Jian'an
authors.initials: J
authors.lastname: Luan
authors.affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
authors.forename: Leo-Pekka
authors.initials: LP
authors.lastname: Lyytikäinen
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Patrik K E
authors.initials: PKE
authors.lastname: Magnusson
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mangino
authors.affiliation: Estonian Genome Center of the University of Tartu, Tartu, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
authors.forename: Evelin
authors.initials: E
authors.lastname: Mihailov
authors.affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
authors.forename: May E
authors.initials: ME
authors.lastname: Montasser
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.|Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Müller-Nurasyid
authors.affiliation: Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Ilja M
authors.initials: IM
authors.lastname: Nolte
authors.affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: O'Connell
authors.affiliation: Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.|Division of Genetics, Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Cameron D
authors.initials: CD
authors.lastname: Palmer
authors.affiliation: Estonian Genome Center of the University of Tartu, Tartu, Estonia.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Markus
authors.initials: M
authors.lastname: Perola
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Ann-Kristin
authors.initials: AK
authors.lastname: Petersen
authors.affiliation: Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, 09042, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Sanna
authors.affiliation: Massachusetts General Hospital/Broad Institute, Harvard University, Cambridge, MA, USA.
authors.forename: Richa
authors.initials: R
authors.lastname: Saxena
authors.affiliation: Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Service
authors.affiliation: Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
authors.forename: Sonia
authors.initials: S
authors.lastname: Shah
authors.affiliation: Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden.|Department of Odontology, Umeå University, Umeå, Sweden.|Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Shungin
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.|Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, 09042, Italy.|Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 SS, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Sidore
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala, Sweden.|Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ci
authors.initials: C
authors.lastname: Song
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.|Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Rona J
authors.initials: RJ
authors.lastname: Strawbridge
authors.affiliation: Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Ida
authors.initials: I
authors.lastname: Surakka
authors.affiliation: Clinical Research Branch, National Institute Health, Baltimore, MD, USA.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Teslovich
authors.affiliation: deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
authors.forename: Gudmar
authors.initials: G
authors.lastname: Thorleifsson
authors.affiliation: Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Evita G
authors.initials: EG
authors.lastname: Van den Herik
authors.affiliation: Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA.|Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA.
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Voight
authors.affiliation: Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Volcik
authors.affiliation: HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
authors.forename: Lindsay L
authors.initials: LL
authors.lastname: Waite
authors.affiliation: MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wong
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.|Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhang
authors.affiliation: HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
authors.forename: Devin
authors.initials: D
authors.lastname: Absher
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
authors.forename: Gershim
authors.initials: G
authors.lastname: Asiki
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke's Hospital Cambridge CB2 OQQ, UK.
authors.forename: Inês
authors.initials: I
authors.lastname: Barroso
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Latonya F
authors.initials: LF
authors.lastname: Been
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Bolton
authors.affiliation: Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Bonnycastle
authors.affiliation: Department of Experimental Medicine, University of Milano Bicocca, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Brambilla
authors.affiliation: MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA.
authors.forename: Mary S
authors.initials: MS
authors.lastname: Burnett
authors.affiliation: Research Centre on Public Health, University of Milano Bicocca, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Cesana
authors.affiliation: Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dimitriou
authors.affiliation: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
authors.forename: Alex S F
authors.initials: ASF
authors.lastname: Doney
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Döring
authors.affiliation: Institute of Health Sciences, University of Oulu, Finland.|Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Elliott
authors.affiliation: MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Epstein
authors.affiliation: The Laboratory in Mjodd, 108 Reykjavik, Iceland.
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Ingi Eyjolfsson
authors.affiliation: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Bruna
authors.initials: B
authors.lastname: Gigante
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Mark O
authors.initials: MO
authors.lastname: Goodarzi
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Martha L
authors.initials: ML
authors.lastname: Gravito
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Groves
authors.affiliation: Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.affiliation: Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Hartikainen
authors.affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hayward
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
authors.forename: Dena
authors.initials: D
authors.lastname: Hernandez
authors.affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Hicks
authors.affiliation: deCODE Genetics/Amgen, 101 Reykjavik, Iceland.
authors.forename: Hilma
authors.initials: H
authors.lastname: Holm
authors.affiliation: Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Hung
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Jones
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
authors.forename: Pontiano
authors.initials: P
authors.lastname: Kaleebu
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: John J P
authors.initials: JJP
authors.lastname: Kastelein
authors.affiliation: Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Kim
authors.affiliation: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.|Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.
authors.forename: Norman
authors.initials: N
authors.lastname: Klopp
authors.affiliation: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
authors.forename: Pirjo
authors.initials: P
authors.lastname: Komulainen
authors.affiliation: Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
authors.forename: Meena
authors.initials: M
authors.lastname: Kumari
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
authors.forename: Claudia
authors.initials: C
authors.lastname: Langenberg
authors.affiliation: Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.|Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.|The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, USA.|The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at ount Sinai, New York, USA.|The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York.
authors.forename: Ruth J F
authors.initials: RJF
authors.lastname: Loos
authors.affiliation: Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
authors.forename: François
authors.initials: F
authors.lastname: Mach
authors.affiliation: School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: McArdle
authors.affiliation: Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Meisinger
authors.affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.
authors.forename: Braxton D
authors.initials: BD
authors.lastname: Mitchell
authors.affiliation: Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Müller
authors.affiliation: Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA.
authors.forename: Ramaiah
authors.initials: R
authors.lastname: Nagaraja
authors.affiliation: Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Narisu
authors.initials: N
authors.lastname: Narisu
authors.affiliation: Department of Clinical Pharmacology, University of Tampere School of Medicine, Tamperew 33014, Finland.|Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland.|Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Tuomo V M
authors.initials: TVM
authors.lastname: Nieminen
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Nsubuga
authors.affiliation: Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland.
authors.forename: Isleifur
authors.initials: I
authors.lastname: Olafsson
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.|MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom.
authors.forename: Ken K
authors.initials: KK
authors.lastname: Ong
authors.affiliation: Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.|Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United ingdom.
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.|Department of Statistical Sciences, University College of London, London, United Kingdom.
authors.forename: Theodore
authors.initials: T
authors.lastname: Papamarkou
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Cristina
authors.initials: C
authors.lastname: Pomilla
authors.affiliation: Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.|National Institute for Health and Welfare, Oulu, Finland.
authors.forename: Anneli
authors.initials: A
authors.lastname: Pouta
authors.affiliation: Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.|Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
authors.affiliation: Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.|Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA.
authors.forename: Muredach P
authors.initials: MP
authors.lastname: Reilly
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.|Harvard Medical School, Boston MA 02115, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.|Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.|Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, The Netherlands.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Igor
authors.initials: I
authors.lastname: Rudan
authors.affiliation: Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland.
authors.forename: Aimo
authors.initials: A
authors.lastname: Ruokonen
authors.affiliation: National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.|Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK.
authors.forename: Nilesh
authors.initials: N
authors.lastname: Samani
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
authors.forename: Hubert
authors.initials: H
authors.lastname: Scharnagl
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.|School of International Development, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
authors.forename: Janet
authors.initials: J
authors.lastname: Seeley
authors.affiliation: Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Kaisa
authors.initials: K
authors.lastname: Silander
authors.affiliation: University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
authors.forename: Alena
authors.initials: A
authors.lastname: Stančáková
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Stirrups
authors.affiliation: Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Swift
authors.affiliation: INSERM UMRS 937, Pierre and Marie Curie University, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.|Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.|Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, The Netherlands.
authors.forename: Andre G
authors.initials: AG
authors.lastname: Uitterlinden
authors.affiliation: Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.|LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: L Joost
authors.initials: LJ
authors.lastname: van Pelt
authors.affiliation: Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.|Division of Genetics, Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Sailaja
authors.initials: S
authors.lastname: Vedantam
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Wainwright
authors.affiliation: LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Cisca
authors.initials: C
authors.lastname: Wijmenga
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Wild
authors.affiliation: Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands.
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.affiliation: Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Wilsgaard
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: James F
authors.initials: JF
authors.lastname: Wilson
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Young
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
authors.forename: Jing Hua
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Adair
authors.affiliation: Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Themistocles L
authors.initials: TL
authors.lastname: Assimes
authors.affiliation: Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.affiliation: Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica.
authors.forename: Franklyn
authors.initials: F
authors.lastname: Bennett
authors.affiliation: Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland.
authors.forename: Murielle
authors.initials: M
authors.lastname: Bochud
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany.|Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Boehm
authors.affiliation: Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands.
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
authors.affiliation: Department of Genetics, Washington University School of Medicine, USA.
authors.forename: Ingrid B
authors.initials: IB
authors.lastname: Borecki
authors.affiliation: Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Bornstein
authors.affiliation: Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland.|Ministry of Health, Victoria, Republic of Seychelles.
authors.forename: Pascal
authors.initials: P
authors.lastname: Bovet
authors.affiliation: Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Michel
authors.initials: M
authors.lastname: Burnier
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.affiliation: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Aravinda
authors.initials: A
authors.lastname: Chakravarti
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.|Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom.|Imperial College Healthcare NHS Trust, London, United Kingdom.
authors.forename: John C
authors.initials: JC
authors.lastname: Chambers
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.|Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Yii-Der Ida
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.affiliation: Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Cooper
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Danesh
authors.affiliation: Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Dedoussis
authors.affiliation: Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: de Faire
authors.affiliation: Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Feranil
authors.affiliation: Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrières
authors.affiliation: Clinical Research Branch, National Institute Health, Baltimore, MD, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA.|Department of Psychiatry, University of California, Los Angeles, USA.
authors.forename: Nelson B
authors.initials: NB
authors.lastname: Freimer
authors.affiliation: Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.affiliation: Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden.|Department of Medicine, Helsinki University Hospital, FI-00029 Helsinki, Finland.
authors.forename: Leif C
authors.initials: LC
authors.lastname: Groop
authors.affiliation: Icelandic Heart Association, Kopavogur, Iceland.
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Gyllensten
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.|Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.|Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Hamsten
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.affiliation: Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
authors.forename: Aroon
authors.initials: A
authors.lastname: Hingorani
authors.affiliation: Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.|Division of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.|Division of Genetics, Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
authors.affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.|Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: G Kees
authors.initials: GK
authors.lastname: Hovingh
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Chao Agnes
authors.initials: CA
authors.lastname: Hsiung
authors.affiliation: Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom.
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
authors.affiliation: Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.affiliation: HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
authors.forename: Kristian
authors.initials: K
authors.lastname: Hveem
authors.affiliation: Kaiser Permanente, Division of Research, Oakland, CA, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Iribarren
authors.affiliation: Biocenter Oulu, University of Oulu, Oulu, Finland.|Institute of Health Sciences, University of Oulu, Finland.|Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK.|National Institute for Health and Welfare, Oulu, Finland.|Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Järvelin
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Jula
authors.affiliation: Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Hjelt Institute, Department of Public Health, University of Helsinki, Finland.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.affiliation: Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.
authors.forename: Antero
authors.initials: A
authors.lastname: Kesäniemi
authors.affiliation: Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom.
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimaki
authors.affiliation: Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom.|Imperial College Healthcare NHS Trust, London, United Kingdom.|National Heart & Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom.
authors.forename: Jaspal S
authors.initials: JS
authors.lastname: Kooner
authors.affiliation: Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Koudstaal
authors.affiliation: Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA.
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Krauss
authors.affiliation: MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom.
authors.forename: Diana
authors.initials: D
authors.lastname: Kuh
authors.affiliation: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Kuusisto
authors.affiliation: Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark.|Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
authors.forename: Kirsten O
authors.initials: KO
authors.lastname: Kyvik
authors.affiliation: Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
authors.affiliation: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Lakka
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Lindgren
authors.affiliation: Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.affiliation: Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany.|Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.|Synlab Academy, Synlab Services GmbH,Gottlieb-Daimler-Straße 25, 68165 Mannheim, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: März
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.|Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom.
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.affiliation: Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
authors.forename: Colin A
authors.initials: CA
authors.lastname: McKenzie
authors.affiliation: U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Meneton
authors.affiliation: Estonian Genome Center of the University of Tartu, Tartu, Estonia.|Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
authors.forename: Andres
authors.initials: A
authors.lastname: Metspalu
authors.affiliation: Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Leena
authors.initials: L
authors.lastname: Moilanen
authors.affiliation: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morris
authors.affiliation: Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.|Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK.
authors.forename: Patricia B
authors.initials: PB
authors.lastname: Munroe
authors.affiliation: Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
authors.forename: Inger
authors.initials: I
authors.lastname: Njølstad
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Pedersen
authors.affiliation: Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Power
authors.affiliation: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany.|Department of Neurology, General Central Hospital, Bolzano, Italy.|Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
authors.affiliation: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom.
authors.forename: Jackie F
authors.initials: JF
authors.lastname: Price
authors.affiliation: Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.|Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Quertermous
authors.affiliation: Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Rainer
authors.initials: R
authors.lastname: Rauramaa
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.|Center for Non-Communicable Diseases, Karachi, Pakistan.|Department of Medicine, University of Pennsylvania, USA.
authors.forename: Danish
authors.initials: D
authors.lastname: Saleheen
authors.affiliation: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.affiliation: Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Dharambir K
authors.initials: DK
authors.lastname: Sanghera
authors.affiliation: South Karelia Central Hospital, Lappeenranta, Finland.
authors.forename: Jouko
authors.initials: J
authors.lastname: Saramies
authors.affiliation: Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.|Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany.
authors.forename: Peter E H
authors.initials: PEH
authors.lastname: Schwarz
authors.affiliation: Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Wayne H-H
authors.initials: WH
authors.lastname: Sheu
authors.affiliation: Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland.|Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Shuldiner
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.|Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.|Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Agneta
authors.initials: A
authors.lastname: Siegbahn
authors.affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
authors.affiliation: deCODE Genetics/Amgen, 101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland.
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
authors.affiliation: Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
authors.forename: David P
authors.initials: DP
authors.lastname: Strachan
authors.affiliation: Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA.
authors.forename: Bamidele O
authors.initials: BO
authors.lastname: Tayo
authors.affiliation: Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Tremoli
authors.affiliation: Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.|Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.|King Abdulaziz University, Faculty of Medicine, Jeddah 21589, Saudi Arabia.|Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.|Research Unit, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Uusitupa
authors.affiliation: Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.|Centre for Medical Systems Biology, Leiden, the Netherlands.
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.affiliation: Department of Medicine, Lausanne University Hospital, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Vollenweider
authors.affiliation: Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.|Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Wallentin
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.affiliation: Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia.
authors.forename: John B
authors.initials: JB
authors.lastname: Whitfield
authors.affiliation: LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands.|Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Bruce H R
authors.initials: BHR
authors.lastname: Wolffenbuttel
authors.affiliation: Department of Cardiovascular Epidemiology and Population Genetics, National Center for rdiovascular Investigation, Madrid, Spain.|IMDEA-Alimentacion, Madrid, Spain.|Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
authors.affiliation: Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom.
authors.forename: Colin N A
authors.initials: CNA
authors.lastname: Palmer
authors.affiliation: deCODE Genetics/Amgen, 101 Reykjavik, Iceland.|Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland.
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA.|Harvard Medical School, Boston MA 02115, USA.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.affiliation: Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.affiliation: Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden.|Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden.|Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Franks
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland.|Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Samuli
authors.initials: S
authors.lastname: Ripatti
authors.affiliation: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.|Framingham Heart Study, Framingham, MA, USA.
authors.forename: L Adrienne
authors.initials: LA
authors.lastname: Cupples
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.|Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Sandhu
authors.affiliation: Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Boehnke
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom.
authors.forename: Panos
authors.initials: P
authors.lastname: Deloukas
authors.affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA.|Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kathiresan
authors.affiliation: Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Mohlke
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.|Science for Life Laboratory, Uppsala University, Uppsala, Sweden.|Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.
authors.forename: Erik
authors.initials: E
authors.lastname: Ingelsson
authors.affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Gonçalo R
authors.initials: GR
authors.lastname: Abecasis
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood* / Q000235:genetics*; D014280:Triglycerides / Q000097:blood / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides