title: Histopathologic manifestations of drug-induced hepatotoxicity.
abstract: Drug-induced hepatotoxicity is underrecognized but increasingly identified as causing acute and chronic liver disease. Several prescription drugs, over-the-counter medications, dietary and/or supplementary agents, and herbal products are hepatotoxic. Drug-induced liver injury mimics other primary acute and chronic liver diseases and it should be considered in patients with hepatobiliary disease. Certain drugs result in specific histopathologic patterns of liver injury, which may help in sorting out the responsible drug. The diagnosis of drug-induced hepatotoxicity is challenging. It involves excluding other possible causes, careful medication history, the latent period between drug exposure and symptom onset and/or abnormal liver tests, and histopathologic findings.
authors.affiliation: Department of Pathology, VA Connecticut Health System and Yale University School of Medicine, 310 Cedar Street, LH 108, New Haven, CT 06516, USA. Electronic address: xuchen.zhang@yale.edu.
authors.forename: Xuchen
authors.initials: X
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Ouyang
authors.forename: Swan N
authors.initials: SN
authors.lastname: Thung
mesh_terms: D001241:Aspirin / Q000009:adverse effects; D016923:Cell Death / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D001241:Aspirin
keywords: Drug-induced hepatotoxicity; Drugs; Liver injury; Pathology