title: A foot in the door: how the chromatin modifier Brg1 and Pax6 jointly potentiate adult neurogenesis.
abstract: Transcription factors and chromatin modifiers are known to contribute to cell specification. However, whether and how they jointly act is poorly understood. In this issue of Cell Stem Cell, Ninkovic et al. show that Pax6 and Brg1 cooperate to modulate gene expression in order to direct neurogenic fate in the olfactory bulb.
authors.affiliation: Neuroscience Institute, Smilow Neuroscience Program, Department of Neuroscience and Physiology, New York University, New York, NY 10016, USA.
authors.forename: Xavier H
authors.initials: XH
authors.lastname: Jaglin
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism*; D000818:Animals; D005136:Eye Proteins / Q000378:metabolism*; D053263:Gene Regulatory Networks; D018398:Homeodomain Proteins / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; C000605732:Pax6 protein, mouse; D012097:Repressor Proteins; C491090:Smarcc1 protein, mouse; D014157:Transcription Factors