title: Imino-phosphine palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents.
abstract: The imino-phosphine ligands L1 and L2 were prepared via condensation reaction of 2-(diphenylphosphino)benzaldehyde with substituted anilines and obtained in very good yields. An equimolar reaction of L1 and L2 with either PdCl2(cod) or PtCl2(cod) gave new palladium(II) and platinum(II) complexes 1-4. The compounds were characterized by elemental analysis, IR, (1)H and (31)P NMR spectroscopy. The molecular structures of 2, 3 and 4 were confirmed by X-ray crystallography. All the three molecular structures crystallized in monoclinic C2/c space system. The coordination geometry around the palladium and platinum atoms in respective structures exhibited distorted square planar geometry at the metal centers. The complexes were evaluated in vitro for their cytotoxic activity against human breast (MCF-7) and human colon (HT-29) cancer cells, and they exhibited growth inhibitory activities and selectivity that were superior to the standard compound cisplatin.
authors.affiliation: Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa. Electronic address: wmotswainyana@uwc.ac.za.
authors.forename: William M
authors.initials: WM
authors.lastname: Motswainyana
authors.forename: Martin O
authors.initials: MO
authors.lastname: Onani
authors.forename: Abram M
authors.initials: AM
authors.lastname: Madiehe
authors.forename: Morounke
authors.initials: M
authors.lastname: Saibu
authors.forename: Ntevheleni
authors.initials: N
authors.lastname: Thovhogi
authors.forename: Roger A
authors.initials: RA
authors.lastname: Lalancette
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010720:Phosphines; D010984:Platinum; D010165:Palladium
keywords: Antitumor; Imino-phosphine; Molecular structures; Palladium; Platinum; Synthesis