title: Dietary phosphate: the challenges of exploring its role in FGF23 regulation.
abstract: Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate homeostasis, yet efforts to control its circulating levels by manipulating dietary phosphate intake in humans and animals with normal or impaired kidney function have yielded conflicting results. In the study by Zhang et al., severe phosphate restriction in a genetic mouse model of progressive kidney dysfunction failed to cause a uniform FGF23 reduction, again highlighting the complexity of FGF23 regulation.
authors.affiliation: 1] Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA [2] Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Christov
authors.forename: Harald
authors.initials: H
authors.lastname: Jüppner
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000503:physiopathology*; D000818:Animals; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D009394:Nephritis, Hereditary / Q000378:metabolism*; D010710:Phosphates / Q000008:administration & dosage* / Q000172:deficiency*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23