title: Putative drug targets in Rhizopus oryzae: in-silico insight.
abstract: Opportunistic fungal infections, such as zygomycosis, often associated with excessive morbidity and mortality, are increasingly becoming a source of concern worldwide. In the reported investigation, genome analysis of a major opportunistic fungus Rhizopus oryzae was undertaken to identify gene or protein sequences that may serve as targets for therapeutic interventions. Using database of essential genes six proteins were identified. These proteins are implicated in metabolic/cellular pathways, which are more likely to be crucial for target organism's viability. Their utility as potential drug targets is discussed.
authors.affiliation: Department of Biotechnology, Jaypee Institute of Information Technology, A-10 Sector- 62, Noida, Uttar Pradesh 201307, India.
authors.forename: Chakresh Kumar
authors.initials: CK
authors.lastname: Jain
authors.forename: Ankita
authors.initials: A
authors.lastname: Dasgupta
authors.forename: Naina
authors.initials: N
authors.lastname: Taneja
authors.forename: Sonal
authors.initials: S
authors.lastname: Chaubey
authors.forename: Reema
authors.initials: R
authors.lastname: Gabrani
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
mesh_terms: D003198:Computer Simulation; D030541:Databases, Genetic; D030562:Databases, Protein; D005656:Fungal Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D016681:Genome, Fungal; D053858:Metabolic Networks and Pathways / Q000235:genetics; D058990:Molecular Targeted Therapy; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology; D012233:Rhizopus / Q000235:genetics*
chemical_list: D005656:Fungal Proteins
keywords: DEG; Rhizopus oryzae; bioinformatics; drug targets; gene sequences; genome analysis; opportunistic fungal infections; protein sequences; riboflavin synthesis pathway; therapeutic intervention; zygomycosis