title: Chemotherapy of glioblastoma by targeted liposomal platinum compounds with focused ultrasound.
abstract: Giloblastoma multiforme (GBM) is the most aggressive brain neoplasm, and patients have a poor prognosis after radiation and chemotherapy. The chemotherapy protocols still marginally improve the anti-tumor effect of patients with glioblastoma because the therapeutic dosage of many drugs is impeded by the blood-brain barrier (BBB). The use of liposomal drugs to GBM treatment might benefit from a more crossing of the BBB due to the lipid nature achieving higher doses of drug at the tumor sites. Human GBM-bearing mice were injected intravenously with cisplatin encapsulated in atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes or unconjugated liposome. Moreover, the administration of AP-1 liposomal cisplatin (lipoplatin) followed by focused ultrasound (FUS)-induced BBB disruption. Tumor progression was monitored by biophotonic imaging. The preliminary data demonstrated that the GBM chemotherapy with AP-1 lipoplatin followed by pulsed FUS showed a modest improvement of tumor growth in the brain compared to the group treated with lipoplatin alone. Further investigations are needed to use this new targeted lipoplatin in treatment of malignancies.
authors.forename: Feng-Yi
authors.initials: FY
authors.lastname: Yang
authors.forename: Shih-Cheng
authors.initials: SC
authors.lastname: Horng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001812:Blood-Brain Barrier / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010455:Peptides / Q000737:chemistry; D014183:Transplantation, Heterologous
chemical_list: C513345:AP1 peptide; D000970:Antineoplastic Agents; D008081:Liposomes; D010455:Peptides; C503131:lipoplatin; D002945:Cisplatin