title: Topical tranexamic acid reduces transfusion rates in total hip and knee arthroplasty.
abstract: The efficaciousness of topical tranexamic acid use at the end of knee arthroplasty surgery to reduce blood loss and transfusion requirements has previously been shown. The aim of this study was to retrospectively assess the effectiveness of topical tranexamic acid use, comparing 155 patients undergoing hip and knee arthroplasty surgery in which tranexamic acid was routinely used, to a group of 149 patients from a similar time frame prior to the introduction of tranexamic acid use. The transfusion rate fell from 19.3% to 2.3% for hip arthroplasty patients and from 13.1% to 0% for knee arthroplasty patients; these differences were significant. We also found significant reductions in haemoglobin loss, blood loss and length of stay of 8 g/L, 244 mL and 1.0 days respectively for hip arthroplasties and 15 g/L, 527 mL and 1.2 days respectively for knee arthroplasties following the introduction of tranexamic acid.
authors.affiliation: Division of Orthopaedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Julian
authors.initials: J
authors.lastname: Gilbody
authors.affiliation: Division of Orthopaedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Herman S
authors.initials: HS
authors.lastname: Dhotar
authors.affiliation: Division of Orthopaedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Perruccio
authors.affiliation: Division of Orthopaedic Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: J Roderick
authors.initials: JR
authors.lastname: Davey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D012189:Retrospective Studies; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid
keywords: arthroplasty; blood loss; blood transfusion; surgical; tranexamic acid