title: Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications.
abstract: We report a simple method to fabricate multifunctional polyelectrolyte thin films to load and deliver the therapeutic drugs. The multilayer thin films were assembled by the electrostatic adsorption of poly (allylamine hydrochloride) (PAH) and dextran sulfate (DS). The silver nanoparticles (Ag NPs) biosynthesized from novel Hybanthus enneaspermus leaf extract as the reducing agent were successfully incorporated into the film. The biosynthesized Ag NPs showed excellent antimicrobial activity against the range of enteropathogens, which could be significantly enhanced when used with commercial antibiotics. The assembled silver nano composite multilayer films showed rupture and deformation when they are exposed to laser. The Ag NPs act as an energy absorption center, locally heat up the film and rupture it under laser treatment. The antibacterial drug, moxifloxacin hydrochloride (MH) was successfully loaded into the multilayer films. The total amount of MH release observed was about 63% which increased to 85% when subjected to laser light exposure. Thus, the polyelectrolyte thin film reported in our study has significant potential in the field of remote activated drug delivery, antibacterial coatings and wound dressings.
authors.affiliation: SRM Research Institute, SRM University, Kattankulathur, Chennai 603 203, Tamil Nadu, India; Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: Jaganathan
authors.initials: J
authors.lastname: Sripriya
authors.forename: Sundaramurthy
authors.initials: S
authors.lastname: Anandhakumar
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Achiraman
authors.forename: Jacob Joe
authors.initials: JJ
authors.lastname: Antony
authors.forename: Durairaj
authors.initials: D
authors.lastname: Siva
authors.forename: Ashok M
authors.initials: AM
authors.lastname: Raichur
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001372:Aza Compounds / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D016264:Dextran Sulfate / Q000737:chemistry; D016503:Drug Delivery Systems; D004917:Erythromycin / Q000737:chemistry / Q000494:pharmacology; D024841:Fluoroquinolones; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry*; D000077266:Moxifloxacin; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves; D011073:Polyamines / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D029649:Violaceae
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D010936:Plant Extracts; D011073:Polyamines; D011804:Quinolines; C063994:polyallylamine; D012834:Silver; D004917:Erythromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D016264:Dextran Sulfate; D000077266:Moxifloxacin
keywords: Antimicrobicidal; Drug carriers; Hybanthus enneaspermus; Laser responsive; Moxifloxacin hydrochloride; Polyelectrolyte thin films