title: ACE-inhibitor induced angio-oedema treated with complement C1-inhibitor concentrate.
abstract: ACE-inhibitor is an antihypertensive drug which is increasingly used to treat a wide range of medical conditions. A known adverse reaction is angio-oedema of the head and neck, which can become fatal when the upper airway is involved, causing asphyxia. We present a Caucasian man, who developed severe angio-oedema of the tongue and floor of the mouth. He was successfully treated with complement C1-concentrate causing the swelling to regress within 20 min. This treatment option can be an effective alternative to bradykinin antagonists, which might not be available in the emergency room, or more invasive measures like intubation or emergency airway puncture.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Koege Hospital, Koege, Denmark.
authors.forename: Eva Rye
authors.initials: ER
authors.lastname: Rasmussen
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003172:Complement C1 / Q000037:antagonists & inhibitors*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010160:Palate, Soft; D014059:Tongue
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003172:Complement C1; C065679:icatibant; D001920:Bradykinin