title: Treatment of localized sarcomas.
abstract: Surgery remains the only potentially curative therapy in the management of localized adult soft tissue sarcomas and gastrointestinal stromal tumors. There are over 50 different unique histologic types of soft tissue sarcomas, with different patterns of recurrence and prognosis. Surgical principles and sensitivity to locoregional and systemic treatments vary considerably based on the histologic type and anatomic location, as discussed in detail in this review.
authors.affiliation: Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan 20133, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gronchi
authors.forename: Chandrajit P
authors.initials: CP
authors.lastname: Raut
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000601:surgery; D006801:Humans; D009367:Neoplasm Staging; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy*
keywords: Chemotherapy; GIST; Outcome; Radiation therapy; Sarcoma; Surgery; Survival; Tyrosine kinase inhibitors