title: [Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF--a case report].
abstract: A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T2-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε2, GluRδ2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.
authors.affiliation: Department of Neurology, Ota Memorial Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fujii
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kubo
authors.forename: Taijun
authors.initials: T
authors.lastname: Yunoki
authors.forename: Kouta
authors.initials: K
authors.lastname: Sato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
mesh_terms: D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D001932:Brain Neoplasms / Q000150:complications* / Q000276:immunology*; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms / Q000150:complications*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D017981:Receptors, Neurotransmitter / Q000276:immunology; D013702:Temporal Lobe; D013724:Teratoma / Q000150:complications*
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C069474:glutamine receptor