title: tert-Butyl 4-{[2-amino-4-(2-hy-droxy-phen-yl)pyrimidin-5-yl]meth-yl}piperazine-1-carboxyl-ate.
abstract: In the title compound, C20H27N5O3, the central piperazine ring adopts a chair conformation, with the N-bound carboxyl-ate and methyl-ene substituents occupying bis-ectional and equatorial orientations, respectively. A twist is evident between the aromatic rings [dihedral angle = 25.61 (9)°] but an intra-molecular O-H⋯N hydrogen bond persists between these. Supra-molecular tapes along [1-10] are formed in the crystal packing through N(amino)-H⋯O(hydrox-yl) and N(amino)-H⋯N(pyrimidin-yl) hydrogen bonds, and these are linked into layers in the ab plane by π-π inter-actions [inter-centroid distance between pyrimidinyl rings = 3.5919 (9) Å].
authors.affiliation: P. S. Science and H. D. Patel Arts College, S. V. Campus, Kadi, Gujarat, 382 715, India.
authors.forename: Nilesh N
authors.initials: NN
authors.lastname: Gajera
authors.forename: Mukesh C
authors.initials: MC
authors.lastname: Patel
authors.forename: Mukesh M
authors.initials: MM
authors.lastname: Jotani
authors.forename: Edward R T
authors.initials: ER
authors.lastname: Tiekink