title: Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review.
abstract: Recently, Coenzyme Q10 (CoQ10) deficiency has been implicated in the pathophysiology of fibromyalgia (FM). It is our objective to present the findings of the FM evaluation before and after oral CoQ10 treatment using the American College of Rheumatology (ACR) Diagnostic Criteria of 1990 and 2010, and Symptom Checklist-Revised (Scl-90-R). Four patients with FM were examined using the trigger points, the Fibromyalgia Impact Questionnaire, visual analog scale (pain, fatigue, and sleep), Widespread Pain Index, symptom severity scale, and Scl-90-R. Previously, CoQ10 contents from patients were analyzed by high-performance liquid chromatography. All patients showed CoQ10 deficiency. All patients meet the ACR 1990 and 2010 criteria. After treatment, all patients showed an important improvement in clinical symptoms in all evaluation methods. According to our results, and evaluated by three methods, patients with FM are candidates for treatment with CoQ10. However, more controlled clinical trials and investigations are needed to clarify the precise mechanism(s) by which CoQ10 may contribute in pathological and therapeutic processes of FM and to provide data on its effectiveness in FM.
authors.affiliation: Department of Normal and pathological Cytology and Histology, School of Medicine. University of Seville, Seville, Spain.
authors.forename: Elísabet
authors.initials: E
authors.lastname: Alcocer-Gómez
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Cano-García
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
mesh_terms: D000328:Adult; D000368:Aged; D001259:Ataxia / Q000150:complications / Q000188:drug therapy; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000150:complications / Q000188:drug therapy; D018908:Muscle Weakness / Q000150:complications / Q000188:drug therapy; D011795:Surveys and Questionnaires; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000172:deficiency / Q000494:pharmacology
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10
keywords: ACR criteria; Coenzyme Q10; Fibromyalgia; Scl-90R