title: Influence of peripheral artery disease and statin therapy on apolipoprotein profiles.
abstract: Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modifiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein profiles in 29 subjects with peripheral artery disease (PAD) and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein profiles of subjects with PAD either treated (n = 17) or untreated (n = 12) with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C (P < 0.05) and lower values of Lp-A-I:A-II (P < 0.05) than controls. The PAD group taking statins had lower age-adjusted values for apoB (P < 0.05), Lp-A-II:B:C:D:E (P < 0.05), Lp-B:E + Lp-B:C:E (P < 0.05), Lp-B:C (P < 0.05), and Lp-A-I (P < 0.05) than the untreated PAD group. Subjects with PAD have impaired apolipoprotein profiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk profile, particularly noted in multiple apolipoprotein subparticles. The efficacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle profile than in the more traditional lipid profile of subjects with PAD and claudication. This trial is registered with ClinicalTrials.gov NCT00618670.
authors.affiliation: Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK 73117, USA ; Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA ; University of Oklahoma Health Sciences Center, O'Donoghue Research Building, 1122 NE 13th Street, Suite 1200, Oklahoma City, OK 73117, USA.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Gardner
authors.forename: Petar
authors.initials: P
authors.lastname: Alaupovic
authors.forename: Donald E
authors.initials: DE
authors.lastname: Parker
authors.forename: Polly S
authors.initials: PS
authors.lastname: Montgomery
authors.forename: Omar L
authors.initials: OL
authors.lastname: Esponda
authors.forename: Ana I
authors.initials: AI
authors.lastname: Casanegra