title: A review of the JR blood group system.
abstract: The JR blood group system (ISBT 032) consists of one antigen,Jra, which is of high prevalence in all populations. The rare Jr(a-) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jra has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jra antigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2 gene on chromosome 4q22.1. The Jr(a-) phenotype mostly results from recessive inheritance of ABCG2 null alleles caused by frameshift or nonsense changes.
authors.affiliation: PhD (corresponding author), Professor and Researcher, Hemocentro, Unicamp, Rua Carlos Chagas 480, Campinas, SP, Brazil, 13083-870.
authors.forename: Lilian
authors.initials: L
authors.lastname: Castilho
authors.forename: Marion E
authors.initials: ME
authors.lastname: Reid
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D000483:Alleles; D001789:Blood Group Antigens / Q000097:blood / Q000235:genetics / Q000276:immunology; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics / Q000378:metabolism; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000235:genetics / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000235:genetics / Q000276:immunology; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001789:Blood Group Antigens; D007518:Isoantibodies; D009363:Neoplasm Proteins