title: Drawing a Waddington landscape to capture dynamic epigenetics.
abstract: Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided, is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.
authors.affiliation: Université de Rennes 1 IRSET U1085 Transcription, Environment and Cancer, Campus de Beaulieu, Rennes Cedex, 35042, France.
authors.forename: Floriane
authors.initials: F
authors.lastname: Nicol-Benoit
authors.forename: Pascale
authors.initials: P
authors.lastname: le Goff
authors.forename: Denis
authors.initials: D
authors.lastname: Michel
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans
chemical_list: D002843:Chromatin
keywords: epigenetics; multi-stability; steady state