title: A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology.
abstract: As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry. Because of the advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system. In addition, an on-off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology. This is pioneering work to harness the momentum of CMOS integrated technology into emerging bio-diagnosis technologies. This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM). Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for low-cost and mobile applications. As a consequence, this developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis.
authors.affiliation: Graduate Institute of Electronics Engineering, National Taiwan University, Taipei 10617, Taiwan. sslu@cc.ee.ntu.edu.tw.
authors.forename: C-W
authors.initials: CW
authors.lastname: Huang
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Huang
authors.forename: P-W
authors.initials: PW
authors.lastname: Yen
authors.forename: H-H
authors.initials: HH
authors.lastname: Tsai
authors.forename: H-H
authors.initials: HH
authors.lastname: Liao
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Juang
authors.forename: S-S
authors.initials: SS
authors.lastname: Lu
authors.forename: C-T
authors.initials: CT
authors.lastname: Lin
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004279:DNA, Viral / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008670:Metals / Q000737:chemistry; D009206:Myocardium / Q000378:metabolism; D053770:Nanowires / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D012666:Semiconductors; D012825:Silicon / Q000737:chemistry; D013696:Temperature; D019210:Troponin I / Q000032:analysis; D059015:Wireless Technology
chemical_list: D004279:DNA, Viral; D008670:Metals; D010087:Oxides; D019210:Troponin I; D012825:Silicon