title: Soft tissue angiofibroma: a case report.
abstract: Soft tissue angiofibroma is a recently described neoplasm that typically presents as a slowly growing, painless mass in the soft tissues of the lower extremities. Cytogenetic and molecular studies have identified a recurrent t(5;8) translocation. Treatment is simple excision. Existing data suggest that this tumor is benign and has a low rate of local recurrence. The radiologic and pathologic differential diagnoses for this lesion include both benign and malignant lesions, including plantar fibromatosis, tenosynovial giant cell tumor, fibroma of tendon sheath, epithelioid sarcoma, and low-grade myxofibrosarcoma. Proper identification of this benign lesion through radiologic and pathologic correlation is important to prevent misdiagnosis of a low-grade sarcoma.
authors.affiliation: Harvard Medical School, 250 Longwood Avenue, Boston, MA, 02115, USA, jonathan_lee@hms.harvard.edu.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Bredella
authors.forename: Dempsey S
authors.initials: DS
authors.lastname: Springfield
authors.forename: Gunnlauger P
authors.initials: GP
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D018322:Angiofibroma / Q000175:diagnosis* / Q000601:surgery; D005528:Foot / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome