title: Lipid sorting and multivesicular endosome biogenesis.
abstract: Intracellular organelles, including endosomes, show differences not only in protein but also in lipid composition. It is becoming clear from the work of many laboratories that the mechanisms necessary to achieve such lipid segregation can operate at very different levels, including the membrane biophysical properties, the interactions with other lipids and proteins, and the turnover rates or distribution of metabolic enzymes. In turn, lipids can directly influence the organelle membrane properties by changing biophysical parameters and by recruiting partner effector proteins involved in protein sorting and membrane dynamics. In this review, we will discuss how lipids are sorted in endosomal membranes and how they impact on endosome functions.
authors.affiliation: Biochemistry Department, University of Geneva, 1211 Geneva 4, Switzerland.
authors.forename: Christin
authors.initials: C
authors.lastname: Bissig
authors.forename: Jean
authors.initials: J
authors.lastname: Gruenberg
mesh_terms: D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism; D050356:Lipid Metabolism; D008563:Membrane Lipids; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000096:biosynthesis / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010716:Phosphatidylinositols; D010743:Phospholipids; D002784:Cholesterol