title: [The differences between the guidelines of the European Society of Cardiology and the American College of Cardiology/ American Heart Association for oral P2Y12 inhibitor therapy in the management of patients with acute coronary syndromes].
abstract: The analysis of the evidence that formed the basis for the current guidelines of the European Society of Cardiology (ESC) on oral therapy by antithrombotic drugs for acute coronary syndromes (ACS), and a comparison with the U.S. guidelines. The ESC guidelines, published during 2011-2012, declared the superiority of prasugrel and ticagrelor over clopidogrel in patients with ACS without ST elevation and myocardial infarction (MI) with ST elevation. These guidelines are based in each case on a subgroup analysis of a single study using either prasugrel (TRITON), or ticagrelor (PLATO). In contrast, the American College of Cardiology (ACC) and the American Heart Association (AHA) guidelines, published in 2012-2013, are more balanced, conservative and present evidence-based outlook, suggesting no proven extra benefit of one P2Y12 antagonist over the other(s). The ESC guidelines regarding the findings of the superiority of prasugrel or ticagrelor over clopidogrel are overly optimistic and not always evidence-based. A small frequency of clinical use of prasugrel and ticagrelor in the world in general and Europe in particular, suggests a discrepancy between the traditionally appointed treatment and published ESC guidelines.
authors.affiliation: Johns Hopkins University, Maryland, USA; FSBI Educational Scientific Medical Centre of the General Management Department of the President of RF, ul. Marshala Timoshenko 21, 121359 Moscow, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Serebruany
authors.forename: I V
authors.initials: IV
authors.lastname: Pershukov
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D000284:Administration, Oral; D001777:Blood Coagulation / Q000187:drug effects*; D002309:Cardiology; D019468:Disease Management; D005060:Europe; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000145:classification / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D058921:Purinergic P2Y Receptor Antagonists / Q000145:classification / Q000627:therapeutic use; D012955:Societies, Medical; D016019:Survival Analysis; D014481:United States
chemical_list: D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists