title: Timing and source of the maximum of the transthoracic impedance cardiogram (dZ/dt) in relation to the H-I-J complex of the longitudinal ballistocardiogram under gravity and microgravity conditions.
abstract: The transthoracic impedance cardiogram (ICG) and the acceleration ballistocardiogram (BCG) measured close to the center of mass of the human body are generated by changes of blood distribution. The transthoracic ICG is an integrated signal covering the whole thorax and spatial resolution is poor. Comparison between both signals can be used to elucidate the source of the ICG signal. We recorded the ECG, ICG, and BCG simultaneously in healthy subjects under resting and microgravity conditions during parabolic flights. The time interval between the R-peak of the ECG and the maximum of the ICG (R-dZ/dtmax) and the time interval between the R-peak of the ECG and the I-peak in the BCG (R-I) differed significantly (p<0.0001). The I-peak in the BCG always occurred earlier during systole than dZ/dtmax. The delay of dZ/dtmax ranged between 23 and 28 ms at rest and was lowest under microgravity conditions (12 ± 4 ms, p<0.02). Our results suggest that both signals have different sources. Combination of modern imaging techniques with classical non invasive approaches to detect changes of blood distribution may provide new insights into the complex interaction between blood flow and mechanocardiographic signals like the BCG.
authors.forename: E
authors.initials: E
authors.lastname: Luchitskaya
authors.forename: Q
authors.initials: Q
authors.lastname: Deliere
authors.forename: A
authors.initials: A
authors.lastname: Diedrich
authors.forename: N
authors.initials: N
authors.lastname: Pattyn
authors.forename: A
authors.initials: A
authors.lastname: Almorad
authors.forename: L
authors.initials: L
authors.lastname: Beck
authors.forename: P
authors.initials: P
authors.lastname: Gauger
authors.forename: U
authors.initials: U
authors.lastname: Limper
authors.forename: I
authors.initials: I
authors.lastname: Funtova
authors.forename: R M
authors.initials: RM
authors.lastname: Baevsky
authors.forename: P-F
authors.initials: PF
authors.lastname: Migeotte
authors.forename: J
authors.initials: J
authors.lastname: Tank
mesh_terms: D000328:Adult; D001450:Ballistocardiography / Q000295:instrumentation*; D002307:Cardiography, Impedance / Q000295:instrumentation*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D012146:Rest; D013026:Space Flight; D013599:Systole / Q000502:physiology; D013997:Time Factors; D014893:Weightlessness