title: Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene.
abstract: Inhaled corticosteroids (ICS) are one of the most commonly used asthma therapies and have highly variable treatment success. Polymorphisms in TBX21, a gene important for the biological action of corticosteroids, could be associated with treatment response in asthmatics. We genotyped for rs9910408 in TBX21 in 208 adult asthmatic patients, treated at least 3 years with ICS. Polymorphism rs9910408 was associated with response to ICS treatment. When treatment success was assessed by a decrease in bronchial hyperresponsiveness (BHR), the frequency of AA genotype was significantly higher in good responders (P = 0.049). This genotype related response was even more evident in the subgroups of non-smokers (P = 0.008) and in non-atopic patients (P = 0.009). AA genotype was overrepresented among good responders according to changes in FEV1 in the subgroups of non-smokers (P = 0.013) and in non-atopic patients (P = 0.048). Our results showed that treatment response to ICS, assessed as changes in BHR and FEV1, is associated with TBX21.
authors.affiliation: Outpatient practice for pulmonary diseases and allergy, Murska Sobota, Slovenia.
authors.forename: Anton
authors.initials: A
authors.lastname: Lopert
authors.forename: Matija
authors.initials: M
authors.lastname: Rijavec
authors.forename: Mateja
authors.initials: M
authors.lastname: Zavbi
authors.forename: Peter
authors.initials: P
authors.lastname: Korošec
authors.forename: Matjaž
authors.initials: M
authors.lastname: Fležar
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D011788:Quality of Life; D012907:Smoking; D020825:T-Box Domain Proteins / Q000235:genetics*; D016896:Treatment Outcome; D000098815:T-bet Transcription Factor
chemical_list: D000305:Adrenal Cortex Hormones; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor