title: Intravenous thrombolysis for ischemic stroke in recurrent oligodendroglioma: a case report.
abstract: Data on efficacy and safety of intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rtPA) in patients with acute ischemic stroke (AIS) and intracranial neoplasm are lacking. To date, only a handful of case reports have been published in the literature addressing the administration of IV rtPA to patients with AIS and coexisting brain neoplasms. We present the case of successful IV thrombolysis with rtPA for AIS in a patient with oligodendroglioma on bevacizumab without hemorrhagic complications. We summarize the published cases of thrombolysis in AIS in patients with intracranial neoplasms.
authors.affiliation: Department of Neurology, NorthShore University Health System, Evanston, Illinois; Department of Neurology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois. Electronic address: rdafer@northshore.org.
authors.forename: Rima M
authors.initials: RM
authors.lastname: Dafer
authors.affiliation: Department of Neurology, Rush Medical Center, Chicago, Illinois.
authors.forename: Nina
authors.initials: N
authors.lastname: Paleologos
authors.affiliation: Department of Neurology, NorthShore University Health System, Evanston, Illinois.
authors.forename: Deborah
authors.initials: D
authors.lastname: Lynch
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000068258:Bevacizumab; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009837:Oligodendroglioma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011994:Recombinant Proteins / Q000008:administration & dosage; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D000068258:Bevacizumab; C067262:PLAT protein, human; D010959:Tissue Plasminogen Activator
keywords: Thrombolysis; brain tumors; ischemic stroke; oligodendroglioma