title: Successful surgical repair of acute type A aortic dissection without the use of blood products.
abstract: We report successful surgical treatment of type A aortic dissection in a Jehovah's Witness without the use of any blood products. An interposition graft replacement of the ascending aorta was carried out. This was under right axillo-atrial cardiopulmonary bypass with antegrade cerebral perfusion via right a subclavian and left carotid cannula for 24 minutes at 28°C. Body temperature was kept at 32°C throughout. Autologous transfusion was deployed using cell salvage and a preoperative haemodilution technique. The patient was given tranexamic acid, desmopressin, recombinant factor VIIa, folic acid and epoetin alfa. Patients who object to transfusion represent a significant challenge, especially those who are at a high risk of coagulopathy associated with inherent aortic dissection leading to perturbed haemodynamics, cardiopulmonary bypass and hypothermic circulatory arrest. Type A aortic dissection repair is possible in patients refusing the use of blood products with blood salvage techniques and synthetic products that can limit the risk of bleeding. Minimal hypothermia is vital to preserve platelet function and avoid coagulopathy. Thus, a combination of normothermic/minimal hypothermia and antegrade cerebral protection with a blood conservation strategy can be deployed for a successful surgical outcome in aortic dissection without transfusion.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, UK.
authors.forename: N
authors.initials: N
authors.lastname: Papalexopoulou
authors.forename: R Q
authors.initials: RQ
authors.lastname: Attia
authors.forename: V N
authors.initials: VN
authors.lastname: Bapat
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology; D016913:Blood Component Transfusion; D002637:Chest Pain / Q000209:etiology; D006801:Humans; D033221:Jehovah's Witnesses; D008297:Male; D014057:Tomography, X-Ray Computed; D016312:Treatment Refusal