title: ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury.
abstract: OBJECTIVE
  Post-traumatic epilepsy (PTE) is a serious complication of traumatic brain injury (TBI). This study is designed to determine the feasibility of using multiparametric MRI endpoints to predict differences in seizure susceptibility after experimental TBI.
  
  
  METHODS
  MRI imaging and behavioral measurements were performed at multiple time points after lateral fluid percussion injury (FPI) in rats. Seizure susceptibility was determined by video-electroencephalogram (EEG) monitoring and off-line signal analysis after chemoconvulsant challenge.
  
  
  RESULTS
  Multiple MRI endpoints, including measures of injury-related brain swelling (normalized interhemispheric volume difference, NIVD) and T1-weighted signal change with contrast enhancement (a measure of blood-brain barrier disruption, BBBD), reliably distinguished between injured and sham-injured animals at 72 hours after injury. ADC (apparent diffusion coefficient) values (a measure of water diffusivity) in injured cortex at 72 hours and 1 week after injury, BBBD in injured cortex at 72 hours after injury and NIVD at 72 hours after injury were significantly correlated with EEG-based measures of seizure susceptibility to chemoconvulsant challenge at 3 months after injury.
  
  
  CONCLUSIONS
  The correlations between our MRI quantitative endpoints and EEG-based measures of seizure susceptibility to chemoconvulsant challenge in injured animals versus sham-injured animals support the feasibility of these MRI endpoints as potential biomarkers for post-traumatic epileptogenesis.
authors.forename: Lauren
authors.initials: L
authors.lastname: Frey
authors.forename: Aaron
authors.initials: A
authors.lastname: Lepkin
authors.forename: Alyssa
authors.initials: A
authors.lastname: Schickedanz
authors.forename: Kendra
authors.initials: K
authors.lastname: Huber
authors.forename: Mark S
authors.initials: MS
authors.lastname: Brown
authors.forename: Natalie
authors.initials: N
authors.lastname: Serkova
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D001929:Brain Edema / Q000473:pathology; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D003292:Convulsants; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004569:Electroencephalography; D004834:Epilepsy, Post-Traumatic / Q000175:diagnosis* / Q000473:pathology; D007608:Kainic Acid; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D003292:Convulsants; D007608:Kainic Acid
keywords: Epileptogenesis,; Fluid percussion injury,; Kainate,; MRI,; Post-traumatic epilepsy