title: Sulfur-assisted domino access to bicyclic dihydrofurans: case study and early synthetic applications.
abstract: A DDQ-mediated domino reaction (up to six steps in a single process) has been developed to selectively provide substituted dihydrofurans from a common starting material containing a cyclic bis-thioenol ether. Study of the reaction mechanism highlighted a role played by the sulfur-containing moiety in influencing reaction rate and stereoselectivity.
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia 21, I-80126 Napoli, Italy. dandalonzo@unina.it guaragna@unina.it.
authors.forename: Concetta
authors.initials: C
authors.lastname: Paolella
authors.forename: Daniele
authors.initials: D
authors.lastname: D'Alonzo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palumbo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Guaragna
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013455:Sulfur / Q000737:chemistry*
chemical_list: D001643:Bridged Bicyclo Compounds; D005663:Furans; C073812:2,3-dihydrofuran; D013455:Sulfur