title: Marseillevirus adenitis in an 11-month-old child.
abstract: A Marseillevirus (giant virus of amoeba) has been found in the blood and stool samples of individuals who otherwise appear to be healthy. During an attempt to define a serological cutoff for Marseillevirus by enzyme-linked immunosorbent assay (ELISA) in children, we serendipitously detected high antibody responses to Marseillevirus in an 11-month-old boy suffering from adenitis. Marseillevirus DNA was then found in his blood using PCR and with a unique sequence. We identified Marseillevirus in a lymph node using fluorescence in situ hybridization (FISH) and immunohistochemistry, and the lymph node was removed surgically. The child was declared to be cured 1 year later. We conclude that adenitis during early childhood may be caused by Marseillevirus.
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Faculté de Médecine, CNRS UMR 7278, IRD 198, Aix-Marseille Université, Marseille, France.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Popgeorgiev
authors.forename: Gerard
authors.initials: G
authors.lastname: Michel
authors.forename: Hubert
authors.initials: H
authors.lastname: Lepidi
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.forename: Christelle
authors.initials: C
authors.lastname: Desnues
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004266:DNA Virus Infections / Q000175:diagnosis* / Q000821:virology*; D004267:DNA Viruses / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000097:blood / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008198:Lymph Nodes / Q000821:virology; D008199:Lymphadenitis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D008297:Male; D008853:Microscopy; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral