title: Habituation of steady-state visual evoked potentials in response to high-frequency polychromatic foveal visual stimulation.
abstract: In an attempt to develop safe and robust methods for monitoring migraineurs' brain states, we explores the feasibility of using white, red, green and blue LED lights flickering around their critical flicker fusion (CFF) frequencies as foveal visual stimuli for inducing steady-state visual evoked potentials (SSVEP) and causing discernible habituation trends. After comparing the habituation indices, the multi-scale entropies and the time dependent intrinsic correlations of their SSVEP signals, we reached a tentative conclusion that sharp red and white light pulses flickering barely above their CFF frequencies can replace commonly used 13Hz stimuli to effectively cause SSVEP habituation among normal subjects. Empirical results showed that consecutive short bursts of light can produce more consistent responses than a single prolonged stimulation. Since these high frequency stimuli do not run the risk of triggering migraine or seizure attacks, further tests of these stimuli on migraine patients are warranted in order to verify their effectiveness.
authors.forename: Heng-Yuan
authors.initials: HY
authors.lastname: Kuo
authors.forename: George C
authors.initials: GC
authors.lastname: Chiu
authors.forename: John K
authors.initials: JK
authors.lastname: Zao
authors.forename: Kuan-Lin
authors.initials: KL
authors.lastname: Lai
authors.forename: Allen
authors.initials: A
authors.lastname: Gruber
authors.forename: Yu-Yi
authors.initials: YY
authors.lastname: Chien
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Chou
authors.forename: Chih-Kai
authors.initials: CK
authors.lastname: Lu
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Liu
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Huang
authors.forename: Albert C
authors.initials: AC
authors.lastname: Yang
authors.forename: Yijun
authors.initials: Y
authors.lastname: Wang
authors.forename: Fang-Cheng
authors.initials: FC
authors.lastname: Lin
authors.forename: Yi-Pai
authors.initials: YP
authors.lastname: Huang
authors.forename: Shuu-Jiun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Tzyy-Ping
authors.initials: TP
authors.lastname: Jung
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual / Q000528:radiation effects*; D005260:Female; D005584:Fovea Centralis / Q000502:physiology* / Q000528:radiation effects*; D006185:Habituation, Psychophysiologic / Q000528:radiation effects*; D006801:Humans; D008027:Light; D008297:Male; D010775:Photic Stimulation; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult