title: Electrical impedance spectroscopy as electrical biopsy for monitoring radiation sequelae of intestine in rats.
abstract: Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.
authors.affiliation: Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan.
authors.forename: Pei-Ju
authors.initials: PJ
authors.lastname: Chao
authors.forename: Eng-Yen
authors.initials: EY
authors.lastname: Huang
authors.forename: Kuo-Sheng
authors.initials: KS
authors.lastname: Cheng
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Huang
mesh_terms: D000818:Animals; D001706:Biopsy; D058266:Dielectric Spectroscopy; D017097:Electric Impedance; D007422:Intestines / Q000528:radiation effects*; D008297:Male; D012372:ROC Curve; D051381:Rats