title: The tooth -- a treasure chest of stem cells.
abstract: Mesenchymal stem cells can be obtained with ease from dental/oral tissue, making them an attractive source of autologous stem cells. They offer a biological solution for restoring damaged dental tissues such as vital pulp engineering, regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants. Dental mesenchymal stem cells share properties with mesenchymal stem cells from bone marrow and there is a considerable potential for these cells to be used in different stem-cell-based therapies, such as bone and muscle regeneration. In addition, their immunosuppressive-immunomodulatory properties make these cells a suitable source for treating immunodisorders like systematic lupus erythematosus. In addition, gingival tissue might also be a very good source of epithelial cells used in the treatment of severe ocular surface disorders. Being such an accessible source for different stem cells, the tooth and the attached gingival tissue (usually discarded in the clinics) represent an ideal source of autologous or allogeneic stem cells that can be used in the treatment of many clinical conditions in dentistry and medicine.
authors.affiliation: 1] Department of Craniofacial Development and Stem Cell Biology, King's College London Dental Institute, Tower Wing, Guy's Hospital, London Bridge, London, SE1 9RT [2] NIHR GSTT/KCL Comprehensive Biomedical Research Centre.
authors.forename: A A
authors.initials: AA
authors.lastname: Volponi
authors.forename: P T
authors.initials: PT
authors.lastname: Sharpe
mesh_terms: D003782:Dental Pulp / Q000166:cytology; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D010486:Periapical Tissue / Q000166:cytology; D010510:Periodontal Diseases / Q000628:therapy; D010513:Periodontal Ligament / Q000166:cytology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014070:Tooth / Q000166:cytology*; D014076:Tooth Diseases / Q000628:therapy; D014094:Tooth, Deciduous / Q000166:cytology