title: Early detection of cognitive impairment in the elderly based on Bayesian mining using speech prosody and cerebral blood flow activation.
abstract: With the aim of providing computer aided diagnosis of dementia, we have developed a non-invasive screening system of the elderly with cognitive impairment. In our previous research, we have studied two data-mining approaches by focusing on speech-prosody and cerebral blood flow (CBF) activation during cognitive tests. On the power of these research results, this paper presents a prosody-CBF hybrid screening system of the elderly with cognitive impairment based on a Bayesian approach. The system is constructed by SPCIR (Speech Prosody-Based Cognitive Impairment Rating) based cutoff as the 1st screening, and, as the 2nd screening, two-phase Bayesian classifier for discriminating among elderly individuals with three clinical groups: elderly individuals with normal cognitive abilities (NC), patients with mild cognitive impairment (MCI), and Alzheimer's disease (AD). This paper also reports the screening examination and discusses the cost-effectiveness and the discrimination performance of the proposed system for early detection of cognitive impairment in elderly subjects.
authors.forename: Shohei
authors.initials: S
authors.lastname: Kato
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Endo
authors.forename: Akira
authors.initials: A
authors.lastname: Homma
authors.forename: Takuto
authors.initials: T
authors.lastname: Sakuma
authors.forename: Keita
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001499:Bayes Theorem; D001794:Blood Pressure / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply*; D003072:Cognition Disorders / Q000175:diagnosis*; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019265:Spectroscopy, Near-Infrared; D013060:Speech / Q000502:physiology*