title: Can transcutaneous bilirubinometry safely guide phototherapy treatment of neonatal jaundice in Malawi?
abstract: OBJECTIVE
  To assess the correlation between total serum bilirubin (TSB) and transcutaneous bilirubin (TcB) values in Malawian newborn infants, and to investigate whether TcB can be used safely to guide phototherapy treatment in the absence of TSB results.
  
  
  METHODS
  128 newborn jaundiced infants were studied in the neonatal nursery at Queen Elizabeth Central Hospital, Blantyre. Paired TSB and TcB measurements (from forehead and sternum) were compared using the linear regression and Bland-Altman methods. Clinical decisions based on TcB results were compared with those based on 'gold standard' TSB results.
  
  
  RESULTS
  For infants not under phototherapy, the lowest TcB reading (from forehead or sternum) gave the strongest correlation with TSB: r = 0·83 for term infants and r = 0·71 for premature infants. For infants undergoing phototherapy, the highest TcB reading gave the strongest correlation with TSB: r = 0·66 for term infants and r = 0·71 for premature infants. TcB values overestimated the degree of jaundice. For infants not under phototherapy, the mean (SD) bias and imprecision of TcB was 25 (72) μmol/L for term infants and 37 (73) μmol/L for premature infants. For infants under phototherapy, the mean bias and imprecision was 30 (79) μmol/L for term infants and 44 (77) μmol/L for premature infants. For infants not under phototherapy, using the lowest TcB reading to guide treatment decisions (n = 167) had good sensitivity (91%) and specificity (90%). For infants undergoing phototherapy, using the highest TcB reading to guide treatment decisions (n = 129) had good sensitivity (94%), but lower specificity (36%).
  
  
  CONCLUSIONS
  TcB can be used to safely guide phototherapy treatment in a resource-poor setting.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rylance
authors.forename: Jennifer
authors.initials: J
authors.lastname: Yan
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Molyneux
mesh_terms: D000293:Adolescent; D000328:Adult; D001663:Bilirubin / Q000032:analysis*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy*; D008295:Malawi; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*; D015997:Neonatal Screening / Q000295:instrumentation / Q000379:methods; D010789:Phototherapy; D011247:Pregnancy; D012867:Skin / Q000473:pathology*; D055815:Young Adult
chemical_list: D001663:Bilirubin
keywords: Bedside technology,; Bilirubin,; Hyperbilirubinaemia,; JM-103 jaundice meter; Less developed countries,; Newborn jaundice,; Transcutaneous bilirubin measurement,