title: Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice.
abstract: This study investigated the anti-obesity effects of honeysuckle anthocyanins (HA) in a high fat diet-induced mouse model. The mice were initially fed with a low-fat diet (LFD) or high-fat diet (HFD) for 8 weeks. After that, the HFD-fed mice were divided into five groups, with 12 mice in each group, including a HFD group, a HFD plus Orlistat group, and three HFD plus HA (at a dose of 50, 100, or 200 mg kg(-1)) groups, for another 8-week experiment. HA at 100 or 200 mg kg(-1) can suppress body weight gain, reduce serum and liver lipid profiles, ameliorate impaired hepatic function, and significantly increase serum adiponectin concentration while decreasing serum insulin and leptin levels. These results suggest that the anti-obesity effect of HA might be through the blockage of lipid accumulation.
authors.affiliation: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China. zjuchenwei@zju.edu.cn xdzheng@zju.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Zhuoping
authors.initials: Z
authors.lastname: Yu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Tang
authors.forename: Haizhao
authors.initials: H
authors.lastname: Song
authors.forename: Zichun
authors.initials: Z
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000737:chemistry; D019440:Anti-Obesity Agents / Q000008:administration & dosage* / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D019587:Dietary Supplements / Q000032:analysis; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D031239:Lonicera / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000872:Anthocyanins; D019440:Anti-Obesity Agents; D007328:Insulin; D020738:Leptin; D008055:Lipids; D010936:Plant Extracts