title: Faster metabolite (1)H transverse relaxation in the elder human brain.
abstract: (1)H magnetic resonance spectroscopy (MRS) is unique among imaging modalities because signals from several metabolites are measured during a single examination period. Each metabolite reflects a distinct intracellular process. Furthermore transverse (T2 ) relaxation times probe the viability of the cell microenvironment, e.g., the viscosity of the cellular fluids, the microscopic susceptibility distribution within the cells, and the iron content. In this study, T2s of brain metabolites were measured in the occipital lobe of eighteen young and fourteen elderly subjects at a field strength of 4 tesla. The T2s of N-acetylaspartate, total creatine, and total choline were 23%, 16% and 10% shorter in elderly than in young subjects. The findings of this study suggest that noninvasive detection of T2 provides useful biological information on changes in the cellular microenvironment that take place during aging.
authors.affiliation: Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Marjańska
authors.forename: Uzay E
authors.initials: UE
authors.lastname: Emir
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Deelchand
authors.forename: Melissa
authors.initials: M
authors.lastname: Terpstra
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D060833:Cellular Microenvironment / Q000502:physiology; D002794:Choline / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism*; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D009778:Occipital Lobe / Q000166:cytology / Q000378:metabolism*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline