title: [Effect of an educational program on effectiveness and safety of anticoagulant therapy in patients with prostheses of cardiac valves].
abstract: We analyzed effectiveness and safety of anticoagulant therapy in patients with prostheses of cardiac valves at the background of educational program and without special training. We revealed positive effect of educational program during participation in which in 80 cases (67.8%) patients determined international normalized ratio every month and in 50 of them (62,5%) level of hypocoagulation corresponded to target range (p=0.001). At the background of educational program rate of thrombotic complications was 2.73% per patient year, at the background of no educational program - 4.90% per patient year (p=0.040) while rates of hemorrhagic complications were 2.73 and 7.20% per patient year, respectively (p=0.002).
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases of SB of the RAMS, Sosnovy boul. 6, 650002 Kemerovo, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Gorbunova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Penskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Rogulina
authors.forename: S A
authors.initials: SA
authors.lastname: Maksimov
authors.forename: R R
authors.initials: RR
authors.lastname: Salakhov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Zhuravleva
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods; D016903:Drug Monitoring; D005260:Female; D057220:Health Literacy / Q000379:methods*; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D020380:Needs Assessment; D017063:Outcome Assessment, Health Care; D010353:Patient Education as Topic / Q000379:methods*; D016730:Program Development; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants