title: Comparison of careHPV and hybrid capture 2 assays for detection of high-risk human Papillomavirus DNA in cervical samples from HIV-1-infected African women.
abstract: The careHPV and HC2 assays were compared for high-risk human papillomavirus (HR-HPV) DNA detection in cervical samples from 149 HIV-1-infected African women. The HR-HPV DNA detection rates were 37.6% and 34.9% for careHPV and HC2, respectively. Agreement between the two tests was 94.6% (95% confidence interval [CI], 89.7% to 97.7%) with a kappa value of 0.88 (95% CI, 0.81 to 0.96), indicating an excellent agreement. careHPV may be considered as suitable as HC2 for cervical cancer screening among HIV-infected African women.
authors.affiliation: INSERM U1058 and University Hospital (CHU), Montpellier, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ngou
authors.forename: Mahlape P
authors.initials: MP
authors.lastname: Magooa
authors.forename: Clare
authors.initials: C
authors.lastname: Gilham
authors.forename: Florencia
authors.initials: F
authors.lastname: Djigma
authors.forename: Marie-Noelle
authors.initials: MN
authors.lastname: Didelot
authors.forename: Helen
authors.initials: H
authors.lastname: Kelly
authors.forename: Albert
authors.initials: A
authors.lastname: Yonli
authors.forename: Bernard
authors.initials: B
authors.lastname: Sawadogo
authors.forename: David A
authors.initials: DA
authors.lastname: Lewis
authors.forename: Sinead
authors.initials: S
authors.lastname: Delany-Moretlwe
authors.forename: Philippe
authors.initials: P
authors.lastname: Mayaud
authors.forename: Michel
authors.initials: M
authors.lastname: Segondy
mesh_terms: D000328:Adult; D000349:Africa; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D014773:Virology / Q000379:methods*
chemical_list: D004279:DNA, Viral