title: The stereochemical course of tricho-acorenol biosynthesis.
abstract: The biosynthesis of tricho-acorenol in Trichoderma harzianum was investigated by feeding stereospecifically deuterated mevalonolactone isotopomers, followed by a detailed GC/MS analysis of the incorporation of labelling. The results establish a highly stereospecific hydride migration and antarafacial attack of water in the terminal step towards tricho-acorenol.
authors.affiliation: Technische Universität Braunschweig, Institut für Organische Chemie, Hagenring 30, 38106 Braunschweig, Germany. j.dickschat@tu-bs.de.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Citron
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: Dickschat
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D008798:Mevalonic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism; D014242:Trichoderma / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; C015367:mevalonolactone; D008798:Mevalonic Acid