title: Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo.
abstract: We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.
authors.affiliation: University of Houston, Department of Biomedical Engineering, 4800 Calhoun Road, Houston, Texas 77004.
authors.forename: Jiasong
authors.initials: J
authors.lastname: Li
authors.forename: Shang
authors.initials: S
authors.lastname: Wang
authors.forename: Ravi Kiran
authors.initials: RK
authors.lastname: Manapuram
authors.forename: Manmohan
authors.initials: M
authors.lastname: Singh
authors.forename: Floredes M
authors.initials: FM
authors.lastname: Menodiado
authors.forename: Salavat
authors.initials: S
authors.lastname: Aglyamov
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
authors.forename: Michael D
authors.initials: MD
authors.lastname: Twa
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Larin
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology; D003315:Cornea / Q000502:physiology*; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000295:instrumentation* / Q000379:methods; D051379:Mice; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods