title: Computer-aided biophysical modeling: a quantitative approach to complex biological systems.
abstract: When dealing with the biophysics of tumors, analytical and numerical modeling tools have long been regarded as potentially useful but practically immature tools. Further developments could not just overturn this predicament, but lead to completely new perspectives in biology. Here, we give an account of our own computational tool and how we have put it to good use, and we discuss a paradigmatic example to outline a path to making cell biology more quantitative and predictive.
authors.affiliation: University of Trieste and I.N.F.N.-Sezione di Trieste, Trieste.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Milotti
authors.forename: Vladislav
authors.initials: V
authors.lastname: Vyshemirsky
authors.forename: Michela
authors.initials: M
authors.lastname: Sega
authors.forename: Sabrina
authors.initials: S
authors.lastname: Stella
authors.forename: Federico
authors.initials: F
authors.lastname: Dogo
authors.forename: Roberto
authors.initials: R
authors.lastname: Chignola
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D001696:Biomechanical Phenomena / Q000502:physiology*; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009369:Neoplasms / Q000503:physiopathology*
chemical_list: D000255:Adenosine Triphosphate; D005947:Glucose