title: Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.
abstract: BACKGROUND
  Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population.
  
  
  METHODS
  The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes.
  
  
  CONCLUSIONS
  The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.
authors.affiliation: Department of Radiation Oncology, The First People's Hospital of Xuzhou, China.
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Wu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Mi
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: An-Kang
authors.initials: AK
authors.lastname: Hu
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Qing-Guo
authors.initials: QG
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C548683:MIRN499 microRNA, human; D035683:MicroRNAs