title: The impact of a community-based clinical trial educational intervention among underrepresented Chinese Americans.
abstract: BACKGROUND
  Clinical trials are a critical resource for the discovery of new prevention, diagnostic, and treatment methods for cancer. The most effective prevention and treatment modalities are based on previous clinical trial results. However, participation in clinical trials is underrepresented by racial/ethnic minority populations, Asian Americans in particular. Asian Americans are the least represented of any ethnic groups in clinical trials. The purpose of this study is to develop and evaluate a culturally and linguistically appropriate community-based educational intervention to increase knowledge of and intent to participate in cancer clinical trials among underrepresented Chinese Americans.
  
  
  METHODS
  Community-Based Participatory Research approach was used to guide the development, cultural tailoring, implementation, and evaluation of clinical trial intervention. First, 22 Asian community representatives were recruited as community health educators (CHE) who received 12-hour training on clinical trial education. Second, 262 members were recruited from 11 Chinese community organizations. Of those recruited, a total of 247 eligible Chinese enrolled and participated in the clinical trial education delivered by trained CHEs. Participants completed pretest before and posttest after the intervention.
  
  
  RESULTS
  Fifteen of 21 measures of clinical trial knowledge showed significant changes post the intervention (P < 0.05). Education remained the sole demographic factor increasing clinical trial knowledge in multivariate analysis.
  
  
  CONCLUSIONS
  Clinical trial education should emphasize both benefits to science and the larger Asian community. This community-based clinical trial intervention demonstrated promising results and has potential to enhance recruitment and participation in clinical trial research among the underrepresented Asian Americans.
  
  
  CONCLUSIONS
  Improving clinical trial participation in the fast-growing Asian American population is key to dissemination of health innovations targeted to diminish health disparities.
authors.affiliation: Authors' Affiliations: Center for Asian Health, Department of Public Health, College of Health Professions, School of Medicine, Temple University; Asian Health Trilogy, Philadelphia, Pennsylvania; Education Network to Advance Cancer Clinical Trials (NACCT), Bethesda, Maryland; and Boston University School of Public Health, Boston, Massachusetts.
authors.forename: Grace X
authors.initials: GX
authors.lastname: Ma
authors.forename: Yin
authors.initials: Y
authors.lastname: Tan
authors.forename: Natasha C
authors.initials: NC
authors.lastname: Blakeney
authors.forename: Brenda F
authors.initials: BF
authors.lastname: Seals
authors.forename: Xiang S
authors.initials: XS
authors.lastname: Ma
authors.forename: Shumenghui
authors.initials: S
authors.lastname: Zhai
authors.forename: Amy
authors.initials: A
authors.lastname: Liu
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Tai
authors.forename: Margo
authors.initials: M
authors.lastname: Michaels
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001213:Asian; D002681:China / Q000208:ethnology; D055812:Community-Based Participatory Research / Q000379:methods*; D005260:Female; D006266:Health Education / Q000379:methods*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000208:ethnology; D010353:Patient Education as Topic / Q000379:methods*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D016896:Treatment Outcome