title: [DNA repair gene polymorphisms in ERCC4 rs6498486 and ERCC5 rs751402 and risk of salivary gland tumors].
abstract: OBJECTIVE
  To investigate the association between ERCC4 and ERCC5 polymorphisms and risk of salivary gland tumors.
  
  
  METHODS
  Case-control study was carried out in 133 cases of histologically confirmed salivary gland tumors and 142 age and gender matched healthy control cases. Polymorphisms of ERCC4 rs6498486 and ERCC5 rs751402 were detected by PCR-RFLP. Multiple factors logistic regression analysis was conducted to investigate the association between gene polymorphisms and risk of salivary gland tumors using SPSS 18.0 software package.
  
  
  RESULTS
  The genotype distribution of each polymorphism was found to be of Hardy-Weinberg equilibrium in the study. ERCC5 rs751402 TT genotype was associated with risk of salivary gland tumors (TT vs. CC+CT: OR=0.45, 95% CI: 0.21-0.98, P=0.046). No significant association was found in ERCC4 rs6498486.
  
  
  CONCLUSIONS
  The results suggest that ERCC5 rs751402 polymorphism may be associated with risk of salivary gland tumors.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Shengjing Hospital, China Medical University. Shenyang 110004, Liaoning Province, China.E-mail:cmumengxue@126.com.
authors.forename: Xue
authors.initials: X
authors.lastname: Meng
authors.forename: Qiu-xu
authors.initials: QX
authors.lastname: Wang
authors.forename: Mo-ye
authors.initials: MY
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Qin
authors.forename: Yu-peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Liu
mesh_terms: D016022:Case-Control Studies; D004260:DNA Repair; D004268:DNA-Binding Proteins; D004720:Endonucleases; D005838:Genotype; D006801:Humans; D009687:Nuclear Proteins; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012468:Salivary Gland Neoplasms; D012469:Salivary Glands; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5; C095888:xeroderma pigmentosum group F protein