title: No association between cytochrome P450 2D6 gene polymorphism and risk of acute leukemia: evidence based on a meta-analysis.
abstract: BACKGROUND
  Many studies indicated the human cytochrome P450 2D6 (CYP2D6) gene polymorphism was associated with acute leukemia (AL) susceptibility, however, the results were inconsistent. So we performed this meta-analysis to evaluate the relationship between CYP2D6*3 or CYP2D6*4 polymorphism and AL susceptibility.
  
  
  METHODS
  We searched PubMed database up to February 20, 2013, and finally yielded 9 case-control studies including 1343 cases and 1843 controls which tested the association between CYP2D6*3 or *4 polymorphism and AL. After data extraction, we conducted a meta-analysis using the Comprehensive Meta Analysis software.
  
  
  RESULTS
  Overall, no significant association between CYP2D6*3 or *4 polymorphism and AL risk was found in this metaanalysis (+ vs. -: OR = 1.13, 95% CI = 0.79-1.63; +/+ vs. -/-: OR = 1.73, 95% CI = 0.99-3.02; -/+ vs. -/-: OR = 1.03, 95% CI = 0.68-1.56; (-/+ and +/+) vs. -/-: OR = 1.08, 95% CI = 0.72-1.63; +/+ vs. (-/+ and -/-): OR = 1.76, 95% CI = 0.98-3.17). Similar results were also been found in stratified subgroup analysis. There was no publication bias.
  
  
  CONCLUSIONS
  CYP2D6*3 or *4 polymorphism might not be associated with AL susceptibility. However, the results need to be further confirmed by well-designed and high quality randomized controlled trials with larger sample sizes.
authors.affiliation: Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei 430022, China.
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Ruan
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Xian-tao
authors.initials: XT
authors.lastname: Zeng
authors.forename: Ling-hui
authors.initials: LH
authors.lastname: Xia
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000208:Acute Disease; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D019389:Cytochrome P-450 CYP2D6