title: High-sensitivity cardiac troponin T predicts nondipper hypertension in newly diagnosed hypertensive patients.
abstract: The increased prognostic accuracy of the high-sensitivity cardiac troponin T (hs-cTnT) assay vs the conventional cTnT assay has recently been reported in hypertensive patients. The authors aimed to investigate the significance of serum hs-cTnT marker for prediction of nondipper hypertension (HTN) in hypertensive patients. A total of 317 patients with newly diagnosed HTN were studied. The patients were divided into two groups: 198 dipper hypertensive patients (mean age, 51.7 ± 5.1 years) and 119 nondipper hypertensive patients (mean age, 53.4 ± 7.6 years). Hs-cTnT and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured in all patients. hs-cTnT and NT-proBNP were independent predictors for nondipper HTN (P<.05 for all). The cutoff value of hs-cTnT obtained by the receiver operator curve analysis was 7.55 ng/L for the prediction of nondipper HTN (sensitivity: 79%, specificity: 70%; 95% confidence interval, 0.769-0.860; P<.001). In patients with HTN, higher serum concentration of hs-cTnT even within normal range is an independent predictor of nondipper HTN.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypaklı
authors.forename: Durmuş Y
authors.initials: DY
authors.lastname: Şahin
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Nermin Y
authors.initials: NY
authors.lastname: Koyunsever
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Sen
mesh_terms: D015415:Biomarkers / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain