title: Copper catalyzed synthesis of fused benzimidazolopyrazine derivatives via tandem benzimidazole formation/annulation of δ-alkynyl aldehyde.
abstract: A novel route to synthesize the biologically active benzimidazolopyrazine core is outlined. The reaction proceeds via tandem benzimidazole formation/annulations of indole, pyrrole and aliphatic δ-alkynyl aldehydes in the presence of copper salts and green solvents with moderate to good yields.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad 500046, India. rnsc@uohyd.ernet.in.
authors.forename: Subburethinam
authors.initials: S
authors.lastname: Ramesh
authors.forename: Suman
authors.initials: S
authors.lastname: Kr Ghosh
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Nagarajan
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011719:Pyrazines / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000447:Aldehydes; D001562:Benzimidazoles; D011719:Pyrazines; D003300:Copper; C031000:benzimidazole