title: Antisynthetase syndrome: not just an inflammatory myopathy.
abstract: In recent years, antisynthetase syndrome has been recognized as an important cause of autoimmune inflammatory myopathy in a subset of patients with polymyositis and dermatomyositis. It is associated with serum antibodies to aminoacyl-transfer RNA synthetases and is characterized by a constellation of manifestations, including fever, myositis, interstitial lung disease, "mechanic's hands," Raynaud phenomenon, and polyarthritis. Physicians should be familiar with its variety of clinical presentations and should include it in the differential diagnosis in patients presenting with unexplained interstitial lung disease.
authors.affiliation: Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Staff, Department of Rheumatic and Immunologic Diseases, Orthopedics and Rheumatology, Institute, Cleveland Clinic.
authors.forename: Soumya
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Richard
authors.initials: R
authors.lastname: Prayson
authors.forename: Carol
authors.initials: C
authors.lastname: Farver
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001168:Arthritis / Q000209:etiology; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009220:Myositis / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D011928:Raynaud Disease / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; C046750:Jo-1 antibody