title: Nonstandard peptide expression under the genetic code consisting of reprogrammed dual sense codons.
abstract: We here demonstrate a translation system that is governed by a reprogrammed genetic code consisting of "dual sense codons." A dual sense codon assigns two distinct amino acids for initiation and elongation. Because multiple dual sense codons independently function without cross-readings, this system enables the expansion of the repertoire of initiators as well as elongators that can be used simultaneously.
authors.affiliation: Department of Chemistry, Graduate School of Science, §Department of Chemistry and Biotechnology, Graduate School of Engineering, and ∥Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo , Tokyo 113-0033, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Goto
authors.forename: Megumi
authors.initials: M
authors.lastname: Iseki
authors.forename: Azusa
authors.initials: A
authors.lastname: Hitomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murakami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suga
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002474:Cell-Free System / Q000737:chemistry / Q000378:metabolism; D003062:Codon; D018387:Codon, Initiator; D005815:Genetic Code; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012346:RNA, Transfer, Amino Acyl / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000596:Amino Acids; D003062:Codon; D018387:Codon, Initiator; D010455:Peptides; D012346:RNA, Transfer, Amino Acyl