title: TSC on the peroxisome controls mTORC1.
abstract: mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.
authors.affiliation: Biozentrum, University of Basel, CH4056 Basel, Switzerland.
authors.forename: Don
authors.initials: D
authors.lastname: Benjamin
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D000818:Animals; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008954:Models, Biological; D020675:Peroxisomes / Q000378:metabolism*; D011485:Protein Binding; D058570:TOR Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism*; D014402:Tuberous Sclerosis / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases