title: A histone timer for zygotic genome activation.
abstract: Histone H1 variants play key roles in the regulation of higher-order chromatin structure and have been implicated in numerous developmental processes. In this issue of Developmental Cell, Pérez-Montero et al. (2013) present evidence that the Drosophila histone H1 variant dBigH1 prevents premature activation of the zygotic genome during early embryogenesis.
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Siriaco
authors.forename: John W
authors.initials: JW
authors.lastname: Tamkun
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D049750:Genome, Insect; D006657:Histones / Q000378:metabolism*; D015053:Zygote / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D006657:Histones