title: "One pot" regiospecific synthesis of polysubstituted pyrroles from benzylamines and ynones under metal free conditions.
abstract: A convenient "one-pot" weak base-promoted synthesis of polysubstituted pyrroles has been developed from benzylamines and ynones. This transformation involves the Michael addition reaction and intramolecular condensation, which features high regioselectivity, high efficiency, environmental friendliness and metal free. A series of polysubstituted pyrroles were provided in up to 91% yield for 27 examples.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Shen
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D000475:Alkenes / Q000737:chemistry; D001596:Benzylamines / Q000737:chemistry*; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001596:Benzylamines; D007659:Ketones; D008670:Metals; D011758:Pyrroles