title: Three new polyketides from marine-derived fungus Penicillium citrinum SCSGAF 0167.
abstract: Three new polyketides penicitrinol G (1), penicitrinol H (2) and 2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone (3) together with one known cathepsin B inhibitor chrysophanol (4) were isolated from a culture broth of marine-derived fungus Penicillium citrinum SCSGAF 0167. Their structures were determined by spectroscopic methods. Compound 4 exhibited inhibitory activity against cathepsin B with IC50 value of 1.7 μM.
authors.affiliation: a Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, The Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301 , Guangdong , P.R. China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Sun
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zheng
authors.forename: Xin-Ya
authors.initials: XY
authors.lastname: Xu
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Qi
mesh_terms: D000880:Anthraquinones / Q000494:pharmacology; D002401:Cathepsin B / Q000037:antagonists & inhibitors*; D002953:Citrinin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010407:Penicillium / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000591263:2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone; D000880:Anthraquinones; D061065:Polyketides; D044004:Xanthones; C000591261:penicitrinol G; C000591262:penicitrinol H; D002953:Citrinin; D002401:Cathepsin B; C027113:chrysophanic acid