title: [Dupuytren's disease - patient satisfaction and functional results one year after partial fasciectomy and injection of collagenase].
abstract: BACKGROUND
  The gold standard in the treatment of Dupuytren's disease is the partial fasciectomy (PF). Injection of a collagenase directly into the Dupuytren cord is an alternative method. In contrast to needle fasciotomy, destruction of the cord is achieved enzymatically and not mechanically. 24 h after injection, the treated finger can be extended passively to disrupt the Dupuytren cord.
  
  
  METHODS
  Functional outcome and patient satisfaction were prospectively analysed in 2 comparable groups of patients with the same stage of disease. Follow-up was one year. Patients in the first group underwent partial fasciectomy (PF) (n=13), whereas patients in the second group were treated by an injection of collagenase (CG) in the diseased tissue (n=14). Besides clinical examination, outcome was evaluated by validated questionnaires (DASH/MHQ) and a customised questionnaire.
  
  
  RESULTS
  Extension after PF (mean residual contracture 7.5°) was better than after collagenase injection (mean residual contracture 13.2°). Side-effects like numbness, impaired blood circulation and pain were less after injection of collagenase than after PF and of shorter duration. Recovery of grip strength was faster in the CG than after PF and collagenase injection was regarded as less discomforting. The results of the questionnaires showed a reduction of hand function 1 month after surgery, whereas better results were observed 1 month after collagenase injection. Recovery in the CG was significantly faster than after PF.
  
  
  CONCLUSIONS
  Collagenase injection, as a less invasive technique, has less and milder side-effects than surgery and demonstrated a better total reduction of Dupuytren's contracture initially, although the residual contractures were higher in the CG after follow-up of 1 year. Patient satisfaction was higher after collagenase injection due to subjectively perceived less negative impact and a comparable functional outcome.
authors.affiliation: Klinikum Bielefeld, Klinik für Plastische, Wiederherstellungs- und Ästhetische Chirurgie, Handchirurgie, Bielefeld.
authors.forename: F H
authors.initials: FH
authors.lastname: Vollbach
authors.forename: L
authors.initials: L
authors.lastname: Walle
authors.forename: H
authors.initials: H
authors.lastname: Fansa
mesh_terms: D000328:Adult; D017364:Collagenases / Q000008:administration & dosage*; D004185:Disability Evaluation; D004387:Dupuytren Contracture / Q000503:physiopathology / Q000628:therapy*; D005205:Fascia / Q000503:physiopathology; D000071938:Fasciotomy; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D017060:Patient Satisfaction; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000502:physiology; D012008:Recurrence; D011795:Surveys and Questionnaires
chemical_list: D017364:Collagenases