title: A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach.
abstract: With the extensive progress in nanotechnology-based drug delivery systems, pharmacokinetic evaluations have gained much attention from researchers as a central part of the study of these systems. Because the fulfillment of any therapeutic goal(s) by a novel drug delivery system requires that the absorption, distribution, metabolism, and excretion (ADME) be considered from the early stages of the system design to the final clinical evaluations, extensive knowledge of the pharmacokinetic aspects related to ADME is a crucial part of research in this field. The main objectives of the nanotechnology-based drug delivery systems from a pharmacokinetic viewpoint are (1) an improved drug-release profile in vivo, (2) enhanced drug absorption, (3) site-directed drug distribution, (4) a modified drug metabolism pattern, (5) prolonged drug residence time in body (e.g., in blood circulation), and (6) delayed and/or decreased renal excretion of the drug. Accordingly, the purpose of the current review is to present an insightful summary of pharmacokinetic analyses of nanotechnology-based drug delivery systems along with a critical review of recent findings.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Science.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hamidi
authors.forename: Amir
authors.initials: A
authors.lastname: Azadi
authors.forename: Pedram
authors.initials: P
authors.lastname: Rafiei
authors.forename: Hajar
authors.initials: H
authors.lastname: Ashrafi
mesh_terms: D000042:Absorption; D000818:Animals; D001711:Biotransformation; D004337:Drug Carriers / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000639:trends; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D036103:Nanotechnology / Q000639:trends; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations