title: Automated analgesic drugs delivery guided by vagal tone evaluation: interest of the Analgesia Nociception Index (ANI).
abstract: Analgesic drugs delivery optimization constitutes one of the main objectives of modern anesthesia. Indeed, their over or under determination constitutes a risk for anesthetized patient in terms of hemodynamic reactivity or post-operative hyperalgesia. Nowadays, new physiological indexes allow anesthesiologists to evaluate the balance between the analgesia level and the noxious stimulus importance. ANI is an index related to the autonomic nervous system activity based on heart rate variability analysis. Its ability for the analgesia / nociception balance evaluation has been established bringing evidences about its helpfulness for analgesic drug delivery. In this article, we describe a device for automatic analgesic drugs administration based on the ANI evolution during surgical procedures under general anesthesia. We hypothesized that such a device could improve the quality and safety of anesthesia by reducing adverse cardiovascular events and delivered analgesic drugs doses.
authors.forename: J
authors.initials: J
authors.lastname: De jonckheere
authors.forename: M
authors.initials: M
authors.lastname: Delecroix
authors.forename: M
authors.initials: M
authors.lastname: Jeanne
authors.forename: A
authors.initials: A
authors.lastname: Keribedj
authors.forename: N
authors.initials: N
authors.lastname: Couturier
authors.forename: R
authors.initials: R
authors.lastname: Logier
mesh_terms: D000465:Algorithms; D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000008:administration & dosage*; D000758:Anesthesia; D000768:Anesthesia, General / Q000379:methods; D019540:Area Under Curve; D001341:Autonomic Nervous System / Q000502:physiology*; D003198:Computer Simulation; D016503:Drug Delivery Systems; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D010146:Pain; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement / Q000379:methods*; D012984:Software; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects*
chemical_list: D000700:Analgesics