title: Area stenosis associated with non-invasive fractional flow reserve obtained from coronary CT images.
abstract: Fractional flow reserve (FFR) determined by invasive angiography is the gold standard to assess the severity of coronary artery disease (CAD). FFRCT can be obtained non-invasively by combining computed tomography (CT) images and Computational Fluid Dynamics (CFD) method. In this study, FFRCT was computed for 6 models of patient-specific left coronary artery trees reconstructed from CT images. A total of 12 stenoses were observed. FFR values obtained for 7 of the 12 stenoses during invasive angiography were used as the gold standard for comparison. On a per-stenosis basis, the sensitivity, specificity, positive predictive value and negative predictive value were 50%, 100%, 100% and 83.3% respectively for FFRCT. A weak correlation was found between percent lumen diameter stenosis and FFRCT (r=0.431; p>0.05). However, the correlation between percent lumen area stenosis and FFRCT was significant (r=0.853; p<0.05). Therefore, non-invasive FFRCT appears to be a promising index to assess the severity of CAD and lumen area has distinct advantages over diameter measurement in terms of anatomy assessment.
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Tong
authors.initials: T
authors.lastname: Luo
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Huo
authors.forename: Min
authors.initials: M
authors.lastname: Wan
authors.forename: Terrance
authors.initials: T
authors.lastname: Chua
authors.forename: Ru San
authors.initials: RS
authors.lastname: Tan
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Kassab
authors.forename: Swee Yaw
authors.initials: SY
authors.lastname: Tan
authors.forename: Liang
authors.initials: L
authors.lastname: Zhong
mesh_terms: D002637:Chest Pain / Q000175:diagnosis*; D003287:Contrast Media; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D053805:Fractional Flow Reserve, Myocardial; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D008955:Models, Cardiovascular; D011446:Prospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media