title: Cervical precancerous lesions and cancer among patients in the gynaecology outpatient department at a tertiary hospital in South Africa.
abstract: BACKGROUND
  The purpose of this study was to determine proportional rates of cervical precancerous lesions and cancer, and associations with socio-demographic variables, HIV status, and CD4 cell count.
  
  
  METHODS
  A retrospective comparative study was conducted targeting the medical records of all women over age 18 that were diagnosed histologically through colposcopy with cervical precancerous lesions and cancer from 1 December 2011 to 30 November 2012.
  
  
  RESULTS
  A total of 313 patient records were used for data analysis. The average age was 39.1 (SD=2.04) years. More than a third (37.1%) of the patients had CIN III or cervical cancer. There was a significant association between age, CD4 cell count, HIV status, and cervical lesions (p<0.05). Age was found to be an influential predictor of cervical lesions (OR=0.67, 95%CI: 0.46-0.98).
  
  
  CONCLUSIONS
  There exists an association between age and cervical lesions, with presentation of cervical precancerous lesions and cervical cancer at a younger age among HIV reactive patients. The National Guidelines should be brought in line with the National HIV Counseling and Testing Policy to offer Pap smears to all sexually active women that test HIV reactive during routine HIV Testing.
authors.affiliation: Clinical Manager, Rahima Moosa Hospital, Johannesburg, South Africa E-mail : muhammad.ehsanul@gmail.com, hoque@ukzn.ac.za.
authors.forename: Edward
authors.initials: E
authors.lastname: Hank
authors.forename: Muhammad Ehsanul
authors.initials: ME
authors.lastname: Hoque
authors.forename: Lindiwe
authors.initials: L
authors.lastname: Zungu
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D003127:Colposcopy; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D010045:Outpatients / Q000706:statistics & numerical data*; D065006:Papanicolaou Test; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D062606:Tertiary Care Centers; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology