title: Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development.
abstract: To assess the possible contribution of host immune responses to the exertion of Fv2-associated resistance to Friend virus (FV)-induced disease development, we inoculated C57BL/6 (B6) mice that lacked various subsets of lymphocytes with FV containing no lactate dehydrogenase-elevating virus. Fv2(r) B6 mice lacking CD4(+) T cells developed early polycythemia and fatal erythroleukemia, while B6 mice lacking CD8(+) T cells remained resistant. Erythroid progenitor cells infected with spleen focus-forming virus (SFFV) were eliminated, and no polycythemia was observed in B cell-deficient B6 mice, but they later developed myeloid leukemia associated with oligoclonal integration of ecotropic Friend murine leukemia virus. Additional depletion of natural killer and/or CD8(+) T cells from B cell-deficient B6 mice resulted in the expansion of SFFV proviruses and the development of polycythemia, indicating that SFFV-infected erythroid cells are not only restricted in their growth but are actively eliminated in Fv2(r) mice through cellular immune responses.
authors.affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Tsuji-Kawahara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawabata
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsukuma
authors.forename: Saori
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Tomomi
authors.initials: T
authors.lastname: Chikaishi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyazawa
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D060467:Disease Resistance; D005260:Female; D005622:Friend murine leukemia virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D008297:Male; D051379:Mice; D057507:Mice, 129 Strain; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012376:Rodent Diseases / Q000276:immunology* / Q000821:virology; D013155:Spleen Focus-Forming Viruses / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology