title: The prevalence of obesity is increased in patients with late compared with early onset psoriasis.
abstract: OBJECTIVE
  We compared the clinical and epidemiologic characteristics of early and late onset psoriasis with an emphasis on potential differences in the comorbidities associated with each subtype.
  
  
  METHODS
  An observational, multicenter study was performed, and associations between the age at the time of diagnosis and binary comorbidity outcomes were evaluated using multiple logistic regression analysis adjusted for age and other relevant confounders.
  
  
  RESULTS
  An increased prevalence of positive family history, psoriatic arthritis, and depression was observed in patients with early onset psoriasis. On the other hand, late onset psoriasis was more frequently associated with obesity and elevated waist circumference compared with early onset form. Elderly psoriatic patients (at the age of 75 years) with late onset psoriasis are at an especially high risk for obesity compared with individuals at the same age with an early onset disease.
  
  
  CONCLUSIONS
  The increased frequency of psoriasis in the family of early onset patients may suggest that manifestation of psoriasis at younger age is driven by strong genetic influence. However, such a remarkable association of abdominal obesity with late onset psoriasis may suggest that obesity can be one of the acquired factors that may predispose for the development of psoriasis in the elderly.
authors.affiliation: Department of Dermatology, Medical and Health Science Centre, University of Debrecen, Hungary.
authors.forename: Emese
authors.initials: E
authors.lastname: Herédi
authors.forename: Anikó
authors.initials: A
authors.lastname: Csordás
authors.forename: Marcell
authors.initials: M
authors.lastname: Clemens
authors.forename: Balázs
authors.initials: B
authors.lastname: Adám
authors.forename: Krisztián
authors.initials: K
authors.lastname: Gáspár
authors.forename: Dániel
authors.initials: D
authors.lastname: Törőcsik
authors.forename: Georgina
authors.initials: G
authors.lastname: Nagy
authors.forename: Róza
authors.initials: R
authors.lastname: Adány
authors.forename: János
authors.initials: J
authors.lastname: Gaál
authors.forename: Eva
authors.initials: E
authors.lastname: Remenyik
authors.forename: Andrea
authors.initials: A
authors.lastname: Szegedi
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors; D055105:Waist Circumference
keywords: Age of onset; Comorbidity; Psoriasis