title: Estimation of aortic pressure waveforms from 4D phase-contrast MRI.
abstract: Several approaches for the non-invasive MRI-based measurement of the aortic pressure waveform over the heart cycle have been proposed in the last years. These methods are normally based on time-resolved, two-dimensional phase-contrast sequences with uni-directionally encoded velocities (2D PC-MRI). In contrast, three-dimensional acquisitions with tridirectional velocity encoding (4D PC-MRI) have been shown to be a suitable data source for detailed investigations of blood flow and spatial blood pressure maps. In order to avoid additional MR acquisitions, it would be advantageous if the aortic pressure waveform could also be computed from this particular form of MRI. Therefore, we propose an approach for the computation of the aortic pressure waveform which can be completely performed using 4D PC-MRI. After the application of a segmentation algorithm, the approach automatically computes the aortic pressure waveform without any manual steps. We show that our method agrees well with catheter measurements in an experimental phantom setup and produces physiologically realistic results in three healthy volunteers.
authors.forename: Michael
authors.initials: M
authors.lastname: Delles
authors.forename: Fabian
authors.initials: F
authors.lastname: Rengier
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Hendrik
authors.initials: H
authors.lastname: von Tengg-Kobligk
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Dillmann
authors.forename: Roland
authors.initials: R
authors.lastname: Unterhinninghofen
mesh_terms: D000465:Algorithms; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure; D057785:Catheters; D003287:Contrast Media; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D063177:Pulse Wave Analysis; D058067:Wavelet Analysis; D055815:Young Adult
chemical_list: D003287:Contrast Media