title: Hippocampal and mesial temporal sclerosis in early-onset frontotemporal lobar degeneration versus Alzheimer's disease.
abstract: Hippocampal sclerosis (HS) and mesial temporal sclerosis (MTS) may occur with frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) as well as with normal aging. Prior studies suggest that HS/MTS may be more closely associated with FTLD but have not directly compared the prevalence and clinical characteristics of HS/MTS between neuropathologically confirmed early-onset (age ≤ 65) cohorts of FTLD and AD. We identified patients with early-onset FTLD (n = 136) and AD (n = 267) from National Alzheimer's Center Consortium databases and compared neuropathological and clinical data between these 2 groups. The FTLD group had a significantly higher prevalence of HS/MTS than that of the AD group. However, HS/MTS was associated with increasing age and memory impairment in the AD group but not in the FTLD group. These findings are consistent with the hypothesis that HS/MTS in FTLD occurs as part of the primary pathological process, rather than as a secondary, nonspecific effect of aging on memory and hippocampal function.
authors.affiliation: 1Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
authors.forename: Simantini J.
authors.initials: SJ
authors.lastname: Karve
authors.forename: Edmond
authors.initials: E
authors.lastname: Teng
authors.forename: Kanida
authors.initials: K
authors.lastname: Tassniyom
authors.forename: Mario F
authors.initials: MF
authors.lastname: Mendez
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D018888:Aphasia, Primary Progressive / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D057180:Frontotemporal Dementia / Q000473:pathology; D057174:Frontotemporal Lobar Degeneration / Q000473:pathology*; D005911:Gliosis / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D012598:Sclerosis; D013494:Supranuclear Palsy, Progressive / Q000473:pathology
keywords: Alzheimer’s disease; behavioral variant frontotemporal dementia; frontotemporal lobar degeneration; hippocampal sclerosis