title: Functional interaction between autophagy and ciliogenesis.
abstract: Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.
authors.affiliation: Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Olatz
authors.initials: O
authors.lastname: Pampliega
authors.forename: Idil
authors.initials: I
authors.lastname: Orhon
authors.forename: Bindi
authors.initials: B
authors.lastname: Patel
authors.forename: Sunandini
authors.initials: S
authors.lastname: Sridhar
authors.forename: Antonio
authors.initials: A
authors.lastname: Díaz-Carretero
authors.forename: Isabelle
authors.initials: I
authors.lastname: Beau
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
authors.forename: Birgit H
authors.initials: BH
authors.lastname: Satir
authors.forename: Peter
authors.initials: P
authors.lastname: Satir
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Cuervo
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D002923:Cilia / Q000378:metabolism / Q000502:physiology*; D053823:Hedgehog Proteins / Q000378:metabolism; D051379:Mice; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D053823:Hedgehog Proteins; C514104:Ift20 protein, mouse