title: Seropositivity to Helicobacter pylori and risk of pancreatic cancer.
abstract: Helicobacter pylori (H. pylori) seropositivity has been inconsistently associated with pancreatic cancer. We, therefore, investigated the association between H. pylori seropositivity and pancreatic cancer in a case-control study nested within Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of Finnish male smokers. Pancreatic cancer cases (n = 353) and control subjects (n = 353) were matched on date of baseline serum collection, age at randomization, and follow-up time (up to 23.9 years). We used a multiplex serology assay to determine the sero-status of antibodies against 15 H. pylori-specific antigens in fasting serum samples. Conditional logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (CI). Neither targeted H. pylori antigens in serum nor the combination of all was associated with development of pancreatic cancer (combination of all: OR, 0.85; 95% CI, 0.49-1.49). Our results suggest that H. pylori is not a risk factor for pancreatic cancer.
authors.affiliation: Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; Division of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center, Heidelberg, Germany; and Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Guoqin
authors.initials: G
authors.lastname: Yu
authors.forename: Gwen
authors.initials: G
authors.lastname: Murphy
authors.forename: Angelika
authors.initials: A
authors.lastname: Michel
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Weinstein
authors.forename: Satu
authors.initials: S
authors.lastname: Männistö
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Michael
authors.initials: M
authors.lastname: Pawlita
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005387:Finland / Q000453:epidemiology; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000382:microbiology*