title: To be or not to be assembled: progressing into nuclear actin filaments.
abstract: The paradigm states that cytoplasmic actin operates as filaments and nuclear actin is mainly monomeric, acting as a scaffold in transcription complexes. However, why should a powerful function of actin, namely polymerization, not be used in the nucleus? Recent progress in the field forces us to rethink this issue, as many actin filament assembly proteins have been linked to nuclear functions and new experimental approaches have provided the first direct visualizations of polymerized nuclear actin.
authors.affiliation: Biochemical-Pharmacological Center (BPC), Institute of Pharmacology, University of Marburg, 35043 Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Grosse
authors.forename: Maria K
authors.initials: MK
authors.lastname: Vartiainen
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D058105:Polymerization