title: Detectability and appraisal thresholds of split pulse signals for the MemoPatch™ device, an electronic skin patch intended to deliver tactile medication reminder signals (study TS-104).
abstract: Patient non-adherence to prescribed medication regimens is a significant problem and affects clinical treatment outcomes. The MemoPatch™ medical device, currently in development, is an electronic skin patch intended to deliver tactile medication reminder signals. Fifty volunteers completed a laboratory experiment that evaluated the detectability and appraisal thresholds of five split signals; specifically, the current thresholds (in mA) at which a signal was detected (threshold T1), was considered sufficiently detectable to serve as a reminder signal (threshold T2), and became too strong as a reminder signal (threshold T3). Signals were selected under consideration of three data points: T1Max and T2Max (defined as, resp., the maximum current observed at T1 and T2) and T3Pct90 (the T3 current at the 90(th) percentile). A signal was considered to be useable in future versions of the MemoPatch™ device if it met the constraint that (T3Pct90-T2Max) should not be negative. One signal met the constraint requirement as its T3Pct90-T2Max=0.96mA.
authors.forename: Ivo
authors.initials: I
authors.lastname: Abraham
authors.forename: Wim
authors.initials: W
authors.lastname: De Geest
authors.forename: Jan
authors.initials: J
authors.lastname: De Geest
authors.forename: Elke
authors.initials: E
authors.lastname: De Troy
authors.forename: Karen
authors.initials: K
authors.lastname: MacDonald
mesh_terms: D000328:Adult; D004560:Electricity; D004582:Electronics, Medical / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D017010:Reminder Systems / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted; D012867:Skin; D014110:Touch