title: Nonsteroidal anti-inflammatory drug-induced hepatoxicity.
abstract: Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.
authors.affiliation: Division of Hospital Internal Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Unzueta
authors.forename: Hugo E
authors.initials: HE
authors.lastname: Vargas
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans; D011358:Product Surveillance, Postmarketing
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Acute liver injury; Drug safety; Drug surveillance; Drug-induced liver injury; Hy’s law; Idiosyncratic hepatotoxicity; Liver transplantation; Nonsteroidal anti-inflammatory drugs