title: Predictors of disease severity in patients admitted to a cholera treatment center in urban Haiti.
abstract: Cholera, previously unrecognized in Haiti, spread through the country in the fall of 2010. An analysis was performed to understand the epidemiological characteristics, clinical management, and risk factors for disease severity in a population seen at the GHESKIO Cholera Treatment Center in Port-au-Prince. A comprehensive review of the medical records of patients admitted during the period of October 28, 2010-July 10, 2011 was conducted. Disease severity on admission was directly correlated with older age, more prolonged length of stay, and presentation during the two epidemic waves seen in the observation period. Although there was a high seroprevalence of human immunodeficiency virus (HIV), severity of cholera was not greater with HIV infection. This study documents the correlation of cholera waves with rainfall and its reduction in settings with improved sanitary conditions and potable water when newly introduced cholera affects all ages equally so that interventions must be directed throughout the population.
authors.forename: Claude-Lyne
authors.initials: CL
authors.lastname: Valcin
authors.forename: Karine
authors.initials: K
authors.lastname: Severe
authors.forename: Claudia T
authors.initials: CT
authors.lastname: Riche
authors.forename: Benedict S
authors.initials: BS
authors.lastname: Anglade
authors.forename: Colette Guiteau
authors.initials: CG
authors.lastname: Moise
authors.forename: Michael
authors.initials: M
authors.lastname: Woodworth
authors.forename: Macarthur
authors.initials: M
authors.lastname: Charles
authors.forename: Zhongze
authors.initials: Z
authors.lastname: Li
authors.forename: Patrice
authors.initials: P
authors.lastname: Joseph
authors.forename: Jean W
authors.initials: JW
authors.lastname: Pape
authors.forename: Peter F
authors.initials: PF
authors.lastname: Wright
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology* / Q000473:pathology*; D002947:Cities; D003681:Dehydration; D058872:Epidemics / Q000517:prevention & control* / Q000706:statistics & numerical data*; D005260:Female; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011891:Rain; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult