title: Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach.
abstract: Definitions of shock and resuscitation endpoints traditionally focus on blood pressures and cardiac output. This carries a high risk of overemphasizing systemic hemodynamics at the cost of tissue perfusion. In line with novel shock definitions and evidence of the lack of a correlation between macro- and microcirculation in shock, we recommend that macrocirculatory resuscitation endpoints, particularly arterial and central venous pressure as well as cardiac output, be reconsidered. In this viewpoint article, we propose a three-step approach of resuscitation endpoints in shock of all origins. This approach targets only a minimum individual and context-sensitive mean arterial blood pressure (for example, 45 to 50 mm Hg) to preserve heart and brain perfusion. Further resuscitation is exclusively guided by endpoints of tissue perfusion irrespectively of the presence of arterial hypotension ('permissive hypotension'). Finally, optimization of individual tissue (for example, renal) perfusion is targeted. Prospective clinical studies are necessary to confirm the postulated benefits of targeting these resuscitation endpoints.
authors.forename: Martin W
authors.initials: MW
authors.lastname: Dünser
authors.forename: Jukka
authors.initials: J
authors.lastname: Takala
authors.forename: Andreas
authors.initials: A
authors.lastname: Brunauer
authors.forename: Jan
authors.initials: J
authors.lastname: Bakker
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000378:metabolism; D015687:Cell Hypoxia / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007022:Hypotension / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D012151:Resuscitation / Q000379:methods*; D012769:Shock / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D015415:Biomarkers; D010100:Oxygen