title: A model-based approach for the evaluation of vagal and sympathetic activities in a newborn lamb.
abstract: This paper proposes a baroreflex model and a recursive identification method to estimate the time-varying vagal and sympathetic contributions to heart rate variability during autonomic maneuvers. The baroreflex model includes baroreceptors, cardiovascular control center, parasympathetic and sympathetic pathways. The gains of the global afferent sympathetic and vagal pathways are identified recursively. The method has been validated on data from newborn lambs, which have been acquired during the application of an autonomic maneuver, without medication and under beta-blockers. Results show a close match between experimental and simulated signals under both conditions. The vagal and sympathetic contributions have been simulated and, as expected, it is possible to observe different baroreflex responses under beta-blockers compared to baseline conditions.
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: David
authors.initials: D
authors.lastname: Ojeda
authors.forename: Alain
authors.initials: A
authors.lastname: Beuchée
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Praud
authors.forename: Patrick
authors.initials: P
authors.lastname: Pladys
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry; D000818:Animals; D000831:Animals, Newborn; D001341:Autonomic Nervous System / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology*; D002319:Cardiovascular System; D003198:Computer Simulation; D006339:Heart Rate / Q000502:physiology*; D008526:Medulla Oblongata / Q000502:physiology; D009599:Nitroprusside / Q000737:chemistry; D010656:Phenylephrine / Q000737:chemistry; D011311:Pressoreceptors / Q000502:physiology*; D012756:Sheep; D034561:Sheep, Domestic; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D000319:Adrenergic beta-Antagonists; D009599:Nitroprusside; D010656:Phenylephrine