title: Rapid screening of potential metallic glasses for biomedical applications.
abstract: This paper presents a rapid screening process to select potential titanium and zirconium based metallic glasses (MGs) for bio-material applications. Electrochemical activity of 7 MGs including 6 bulk metallic glasses and 1 thin-film deposited MG in simulation body and human serum is first inspected. A low-voltage potential state test is also developed to simulate the cell membrane potential that the implant MGs will suffer. Results show that the MGs composed of Ti65Si15Ta10Zr10 and Ta57Zr23Cu12Ti8 exhibit excellent electrochemical stability in both simulation body fluid and human serum. In addition, the copper content in the MGs plays an important role on the electrochemical activity. MGs with the copper content higher than 17.5% show significant electrochemical responses. The cytotoxicity of the solid MG samples and the corrosion released ions are also evaluated by an in-vitro MTT test utilizing the murine bone marrow stem cells. Results indicate that all the solid MG samples show no acute cytotoxicity yet the corrosion released ions show significant toxicity for murine bone marrow stem cells. The rapid screening process developed in the present study suggests that the Ti65Si15Ta10Zr10 metallic glass has high potential for biomedical applications due to its good electrochemical stability and very low cytotoxicity.
authors.affiliation: Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC.
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: C H
authors.initials: CH
authors.lastname: Huang
authors.forename: J F
authors.initials: JF
authors.lastname: Chuang
authors.forename: J C
authors.initials: JC
authors.lastname: Huang
authors.forename: J S C
authors.initials: JS
authors.lastname: Jang
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D055664:Electrochemical Techniques; D005898:Glass / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D051379:Mice; D013234:Stem Cells / Q000166:cytology
chemical_list: D000497:Alloys; D007477:Ions; D008670:Metals
keywords: Cytotoxicity; Electrochemical activity; MTT test; Metallic glasses; Potential state