title: Protein-losing nephropathy associated with Borrelia burgdorferi seropositivity in a soft-coated wheaten terrier: response to therapy.
abstract: A soft-coated wheaten terrier was examined for lameness with subsequent identification of protein-losing nephropathy, hypoalbuminemia, hyperglobulinemia, and seroconversion to Borrelia burgdorferi. Following doxycycline therapy, the urine protein loss decreased significantly and serum albumin concentration remained close to or within the reference interval for over 3 years, contrary to the reported poor prognosis for renal disease associated with B. burgdorferi or protein-losing nephropathy of soft-coated wheaten terriers.
authors.affiliation: Department of Pathology and Microbiology (Horney) and Department of Companion Animals (Stojanovic), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Horney
authors.forename: Vladimir
authors.initials: V
authors.lastname: Stojanovic
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D025065:Borrelia burgdorferi; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D034141:Hypoalbuminemia / Q000209:etiology / Q000662:veterinary; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008193:Lyme Disease / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D012698:Serologic Tests
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline