title: Evaluation of antioxidant, immunomodulatory, and cytotoxic action of fractions from Eugenia uniflora L. and Eugenia malaccensis L.: correlation with polyphenol and flavanoid content.
abstract: An increasing number of biological activities presented by medicinal plants has been investigated over the years, and they are used in the search for new substances with lower side effects. Eugenia uniflora L. and Eugenia malaccensis L. (Myrtaceae) have many folk uses in various countries. This current study was designed to quantify the polyphenols and flavonoids contents and evaluate the immunomodulatory, antioxidant, and cytotoxic potentials of fractions from E. uniflora L. and E. malaccensis L. It was observed that the polyphenol content was higher in ethyl acetate fractions. These fractions have high antioxidant potential. E. malaccensis L. seeds showed the largest DPPH radical scavenger capacity (EC50 = 22.62). The fractions of E. malaccensis L. leaves showed lower antioxidant capacity. The samples did not alter the profile of proinflammatory cytokines and nitric oxide release. The results indicate that species of the family Myrtaceae are rich in compounds with antioxidant capacity, which can help reduce the inflammatory response.
authors.affiliation: Laboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil.
authors.forename: Evellyne de Oliveira
authors.initials: Ede O
authors.lastname: Figueirôa
authors.forename: Luís Cláudio
authors.initials: LC
authors.lastname: Nascimento da Silva
authors.forename: Cristiane Moutinho Lagos
authors.initials: CM
authors.lastname: de Melo
authors.forename: Juliana Kelle de Andrade Lemoine
authors.initials: JK
authors.lastname: Neves
authors.forename: Nicácio Henrique
authors.initials: NH
authors.lastname: da Silva
authors.forename: Valéria Rêgo Alves
authors.initials: VR
authors.lastname: Pereira
authors.forename: Maria Tereza dos Santos
authors.initials: MT
authors.lastname: Correia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002477:Cells / Q000187:drug effects*; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis; D005419:Flavonoids / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000737:chemistry; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols / Q000032:analysis*; D012639:Seeds / Q000737:chemistry; D027842:Syzygium / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016207:Cytokines; D005419:Flavonoids; D010851:Picrates; D010936:Plant Extracts; D059808:Polyphenols; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl