title: Contributory role of viral infection in congenital tumour development.
abstract: Congenital tumours are a group of distinct infrequent disorders whose exact aetiologies have not clearly been understood so far. Viral infection seems to be one of the key factors involved in the carcinogenesis of certain tumours. This study was performed to assess whether viral DNAs are present in the congenital tumours or not. Nucleic acid from 31 congenital tumours was extracted. Detection of Epstein-Barr virus, Cytomegalovirus (CMV), adenovirus, Herpes simplex virus 1 (HSV1) and 2, Human herpes virus 6 (HHV6), and BK virus was performed using polymerase chain reaction. Viral nucleic acid was detected in eight subjects (25.8%), mostly adenovirus, CMV, and HHV6. Despite their low frequencies, a possible role could be identified for viral infections in tumour development or progression.
authors.affiliation: Department of Pathology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran 1419733151, Iran ; Tehran University of Medical Sciences, Infectious Disease Research Center, Tehran 1419733151, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Monajemzadeh
authors.forename: Soheila
authors.initials: S
authors.lastname: Sarmadi
authors.forename: Maryam
authors.initials: M
authors.lastname: Moeini
authors.forename: Mohammad
authors.initials: M
authors.lastname: Vasei
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
authors.forename: Ata
authors.initials: A
authors.lastname: Abbasi
authors.forename: Reza
authors.initials: R
authors.lastname: Shahsiah
authors.forename: Parin
authors.initials: P
authors.lastname: Tanzifi
authors.forename: Maryam
authors.initials: M
authors.lastname: Eghbali
keywords: PCR; congenital tumor; viral infection; virus