title: Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness.
abstract: Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Methods. Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained. Results. The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P = 0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL); P < 0.0001) and glycated hemoglobin HbA1c (GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3; P < 0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups. Conclusion. Our data indicate that the persistent hyperglycemia in GCK-MODY is associated with a low risk of developing diabetic macrovascular complications.
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, 150 06 Prague, Czech Republic.
authors.forename: Stepanka
authors.initials: S
authors.lastname: Pruhova
authors.forename: Petra
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authors.lastname: Dusatkova
authors.forename: Pavel J
authors.initials: PJ
authors.lastname: Kraml
authors.forename: Michal
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authors.lastname: Kulich
authors.forename: Zdena
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authors.lastname: Prochazkova
authors.forename: Jan
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authors.lastname: Broz
authors.forename: Jaroslav
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authors.lastname: Zikmund
authors.forename: Ondrej
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authors.lastname: Cinek
authors.forename: Michal
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authors.lastname: Andel
authors.forename: Oluf
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authors.lastname: Pedersen
authors.forename: Torben
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authors.lastname: Hansen
authors.forename: Jan
authors.initials: J
authors.lastname: Lebl