title: Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.
abstract: Apoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects. While the involved immune mechanisms are still being deciphered, apoptotic cell infusion has been tested in different experimental models where inflammation is deregulated. This includes chronic and acute inflammatory disorders such as arthritis, contact hypersensitivity and acute myocardial infarction. Apoptotic cell infusion has also been used in transplantation settings to prevent or treat acute and chronic rejection, as well as to limit acute graft-versus-host disease associated with allogeneic hematopoietic cell transplantation. Here, we review the mechanisms involved in apoptotic cell-induced immunomodulation and data obtained in preclinical models of transplantation and inflammatory diseases.
authors.affiliation: INSERM UMR1098, F25020 Besançon cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Saas
authors.forename: Sandra
authors.initials: S
authors.lastname: Kaminski
authors.forename: Sylvain
authors.initials: S
authors.lastname: Perruche
mesh_terms: D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy / Q000639:trends; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy; D023421:Models, Animal; D014180:Transplantation