title: A mathematical model of chlamydial infection incorporating movement of chlamydial particles.
abstract: We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.
authors.affiliation: Mathematical Sciences School, Queensland University of Technology, GPO Box 2434, Brisbane, Qld, 4001, Australia, dg.mallet@qut.edu.au.
authors.forename: Dann G
authors.initials: DG
authors.lastname: Mallet
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Bagher-Oskouei
authors.forename: A Charisse
authors.initials: AC
authors.lastname: Farr
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Simpson
authors.forename: Kelly-Jean
authors.initials: KJ
authors.lastname: Sutton
mesh_terms: D000818:Animals; D002690:Chlamydia Infections / Q000276:immunology / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000276:immunology; D003198:Computer Simulation; D005835:Genitalia / Q000382:microbiology; D006801:Humans; D055641:Mathematical Concepts; D008954:Models, Biological