title: Genetic polymorphism of angiotensin converting enzyme and risk of coronary restenosis after percutaneous transluminal coronary angioplasties: evidence from 33 cohort studies.
abstract: BACKGROUND
  In the past decade, a number of cohort studies studies have been carried out to investigate the relationship between the insertion/deletion polymorphism of the gene encoding angiotensin-converting enzyme and risk of restenosis after percutaneous transluminal coronary angioplasties in patients. However, these studies have yielded contradictory results. Genetic association studies addressing this issue are frequently hampered by insufficient power. We therefore performed a meta-analysis of the published studies to clarify this inconsistency and to establish a comprehensive picture of the relationship between ACE I/D polymorphism and post-PTCA restenosis risk.
  
  
  METHODS
  Databases including Pubmed, EMBASE, ISI Web of Science, EBSCO, Cochrane Library databases and CNKI were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.
  
  
  RESULTS
  A total of 33 cohort studies involving 11,099 subjects were included. In a combined analysis, the OR for post-PTCA restenosis of the ACE DD genotype was 1.61 (95% CI: 1.27-2.04; P<10(-5)). In the subgroup analysis by intervention, significantly increased risks were also found in PTCA-stent and PTCA-balloon for the DD genotype of the polymorphism.
  
  
  CONCLUSIONS
  Our meta-analysis showed that the DD genotype of ACE I/D polymorphism was significantly associated with increased risk of restenosis, particularly for PTCA-stent.
authors.affiliation: Department of Cardiology, The first people's hospital of Wenling, Wenling, Zhejiang, People's Republic of China.
authors.forename: Shen
authors.initials: S
authors.lastname: Wang
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dai
authors.forename: Lingling
authors.initials: L
authors.lastname: Chen
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Dong
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Zhong
authors.forename: Wenhui
authors.initials: W
authors.lastname: Lin
authors.forename: Jifu
authors.initials: J
authors.lastname: Zhang
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D023903:Coronary Restenosis / Q000453:epidemiology* / Q000235:genetics*; D016206:Databases, Bibliographic; D006801:Humans; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A