title: Expressions of Src homology 2 domain-containing phosphatase and its clinical significance in laryngeal carcinoma.
abstract: We investigated the expression of Src homology 2 domain-containing phosphatase (SHP-2) in laryngeal carcinoma and its clinical significance. Expression of SHP-2 was detected by immunohistochemical staining in normal mucosal tissues and various grades of laryngeal carcinoma. We looked for possible correlations between expression of SHP-2 in laryngeal carcinoma and clinical staging and lymph node metastasis. Immunochemical staining results revealed that the SHP-2 expression was significantly higher (88.24%) in laryngeal carcinoma than in normal mucosal tissue (25%). Additionally, the expression of SHP-2 was significantly correlated with lymph node metastasis, but not with clinical stage and gender of patients with laryngeal carcinoma. Therefore, SHP-2 may be useful as a prognostic marker for laryngeal carcinoma and as a therapeutic target in laryngeal carcinoma treatment.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The 455th Hospital of Chinese PLA, Shanghai, China cco1965@163.com.
authors.forename: L B
authors.initials: LB
authors.lastname: Dong
authors.forename: G Q
authors.initials: GQ
authors.lastname: Li
authors.forename: Z H
authors.initials: ZH
authors.lastname: Tian
authors.forename: Z M
authors.initials: ZM
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Xu
mesh_terms: D002277:Carcinoma / Q000201:enzymology* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D007830:Larynx / Q000201:enzymology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11