title: Medical influences, surgical outcomes: role of common medications on the risk of perforation from untreated diverticular disease.
abstract: Numerous drugs, largely used in the wards or at home, have a significant influence on patients with untreated diverticular disease. The consequences can be disastrous, may require an emergency operation, postoperative intensive care, and overall influence the patient's length of stay and the final outcomes. Bearing these considerations in mind the routine or chronic administration of pain-killers, steroids and non-steroidal anti-inflammatory should be balanced in patients with known diverticular disease as it normally happens with other conditions potentially affected by these drugs (i.e., peptic ulcer disease or chronic obstructive pulmonary disease). This is even more important in the old and frail patient where an eventual surgical treatment may not always be possible.
authors.affiliation: Gianpiero Gravante, Shuker Yahia, Department of Colorectal Surgery, George Eliot Hospital, Nuneaton CV10 7DJ, United Kingdom.
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Gravante
authors.forename: Shuker
authors.initials: S
authors.lastname: Yahia
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D004241:Diverticulum, Colon / Q000150:complications*; D016330:Frail Elderly; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced / Q000209:etiology*; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002121:Calcium Channel Blockers
keywords: Diverticular disease; Drugs; Medications; Perforation; Risk factor