title: Synthesis of benzimidazoles by potassium tert-butoxide-promoted intermolecular cyclization reaction of 2-iodoanilines with nitriles.
abstract: The synthesis of benzimidazoles by intermolecular cyclization reaction of 2-iodoanilines with nitriles has been developed. These reactions proceeded without the aid of any transition metals or ligands and just using KOBu(t) as the base. A variety of substituted benzimidazole derivatives can be synthesized by the approach.
authors.affiliation: College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, P. R. China. xiangsk@hotmail.com wangbiqin1964@126.com.
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Xiang
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Dong-Xue
authors.initials: DX
authors.lastname: Zhang
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Tian
authors.forename: Chun
authors.initials: C
authors.lastname: Feng
authors.forename: Bi-Qin
authors.initials: BQ
authors.lastname: Wang
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D000440:Butanols / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D009570:Nitriles / Q000737:chemistry*
chemical_list: C552400:2-iodobenzenamine; D000814:Aniline Compounds; D001562:Benzimidazoles; D000440:Butanols; D009570:Nitriles; C077664:tert-butoxide, potassium; C031000:benzimidazole