title: Role of PPARs in inflammatory processes associated with metabolic syndrome (Review).
abstract: Metabolic syndrome (MS) includes the presence of arterial hypertension, insulin resistance, dyslipidemia, cardiovascular disease (CVD) and abdominal obesity, which is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of certain pro-inflammatory signaling pathways. Furthermore, the changes presented by the adipose tissue in MS favors the secretion of several molecular mediators capable of activating or suppressing a number of transcription factors, such as the peroxisome proliferator-activated receptors (PPARs), whose main functions include storage regulation and fatty acid catabolization. When they are activated by their ligands (synthetic or endogenous), they control several genes involved in intermediate metabolism, which make them, together with the PPAR gamma coactivator-1-α (PGC-1) and the silent information regulator T1 (SIRT1), good targets for treating metabolic diseases and their cardiovascular complications.
authors.affiliation: Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fuentes
authors.forename: Luis
authors.initials: L
authors.lastname: Guzmán-Jofre
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Moore-Carrasco
authors.forename: Iván
authors.initials: I
authors.lastname: Palomo
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D024821:Metabolic Syndrome / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors
keywords: eroxisome     proliferator-activated     receptors; inflammation; adipocytes; metabolic syndrome