title: Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus.
abstract: Chemical examination of an arctic actinomycete Streptomyces nitrosporeus resulted in the isolation of two new alkaloids named nitrosporeusines A (1) and B (2), an unprecedented skeleton containing benzenecarbothioc cyclopenta[c]pyrrole-1,3-dione. Their structures were determined through extensive spectroscopic analyses in association with X-ray single crystal diffraction. Both 1 and 2 exhibited inhibitory activities against the H1N1 virus in MDCK cells.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P. R. China , The First Institute of Oceannography SOA , Qingdao 266061, P. R. China , and Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University , 40225 Duesseldorf, Germany.
authors.forename: Aigang
authors.initials: A
authors.lastname: Yang
authors.forename: Longlong
authors.initials: L
authors.lastname: Si
authors.forename: Zhenping
authors.initials: Z
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Demin
authors.initials: D
authors.lastname: Zhou
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D013438:Sulfhydryl Compounds; C587563:nitrosporeusine A; C587564:nitrosporeusine B