title: Effects of bone marrow mesenchymal stromal cells on gross motor function measure scores of children with cerebral palsy: a preliminary clinical study.
abstract: OBJECTIVE
  Pre-clinical evidence indicates that autologous bone marrow-derived mesenchymal stromal cell (BM-MSC) transplantation improves motor function in patients with central nervous system disorders.
  
  
  METHODS
  After providing informed consent, 52 patients with cerebral palsy (CP) who met the study criteria received BM-MSC transplantation. Gross motor function was assessed using the Gross Motor Function Measure (GMFM)-88 and GMFM-66 scales at baseline (before transplantation) and at 1 month, 6 months and 18 months post-transplantation. The participants completed the trial without visible side effects. The GMFM-66 percentile (motor growth curves) was used as the control index of motor function to exclude the interference of improvement with age.
  
  
  RESULTS
  The score domains A, B, C and D and the total GMFM-88 and GMFM-66 scores in participants increased at 1 month, 6 months and 18 months post-transplantation compared with the baseline value (P < 0.01). The scores of domain E also increased at 6 months and 18 months post-transplantation, although they were not significantly increased at 1 month post-transplantation. There were significant increases in the GMFM-66 score and the GMFM-66 percentile corresponding to patient age and Gross Motor Function Classification System level after cell transplantation.
  
  
  CONCLUSIONS
  Autologous BM-MSC transplantation appears to be a feasible, safe and effective therapy for patients with CP. The treatment improved the development of children with CP with regard to motor function.
authors.affiliation: Department of Stem Cell Transplantation, General Hospital of Chinese People's Armed Police Forces, Beijing, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Hongbin
authors.initials: H
authors.lastname: Cheng
authors.forename: Rongrong
authors.initials: R
authors.lastname: Hua
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Guanghui
authors.initials: G
authors.lastname: Dai
authors.forename: Zan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
authors.forename: Yihua
authors.initials: Y
authors.lastname: An
mesh_terms: D000293:Adolescent; D001854:Bone Marrow Cells / Q000166:cytology; D002547:Cerebral Palsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009043:Motor Activity / Q000502:physiology*; D012720:Severity of Illness Index; D014182:Transplantation, Autologous; D016896:Treatment Outcome
keywords: central nervous system; cerebral palsy; gross motor function; mesenchymal stem cell