title: Elevated serum ferritin level is associated with the incident type 2 diabetes in healthy Korean men: a 4 year longitudinal study.
abstract: BACKGROUND
  Elevated ferritin concentration has been implicated in the etiology of type 2 diabetes. Accumulating evidence, mostly from studies conducted on western populations, has demonstrated a strong association between the elevated ferritin concentrations and incident type 2 diabetes. In Asian populations, however, the longitudinal studies investigating the association of elevated serum ferritin levels and type 2 diabetes are lacking. In present study, we aimed to determine whether elevated serum ferritin levels are related to the incident type 2 diabetes in healthy Korean men.
  
  
  RESULTS
  This 4 year longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 2,029 men without type 2 diabetes who underwent routine health examination in 2007 (baseline) and 2011 (follow-up). Baseline serum ferritin concentrations were measured by chemiluminescent two-site sandwich immunoassay. In multiple-adjusted model, the relative risk (RR) for incident type 2 diabetes was significantly higher in highest compared with the lowest ferritin quartile category, even after adjusting for confounding variables including homeostasis model assessment of insulin resistance (RR = 2.17, 95% confidence interval 1.27-3.72, P for trend = 0.013).
  
  
  CONCLUSIONS
  These results demonstrated that elevated level of serum ferritin at baseline was associated with incident type 2 diabetes in an Asian population.
authors.affiliation: Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Jenie Yoonoo
authors.initials: JY
authors.lastname: Hwang
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Jang
authors.forename: Jaechan
authors.initials: J
authors.lastname: Leem
authors.forename: Joong-Yeol
authors.initials: JY
authors.lastname: Park
authors.forename: JungBok
authors.initials: J
authors.lastname: Lee
authors.forename: Hong-Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Woo Je
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D008137:Longitudinal Studies; D008297:Male; D056910:Republic of Korea / Q000453:epidemiology; D018709:Statistics, Nonparametric
chemical_list: D005293:Ferritins