title: Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement.
abstract: OBJECTIVE
  Establish how neutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT).
  
  
  METHODS
  A total of 38 pre-term infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curves were generated for CD64 counts at various threshold values.
  
  
  RESULTS
  PRU curves reduced the residual uncertainty of the presence of infection by up to 64%.
  
  
  CONCLUSIONS
  The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Neonatal Service, Royal Victoria Infirmary , Newcastle upon Tyne , United Kingdom.
authors.forename: Janet Elizabeth
authors.initials: JE
authors.lastname: Berrington
authors.forename: Richard Iain
authors.initials: RI
authors.lastname: Hearn
authors.forename: Chris
authors.initials: C
authors.lastname: Hall
authors.forename: Christopher James
authors.initials: CJ
authors.lastname: Stewart
authors.forename: Stephen Paul
authors.initials: SP
authors.lastname: Cummings
authors.forename: Nicholas David
authors.initials: ND
authors.lastname: Embleton
mesh_terms: D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000175:diagnosis; D009504:Neutrophils / Q000378:metabolism*; D019095:Point-of-Care Systems; D017452:Receptors, IgG / Q000097:blood*; D018805:Sepsis / Q000097:blood / Q000175:diagnosis; D035501:Uncertainty
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG; D002097:C-Reactive Protein