title: Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
abstract: Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.
authors.affiliation: Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD 21224, USA.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jimenez-Gomez
authors.forename: Julie A
authors.initials: JA
authors.lastname: Mattison
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Pearson
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martin-Montalvo
authors.forename: Hector H
authors.initials: HH
authors.lastname: Palacios
authors.forename: Alex M
authors.initials: AM
authors.lastname: Sossong
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Ward
authors.forename: Caitlin M
authors.initials: CM
authors.lastname: Younts
authors.forename: Kaitlyn
authors.initials: K
authors.lastname: Lewis
authors.forename: Joanne S
authors.initials: JS
authors.lastname: Allard
authors.forename: Dan L
authors.initials: DL
authors.lastname: Longo
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Belman
authors.forename: Maria M
authors.initials: MM
authors.lastname: Malagon
authors.forename: Placido
authors.initials: P
authors.lastname: Navas
authors.forename: Mitesh
authors.initials: M
authors.lastname: Sanghvi
authors.forename: Ruin
authors.initials: R
authors.lastname: Moaddel
authors.forename: Edward M
authors.initials: EM
authors.lastname: Tilmont
authors.forename: Richard L
authors.initials: RL
authors.lastname: Herbert
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Morrell
authors.forename: Josephine M
authors.initials: JM
authors.lastname: Egan
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Bogan
authors.forename: Michel
authors.initials: M
authors.lastname: Bernier
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D052436:Adipose Tissue, White / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002241:Carbohydrates; D002460:Cell Line; D059305:Diet, High-Fat; D007249:Inflammation / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008253:Macaca mulatta / Q000378:metabolism; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D059467:Transcriptome; D014781:Viscera / Q000378:metabolism / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002241:Carbohydrates; D007328:Insulin; D016328:NF-kappa B; D013267:Stilbenes; D056564:Sirtuin 1; D000077185:Resveratrol