title: [α-2β-adrenoreceptor gene polymorphism in patients with disorders of cardiac conduction].
abstract: The article is devoted to the role of insertion-deletion polymorphism of -2-adrenoreceptor gene in development of hereditary disorders of cardiac conduction. We examined 71 patients with atrioventricular blocks and 92 patients with sick sinus node syndrome. Statistically significant preponderance of homozygous genotype DD of ADRA2B gene was found in both groups. Associations of alleles with male or female gender were also revealed.
authors.affiliation: Krasnoyarsk State Medical University of prof. V.F. Vojno-Yasenetsky, ul. Partizana Zheleznyaka 1, 660022 Krasnoyarsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Chernova
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Nikulina
authors.forename: S S
authors.initials: SS
authors.lastname: Tret'iakova
authors.forename: V N
authors.initials: VN
authors.lastname: Maksimov
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
authors.forename: V N
authors.initials: VN
authors.lastname: Chernov
mesh_terms: D000328:Adult; D054537:Atrioventricular Block / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006329:Heart Conduction System / Q000503:physiopathology; D006720:Homozygote; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012720:Severity of Illness Index; D012737:Sex Factors; D012800:Siberia; D012804:Sick Sinus Syndrome / Q000235:genetics* / Q000503:physiopathology
chemical_list: C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2