title: Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients.
abstract: This study assesses complexity of cardiovascular control in patients affected by type-1 variant of long QT (LQT1) syndrome. Complexity was assessed by refined multiscale entropy of heart period (HP) and QT interval variabilities. HP was taken as the time distance between two consecutive R peaks (RR) and QT interval was approximated as the time distance between the R-peak and T-wave apex (RTa) and between R-peak and T-wave end (RTe). RR, RTa and RTe intervals were automatically extracted from 24h Holter recordings and the daytime period was analyzed (from 02:00 to 06:00 PM). Non mutation carrier (NMC) individuals (n=11), utilized as a control group, were taken from the same family line of the mutation carrier (MC) subjects (n=26). We found that, while NMC and MC groups were indistinguishable based on time domain and complexity analyses of RR dynamics, complexity analysis of RTa and RTe variabilities clearly separates the two populations and suggests an impairment in the cardiac control mechanisms acting on the ventricles.
authors.forename: Vlasta
authors.initials: V
authors.lastname: Bari
authors.forename: Jose F
authors.initials: JF
authors.lastname: Valencia
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vallverdu
authors.forename: Giulia
authors.initials: G
authors.lastname: Girardengo
authors.forename: Tito
authors.initials: T
authors.lastname: Bassani
authors.forename: Andrea
authors.initials: A
authors.lastname: Marchi
authors.forename: Laura
authors.initials: L
authors.lastname: Calvillo
authors.forename: Pere
authors.initials: P
authors.lastname: Caminal
authors.forename: Sergio
authors.initials: S
authors.lastname: Cerutti
authors.forename: Paul A
authors.initials: PA
authors.lastname: Brink
authors.forename: Lia
authors.initials: L
authors.lastname: Crotti
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Schwartz
authors.forename: Alberto
authors.initials: A
authors.lastname: Porta
mesh_terms: D004562:Electrocardiography; D019277:Entropy; D006321:Heart / Q000503:physiopathology*; D006579:Heterozygote; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics / Q000503:physiopathology*; D009154:Mutation / Q000235:genetics