title: [Comparison of the IL-27 level in gingival crevicular fluid of cross-quadrant and the upper and lower half-mouth subgingival scaling].
abstract: OBJECTIVE
  To investigate the changes of IL-27 in gingival crevicular fluid (GCF) before and after treatment with different methods for chronic periodontitis.
  
  
  METHODS
  Sixty patients with moderate or severe chronic periodontitis were selected as study group to divide into group A (cross-quadrant) and group B (upper and lower half-mouth) randomly. Another 30 healthy people were selected as group C. Gingival crevicular fluid of group A and B were collected at baseline and each week during treatment. At the same time, the clinical parameters including PD, AL, BI and PLI were recorded. And the levels of IL-27 in GCF were measured by ELISA. SPSS 17.0 software package was used for statistical analysis.
  
  
  RESULTS
  The levels of IL-27 in GCF 2 and 3 weeks after treatment were higher in study group compared with those at baseline, while PD, AL, BI and PLI showed significant reduction. The changes except PLI in group A was more obvious than group B, which had a significant difference. After three-week treatment, IL-27 in group A had no remarkable difference compared with group C. There were significantly negative correlation between PD, AL, BI, PLI and IL-27.
  
  
  CONCLUSIONS
  IL-27 in GCF can be considered as a potential target for prevention and treatment of chronic periodontitis. Compared with the upper and lower half-mouth subgingival scaling, cross-quadrant has more pronounced short-term effect.
authors.affiliation: .Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province;China.E-mail: hanjia1016@163.com.
authors.forename: Jia-jia
authors.initials: JJ
authors.lastname: Han
authors.forename: Ming-peng
authors.initials: MP
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Di-xin
authors.initials: DX
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Fang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Lin
mesh_terms: D055113:Chronic Periodontitis; D012534:Dental Scaling; D005883:Gingival Crevicular Fluid; D006801:Humans; D007378:Interleukins; D010518:Periodontitis
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human