title: High-risk features in radiation-associated breast angiosarcomas.
abstract: BACKGROUND
  Radiation-associated breast angiosarcoma (RT-AS) is an uncommon malignancy with an incidence of less than 1 % of all soft tissue sarcomas. The overall prognosis is quite dismal with high rates of recurrences and poor overall survival. There is an obvious paucity of data regarding clinical outcomes of patients with breast RT-AS.
  
  
  METHODS
  We identified all patients with RT-AS treated at the Memorial Sloan-Kettering Cancer Center between 1982-2011 and collected their correlative clinical information.
  
  
  RESULTS
  We identified 79 women with RT-AS with a median age of 68 (range 36-87). The median interval between radiation and development of RT-AS was 7 years (range 3-19). The median time to local and distant recurrence was 1.29 years (95 % CI 0.72-NA) and 2.48 years (95 % CI 1.29-NA), respectively. The median disease-specific survival was 2.97 years (95 % CI 2.21-NA). Independent predictors of worse disease-specific survival included age 68 years (HR 3.11, 95 % CI 1.20-8.08, P=0.020) and deep tumors (HR 3.23, 95 % CI 1.02-10.21, P=0.046.)
  
  
  CONCLUSIONS
  RT-AS has high local/distant recurrence rates, limited duration on standard chemotherapy and poor disease-specific survival.
authors.affiliation: 1] Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA [2] Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: D'Angelo
authors.forename: C R
authors.initials: CR
authors.lastname: Antonescu
authors.forename: D
authors.initials: D
authors.lastname: Kuk
authors.forename: L
authors.initials: L
authors.lastname: Qin
authors.forename: N
authors.initials: N
authors.lastname: Moraco
authors.forename: R C
authors.initials: RC
authors.lastname: Carvajal
authors.forename: P
authors.initials: P
authors.lastname: Chi
authors.forename: M A
authors.initials: MA
authors.lastname: Dickson
authors.forename: M
authors.initials: M
authors.lastname: Gounder
authors.forename: M L
authors.initials: ML
authors.lastname: Keohan
authors.forename: S
authors.initials: S
authors.lastname: Singer
authors.forename: G K
authors.initials: GK
authors.lastname: Schwartz
authors.forename: W D
authors.initials: WD
authors.lastname: Tap
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D016896:Treatment Outcome