title: Chemotherapy causes cancer! A case report of therapy related acute myeloid leukaemia in early stage breast cancer.
abstract: Use of chemotherapy and radiotherapy in the adjuvant setting has improved survival for many patients with malignancy. Unfortunately multimodality treatment can come at a price, in particular therapy-related malignancies. This has importance in that patients must be made aware of this potential detriment from therapy and doctors must consider this diagnosis in those patients who are cancer survivors and presenting with health problems. We present a case report and brief overview of the literature regarding chemotherapy-induced acute myeloid leukaemia (AML) following therapy for early stage breast cancer.
authors.affiliation: Northern Ireland Cancer Centre, Belfast City Hospital, Lisburn Road. Belfast BT9 7AB.
authors.forename: J Cole
authors.initials: JC
authors.lastname: Aidan
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Priddee
authors.forename: James J
authors.initials: JJ
authors.lastname: McAleer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008408:Mastectomy; D008875:Middle Aged; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D013629:Tamoxifen; D004317:Doxorubicin; D003520:Cyclophosphamide
keywords: adjuvant chemotherapy; breast cancer; therapy-related leukaemia