title: Priapism induced by boceprevir-CYP3A4 inhibition and α-adrenergic blockade: case report.
abstract: A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional α-adrenergic blockade.
authors.affiliation: Department of Pharmaceutical Sciences.
authors.forename: Kyle P
authors.initials: KP
authors.lastname: Hammond
authors.forename: Craig
authors.initials: C
authors.lastname: Nielsen
authors.forename: Sunny A
authors.initials: SA
authors.lastname: Linnebur
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Langness
authors.forename: Graham
authors.initials: G
authors.lastname: Ray
authors.forename: Paul
authors.initials: P
authors.lastname: Maroni
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Kiser
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D051544:Cytochrome P-450 CYP3A; D065692:Cytochrome P-450 CYP3A Inhibitors; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011317:Priapism / Q000175:diagnosis* / Q000209:etiology* / Q000601:surgery; D011392:Proline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D065692:Cytochrome P-450 CYP3A Inhibitors; D011942:Receptors, Adrenergic, alpha; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide; D011392:Proline; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human
keywords: boceprevir; drug interaction; priapism; quetiapine; α-adrenergic