title: Application of graphene-ionic liquid-chitosan composite-modified carbon molecular wire electrode for the sensitive determination of adenosine-5'-monophosphate.
abstract: In this paper, a graphene (GR) ionic liquid (IL) 1-octyl-3-methylimidazolium hexafluorophosphate and chitosan composite-modified carbon molecular wire electrode (CMWE) was fabricated by a drop-casting method and further applied to the sensitive electrochemical detection of adenosine-5'-monophosphate (AMP). CMWE was prepared with diphenylacetylene (DPA) as the modifier and the binder. The properties of modified electrode were examined by scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. Electrochemical behaviors of AMP was carefully investigated with enhanced responses appeared, which was due to the presence of GR-IL composite on the electrode surface with excellent electrocatalytic ability. A well-defined oxidation peak of AMP appeared at 1.314 V and the electrochemical parameters were calculated by electrochemical methods. Under the selected conditions, the oxidation peak current of AMP was proportional to its concentration in the range from 0.01 μM to 80.0 μM with the detection limit as 3.42 nM (3σ) by differential pulse voltammetry. The proposed method exhibited good selectivity and was applied to the detection of vidarabine monophosphate injection samples with satisfactory results.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Shi
authors.forename: Shixing
authors.initials: S
authors.lastname: Gong
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Zhu
authors.forename: Zhenfan
authors.initials: Z
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
mesh_terms: D000249:Adenosine Monophosphate / Q000032:analysis* / Q000592:standards; D002138:Calibration; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D048271:Chitosan / Q000737:chemistry*; D058266:Dielectric Spectroscopy; D055664:Electrochemical Techniques / Q000592:standards; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D010084:Oxidation-Reduction; D013499:Surface Properties
chemical_list: C446740:1-octyl-3-methylimidazolium hexafluorophosphate; D007093:Imidazoles; D052578:Ionic Liquids; D000249:Adenosine Monophosphate; D002244:Carbon; D006108:Graphite; D048271:Chitosan
keywords: 1-Octyl-3-methylimidazolium hexafluorophosphate; Adenosine-5′-monophosphate; Carbon molecular wire electrode; Cyclic voltammetry; Graphene