title: Relation between serum total bilirubin levels and severity of coronary artery disease in patients with non-ST-segment elevation myocardial infarction.
abstract: We studied 403 consecutive patients with non-ST-segment elevation myocardial infarction (NSTEMI). This population was divided into tertiles according to the SYNTAX score (SXscore). The high SXscore group was defined as an SXscore ≥13, and the low SXscore group as an SXscore <13. The total bilirubin (sTB) and direct bilirubin levels of patients were significantly higher in the high SXscore group (P = .001 and P = .007, respectively). There was a correlation between sTB and SXscore (r = .495; P = .005). On multivariate linear regression analyses, age (β = .100; P = .041), sTB levels (β = .171; P = .005), low-density lipoprotein cholesterol (β = .121; P = .014), and troponin-I (β = .124; P = .011) remained independent correlates of high SXscore. The mean follow-up period was 18.2 months. All-cause mortality rate was higher in the high SXscore group but did not reach significance (P = .058). In conclusion, high sTB level is independently associated with severity of coronary artery disease in patients with NSTEMI. However, no association was found with long-term mortality.
authors.affiliation: 1Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.forename: Omer
authors.initials: O
authors.lastname: Sahin
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Onur Kadir
authors.initials: OK
authors.lastname: Uysal
authors.forename: Serhat
authors.initials: S
authors.lastname: Karadavut
authors.forename: M Said
authors.initials: MS
authors.lastname: Cosgun
authors.forename: Goktug
authors.initials: G
authors.lastname: Savas
authors.forename: Ahmet Oguz
authors.initials: AO
authors.lastname: Baktir
authors.forename: Bahadir
authors.initials: B
authors.lastname: Sarli
authors.forename: Yat Yin
authors.initials: YY
authors.lastname: Lam
mesh_terms: D000367:Age Factors; D001663:Bilirubin / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D012044:Regression Analysis; D012720:Severity of Illness Index; D019210:Troponin I / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D019210:Troponin I; D001663:Bilirubin
keywords: SYNTAX score; bilirubin; coronary artery disease; non-ST-segment elevation myocardial infarction