title: Application of machine learning algorithms for clinical predictive modeling: a data-mining approach in SCT.
abstract: Data collected from hematopoietic SCT (HSCT) centers are becoming more abundant and complex owing to the formation of organized registries and incorporation of biological data. Typically, conventional statistical methods are used for the development of outcome prediction models and risk scores. However, these analyses carry inherent properties limiting their ability to cope with large data sets with multiple variables and samples. Machine learning (ML), a field stemming from artificial intelligence, is part of a wider approach for data analysis termed data mining (DM). It enables prediction in complex data scenarios, familiar to practitioners and researchers. Technological and commercial applications are all around us, gradually entering clinical research. In the following review, we would like to expose hematologists and stem cell transplanters to the concepts, clinical applications, strengths and limitations of such methods and discuss current research in HSCT. The aim of this review is to encourage utilization of the ML and DM techniques in the field of HSCT, including prediction of transplantation outcome and donor selection.
authors.affiliation: 1] The Division of Hematology and Bone Marrow Transplantation and Internal Medicine "F" Department, The Chaim Sheba Medical Center, Tel HaShomer, Israel [2] 2013 Pinchas Borenstein Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, Tel HaShomer, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Shouval
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Bondi
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Mishan
authors.affiliation: The Division of Hematology and Bone Marrow Transplantation and Internal Medicine "F" Department, The Chaim Sheba Medical Center, Tel HaShomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Shimoni
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Unger
authors.affiliation: The Division of Hematology and Bone Marrow Transplantation and Internal Medicine "F" Department, The Chaim Sheba Medical Center, Tel HaShomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nagler
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D019295:Computational Biology / Q000379:methods; D057225:Data Mining; D003663:Decision Trees; D006405:Hematology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016571:Neural Networks, Computer; D015203:Reproducibility of Results; D033581:Stem Cell Transplantation; D060388:Support Vector Machine