title: Daptomycin activity against uncommonly isolated streptococcal and other gram-positive species groups.
abstract: A total of 1,356 clinical isolates were tested against daptomycin by broth microdilution methods. Daptomycin was active against seven groups of viridans group streptococci (MIC50 and MIC90 values ranging from ≤0.06 and ≤0.06 μg/ml [Streptococcus bovis and Streptococcus dysgalactiae] to 0.5 and 1 μg/ml [Streptococcus mitis, Streptococcus oralis, and Streptococcus parasanguinis], respectively), beta-hemolytic streptococci serogroups C, F, and G (MIC50 and MIC90, ≤0.06 to 0.25 and 0.12 to 0.25 μg/ml, respectively), Corynebacterium spp. (MIC50 and MIC90, ≤0.06 and 0.12 μg/ml, respectively), and Micrococcus spp. (MIC50 and MIC90, ≤0.06 and 0.25 μg/ml, respectively). Listeria monocytogenes exhibited higher daptomycin MICs (MIC50 and MIC90, 2 and 4 μg/ml, respectively) than other tested organisms.
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Helio S
authors.initials: HS
authors.lastname: Sader
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
authors.forename: David J
authors.initials: DJ
authors.lastname: Farrell
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003352:Corynebacterium / Q000187:drug effects; D017576:Daptomycin / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013291:Streptococcus / Q000187:drug effects*; D016985:Streptococcus bovis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin