title: The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.
abstract: The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa. Sharon.prince@uct.ac.za.
authors.forename: Jade
authors.initials: J
authors.lastname: Peres
authors.forename: Sharon
authors.initials: S
authors.lastname: Prince
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D020825:T-Box Domain Proteins / Q000502:physiology*
chemical_list: D020825:T-Box Domain Proteins; C106884:TBX3 protein, human