title: Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles.
abstract: It stems from the magnetism: The extraction of stem/progenitor cells from the brain of live animals is possible using antibodies conjugated to magnetic nanoparticles (Ab-MNPs). The Ab-MNPs are introduced to a rat's brain with a superfine micro-syringe. The stem cells attach to the Ab-MNPs and are magnetically isolated and removed. They can develop into neurospheres and differentiate into different types of cells outside the subject body. The rat remains alive and healthy.
authors.affiliation: Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China).
authors.forename: C N P
authors.initials: CN
authors.lastname: Lui
authors.forename: Y P
authors.initials: YP
authors.lastname: Tsui
authors.forename: A S L
authors.initials: AS
authors.lastname: Ho
authors.forename: D K Y
authors.initials: DK
authors.lastname: Shum
authors.forename: Y S
authors.initials: YS
authors.lastname: Chan
authors.forename: C T
authors.initials: CT
authors.lastname: Wu
authors.forename: H W
authors.initials: HW
authors.lastname: Li
authors.forename: S C Edman
authors.initials: SC
authors.lastname: Tsang
authors.forename: K K L
authors.initials: KK
authors.lastname: Yung
mesh_terms: D000071916:AC133 Antigen; D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D001921:Brain / Q000166:cytology*; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism; D010316:Particle Size; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D051381:Rats; D044968:Regenerative Medicine
chemical_list: D000071916:AC133 Antigen; D000906:Antibodies; D015703:Antigens, CD; D006023:Glycoproteins; D058185:Magnetite Nanoparticles; D010455:Peptides
keywords: antibodies; magnetic nanoparticles; nanoparticles; regenerative medicine; stem cells