title: N,N'-alkylated Imidazolium-derivatives act as quorum-sensing inhibitors targeting the Pectobacterium atrosepticum-induced symptoms on potato tubers.
abstract: Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a chemical library of QS-inhibitors (QSIs) and AHL-analogs to find novel QSIs targeting the virulence of Pectobacterium. Four N,N'-bisalkylated imidazolium salts were identified as QSIs; they were active at the µM range. In potato tuber assays, two of them were able to decrease the severity of the symptoms provoked by P. atrosepticum. This work extends the range of the QSIs acting on the Pectobacterium-induced soft-rot disease.
authors.affiliation: Centre National de la Recherche Scientifique, Institut des Sciences du Végétal, UPR 2355, Gif-sur-Yvette 91198, France. faure@isv.cnrs-gif.fr.
authors.forename: Yannick Raoul
authors.initials: YR
authors.lastname: des Essarts
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sabbah
authors.forename: Arnaud
authors.initials: A
authors.lastname: Comte
authors.forename: Laurent
authors.initials: L
authors.lastname: Soulère
authors.forename: Yves
authors.initials: Y
authors.lastname: Queneau
authors.forename: Yves
authors.initials: Y
authors.lastname: Dessaux
authors.forename: Valérie
authors.initials: V
authors.lastname: Hélias
authors.forename: Denis
authors.initials: D
authors.lastname: Faure
mesh_terms: D015374:Biosensing Techniques; D044043:Pectobacterium / Q000187:drug effects* / Q000235:genetics; D035281:Plant Tubers / Q000382:microbiology*; D053038:Quorum Sensing / Q000187:drug effects*; D011198:Solanum tuberosum / Q000382:microbiology*; D014774:Virulence / Q000187:drug effects / Q000235:genetics