title: In vitro ultrasonic and mechanic characterization of the modulus of elasticity of children cortical bone.
abstract: The assessment of elastic properties in children's cortical bone is a major challenge for biomechanical engineering community, more widely for health care professionals. Even with classical clinical modalities such as X-ray tomography, MRI, and/or echography, inappropriate diagnosis can result from the lack of reference values for children bone. This study provides values for elastic properties of cortical bone in children using ultrasonic and mechanical measurements, and compares them with adult values. 18 fibula samples from 8 children (5-16 years old, mean age 10.6 years old ±4.4) were compared to 16 fibula samples from 3 elderly adults (more than 65 years old). First, the dynamic modulus of elasticity (Edyn) and Poisson's ratio (ν) are evaluated via an ultrasonic method. Second, the static modulus of elasticity (Esta) is estimated from a 3-point microbending test. The mean values of longitudinal and transverse wave velocities measured at 10 MHz for the children's samples are respectively 3.2mm/μs (±0.5) and 1.8mm/μs (±0.1); for the elderly adults' samples, velocities are respectively 3.5mm/μs (±0.2) and 1.9 mm/μs (±0.09). The mean Edyn and the mean Esta for the children's samples are respectively 15.5 GPa (±3.4) and 9.1 GPa (±3.5); for the elderly adults' samples, they are respectively 16.7 GPa (±1.9) and 5.8 GPa (±2.1). Edyn, ν and Esta are in the same range for children's and elderly adults' bone without any parametric statistical difference; a ranking correlation between Edyn and Esta is shown for the first time.
authors.affiliation: Laboratory of Mechanics and Acoustics (LMA), CNRS UPR 7051, Aix-Marseille University, Centrale Marseille, 31 Chemin Joseph-Aiguier, F-13402 Marseille cedex 20, France; Aix-Marseille University, CNRS, ISM UMR 7287, 13288 Marseille cedex 9, France. Electronic address: jph.berteau@gmail.com.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Berteau
authors.affiliation: Aix-Marseille University, CNRS, ISM UMR 7287, 13288 Marseille cedex 9, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Baron
authors.affiliation: Aix-Marseille University, CNRS, ISM UMR 7287, 13288 Marseille cedex 9, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Pithioux
authors.affiliation: Aix-Marseille University, CNRS, ISM UMR 7287, 13288 Marseille cedex 9, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Launay
authors.affiliation: Aix-Marseille University, CNRS, ISM UMR 7287, 13288 Marseille cedex 9, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Chabrand
authors.affiliation: Laboratory of Mechanics and Acoustics (LMA), CNRS UPR 7051, Aix-Marseille University, Centrale Marseille, 31 Chemin Joseph-Aiguier, F-13402 Marseille cedex 20, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lasaygues
mesh_terms: D000293:Adolescent; D000368:Aged; D001696:Biomechanical Phenomena; D002648:Child; D002675:Child, Preschool; D055119:Elastic Modulus; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D014463:Ultrasonography
keywords: Cortical bone; Elastic properties; Pediatrics; Ultrasonic wave velocities