title: FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus.
abstract: Regulatory T cells produce TGF-β that contributes to IgA induction by intestinal commensal bacteria but their importance in IgA responses to pathogens has not been determined. Immunity against the enteropathogen, rotavirus, is dependent on intestinal IgA, but whether FoxP3(+) regulatory T cells contribute to this IgA is unknown. Infection with rotavirus increased the numbers of intestinal FoxP3(+) regulatory T cells. Depletion of FoxP3(+) regulatory T cells altered leukocyte activation but did not significantly alter rotavirus clearance or specific antibody levels. These data suggest FoxP3(+) regulatory T cells are not critical for the early antibody response to rotavirus infection.
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Amber D
authors.initials: AD
authors.lastname: Miller
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Blutt
authors.affiliation: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. Electronic address: mconner@bcm.edu.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Conner
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D018655:Lymphocyte Count; D008212:Lymphocyte Depletion; D008297:Male; D051379:Mice; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology* / Q000821:virology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D000914:Antibodies, Viral; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse
keywords: FoxP3; IgA; Regulatory T cells; Rotavirus