title: Oxytocin and diabetes mellitus: a strong biochemical relation. Review.
abstract: Oxytocin (OXT) is a neurohypophysial hormone which is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus. OXT is currently attracting considerable attention because it has been discovered that it regulates various functions of behavior especially in the context of social interactions. OXT is a key component in bone formation, glycemia, male sexuality, cardiac differentiation and pregnancy and thus it is important to be further explored. The authors review various aspects of gestational diabetes, including definition, screening, diagnostic procedures, complications, clinical evaluation, indications of delivery and neonatal aspects. Not only the relation among diabetes mellitus, oxytocin and neurophysiology concerning erectile dysfunction, but also the role of OXT in the activity of arginine and vasopressin is investigated. It is imperative to develop technological and experimental methods that will be able to reveal the oxytocin and its potential.
authors.affiliation: Athens University Medical School, 1st Department of Psychiatry, Eginition, Hospital, 74 Vas Sofias Avenue, 11528, Athens, Greece. kontange@hol.gr.
authors.forename: K
authors.initials: K
authors.lastname: Kontoangelos
authors.forename: C C
authors.initials: CC
authors.lastname: Papageorgiou
authors.forename: A E
authors.initials: AE
authors.lastname: Raptis
authors.forename: A D
authors.initials: AD
authors.lastname: Rabavilas
authors.forename: G N
authors.initials: GN
authors.lastname: Papadimitriou
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D007743:Labor, Obstetric / Q000378:metabolism; D007774:Lactation / Q000187:drug effects; D008297:Male; D010120:Oxytocics / Q000008:administration & dosage / Q000378:metabolism*; D010121:Oxytocin / Q000008:administration & dosage / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000378:metabolism; D012919:Social Behavior
chemical_list: D010120:Oxytocics; D011956:Receptors, Cell Surface; D018045:Receptors, Oxytocin; C027786:glucose receptor; D001127:Arginine Vasopressin; D010121:Oxytocin