title: Four novel HLA alleles, DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22, identified in Brazilian individuals.
abstract: Four novel human leucocyte antigen (HLA) class II alleles were identified by sequencing-based typing (SBT) and analysis of the closest-matching alleles from volunteer subjects from the Brazilian Bone Marrow Donor Register (REDOME, Brazil). The new HLA alleles discovered include DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22. Three of the novel alleles had single-nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single-nucleotide polymorphism (SNP) identified as a silent substitution.
authors.affiliation: Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Departamento da Ciência da Computação, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; IMUNOLAB - Laboratório de, Imunologia de Transplantes, Belo Horizonte, MG, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Fabreti-Oliveira
authors.forename: E
authors.initials: E
authors.lastname: Nascimento
authors.forename: C K F
authors.initials: CK
authors.lastname: Oliveira
authors.forename: E M G
authors.initials: EM
authors.lastname: Vale
authors.forename: B
authors.initials: B
authors.lastname: Vilela
authors.forename: M A
authors.initials: MA
authors.lastname: Santos
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D001938:Brazil; D005091:Exons; D005260:Female; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D014019:Tissue Donors
chemical_list: D059811:HLA-DRB1 Chains