title: Inhibited apoptosis of C(2)C(1)2 myoblasts by a Eupatorium chinense var. simplicifolium root extract.
abstract: We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C(2)C(12) myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUC-pre-treated C(2)C(12) myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.
authors.affiliation: Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology, Yonsei University.
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Jung
authors.forename: Yong-Hyeon
authors.initials: YH
authors.lastname: Lee
authors.forename: Yusu
authors.initials: Y
authors.lastname: Shin
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Kim
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schreiber
authors.forename: Tack-Joong
authors.initials: TJ
authors.lastname: Kim
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D036602:Eupatorium / Q000737:chemistry*; D032446:Myoblasts / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D010936:Plant Extracts