title: Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant.
abstract: Despite recent advances in nonsteroidal anti-inflammatory drug (NSAID) formulations, the design of targeted delivery systems to improve the efficacy and reduce side effects of NSAIDs continues to be a focus of much research. Enteric nanoparticles have been recognized as a potential system to reduce gastrointestinal irritations caused by NSAIDs. The aim of this study was to evaluate the effect of EUDRAGIT® L100, polyethylene glycol, and polysorbate 80 on encapsulation efficiency of indomethacin within enteric nanoparticles. Formulations were developed based on a multilevel factorial design (three factors, two levels). The amount of polyethylene glycol was shown to be the factor that had the greatest influence on the encapsulation efficiency (evaluated response) at 95% confidence level. Some properties of nanoparticles like process yield, drug-polymer interaction, particle morphology, and in vitro dissolution profile, which could affect biological performance, have also been evaluated.
authors.affiliation: Laboratório de Pesquisa em Fármacos, Centro de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Brazil ; Programa de Pós-Graduação em Biodiversidade Tropical, Universidade Federal do Amapá, Brazil.
authors.forename: Danay
authors.initials: D
authors.lastname: Dupeyrón
authors.forename: Monique
authors.initials: M
authors.lastname: Kawakami
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Ferreira
authors.forename: Paolin Rocio
authors.initials: PR
authors.lastname: Cáceres-Vélez
authors.forename: Jacques
authors.initials: J
authors.lastname: Rieumont
authors.forename: Ricardo Bentes
authors.initials: RB
authors.lastname: Azevedo
authors.forename: José Carlos T
authors.initials: JC
authors.lastname: Carvalho
mesh_terms: D000042:Absorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053769:Nanocapsules; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D011092:Polyethylene Glycols; D007213:Indomethacin
keywords: enteric polymer; indomethacin; nanoparticles; nonsteroidal anti-inflammatory; polyethylene glycol