title: Construction of a biomimetic peroxynitrite-generating platform: a two-component system to synthesize peroxynitrite in situ under the control of light.
abstract: Surge protector: a two-component peroxynitrite-generating platform has been engineered to release peroxynitrite (PN) in situ under the control of light. The system, which is constructed by layering sol-gel matrices containing xanthine oxidase (bottom layer) and a metal nitrosyl (top layer), allows studies of PN chemistry at varying fluxes of its precursors.
authors.affiliation: Department of Chemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (USA).
authors.forename: Tara R
authors.initials: TR
authors.lastname: de Boer-Maggard
authors.forename: Angel
authors.initials: A
authors.lastname: Resendez
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism; D005782:Gels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008027:Light; D008345:Manganese / Q000737:chemistry; D009569:Nitric Oxide / Q000737:chemistry; D010084:Oxidation-Reduction; D030421:Peroxynitrous Acid / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013481:Superoxides / Q000737:chemistry; D014466:Ultraviolet Rays; D014969:Xanthine Oxidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D005782:Gels; D013481:Superoxides; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D008345:Manganese; D014969:Xanthine Oxidase
keywords: light control; multiwell platforms; nitric oxide; peroxynitrite; superoxides