title: Functionalization of polycarbonate surfaces by grafting PEG and zwitterionic polymers with a multicomb structure.
abstract: The hemocompatibility of polycarbonateurethane (PCU) surfaces is improved by decoration with poly(poly(ethylene glycol) methacrylate) (poly(PEGMA)) and zwitterionic poly(3-((2-(methacryloyloxy)ethyl)dimethylammonio)propane-1-sulfonate) (poly(DMAPS)) blocks providing a novel multicomb structure obtained by application of surface-initiated atom transfer radical polymerization (s-ATRP) conditions. The PCU-poly(PEGMA-g-DMAPS) surface shows high hydrophilicity with a low contact angle of 20.6 ± 1.8°, while PCU-poly(PEGMA-b-DMAPS) surface exhibitsed a contact angle of 30.5 ± 2.6°. Furthermore, PCU-poly(PEGMA-g-DMAPS) surface shows very low platelet adsorption indicating that multicomb structure modified PCUs are preferred candidate materials for blood-contacting materials.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, 300072, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Lv
authors.forename: Marc
authors.initials: M
authors.lastname: Behl
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
authors.forename: Dazhi
authors.initials: D
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Changcan
authors.initials: C
authors.lastname: Shi
authors.forename: Jintang
authors.initials: J
authors.lastname: Guo
authors.forename: Yakai
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002478:Cells, Cultured; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry*; D010973:Platelet Adhesiveness / Q000187:drug effects; D011076:Polycarboxylate Cement / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011109:Polymethacrylic Acids; D011140:Polyurethanes / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011817:Rabbits; D013499:Surface Properties
chemical_list: C530265:3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate; D001672:Biocompatible Materials; D008689:Methacrylates; D011076:Polycarboxylate Cement; D011109:Polymethacrylic Acids; D011140:Polyurethanes; D000644:Quaternary Ammonium Compounds; C528061:poly(poly(ethylene glycol)methacrylate); C005506:polycarbonate; D011092:Polyethylene Glycols
keywords: ATRP; biomaterials; graft copolymers; hemocompatibility; polyurethanes; zwitterionic polymer