title: Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery.
abstract: OBJECTIVE
  To examine the effect of the zedoary essential component-eluting stent (ZES) on a porcine coronary neointimal formation.
  
  
  METHODS
  ZES, sirolimus-eluting stents (SES), and bare metal stents (BMS) were randomly implanted in three different major epicardial vessels in 36 balloon-injured pigs. Coronary angiography, optical coherence tomography, and histomorphological analysis were used to determine antihyperplasia effects.
  
  
  RESULTS
  ZES and SES had a significantly larger lumen diameter and area, and reduced diameter and area of stenosis in arteries at 30 and 90 days compared with arteries implanted with BMS (P<0.01). Histomorphometric analysis showed moderate inflammatory responses, such as infiltration of mononuclear cells, lymphocytes, and multinucleated giant cells in some arteries with SES compared with ZES (P<0.05). Injury scores were not different among the three groups at 30 and 90 days. The endothelialization score in the SES group was 2.69 ± 0.42 at 30 days and 2.83 ± 0.39 at 90 days compared with the ZES and BMS groups (both were 3.00 ± 0.00 at either 30 or 90 days, P<0.05). Well developed endothelium was observed in the ZES group, while incomplete endothelium and inflammatory cells were observed with stent struts partly naked at the vessel lumen in the SES group.
  
  
  CONCLUSIONS
  The ZES inhibits neointimal hyperplasia with good endothelia coverage in the porcine balloon injury coronary model.
authors.affiliation: Cardiovascular Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Fu-hai
authors.initials: FH
authors.lastname: Zhao
authors.forename: Jian-gang
authors.initials: JG
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Da-wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Pei-li
authors.initials: PL
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Jian-peng
authors.initials: JP
authors.lastname: Du
authors.forename: Xin-zhi
authors.initials: XZ
authors.lastname: Li
authors.forename: Yan-lei
authors.initials: YL
authors.lastname: Ma
authors.forename: Yue
authors.initials: Y
authors.lastname: Shi
authors.forename: Da-zhuo
authors.initials: DZ
authors.lastname: Shi
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D023921:Coronary Stenosis / Q000473:pathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology*; D030024:Curcuma / Q000737:chemistry*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D007249:Inflammation / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D058426:Neointima / Q000473:pathology*; D019919:Prosthesis Implantation; D015607:Stents; D034421:Sus scrofa; D013997:Time Factors
chemical_list: D020099:Coated Materials, Biocompatible