title: Q-bodies monitor the quinary state of the protein fold.
abstract: Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.
authors.affiliation: The Scripps Research Institute, Department of Cell and Molecular Biology, 10555 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Daniela Martino
authors.initials: DM
authors.lastname: Roth
authors.forename: William E
authors.initials: WE
authors.lastname: Balch
mesh_terms: D000818:Animals; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D017510:Protein Folding; D055550:Protein Stability; D011506:Proteins / Q000737:chemistry*; D059748:Proteolysis; D015398:Signal Transduction
chemical_list: D006360:Heat-Shock Proteins; D011506:Proteins