title: High plasma adiponectin levels in patients with severe traumatic brain injury.
abstract: BACKGROUND
  Adiponectin plays an important role in the regulation of tissue inflammation. There is a paucity of data on circulating plasma adiponectin concentrations in human traumatic brain injury. This study is designed to investigate the potential associations between plasma adiponectin levels and clinical outcomes after traumatic brain injury.
  
  
  METHODS
  Plasma adiponectin levels of 86 patients with severe traumatic brain injury and 86 healthy subjects were determined. Clinical outcomes included in-hospital mortality, 6-month mortality and 6-month unfavorable outcome (Glasgow Outcome Scale score of 1-3).
  
  
  RESULTS
  Plasma adiponectin levels were significantly higher in patients compared to controls (20.5±5.9 vs. 7.7±2.0μg/ml; P<0.001) and emerged as an independent predictor of in-hospital mortality [odds ratio (OR), 1.318; 95% confidence interval (CI), 1.049-1.629; P=0.008], 6-month mortality (OR, 1.328; 95% CI, 1.082-1.657; P=0.007) and 6-month unfavorable outcome (OR, 1.240; 95% CI, 1.066-1.443; P=0.005) in a multivariate analysis. For predicting these clinical outcomes, areas under receiver operating characteristic curve of plasma adiponectin level were similar to those of Glasgow Coma scale scores (all P>0.05). However, adiponectin did not improve predictive values of Glasgow Coma scale scores (all P>0.05).
  
  
  CONCLUSIONS
  Plasma adiponectin level may represent a novel biomarker for predicting clinical outcomes of traumatic brain injury.
authors.affiliation: Department of Neurosurgery, Shengzhou People's Hospital, 208 Yiyuan Road, Shenzhou 312400, China. Electronic address: shengzhoushenlj@163.com.
authors.forename: Liang-Jun
authors.initials: LJ
authors.lastname: Shen
authors.forename: Song-Bin
authors.initials: SB
authors.lastname: Yang
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Lv
authors.forename: Guo-Hai
authors.initials: GH
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Mi
authors.initials: M
authors.lastname: Guo
authors.forename: Hang-Bin
authors.initials: HB
authors.lastname: Huang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.forename: Chun-Song
authors.initials: CS
authors.lastname: Yang
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055815:Young Adult
chemical_list: D052242:Adiponectin
keywords: Adiponectin; Biomarker; Prognosis; Traumatic brain injury