title: Zinc-mediated highly α-regioselective 1,4-addition of chalcones with prenyl bromide in THF.
abstract: α-Regioselective addition to chalcones was realized by use of in situ generated prenylzinc reagents from zinc and prenyl bromide in the presence of SnCl4 in a 1,4-addition fashion. The approach uses the reagent combination of prenyl bromide, zinc, and SnCl4 in THF, all of which are inexpensive, readily available, and easily removable after the reaction.
authors.affiliation: School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, Jiangsu, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhao
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Dou
authors.forename: Rui
authors.initials: R
authors.lastname: Sun