title: Serum fetuin-A levels following recombinant human thyroid-stimulating hormone stimulation.
abstract: OBJECTIVE
  Fetuin-A is a hepatokine that is linked to lipid metabolism, obesity, insulin resistance, type 2 diabetes and cardiovascular disease. Elevated thyroid-stimulating hormone (TSH) levels are associated with metabolic and cardiovascular disturbances. Our aim was to determine if TSH can regulate fetuin-A levels.
  
  
  METHODS
  Fetuin-A serum levels were examined in 26 subjects (19 women; previous thyroidectomy and radioactive iodine ablation) undergoing recombinant human TSH (rhTSH) stimulation to screen for thyroid cancer recurrence. Their age was 49±10 years, and body mass index (BMI) was 28±6 (both expressed as mean±SD). The patients received two doses of rhTSH (0.9 mg), administered 24 hours apart on days 1 and 2, without discontinuation of ongoing L-thyroxine therapy. Morning blood samples were obtained on days 1 (prior to the first dose of rhTSH), 3 and 5.
  
  
  RESULTS
  The baseline value of fetuin-A (mean±SD) for all participants was 527±186 mg/L. Values of fetuin-A did not change in response to rhTSH administration. The lack of response was not dependent on gender, age, baseline free thyroxine level or BMI.
  
  
  CONCLUSIONS
  Fetuin-A has been implicated in metabolic and inflammatory conditions, but there have been no reports on whether fetuin-A is influenced by TSH. Within the context of rhTSH administration for surveillance of thyroid cancer recurrence, there was no effect on serum levels of fetuin-A.
authors.affiliation: . asorisky@ohri.ca.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Gagnon
authors.forename: Hussein
authors.initials: H
authors.lastname: Abujrad
authors.forename: Clara
authors.initials: C
authors.lastname: Irobi
authors.forename: Heather A
authors.initials: HA
authors.lastname: Lochnan
authors.forename: Alexander
authors.initials: A
authors.lastname: Sorisky
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000517:prevention & control; D013964:Thyroid Neoplasms / Q000097:blood* / Q000628:therapy; D057073:Thyrotropin Alfa / Q000008:administration & dosage*; D013974:Thyroxine / Q000008:administration & dosage; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: C556354:AHSG protein, human; D057073:Thyrotropin Alfa; D060749:alpha-2-HS-Glycoprotein; D013974:Thyroxine