title: Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass.
abstract: In a prospective cohort of 181 individuals followed up since childhood--when aged 9, 12 and 15 years--patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood--at mean age of 31 years--compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m(2.7), p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; p(diff)=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; p(diff)=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.
authors.affiliation: 1Menzies Research Institute Tasmania,University of Tasmania,Hobart,Australia.
authors.forename: Costan G
authors.initials: CG
authors.lastname: Magnussen
authors.affiliation: 3Murdoch Childrens Research Institute,Melbourne,Australia.
authors.forename: Terence
authors.initials: T
authors.lastname: Dwyer
authors.affiliation: 1Menzies Research Institute Tasmania,University of Tasmania,Hobart,Australia.
authors.forename: Alison
authors.initials: A
authors.lastname: Venn
mesh_terms: D000293:Adolescent; D001315:Australia / Q000453:epidemiology; D002648:Child; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult