title: What's the Mtrr with your grandparents?
abstract: Reduced folate levels can cause developmental defects and megaloblastic anemia. Padmanabhan et al. (2013) show that mutation in mice of a folate metabolism gene, Mtrr, which encodes for methionine synthase reductase, causes developmental defects not only in the mutant progeny, but also in genetically wild-type descendants for up to four generations.
authors.affiliation: Division of Newborn Medicine, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Greer
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000818:Animals; D000013:Congenital Abnormalities / Q000235:genetics*; D004622:Embryo, Mammalian / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005260:Female; D005287:Ferredoxin-NADP Reductase / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000235:genetics*; D005492:Folic Acid / Q000378:metabolism*; D008297:Male
chemical_list: D005492:Folic Acid; D005287:Ferredoxin-NADP Reductase