title: Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs.
abstract: ABCC10, also known as multidrug-resistant protein 7 (MRP7), is the tenth member of the C subfamily of the ATP-binding cassette (ABC) superfamily. ABCC10 mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs. The ABCC10 transporter is a 171-kDa protein that is localized on the basolateral cell membrane. ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen. In recent years, ABCC10 inhibitors, including cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR. This review discusses some recent and clinically relevant aspects of the ABCC10 drug efflux transporter from the perspective of current chemotherapy, particularly its inhibition by tyrosine kinase inhibitors and phosphodiesterase type 5 inhibitors.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA. chenz@stjohns.edu.
authors.forename: Rishil J
authors.initials: RJ
authors.lastname: Kathawala
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Charles R
authors.initials: CR
authors.lastname: Ashby
authors.forename: Zhe-Sheng
authors.initials: ZS
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents; D001549:Benzamides; D044182:Benzylisoquinolines; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D000069347:Erlotinib Hydrochloride; D006801:Humans; D000068877:Imatinib Mesylate; D007093:Imidazoles; D000077341:Lapatinib; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000037:antagonists & inhibitors*; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D011799:Quinazolines; D000068677:Sildenafil Citrate; D013449:Sulfonamides; D013450:Sulfones; D043823:Taxoids; D014227:Triazines; D000069058:Vardenafil Dihydrochloride; D052117:Benzodioxoles
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D044182:Benzylisoquinolines; D000069347:Erlotinib Hydrochloride; D000068877:Imatinib Mesylate; D007093:Imidazoles; D000077341:Lapatinib; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D011799:Quinazolines; D000068677:Sildenafil Citrate; D013449:Sulfonamides; D013450:Sulfones; D043823:Taxoids; D014227:Triazines; D000069058:Vardenafil Dihydrochloride; C421142:ABCC10 protein, human; C006947:cepharanthine; D052117:Benzodioxoles; C498826:nilotinib