title: Cost-effectiveness of osteo-odonto keratoprosthesis in Singapore.
abstract: OBJECTIVE
  To determine the long-term cost-effectiveness of osteo-odonto keratoprosthesis (OOKP) relative to no treatment among patients with end-stage corneal and ocular surface diseases in Singapore.
  
  
  METHODS
  Cost-effectiveness analysis based on data from a retrospective cohort study.
  
  
  METHODS
  From a health system perspective, we calculated the incremental cost-effectiveness ratio of OOKP treatment relative to no treatment over a 30-year horizon, based on data from a cohort of 23 patients who underwent OOKP surgery between 2004 and 2009 at Singapore National Eye Centre. Preoperative and postoperative vision-related quality-of-life values were estimated from patients' visual outcomes and were used to calculate the gain in quality-adjusted life years (QALYs) resulting from OOKP treatment. Unsubsidized costs for surgery, consultations, examinations, medications, follow-up visits, and treatments for complications were retrieved from patients' bills to estimate the total costs associated with OOKP treatment. Sensitivity analyses were conducted to test the robustness of the model.
  
  
  RESULTS
  Over a 30-year period, OOKP treatment, compared with no treatment, improved QALYs by 3.991 among patients with end-stage corneal and ocular surface diseases at an additional cost of S$67 840 (US$55 150), resulting in an incremental cost-effectiveness ratio of S$17 000/QALY (US$13 820/QALY).
  
  
  CONCLUSIONS
  Based on commonly cited cost-effectiveness benchmarks, the OOKP is a cost-effective treatment for patients with end-stage corneal and ocular surface diseases.
authors.affiliation: Duke-NUS Graduate Medical School, Singapore, Republic of Singapore.
authors.forename: Di
authors.initials: D
authors.lastname: Dong
authors.affiliation: Singapore National Eye Centre, Singapore, Republic of Singapore; Singapore Eye Research Institute, Singapore, Republic of Singapore.
authors.forename: Anna
authors.initials: A
authors.lastname: Tan
authors.affiliation: Duke-NUS Graduate Medical School, Singapore, Republic of Singapore; Singapore National Eye Centre, Singapore, Republic of Singapore; Singapore Eye Research Institute, Singapore, Republic of Singapore. Electronic address: Jodmehta@gmail.com.
authors.forename: Jodhbir S
authors.initials: JS
authors.lastname: Mehta
authors.affiliation: Singapore National Eye Centre, Singapore, Republic of Singapore; Singapore Eye Research Institute, Singapore, Republic of Singapore.
authors.forename: Donald
authors.initials: D
authors.lastname: Tan
authors.affiliation: Duke-NUS Graduate Medical School, Singapore, Republic of Singapore.
authors.forename: Eric Andrew
authors.initials: EA
authors.lastname: Finkelstein
mesh_terms: D000328:Adult; D000539:Alveolar Process / Q000637:transplantation*; D064592:Autografts; D002057:Burns, Chemical / Q000191:economics* / Q000523:psychology / Q000601:surgery; D003266:Continuity of Patient Care; D003362:Cost-Benefit Analysis; D003481:Cuspid / Q000637:transplantation*; D003663:Decision Trees; D005126:Eye Burns / Q000139:chemically induced*; D005500:Follow-Up Studies; D017048:Health Care Costs; D006801:Humans; D011183:Postoperative Complications; D019736:Prostheses and Implants / Q000191:economics*; D011788:Quality of Life / Q000523:psychology; D019057:Quality-Adjusted Life Years; D012189:Retrospective Studies; D012846:Singapore; D013262:Stevens-Johnson Syndrome / Q000191:economics* / Q000523:psychology / Q000601:surgery; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology