title: Functional state of red blood system as a possible predictor of individual radiosensitivity and carcinogenesis.
abstract: Functional state of the red blood system is being studied in patients with adenoma and carcinoma of thyroid gland. The aim of this study was to determine the possible predictors of the individual radiosensitivity and the probability of developing cancer on the basis of the comparable characteristic of functional state of the red blood system in patients with adenoma and carcinoma of thyroid gland. Functional state of the red blood system is being studied in patients with adenoma and carcinoma of thyroid gland. The functional state of RBC was determined by using the specially developed method based on analysis of the dynamics of peripheral blood erythrocytes distribution according to their spherulation degree (Q) and volume (V). Spherulation degree is considered as biological age and along with the volume determines the probability of their elimination from circulating bed. In connection with these positions distribution P=P(V,Q) express mechanism of production-aging-elimination of RBC of peripheral blood in circulating conditions and according to their dynamics we can discuss about the character of these processes. Revelation of differences certainly indicates high heterogeneity by the quality of young fractions of RBC of peripheral blood in patients with cancer versus the patients with adenoma. This parameter may be determined as a marker of individual radiosensitivity and probability of developing cancer. However the issue about haemopoesis instability in patients with cancer, whether it is caused by genotype, phenotype or toxic action of products of disintegration of tumors, demands the further researches.
authors.affiliation: I. Beritashvili Center of Experimental Biomedicine; National Cancer Center of Georgia, Tbilisi, Georgia.
authors.forename: F
authors.initials: F
authors.lastname: Todua
authors.forename: G
authors.initials: G
authors.lastname: Ormotsadze
authors.forename: D
authors.initials: D
authors.lastname: Nadareishvili
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
authors.forename: K
authors.initials: K
authors.lastname: Mardaleishvili
mesh_terms: D000328:Adult; D063646:Carcinogenesis; D004912:Erythrocytes / Q000473:pathology* / Q000528:radiation effects; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D011836:Radiation Tolerance / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000532:radiotherapy