title: A case of skeletal and bone marrow metastases from breast cancer treated with eribulin mesylate.
abstract: OBJECTIVE
  We report our experience with eribulin mesylate in a pancytopenic heavily pretreated patient with multiple bone metastases and bone marrow infiltration from breast cancer.
  
  
  METHODS
  Eribulin mesylate was given at 1.4 mg/m(2) on day 1 and 8 every 3 weeks for a total of 11 courses.
  
  
  RESULTS
  After seven cycles, evaluation with a bone marrow biopsy showed a large decrease of neoplastic involvement with substitution of osteolitic lesions for the osteoaddensant type. No unexpected acute toxicity was observed.
  
  
  CONCLUSIONS
  To our knowledge, this represents the first report of bone marrow metastases from breast cancer treated with eribulin mesylate that obtained an improvement of hematopoietic values with an acceptable profile of tolerability and good compliance for the subject.
authors.affiliation: Department of Oncology, Haematology & Respiratory Diseases, University of Modena & Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.
authors.forename: Etleva
authors.initials: E
authors.lastname: Pashaj
authors.forename: Laura
authors.initials: L
authors.lastname: Cortesi
authors.forename: Manuela
authors.initials: M
authors.lastname: Proietto
authors.forename: Goretta
authors.initials: G
authors.lastname: Bonacorsi
authors.forename: Eliana
authors.initials: E
authors.lastname: Liardo
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D007659:Ketones / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013131:Spine / Q000473:pathology*; D016896:Treatment Outcome; D000095662:Polyether Polyketides
chemical_list: D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides