title: Drug-induced acute liver failure.
abstract: Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.
authors.affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, 5959 Harry Hines Boulevard, Suite 420, Dallas, TX 75390-8887, USA. Electronic address: William.Lee@utsouthwestern.edu.
authors.forename: William M
authors.initials: WM
authors.lastname: Lee
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000628:therapy
keywords: Coagulopathy; Encephalopathy; Hepatocyte injury; Liver transplantation