title: Optically-induced dielectrophoretic technology for cancer cells identification and concentration.
abstract: The detection and concentration of cancer cells in peripheral blood is of great importance for cancer diagnosis and prognosis. Optically-induced dielectrophoresis (ODEP) can achieve high resolution and low optical intensities, and the electrodes pattern can be dynamically changed by varied light pattern. In this paper, a special lens is used to project the entire image to the ODEP chip to achieve 2.6 × 2 mm(2) manipulating area. By changing projected light pattern, it is demonstrated to separate 10, 20, and 40 µm PS (polystyrene) beads; HT-29, 20 µm PS beads. The MCF-7 cells concentrated experiments are also demo at 100 µm/sec velocity.
authors.forename: Hsiu-Hsiang
authors.initials: HH
authors.lastname: Chen
authors.forename: Hsin-Hsiang
authors.initials: HH
authors.lastname: Lo
authors.forename: Chun-Chuan
authors.initials: CC
authors.lastname: Lin
authors.forename: Kuo-Yao
authors.initials: KY
authors.lastname: Weng
authors.forename: Jyh-Chern
authors.initials: JC
authors.lastname: Chen
mesh_terms: D002469:Cell Separation / Q000379:methods; D055088:Early Detection of Cancer; D004586:Electrophoresis / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D061986:MCF-7 Cells; D046210:Microfluidic Analytical Techniques; D009369:Neoplasms / Q000175:diagnosis*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*