title: Chemotherapy-induced hepatotoxicity.
abstract: Most hepatotoxicity secondary to chemotherapy is idiosyncratic and, therefore, neither dose dependent nor predictable. Some chemotherapy is cleared by the liver and requires dose adjustment in the face of significant liver dysfunction. In addition, preexisting abnormal liver function has been shown to increase the risk of hepatotoxicity. In addition to typical hepatocellular injury, other presentations, including cholestasis and hepatic sinusoidal obstruction syndrome, also commonly occur. The outcomes can range from asymptomatic liver function test abnormalities, which resolve spontaneously, to cirrhosis, which occurs despite discontinuation of the chemotherapeutic agent.
authors.affiliation: Department of Medicine, Memorial Health, University Medical Center, 4700 Waters Avenue, Savannah, GA 31403, USA.
authors.forename: Ameet V
authors.initials: AV
authors.lastname: Thatishetty
authors.forename: Nicholas
authors.initials: N
authors.lastname: Agresti
authors.forename: Christopher B
authors.initials: CB
authors.lastname: O'Brien
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; Chemotherapy; Drugs; Hepatotoxicity; Liver