title: Neutrality of miniSTR D22S1045 marker by Ewing's sarcoma phenotype.
abstract: Neutrality investigations of markers with forensic use are important to see if a phenotypic trait is being expressed in relation to the alleles of the marker. MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the EWS gene (22q12.2), which leads to the development of Ewing's Sarcoma. Analyzing allele frequencies and linkage disequilibrium in Ewing's sarcoma patients and non-affected populations, we found that the marker mD22S1045 was neutral when related to Ewing's Sarcoma.
authors.affiliation: Laboratory of Molecular and Human Genetics, Faculty of Biosciences, PUCRS, 90619-900 Porto Alegre, RS, Brazil.
authors.forename: Deborah S B S
authors.initials: DS
authors.lastname: Silva
authors.forename: Paulo E
authors.initials: PE
authors.lastname: Raimann
authors.forename: Tatiane
authors.initials: T
authors.lastname: Moro
authors.forename: Juliane B
authors.initials: JB
authors.lastname: Picanço
authors.forename: Ana L
authors.initials: AL
authors.lastname: Abujamra
authors.forename: Caroline B
authors.initials: CB
authors.lastname: de Farias
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
authors.forename: Algemir L
authors.initials: AL
authors.lastname: Brunetto
authors.forename: Clarice S
authors.initials: CS
authors.lastname: Alho
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002904:Chromosomes, Human, 21-22 and Y / Q000235:genetics*; D016172:DNA Fingerprinting / Q000379:methods; D053803:Forensic Genetics / Q000379:methods*; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics; D010641:Phenotype; D012512:Sarcoma, Ewing / Q000235:genetics*
chemical_list: D005819:Genetic Markers
keywords: Chromosome 22; Ewing’s sarcoma; Forensic markers; MiniSTR; mD22S1045