title: MicroRNAs as novel immunotherapeutics.
abstract: A large unmet need exists for cost-effective, widely available antineoplastic immunotherapeutic agents with a robust translational potential. MicroRNAs (miRNAs) that regulate tumor-mediated immunosuppression or immune checkpoints can induce robust therapeutic immune responses, indicating that miRNAs may ultimately become part of the portfolio of anticancer immunotherapeutics.
authors.affiliation: Department of Neurosurgery; The University of Texas M.D. Anderson Cancer Center; Houston, TX USA.
authors.forename: Amy B
authors.initials: AB
authors.lastname: Heimberger
authors.forename: Mark
authors.initials: M
authors.lastname: Gilbert
authors.forename: Ganesh
authors.initials: G
authors.lastname: Rao
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
keywords: cancer stem cells; glioblastoma multiforme; immunosuppression; microRNAs; regulatory T cells; signal transducer and activator of transcription 3