title: Secondary osteoporosis: differential diagnosis and workup.
abstract: There are numerous causes of secondary osteoporosis including endocrine disorders, nutritional deficiencies, and other miscellaneous conditions and medications. It is essential to identify and address these factors to appropriately manage patients with osteoporosis. Failure to do so may result in further bone loss despite pharmacologic intervention for osteoporosis. The following diagnostic studies should be considered initially: complete blood count, complete metabolic panel, 25-hydroxyvitamin D level, testosterone level in men, and 24-hour urinary calcium, sodium, and creatinine. Further testing may be performed in selected patients depending on the clinical picture and results of the initial workup.
authors.affiliation: *Department of Internal Medicine, Division of Endocrinology/Metabolism, Cincinnati VA Medical Center, University of Cincinnati Bone Health and Osteoporosis Center; †Mercy Health Osteoporosis and Bone Health Services, Cincinnati, Ohio.
authors.forename: Dima L
authors.initials: DL
authors.lastname: Diab
authors.forename: Nelson B
authors.initials: NB
authors.lastname: Watts
mesh_terms: D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D053565:Hypercalciuria / Q000150:complications / Q000175:diagnosis; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000175:diagnosis; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis; D007006:Hypogonadism / Q000150:complications / Q000175:diagnosis; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology*; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis