title: Injectable biphasic calcium phosphate cements as a potential bone substitute.
abstract: Apatitic calcium phosphate cements (CPCs) have been widely used as bone grafts due to their excellent osteoconductive properties, but the degradation properties are insufficient to stimulate bone healing in large bone defects. A novel approach to overcome the lack of degradability of apatitic CPC involves the development of biphasic CPCs (BCPC) based on tricalcium phosphate (TCP) in both α- and β-polymorphs. The aim of the current study was to prepare and analyze the physicochemical properties of BCPCs based on dual phase α/β-TCP as obtained by heat treatment of pure α-TCP. The handling and mechanical characteristics of the samples as well as the degradation behavior under in vitro condition were investigated and compared with a standard monophasic α-TCP-based CPC. The results showed that different heat treatments of commercially available α-TCP allowed the formation of biphasic calcium phosphate powder with a variety of α/β-TCP ratios. The use of biphasic powder particles as a reactant for CPCs resulted into increased setting and injectability times of the final BCPCs. During hardening of the cements, the amount of apatite formation decreased with increasing β-TCP content in the biphasic precursor powders. The morphology of the monophasic CPC consisted of plate-like crystals, whereas needle-like crystals were observed for BCPCs. In vitro degradation tests demonstrated that dissolution rate and corresponding calcium release from the set cements increased considerably with increasing β-TCP content, suggesting that apatitic CPCs can be rendered degradable by using biphasic α/β-TCP as powder precursor phase.
authors.affiliation: Department of Biomaterials, Radboud University Nijmegen Medical Center, 6500 HB, Nijmegen, The Netherlands.
authors.forename: Kemal
authors.initials: K
authors.lastname: Sariibrahimoglu
authors.forename: Joop G C
authors.initials: JG
authors.lastname: Wolke
authors.forename: Sander C G
authors.initials: SC
authors.lastname: Leeuwenburgh
authors.forename: Li
authors.initials: L
authors.lastname: Yubao
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D001031:Apatites; D063566:Biodegradable Plastics; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D019245:Compressive Strength; D006882:Hydroxyapatites; D007267:Injections; D007536:Isomerism; D008855:Microscopy, Electron, Scanning; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D063566:Biodegradable Plastics; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C074950:hydroxyapatite-beta tricalcium phosphate; C018392:tricalcium phosphate
keywords: biphasic calcium phosphate; cement; degradation