title: Mean platelet volume is increased in patients with hypertensive crises.
abstract: Platelets may be activated in hypertension (HT). Hypertensive crisis is an extreme phenotype of HT and HT-related thrombotic complications. We aimed to assess mean platelet volume (MPV) in patients with hypertensive crises. This study included 215 hypertensive urgency (HU) patients (84 male, mean age = 66 ± 15 years) and 60 hypertensive emergency (HE) patients (26 male, mean age = 68 ± 13 years), who were admitted to the emergency department with a diagnosis of hypertensive crises. Control group was composed of age- and sex-matched 39 normotensive patients. Blood samples were withdrawn for whole blood count and routine biochemical tests. Systolic blood pressure (BP) was significantly higher in the HE group than in the HU group (p < 0.001). Median mean platelet volume (MPV) was higher in the HE group compared with HU and control groups [9.5 (Interquartile range, IQR: 8.7-10.1), 8.4 (IQR: 7.7-9.1), and 8.3 (IQR: 7.7-8.7) fl, each p < 0.001, respectively). In linear regression analysis, systolic BP (β = 0.18, 95% confidence intervals (CI): 0.002-0.015, p = 0.007) and diabetes mellitus (β = 0.24, 95% CI: 0.28-0.95, p < 0.001) were independently associated with MPV levels. Our findings show that MPV can be elevated in patients with HE and HU. It can be independently associated with systolic BP and diabetes mellitus. These findings imply that platelet activation contribute to the pathogenesis of thrombotic complications in hypertensive crises.
authors.affiliation: Department of Cardiology, Isparta State Hospital , Isparta , Turkey .
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Ahmet Kenan
authors.initials: AK
authors.lastname: Turkdogan
authors.forename: Mucahit
authors.initials: M
authors.lastname: Kapci
authors.forename: Ali
authors.initials: A
authors.lastname: Duman
authors.forename: Orhan
authors.initials: O
authors.lastname: Akpinar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D001792:Blood Platelets; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation
keywords: Hypertensive crises; mean platelet volume; target organ damage