title: Predicted cancer risks induced by computed tomography examinations during childhood, by a quantitative risk assessment approach.
abstract: The potential adverse effects associated with exposure to ionizing radiation from computed tomography (CT) in pediatrics must be characterized in relation to their expected clinical benefits. Additional epidemiological data are, however, still awaited for providing a lifelong overview of potential cancer risks. This paper gives predictions of potential lifetime risks of cancer incidence that would be induced by CT examinations during childhood in French routine practices in pediatrics. Organ doses were estimated from standard radiological protocols in 15 hospitals. Excess risks of leukemia, brain/central nervous system, breast and thyroid cancers were predicted from dose-response models estimated in the Japanese atomic bomb survivors' dataset and studies of medical exposures. Uncertainty in predictions was quantified using Monte Carlo simulations. This approach predicts that 100,000 skull/brain scans in 5-year-old children would result in eight (90 % uncertainty interval (UI) 1-55) brain/CNS cancers and four (90 % UI 1-14) cases of leukemia and that 100,000 chest scans would lead to 31 (90 % UI 9-101) thyroid cancers, 55 (90 % UI 20-158) breast cancers, and one (90 % UI <0.1-4) leukemia case (all in excess of risks without exposure). Compared to background risks, radiation-induced risks would be low for individuals throughout life, but relative risks would be highest in the first decades of life. Heterogeneity in the radiological protocols across the hospitals implies that 5-10 % of CT examinations would be related to risks 1.4-3.6 times higher than those for the median doses. Overall excess relative risks in exposed populations would be 1-10 % depending on the site of cancer and the duration of follow-up. The results emphasize the potential risks of cancer specifically from standard CT examinations in pediatrics and underline the necessity of optimization of radiological protocols.
authors.affiliation: Laboratory of Epidemiology, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France.
authors.forename: Neige
authors.initials: N
authors.lastname: Journy
authors.forename: Sophie
authors.initials: S
authors.lastname: Ancelet
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Rehel
authors.forename: Myriam
authors.initials: M
authors.lastname: Mezzarobba
authors.forename: Bernard
authors.initials: B
authors.lastname: Aubert
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurier
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Bernier
mesh_terms: D000328:Adult; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology*; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000009:adverse effects*; D035501:Uncertainty