title: Real-time in situ powder X-ray diffraction monitoring of mechanochemical synthesis of pharmaceutical cocrystals.
abstract: Looking in: The penetrating power of high-energy X-rays provides a means to monitor in situ and in real time the course of ball-milling reactions of organic pharmaceutical solids by detecting crystalline phases and assessing the evolution of their particle sizes. Upon switching from neat grinding to liquid-assisted grinding, cocrystal formation is enabled or tremendously accelerated, while the reaction mechanism alters its course.
authors.affiliation: Ruđer Bošković Institute, Zagreb (Croatia).
authors.forename: Ivan
authors.initials: I
authors.lastname: Halasz
authors.forename: Andreas
authors.initials: A
authors.lastname: Puškarić
authors.forename: Simon A J
authors.initials: SA
authors.lastname: Kimber
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Beldon
authors.forename: Ana M
authors.initials: AM
authors.lastname: Belenguer
authors.forename: Frank
authors.initials: F
authors.lastname: Adams
authors.forename: Veijo
authors.initials: V
authors.lastname: Honkimäki
authors.forename: Robert E
authors.initials: RE
authors.lastname: Dinnebier
authors.forename: Bhavnita
authors.initials: B
authors.lastname: Patel
authors.forename: William
authors.initials: W
authors.lastname: Jones
authors.forename: Vjekoslav
authors.initials: V
authors.lastname: Strukil
authors.forename: Tomislav
authors.initials: T
authors.lastname: Friščić
keywords: X-ray diffraction; cocrystals; mechanochemistry; pharmaceutical materials; reaction monitoring