title: Antimicrobial peptides from marine proteobacteria.
abstract: After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the efficiency of "classical" antibiotics has decreased significantly. New drugs to fight MDR strains are urgently needed. Bacteria hold much promise as a source of unusual bioactive metabolites. However, the potential of marine bacteria, except for Actinomycetes and Cyanobacteria, has been largely underexplored. In the past two decades, the structures of several antimicrobial compounds have been elucidated in marine Proteobacteria. Of these compounds, polyketides (PKs), synthesised by condensation of malonyl-coenzyme A and/or acetyl-coenzyme A, and non-ribosomal peptides (NRPs), obtained through the linkage of (unusual) amino acids, have recently generated particular interest. NRPs are good examples of naturally modified peptides. Here, we review and compile the data on the antimicrobial peptides isolated from marine Proteobacteria, especially NRPs.
authors.affiliation: University of Brest, LUBEM EA 3882, SFR 148, Quimper 29000, France. florie.desriac@univ-brest.fr.
authors.forename: Florie
authors.initials: F
authors.lastname: Desriac
authors.forename: Camille
authors.initials: C
authors.lastname: Jégou
authors.forename: Eric
authors.initials: E
authors.lastname: Balnois
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brillet
authors.forename: Patrick
authors.initials: P
authors.lastname: Le Chevalier
authors.forename: Yannick
authors.initials: Y
authors.lastname: Fleury
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D020560:Proteobacteria / Q000737:chemistry* / Q000378:metabolism*; D012623:Seawater / Q000382:microbiology*; D014871:Water Microbiology
chemical_list: D000890:Anti-Infective Agents; D010455:Peptides