title: Manufacture and characteristics of asymmetric membrane capsule shells with a novel wet phase inversion method.
abstract: In order to overcome the difficulty in stripping and to improve the automaticity and efficiency, a novel method was developed to prepare asymmetric membrane capsule shells (AM-CSs). Soluble mold pins were used to replace conventional insoluble mold pins, and simplified process was designed. Investigated by scanning electron microscopy and dye test, the homemade AM-CSs had typical asymmetric structure, in situ pore formation ability and high water influx. The in vitro dissolution properties of AM-CSs and homogeneous membrane capsule shells (HM-CSs) were compared. The release behavior of Metoprolol Tartrate and Nimodipine from the AM-CSs was mainly dominated by osmosis, while no drug could release from HM-CSs. The novel wet phase inversion method had significant advantages as well as potential value to be used in pharmaceutical research and application.
authors.affiliation: School of Pharmacy, Zhejiang University of Technology , Hangzhou , China and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ye-min
authors.initials: YM
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Wei-san
authors.initials: WS
authors.lastname: Pan
mesh_terms: D002214:Capsules / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D012995:Solubility; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002214:Capsules; D014867:Water
keywords: Asymmetric membrane capsule shells; metoprolol tartrate; nimodipine; osmotic drug delivery system; soluble mold pins