title: Association of inflammatory factors with occurrence and recurrence of atrial fibrillation: a meta-analysis.
abstract: BACKGROUND
  The role of circulating inflammatory factors in atrial fibrillation (AF) occurrence and recurrence remains inconclusive.
  
  
  METHODS
  We conducted a meta-analysis of observational studies evaluating the association of inflammatory factors with AF risk, postoperative AF (POAF) occurrence after coronary artery bypass grafting (CABG) surgery, and AF recurrence after electrical cardioversion (EC) or catheter ablation.
  
  
  RESULTS
  Increased C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α were significantly associated with AF risk (standardized mean difference [SMD] [95% confidence interval (CI)]: 0.95 [0.72-1.18], 0.89 [0.64-1.15] and 2.20 [1.17-3.23], respectively). In subgroup analysis, CRP was significantly associated with persistent and permanent AF risk, but not with paroxysmal AF. Increased preoperative CRP and IL-6 were associated with greater risk of post-CABG AF (SMD [95% CI]: 0.28 [0.02-0.54] and 1.03 [0.03-2.04], respectively). Consistent significant associations between CRP and AF recurrence were found in both patient subgroups who underwent EC (SMD, 0.56; 95% CI, 0.36-0.76) and ablation (SMD, 0.48; 95% CI, 0.11-0.86). IL-6 was significantly associated with AF recurrence after ablation (SMD, 0.55; 95% CI, 0.25-0.85), but not with the recurrence after EC (SMD, 0.85; 95% CI, -0.26-1.95).
  
  
  CONCLUSIONS
  Increased circulating inflammatory factors, such as CRP and IL-6, are associated with greater AF risk in general population and patients who underwent CABG, as well as with AF recurrence after EC or ablation. Future research is warranted to elucidate the roles of other inflammatory markers, such as white blood cell, IL-8, and transforming growth factor-β1, in occurrence and recurrence of well-established different clinical subtypes of AF.
authors.affiliation: Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiang
authors.forename: Long
authors.initials: L
authors.lastname: Wu
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Ma
authors.forename: Shifei
authors.initials: S
authors.lastname: Tong
authors.forename: Maoqing
authors.initials: M
authors.lastname: Shu
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Song
authors.forename: Yafei
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood / Q000453:epidemiology* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D064887:Observational Studies as Topic / Q000379:methods; D012008:Recurrence; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: Atrial fibrillation; Catheter ablation; Coronary artery bypass grafting surgery; Electrical cardioversion; Inflammatory factor; Meta-analysis