title: Fiber intake and risk of nasopharyngeal carcinoma: a case-control study.
abstract: Some studies examined the inverse relation between nasopharyngeal carcinoma (NPC) risk and dietary fibers in endemic populations. By means of a hospital-based case-control study, we verified whether this association was also present in Italy in connection with various types of dietary fibers. Cases were 198 patients with incident, histologically confirmed, NPC admitted to major teaching and general hospitals during 1992-2008. Controls were 594 patients admitted for acute, nonneoplastic conditions to the same hospital network of cases. Information was elicited using a validated food frequency questionnaire including 78 foods, food groups, or dishes. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated for quartiles of intake of different types of fiber after allowance for energy intake and other potential confounding factors. Total fiber intake was inversely related to risk of NPC (OR = 0.58 for the highest vs. the lowest quartile of intake; 95% CI: 0.34-0.96). We found an inverse association for total soluble (OR = 0.58; 95% CI: 0.35-0.96) and total insoluble fiber (OR = 0.56; 95% CI: 0.33-0.95), in particular cellulose (OR = 0.57; 95% CI: 0.33-0.96), and lignin (OR = 0.51; 95% CI: 0.31-0.85). In conclusion, this study suggests that dietary intake of soluble and insoluble fibers is inversely related to NPC risk in a nonendemic southern population.
authors.affiliation: a Unit of Epidemiology and Biostatistics , Centro di Riferimento Oncologico , IRCCS , Aviano , Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Bidoli
authors.forename: Claudio
authors.initials: C
authors.lastname: Pelucchi
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Luigi
authors.initials: L
authors.lastname: Barzan
authors.forename: Giovanni
authors.initials: G
authors.lastname: Franchin
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Paolo
authors.initials: P
authors.lastname: De Paoli
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma; D016022:Case-Control Studies; D016001:Confidence Intervals; D004043:Dietary Fiber / Q000008:administration & dosage*; D002523:Edible Grain; D002149:Energy Intake; D005247:Feeding Behavior; D005638:Fruit; D006801:Humans; D007558:Italy; D016015:Logistic Models; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000517:prevention & control*; D015596:Nutrition Assessment; D016017:Odds Ratio; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014675:Vegetables; D044465:White People; D055815:Young Adult
chemical_list: D004043:Dietary Fiber