title: Update in treatment and targets in Ewing sarcoma.
abstract: The improvement in outcome for patients with localized and metastatic Ewing sarcoma since the development of cytotoxic chemotherapy remains one of the most profound advances in oncology and one of the proudest achievements of sarcoma researchers. Identification of molecular targets for new treatments has become an intense area within Ewing sarcoma research. The development of improved preclinical Ewing sarcoma models and advanced molecular techniques will build on knowledge of EWS/FLI1 function, EWS/FLI1 transcription targets, and the other critical driver events in these tumors.
authors.affiliation: Division of Hematology Oncology, Yawkey Center for Outpatient Care, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Cote
authors.forename: Edwin
authors.initials: E
authors.lastname: Choy
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
keywords: Chemotherapy; Ewing sarcoma; Oncology; Treatment; Tumor