title: [Vasomotor endothelial dysfunction in young men with grade 1 arterial hypertension].
abstract: In order to study vasomotor endothelial function and risk factors of endothelial dysfunction in young men with grade 1 arterial hypertension (G1AH) we examined 76 men with G1AH and 30 healthy men aged 20-40 years. Flow-mediated vasodilatation (FMD) of the brachial artery was assessed by ultrasonic method of Celermajer D.S. Vasomotor endothelial dysfunction (FMD<6%) was found significantly more frequently in men with G1AH than in healthy men (51% vs 13%). In healthy young men with normal blood pressure smoking was the main risk factor of endothelial dysfunction. In young men with G1AH risk factors for endothelial dysfunction were: family history of early cardiovascular disease, smoking, and elevation of low-density cholesterol level. Probability of endothelial dysfunction in the absence of these factors was low - 11%, in the presence of one factor it was 30%, two factors - 60%, and three factors - 83%. Elevated (>14.8%) red blood cell distribution width (RDW) was associated with endothelial dysfunction. Probability of endothelial dysfunction in young men with G1AH and elevated RDW was 5 times greater than in those with normal RDW.
authors.affiliation: Institute of Cardiology, Russian Cardiology Scientific and Production Center, Tretiya Cherepkovskaya str.,15a, 121552 Moscow, Russia.
authors.forename: A R
authors.initials: AR
authors.lastname: Zairova
authors.forename: E V
authors.initials: EV
authors.lastname: Oshchepkova
authors.forename: A N
authors.initials: AN
authors.lastname: Rogoza
mesh_terms: D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004909:Erythrocyte Indices; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D014463:Ultrasonography; D014664:Vasodilation
chemical_list: D008077:Lipoproteins, LDL