title: 25th anniversary article: interfacing nanoparticles and biology: new strategies for biomedicine.
abstract: The exterior surface of nanoparticles (NPs) dictates the behavior of these systems with the outside world. Understanding the interactions of the NP surface functionality with biosystems enables the design and fabrication of effective platforms for therapeutics, diagnostics, and imaging agents. In this review, we highlight the role of chemistry in the engineering of nanomaterials, focusing on the fundamental role played by surface chemistry in controlling the interaction of NPs with proteins and cells.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, 01003, USA.
authors.forename: Gulen Yesilbag
authors.initials: GY
authors.lastname: Tonga
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Saha
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D000818:Animals; D000846:Anniversaries and Special Events; D002477:Cells / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D011506:Proteins
keywords: bionanotechnology; nano-bio interface; nanoparticles; stimuli responsive nanoparticles; surface functionality