title: Classification of schizophrenia using Genetic Algorithm-Support Vector Machine (GA-SVM).
abstract: Recently, Event-Related Potential (ERP) has being the most popular method in evaluating brain waves of schizophrenia patients. ERP is one of the electroencephalography (EEG), which is measured the change of brain waves after giving patients certain stimulations instead of resting state. However, with traditional statistical analysis method, both P50 and MMN showed significant difference between controls and patients but not in Gamma band. Gamma band is a 30-50 Hz auditory stimulation which had been suggested may be abnormal in schizophrenia patients. Our data are recruited from 5 schizophrenia patients and 5 controls in National Taiwan University Hospital have been tested with this platform. The results showed that detection rate is 88.24% and we also analyzed the importance of features, including Standard Deviation (SD) and Total Variation (TotalVar) in different stage of wavelet transform. Therefore, this proposed methodology could serve as a valuable clinical decision support for physiologists in evaluating schizophrenia.
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Hiesh
authors.forename: Yan-Yu
authors.initials: YY
authors.lastname: Lam Andy
authors.forename: Chia-Ping
authors.initials: CP
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Feng-Shen
authors.initials: FS
authors.lastname: Lin
authors.forename: Hsiao-Ya
authors.initials: HY
authors.lastname: Sung
authors.forename: Jeng-Wei
authors.initials: JW
authors.lastname: Lin
authors.forename: Ming-Jang
authors.initials: MJ
authors.lastname: Chiu
authors.forename: Feipei
authors.initials: F
authors.lastname: Lai
mesh_terms: D000161:Acoustic Stimulation; D000465:Algorithms; D058256:Brain Waves; D016022:Case-Control Studies; D003198:Computer Simulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D060388:Support Vector Machine; D013624:Taiwan; D058067:Wavelet Analysis