title: Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging.
abstract: We present the results of a feasibility study with spatial frequency domain imaging (SFDI) to produce quantitative measurements of optical property and chromophore concentration maps of three porcine kidneys utilizing a renal occlusion model at the near-infrared wavelengths of 658, 730, and 850 nm. Using SFDI, we examined the dynamics of absolute oxygen saturation (StO2). The mean StO2 for the kidneys varied from approximately 60% before occlusion, to 20% during occlusion, to 55% after reperfusion. We also present, for the first time to the best of our knowledge, reduced scattering coefficient (μ(s)') maps of the kidney during occlusion. We observed a substantial decrease in the wavelength dependence of scattering (i.e., scattering power) in the three kidneys, with a mean decrease of 18%±2.6%, which is indicative of an increase in scatterer size, and is likely due to tissue changes such as edema that follow from occlusion and inflammation.
authors.forename: K P
authors.initials: KP
authors.lastname: Nadeau
authors.forename: A
authors.initials: A
authors.lastname: Ponticorvo
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: A J
authors.initials: AJ
authors.lastname: Durkin
authors.forename: B J
authors.initials: BJ
authors.lastname: Tromberg
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000378:metabolism*; D003952:Diagnostic Imaging / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D061848:Optical Imaging / Q000379:methods*; D055620:Optical Phenomena; D010100:Oxygen / Q000378:metabolism; D013552:Swine
chemical_list: D010100:Oxygen