title: Developmental change of amplitude-integrated electroencephalographic activity in preterm infants with intraventricular hemorrhage.
abstract: BACKGROUND
  Amplitude-integrated electroencephalography (aEEG) allows continuous brain function monitoring at bedside.
  
  
  OBJECTIVE
  This prospective cohort study was designed to longitudinally evaluate aEEG tracings at increased postmenstrual age (PMA) in preterm infants with intraventricular hemorrhage (IVH).
  
  
  METHODS
  Biweekly aEEG recordings were performed on preterm infants <32 weeks gestational age from 24 to 36 weeks PMA. The tracings were evaluated according to a scoring system adapted from Burdjalov et al.
  
  
  RESULTS
  We analyzed 496 aEEG recordings in 105 preterm infants. The control group consisted of 42 infants with no IVH, whereas the IVH grade I, II, III, and IV groups consisted of 38, 8, 3, and 14 infants, respectively. There were significant differences in the cycling and total maturation scores among the IVH groups at 36 weeks PMA (p = 0.010 and p = 0.006, respectively). The IVH-IV patients maintained low scores in their cycling as their PMA increased, in contrast to their continuity and amplitude scores. The risk factors affecting the aEEG maturation scores at 36 weeks PMA in the IVH-IV patients included seizure events with the administration of antiepileptic drugs and the insertion of external ventricular drains (β = -0.679 and β = -0.418, respectively; p = 0.003).
  
  
  CONCLUSIONS
  The low cycling scores persisted until 36 weeks PMA in the IVH-IV group.
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jin A
authors.initials: JA
authors.lastname: Sohn
authors.forename: Han-Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lee
authors.forename: Juyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Jin A
authors.initials: JA
authors.lastname: Lee
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Choi
authors.forename: Ee-Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Beyong Il
authors.initials: BI
authors.lastname: Kim
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000704:Analysis of Variance; D001921:Brain / Q000254:growth & development*; D015331:Cohort Studies; D004569:Electroencephalography / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D020300:Intracranial Hemorrhages / Q000503:physiopathology*; D008137:Longitudinal Studies; D011446:Prospective Studies; D056910:Republic of Korea; D018709:Statistics, Nonparametric
keywords: Amplitude-integrated electroencephalography; Intraventricular hemorrhage; Maturation score; Preterm infant