title: Significance of caveolin-1 regulators in pancreatic cancer.
abstract: Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.
authors.affiliation: Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, Shanghai, China E-mail : yuxianjun88@hotmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Hua-Xiang
authors.initials: HX
authors.lastname: Xu
authors.forename: Wen-Quan
authors.initials: WQ
authors.lastname: Wang
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Wu
authors.forename: Wan-Tong
authors.initials: WT
authors.lastname: Yao
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Yu
mesh_terms: D000818:Animals; D051242:Caveolin 1 / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*
chemical_list: D051242:Caveolin 1