title: An in vitro demonstration of CMOS-based optoelectronic neural interface device for optogenetics.
abstract: A CMOS-based neural interface device equipped with an integrated micro light source array for optogenetics was fabricated and demonstrated. A GaInN LED array formed on sapphire substrate was successfully assembled with a multifunctional CMOS image sensor that is capable of on-chip current injection. We demonstrated a functionality of light stimulation onto ChR2-expressed cells in an in vitro experiment. A ChR2-expressed cell were successfully stimulated with the light emitted from the fabricated device.
authors.forename: T
authors.initials: T
authors.lastname: Tokuda
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Maezawa
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: K
authors.initials: K
authors.lastname: Sasagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: S
authors.initials: S
authors.lastname: Shiosaka
authors.forename: J
authors.initials: J
authors.lastname: Ohta
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D000075402:Channelrhodopsins; D004581:Electronics / Q000295:instrumentation*; D004867:Equipment Design; D015640:Ion Channel Gating / Q000528:radiation effects; D008027:Light; D008670:Metals / Q000737:chemistry*; D051379:Mice; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects; D062308:Optogenetics / Q000295:instrumentation*; D010087:Oxides / Q000737:chemistry*; D012666:Semiconductors
chemical_list: D000075402:Channelrhodopsins; D008670:Metals; D010087:Oxides