title: In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complex.
abstract: The in vitro activity of cefoxitin and imipenem was compared for 43 strains of the Mycobacterium abscessus complex, mostly isolated from cystic fibrosis patients. The MICs of imipenem were lower than those of cefoxitin, although the number of imipenem-resistant strains was higher according to the CLSI breakpoints. Strain comparisons indicated that the MICs of cefoxitin were significantly higher for Mycobacterium bolletii than for M. abscessus. The MICs of both β-lactams were higher for the rough morphotype than for the smooth morphotype. The clinical impact of the in vitro difference between the activity of imipenem and that of cefoxitin remains to be determined.
authors.affiliation: INSERM, U872, LRMA, Equipe 12 du Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie, UMR S 872, Paris, France; Université Paris Descartes, UMR S 872, Paris, France; Service de Microbiologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lavollay
authors.forename: V
authors.initials: V
authors.lastname: Dubée
authors.forename: B
authors.initials: B
authors.lastname: Heym
authors.forename: J-L
authors.initials: JL
authors.lastname: Herrmann
authors.forename: J-L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: L
authors.initials: L
authors.lastname: Gutmann
authors.forename: M
authors.initials: M
authors.lastname: Arthur
authors.forename: J-L
authors.initials: JL
authors.lastname: Mainardi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D012141:Respiratory Tract Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002440:Cefoxitin; D015378:Imipenem
keywords: Antimicrobial susceptibility; Mycobacterium abscessus; cefoxitin; cystic fibrosis; imipenem