title: Materials and manufacturing technologies available for production of a pediatric bioabsorbable stent.
abstract: Transcatheter treatment of children with congenital heart disease such as coarctation of the aorta and pulmonary artery stenosis currently involves the use of metal stents. While these provide good short term results, there are long term complications with their use. Children outgrow metal stents, obligating them to future transcatheter dilations and eventual surgical removal. A bioabsorbable stent, or a stent that goes away with time, would solve this problem. Bioabsorbable stents are being developed for use in coronary arteries, however these are too small for use in pediatric congenital heart disease. A bioabsorbable stent for use in pediatric congenital heart disease needs to be low profile, expandable to a diameter 8 mm, provide sufficient radial strength, and absorb quickly enough to allow vessel growth. Development of absorbable coronary stents has led to a great understanding of the available production techniques and materials such as bioabsorbable polymers and biocorrodable metals. Children with congenital heart disease will hopefully soon benefit from the current generation of bioabsorbable and biocorrodable materials and devices.
authors.affiliation: Mattel Children's Hospital, University of California, Los Angeles, CA 90095, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Alexy
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Levi
mesh_terms: D020341:Absorbable Implants; D002648:Child; D003330:Coronary Vessel Anomalies / Q000473:pathology / Q000628:therapy; D003331:Coronary Vessels / Q000254:growth & development / Q000473:pathology; D003343:Corrosion; D006330:Heart Defects, Congenital / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008670:Metals / Q000737:chemistry / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D015607:Stents
chemical_list: D008670:Metals; D011108:Polymers