title: Cholesterol: fa(s)t-food for enterovirus genome replication.
abstract: Hijacking and remodeling of host membranes is an obligatory step in the replicative cycle of (+)RNA viruses, including enteroviruses. Ilnytska et al. unveiled in Cell Host & Microbe that enteroviruses usurp clathrin-mediated endocytosis to shuttle cholesterol to sites of genome replication and that cholesterol is needed for efficient replication.
authors.affiliation: Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.
authors.forename: Jeroen R P
authors.initials: JR
authors.lastname: Strating
authors.forename: Hilde M
authors.initials: HM
authors.lastname: van der Schaar
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: van Kuppeveld
mesh_terms: D002784:Cholesterol / Q000378:metabolism*; D004705:Endocytosis; D004770:Enterovirus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014779:Virus Replication
chemical_list: D002784:Cholesterol