title: [Endocrinological outcome in children and adolescents survivors of central nervous system tumours after a 5 year follow-up].
abstract: BACKGROUND
  Given the successful increase in survival rates with the current treatments for central nervous system tumours (CNST), survivors are at high risk for late adverse effects.
  
  
  OBJECTIVE
  To evaluate the endocrine sequelae in children with CNST according to the type of tumour and treatment received.
  
  
  METHODS
  A retrospective review of the clinical features, auxology, hormone determinations and imaging findings of 38 patients (36.8% females, 63.2% males) with CNST, with a minimum of 5 years follow-up, was performed.
  
  
  RESULTS
  The mean age at diagnosis was 5.34 ± 3.07 years, with 76.3% of the patients having at least one hormone deficiency, of which growth hormone (GH) (73.7% of all patients) was the most prevalent, followed by thyrotropin (TSH) (68.4%), corticotropin (31.6%), antidiuretic hormone (28.9%), and gonadotropin (LH/FSH) (21.1%) deficiency. Precocious puberty was found in 21.1% of patients. After 5 years of follow-up, 28.9% were obese. Craniopharyngioma had more hormone deficiencies, obesity and recurrence rates. The most frequently administered treatment was surgery + chemotherapy + radiotherapy, in 47.4% of the patients. Mean final height (20 patients) was -1.2 1.6 SDS, with a mean difference of -0.53 SDS regarding their target height.
  
  
  CONCLUSIONS
  1) The type of tumour and treatment received influence the endocrinological sequelae. 2) The most frequent hormone deficiencies in all types of CNST, regardless of the treatment received, were GH and TSH. 3) Early diagnosis and prompt intervention of endocrine dysfunction can reduce the morbidity and improve quality of life over the long term.
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Güemes Hidalgo
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España; Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España; Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, España; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, España. Electronic address: maitemunozcalvo@gmail.com.
authors.forename: M T
authors.initials: MT
authors.lastname: Muñoz Calvo
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España.
authors.forename: L
authors.initials: L
authors.lastname: Fuente Blanco
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Villalba Castaño
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España; Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España; Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, España; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, España.
authors.forename: G A
authors.initials: GA
authors.lastname: Martos Moreno
authors.affiliation: Servicio de Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España; Servicio de Pediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España; Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, España; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Argente
mesh_terms: D000293:Adolescent; D016543:Central Nervous System Neoplasms / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004700:Endocrine System Diseases / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D017741:Survivors; D013997:Time Factors
keywords: Cancer survivors; Childhood brain tumours; Eje hipotálamo-hipofisario; Endocrine late effects; Hypothalamic pituitary axis; Secuelas endocrinas; Supervivientes de cáncer; Tumores cerebrales infantiles