title: Transcriptional regulation by hypoxia inducible factors.
abstract: The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
authors.affiliation: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO 80309-0347, U.S.A.
authors.forename: Veronica L
authors.initials: VL
authors.lastname: Dengler
authors.affiliation: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO 80309-0347, U.S.A.
authors.forename: Matthew
authors.initials: M
authors.lastname: Galbraith
authors.affiliation: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO 80309-0347, U.S.A.
authors.forename: Joaquín M
authors.initials: JM
authors.lastname: Espinosa
mesh_terms: D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism*; D051793:Hypoxia-Inducible Factor 1 / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012319:RNA Polymerase II / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D051793:Hypoxia-Inducible Factor 1; D012319:RNA Polymerase II