title: Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration.
abstract: BACKGROUND
  Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood.
  
  
  RESULTS
  Using linear mixed effects models, we investigated the relationship between CSF levels of heart fatty acid binding protein (HFABP), a lipid binding protein involved with fatty acid metabolism and lipid transport, amyloid-β (Aβ), phospho-tau, and longitudinal MRI-based measures of brain atrophy among 295 non-demented and demented older individuals. Across all participants, we found a significant association of CSF HFABP with longitudinal atrophy of the entorhinal cortex and other AD-vulnerable neuroanatomic regions. However, we found that the relationship between CSF HABP and brain atrophy was significant only among those with low CSF Aβ1-42 and occurred irrespective of phospho-tau181p status.
  
  
  CONCLUSIONS
  Our findings indicate that Aβ-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau. This implicates a potentially important role for fatty acid binding proteins in Alzheimer's disease neurodegeneration.
authors.affiliation: Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037-0841, USA. rdesikan@ucsd.edu.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Desikan
authors.forename: Wesley K
authors.initials: WK
authors.lastname: Thompson
authors.forename: Dominic
authors.initials: D
authors.lastname: Holland
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Hess
authors.forename: James B
authors.initials: JB
authors.lastname: Brewer
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Linda K
authors.initials: LK
authors.lastname: McEvoy
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: Anders M
authors.initials: AM
authors.lastname: Dale
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000134:cerebrospinal fluid*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D016875:tau Proteins