title: FDG PET/CT and enhanced CT imaging of tumor heterogeneity in hepatocellular carcinoma: imaging-pathologic correlation.
abstract: Tumor heterogeneity is used to define the appearance of different histological differentiation within a single neoplasm. We present a case of single hepatocellular carcinoma showing both low and high FDG uptake areas. The low FDG uptake area was corresponding to low-grade HCC, and the high FDG uptake area was corresponding to high-grade HCC. This case indicates that the tumor grades affect intratumoral heterogeneity in FDG distribution. FDG PET/CT can be useful for guiding tissue sampling of the HCC with heterogeneous histological differentiations, and obviating overestimation or underestimation of the proportion of the higher-risk cell population.
authors.affiliation: From the *Department of Nuclear Medicine, Changhai Hospital, †Department of Pathology, Eastern Hepatobiliary Surgery Hospital, and ‡Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Aisheng
authors.initials: A
authors.lastname: Dong
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.forename: Changjing
authors.initials: C
authors.lastname: Zuo
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18