title: Immune reconstitution inflammatory syndrome mimics a relapse of AIDS-related Burkitt lymphoma.
abstract: Immune reconstitution inflammatory syndrome (IRIS) is associated with clinical manifestations that can overlap with the patients with acquired immunodeficiency disease (AIDS)-related non-Hodgkin's lymphoma. We herein report a case of AIDS-related Burkitt lymphoma which was successfully treated with dose-adjusted etoposide, doxorubicin, cyclophosphamide, vincristine, and prednisone (EPOCH). However, the patient developed a lymphoma-like clinical presentation shortly after the conclusion of chemotherapy. The patient's symptoms were identical to the initial symptoms characteristic of lymphoma; however, the laboratory data revealed no evidence of a relapse of Burkitt lymphoma. A bone marrow examination showed T-cell clonality, even though there were no signs of any progression of the lymphoma. The patient was diagnosed with IRIS, and the clinical manifestations rapidly improved following treatment.
authors.affiliation: Kitano Hospital, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Fukunaga
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Shojiro
authors.initials: S
authors.lastname: Inano
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sueki
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Yoshinaga
authors.forename: Soshi
authors.initials: S
authors.lastname: Yanagida
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Arima
mesh_terms: D000328:Adult; D002051:Burkitt Lymphoma / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications / Q000175:diagnosis*; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000175:diagnosis*; D008297:Male