title: Temporal resolution of nanopore sensor recordings.
abstract: Here we discuss the limits to temporal resolution in nanopore sensor recordings, which arise from considerations of both small-signal frequency response and accumulated noise power. Nanopore sensors have strong similarities to patch-clamp ion channel recordings, except that the magnitudes of many physical parameters are substantially different. We will present examples from our recent work developing high-speed nanopore sensing platforms, in which we physically integrated nanopores with custom low-noise complementary metal-oxide-semiconductor (CMOS) circuitry. Close physical proximity of the sensor and amplifier electronics can reduce parasitic capacitances, improving both the signal-to-noise ratio and the effective temporal resolution of the recordings.
authors.forename: Jacob K
authors.initials: JK
authors.lastname: Rosenstein
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Shepard
mesh_terms: D000669:Amplifiers, Electronic; D004560:Electricity; D004581:Electronics; D058608:Nanopores; D036103:Nanotechnology / Q000295:instrumentation*; D059629:Signal-To-Noise Ratio; D013997:Time Factors