title: Enhanced biocorrosion resistance and biocompatibility of degradable Mg-Nd-Zn-Zr alloy by brushite coating.
abstract: To further improve the corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy (JDBM), a biodegradable calcium phosphate coating (Ca-P coating) with high bonding strength was developed using a novel chemical deposition method. The main composition of the Ca-P coating was brushite (CaHPO4·2H2O). The bonding strength between the coating and the JDBM substrate was measured to be over 10 MPa, and the thickness of the coating layer was about 10-30 μm. The in vitro corrosion tests indicated that the Ca-P treatment improved the corrosion resistance of JDBM alloy in Hank's solution. Ca-P treatment significantly reduced the hemolysis rate of JDBM alloy from 48% to 0.68%, and induced no toxicity to MC3T3-E1 cells. The in vivo implantation experiment in New Zealand's rabbit tibia showed that the degradation rate was reduced obviously by the Ca-P treatment and less gas was produced from Ca-P treated JDBM bone plates and screws in early stage of the implantation, and at least 10weeks degradation time can be prolonged by the present coating techniques. Both Ca-P treated and untreated JDBM Mg alloy induced bone growth. The primary results indicate that the present Ca-P treatment is a promising technique for the degradable Mg-based biomaterials for orthopedic applications.
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Niu
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.forename: Yi
authors.initials: Y
authors.lastname: Liao
authors.forename: Lin
authors.initials: L
authors.lastname: Mao
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yongping
authors.initials: Y
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yaohua
authors.initials: Y
authors.lastname: He
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Ding
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000633:toxicity; D003343:Corrosion; D005740:Gases / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D011312:Pressure; D011817:Rabbits; D013977:Tibia / Q000473:pathology
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005740:Gases; C571250:Mg-Nd-Zn-Zr alloy; C494366:calcium phosphate, dibasic, dihydrate
keywords: Biodegradation; Brushite coating; Cytotoxicity; Hemolysis; Mg–Nd–Zn–Zr alloy