title: Effete, an E2 ubiquitin-conjugating enzyme with multiple roles in Drosophila development and chromatin organization.
abstract: The Drosophila effete gene encodes an extremely conserved class I E2 ubiquitin-conjugating enzyme. Growing evidence indicates that Eff is involved in many cellular processes including eye development, maintenance of female germline stem cells, and regulation of apoptosis. Eff is also a major component of Drosophila chromatin and it is particularly enriched in chromatin with repressive properties. In addition, Eff is required for telomere protection and to prevent telomere fusion. Consistent with its multiple roles in chromatin maintenance, Eff is also one of the rare factors that modulate both telomere-induced and heterochromatin-induced position effect variegation.
authors.affiliation: Dipartimento di Biologia e Biotecnologie "C. Darwin"; SAPIENZA Università di Roma; Roma, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cipressa
authors.affiliation: Dipartimento di Biologia e Biotecnologie "C. Darwin"; SAPIENZA Università di Roma; Roma, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cenci
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005260:Female; D008297:Male; D059505:Telomere Homeostasis / Q000235:genetics; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D044763:Ubiquitin-Conjugating Enzymes; C471611:eff protein, Drosophila
keywords: E2 enzyme; PEV; TPE; UbcD1; chromatin organization; effete