title: Do neuronal autoantibodies cause psychosis? A neuroimmunological perspective.
abstract: In the last decade, autoantibodies targeting proteins on the neuronal surface and that are believed to be directly pathogenic have been described in patients with autoimmune encephalitis. Since then, new antigenic targets have been discovered, and new clinical phenotypes have been recognized. The psychotic disorders are one example of this expanding spectrum. Here, we consider the defining criteria of antibody-mediated central nervous system disease and the extent to which the psychiatric data currently satisfy those criteria. We discuss the implications these findings have for our understanding, nosology, and treatment of psychiatric disorders.
authors.affiliation: Nuffield Department of Clinical Neurosciences and Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
authors.forename: Ester
authors.initials: E
authors.lastname: Coutinho
authors.affiliation: Nuffield Department of Clinical Neurosciences and Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Harrison
authors.affiliation: Nuffield Department of Clinical Neurosciences and Department of Psychiatry, University of Oxford, Oxford, United Kingdom. Electronic address: angela.vincent@ndcn.ox.ac.uk.
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D009474:Neurons / Q000276:immunology*; D011618:Psychotic Disorders / Q000276:immunology* / Q000628:therapy
chemical_list: D001323:Autoantibodies
keywords: Antibody-mediated disease; autoimmune encephalitis; psychosis; schizophrenia