title: One-pot, single-step deracemization of 2-hydroxyacids by tandem biocatalytic oxidation and reduction.
abstract: A facile and efficient one-pot, single-step method for deracemizing a broad range of 2-hydroxyacids to (R)-2-hydroxyacids was established by combination of resting cells of an (S)-hydroxyacid dehydrogenase-producing microorganism and an (R)-ketoacid reductase-producing microorganism.
authors.affiliation: Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China. zhengyg@zjut.edu.cn.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Xue
authors.forename: Yu-Guo
authors.initials: YG
authors.lastname: Zheng
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Jing-Lei
authors.initials: JL
authors.lastname: Sun
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Yin-Chu
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D055162:Biocatalysis; D006880:Hydroxy Acids / Q000737:chemistry*; D010084:Oxidation-Reduction; D011550:Pseudomonas aeruginosa / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D006880:Hydroxy Acids; D000429:Alcohol Oxidoreductases