title: Schistocytes, echinocytes, iron deficiency anemia, and thrombocytopenia - hematologic manifestations of splenic angiosarcoma.
abstract: Splenic angiosarcoma is a rare and aggressive malignancy with an incidence of less than one per million and a fatality rate over 90%.  Early diagnosis is of great importance for optimal management.  Here, we report the case of a patient with splenic angiosarcoma who presented with prominent schistocytes, echinocytes, thrombocytopenia, and iron deficiency anemia, which in combination with radiographic evidence of a splenic mass, raised the suspicion for angiosarcoma and resulted in a prompt surgical intervention with curative intent. Resolution of the hematologic findings following splenectomy suggests that patients with this malignancy should be monitored for recurrent hematologic abnormalities as they may herald recurrence of the disease. We present a literature review on the hematologic manifestations that is associated with this malignant disease.
authors.affiliation: University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, USA. aemadi@umm.edu.
authors.forename: Paula
authors.initials: P
authors.lastname: Rosenblatt
authors.forename: Rima
authors.initials: R
authors.lastname: Koka
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: John C
authors.initials: JC
authors.lastname: Papadimitriou
authors.forename: Edward A
authors.initials: EA
authors.lastname: Sausville
authors.forename: Ashkan
authors.initials: A
authors.lastname: Emadi
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D002675:Child, Preschool; D004912:Erythrocytes / Q000473:pathology*; D006394:Hemangiosarcoma / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D013160:Splenic Neoplasms / Q000097:blood / Q000150:complications*; D013921:Thrombocytopenia / Q000209:etiology*