title: Syntheses of precursors and reference compounds of the melanin-concentrating hormone receptor 1 (MCHR1) tracers [¹¹C]SNAP-7941 and [¹⁸F]FE@SNAP for positron emission tomography.
abstract: The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor's eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [(11)C]SNAP-7941 and [(18)F]FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.
authors.affiliation: University of Vienna, Department of Drug and Natural Product Synthesis, Althanstraße 14, 1090 Vienna, Austria. eva.schirmer@univie.ac.at.
authors.forename: Eva
authors.initials: E
authors.lastname: Schirmer
authors.forename: Karem
authors.initials: K
authors.lastname: Shanab
authors.forename: Barbara
authors.initials: B
authors.lastname: Datterl
authors.forename: Catharina
authors.initials: C
authors.lastname: Neudorfer
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.forename: Cécile
authors.initials: C
authors.lastname: Philippe
authors.forename: Helmut
authors.initials: H
authors.lastname: Spreitzer
mesh_terms: D000081:Acetamides / Q000737:chemistry; D003500:Cyclization; D006801:Humans; D010880:Piperidines / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography / Q000592:standards; D011743:Pyrimidines / Q000138:chemical synthesis*; D011744:Pyrimidinones / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; C103263:MCHR1 protein, human; D010880:Piperidines; D011743:Pyrimidines; D011744:Pyrimidinones; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C464854:SNAP7941