title: Influence of nanostructures on the biological properties of Ti implants after anodic oxidation.
abstract: Anodic oxidation was applied to produce nanostructures on the surface of titanium (Ti) implants. The bioactivity of the Ti implants was evaluated by simulated body fluid soaking test. The biocompatibility was investigated by in vitro cell culture test. The results showed that bone-like apatite was formed on the anodized Ti surface, but not on the as-polished Ti surface after immersion in simulated body fluid for 2 weeks. Cells cultured on the anodized Ti surface showed enhanced cell adhesion and proliferation, compared to those cultured on the as-polished Ti surface. Based on these results, it can be concluded that anodic oxidation improved the bioactivity and biocompatibility of Ti surface, which was attributed to the formation of nanostructures as well as the nanostructure induced high surface roughness and hydrophilicity.
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
authors.forename: Baoe
authors.initials: B
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Fu
authors.forename: Haipeng
authors.initials: H
authors.lastname: Li
authors.forename: Hongshui
authors.initials: H
authors.lastname: Wang
authors.forename: Shigang
authors.initials: S
authors.lastname: Xin
authors.forename: Linxi
authors.initials: L
authors.lastname: Zhou
authors.forename: Chunyong
authors.initials: C
authors.lastname: Liang
authors.forename: Changyi
authors.initials: C
authors.lastname: Li
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D051379:Mice; D058608:Nanopores / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016348:Osseointegration; D010084:Oxidation-Reduction; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D014025:Titanium; D005459:Fluorides; C032240:titanium tetrafluoride