title: miRNA in mycosis fungoides and skin inflammation.
abstract: In this mini-review, progress in our understanding of the link between miRNAs and cytokines in inflammatory skin diseases is highlighted with focus on miR-155 in mycosis fungoides (MF). MF is the most common variant of cutaneous T-cell lymphoma (CTCL) and is characterized by malignant T-cell proliferation in a chronic inflammatory environment in affected skin. Recent data show that miR-155 is expressed in situ by both malignant and non-malignant T cells, induced via the STAT5 signal pathway and IL-2Rbeta/gamma cytokines, and thus suggest the importance of miR-155 in malignant proliferation, clinical diagnosis, and prognosis in CTCL.
authors.affiliation: Division of Experimental Cancer Research, Department of Laboratory Medicine, Lund University, Clinical Research Center, Malmö, Sweden.
authors.forename: Jenny Liao
authors.initials: JL
authors.lastname: Persson
mesh_terms: D003872:Dermatitis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D019409:Interleukin-15 / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D009182:Mycosis Fungoides / Q000235:genetics* / Q000276:immunology; D050799:STAT5 Transcription Factor / Q000502:physiology; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology
chemical_list: D019409:Interleukin-15; D007376:Interleukin-2; C524942:MIRN155 microRNA, human; D035683:MicroRNAs; D050799:STAT5 Transcription Factor
keywords: MiR-155; STAT5 signal pathway; cytokines; skin inflammation