title: MiR-184 regulates insulin secretion through repression of Slc25a22.
abstract: Insulin secretion from pancreatic β-cells plays an essential role in blood glucose homeostasis and type 2 diabetes. Many genes are involved in the secretion of insulin and most of these genes can be targeted by microRNAs (miRNAs). However, the role of miRNAs in insulin secretion and type 2 diabetes has not been exhaustively studied. The expression miR-184, a miRNA enriched in pancreatic islets, negatively correlates with insulin secretion, suggesting that it is a good candidate for miRNA-mediated regulation of insulin secretion. Here we report that miR-184 inhibits insulin secretion in the MIN6 pancreatic β-cell line through the repression of its target Slc25a22, a mitochondrial glutamate carrier. Our study provides new insight into the regulation of insulin secretion by glutamate transport in mitochondria.
authors.affiliation: Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University , Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Morita
authors.forename: Takuro
authors.initials: T
authors.lastname: Horii
authors.forename: Mika
authors.initials: M
authors.lastname: Kimura
authors.forename: Izuho
authors.initials: I
authors.lastname: Hatada
keywords: Diabetes; Insulin; miRNA