title: Glucose intolerance states in women with the polycystic ovary syndrome.
abstract: The polycystic ovary syndrome (PCOS), the most common hyperandrogenic disorder affecting 4-7% of women, is often associated with metabolic alterations, chiefly insulin resistance and obesity. Based on available scientific evidence, PCOS should be regarded as an independent risk for the development of glucose intolerance states. This short review summarizes the available literature on the prevalence and incidence of impaired glucose tolerance and Type 2 diabetes in this disorder. In addition, some insights on potential factors responsible for individual susceptibility are discussed. Targeted intervention studies focused on prevention and treatment of glucose intolerance states in PCOS are warranted.
authors.affiliation: Division of Endocrinology, Department of Medical and Surgical Sciences (DIMEC), S. Orsola-Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, Bologna, Italy. renato.pasquali@unibo.it.
authors.forename: R
authors.initials: R
authors.lastname: Pasquali
authors.forename: A
authors.initials: A
authors.lastname: Gambineri
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000209:etiology; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D009765:Obesity / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000235:genetics; D015995:Prevalence; D011506:Proteins / Q000235:genetics; D012738:Sex Hormone-Binding Globulin / Q000235:genetics
chemical_list: D011506:Proteins; D012738:Sex Hormone-Binding Globulin; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human