title: Multi-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysis.
abstract: Recently, diffuse speckle contrast analysis (DSCA) was introduced as a competent modality for deep tissue blood flow measurement, where the speckle contrast is calculated over spatial domain on the CCD image of diffuse reflectance. In this paper, we introduce time-domain DSCA where temporal statistics are used for speckle contrast calculation and results in the same deep tissue flow measurement. This new modality is especially suitable for multi-channel real-time flowmetry, and we demonstrate its performance on human arm during cuff occlusion test. Independent component analysis (ICA) study on multi-channel data shows promising results about underlying physiology.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Bi
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Kijoon
authors.initials: K
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D012212:Rheology / Q000379:methods*