title: Periocular cutaneous oncocytoma with signs of disrupted oxygen metabolism.
abstract: Oncocytomas are benign tumors most often occurring in salivary or lacrimal glands and thyroid tissue. As cutaneous oncocytoma is exceptionally rare, this tumor is uncommonly encountered by dermatopathologists. Herein, we illustrate the case of an 80-year-old man who presented with a slowly growing papule of the lower eyelid. Histopathologically, the adenomatous tumor was composed of large monomorphic cells with eosinophilic granular cytoplasm. Electron microscopy revealed abundant, enlarged and abnormally shaped mitochondria. These findings were consistent with an oncocytoma of the skin. The presented case is unique in that the thorough work-up of the tumor tissue revealed not only hyperplastic mitochondria, representing the ultrastructural correlate of the observed granular cytoplasm, but additionally disclosed functional consequences with elevated levels of reactive oxygen specimen (ROS) within the tumor. Disrupted oxygen metabolism may result from cellular aging processes and may putatively represent the underlying pathogenesis of oncocytoma.
authors.affiliation: Department of Dermatology, University Hospital of Wuerzburg, Wuerzburg, Germany.
authors.forename: Marion
authors.initials: M
authors.lastname: Wobser
authors.forename: Sebastian
authors.initials: S
authors.lastname: Haferkamp
authors.forename: Sabine
authors.initials: S
authors.lastname: Roth
authors.forename: Tobias
authors.initials: T
authors.lastname: Meyer-Ter-Vehn
authors.forename: Andrea
authors.initials: A
authors.lastname: Pfister
authors.forename: Tina
authors.initials: T
authors.lastname: Giner
authors.forename: Arno
authors.initials: A
authors.lastname: Rütten
authors.forename: Hermann
authors.initials: H
authors.lastname: Kneitz
authors.forename: Matthias
authors.initials: M
authors.lastname: Goebeler
authors.forename: Eva
authors.initials: E
authors.lastname: Geissinger
mesh_terms: D018249:Adenoma, Oxyphilic / Q000378:metabolism / Q000473:pathology; D000369:Aged, 80 and over; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species; D010100:Oxygen
keywords: ocular adenoma; oncocytoma; oxygen metabolism