title: Dynamic volume perfusion CT in patients with lung cancer: baseline perfusion characteristics of different histological subtypes.
abstract: OBJECTIVE
  To evaluate dynamic volume perfusion CT (dVPCT) tumor baseline characteristics of three different subtypes of lung cancer in untreated patients.
  
  
  METHODS
  173 consecutive patients (131 men, 42 women; mean age 61 ± 10 years) with newly diagnosed lung cancer underwent dVPCT prior to biopsy. Tumor permeability, blood flow (BF), blood volume (BV) and mean transit time (MTT) were quantitatively assessed as well as tumor diameter and volume. Tumor subtypes were histologically determined and compared concerning their dVPCT results. dVPCT results were correlated to tumor diameter and volume.
  
  
  RESULTS
  Histology revealed adenocarcinoma in 88, squamous cell carcinoma in 54 and small cell lung cancer (SCLC) in 31 patients. Tumor permeability was significantly differing between adenocarcinoma, squamous cell carcinoma and SCLC (all p<0.05). Tumor BF and BV were higher in adenocarcinomathan in SCLC (p = 0.001 and p=0.0002 respectively). BV was also higher in squamous cell carcinoma compared to SCLC (p = 0.01). MTT was not differing between tumor subtypes. Regarding all tumors, tumor diameter did not correlate with any of the dVPCT parameters, whereas tumor volume was negatively associated with permeability, BF and BV (r = -0.22, -0.24, -0.24, all p<0.05). In squamous cell carcinoma, tumor diameter und volume correlated with BV (r = 0.53 and r = -0.40, all p<0.05). In SCLC, tumor diameter und volume correlated with MTT (r = 0.46 and r = 0.39, all p<0.05). In adenocarcinoma, no association between morphological and functional tumor characteristics was observed.
  
  
  CONCLUSIONS
  dVPCT parameters are only partially related to tumor diameter and volume and are significantly differing between lung cancer subtypes.
authors.affiliation: Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address: shijingyun89179@126.com.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Shi
authors.forename: Gerald
authors.initials: G
authors.lastname: Schmid-Bindert
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Sonja
authors.initials: S
authors.lastname: Sudarski
authors.forename: Paul
authors.initials: P
authors.lastname: Apfaltrer
authors.forename: Lothar R
authors.initials: LR
authors.lastname: Pilz
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Ulrike
authors.initials: U
authors.lastname: Haberland
authors.forename: Ernst
authors.initials: E
authors.lastname: Klotz
authors.forename: Caicun
authors.initials: C
authors.lastname: Zhou
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000706:statistics & numerical data*; D011652:Pulmonary Circulation; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D047368:Tumor Burden
keywords: Dynamic volume perfusion CT; Functional imaging; Lung cancer; Tumor angiogenesis