title: Two-dimensional hybrid mesoporous Fe2O3-graphene nanostructures: a highly active and reusable peroxidase mimetic toward rapid, highly sensitive optical detection of glucose.
abstract: In this article, for the first time, two-dimensional hybrid mesoporous Fe2O3-graphene (mFe2O3-G) nanostructures were developed as a peroxidase mimetic with catalytic activities superior to those of mFe2O3, G, and previously reported Fe-based peroxidase mimetics. The high-surface-area mFe2O3 not only offers a large number of catalytically active sites, but also facilitates the diffusion of 3,3,5,5-tetramethylbenzidine (TMB) and H2O2 toward G surface. On the other hand, G is π-rich and thus favors the adsorption and enrichment of TMB within these pores. These synergistic effects lead to highly improved catalytic performances. Based on these findings, a simple, rapid, and highly sensitive and selective optical detector of glucose has been developed and demonstrated in buffer solution with a pretty low detection limit of 0.5 μM. In addition, this nanosensor is reusable and can also be used for glucose detection in diluted serum.
authors.affiliation: State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, Jilin, China.
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Xing
authors.forename: Jingqi
authors.initials: J
authors.lastname: Tian
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Asiri
authors.forename: Abdullah H
authors.initials: AH
authors.lastname: Qusti
authors.forename: Abdulrahman O
authors.initials: AO
authors.lastname: Al-Youbi
authors.forename: Xuping
authors.initials: X
authors.lastname: Sun
mesh_terms: D032701:Biomimetics; D001786:Blood Glucose / Q000302:isolation & purification*; D002384:Catalysis; D005290:Ferric Compounds / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry*; D009195:Peroxidase / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D005290:Ferric Compounds; C000499:ferric oxide; D006108:Graphite; D006861:Hydrogen Peroxide; D009195:Peroxidase
keywords: Colorimetric detection; Glucose nanosensor; Mesoporous Fe(2)O(3)–graphene hybrid; Peroxidase mimetic; Synergistic effects