title: Metabolic disorders due to methanol poisoning.
abstract: OBJECTIVE
  The aim of this study is to compare markers of glomerular filtration rate (GFR), estimated GFR (eGFR), and metabolic parameters between admission and recovery in 13 patients of Tomas Bata hospital with methanol poisoning during methanol problems in the Czech Republic in 2012. The impact of methanol concentration and age on metabolic parameters were discovered at the time of admission to hospital.
  
  
  METHODS
  The serum osmolality, methanol, ethanol, creatinine, cystatin C, Troponin I, ALT, plasma pH and lactate were measured in these 13 patients. The eGFR from serum creatinine (creatnine eGFR) and from cystatin C (cystatin C eGFR) were also determined.
  
  
  RESULTS
  Increased serum osmolality and markers of metabolic acidosis are key indirect laboratory findings in patients with methanol poisoning. There were no significant changes in eGFR in our patients between admission and recovery. Increased serum troponin I concentration was confirmed as an indicator of myocardial necrosis in four patients. Two patients developed acute kidney injury (AKI) before admission.
  
  
  CONCLUSIONS
  We found statistically significant differences in serum osmolality concentration, plasma pH and lactate between admission and recovery. We found no changes in eGFR between admission and recovery. One patient had vision problems due to damage to the occipital lobes. Methanol poisoning may cause increase in markers of cardiac damage.
authors.affiliation: Department of Clinical Biochemistry, Tomas Bata Regional Hospital in Zlin a.s., Zlin, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Salek
authors.forename: Petr
authors.initials: P
authors.lastname: Humpolicek
authors.forename: Petr
authors.initials: P
authors.lastname: Ponizil
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D018153:Czech Republic; D005260:Female; D005919:Glomerular Filtration Rate; D006760:Hospitalization; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008875:Middle Aged; D009994:Osmolar Concentration
chemical_list: D015415:Biomarkers; D000432:Methanol