title: Sex-specific effects of cis-regulatory variants in Drosophila melanogaster.
abstract: Sexual dimorphism at the level of gene expression is common and well documented, but much less is known about how different cis-regulatory alleles interact with the different trans-regulatory environments present in males and females. Here we show that sex-specific effects of cis-regulatory variants are common in Drosophila.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Coolon
authors.forename: William
authors.initials: W
authors.lastname: Webb
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Wittkopp
mesh_terms: D000818:Animals; D059006:Chromosomes, Insect / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D018392:Genomic Imprinting; D008297:Male; D012727:Sex Characteristics; D012730:Sex Chromosomes / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins
keywords: allele-specific expression; epistasis; gene regulation; imprinting; trans-regulation