title: Pd(II)-catalyzed ortho-trifluoromethylation of benzylamines.
abstract: The Pd(II)-catalyzed ortho-C-H trifluoromethylation of benzylamines has been achieved utilizing an electrophilic CF3 reagent. Additives, such as H2O and Ag2O, were found to be crucial for obtaining good yields. This protocol will be useful in medicinal chemistry for the preparation of ortho-trifluoromethyl-substituted benzylamines.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Masanori
authors.initials: M
authors.lastname: Miura
authors.forename: Chen-Guo
authors.initials: CG
authors.lastname: Feng
authors.forename: Sandy
authors.initials: S
authors.lastname: Ma
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D008745:Methylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001596:Benzylamines; D009942:Organometallic Compounds; D010165:Palladium