title: Risk of kidney stones with surgical intervention in living kidney donors.
abstract: A kidney stone in a person with a solitary kidney requires urgent attention, which may result in surgical and/or hospital attention. We conducted a matched retrospective cohort study to determine if living kidney donors compared to healthy nondonors have a higher risk of: (i) kidney stones with surgical intervention, and (ii) hospital encounters for kidney stones. We reviewed all predonation charts for living kidney donations from 1992 to 2009 at five major transplant centers in Ontario, Canada, and linked this information to healthcare databases. We selected nondonors from the healthiest segment of the general population and matched 10 nondonors to every donor. Of the 2019 donors and 20 190 nondonors, none had evidence of kidney stones prior to cohort entry. Median follow-up time was 8.4 years (maximum 19.7 years; loss to follow-up <7%). There was no difference in the rate of kidney stones with surgical intervention in donors compared to nondonors (8.3 vs. 9.7 events/10 000 person-years; rate ratio 0.85; 95% confidence interval [CI] 0.47-1.53). Similarly there was no difference in the rate of hospital encounters for kidney stones (12.1 vs. 16.1 events/10 000 person-years; rate ratio 0.75; 95% CI 0.45-1.24). These interim results are reassuring for the safety of living kidney donation.
authors.affiliation: Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Medicine, Division of Nephrology, Western University, London, Ontario, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Thomas
authors.forename: N N
authors.initials: NN
authors.lastname: Lam
authors.forename: B K
authors.initials: BK
authors.lastname: Welk
authors.forename: C
authors.initials: C
authors.lastname: Nguan
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.forename: D M
authors.initials: DM
authors.lastname: Nash
authors.forename: G V R
authors.initials: GV
authors.lastname: Prasad
authors.forename: G A
authors.initials: GA
authors.lastname: Knoll
authors.forename: J J
authors.initials: JJ
authors.lastname: Koval
authors.forename: K L
authors.initials: KL
authors.lastname: Lentine
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: C E
authors.initials: CE
authors.lastname: Lok
authors.forename: A X
authors.initials: AX
authors.lastname: Garg
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007669:Kidney Calculi / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D020858:Tissue and Organ Harvesting
keywords: Cohort study; health administrative data; health outcomes; kidney stones; living kidney donor; transplantation