title: Application of the compressed sensing technique to self-gated cardiac cine sequences in small animals.
abstract: OBJECTIVE
  Self-gated cine sequences are a common choice for cardiac MRI in preclinical applications. The aims of our work were to apply the compressed sensing technique to IntraGateFLASH cardiac MRI studies on rats and to find the maximum acceleration factor achievable with this technique.
  
  
  METHODS
  Our reconstruction method extended the Split Bregman formulation to minimize the total variation in both space and time. In addition, we analyzed the influence of the undersampling pattern on the acceleration factor achievable.
  
  
  RESULTS
  Our results show that acceleration factors of up to 15 are achievable with our technique when appropriate undersampling patterns are used. The introduction of a time-varying random sampling clearly improved the efficiency of the undersampling schemes. In terms of computational efficiency, the proposed reconstruction method has been shown to be competitive as compared with the fastest methods found in the literature.
  
  
  CONCLUSIONS
  We successfully applied our compressed sensing technique to self-gated cardiac cine acquisition in small animals, obtaining an acceleration factor of up to 15 with almost unnoticeable image degradation.
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Montesinos
authors.forename: Juan Felipe P J
authors.initials: JF
authors.lastname: Abascal
authors.forename: Lorena
authors.initials: L
authors.lastname: Cussó
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Vaquero
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
mesh_terms: D000465:Algorithms; D000818:Animals; D016477:Artifacts; D055424:Cardiac-Gated Imaging Techniques / Q000662:veterinary*; D044962:Data Compression / Q000379:methods*; D005260:Female; D006321:Heart / Q000033:anatomy & histology*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000662:veterinary*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: Split Bregman; cardiac cine MRI; compressed sensing; self-gated; total variation; undersampling pattern