title: β-Lactoglobulin improves liposome's encapsulation properties for vitamin E delivery.
abstract: Vitamin E (VE) or α-tocopherol is the major fat-soluble antioxidant in the human body. It is a sensitive, easily oxidized in the air, molecule, so it must be protected from pro-oxidant elements which could affect its physiological benefits. Encapsulation constitutes a promising approach to maintain VE native properties over time and increase its concentration in aqueous media. Liposomes have been studied as sustained delivery systems, being biodegradable, non-toxic and non-immunogenic. A new liposome/β-lactoglobulin (β-Lg) formulation has been developed and characterized as a possible stable delivery system for VE. β-Lg has been selected due to its property to bind a variety of hydrophobic molecules. The aim of this study was the preparation of β-Lg-liposome formulation and the determination of VE encapsulation efficiency, in order to develop a new more efficient carrier for VE in aqueous media.
authors.affiliation: Biochemistry Laboratory, Veterinary Department, University of Thessaly , Karditsa , Greece and.
authors.forename: Magdalini
authors.initials: M
authors.lastname: Rovoli
authors.forename: Olga
authors.initials: O
authors.lastname: Gortzi
authors.forename: Stavros
authors.initials: S
authors.lastname: Lalas
authors.forename: George
authors.initials: G
authors.lastname: Kontopidis
mesh_terms: D000975:Antioxidants; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007782:Lactoglobulins / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000737:chemistry; D014810:Vitamin E / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D004337:Drug Carriers; D007782:Lactoglobulins; D008081:Liposomes; D017382:Reactive Oxygen Species; D014810:Vitamin E