title: Association between urinary IgG and relative risk for factors affecting proteinuria in type 2 diabetic patients.
abstract: Abnormal glomerular permeability is the primary step towards the glomerulosclerosis. The progression rate of glomerulosclerosis is proportionate to abundance and severity of lesions created at incipient stage, which is reflected as proteinuria even though eGFR remains in the normal range. Therefore, there is a current need to find out the association between relative risks for the factors leading to proteinuria. The relations could be more informative, if it is with respect to the macromolecules like "IgG" excretion in urine. Type 2 diabetic patients were selected for this study with eGFR > 75 ml/min/1.73 m(2) and grouped into four quartiles based on UIgGCR. The markers of key factors affecting progression of proteinuria were estimated through biochemical tests. The impact of these markers on proteinuria was accessed by applying multinomial logistic regression. The adjusted odds ratio for the UGAGCR was 1.186 (95 % CI: 1.061-1.327) P < 0.003 in highest quartiles of UIgGCR, followed by odds ratio for markers of collagen catabolism 1.051 (95 % CI: 1.025-1.079) P < 0.001, and USACR 1.044 (95 % CI: 1.013-1.077) P < 0.006 respectively. The marker of glycation, i.e., glycated hemoglobin showed the highest odds ratio 5.449 (95 % CI: 1.132-26.236) P < 0.035. In addition, odds for the systolic blood pressure was observed 1.387 (95 % CI: 1.124-1.712) P < 0.002. The higher odds inform and could help to discriminate the diabetic patients with fast progressive diabetic nephropathy. The study describes critical relationship between the urinary excretion of IgG and factors leading to proteinuria in type 2 diabetic patients.
authors.affiliation: Laboratory of Biochemistry, BRD School of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Post Box No. 39, Anand, 388 120 Gujarat India.
authors.forename: Sandesh
authors.initials: S
authors.lastname: Mohan
authors.forename: Kiran
authors.initials: K
authors.lastname: Kalia
authors.forename: Jyoti
authors.initials: J
authors.lastname: Mannari
keywords: Diabetic nephropathy; Glomerular basement membrane; Proteinuria; Urinary glycosaminoglycans; Urinary sialic acid