title: Lignan glucosides from Sinomenium acutum rhizomes.
abstract: The new lignan glucoside, acutumoside (1), was isolated from Sinomenium acutum rhizomes together with nine known compounds (2-10). The structure of 1 was elucidated on the basis of extensive spectroscopic analyses, including two-dimensional nuclear magnetic resonance and chemical reactions. Compounds 2, 7, 8, and 10 displayed potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines, while compound 1 showed weak activity against these human tumor cells.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Sae Rom
authors.initials: SR
authors.lastname: Moon
authors.forename: Chung Sub
authors.initials: CS
authors.lastname: Kim
authors.forename: Kyeong Wan
authors.initials: KW
authors.lastname: Woo
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D032841:Sinomenium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005960:Glucosides; D017705:Lignans