title: The protective effect of propylthiouracil against hepatotoxicity induced by chromium in adult mice.
abstract: Environmental and occupational exposure to chromium compounds, especially hexavalent chromium (Cr(VI)), is widely recognized as potentially hepatotoxic in humans and animals. Its toxicity is associated with overproduction of free radicals, which induces oxidative damage. This study focused on the possible protective effect of propylthiouracil (PTU) against potassium dichromate (K2Cr2O7). Female mice were divided into four groups (groups I-IV) with seven animals in each group. Group I served as a control, which received tap water; group II received K2Cr2O7 alone (75 mg kg(-1) body weight (b.w.)) via drinking water; group III received both K2Cr2O7 via drinking water and PTU by intramuscular injection at a dose 2.5 mg/100 g(-1) b.w. twice a week, and group IV received PTU alone twice a week for 30 days. Exposure of mice to Cr promoted oxidative stress with an increase in malondialdehyde, protein carbonyl, and advanced oxidation protein product levels. Nonenzymatic antioxidants such as glutathione, nonprotein thiol, vitamin C levels and enzymatic antioxidant activities such as glutathione peroxidase and superoxide dismutase were decreased, while catalase activity was increased. Biomarkers of liver injury such as aspartate and alanine transaminases, lactate dehydrogenase activities, bilirubin, albumin, and glucose levels were increased, while triglyceride and cholesterol levels decreased. Coadministration of PTU restored the above-mentioned parameters to near-normal values. The histological findings confirmed the biochemical results.
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Faculty of Sciences, University of Sfax, Sfax, Tunisia fatmabh11@yahoo.fr.
authors.forename: Fatma
authors.initials: F
authors.lastname: Ben Hamida
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
authors.forename: Afef
authors.initials: A
authors.lastname: Troudi
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
authors.forename: Madiha
authors.initials: M
authors.lastname: Sefi
authors.affiliation: Histopathology Laboratory, CHU Habib Bourguiba, University of Sfax, Sfax, Tunisia.
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.affiliation: Animal Physiology Laboratory, Department of Life Sciences, Faculty of Sciences, University of Sfax, Sfax, Tunisia.
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood; D002857:Chromium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007273:Injections, Intramuscular; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D011192:Potassium Dichromate / Q000633:toxicity; D011441:Propylthiouracil / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D060766:Drinking Water; D012709:Serum Albumin; D014280:Triglycerides; D002857:Chromium; C074702:chromium hexavalent ion; D008315:Malondialdehyde; D011441:Propylthiouracil; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D001205:Ascorbic Acid; D001663:Bilirubin; D011192:Potassium Dichromate
keywords: Propylthiouracil; hepatotoxicity; histopathological studies; mice; potassium dichromate