title: A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population.
abstract: OBJECTIVE
  Recently, a large genome-wide association study has revealed that polymorphism of alleles and genotypes in rs3,764,650 within ABCA7 gene is associated with Alzheimer disease in whites. We conducted a case-control study to investigate whether these susceptible genetic variants are risk factors for sporadic Alzheimer disease (SAD) in Chinese Han population.
  
  
  METHODS
  A total of 633 participants consisting of 350 SAD and 283 nondemented elderly controls matched for sex and age were recruited and genetic variants in ABCA7 (rs3,764,650) were genotyped using DNA sequencing.
  
  
  RESULTS
  On the basis of allele and genotype frequencies in both groups, we found a significant association (P=0.004) between ABCA7 genotypes and SAD in Chinese Han population, and the results were influenced by age and ApoEε4 status. ApoEε4-carrier and aging are linked to enhancing ABCA7 risk-associated SAD. However, the prevalence of the minor allele G in rs3,764,650 within ABCA7 showed no significant difference between the 2 groups in this study.
  
  
  CONCLUSIONS
  ABCA7 (rs3,764,650) was associated with SAD in the Chinese population, with both ApoEε4-carrier and aging being factors enhancing its risk.
authors.affiliation: *Department of Neurology & Institute of Neurology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University §Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Science & Shanghai Jiao Tong University School of Medicine, Shanghai †Department of Neurology, People's Hospital of Jurong City, Jurong, Jiangsu Province ‡Department of Neurology, Jiangsu Province Geriatric Hospital, Nanjing.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Deng
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Ru-Jing
authors.initials: RJ
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C411895:ABCA7 protein, human; D018528:ATP-Binding Cassette Transporters; D053327:Apolipoprotein E4