title: Effect of iodinated contrast media on renal function evaluated with dynamic three-dimensional MR renography.
abstract: OBJECTIVE
  To assess the hemodynamic effect of iodinated contrast media (CM) on glomerular filtration rate (GFR) by using dynamic three-dimensional magnetic resonance (MR) renography in a rabbit model.
  
  
  METHODS
  This study was approved by the university animal care and use committee. Twelve healthy male New Zealand rabbits (body mass range, 2.5-3.0 kg) were included. Two of them were sacrificed before MR examination to obtain renal histologic samples as controls. The other ten rabbits completed 4-minute dynamic contrast material-enhanced MR imaging 24 hours before and 20 minutes after intravenous injection of iopamidol (370 mg of iodine per milliliter) at a dose of 6 mL per kilogram of body weight. Blood volume (V(B)), GFR, and tubule volume (V(E)) of the renal cortex were determined with a two-compartment kinetic model. Maximum upslope (K(m)), peak concentration (P(c)), and initial 60-second area under the curve (IAUC) of the whole kidney renogram curve were measured with semiquantitative analysis. The self-control data were compared by using the Student paired t test.
  
  
  RESULTS
  Iopamidol significantly decreased cortical V(B) (mean, 42.53% ± 10.16 [standard deviation] before CM administration vs 27.23% ± 16.13 after CM administration; P < .01), V(E) (mean, 22.40% ± 11.69 before CM administration vs 11.51% ± 6.58 after CM administration; P < .01), and GFR (mean, 31.92 mL/100 g per minute ± 12.52 before CM administration vs 21.48 mL/100 g per minute ± 10.02 after CM administration; P < .01). Results of whole-kidney renogram analysis showed a decrease in K(m), P(c), and IAUC caused by iopamidol administration.
  
  
  CONCLUSIONS
  High-dose iopamidol resulted in a marked decrease in renal function, which could be detected at dynamic three-dimensional MR renography.
authors.affiliation: From the Center for MRI Research, Peking University, Beijing, China (J.W.); Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China (J.Z.); and Department of Radiology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, China 100034 (Y.D.Z., X.W., X.J.).
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jue
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
authors.forename: Xuexiang
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000465:Algorithms; D000818:Animals; D019540:Area Under Curve; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D007479:Iopamidol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011817:Rabbits
chemical_list: D003287:Contrast Media; D007479:Iopamidol