title: Remembrance of Hugh E. Huxley, a founder of our field.
abstract: Hugh E. Huxley (1924-2013) carried out structural studies by X-ray fiber diffraction and electron microscopy that established how muscle contracts. Huxley's sliding filament mechanism with an ATPase motor protein taking steps along an actin filament, established the paradigm not only for muscle contraction but also for other motile systems using actin and unconventional myosins, microtubules and dynein and microtubules and kinesin.
authors.affiliation: Departments of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut; Departments of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut; Department of Cell Biology, Yale University, New Haven, Connecticut.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Pollard
authors.forename: Yale E
authors.initials: YE
authors.lastname: Goldman
mesh_terms: D049673:History, 20th Century; D049674:History, 21st Century; D046529:Microscopy, Electron, Transmission / Q000266:history* / Q000379:methods; D009119:Muscle Contraction / Q000502:physiology; D006113:United Kingdom; D014961:X-Ray Diffraction / Q000266:history* / Q000379:methods