title: Hemodynamic effects of pressure-volume relation in the atrial contraction model on the total artificial heart using centrifugal blood pumps.
abstract: Hemodynamic effects of atrial contraction with centrifugal pump type total artificial heart is unknown. In this study, we simulated an atrial contraction in a mock model. By the driving condition with higher pressure in the mock atrial model, the load during atrial contraction increased. Based on these findings, we examined atrial contraction in the animal using adult goats. Prior to the measurement, we installed a centrifugal-type ventricular assist device (VADs), and then clamped both ventricles. We measured the hemodynamic data without ventricular contractile functions in order to obtain the effect of atrial contraction on hemodynamics under the condition of the total artificial heart (TAH) circulatory support model. We could estimate the heart rate by revolution number and voltage of pumps. There might be a possibility that we could regulate autonomic nervous response with the control of cardiac output.
authors.forename: Takuya
authors.initials: T
authors.lastname: Shiga
authors.forename: Takehito
authors.initials: T
authors.lastname: Kuroda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tsuboko
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yambe
mesh_terms: D000818:Animals; D016275:Atrial Function; D062185:Atrial Pressure; D002302:Cardiac Output; D002306:Cardiac Volume; D006041:Goats; D006339:Heart Rate; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008954:Models, Biological; D009200:Myocardial Contraction; D016276:Ventricular Function