title: Comprehensive identification of mutational cancer driver genes across 12 tumor types.
abstract: With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous molecular nature of the disease and the limitations of available computational methods. Here we show that the combination of complementary methods allows identifying a comprehensive and reliable list of cancer driver genes. We provide a list of 291 high-confidence cancer driver genes acting on 3,205 tumors from 12 different cancer types. Among those genes, some have not been previously identified as cancer drivers and 16 have clear preference to sustain mutations in one specific tumor type. The novel driver candidates complement our current picture of the emergence of these diseases. In summary, the catalog of driver genes and the methodology presented here open new avenues to better understand the mechanisms of tumorigenesis.
authors.affiliation: 1] Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona, Spain [2].
authors.forename: David
authors.initials: D
authors.lastname: Tamborero
authors.forename: Abel
authors.initials: A
authors.lastname: Gonzalez-Perez
authors.forename: Christian
authors.initials: C
authors.lastname: Perez-Llamas
authors.forename: Jordi
authors.initials: J
authors.lastname: Deu-Pons
authors.forename: Cyriac
authors.initials: C
authors.lastname: Kandoth
authors.forename: Jüri
authors.initials: J
authors.lastname: Reimand
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lawrence
authors.forename: Gad
authors.initials: G
authors.lastname: Getz
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Nuria
authors.initials: N
authors.lastname: Lopez-Bigas
mesh_terms: D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis / Q000379:methods*; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D023281:Genomics / Q000379:methods*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D015203:Reproducibility of Results; D015398:Signal Transduction
chemical_list: D002273:Carcinogens