title: Conformational preferences of zampanolide and dactylolide.
abstract: The solution conformation behavior of the macrolide core of microtubule-stabilizing agents (-)-zampanolide and (-)-dactylolide has been determined through a combination of high-field NMR experiments and computational modeling. Taken together, the results demonstrate that in solution both molecules exist as a mixture of three interconverting conformational families, one of which bears strong resemblance to zampanolide's tubulin-bound conformation.
authors.affiliation: Department of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame , 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, United States.
authors.forename: Erik M
authors.initials: EM
authors.lastname: Larsen
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Wilson
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Zajicek
authors.forename: Richard E
authors.initials: RE
authors.lastname: Taylor
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009010:Monte Carlo Method; D013237:Stereoisomerism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D018942:Macrolides; C451487:dactylolide; C444900:zampanolide