title: Prnp gene and cerebellum volume in patients with refractory mesial temporal lobe epilepsy.
abstract: The cellular prion protein, encoded by Prnp gene, is involved in neuroprotection, neuroplasticity and neurodevelopment. The variant allele Valine at codon 129 of the Prnp was associated with decreased brain volume in healthy volunteers and schizophrenic patients. We investigate the association between the cerebellum volume and the presence of variant allele Valine at codon 129 of the Prnp gene in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). The Prnp coding sequence was determined in 41 refractory MTLE-HS patients. The cerebellum volume corrected by the intracranial volume of patients with the normal Prnp genotypes was compared with that of patients presenting the variant alleles at codon 129. Twenty patients showed the Met129Met genotype, 16 showed Met129Val, and 5 had Val129Val. There were no association among clinical, demographic, electrophysiological, antiepileptic drugs used, and the presence of the Prnp variant alleles. The presence of Prnp variant allele at codon 129 was not associated with the analyzed cerebellum volume. Prnp variant alleles at codon 129 are not associated with cerebellum volume in patients with refractory MTLE-HS.
authors.affiliation: Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
authors.forename: Michelle N
authors.initials: MN
authors.lastname: Valadão
authors.forename: Erica R
authors.initials: ER
authors.lastname: Coimbra
authors.forename: Michele C
authors.initials: MC
authors.lastname: Landemberger
authors.forename: Tonicarlo R
authors.initials: TR
authors.lastname: Velasco
authors.forename: Vera C
authors.initials: VC
authors.lastname: Terra
authors.forename: Lauro
authors.initials: L
authors.lastname: Wichert-Ana
authors.forename: Veriano
authors.initials: V
authors.lastname: Alexandre
authors.forename: David
authors.initials: D
authors.lastname: Araújo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guarnieri
authors.forename: Vilma R
authors.initials: VR
authors.lastname: Martins
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Santos
authors.forename: Américo C
authors.initials: AC
authors.lastname: Sakamoto
authors.forename: Roger
authors.initials: R
authors.lastname: Walz
mesh_terms: D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002531:Cerebellum / Q000473:pathology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D000072002:Prion Proteins; D011328:Prions / Q000235:genetics*; D012640:Seizures / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions