title: Why is ABI effective in detecting vascular stenosis? Investigation based on multibranch hemodynamic model.
abstract: The ankle-brachial index (ABI), defined as the ratio of systolic pressure in the ankle arteries and that in the brachial artery, was a useful noninvasive method to detect arterial stenoses. There had been a lot of researches about clinical regularities of ABI; however, mechanism studies were less addressed. For the purpose of a better understanding of the correlation between vascular stenoses and ABI, a computational model for simulating blood pressure and flow propagation in various arterial stenosis circumstances was developed with a detailed compartmental description of the heart and main arteries. Particular attention was paid to the analysis of effects of vascular stenoses in different large-sized arteries on ABI in theory. Moreover, the variation of ABI during the increase of the stenosis severity was also studied. Results showed that stenoses in lower limb arteries, as well as, brachial artery, caused different variations of blood pressure in ankle and brachial arteries, resulting in a significant change of ABI. Furthermore, the variation of ABI became faster when the severity of the stenosis increased, validating that ABI was more sensitive to severe stenoses than to mild/moderate ones. All these in findings revealed the reason why ABI was an effective index for detecting stenoses, especially in lower limb arteries.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
authors.forename: Shuyu
authors.initials: S
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
authors.forename: Deyu
authors.initials: D
authors.lastname: Li
mesh_terms: D055109:Ankle Brachial Index / Q000379:methods*; D003251:Constriction, Pathologic / Q000175:diagnosis*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical