title: Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.
abstract: Regulated intramembrane proteolysis (RIP) is a signaling mechanism through which transmembrane precursor proteins are cleaved to liberate their cytoplasmic and/or luminal/extracellular fragments from membranes so that these fragments are able to function at a new location. Recent studies have indicated that this proteolytic reaction plays an important role in host-virus interaction. On one hand, RIP transfers the signal from the endoplasmic reticulum (ER) to nucleus to activate antiviral genes in response to alteration of the ER caused by viral infection. On the other hand, RIP can be hijacked by virus to process transmembrane viral protein precursors and to destroy transmembrane antiviral proteins. Understanding this Yin and Yang side of RIP may lead to new strategies to combat viral infection. This article is part of a Special Issue entitled: Intramembrane Proteases.
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9046, USA. Electronic address: jin.ye@utsouthwestern.edu.
authors.forename: Jin
authors.initials: J
authors.lastname: Ye
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology* / Q000276:immunology / Q000821:virology; D002467:Cell Nucleus / Q000276:immunology / Q000378:metabolism / Q000821:virology; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism / Q000821:virology; D005786:Gene Expression Regulation; D016174:Hepacivirus / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D008666:Metalloendopeptidases / Q000235:genetics / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology*; D059748:Proteolysis; D015398:Signal Transduction; D000097625:HLA-E Antigens
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D015395:Histocompatibility Antigens Class I; D008666:Metalloendopeptidases; D009419:Nerve Tissue Proteins; D000097625:HLA-E Antigens; C485618:CREB3L1 protein, human; C120654:MBTPS2 protein, human
keywords: CREB3; CREB3L1; Regulated intramembrane proteolysis; Signal peptide-peptidase; Site-2 protease; Virus