title: [Effect of posteroventral pallidotomy on event-related P300 in Parkinson's disease].
abstract: BACKGROUND
  Ablative procedures are still frequent for the surgical treatment of Parkinson's disease (PD). Although the P300 component has been used to assess cognitive changes induced by levodopa and deep brain stimulation (DBS), the effects caused by unilateral pallidotomy remain unknown.
  
  
  METHODS
  P300 amplitude and latency in 10 PD patients who underwent unilateral pallidotomy with and without levodopa treatment were compared with 10 healthy controls. Measurements in patients were performed 6 months before and after surgery while only once in controls, throughout the 6-month lapse between the comparative measurements performed in patients.
  
  
  RESULTS
  Statistical differences in P300 amplitude and latency were found between the control and PD groups (p < 0.001). On the other hand, there were no differences between the groups with the use of the levodopa treatment or surgery.
  
  
  CONCLUSIONS
  Lack of statistically significant results after six months of pallidotomy or treatment with levodopa suggests an absence of cognitive impairment. Our results obtained with P300 in which safety of surgical treatment has been assessed in PD are consistent with those of other procedures, such as DBS.
authors.affiliation: Departamento de Neurología y Neurocirugía, Laboratorio de Neurocirugía Experimental, Hospital General de México, México, D.F. fiacroj@yahoo.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Santana
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Sandoval
authors.forename: Guadalupe
authors.initials: G
authors.lastname: González
authors.forename: Reyes
authors.initials: R
authors.lastname: Haro
authors.forename: Ylián
authors.initials: Y
authors.lastname: Ramírez
authors.forename: Fiacro
authors.initials: F
authors.lastname: Jiménez Ponce
mesh_terms: D000978:Antiparkinson Agents / Q000494:pharmacology; D018913:Event-Related Potentials, P300 / Q000187:drug effects; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D053860:Pallidotomy / Q000379:methods; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa