title: Evaluation of child with fever without source: review of literature and update.
abstract: Fever is one of the most common reasons for a visit to the primary care provider or the emergency department. Traditionally, clinicians have used various risk-stratification strategies to identify serious bacterial infections (SBI) without an obvious source in febrile children, because missed bacterial infections in such children can result in meningitis, sepsis, and death; therefore, early and accurate identification of SBIs is critical. Infants aged less than 60 to 90 days are at greatest risk of SBI. The epidemiology of SBI continues to evolve, especially after the successful introduction of conjugate vaccines against Streptococcus pneumoniae and Haemophilus influenzae.
authors.affiliation: Division of Emergency Medicine, Carman and Ann Adam Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Arora
authors.forename: Prashant
authors.initials: P
authors.lastname: Mahajan
mesh_terms: D001424:Bacterial Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008403:Mass Screening / Q000379:methods*; D012307:Risk Factors
keywords: Fever; Fever without source; Serious bacterial infection; Tissue culture