title: Re-irradiation for painful bone metastases - a systematic review.
abstract: The purpose of this review was to determine the efficacy of re-irradiation in patients with bone metastases. A literature search was conducted in Ovid Medline, OldMedline, Embase, Embase Classic, and Cochrane Central Register of Controlled Trials using relevant subject headings and keywords such as bone metastases, radiotherapy and palliative care. The resulting articles were sorted for inclusion for palliative external beam radiation retreatment response rate data. The literature search produced 2164 references and 15 articles were included in the final selection. Complete, partial and overall response rates were calculated to be 20%, 50% and 68%, respectively. Information on treatment toxicities was scarce. The efficacy of re-irradiation is comparable to initial radiation treatment. However, aspects of re-irradiation treatment including dose fractionation, related adverse events and toxicities require further corroboration.
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Erin
authors.initials: E
authors.lastname: Wong
authors.affiliation: Mount Vernon Hospital Cancer Centre, Middlesex, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Hoskin
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Gillian
authors.initials: G
authors.lastname: Bedard
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Poon
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Liang
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Henry
authors.initials: H
authors.lastname: Lam
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Horia
authors.initials: H
authors.lastname: Vulpe
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: May
authors.initials: M
authors.lastname: Tsao
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
authors.forename: Natalie
authors.initials: N
authors.lastname: Pulenzas
authors.affiliation: Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada. Electronic address: Edward.Chow@sunnybrook.ca.
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
mesh_terms: D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D019583:Dose Fractionation, Radiation; D006801:Humans; D010146:Pain / Q000209:etiology / Q000532:radiotherapy; D010166:Palliative Care / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D019233:Retreatment
keywords: Bone metastases; Cancer; Re-irradiation