title: WRAMPing up calcium in migrating cells by localized ER transport.
abstract: Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rear detachment, and motility.
authors.affiliation: Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA; Microbiology Doctoral Training Program, Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Mladinich
authors.forename: Anna
authors.initials: A
authors.lastname: Huttenlocher
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D000071818:Wnt-5a Protein
chemical_list: D011518:Proto-Oncogene Proteins; C085389:WNT5A protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D002118:Calcium