title: [Causes and prevention of occupational cancer].
abstract: Cancer is the leading cause of death in Japan, and is responsible for 30 % of all deaths. Among these deaths, the contributing rate of occupational cancer is only a few percent. However, it is a serious problem for workers exposed to certain carcinogens within the workplace, because they are subjected to high levels of carcinogens throughout their workday. The early adverse health effects exerted by carcinogens are closely related to carcinogenesis. As biomarkers for cancer prevention, 8-hydroxydeoxyguanosine, as an oxidative stress marker, DNA adducts, and cytosine C-5 methylation, as a marker of epigenetic change, may be useful to monitor.
authors.affiliation: Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kawai
mesh_terms: D018736:DNA Adducts; D004249:DNA Damage; D019175:DNA Methylation; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000209:etiology*; D009784:Occupational Diseases / Q000517:prevention & control*
chemical_list: D018736:DNA Adducts