title: Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics.
abstract: A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains displayed significant antimycotic activity.
authors.affiliation: Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Krauss
authors.forename: Carina
authors.initials: C
authors.lastname: Gratzl
authors.forename: Verena
authors.initials: V
authors.lastname: Sturm
authors.forename: Christoph
authors.initials: C
authors.lastname: Müller
authors.forename: Verena
authors.initials: V
authors.lastname: Staudacher
authors.forename: Christoph Q
authors.initials: CQ
authors.lastname: Schmidt
authors.forename: Franz
authors.initials: F
authors.lastname: Bracher
keywords: Antimycotics; Ergosterol biosynthesis; Grignard reaction; Sterol biosynthesis inhibitors