title: Real-time rendering of drug injection and interactive simulation of vessel deformation using GPU.
abstract: Developing patient specific model for the simulation of chemotherapy drug injection is important in medical application. This paper proposed a two-phase fluidic method to simulate chemotherapy drug injection and an improved lumped element method to simulate deformation of vessel at real-time by using GPU for general computing. Firstly, a three-dimensional (3-D) model of hepatic vessels is reconstructed from clinical CT-images using multi-layer method. A 3-D thinning algorithm based on Valence Driven Spatial Median (VDSM) is applied to generate unit-width skeleton of the vessel tree. The two-phase flow simulation of drug injection is based on Hagen-Poiseuille model by introducing a friction factor using bubbly flow Reynolds number. The improved lumped element method achieves good simulation realism at high computational speed to simulate deformable object. Real-time rendering and interaction of vessel deformation, self collision, and surface tearing has been realized and demonstrated in a virtual experiment.
authors.forename: Jichuan
authors.initials: J
authors.lastname: Wu
authors.forename: Chee Kong
authors.initials: CK
authors.lastname: Chui
authors.forename: P Nguyen
authors.initials: PN
authors.lastname: Binh
authors.forename: Chee Leong
authors.initials: CL
authors.lastname: Teo
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001808:Blood Vessels / Q000187:drug effects*; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007267:Injections; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008953:Models, Anatomic; D008962:Models, Theoretical; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014584:User-Computer Interface
chemical_list: D000970:Antineoplastic Agents