title: Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature.
abstract: Keloid disease (KD) is a common, benign, dermal fibroproliferative growth of unknown aetiology. Lesions tend to grow over time; they often recur following therapy and do not regress spontaneously. KD causes considerable discomfort due to pain, pruritus and inflammation, and a significant psychosocial impact with reduced quality of life. It is unique to humans and occurrence is higher in individuals with dark, pigmented, ethnic skin. There is a strong familial heritability, with a high ethnic predisposition in individuals of African, Asian and Hispanic descent. High recurrence rates and unknown resolution rates present a major problem for both the patient and clinician. Many treatment modalities exist; however, there is no single advocated therapy. Therefore, the aim of this review was to explore the most current literature regarding the range of treatment options for KD and to offer a structured approach in the management of KD, based on evidence and experience, to aid clinicians in their current practice. A focused history involving careful evaluation of the patient's symptoms, signs, quality of life and psychosocial well-being should direct targeted therapy, complemented with regular follow-up and re-evaluation. Many treatment modalities, such as intralesional steroid injection, silicone gel application, cryotherapy, lasers, 5-fluorouracil and, relatively recently, photodynamic therapy, are currently being used in clinical practice for the management of KD. Combination therapies have also been shown to be beneficial. However, there is a lack of robust, randomized, level-one, evidence-controlled trials evaluating these treatment options. Management of KD in ethnic pigmented skin remains a clinical challenge. Thus, a strategic approach with structured assessment, targeted therapy and focus on prevention of recurrence is highly recommended. Quality evidence is essential in order to tailor treatment effectively for the ethnic patient presenting with KD.
authors.affiliation: Plastic and Reconstructive Surgery Research, Bayat Research Group, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, U.K; University Hospital of South Manchester NHS Foundation Trust, Institute of Inflammation and Repair, Dermatology Group, Faculty of Medical and Human Sciences, University of Manchester,  Manchester Academic Health Science Centre, Manchester, M23 9LT, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Ud-Din
authors.forename: A
authors.initials: A
authors.lastname: Bayat
mesh_terms: D000634:Aminoquinolines / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D003452:Cryosurgery / Q000379:methods; D003879:Dermatologic Agents / Q000008:administration & dosage; D004558:Electric Stimulation / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077271:Imiquimod; D015552:Injections, Intralesional; D007627:Keloid / Q000208:ethnology / Q000473:pathology / Q000628:therapy*; D008487:Medical History Taking / Q000379:methods; D010778:Photochemotherapy / Q000379:methods; D010808:Physical Examination / Q000379:methods; D055502:Secondary Prevention; D020034:Silicone Gels / Q000008:administration & dosage; D013256:Steroids / Q000008:administration & dosage
chemical_list: D000634:Aminoquinolines; D003879:Dermatologic Agents; D020034:Silicone Gels; D013256:Steroids; D001761:Bleomycin; D000077271:Imiquimod; D005472:Fluorouracil