title: Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma.
abstract: OBJECTIVE
  To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS).
  
  
  METHODS
  We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phase II, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model of comprehensive treatment (surgery, chemotherapy, external radiotherapy, 125I radioactive particle implantation, and autologous peripheral blood stem-cell transplantation).
  
  
  RESULTS
  Follow-up was conducted until March 2013, with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, the ≥3-year estimated survival rate was 77%, and the 5-year estimated survival rate was 70.6%.
  
  
  CONCLUSIONS
  The multidisciplinary collaborative model can be a safe and effective approach to the comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumor remission rate.
authors.affiliation: Key Laboratory of Beijing Ophthalmology and Visual Science, Beijing Tongren Eye Center, Affiliated Beijing Tongren Hospital of Capital Medical University, Beijing, China E-mail : jmma@sina.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Ge
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
authors.forename: Ji-Tong
authors.initials: JT
authors.lastname: Shi
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007390:International Agencies; D008297:Male; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate