title: Effects of ezetimibe on serum polyunsaturated fatty acids in patients with coronary artery disease.
abstract: Residual risk of cardiovascular disease might stem, at least partially, from low serum concentrations of n-3 polyunsaturated fatty acid (PUFA). The purpose of this study was to evaluate the effects of ezetimibe on serum lipids and PU-FAs in patients with coronary artery disease who were intolerant of new or high-dose statin therapy. The study population consisted of 13 patients who were intolerant of new statin therapy and 10 patients who were intolerant of high-dose statin therapy for the treatment of low-density lipoprotein (LDL) cholesterol. Patients who were intolerant of high-dose statin therapy continued taking a statin, but at a lower dose during the study period. Blood samples were collected before and 12 weeks after ezetimibe (10 mg). We measured serum lipids and PUFAs including dihomo-γ-linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid. Ezetimibe significantly decreased LDL cholesterol (138 ± 19 mg/dL to 97 ± 34 mg/dL, P < 0.01), but did not significantly affect high-density lipoprotein cholesterol, triglyceride, or any of the PUFAs measured during the follow-up period. Consequently, it did not affect the ratio of EPA to AA (0.40 ± 0.17 to 0.43 ± 0.18, P = ns) or the ratio of n-3 PUFA to n-6 PUFA (1.10 ± 0.39 to 1.09 ± 0.36, P = ns) during the follow-up period. Ezetimibe in combination with a low-dose statin, or as monotherapy in statin-intolerant patients, decreased LDL cholesterol, but did not significantly affect serum PUFA concentrations in patients with coronary artery disease.
authors.affiliation: Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kurisu
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimonaga
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Naoya
authors.initials: N
authors.lastname: Mitsuba
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Dohi
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kihara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000924:Anticholesteremic Agents / Q000097:blood / Q000627:therapeutic use*; D001384:Azetidines / Q000097:blood / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy*; D000069438:Ezetimibe; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D005231:Fatty Acids, Unsaturated; D000069438:Ezetimibe