title: Oxidant-antioxidant balance in the blood of patients with chronic obstructive pulmonary disease after smoking cessation.
abstract: The effect of smoking cessation on the oxidative stress in patients with chronic obstructive pulmonary disease (COPD) was assessed. We recruited 73 smokers with COPD (study group), whose blood was analysed before smoking cessation, after the 1st, 2nd, and 3rd months of abstinence, 35 healthy nonsmokers (Control I), and 35 smokers with COPD (Control II). Blood was taken once in Control I and 4 times (every month) in Control II. In the study group conjugated dienes (CDs) level in plasma and erythrocytes before smoking cessation was 3 and 6.5 times higher than in Control I, respectively (P < 0.001), while thiobarbituric acid-reactive substances (TBARS) level was 89% (P < 0.001) and 51% higher (P < 0.01), respectively. Superoxide dismutase (SOD) activity was 40% higher (P < 0.05) while glutathione peroxidase (GPx) was 41% lower (P < 0.001) than in Control I. In Control II, the similar differences as compared to Control I were observed throughout the study. Smoking cessation resulted in decrease of CDs, TBARS, and SOD and GPx increase, with no changes in catalase and vitamins A and E. COPD is accompanied by oxidative stress. A three-month tobacco abstinence facilitated restoring the oxidant-antioxidant balance systemically, but it did not affect spirometric parameters.
authors.affiliation: Collegium Medicum of Nicolaus Copernicus University, Karłowicza 24, 85-092 Bydgoszcz, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Woźniak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Górecki
authors.forename: Michał
authors.initials: M
authors.lastname: Szpinda
authors.forename: Celestyna
authors.initials: C
authors.lastname: Mila-Kierzenkowska
authors.forename: Bartosz
authors.initials: B
authors.lastname: Woźniak
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D016540:Smoking Cessation; D013147:Spirometry; D013223:Statistics as Topic; D014815:Vitamins / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D014815:Vitamins