title: Influence of active dendrites on firing patterns in a retinal ganglion cell model.
abstract: Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.
authors.forename: Tianruo
authors.initials: T
authors.lastname: Guo
authors.forename: David
authors.initials: D
authors.lastname: Tsai
authors.forename: Sinisa
authors.initials: S
authors.lastname: Sovilj
authors.forename: John W
authors.initials: JW
authors.lastname: Morley
authors.forename: Gregg J
authors.initials: GJ
authors.lastname: Suaning
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D000818:Animals; D003712:Dendrites / Q000502:physiology*; D007473:Ion Channels; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology*
chemical_list: D007473:Ion Channels