title: Clinical validation of the planar radionuclide ventriculography in patients with right ventricular dysfunction.
abstract: OBJECTIVE
  Gated radionuclide ventriculography (RNV) may be used for the evaluation of the right ventricular function. However, the accuracy of the method should be clinically validated in patients suffering from diseases with specific pathology of the right ventricle (RV) and with possible left ventricular (LV) interaction.
  
  
  METHODS
  Three groups of 15 patients each, diagnosed with arrhythmogenic right ventricular dysplasia (ARVD), pulmonary artery hypertension (PAH) or atrial septal defect (ASD) were compared to a group of normal subjects. The parameters for both ventricles were evaluated separately (ejection fractions: LVEF and RVEF, and intraventricular synchronism quantified as phase standard deviation: LVPSD and RVPSD) as well as the relation or interdependence of the right to left ventricle (RV/LV volume ratio, LV/RV ejection fraction and stroke volume ratios, and interventricular synchronism). All the variables as a whole were analyzed to identify groups of patients according to their functional behaviour.
  
  
  RESULTS
  Significant differences were found between the patients and control group for the RV function while the LV function remained mostly within normal limits. When the RV function was considered, the control group and ASD patient group showed differences regarding the ARVD and PAH patients. On evaluating the RV/LV ratios, differences were found between the control group and the ASD group. In the PAH patients, LV function showed differences in relation to the rest of the groups.
  
  
  CONCLUSIONS
  RNV is a reliable clinical tool to evaluate RV function in patients with RV abnormality.
authors.affiliation: Service de Médecine nucléaire, Groupement Hospitalier Est, Hospices civils de Lyon and Université Claude Bernard, Lyon 1, France. Electronic address: laurence.bontemps@chu-lyon1.fr.
authors.forename: L
authors.initials: L
authors.lastname: Bontemps
authors.forename: Y
authors.initials: Y
authors.lastname: Merabet
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: R
authors.initials: R
authors.lastname: Itti
mesh_terms: D000293:Adolescent; D000368:Aged; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000000981:diagnostic imaging*; D002648:Child; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015635:Radionuclide Ventriculography; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: ARVD; ASD; Analysis of clustering; Análisis de conglomerados; Arrhythmogenic right ventricular dysplasia; Atrial septal defect; Defecto septal atrial; Displasia arritmogénica del ventrículo derecho; Hipertensión arterial pulmonar; IVD; LV; LVEF; LVPM; LVPSD; LVSV; PAH; Pulmonary artery hypertension; RNV; RV; RVEF; RVPM; RVPSD; RVSV; Radionuclide ventriculography; Right ventricular; SOM; SPECT; Ventriculografia isotópica; Ventrículo derecho; arrhythmogenic right ventricular dysplasia; atrial septal defect; interventricular dyssynchrony; left ventricle; left ventricular ejection fraction; left ventricular phase mean; left ventricular phase standard deviation; left ventricular stroke volume; pulmonary artery hypertension; radionuclide ventriculography; right ventricle; right ventricular ejection fraction; right ventricular phase mean; right ventricular phase standard deviation; right ventricular stroke volume; self organizing map; single photon emission computed tomography