title: Temporal and spatial compartmentalization of drug-resistant cytomegalovirus (CMV) in a child with CMV meningoencephalitis: implications for sampling in molecular diagnosis.
abstract: We describe a case of antiviral-resistant cytomegalovirus meningoencephalitis occurring after hematopoietic stem cell transplantation. Antiviral-resistant cytomegalovirus was identified in blood 16 months earlier. However, wild-type cytomegalovirus was evidenced in blood when the meningoencephalitis was diagnosed. Treatment of meningoencephalitis should be adapted to all previously identified resistance mutations in any compartment.
authors.affiliation: Unité d'immunologie, hématologie et rhumatologie pédiatrique, Assistance publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.forename: David
authors.initials: D
authors.lastname: Boutolleau
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: Fabien
authors.initials: F
authors.lastname: Touzot
authors.forename: Guilhem
authors.initials: G
authors.lastname: Cros
authors.forename: Sebastien
authors.initials: S
authors.lastname: Heritier
authors.forename: Despina
authors.initials: D
authors.lastname: Moshous
authors.forename: Benedicte
authors.initials: B
authors.lastname: Neven
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Stephane
authors.initials: S
authors.lastname: Blanche
mesh_terms: D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology*; D001769:Blood / Q000821:virology; D003587:Cytomegalovirus / Q000187:drug effects / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D024882:Drug Resistance, Viral; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000821:virology*; D016133:Polymerase Chain Reaction; D013997:Time Factors; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D014764:Viral Proteins