title: Gelatin powders accelerate the resorption of calcium phosphate cement and improve healing in the alveolar ridge.
abstract: The aim of this study was to show the effectiveness of combining calcium phosphate cement and gelatin powders to promote bone regeneration in the canine mandible. We mixed gelatin powders with calcium phosphate cement to create a macroporous composite. In four beagle dogs, two saddle-type bone defects were created on each side of the mandible, and calcium phosphate cement alone or calcium phosphate cement containing composite gelatin powders was implanted in each of the defects. After a healing period of six months, mandibles were removed for µCT and histological analyses. The µCT and histological analyses showed that at experimental sites at which calcium phosphate cement alone had been placed new bone had formed only around the periphery of the residual calcium phosphate cement and that there had been little or no ingrowth into the calcium phosphate cement. On the other hand, at experimental sites at which calcium phosphate cement containing composite gelatin powders had been placed, we observed regenerated new bone in the interior of the residual calcium phosphate cement as well as around its periphery. The amount of resorption of calcium phosphate cement and bone regeneration depended on the mixing ratio of gelatin powders to calcium phosphate cement. New bone replacement was significantly better in the sites treated with calcium phosphate cement containing composite gelatin powders than in those treated with calcium phosphate cement alone.
authors.affiliation: 1Division of Oral Surgery, Kanagawa Dental University, Yokohama Clinical Education Center, Yokohama, Japan.
authors.forename: Goichi
authors.initials: G
authors.lastname: Matsumoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Sugita
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Kubo
authors.forename: Waka
authors.initials: W
authors.lastname: Yoshida
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Ikada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sobajima
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Hatsuhiko
authors.initials: H
authors.lastname: Maeda
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000539:Alveolar Process / Q000503:physiopathology*; D000818:Animals; D001843:Bone Cements; D002130:Calcium Phosphates / Q000737:chemistry*; D004285:Dogs; D005260:Female; D005780:Gelatin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011208:Powders; D014945:Wound Healing; D055114:X-Ray Microtomography
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D011208:Powders; D005780:Gelatin; C020243:calcium phosphate
keywords: Calcium phosphate cement; bone augmentation; bone regeneration; gelatin powders; interconnected macropores