title: MicroRNA target identification: lessons from hypoxamiRs.
abstract: CONCLUSIONS
  MicroRNAs (miRNAs) are small noncoding RNAs that have emerged as key regulators of many physiological and pathological processes, including those relevant to hypoxia such as cancer, neurological dysfunctions, myocardial infarction, and lung diseases.
  
  
  BACKGROUND
  During the last 5 years, miRNAs have been shown to play a role in the regulation of the cellular response to hypoxia. The identification of several bona fide targets of these hypoxamiRs has underlined their pleiotropic functions and the complexity of the molecular rules directing miRNA::target transcript pairing.
  
  
  RESULTS
  This review outlines the main in silico and experimental approaches used to identify the targetome of hypoxamiRs and presents new recent relevant methodologies for future studies.
  
  
  CONCLUSIONS
  Since hypoxia plays key roles in many pathophysiological conditions, the precise characterization of regulatory hypoxamiRs networks will be instrumental both at a fundamental level and for their future potential therapeutic applications.
authors.affiliation: 1 Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) , Centre National de la Recherche Scientifique, CNRS UMR 7275, Sophia Antipolis, France .
authors.forename: Thomas
authors.initials: T
authors.lastname: Bertero
authors.forename: Karine
authors.initials: K
authors.lastname: Robbe-Sermesant
authors.forename: Kevin
authors.initials: K
authors.lastname: Le Brigand
authors.forename: Gilles
authors.initials: G
authors.lastname: Ponzio
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pottier
authors.forename: Roger
authors.initials: R
authors.lastname: Rezzonico
authors.forename: Nathalie M
authors.initials: NM
authors.lastname: Mazure
authors.forename: Pascal
authors.initials: P
authors.lastname: Barbry
authors.forename: Bernard
authors.initials: B
authors.lastname: Mari
mesh_terms: D000818:Animals; D001483:Base Sequence; D025461:Feedback, Physiological; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D040901:Proteomics; D034622:RNA Interference; D017422:Sequence Analysis, DNA; D012984:Software
chemical_list: D035683:MicroRNAs