title: A technique using 99mTc-mebrofenin SPECT for radiotherapy treatment planning for liver cancers or metastases.
abstract: Radiotherapy or stereotactic body radiosurgery (SBRT) requires a sufficient functional liver volume to tolerate the treatment. The current study extended the work of de Graaf et al. (2010) [3] on the use of (99m)Tc-mebrofenin imaging for presurgery planning to radiotherapy planning for liver cancer or metastases. Patient was immobilized and imaged in an identical position on a single-photon emission computed tomography/computed tomography (SPECT-CT) system and a radiotherapy simulation CT system. (99m)Tc-mebrofenin SPECT was registered to the planning CT through image registration of noncontrast CT from SPECT-CT system to the radiotherapy planning CT. The voxels with higher uptake of (99m)Tc-mebrofenin were transferred to the planning CT as an avoidance structure in optimizing a 2-arc RapidArc plan for SBRT delivery. Excellent dose coverage to the target and sparing of the healthy remnant liver volume was achieved. This report illustrated a procedure for the use of (99m)Tc-mebrofenin SPECT for optimizing radiotherapy for liver cancers and metastases.
authors.affiliation: Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL. Electronic address: sshen@uabmc.edu.
authors.forename: Sui
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Rojymon
authors.initials: R
authors.lastname: Jacob
authors.affiliation: Nuclear Medicine Division, Department of Radiology, VA Medical Center, Birmingham, AL.
authors.forename: Luvenia W
authors.initials: LW
authors.lastname: Bender
authors.affiliation: Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Jun
authors.initials: J
authors.lastname: Duan
authors.affiliation: Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Spencer
mesh_terms: D000814:Aniline Compounds; D005998:Glycine; D006801:Humans; D007098:Imino Acids; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011300:Preoperative Care / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; C034837:technetium Tc 99m mebrofenin; D005998:Glycine
keywords: Functional image-guided radiotherapy; Liver cancer; Treatment planning