title: Antineutrophil cytoplasmic antibody-associated vasculitis involving diffuse alveolar hemorrhage, rapidly progressive glomerulonephritis and hypereosinophilia.
abstract: The classification of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has limitations because the condition includes disorders with similar general clinical features, similar characteristics of lung and renal involvement and a positive ANCA serology. A 40-year-old woman was admitted to our hospital for hemoptysis and dyspnea. She had no history of bronchial asthma. Laboratory examinations revealed hypereosinophilia, positive anti-myeloperoxidase antibodies, hematuria and proteinuria. The patient was ultimately diagnosed with AAV associated with diffuse alveolar hemorrhage, rapidly progressive glomerulonephritis and hypereosinophilia without bronchial asthma. Obtaining a definitive diagnosis of ANCA vasculitis can be very difficult, and the characteristics of this case were not compatible with the findings of typical AVV. We herein report a rare case of AVV.
authors.affiliation: Division of Pulmonary Medicine, Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kamata
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Koh
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kunimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Chiyotani
authors.forename: Koichi
authors.initials: K
authors.lastname: Sayama
authors.forename: Naoki
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Makio
authors.initials: M
authors.lastname: Mukai
mesh_terms: D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006470:Hemorrhage / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011650:Pulmonary Alveoli / Q000473:pathology*