title: Limited spillover to humans from West Nile Virus viremic birds in Atlanta, Georgia.
abstract: West Nile Virus (WNV) is a mosquito-borne pathogen that impacts the health of its passerine bird hosts as well as incidentally infected humans in the United States. Intensive enzootic activity among the hosts and vectors does not always lead to human outbreaks, as is the situation throughout much of the southeastern United States. In Georgia, substantial yearly evidence of WNV in the mosquito vectors and avian hosts since 2001 has only led to 324 human cases. Although virus has been consistently isolated from mosquitoes trapped in Atlanta, GA, little is known about viral activity among the passerine hosts. A possible reason for the suppression of WNV spillover to humans is that viremic birds are absent from high human-use areas of the city. To test this hypothesis, multiseason, multihabitat, longitudinal WNV surveillance for active WNV viremia was conducted within the avian host community of urban Atlanta by collection of blood samples from wild passerine birds in five urban microhabitats. WNV was isolated from the serum of six blood samples collected from 630 (0.95%) wild passerine birds in Atlanta during 2010-2012, a proportion similar to that found in the Chicago, IL, area in 2005, when over 200 human cases were reported. Most of the viremic birds were Northern Cardinals, suggesting they may be of particular importance to the WNV transmission cycle in Georgia. Results indicated active WNV transmission in all microhabitats of urban Atlanta, except in the old-growth forest patches. The number of viremic birds was highest in Zoo Atlanta, where 3.5% of samples were viremic. Although not significant, these observations may suggest a possible transmission reduction effect of urban old-growth forests and a potential role in WNV amplification for Zoo Atlanta. Overall, spillover to humans remains a rare occurrence in urban Atlanta settings despite active WNV transmission in the avian population.
authors.affiliation: 1 Emory University , Department of Environmental Studies and Graduate Division of Biological and Biomedical Sciences Program in Population Biology, Ecology, and Evolution, Atlanta, Georgia .
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Levine
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Mead
authors.forename: Uriel D
authors.initials: UD
authors.lastname: Kitron
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D009033:Culicidae / Q000821:virology; D017753:Ecosystem; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D008137:Longitudinal Studies; D046109:Passeriformes / Q000821:virology; D012621:Seasons; D014505:Urban Population; D014766:Viremia / Q000662:veterinary; D014901:West Nile Fever / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary*; D014902:West Nile virus / Q000302:isolation & purification*; D015047:Zoonoses