title: Effects of high-fluoride dentifrice (5,000-ppm) on caries-related plaque and salivary variables.
abstract: OBJECTIVE
  The aim of the present study was to measure the effects of a 5,000-ppm F toothpaste on caries-related factors in dental plaque and saliva.
  
  
  METHODS
  A 6-week clinical trial was designed with a total of 34 participants, of which 26 completed the study. The participants were assessed on four visits, 2 weeks apart. Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed. Chair-side tests were performed to register the lactic acid production rate on the tongue using Clinpro™ Cario L-Pop™, approximal plaque pH using the pH "strip method" and salivary buffer capacity and counts of cariogenic microorganisms using CRT Buffer(®) and CRT Bacteria(®).
  
  
  RESULTS
  Six weeks' use of 5,000-ppm fluoridated (F) toothpaste significantly increased the approximal fluid F concentration (p < 0.05). There was a significant decrease in lactic acid production rate on the tongue assessed by Clinpro™ (p < 0.05). This was accompanied by changes in interproximal plaque acidogenicity, including significant reductions in AUC(5.7), AUC(6.2) and maximum pH fall and an increase in minimum pH (p < 0.05). A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p < 0.05).
  
  
  CONCLUSIONS
  The present study demonstrates the ability of 5,000-ppm F toothpaste to modify caries-related factors in dental plaque and saliva.
  
  
  CONCLUSIONS
  The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future.
authors.affiliation: Department of Cariology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Box 450, SE-405 30, Gothenburg, Sweden, alaa.mannaa@odontologi.gu.se.
authors.forename: Alaa
authors.initials: A
authors.lastname: Mannaa
authors.forename: Anette
authors.initials: A
authors.lastname: Carlén
authors.forename: Egija
authors.initials: E
authors.lastname: Zaura
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Buijs
authors.forename: Sahar
authors.initials: S
authors.lastname: Bukhary
authors.forename: Peter
authors.initials: P
authors.lastname: Lingström
mesh_terms: D000293:Adolescent; D003731:Dental Caries / Q000503:physiopathology*; D003773:Dental Plaque; D003802:Dentifrices; D005459:Fluorides / Q000008:administration & dosage*; D006801:Humans; D012463:Saliva
chemical_list: D003802:Dentifrices; D005459:Fluorides