title: The impact of loop electrosurgical excision procedure (LEEP) for CIN 2,3 on spontaneous preterm delivery in twin pregnancies by assisted reproductive technique: preliminary data.
abstract: The objective of this study was to compare the frequency of spontaneous preterm delivery before 35 weeks in 7 dichorionic twin pregnancies obtained after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2,3 with respect to 21 twin pregnancies without previous cervical treatment. All the pregnancies were obtained after assisted reproduction techniques (ART). Same age at delivery was observed between two groups (p = 0.81) and none of our twin pregnancies after LEEP had a threatened preterm labor while four controls (19%) underwent a spontaneous preterm delivery (p = 0.35). These preliminary data seem to indicate that LEEP may not be responsible of spontaneous preterm delivery in twin pregnancies subsequent to ART.
authors.affiliation: Woman's Health Sciences Department, Polytechnic University of Marche , Ancona , Italy and.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ciavattini
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Stortoni
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancioli
authors.forename: Danila
authors.initials: D
authors.lastname: Puglia
authors.forename: Andrea Luigi
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Carlo Antonio
authors.initials: CA
authors.lastname: Liverani
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004598:Electrosurgery / Q000009:adverse effects* / Q000379:methods; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D010865:Pilot Projects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology / Q000601:surgery*; D059285:Pregnancy, Twin / Q000706:statistics & numerical data; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*
keywords: Assisted reproduction techniques; cervical treatment; loop electrosurgical excision procedure; preterm delivery; twin pregnancies