title: Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.
abstract: Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and external solar time. We found that circadian rhythms of behavior (locomotor activity), clock gene expression, and body temperature immediately reentrained to phase-shifted light-dark cycles in mice lacking vasopressin receptors V1a and V1b (V1a(-/-)V1b(-/-)). Nevertheless, the behavior of V1a(-/-)V1b(-/-) mice was still coupled to the internal clock, which oscillated normally under standard conditions. Experiments with suprachiasmatic nucleus (SCN) slices in culture suggested that interneuronal communication mediated by V1a and V1b confers on the SCN an intrinsic resistance to external perturbation. Pharmacological blockade of V1a and V1b in the SCN of wild-type mice resulted in accelerated recovery from jet lag, which highlights the potential of vasopressin signaling as a therapeutic target for management of circadian rhythm misalignment, such as jet lag and shift work.
authors.affiliation: Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Mizoro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kori
authors.forename: Kazuki
authors.initials: K
authors.lastname: Okada
authors.forename: Yulin
authors.initials: Y
authors.lastname: Chen
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Fustin
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Yamazaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Mizuguchi
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Dong
authors.forename: Gozoh
authors.initials: G
authors.lastname: Tsujimoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okuno
authors.forename: Masao
authors.initials: M
authors.lastname: Doi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okamura
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001831:Body Temperature / Q000235:genetics; D056926:CLOCK Proteins / Q000235:genetics; D002450:Cell Communication / Q000187:drug effects / Q000235:genetics; D002478:Cells, Cultured; D002940:Circadian Rhythm / Q000235:genetics; D005786:Gene Expression Regulation; D020179:Jet Lag Syndrome / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D017483:Receptors, Vasopressin / Q000235:genetics*; D013493:Suprachiasmatic Nucleus / Q000503:physiopathology
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D017483:Receptors, Vasopressin; D056926:CLOCK Proteins