title: Concurrence of anorexia nervosa and Noonan syndrome.
abstract: Noonan syndrome (NS) is a genetic disease inherited in an autosomal dominant mode; it presents significant genetic heterogeneity and varying penetrance. Mutations have been identified in several genes, and they account for 75% of all known cases. The majority of reported mutations are localized on PTPN11 gene, which encodes the non-receptor type protein tyrosine phosphatase SHP-2. Diagnosis, however, is mainly established after clinical examination. Anorexia nervosa (AN) is an eating disorder characterized by fear of gaining weight, refusal to maintain normal body weight and distorted perceptions of body image or body shape. AN is independently predicted by female sex and feeding problems in childhood, whereas NS symptoms include feeding difficulties. No comorbidity between NS and AN has been reported to date. The authors reported the case of a 38-year-old female patient with AN who met the van der Burgt criteria for NS with confirmed (a) comorbidity of AN and NS and (b) the absence of the most common mutation in PTPN11 and presence of a novel T > A transversion within intron 8-9.
authors.affiliation: Department of Psychiatry, School of Medicine, Democritus University of Thrace, Greece.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Arvaniti
authors.forename: Maria
authors.initials: M
authors.lastname: Samakouri
authors.forename: Flora
authors.initials: F
authors.lastname: Keskeridou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Veletza
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D009154:Mutation; D009634:Noonan Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics
chemical_list: D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases
keywords: Noonan syndrome; anorexia nervosa; comorbidity