title: Association of XPC gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects.
abstract: OBJECTIVE
  Polymorphisms of xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on prostate cancer (PCa) risk. The aim of our study was to evaluate the impact of XPC gene polymorphisms on PCa risk by using a meta-analysis.
  
  
  METHODS
  Data were collected from the following electronic databases: PubMed, EMBASE, Elsevier Science Direct, Cochrane Library, and CNKI, with the last report up to April 30, 2013. Odds ratios with 95% confidence intervals were used to assess the strength of the association.
  
  
  RESULTS
  A total of five separate case-control studies (1966 cases and 1970 controls) were included in this meta-analysis. Meta-analysis was performed for the rs2228001 and PAT+/-polymorphisms. We did not detect a significant association between rs2228001 polymorphism and PCa (p>0.05). Similar results were found in stratification analyses by ethnicity and tumor stage. We detected a significant association of PAT+/-polymorphism with PCa (p<0.05). In stratification analysis, we did not detect a significant association of PAT+/-polymorphism with risk of bone metastasis in PCa patients (p>0.05).
  
  
  CONCLUSIONS
  These analyses suggest that XPC gene PAT+/-polymorphism, but not rs2228001, likely contributes to susceptibility to PCa.
authors.affiliation: 1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui, China .
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Qian-Ling
authors.initials: QL
authors.lastname: Ye
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.forename: Hong
authors.initials: H
authors.lastname: Su
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D039781:PubMed; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C086984:XPC protein, human