title: Band specific changes in thalamocortical synchrony in field potentials after cardiac arrest induced global hypoxia.
abstract: Cardiac Arrest (CA) leads to a global hypoxic-ischemic injury in the brain leading to a poor neurological outcome. Understanding the mechanisms of functional disruption in various regions of the brain may be essential for the development of improved diagnostic and therapeutic solutions. Using controlled laboratory experiment with animal models of CA, our primary focus here is on understanding the functional changes in the thalamus and the cortex, associated with the injury and acute recovery upon resuscitation. Specifically, to study the changes in thalamocortical synchrony through these periods, we acquired local field potentials (LFPs) from the ventroposterior lateral (VPL) nucleus of the thalamus and the forelimb somatosensory cortex (S1FL) in rats after asphyxial CA. Band-specific relative Hilbert phases were used to analyze synchrony between the LFPs. We observed that the CA induced global ischemia changes the local phase-relationships by introducing a phase-lag in both the thalamus and the cortex, while the synchrony between the two regions is nearly completely lost after CA.
authors.forename: Anil
authors.initials: A
authors.lastname: Maybhate
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Yama
authors.initials: Y
authors.lastname: Akbari
authors.forename: David L
authors.initials: DL
authors.lastname: Sherman
authors.forename: Kaiquan
authors.initials: K
authors.lastname: Shen
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Jia
authors.forename: Nitish V
authors.initials: NV
authors.lastname: Thakor
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D058407:Electroencephalography Phase Synchronization; D005073:Evoked Potentials, Somatosensory; D005552:Forelimb; D006323:Heart Arrest / Q000503:physiopathology*; D000860:Hypoxia; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology*; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology