title: Data-mining for sulfur and fluorine: an evaluation of pharmaceuticals to reveal opportunities for drug design and discovery.
abstract: Among carbon, hydrogen, oxygen, and nitrogen, sulfur and fluorine are both leading constituents of the pharmaceuticals that comprise our medicinal history. In efforts to stimulate the minds of both the general public and expert scientist, statistics were collected from the trends associated with therapeutics spanning 12 disease categories (a total of 1969 drugs) from our new graphical montage compilation: disease focused pharmaceuticals posters. Each poster is a vibrant display of a collection of pharmaceuticals (including structural image, Food and Drug Administration (FDA) approval date, international nonproprietary name (INN), initial market name, and a color-coded subclass of function) organized chronologically and classified according to an association with a particular clinical indication. Specifically, the evolution and structural diversity of sulfur and the popular integration of fluorine into drugs introduced over the past 50 years are evaluated. The presented qualitative conclusions in this article aim to promote innovative insights into drug development.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona , 1306 E. University Boulevard, Tucson, Arizona 85721, United States.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Ilardi
authors.forename: Edon
authors.initials: E
authors.lastname: Vitaku
authors.forename: Jon T
authors.initials: JT
authors.lastname: Njardarson
mesh_terms: D000818:Animals; D057225:Data Mining; D017277:Drug Approval; D015195:Drug Design; D055808:Drug Discovery; D005069:Evaluation Studies as Topic; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D004364:Pharmaceutical Preparations; D005461:Fluorine; D013455:Sulfur