title: The emerging role of outdoor and indoor air pollution in cardiovascular disease.
abstract: Outdoor and indoor air pollution poses a significant cardiovascular risk, and has been associated with atherosclerosis, the main underlying pathology in many cardiovascular diseases. Although, it is well known that exposure to air pollution causes pulmonary disease, recent studies have shown that cardiovascular health consequences of air pollution generally equal or exceed those due to pulmonary diseases. The objective of this article is to evaluate the current evidence on the emerging role of environmental air pollutions in cardiovascular disease, with specific focus on the types of air pollutants and mechanisms of air pollution-induced cardiotoxicity. Published literature on pollution was systematically reviewed and cited in this article. It is hoped that this review will provide a better understanding of the harmful cardiovascular effects induced by air pollution exposure. This will help to bring a better understanding on the possible preventive health measures and will also serve regulatory agencies and researchers. In addition, elucidating the biological mechanisms underlying the link between air pollution and cardiovascular disease is an essential target in developing novel pharmacological strategies aimed at decreasing adverse effects of air pollution on cardiovascular system.
authors.affiliation: Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, MA, USA.
authors.forename: Jacinta C
authors.initials: JC
authors.lastname: Uzoigwe
authors.forename: Thavaleak
authors.initials: T
authors.lastname: Prum
authors.forename: Eric
authors.initials: E
authors.lastname: Bresnahan
authors.forename: Mahdi
authors.initials: M
authors.lastname: Garelnabi
keywords: Air pollution; Atherosclerosis; Cardiovascular diseases