title: [Adaptation and validation of CAMDEX-DS (Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and others with intellectual disabilities) in Spanish population with intellectual disabilities].
abstract: BACKGROUND
  Dementia caused by Alzheimer's disease commonly affects the adult population with Down's syndrome. This population presents two characteristic clinical features: a semiologic pattern that differs from the typical Alzheimer's disease, and previous intellectual deficits that may confound the clinical diagnosis. There is a clear need to validate specific instruments adapted to Spanish population.
  
  
  OBJECTIVE
  To adapt and to validate CAMDEX-DS (Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities) in Spanish population.
  
  
  METHODS
  146 patients with intellectual disability (mild to moderate) were recruited and assessed with CAMDEX-DS, K-BIT I and DMR tests. Test-retest reliability, inter-rater concordance and validity statistic were performed between CAMDEX-DS and clinical diagnosis. This is an observational, multicenter, cross-sectional and validation study.
  
  
  RESULTS
  Test-retest and inter-rater reliability achieved kappa coefficient values of 0.92 and 0.91, respectively. Agreement (kappa index) for CAMDEX-DS on clinical diagnosis compared to other clinical criteria was high: CAMDEX-DS vs DSM-IV (kappa = 0.95; p < 0,001); CAMDEX-DS vs ICD-10 (kappa = 0.97; p < 0.001). All item-test correlations ranged between 0,31 and 0,69. Internal reliability-calculated using Chronbach's alpha scored 0.93.
  
  
  CONCLUSIONS
  The Spanish version of CAMDEX-DS is a valid instrument with high applicability for people with intellectual disability. It shows good psychometric properties. The Cambridge Cognitive Examination for Older Adults with Down's Syndrome (CAMCOG-DS) can set two key points by the level of intellectual disability on the suspicion of cognitive impairment in people with Down's syndrome.
authors.affiliation: Parc Hospitalari Marti i Julia, 17190 Salt, Espana.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esteba-Castillo
authors.forename: Albert
authors.initials: A
authors.lastname: Dalmau-Bueno
authors.forename: Núria
authors.initials: N
authors.lastname: Ribas-Vidal
authors.forename: Marta
authors.initials: M
authors.lastname: Vilà-Alsina
authors.forename: Ramon
authors.initials: R
authors.lastname: Novell-Alsina
authors.forename: Javier
authors.initials: J
authors.lastname: García-Alba
mesh_terms: D000328:Adult; D000368:Aged / Q000523:psychology*; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000523:psychology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology*; D007361:Intelligence Tests; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011594:Psychometrics; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013030:Spain; D011795:Surveys and Questionnaires; D014175:Translating