title: Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors.
abstract: A series of phosphonate analogues related to perindopril and ramipril were prepared and tested to estimate their ability to inhibit angiotensin converting enzyme. These new synthesized compounds were active ACE inhibitors with a promising activity.
authors.affiliation: Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gomez
authors.forename: Sabine
authors.initials: S
authors.lastname: Berteina-Raboin
authors.forename: Guillaume
authors.initials: G
authors.lastname: De Nanteuil
authors.forename: Gérald
authors.initials: G
authors.lastname: Guillaumet
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D020134:Catalytic Domain; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D062105:Molecular Docking Simulation; D063065:Organophosphonates / Q000737:chemistry*; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry / Q000378:metabolism; D020913:Perindopril / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D017257:Ramipril / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D063065:Organophosphonates; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D017257:Ramipril; D020913:Perindopril
keywords: Angiotensin converting enzyme; Hypertension; Inhibitors; Phosphonate