title: Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems.
abstract: Magnetic nanodevices based on poly[(methacrylic acid)-co-(N-isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.
authors.affiliation: Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR "Demokritos", Aghia Paraskevi Attikis, Athens GR-15310, Greece. leto@chem.demokritos.gr.
authors.forename: Leto-Aikaterini
authors.initials: LA
authors.lastname: Tziveleka
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Bilalis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Chatzipavlidis
authors.forename: Nikos
authors.initials: N
authors.lastname: Boukos
authors.forename: George
authors.initials: G
authors.lastname: Kordas
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003630:Daunorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells / Q000187:drug effects; D060328:Magnetic Phenomena; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013696:Temperature
chemical_list: D000178:Acrylamides; D011109:Polymethacrylic Acids; C085085:poly(N-isopropylacrylamide-co-methacrylic acid); D003630:Daunorubicin
keywords: drug delivery systems; magnetic polymers; nanocontainers; pH response; temperature response