title: The challenge of stroke prevention with intracranial arterial stenosis.
abstract: Patients with symptomatic intracranial atherosclerotic disease have a high risk of recurrent stroke, and secondary prevention in these patients remains a challenge. Aggressive medical management of vascular risk factors is safe and effective for most high risk patients, but the role of endovascular and surgical therapies still remain uncertain. Future studies may identify novel therapeutic strategies for patients with intracranial atherosclerotic disease, but aggressive risk factor control remains the mainstay of evidenced-based treatment at this time.
authors.affiliation: MUSC Stroke Program, Suite 501, Harborview Office Tower, 19 Hagood Ave, Charleston, SC, 29425, USA, turan@musc.edu.
authors.forename: Tanya N
authors.initials: TN
authors.lastname: Turan
authors.forename: Alison
authors.initials: A
authors.lastname: Smock
authors.forename: Marc I
authors.initials: MI
authors.lastname: Chimowitz
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D017536:Carotid Artery, Common / Q000601:surgery*; D016893:Carotid Stenosis / Q000453:epidemiology / Q000628:therapy*; D000077144:Clopidogrel; D003251:Constriction, Pathologic; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D040242:Risk Reduction Behavior; D055502:Secondary Prevention; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin