title: Deep brain stimulation in addiction due to psychoactive substance use.
abstract: Addiction is one of the most challenging health problems. It is associated with enormous individual distress and tremendous socioeconomic consequences. Unfortunately, its underlying mechanisms are not fully understood, and pharmacological, psychological, or social interventions often fail to achieve long-lasting remission. Next to genetic, social, and contextual factors, a substance-induced dysfunction of the brain's reward system is considered a decisive factor for the establishment and maintenance of addiction. Due to its successful application and approval for several neurological disorders, deep brain stimulation (DBS) is known as a powerful tool for modulating dysregulated networks and has also been considered for substance addiction. Initial promising case reports of DBS in alcohol and heroin addiction in humans have recently been published. Likewise, results from animal studies mimicking different kinds of substance addiction point in a similar direction. The objective of this review is to provide an overview of the published results on DBS in addiction, and to discuss whether these preliminary results justify further research, given the novelty of this treatment approach.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany. Electronic address: jens.kuhn@uk-koeln.de.
authors.forename: Jens
authors.initials: J
authors.lastname: Kuhn
authors.forename: Christian P
authors.initials: CP
authors.lastname: Bührle
authors.forename: Doris
authors.initials: D
authors.lastname: Lenartz
authors.forename: Volker
authors.initials: V
authors.lastname: Sturm
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000209:etiology* / Q000628:therapy*
chemical_list: D011619:Psychotropic Drugs
keywords: addiction; alcohol; animal model; deep brain stimulation; heroin; neuromodulation; nucleus accumbens