title: Non-structural proteins of arthropod-borne bunyaviruses: roles and functions.
abstract: Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.
authors.affiliation: Department of Botany and Microbiology, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. anne-lie.blomstrom@slu.se.
authors.forename: Saleh
authors.initials: S
authors.lastname: Eifan
authors.forename: Esther
authors.initials: E
authors.lastname: Schnettler
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dietrich
authors.forename: Alain
authors.initials: A
authors.lastname: Kohl
authors.forename: Anne-Lie
authors.initials: AL
authors.lastname: Blomström
mesh_terms: D000818:Animals; D001103:Arboviruses / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D001181:Arthropods / Q000821:virology*; D002043:Bunyaviridae / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D010944:Plants; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D017361:Viral Nonstructural Proteins