title: Visible-light-induced trifluoromethylation of N-aryl acrylamides: a convenient and effective method to synthesize CF(3)-containing oxindoles bearing a quaternary carbon center.
abstract: Trifluoromethylation/arylation: N-aryl acrylamides undergo visible-light-induced tandem trifluoromethylation/arylation in the presence of a ruthenium photocatalyst with Togni's reagent as the CF3 source. This reaction serves as a powerful and ecofriendly synthetic method for the preparation of a variety of CF3 -containing oxindoles bearing a quaternary carbon center.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 (P.R. China), Fax: (+86) 25-83594886.
authors.forename: Pan
authors.initials: P
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
authors.forename: Qicai
authors.initials: Q
authors.lastname: Xue
authors.forename: Changduo
authors.initials: C
authors.lastname: Pan
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Cheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zhu
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D008745:Methylation; D009861:Onium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D000078183:Oxindoles
chemical_list: D000178:Acrylamides; D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D009861:Onium Compounds; D000078183:Oxindoles; C022960:2-oxindole
keywords: alkenes; photocatalysis; radical addition; synthetic methods; trifluoromethylation