title: In vitro anti-Candida activity of certain new 3-(1H-imidazol-1-yl)propan-1-one oxime esters.
abstract: Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. mattia@ksu.edu.sa.
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Attia
authors.forename: Azza S
authors.initials: AS
authors.lastname: Zakaria
authors.forename: Maha S
authors.initials: MS
authors.lastname: Almutairi
authors.forename: Soraya W
authors.initials: SW
authors.lastname: Ghoneim
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D041022:Candida tropicalis / Q000187:drug effects*; D004952:Esters; D015725:Fluconazole / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D004952:Esters; D007093:Imidazoles; D010091:Oximes; D008825:Miconazole; D015725:Fluconazole