title: Association of intercellular adhesion molecular-1 gene polymorphism in ischemic stroke patients.
abstract: BACKGROUND
  Ischemic stroke (IS) is a prevalent disease causing a body disability, the third leading cause of death in Taiwan. It shows that the level of intercellular adhesion molecular-1 (ICAM-1) in IS patients is higher than control subjects.
  
  
  OBJECTIVE
  This study is to investigate the possible association of ICAM-1 (G1548A) polymorphism in IS patients.
  
  
  METHODS
  A total of 646 subjects were enrolled in this study, including 312 IS patients, and 334 controls without a history of symptomatic IS. The ICAM-1 (G1548A) polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism. Clinical factors were also determined.
  
  
  RESULTS
  The frequencies of the ICAM-1 (G1548A) polymorphism for G/G, G/A, and A/A were 74.8%, 23.9%, and 0.3%, respectively, in healthy controls, and 62.8%, 32.1%, and 5.1%, respectively, in patients. The frequency of the ICAM-1 (G1548A) A allele (21.2% versus 13.2%, respectively; P = 0.007) and the carriers of the ICAM-1 (G1548A) A allele (37.2% versus 25.2%; P = 0.019, OR 1.76, 95% CI 1.1-2.83) are great in IS patients compared with healthy controls. There is a higher risk of IS associated with homozygosity for the ICAM-1 (G1548A) A allele (AA genotype) compared with the control population (5.1% vs. 0.3%, respectively, P = 0.04; OR 5.1, 95% CI 1.19-21.66). We also observed both hypertension and diabetes has shown a positive association with IS.
  
  
  CONCLUSIONS
  The ICAM-1 (G1548A) polymorphism was associated with independent risk factor for the development of IS.
authors.affiliation: Department of Professional Medicine, Neurosurgery Division, Kaohsiung Armed Forces General Hospital, VAC, EY, Taiwan.
authors.forename: Ching-Hsiang
authors.initials: CH
authors.lastname: Lu
authors.forename: Chiao-Wen
authors.initials: CW
authors.lastname: Hwang
authors.forename: Nan-Fu
authors.initials: NF
authors.lastname: Chen
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Liu
authors.forename: Wen-Tung
authors.initials: WT
authors.lastname: Wu
keywords: Allele; intercellular adhesion molecular-1; ischemic stroke; polymorphism