title: Primary care patient willingness for genetic testing for salt-sensitive hypertension: a cross sectional study.
abstract: BACKGROUND
  The current research into single nucleotide polymorphisms has extended the role of genetic testing to the identification of increased risk for common medical conditions. Advances in genetic research may soon necessitate preparation for the role of genetic testing in primary care medicine. This study attempts to determine what proportion of patients would be willing to undergo genetic testing for salt-sensitive hypertension in a primary care setting, and what factors are related to this willingness.
  
  
  METHODS
  A cross-sectional study using a self-report questionnaire was conducted among outpatients in primary care clinics and hospitals in Japan. The main characteristics measured were education level, family medical history, personal medical history, concern about hypertension, salt preference, reducing salt intake, and willingness to undergo genetic testing for salt-sensitive hypertension.
  
  
  RESULTS
  Of 1,932 potential participants, 1,457 (75%) responded to the survey. Of the respondents, 726 (50%) indicated a willingness to undergo genetic testing. Factors related to this willingness were being over 50 years old (adjusted odds ratio [ad-OR] = 1.42, 95% Confidence interval = 1.09 - 1.85), having a high level of education (ad-OR: 1.83, 1.38 - 2.42), having a family history of hypertension (ad-OR: 1.36, 1.09 - 1.71), and worrying about hypertension (ad-OR: 2.06, 1.59 - 2.68).
  
  
  CONCLUSIONS
  Half of the primary care outpatients surveyed in this study wanted to know their genetic risk for salt-sensitive hypertension. Those who were worried about hypertension or had a family history of hypertension were more likely to be interested in getting tested. These findings suggest that primary care physicians should provide patients with advice on genetic testing, as well as address their anxieties and concerns related to developing hypertension.
authors.affiliation: Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Yakushiji 3311-1, Shimotsuke-city, Tochigi 329-0498, Japan. okayama@jichi.ac.jp.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Okayama
authors.forename: Taro
authors.initials: T
authors.lastname: Takeshima
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Ae
authors.forename: Masanori
authors.initials: M
authors.lastname: Harada
authors.forename: Eiji
authors.initials: E
authors.lastname: Kajii
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001294:Attitude to Health; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D020022:Genetic Predisposition to Disease / Q000523:psychology; D005820:Genetic Testing / Q000706:statistics & numerical data*; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000523:psychology*; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D011320:Primary Health Care; D011795:Surveys and Questionnaires