title: Hematologic reference intervals in Cynomolgus (Macaca fascicularis) monkeys.
abstract: BACKGROUND
  Reference intervals are important aids for interpreting clinical pathology laboratory data especially in Cynomolgus monkey (Macaca fascicularis), the non-human primate species most widely used in biomedical research. The purpose of this study was to establish hematologic reference intervals for Cynomolgus according to the International Federation of Clinical Chemistry and Clinical and Laboratory Standards Institute guidelines using the databank at a primatology center.
  
  
  METHODS
  Blood specimens from 272 healthy Cynomolgus imported from Mauritius, the Philippines and Vietnam, were analyzed. Reference intervals were established by nonparametric method. Effects of sex, age, body weight, and breeding origin were investigated.
  
  
  RESULTS
  Hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration decreased slightly and mean corpuscular volume increased slightly with age. Lower red blood cell concentration, hemoglobin, and hematocrit were observed in monkeys from the Philippines.
  
  
  CONCLUSIONS
  These hematology reference intervals, established according to international recommendations, can be used in settings using similar animals and analyzers.
authors.affiliation: Université de Toulouse, INP, ENVT, Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Bourgès-Abella
authors.forename: A
authors.initials: A
authors.lastname: Geffré
authors.forename: E
authors.initials: E
authors.lastname: Moureaux
authors.forename: M
authors.initials: M
authors.lastname: Vincenti
authors.forename: J P
authors.initials: JP
authors.lastname: Braun
authors.forename: C
authors.initials: C
authors.lastname: Trumel
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005260:Female; D005843:Geography; D006403:Hematologic Tests; D008252:Macaca fascicularis / Q000097:blood* / Q000235:genetics; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics
keywords: a posteriori determination; blood; non-human primates; reference values