title: Tetherin upregulation in simian immunodeficiency virus-infected macaques.
abstract: Here we show that simian immunodeficiency virus (SIV) infection of rhesus macaques results in rapid upregulation of tetherin (BST-2 or CD317) on peripheral blood lymphocytes, including the CD4(+) CCR5(+) T cell targets of virus infection, with a peak of induction that coincides with peak alpha interferon (IFN-α) levels in plasma, and that tetherin remains above baseline levels throughout chronic infection. These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Rahmberg
authors.forename: William J
authors.initials: WJ
authors.lastname: Neidermyer
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Breed
authors.forename: Xavier
authors.initials: X
authors.lastname: Alvarez
authors.forename: Cecily C
authors.initials: CC
authors.lastname: Midkiff
authors.forename: Michael
authors.initials: M
authors.lastname: Piatak
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lifson
authors.forename: David T
authors.initials: DT
authors.lastname: Evans
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD