title: Absence of intraocular infections after hematopoietic stem cell transplantation at a single center: the experience with current preventive regimens.
abstract: OBJECTIVE
  To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT).
  
  
  METHODS
  The study design was a single institutional retrospective noncomparative cohort of 135 consecutive patients in 2006 and 2007 who underwent allo-SCT for hematological malignancy. The primary outcome was the development of intraocular infections after allo-SCT and secondary outcome consisted of development of other ocular disorders during follow-up.
  
  
  RESULTS
  The most frequent ocular sequel to allo-SCT included ocular graft-versus-host disease (GvHD), which developed in 37/135 patients (27%). Intraocular infection occurred in 1 of 135 patients (0.7%). This patient developed infectious chorioretinitis together with osteomyelitis, endocarditis, and brain abscess with fungus Scedosporium and was successfully treated with a combination of voriconazole, amphotericine B, and surgical interventions. Viral and/or bacterial intraocular infections were not observed at all.
  
  
  CONCLUSIONS
  Intraocular infections after allo-SCT are currently uncommon due to systematic use of preemptive treatment regimens, frequent controls, and early treatment of systemic infections.
authors.affiliation: Department of Ophthalmology .
authors.forename: Elena I
authors.initials: EI
authors.lastname: Stoyanova
authors.forename: Anjo
authors.initials: A
authors.lastname: Riemens
authors.forename: Henk M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: Liane
authors.initials: L
authors.lastname: te Boome
authors.forename: Aniki
authors.initials: A
authors.lastname: Rothova
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D015817:Eye Infections / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D013997:Time Factors; D055815:Young Adult