title: Synthesis, antimicrobial evaluation and QSAR studies of 2-hydroxy propanoic acid derivatives.
abstract: A series of 2-hydroxypropanoic acid derivatives (1-26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier's valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.
authors.affiliation: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
authors.forename: A
authors.initials: A
authors.lastname: Bansal
authors.affiliation: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
authors.forename: B
authors.initials: B
authors.lastname: Narasimhan
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D011422:Propionates