title: Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung.
abstract: The prognosis is poor for patients with advanced pleomorphic carcinoma of the lung due to the generally limited response to chemotherapy and/or radiotherapy. It has been suggested the production of granulocyte colony-stimulating factor (G-CSF) by cancer cells may aggravate the disease progression. We herein report a case of a 73-year-old Japanese man with advanced G-CSF-producing pleomorphic carcinoma of the lung. First-line chemotherapy with carboplatin and paclitaxel had been suspended. Subsequent radiotherapy achieved a moderate volume reduction and an amelioration of the excessive G-CSF-related complications. Six cycles of second-line chemotherapy with docetaxel administered with good results. These combined treatments resulted in long term survival without progression of the disease.
authors.affiliation: Respiratory Medicine, Yokohama City University Hospital, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Saki
authors.initials: S
authors.lastname: Manabe
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Moriyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Shintetsu
authors.initials: S
authors.lastname: Tanaka
authors.forename: Ryohei
authors.initials: R
authors.lastname: Takahashi
authors.forename: Koji
authors.initials: K
authors.lastname: Tomaru
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Kudo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002277:Carcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D012074:Remission Induction; D013997:Time Factors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor