title: Matrix metalloproteinase-9 expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in young adult patients with classical Hodgkin lymphoma.
abstract: Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma.
authors.affiliation: Department of Anatomic Pathology, A C Camargo Cancer Care Center, São Paulo, SP, Brazil.
authors.forename: Antonio Hugo
authors.initials: AH
authors.lastname: Campos
authors.forename: Jose
authors.initials: J
authors.lastname: Vassallo
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Soares
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology; D006689:Hodgkin Disease / Q000201:enzymology* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D016539:Reed-Sternberg Cells / Q000201:enzymology* / Q000473:pathology* / Q000821:virology; D016019:Survival Analysis; D055815:Young Adult
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9