title: Bisphosphine-triggered one-pot sequential [3 + 2]/[3 + 2] annulation of allenoates with cyclic ketimines.
abstract: An efficient bisphosphine-triggered one-pot sequential [3 + 2]/[3 + 2] annulation of allenoates with cyclic ketimines was developed, in which the product of the first [3 + 2] annulation is the electron-deficient substrate for the second [3 + 2] annulation reaction. The reaction is exceptionally regioselective and diastereoselective. This novel and highly convergent strategy may open up a new viewpoint in utilizing allenoates to prepare N-fused polycyclic compounds.
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), State Synergetic Innovation Center of Chemical Science and Engineering, Tianjin University , Tianjin 300072, P. R. of China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Yang
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D003500:Cyclization; D004952:Esters / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D004952:Esters; D007097:Imines; D009570:Nitriles; D010720:Phosphines; D011083:Polycyclic Compounds; C542835:ketimine; C044646:phosphine