title: Efficacy of a piglet-specific commercial inactivated vaccine against Porcine circovirus type 2 in clinical field trials.
abstract: The efficacy of a piglet-specific inactivated Porcine circovirus type 2 (PCV2) vaccine was evaluated with clinical field trials, as recommended by the Republic of Korea's Animal, Plant & Fisheries Quarantine & Inspection Agency. Three farms were selected on the basis of their history of postweaning multisystemic wasting syndrome. On each farm 60, 1-week-old pigs were randomly allocated to 1 of 2 treatment groups: vaccination at 1 and 3 wk of age or no vaccination. The 2-dose schedule of vaccination with inactivated PCV2 vaccine improved the average daily weight gain from birth to 16 wk of age, the PCV2 load in the blood, and the frequency and severity of lymph node lesions. Inactivated PCV2 vaccine seems to be very effective in controlling PCV2 infection under field conditions.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea (Han, Seo, Oh, Park, Kang, Chae); Komipharm International Company Ltd., 1Ra-107 Shiwha Industrial Complex, Shiheung-shi, Kyongki-do, Republic of Korea (Jang).
authors.forename: Kiwon
authors.initials: K
authors.lastname: Han
authors.forename: Hwi Won
authors.initials: HW
authors.lastname: Seo
authors.forename: Yeonsu
authors.initials: Y
authors.lastname: Oh
authors.forename: Changhoon
authors.initials: C
authors.lastname: Park
authors.forename: Ikjae
authors.initials: I
authors.lastname: Kang
authors.forename: Hyun
authors.initials: H
authors.lastname: Jang
authors.forename: Chanhee
authors.initials: C
authors.lastname: Chae
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001835:Body Weight / Q000276:immunology; D017925:Circovirus / Q000235:genetics / Q000276:immunology*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D053570:Porcine Postweaning Multisystemic Wasting Syndrome / Q000097:blood / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D056910:Republic of Korea; D013552:Swine; D014611:Vaccination / Q000379:methods / Q000592:standards / Q000662:veterinary*; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines