title: Model-based measurement of gas exchange in healthy subjects using ALPE essential--influence of age, posture and gender.
abstract: The ALPE Essential device for model-based measurement of pulmonary gas exchange status may be a useful alternative to current methods for diagnosing, monitoring and evaluating treatment related to pulmonary gas exchange. In this study, shunt and ventilation/perfusion mismatch were measured with ALPE Essential in 106 healthy subjects with the aim of investigating the influence of age, posture and gender on gas exchange parameters and evaluating the test-retest reliability of the measurements. Age and gender did not have statistically significant influence on gas exchange parameters, although there was a tendency for poorer matching of ventilation and perfusion with age. Posture was shown to be important when measuring gas exchange parameters. Absolute measurement reliability was acceptable with future studies in patients being necessary for accurate evaluation of relative reliability.
authors.forename: Dan S
authors.initials: DS
authors.lastname: Karbing
authors.forename: Lars P
authors.initials: LP
authors.lastname: Thomsen
authors.forename: J
authors.initials: J
authors.lastname: Moesgaard
authors.forename: Steen
authors.initials: S
authors.lastname: Andreassen
authors.forename: Egon
authors.initials: E
authors.lastname: Toft
authors.forename: Per
authors.initials: P
authors.lastname: Thorgaard
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Rees
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011187:Posture; D011659:Pulmonary Gas Exchange; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D012737:Sex Factors; D055815:Young Adult