title: Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome.
abstract: Iridocorneal endothelial (ICE) syndrome is a primary endothelial abnormality that can cause a spectrum of iris changes, corneal edema, and glaucoma. Glaucoma secondary to ICE is difficult to manage because of the inflammatory reaction and fibrosis it can cause. We present a case of postoperative fibrinous reaction following endoscopic cyclophotocoagulation in ICE that caused aqueous tube shunt occlusion and high intraocular pressure. The condition was successfully managed with tissue plasminogen activator.
authors.affiliation: Department of Ophthalmology, Division of Glaucoma, Doheny Eye Institute, Keck School of Medicine, University of Southern California.
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Hong
authors.forename: Brian A
authors.initials: BA
authors.lastname: Francis
mesh_terms: D000867:Anterior Chamber; D002387:Cataract Extraction / Q000009:adverse effects; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D056965:Injections, Intraocular; D057129:Iridocorneal Endothelial Syndrome / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000009:adverse effects; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator