title: Expression of protease-activated receptor-2 in human gastric stromal tumor and its clinicopathological significance.
abstract: OBJECTIVE
  To explore the expression of protein-activated receptor-2 (PAR-2) in human gastric stromal tumor and its clinicopathological significance.
  
  
  METHODS
  The expression of PAR-2 was detected with immunohistochemisty, RT-PCR and Western blot in tumor tissue, peritumoral tissue and gastric normal tissue from 72 patients with gastric stromal tumor.
  
  
  RESULTS
  PAR-2 expression was significantly higher in peritumoral tissue (p < 0.05) and tumor tissue (p < 0.01) than in gastric normal tissue, and significantly higher in tumor tissue than in peritumoral tissue (p < 0.01). With the increase in NIH grade, PAR-2 expression was elevated in tumor tissues. PAR-2 expression was strongly associated with mucosal invasion.
  
  
  CONCLUSIONS
  PAR-2 expression is significantly higher in gastric stromal tumor tissue than in peritumoral tissue and gastric normal tissue. The high expression of PAR-2 may be associated with the invasion and metastasis of gastric stromal tumor.
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Wang
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Wang
authors.forename: Di-Nuo
authors.initials: DN
authors.lastname: Li
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D015153:Blotting, Western; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry* / Q000235:genetics / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D012333:RNA, Messenger / Q000032:analysis; D044464:Receptor, PAR-2 / Q000032:analysis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D044464:Receptor, PAR-2