title: Association of interleukin-33 gene single nucleotide polymorphisms with ischemic stroke in north Chinese population.
abstract: BACKGROUND
  IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in the development of atherosclerosis, genetic influences of the polymorphisms of IL33 in human ischemic stroke are unclear. The aim of this study was to examine whether the single nucleotide polymorphisms in IL33 are associated with ischemic stroke in Northern Chinese population.
  
  
  METHODS
  We used a nested case-control study involving 90 ischemic stroke patients and 270 age-matched, sex-matched and blood pressure-matched non-ischemic stroke controls from a rural population and determined the genotypes of four polymorphisms (rs1929992, rs10975519, rs4742170, rs16924159) in IL33 by Snapshot SNP genotyping assays to assess any links with ischemic stroke.
  
  
  RESULTS
  Univariate analysis showed two single nucleotide polymorphisms (rs1929992, rs4742170) in IL33 were associated with ischemic stroke in additive, dominant, and recessive model. Binary Logistic Regression shows that rs4742170 variation is the most important factor associated with ischemic stroke (adjusted odds ratio (OR) = 1.880, 95% confidence interval (CI) = 1.316-2.686 in an additive model; OR = 2.091, CI = 1.249-3.498 in a dominant model; OR = 2.623, CI = 1.366-5.036 in a recessive model).
  
  
  CONCLUSIONS
  In this sample of patients, genetic variation of rs4742170 in IL33 is significantly associated with the developing of ischemic stroke.
authors.affiliation: Department of Cardiology, the First Hospital of China Medical University, Shenyang 110001, China. sunyingxian12@126.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.forename: Xinghu
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Guo
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000235:genetics*; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins