title: Primary pineal glioblastoma: a case report.
abstract: Glioblastoma is very rare in the pineal region. We report a case of glioblastoma in this region. This is the 18th case of primary glioblastoma in the pineal region and the second case that survived over two years according the literature. A 60-year-old man admitted with headache and ataxia that continued for the last 3 months. Physical examination was normal. Neurological examination revealed ataxia. There was no motor or sensory deficit. Computer tomography showed triventricular hydrocephalus and isodense rounded mass in the pineal region. Magnetic resonance images revealed a regular-edged heterogeneous contrast-enhanced tumor in pineal region. A ventriculoperitoneal shunt was inserted for hydrocephalus. After surgery, the ataxia and hydrocephalus were improved. Ten days later, serial stereotactic biopsies were performed. Histopathological specimens revealed glioblastoma. The patient was recommended to undergo radiotherapy and chemotherapy. The patient is still surviving without deficit two years after biopsy and shunt operation.
authors.affiliation: Ankara University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Ozgural
authors.forename: Gokmen
authors.initials: G
authors.lastname: Kahilogullari
authors.forename: Melih
authors.initials: M
authors.lastname: Bozkurt
authors.forename: Aylin Okcu
authors.initials: AO
authors.lastname: Heper
authors.forename: Ali
authors.initials: A
authors.lastname: Savas
mesh_terms: D001259:Ataxia / Q000209:etiology; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy*; D006261:Headache / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010871:Pinealoma / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D017287:Ventriculoperitoneal Shunt
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016159:Tumor Suppressor Protein p53