title: Synaptic vesicle protein 2A: basic facts and role in synaptic function.
abstract: In recent years, there has been considerable interest in determining the function of synaptic vesicle protein 2A and its role as a target for antiepileptic drugs. Although it is known that synaptic vesicle protein 2A is involved in normal synaptic vesicle function, its participation in synaptic vesicle cycling and neurotransmitter release in normal and pathological conditions is unclear. However, the experimental evidence suggests that synaptic vesicle protein 2A could be a vesicular transporter, regulate synaptic exocytosis as a gel matrix, or modulate synaptotagmin-1 activity. This review describes and discusses the participation of synaptic vesicle protein 2A in synaptic modulation in normal and pathological conditions.
authors.affiliation: Neurochemistry Laboratory, Instituto Nacional de Pediatría, D. F., Mexico.
authors.forename: Julieta Griselda
authors.initials: JG
authors.lastname: Mendoza-Torreblanca
authors.forename: América
authors.initials: A
authors.lastname: Vanoye-Carlo
authors.forename: Bryan Víctor
authors.initials: BV
authors.lastname: Phillips-Farfán
authors.forename: Liliana
authors.initials: L
authors.lastname: Carmona-Aparicio
authors.forename: Gisela
authors.initials: G
authors.lastname: Gómez-Lira
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism* / Q000502:physiology; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C076414:SV2A protein, human
keywords: epilepsy; neurotransmitter; neurotransmitter release; synapse; synaptic proteins