title: [Treatment of severe and uncomplicated falciparum malaria in children in France].
abstract: Quinine was the main treatment for malaria between 1630 and the beginning of the XXth century. In the 1940s, the synthesis of chloroquine gave rise to the hope of eliminating this plague. Falciparum resistance to chloroquine, first observed in Asia then in sub-Saharan Africa, lead researchers to discover halofantrine, mefloquine, atovaquone-proguanil and artemisinin combined therapies. There is no ideal treatment for uncomplicated imported malaria in children. Medical teams have to develop a protocol according to available drugs and their personal experience, with a special attention to follow-up at days 3-4 and day 28. From now on, severe malaria must be treated with intravenous artesunate, a more effective therapy than quinine.
authors.affiliation: Service d'accueil des urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France. Electronic address: lauren.pull@rdb.aphp.fr.
authors.forename: L
authors.initials: L
authors.lastname: Pull
authors.affiliation: Service d'accueil des urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: Bellettre
authors.affiliation: Service d'accueil des urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Michel
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital Avicenne, AP-HP, 125, rue de Stalingrad, 93000 Bobigny, France.
authors.forename: O
authors.initials: O
authors.lastname: Bouchaud
authors.affiliation: Service d'accueil des urgences pédiatriques, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: J Y
authors.initials: JY
authors.lastname: Siriez
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins / Q000627:therapeutic use; D000077332:Artesunate; D053626:Atovaquone / Q000627:therapeutic use; D002648:Child; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D005602:France; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology; D002727:Proguanil / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use; D010879:Piperazines
chemical_list: D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D000077332:Artesunate; D053626:Atovaquone; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D002727:Proguanil; D011804:Quinolines; C109496:atovaquone, proguanil drug combination; C039060:artenimol; C034759:piperaquine; D010879:Piperazines