title: Kruppel-like factor 2 regulates dendritic cell activation in patients with acute coronary syndrome.
abstract: OBJECTIVE
  Dendritic cells (DCs) activation is important in atherosclerosis and coronary heart disease, but the mechanisms regulating activation of dendritic cells remain largely unclear. The aim of this study was to evaluate the effect of transcription factor Kruppel-like factor 2 (KLF2) in the proinflammatory activation of DCs in acute coronary syndrome.
  
  
  RESULTS
  In this study, the expression of CD80 and KLF2 was detected in DCs in normal health controls, patients with stable angina (SA), and acute coronary syndrome (ACS). Our study found that compared with normal control and SA, KLF2 expression in DCs is reduced in patients with ACS. Moreover, the surface expression of CD80 was increased in ACS. In vitro experiment, we found that ox-LDL could increase CD80 expression and decrease KLF2 expression. Furthermore, down-regulated KLF2 could in turn increase CD80 expression via NF-κB pathway.
  
  
  CONCLUSIONS
  These observations identify KLF2 as a novel negative regulator of DC function and it may play an essential role in DC activation in ACS.
authors.affiliation: Department of Cardiology, Shenzhen Sixth People's Hospital (Nanshan Hospital), Huazhong University of Science and Technology, Union Shenzhen Hospital, Shenzhen, China.
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Fang
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Peiyi
authors.initials: P
authors.lastname: Xie
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Jianyun
authors.initials: J
authors.lastname: Fu
authors.forename: Wen
authors.initials: W
authors.lastname: Ai
authors.forename: Shaoyuan
authors.initials: S
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Fengxiao
authors.initials: F
authors.lastname: Zhang
authors.forename: Yousu
authors.initials: Y
authors.lastname: Su
authors.forename: Dazhu
authors.initials: D
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D018122:B7-1 Antigen / Q000378:metabolism; D015153:Blotting, Western; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000378:metabolism*; D024202:Electrophoretic Mobility Shift Assay; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction
chemical_list: D018122:B7-1 Antigen; C096161:KLF2 protein, human; D051741:Kruppel-Like Transcription Factors; D016328:NF-kappa B