title: Drug-induced liver injury from antiepileptic drugs.
abstract: Drug-induced liver injury is a potential complication of innumerable medications. Most cases do not occur in a predictable, dose-dependent manner, leading to delayed recognition of a drug's hepatotoxic potential until after its release into the market. The estimated occurrence is 1 in 10,000 to 100,000 patients. However, the rates are likely higher because many cases go unrecognized owing to lack of reporting or missed diagnosis. This article reviews the most commonly associated antiepileptic drugs.
authors.affiliation: Division of Gastroenterology/Hepatology, Scripps Clinic, and Scripps Translational Science Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Au
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Pockros
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans
chemical_list: D000927:Anticonvulsants
keywords: Antiepileptic drugs; Drug-induced liver injury; Hepatotoxicity