title: Hepatotoxicity of antibiotics: a review and update for the clinician.
abstract: Collectively, the various classes of antibiotics are a leading cause of drug-induced liver injury (DILI). However, acute antibiotic-associated DILI can be difficult to diagnose, as the course of therapy is usually brief, and other confounding factors are often present. In addition to the broad clinicopathologic spectrum of hepatotoxicity associated with the antimicrobials, the underlying infectious disease being treated may itself be associated with hepatic dysfunction and jaundice. This review provides summarized information on several classes of antimicrobial agents, highlighting new agents causing DILI and updating information on older agents.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Georgetown University Medical Center, 3800 Reservoir Road, NW Room M2408, Washington, DC 20007, USA.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Stine
authors.forename: James H
authors.initials: JH
authors.lastname: Lewis
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans
chemical_list: D000890:Anti-Infective Agents
keywords: Antibiotics; Drug safety; Drug-induced liver injury; Monitoring