title: Zooming in on eukaryotic translation initiation.
abstract: Translation initiation in eukaryotes is a complex and highly regulated process during which several initiation factors cooperate to recruit an initiator tRNA to the small ribosomal subunit, where the mRNA is scanned for an AUG start codon. Two recent reports provide new structural insights into this process and reveal key functions of initiation factors 1 (eIF1) and 1A (eIF1A) in start-codon selection in atomic detail.
authors.affiliation: Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Liljas
mesh_terms: D000818:Animals; D039642:Eukaryotic Initiation Factors / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry*; D014176:Protein Biosynthesis; D011487:Protein Conformation; D012333:RNA, Messenger / Q000737:chemistry* / Q000378:metabolism*; D054682:Ribosome Subunits, Small, Eukaryotic / Q000737:chemistry*; D016808:Tetrahymena thermophila / Q000737:chemistry*
chemical_list: D039642:Eukaryotic Initiation Factors; D046912:Multiprotein Complexes; D012333:RNA, Messenger