title: A report on the first outbreak of a single clone group A Streptococcus (emm-type 89) tonsillopharyngitis in China.
abstract: In 2012, 28 out of 140 staff working for a film crew in a Beijing movie and television base experienced a sudden onset of fever, sore throat, and/or tiredness, headache within the 24 hour period of July 26-27. All of the patients visited the hospital and were diagnosed as having tonsillopharyngitis. On July 28, 2012, a team of Centers for Disease Control and Prevention staff arrived and initiated an outbreak investigation. Pharyngeal swabs were obtained from patients for microbiologic analysis. All isolates of the outbreak were analyzed for toxin-genes and drug-resistance genes by polymerase chain reaction, and were performed for the emm typing and pulsed-field gel electrophoresis typing. On July 30, 2012, Group A Streptococcus was isolated from eight of the 16 throat swab specimens obtained on site. These isolates were found to have the same genotype emm 89. This is the first report to identify Group A Streptococcus emm type-89 as a cause of tonsillopharyngitis in Beijing, China.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Ying-Mei
authors.initials: YM
authors.lastname: Liu
authors.affiliation: Center for Disease Control and Prevention, Fengtai, Beijing, People's Republic of China.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Zhao
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Li
authors.affiliation: Center for Disease Control and Prevention, Fengtai, Beijing, People's Republic of China.
authors.forename: Jun-Yong
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Center for Disease Control and Prevention, Fengtai, Beijing, People's Republic of China.
authors.forename: Xiao-Gen
authors.initials: XG
authors.lastname: Dong
authors.affiliation: Center for Disease Control and Prevention, Fengtai, Beijing, People's Republic of China. Electronic address: ft8302@yahoo.com.cn.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address: caobin1999@gmail.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Cao
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006801:Humans; D058889:Molecular Typing; D010612:Pharyngitis / Q000453:epidemiology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014069:Tonsillitis / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein
keywords: Film crew; Group A Streptococcus; Outbreak; Tonsillopharyngitis; emm-type 89