title: High-frequency spectral changes in Dorsolateral Prefrontal Cortex for potential neuoroprosthetics.
abstract: Dorsolateral Prefrontal Cortex (DLPFC) has been associated with goal encoding in primates. Thus far, the majority of research involving DLPFC, including all electrophysiology studies, has been performed in non-human primates. In this paper, we explore the possibility of utilizing the cortical activity in DLPFC in humans for use in Brain-Computer Interfaces (BCIs). Electrocorticographic signals were recorded from seven patients with intractable epilepsy who had electrode coverage over DLPFC. These subjects performed a visuomotor target-based task to assess DLPFC's involvement in planning, execution, and accomplishment of the simple motor task. These findings demonstrate that there is a distinct high-frequency spectral component in DLPFC associated with accomplishment of the task. It is envisioned that these signals could potentially provide a novel verification of task accomplishment for a BCI.
authors.forename: N R
authors.initials: NR
authors.lastname: Anderson
authors.forename: T
authors.initials: T
authors.lastname: Blakely
authors.forename: P
authors.initials: P
authors.lastname: Brunner
authors.forename: D J
authors.initials: DJ
authors.lastname: Krusienski
authors.forename: D W
authors.initials: DW
authors.lastname: Moran
authors.forename: E C
authors.initials: EC
authors.lastname: Leuthardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D004566:Electrodes; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058117:Neural Prostheses; D017397:Prefrontal Cortex / Q000503:physiopathology*; D013647:Task Performance and Analysis; D055815:Young Adult