title: Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly patient receiving a suboptimal dose of antiviral prophylaxis.
abstract: We report the emergence of an influenza virus A/H3N2-E119V neuraminidase variant from an elderly patient with renal dysfunction who received a suboptimal dose of oseltamivir prophylaxis. In neuraminidase inhibition assays, the E119V variant showed a 413-fold increase in the 50% inhibitory oseltamivir concentration and grew at titers comparable to those of the wild type in vitro.
authors.affiliation: Research Center in Infectious Diseases, Centre Hospitalier Universitaire of Québec, and Laval University, Québec City, Québec, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Roussy
authors.forename: Yacine
authors.initials: Y
authors.lastname: Abed
authors.forename: Xavier
authors.initials: X
authors.lastname: Bouhy
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods*; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification*; D007251:Influenza, Human / Q000517:prevention & control* / Q000821:virology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D009439:Neuraminidase / Q000235:genetics; D053139:Oseltamivir / Q000627:therapeutic use*; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D019562:Viral Load; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins; D053139:Oseltamivir; C487630:NA protein, influenza A virus; D009439:Neuraminidase