title: Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D₂.
abstract: Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kotoku
authors.forename: Kohei
authors.initials: K
authors.lastname: Mizushima
authors.forename: Satoru
authors.initials: S
authors.lastname: Tamura
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004872:Ergocalciferols / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007536:Isomerism; D008968:Molecular Conformation; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry / Q000378:metabolism
chemical_list: D004872:Ergocalciferols; D011083:Polycyclic Compounds; C531521:cortistatin A