title: Recovery of natural killer cells and prognosis after cord blood transplantation.
abstract: The relationship between immune reconstitution and the prognosis after cord blood transplantation is unclear. We investigated the influence of natural killer (NK) cell recovery on transplant outcomes. The maximum number of CD56+CD3- cells or CD57+CD16+ cells was determined to assess NK recovery. Although the high CD56+CD3- group and high CD57+CD16+ group showed significantly better overall survival (OS) than the low group on univariate analysis, the high CD57+CD16+ group was associated with better OS on multivariate analysis. These results suggest that CD57+CD16+ cell recovery is more closely related to the outcome after CBT than CD56+CD3- cell recovery.
authors.affiliation: Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan. Electronic address: watadesu@yahoo.co.jp.
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamamoto
authors.forename: Eriko
authors.initials: E
authors.lastname: Ogusa
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Atsuo
authors.initials: A
authors.lastname: Maruta
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
authors.forename: Heiwa
authors.initials: H
authors.lastname: Kanamori
mesh_terms: D000328:Adult; D000368:Aged; D018959:CD57 Antigens / Q000378:metabolism; D036101:Cord Blood Stem Cell Transplantation; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017452:Receptors, IgG / Q000378:metabolism; D015996:Survival Rate; D055815:Young Adult
chemical_list: D018959:CD57 Antigens; D017452:Receptors, IgG
keywords: Cord blood transplantation; Natural killer cell; Prognosis