title: Cardiovascular consequences of bronchopulmonary dysplasia in prematurely born preschool children.
abstract: BACKGROUND
  A limited number of studies have reported various short-term cardiovascular changes in bronchopulmonary dysplasia (BPD) patients in the postsurfactant era. Little is known about the course of these changes in children with BPD.
  
  
  OBJECTIVE
  It was the aim of this study to investigate cardiovascular consequences of BPD at preschool ages and to find out possible risk factors related to cardiovascular sequelae.
  
  
  METHODS
  Prematurely born children with (n = 21) and without BPD (n = 20) were evaluated with conventional and myocardial tissue Doppler echocardiography at the age of 2-4 years.
  
  
  RESULTS
  BPD patients had a decreased pulmonary artery acceleration time and higher left and right ventricular myocardial performance indexes, consistent with higher pulmonary pressures and impaired biventricular systolic and diastolic functions at preschool ages. Low birth weight, disease severity and postnatal cumulative steroid dose were related to these changes.
  
  
  CONCLUSIONS
  Negative effects of BPD on global cardiac performances of both ventricles and pulmonary arterial pressure persist up to preschool ages.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Ozge Altun
authors.initials: OA
authors.lastname: Koroglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.forename: Erturk
authors.initials: E
authors.lastname: Levent
authors.forename: Mete
authors.initials: M
authors.lastname: Akisu
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kültürsay
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D002675:Child, Preschool; D015150:Echocardiography, Doppler; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology*; D007230:Infant, Low Birth Weight; D008137:Longitudinal Studies; D008297:Male; D011181:Postnatal Care; D047928:Premature Birth; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use; D018754:Ventricular Dysfunction / Q000453:epidemiology*
chemical_list: D013256:Steroids