title: Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study.
abstract: The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan, gohar.pharmacist@gmail.com.
authors.forename: Gowhar
authors.initials: G
authors.lastname: Ali
authors.forename: Fazal
authors.initials: F
authors.lastname: Subhan
authors.forename: Nazar Ul
authors.initials: NU
authors.lastname: Islam
authors.forename: Nasir
authors.initials: N
authors.lastname: Ullah
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahid
authors.forename: Sami
authors.initials: S
authors.lastname: Ullah
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ullah
authors.forename: Rehmat
authors.initials: R
authors.lastname: Shah
authors.forename: Ikhtiar
authors.initials: I
authors.lastname: Khan
authors.forename: Robert D E
authors.initials: RD
authors.lastname: Sewell
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
mesh_terms: D000818:Animals; D001241:Aspirin / Q000737:chemistry / Q000633:toxicity*; D001592:Benzyl Alcohols / Q000737:chemistry / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009584:Nitrogen / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology*
chemical_list: D001592:Benzyl Alcohols; C010631:salicyl alcohol; D009584:Nitrogen; D001241:Aspirin