title: Biphasic magnetic nanoparticles-nanovesicle hybrids for chemotherapy and self-controlled hyperthermia.
abstract: OBJECTIVE
  The aim was to develop magnetic nanovesicles for chemotherapy and self-controlled hyperthermia that prevent overheating of tissues.
  
  
  METHODS
  Magnetic nanovesicles containing paclitaxel and a dextran-coated biphasic suspension of La0.75Sr0.25MnO3 and Fe3O4 nanoparticles (magnetic nanoparticles) were developed.
  
  
  RESULTS
  Encapsulation efficiencies of magnetic nanoparticles and paclitaxel were 67 ± 5 and 83 ± 3%, respectively. Sequential release performed at 37°C for 1 h followed by 44°C for another 1 h (as expected for intratumoral injection), showed a cumulative release of 6.6% (109.6 µg), which was above the IC50 of the drug. In an alternating current magnetic field, the temperature remained controlled at 44°C and a synergistic cytotoxicity of paclitaxel and hyperthermia was observed in MCF-7 cells.
  
  
  CONCLUSIONS
  Magnetic nanovesicles containing biphasic suspensions La0.75Sr0.25MnO3 and Fe3O4 nanoparticles encapsulating paclitaxel have potential for combined self-controlled hyperthermia and chemotherapy.
authors.affiliation: Wadhwani Research Centre in Biosciences & Bioengineering, Department of Biosciences & Bioengineering, Indian Institute of Technology, Bombay, Mumbai 400076, India.
authors.forename: Manashjit
authors.initials: M
authors.lastname: Gogoi
authors.forename: Haladhar D
authors.initials: HD
authors.lastname: Sarma
authors.forename: Dhirendra
authors.initials: D
authors.lastname: Bahadur
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D002470:Cell Survival; D003911:Dextrans / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D017239:Paclitaxel / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; D017239:Paclitaxel; D052203:Ferrosoferric Oxide
keywords: biphasic suspension; cancer; chemotherapy; magnetic nanovesicle; self-controlled hyperthermia