title: Tissue resident stem cells: till death do us part.
abstract: Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin and function and thus require special attention in a type by type manner. In this paper, we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age. A comprehensive investigation of the hematopoietic, the neural, the mesenchymal, and the skeletal stem cells in age-related research highlights that distinct mechanisms are associated with the different types of tissue stem cells. The link between age-related stem cell dysfunction and human pathologies is discussed along with the challenges and the future perspectives in stem cell-based therapies in age-related diseases.
authors.affiliation: Biotalentum Ltd, Godollo, 2100, Hungary.
authors.forename: Hadas
authors.initials: H
authors.lastname: Raveh-Amit
authors.forename: Sara
authors.initials: S
authors.lastname: Berzsenyi
authors.forename: Virag
authors.initials: V
authors.lastname: Vas
authors.forename: Danna
authors.initials: D
authors.lastname: Ye
authors.forename: Andras
authors.initials: A
authors.lastname: Dinnyes
mesh_terms: D053687:Adult Stem Cells / Q000473:pathology*; D000367:Age Factors; D000375:Aging / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000473:pathology; D032448:Myoblasts, Skeletal / Q000473:pathology; D058953:Neural Stem Cells / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000473:pathology; D055153:Stem Cell Niche