title: Corneal keloid: report of natural history and outcome of surgical management in two cases.
abstract: OBJECTIVE
  To report the natural history and the outcome after the surgical management of 2 cases of corneal keloids.
  
  
  METHODS
  Two male patients, 21 and 24 years old, with a history of corneal opacity for 5 and 17 years, respectively, with no history of an ocular trauma were studied.
  
  
  RESULTS
  The first patient initially underwent a superficial keratectomy (SK), after which the corneal opacification recurred. He subsequently underwent 2 SK procedures combined with phototherapeutic keratectomy and mitomycin C, followed by a femtosecond laser-assisted deep anterior lamellar keratoplasty. The second patient underwent a bilateral SK followed by a penetrating keratoplasty in the left eye with the rapid recurrence of the lesion. The patient subsequently underwent an implantation of a Boston type 1 keratoprosthesis in the right eye, with a favorable outcome. The histopathologic features of both excised corneal specimens were consistent with the diagnosis of a corneal keloid.
  
  
  CONCLUSIONS
  Corneal keloids recur after SK and phototherapeutic keratectomy, indicating that keratoplasty procedures may be more effective than keratectomy procedures in their management. However, corneal keloids may recur even after a penetrating keratoplasty, in which case keratoprosthesis implantation represents a viable option for visual rehabilitation.
authors.affiliation: *The Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA; †Department of Ophthalmology, Weil Cornell Medical College, New York City, NY; and ‡New York Eye and Ear Infirmary, New York, NY.
authors.forename: Pejman
authors.initials: P
authors.lastname: Bakhtiari
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Agarwal
authors.forename: Ana Alzaga
authors.initials: AA
authors.lastname: Fernandez
authors.forename: Tatyana
authors.initials: T
authors.lastname: Milman
authors.forename: Ben
authors.initials: B
authors.lastname: Glasgow
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Starr
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Aldave
mesh_terms: D001187:Artificial Organs; D003315:Cornea; D003316:Corneal Diseases / Q000601:surgery*; D048988:Corneal Surgery, Laser; D006801:Humans; D007627:Keloid / Q000601:surgery*; D015948:Keratoplasty, Penetrating; D008297:Male; D019736:Prostheses and Implants; D012008:Recurrence; D016896:Treatment Outcome; D055815:Young Adult