title: A study of neuropsychiatric manifestations in patients of neurocysticercosis.
abstract: BACKGROUND
  Neurocysticercosis (NCC) is an endemic parasitic infection of Asia, Africa, Latin America, and central Europe. Neuropsychiatric manifestations of the illness include epilepsy and behavioral disturbances. There is a dearth of systematic studies on psychiatric manifestations of NCC from various Asian counties. The present study assessed the prevalence of various psychiatric disorders in a cohort of patients with NCC attending a neurological service.
  
  
  METHODS
  Detailed psychiatric assessment was carried out on 50 patients of NCC with epilepsy and 50 patients of epilepsy without any evidence of NCC. Comprehensive Psychopathological Rating Scale was used to elicit the symptoms. Cognitive functions were assessed using Mini Mental Status Examination. Psychiatric diagnoses were made as per International Classification of Diseases, 10(th) edition (ICD-10).
  
  
  RESULTS
  Sixty eight percent of the patients with NCC suffered from a psychiatric disorder, as compared to 44% of those without NCC (P=0.02). Major depression and mixed anxiety depression were the two most common diagnoses. None of the patients was to found to suffer from a psychotic disorder. The most frequent site of brain lesion of NCC was the parietal lobe, followed by frontal lobes and disseminated lesions. Left sided lesions were associated with greater psychiatric morbidity. Focal seizures with or without secondary generalizations were present more frequently in patients with NCC whereas primary generalized seizures were more common in patients with idiopathic epilepsy (P=0.05).
  
  
  CONCLUSIONS
  Psychiatric manifestations are more common in patients of epilepsy with NCC than those without NCC. The treating clinician need to be vigilant about the phenomenon.
authors.affiliation: Department of Psychiatry, Institute of Human Behaviour and Allied Sciences, Delhi, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Srivastava
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Chadda
authors.forename: Kiran
authors.initials: K
authors.lastname: Bala
authors.forename: Pradipta
authors.initials: P
authors.lastname: Majumdar
keywords: Idiopathic epilepsy; neurocysticercosis; psychiatric comorbidity