title: [Study of antioxidant activity of phenolic compounds from some species of Georgian flora].
abstract: The antioxidant activity of extracts obtained from different parts of Georgian flora species Hamamelis virginiana L., Astragalus caucasicus Pall., Astragalus microcephalus Willd., Vitis vinifera L., Rhododendron ponticum L., Rhododendron Ungernii Trautv., Ginkgo biloba L., Salvia officinalis L., Querqus iberica Stev., Maclura aurantiaca Nutt., Cotinus coggygria Ledeb., Fraxinus ornus L., Urtica dioica L., Rhododendron caucasicum Pall., Pueraria hirsuta Matsum., Geranium pusillum L., Astragalus Tanae Sosn., Pinus silvestris L. has been studied. Comparison with ethylentetraacetate and α-tocopherole revealed high efficacy of all extracts studied. 45 individual phenolic compounds were isolated and described by chemical examination of biologically active objects. Common sage (Salvia officinalis) extract turned out as the most active (200 %). The chemical study revealed the dominant content of condensed tannins and low molecular phenolic compounds, which may be attributed to the high antioxidant activity. Biologically active antiatherosclerotic food additive "Salbin" was developed on the basis of Common sage - Salvia officinalis L. phenolic compounds.
authors.affiliation: Tbilisi State Medical University; I.Kutateladze Institute of Pharmacochemistry, Tbilisi Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Alaniia
authors.forename: K
authors.initials: K
authors.lastname: Shalashvili
authors.forename: T
authors.initials: T
authors.lastname: Sagareishvili
authors.forename: N
authors.initials: N
authors.lastname: Kavtaradze
authors.forename: M
authors.initials: M
authors.lastname: Sutiashvili
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005846:Georgia (Republic); D006801:Humans; D010084:Oxidation-Reduction; D010636:Phenols / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry*; D027543:Salvia officinalis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts