title: Stereotactic radiosurgery of intracranial arteriovenous malformations.
abstract: Stereotactic radiosurgery for intracranial arteriovenous malformations (AVMs) has been performed since the 1970s. When an AVM is treated with radiosurgery, radiation injury to the vascular endothelium induces the proliferation of smooth muscle cells and the elaboration of extracellular collagen, which leads to progressive stenosis and obliteration of the AVM nidus. Obliteration after AVM radiosurgery ranges from 60% to 80%, and relates to the size of the AVM and the prescribed radiation dose. The major drawback of radiosurgical AVM treatment is the risk of bleeding during the latent period (typically 2 years) between treatment and AVM thrombosis.
authors.affiliation: Department of Neurological Surgery, University of Florida, PO Box 100265, MBI, Gainesville, FL 32610, USA. Electronic address: friedman@neurosurgery.ufl.edu.
authors.forename: William A
authors.initials: WA
authors.lastname: Friedman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001164:Arteriovenous Fistula / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D055815:Young Adult
keywords: Arteriovenous malformation; Gamma knife; Linear accelerator; Radiosurgery