title: Study of thrombophilia in recurrent pregnancy loss.
abstract: OBJECTIVE
  Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss.
  
  
  METHODS
  53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study.
  
  
  RESULTS
  Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level.
  
  
  CONCLUSIONS
  This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss.
authors.affiliation: NRS Medical College, Kolkata, India ; C/O-Sri R C Hansda, 2/2 Krittibas Road (South), B-Zone, Durgapur, Burdwan, 713205 WB Kolkata, India.
authors.forename: Jayasree
authors.initials: J
authors.lastname: Hansda
authors.forename: Joydeb
authors.initials: J
authors.lastname: Roychowdhury