title: A multiscale model of the electrohysterogram the BioModUE_PTL project.
abstract: The electrohysterogram (EHG) is a promising means of monitoring pregnancy and of detecting a risk of preterm labor. To improve our understanding of the EHG as well as its relationship with the physiologic phenomena involved in uterine contractility, we plan to model these phenomena in terms of generation and propagation of uterine electrical activity. This activity can be realistically modeled by representing the principal ionic dynamics at the cell level, the propagation of electrical activity at the tissue level and then the way it is reflected on the skin surface through the intervening tissue. We present in this paper the different steps leading to the development and validation of a biophysics based multiscale model of the EHG, going from the cell to the electrical signal measured on the abdomen.
authors.forename: Catherine
authors.initials: C
authors.lastname: Marque
authors.forename: Jérémy
authors.initials: J
authors.lastname: Laforêt
authors.forename: Chiara
authors.initials: C
authors.lastname: Rabotti
authors.forename: Asgeir
authors.initials: A
authors.lastname: Alexandersson
authors.forename: Guy
authors.initials: G
authors.lastname: Germain
authors.forename: Jean
authors.initials: J
authors.lastname: Gondry
authors.forename: Brynjar
authors.initials: B
authors.lastname: Karlsson
authors.forename: Brane
authors.initials: B
authors.lastname: Leskosek
authors.forename: Massimo
authors.initials: M
authors.lastname: Mischi
authors.forename: Charles
authors.initials: C
authors.lastname: Muszinski
authors.forename: Guid
authors.initials: G
authors.lastname: Oei
authors.forename: Jan
authors.initials: J
authors.lastname: Peuscher
authors.forename: Drago
authors.initials: D
authors.lastname: Rudel
mesh_terms: D003198:Computer Simulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008954:Models, Biological; D015999:Multivariate Analysis; D007752:Obstetric Labor, Premature / Q000175:diagnosis; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014590:Uterine Contraction; D018590:Uterine Monitoring / Q000379:methods; D014599:Uterus / Q000502:physiology