title: [Association of the incidence of type 1 diabetes mellitus with environmental factors in Chile during the period 2000-2007].
abstract: BACKGROUND
  Pollution and viral infections could be associated with the incidence of type 1 diabetes mellitus.
  
  
  OBJECTIVE
  To look for associations between the temporal patterns of Type 1 Diabetes Mellitus (T1D) in infants younger than the age of 15 years, and environmental factors, such as air pollution and viruses.
  
  
  METHODS
  Data registries from hospitals, emergency services, and the Infantile Diabetes Foundation were reviewed, corresponding to children aged less than 15 years, who received their first insulin injection between 2000 and 2007. The incidence of type 1 diabetes was computed for each epidemiological week. Environmental ozone and particulate matter rates for each week were obtained from Environmental services. Rates of influenza and respiratory syncytial virus infections were obtained from the epidemiological department of the Ministry of Health. An ecological Bayesian Poisson regression model was fitted, introducing the covariates, lagged covariates and errors, to estimate the incidence by epidemiological week.
  
  
  RESULTS
  Three factors were significant by the proposed model: particulate matter PPM 2.5 (relative risk (RR): 1.003) lagged by two weeks, influenza (RR: 0.1808) and RSV (RR: 1.021). Trends and seasonality were clearly controlled by these covariates, considering the epidemiological week as a counting period.
  
  
  CONCLUSIONS
  These results show that environmental factors could be related to peaks of type 1 diabetes incidence.
authors.affiliation: Departamento de Matemática y Ciencia de la Computación, Universidad de Santiago de Chile, Chile.
authors.forename: Nelly
authors.initials: N
authors.lastname: González R
authors.forename: Francisco
authors.initials: F
authors.lastname: Torres-Avilés
authors.forename: Elena
authors.initials: E
authors.lastname: Carrasco P
authors.forename: Francisca
authors.initials: F
authors.lastname: Salas P
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez B
mesh_terms: D000293:Adolescent; D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects*; D002677:Chile / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology*; D010126:Ozone / Q000009:adverse effects*; D052638:Particulate Matter / Q000009:adverse effects; D016012:Poisson Distribution; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000453:epidemiology*
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D010126:Ozone