title: Glucose transporter 3 and 1 may facilitate high uptake of 18F-FDG in gastric schwannoma.
abstract: Recently, some gastric schwannomas have been reported to have high uptake of FDG. However, Glut-1 was reported to be negative in gastric schwannomas tested. A 64-year-old female patient received a laparoscopic partial gastrectomy for a FDG PET-positive submucosal tumor (SUVmax 6.61). The resected tumor was diagnosed as a benign gastric schwannoma. Glut family immunohistochemical examination revealed diffuse positive expression of Glut-3 and partial positive expression of Glut-1. On the other hand, Glut-2 and Glut-4 expression in the tumor were negative. This case suggested that Glut-3 and Glut-1 expression were facilitators of high FDG uptake in the benign gastric schwannoma.
authors.affiliation: From the *Department of Surgery and Science, and †Department of Pathology, Graduate School of Medicine & Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shimada
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Sawada
authors.forename: Shozo
authors.initials: S
authors.lastname: Hojo
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Okumura
authors.forename: Takuya
authors.initials: T
authors.lastname: Nagata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nomoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsukada
mesh_terms: D004724:Endoscopy; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D051273:Glucose Transporter Type 2 / Q000378:metabolism; D051274:Glucose Transporter Type 3 / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009442:Neurilemmoma / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D051272:Glucose Transporter Type 1; D051273:Glucose Transporter Type 2; D051274:Glucose Transporter Type 3; D051275:Glucose Transporter Type 4; C495677:SLC2A1 protein, human; C495680:SLC2A2 protein, human; C495687:SLC2A3 protein, human; C495692:SLC2A4 protein, human; D019788:Fluorodeoxyglucose F18