title: Assembly of catalase-based bioconjugates for enhanced anticancer efficiency of photodynamic therapy in vitro.
abstract: An oxygen generation core-shell structure uploading rose bengal has been fabricated by covalent assembly of catalase and alginate dialdehyde via Schiff's base. The composite can catalyze the decomposition of intracellular H2O2 to increase the concentration of O2, which effectively enhances the anticancer efficiency of photodynamic therapy in vitro.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China. jbli@iccas.ac.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fei
authors.forename: Cuiling
authors.initials: C
authors.lastname: Du
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Hongchao
authors.initials: H
authors.lastname: Ma
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000464:Alginates / Q000737:chemistry; D002119:Calcium Carbonate; D002214:Capsules; D002374:Catalase / Q000627:therapeutic use*; D006801:Humans; D006861:Hydrogen Peroxide; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy / Q000379:methods; D012395:Rose Bengal / Q000627:therapeutic use*
chemical_list: D000464:Alginates; D002214:Capsules; D012395:Rose Bengal; D006861:Hydrogen Peroxide; D002374:Catalase; D002119:Calcium Carbonate