title: Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.
abstract: Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.
authors.affiliation: VirPath, EA4610 Virologie et Pathologie Humaine, Faculté de médecine RTH Laennec, Université Claude Bernard Lyon 1, Université de Lyon, 69008, Lyon, France.
authors.forename: Fatma
authors.initials: F
authors.lastname: Berri
authors.forename: Vuong Ba
authors.initials: VB
authors.lastname: Lê
authors.forename: Martine
authors.initials: M
authors.lastname: Jandrot-Perrus
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.forename: Béatrice
authors.initials: B
authors.lastname: Riteau
mesh_terms: D059951:HLA-G Antigens / Q000378:metabolism; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007157:Immunologic Surveillance / Q000276:immunology*; D007249:Inflammation / Q000209:etiology / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D018448:Models, Immunological; D044463:Receptor, PAR-1 / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D059951:HLA-G Antigens; C085820:INS1 protein, influenza virus; C442816:PB1-F2 protein, Influenza A virus; D044463:Receptor, PAR-1; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins