title: TGF-β: guardian of T cell function.
abstract: A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-β production and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-β regulation of T cells.
authors.affiliation: Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
authors.forename: Soyoung A
authors.initials: SA
authors.lastname: Oh
authors.forename: Ming O
authors.initials: MO
authors.lastname: Li
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D019070:Cell Lineage; D004789:Enzyme Activation; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D017634:Self Tolerance; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000276:immunology* / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta