title: Fish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicity.
abstract: OBJECTIVE
  The protective effects of fish oil (FO) on cisplatin (CP)-induced central and peripheral neurotoxicity were investigated in rats.
  
  
  METHODS
  Rats (n = 28) were divided equally into four groups, the first group was kept as a control. In the second and third groups, CP and FO were given at doses of 7 mg/kg and 1 softgel/rat/day, respectively. In the fourth group, CP and FO were given together at the same doses.
  
  
  RESULTS
  Although CP caused significant oxidative damage, via induction of lipid peroxidation and reduction in the antioxidant defense system potency, FO treatment largely reversed these effects. CP also resulted in histopathological damage, such as apoptosis, and electromyographical changes in the sciatic nerve. FO treatment partially prevented the histopathological and electromyographical effects of CP.
  
  
  CONCLUSIONS
  CP has severe central and peripheral neurotoxic effects in rats and these effects were largely prevented by FO treatment. Thus, it appears that co-administration of FO with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.
authors.forename: Suat
authors.initials: S
authors.lastname: Kamisli
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.forename: Asli
authors.initials: A
authors.lastname: Cetin
authors.forename: Kursat
authors.initials: K
authors.lastname: Kaya
authors.forename: Ozden
authors.initials: O
authors.lastname: Kamisli
authors.forename: Hamit
authors.initials: H
authors.lastname: Celik
mesh_terms: D000818:Animals; D021322:Antifreeze Proteins, Type I / Q000008:administration & dosage*; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D002945:Cisplatin / Q000633:toxicity*; D004576:Electromyography; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D021322:Antifreeze Proteins, Type I; D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002945:Cisplatin
keywords: Cisplatin; Electromyography; Fish oil; Neuropathy; Oxidative damage