title: Nutritional signals and reproduction.
abstract: There is extensive evidence that nutrition influences reproductive function in various mammalian species (agricultural animals, rodents and human). However, the mechanisms underlying the relationship between nutrition, energy metabolism and reproductive function are poorly understood. This review considers nutrient sensors as a molecular link between food molecules and consequences for female and male fertility. It focuses on the roles and the molecular mechanisms of some of the relevant hormones, such as insulin and adipokines, and of energy substrates (glucose, fatty acids and amino acids), in the gonadotropic axis (central nervous system and gonads). A greater understanding of the interactions between nutrition and fertility is required for both better management of the physiological processes and the development of new molecules to prevent or cure metabolic diseases and their consequences for fertility.
authors.affiliation: UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France. Electronic address: jdupont@tours.inra.fr.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Dupont
authors.affiliation: UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Reverchon
authors.affiliation: UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bertoldo
authors.affiliation: UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Froment
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D012098:Reproduction / Q000502:physiology*
chemical_list: D054392:Adipokines; D005227:Fatty Acids; D007328:Insulin; D005947:Glucose
keywords: Energy sensors; Fertility; Metabolic factors; Signaling pathways