title: Spectroscopic and molecular modeling studies of the interaction between morin and polyamidoamine dendrimer.
abstract: Interactions between the polyamidoamine (PAMAM) dendrimer and drug molecules are of interest for their potential biomedical applications. The goal of this work is to examine the interaction of PAMAM-C12 25% dendrimer with morin. The ultraviolet-visible, fluorescence spectroscopic methods as well as molecular modeling were used to analyze drug-binding mode, binding constants and binding sites, etc. The experimental data showed that the binding constant of morin-PAMAM-C12 25% is about 10(5) L/mol. The interaction of morin with PAMAM-C12 25% is mainly driven by the hydrophobic, electrostatic, hydrogen bonds and van der Waals forces. There are mainly three classes of binding site of morin at the interface of PAMAM-C12 25%. These results provided some useful information for self-assembling and disassembling the PAMAM dendrimer as well as efficient drug delivery and therapeutic applications.
authors.affiliation: Institute of Applied Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng City, Jiangsu Province, 224002, People's Republic of China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D008958:Models, Molecular; D011073:Polyamines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D047309:Flavones
chemical_list: D050091:Dendrimers; D005419:Flavonoids; D011073:Polyamines; C531249:Poly(amidoamine); C008548:morin; D047309:Flavones
keywords: PAMAM-C12 25%; binding mode; binding site; morin