title: Using oxidized low-density lipoprotein autoantibodies to predict restenosis after balloon angioplasty in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Oxidized low-density lipoproteins (oxLDL) and oxidized low-density lipoprotein autoantibodies (OLAB) have been detected in human plasma and atherosclerotic lesions. OLAB appear to play a role in the clearance of oxLDL from circulation. Higher levels of OLAB appear to be associated with a reduced risk of a wide range of cardiovascular diseases. We investigated the prognostic value of plasma oxLDL and OLAB in patients undergoing primary coronary balloon angioplasty for acute ST-elevation myocardial infarction (STEMI).
  
  
  METHODS
  Plasma oxLDL and OLAB concentrations were measured in 56 patients with acute STEMI before primary angioplasty, and then 3 days, 7 days and 1 month after the acute event. Follow-up angiography was repeated 6 months later to detect the presence of restensosis (defined as >50% luminal diameter stenosis). The thrombolysis in myocardial infarction (TIMI) risk score was calculated to determine the relationship between OLAB/oxLDL ratio and TIMI risk scores.
  
  
  RESULTS
  Of the 56 patients, 18 (31%) had angiographic evidence of restenosis. Plasma OLAB concentrations were significantly lower in the restenosis group before angioplasty (181±114 vs. 335±257 U/L, p = 0.003), and at day 3 (155±92 vs. 277±185 U/L, p<0.001) and day 7 (177±110 vs. 352±279 U/L, p<0.001) after the acute event. There was no difference in oxLDL concentration between the two groups. The ratio of OLAB/oxLDL positively correlated with TIMI risk scores before angioplasty (p for trend analysis, p = 0.004), at day 3 (p = 0.008) and day 7 (p<0.001) after STEMI.
  
  
  CONCLUSIONS
  A relative deficit of OLAB, and hence likely impaired clearance of oxLDL, is associated with the risk of arterial restenosis after primary angioplasty for acute STEMI.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan ; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Ching-Hui
authors.initials: CH
authors.lastname: Huang
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Chang
authors.forename: Ching-Shan
authors.initials: CS
authors.lastname: Huang
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Kuo
authors.forename: Ching-Pei
authors.initials: CP
authors.lastname: Chen
authors.forename: Chien-Hsun
authors.initials: CH
authors.lastname: Hsia
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Chang
authors.forename: Hung-Te
authors.initials: HT
authors.lastname: Chen
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Feng
authors.forename: Lee-Shin
authors.initials: LS
authors.lastname: Lin
authors.forename: Po-Ta
authors.initials: PT
authors.lastname: Yang
authors.forename: Chen-Dao
authors.initials: CD
authors.lastname: Tsai
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Lin
authors.forename: Chin-San
authors.initials: CS
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D015906:Angioplasty, Balloon, Coronary; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D023903:Coronary Restenosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D011379:Prognosis; D011859:Radiography; D012306:Risk
chemical_list: D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein