title: Differential impairment of social cognition factors in bipolar disorder with and without psychotic features and schizophrenia.
abstract: While it is well-established that patients with schizophrenia and bipolar disorder exhibit deficits in social cognition, few studies have separately examined bipolar disorder with and without psychotic features. The current study addressed this gap by comparing patients with bipolar disorder with (BD+) and without (BD-) psychotic features, patients with schizophrenia (SZ), and healthy controls (NC) across social cognitive measures. Principal factor analysis on five social cognition tasks extracted a two-factor structure comprised of social/emotional processing and theory of mind. Factor scores were compared among the four groups. Results identified differential patterns of impairment between the BD+ and BD- group on the social/emotional processing factor while all clinical groups performed poorer than controls on the theory of mind factor. This provides evidence that a history of psychosis should be taken into account while evaluating social cognition in patients with bipolar disorder and also raises hypotheses about the relationship between social cognition and psychosis.
authors.affiliation: University of Nevada, Las Vegas, Las Vegas, NV, USA. Electronic address: Nthaler@mednet.ucla.edu.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Thaler
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Allen
authors.forename: Griffin P
authors.initials: GP
authors.lastname: Sutton
authors.forename: Mary
authors.initials: M
authors.lastname: Vertinski
authors.forename: Erik N
authors.initials: EN
authors.lastname: Ringdahl
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications* / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications*; D011932:Reading; D021641:Recognition, Psychology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D055815:Young Adult
keywords: Bipolar disorder; Emotion processing; Factor analysis; Psychosis; Social cognition; Theory of mind