title: Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome.
abstract: BACKGROUND
  It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon.
  
  
  RESULTS
  To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4(+) T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4(+) T cells.
authors.affiliation: School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, Buck Institute for Research on Aging, Novato, CA 94945, USA and PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia.
authors.forename: Daudi
authors.initials: D
authors.lastname: Jjingo
authors.forename: Jianrong
authors.initials: J
authors.lastname: Wang
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Conley
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Lunyak
authors.forename: I King
authors.initials: IK
authors.lastname: Jordan
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics*; D047369:Chromatin Immunoprecipitation; D019295:Computational Biology; D005786:Gene Expression Regulation; D015894:Genome, Human; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*
chemical_list: D002843:Chromatin