title: Ochratoxin A levels in blood serum of Czech women in the first trimester of pregnancy and its correspondence with dietary intake of the mycotoxin contaminant.
abstract: The mycotoxin ochratoxin A (OTA) can elicit a wide range of toxic properties including embryotoxicity and teratogenicity. OTA crosses the placenta at early gestation rather than in late gestation, maternal OTA exposure may represent a risk for the developing fetus. The study focuses on the assessment of OTA intake of pregnant women (aged 19-40 years) in the first trimester of pregnancy by means OTA levels in 100 blood serum samples by high-performance liquid chromotography with fluorescence detection (HPLC-FD) method and comparison with dietary OTA exposure in pregnant women. Of all, 96% tested serum samples were positive with values ranging from 0.1 to 0.35 µg/l with a mean value of 0.15 µg/l.
authors.affiliation: Department of Biology, Faculty of Science, University of Hradec Kralove , Czech Republic .
authors.forename: Frantisek
authors.initials: F
authors.lastname: Malir
authors.forename: Vladimir
authors.initials: V
authors.lastname: Ostry
authors.forename: Marcela
authors.initials: M
authors.lastname: Dofkova
authors.forename: Tomas
authors.initials: T
authors.lastname: Roubal
authors.forename: Vladimir
authors.initials: V
authors.lastname: Dvorak
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Dohnal
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003604:Czechoslovakia; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008875:Middle Aged; D009183:Mycotoxins / Q000008:administration & dosage*; D009793:Ochratoxins / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013050:Spectrometry, Fluorescence; D055815:Young Adult
chemical_list: D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A