title: Three-component cascade annulation of β-ketothioamides promoted by CF3CH2OH: a regioselective synthesis of tetrasubstituted thiophenes.
abstract: A rapid and highly efficient method for the regioselective synthesis of thiophene derivatives has been developed by annulation of β-ketothioamides with arylglyoxals and 5,5-dimethyl-1,3-cyclohexanedione in CF3CH2OH within 15 min. The present synthesis has several desirable features, such as high regioselectivity, a concise one-pot protocol, short reaction time, and easy purification. This methodology provides an alternative approach for easy access to tetrasubstituted thiophenes via a one-pot cascade reaction without other additives.
authors.affiliation: State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, P. R. China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wen
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Ming-Chao
authors.initials: MC
authors.lastname: Lan
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D005960:Glucosides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005960:Glucosides; D013854:Thioamides; D013876:Thiophenes