title: Multidisciplinary one-stage risk-reducing gynaecological and breast surgery with immediate reconstruction in BRCA-gene carrier women.
abstract: Familial breast cancer accounts for 5-10% of all breast cancers. Due to BRCA1/2 tumour suppressor gene mutation, hereditary breast and ovarian syndrome is the most common form. Risk-reducing gynaecological and breast surgery is offered to such patients in ever-increasing numbers. Hence, the development of a multi-specialty combined treatment approach is called for. Twenty-two BRCA gene-mutation carrier women underwent one-stage gynaecological and breast risk-reducing surgery and immediate reconstruction between January 2005 and December 2011 at the Belfast City Hospital. Their mean age was 41.2 years (median 41 years). Nearly half of the patients were BRCA2 and a quarter were BRCA1 carriers. The rest were positive for both genes. Hormone-replacement therapy was initiated in 14 women. Average theatre time and stay in the hospital were three hours and two and a half days, respectively. Two patients developed complications unrelated to combining the procedures. Both were treated conservatively and recovered. The one-stage approach logically proves economical by limiting the time the patients are in the hospital and away from work. We describe our multidisciplinary team service that is offering safe and economical one-stage risk-reducing surgery and reconstruction to young BRCA gene-mutation carrier women in Northern Ireland.
authors.affiliation: Department of Plastic Surgery, Belfast City Hospital, Belfast, Northern Ireland BT16 1QN, United Kingdom. Electronic address: drfaheemk2002@yahoo.com.
authors.forename: M F
authors.initials: MF
authors.lastname: Khadim
authors.forename: P
authors.initials: P
authors.lastname: Eastwood
authors.forename: J
authors.initials: J
authors.lastname: Price
authors.forename: P
authors.initials: P
authors.lastname: Morrison
authors.forename: K
authors.initials: K
authors.lastname: Khan
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D007902:Length of Stay; D016462:Mammaplasty; D008408:Mastectomy; D008875:Middle Aged; D009154:Mutation; D061646:Operative Time; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D010052:Ovariectomy; D010348:Patient Care Team; D018570:Risk Assessment; D058994:Salpingectomy
keywords: BRCA; Breast cancer; Ovarian cancer; Risk-reducing surgery