title: Cytotoxic Compounds from Brucea mollis.
abstract: Ten compounds, including soulameanone (1), isobruceine B (2), 9-methoxy-canthin-6-one (3), bruceolline F (4), niloticine (5), octatriacontan-1-ol (6), bombiprenone (7), α-tocopherol (8), inosine (9), and apigenin 7-O-β-D-glucopyranoside (10), were isolated from the leaves, stems, and roots of Brucea mollis Wall. ex Kurz. Their structures were determined using one-and two-dimensional NMR spectroscopy and mass spectrometry. All compounds were evaluated for their cytotoxic activity against KB (human carcinoma of the mouth), LU-1 (human lung adenocarcinoma), LNCaP (human prostate adeno-carcinoma), and HL-60 (human promyelocytic leukemia) cancer cell lines. Compound 2 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values of 0.39, 0.40, 0.34, and 0.23 μg/mL, respectively. In addition, compounds 3 and 5 showed significant cytotoxic activity against KB, LU-1, LNCaP, and HL-60 cancer cells with IC50 values around 1-4 μg/mL. Compounds 9-methoxycanthin-6-one (3) and niloticine (5) have been discovered for the first time from the Brucea genus.
authors.affiliation: Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet street, Cau Giay, Hanoi, Vietnam.
authors.forename: Mai Hung Thanh
authors.initials: MH
authors.lastname: Tung
authors.forename: Ho Viet
authors.initials: HV
authors.lastname: Duc
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Huong
authors.forename: Nguyen Thanh
authors.initials: NT
authors.lastname: Duong
authors.forename: Do Thi
authors.initials: do T
authors.lastname: Phuong
authors.forename: Do Thi
authors.initials: do T
authors.lastname: Thao
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Tran The
authors.initials: TT
authors.lastname: Bach
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
keywords: Alkaloids; Brucea mollis; Cytotoxicity; Quassinoids; Triterpenoids