title: Age, plasticity, and homeostasis in childhood brain disorders.
abstract: It has been widely accepted that the younger the age and/or immaturity of the organism, the greater the brain plasticity, the young age plasticity privilege. This paper examines the relation of a young age to plasticity, reviewing human pediatric brain disorders, as well as selected animal models, human developmental and adult brain disorder studies. As well, we review developmental and childhood acquired disorders that involve a failure of regulatory homeostasis. Our core arguments are as follows:
authors.affiliation: Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1X8, Canada. Electronic address: maureen.dennis@sickkids.ca.
authors.forename: Maureen
authors.initials: M
authors.lastname: Dennis
authors.forename: Brenda J
authors.initials: BJ
authors.lastname: Spiegler
authors.forename: Jenifer J
authors.initials: JJ
authors.lastname: Juranek
authors.forename: Erin D
authors.initials: ED
authors.lastname: Bigler
authors.forename: O Carter
authors.initials: OC
authors.lastname: Snead
authors.forename: Jack M
authors.initials: JM
authors.lastname: Fletcher
mesh_terms: D000375:Aging; D001927:Brain Diseases / Q000503:physiopathology*; D002648:Child; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*
keywords: Age at brain injury; Childhood-acquired brain damage; Homeostasis; Neurodevelopmental disorders; Plasticity; Time since brain injury