title: High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.
abstract: The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
authors.affiliation: INSERM, U1012, Bicêtre, France ; AP-HP, Department of Internal Medicine and Infectious Diseases, Bicêtre Hospital, Bicêtre, France ; University Paris-Sud, Bicêtre, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
authors.forename: Justin
authors.initials: J
authors.lastname: Pollara
authors.forename: Faroudy
authors.initials: F
authors.lastname: Boufassa
authors.forename: Christiane
authors.initials: C
authors.lastname: Moog
authors.forename: Alain
authors.initials: A
authors.lastname: Venet
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Asier
authors.initials: A
authors.lastname: Saez-Cirion
authors.forename: Guido
authors.initials: G
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000276:immunology; D014766:Viremia / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D015235:HLA-B Antigens; C103707:HLA-B57 antigen; D012367:RNA, Viral