title: Characterization of pressure reduction in coil-filled aneurysm under flow of human blood with and without anti-coagulant.
abstract: Filling aneurysms with embolization coils is a widely used part of the treatment to stop intracranial aneurysm from rupturing. However, the effect of coiling on aneurysmal pressure has not been established. In this study, the effect of intra-aneurysmal coiling on pressure reduction was characterized. Coil deployment in the aneurysm will disturb flow and may induce aneurysmal coagulation. These effects were experimentally examined in this study using silicone rubber saccular aneurysm models. Changes in aneurysmal blood pressure under pulsatile flow were characterized. With coils in the aneurysm, results showed that flow reduction of anti-coagulated blood in the aneurysm did not reduce aneurysmal pressure. Significant pressure reduction was observed only when the blood's coagulation ability is restored to normal. These results suggest that blood coagulation is pivotal to pressure reduction and concomitant with rupture risk reduction in treatments of aneurysm with coils.
authors.forename: Alexander K N
authors.initials: AK
authors.lastname: Lam
authors.forename: Match W L
authors.initials: MW
authors.lastname: Ko
authors.forename: Leo K K
authors.initials: LK
authors.lastname: Leung
authors.forename: John C K
authors.initials: JC
authors.lastname: Kwok
authors.forename: Mathew M F
authors.initials: MM
authors.lastname: Yuen
authors.forename: David C C
authors.initials: DC
authors.lastname: Lam
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004621:Embolization, Therapeutic; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy*; D008954:Models, Biological; D011673:Pulsatile Flow / Q000502:physiology*
chemical_list: D000925:Anticoagulants