title: Isotretinoin updates.
abstract: Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles commonly affecting adolescents and young adults. This disease has a profound psychological impact on affected individuals and treatment has been shown to significantly improve both self-esteem and quality of life. Isotretinoin is an effective medication used primarily in severe cystic acne patients. Over the past 30 years, this medication has revolutionized the treatment of acne. However, despite its popularity there are numerous side effects associated with its use. Most of its side effects are predictable and dose dependent, which has led to the development of variable dose regimens. Unfortunately, rare but significant side effects (e.g., depression, inflammatory bowel disease) do occur and necessitate careful monitoring to improve clinical outcomes and minimize potential adverse events.
authors.affiliation: Department of Dermatology, The Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Shelbi C Jim
authors.initials: SC
authors.lastname: On
authors.forename: Joshua
authors.initials: J
authors.lastname: Zeichner
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D000293:Adolescent; D003863:Depression / Q000139:chemically induced / Q000453:epidemiology; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000453:epidemiology; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011788:Quality of Life; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: acne; isotretinoin; updates