title: Activating group recycling in action: a rhodium-catalyzed carbothiolation route to substituted isoquinolines.
abstract: A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a 'recycled methyl sulfide' activating group, are convenient precursors to highly substituted isoquinolines.
authors.affiliation: Department of Chemistry, University of Oxford , Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.
authors.forename: Milan
authors.initials: M
authors.lastname: Arambasic
authors.forename: Joel F
authors.initials: JF
authors.lastname: Hooper
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry
chemical_list: D000480:Alkynes; D007546:Isoquinolines; D007659:Ketones; D013438:Sulfhydryl Compounds; D013440:Sulfides; D012238:Rhodium