title: Association of blood pressure with development of metabolic syndrome components: a five-year Retrospective Cohort study in Beijing.
abstract: BACKGROUND
  Raised blood pressure (BP) is associated with the incidence of metabolic syndrome (MetS). It is unknown if subjects with different BP levels may develop certain components of MetS over time. We investigated the incidence of MetS relative to different levels of BP over a 5-year period in a Chinese population in Tongren Hospital, Beijing.
  
  
  METHODS
  During the period of 2006-2011, we recruited 2,781 participants with no MetS, or self-reported type 2 diabetes, dyslipidemia, hypertension, or cardiovascular disease at baseline. Association rule was used to identify the transitions of MetS components over time.
  
  
  RESULTS
  The incidence of MetS at follow-up was 9.74% for men and 3.21% for women in the group with optimal BP; 10.29% and 7.22%, respectively, in the group with normal BP; 10.49% and 10.84%, respectively, in the group with high-normal BP; and 14.48% and 23.21%, respectively in the group with high BP. The most common transition was from healthy to healthy in the groups with optimal or normal BP (17.9-49.3%), whereas in the high-normal BP group, 16.9-22.1% of subjects with raised BP returned to healthy status or stayed unchanged, while 13.8-21.4% of people with high BP tended to develop raised fasting glucose levels.
  
  
  CONCLUSIONS
  The incidence of MetS increased in parallel with the increase in BP. People with optimal and normal BP levels were less susceptible to developing MetS over time, whereas abnormal BP seemed to be a pre-existing phase of MetS. High-normal BP was a crucial status for MetS prevention.
authors.affiliation: School of Public Health, Capital Medical University, No, 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing 100069, China. guoxiuh@ccmu.edu.cn.
authors.forename: Da
authors.initials: D
authors.lastname: Huo
authors.forename: Lixin
authors.initials: L
authors.lastname: Tao
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Wang
authors.forename: Dongning
authors.initials: D
authors.lastname: Chen
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhu
authors.forename: Xinghua
authors.initials: X
authors.lastname: Yang
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose