title: Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives.
abstract: Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.
authors.affiliation: Dpto. de Química Orgánica e Inorgánica, Universidad de Oviedo. c/Julián Clavería 8, 33006, Oviedo, Spain. lavanderaivan@uniovi.es vgs@uniovi.es.
authors.forename: Aníbal
authors.initials: A
authors.lastname: Cuetos
authors.forename: Iván
authors.initials: I
authors.lastname: Lavandera
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D007700:Kinetics; D013237:Stereoisomerism; D000637:Transaminases / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D004952:Esters; D000637:Transaminases