title: Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis.
abstract: BACKGROUND
  Several studies analyzed the associations of Vitamin D receptor (VDR) polymorphisms with urolithiasis risk in different ethnic groups. However, the results were inconclusive. To evaluate a more precise estimation of the relationship, a meta-analysis was performed.
  
  
  METHODS
  Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two investigators. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.
  
  
  RESULTS
  Twenty-three case-control studies were included in this meta-analysis. Significant associations between ApaI, BsmI, FokI, and TaqI polymorphisms and urolithiasis risk were observed. However, sensitivity analyses for BsmI and FokI polymorphisms indicated that the results were not reliable and credible. In addition, there was a significant association of the ApaI-TaqI haplotype with urolithiasis risk.
  
  
  CONCLUSIONS
  This meta-analysis suggested that ApaI and TaqI polymorphisms in VDR gene were associated with urolithiasis risk.
authors.affiliation: Department of Nephrology, the First People's Hospital of Jingzhou City, the First Hospital of Yangtze University, Jingzhou, Hubei Province 434000, China. drjianghong@163.com.
authors.forename: Pan
authors.initials: P
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D030541:Databases, Genetic; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D004198:Disease Susceptibility; D006239:Haplotypes; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D052878:Urolithiasis / Q000235:genetics* / Q000473:pathology
chemical_list: D018167:Receptors, Calcitriol; D015252:Deoxyribonucleases, Type II Site-Specific