title: Findings of 123I-iomazenil SPECT during and after stroke-like episodes in a patient with MELAS.
abstract: Reduced cortical benzodiazepine receptor binding potential in late images of I-iomazenil SPECT indicates neuronal damage in the cortex. We present the case of a 31-year-old woman with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had focal seizures in the right hand. FLAIR imaging in the ictal state revealed a high-intensity lesion in the left post-central gyrus, while I-iomazenil SPECT showed decreased tracer uptake in this lesion. The lesion completely disappeared on FLAIR imaging performed 1 month after the focal seizures; in contrast, I-iomazenil SPECT still revealed a significant decrease in tracer uptake in this lesion.
authors.affiliation: From the *Department of Neurology, Toyama University Hospital, Toyama, and †The Department of Radiology, Toyama University, Toyama, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Shutaro
authors.initials: S
authors.lastname: Takashima
authors.forename: Kyo
authors.initials: K
authors.lastname: Noguchi
authors.forename: Kortaro
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D017241:MELAS Syndrome / Q000150:complications* / Q000000981:diagnostic imaging*; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D005442:Flumazenil; C063038:iomazenil