title: Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery.
abstract: Drug loading capacity is an important property for an ideal drug delivery system. However, the drug loading capacity of prepared pH-sensitive polymeric nanoparticles is usually low. To overcome this drawback, the electrospray method was used to prepare Eudragit L 100-55 nanoparticles with high drug loading capacity in one step. Omeprazole was selected as the model drug. The maximum loading capacity of nanoparticles was 43.21% by changing the mass ratio of drug to polymer, and the entrapment efficiency was nearly 100%. The prepared nanoparticle showed spherical or ellipsoidal morphology and the average diameter was about 300 nm. The pH-sensitive nanoparticle displayed pH-dependent release in vitro. In addition, a slight cytotoxicity was detected in the cytotoxicity study. The results indicated that electrospray is an easy, rapid and efficient technique for the preparation of high-loading pH-sensitive polymeric nanoparticles, and the pH-sensitive nanoparticle is a promising carrier for oral drug delivery.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Hao
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Wang
authors.forename: Bochu
authors.initials: B
authors.lastname: Wang
authors.forename: Jia
authors.initials: J
authors.lastname: Deng
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.forename: Junyu
authors.initials: J
authors.lastname: Liu
mesh_terms: D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D009853:Omeprazole / Q000737:chemistry / Q000633:toxicity; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011108:Polymers; D009853:Omeprazole
keywords: Cytotoxicity; Electrospray; High loading capacity; Nanoparticles; Oral drug delivery; pH-sensitive