title: A new anti-acetylcholinesterase α-pyrone meroterpene, arigsugacin I, from mangrove endophytic fungus Penicillium sp. sk5GW1L of Kandelia candel.
abstract: Arigsugacin I (1), a new α-pyrone meroterpene, along with two known compounds, arigsugacins F (2) and territrem B (3), were isolated from the mangrove endophytic fungus Penicillium sp. sk5GW1L from Kandelia candel. Their structures were identified through mass spectrometry and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. The absolute configuration of compound 2 was first reported by using X-ray copper radiation. Compounds 1-3 showed inhibitory activities against acetylcholinesterase with IC50 values of 0.64 ± 0.08 µM, 0.37 ± 0.11 µM, and 7.03 ± 0.20 nM, respectively.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xishan
authors.initials: X
authors.lastname: Huang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Ding
authors.forename: Ma
authors.initials: M
authors.lastname: Lin
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.forename: Huarong
authors.initials: H
authors.lastname: Huang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification; D043982:Rhizophoraceae / Q000382:microbiology*; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D002800:Cholinesterase Inhibitors; D011753:Pyrones; D013729:Terpenes; C000591003:arigsugacin I; D000110:Acetylcholinesterase