title: Peripartum anesthetic management of patients with Factor XI deficiency.
abstract: BACKGROUND
  Factor XI deficiency is predominantly found in the Ashkenazi Jewish population with a prevalence of 9%, but also seen in other ethnicities. Little information is available on obstetric anesthesia management in women with Factor XI deficiency. Therefore, we undertook a study to evaluate obstetric, anesthetic and perinatal outcomes in parturients with Factor XI deficiency.
  
  
  METHODS
  A retrospective study was conducted with chart reviews from 1996 to 2011 resulted in 74 women with Factor XI level deficiency. We compared anesthetic and obstetric management in parturients with low (≤30%) level of Factor XI to those with higher levels.
  
  
  RESULTS
  Ninety-one pregnancy outcomes were reviewed in these 74 women with Factor XI deficiency. Forty-three women had levels ≤30% in 46 labors while 31 women had levels >30% in 45 labors. Women with low levels of Factor XI were significantly more likely to receive FFP and less likely to receive neuroaxial anesthesia. There were no anesthetic complications and no difference in mode of delivery or neonatal outcomes.
  
  
  CONCLUSIONS
  This study is the first step in building a national database for anesthetic cases and outcomes of parturients with Factor XI deficiency. Further efforts must be made to provide safe analgesia for these women.
authors.forename: Alon
authors.initials: A
authors.lastname: Reuveni
authors.forename: Sharon
authors.initials: S
authors.lastname: Orbach-Zinger
authors.forename: Leonid A
authors.initials: LA
authors.lastname: Eidelman
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ginosar
authors.forename: Alexander
authors.initials: A
authors.lastname: Ioscovich
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000706:statistics & numerical data*; D005173:Factor XI Deficiency; D005260:Female; D006801:Humans; D008875:Middle Aged; D058725:Peripartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D055815:Young Adult