title: Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer.
abstract: In the present study, we report an association between gastric cancer and polymorphisms in NFKB1 (rs28362941 and rs78696119). We employed the PCR-SSCP method to detect gene polymorphisms in 479 gastric cancer cases and 880 controls. The rs28362941 del/del homozygote was significantly associated with gastric cancer development; in particular it was closely associated with diffuse type gastric cancer. The rs78696119 GG homozygote was also associated with the diffuse type of gastric cancer. In young subjects, both polymorphisms were significantly associated with the development of gastric cancer. In addition, both polymorphisms were related to tumor progression such as tumor invasion and lymph node metastasis. The inflammatory cell infiltration into non-cancerous gastric mucosa was greater in the subjects with the rs28362491 del/del or rs78696119 GG genotype when compared to those with the other genotypes. In conclusion, functional polymorphisms of NFKB1 are associated with an increased risk of gastric cancer; in particular they are closely associated with the development of diffuse type of gastric cancer via severe gastric inflammation. These polymorphisms also appear to be associated with gastric cancer progression.
authors.affiliation: Department of Gastroenterology, Kanazawa Medical University, Uchinada-machi, Ishikawa 920-029, Japan.
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Shiroeda
authors.forename: Kaho
authors.initials: K
authors.lastname: Yamada
authors.forename: Tomoe
authors.initials: T
authors.lastname: Nomura
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Ranji
authors.initials: R
authors.lastname: Hayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Toshimi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Takeo
authors.initials: T
authors.lastname: Shimasaki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Toshikuni
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kawada
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
mesh_terms: D000368:Aged; D063646:Carcinogenesis / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human