title: Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw.
abstract: OBJECTIVE
  This article covers the authors' experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals.
  
  
  METHODS
  A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol consisted of antimicrobial mouth rinses and systemic antibiotic administration according to the stage of the disease. Additional surgical debridement and sequestrectomy in combination with antimicrobial therapy was performed in two cases.
  
  
  RESULTS
  Complete healing was achieved in six patients. In two cases, satisfactory healing was noted. Stage of the disease was lowered and only a small area of asymptomatic necrotic bone of up to five mm in diameter persisted. Two patients developed a stable disease without progression. In one patient, the disease progressed to the third stage with osteonecrosis involving all quadrants of both jaws.
  
  
  CONCLUSIONS
  From these data it was concluded that conservative approach in the treatment of bisphosphonate-related osteonecrosis of the jaw led to symptom regression but was not curative. Surgical intervention, however, bears the risk of further progression of the osteonecrosis and must be carefully planned with respect to the patient's general health status and life expectancy. The treatment of bisphosphonate-related osteonecrosis of the jaw is generally difficult. For this reason, prevention plays a predominant role in the management of the disease.
authors.affiliation: Department of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Janovska
authors.affiliation: Department of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Radovan
authors.initials: R
authors.lastname: Mottl
authors.affiliation: Department of Dentistry, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic.
authors.forename: Radovan
authors.initials: R
authors.lastname: Slezak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000188:drug therapy* / Q000601:surgery; D050071:Bone Density Conservation Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy; D004164:Diphosphonates / Q000009:adverse effects; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage*; D009101:Multiple Myeloma / Q000188:drug therapy; D010024:Osteoporosis / Q000188:drug therapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D009067:Mouthwashes
keywords: BRONJ; bisphosphonates; jaw; osteonecrosis; treatment