title: Pituitary apoplexy associated with cabergoline therapy.
abstract: Pituitary apoplexy is a rare medical emergency which results from hemorrhage or infarction in the pituitary gland. One of the predisposing factors is treatment with dopamine agonists, especially bromocriptine. We report a 20-year-old Chinese man with prolactinoma who developed pituitary apoplexy 6 weeks after initiation of cabergoline. He was treated conservatively with supportive therapy, and recovered well with no loss of pituitary function. A literature search was conducted and a review of the reported patients with pituitary apoplexy during treatment with dopamine agonists is discussed.
authors.affiliation: Department of Endocrinology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. Electronic address: edwin_chng@ttsh.com.sg.
authors.forename: Edwin
authors.initials: E
authors.lastname: Chng
authors.forename: Rinkoo
authors.initials: R
authors.lastname: Dalan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D004873:Ergolines / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010899:Pituitary Apoplexy / Q000139:chemically induced* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy / Q000473:pathology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline
keywords: Bromocriptine; Cabergoline; Dopamine agonist; Pituitary apoplexy; Prolactinoma