title: Effect of Hibiscus sabdariffa Calices on Dyslipidemia in Obese Adolescents: A Triple-masked Randomized Controlled Trial.
abstract: BACKGROUND
  none declared.
  
  
  OBJECTIVE
  We aimed to evaluate the effects of Hibiscus sabdariffa (HS) calices on controlling dyslipidemia in obese adolescents.
  
  
  METHODS
  In this triple blind randomized placebo-controlled clinical trial which was registered in the Iranian registry for clinical trials (IRCT201109122306N2), 90 obese adolescents aged 12-18 years with documented dyslipidemia were randomly assigned in two groups of cases who received 2 grams of fine powdered calices of Hibiscus sabdariffa per day for one month and controls who received placebo powder with the same dietary and physical activity recommendations and duration of exposure. Full lipid profile and fasting blood sugar measured before and after the trial. Data were analyzed using multivariate general linear model.
  
  
  RESULTS
  Overall, 72 participants (mean age of 14.21±1.6, 35 boys) completed the trial. The two arms of the study (cases and controls) were not statistically different in terms of age, gender, weight, body mass index (BMI) and lipid profile before the trial. Serum total cholesterol, low density lipoprotein cholesterol and serum triglyceride showed a significant decrease in cases group but high density lipoprotein cholesterol level was not changed significantly.
  
  
  CONCLUSIONS
  It is concluded that Hibiscus sabdariffa calyces powder may have significant positive effects on lipid profile of adolescents which maybe attributed to its polyphenolic and antioxidant content. Further studies are needed on dose-response and formulation optimization.
authors.affiliation: Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences , Isfahan, Iran.
authors.forename: Ali Mohammad
authors.initials: AM
authors.lastname: Sabzghabaee
authors.forename: Ehsan
authors.initials: E
authors.lastname: Ataei
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghannadi
authors.forename: Rasool
authors.initials: R
authors.lastname: Soltani
authors.forename: Shirinsadat
authors.initials: S
authors.lastname: Badri
authors.forename: Shahin
authors.initials: S
authors.lastname: Shirani
keywords: Adolescents; Hibiscus sabdariffa L.; Metabolic syndrome; hyperlipidemia