title: Ethnic specificity of variants of the ESR1, HK3, BRSK1 genes and the 8q22.3 locus: no association with premature ovarian failure (POF) in Serbian women.
abstract: OBJECTIVE
  To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).
  
  
  METHODS
  Case-control genetic association study in 197 Serbian POF cases and 552 matched controls.
  
  
  RESULTS
  None of the SNPs found associated with POF in Chinese cohort were found to be associated in the Serbian sample.
  
  
  CONCLUSIONS
  In contrast to Han Chinese, no association was found between POF in Serbian women and any of the four tested loci: 8q22.3, HK3, ESR1 and BRSK1. This indicates that ethnically distinct populations may show differences in gene-regulating pathways and genes causing POF.
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Faculty of Medicine, University of Belgrade, Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Vujovic
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Li
authors.affiliation: Gynaecology Research Unit, University Hospitals of Leicester, United Kingdom.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Genetics, University of Leicester, Leicester, United Kingdom.
authors.forename: Raymond
authors.initials: R
authors.lastname: Dalgleish
authors.affiliation: Research and Global Programs March of Dimes Foundation, White Plains, NY, USA; Human & Molecular Genetics, Obstetrics and Gynecology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
authors.forename: Joe Leigh
authors.initials: JL
authors.lastname: Simpson
authors.affiliation: Faculty of Medicine, University of Belgrade, Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Maja
authors.initials: M
authors.lastname: Ivanisevic
authors.affiliation: Faculty of Medicine, University of Belgrade, Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Miomira
authors.initials: M
authors.lastname: Ivovic
authors.affiliation: Faculty of Medicine, University of Belgrade, Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Milina
authors.initials: M
authors.lastname: Tancic
authors.affiliation: Gynaecology Research Unit, University Hospitals of Leicester, United Kingdom. Electronic address: fa2@leicester.ac.uk.
authors.forename: Farook
authors.initials: F
authors.lastname: Al-Azzawi
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: chenzijiang@hotmail.com.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D015331:Cohort Studies; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008594:Menopause, Premature / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000208:ethnology / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D055771:Serbia; D055815:Young Adult
chemical_list: D047628:Estrogen Receptor alpha; D047908:Intracellular Signaling Peptides and Proteins; C523084:BRSK1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: 8q22.3; BRSK1; ESR1; HK3; Premature ovarian failure (POF)