title: [Economic evaluation of rheumathoid arthritis monotherapy with tocilizumab and adalimumab].
abstract: BACKGROUND
  Tocilizumab (TCZ) was superior to adalimumab (ADA), as monotherapy, in reducing signs and symptoms of adult rheumatoid arthritis (RA) when methotrexate (MTX) treatment is poorly tolerated or inappropriate. The aim of the study was to analyze the cost-effectiveness of TCZ vs ADA in these patients.
  
  
  METHODS
  Economic evaluation of the cost per response or remission of TCZ vs ADA from ADACTA (time horizon: 24 weeks). Clinical response criteria ACR or disease remission criteria, DAS28.
  
  
  CONCLUSIONS
  National Health System. The costs included (acquisition, administration and monitoring of medicines; € 2012) were obtained from Spanish sources. Simple univariate sensitivity analyzes were performed.
  
  
  RESULTS
  ACR20, ACR50 and ACR70 response rates with TCZ and ADA were obtained in 65% and 49.4% (p <0.01), 47.2% and 27.8% (p <0.01); and 32.5% and 17.9% (p <0.01) of patients, respectively. DAS28 remission occurred in 39.9% and 10.5%, respectively (p <0.0001). The cost per response was lower with TCZ than with ADA (ACR20: € 8,105 and € 11,553; ACR50: € 11,162 and € 20,529; ACR70: € 16,211 and € 31,882) respectively. The cost of DAS28 remission was € 13,204 and € 54,352, respectively. Treatment with TCZ was dominant (more effective, with lower costs vs ADA) in all scenarios analyzed.
  
  
  CONCLUSIONS
  According to this analysis, in Spain TCZ monotherapy is an efficient strategy vs ADA for treating RA patients intolerant to MTX or in which there is inappropriate response.
authors.affiliation: Hospital Virgen Macarena, Sevilla, España.
authors.forename: Federico
authors.initials: F
authors.lastname: Navarro Sarabia
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Blanco
authors.forename: José Ma
authors.initials: JM
authors.lastname: Álvaro Gracia
authors.forename: Juan A
authors.initials: JA
authors.lastname: García Meijide
authors.forename: José Luis
authors.initials: JL
authors.lastname: Poveda
authors.forename: Darío
authors.initials: D
authors.lastname: Rubio-Rodríguez
authors.forename: Carlos
authors.initials: C
authors.lastname: Rubio-Terrés
mesh_terms: D000068879:Adalimumab; D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000191:economics* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000191:economics* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000191:economics; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013030:Spain
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D000068879:Adalimumab; C502936:tocilizumab; D008727:Methotrexate