title: Acid indigestion in the endosome: linking signaling dysregulation to neurodevelopmental disorders.
abstract: The sodium-proton exchanger NHE6 contributes to proper endosomal acidification. NHE6 mutations are also linked to autism-related disorders. In this issue of Neuron, using NHE6-knockout mice, Ouyang et al. (2013) uncover how dysregulation of endosomal pH leads to disturbances in BDNF signaling and neuronal morphogenesis defects.
authors.affiliation: University of Virginia, Department of Neuroscience, 409 Lane Road, Charlottesville, VA 22908, USA.
authors.forename: Chan Choo
authors.initials: CC
authors.lastname: Yap
authors.forename: Bettina
authors.initials: B
authors.lastname: Winckler
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D009415:Nerve Net / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D020813:Receptor, trkB / Q000235:genetics*; D015398:Signal Transduction; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics*
chemical_list: C503961:NHE6 protein, mouse; D017923:Sodium-Hydrogen Exchangers; D020813:Receptor, trkB