title: Refractive and keratometric stability in high myopic LASIK with high-frequency femtosecond and excimer lasers.
abstract: OBJECTIVE
  To evaluate safety, efficacy, ergonomy, and refractive and keratometric stability in high myopia LASIK procedures using a novel femtosecond and excimer laser surgery platform.
  
  
  METHODS
  One hundred sixteen eyes in consecutive cases of high myopic LASIK ( ≥ -6.00 diopters [D]) with the Alcon-WaveLight FS200 femtosecond and EX500 excimer lasers (Alcon Laboratories, Fort Worth, TX) were evaluated preoperatively and postoperatively for the following parameters: refractive error, corrected distance visual acuity, uncorrected distance visual acuity, spherical equivalent correction, keratometry (with Placido topography and Scheimpflug tomography), and refractive astigmatism. Average follow-up time was 6.2 months (range: 3 to 12 months).
  
  
  RESULTS
  Postoperative average refractive error was -0.37, -0.43, and -0.25 D for the 3-, 6-, and 12-month period, compared to -7.67 ± 1.55 D preoperatively. At 3, 6, and 12 months postoperatively 94%, 96.3%, and 100% of eyes, respectively, were within 1.0 D defocus equivalent. Postoperative refractive astigmatism was -0.21, -0.21, -0.13 D for the 3-, 6-, and 12-month period compared to -1.07 ± 1.91 D preoperatively. The proportion of eyes with postoperative astigmatism within 0.25 D was 85.3%, 81.5%, and 100%, for the 3-, 6-, and 12-month visit, respectively. Keratometric stability was within 0.22 D after the 12-month visit. There was no epithelial ingrowth or diffuse lamellar keratitis in any case.
  
  
  CONCLUSIONS
  Clinical outcomes with this technique and technology appear to be promising in high level uncorrected visual rehabilitation of high myopia. There was small regression potential in the sample evaluated.
authors.forename: Anastasios John
authors.initials: AJ
authors.lastname: Kanellopoulos
authors.forename: George
authors.initials: G
authors.lastname: Asimellis
mesh_terms: D000293:Adolescent; D000328:Adult; D001251:Astigmatism / Q000503:physiopathology; D003319:Corneal Stroma / Q000601:surgery*; D019781:Corneal Topography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000503:physiopathology / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult