title: Gender differences in CMS and the effects of antidepressant venlafaxine in rats.
abstract: Gender differences in susceptibility to chronic mild stress (CMS) and effects of venlafaxine in rats have been investigated in the current study. Male and female SD rats were exposed to CMS or CMS plus chronic venlafaxine administration (10mg/kg, 21days) in order to study depressive behavior in rats. Rats were tested in open field test and sucrose preference test to figure out gender differences in behavior. Then serum corticosterone and the expression of FKBP5 in hippocampus of rats were detected to explore the possible mechanism. The results showed that the CMS impact on behavioral parameters and corticosterone levels and response to venlafaxine were gender dependent. Female rats appeared more vulnerable in the dysregulation of HPA axis to CMS. Venlafaxine treatment normalized depressive-like behavior in both gender. However, venlafaxine treated male rats exhibited better improved explore behavior and anhedonia. FKBP5 might be involved in the explanation of gender differences in CMS and venlafaxine treatment. Male and female rats respond differently to chronic stress and venlafaxine continuous treatment. This results have guiding meaning in design of trials related to stress induced depression.
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Xing
authors.affiliation: School of Pharmacy, Yantai University, Shandong 264003, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Hou
authors.affiliation: Shandong Luye Pharmaceutical Co. Ltd., Yantai, ShanDong 264003, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Lin
authors.affiliation: School of Pharmacy, Yantai University, Shandong 264003, PR China.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Tian
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address: liyuanbopharm@gmail.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
mesh_terms: D059445:Anhedonia / Q000187:drug effects; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003511:Cyclohexanols / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D012727:Sex Characteristics; D013315:Stress, Psychological / Q000188:drug therapy* / Q000523:psychology*; D022021:Tacrolimus Binding Proteins / Q000378:metabolism; D000069470:Venlafaxine Hydrochloride; D000099159:Tacrolimus Binding Protein 5
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003345:Corticosterone; D003511:Cyclohexanols; D022021:Tacrolimus Binding Proteins; D000069470:Venlafaxine Hydrochloride; D000099159:Tacrolimus Binding Protein 5
keywords: Antidepressant; FKBP5; Gender difference; Venlafaxine