title: Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery.
abstract: The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a matrix system. Matrix tablets weighing 250 mg were prepared by direct compression with 10-30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release.
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, University of Seville , Sevilla , Spain.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Campiñez
authors.forename: Ángela
authors.initials: Á
authors.lastname: Aguilar-de-Leyva
authors.forename: Cristina
authors.initials: C
authors.lastname: Ferris
authors.forename: M Violante
authors.initials: MV
authors.lastname: de Paz
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Galbis
authors.forename: Isidoro
authors.initials: I
authors.lastname: Caraballo
mesh_terms: D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry*; D055598:Chemical Phenomena; D003485:Cyanates / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004058:Diffusion; D004339:Drug Compounding; D005079:Excipients / Q000138:chemical synthesis / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007202:Indicators and Reagents / Q000737:chemistry; D017953:Isocyanates; D007700:Kinetics; D055595:Mechanical Phenomena; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013806:Theophylline / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry*; D014783:Viscosity
chemical_list: D063566:Biodegradable Plastics; D003485:Cyanates; D003692:Delayed-Action Preparations; D005079:Excipients; D007202:Indicators and Reagents; D017953:Isocyanates; D011140:Polyurethanes; D013607:Tablets; D014665:Vasodilator Agents; C015262:1,6-hexamethylene diisocyanate; C028914:triethylene glycol; D011092:Polyethylene Glycols; D013806:Theophylline