title: Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task.
abstract: Recent studies across several mammalian species have revealed a distributed network of cortical and subcortical brain regions responsible for sensorimotor decision making. Many of these regions have been shown to be interconnected with the pedunculopontine tegmental nucleus (PPTg), a brain stem structure characterized by neuronal heterogeneity and thought to be involved in several cognitive and behavioral functions. However, whether this structure plays a general functional role in sensorimotor decision making is unclear. We hypothesized that, in the context of a sensorimotor task, activity in the PPTg would reflect task-related variables in a similar manner as do the cortical and subcortical regions with which it is anatomically associated. To examine this hypothesis, we recorded PPTg activity in mice performing an odor-cued spatial choice task requiring a stereotyped leftward or rightward orienting movement to obtain a reward. We studied single-neuron activity during epochs of the task related to movement preparation, execution, and outcome (i.e., whether or not the movement was rewarded). We found that a substantial proportion of neurons in the PPTg exhibited direction-selective activity during one or more of these epochs. In addition, an overlapping population of neurons reflected movement direction and reward outcome. These results suggest that the PPTg should be considered within the network of brain areas responsible for sensorimotor decision making and lay the foundation for future experiments to examine how the PPTg interacts with other regions to control sensory-guided motor output.
authors.affiliation: Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: John A
authors.initials: JA
authors.lastname: Thompson
authors.forename: Gidon
authors.initials: G
authors.lastname: Felsen
mesh_terms: D000818:Animals; D003657:Decision Making; D008124:Locomotion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology; D009949:Orientation; D045042:Pedunculopontine Tegmental Nucleus / Q000166:cytology / Q000502:physiology*; D012201:Reward; D012903:Smell; D013647:Task Performance and Analysis
keywords: basal ganglia; decision making; pedunculopontine tegmental nucleus; sensorimotor