title: Microfabricated polymer-based neural interface for electrical stimulation/recording, drug delivery, and chemical sensing--development.
abstract: We present here a microfabricated, multi-functional neural interface with the ability to selectively apply electrical and chemical stimuli, while simultaneously monitoring both electrical and chemical activity in the brain. Such a comprehensive approach is required to understand and treat neuropsychiatric disorders, such as major depressive disorder (MDD), and to understand the mechanisms underlying treatments, such as pharmaceutical therapies and deep brain stimulation (DBS). The polymer-based, multi-functional neural interface is capable of electrical stimulation and recording, targeted drug delivery, and electrochemical sensing. A variety of different electrode and fluidic channel arrangements are possible with this fabrication process. Preliminary testing has shown the suitability of these neural interfaces for in vivo electrical stimulation and recording, as well as in vitro chemical sensing. Testing of the in vitro drug delivery and combined in vivo functionalities this neural interface are currently underway.
authors.forename: Angela
authors.initials: A
authors.lastname: Tooker
authors.forename: Teresa E
authors.initials: TE
authors.lastname: Madsen
authors.forename: Allison
authors.initials: A
authors.lastname: Yorita
authors.forename: Andrea
authors.initials: A
authors.lastname: Crowell
authors.forename: Kedar G
authors.initials: KG
authors.lastname: Shah
authors.forename: Sarah
authors.initials: S
authors.lastname: Felix
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: Satinderpall
authors.initials: S
authors.lastname: Pannu
authors.forename: Donald G
authors.initials: DG
authors.lastname: Rainnie
authors.forename: Vanessa
authors.initials: V
authors.lastname: Tolosa
mesh_terms: D001921:Brain / Q000502:physiology; D046690:Deep Brain Stimulation / Q000295:instrumentation; D003865:Major Depressive Disorder; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004558:Electric Stimulation / Q000295:instrumentation; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004567:Electrodes, Implanted; D004867:Equipment Design; D006801:Humans; D008328:Man-Machine Systems; D055616:Microtechnology; D009474:Neurons / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers