title: Four new C18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense.
abstract: Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg.
authors.affiliation: School of Agriculture, Yunnan University, Kunming 650091, PR China.
authors.forename: Da-Ke
authors.initials: DK
authors.lastname: Zhao
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Hong-Lian
authors.initials: HL
authors.lastname: Ai
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Zi
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Zhang
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Sheng-Chao
authors.initials: SC
authors.lastname: Yang
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Hua-Chun
authors.initials: HC
authors.lastname: Guo
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China. Electronic address: pharmsy@sina.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: College of Agriculture and Biotechnology, Yunnan Agricultural University, Kunming 650201, PR China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: chenjj@mail.kib.ac.cn.
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D019342:Acetic Acid; D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D031841:Aconitum / Q000737:chemistry*; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy
chemical_list: C000588655:8-O-ethylaconosine; D000700:Analgesics; D004365:Drugs, Chinese Herbal; D019342:Acetic Acid; D000157:Aconitine
keywords: Aconitum weixiense; Analgesic activity; Diterpenoid alkaloids; Ranunculaceae; Weisaconitines A–D