title: Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity.
abstract: Solitary chemosensory cells in the non-neuronal epithelium of the anterior nasal cavity have bitter taste cell-like molecular characteristics and are involved in the detection of noxious substances. Here, we demonstrate that Pou2f3/Skn-1a, which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells.
authors.affiliation: Monell Chemical Senses Center.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohmoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Junpei
authors.initials: J
authors.lastname: Yamashita
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Bachmanov
authors.forename: Junji
authors.initials: J
authors.lastname: Hirota
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D055786:Gene Knockout Techniques; D051379:Mice; D009296:Nasal Cavity / Q000166:cytology*; D050810:Octamer Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D050810:Octamer Transcription Factors; C084342:Pou2f3 protein, mouse