title: Decompressive craniectomy for management of traumatic brain injury: an update.
abstract: Decompressive craniectomy (DC) for the management of severe traumatic brain injury (TBI) has a long history but remains controversial. Although DC has been shown to improve both survival and functional outcome in patients with malignant cerebral infarctions, evidence of benefit in patients with TBI is decidedly more mixed. Craniectomy can clearly be life-saving in the presence of medically intractable elevations of intracranial pressure. Craniectomy also has been consistently demonstrated to reduce "therapeutic intensity" in the ICU, to reduce the need for intracranial-pressure-directed and brain-oxygen-directed interventions, and to reduce ICU length of stay. Still, the only randomized trial of DC in TBI failed to demonstrate any benefit. Studies of therapies for TBI, including hemicraniectomy, are challenging owing to the inherent heterogeneity in the pathophysiology observed in this disease. Craniectomy can be life-saving for patients with severe TBI, but many questions remain regarding its ideal application, and the outcome remains highly correlated with the severity of the initial injury.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania, 3400 Spruce Street, 3 Silverstein, Philadelphia, PA, 19104, USA.
authors.forename: Leif-Erik
authors.initials: LE
authors.lastname: Bohman
authors.forename: James M
authors.initials: JM
authors.lastname: Schuster
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000639:trends; D056424:Decompressive Craniectomy / Q000379:methods* / Q000639:trends*; D019468:Disease Management; D006801:Humans; D015337:Multicenter Studies as Topic / Q000639:trends; D016896:Treatment Outcome