title: [Histological and ultrastructural characteristics of myocardium in heart failure].
abstract: Endomyocardial biopsies performed in patients with various forms of cardiomyopathies (CMP) and chronic myocarditis in the presence of heart failure identified changes indicative of reduction of functioning cardiomyocytes (CMC) at the account of their destruction, dedifferentiation and inefficient hypertrophy". Energy apparatus of CMC was represented by large masses of destructed small mitochondria. Myofibrils were driven to periphery of CMC and appeared atrophic. Products of catabolism (lipofuscin, autophagous vacuoles, protein conglomerates) were accumulated in CMC. This led to impairment of CMC main function - to exert contraction. Reduction of number of capillary vessels per unit of myocardial cross-section area was also found. Discussion of problems of morphogenesis of the observed changes and of pathogenetic treatment is presented in the article.
authors.affiliation: Institute of Clinical Cardiology of Russian Cardiology Scientific and Production Center, ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Tsyplenkova
mesh_terms: D000328:Adult; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000150:complications / Q000473:pathology*; D001706:Biopsy; D009202:Cardiomyopathies / Q000145:classification / Q000150:complications / Q000473:pathology*; D006333:Heart Failure / Q000209:etiology / Q000473:pathology*; D006652:Histological Techniques / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000473:pathology / Q000648:ultrastructure; D009205:Myocarditis / Q000150:complications / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology / Q000648:ultrastructure