title: Takotsubo syndrome (or apical ballooning syndrome) secondary to Zolmitriptan.
abstract: Takotsubo syndrome (TS), also known as broken heart syndrome, is characterized by left ventricle apical ballooning with elevated cardiac biomarkers and electrocardiographic changes suggestive of an acute coronary syndrome (ie, ST-segment elevation, T wave inversions, and pathologic Q waves). We report a case of 54-year-old woman with medical history of mitral valve prolapse and migraines, who was admitted to the hospital for substernal chest pain and electrocardiogram demonstrated 1/2 mm ST-segment elevation in leads II, III, aVF, V5, and V6 and positive troponin I. Emergent coronary angiogram revealed normal coronary arteries with moderately reduced left ventricular ejection fraction with wall motion abnormalities consistent with TS. Detailed history obtained retrospectively revealed that the patient took zolmitriptan sparingly only when she had migraines. But before this event, she was taking zolmitriptan 2-3 times daily for several days because of a persistent migraine headache. She otherwise reported that she is quite active, rides horses, and does show jumping without any limitations in her physical activity. There was no evidence of any recent stress or status migrainosus. Extensive literature search revealed multiple cases of coronary artery vasospasm secondary to zolmitriptan, but none of the cases were associated with TS.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Westchester Medical Center, New York Medical College, NY.
authors.forename: Jalaj
authors.initials: J
authors.lastname: Garg
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: Srikala
authors.initials: S
authors.lastname: Devabhaktuni
authors.forename: Hasan
authors.initials: H
authors.lastname: Ahmad
mesh_terms: D002637:Chest Pain / Q000209:etiology; D017023:Coronary Angiography / Q000379:methods; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D058825:Serotonin 5-HT1 Receptor Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D054549:Takotsubo Cardiomyopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014363:Tryptamines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D023303:Oxazolidinones; D058825:Serotonin 5-HT1 Receptor Agonists; D014363:Tryptamines; C089750:zolmitriptan