title: Association between serum cystatin C levels and coronary slow flow.
abstract: We assessed the association between serum cystatin C (CysC) levels and coronary slow flow (CSF) phenomenon in patients who underwent coronary angiography. A total of 210 patients (mean age 55.6 ± 10.9 years; 100 females) were included. Patients were divided into 3 groups, (patients with CSF [group 2], with coronary artery disease [CAD; group 3], and without CAD [group 1]). Serum CysC levels in patients with CSF were significantly lower than those with and without CAD (912.5 ± 135.6, 820.4 ± 104.2, and 1343.4 ± 236.6 ng/mL in groups 1, 2, and 3, respectively; P < .001). Serum CysC levels correlated with the number of vessels with CSF and mean corrected thrombolysis in myocardial infarction frame count (Spearman correlation coefficient [r s] = .192, P < .001 and r s = .261, P < .001 respectively). In conclusion, patients with CSF have lower CysC levels; this could be a useful biomarker of CSF involvement in patients who undergo diagnostic coronary angiography.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey atasal01@gmail.com.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tasal
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacaksiz
authors.affiliation: Department of Cardiology, Istanbul Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ertas
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Seref
authors.initials: S
authors.lastname: Kul
authors.affiliation: Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Sari
authors.affiliation: Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Muhammed Emin
authors.initials: ME
authors.lastname: Dãœz
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Erdogan
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Sonmez
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Foundation University, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Goktekin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003326:Coronary Circulation; D055316:Cystatin C / Q000097:blood*; D015536:Down-Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C
keywords: coronary artery disease; coronary slow flow phenomenon; cystatin C