title: Controlled release of anticancer drug using graphene oxide as a drug-binding effector in konjac glucomannan/sodium alginate hydrogels.
abstract: In order to find new composite materials for the controlled release of drugs, a series of novel pH sensitive konjac glucomannan/sodium alginate (KGM/SA) and KGM/SA/graphene oxide (KGM/SA/GO) hydrogels were prepared, using GO as a drug-binding effector for anticancer drug loading and release. The hydrogels were characterized using Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The effects of component ratio and pH on the swelling properties of hydrogels were studied. The release amount of 5-fluorouracil (5-FU) incorporated into KGM/SA/GO-3 hydrogels was about 38.02% at pH 1.2 and 84.19% at pH 6.8 after 6 h and 12 h, respectively. Therefore, the release rate of 5-FU from the functionalized KGM/SA using GO could be effectively controlled, Go has a great potential to be a promising drug-binding effector for hydrogel functionalization in drug delivery.
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: chliu@swu.edu.cn.
authors.forename: Changhua
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shuai
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Cui
authors.affiliation: College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Nie
mesh_terms: D000464:Alginates / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008351:Mannans / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D008351:Mannans; D010087:Oxides; C022901:(1-6)-alpha-glucomannan; D006108:Graphite; D020723:Glucuronic Acid
keywords: Drug-binding effector; Graphene oxide; Konjac glucomannan; pH sensitive