title: Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome.
abstract: The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.
authors.affiliation: Department of Rheumatology & Biochemistry, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India ; Department of Biochemistry, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India.
authors.forename: Ghizal
authors.initials: G
authors.lastname: Fatima
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.forename: Siddharth Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Baby
authors.initials: B
authors.lastname: Anjum
authors.forename: Nar Singh
authors.initials: NS
authors.lastname: Verma
authors.forename: Puneet
authors.initials: P
authors.lastname: Kumar
authors.forename: Ragini
authors.initials: R
authors.lastname: Shrivastava
keywords: Circadian rhythm; Fibromyalgia syndrome; Interleukin-6; Tumor necrosis factor