title: Calcitonin gene-related peptide upregulates serum amyloid A synthesis through activation of interleukin-6.
abstract: We found that calcitonin gene-related peptide (CGRP) enhanced the expression of levels of serum amyloid A (SAA) and interleukin-6 (IL-6) in HepG2. In addition, CGRP-induced SAA1/2 mRNA expression was blocked by an anti-IL-6 neutralizing antibody in HepG2. These results suggest that CGRP promotes SAA synthesis through activation of IL-6 in human hepatocytes.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
authors.forename: Sho
authors.initials: S
authors.lastname: Matsui
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
mesh_terms: D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D015850:Interleukin-6; D012333:RNA, Messenger; D000685:Serum Amyloid A Protein; D015740:Calcitonin Gene-Related Peptide