title: Multimodality therapy for large cell neuroendocrine carcinoma of the thymus.
abstract: A case of large cell neuroendocrine carcinoma of the thymus successfully treated with chemoradiation, followed by extended resection under cardiopulmonary bypass, is reported. A 44-year-old man diagnosed with thymic large cell neuroendocrine carcinoma received induction chemoradiation therapy (3 cycles of cisplatin/etoposide and 45 Gy of hyperfractionated radiation) because of invasion to the aortic arch and pulmonary trunk. After radiographic partial response was noted, a radical resection under cardiopulmonary bypass was performed. Pathologic examination revealed no viable cells in the tumor. The patient is alive 3 years later, without recurrence. Aggressive multimodality therapy could be an option for thymic large cell neuroendocrine carcinoma.
authors.affiliation: Department of General Thoracic Surgery, Toneyama National Hospital, Osaka, Japan. Electronic address: naokoose@toneyama.go.jp.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ose
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shintani
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sawabata
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000328:Adult; D018287:Carcinoma, Large Cell / Q000628:therapy*; D018278:Carcinoma, Neuroendocrine / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D013953:Thymus Neoplasms / Q000628:therapy*
keywords: 13