title: Molecular neuropsychology: creation of test-specific blood biomarker algorithms.
abstract: BACKGROUND
  Prior work on the link between blood-based biomarkers and cognitive status has largely been based on dichotomous classifications rather than detailed neuropsychological functioning. The current project was designed to create serum-based biomarker algorithms that predict neuropsychological test performance.
  
  
  METHODS
  A battery of neuropsychological measures was administered. Random forest analyses were utilized to create neuropsychological test-specific biomarker risk scores in a training set that were entered into linear regression models predicting the respective test scores in the test set. Serum multiplex biomarker data were analyzed on 108 proteins from 395 participants (197 Alzheimer patients and 198 controls) from the Texas Alzheimer's Research and Care Consortium.
  
  
  RESULTS
  The biomarker risk scores were significant predictors (p < 0.05) of scores on all neuropsychological tests. With the exception of premorbid intellectual status (6.6%), the biomarker risk scores alone accounted for a minimum of 12.9% of the variance in neuropsychological scores. Biomarker algorithms (biomarker risk scores and demographics) accounted for substantially more variance in scores. Review of the variable importance plots indicated differential patterns of biomarker significance for each test, suggesting the possibility of domain-specific biomarker algorithms.
  
  
  CONCLUSIONS
  Our findings provide proof of concept for a novel area of scientific discovery, which we term 'molecular neuropsychology'.
authors.affiliation: Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, Tex., USA.
authors.forename: Sid E
authors.initials: SE
authors.lastname: O'Bryant
authors.forename: Guanghua
authors.initials: G
authors.lastname: Xiao
authors.forename: Robert
authors.initials: R
authors.lastname: Barber
authors.forename: C Munro
authors.initials: CM
authors.lastname: Cullum
authors.forename: Myron
authors.initials: M
authors.lastname: Weiner
authors.forename: James
authors.initials: J
authors.lastname: Hall
authors.forename: Melissa
authors.initials: M
authors.lastname: Edwards
authors.forename: Paula
authors.initials: P
authors.lastname: Grammas
authors.forename: Kirk
authors.initials: K
authors.lastname: Wilhelmsen
authors.forename: Rachelle
authors.initials: R
authors.lastname: Doody
authors.forename: Ramon
authors.initials: R
authors.lastname: Diaz-Arrastia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000544:Alzheimer Disease / Q000097:blood / Q000523:psychology; D015415:Biomarkers / Q000097:blood*; D003071:Cognition / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007360:Intelligence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009484:Neuropsychology / Q000379:methods*
chemical_list: D015415:Biomarkers