title: DNMT3B7 expression related to MENT expression and its promoter methylation in human lymphomas.
abstract: DNA methyltransferase (DNMT) 3B7 is the most expressed DNMT3B splice variant. It was reported that the loss of DNMT3B function led to overexpression of the MEthylated in Normal Thymocyes (MENT) and accelerated mouse lymphomagenesis. We investigated the DNMT3B7 expression and its relationship to MENT expression and promoter methylation in human lymphomas. DNMT3B7 and MENT expression were significantly (p<0.0001, p<0.01) higher in lymphomas than in non-malignant. Expression of DNMT3B7 and MENT were associated with MENT promoter hypomethylation. DNMT3B7 overexpression might interfere with the normal DNA methylation mechanism required for silencing the MENT proto-oncogene, and may accelerate human lymphomagenesis.
authors.affiliation: Graduate School of Health Sciences, Gunma University, Gunma, Japan. Electronic address: lobnakibsi@gmail.com.
authors.forename: Lobna
authors.initials: L
authors.lastname: Alkebsi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yohei
authors.initials: Y
authors.lastname: Osaki
authors.forename: Kunio
authors.initials: K
authors.lastname: Yanagisawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yokohama
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hattori
authors.forename: Hiromi
authors.initials: H
authors.lastname: Koiso
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Takeki
authors.initials: T
authors.lastname: Mitsui
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D019175:DNA Methylation / Q000502:physiology*; D000090205:DNA Methyltransferase 3A; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics*; D011401:Promoter Regions, Genetic; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*; D000097584:DNA Methyltransferase 3B
chemical_list: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D007527:Isoenzymes; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D000097584:DNA Methyltransferase 3B; C586427:C1orf56 protein, human; C000717967:DNMT3A protein, human; C000715470:MAS1 protein, human
keywords: DNMT3B7; Human lymphoma; MENT