title: Diterpene para-hydroquinone compounds derived from cryptoquinone inhibit adipocyte differentiation of mouse 3T3-L1 cells and activate the Nrf2/ARE pathway.
abstract: Cryptoquinone, an abietane-type diterpene para-quinone from the bark of Cryptomeria japonica has antifungal and cytotoxic activities, but its biological actions are largely unknown. In this study, we found that para-hydroquinone derivatives inhibited adipocyte differentiation. The actions might have been mediated, at least in part, by activation of the antioxidant-response element induction of phase 2 enzymes and increases in total glutathione.
authors.affiliation: Department of Welfare Engineering, Faculty of Engineering, Iwate University.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sasaki
authors.forename: Terumasa
authors.initials: T
authors.lastname: Tozawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugamoto
authors.forename: Yohichi
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Takumi
authors.initials: T
authors.lastname: Satoh
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry*; D006873:Hydroquinones / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D020218:Response Elements / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D004224:Diterpenes; D006873:Hydroquinones; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse; C031927:hydroquinone