title: Role of type 1 natural killer T cells in pulmonary immunity.
abstract: Mucosal sites are populated by a multitude of innate lymphoid cells and "innate-like" T lymphocytes expressing semiconserved T-cell receptors. Among the latter group, interest in type I natural killer T (NKT) cells has gained considerable momentum over the last decade. Exposure to NKT cell antigens is likely to occur continuously at mucosal sites. For this reason, and as they rapidly respond to stress-induced environmental cytokines, NKT cells are important contributors to immune and inflammatory responses. Here, we review the dual role of mucosal NKT cells during immune responses and pathologies with a particular focus on the lungs. Their role during pulmonary acute and chronic inflammation and respiratory infections is outlined. Whether NKT cells might provide a future attractive therapeutic target for treating human respiratory diseases is discussed.
authors.affiliation: 1] Cancer Immunology Program, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia [2] Sir Peter MacCallum Department of Oncology and Department of Pathology, University of Melbourne, Parkville, Victoria, Australia [3] Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille, Lille, France [4] Institut National de la Santé et de la Recherche Médicale, Lille, France [5] Centre National de la Recherche Scientifique, UMR 8204, Lille, France [6] Université Lille Nord de France, Lille, France [7] Institut Fédératif de Recherche 142, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Paget
authors.forename: F
authors.initials: F
authors.lastname: Trottein
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D007165:Immunosuppression Therapy; D016219:Immunotherapy, Adoptive; D008168:Lung / Q000276:immunology* / Q000382:microbiology; D009092:Mucous Membrane / Q000276:immunology* / Q000382:microbiology; D055611:Natural Killer T-Cells / Q000276:immunology*; D011014:Pneumonia / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000628:therapy
chemical_list: D016207:Cytokines