title: A monoclinic crystal form of casein kinase 1 δ.
abstract: Casein kinase 1 δ (CK1δ) is a regulatory enzyme in the mammalian circadian oscillator and represents a potential pharmacological target for modulating circadian rhythms. Crystal structures of four different polymorphs of CK1δ have previously been determined and this article reports the crystallization and structure determination of a new crystal form belonging to space group P21. Comparison of CK1δ crystal structures reveals few conformational differences within the C-terminal lobe, but more significant movements of the β-sheet region of the N-terminal lobe were observed.
authors.affiliation: Department of Chemistry, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Zeringo
authors.forename: Lea
authors.initials: L
authors.lastname: Murphy
authors.forename: Eric A
authors.initials: EA
authors.lastname: McCloskey
authors.forename: Loren
authors.initials: L
authors.lastname: Rohal
authors.forename: John J
authors.initials: JJ
authors.lastname: Bellizzi
mesh_terms: D000818:Animals; D055162:Biocatalysis; D048148:Casein Kinase Idelta / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D051379:Mice; D008958:Models, Molecular; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D040681:Structural Homology, Protein
chemical_list: D048148:Casein Kinase Idelta
keywords: casein kinase 1 δ; polymorphism