title: Genetic characterization of canine influenza A virus (H3N2) in Thailand.
abstract: In January 2012, several clinical cases of dogs with flu-like symptoms, including coughing, sneezing, nasal discharge, and fever, were reported in a small-animal hospital located in Bangkok, Thailand. One influenza A virus was identified and characterized as an avian-like influenza virus H3N2. The virus was named A/canine/Thailand/CU-DC5299/12. A phylogenetic analysis indicated that the canine virus belonged to an avian Eurasian lineage and was genetically related to the canine influenza viruses H3N2 from China and Korea. This canine virus displays a unique genetic signature with two amino acid insertions in the NA protein, which is similar to the canine influenza viruses from eastern China (Zhejiang and Jiangsu). This study constitutes the first report of H3N2 canine influenza virus infection in a small-animal hospital in Thailand.
authors.affiliation: Center of Excellence for Emerging and Re-emerging Infectious Diseases in Animals, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors.forename: Napawan
authors.initials: N
authors.lastname: Bunpapong
authors.forename: Nutthawan
authors.initials: N
authors.lastname: Nonthabenjawan
authors.forename: Supassama
authors.initials: S
authors.lastname: Chaiwong
authors.forename: Ratanaporn
authors.initials: R
authors.lastname: Tangwangvivat
authors.forename: Supanat
authors.initials: S
authors.lastname: Boonyapisitsopa
authors.forename: Waleemas
authors.initials: W
authors.lastname: Jairak
authors.forename: Ranida
authors.initials: R
authors.lastname: Tuanudom
authors.forename: Duangduean
authors.initials: D
authors.lastname: Prakairungnamthip
authors.forename: Sanipa
authors.initials: S
authors.lastname: Suradhat
authors.forename: Roongroje
authors.initials: R
authors.lastname: Thanawongnuwech
authors.forename: Alongkorn
authors.initials: A
authors.lastname: Amonsin
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005260:Female; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D008297:Male; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009439:Neuraminidase / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013785:Thailand; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase