title: Topical gels of lidocaine HCl using cashew gum and Carbopol 940: preparation and in vitro skin permeation.
abstract: The present study was attempted to prepare novel topical gels of 4% lidocaine HCl using cashew gum and Carbopol 940. The prepared gels were evaluated for pH, viscosity, and in vitro skin permeation through excised porcine skin. The pH of these topical gels was found within the range of 5.98-6.06; whereas, the viscosity was found 4.58 × 10(6) to 4.88 × 10(6) cps. The in vitro skin permeation from these gels showed permeation flux range, 851.34 ± 9.16 to 1568.15 ± 14.03 μg/cm(2)/h. The highest permeation flux (1568.15 ± 14.03 μg/cm(2)/h) was observed, when 0.01% menthol was added, which was higher than that of the marketed 4% lidicaine HCl topical gel (1355.41 ± 10.92 μg/cm(2)/h). These topical gels found best-fit with Korsmeyer-Peppas model and almost the super case-II transport mechanism. The stability study revealed that these gels were physically stable without occurrence of syneresis.
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
authors.forename: Biswarup
authors.initials: B
authors.lastname: Das
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.forename: Upendranath
authors.initials: U
authors.lastname: Nanda
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000279:Administration, Cutaneous; D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D004337:Drug Carriers; D005782:Gels / Q000737:chemistry*; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010539:Permeability; D012867:Skin / Q000378:metabolism; D013552:Swine; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; C006903:carbopol 940; D008012:Lidocaine
keywords: Carbopol 940; Cashew gum; Gel; Lidocaine HCl; Skin permeation; Topical application