title: Preliminary study of non-invasive shock wave treatment of capsular contracture after breast implant: animal model.
abstract: The incidence rate of capsular contracture after breast implant is about 8% to 12%. Patients would feel extremely uncomfortable after scar formation. Administering oral medications (such as vitamin E and Zafirlukast tablets, etc.) or invasive breast capsulectomy surgery was commonly used for capsular contracture repair in clinical therapy. However, the therapeutic effect is still under investigation. Shock waves can be used to remove soft connective tissue in clinical applications. It has been widely used in orthopedics and rehabilitation. No related research paper about shock wave treatment of capsular contracture has been published yet. It might provide another choice for capsular contracture repair. In order to simulate breast implantation, two silica-gel bags filled with normal saline were implanted into New Zealand rabbit's thighs bilaterally as an animal model. Six weeks later, daily shock wave treatment on the right thigh was performed for six weeks after capsular contractures were formed, while the other thigh was used as a control. Then, magnetic resonance imaging (MRI) was used to compare the difference between treated and un-treated thighs. Afterwards, pathological sections were analyzed to confirm the findings. It has been demonstrated that shock wave treatments are capable of changing the structure and composition of capsular contractures. The structure of scar became myxoid changed or collagen deposition of scar decreased after shock wave treatment, hence, the formation of scars decreased. Increased myxoid and decreased collagen deposition has also been found.
authors.forename: Yu-Chiuan
authors.initials: YC
authors.lastname: Wu
authors.forename: Jo-Chi
authors.initials: JC
authors.lastname: Jao
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Yang
authors.forename: Hsiang-Sheng
authors.initials: HS
authors.lastname: Wang
authors.forename: Chun-Hsien
authors.initials: CH
authors.lastname: Wu
authors.forename: Po-Chou
authors.initials: PC
authors.lastname: Chen
mesh_terms: D000818:Animals; D018427:Breast Implants / Q000009:adverse effects*; D003094:Collagen / Q000378:metabolism; D005260:Female; D019220:High-Energy Shock Waves; D057910:Implant Capsular Contracture / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008321:Mammary Glands, Animal / Q000473:pathology; D023421:Models, Animal; D011817:Rabbits
chemical_list: D003094:Collagen