title: Early structural changes during spontaneous closure of idiopathic full-thickness macular hole determined by optical coherence tomography: a case report.
abstract: BACKGROUND
  Spontaneous closure of an idiopathic full-thickness macular hole has been reported to occasionally occur. However, the cells involved in plugging the macular hole have not been determined conclusively. We aimed to report the early structural changes that occur during a spontaneous closure of an idiopathic full-thickness macular hole determined by spectral-domain optical coherence tomography.
  
  
  METHODS
  A 71-year-old Japanese man with an idiopathic full-thickness macular hole and subclinical posterior vitreous detachment in the left eye was followed. Three weeks after the identification of the macular hole, optical coherence tomography showed tissue that protruded from the interior wall of the macular hole at the level of the external limiting membrane toward the center of the macular hole. Five months after the first examination, he returned with improvements of his visual symptoms, and the macular hole was closed by a thin retinal tissue which included the restored external limiting membrane that bridged across the macular hole. However, the inner segment/outer segment junction line was not intact and the fovea was detached. Two months later, optical coherence tomography showed an almost normal foveal configuration with an essentially restored inner segment/outer segment junction line and foveal reattachment.
  
  
  CONCLUSIONS
  Our results suggest that Müller cells proliferate and/or extend at the level of the end of the external limiting membrane to form a tissue bridge across the macular hole associated with the external limiting membrane restoration first of all. This leads to the adhesion of other retinal layers and resolution of the foveal detachment.
authors.affiliation: Unoki Eye Clinic, Harara 1-7-15, Kagoshima 890-0026, Japan. akiko@m2.kufm.kagoshima-u.ac.jp.
authors.forename: Akiko
authors.initials: A
authors.lastname: Okubo
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Unoki
authors.forename: Keita
authors.initials: K
authors.lastname: Yamakiri
authors.forename: Munefumi
authors.initials: M
authors.lastname: Sameshima
authors.forename: Taiji
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D005123:Eye / Q000473:pathology; D006801:Humans; D008297:Male; D012167:Retinal Perforations / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014822:Vitreous Body / Q000473:pathology