title: Synthesis of α-aminonitriles with benzimidazolic and theophyllinic backbones using the Strecker reaction.
abstract: An example of the application of the Strecker reaction in the synthesis of a new class of α-aminonitriles with benzimidazole and theophylline backbones has been developed. For the synthesis of these compounds, first 4-hydroxybenzaldehyde was reacted with 1,3- and 1,5-dibromides/epibromohydrin to produce the corresponding bromo-substituted aldehydes. Then, benzimidazole/theophylline was reacted with the latter to generate the related benzimidazolic/theophyllinic aldehydes. Finally, the Strecker reactions of the synthetic benzimidazolic and theophyllinic aldehydes with different amines afforded the target products.
authors.affiliation: Department of Chemistry, College of Sciences, Shiraz University , Shiraz 71454, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Khalafi-Nezhad
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Divar
authors.forename: Farhad
authors.initials: F
authors.lastname: Panahi
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013806:Theophylline / Q000737:chemistry*
chemical_list: D001547:Benzaldehydes; D001562:Benzimidazoles; D009570:Nitriles; D013806:Theophylline; C011483:4-hydroxybenzaldehyde