title: Clinical differences in Clostridium difficile infection based on age: a multicenter study.
abstract: Advancing age is a well-known risk factor for Clostridium difficile infection (CDI). However, age-specific clinical differences in CDI are uncertain. A retrospective comparative analysis was performed based on age in 1367 patients with CDI in Korea. Most clinical features were similar in the two age groups studied, however malignancy was more common in the older group (age ≥ 65 y) (p < 0.001), while chemotherapy and transplantation were more common in the younger group (age < 65 y) (p < 0.001). Endoscopic examinations were more commonly performed in the older group (p = 0.010), which had a high positive predictive value (88.3%). More patients recovered from CDI without specific antibiotic treatment in the younger group than in the older group (p < 0.001). Although advancing age is an important risk factor for CDI, the clinical features of younger patients are similar to those of the older patient population.
authors.affiliation: From Inje University College of Medicine.
authors.forename: Hyung Hun
authors.initials: HH
authors.lastname: Kim
authors.forename: You Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Joo Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Kim
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Young-Sook
authors.initials: YS
authors.lastname: Park
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Song
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Shin
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Byong Duk
authors.initials: BD
authors.lastname: Ye
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Eun
authors.forename: Kang-Moon
authors.initials: KM
authors.lastname: Lee
authors.forename: Sang Heon
authors.initials: SH
authors.lastname: Lee
authors.forename: Byung-Ik
authors.initials: BI
authors.lastname: Jang
authors.forename: Sung-Ae
authors.initials: SA
authors.lastname: Jung
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Cheon
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Choi
authors.forename: Kyuchan
authors.initials: K
authors.lastname: Huh
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007723:Korea; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents