title: Evaluation of headache and regional cerebral flood flow in patients with migraine.
abstract: OBJECTIVE
  The aim of this study is to observe the abnormalities of regional cerebral blood flow (rCBF) in migraine patients and to evaluate its relation to the severity of the headache in patients with migraine.
  
  
  METHODS
  The rCBF imaging was done on 19 patients with migraine and 15 normal controls using single-photon emission computed tomography (SPECT). The abnormal character of cerebral perfusion function was analyzed with Statistical Parametric Mapping (SPM) software, and the headache grade of patients was evaluated with the headache severity measuring scale.
  
  
  RESULTS
  The results of SPM analysis demonstrated a decreased rCBF on both sides of the frontal and temporal lobes, left parietal lobe, and right occipital lobe (P < 0.001), and increased rCBF focus on the left prefrontal lobe and right temporal lobe (P < 0.001). The headache scores in migraineurs were correlated to the rCBF on the bilateral temporal lobes and right frontal lobe (P < 0.001).
  
  
  CONCLUSIONS
  The migraineurs had lower rCBF at the frontal and temporal lobes, and the lower rCBF was correlated to the degree of headache.
authors.affiliation: From the *Departments of Nuclear Medicine, †Psychology, and ‡Neurology, Third Hospital Affiliated Sun Yat-sen University, Guangzhou, China.
authors.forename: Mu-hua
authors.initials: MH
authors.lastname: Cheng
authors.forename: Sheng-lin
authors.initials: SL
authors.lastname: Wen
authors.forename: Han Jian
authors.initials: HJ
authors.lastname: Zhou
authors.forename: Bian
authors.initials: B
authors.lastname: Lian-Fang
authors.forename: Jian-fang
authors.initials: JF
authors.lastname: Li
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Xie
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008881:Migraine Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000502:physiology*