title: A neuronal network model with simplified tonotopicity for tinnitus generation and its relief by sound therapy.
abstract: Tinnitus is the perception of sound in the ears or in the head where no external source is present. Sound therapy is one of the most effective techniques for tinnitus treatment that have been proposed. In order to investigate mechanisms of tinnitus generation and the clinical effects of sound therapy, we have proposed conceptual and computational models with plasticity using a neural oscillator or a neuronal network model. In the present paper, we propose a neuronal network model with simplified tonotopicity of the auditory system as more detailed structure. In this model an integrate-and-fire neuron model is employed and homeostatic plasticity is incorporated. The computer simulation results show that the present model can show the generation of oscillation and its cessation by external input. It suggests that the present framework is promising as a modeling for the tinnitus generation and the effects of sound therapy.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nagashino
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Kinouchi
authors.forename: Ali A
authors.initials: AA
authors.lastname: Danesh
authors.forename: Abhijit S
authors.initials: AS
authors.lastname: Pandya
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D013016:Sound; D014012:Tinnitus / Q000628:therapy*