title: AA amyloidosis in a polyarteritis nodosa patient treated with tocilizumab.
abstract: Amyloid A (AA) (secondary) amyloidosis represents a severe complication of chronic inflammatory diseases. Since pathogenic mechanisms point to the central role of interleukin 6 (IL-6) in the process of amyloid AA generation, IL-6 blockade seems an attractive therapeutic option. We report a case of a patient with polyarteritis nodosa complicated by AA amyloidosis treated with tocilizumab.
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana , Ljubljana , Slovenia .
authors.forename: Alojzija
authors.initials: A
authors.lastname: Hočevar
authors.forename: Boris
authors.initials: B
authors.lastname: Lestan
authors.forename: Snežna Sodin
authors.initials: SS
authors.lastname: Šemrl
authors.forename: Katja
authors.initials: K
authors.lastname: Lakota
authors.forename: Nika
authors.initials: N
authors.lastname: Kojc
authors.forename: Nataša
authors.initials: N
authors.lastname: Potočnik
authors.forename: Matija
authors.initials: M
authors.lastname: Tomšič
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy* / Q000378:metabolism; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D010488:Polyarteritis Nodosa / Q000188:drug therapy* / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000685:Serum Amyloid A Protein; C502936:tocilizumab; D008775:Methylprednisolone