title: Cervical IL-6 and pIGFBP-1 and the prediction of neonatal outcome in symptomatic preterm labour.
abstract: OBJECTIVE
  To evaluate the use of cervical Interleukin 6 (IL-6) and phosphorylated Insulin Growth Binding Protein 1 (pIGFBP1) in the prediction of adverse neonatal outcome.
  
  
  METHODS
  Prospective observational study including women between 24 and 34 weeks of gestation. One hundred and twelve cervical samples for IL-6 and pIFBP1 were taken. Neonatal outcome variables were birth weight, Apgar scores at 1st/5th minute, gestational age at delivery, admission to neonatal unit (NNU) and to neonatal intensive care unit (NICU), composite neonatal morbidity (NCM) and neonatal mortality.
  
  
  RESULTS
  Cervical IL-6 concentrations (pg/ml) were higher in neonates admitted to NNU and NICU versus non-admission, and women developing chorioamnionitis versus non-chorioamnionitis (mean ± standard deviation: 168.1 ± 205.2 versus 62.3 ± 72.4, p < 0.01; 262.1 ± 298 versus 92 ± 127.6, p < 0.01, and 564 ± 213 versus 93.4 ± 126.4, p < 0.05, respectively). In the NCM group, the IL-6 concentrations were higher compared to the non-NCM (181.7 ± 224 versus 84.1 ± 117.7, p < 0.05). In the preterm births <37 weeks, no differences were found for NCM, admission to NICU/NNU. The logistic regression analysis, showed cervical IL-6 and examination-to-delivery interval as predictors of NCM in the univariate analysis. However, the only independent marker of adverse neonatal outcome was the examination-to-delivery interval.
  
  
  CONCLUSIONS
  Adverse neonatal outcome is associated with increased cervical IL-6 concentrations.
authors.affiliation: Obstetrics Department and.
authors.forename: Maia
authors.initials: M
authors.lastname: Brik
authors.forename: Marta
authors.initials: M
authors.lastname: Aguar
authors.forename: Ana
authors.initials: A
authors.lastname: Valiente
authors.forename: Alfredo
authors.initials: A
authors.lastname: Perales
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002584:Cervix Uteri / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis / Q000378:metabolism*; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D010766:Phosphorylation; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D015850:Interleukin-6
keywords: Cervical markers; neonatal morbidity; prediction; preterm birth