title: Prognosis and ICU outcome of systemic vasculitis.
abstract: BACKGROUND
  Systemic vasculitis may cause life threatening complications requiring admission to an intensive care unit (ICU). The aim of this study was to evaluate outcomes of systemic vasculitis patients admitted to the ICU and to identify prognosis factors.
  
  
  METHODS
  During a ten-year period, records of 31 adult patients with systemic vasculitis admitted to ICUs (median age: 63 y.o, sex ratio M/F: 21/10, SAPS II: 40) were reviewed including clinical and biological parameters, use of mechanical ventilation, catecholamine or/and dialysis support. Mortality was assessed and data were analyzed to identify predictive factors of outcome.
  
  
  RESULTS
  Causes of ICU admissions were active manifestation of vasculitis (n = 19), septic shock (n = 8) and miscellaneous (n = 4). Sixteen patients (52%) died in ICU. By univariate analysis, mortality was associated with higher SOFA (p = 0.006) and SAPS II (p = 0.004) scores. The need for a catecholamine support or/and a renal replacement therapy, and the occurrence of an ARDS significantly worsen the prognosis. By multivariate analysis, only SAPS II (Odd ratio: 1.16, 95% CI [1.01; 1.33]) and BVAS scores (Odd ratio: 1.16, 95% CI = [1.01; 1.34]) were predictive of mortality.
  
  
  CONCLUSIONS
  The mortality rate of severe vasculitis requiring an admission to ICU was high. High levels of SAPS II and BVAS scores at admission were predictive of mortality.
authors.forename: Patrice
authors.initials: P
authors.lastname: Befort
authors.forename: Philippe
authors.initials: P
authors.lastname: Corne
authors.forename: Thomas
authors.initials: T
authors.lastname: Filleron
authors.forename: Boris
authors.initials: B
authors.lastname: Jung
authors.forename: Christian
authors.initials: C
authors.lastname: Bengler
authors.forename: Olivier
authors.initials: O
authors.lastname: Jonquet
authors.affiliation: Department of Intensive Care Unit, Lapeyronie University Hospital, 191 Avenue du Doyen G, Giraud, Montpellier 34090, France. k-klouche@chu-montpellier.fr.
authors.forename: Kada
authors.initials: K
authors.lastname: Klouche