title: Bronchoscopic intrabullous autologous blood instillation: a novel approach for the treatment of giant bullae.
abstract: The current standard therapy for patients with giant bullae is surgical bullectomy; however, high operative risk and comorbidities preclude surgical procedures in many patients. Autologous blood instilled directly into bullae can induce an inflammatory reaction, leading to scarring, fibrosis, and ultimately volume loss. We have treated 5 patients with this minimally invasive approach as day-case procedures using moderate sedation. Three of the 5 patients had shrinkage of the bullae, leading to large and clinically meaningful improvements in lung function, exercise capacity, and quality of life 3 months after treatment.
authors.affiliation: NIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, United Kingdom; Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom. Electronic address: zzoumot@doctors.org.uk.
authors.forename: Zaid
authors.initials: Z
authors.lastname: Zoumot
authors.affiliation: NIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, United Kingdom; Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, United Kingdom.
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Kemp
authors.affiliation: Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom.
authors.forename: Cielito
authors.initials: C
authors.lastname: Caneja
authors.affiliation: Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom.
authors.forename: Suveer
authors.initials: S
authors.lastname: Singh
authors.affiliation: NIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, United Kingdom; Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom.
authors.forename: Pallav L
authors.initials: PL
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D001768:Blister / Q000473:pathology / Q000628:therapy*; D001804:Blood Transfusion, Autologous; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: 11