title: Synthesis and characterization of PEG-iron oxide core-shell composite nanoparticles for thermal therapy.
abstract: In this study, core-shell nanoparticles were developed to achieve thermal therapy that can ablate cancer cells in a remotely controlled manner. The core-shell nanoparticles were prepared using atomic transfer radical polymerization (ATRP) to coat iron oxide (Fe3O4) nanoparticles with a poly(ethylene glycol) (PEG) based polymer shell. The iron oxide core allows for the remote heating of the particles in an alternating magnetic field (AMF). The coating of iron oxide with PEG was verified through Fourier transform infrared spectroscopy and thermal gravimetric analysis. A thermoablation (55°C) study was performed on A549 lung carcinoma cells exposed to nanoparticles and over a 10 min AMF exposure. The successful thermoablation of A549 demonstrates the potential use of polymer coated particles for thermal therapy.
authors.affiliation: Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wydra
authors.forename: Anastasia M
authors.initials: AM
authors.lastname: Kruse
authors.forename: Younsoo
authors.initials: Y
authors.lastname: Bae
authors.forename: Kimberly W
authors.initials: KW
authors.lastname: Anderson
authors.forename: J Zach
authors.initials: JZ
authors.lastname: Hilt
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000628:therapy; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D011108:Polymers; D011092:Polyethylene Glycols; D052203:Ferrosoferric Oxide
keywords: Atom transfer radical polymerization; Magnetic nanoparticles; Thermal therapy