title: Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles.
abstract: The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.
authors.affiliation: Ion Beam Centre, University of Surrey, Guildford, Surrey GU2 7XH, UK. j.c.jeynes@surrey.ac.uk.
authors.forename: J Charles G
authors.initials: JC
authors.lastname: Jeynes
authors.forename: Christopher
authors.initials: C
authors.lastname: Jeynes
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Merchant
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Kirkby
mesh_terms: D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D008954:Models, Biological
chemical_list: D006046:Gold