title: The seed and soil hypothesis revisited: current state of knowledge of inherited genes on prognosis in breast cancer.
abstract: The crucial event in the course of malignancies such as breast cancer is its metastatic spread from the primary tumor of origin to distant organs. The natural history of a tumor is determined by the expression of its genes, and in this sense, knowledge has advanced dramatically in recent decades. However, much less is known about the role that the patient plays in the behavior of a tumor. In this article, we review the evidence regarding the genetic background of the host in metastatic tumor dissemination, providing information from epidemiological studies as well as from animal models and human studies. Undoubtedly, the elucidation of possible interpersonal variability in susceptibility to developing metastases would significantly contribute to improve management of cancer patients.
authors.affiliation: Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Campus Teatinos s/n, 29010 Málaga, Spain. Electronic address: nuriaribelles@gmail.com.
authors.forename: Nuria
authors.initials: N
authors.lastname: Ribelles
authors.forename: Angela
authors.initials: A
authors.lastname: Santonja
authors.forename: Bella
authors.initials: B
authors.lastname: Pajares
authors.forename: Casilda
authors.initials: C
authors.lastname: Llácer
authors.forename: Emilio
authors.initials: E
authors.lastname: Alba
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008207:Lymphatic Metastasis; D008487:Medical History Taking; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D064726:Triple Negative Breast Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast cancer; Gene expression; Genetic background; Metastasis; Polymorphism; Tumor stroma