title: The effect of periodontal treatment on C-reactive protein: A clinical study.
abstract: BACKGROUND
  Chronic periodontitis in amultifactorial inflammatory disease which is caused by various microorganisms. Many studies have found close association between chronic periodontitis and C-reactive protein (CRP). CRPis an inflammatory marker which increases in all inflammatory condition.
  
  
  OBJECTIVE
  The present clinical study was designed to show the effect of periodontal treatment on the CRP levels of gingival crevicular fluid and to determine the effect of nonsurgical therapy in minimizing the CRP levels in chronic generalized periodontitis.
  
  
  METHODS
  Gingival crevicular fluid was collected using a micro capillary pipette that was hand calibrated at every 1 mm till 10 mm, from selected sites in the subjects on the 1st, 14th and 45th days.
  
  
  CONCLUSIONS
  Decreased CRP levels of gingival crevicular fluid were observed at the end of the study. There was a 37% reduction in probing pocket depth and 45% gain in clinical attachment level and a reduction of about 57% after 14 days and 90% reduction of CRP levels in gingival crevicular fluid after 45 days. Thus, the results show that the presence of CRP level is more significant in gingival crevicular fluid and confirms the underlying inflammatory component of the disease activity in chronic periodontitis.
authors.affiliation: Department of Periodontics, Karnavati School of Dentistry, Uvarsad, Gandhinagar, Gujarat, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.forename: Samir
authors.initials: S
authors.lastname: Shah
authors.forename: Shilpa
authors.initials: S
authors.lastname: Budhiraja
authors.forename: Khushboo
authors.initials: K
authors.lastname: Desai
authors.forename: Chirag
authors.initials: C
authors.lastname: Shah
authors.forename: Dhaval
authors.initials: D
authors.lastname: Mehta
keywords: C-reactive protein; GCF; periodontitis