title: Automated method for extraction of lung tumors using a machine learning classifier with knowledge of radiation oncologists on data sets of planning CT and FDG-PET/CT images.
abstract: We have developed an automated method for extraction of lung tumors using a machine learning classifier with knowledge of radiation oncologists on data sets of treatment planning computed tomography (CT) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT images. First, the PET images were registered with the treatment planning CT images through the diagnostic CT images of PET/CT. Second, six voxel-based features including voxel values and magnitudes of image gradient vectors were derived from each voxel in the planning CT and PET /CT image data sets. Finally, lung tumors were extracted by using a support vector machine (SVM), which learned 6 voxel-based features inside and outside each true tumor region determined by radiation oncologists. The results showed that the average DSCs for 3 and 6 features for three cases were 0.744 and 0.899, and thus the SVM may need 6 features to learn the distinguishable characteristics. The proposed method may be useful for assisting treatment planners in delineation of the tumor region.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Arimura
authors.forename: Ze
authors.initials: Z
authors.lastname: Jin
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shioyama
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakamura
authors.forename: Taiki
authors.initials: T
authors.lastname: Magome
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001331:Automation; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019359:Knowledge; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D060388:Support Vector Machine; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18