title: ROBUSTNESS OF SIGNALING GRADIENT IN DROSOPHILA WING IMAGINAL DISC.
abstract: Quasi-stable gradients of signaling protein molecules (known as morphogens or ligands) bound to cell receptors are known to be responsible for differential cell signaling and gene expressions. From these follow different stable cell fates and visually patterned tissues in biological development. Recent studies have shown that the relevant basic biological processes yield gradients that are sensitive to small changes in system characteristics (such as expression level of morphogens or receptors) or environmental conditions (such as temperature changes). Additional biological activities must play an important role in the high level of robustness observed in embryonic patterning for example. It is natural to attribute observed robustness to various type of feedback control mechanisms. However, our own simulation studies have shown that feedback control is neither necessary nor sufficient for robustness of the morphogen decapentaplegic (Dpp) gradient in wing imaginal disc of Drosophilas. Furthermore, robustness can be achieved by substantial binding of the signaling morphogen Dpp with nonsignaling cell surface bound molecules (such as heparan sulfate proteoglygans) and degrading the resulting complexes at a sufficiently rapid rate. The present work provides a theoretical basis for the results of our numerical simulation studies.
authors.affiliation: Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University Beijing, 100084, P.R. China.
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Lei
authors.forename: Frederic Y M
authors.initials: FY
authors.lastname: Wan
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Lander
authors.forename: Qing
authors.initials: Q
authors.lastname: Nie
keywords: Morphogen gradient; mathematical modeling; nonlinear boundary value problem; robustness