title: Suspected hypothyroid-associated neuropathy in a female rottweiler dog.
abstract: A 7-year-old, 46-kg spayed female rottweiler dog was presented with sudden onset of disorientation, bilateral convergent strabismus, and enophthalmos. Diagnostic workup revealed hypothyroid-associated cranial neuropathy. Symptoms abated considerably upon treatment with levothyroxine-sodium (T4) at an initial dose of 800 μg/kg body weight (BW), PO, q12h, which was reduced 3 days later to 600 μg/kg BW, q12h due to severe agitation and panting. Two weeks later the dosage of the levothyroxine-sodium (T4) was reduced to 400 μg/kg BW in the morning and 600 μg/kg BW in the evening. Eight weeks after the initial presentation, the dog had recovered with only mild convergent strabismus in the right eye. This is the first case report of suspected hypothyroid-associated neuropathy resulting in these symptoms.
authors.affiliation: Department of Companion Animals and Horses, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
authors.forename: James Oliver
authors.initials: JO
authors.lastname: Rushton
authors.forename: Michael
authors.initials: M
authors.lastname: Leschnik
authors.forename: Barbara
authors.initials: B
authors.lastname: Nell
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D015841:Enophthalmos / Q000209:etiology / Q000662:veterinary; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D013285:Strabismus / Q000209:etiology / Q000662:veterinary; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013974:Thyroxine