title: Asterixis related to gabapentin intake: a case report and review.
abstract: Asterixis has been reported as a side effect of toxic and metabolic abnormalities. The current literature contains very little evidence of gabapentin-related neurotoxicity. Our observations reveal that neurotoxic side effects of gabapentin use may be seen even when dose adjustments are made for patients with mild-to-moderate renal dysfunction. Clinical vigilance for possible neurotoxic effects of gabapentin therapy in patients with renal dysfunction is warranted.
authors.affiliation: University of Tennessee Health Sciences Center, Memphis, TN. wahbam7@yahoo.com.
authors.forename: Mervat
authors.initials: M
authors.lastname: Wahba
authors.forename: Olga
authors.initials: O
authors.lastname: Waln
mesh_terms: D000368:Aged; D000588:Amines / Q000009:adverse effects* / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects* / Q000627:therapeutic use*; D020820:Dyskinesias / Q000209:etiology*; D000077206:Gabapentin; D006801:Humans; D006987:Hypesthesia / Q000188:drug therapy*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D011115:Polyneuropathies / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects* / Q000627:therapeutic use*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin