title: A physiologic biomarker for cerebral amyloid angiopathy.
abstract: Cerebral amyloid angiopathy (CAA), a common small-vessel disease of older adults characterized by accumulation of amyloid-β in leptomeningeal and cortical blood vessels, is a well-established cause of intracerebral hemorrhage.(1) Recent years have seen the emergence of clinical research reports establishing associations between CAA, ischemic brain injury, and vascular cognitive impairment (VCI). CAA patients had a higher load of chronic microvascular white matter hyperintensities (WMH), small infarcts, as well as a high degree of WMH progression.(2,3) A more recent report showed that vascular amyloid load strongly correlated with ischemic WMH in CAA.(4.)
authors.affiliation: From the Department of Neurology, Massachusetts General Hospital, Boston.
authors.forename: M Edip
authors.initials: ME
authors.lastname: Gurol
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
mesh_terms: D015415:Biomarkers; D001921:Brain / Q000098:blood supply; D016657:Cerebral Amyloid Angiopathy / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D015415:Biomarkers