title: Acute alcohol intoxication, diffuse axonal injury and intraventricular bleeding in patients with isolated blunt traumatic brain injury.
abstract: OBJECTIVE
  The influence of blood alcohol level (BAL) on outcome remains unclear. This study investigated the relationships between BAL, type and number of diffuse axonal injury (DAI), intraventricular bleeding (IVB) and 6-month outcome.
  
  
  METHODS
  This study reviewed 419 patients with isolated blunt traumatic brain injury. First, it compared clinical and radiological characteristics between patients with good recovery and disability. Second, it compared BAL among DAI lesions. Third, it evaluated the correlation between the BAL and severity of IVB, number of DAI and corpus callosum injury lesions.
  
  
  RESULTS
  Regardless of BAL, older age, male gender, severe Glasgow Coma Scale score (<9), abnormal pupil, IVB and lesion on genu of corpus callosum were significantly related to disability. There were no significant differences between the BAL and lesions of DAI. Simple regression analysis revealed that there were no significant correlation between BAL and severity of IVB, number of DAI and corpus callosum injury lesions.
  
  
  CONCLUSIONS
  Acute alcohol intoxication was not associated with type and number of DAI lesion, IVB and disability. This study suggested that a specific type of traumatic lesion, specifically lesion on genu of corpus callosum and IVB, might be more vital for outcome.
authors.affiliation: Department of Neurosurgery and.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Shinoda
authors.forename: Motoharu
authors.initials: M
authors.lastname: Fujii
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Murakata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000435:Alcoholic Intoxication / Q000150:complications* / Q000453:epidemiology; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D020202:Cerebral Hemorrhage, Traumatic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology*; D020833:Diffuse Axonal Injury / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D004185:Disability Evaluation; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D015601:Injury Severity Score; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology