title: Akt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis.
authors.affiliation: Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. ding.wei@mayo.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Tait D
authors.initials: TD
authors.lastname: Shanafelt
authors.forename: Connie E
authors.initials: CE
authors.lastname: Lesnick
authors.forename: Charles
authors.initials: C
authors.lastname: Erlichman
authors.forename: Jose F
authors.initials: JF
authors.lastname: Leis
authors.forename: Charla
authors.initials: C
authors.lastname: Secreto
authors.forename: Traci R
authors.initials: TR
authors.lastname: Sassoon
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Call
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Bowen
authors.forename: Michael
authors.initials: M
authors.lastname: Conte
authors.forename: Shaji
authors.initials: S
authors.lastname: Kumar
authors.forename: Neil E
authors.initials: NE
authors.lastname: Kay
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D000069461:Bendamustine Hydrochloride; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004357:Drug Synergism; D006575:Heterocyclic Compounds, 3-Ring / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018906:Antineoplastic Agents, Alkylating; D016207:Cytokines; D006575:Heterocyclic Compounds, 3-Ring; C548887:MK 2206; D009588:Nitrogen Mustard Compounds; D000069461:Bendamustine Hydrochloride; D051057:Proto-Oncogene Proteins c-akt
keywords: Akt; B cell receptor; chronic lymphocytic leukaemia; cytokine