title: [Cathepsin L cysteine protease from Taenia solium: its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis].
abstract: Taenia solium is a plane helminth responsible for taeniasis and human cysticercosis, the latter being the result of the consumption of infective eggs. Cysticerci can develop in different human tissues, often in the central nervous system, causing neurocysticercosis (NCC). For the diagnosis of NCC, an adequate interpretation of clinical data, neuroimaging results and serological tests are required. However, serological tests could be improved by developing candidate antigens able to increase their sensibility and specificity. In the last years, a series of surface and secretory proteins of T. solium essential for the parasite-host interaction have been described. One of these families is cathepsin L cysteine proteases, which have a predominant role in the development and survival of the parasite. They take part in the tissue invasion, immune response evasion, excystation and encystment of cysticercus. They are considered potential antigens for the immunodiagnosis of neurocysticercosis.
authors.affiliation: Laboratorio de Bioinformática y Biología molecular, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Nancy
authors.initials: N
authors.lastname: León
authors.forename: Carlos
authors.initials: C
authors.lastname: Padilla
authors.forename: Mónica
authors.initials: M
authors.lastname: Pajuelo
authors.forename: Patricia
authors.initials: P
authors.lastname: Sheen
authors.forename: Mirko
authors.initials: M
authors.lastname: Zimic
mesh_terms: D000818:Animals; D056668:Cathepsin L / Q000032:analysis / Q000502:physiology*; D006801:Humans; D007159:Immunologic Tests; D020019:Neurocysticercosis / Q000175:diagnosis* / Q000276:immunology*; D041201:Taenia solium / Q000201:enzymology / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D056668:Cathepsin L