title: A simple gas exchange model predicting arterial oxygen content for various FiO2 levels.
abstract: The application of mechanical ventilation is a life-saving routine therapy that allows the patient to overcome the physiological impact of surgeries, trauma or critical illness by ensuring vital oxygenation and carbon dioxide removal. Above a certain level of minute ventilation (usually set to ensure acceptable carbon dioxide removal and oxygenation) oxygenation is only marginally affected by a further increase in minute ventilation. Thus, oxygenation is predominantly influenced by inspiratory oxygen fraction (FiO2) Usually, finding the appropriate setting is a trial-and-error procedure, as the clinician is unaware of the exact value that needs to be set in order to reach the desired arterial oxygen partial pressures (PaO2) in the patient.
authors.forename: Jörn
authors.initials: J
authors.lastname: Kretschmer
authors.forename: Tobias
authors.initials: T
authors.lastname: Becher
authors.forename: Axel
authors.initials: A
authors.lastname: Riedlinger
authors.forename: Dirk
authors.initials: D
authors.lastname: Schädler
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiler
authors.forename: Knut
authors.initials: K
authors.lastname: Möller
mesh_terms: D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000737:chemistry; D003196:Computer Graphics; D006801:Humans; D008962:Models, Theoretical; D010100:Oxygen / Q000737:chemistry*; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012119:Respiration; D012121:Respiration, Artificial / Q000379:methods*; D014584:User-Computer Interface; D012122:Ventilators, Mechanical
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen