title: Nanostructured lipid carriers as a delivery system of biochanin A.
abstract: The aim of this study was to explore the nanostructured lipid carriers as a delivery system of biochanin A so as to supply a method to improve its bioavailability. Biochanin A-loaded nanostructured lipid carriers (BCA-NLCs) were prepared by the method of emulsion-evaporation and low temperature solidification. Pharmacokinetics was carried out in rats upon oral administration at a dose of 10 mg/kg. BCA-NLC showed spherical formulation and had mean diameter 174.68±0.96 nm, zeta potential -20.9±0.8 mv and entrapment efficiency 97.36±0.14%. DSC and XRD studies indicated that BCA was not in crystal state in NLC. In in vitro release study, the BCA from BCA-NLC exhibited a biphasic release pattern with burst release initially and sustained release afterwards. BCA-NLC showed higher AUC value and circulated in blood for a longer time than BCA suspension. The studies demonstrated that NLC could be a potential delivery system for BCA to improve bioavailability.
authors.affiliation: Department of Pharmacy, Anhui University of Chinese Medicine , Hefei , China .
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Hailin
authors.initials: H
authors.lastname: Cheng
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Shixin
authors.initials: S
authors.lastname: Dong
authors.forename: Dianlei
authors.initials: D
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004655:Emulsions; D019833:Genistein / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D019833:Genistein; C004541:biochanin A