title: Lipid-lowering drugs associated with slower motor decline in the elderly adults.
abstract: BACKGROUND
  Vascular risk factors contribute to motor decline in the elderly persons. We investigated the relationship between lipid-lowering drugs (LLDs) use and decline in walking speed (WS) in older adults.
  
  
  METHODS
  Data on 4,009 community-dwelling men and women, aged ≥65 years at baseline, are drawn from the Dijon (France) center of the Three-City study. "Fast" WS was assessed over 6 m at baseline and at 4, 6, 8, and 10 years of follow-up. Mixed linear models were used to determine the relationship between LLDs and change in WS over the follow-up.
  
  
  RESULTS
  At baseline, 1,295 (32%) participants used LLDs (statins, n = 643; fibrates, n = 652); mean fast WS was 152.9cm/s and not significantly different between LLDs users and nonusers. In models adjusted for age, sex, cholesterol level, and other covariates, WS decline was 25% slower in LLDs users (difference with nonusers: 0.58cm/s/y, 95% CI: 0.30, 0.86; p < .001). Both fibrates and statins were associated with slower decline, but only the effect of statins was robust in analyses that took missing values into account. The beneficial effect was more pronounced in those on LLDs continuously over the follow-up.
  
  
  CONCLUSIONS
  Fast WS declined less in those on LLDs, suggesting that the effect of LLDs, statins in particular, extend beyond that on cardiovascular disease in the elderly persons. However, these effects were modest and their clinical relevance is unclear.
authors.affiliation: Memory Center of Lariboisiere Hospital, 200 rue du Faubourg Saint-Denis, 75010 Paris, France. julien.dumurgier@inserm.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Dumurgier
authors.forename: Archana
authors.initials: A
authors.lastname: Singh-Manoux
authors.forename: Béatrice
authors.initials: B
authors.lastname: Tavernier
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D058607:Fibric Acids / Q000627:therapeutic use*; D005602:France; D005684:Gait / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D013997:Time Factors
chemical_list: D058607:Fibric Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Epidemiology.; Gait; Lipid-lowering drugs; Motor function; Statins