title: Coating with artificial matrices from collagen and sulfated hyaluronan influences the osseointegration of dental implants.
abstract: Dental implants are an established therapy for oral rehabilitation. High success rates are achieved in healthy bone, however, these rates decrease in compromised host bone. Coating of dental implants with components of the extracellular matrix is a promising approach to enhance osseointegration in compromised peri-implant bone. Dental titanium implants were coated with an artificial extracellular matrix (aECM) consisting of collagen type I and either one of two regioselectively low sulfated hyaluronan (sHA) derivatives (coll/sHA1Δ6s and coll/sHA1) and compared to commercial pure titanium implants (control). After extraction of the premolar teeth, 36 implants were inserted into the maxilla of 6 miniature pigs (6 implants per maxilla). The healing periods were 4 and 8 weeks, respectively. After animal sacrifice, the samples were evaluated histomorphologically and histomorphometrically. All surface states led to a sufficient implant osseointegration after 4 and 8 weeks. Inflammatory or foreign body reactions could not be observed. After 4 weeks of healing, implants coated with coll/sHA1Δ6s showed the highest bone implant contact (BIC; coll/sHA1Δ6s: 45.4%; coll/sHA1: 42.2%; control: 42.3%). After 8 weeks, a decrease of BIC could be observed for coll/sHA1Δ6s and controls (coll/sHA1Δ6s: 37.3%; control: 31.7 %). For implants coated with coll/sHA1, the bone implant contact increased (coll/sHA1: 50.8%). Statistically significant differences could not be observed. Within the limits of the current study, aECM coatings containing low sHA increase peri-implant bone formation around dental implants in maxillary bone compared to controls in the early healing period.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Medical Faculty "Carl Gustav Carus", Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany, matthias.schulz@uniklinikum-dresden.de.
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Schulz
authors.forename: Paula
authors.initials: P
authors.lastname: Korn
authors.forename: Bernd
authors.initials: B
authors.lastname: Stadlinger
authors.forename: Ursula
authors.initials: U
authors.lastname: Range
authors.forename: Stephanie
authors.initials: S
authors.lastname: Möller
authors.forename: Jana
authors.initials: J
authors.lastname: Becher
authors.forename: Matthias
authors.initials: M
authors.lastname: Schnabelrauch
authors.forename: Ronald
authors.initials: R
authors.lastname: Mai
authors.forename: Dieter
authors.initials: D
authors.lastname: Scharnweber
authors.forename: Uwe
authors.initials: U
authors.lastname: Eckelt
authors.forename: Vera
authors.initials: V
authors.lastname: Hintze
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D015921:Dental Implants; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008422:Materials Testing; D008437:Maxilla / Q000033:anatomy & histology / Q000601:surgery; D023421:Models, Animal; D016348:Osseointegration; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D006820:Hyaluronic Acid; D003094:Collagen; D014025:Titanium