title: Fatty acids, coumarins and polyphenolic compounds of Ficus carica L. cv. Dottato: variation of bioactive compounds and biological activity of aerial parts.
abstract: Leaves, bark and woody part of Ficus carica L. cultivar Dottato collected in different months were examined to assess their chemical composition, antioxidant activity and phototoxicity on C32 human melanoma cells after UVA irradiation. The phytochemical investigation revealed different composition in the coumarin, fatty acid, polyphenol and flavonoid content. The second harvest of leaves and the first harvest of the bark possessed the highest antiradical activity with IC50 values of 64.00 ± 0.59 and 67.00 ± 1.09 μg/mL, respectively. Harvest III of leaves showed the best inhibition of lipid peroxidation (IC50 = 1.48 ± 0.04 μg/mL). Leaf samples of F. carica showed also the best antiproliferative activity in comparison with bark and woody part of F. carica.
authors.affiliation: a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , I-87036 Rende (CS) , Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Marrelli
authors.forename: Giancarlo A
authors.initials: GA
authors.lastname: Statti
authors.forename: Rosa
authors.initials: R
authors.lastname: Tundis
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichini
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D003374:Coumarins / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D003374:Coumarins; D005227:Fatty Acids; D005419:Flavonoids; D010851:Picrates; D059808:Polyphenols; C004931:1,1-diphenyl-2-picrylhydrazyl