title: Single-cell model of prokaryotic cell cycle.
abstract: One of the recognized prokaryotic cell cycle theories is Cooper-Helmstetter (CH) theory which relates start of DNA replication to particular (initiation) cell mass, cell growth and division. Different aspects of this theory have been extensively studied in the past. In the present study CH theory was applied at single cell level. Universal equations were derived for different cell parameters (cell mass and volume, surface area, DNA amount and content) depending on constructivist cell cycle parameters (unit mass, replication and division times, cell age, cell cycle duration) based on selected growth laws of cell mass (linear, exponential). The equations derived can be integrated into single-cell models for the analysis and design of bacterial cells.
authors.affiliation: Tallinn University of Technology, Department of Chemistry, Akadeemia tee 15, 12618 Tallinn, Estonia; Competence Centre of Food and Fermentation Technologies, Akadeemia tee 15a, 12618 Tallinn, Estonia.
authors.forename: Kristo
authors.initials: K
authors.lastname: Abner
authors.affiliation: Tallinn University of Technology, Department of Chemistry, Akadeemia tee 15, 12618 Tallinn, Estonia; Competence Centre of Food and Fermentation Technologies, Akadeemia tee 15a, 12618 Tallinn, Estonia.
authors.forename: Tõnis
authors.initials: T
authors.lastname: Aaviksaar
authors.affiliation: Competence Centre of Food and Fermentation Technologies, Akadeemia tee 15a, 12618 Tallinn, Estonia; Tallinn University of Technology, Department of Food Processing, Ehitajate tee 5, 19086 Tallinn, Estonia.
authors.forename: Kaarel
authors.initials: K
authors.lastname: Adamberg
authors.affiliation: Tallinn University of Technology, Department of Chemistry, Akadeemia tee 15, 12618 Tallinn, Estonia; Competence Centre of Food and Fermentation Technologies, Akadeemia tee 15a, 12618 Tallinn, Estonia. Electronic address: raivo@kbfi.ee.
authors.forename: Raivo
authors.initials: R
authors.lastname: Vilu
mesh_terms: D000818:Animals; D018533:Biomass; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D048429:Cell Size; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D004247:DNA / Q000032:analysis; D004261:DNA Replication / Q000502:physiology; D016678:Genome; D008954:Models, Biological; D011387:Prokaryotic Cells / Q000166:cytology*
chemical_list: D004247:DNA
keywords: Cell mass growth law; Cooper-Helmstetter cell cycle theory; Initiation mass; Single-cell model