title: [Significance of selenium in the pathogenesis and therapy of cardiovascular diseases and those requiring intensive care].
abstract: Selenium deficiency results in profound changes in cellular defence mechanisms against oxidative stress, which plays an important role in the development of cardiovascular disease and the associated risk factors. Increased formation and decreased elimination of reactive oxygen radicals contribute to the complicated mechanisms of sepsis and related disorders. Use of selenium in prevention and treatment of the above mentioned conditions is not a new idea, but controversial data were published in relation to both fields recently. The aim of the present review is to summarize the most important results related to this area.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt. 98. 4032.
authors.forename: György
authors.initials: G
authors.lastname: Koszta
authors.forename: Béla
authors.initials: B
authors.lastname: Fülesdi
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000401:mortality; D009202:Cardiomyopathies / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D003384:Coxsackievirus Infections / Q000453:epidemiology / Q000209:etiology; D003422:Critical Care / Q000379:methods / Q000592:standards / Q000639:trends; D016638:Critical Illness; D019587:Dietary Supplements; D019353:Endemic Diseases; D029822:Enterovirus B, Human / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D005060:Europe / Q000453:epidemiology; D006801:Humans; D018384:Oxidative Stress; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use*; D018805:Sepsis / Q000378:metabolism; D014131:Trace Elements / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D012643:Selenium
keywords: Keshan disease; Keshan-betegség; SIRS; selenium; selenium substitution; sepsis; szelén; szelénszubsztitúció; szepszis