title: Exploring QSARs of the interaction of flavonoids with GABA (A) receptor using MLR, ANN and SVM techniques.
abstract: Quantitative Structure-Activity Relationship (QSAR) models for binding affinity constants (log Ki) of 78 flavonoid ligands towards the benzodiazepine site of GABA (A) receptor complex were calculated using the machine learning methods: artificial neural network (ANN) and support vector machine (SVM) techniques. The models obtained were compared with those obtained using multiple linear regression (MLR) analysis. The descriptor selection and model building were performed with 10-fold cross-validation using the training data set. The SVM and MLR coefficient of determination values are 0.944 and 0.879, respectively, for the training set and are higher than those of ANN models. Though the SVM model shows improvement of training set fitting, the ANN model was superior to SVM and MLR in predicting the test set. Randomization test is employed to check the suitability of the models.
authors.affiliation: Faculty of Pharmacy, Al-Quds University , Jerusalem , Palestine and.
authors.forename: Omar
authors.initials: O
authors.lastname: Deeb
authors.forename: Basheerulla
authors.initials: B
authors.lastname: Shaik
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Agrawal
mesh_terms: D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology*; D016014:Linear Models; D015394:Molecular Structure; D016571:Neural Networks, Computer; D021281:Quantitative Structure-Activity Relationship; D011963:Receptors, GABA-A / Q000378:metabolism*; D060388:Support Vector Machine
chemical_list: D005419:Flavonoids; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A
keywords: ANN; GABA (A) receptor; SVM; flavanoids; machine learning methods