title: A model-based control protocol for transition from ICU to HDU: Robustness analysis.
abstract: The robustness of a model-based control protocol as a less intensive TGC protocol using insulin Glargine for provision of basal insulin is simulated in this study. To quantify the performance and robustness of the protocol to errors, namely physiological variability and sensor errors, an in-silico Monte Carlo analysis is performed. Actual patient data from Christchurch Hospital, New Zealand were used as virtual trial patients.
authors.forename: Normy N
authors.initials: NN
authors.lastname: Razak
authors.forename: J Geoffrey
authors.initials: JG
authors.lastname: Chase
authors.forename: Fatanah M
authors.initials: FM
authors.lastname: Suhaimi
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Shaw
authors.forename: Ummu
authors.initials: U
authors.lastname: Jamaluddin
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting / Q000493:pharmacokinetics; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009010:Monte Carlo Method
chemical_list: D001786:Blood Glucose; D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine