title: Common variant of FTO gene, rs9939609, and obesity in Pakistani females.
abstract: Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, height, waist circumference, hip circumference, and blood pressure (BP) were measured. BMI and waist-to-hip ratio (WHR) were calculated. Levels of fasting blood glucose (FBG), insulin, leptin, and leptin receptors were measured by enzyme linked immunosorbent assay (ELISA), and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. The results showed association of FTO gene, rs9939609, with obesity in females (>18 years of age). FTO minor allele increased the risk of obesity by 2.8 times (95% CI = 1.3-6.0) in females. This allele showed association with body weight, BMI, waist circumference, hip circumference, WHR, BP, plasma FBG levels, HOMA-IR, plasma insulin levels, and plasma leptin levels. In conclusion, FTO gene, rs9939609, is associated with BMI and risk of obesity in adult Pakistani females. Association of rs9939609 variant with higher FBG, plasma insulin, and leptin levels indicates that this polymorphism may disturb the metabolism in adult females and predispose them to obesity and type 2 diabetes. However, the above-mentioned findings were not seen in children or males.
authors.affiliation: Department of Physiology and Cell Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore-54600, Pakistan ; Department of Physiology, Shalamar Medical and Dental College, Shalimar Link Road, Mughalpura, Lahore-54840, Pakistan.
authors.forename: Adeela
authors.initials: A
authors.lastname: Shahid
authors.forename: Sobia
authors.initials: S
authors.lastname: Rana
authors.forename: Shahid
authors.initials: S
authors.lastname: Saeed
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.forename: Nasir
authors.initials: N
authors.lastname: Afzal
authors.forename: Saqib
authors.initials: S
authors.lastname: Mahmood
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D001786:Blood Glucose / Q000235:genetics*; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000473:pathology; D010154:Pakistan; D011506:Proteins / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human