title: Cerebrospinal fluid biomarkers of Alzheimer's disease in Chinese patients: a pilot study.
abstract: In view of the paucity of data on cerebrospinal fluid (CSF) biomarkers in Chinese patients, we evaluated the validity of tau, phosphorylated tau 181 (p-tau-181), amyloid β 42 (Aβ42), and Aβ40 proteins in Chinese patients with Alzheimer's disease (AD). We recruited 24 patients with AD, 12 nondemented controls, and 12 patients with non-AD dementia. We found the CSF levels of Aβ42, tau, p-tau, Aβ42-tau, and Aβ42-p-tau ratios, except the Aβ40 protein level, were significantly different among the 3 groups of patients. Patients with AD had higher levels of CSF tau and p-tau but lower levels of Aβ42 proteins, Aβ42-tau, and Aβ42-p-tau ratios than the nondemented controls. In the diagnosis of AD versus nondementia, the sensitivity and specificity of the ratios of Aβ42-tau and Aβ42-p-tau were 96% and 83% versus 92% and 83%, respectively. Only the Aβ42-p-tau ratio showed satisfactory sensitivity and specificity in the diagnosis of AD versus other dementia.
authors.affiliation: 1Division of Geriatrics, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: Yat Fung
authors.initials: YF
authors.lastname: Shea
authors.forename: Leung-Wing
authors.initials: LW
authors.lastname: Chu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Wing-Man
authors.initials: WM
authors.lastname: Li
authors.forename: Oi Yee
authors.initials: OY
authors.lastname: Lin
authors.forename: May N Y
authors.initials: MN
authors.lastname: Chan
authors.forename: Aimin
authors.initials: A
authors.lastname: Xu
authors.forename: Rachel
authors.initials: R
authors.lastname: Wong
authors.forename: Tip Yin
authors.initials: TY
authors.lastname: Ho
authors.forename: Kin Wah
authors.initials: KW
authors.lastname: Liu
authors.forename: Joyce
authors.initials: J
authors.lastname: Ha
authors.forename: T W
authors.initials: TW
authors.lastname: Daniel
authors.forename: You-Qiang
authors.initials: YQ
authors.lastname: Song
authors.forename: Karen S
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D044466:Asian People; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003704:Dementia / Q000134:cerebrospinal fluid / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D010865:Pilot Projects; D012680:Sensitivity and Specificity; D016875:tau Proteins / Q000134:cerebrospinal fluid* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins
keywords: Alzheimer’s disease; CSF; Chinese; biomarkers