title: Ultra-compliant neural probes are subject to fluid forces during dissolution of polymer delivery vehicles.
abstract: Ultra-compliant neural probes implanted into tissue using a molded, biodissolvable sodium carboxymethyl cellulose (Na-CMC)-saccharide composite needle delivery vehicle are subjected to fluid-structure interactions that can displace the recording site of the probe with respect to its designed implant location. We applied particle velocimetry to analyze the behavior of ultra-compliant structures under different implantation conditions for a range of CMC-based materials and identified a fluid management protocol that resulted in the successful targeted depth placement of the recording sites.
authors.forename: Wassim Ferose
authors.initials: WF
authors.lastname: Habeeb Rakuman
authors.forename: Xiao Chuan
authors.initials: XC
authors.lastname: Ong
authors.forename: H Serhat
authors.initials: HS
authors.lastname: Tetikol
authors.forename: R
authors.initials: R
authors.lastname: Khilwani
authors.forename: X Tracy
authors.initials: XT
authors.lastname: Cui
authors.forename: O Burak
authors.initials: OB
authors.lastname: Ozdoganlar
authors.forename: Gary K
authors.initials: GK
authors.lastname: Fedder
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Gilgunn
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002417:Cattle; D005947:Glucose / Q000008:administration & dosage; D055595:Mechanical Phenomena; D008856:Microscopy, Fluorescence; D009339:Needles; D061848:Optical Imaging; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D012995:Solubility; D014741:Video Recording
chemical_list: D011108:Polymers; D005947:Glucose; D002266:Carboxymethylcellulose Sodium