title: Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA).
abstract: The aim of the present study was to examine whether interconnected porous hydroxyapatite ceramics (IP-CHA) could be used as bone substitute for implant treatment in reconstructive surgery. We firstly assessed if surround of the titanium surface placed into granular or block-type IP-CHA can observe new bone formation in a rabbit bone defect model. Subsequently, osseointegration and stability of titanium implant inserted into block-type IP-CHA was investigated in a rabbit onlay graft model. Direct contact between new bone and the surface of the titanium in granular- or block-type IP-CHA was found in a rabbit bone defect. Further, new bone formation was found in direct contact with the implant surface in the block-type IP-CHA in an onlay graft model, and the implant stability quotient (ISQ) values were significantly increased after surgery. Therefore, IP-CHA may be a useful material for implant treatment in reconstructive surgery strategies.
authors.affiliation: Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Minami
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takechi
authors.forename: Kouji
authors.initials: K
authors.lastname: Ohta
authors.forename: Akira
authors.initials: A
authors.lastname: Ohta
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ninomiya
authors.forename: Megumi
authors.initials: M
authors.lastname: Takamoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Fukui
authors.forename: Misato
authors.initials: M
authors.lastname: Tada
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kamata
mesh_terms: D000818:Animals; D001846:Bone Development; D002516:Ceramics; D015921:Dental Implants; D006882:Hydroxyapatites; D016348:Osseointegration; D011817:Rabbits; D014025:Titanium
chemical_list: D015921:Dental Implants; D006882:Hydroxyapatites; D014025:Titanium