title: Reclassification of European patients' cardiovascular risk using the updated Systematic Coronary Risk Evaluation algorithm.
abstract: Data from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA; ClinicalTrials.gov; NCT00882336) was used to assess the proportions of patients aged 50-65 years free of diabetes and not receiving lipid-lowering therapy (LLT) considered to be at low (<1%), intermediate (1% to <5%) and high (≥5%) 10-year risk of cardiovascular mortality according to the Systematic Coronary Risk Evaluation (SCORE) algorithm and the updated algorithm that considers patients' total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels as independent variables (SCORE-HDL). Of 2321 patients analysed, 19.3%, 60.7% and 20.0% were considered to be at low, intermediate and high cardiovascular risk respectively according to SCORE, and 25.7%, 57.2% and 17.1% respectively according to SCORE-HDL. Thus, there was an overall trend towards reclassification from higher to lower risk categories when SCORE-HDL was compared with SCORE.
authors.affiliation: Wales Heart Research Institute, Cardiff University School of Medicine, UK halcoxjp@cardiff.ac.uk.
authors.forename: Julian P
authors.initials: JP
authors.lastname: Halcox
authors.affiliation: Assistance-Publique-Hôpitaux de Paris, France; Université Paris Diderot, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Tubach
authors.affiliation: AstraZeneca Global Medical Affairs, UK.
authors.forename: Ogün
authors.initials: O
authors.lastname: Sazova
authors.affiliation: Research Evaluation Unit, Oxford PharmaGenesis Ltd, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Sweet
authors.affiliation: Observational Research Centre, AstraZeneca, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Medina
mesh_terms: D000368:Aged; D000465:Algorithms; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000145:classification* / Q000401:mortality*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D002784:Cholesterol
keywords: Cardiology; estimation techniques; risk factors