title: Neuroblastoma and MYCN.
abstract: Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
authors.affiliation: Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, California 94158-9001.
authors.forename: Miller
authors.initials: M
authors.lastname: Huang
authors.forename: William A
authors.initials: WA
authors.lastname: Weiss
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology; D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D049109:Cell Proliferation; D005784:Gene Amplification / Q000235:genetics; D015870:Gene Expression; D016259:Genes, myc / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D000071447:N-Myc Proto-Oncogene Protein; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D055550:Protein Stability; D012307:Risk Factors; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D005819:Genetic Markers; C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins