title: Nucleophilic substitution of azide acting as a pseudo leaving group: one-step synthesis of various aza heterocycles.
abstract: The reaction of 3-azidopropanoic acid with the carbodiimide-based coupling reagent DIC leads to a six-membered-ring intermediate acting as a versatile precursor to a diverse set of aza heterocycles, including mono-, bi-, and tricyclic compounds.
authors.affiliation: Laboratoire d'Innovation Thérapeutique, UMR7200, CNRS, Université de Strasbourg, Faculté de pharmacie , 74, route du rhin, 67400 Illkirch, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Doebelin
authors.forename: Martine
authors.initials: M
authors.lastname: Schmitt
authors.forename: Cyril
authors.initials: C
authors.lastname: Antheaume
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bourguignon
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bihel
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001372:Aza Compounds; D001386:Azides; D006571:Heterocyclic Compounds