title: Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression.
abstract: A novel experience induces the Arc/Arg3.1 gene as well as plasticity of CA1 neural networks. To understand how these are linked, we briefly exposed GFP reporter mice of Arc transcription to a novel environment. Excitatory synaptic function of CA1 neurons with recent in vivo Arc induction (ArcGFP+) was similar to neighboring noninduced neurons. However, in response to group 1 metabotropic glutamate receptor (mGluR) activation, ArcGFP+ neurons preferentially displayed long-term synaptic depression (mGluR-LTD) and robust increases in dendritic Arc protein. mGluR-LTD in ArcGFP+ neurons required rapid protein synthesis and Arc, suggesting that dendritic translation of Arc underlies the priming of mGluR-LTD. In support of this idea, novelty exposure increased Arc messenger RNA in CA1 dendrites and promoted mGluR-induced translation of Arc in hippocampal synaptoneurosomes. Repeated experience suppressed synaptic transmission onto ArcGFP+ neurons and occluded mGluR-LTD ex vivo. mGluR-LTD priming in neurons with similar Arc activation history may contribute to encoding a novel environment.
authors.affiliation: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Vikram
authors.initials: V
authors.lastname: Jakkamsetti
authors.forename: Nien-Pei
authors.initials: NP
authors.lastname: Tsai
authors.forename: Christina
authors.initials: C
authors.lastname: Gross
authors.forename: Gemma
authors.initials: G
authors.lastname: Molinaro
authors.forename: Katie A
authors.initials: KA
authors.lastname: Collins
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Kuan H
authors.initials: KH
authors.lastname: Wang
authors.forename: Pavel
authors.initials: P
authors.lastname: Osten
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Bassell
authors.forename: Jay R
authors.initials: JR
authors.lastname: Gibson
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Huber
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism; D017930:Genes, Reporter / Q000235:genetics; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000528:radiation effects; D009474:Neurons / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D015533:Transcriptional Activation / Q000235:genetics / Q000502:physiology
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D018094:Receptors, Metabotropic Glutamate; C092069:activity regulated cytoskeletal-associated protein; C104077:metabotropic glutamate receptor type 1