title: Hidden Markov chain modeling for epileptic networks identification.
abstract: The partial epileptic seizures are often considered to be caused by a wrong balance between inhibitory and excitatory interneuron connections within a focal brain area. These abnormal balances are likely to result in loss of functional connectivities between remote brain structures, while functional connectivities within the incriminated zone are enhanced. The identification of the epileptic networks underlying these hypersynchronies are expected to contribute to a better understanding of the brain mechanisms responsible for the development of the seizures. In this objective, threshold strategies are commonly applied, based on synchrony measurements computed from recordings of the electrophysiologic brain activity. However, such methods are reported to be prone to errors and false alarms. In this paper, we propose a hidden Markov chain modeling of the synchrony states with the aim to develop a reliable machine learning methods for epileptic network inference. The method is applied on a real Stereo-EEG recording, demonstrating consistent results with the clinical evaluations and with the current knowledge on temporal lobe epilepsy.
authors.forename: Steven
authors.initials: S
authors.lastname: Le Cam
authors.forename: Valérie
authors.initials: V
authors.lastname: Louis-Dorr
authors.forename: Louis
authors.initials: L
authors.lastname: Maillard
mesh_terms: D000465:Algorithms; D001921:Brain / Q000503:physiopathology; D003936:Diagnosis, Computer-Assisted; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008390:Markov Chains; D012640:Seizures / Q000175:diagnosis* / Q000503:physiopathology; D058067:Wavelet Analysis