title: [Piascledin in the treatment of chronic dorsalgia].
abstract: Piascledine is a plant drug which positively influences the metabolism of cartilage and bone tissues. The authors studied the therapeutic effect of the drug in outpatients with chronic nonspecific dorsalgia. Piascledine was administered in dose 300 mg daily during two months. In the first month, it was used in the combination with artrosilene (320 mg daily). A comparison group included patients receiving monotherapy with NSAIDs (artrosilene). The study confirmed the high analgesic efficacy of piascledine in the treatment of patients with chronic nonspecific dorsalgia with controlled using of NSAIDs. The positive effect of piascledine was demonstrated after one month of treatment. The authors suggest that further clinical trials and placebo-control studies are needed to confirm these results.
authors.affiliation: Nevrologicheskiĭ tsentr im. B.M. Gekhta NUZ TsKB #2 im. N.A. Semashko OAO "RZhD"; FGBU "Nauchno-issledovatel'skiĭ institut obshcheĭ patologii i patofiziologii" RAMN, Moskva.
authors.forename: D M
authors.initials: DM
authors.lastname: Merkulova
authors.forename: A A
authors.initials: AA
authors.lastname: Onsin
authors.forename: Yu A
authors.initials: YA
authors.lastname: Merkulov
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D001416:Back Pain / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000008:administration & dosage / Q000627:therapeutic use*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D010840:Phytosterols; D010936:Plant Extracts; C003884:piascledine; D014810:Vitamin E; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine