title: Realistic biomechanical model of a cancerous breast for the registration of prone to supine deformations.
abstract: We develop a large deformations, Finite Elements biomechanical model of a stellate breast tumour, subject to prone to supine (MRI to US) breast deformations. Based on clinical findings, we introduce a volume of increased mammographic density/stiffness around a spiculated tumour, as well as a range of reported mechanical properties, both linear elastic and hyperelastic. This novel model demonstrates that these have a non-negligible effect on stresses and displacements, which, in turn, have implications, for example, in breast registration. We also show that the choice of material properties plays a dramatic effect on the mechanical variables.
authors.forename: Carolina
authors.initials: C
authors.lastname: Wessel
authors.forename: Julia A
authors.initials: JA
authors.lastname: Schnabel
authors.forename: Michael
authors.initials: M
authors.lastname: Brady
mesh_terms: D001696:Biomechanical Phenomena; D001940:Breast / Q000473:pathology; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D042361:Mammary Glands, Human / Q000002:abnormalities; D008327:Mammography / Q000379:methods*; D008962:Models, Theoretical; D016684:Prone Position; D016683:Supine Position; D016217:Ultrasonography, Mammary