title: Dabigatran-related intracerebral hemorrhage resulting in hematoma expansion.
abstract: Warfarin-related intracerebral hemorrhage carries a particularly high risk of neurologic deterioration and death because of a high rate of hematoma expansion of about 50%. Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. We present a case that suggests that hematoma expansion may occur after NOAC-related ICH.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: clasim@rm.dk.
authors.forename: Claus Z
authors.initials: CZ
authors.lastname: Simonsen
authors.affiliation: Department of Neurology, Frankfurt am Main, Germany; Department of Neurology, Heidelberg University Hospital, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Steiner
authors.affiliation: Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Anna
authors.initials: A
authors.lastname: Tietze
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Damgaard
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D000069604:Dabigatran; D017809:Fatal Outcome; D006406:Hematoma / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran
keywords: Intracerebral hemorrhage; anticoagulant; atrial fibrillation; stroke