title: New phenolics from the flowers of Punica granatum and their in vitro α-glucosidase inhibitory activities.
abstract: Two new phenolics, a 3-substituted coumarin, 7,8-dihydroxy-3-carboxymethylcoumarin-5-carboxylic acid, and a hydrolyzable tannin, namely punicatannin C, together with 10 known phenolics, were isolated from the flowers of pomegranate (Punica granatum). Their structures were determined on the basis of extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR data. All the isolates were evaluated for in vitro α-glucosidase inhibitory activities.
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States.
authors.forename: Tao
authors.initials: T
authors.lastname: Yuan
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Wan
authors.forename: Hang
authors.initials: H
authors.lastname: Ma
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry*; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029561:Lythraceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D000520:alpha-Glucosidases / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000589402:7,8-dihydroxy-3-carboxymethylcoumarin-5-carboxylic acid; D003374:Coumarins; D004791:Enzyme Inhibitors; D047348:Hydrolyzable Tannins; D010636:Phenols; D010936:Plant Extracts; C000589404:punicatannin C; D000520:alpha-Glucosidases