title: Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia.
abstract: Staphylococcus aureus is frequently found in patients with atopic dermatitis (AD) and contributes to disease exacerbation. The objective of this study was to evaluate the efficacy and safety of bleach baths as an adjunctive treatment in AD patients. Patients between 2 and 30 years old with moderate to severe AD were enrolled in a prospective, randomized, placebo-controlled study. Patients soaked in diluted bleach or distilled water baths for 10 min, twice a week for 2 months. Efficacy assessments included the Eczema Area and Severity Index (EASI) scores and S. aureus density was determined using quantitative bacterial cultures. Patients in the treatment group showed significant reductions in EASI scores. A 41.9% reduction in S. aureus density from baseline was seen at 1 month further reducing to 53.3% at 2 months. Equal numbers of patients in both groups experienced mild side-effects. This study demonstrates that diluted bleach baths clinically improved AD in as little as 1 month. No patient withdrew from the treatment arm because of intolerance to the baths.
authors.affiliation: Dermatology Unit, Department of Medicine, Medical Faculty, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Su-ming
authors.initials: SM
authors.lastname: Wong
authors.forename: Ting Guan
authors.initials: TG
authors.lastname: Ng
authors.forename: Roshidah
authors.initials: R
authors.lastname: Baba
mesh_terms: D000293:Adolescent; D001494:Baths / Q000009:adverse effects / Q000706:statistics & numerical data*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D004202:Disinfectants / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D011446:Prospective Studies; D012973:Sodium Hypochlorite / Q000627:therapeutic use*; D013207:Staphylococcal Skin Infections / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004202:Disinfectants; D012973:Sodium Hypochlorite
keywords: Staphylococcus aureus; atopic dermatitis; bleach baths; sodium hypochlorite