title: Inhibitory effect of four triterpenoids from trichilia connaroides on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells.
abstract: Two new highly rearranged trichiliton-type limonoids (trichilitons G-H, 1-2), and two new cycloartane-type triterpenoids, 21-(E)-coumaroyloxy-5α-cycloart-24-ene-3,23-dione (3) and 21-(E)-feruloyloxy-5α-cycloart-24-ene-3,23-dione (4), were isolated from the stem and bark of Trichilia connaroides. These isolates were elucidated on the basis of detailed spectroscopic analysis, and inhibitory effect of these compounds on lipopolysaccharide-induced nitric oxide production in mouse macrophage RAW264.7 cells was evaluated.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000818:Animals; D002460:Cell Line; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D008070:Lipopolysaccharides; D014315:Triterpenes; D009569:Nitric Oxide