title: Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs.
abstract: Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional polyester-based hydrogels. In vivo biocompatibility studies revealed that the in situ formed gels in the subcutaneous layer last for ≈ 21 days, and H&E staining study suggested acceptable biocompatibility of our materials in vivo. Then the hydrogels were tried as injectable implants to encapsulate antitumor drug, paclitaxel (PTX), to assess the in situ anti-tumoral activity using liver cancer xenograft model. The results demonstrated that the PTX-incorporated hydrogels could efficiently suppress the tumor growth, and did not result in obvious damage to normal organs. Therefore, the polypeptide-based thermosensitive hydrogels designed in the present study have great potential to serve as an effective platform for localized anti-cancer drug delivery.
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Cheng
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Xiao
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhuang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D020100:Hydrogels / Q000737:chemistry*; D020287:In Situ Nick-End Labeling; D008819:Mice, Nude; D010455:Peptides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels; D010455:Peptides
keywords: Anticancer; Local chemotherapy; Paclitaxel; Polypeptide; Thermosensitive hydrogels