title: [Association of polymorphisms of potassium voltage-gated channel, KQT-like subfamily, member 1 and type 2 diabetes in Jiangsu province, China].
abstract: OBJECTIVE
  To study the association of polymorphisms in the potassium voltage-gated channel, KQT-like subfamily,member 1(KCNQ1) gene with type 2 diabetes in Chinese population from Jiangsu province.
  
  
  METHODS
  Subjects consisting of 2925 cases and 3281 controls were enrolled from a community based cohort study of type 2 diabetes in Wuxi in 2007 and a community based cross-sectional survey on chronic non-communicable disease in Nantong in 2009. Epidemiological questionnaire survey and physical examinations were conducted and 10 h overnight fasting blood samples of 5 ml were drawn for all subjects.Genotypes were determined by TaqMan OpenArray Genotyping System and i-PLEX Sequenom MassARRAY platform. The relationship between KCNQ1 gene polymorphism and risk of type 2 diabetes after adjustment for age,sex and body mass index (BMI) was analyzed.
  
  
  RESULTS
  The C allele of rs2237897, rs2237892 and rs2237895 at KCNQ1 increased the risk of type 2 diabetes with adjusted OR (95%CI) value being 1.41(1.30-1.54), 1.35(1.24-1.47), 1.22(1.12-1.33) respectively (all P value < 0.05) under the additive genetic model after adjusted by age,sex and BMI. Stratification analyses in additive genetic model showed that the C allele of rs2237897 increased the risk of type 2 diabetes in subgroups stratified by age ( ≤ 56 years and > 56 years), sex (females and males), BMI (< 24 kg/m(2) and ≥ 24 kg/m(2)) with OR (95%CI) value being 1.39(1.22-1.59), 1.43(1.28-1.60), 1.40(1.26-1.55), 1.44(1.26-1.66), 1.48(1.33-1.66), 1.34(1.17-1.53) respectively (all P value< 0.05).
  
  
  CONCLUSIONS
  Polymorphisms of rs2237897, rs2237892 and rs2237895 in the KCNQ1 gene were associated with occurrence of type 2 diabetes among Jiangsu province population.
authors.affiliation: Department of Health Promotion, Wuxi Center for Disease Control and Prevention,Wuxi 214023, China.
authors.forename: Yu-di
authors.initials: YD
authors.lastname: Lin
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Mei-hua
authors.initials: MH
authors.lastname: Dong
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
authors.forename: Guang-fu
authors.initials: GF
authors.lastname: Jin
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Hu
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Shen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051657:KCNQ1 Potassium Channel; C496909:KCNQ1 protein, human