title: Synthesis, molecular structure, DNA interaction and antioxidant activity of novel naphthoxazole compound.
abstract: A novel naphthoxazole compound 1 was synthesized and characterized. The crystal structure of the compound shows that N atom locates at β-position and oxygen atom at α-position in naphthalene cycle. The DNA binding was studied by absorption spectroscopy, viscosity and luminescence spectra. The DNA binding constant was determined to be 6.16×10(3). The stoichiometry of compound/DNA is 1:1. The pBR322 DNA cleavage induced by the compound was investigated. The antioxidant activity of the compound against hydroxyl radical was also explored.
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
authors.forename: Xiu-Zhen
authors.initials: XZ
authors.lastname: Wang
authors.forename: Guan-Bin
authors.initials: GB
authors.lastname: Jiang
authors.forename: Yang-Yin
authors.initials: YY
authors.lastname: Xie
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects*; D017665:Hydroxyl Radical / Q000737:chemistry; D008958:Models, Molecular; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010080:Oxazoles; D017665:Hydroxyl Radical; D004247:DNA
keywords: Antioxidation; DNA cleavage; DNA-binding; Naphthoxazole compound