title: Near-infrared spectroscopy system for determining brain hemoglobin level.
abstract: Traumatic brain injury (TBI) usually results from brain shaking or impact. It can affect the normal function of the brain and even cause people become disabled and death. However, there is lack of studies for the physiological changes of humans or animals under brain injury. In order to obtain the information of physiological state change, we designed and enforced a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) for monitoring the concentration change of oxy-hemoglobin (HbO2), deoxy-hemoglobin (HbR) and total-hemoglobin (HbT) continuously during and after TBI. The experimental results indicated that the concentration change of HbO2 and HbT is significantly related to the impact strength and infarction volume. Thus, this system is easily used and stable for TBI study.
authors.forename: Pei-Jung
authors.initials: PJ
authors.lastname: Wu
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Chang
authors.forename: Cheng-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Wang
authors.forename: Jinn-Rung
authors.initials: JR
authors.lastname: Kuo
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Huang
authors.forename: Bor-Shyh
authors.initials: BS
authors.lastname: Lin
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D001930:Brain Injuries / Q000097:blood*; D006801:Humans; D008297:Male; D064926:Neurophysiological Monitoring; D010108:Oxyhemoglobins / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared
chemical_list: D010108:Oxyhemoglobins