title: Is 1H NMR metabolomics becoming the promising early biomarker for neonatal sepsis and for monitoring the antibiotic toxicity?
abstract: Metabolomics, the latest of omics disciplines, has been successfully used in various fields of basic research such as pharmacology and toxicology. Recently, this new science has gained an important role in the translational research of diagnostics. In this regard, the challenge for neonatologists and medical laboratories is to diagnose neonatal sepsis, a disease with high mortality and morbidity due to the difficulty in diagnosing it. Metabolomics, through its ability to identify perturbations caused by this condition, aims at recognizing metabolites that characterize neonatal sepsis with high specificity and sensitivity. The purpose of this review is to highlight the ability of metabolomics to find early biomarkers for this condition, as well as to predict the toxic effects caused by antibiotics.
authors.forename: Antonio
authors.initials: A
authors.lastname: Noto
authors.forename: Michele
authors.initials: M
authors.lastname: Mussap
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000378:metabolism*; D055432:Metabolomics / Q000379:methods* / Q000639:trends; D066244:Proton Magnetic Resonance Spectroscopy; D018805:Sepsis / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers
keywords: 1H NMR,; Aminoglycosides; Antibiotics,; Metabolomics,; Neonatal sepsis,; Renal toxicity,