title: Protein tyrosine phosphatase PTP1B in cell adhesion and migration.
abstract: Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence, including their coupling, dynamics, and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.
authors.affiliation: Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH); Universidad Nacional de San Martín; Consejo Nacional de Investigaciones Científicas y Técnicas; Buenos Aires, Argentina.
authors.forename: Carlos O
authors.initials: CO
authors.lastname: Arregui
authors.affiliation: Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH); Universidad Nacional de San Martín; Consejo Nacional de Investigaciones Científicas y Técnicas; Buenos Aires, Argentina.
authors.forename: Ángela
authors.initials: Á
authors.lastname: González
authors.affiliation: Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH); Universidad Nacional de San Martín; Consejo Nacional de Investigaciones Científicas y Técnicas; Buenos Aires, Argentina.
authors.forename: Juan E
authors.initials: JE
authors.lastname: Burdisso
authors.affiliation: Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús (IIB-INTECH); Universidad Nacional de San Martín; Consejo Nacional de Investigaciones Científicas y Técnicas; Buenos Aires, Argentina.
authors.forename: Ana E
authors.initials: AE
authors.lastname: González Wusener
mesh_terms: D002448:Cell Adhesion / Q000235:genetics*; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000235:genetics*; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000235:genetics* / Q000378:metabolism; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D010766:Phosphorylation; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000235:genetics; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D016023:Integrins; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human; D019061:src-Family Kinases; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D020741:rho GTP-Binding Proteins
keywords: PTP1B; Src; adhesions; cytoskeleton; endoplasmic reticulum; integrins; migration; α-actinin