title: [Primary and secondary resistance to nicotine replacement therapy in tobacco dependent patients].
abstract: The terms of primary and secondary resistance to nicotine replacement therapy in tobacco dependent patients are defined. It is shown that treatment resistance is a result of a constellation of special clinical features of tobacco dependence, tolerance to nicotine, personality traits of the patients, family history of smoking, comorbid affective disorders and somatic diseases.
authors.affiliation: FGBU "Gosudarstvennyĭ nauchnyĭ tsentr sotsial'noĭ i sudebnoĭ psikhiatrii im. V.P. Serbskogo" Minzdrava RF, Moskva.
authors.forename: O I
authors.initials: OI
authors.lastname: Speranskaya
authors.forename: V K
authors.initials: VK
authors.lastname: Smirnov
authors.forename: K A
authors.initials: KA
authors.lastname: Bogdanov
mesh_terms: D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality; D012907:Smoking / Q000453:epidemiology; D016540:Smoking Cessation / Q000523:psychology; D014029:Tobacco Use Disorder / Q000188:drug therapy* / Q000453:epidemiology