title: Epidermal pigmentation in the human lineage is an adaptation to ultraviolet radiation.
authors.affiliation: Department of Anthropology, The Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802, USA; Stellenbosch Institute of Advanced Study, Stellenbosch, South Africa. Electronic address: ngj2@psu.edu.
authors.forename: Nina G
authors.initials: NG
authors.lastname: Jablonski
authors.forename: George
authors.initials: G
authors.lastname: Chaplin
mesh_terms: D000220:Adaptation, Biological / Q000528:radiation effects*; D006801:Humans; D008543:Melanins; D012880:Skin Pigmentation / Q000502:physiology*; D014466:Ultraviolet Rays
chemical_list: D008543:Melanins; C041877:eumelanin
keywords: 25(OH)D; 25-hydroxycholecalciferol, or 25-hydroxyvitamin D, or serum vitamin D; 5-MTFH; 5-methyltetrahydrofolate; 7-DHC; 7-dehydrocholesterol; ASIP; Barrier function; DHFR; Eumelanin; Folate; MC1R; MITF; Melanin; NTDs; ROS; SC; SLC24A5; TEWL; UVA; UVB; UVR; Vitamin D; agouti signaling protein; dihydrofolate reductase; melanocortin 1 receptor locus; microphthalmia-associated transcription factor; neural tube defects; reactive oxygen species; solute carrier family 24 (sodium/potassium/calcium exchanger), member 5, SLC24A5; stratum corneum; transepidermal water loss; ultraviolet A radiation; ultraviolet B radiation; ultraviolet radiation