title: Ultrasound analysis of the uterine wall movement for improved electrohysterographic measurement and modeling.
abstract: During pregnancy, analysis of the electrohysterogram (EHG), which measures the uterine electrical activity, can provide a fundamental contribution for the assessment of uterine contractions and the diagnosis of preterm labor. However, several aspects concerning uterine physiology and its link with EHG measurements are still unclear. As a consequence, the EHG is not yet part of the clinical practice. There is general consensus that modeling and analysis of the EHG can be improved only by understanding and integrating the main properties of the uterine physiology at different levels, e:g:, cellular, tissue, and organ, and of different nature, e:g:, electrical, mechanical, and structural. In this study, we use transabdominal ultrasound (US) measurements to investigate the mechanical changes that the uterus undergoes during pregnancy under the effect of contractions. We refer to this measurement as mechanohysterogram. Analysis of the mechanohysterogram highlights, for the first time, two phenomena that can influence EHG signal interpretation, namely, changes in uterine wall thickness during contractions and respiration-induced uterine wall movements. Our results suggest that these phenomena can affect the interpretation of the EHG and should therefore be taken into account for accurate modeling and assessment of the uterine electrical activity.
authors.forename: Chiara
authors.initials: C
authors.lastname: Rabotti
authors.forename: Hinke
authors.initials: H
authors.lastname: de Lau
authors.forename: Nicole
authors.initials: N
authors.lastname: Haazen
authors.forename: Guid
authors.initials: G
authors.lastname: Oei
authors.forename: Massimo
authors.initials: M
authors.lastname: Mischi
mesh_terms: D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000502:physiology; D008962:Models, Theoretical; D009068:Movement; D011247:Pregnancy; D014465:Ultrasonics; D014463:Ultrasonography; D014590:Uterine Contraction / Q000502:physiology; D018590:Uterine Monitoring; D014599:Uterus / Q000000981:diagnostic imaging* / Q000502:physiology*