title: Merging the best of both worlds: hybrid lipid-enveloped matrix nanocomposites in drug delivery.
abstract: The advent of nanotechnology has revolutionized drug delivery in terms of improving drug efficacy and safety. Both polymer-based and lipid-based drug-loaded nanocarriers have demonstrated clinical benefit to date. However, to address the multifaceted drug delivery challenges ahead and further expand the spectrum of therapeutic applications, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymeric drug delivery systems and liposomes in a single nanocarrier. This review focuses on different classes of nanohybrids characterized by a drug-loaded polymeric matrix core enclosed in a lipid shell. Various nanoengineering approaches to obtain lipid-polymer nanocomposites with a core-shell nanoarchitecture will be discussed as well as their predominant applications in drug delivery.
authors.affiliation: Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. stefaan.desmedt@ugent.be.
authors.forename: Koen
authors.initials: K
authors.lastname: Raemdonck
authors.forename: Kevin
authors.initials: K
authors.lastname: Braeckmans
authors.forename: Jo
authors.initials: J
authors.lastname: Demeester
authors.forename: Stefaan C
authors.initials: SC
authors.lastname: De Smedt
mesh_terms: D000818:Animals; D032701:Biomimetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008055:Lipids / Q000737:chemistry; D053761:Nanocomposites / Q000008:administration & dosage* / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters / Q000737:chemistry; D012822:Silicon Dioxide
chemical_list: D008055:Lipids; D011091:Polyesters; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012822:Silicon Dioxide