title: Insulin and leptin levels in obese patients with and without breast cancer.
abstract: BACKGROUND
  Leptin has been associated with progression and poor survival in BC. Moreover, it is still controversial as to whether the effect of leptin depends only on its correlation with body mass index (BMI), or could be a direct role of adipokine in the development of BC. The aim of this study was to identify if there was a difference between serum leptin levels and insulin in obese patients with and without BC.
  
  
  METHODS
  A cross-sectional study was made in 156 women, a group of 78 with obesity and BC and 78 with obesity without BC. When subjects agreed to participate, written informed consent was obtained from all subjects. Biochemical variables such as glucose, triglycerides, high-density and low-density lipoprotein, cholesterol, insulin, and leptin were measured and homeostasis model assessment (HOMA-IR) was calculated.
  
  
  RESULTS
  The age, number of parities, glucose, HOMA-IR, and leptin were significantly different at P < .05.
  
  
  CONCLUSIONS
  Serum leptin levels and leptin/BMI ratio were statistically significantly increased in patients with BC.
authors.affiliation: Coordinación de Investigación en Salud, Delegación Estado de México Poniente, Instituto Mexicano del Seguro Social, Toluca, México. Electronic address: sromero61@hotmail.com.
authors.forename: Maria del Socorro
authors.initials: Mdel S
authors.lastname: Romero-Figueroa
authors.forename: José de Jesús
authors.initials: Jde J
authors.lastname: Garduño-García
authors.forename: Jesús
authors.initials: J
authors.lastname: Duarte-Mote
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Matute-González
authors.forename: Angel
authors.initials: A
authors.lastname: Gómez-Villanueva
authors.forename: Jhony
authors.initials: J
authors.lastname: De la Cruz-Vargas
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000209:etiology / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000473:pathology; D011379:Prognosis
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin
keywords: Breast cancer; Insulin; Insulin resistance; Leptina; Obesity