title: Systemic mastocytosis accompanied by a non-secretory plasma cell dyscrasia and nephrotic syndrome-level proteinuria in a 76-year-old patient.
abstract: We report here the interesting case of a 76-year-old man with severe proteinuria who was diagnosed with systemic mastocytosis accompanied by a clonal non-mast-cell lineage haematological disorder (a non-secretory plasma cell dyscrasia). This is a unique report of systemic mastocytosis with a non-secretory plasma cell dyscrasia and nephrotic syndrome. The pathophysiological relevance between these entities along with the probability of occult amyloidosis is discussed.
authors.affiliation: First Department of Internal Medicine, University of Athens, General Hospital 'Laiko', Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Papadopoulou
authors.forename: Savvas
authors.initials: S
authors.lastname: Ioannou
authors.forename: Georgia
authors.initials: G
authors.lastname: Levidou
authors.forename: Eleni
authors.initials: E
authors.lastname: Variami
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kouzis
authors.forename: Marina
authors.initials: M
authors.lastname: Siakantaris
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis; D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000473:pathology; D004396:Coloring Agents; D003224:Congo Red; D000068256:Darbepoetin alfa; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000627:therapeutic use; D005171:Factor X Deficiency / Q000150:complications; D005881:Gingiva / Q000473:pathology; D006474:Hemorrhagic Disorders / Q000209:etiology; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000188:drug therapy; D009404:Nephrotic Syndrome / Q000209:etiology*; D010265:Paraproteinemias / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000209:etiology*; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology; D050151:Subcutaneous Fat / Q000473:pathology
chemical_list: D004396:Coloring Agents; D006633:Histamine Antagonists; D004921:Erythropoietin; D000068256:Darbepoetin alfa; D003224:Congo Red; D011241:Prednisone