title: The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context.
abstract: This paper outlines the major components and function of the technologically integrated oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer (ACGT) project. The Oncosimulator is defined as an information technology system simulating in vivo tumor response to therapeutic modalities within the clinical trial context. Chemotherapy in the neoadjuvant setting, according to two real clinical trials concerning nephroblastoma and breast cancer, has been considered. The spatiotemporal simulation module embedded in the Oncosimulator is based on the multiscale, predominantly top-down, discrete entity-discrete event cancer simulation technique developed by the In Silico Oncology Group, National Technical University of Athens. The technology modules include multiscale data handling, image processing, invocation of code execution via a spreadsheet-inspired environment portal, execution of the code on the grid, and the visualization of the predictions. A refining scenario for the eventual coupling of the oncosimulator with immunological models is also presented. Parameter values have been adapted to multiscale clinical trial data in a consistent way, thus supporting the predictive potential of the oncosimulator. Indicative results demonstrating various aspects of the clinical adaptation and validation process are presented. Completion of these processes is expected to pave the way for the clinical translation of the system.
authors.forename: Georgios
authors.initials: G
authors.lastname: Stamatakos
authors.forename: Dimitra
authors.initials: D
authors.lastname: Dionysiou
authors.forename: Aran
authors.initials: A
authors.lastname: Lunzer
authors.forename: Robert
authors.initials: R
authors.lastname: Belleman
authors.forename: Eleni
authors.initials: E
authors.lastname: Kolokotroni
authors.forename: Eleni
authors.initials: E
authors.lastname: Georgiadi
authors.forename: Marius
authors.initials: M
authors.lastname: Erdt
authors.forename: Juliusz
authors.initials: J
authors.lastname: Pukacki
authors.forename: Stefan
authors.initials: S
authors.lastname: Rüeping
authors.forename: Stavroula
authors.initials: S
authors.lastname: Giatili
authors.forename: Alberto
authors.initials: A
authors.lastname: d'Onofrio
authors.forename: Stelios
authors.initials: S
authors.lastname: Sfakianakis
authors.forename: Kostas
authors.initials: K
authors.lastname: Marias
authors.forename: Christine
authors.initials: C
authors.lastname: Desmedt
authors.forename: Manolis
authors.initials: M
authors.lastname: Tsiknakis
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016923:Cell Death; D003198:Computer Simulation; D023281:Genomics / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D014411:Neoplastic Stem Cells; D014584:User-Computer Interface
chemical_list: D000970:Antineoplastic Agents