title: Physical stability of cholesterol derivatives combined with liposomes and their in vitro behavior.
abstract: The purpose of this study was to investigate the physical stability and drug release of two cholesterol derivatives (4-cholesterocarbonyl-4'-(N,N,N-triethylamine butyloxyl bromide, CTBBA, and 4-cholesterocarbonyl-4'-(N,N'-diethylamino-butyloxy, CDBA), when combined with doxorubicin (DOX)-loaded liposomes in vitro. CTBBA-liposome revealed a positive charge at a pH between 3 and 10, as indicated by the ζ-potential. DOX-encapsulated CTBBA-liposomes possessed better physical stability both in PBS and in fetal bovine serum (FBS) added to PBS.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Sheng-Yong
authors.initials: SY
authors.lastname: Geng
authors.forename: Jin-Ye
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000818:Animals; D002417:Cattle; D002784:Cholesterol / Q000737:chemistry*; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000494:pharmacology; D044967:Serum / Q000378:metabolism; D055672:Static Electricity
chemical_list: D008081:Liposomes; C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin; D002784:Cholesterol