title: Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report.
abstract: BACKGROUND
  The etiology of primary cutaneous anaplastic large-cell CD30+ lymphoma is largely unknown, and although an infectious involvement has been suspected, the implication of infectious agents in its pathogenesis is still unclear.
  
  
  RESULTS
  We report the case of a HIV-negative patient referred to our hospital with a rapidly enlarging skin tumor on her upper eyelid. Surgical excision was performed and histological analysis evidenced a primary cutaneous anaplastic large-cell lymphoma. Due to the ocular localization and to the prominent angiogenic component of the lesion, molecular analyses for the detection of Chlamydophila pneumoniae and HHV8 were performed, revealing the presence of an infection by both pathogens in surgical biopsy and in peripheral blood mononuclear cells.
  
  
  CONCLUSIONS
  These findings suggest for the first time a possible association of C. pneumoniae and/or HHV8 infection, or both together, with primary cutaneous anaplastic large-cell lymphoma in non-immunocompromised and HIV-negative subjects. This potential pathogenic association, if confirmed, could provide potential indications for future therapy.
authors.affiliation: Department of Medical Sciences, Section of Dermatology, University of Ferrara, Via Savonarola 9, 44121 Ferrara, Italy. vri@unife.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Borghi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Caselli
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
authors.forename: Adolfo
authors.initials: A
authors.lastname: Sebastiani
authors.forename: Paolo
authors.initials: P
authors.lastname: Perri
authors.forename: Silva
authors.initials: S
authors.lastname: Seraceni
authors.forename: Carlo
authors.initials: C
authors.lastname: Contini
authors.forename: Annarosa
authors.initials: A
authors.lastname: Virgili