title: Ocular manifestations of monoclonal copper-binding immunoglobulin.
abstract: The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.
authors.affiliation: Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
authors.forename: Sejal
authors.initials: S
authors.lastname: Shah
authors.affiliation: Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA; Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Espana
authors.affiliation: Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA; Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA. Electronic address: cmargo@health.usf.edu.
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Margo
mesh_terms: D057866:Anterior Capsule of the Lens / Q000378:metabolism*; D002387:Cataract Extraction; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D003316:Corneal Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D003886:Descemet Membrane / Q000378:metabolism*; D057111:Descemet Stripping Endothelial Keratoplasty; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007905:Lens Diseases / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000175:diagnosis*; D009101:Multiple Myeloma / Q000175:diagnosis; D013052:Spectrometry, X-Ray Emission
chemical_list: D003300:Copper; D002570:Ceruloplasmin
keywords: Descemet membrane; Kayser-Fleischer ring; M-protein; copper metabolism; copper-binding immunoglobulin; hypercupremia; monoclonal gammopathy; myeloma complication; trace metal