title: Initial combination of injectable and oral anti-tuberculosis agents for the treatment of severe disseminated tuberculosis.
abstract: There is a need for intravenous therapy for severe forms of tuberculosis in those who are HIV-positive, diabetic, have cystic fibrosis, extensive gastrointestinal involvement, haemodynamic instability with difficulty to take and absorb oral medications, which results in a lack of appropriate therapeutic effect during treatment, such as not creating the optimal blood concentration of the substance. We report an HIV-infected patient presenting with severe disseminated tuberculosis with extensive intestinal involvement which was successfully treated with an initial combination regimen of injectable and oral anti-tuberculosis agents. We discuss and emphasize the importance of an initial regimen with injectable and oral agents for treating severe forms of tuberculosis.
authors.affiliation: MD, Infectious Disease Section, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90640-000, Brazil. Lgoldani@ufrgs.br.
authors.forename: Diego F
authors.initials: DF
authors.lastname: Boff
authors.forename: Luciano Z
authors.initials: LZ
authors.lastname: Goldani
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: Injectable anti-TB agents; intestinal involvement; tuberculosis