title: MicroRNAs dysregulation in epilepsy.
abstract: Epilepsy is a syndrome characterized by recurrent spontaneous seizures due to neuronal hyperactivity in the brain. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have key roles in the pathogenesis of neurological disorders. Evidence indicates that miRNAs are emerging as a critical new layer of gene expression regulation with implications for the cause and treatment of epilepsy. Accumulating studies in epilepsy suggest that numerous specific miRNAs are dysregulated. Recent studies have explored several target genes and pathways of miRNAs in order to find out therapeutic approaches to epilepsy. Here, we review current findings regarding miRNA research in humans and animal models to provide a solid foundation for further research aiming at understanding the potential contribution of miRNAs to epilepsy pathophysiology.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Li
authors.affiliation: Department of Outpatient, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Neurology, the Affiliated Hospital of the Medical College of Qingdao University, China.
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China. Electronic address: yu-jintai@163.com.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China; College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China. Electronic address: dr.tanlan@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; C547077:MIRN132 microRNA, human; C569273:MIRN134 microRNA, human; C542542:MIRN146 microRNA, human; C524940:MIRN21 microRNA, human; C522425:MIRN34 microRNA, human; D035683:MicroRNAs
keywords: Dysregulation; Epilepsy; MicroRNA; Pathophysiology; Treatment