title: Association of interleukin-6 -174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey.
abstract: OBJECTIVE
  Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in type 2 DN and control subjects.
  
  
  METHODS
  The patients selected from the Department of Endocrinology and Metabolism Diseases included 43 type 2 diabetes mellitus patients without DN and 43 type 2 diabetes mellitus patients with DN and 340 healthy normal controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, and insulin and Il-6 gene polymorphism genetic analysis.
  
  
  RESULTS
  IL-6 -174 G>C genotype distribution was different between the control group and the type 2 diabetes mellitus patients (p=0.004). The higher frequency of the polymorphic G allele was also similar for the group with type 2 diabetes mellitus as for the control group. The frequency of the polymorphic G allele was 83.9% in diabetic patients with nephropathy versus 70.9% in those without nephropathy (p=0.039).
  
  
  CONCLUSIONS
  We suggest that the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for DN in Turkish type 2 diabetes mellitus patients.
authors.affiliation: 1 Department of Endocrinology and Metabolism, Sifa University Medical School , Izmir, Turkey .
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdogan
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Candeger
authors.initials: C
authors.lastname: Yilmaz
mesh_terms: D000368:Aged; D001483:Base Sequence; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014421:Turkey / Q000453:epidemiology
chemical_list: D017931:DNA Primers; D015850:Interleukin-6