title: Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.
abstract: Herpes simplex virus (HSV) proteins specifically required for endocytic entry but not direct penetration have not been identified. HSVs deleted of gE, gG, gI, gJ, gM, UL45, or Us9 entered cells via either pH-dependent or pH-independent endocytosis and were inactivated by mildly acidic pH. Thus, the required HSV glycoproteins, gB, gD, and gH-gL, may be sufficient for entry regardless of entry route taken. This may be distinct from entry mechanisms employed by other human herpesviruses.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University.
authors.forename: Tri
authors.initials: T
authors.lastname: Komala Sari
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Pritchard
authors.forename: Cristina W
authors.initials: CW
authors.lastname: Cunha
authors.forename: George A
authors.initials: GA
authors.lastname: Wudiri
authors.forename: Elizabeth I
authors.initials: EI
authors.lastname: Laws
authors.forename: Hector C
authors.initials: HC
authors.lastname: Aguilar
authors.forename: Naomi S
authors.initials: NS
authors.lastname: Taus
authors.forename: Anthony V
authors.initials: AV
authors.lastname: Nicola
mesh_terms: D002460:Cell Line; D004705:Endocytosis; D006561:Herpes Simplex / Q000503:physiopathology / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D014759:Viral Envelope Proteins