title: In silico oncology: exploiting clinical studies to clinically adapt and validate multiscale oncosimulators.
abstract: This paper presents a brief outline of the notion and the system of oncosimulator in conjunction with a high level description of the basics of its core multiscale model simulating clinical tumor response to treatment. The exemplary case of lung cancer preoperatively treated with a combination of chemotherapeutic agents is considered. The core oncosimulator model is based on a primarily top-down, discrete entity - discrete event multiscale simulation approach. The critical process of clinical adaptation of the model by exploiting sets of multiscale data originating from clinical studies/trials is also outlined. Concrete clinical adaptation results are presented. The adaptation process also conveys important aspects of the planned clinical validation procedure since the same type of multiscale data - although not the same data itself- is to be used for clinical validation. By having exploited actual clinical data in conjunction with plausible literature-based values of certain model parameters, a realistic tumor dynamics behavior has been demonstrated. The latter supports the potential of the specific oncosimulator to serve as a personalized treatment optimizer following an eventually successful completion of the clinical adaptation and validation process.
authors.forename: Georgios S
authors.initials: GS
authors.lastname: Stamatakos
authors.forename: Eleni
authors.initials: E
authors.lastname: Kolokotroni
authors.forename: Dimitra
authors.initials: D
authors.lastname: Dionysiou
authors.forename: Christian
authors.initials: C
authors.lastname: Veith
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Astrid
authors.initials: A
authors.lastname: Franz
authors.forename: Kostas
authors.initials: K
authors.lastname: Marias
authors.forename: Joerg
authors.initials: J
authors.lastname: Sabczynski
authors.forename: Rainer
authors.initials: R
authors.lastname: Bohle
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D035843:Biomedical Research; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D048749:Cytokinesis / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D015203:Reproducibility of Results
chemical_list: D000970:Antineoplastic Agents