title: Rhodium(I)-catalyzed cycloisomerization of nitrogen-tethered indoles and alkylidenecyclopropanes: convenient access to polycyclic indole derivatives.
abstract: At the end of its tether: A new synthetic protocol for the preparation of polycyclic indole derivatives has been developed from a rhodium(I)-catalyzed cycloisomerization of a nitrogen-tethered indole and alkylidenecyclopropane, affording the corresponding tetrahydro-β-carboline derivatives in moderate to good yields. Further transformations give a direct and rapid route to tetracyclic compounds through transition-metal catalysis.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P.R. China), Fax: (+86) 21-64166128.
authors.forename: Di-Han
authors.initials: DH
authors.lastname: Zhang
authors.forename: Xiang-Ying
authors.initials: XY
authors.lastname: Tang
authors.forename: Yin
authors.initials: Y
authors.lastname: Wei
authors.forename: Min
authors.initials: M
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007536:Isomerism; D009584:Nitrogen / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D003521:Cyclopropanes; D007211:Indoles; C030374:indole; D012238:Rhodium; D009584:Nitrogen
keywords: alkylidenecyclopropanes; cycloisomerization; indoles; polycyclic indoles; rhodium; tetrahydrocarbolines