title: Therapeutic cell encapsulation techniques and applications in diabetes.
abstract: The encapsulation of therapeutic cells permits the implantation of allogeneic and xenogeneic cells for the regulation of certain physiological processes damaged by the death or senescence of host tissues. The encapsulation of pancreatic cells for the treatment of diabetes is emphasized; however, many of the techniques are applicable to a wide array of mammalian cell applications. The summary of both established and novel encapsulation techniques, clinical trials, and commercial product developments highlights the metered but steady pace of therapeutic cell encapsulation towards implementation.
authors.affiliation: Department of Chemical Engineering, Queen's University, Kingston, Ontario K7L 3N6, Canada; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, SW7 2AZ, UK.
authors.forename: J A M
authors.initials: JA
authors.lastname: Steele
authors.affiliation: Maisonneuve-Rosemont AQ3 Hospital Research Center, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Hallé
authors.affiliation: ONIRIS, route de la Géraudière, BP 82225, 44322 Nantes, Cedex 3, France.
authors.forename: D
authors.initials: D
authors.lastname: Poncelet
authors.affiliation: Department of Chemical Engineering, Queen's University, Kingston, Ontario K7L 3N6, Canada. Electronic address: neufeld@queensu.ca.
authors.forename: R J
authors.initials: RJ
authors.lastname: Neufeld
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D004655:Emulsions; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D010179:Pancreas / Q000033:anatomy & histology; D016035:Pancreas Transplantation; D055672:Static Electricity; D054457:Tissue Scaffolds
chemical_list: D000464:Alginates; D004655:Emulsions; D006603:Hexuronic Acids; D020723:Glucuronic Acid
keywords: Bioencapsulation; Immunoisolation; Islets; Microcapsules