title: Femoral cartilage segmentation in knee MRI scans using two stage voxel classification.
abstract: Using more than one classification stage and exploiting class population imbalance allows for incorporating powerful classifiers in tasks requiring large scale training data, even if these classifiers scale badly with the number of training samples. This led us to propose a two-stage classifier for segmenting tibial cartilage in knee MRI scans combining nearest neighbor classification and support vector machines (SVMs). Here we apply it to femoral cartilage segmentation. We describe the similarities and differences between segmenting these two knee cartilages. For further speeding up batch SVM training, we propose loosening the stopping condition in the quadratic program solver before considering moving on to other approximation techniques such as online SVMs. The two-stage approach reached a higher accuracy in comparison to the one-stage state-of-the-art method. It also achieved better inter-scan segmentation reproducibility when compared to a radiologist as well as the current state-of-the-art method.
authors.forename: Adhish
authors.initials: A
authors.lastname: Prasoon
authors.forename: Christian
authors.initials: C
authors.lastname: Igel
authors.forename: Marco
authors.initials: M
authors.lastname: Loog
authors.forename: Francois
authors.initials: F
authors.lastname: Lauze
authors.forename: Erik B
authors.initials: EB
authors.lastname: Dam
authors.forename: Mads
authors.initials: M
authors.lastname: Nielsen
mesh_terms: D000465:Algorithms; D002356:Cartilage / Q000473:pathology*; D016000:Cluster Analysis; D005269:Femur / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007719:Knee Joint; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011871:Radiology / Q000379:methods; D015203:Reproducibility of Results; D060388:Support Vector Machine