title: Multiobjective patient-specific estimation of a coronary circulation model for triple vessel disease.
abstract: Computational models can help understand the hemodynamics of the coronary circulation, which is of the upmost importance to help clinicians before, during and after a coronary artery bypass graft surgery. In this paper, we propose a multiobjective optimization method for parameter estimation of a computational model representing the coronary circulation on patients with a triple vessel disease. This estimation was not based on any assumption regarding the development of the collateral circulation, like in previous works. Indeed, the collateral development of a given patient is estimated through the model parameters. Parameter estimation was performed using clinical data from three patients, obtained before and during an off-pump coronary artery bypass graft surgery (CABG). Results showed a better performance when comparing the simulation with clinical data, since the total error estimation for three patients was reduced by 40 ± 22%. Moreover, the proposed method provides new insight regarding the heterogeneous configuration of the alternative collateral vessels.
authors.forename: David
authors.initials: D
authors.lastname: Ojeda
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: Agnès
authors.initials: A
authors.lastname: Drochon
authors.forename: Majid
authors.initials: M
authors.lastname: Harmouche
authors.forename: Hervé
authors.initials: H
authors.lastname: Corbineau
authors.forename: Jean-Phillipe
authors.initials: JP
authors.lastname: Verhoye
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Hernández
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000503:physiopathology* / Q000601:surgery*; D003326:Coronary Circulation / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D015203:Reproducibility of Results