title: Lipoprotein(a) is not related to markers of insulin resistance in pregnancy.
abstract: BACKGROUND
  Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked to increased risk of cardiovascular disease. However, its relationship with insulin resistance, type 2 diabetes and gestational diabetes is controversial and unproven. Here we aimed to clarify whether Lp(a) levels are associated with insulin sensitivity in pregnancy.
  
  
  METHODS
  Sixty-four women with gestational diabetes and 165 with normal glucose tolerance were enrolled in the study. Fasting Lp(a) serum levels were measured in all women at 24-28 weeks of gestation.
  
  
  RESULTS
  In pregnancy, there was no significant difference in serum Lp(a) concentrations between the two groups. Its level did not correlate with markers of insulin resistance (HOMA-IR), insulin sensitivity (HOMA-S%), pancreatic beta-cell function (HOMA-B%) and insulin sensitivity in dynamic conditions (OGIS). In addition, fasting glucose and insulin levels and those throughout an oral glucose tolerance test were independent of Lp(a) concentrations in our study group.
  
  
  CONCLUSIONS
  Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a).
authors.affiliation: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. alexandra.kautzky-willer@meduniwien.ac.at.
authors.forename: Jelena
authors.initials: J
authors.lastname: Todoric
authors.forename: Ammon
authors.initials: A
authors.lastname: Handisurya
authors.forename: Karoline
authors.initials: K
authors.lastname: Leitner
authors.forename: Juergen
authors.initials: J
authors.lastname: Harreiter
authors.forename: Gregor
authors.initials: G
authors.lastname: Hoermann
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kautzky-Willer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D017270:Lipoprotein(a) / Q000097:blood*; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D017270:Lipoprotein(a)