title: A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds.
abstract: The present review reports the antifungal activity of mushroom extracts and isolated compounds including high (e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore, the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well as safety issues.
authors.affiliation: CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal|Centro Hospitalar de Trás-os-Montes e Alto Douro- Unidade de Chaves, Av. Dr. Francisco Sá Carneiro, 5400-249 Chaves, Portugal|Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal|Escola Superior de Saúde, Instituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança, Portugal
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Alves
authors.affiliation: Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
authors.affiliation: Escola Superior de Saúde, Instituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança, Portugal
authors.forename: Joana
authors.initials: J
authors.lastname: Dias
authors.affiliation: Escola Superior de Saúde, Instituto Politécnico de Bragança, Av. D. Afonso V, 5300-121 Bragança, Portugal
authors.forename: Vânia
authors.initials: V
authors.lastname: Teixeira
authors.affiliation: Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal
authors.forename: Anabela
authors.initials: A
authors.lastname: Martins
authors.affiliation: CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
authors.forename: Manuela
authors.initials: M
authors.lastname: Pintado
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D013729:Terpenes; C058858:grifolin