title: Oocyte development and loss.
abstract: Soon after implantation, cell lineages bifurcate into future somatic and germ cells. Canonical expression of germ cell-specific genes continues during and after their migration to the gonadal ridge, where, after further cell cycles, they enter meiosis, form syncytial clusters, and arrest at diplotene for folliculogenesis. The balance between cell survival and death leaves an ovarian follicular reserve as a legacy.
authors.affiliation: Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, New York.
authors.forename: Roger G
authors.initials: RG
authors.lastname: Gosden
mesh_terms: D000375:Aging; D000818:Animals; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D009866:Oogenesis; D010053:Ovary / Q000196:embryology / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology*; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000503:physiopathology*; D012720:Severity of Illness Index