title: Docetaxel-induced Hand and Foot Syndrome in a Patient with Metastatic Breast Carcinoma.
abstract: Hand and foot syndrome (HFS) is a well-known complication of chemotherapeutic drugs given in a dose-dense manner. Our patient was a 52-year-old female with metastatic breast carcinoma on salvage chemotherapy regimen with docetaxel at a dose of 60 mg/m(2). The patient had grade 3 HFS characterized by symmetrical, tender, and erythematous skin lesions over the palms and soles associated with dysesthesia necessitating interruption of treatment. She developed this syndrome at a much lower dose than previously described due to her altered hepatic function. An insight regarding this unique distressing side-effect and assessment of various contributing factors would help us identify and treat the patient at the earliest.
authors.affiliation: Department of Dermatology, Apollo Speciality Cancer Hospital, Anna salai, Chennai, India.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Gurumurthi
authors.forename: Ramesh Bv
authors.initials: RB
authors.lastname: Nimmagadda
authors.forename: Subhashini
authors.initials: S
authors.lastname: Mohan
keywords: Hand and foot syndrome; docetaxel-induced acral erythema; palmar - plantar erythrodysesthesia