title: [Cardioprotective effect of remote postconditioning: mechanisms and possibility of clinical application].
abstract: Experimental data indicate that postconditioning at distance is an effective method of cardiac protection against reperfusion injury. Remote postconditioning prevents reperfusion necrosis and apoptosis of cardiomyocytes, decreases probability of postinfarction remodeling of the heart. Cardioprotective effect of remote postconditioning is depended on release from tissues after transient ischemia of humoral factor(s) increasing cardiac tolerance to long-term ischemia-reperfusion. Clinical studies show that postconditioning at distance is an effective method of prevention of reperfusion injury of the heart during coronary artery bypass surgery.
authors.affiliation: Research Institute for Cardiology of SB of the RAMS, ul. Kievskaya, 111a, 634012 Tomsk, Russia.
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: A G
authors.initials: AG
authors.lastname: Mrochek
authors.forename: A V
authors.initials: AV
authors.lastname: Gurin
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D005544:Forecasting; D006321:Heart / Q000503:physiopathology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods / Q000639:trends; D023421:Models, Animal; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D012107:Research Design; D036302:Therapeutic Human Experimentation; D014336:Troponin / Q000097:blood; D020257:Ventricular Remodeling
chemical_list: D014336:Troponin; D003402:Creatine Kinase