title: Synthesis of new andrographolide derivatives and evaluation of their antidyslipidemic, LDL-oxidation and antioxidant activity.
abstract: Andrographis paniculata, native to Taiwan, Mainland China and India, is a medicinal herb, which possesses various biological activities including anti-atherosclerosis. Andrographolide (1) has been identified as one of the active constituents against atherosclerosis. In continuation of our drug discovery program we synthesized few novel derivatives of 1 to improve their antidyslipidemic, LDL-oxidation and antioxidant activity. The tosylated derivative 7 has been turned out to be more potent than the parent compound and comparable activity with marketed antidyslipidemic drugs.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR - Central Drug Research Institute, Lucknow 226 001, U.P., India.
authors.forename: Sukanya
authors.initials: S
authors.lastname: Pandeti
authors.forename: Ravi
authors.initials: R
authors.lastname: Sonkar
authors.forename: Astha
authors.initials: A
authors.lastname: Shukla
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: Narender
authors.initials: N
authors.lastname: Tadigoppula
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D004195:Disease Models, Animal; D004224:Diterpenes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D015394:Molecular Structure; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000975:Antioxidants; D004224:Diterpenes; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; C030419:andrographolide
keywords: Andographis paniculata; Andrographolide derivatives; Anti oxidant activity; Antidyslipidemic activity; LDL oxidation; LPL activity