title: Changing trends in the treatment of dry-eye disease.
abstract: BACKGROUND
  Dry eye is a visually disabling disease encountered in many countries with a wide variation of treatment practices all over the world. On that front, the 2007 Report of the International Dry Eye WorkShop (DEWS) reviewed the current knowledge on all aspects of dry-eye disease (DED), in an evidence-based manner, and outlined the trends and recommendations in the treatment of DED on the basis of disease severity.
  
  
  METHODS
  This review mainly focuses on treatments for DED based on severity as recommended in the DEWS report, particularly artificial eye drops, hyaluronate sodium eye drops, autologous serum, anti-inflammatory eye drops including cyclosporine and steroids, and mucin secretagogues. New dry-eye treatment modalities in current trials outlined on the clinicaltrial.gov site are also outlined.
  
  
  CONCLUSIONS
  Further investigations into the mechanism of action of the new mucin and tear secretagogues which have been suggested to have anti-inflammatory properties will enrich our understanding in relation to relevant ocular surface responses after treatment with these new agents.
authors.affiliation: Tokyo Dental College Ichikawa Hospital, Department of Ophthalmology , Chiba , Japan.
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000818:Animals; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D006801:Humans; D009883:Ophthalmic Solutions / Q000627:therapeutic use
chemical_list: D009883:Ophthalmic Solutions