title: The function of human epidermal growth factor receptor-3 and its role in tumors (Review).
abstract: Human epidermal growth factor receptor-3 (HER-3) is the third member of the HER family. It was previously considered not to contain tyrosine kinase activity and catalytic activity and the intracellular region of HER-3 could not bind ATP and be auto-phosphorylated. Thus, the clinical value of HER-3 was ignored. Currently, biochemical analysis has confirmed that the kinase domain of HER-3 is a specific allosteric activator; it acts as a functional activator to activate the recipient kinase (HER-1, HER-2, HER-4). With the in-depth knowledge of its structure and function, studies on the relationship of HER-3 and human tumors are rapidly increasing. HER-3 is closely related to tumorigenesis, progression and metastasis. HER-3 is involved in resistance to targeted therapy, and may serve as a new therapeutic target. The expression of HER-3 helps to predict prognosis and treatment efficacy. HER-3 has become a focus of concern in the HER family and has gained significant attention in the search for cancer treatment.
authors.affiliation: Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Yuan
authors.forename: Bangwei
authors.initials: B
authors.lastname: Cao
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D063646:Carcinogenesis / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D010766:Phosphorylation; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D020893:Receptor, ErbB-3 / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; C508053:ERBB2 protein, human