title: Self-assembling nanofibers improve cognitive impairment in a transgenic mice model of Alzheimer's disease.
abstract: The peptide amphiphile (PA) with a laminin epitope IKVAV (IKVAV-PA) can be trigged into three-dimensional nanostructures in vivo. Application of IKVAV-PA to the injured spinal cord resulted in significant functional improvement in rodents with remarkable axonal regeneration at the lesion site. Here we showed that injection of IKVAV-PA into the hippocampus of a transgenic (Tg) mice model of Alzheimer's disease (AD) significantly improved cognitive impairment, accompanied by an enhanced neurogenesis in the hippocampus. Further examination demonstrated that IKVAV-PA injections also significantly reduced the levels of soluble Aβ1-40, Aβ1-42, and amyloid-beta (Aβ) plaques in these brains. Our data suggest that IKVAV-PA may serve as a potential therapeutic intervention for the learning and memory losses in AD.
authors.affiliation: Department of Neural Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, China.
authors.forename: Hongna
authors.initials: H
authors.lastname: Yang
authors.forename: Tingyu
authors.initials: T
authors.lastname: Qu
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Lifei
authors.initials: L
authors.lastname: Wei
authors.forename: Zhaohong
authors.initials: Z
authors.lastname: Xie
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Bi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007797:Laminin / Q000627:therapeutic use*; D020935:MAP Kinase Signaling System; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D057139:Nanofibers / Q000627:therapeutic use*; D058953:Neural Stem Cells / Q000187:drug effects / Q000473:pathology; D055495:Neurogenesis; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism / Q000627:therapeutic use*; D058225:Plaque, Amyloid / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D007797:Laminin; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); C083321:isoleucyl-lysyl-valyl-alanyl-valine; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3
keywords: Alzheimer's disease; Amyloid-beta; Cognition; Neurogenesis; Peptide amphiphile