title: Association between melanocortin-4 receptor mutations and eating behaviors in obese patients: a case--control study.
abstract: Melanocortin-4 receptor (MC4R) gene mutations are involved in the leptin-melanocortin pathways that control food intake. The effect of these mutations on eating behavior phenotypes is still debated. To determine the association between functional MC4R mutations and eating behaviors, dietary intake and physical activity, we sequenced the MC4R gene in 4653 obese adults. Among them, 19 adults carriers of functional MC4R mutation were matched on age, sex and body mass index with two randomly-paired controls without MC4R mutation (n=57). We found that eating behaviors and physical activity did not differ between groups. In particular, cases were not at increased risk of binge eating disorders. Subjects carriers of MC4R mutation reported a higher proportion of dietary carbohydrates intakes (43.2±7.1 and 39.2±8.1% of total energy intake, respectively, P=0.048) and a lower proportion of dietary lipids (34.3±6.7 and 38.5±6.7% of total energy intake, respectively, P=0.018). In conclusion, mutation carriers differ from controls by a higher consumption of carbohydrates counterbalanced by a lower consumption of lipids expressed as percentage of total energy intake. However, functional MC4R mutations do not have a higher risk of compulsive eating contrary to what was previously suggested.
authors.affiliation: Sorbonne Paris Cité, Nutritional Epidemiology Research Unit-UMR U557 INSERM, U1125 INRA, CNAM, Paris 13 University, CRNH-IdF, Bobigny, France.
authors.forename: M
authors.initials: M
authors.lastname: Valette
authors.affiliation: 1] Institute of cardiometabolism and nutrition (ICAN), Pitié Salpêtriére hospital, Paris, France [2] Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, Heart and Metabolism Division, Paris, France [3] CRNH-Ile de France, Paris, France [4] INSERM U872, Team Nutriomique, Paris, France [5] Pierre and Marie Curie University - Paris 6, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Poitou
authors.affiliation: Sorbonne Paris Cité, Nutritional Epidemiology Research Unit-UMR U557 INSERM, U1125 INRA, CNAM, Paris 13 University, CRNH-IdF, Bobigny, France.
authors.forename: E
authors.initials: E
authors.lastname: Kesse-Guyot
authors.affiliation: Sorbonne Paris Cité, Nutritional Epidemiology Research Unit-UMR U557 INSERM, U1125 INRA, CNAM, Paris 13 University, CRNH-IdF, Bobigny, France.
authors.forename: F
authors.initials: F
authors.lastname: Bellisle
authors.affiliation: 1] INSERM U1016, CNRS UMR 8104, University of Paris-Descartes, Cochin Institute, Paris, France [2] AP-HP, Nutrition Department, Ambroise Paré Hospital, Boulogne-Billancourt, France.
authors.forename: C
authors.initials: C
authors.lastname: Carette
authors.affiliation: 1] AP-HP, Nutrigenic unit, Endocrinology and Oncology Biochemistry Department, Pitié-Salpêtrière Hospital, Pierre and Marie Curie university - Paris 6, Paris, France [2] INSERM U773, Digestive Physiology and Neuroendocrinology team, CRB3, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Le Beyec
authors.affiliation: 1] Sorbonne Paris Cité, Nutritional Epidemiology Research Unit-UMR U557 INSERM, U1125 INRA, CNAM, Paris 13 University, CRNH-IdF, Bobigny, France [2] Department of Public Health, Avicenne Hospital (AP-HP), Bobigny, France.
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.affiliation: 1] Institute of cardiometabolism and nutrition (ICAN), Pitié Salpêtriére hospital, Paris, France [2] Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Nutrition and Endocrinology Department, Heart and Metabolism Division, Paris, France [3] INSERM U872, Team Nutriomique, Paris, France [4] Pierre and Marie Curie University - Paris 6, Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: Clément
authors.affiliation: 1] AP-HP, Nutrition Department, Ambroise Paré Hospital, Boulogne-Billancourt, France [2] INSERM U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France [3] University of Versailles Saint Quentin en Yvelines, Boulogne-Billancourt, France.
authors.forename: S
authors.initials: S
authors.lastname: Czernichow
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D004435:Eating / Q000235:genetics / Q000523:psychology*; D002149:Energy Intake / Q000235:genetics; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009765:Obesity / Q000235:genetics / Q000523:psychology*; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D011795:Surveys and Questionnaires
chemical_list: D020738:Leptin; C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4; D011956:Receptors, Cell Surface