title: Acute and subchronic toxicity of Chantaleela recipe in rats.
abstract: Acute and subchronic toxicities of Chantaleela recipe were studied in both male and female rats. Oral administration of the extract at a single dose of 5,000 mg/kg body weight (5 females, 5 males) did not produce signs of toxicity, behavioral changes, mortality or differences on gross appearance of internal organs. The subchronic toxicity was determined by oral feeding the test substance at the doses of 600, 1,200 and 2,400 mg/kg body weight for 90 days (10 females, 10 males). No signs of abnormalities were observed in the test groups as compared to the controls. The test and control groups (on the 90(th) day) and the satellite group (on the 118(th) day) were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematological parameters, blood clinical chemistry and histopathology features. The results suggest that Chantaleela recipe did not cause acute or subchronic oral toxicities to female and male rats.
authors.affiliation: Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
authors.forename: Seewaboon
authors.initials: S
authors.lastname: Sireeratawong
authors.forename: Nattakarn
authors.initials: N
authors.lastname: Chiruntanat
authors.forename: Urarat
authors.initials: U
authors.lastname: Nanna
authors.forename: Nirush
authors.initials: N
authors.lastname: Lertprasertsuke
authors.forename: Supachai
authors.initials: S
authors.lastname: Srithiwong
authors.forename: Noppamas
authors.initials: N
authors.lastname: Soonthornchareonnon
authors.forename: Kanjana
authors.initials: K
authors.lastname: Jaijoy
mesh_terms: D000818:Animals; D005260:Female; D019684:Magnoliopsida / Q000009:adverse effects; D008297:Male; D008519:Medicine, Traditional / Q000009:adverse effects; D008517:Phytotherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013785:Thailand; D018675:Toxicity Tests
chemical_list: D010936:Plant Extracts
keywords: Acute toxicity; Chantaleela recipe; Subchronic toxicity