title: EBV-associated colonic B-cell lymphoma following treatment with infliximab for IBD: a new problem?
abstract: Patients with inflammatory bowel disease who do not respond to steroid therapy often require treatment with immunomodulators in an attempt to achieve a response and maintain remission. However, a major concern and controversy is whether these treatments are putting the patients at a significantly increased risk of developing lymphomas. This case reports a patient with severe ulcerative colitis who had been previously treated with azathioprine and infliximab, and subsequently developed diffuse large B-cell colonic lymphoma.
authors.affiliation: Department of Gastroenterology, Ulster Hospital, Belfast, UK.
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Allen
authors.forename: Georgina
authors.initials: G
authors.lastname: Laing
authors.forename: Aoife
authors.initials: A
authors.lastname: Connolly
authors.forename: Ciaran
authors.initials: C
authors.lastname: O'Neill
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000139:chemically induced* / Q000175:diagnosis; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D004854:Herpesvirus 4, Human; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D000069285:Infliximab; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D012812:Sigmoidoscopy; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab