title: Idiopathic intracranial hypertension: a possible complication in the natural history of advanced prostate cancer.
abstract: Idiopathic intracranial hypertension is a variety of intracranial hypertension that is extremely rare in men. Obesity and hypogonadism are the most important predictive factors. Etiological hypotheses include increased central venous pressure, and various hormonal and metabolic changes commonly found in obese patients. We described the case of an obese man with prostate cancer who showed a consistent bodyweight increase during treatment with taxanes and prednisone. He was hospitalized because of a severe loss of vision as a consequence of idiopathic intracranial hypertension. A complete symptom remission was obtained after 3 weeks of anti-edema therapies (steroids, acetazolamide). Castration-resistant prostate cancer is a risk factor for idiopathic intracranial hypertension. Long-term androgen deprivation therapy, bodyweight increase, and fluid retention during chronic steroid administration and taxane chemotherapy might favor the disease onset. This severe complication has a good outcome, and should be suspected in the presence of symptoms and signs of intracranial hypertension.
authors.affiliation: Department of Medical Oncology, University of Brescia, Spedali Civili Hospital, Brescia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Valcamonico
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Arcangeli
authors.forename: Francesca
authors.initials: F
authors.lastname: Consoli
authors.forename: Daniela
authors.initials: D
authors.lastname: Nonnis
authors.forename: Salvatore
authors.initials: S
authors.lastname: Grisanti
authors.forename: Enza
authors.initials: E
authors.lastname: Gatti
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berruti
authors.forename: Vittorio
authors.initials: V
authors.lastname: Ferrari
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications*; D011559:Pseudotumor Cerebri / Q000209:etiology*
keywords: castration-resistant disease; idiopathic intracranial hypertension; prostate cancer