title: Evaluation of the efficacies of Amphotericin B, Posaconazole, Voriconazole, and Anidulafungin in a murine disseminated infection by the emerging opportunistic Fungus Sarocladium (Acremonium) kiliense.
abstract: We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-d-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-d-glucan serum levels were equally reduced by all drugs evaluated.
authors.affiliation: Unitat d'Anatomia Patològica.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Fernández-Silva
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Pilar
authors.initials: P
authors.lastname: Hernández
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000164:Acremonium / Q000187:drug effects* / Q000472:pathogenicity*; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D000077612:Anidulafungin; D065819:Voriconazole