title: Relationship between insulin resistance, dyslipidaemia and positive symptom in Chinese antipsychotic-naive first-episode patients with schizophrenia.
abstract: Controversial results concerning insulin resistance and lipid metabolism have been reported in antipsychotic-naive first-episode psychosis (AN-FEP) patients with schizophrenia of different countries. We aimed at determining whether schizophrenia-related psychopathology was associated with insulin resistance and/or dyslipidaemia in Chinese patients with AN-FEP schizophrenia. A cross-sectional study was performed in Chinese patients newly diagnosed with schizophrenia (n = 49, antipsychotic-naïve or antipsychotic medications< 2 weeks) and healthy volunteers (n = 30). The serum levels of insulin and triglyceride levels as well as homeostasis model of assessment-insulin resistance (HOMA-IR) index were significantly increased in AN-FEP patients, when compared with healthy volunteers. The gender difference had a significant impact on the insulin resistance and dyslipidaemia in these AN-FEP subjects. Multiple linear regression analysis demonstrated that the severity of positive symptoms of schizophrenia was negatively related to insulin resistance. No difference of serum glucose level, total cholesterol content, body mass index (BMI) and smoking status was detected between patients with schizophrenia and healthy controls. In conclusion, Chinese AN-FEP patients were more prone to insulin resistance and dyslipidaemia as compared to the healthy population, which is negatively correlated to positive symptoms. The results may contribute to the understanding of the relationship between the glucose/lipidaemia metabolic dysfunction and the psychopathology in patients with schizophrenia.
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Beijing, 100906, PR China.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.forename: Dong
authors.initials: D
authors.lastname: Broqueres-You
authors.forename: Guigang
authors.initials: G
authors.lastname: Yang
authors.forename: Zhiren
authors.initials: Z
authors.lastname: Wang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Fude
authors.initials: F
authors.lastname: Yang
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Tan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000208:ethnology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000208:ethnology*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D011599:Psychopathology; D011618:Psychotic Disorders / Q000188:drug therapy; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood* / Q000208:ethnology* / Q000473:pathology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D007328:Insulin; D002784:Cholesterol; D005947:Glucose
keywords: Antipsychotic-naive first-episode psychosis schizophrenia; Dyslipidaemia; Insulin resistance; Psychopathology