title: Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients.
abstract: In stroke-like episodes (SEs) of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), the detection of preclinically latent lesions is a challenge. We report regional cerebral hyperperfusion observed on arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in the preclinical phase more than 3 months before the clinical onset of SEs in 3 MELAS patients. These hyperperfused areas were not detected by conventional MRI in the preclinical phase and developed into acute lesions at the clinical onset of SEs, suggesting that ASL imaging has the potential for predicting the emergence of SEs.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaiduki, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoneda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsunaga
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kosaka
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamamura
authors.forename: Tadanori
authors.initials: T
authors.lastname: Hamano
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000150:complications / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D020521:Stroke / Q000209:etiology*; D055815:Young Adult
chemical_list: D013113:Spin Labels
keywords: (123)I-IMP; A-to-G transition at nucleotide position 3243; A3243G; ASL; Arterial spin labeling; CBF; DWIs; FLAIR; MELAS; MRA; MRI; MRS; N-isopropyl-p-[(123)I]iodoamphetamine; PET; Perfusion imaging; SEs; SPECT; Stroke-like episodes; arterial spin labeling; cerebral blood flow; diffusion-weighted images; fluid-attenuated inversion recovery; magnetic resonance angiography; magnetic resonance imaging; magnetic resonance spectroscopy; mitochondrial DNA; mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes; mtDNA; positron emission tomography; rCBF; regional cerebral blood flow; single-photon emission computed tomography; stroke-like episodes