title: pLogo: a probabilistic approach to visualizing sequence motifs.
abstract: Methods for visualizing protein or nucleic acid motifs have traditionally relied upon residue frequencies to graphically scale character heights. We describe the pLogo, a motif visualization in which residue heights are scaled relative to their statistical significance. A pLogo generation tool is publicly available at http://plogo.uconn.edu/ and supports real-time conditional probability calculations and visualizations.
authors.affiliation: 1] Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA. [2].
authors.forename: Joseph P
authors.initials: JP
authors.lastname: O'Shea
authors.forename: Michael F
authors.initials: MF
authors.lastname: Chou
authors.forename: Saad A
authors.initials: SA
authors.lastname: Quader
authors.forename: James K
authors.initials: JK
authors.lastname: Ryan
authors.forename: George M
authors.initials: GM
authors.lastname: Church
authors.forename: Daniel
authors.initials: D
authors.lastname: Schwartz
mesh_terms: D000465:Algorithms; D020816:Amino Acid Motifs; D000818:Animals; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D023281:Genomics; D006801:Humans; D051379:Mice; D015233:Models, Statistical; D009696:Nucleic Acids / Q000737:chemistry*; D010766:Phosphorylation; D011336:Probability; D011506:Proteins / Q000737:chemistry*; D020543:Proteome; D040901:Proteomics / Q000379:methods; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D019061:src-Family Kinases / Q000737:chemistry
chemical_list: D009696:Nucleic Acids; D011506:Proteins; D020543:Proteome; D019061:src-Family Kinases