title: Hepatotoxicity and drug interactions in liver transplant candidates and recipients.
abstract: In this article the medications that have been shown to increase rates of drug-induced liver injury in patients with cirrhosis and the important drug-drug interactions in recipients of liver transplantation are reviewed. In general, the risk of drug-induced liver injury in patients with cirrhosis does not seem to be higher when compared with the noncirrhotic population. There are, however, 2 classes of agents that have been implicated-medications used to treat tuberculosis and medications used to treat human immunodeficiency virus infection. However, with careful monitoring, even significant interactions can be effectively managed.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion 19th Floor, 676 North Saint Clair Street, Suite 1900, Chicago IL 60611, USA.
authors.forename: Neehar D
authors.initials: ND
authors.lastname: Parikh
authors.forename: Josh
authors.initials: J
authors.lastname: Levitsky
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000494:pharmacology; D016031:Liver Transplantation; D011480:Protease Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D014180:Transplantation
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D011480:Protease Inhibitors
keywords: Calcineurin; DILI; Immunosuppressives; Medication