title: Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats.
abstract: OBJECTIVE
  To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats, and to investigate a novel solution to multiple organ dysfunction syndrome.
  
  
  METHODS
  Multiple organ dysfunction syndrome was induced in 60 Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and puncture. Then these rats were intragastrically administered physiological saline (group I, n=20), ampicillin (group II, n=20) or intestinal function-recovering decoction (group III, n=20). After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously, bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were observed.
  
  
  RESULTS
  Compared with group I, serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased (all P<0.05) and serum superoxide dismutase level was significantly increased (P<0.05) in the group III. However, there were no significant differences in these indices between groups II and III (P>0.05). The rate of bacterial translocation in the groups II and III was significantly lower than in the group I (P<0.05), and no significant difference was observed between groups II and III (P>0.05).
  
  
  CONCLUSIONS
  Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.
authors.affiliation: Intensive Care Unit, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Shu-Jie
authors.initials: SJ
authors.lastname: Zhao
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Shi-Ji
authors.initials: SJ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Han
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Wang
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018988:Bacterial Translocation; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004731:Endotoxins / Q000097:blood; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000382:microbiology / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009102:Multiple Organ Failure / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D008315:Malondialdehyde; D000667:Ampicillin; D013482:Superoxide Dismutase
keywords: Intestinal function–recovering decoction; Malondialdehyde; Multiple organ dysfunction syndrome; Superoxide dismutase