title: Hepatitis B virus gene mutations and hepatocarcinogenesis.
abstract: Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These variations include, in particular, mutations in ORF S,C,X gene regions. This mini-review summarizes results of clinical studies and molecular mechanisms on the possible relations of HBV mutations with the development of hepatocellular carcinoma.
authors.affiliation: Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China E-mail : htang6198@hotmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Liang
authors.forename: En-Qiang
authors.initials: EQ
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000473:pathology; D005814:Genes, Viral / Q000235:genetics*; D006509:Hepatitis B / Q000150:complications* / Q000235:genetics / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D009154:Mutation / Q000235:genetics*