title: Effect of lighting conditions on brain network complexity associated with response learning.
abstract: Several studies have reported the brain regions involved in response learning. However, there is discrepancy regarding the lighting conditions in the experimental setting (i.e. under dark or light conditions). In this regard, it would be relevant to know if the presence/absence of visual cues in the environment has any effect in the brain networks involved in a response learning task. Animals were trained in a water T-maze under two different lighting conditions (light versus dark). All subjects reached the learning criterion of 80% correct arm choices. Quantitative cytochrome oxidase (CO) histochemistry was used as a metabolic brain mapping technique. Our results show that the ventral hippocampus and the parietal cortex are associated with the acquisition of a response learning task regardless of lighting conditions. In addition, when the same task is run in the dark, widespread recruitment of structures involving cortical, limbic and striatal regions was found.
authors.affiliation: Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, Plaza Feijóo s/n, 33003 Oviedo, Spain. Electronic address: alvarezcamino@uniovi.es.
authors.forename: Camino
authors.initials: C
authors.lastname: Fidalgo
authors.forename: Nélida M
authors.initials: NM
authors.lastname: Conejo
authors.forename: Héctor
authors.initials: H
authors.lastname: González-Pardo
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Arias
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000502:physiology*; D003624:Darkness; D003576:Electron Transport Complex IV / Q000378:metabolism; D007858:Learning / Q000502:physiology*; D008029:Lighting; D008297:Male; D018782:Maze Learning; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time
chemical_list: D003576:Electron Transport Complex IV
keywords: Brain networks; Cytochrome oxidase; Rat; Spatial memory; T-maze