title: Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome.
abstract: BACKGROUND
  The basic studies showed that Pigment epithelium-derived factor (PEDF) plays an important role in inflammation.
  
  
  OBJECTIVE
  This study aims to investigate the association of serum PEDF with high-sensitivity C-reactive protein (hs-CRP) in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Ninety-six PCOS women and 63 healthy, age-matched controls were enrolled in this study. Serum levels of PEDF, hs-CRP, Complement C3 (C3), glucose, insulin, lipids, and total testosterone were measured. Ninety-six PCOS women and 20 controls underwent hyperinsulinemiceuglycemic clamp to assess their insulin sensitivity, which was expressed as M value.
  
  
  RESULTS
  Serum PEDF levels and hs- CRP levels were much higher in PCOS women than in controls. In PCOS women, PEDF positively correlated with body mass index (BMI), hs-CRP, C3, LDL cholesterol (LDL-c), and systolic blood pressure (SBP), and negatively correlated with M value and HDL cholesterol (HDL-c). After controlling for BMI, PEDF was still positively correlated with hs-CRP. Multiple linear regression analysis revealed that in PCOS women, hs-CRP, SBP, LDL-c and M value were independent determinants of serum PEDF.
  
  
  CONCLUSIONS
  The serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Cheng
authors.forename: W
authors.initials: W
authors.lastname: Xia
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Ye
authors.forename: M
authors.initials: M
authors.lastname: Mei
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.forename: Q
authors.initials: Q
authors.lastname: Li
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D009414:Nerve Growth Factors / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D015843:Serpins / Q000097:blood*; D013739:Testosterone / Q000097:blood; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D002097:C-Reactive Protein; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005136:Eye Proteins; D007328:Insulin; D009414:Nerve Growth Factors; D015843:Serpins; D013739:Testosterone; D000099174:Pigment Epithelium-Derived Factor