title: Evaluation of safety and efficacy of purgative manna (billinaster drop) and glycerin suppository in icterus of healthy term newborns.
abstract: OBJECTIVE
  The aim of the present study was to investigate safety and efficacy of billinaster drop and glycerin suppository in hyperbilirubinemia of healthy term newborns who had passage of first meconium.
  
  
  METHODS
  In a randomized clinical trial, 90 neonates with total plasma bilirubin(TPB) level of 15-20mg/dL, were randomly assigned to be treated with alone phototherapy (control) or 5drop/kg of bilinaster drop every eight hours and phototherapy(B) or half of glycerin suppository every twelve hours and phototherapy(G). The primary outcomes were safety of drugs and efficacy in obtaining TPB of less than 14 mg/dL as measured at the beginning, 12, 24 and 48 hours after intervention. Secondary endpoint was hospitalization days.
  
  
  RESULTS
  After 48 hours of intervention, achieving TPB of less than 14 mg/dL was seen in 50 %( N=15) in control group, 73.3 %( N=22) in B group and 86.7 %( N=26 neonates) in G group (P= 0.01). Watery stool was seen in two neonates of glycerin group and safety of the treatments was not significantly different. Mean of TPB 12 hours after beginning of phototherapy(mean±SD:14.38±2.27mg/dL in G, 15.97±1.96mg/dL in B and 16.67±1.77mg/dL in control), 24 hours after intervention(mean±SD:12.56 ±1.59mg/dL in G, 12.57±2.05mg/dL in B and 14.36±2.26mg/dL in control), 48 hours after intervention (mean±SD: 9.34 ± 1.6mg/dL in G, 9.96 ± 2.95mg/dL in B and 12.27 ± 2.4mg/dL in control) and mean of hospitalization days (mean± SD: 1.5 ± 0.4days in G, 1.7 ± 0.4days in B and 2.9 ± 1.1days in control) were significantly lower in glycerin and billinaster groups.
  
  
  CONCLUSIONS
  Bilinaster drop and glycerin suppository can be used as hazardless, efficient and cost effective drugs in treatment of neonatal hyperbilirubinemia.
authors.forename: Razieh
authors.initials: R
authors.lastname: Fallah
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Fallahzadeh
authors.affiliation: Shahid Sadoughi Hospital, Ave - Sina Blvd, Shahid Ghandi Blvd, Yazd, I.R. Iran. mahmood_7072005@yahoo.com.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Noori-Shadkam
mesh_terms: D001663:Bilirubin / Q000032:analysis; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D045424:Complex Mixtures / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D004311:Double-Blind Method; D023381:Endpoint Determination; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000188:drug therapy; D007231:Infant, Newborn; D007565:Jaundice / Q000188:drug therapy* / Q000628:therapy; D007902:Length of Stay; D008297:Male; D010789:Phototherapy; D016037:Single-Blind Method; D013488:Suppositories
chemical_list: D002400:Cathartics; D045424:Complex Mixtures; D013488:Suppositories; C000592732:purgative manna; D005990:Glycerol; D001663:Bilirubin