title: Genetic polymorphism of matrix metalloproteinase family and chronic obstructive pulmonary disease susceptibility: a meta-analysis.
abstract: Matrix metalloproteinase (MMP) family is considered to be associated with chronic obstructive pulmonary disease (COPD) pathogenesis, however, no consistent results have been provided by previous studies. In this report, we performed Meta analysis to investigate the association between four kinds of MMP single nucleotide polymorphisms (SNP, MMP1 -1607 1G/2G, MMP3 -1171 5A/6A, MMP9 -1562 C/T, MMP12 -82 A/G) and COPD risk from 21 studies including 4184 cases and 5716 controls. Both overall and subgroup association between SNP and COPD susceptibility were tested. There was no evident association between MMP polymorphisms and COPD susceptibility in general population. On the other hand, subgroup analysis suggested that MMP9 -1562 C/T polymorphism was related to COPD, as we found that C allele carriers were at lower risk in some subgroups stratified by lung function, age and genotype identification method, compared with TT homozygotes. Our results indicated the genotype TT might be one genetic risk factor of severe COPD.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhou
authors.forename: Yinfang
authors.initials: Y
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Jiesen
authors.initials: J
authors.lastname: Zhou
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Luanqing
authors.initials: L
authors.lastname: Che
authors.forename: Jiyong
authors.initials: J
authors.lastname: Jing
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Huahao
authors.initials: H
authors.lastname: Shen
mesh_terms: D000483:Alleles; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D005810:Multigene Family; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000378:metabolism
chemical_list: D020782:Matrix Metalloproteinases