title: Your gut is right to turn left.
abstract: Transcriptional factor Pitx2 is a key regulator of left-right asymmetry in the developing gut. In this issue of Developmental Cell, Welsh et al. (2013) identify the formin Daam2, an effector of Wnt signaling, as a key cellular target of Pitx2 required for morphogenetic events during asymmetric gut formation.
authors.affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Klezovitch
authors.forename: Valeri
authors.initials: V
authors.lastname: Vasioukhin
mesh_terms: D000818:Animals; D054262:Gastrulation; D018398:Homeodomain Proteins / Q000378:metabolism*; D007422:Intestines / Q000196:embryology*; D008840:Microfilament Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D060449:Wnt Signaling Pathway; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D000097577:Homeobox Protein PITX2
chemical_list: D018398:Homeodomain Proteins; D008840:Microfilament Proteins; D014157:Transcription Factors; D020741:rho GTP-Binding Proteins; D000097577:Homeobox Protein PITX2; C500366:Daam2 protein, mouse