title: A prospective, comparative, observational study on optical coherence tomography of the anterior eye segment.
abstract: BACKGROUND
  We compared two commercially available spectral-domain optical coherence tomography (OCT) devices according to their capacity of imaging the anterior segment of the eye with the same detail and quality.
  
  
  METHODS
  A prospective, observational, single-visit study with individuals aged 18 years and older was conducted on two different OCT devices: the Spectralis™ OCT and the RTVue™ OCT. The resulting OCT images of both study devices of each study subject were compared and qualified by a single investigator according to the identification of corresponding structures and pathologies (primary endpoint) and the comparability of the clinical information given (secondary endpoint).
  
  
  RESULTS
  We included 28 eyes (28 patients) in our study, e.g. 8 normal eyes, 7 of subjects with corneal disease, 8 eyes with chamber angle pathology and 5 cases with pathology of the sclera. Of all anterior segment structures analyzed, 93.9% were identified by Spectralis™ OCT and 91.2% were detected by RTVue® OCT with a high positive correlation (r = 0.996; p < 0.0001) between the two devices.
  
  
  CONCLUSIONS
  The majority of clinically relevant structures could be identified with both devices in all subjects. The Spectralis OCT tended to perform better in the illustration of deep anterior segment structures like the ciliary body and sclera.
authors.affiliation: Department of Ophthalmology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Theelen
authors.forename: Carel B
authors.initials: CB
authors.lastname: Hoyng
mesh_terms: D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D003316:Corneal Diseases / Q000175:diagnosis*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D015422:Scleral Diseases / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*