title: Large-scale study of long non-coding RNA functions based on structure and expression features.
abstract: Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, we focus on the current methods for analyzing lncRNA structure and expression, which is basic but necessary information for in-depth, large-scale analysis of lncRNA functions.
authors.affiliation: Bioinformatics Research Group, Advanced Computing Research Laboratory, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Chen
authors.forename: Haitao
authors.initials: H
authors.lastname: Luo
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Rensheng
authors.initials: R
authors.lastname: Chen
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D059370:RNA Folding; D062085:RNA, Long Noncoding / Q000737:chemistry* / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding