title: Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases.
abstract: BACKGROUND
  Benign lymphangioendothelioma represents a rare lymphatic vascular proliferation characterized by proliferation of irregular and thin-walled vessels dissecting amongst dermal collagen. Immunohistochemical analysis has been lacking in most previously reported cases.
  
  
  METHODS
  Herein, we report the clinical and histopathologic characteristics of four cases of benign lymphangioendothelioma. Immunohistochemical study was completed for all lesions.
  
  
  RESULTS
  All lesions presented as large, red to brown patches or plaques. Three lesions were located on the thigh and one lesion was located on the neck. Histopathologically, all lesions showed proliferation of anastomotic or retiform thin-walled vessels with a single layer of endothelial cells that dissect the dermis. D2-40 and Prox1 immunostains were positive and Wilms tumor 1 (WT-1) immunostain was negative in all cases.
  
  
  CONCLUSIONS
  Benign lymphangioendothelioma represents a lymphatic vascular proliferation. A lack of expression of WT-1 suggests it represents a lymphatic vascular malformation.
authors.affiliation: Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xian, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Liuqing
authors.initials: L
authors.lastname: Chen
authors.forename: Xichuan
authors.initials: X
authors.lastname: Yang
authors.forename: Tianwen
authors.initials: T
authors.lastname: Gao
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008202:Lymphangioma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009333:Neck / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013848:Thigh / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: D2-40; Prox 1; Wilms tumor 1; acquired progressive lymphangioma; benign lymphangioendothelioma; vascular malformation