title: Function-first antibody discovery: Embracing the unpredictable biology of antibodies.
abstract: Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a "function-first" target and drug discovery platform in which antibodies against a multitude of tumor-associated antigens are screened for biological effects in a target-unbiased manner.
authors.affiliation: BioInvent International AB; Lund, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Frendéus
keywords: ICAM-1; IRST; antibody biology; antibody discovery; cancer; drug development; function-first; myeloma; target discovery; therapeutic antibody