title: The Semaphorin 3E/PlexinD1 axis regulates macrophage inflammation in obesity.
abstract: Increased accumulation of adipose tissue macrophages in obesity propagates chronic inflammation that is closely associated with insulin resistance and type 2 diabetes. Semaphorin 3E, a guidance molecule for neurons, takes on a new role in obesity by directing the recruitment of macrophages in visceral adipose tissue (Shimizu et al., 2013).
authors.affiliation: Diabetes Research Program, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Moore
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D007249:Inflammation / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; C473552:Plxnd1 protein, mouse; D039961:Semaphorins