title: Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles.
abstract: Stearic acid-grafted chitosan (CS-SA) and glycyrrhetinic acid-conjugated stearic acid-grafted chitosan (GA-CS-SA) were synthesized and were further used for the preparation of micelles. The substitution degree (SD) of SA and GA on CS was measured. The physicochemical properties of CS-SA and GA-CS-SA micelles such as critical micelle concentration (CMC), aggregation number of hydrophobic micro-domain (AN), particle size, zeta potential, and morphology were also determined. The CMC of GA-CS-SA was about 17.49 μg/mL, which was relatively low. Its AN was 2.09. The GA-CS-SA micelles showed spherical shape with mean diameter of 121.1 nm and had positive charge, which suggested that GA-CS-SA could be a good carrier of cancer drug.
authors.affiliation: School of Pharmacy, Qingdao University , Qingdao , P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Jiangjun
authors.initials: J
authors.lastname: Wang
authors.forename: Guowen
authors.initials: G
authors.lastname: Yan
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Cui
authors.forename: Hongli
authors.initials: H
authors.lastname: Yin
authors.forename: Haitian
authors.initials: H
authors.lastname: Wei
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D006034:Glycyrrhetinic Acid / Q000737:chemistry*; D008823:Micelles; D013229:Stearic Acids / Q000737:chemistry*
chemical_list: D008823:Micelles; D013229:Stearic Acids; C031183:stearic acid; D048271:Chitosan; D006034:Glycyrrhetinic Acid
keywords: chitosan; glycyrrhetinic acid; micelle; targeting