title: Control of the hematopoietic stem cell state.
abstract: Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin, but also subject to developmental and other, as yet undefined, cues.
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada V5Z 1L3.
authors.forename: David Jhf
authors.initials: DJ
authors.lastname: Knapp
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada V5Z 1L3.
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Eaves
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D002454:Cell Differentiation; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008297:Male