title: In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents.
abstract: Previously, pulsed magneto-motive ultrasound (pMMUS) imaging has been introduced as a contrast-agent-assisted ultrasound-based imaging modality capable of visualizing biological events at the cellular and molecular level. In pMMUS imaging, a high intensity pulsed magnetic field is used to excite cells or tissue labeled with magnetic nanoparticles. Then, ultrasound (US) imaging is used to monitor the mechanical response of the tissue to an externally applied magnetic field (i.e., tissue displacement). Signal to noise ratio (SNR) in pMMUS imaging can be improved by using superparamagnetic nanoparticles with larger saturation magnetization. Metal-doped magnetic nanoparticles with enhanced tunable nanomagnetism are suitable candidates to improve the SNR and, therefore, sensitivity of pMMUS imaging, which is essential for in vivo pMMUS imaging. In this study, we demonstrate the capability of pMMUS imaging to identify the presence and distribution of zinc-doped iron oxide nanoparticles in live nude mice bearing A431 (human epithelial carcinoma) xenograft tumors.
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA. emelian@mail.utexas.edu.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mehrmohammadi
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Shin
authors.forename: Min
authors.initials: M
authors.lastname: Qu
authors.forename: Pieter
authors.initials: P
authors.lastname: Kruizinga
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Truby
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
authors.forename: Stanislav Y
authors.initials: SY
authors.lastname: Emelianov
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000000981:diagnostic imaging*; D014183:Transplantation, Heterologous; D014463:Ultrasonography; D015032:Zinc / Q000737:chemistry
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D015032:Zinc