title: Abnormal cardiac enzymes in systemic sclerosis: a report of four patients and review of the literature.
abstract: Cardiac involvement in systemic sclerosis (SSc) is heterogeneous and can include primary involvement of the myocardium, pericardium and coronary arteries or be secondary to cardiac complications of pulmonary and renal disease. Primary cardiac involvement in SSc is uncommon but can result in ventricular dysfunction, organ failure, arrhythmias and death. It can remain clinically silent and the prevalence is likely to be under-reported. We report four cases of SSc associated with a raised serum troponin T (TnT), in a proportion of whom cardiac MRI myocardial abnormalities were detected. These cases highlight the heterogeneity of cardiac involvement in SSc, the role of cardiac MRI and promising biochemical responses to immunosuppression. Cardiac biomarkers such as TnT may be useful screening tools to identify subclinical cardiac disease and assess response to therapeutic intervention.
authors.affiliation: Royal National Hospital for Rheumatic Diseases, Bath, BA1 1RL, UK.
authors.forename: B
authors.initials: B
authors.lastname: Vasta
authors.forename: V
authors.initials: V
authors.lastname: Flower
authors.forename: C
authors.initials: C
authors.lastname: Bucciarelli-Ducci
authors.forename: S
authors.initials: S
authors.lastname: Brown
authors.forename: E
authors.initials: E
authors.lastname: Korendowych
authors.forename: N J
authors.initials: NJ
authors.lastname: McHugh
authors.forename: J D
authors.initials: JD
authors.lastname: Pauling
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D012595:Scleroderma, Systemic / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T