title: [Informativeness of genetic factors for optimization of personalized therapy with clopidogrel].
abstract: We studied occurrence of allele variants *1, *2, *3, and *17 of CYP2C19 gene and polymorphic variants of ABCB1 gene in clopidogrel treated patients from West Siberian and Far Eastern regions and determined contribution of these polymorphisms to laboratory efficacy of clopidogrel. In dependence on magnitude of change of platelet aggregation we distinguished groups of patients with different sensitivity to clopidogrel. We found association between polymorphic variant CYP2C19*2 with changes of platelet aggregation after administration of clopidogrel. An additional group of patients with augmented platelet aggregation after administration of clopidogrel was detected. There was no correlation between the latter effect and any of studied polymorphisms.
authors.affiliation: Academian E.N. Meshalkin Novosibirsk State Research Institute of Circulation Pathology, ul. Rechkunovskaya 15, 630055 Novosibirsk, Russia.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Knauér
authors.forename: G I
authors.initials: GI
authors.lastname: Lifshits
authors.forename: E N
authors.initials: EN
authors.lastname: Voronina
authors.forename: N V
authors.initials: NV
authors.lastname: Koleda
authors.forename: E V
authors.initials: EV
authors.lastname: Gus'kova
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics; D000077144:Clopidogrel; D065731:Cytochrome P-450 CYP2C19; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D010974:Platelet Aggregation / Q000187:drug effects / Q000235:genetics; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism / Q000494:pharmacology; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D012800:Siberia; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D013988:Ticlopidine