title: Myoglobin removal using high-volume high-flux hemofiltration in patients with oliguric acute kidney injury.
abstract: BACKGROUND
  Rhabdomyolysis can cause acute kidney injury (AKI). It remains controversial whether or not myoglobin can be removed from the circulation with extracorporeal therapy and decrease the incidence of AKI. Therefore, we examined myoglobin removal in a series of 11 patients with oliguric AKI treated with high-volume hemofiltration.
  
  
  METHODS
  Patients received prefilter hemofiltration using a polysulphone filter with a molecular size cutoff of 65 kDa and a surface area of 1.7 m(2). Sieving coefficients and myoglobin clearances were calculated at 6, 12, and 24 h after the start of hemofiltration.
  
  
  RESULTS
  The mean sieving coefficient was 0.158, and the mean myoglobin clearance was 8.7 ml/min.
  
  
  CONCLUSIONS
  Despite the use of high-volume hemofiltration, the removal of myoglobin was negligible. In patients with normal renal function, the anticipated amount of extracorporeal removal would not significantly impact renal exposure to myoglobin.
authors.affiliation: Division of Renal Diseases and Hypertension, Division of Pediatric Nephrology, Departments of Internal Medicine and Pediatrics, UT Health Science Center at Houston, Medical School, Houston, Tex., USA.
authors.forename: Nelio
authors.initials: N
authors.lastname: Guzman
authors.forename: Amber S
authors.initials: AS
authors.lastname: Podoll
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Bell
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Finkel
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000150:complications / Q000209:etiology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D009212:Myoglobinuria / Q000628:therapy; D009846:Oliguria / Q000209:etiology; D011446:Prospective Studies; D012206:Rhabdomyolysis / Q000150:complications; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009211:Myoglobin