title: The new French 2010 Rabbit Hemorrhagic Disease Virus causes an RHD-like disease in the Sardinian Cape hare (Lepus capensis mediterraneus).
abstract: Lagovirus is an emerging genus of Caliciviridae, which includes the Rabbit Hemorrhagic Disease Virus (RHDV) of rabbits and the European brown hare syndrome virus (EBHSV) of hares that cause lethal hepatitis. In 2010, a new RHDV related virus (RHDV2) with a unique genetic and antigenic profile and lower virulence was identified in France in rabbits. Here we report the identification of RHDV2 as the cause in Sardinia of several outbreaks of acute hepatitis in rabbits and Cape hare (Lepus capensis mediterraneus). This is the first account of a lagovirus that causes fatal hepatitis in both rabbits and hares.
authors.affiliation: Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, OIE Reference Laboratory for RHD, via Bianchi 9, 25124 Brescia, Italy. lorenzo.capucci@izsler.it.
authors.forename: Giantonella
authors.initials: G
authors.lastname: Puggioni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cavadini
authors.forename: Caterina
authors.initials: C
authors.lastname: Maestrale
authors.forename: Rosario
authors.initials: R
authors.lastname: Scivoli
authors.forename: Giuliana
authors.initials: G
authors.lastname: Botti
authors.forename: Ciriaco
authors.initials: C
authors.lastname: Ligios
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Le Gall-Reculé
authors.forename: Antonio
authors.initials: A
authors.lastname: Lavazza
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Capucci
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary* / Q000821:virology; D045303:Cytochromes b / Q000235:genetics / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D034621:Hares; D017929:Hemorrhagic Disease Virus, Rabbit / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007558:Italy / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D020539:Sequence Analysis, Protein / Q000662:veterinary; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D015678:Viral Structural Proteins; C081149:viral protein 60, rabbit hemorrhagic disease virus; D045303:Cytochromes b; D003576:Electron Transport Complex IV