title: Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector.
abstract: The feasibility of a new method of quickly acquiring interstitial fluid (ISF) samples using a Lorentz-force actuated needle-free jet injector is demonstrated on ex vivo porcine tissue. The jet injector is used to first inject a small volume of physiological saline to breach the skin, and the back-drivability of the actuator is utilized to create a vacuum in the ampoule and collect ISF. Injection and extraction parameters are tested and optimized for minimal acquired sample dilution and extracted volume consistency. Using this method, we are able to collect a sample that contains up to 3.5% ISF in 3.1 s.
authors.forename: Jean H
authors.initials: JH
authors.lastname: Chang
authors.forename: N Catherine
authors.initials: NC
authors.lastname: Hogan
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hunter
mesh_terms: D000818:Animals; D045604:Extracellular Fluid / Q000502:physiology*; D005240:Feasibility Studies; D007277:Injections, Jet / Q000295:instrumentation*; D012879:Skin Physiological Phenomena; D013552:Swine