title: Neurotransmitter receptor and regulatory gene expression in peripheral blood of Brazilian drug-naïve first-episode psychosis patients before and after antipsychotic treatment.
abstract: Little is known about how genes expressed in blood relate to schizophrenia or antipsychotic use. We analyzed gene expression in 10 first-episode psychosis patients and nine controls using PCR Arrays. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use.
authors.affiliation: Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu, 740, Edifício Leitao da Cunha, 1° andar, CEP 04023-900, São Paulo, Brazil; LiNC-Laboratório Interdisciplinar de Neurociências Clínicas, Departamento de Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, 669, 3° andar fundos, CEP 05039-032, São Paulo, Brazil. Electronic address: vanessakaota@gmail.com.
authors.forename: Vanessa Kiyomi
authors.initials: VK
authors.lastname: Ota
authors.forename: Cristiano
authors.initials: C
authors.lastname: Noto
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha
authors.forename: Marcos Leite
authors.initials: ML
authors.lastname: Santoro
authors.forename: Patricia Natalia
authors.initials: PN
authors.lastname: Silva
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Melaragno
authors.forename: Marília de Arruda Cardoso
authors.initials: Mde A
authors.lastname: Smith
authors.forename: Quirino
authors.initials: Q
authors.lastname: Cordeiro
authors.forename: Rodrigo Affonseca
authors.initials: RA
authors.lastname: Bressan
authors.forename: Sintia Iole
authors.initials: SI
authors.lastname: Belangero
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001938:Brazil; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D012333:RNA, Messenger / Q000097:blood; D011963:Receptors, GABA-A / Q000187:drug effects / Q000235:genetics*; D017981:Receptors, Neurotransmitter / Q000097:blood / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D012333:RNA, Messenger; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D011978:Receptors, Nicotinic; D018967:Risperidone; C106350:GABRR2 protein, human
keywords: CHRNA3; GABRR2; Schizophrenia