title: The antioxidant status and concentrations of coenzyme Q10 and vitamin E in metabolic syndrome.
abstract: The purpose of this study was to investigate the levels of coenzyme Q10 and vitamin E and the antioxidant status in subjects with metabolic syndrome (MS). Subjects with MS (n = 72) were included according to the criteria for MS. The non-MS group (n = 105) was comprised of healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, vitamin E concentrations, lipid profiles, and antioxidant enzymes levels (catalase, superoxide dismutase, and glutathione peroxidase) were measured. The subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the non-MS group, but these differences were not significant after being normalized for triglyceride level. The levels of antioxidant enzymes were significantly lower in the MS group than in the non-MS group. The subjects with the higher antioxidant enzymes activities had significant reductions in the risk of MS (P < 0.01) after being adjusted for coenzyme Q10 and vitamin E. In conclusion, the subjects with MS might be under higher oxidative stress resulting in low levels of antioxidant enzyme activities. A higher level of antioxidant enzymes activities was significantly associated with a reduction in the risk of MS independent of the levels of coenzyme Q10 and vitamin E.
authors.affiliation: Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan ; Center for Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung 40201, Taiwan.
authors.forename: Chi-Hua
authors.initials: CH
authors.lastname: Yen
authors.forename: Nae-Cherng
authors.initials: NC
authors.lastname: Yang
authors.forename: Bor-Jen
authors.initials: BJ
authors.lastname: Lee
authors.forename: Jui-Yuan
authors.initials: JY
authors.lastname: Lin
authors.forename: Simon
authors.initials: S
authors.lastname: Hsia
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10