title: Osteonecrosis of the jaw related to everolimus: a case report.
abstract: Antiresorptive agent-related osteonecrosis of the jaw results in appreciable morbidity in affected patients. Nowadays many physicians prescribe an antiangiogenic agent for the management of malignant metastases. Everolimus is a serine-threonine kinase that acts as an inhibitor of mammalian target of rapamycin, which results in reduced growth of cells, angiogenesis, and survival of cells. We report the first case to our knowledge of osteonecrosis of the jaw that seemed to result from the additive effect of everolimus.
authors.affiliation: Department of Oral & Maxillofacial Surgery, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Republic of Korea. Electronic address: dwkim617@gmail.com.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Jung
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Park
authors.forename: Hwi-Dong
authors.initials: HD
authors.lastname: Jung
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D004164:Diphosphonates / Q000627:therapeutic use; D000068338:Everolimus; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008336:Mandibular Diseases / Q000139:chemically induced*; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives*; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D000077211:Zoledronic Acid
chemical_list: D020533:Angiogenesis Inhibitors; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000068338:Everolimus; D020123:Sirolimus
keywords: ARONJ; Anti-angiogenic agent; Anti-resorptive agent related osteonecrosis of the jaw; Everolimus