title: Akt2 relaxes podocytes in chronic kidney disease.
abstract: A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).
authors.affiliation: Department of Medicine, Rush University, Chicago, Illinois, USA.
authors.forename: Jochen
authors.initials: J
authors.lastname: Reiser
mesh_terms: D000818:Animals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D050199:Podocytes / Q000166:cytology*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*
chemical_list: C494922:Akt2 protein, mouse; D051057:Proto-Oncogene Proteins c-akt