title: Choroidal metastasis of non-small cell lung cancer that responded to gefitinib.
abstract: A 52-year-old Japanese woman presented with optical symptoms, including left-sided myodesopsia, blurred vision, narrowed visual field, and diminished visual acuity. Ocular evaluation revealed a metastatic tumor in the choroid. Further examinations identified pulmonary adenocarcinoma as the primary tumor. Because an epidermal growth factor receptor gene (EGFR) mutation was detected in a biopsy specimen, gefitinib treatment was initiated. Dramatic responses were obtained in the primary tumor and metastatic foci. Optical symptoms improved and remained stable for 5 months during the treatment, until relapse. This report demonstrates that gefitinib is effective for choroidal metastasis of pulmonary adenocarcinoma harboring an EGFR mutation.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8677, Japan.
authors.forename: Iwao
authors.initials: I
authors.lastname: Shimomura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Gen
authors.initials: G
authors.lastname: Miura
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takuma
authors.initials: T
authors.lastname: Matsumura
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Jiro
authors.initials: J
authors.lastname: Terada
authors.forename: Ryota
authors.initials: R
authors.lastname: Kurimoto
authors.forename: Emiko
authors.initials: E
authors.lastname: Sakaida
authors.forename: Ikuo
authors.initials: I
authors.lastname: Sekine
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi