title: Spectroscopic correlation and role of Azathioprine in long-term remission in patients of Hashimoto encephalopathy.
abstract: Hashimoto encephalopathy remains a Rubik's cube for the present generation of clinical research. Myriad presentations have been noted, and observations recorded in few subgroups of patients have gone on only to be trashed by a second group of patients with a completely different clinical profile. Steroids have been traditionally held to be the treatment for this condition, but long-term side effects associated with it limits its use. Although multiple drugs have been tried, yet there exists no data for their long-term efficacy in maintaining remission. No radiological findings have been consistently associated with this condition. We report the use of azathioprine in maintaining long-term remission in one such patient with Hashimoto encephalopathy and the presence of lactate peak in magnetic resonance spectroscopy of the patient, which showed dramatic regression with institution of immunosuppression.
authors.affiliation: Department of Medicine, Pt. B.D.S. PGIMS, Rohtak, Haryana, India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Singh
authors.forename: Sucharita
authors.initials: S
authors.lastname: Ray
authors.forename: Shalini
authors.initials: S
authors.lastname: Agarwal
authors.forename: Raj Pal
authors.initials: RP
authors.lastname: Verma
authors.forename: Paulomi
authors.initials: P
authors.lastname: Talapatra
authors.forename: Vikas
authors.initials: V
authors.lastname: Gupta
keywords: Anti-thyreoperoxidase; MRI-spectroscopy; azathioprine; encephalopathy; lactate peak; methylprednisolone