title: EEG source localization in full-term newborns with hypoxic-ischemia.
abstract: The aim of this study was to evaluate EEG source localization by standardized weighted low-resolution brain electromagnetic tomography (swLORETA) for monitoring of fullterm newborns with hypoxic-ischemic encephalopathy, using a standard anatomic head model. Three representative examples of neonatal hypoxic-ischemia were included. The method was validated with MRI data. Hypoxic-ischemic areas, visible on MRI, correlated well with swLORETA current density distributions. In addition, neonatal seizure activity may be localized. The calculated current density distributions provide easy-to-interpret localized information about neonatal brain function, which may enable detailed longitudinal monitoring and potential assessment of treatment efficacy.
authors.forename: Ward
authors.initials: W
authors.lastname: Jennekens
authors.forename: Frank
authors.initials: F
authors.lastname: Dankers
authors.forename: Paul
authors.initials: P
authors.lastname: Blijham
authors.forename: Pierre
authors.initials: P
authors.lastname: Cluitmans
authors.forename: Carola
authors.initials: C
authors.lastname: van Pul
authors.forename: Peter
authors.initials: P
authors.lastname: Andriessen
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000503:physiopathology; D014054:Tomography / Q000379:methods*