title: Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA.
abstract: PFC serum concentrations were measured in 6-8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12-19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens.
authors.affiliation: University of Cincinnati College of Medicine, Department of Environmental Health, PO Box 670056, Cincinnati, OH 45267-0056, USA. Electronic address: susan.pinney@uc.edu.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Pinney
authors.forename: Frank M
authors.initials: FM
authors.lastname: Biro
authors.forename: Gayle C
authors.initials: GC
authors.lastname: Windham
authors.forename: Robert L
authors.initials: RL
authors.lastname: Herrick
authors.forename: Lusine
authors.initials: L
authors.lastname: Yaghjyan
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Paul
authors.initials: P
authors.lastname: Succop
authors.forename: Heidi
authors.initials: H
authors.lastname: Sucharew
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Ball
authors.forename: Kayoko
authors.initials: K
authors.lastname: Kato
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Kushi
authors.forename: Robert
authors.initials: R
authors.lastname: Bornschein
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D060766:Drinking Water / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000097:blood*; D004787:Environmental Pollution / Q000706:statistics & numerical data; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D012495:San Francisco; D018508:Water Purification; D014881:Water Supply / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D004785:Environmental Pollutants; D005466:Fluorocarbons
keywords: Biomonitoring; Children; Drinking water contaminants; Human milk; Polyfluoroalkyl compounds (PFCs)