title: Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.
abstract: Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes.
authors.affiliation: Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Frame
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: McGrath
authors.forename: James
authors.initials: J
authors.lastname: Palis
mesh_terms: D000818:Animals; D019070:Cell Lineage; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D023461:Myeloid Progenitor Cells / Q000166:cytology* / Q000502:physiology*
keywords: AGM; BFU-E; E; EMP; ESC; Embryogenesis; Erythro-myeloid progenitors; HSC; Hematopoiesis; Hpf; Yolk sac; aorta–gonad-mesonephros; burst-forming units erythroid; embryonic day; embryonic stem cell; erythro-myeloid progenitors; hematopoietic stem cell; hours post fertilization; iPSC; induced pluripotent stem cell