title: Monitoring of neuromuscular blockade in one muscle group alone may not reflect recovery of total muscle function in patients with ocular myasthenia gravis.
abstract: OBJECTIVE
  We report on two patients with ocular myasthenia gravis who received rocuronium, followed later by sugammadex to reverse neuromuscular blockade. Recovery was monitored simultaneously at the adductor pollicis muscle (APM) and the corrugator supercilii muscle (CSM).
  
  
  METHODS
  Two patients with ocular myasthenia gravis (case 1: 74 yr-old female, 54 kg; case 2: 71 yr-old male, 72 kg) were scheduled for surgery under general anesthesia. Neuromuscular blockade was induced with rocuronium 0.3 mg·kg(-1) after placing two separate monitors at the APM and the CSM, respectively. Additional doses of rocuronium 0.1-0.2 mg·kg(-1) were given to maintain neuromuscular blockade at fewer than two twitches at the APM during surgery. Train-of-four response at the CSM did not show recovery of the twitch after its initial disappearance. At the end of surgery, sugammadex was administered. Twitch height at the APM recovered to the control value in 12 min (case 1) and 13 min (case 2) after sugammadex administration; however, twitch height at the CSM took 26 min (case 1) and 14 min (case 2) to recover to the control value.
  
  
  CONCLUSIONS
  After rocuronium-induced paralysis in both patients with ocular myasthenia, spontaneous recovery and sugammadex-assisted recovery were slower at the CSM than at the APM. In patients without the disorder, CSM recovery is faster than APM recovery. Thus, in ocular myasthenia gravis, neuromuscular recovery at the APM may not reflect recovery of all muscles.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takahoko
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Otomo
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sasakawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kunisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D000732:Androstanols / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009157:Myasthenia Gravis / Q000503:physiopathology*; D019148:Neuromuscular Blockade; D020127:Recovery of Function; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology
chemical_list: D000732:Androstanols; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium