title: Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models.
abstract: The benzopyran and dihydrobenzopyran moieties can be considered as "privileged motifs" in drug discovery being good platforms for the search of new bioactive compounds. These moieties are commonly found fused to the xanthonic scaffold belonging to the biologically important family of the generally designated prenylated xanthones. Several pyranoxanthones have shown promising antitumor activity and since most of them are from natural origin, the biosynthetic pathway only allows a particular pattern of substitution which limits their structural diversity and renders any broad structure-activity study hard to be established. Accordingly, with the aim of rationalizing the importance of the fused ring orientation and oxygenation pattern in pyranoxanthones, this study describes the synthesis of 14 new pyranoxanthones and evaluation of their cell growth inhibitory activity in four human tumor cell lines as well as their lipophilicity in two membrane models. This systematic approach allowed establishing structure-activity and structure-lipophilicity relationships for the obtained compounds in combination with 6 previously described compounds. From this work an angular pyranoxanthone scaffold emerged as particularly promising, presenting a potent cell growth inhibitory activity and suitable drug-like lipophilicity.
authors.affiliation: Centro de Química Medicinal da Universidade do Porto (CEQUIMED-UP), Rua de Jorge Viterbo Ferreira n.° 228, 4050-313 Porto, Portugal; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
authors.forename: Carlos M G
authors.initials: CM
authors.lastname: Azevedo
authors.forename: Carlos M M
authors.initials: CM
authors.lastname: Afonso
authors.forename: José X
authors.initials: JX
authors.lastname: Soares
authors.forename: Salette
authors.initials: S
authors.lastname: Reis
authors.forename: Diana
authors.initials: D
authors.lastname: Sousa
authors.forename: Raquel T
authors.initials: RT
authors.lastname: Lima
authors.forename: M Helena
authors.initials: MH
authors.lastname: Vasconcelos
authors.forename: Madalena
authors.initials: M
authors.lastname: Pedro
authors.forename: João
authors.initials: J
authors.lastname: Barbosa
authors.forename: Luís
authors.initials: L
authors.lastname: Gales
authors.forename: Madalena M M
authors.initials: MM
authors.lastname: Pinto
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D061986:MCF-7 Cells; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D008823:Micelles; D044004:Xanthones
keywords: AGPBWIJOTOAIJF-UHFFFAOYSA-N; Antitumor; Benzopyran; Chromans; Chromene; DFUSNNVZHPWEQA-UHFFFAOYSA-N; DGWZGTZFARNTOX-UHFFFAOYSA-N; GEHOOMUECVMABY-UHFFFAOYSA-N; GIFMZEFTVVYDLL-UHFFFAOYSA-N; GQQNCIBKGHDXHZ-UHFFFAOYSA-N; IEBFTSIPXMVBOB-UHFFFAOYSA-N; ITRAHUAVOADDFX-UHFFFAOYSA-N; IXSPMALLMDABPI-UHFFFAOYSA-N; JCSVHRWWVSXXLL-UHFFFAOYSA-N; JWUMCGRKTXMGHE-UHFFFAOYSA-N; MLFQPQKMYSPJGK-UHFFFAOYSA-N; NIYOFKHNJSNYPA-UHFFFAOYSA-N; NRKPZEHCYCBLQJ-UHFFFAOYSA-N; OHVCQKKAZZAQRP-UHFFFAOYSA-N; PDMOSLIHIMBXHC-UHFFFAOYSA-N; UBFPJRWNHVZZEC-UHFFFAOYSA-N; WJVAAIKKVCXFJE-UHFFFAOYSA-N; WWEMWFCLNGFTGG-UHFFFAOYSA-N; XTIBCIHWCDQZJY-UHFFFAOYSA-N; Xanthen-9-ones; Xanthones; YNALSCCSNBOXHB-UHFFFAOYSA-N