title: [Blood pressure lowering efficacy of telmisartan and amlodipine taking on the morning or at bedtime: ABPM results].
abstract: OBJECTIVE
  To observe the blood lowering effect of telmisartan and amlodipine taking on the morning or at bedtime in hypertensive patients.
  
  
  METHODS
  A total of 108 individuals with hypertension (grade 2 or above) were randomized to receive telmisartan and amlodipine in one of the following four therapeutic schemes: Group A (26 cases): both medications taken on the morning; Group B (28 cases): both medication taken at bedtime; Group C (27 cases): telmisartan on the morning and amlodipine at bedtime; or Group D (27 cases): amlodipine on the morning and telmisartan at bedtime. ABPM was performed before and after 8 weeks treatment.
  
  
  RESULTS
  BP was significantly reduced in 4 groups and the value of 24 hours SBP/DBP decline for each group after treatment was 29.94/16.32, 31.37/18.35, 29.49/17.30 and 25.80/15.51 mm Hg (1 mm Hg = 0.133 kPa) respectively (P < 0.05 vs. baseline). SI (smooth index) of 24 hours SBP/DBP was 1.79/1.34, 2.07/1.54, 1.70/1.43 and 1.55/1.32 respectively (P > 0.05). The night-time BP decline and the distributive difference of dipper, non-dipper, extreme dipper and reverse dipper pattern were similar among groups at both baseline and after various treatment regimens (all P > 0.05) . Morning blood pressure surge (MBPS) after treatment in group B declined more significantly than other groups (P < 0.05).
  
  
  CONCLUSIONS
  Telmisartan/amlodipine administered either on the morning or at bedtime can effectively reduce blood pressure. The efficacy of BP lowering is independent of the drug taking time. There is a trend both in better BP lowering and less BP variability when two medications are administered at bedtime.
authors.affiliation: Department of Cardiology, Hengli Hospital of Dongguan, Dongguan 523460, China (Email: hlyypgc@163.com).
authors.forename: Gui-cheng
authors.initials: GC
authors.lastname: Peng
authors.forename: Yi-fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Xiao
authors.forename: Jian-fu
authors.initials: JF
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu-liang
authors.initials: YL
authors.lastname: Ye
authors.forename: Shuang-qiao
authors.initials: SQ
authors.lastname: Sai
authors.forename: Jin-xiang
authors.initials: JX
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D001565:Benzoates / Q000008:administration & dosage*; D018660:Blood Pressure Monitoring, Ambulatory; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000077333:Telmisartan
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D017311:Amlodipine; D000077333:Telmisartan