title: Impact of caffeic acid phenethyl ester treatment on vancomycin-induced pancreatic damage in rats.
abstract: This study investigates the preventive effect of caffeic acid phenethyl ester (CAPE) on pancreatic damage induced by vancomycin (VCM) in rats. Rats were equally divided into three groups: group I (control), group II (only VCM-treated group) and group III (VCM + CAPE-treated groups). VCM was intraperitoneally administered at a dose of 200 mg kg(-1)twice daily for 7 days. CAPE was administered orally at 10 µM mL(-1) kg(-1) dose once daily for 7 days. The first dose of CAPE administration was performed 24 h prior to VCM injection. Blood and pancreas tissue samples were removed and collected after the study. Serum alkaline phosphatase (ALP), amylase, γ-glutamyl transferase (GGT) and lipase activities were determined. Pancreas tissue samples were evaluated with the light microscope. Group II significantly increased serum ALP, amylase, GGT and lipase activities when compared with the control group. Group III significantly decreased serum ALP, amylase, GGT and lipase activities when compared with group II. In histopathological examination, it has been observed that there was a significant pancreatic damage in group II. CAPE exerted prominent structural protection against VCM-induced pancreatic damage and this effect was statistically significant. CAPE caused a marked reduction in the extent of pancreatic damage. We have concluded that it may play an important role in the VCM-induced pancreatic damage and reduce the pancreatic damage both at the biochemical and histopathological aspects.
authors.affiliation: Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey ahmetkoyu@yahoo.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Koyu
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Gokalp
authors.affiliation: Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Gumral
authors.affiliation: Department of Pediatric Nephrology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Oktem
authors.affiliation: Department of Medical Pathology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Nermin
authors.initials: N
authors.lastname: Karahan
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Mugla Sitki Kocman University, Isparta, Turkey.
authors.forename: Nigar
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Saygin
mesh_terms: D000208:Acute Disease; D000469:Alkaline Phosphatase / Q000097:blood; D000681:Amylases / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology*; D008049:Lipase / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D014640:Vancomycin; D005723:gamma-Glutamyltransferase; D008049:Lipase; D000469:Alkaline Phosphatase; D000681:Amylases; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol
keywords: Vancomycin; amylase; caffeic acid phenethyl ester; lipase; pancreatic histopathology