title: Ceftaroline fosamil and treatment of acute bacterial skin and skin structure infections: CAPTURE study experience.
abstract: The Clinical Assessment Program and TEFLARO Utilization Registry (CAPTURE) is a multicentre retrospective cohort study in the USA describing treatment of acute bacterial skin and skin structure infection (ABSSSI) with ceftaroline fosamil (CPT-F). Charts for review were chosen by random selection. Among 647 evaluable patients, 52% were obese, 46% had diabetes mellitus (DM), and 19% had peripheral vascular disease (PVD). Methicillin-resistant Staphylococcus aureus (MRSA) was recovered in 28% and methicillin-susceptible S. aureus (MSSA), 11%. Antibiotics were administered prior to CPT-F treatment in 80%, and concurrently in 39%. Clinical success overall was 85%; in patients with DM, 83%; with PVD, 76%; and in obese patients, 88%. Clinical success was ≥ 79% across all infection types; 81% for MRSA and 83% for MSSA; and 86% for ceftaroline monotherapy and 84% for concurrent therapy. These high clinical success rates support CPT-F as an effective treatment option for ABSSSI, including infections due to MRSA and patients with significant co-morbidities.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Santos
authors.forename: Amanda
authors.initials: A
authors.lastname: Davis
authors.forename: Alena
authors.initials: A
authors.lastname: Jandourek
authors.forename: Alexander
authors.initials: A
authors.lastname: Smith
authors.forename: H
authors.initials: H
authors.lastname: David Friedland
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy; D055815:Young Adult; D000097583:Ceftaroline
chemical_list: D002511:Cephalosporins; D000097583:Ceftaroline
keywords: ABSSSI,; Acute bacterial skin and skin structure infection,; CAPTURE,; Diabetes mellitus,; MRSA,; Obesity; Peripheral vascular disease,; ceftaroline fosamil,