title: Current management decisions in mild cognitive impairment.
abstract: Efforts toward early detection of Alzheimer disease (AD) have focused on refinement and identification of diagnostic markers, with the goal of preventing or delaying disease progression. Mild cognitive impairment (MCI) has emerged as a potential precursor to dementia. Though not without controversy, MCI has been associated with an increased risk for conversion to AD. In this article, with emphasis on meta-analyses, randomized controlled trials, and extant literature reviews, considerations and recommendations for optimal clinical management of MCI are offered. Given the substantial heterogeneity of this patient population and inconsistent research methodologies, the need for informed, clinical judgment is critical.
authors.affiliation: Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, ORB 1200, Oklahoma City, OK 73117, USA. Electronic address: Benjamin.bensadon@gmail.com.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Bensadon
authors.forename: Germaine L
authors.initials: GL
authors.lastname: Odenheimer
mesh_terms: D000368:Aged; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D060825:Cognitive Dysfunction / Q000209:etiology / Q000523:psychology / Q000628:therapy*; D015438:Health Behavior; D006801:Humans; D011613:Psychotherapy; D012648:Self Care
chemical_list: D002800:Cholinesterase Inhibitors
keywords: Cognition; Dementia; Impairment; MCI; Memory