title: Regional cerebral blood flow in children from 3 to 5 months of age.
abstract: OBJECTIVE
  Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children.
  
  
  METHODS
  Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere.
  
  
  RESULTS
  There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001).
  
  
  CONCLUSIONS
  These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children.
authors.affiliation: From the Department of Pediatrics, Division of Neonatology (A.F.D., J.L.).
authors.forename: A F
authors.initials: AF
authors.lastname: Duncan
authors.forename: A
authors.initials: A
authors.lastname: Caprihan
authors.forename: E Q
authors.initials: EQ
authors.lastname: Montague
authors.forename: J
authors.initials: J
authors.lastname: Lowe
authors.forename: R
authors.initials: R
authors.lastname: Schrader
authors.forename: J P
authors.initials: JP
authors.lastname: Phillips
mesh_terms: D000367:Age Factors; D001931:Brain Mapping; D002560:Cerebrovascular Circulation; D054022:Cerebrum / Q000098:blood supply*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013113:Spin Labels
chemical_list: D013113:Spin Labels