title: Black dog barks at brown fat.
abstract: CRY2 genetic variants associate with the depressive episodes in a range of mood disorders. Expression of core clock genes is highly responsive to stimuli in brown fat. Brown fat clocks might synchronize clocks in other tissues through their control of heat production and core body temperature. Among the repressors within the clocks, CRY2 is hypothesized to a key to the resetting of clocks throughout and play a leading role in the antidepressant effect of total sleep deprivation.
authors.affiliation: National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services , Helsinki , Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Partonen
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001831:Body Temperature; D056926:CLOCK Proteins / Q000235:genetics; D056931:Cryptochromes / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics*; D005786:Gene Expression Regulation; D014644:Genetic Variation; D006801:Humans; D019964:Mood Disorders / Q000235:genetics*; D012892:Sleep Deprivation / Q000378:metabolism
chemical_list: C538966:CRY2 protein, human; D056931:Cryptochromes; D056926:CLOCK Proteins