title: Genome-wide association and sequencing studies on colorectal cancer.
abstract: Colorectal cancer is a leading cause of morbidity and mortality worldwide. Understanding its genetic mechanisms is key to improving risk prediction, prognostication and treatment. Results from genome-wide association studies have engendered a growing list of colorectal cancer susceptibility genes whereas the application of genome-wide mutational analysis has enabled the depiction of mutational landscape of colorectal cancer at high resolution. The development of novel technologies, such as metagenomic and single-cell sequencing, is expected to have positive impact on future genetic studies. However, challenges remain to address the changing epidemiology of colorectal cancer, issues on genetic testing, and clinical utilization of genomic data.
authors.affiliation: Institute of Digestive Disease and State Key Laboratory of Digestive Disease, Department of Medicine & Therapeutics and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Sunny H
authors.initials: SH
authors.lastname: Wong
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: Francis K L
authors.initials: FK
authors.lastname: Chan
authors.forename: Ka F
authors.initials: KF
authors.lastname: To
authors.forename: Simon S M
authors.initials: SS
authors.lastname: Ng
authors.forename: Xiao J
authors.initials: XJ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: William K K
authors.initials: WK
authors.lastname: Wu
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009154:Mutation; D015398:Signal Transduction
keywords: Colorectal cancer; GWAS; Mutation; Next-generation sequencing