title: Glycopeptide vaccine on DNA-histone carrier and its impact on Z-potential of effector cells during experimental treatment of lymphoblastic leukemia.
abstract: OBJECTIVE
  To increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC).
  
  
  METHODS
  The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats. Glycopeptide cancer vaccine prepared from P-388 leukemia cells, was immobilized of RC. ζ-potential of thymocytes from tumor-bearing mice was calculated from Smoluchowski equation.
  
  
  RESULTS
  The data have demonstrated the principal possibility of using the fragments of reconstructed chromatin of heterologous origin as a carrier of glycopeptide cancer vaccine prepared from the cells of P-388 leukemia. Preventive immunization with the correspondingly immobilized vaccine normalized ζ-potential of thymocytes in animals with transplanted P‑388 leukemia.
  
  
  CONCLUSIONS
  The use of immobilization of glycopeptide cancer vaccine on reconstructed chromatin improves anticancer activity of the vaccination.
authors.affiliation: RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Janisch
authors.forename: A B
authors.initials: AB
authors.lastname: Artamonova
authors.forename: V A
authors.initials: VA
authors.lastname: Shlyakhovenko
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000737:chemistry / Q000494:pharmacology*; D002843:Chromatin / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D051381:Rats
chemical_list: D019496:Cancer Vaccines; D002843:Chromatin