title: Chromosome 9p21 primary open-angle glaucoma susceptibility locus: a review.
abstract: Primary open-angle glaucoma (POAG) is a genetically complex disease. Genome-wide association study (GWAS) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome-wide association studies suggesting associations to POAG. Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG.
authors.affiliation: South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia; University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Soo Khai
authors.initials: SK
authors.lastname: Ng
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Casson
authors.forename: Kathryn P
authors.initials: KP
authors.lastname: Burdon
authors.forename: Jamie E
authors.initials: JE
authors.lastname: Craig
mesh_terms: D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure; D062085:RNA, Long Noncoding / Q000235:genetics; D012307:Risk Factors
chemical_list: C561518:CDKN2B antisense RNA, human; C493966:CDKN2B protein, human; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D062085:RNA, Long Noncoding
keywords: 9p21; CDKN2A; CDKN2B; CDKN2B-AS1.