title: Complex metabolically demanding sensory processing in the olfactory system: implications for epilepsy.
abstract: Although the olfactory system is not generally associated with seizures, sharp application of odor eliciting activity in a large number of olfactory sensory neurons (OSNs) has been shown to elicit seizures. This is most likely due to increased ictal activity in the anterior piriform cortex-an area of the olfactory system that has limited GABAergic interneuron inhibition of pyramidal output cell activity. Such hyperexcitability in a well-characterized and highly accessible system makes olfaction a potentially powerful model system to examine epileptogenesis.
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: diego.restrepo@ucdenver.edu.
authors.forename: Diego
authors.initials: D
authors.lastname: Restrepo
authors.affiliation: Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hellier
authors.affiliation: Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Salcedo
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000378:metabolism / Q000503:physiopathology*; D059330:GABAergic Neurons / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism / Q000503:physiopathology*; D055696:Olfactory Perception / Q000502:physiology*; D066195:Piriform Cortex / Q000378:metabolism / Q000503:physiopathology*
keywords: Epilepsy; Olfaction; Olfactory bulb; Piriform