title: Significance of INHBA expression in human colorectal cancer.
abstract: Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA expression or after exogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P<0.001). Patients in the high expression group showed a poorer overall survival rate when compared to those in the low expression group (P<0.001); the present study did not evaluate for an independent prognostic factor but showed the significance of lymph node metastasis as an independent prognostic factor. The present study suggests that INHBA is useful as a predictive marker for prognosis in CRC patients.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Okano
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hisataka
authors.initials: H
authors.lastname: Ohkuma
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kano
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kim
authors.forename: Shimpei
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Konno
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Haraguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takemasa
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Mizushima
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yokobori
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D028322:Inhibin-beta Subunits / Q000096:biosynthesis / Q000235:genetics*; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C103008:inhibin beta A subunit; D028322:Inhibin-beta Subunits