title: Multiple system atrophy.
abstract: Multiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, and cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification.
authors.affiliation: Division of Clinical Neurobiology, Department of Neurology, Medical University, Innsbruck, Austria. Electronic address: gregor.wenning@i-med.ac.at.
authors.forename: Gregor K
authors.initials: GK
authors.lastname: Wenning
authors.forename: Florian
authors.initials: F
authors.lastname: Krismer
mesh_terms: D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D019578:Multiple System Atrophy / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy
keywords: Multiple system atrophy; autonomic failure; cerebellar ataxia; orthostatic hypotension; parkinsonism; therapy; urogenital failure