title: Comparison of the effects of desflurane and sevoflurane on middle ear pressure: a randomized controlled clinical trial.
abstract: OBJECTIVE
  The aim of the present study was to compare the effects of two inhalation anesthetics, desflurane and sevoflurane, on middle ear pressure.
  
  
  METHODS
  After we obtained written consent from the patients and the approval from our institutional ethical committee, we included 56 ASA I-II patients aged between 18 and 60 years in this study. They were randomly divided into two groups of 28 patients each. Desflurane 4-6% (Group D) or sevoflurane 1-2% (Group S) were used for anesthesia management in patients. Baseline tympanometry was carried out and recorded before the induction of anesthesia on both ears, and 3 more measurements were done and recorded 5, 15 and 30 min after induction.
  
  
  RESULTS
  In both groups, middle ear pressure values were found to be significantly elevated when compared to baseline measurements (p < 0.05). When middle ear pressure was compared between the groups, no difference was found between the values obtained at baseline and at 5 min in Group S, while especially the values obtained at 15 min revealed significantly higher middle ear pressures in Group D.
  
  
  CONCLUSIONS
  It was observed that the increase in middle ear pressure caused by sevoflurane was significantly lower than that caused by desflurane.
authors.affiliation: Department of Anesthesiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Cevdet
authors.initials: C
authors.lastname: Duger
authors.forename: Mansur
authors.initials: M
authors.lastname: Dogan
authors.forename: Ahmet Cemil
authors.initials: AC
authors.lastname: Isbir
authors.forename: Iclal
authors.initials: I
authors.lastname: Ozdemir Kol
authors.forename: Sinan
authors.initials: S
authors.lastname: Gursoy
authors.forename: Kenan
authors.initials: K
authors.lastname: Kaygusuz
authors.forename: Omer Fatih
authors.initials: OF
authors.lastname: Sahin
authors.forename: Ismail Onder
authors.initials: IO
authors.lastname: Uysal
authors.forename: Caner
authors.initials: C
authors.lastname: Mimaroglu
mesh_terms: D000158:Acoustic Impedance Tests; D000293:Adolescent; D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000077335:Desflurane; D004432:Ear, Middle / Q000187:drug effects* / Q000601:surgery*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D013506:Otologic Surgical Procedures; D011312:Pressure; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane