title: [A case of calcineurin-inhibitor induced pain syndrome associated with tacrolimus therapy for ulcerative colitis].
abstract: A 23-year-old woman was admitted with a relapse of ulcerative colitis. Tacrolimus therapy was initiated following inadequate response to corticosteroid therapy. Although the symptoms partially improved, she suddenly developed severe pain localized to the lower limbs on day 16 of tacrolimus therapy. By day 17, she was unable to move. Magnetic resonance imaging revealed born marrow edema in the lower limbs. We suspected calcineurin-inhibitor induced pain syndrome (CIPS) due to tacrolimus therapy. The pain improved within approximately four weeks of tacrolimus cessation. CIPS that is not associated with organ transplantation is a rare occurrence. Here we report a rare case of CIPS that was caused by tacrolimus therapy in a patient with ulcerative colitis.
authors.affiliation: Department of Gastroenterology, Sendai Medical Center.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tadano
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kaori
authors.initials: K
authors.lastname: Sugawara
authors.forename: Mikako
authors.initials: M
authors.lastname: Sugimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iwabuchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Mano
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Ukai
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tadokoro
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Mori
mesh_terms: D065095:Calcineurin Inhibitors; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010146:Pain / Q000139:chemically induced*; D013577:Syndrome; D016559:Tacrolimus / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D065095:Calcineurin Inhibitors; D016559:Tacrolimus