title: Acute functional decline before hospitalization in older patients.
abstract: OBJECTIVE
  Acute diseases and related hospitalization are crucial events in the disabling process of elderly individuals. Most of the functional decline occurs in the few days before hospitalization, as a result of acute diseases in vulnerable patients. The aim of the present study was to identify determinants of prehospital components of functional decline.
  
  
  METHODS
  This was a prospective observational study carried out in three acute geriatric units and two general medicine units of three Italian hospitals. The participants were 1281 patients aged 65 years or older admitted to hospital for acute illnesses and discharged alive. Functional status 2 weeks before hospitalization (preadmission) and at hospital admission was measured by the Barthel Index to identify patients with prehospital decline. In this group of decliners, the percentage extent of prehospital decline (PEPD) was also calculated.
  
  
  RESULTS
  Prehospital decline occurred in 541 (42.2%) patients, who were hospitalized mostly in geriatric wards (55.6%). Older age (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.04-1.08) and dementia (OR 2.8, 95% CI 1.4-5.4) were significant predictors of prehospital decline, whereas a high preadmission function was protective (OR 0.992, 95% CI 0.987-0.997). Pulmonary disease as primary discharge diagnosis was also associated with prehospital decline (OR 1.8, 95% CI 1.3-2.5) after adjustment for age, diagnosis of dementia and preadmission function. Amongst decliners, a low preadmission function and the origin of patients (from emergency rooms or other hospital units) were associated with larger PEPD.
  
  
  CONCLUSIONS
  Using a clinically meaningful change to define decline, disease-related prehospital disability is observed mainly in persons with low preadmission function, older age and dementia.
authors.affiliation: Unit of Geriatrics, Azienda Ospedaliera S. Giovanni-Addolorata, Rome, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Palleschi
authors.forename: Filippo Luca
authors.initials: FL
authors.lastname: Fimognari
authors.forename: Andrea
authors.initials: A
authors.lastname: Pierantozzi
authors.forename: Bernardo
authors.initials: B
authors.lastname: Salani
authors.forename: Alberto
authors.initials: A
authors.lastname: Marsilii
authors.forename: Stefano Maria
authors.initials: SM
authors.lastname: Zuccaro
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Cioccio
authors.forename: Walter
authors.initials: W
authors.lastname: De Alfieri
mesh_terms: D000203:Activities of Daily Living; D000208:Acute Disease / Q000453:epidemiology / Q000628:therapy*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D016330:Frail Elderly / Q000706:statistics & numerical data*; D015577:Geriatric Assessment / Q000379:methods*; D006760:Hospitalization; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors
keywords: acute diseases; functional decline; hospitalization