title: Development of a patient specific artificial tracheal prosthesis: design, mechanical behavior analysis and manufacturing.
abstract: There is a need to create patient specific organ replacements as there are differences in the anatomical dimensions among individuals. High failure rates in tracheal prosthesis are attributed to the lack of mechanical strength and flexibility, slow rate of growth of ciliated epithelium and leakage of interstitial fluid into the lumen. This paper proposes a methodology of design, simulations and fabrication of a patient specific artificial tracheal prosthesis for implantation to closely mimic the biomechanical properties of the natural trachea, and describes the prototype device and its materials. Results show that the patient-specific trachea prosthesis has mechanical properties approximate that of normal tracheal rings. The user centric tracheal prosthesis is demonstrated to be a promising candidate for tracheal replacement.
authors.forename: Matthew
authors.initials: M
authors.lastname: Chua C H
authors.forename: Chee Kong
authors.initials: CK
authors.lastname: Chui
authors.forename: Bina
authors.initials: B
authors.lastname: Rai
authors.forename: David
authors.initials: D
authors.lastname: Lau D P
mesh_terms: D002356:Cartilage / Q000502:physiology; D003198:Computer Simulation; D017076:Computer-Aided Design; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D006801:Humans; D055595:Mechanical Phenomena; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013314:Stress, Mechanical; D014132:Trachea / Q000502:physiology*
chemical_list: D004129:Dimethylpolysiloxanes