title: In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria.
abstract: In vitro activity of ozenoxacin, a novel nonfluorinated topical (L. D. Saravolatz and J. Leggett, Clin. Infect. Dis. 37:1210-1215, 2003) quinolone, was compared with the activities of other quinolones against well-characterized quinolone-susceptible and quinolone-resistant Gram-positive bacteria. Ozenoxacin was 3-fold to 321-fold more active than other quinolones. Ozenoxacin could represent a first-in-class nonfluorinated quinolone for the topical treatment of a broad range of dermatological infections.
authors.affiliation: Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: López
authors.forename: M
authors.initials: M
authors.lastname: Tato
authors.forename: P
authors.initials: P
authors.lastname: Espinal
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Alonso
authors.forename: D
authors.initials: D
authors.lastname: Gargallo-Viola
authors.forename: R
authors.initials: R
authors.lastname: Cantón
authors.forename: J
authors.initials: J
authors.lastname: Vila
mesh_terms: D000631:Aminopyridines / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000737:chemistry / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000631:Aminopyridines; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; C000592413:ozenoxacin