title: The specific characteristics of DIC syndrome vary with different clinical settings in the newborn.
abstract: Abstract Two hundred fourteen newborns with serious perinatal pathology (posthypoxic syndrome, sepsis, surgical intervention, etc.) were examined in progress, according to 27 parameters including coagulative, trombocitic, anti-coagulative and fibrinolitic parts of hemostasis system. It was proved, that neonatal disseminated intravascular coagulation (DIC) syndrome had different hemostasiological patterns, which were connected with the genesis: sepsis, surgical intervention or posthypoxic syndrome. Precise periods of DIC syndrome are not always presented in newborns. DIC syndrome with neonatal sepsis has two different patterns (overcompensated and decompensated). The manifestation of trombo-hemorrhagic disorders and their characteristics depend on the genesis of DIC syndrome (e.g. an infection process and hyperbilirubinemia can provide the appearance of hemorrhagic syndrome).
authors.affiliation: Federal Center of Blood, Heart and Endocrinology by V.A. Almazov , St-Petersburg , Russia and.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Ivanov
authors.forename: Nicolai
authors.initials: N
authors.lastname: Shabalov
authors.forename: Yiri
authors.initials: Y
authors.lastname: Petrenko
authors.forename: Nina
authors.initials: N
authors.lastname: Shabalova
authors.forename: N A
authors.initials: NA
authors.lastname: Treskina
mesh_terms: D004065:Digestive System Abnormalities / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000151:congenital* / Q000175:diagnosis* / Q000503:physiopathology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000503:physiopathology; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery; D011014:Pneumonia / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000503:physiopathology; D018805:Sepsis / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000503:physiopathology; D012720:Severity of Illness Index; D013577:Syndrome
keywords: DIC syndrome; SIRS (systemic inflammatory response syndrome); hemostasis; newborns; posthypoxic