title: A case of cutaneous angiolipoleiomyoma (angiomyolipoma) in a budgerigar (Melopsittacus undulatus).
abstract: We report a case of cutaneous angiolipoleiomyoma (angiomyolipoma) found on the anterior wall of the ventral part of the abdomen of a three-year-old female budgerigar (Melopsittacus undulatus). Histologic examination of the well-circumscribed, surgically removed tumour (1.5 cm in diameter) showed a benign admixed proliferation of blood vessels of different size, smooth muscle bundles, and mature adipose tissue, without evidence of malignancy. Endothelial cells of the haemangioma component were positive for claudin-5 endothelium-specific immunohistochemical marker, and the leiomyoma component was positive for α-smooth muscle actin. The differentiated lipocytes showed S-100 protein positivity. The Ki-67 labelling index was 2 to 3%. The mesenchymal tumour was negative for HMB45 melanocytic immunhistochemical marker. To the best of our knowledge, this is the first report describing a cutaneous angiolipoleiomyoma in a budgerigar with histological and immunohistochemical analyses.
authors.affiliation: a Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science , Szent István University , Budapest , Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Jakab
authors.forename: Gyula
authors.initials: G
authors.lastname: Balka
authors.forename: Agnes
authors.initials: A
authors.lastname: Szabára
authors.forename: Csintalan
authors.initials: C
authors.lastname: Csaba
authors.forename: Péter
authors.initials: P
authors.lastname: Pazár
mesh_terms: D000199:Actins / Q000378:metabolism; D018207:Angiomyolipoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001715:Bird Diseases / Q000473:pathology* / Q000601:surgery*; D062507:Claudin-5 / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D046408:Melopsittacus; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D000199:Actins; D015415:Biomarkers; D062507:Claudin-5