title: Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats.
abstract: BACKGROUND
  Hericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Diabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in blood, and oxidative stress parameters in the liver were evaluated. The body weights of rats were recorded at day 0, 14 and 28th days.
  
  
  RESULTS
  The administration of AEHE for 28 days in STZ diabetic rats resulted in a significant decrease in serum glucose level and a significant rise in serum insulin level. AEHE treatment attenuated lipid disorders. In addition, AEHE administration increased the activities of CAT, SOD, and GSH-Px, and GSH level, and reduced MDA level in the liver tissue significantly.
  
  
  CONCLUSIONS
  Our results suggest that AEHE possesses hypoglycemic, hypolipidemic, and antioxidant properties in STZ-induced diabetes rats.
authors.affiliation: Department of Clinical Laboratory, High Vocational Technological College, China Medical University, North Bei'er Road, No, 92, Shenyang 110001, Liaoning, PR China. liangtechb1@yahoo.com.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Guo
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Ainong
authors.initials: A
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol