title: Structure-revealing data fusion model with applications in metabolomics.
abstract: In many disciplines, data from multiple sources are acquired and jointly analyzed for enhanced knowledge discovery. For instance, in metabolomics, different analytical techniques are used to measure biological fluids in order to identify the chemicals related to certain diseases. It is widely-known that, some of these analytical methods, e.g., LC-MS (Liquid Chromatography - Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) spectroscopy, provide complementary data sets and their joint analysis may enable us to capture a larger proportion of the complete metabolome belonging to a specific biological system. Fusing data from multiple sources has proved useful in many fields including bioinformatics, signal processing and social network analysis. However, identification of common (shared) and individual (unshared) structures across multiple data sets remains a major challenge in data fusion studies. With a goal of addressing this challenge, we propose a novel unsupervised data fusion model. Our contributions are two-fold: (i) We formulate a data fusion model based on joint factorization of matrices and higher-order tensors, which can automatically reveal common and individual components. (ii) We demonstrate that the proposed approach provides promising results in joint analysis of metabolomics data sets consisting of fluorescence and NMR measurements of plasma samples in terms of separation of colorectal cancer patients from controls.
authors.forename: Evrim
authors.initials: E
authors.lastname: Acar
authors.forename: Anders J
authors.initials: AJ
authors.lastname: Lawaetz
authors.forename: Morten A
authors.initials: MA
authors.lastname: Rasmussen
authors.forename: Rasmus
authors.initials: R
authors.lastname: Bro
mesh_terms: D000465:Algorithms; D002853:Chromatography, Liquid; D015179:Colorectal Neoplasms / Q000097:blood* / Q000378:metabolism*; D019295:Computational Biology; D003198:Computer Simulation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055442:Metabolome; D055432:Metabolomics; D008962:Models, Theoretical; D012815:Signal Processing, Computer-Assisted