title: Tracking stem cells in tissue-engineered organs using magnetic nanoparticles.
abstract: The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and track SCs by magnetic resonance imaging (MRI) since this clinically available imaging modality has high spatial resolution. In this review, we highlight recent applications of iron oxide and gadolinium based MNPs in SC labelling and MRI; and offer novel considerations for their future development.
authors.affiliation: Department of Physics & Astronomy, University College London, Gower Street, London WC1E 6BT, UK. roxanne.hachani.12@ucl.ac.uk ntk.thanh@ucl.ac.uk.
authors.forename: Roxanne
authors.initials: R
authors.lastname: Hachani
authors.forename: Mark
authors.initials: M
authors.lastname: Lowdell
authors.forename: Martin
authors.initials: M
authors.lastname: Birchall
authors.forename: Nguyen Thi Kim
authors.initials: NT
authors.lastname: Thanh
mesh_terms: D058948:Cell Tracking; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D023822:Tissue Engineering
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011956:Receptors, Cell Surface; C000499:ferric oxide; D005682:Gadolinium