title: Development of nonstick and drug-loaded wound dressing based on the hydrolytic hydrophobic poly(carboxybetaine) ester analogue.
abstract: A novel biocompatible polymer is developed for antimicrobial and nonstick coatings of wound dressing. The polymer is formed by copolymerization of carboxybetaine ester analogue methacrylate (CB-ester) and small partial poly(ethylene glycol) methacrylate (PEGMA) for cross-linking by hexamethylene diisocyanate (HDI), which is highly resistant to nonspecific protein adsorption and mammalian cell attachment after a quick hydrolysis. A small hydrophobic drug, aspirin, can be incorporated into the new polymer and slowly released to inhibit microorganism growth while the new polymer shows very low cytotoxicity. Moreover, the wound dressing, the new polymer coated medical gauze, shows good mechanic properties, such as flexibility and strength, for medical application. After all, this new nonfouling polymer offers great potential for an antimicrobial wound dressing and other applications.
authors.affiliation: State Key Laboratory of Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University , Hangzhou 310027, P. R. China.
authors.forename: Fangqin
authors.initials: F
authors.lastname: Ji
authors.forename: Weifeng
authors.initials: W
authors.lastname: Lin
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Longgang
authors.initials: L
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Guanglong
authors.initials: G
authors.lastname: Ma
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry* / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000627:therapeutic use; D013499:Surface Properties; D058106:Wound Closure Techniques; D014945:Wound Healing
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D008689:Methacrylates; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols