title: Consumption of wheat bran modified by autoclaving reduces fat mass in hamsters.
abstract: OBJECTIVE
  To investigate the effect that wheat bran modified by autoclaving (MWB) had on reducing fat accumulation in hamsters fed a hypercholesterolemia- and obesity-inducing diet.
  
  
  METHODS
  Male hamsters (n = 45) were randomized into 3 groups and fed a hypercholesterolemia- and obesity-inducing diet with or without 10% standard wheat bran or MWB for 28 days. Our outcome measures included body composition measured by DXA, oxygen consumption and plasma lipids and glucose concentrations.
  
  
  RESULTS
  Animals fed the MWB diet had lower % fat mass (49.8 vs. 53.4%; p = 0.02) and higher % lean body mass (47.2 vs. 44.1%; p = 0.02) compared with controls despite no differences in food intake or weight gain. Additionally, plasma glucose tended to be lower (6.9 vs. 8.5 mmol/l; p < 0.08) in the MWB animals compared with controls.
  
  
  CONCLUSIONS
  Our data suggest that the compositional changes in autoclaved wheat bran, specifically solubility of phenolic antioxidants and fiber, may have contributed to the lower fat accumulation in our animals. Further study is needed to determine whether the exact mechanism involved increased lipolysis and energy utilization from adipose.
authors.affiliation: Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada, scott.harding@kcl.ac.uk.
authors.forename: Scott V
authors.initials: SV
authors.lastname: Harding
authors.forename: Harry D
authors.initials: HD
authors.lastname: Sapirstein
authors.forename: Todd C
authors.initials: TC
authors.lastname: Rideout
authors.forename: Christopher P F
authors.initials: CP
authors.lastname: Marinangeli
authors.forename: Arshala K M
authors.initials: AK
authors.lastname: Dona
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Jones
mesh_terms: D050154:Adiposity; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000627:therapeutic use*; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000627:therapeutic use; D002170:Canada; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D004043:Dietary Fiber / Q000032:analysis / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000032:analysis; D005511:Food Handling; D016166:Free Radical Scavengers / Q000737:chemistry / Q000627:therapeutic use; D006358:Hot Temperature; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D008647:Mesocricetus; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011897:Random Allocation; D012639:Seeds / Q000737:chemistry*; D012995:Solubility; D014908:Triticum / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D016166:Free Radical Scavengers