title: Genetic characterization of CCL3, CCL4 and CCL5 in leporid genera Oryctolagus, Sylvilagus and Lepus.
abstract: The genetic diversity of C-C motif chemokine receptor 5 (CCR5) ligands CCL3, CCL4 and CCL5 in the leporid genera Oryctolagus, Sylvilagus and Lepus was studied. Our results demonstrate that the three CCR5 chemokine ligands are under strong purifying selection as a result of possible functional binding constraints.
authors.affiliation: CIBIO - Centro de Investigação em Biodiversidade e Recursos Genéticos/InBio Laboratório Associado, Universidade do Porto, Vairão, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Porto, Portugal; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
authors.forename: A Lemos
authors.initials: AL
authors.lastname: de Matos
authors.forename: D K
authors.initials: DK
authors.lastname: Lanning
authors.forename: P J
authors.initials: PJ
authors.lastname: Esteves
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D054405:Chemokine CCL3 / Q000235:genetics*; D054407:Chemokine CCL4 / Q000235:genetics*; D018946:Chemokine CCL5 / Q000235:genetics*; D014644:Genetic Variation; D034621:Hares / Q000235:genetics* / Q000276:immunology; D008024:Ligands; D008969:Molecular Sequence Data; D011817:Rabbits
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D008024:Ligands