title: Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin.
abstract: An 82-year-old woman with type 2 diabetes mellitus, hypertension, and unstable angina presented with severe lactic acidosis and acute kidney injury (AKI) accompanied by acute pancreatitis. Her medical history revealed that she had taken cimetidine for two weeks while taking other medications, including metformin. Continuous veno-venous hemodiafiltration (CVVHDF) was initiated under diagnosis of lactic acidosis due to metformin and AKI caused by cimetidine-induced acute pancreatitis. In three days of CVVHDF, the levels of serum biochemical markers of lactic acidosis and AKI improved and the patient's urine output reached over 1 L/day. The pancreatitis improved over time.
authors.affiliation: Department of Internal Medicine, Catholic University of Daegu School of Medicine, Korea.
authors.forename: Ji Ho
authors.initials: JH
authors.lastname: Seo
authors.forename: Da Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Hong
authors.forename: In Hee
authors.initials: IH
authors.lastname: Lee
authors.forename: Ki Sung
authors.initials: KS
authors.lastname: Ahn
authors.forename: Gun Woo
authors.initials: GW
authors.lastname: Kang
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D000369:Aged, 80 and over; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004347:Drug Interactions / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D007004:Hypoglycemic Agents; D002927:Cimetidine; D008687:Metformin