title: A CMOS enhanced solid-state nanopore based single molecule detection platform.
abstract: Solid-state nanopores have emerged as a single molecule label-free electronic detection platform. Existing transimpedance stages used to measure ionic current nanopores suffer from dynamic range limitations resulting from steady-state baseline currents. We propose a digitally-assisted baseline cancellation CMOS platform that circumvents this issue. Since baseline cancellation is a form of auto-zeroing, the 1/f noise of the system is also reduced. Our proposed design can tolerate a steady state baseline current of 10µA and has a usable bandwidth of 750kHz. Quantitative DNA translocation experiments on 5kbp DNA was performed using a 5nm silicon nitride pore using both the CMOS platform and a commercial system. Comparison of event-count histograms show that the CMOS platform clearly outperforms the commercial system, allowing for unambiguous interpretation of the data.
authors.forename: Chinhsuan
authors.initials: C
authors.lastname: Chen
authors.forename: Sukru
authors.initials: S
authors.lastname: Yemenicioglu
authors.forename: Ashfaque
authors.initials: A
authors.lastname: Uddin
authors.forename: Ellie
authors.initials: E
authors.lastname: Corgliano
authors.forename: Luke
authors.initials: L
authors.lastname: Theogarajan
mesh_terms: D000669:Amplifiers, Electronic; D003198:Computer Simulation; D004247:DNA / Q000032:analysis*; D008670:Metals / Q000737:chemistry*; D058608:Nanopores; D036103:Nanotechnology / Q000379:methods*; D010087:Oxides / Q000737:chemistry*; D012666:Semiconductors; D059629:Signal-To-Noise Ratio
chemical_list: D008670:Metals; D010087:Oxides; D004247:DNA