title: Laminin-database v.2.0: an update on laminins in health and neuromuscular disorders.
abstract: The laminin (LM)-database, hosted at http://www.lm.lncc.br, was published in the NAR database 2011 edition. It was the first database that provided comprehensive information concerning a non-collagenous family of extracellular matrix proteins, the LMs. In its first version, this database contained a large amount of information concerning LMs related to health and disease, with particular emphasis on the haemopoietic system. Users can easily access several tabs for LMs and LM-related molecules, as well as LM nomenclatures and direct links to PubMed. The LM-database version 2.0 integrates data from several publications to achieve a more comprehensive knowledge of LMs in health and disease. The novel features include the addition of two new tabs, 'Neuromuscular Disorders' and 'miRNA--LM Relationship'. More specifically, in this updated version, an expanding set of data has been displayed concerning the role of LMs in neuromuscular and neurodegenerative diseases, as well as the putative involvement of microRNAs. Given the importance of LMs in several biological processes, such as cell adhesion, proliferation, differentiation, migration and cell death, this upgraded version expands for users a panoply of information, regarding complex molecular circuitries that involve LMs in health and disease, including neuromuscular and neurodegenerative disorders.
authors.affiliation: Bioinformatics Laboratory, National Laboratory of Scientific Computation, Avenue Getúlio Vargas 333, 25651-075, Petrópolis, Rio de Janeiro, Brazil and Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Avenue Brasil 4365, 21045-900, Rio de Janeiro, Brazil.
authors.forename: Daiane C F
authors.initials: DC
authors.lastname: Golbert
authors.forename: Eliane
authors.initials: E
authors.lastname: Santana-van-Vliet
authors.forename: Alex S
authors.initials: AS
authors.lastname: Mundstein
authors.forename: Vicente
authors.initials: V
authors.lastname: Calfo
authors.forename: Wilson
authors.initials: W
authors.lastname: Savino
authors.forename: Ana Tereza R
authors.initials: AT
authors.lastname: de Vasconcelos
mesh_terms: D000818:Animals; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D007797:Laminin / Q000378:metabolism*; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000378:metabolism*; D051381:Rats
chemical_list: D007797:Laminin; D035683:MicroRNAs