title: [How safe are dimenhydrinate suppositories?].
abstract: METHODS
  A 13-month-old girl suffered from 3 generalized tonic-clonic seizures for several minutes within a total period of 9 hours. History revealed that the child received a total of 5 dimenhydrinate containing suppositories à 40 mg during the previous 2 days (i. e. 23 mg dimenhydrinate per kg body weight) due to enteritis with vomiting. The first seizure occurred 10 hours after the last administration.
  
  
  METHODS
  The plasma level of diphenhydramin was 230 µg/l approximately one hour after the first seizure. Electroencephalography showed no pathological signs, an MRI scan of the brain was normal except of several small gliotic spots and body temperature was regularly.
  
  
  METHODS
  Two stationary occurring seizures were stopped with 5 mg diazepam rectally. Continued surveillance and an EEG two days later showed age-appropriate normal findings. There were no further seizures in the next 4 years.
  
  
  CONCLUSIONS
  Infants have the risk to develop dimenhydrinate intoxication, especially in cases where suppositories were given repeatedly because of intermittent defecation.
authors.affiliation: Universitätsklinik und Poliklinik für Kinder und Jugendliche, Leipzig.
authors.forename: M K
authors.initials: MK
authors.lastname: Bernhard
authors.forename: U
authors.initials: U
authors.lastname: Mütze
authors.forename: S
authors.initials: S
authors.lastname: Syrbe
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000633:toxicity*; D004111:Dimenhydrinate / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D062787:Drug Overdose / Q000175:diagnosis*; D004569:Electroencephalography / Q000187:drug effects; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D005759:Gastroenteritis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D013488:Suppositories
chemical_list: D000932:Antiemetics; D013488:Suppositories; D004111:Dimenhydrinate