title: Detection of stress hormones by a microfluidic-integrated polycarbazole/fullerene photodetector.
abstract: A novel photodetector integrated microfluidic system for chemiluminescence (CL) detection is reported. The system incorporates a polycarbazole/fullerene photodiode whose optical characteristics (i.e. dark current, external quantum efficiency and photosensitivity) are described here. Using a CL immunoassay for detecting the stress hormone cortisol, the integrated photodetector achieved a detection sensitivity of 1.775 pA × nM(-1) and a detection limit of less than 0.28 nM. The device would be a powerful low-cost alternative to silicon photodiode and photomultiplier tube for bioanalytical assays, with potentially wide-ranging applications within point-of-care diagnostics.
authors.forename: Nuno M M
authors.initials: NM
authors.lastname: Pires
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
mesh_terms: D004867:Equipment Design; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D057230:Limit of Detection; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D012825:Silicon / Q000737:chemistry
chemical_list: D037741:Fullerenes; D006854:Hydrocortisone; D012825:Silicon