title: [The human body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls in residents' human breast milk from Beijing in 2007].
abstract: OBJECTIVE
  To investigate contamination levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human breast milk from Beijing residents, and evaluate the human body burden of PCDD/Fs and dl-PCBs of general population.
  
  
  METHODS
  A total of 110 human milk samples were collected from 11 regions in Beijing in 2007. After 11 pooled samples were made, concentrations of PCDD/Fs and dl-PCBs in breast milk pooled samples were measured by a high resolution gas chromatography - high resolution mass spectrometry (HRCG-HRMS) with isotope dilution.
  
  
  RESULTS
  For congeners of PCDD/Fs and dl-PCBs in human breast milk from Beijing, the highest content of congeners was octachlorodibenzo-p-dioxin (OCDD), polychlorinated biphenyl (PCB)-118, and PCB-105 with the median of 20.6 pg/g fat, 4.07 ng/g fat and 1.63 ng/g fat, respectively. The concentration median of total dioxins in 11 pooled human milk samples from Beijing was 7.4 pg TEQ/g fat. The highest was 13.5 pg TEQ/g fat from Tongzhou, and the lowest was 4.3 pg TEQ/g fat from Pinggu.
  
  
  CONCLUSIONS
  The contamination level of PCDD/Fs and dl-PCBs in human milk from Beijing is relatively low. However, with the rapid industrialization in China, the human body burden of PCDD/Fs and dl-PCBs will be likely to rise. Thus, further studies should be conducted to continuously monitor the trend of contamination level.
authors.affiliation: The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (China National Center of Food Safety and Risk Assessment), Beijing 100021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Yin-ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Jing-guang
authors.initials: JG
authors.lastname: Li
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Zhao
authors.forename: Yong-ning
authors.initials: YN
authors.lastname: Wu
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000032:analysis; D001822:Body Burden; D002681:China; D004147:Dioxins / Q000032:analysis*; D004785:Environmental Pollutants; D005260:Female; D006801:Humans; D018811:Maternal Exposure; D008895:Milk, Human / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000032:analysis; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis; D011108:Polymers / Q000032:analysis; D055815:Young Adult
chemical_list: D001572:Benzofurans; D004147:Dioxins; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls