title: [Research of placental vascular distribution and clinical outcome in monochorionic twins].
abstract: OBJECTIVE
  To study the placental vascular distribution of monochorionic (MC) twins with twin-to-twin transfusion syndrome (TTTS) or birth weight discordance.
  
  
  METHODS
  Twenty-eight MC placentas were injected in Peking University Third Hospital between Feb. 2010 and Feb. 2011. The vascular distribution type (parallel, crossed, mixed and monoamniotic), the anastomosis of vessels and the placental sharing were recorded. The outcome of pregnancy and the placental characteristics of birth weight discordance (birth weight discordance≥20%) in non-TTTS MC twins were analyzed.
  
  
  RESULTS
  (1) The outcome of pregnancy: the miscarriage or gestational weeks of 28 MC twins were 20 to 38 weeks (median of 35 weeks). Six cases were TTTS, 3 of which received fetoscopic laser occlusion of communicating vessels (FLOC). There were 48 live births, with an average birth weight of (2036±623) g. (2) Type of placental vascular distribution:in the 28 MC placentas, number of parallel, crossed, mixed and monoamniotic type of placental vascular distribution were 4 (14%), 14 (50%), 6 (21%) and 4 (14%) cases, respectively. No parallel type was found in TTTS. There was no significant difference of vascular anastomosis or unequal placental sharing among the different placental vascular distribution types (P>0.05). (3) Characteristics of placental vascular distribution in birth weight discordance twins:there were 20 non-TTTS MC twin pregnancies, all of which got live births of both babies. Birth weight discordance equal to or more than 20% was found in 6 pairs of newborns, while birth weight discordance less than 20% was found in the rest 14 cases. Ratio of unequal placental sharing was significantly different between the two groups (P<0.01). There was no significant difference of umbilical cord insertion, placental vascular distribution and anastomosis in the two groups (P>0.01).
  
  
  CONCLUSIONS
  Vascular distribution type of MC twins might be related to TTTS. Unequal placental sharing is a risk factor of birth weight discordance in non-TTTS MC twins.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shao
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Peng-bo
authors.initials: PB
authors.lastname: Yuan
authors.forename: Xiao-yue
authors.initials: XY
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yang-yu
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D001163:Arteriovenous Anastomosis / Q000473:pathology; D001724:Birth Weight; D002823:Chorion / Q000098:blood supply / Q000473:pathology; D005260:Female; D005330:Fetofetal Transfusion / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D005332:Fetoscopy; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D010920:Placenta / Q000098:blood supply* / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D014430:Twins, Monozygotic; D014470:Umbilical Cord / Q000473:pathology