title: [Impact of baseline pulse pressure on new-onset cardio-and cerebrovascular events in diabetic population].
abstract: OBJECTIVE
  To observe the association between baseline pulse pressure (PP) level and new-onset cardio-cerebrovascular events in diabetic population.
  
  
  METHODS
  Physical examination data between July 2006 to October 2007 from a total of 101 510 employees of Kailuan Group were reviewed, 8306 subjects with a fasting plasma glucose level of ≥ 7.0 mmol/L or with confirmed diabetes diagnosis and were enrolled in this prospective cohort study. Subjects were followed up for 38-53 (48.1 ± 3.1) months and the cardio-cerebrovascular events were obtained every six months, association between baseline PP and new-onset cardio-cerebrovascular events in the diabetic population were analyzed.
  
  
  RESULTS
  (1) Incidences of total cardio-cerebrovascular events in the PP groups were 3.4%, 2.8%, 4.5%, 6.4%, respectively. Incidences of cerebral infarction events and myocardial infarction were 2.1%, 1.6%, 2.9%, 3.9% and 1.1%, 0.7%, 1.0%, 1.7%, respectively. (2) Multivariate Cox's proportional hazards regression analysis indicated that baseline PP group was the risk factor for total cardio-cerebrovascular events, cerebral infarction events and myocardial infarction, and the risk for all the events of the PP ≥ 60 mm Hg (1 mm Hg = 0.133 kPa) group was increasing. The values of RR(95%CI) were 1.88 (95%CI 1.34-2.65, P < 0.01), 1.92 (95%CI 1.23-2.99, P < 0.01) and 1.52 (95%CI 0.82-2.81, P > 0.05) after adjust the other factors.(3) In line with increasing level of baseline PP, age, BMI, SBP, DBP, HDL-C, and hs-CRP levels significantly increased in this diabetic population (P < 0.01 or P < 0.05).
  
  
  CONCLUSIONS
  The level of high baseline PP is a risk factor for new-onset cardio-cerebrovascular events in diabetic population.
authors.affiliation: Department of Physical examination, Affiliated Kailuan Hospital, Hebei United University, Tangshan 063000, China.
authors.forename: Xiu-rong
authors.initials: XR
authors.lastname: Liu
authors.forename: Shou-ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Li-ye
authors.initials: LY
authors.lastname: Wang
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Su
authors.forename: Zheng-xin
authors.initials: ZX
authors.lastname: Cao
authors.forename: Yan-ru
authors.initials: YR
authors.lastname: Zhou
authors.forename: Ya-hui
authors.initials: YH
authors.lastname: Sun
authors.forename: Yue-qiu
authors.initials: YQ
authors.lastname: Sun
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult