title: The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments.
abstract: In this prospective cohort of women undergoing infertility treatments, we measured specific-gravity adjusted urinary BPA (SG-BPA) concentrations and used regression models to evaluate the association of BPA with antral follicle count (AFC), day-3 serum follicle stimulating hormone levels (FSH), and ovarian volume (OV). BPA, detected in >80% of women, had a geometric mean (±GSD) of 1.6±2.0, 1.7±2.1, and 1.5±1.8μg/L for the women contributing to the AFC (n=154), day-3 FSH (n=120), and OV (n=114) analyses, respectively. There was an average decrease in AFC of 12% (95% CI: -23%, -0.6%), 22% (95% CI: -31%, -11%), and 17% (95% CI: -27%, -6%), in the 2nd, 3rd, and 4th SG-BPA quartile compared to the 1st quartile, respectively (p-trend: <0.001). No association of SG-BPA with FSH or OV was observed. Among women from an infertility clinic, higher urinary BPA concentrations were associated with lower AFC, raising concern for possible accelerated follicle loss and reproductive aging.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School/Massachusetts General Hospital Fertility Center, Yawkey 10-A, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: isouter@partners.org.
authors.forename: Irene
authors.initials: I
authors.lastname: Souter
authors.forename: Kristen W
authors.initials: KW
authors.lastname: Smith
authors.forename: Irene
authors.initials: I
authors.lastname: Dimitriadis
authors.forename: Shelley
authors.initials: S
authors.lastname: Ehrlich
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D052244:Endocrine Disruptors / Q000652:urine*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000188:drug therapy / Q000652:urine; D008875:Middle Aged; D009929:Organ Size; D006080:Ovarian Follicle / Q000166:cytology*; D010053:Ovary / Q000033:anatomy & histology; D010636:Phenols / Q000652:urine*; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D005640:Follicle Stimulating Hormone; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: AFC; AMH; Antral follicle count; BPA; Bisphenol-A; Day-3 follicle stimulating hormone; EDC; FSH; HSPH; Harvard School of Public Health; LOD; MGH; Massachusetts General Hospital; OV; Ovarian reserve; Ovarian volume; SG; anti-mullerian hormone; antral follicle count; bisphenol-A; endocrine disrupting compounds; follicle stimulating hormone; limit of detection; ovarian volume; specific gravity