title: Modeling intrinsic electrophysiology of AII amacrine cells: preliminary results.
abstract: In patients who have lost their photoreceptors due to retinal degenerative diseases, it is possible to restore rudimentary vision by electrically stimulating surviving neurons. AII amacrine cells, which reside in the inner plexiform layer, split the signal from rod bipolar cells into ON and OFF cone pathways. As a result, it is of interest to develop a computational model to aid in the understanding of how these cells respond to the electrical stimulation delivered by a prosthetic implant. The aim of this work is to develop and constrain parameters in a single-compartment model of an AII amacrine cell using data from whole-cell patch clamp recordings. This model will be used to explore responses of AII amacrine cells to electrical stimulation. Single-compartment Hodgkin-Huxley-type neural models are simulated in the NEURON environment. Simulations showed successful reproduction of the potassium currentvoltage relationship and some of the spiking properties observed in vitro.
authors.forename: Nick
authors.initials: N
authors.lastname: Apollo
authors.forename: David B
authors.initials: DB
authors.lastname: Grayden
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Burkitt
authors.forename: Hamish
authors.initials: H
authors.lastname: Meffin
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kameneva
mesh_terms: D025042:Amacrine Cells / Q000166:cytology* / Q000502:physiology*; D003198:Computer Simulation; D004558:Electric Stimulation; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D007477:Ions; D008268:Macular Degeneration / Q000503:physiopathology; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000737:chemistry; D012160:Retina / Q000502:physiology*; D012164:Retinal Diseases / Q000503:physiopathology*; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology; D012174:Retinitis Pigmentosa / Q000503:physiopathology; D012964:Sodium / Q000737:chemistry; D012984:Software; D013779:Tetrodotoxin / Q000737:chemistry
chemical_list: D007477:Ions; D013779:Tetrodotoxin; D012964:Sodium; D011188:Potassium