title: Attenuation of cardiovascular responses and upper airway events to tracheal extubation by low dose propofol.
abstract: BACKGROUND
  Hemodynamic changes and respiratory tract complications are often followed by tracheal extubation. These events may be dangerous in neurosurgical patients and those with cardiovascular disease or at an old age.
  
  
  OBJECTIVE
  The aim of this study is to investigate the attenuation of cardiovascular responses and upper airway events resulting from tracheal extubation by low dose propofol.
  
  
  METHODS
  80 patients with ASA physical status I, undergoing an elective surgery in a double blind manner received 0.5mg/kg propofol or normal saline 2 minutes before extubation. Heart rate and blood pressure and quality of tracheal extubation were recorded.
  
  
  RESULTS
  Heart rate and blood pressure in patients receiving propofol were less than the control group (P < 0.05) at the time of injection of propofol, but there were no differences between the two groups at the time of extubation.
  
  
  CONCLUSIONS
  We concluded that propofol can reduce SBP, DBP, MAP, HR & cough production at the time of injection but there were no significant changes in these parameters after extubation.
authors.affiliation: Department of Anesthesiology, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.
authors.forename: Mohammad Taghy
authors.initials: MT
authors.lastname: Moein Vaziri
authors.forename: Reza
authors.initials: R
authors.lastname: Jouybar
authors.forename: Nader
authors.initials: N
authors.lastname: Moein Vaziri
authors.forename: Najmeh
authors.initials: N
authors.lastname: Moein Vaziri
authors.forename: Ashkan
authors.initials: A
authors.lastname: Panah
keywords: Airway Extubation; Hemodynamics; Propofol; Respiratory System