title: Relationship between visual acuity and spectral domain optical coherence tomography retinal parameters in neovascular age-related macular degeneration.
abstract: OBJECTIVE
  Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD).
  
  
  METHODS
  VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA.
  
  
  RESULTS
  At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina (R = -0.7, p < 0.001), outer nuclear layer (R = -0.6, p < 0.05) and PRL (R = -0.7, p < 0.001). Decrease in VA after 1 year correlated with a decrease in PRL (R = 0.4, p < 0.05).
  
  
  CONCLUSIONS
  Quantitative analysis of SD-OCT revealed correlations between VA and retinal and subretinal morphological changes in NVAMD.
  
  
  CONCLUSIONS
  Atrophy of the outer retina is an important correlate for lower VA in NVAMD.
authors.affiliation: Cologne Image Reading Center, Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
authors.forename: Tina
authors.initials: T
authors.lastname: Ristau
authors.forename: Pearse A
authors.initials: PA
authors.lastname: Keane
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Walsh
authors.forename: Alicia
authors.initials: A
authors.lastname: Engin
authors.forename: Nils
authors.initials: N
authors.lastname: Mokwa
authors.forename: Bernd
authors.initials: B
authors.lastname: Kirchhof
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
authors.forename: Sandra
authors.initials: S
authors.lastname: Liakopoulos
mesh_terms: D000368:Aged; D001284:Atrophy; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D008269:Macular Edema / Q000503:physiopathology*; D008297:Male; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D057135:Wet Macular Degeneration / Q000503:physiopathology*