title: Anti-oxLDL antibodies are clinically insignificant for stroke patients.
abstract: OBJECTIVE
  The question about anti-oxidized low-density lipoprotein antibodies (anti-oxLDL Abs) involvement in the pathogenesis of atherosclerosis-related ischemic stroke is still open. The aim of this study was to determine how anti-oxLDL Abs are involved in the pathogenesis of atherosclerosis-related ischemic stroke and identify the main risk factors for stroke, such as arterial hypertension, diabetes mellitus type 2, dyslipidemia, and atherosclerotic changes in the common and internal carotid arteries.
  
  
  METHODS
  A total of 40 stroke patients and 25 age- and sex-matched healthy individuals were included in the study. For each subject, IgG anti-oxLDL Abs expression in peripheral blood was assessed and analyzed in relation to clinical data, carotid Doppler ultrasonography results, and results of peripheral blood laboratory tests, including inflammatory parameters and lipid profile.
  
  
  RESULTS
  The blood level of assessed antibodies was significantly higher in stroke patients than in control group. It did not relate to stroke severity and stroke outcome. The relationship between anti-oxLDL Abs and carotid plaques hyperechogenicity was observed. The antibodies concentration was significantly higher in patients with diabetes mellitus type 2 and also positively correlated with C-reactive protein blood level. However, multiple regression method did not confirm their independent influence.
  
  
  CONCLUSIONS
  Patients with atherogenic ischemic stroke may have significantly higher anti-oxLDL Abs concentrations. This should be interpreted as an attempt to limit the consequences of oxLDL production; however, this phenomenon does not seem to protect patients against cerebrovascular events.
authors.forename: Marta
authors.initials: M
authors.lastname: Masztalewicz
authors.forename: Przemysław
authors.initials: P
authors.lastname: Nowacki
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kotlęga
authors.forename: Anna
authors.initials: A
authors.lastname: Bajer-Czajkowska
authors.forename: Hanna
authors.initials: H
authors.lastname: Drechsler
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000000981:diagnostic imaging / Q000276:immunology; D018608:Ultrasonography, Doppler
chemical_list: D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein
keywords: Anti-oxLDL antibodies,; Carotid atherosclerosis,; Stroke