title: Antigen modulation confers protection to red blood cells from antibody through Fcγ receptor ligation.
abstract: Autoantibodies and alloantibodies can damage self-tissue or transplanted tissues through either fixation of complement or ligation of FcγRs. Several pathways have been described that imbue self-tissues with resistance to damage from complement fixation, as a protective measure against damage from these Abs. However, it has been unclear whether parallel pathways exist to provide protection from FcγR ligation by bound Abs. In this article, we describe a novel pathway by which cell surface Ag is specifically decreased as a result of Ab binding (Ag modulation) to the extent of conferring protection to recognized cells from Fcγ-dependent clearance. Moreover, the Ag modulation in this system requires FcγR ligation. Together, these findings provide unique evidence of self-protective pathways for FcγR-mediated Ab damage.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322;
authors.forename: Sean R
authors.initials: SR
authors.lastname: Stowell
authors.forename: Justine S
authors.initials: JS
authors.lastname: Liepkalns
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Hendrickson
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Girard-Pierce
authors.forename: Nicole H
authors.initials: NH
authors.lastname: Smith
authors.forename: C Maridith
authors.initials: CM
authors.lastname: Arthur
authors.forename: James C
authors.initials: JC
authors.lastname: Zimring
mesh_terms: D000818:Animals; D016525:Antigenic Modulation / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017452:Receptors, IgG / Q000276:immunology* / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D001323:Autoantibodies; D007074:Immunoglobulin G; D007518:Isoantibodies; D017452:Receptors, IgG; D003165:Complement System Proteins