title: Blind source separation in characterizing ECG pre-shock waveforms during Ventricular Fibrillation.
abstract: Ventricular Fibrillation (VF) is a cardiac arrhythmia for which the only available treatment option is defibrillation by electrical shock. Existing literature indicates that VF could be the manifestation of different sources controlling the heart with different degrees of organization. In this work we test the hypothesis that the pre-shock waveforms of successful and unsuccessful shock outcomes could be related to the number of independent sources present in these waveforms. The proposed method uses Blind Source Separation (BSS) to extract independent components in frequency direction from a pig database consisting of 20 pre-shock waveforms. The slope of the energy capture curve was used as an indicator to demonstrate the number of independent sources required to model the pre-shock waveforms. The results were also quantified by performing a linear discriminant analysis based classification achieving an overall classification accuracy of 75%. The results indicate that successful cases can be modeled with less number of independent sources compared to unsuccessful cases.
authors.forename: M
authors.initials: M
authors.lastname: Rasooli
authors.forename: F H
authors.initials: FH
authors.lastname: Foomany
authors.forename: K
authors.initials: K
authors.lastname: Balasundaram
authors.forename: S
authors.initials: S
authors.lastname: Masse
authors.forename: N
authors.initials: N
authors.lastname: Zamiri
authors.forename: A
authors.initials: A
authors.lastname: Ramadeen
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: P
authors.initials: P
authors.lastname: Dorian
authors.forename: K
authors.initials: K
authors.lastname: Nanthakumar
authors.forename: S
authors.initials: S
authors.lastname: Beheshti
authors.forename: K
authors.initials: K
authors.lastname: Umapathy
mesh_terms: D000465:Algorithms; D000818:Animals; D004554:Electric Countershock; D004562:Electrocardiography; D012815:Signal Processing, Computer-Assisted; D034421:Sus scrofa; D014463:Ultrasonography; D014693:Ventricular Fibrillation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D058067:Wavelet Analysis