title: Cell division: control of the chromosomal passenger complex in time and space.
abstract: The ultimate goal of cell division is equal transmission of the duplicated genome to two new daughter cells. Multiple surveillance systems exist that monitor proper execution of the cell division program and as such ensure stability of our genome. One widely studied protein complex essential for proper chromosome segregation and execution of cytoplasmic division (cytokinesis) is the chromosomal passenger complex (CPC). This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis. Not surprisingly, it also performs various functions during these phases of the cell cycle. In this review, we will give an overview of the latest insights into the regulation of CPC localization and discuss if and how specific localization impacts its diverse functions in the dividing cell.
authors.affiliation: Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, STR 2.131, 3584, CG, Utrecht, The Netherlands.
authors.forename: Armando
authors.initials: A
authors.lastname: van der Horst
authors.forename: Susanne M A
authors.initials: SM
authors.lastname: Lens
mesh_terms: D000818:Animals; D002455:Cell Division; D002503:Centromere / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism*; D025461:Feedback, Physiological; D006801:Humans; D008941:Spindle Apparatus / Q000378:metabolism; D013997:Time Factors