title: Drugs to cure avian influenza infection--multiple ways to prevent cell death.
abstract: New treatments and new drugs for avian influenza virus (AIV) infection are developed continually, but there are still high mortality rates. The main reason may be that not all cell death pathways induced by AIV were blocked by the current therapies. In this review, drugs for AIV and associated acute respiratory distress syndrome (ARDS) are summarized. The roles of antioxidant (vitamin C) and multiple immunomodulators (such as Celecoxib, Mesalazine and Eritoran) are discussed. The clinical care of ARDS may result in ischemia reperfusion injury to poorly ventilated alveolar cells. Cyclosporin A should effectively inhibit this kind of damages and, therefore, may be the key drug for the survival of patients with virus-induced ARDS. Treatment with protease inhibitor Ulinastatin could also protect lysosome integrity after the infection. Through these analyses, a large drug combination is proposed, which may hypothetically greatly reduce the mortality rate.
authors.affiliation: College of Resources and Environmental Sciences, Sichuan Agricultural University, Chengdu, China.
authors.forename: S
authors.initials: S
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001717:Birds / Q000821:virology; D016923:Cell Death / Q000187:drug effects; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D009980:Influenza A virus / Q000187:drug effects / Q000502:physiology*; D005585:Influenza in Birds / Q000188:drug therapy* / Q000473:pathology* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D007155:Immunologic Factors