title: Cytokine Induced Killer (CIK) cells for the treatment of haematological neoplasms.
abstract: Cytokine Induced Killer (CIK) cells are in vitro activated human CD8 T cells which have maintained several characteristics of T-EMRA cells and additionally acquired non specific anti tumoral cytotoxicity and CD56 overexpression, thus representing a cell population with double T and NK phenotype. Due to their in vivo intratumoral homing and lack of Graft versus Host (GVH) reactivity, CIK cells have been extensively used in cancer patients either in autologous or allogeneic contexts. Here we summarise CIK main biological features as well as their most prominent clinical results.
authors.affiliation: Laboratorio di Terapia Cellulare "G. Lanzani", USC Ematologia, Ospedale Papa Giovanni XXIII, Bergamo, Italy. Electronic address: mintrona@hpg23.it.
authors.forename: M
authors.initials: M
authors.lastname: Introna
authors.forename: J
authors.initials: J
authors.lastname: Golay
authors.forename: A
authors.initials: A
authors.lastname: Rambaldi
mesh_terms: D000818:Animals; D019002:CD56 Antigen / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology* / Q000637:transplantation; D007694:Killer Cells, Natural / Q000276:immunology*
chemical_list: D019002:CD56 Antigen; D016207:Cytokines
keywords: Cytokine Induced Killer (CIK) cells; Haematologic neoplasms; Hematopoietic stem cells transplantation