title: Long-term renal outcomes of consecutive patients undergoing open type IV thoracoabdominal aneurysm repair.
abstract: OBJECTIVE
  To evaluate long-term renal outcomes after open type IV thoracoabdominal aneurysm (TAAA) repair.
  
  
  METHODS
  Retrospective analysis of a prospectively collected database of consecutive operated non-ruptured type IV TAAAs (2007-2011).
  
  
  METHODS
  Renal function was analysed by serum creatinine concentration, estimated glomerular filtration rate (eGFR) and Kidney Disease Outcomes Quality Initiative (KDOQI) stage. The primary outcome was the change in creatinine concentration from before surgery to defined time points after surgery: peak postoperative; discharge; at follow-up (>1 year postoperatively). Secondary outcomes were change in eGFR, change in KDOQI stage, dialysis requirement, and 30-day mortality.
  
  
  RESULTS
  Between 2007 and 2011, 53 open type IV TAAA repairs were performed. Median creatinine levels significantly increased in the immediate postoperative period, but returned to baseline by discharge. Thirteen patients (28.2%) had an improvement in follow-up eGFR of at least 20% compared with pre-operative eGFR or improved by one KDOQI stage. Twelve patients (26.1%) had a decline in eGFR of at least 20% or one KDOQI stage at follow-up. Three patients (7.5%) required temporary dialysis and one patient (1.9%) required permanent dialysis. The 30-day mortality was 1.9%.
  
  
  CONCLUSIONS
  This study demonstrates acceptable renal outcomes following open type IV TAAA repair. Open type IV repair remains the standard against which newer techniques should be compared.
authors.affiliation: Vascular Surgical Service, Royal Infirmary of Edinburgh, Edinburgh, UK.
authors.forename: N T
authors.initials: NT
authors.lastname: Ventham
authors.forename: N
authors.initials: N
authors.lastname: Johns
authors.forename: A F
authors.initials: AF
authors.lastname: Nimmo
authors.forename: C
authors.initials: C
authors.lastname: Moores
authors.forename: P J
authors.initials: PJ
authors.lastname: Burns
authors.forename: R T A
authors.initials: RT
authors.lastname: Chalmers
mesh_terms: D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000145:classification / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011859:Radiography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging; D006435:Renal Dialysis / Q000706:statistics & numerical data; D051437:Renal Insufficiency / Q000145:classification / Q000209:etiology* / Q000628:therapy; D012189:Retrospective Studies
chemical_list: D003404:Creatinine
keywords: Abdominal aneurysm; Creatinine; Glomerular filtration rate; Kidney diseases; Renal function; Thoracic aneurysm; Thoracoabdominal; Type IV