title: Variation in antibiotic susceptibility of uropathogens by age among ambulatory pediatric patients.
abstract: We compared uropathogen antibiotic susceptibility across age groups of ambulatory pediatric patients. For Escherichia coli (n=5,099) and other Gram-negative rods (n=626), significant differences (p<0.05) existed across age groups for ampicillin, cefazolin, and trimethoprim/sulfamethoxazole susceptibility. In E. coli, differences in trimethoprim/sulfamethoxazole susceptibility varied from 79% in children under 2 to 88% in ages 16-18 (p<0.001), while ampicillin susceptibility varied from 30% in children under 2 to 53% in ages 2-5 (p=0.015). Uropathogen susceptibility to common urinary anti-infectives may be lower in the youngest children. Further investigation into these differences is needed to facilitate appropriate and prudent treatment of urinary tract infections.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Oregon State University/Oregon Health & Science University, Portland, OR. Electronic address: mcgregoj@ohsu.edu.
authors.forename: Jessina C
authors.initials: JC
authors.lastname: McGregor
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Oregon State University/Oregon Health & Science University, Portland, OR.
authors.forename: Yennie
authors.initials: Y
authors.lastname: Quach
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, Oregon State University/Oregon Health & Science University, Portland, OR.
authors.forename: David T
authors.initials: DT
authors.lastname: Bearden
authors.affiliation: Center for Health Research, Kaiser Permanente Northwest, Portland, OR.
authors.forename: David H
authors.initials: DH
authors.lastname: Smith
authors.affiliation: Department of Pathology, Clinical Microbiology Laboratory, Regional Laboratory, Kaiser Permanente Northwest, Portland, OR.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Sharp
authors.affiliation: Department of Pediatrics, Oregon Health & Science University, CDRCP, Portland, OR.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Guzman-Cottrill
mesh_terms: D000293:Adolescent; D000553:Ambulatory Care; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology*; D056689:Uropathogenic Escherichia coli / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002437:Cefazolin
keywords: Ambulatory care; Antibiotic resistance; Urinary tract infection