title: Autonomic dysfunction in Parkinson disease.
abstract: In Parkinson disease (PD), symptoms and signs of autonomic failure occur commonly, especially in cardiovascular, gastrointestinal, and genitourinary domains. Most patients with PD have neuroimaging evidence of cardiac sympathetic denervation. In PD, orthostatic hypertension (OH) can be an early finding and is associated with extracardiac noradrenergic denervation and reduced baroreflex-cardiovagal and sympathoneural responses. Recognition of autonomic impairment is important because symptomatic treatment is frequently effective.
authors.affiliation: Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, NY, USA. Electronic address: Horacio.Kaufmann@nyumc.org.
authors.forename: Horacio
authors.initials: H
authors.lastname: Kaufmann
authors.forename: David S
authors.initials: DS
authors.lastname: Goldstein
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D006801:Humans; D059906:Neuroimaging; D010300:Parkinson Disease / Q000150:complications*
keywords: Parkinson disease; autonomic; baroreflex; bladder dysfunction; erectile failure; orthostatic hypotension; sweating; sympathetic nervous system