title: Trifluoromethide as a strong base: [CF3-] mediates dichloromethylation of nitrones by proton abstraction from the solvent.
abstract: An unprecedented reactivity of CF3-TMS has been revealed, which exploits the basic character of the generated [CF3(-)] capable of delivering dichloromethide from dichloromethane with subsequent transfer to nitrones under smooth conditions. The proton-abstraction pathway was demonstrated through isotopic labeling experiments in CD2Cl2. The same reaction was achieved in acetonitrile with the introduction of a cyanomethyl group onto the nitrones.
authors.affiliation: Université de Reims Champagne-Ardenne , Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, UFR Sciences Exactes et Naturelles, 51687 Reims Cedex 2, France.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Behr
authors.forename: Dani
authors.initials: D
authors.lastname: Chavaria
authors.forename: Richard
authors.initials: R
authors.lastname: Plantier-Royon