title: Evolution of definitions and understanding of vascular complications related to transcatheter aortic valve replacement.
abstract: Vascular complications have emerged as a major clinical challenge during transcatheter aortic valve replacement (TAVR). Recent reports demonstrate that major vascular complications not only predict major bleeding, transfusions, and renal failure, but are also associated with increased mortality. During the early development of TAVR, heterogeneous definitions of vascular complications were used in the literature. However, the Valve Academic Research Consortium has made significant progress in standardizing outcomes definitions in the study of this emerging technology. This has resulted in a rapidly expanding body of high-quality clinical research exploring important outcomes of TAVR, including vascular complications. This review seeks to summarize the literature and to explore the current state of knowledge with respect to the incidence, predictors, clinical impact, and management of vascular complications associated with TAVR.
authors.affiliation: Columbia University Medical Center New York-Presbyterian Hospital, Heart Valve CenterNew-York, NY, USA - jp3153@cunc.columbia.edu.
authors.forename: J M
authors.initials: JM
authors.lastname: Paradis
authors.forename: T
authors.initials: T
authors.lastname: Nazif
authors.forename: I
authors.initials: I
authors.lastname: George
authors.forename: M
authors.initials: M
authors.lastname: Leon
authors.forename: S
authors.initials: S
authors.lastname: Kodali
authors.forename: M
authors.initials: M
authors.lastname: Williams
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000473:pathology / Q000601:surgery; D001803:Blood Transfusion; D006328:Cardiac Catheterization / Q000379:methods; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D051437:Renal Insufficiency / Q000453:epidemiology / Q000209:etiology; D014652:Vascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology