title: [The safety of early laparoscopic cholecystectomy (<48 hours) for patients with mild gallstone pancreatitis: a systematic review of the literature and meta-analysis].
abstract: BACKGROUND
  In mild gallstone pancreatitis, cholecystectomy decreases the risk of recurrence. This should be performed during the initial hospitalization, but even when this is performed, the hospital stay can be prolonged, with an increase in costs and morbidity. The aim of this study is to compare the complication rate between patients who underwent an early cholecystectomy (<48 hours) vs. a late one (>48 hours).
  
  
  METHODS
  A systematic search was performed in the following data bases: PubMed, EMBASE, LILACS and Scielo. Articles on patients with acute, mild gallstone pancreatitis who required a cholecystectomy during their initial hospitalization were included and compared with those undergoing a late cholecystectomy, in order to evaluate the complications, number of days of hospitalization and need for readmission. The quality of the studies and the risks of bias were evaluated.
  
  
  RESULTS
  A total of 580 articles and summaries were identified which included 3 observational studies and a randomized clinical trial. A total of 636 patients who underwent a cholecystectomy during the initial hospitalization were included,. Ten of 207 (4.83%) in the early cholecystectomy group showed some type of complication, and 19 of 429 (4.42%) in the late cholecystectomy group, with a risk difference of -0.0016 IC 95% ([-0.04]-0.04). Three of the included studies should be considered of low quality and one of high quality. No publication bias was evidenced.
  
  
  CONCLUSIONS
  No differences in complication rate were found between patients who underwent an early cholecystectomy versus a late cholecystectomy; nevertheless, further studies should be carried out in order to confirm these findings.
authors.affiliation: Cirugía General, Fundación Universitaria de Ciencias de la Salud (FUCS)-Hospital San José, Bogotá, Colombia. Electronic address: ljrandialp@hotmail.com.
authors.forename: Leonardo José
authors.initials: LJ
authors.lastname: Randial Pérez
authors.affiliation: Cirugía General, Fundación Universitaria de Ciencias de la Salud (FUCS)-Hospital San José, Bogotá, Colombia.
authors.forename: Juan
authors.initials: J
authors.lastname: Fernando Parra
authors.affiliation: Cirugía General, Unidad de Trasplantes Hospital San José, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Aldana Dimas
mesh_terms: D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D061345:Early Medical Intervention; D042882:Gallstones / Q000150:complications* / Q000601:surgery*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D010195:Pancreatitis / Q000209:etiology* / Q000601:surgery*; D010359:Patient Readmission / Q000706:statistics & numerical data; D012720:Severity of Illness Index
keywords: Colecistectomía laparoscópica temprana; Early laparoscopic cholecystectomy; Mild gallstone pancreatitis; Pancreatitis biliar leve; Safety; Seguridad