title: H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis.
abstract: Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis.
authors.affiliation: Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea. seos@cnu.ac.kr.
authors.forename: Young Myong
authors.initials: YM
authors.lastname: Kang
authors.forename: Heui Man
authors.initials: HM
authors.lastname: Kim
authors.forename: Keun Bon
authors.initials: KB
authors.lastname: Ku
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Park
authors.forename: Jung
authors.initials: J
authors.lastname: Yum
authors.forename: Sang Heui
authors.initials: SH
authors.lastname: Seo
mesh_terms: D000818:Animals; D017209:Apoptosis; D004283:Dog Diseases / Q000235:genetics* / Q000276:immunology* / Q000635:transmission / Q000821:virology; D004285:Dogs; D005786:Gene Expression Regulation; D007249:Inflammation / Q000662:veterinary / Q000821:virology; D053122:Influenza A Virus, H3N2 Subtype / Q000472:pathogenicity* / Q000502:physiology*; D008168:Lung / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D009017:Morbidity; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary