title: Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans.
abstract: Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.
authors.affiliation: Department of Chemistry, Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, USA. yluk@syr.edu.
authors.forename: Nisha
authors.initials: N
authors.lastname: Varghese
authors.forename: Sijie
authors.initials: S
authors.lastname: Yang
authors.forename: Preeti
authors.initials: P
authors.lastname: Sejwal
authors.forename: Yan-Yeung
authors.initials: YY
authors.lastname: Luk
mesh_terms: D000268:Adhesiveness; D002176:Candida albicans / Q000737:chemistry*; D025301:Hyphae / Q000737:chemistry*; D008024:Ligands; D008353:Mannitol / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013172:Spores, Fungal / Q000737:chemistry*
chemical_list: D008024:Ligands; D010456:Peptides, Cyclic; D008353:Mannitol; D011092:Polyethylene Glycols