title: Antitumor characterization of various fractions of Launaea procumbens.
abstract: The antitumor activity of various six fractions of Launaea procumbens were studied using the potato disk bioassay technique. Three concentrations (10, 100, and 1000 ppm) of all these six fractions were used for characterization of antitumor activity. Among these fractions, methanolic fraction exhibited significant inhibition of crown gall tumors caused by Agrobacterium tumefaciens followed by butanolic fraction. These results revealed that methanolic and butanolic fractions contain bioactive constituents responsible for inhibition of tumor. Further purification and characterization are in progress in our laboratory.
authors.affiliation: Department of Biotechnology, University of Science and Technology, Bannu, Khyber Pakhtunkhwa, Pakistan Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan rahmatgul_81@yahoo.com.
authors.forename: Rahmat Ali
authors.initials: RA
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Muhammad Rashid
authors.initials: MR
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Naseer Ali
authors.initials: NA
authors.lastname: Shah
authors.affiliation: Botanical Sciences Division, Pakistan Museum of Natural History, Islamabad, Pakistan.
authors.forename: Sumaira
authors.initials: S
authors.lastname: Sahreen
authors.affiliation: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Sadaf Noor
authors.initials: SN
authors.lastname: Elahi
mesh_terms: D016960:Agrobacterium tumefaciens / Q000187:drug effects*; D019659:Asteraceae / Q000737:chemistry*; D001681:Biological Assay; D002073:Butanes / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D008697:Methane / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D010941:Plant Tumors; D011198:Solanum tuberosum / Q000187:drug effects
chemical_list: D002073:Butanes; D010936:Plant Extracts; C046888:butane; D008697:Methane
keywords: Agrobacterium tumefaciens; Launaea procumbens; crown gall tumors; potato disk bioassay