title: Poly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release.
abstract: Original core/corona nanoparticles composed of a maghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment.
authors.affiliation: Center for Education and Research on Macromolecules (CERM), University of Liège, B6a Sart-Tilman, B-4000 Liège, Belgium. christophe.detrembleur@ulg.ac.be c.jerome@ulg.ac.be.
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.forename: Christophe
authors.initials: C
authors.lastname: Detrembleur
authors.forename: Antoine
authors.initials: A
authors.lastname: Debuigne
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mornet
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Christine
authors.initials: C
authors.lastname: Labrugère
authors.forename: Etienne
authors.initials: E
authors.lastname: Duguet
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D008751:Methylene Blue / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D051379:Mice; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D005290:Ferric Compounds; D011108:Polymers; C000499:ferric oxide; C006903:carbopol 940; D011142:Polyvinyl Alcohol; D008751:Methylene Blue