title: Clinical manifestations and treatment of drug-induced hepatotoxicity.
abstract: With an increase of prescription medication and herbal supplement use, drug-induced liver injury (DILI) has become an increasingly important entity. Because DILI is a usually readily treatable condition, it is essential for providers to reach a diagnosis in a timely fashion. Unfortunately, varied clinical presentations, difficulties in establishing causality, and lack of a gold standard diagnostic criterion may make early diagnosis difficult. This article seeks to define commonly used terminology, describe common clinical presentations of DILI, provide an overview of current diagnostic criteria, and provide management guidelines.
authors.affiliation: University of Central Florida College of Medicine, 6850 Lake Nona Boulevard, Orlando, FL 32827, USA. Electronic address: cgiordano@knights.ucf.edu.
authors.forename: Christin M
authors.initials: CM
authors.lastname: Giordano
authors.forename: Xaralambos B
authors.initials: XB
authors.lastname: Zervos
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans
keywords: Drug-induced cholestasis; Drug-induced hepatocellular injury; Drug-induced liver injury; Management of drug-induced liver injury