title: Development of an informatics platform for therapeutic protein and peptide analytics.
abstract: The momentum gained by research on biologics has not been met yet with equal thrust on the informatics side. There is a noticeable lack of software for data management that empowers the bench scientists working on the development of biologic therapeutics. SARvision|Biologics is a tool to analyze data associated with biopolymers, including peptides, antibodies, and protein therapeutics programs. The program brings under a single user interface tools to filter, mine, and visualize data as well as those algorithms needed to organize sequences. As part of the data-analysis tools, we introduce two new concepts: mutation cliffs and invariant maps. Invariant maps show the variability of properties when a monomer is maintained constant in a position of the biopolymer. Mutation cliff maps draw attention to pairs of sequences where a single or limited number of point mutations elicit a large change in a property of interest. We illustrate the program and its applications using a peptide data set collected from the literature.
authors.affiliation: Altoris, Inc. , 7770 Regents Rd #557, San Diego, California 92122, United States.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Hansen
authors.forename: Hugo O
authors.initials: HO
authors.lastname: Villar
authors.forename: Eric
authors.initials: E
authors.lastname: Feyfant
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000906:Antibodies / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D054316:Biomarkers, Pharmacological; D019295:Computational Biology / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D013294:Lactococcus lactis / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D017354:Point Mutation; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D013329:Structure-Activity Relationship; D014584:User-Computer Interface
chemical_list: D000900:Anti-Bacterial Agents; D000906:Antibodies; D001688:Biological Products; D054316:Biomarkers, Pharmacological; D010455:Peptides