title: Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections.
abstract: Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations and contrasts with previous literature. The retrospective study involved 121 patients affected by OSCC who had undergone modified radical ND (MRND) for therapeutic, elective reasons or after intraoperative positivity to metastasis of sentinel lymph nodes (SLN+). Node metastasis frequency and behaviour (typical vs. atypical) and their number and distribution according to pre-surgical cTNM cancer staging were considered and overall survival Kaplan-Meier curves were calculated for each group in order to compare mortality according to ND type (elective, therapeutic, after SLN+), lymph node metastatic pattern (typical or atypical), size (micrometastasis vs. macrometastasis) and number. Results showed statistically significant different overall survival according to pre-surgical staging, number of lymph nodes harvested and intent to surgery. Sentinel lymph node resulted in the sole positive node affected by metastasis in small cT1- cT2/cN0 OSCC and an ND subsequent to its positivity during intraoperative assessment may be considered an overtreatment.
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples, I-80138 Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Contaldo
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Napoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pannone
authors.forename: Renato
authors.initials: R
authors.lastname: Franco
authors.forename: Franco
authors.initials: F
authors.lastname: Ionna
authors.forename: Antonia
authors.initials: A
authors.lastname: Feola
authors.forename: Alfredo
authors.initials: A
authors.lastname: De Rosa
authors.forename: Angela
authors.initials: A
authors.lastname: Santoro
authors.forename: Carolina
authors.initials: C
authors.lastname: Sbordone
authors.forename: Francesco
authors.initials: F
authors.lastname: Longo
authors.forename: Daniela
authors.initials: D
authors.lastname: Pasquali
authors.forename: Carla
authors.initials: C
authors.lastname: Loreto
authors.forename: Filippo
authors.initials: F
authors.lastname: Ricciardiello
authors.forename: Gennaro
authors.initials: G
authors.lastname: Esposito
authors.forename: Luigi
authors.initials: L
authors.lastname: D'Angelo
authors.forename: Angelo
authors.initials: A
authors.lastname: Itro
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Bufo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Tombolini
authors.forename: Rosario
authors.initials: R
authors.lastname: Serpico
authors.forename: Marina
authors.initials: M
authors.lastname: Di Domenico
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery*; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy