title: A novel HLA-DRB1 allele, HLA-DRB1*13:116, identified by sequencing-based typing in a member of the Czech National Marrow Donor Registry.
abstract: We describe the identification of a novel HLA-DRB1 allele, DRB1*13:116, in a member of the Czech National Marrow Donor Registry. The novel allele differs from the known DRB1*13:17 variant by a nucleotide exchange at position 227 (T/A) of the coding HLA-DRB1 sequence, which causes an amino acid substitution (Phe47Tyr) in the HLA-DR beta 1 chain.
authors.affiliation: HLA laboratory, Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Mrazek
authors.forename: J
authors.initials: J
authors.lastname: Onderkova
authors.forename: Z
authors.initials: Z
authors.lastname: Ambruzova
authors.forename: S
authors.initials: S
authors.lastname: Zachova
authors.forename: M
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D001853:Bone Marrow / Q000276:immunology / Q000502:physiology; D005260:Female; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012042:Registries; D014019:Tissue Donors
chemical_list: D059811:HLA-DRB1 Chains