title: Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models.
abstract: Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY, USA; Department of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA. Electronic address: hm2035@columbia.edu.
authors.forename: Holly
authors.initials: H
authors.lastname: Moore
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
authors.forename: Cameron S
authors.initials: CS
authors.lastname: Carter
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Barch
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000209:etiology* / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D009488:Neurosciences; D012559:Schizophrenia / Q000150:complications*
keywords: Behavior; CNTRICS; Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia; Mouse; Non-human primate; Psychopharmacology; Psychosis; Rat