title: Gadd45 in modulation of solid tumors and leukemia.
abstract: The stress response gadd45 gene family participates in cell cycle control, cell survival, apoptosis, maintenance of genomic stability, DNA repair, and active DNA demethylation, in response to environmental and physiological stress including oncogenic stress. Given these diverse functions, it is anticipated that gadd45 genes can influence the initiation and progression of malignancy and the response to different treatments. This chapter will provide an overview of how the different members of the gadd45 gene family are expressed in different tumors and leukemia, how this may impact on progression of disease, and what happens when expression is manipulated. Studies from human tumor/leukemia samples, cell lines, and animal models are included in this review. An overriding theme is that each of the gadd45 genes has both tumor suppressor and tumor promoter functions, dependent on the tissue/cell type and transforming event.
authors.affiliation: Temple University School of Medicine, Philadelphia, PA, USA, hoffman@temple.edu.
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoffman
authors.forename: Dan A
authors.initials: DA
authors.lastname: Liebermann
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics* / Q000378:metabolism; D017209:Apoptosis; D059447:Cell Cycle Checkpoints; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000235:genetics; D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D000097642:GADD45 Proteins
chemical_list: D000943:Antigens, Differentiation; D018797:Cell Cycle Proteins; D004247:DNA; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; C439070:GADD45A protein, human; D000097642:GADD45 Proteins; C086470:GADD45B protein, human; C485654:GADD45G protein, human