title: Micellization model for the polymerization of clathrin baskets.
abstract: A thermodynamic model is used to investigate the conditions under which clathrin triskelions form polyhedral baskets. The analysis, which is similar to classical methods used to study micelle formation, relates clathrin basket energetics to system parameters linked to triskelial rigidity, the natural curvature of an isolated triskelion, and interactions between triskelial legs in the assembled polyhedra. Mathematical theory predicts that a minimal ("critical") clathrin concentration, C(C), needs to be surpassed in order for basket polymerization to occur, and indicates how C(C), and the amount of polymerized material, depend on the chosen parameters. Analytical expressions are obtained to indicate how changes in the parameters affect the sizes of the polyhedra which arise when the total clathrin concentration exceeds C(C). A continuum analytic approximation then is used to produce numerical results that illustrate the derived dependences.
authors.affiliation: Polymer Science and Engineering Department, Physics Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: M
authors.initials: M
authors.lastname: Muthukumar
authors.forename: Ralph
authors.initials: R
authors.lastname: Nossal
mesh_terms: D002966:Clathrin / Q000138:chemical synthesis* / Q000737:chemistry; D008823:Micelles; D008956:Models, Chemical; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D002966:Clathrin; D008823:Micelles; D011108:Polymers