title: Lgr4 promotes glioma cell proliferation through activation of Wnt signaling.
abstract: The key signaling networks regulating glioma cell proliferation remain poorly defined. The leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) has been implicated in intestinal, gastric, and epidermal cell functions. We investigated whether Lgr4 functions in glioma cells and found that Lgr4 expression was significantly increased in glioma tissues. In addition, Lgr4 overexpression promoted while its knockdown using small interfering RNA oligos inhibited glioma cell proliferation. In addition, Wnt/β-catenin signaling was activated in cells overexpressing Lgr4. Therefore, our results revealed that Lgr4 activates Wnt/β-catenin signaling to regulate glioma cell proliferation.
authors.affiliation: Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China E-mail : Yun_huiLiu@126.com.
authors.forename: Chun-Yong
authors.initials: CY
authors.lastname: Yu
authors.forename: Guo-Biao
authors.initials: GB
authors.lastname: Liang
authors.forename: Peng
authors.initials: P
authors.lastname: Du
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Liu
mesh_terms: D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects*; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: C495270:CTNNB1 protein, human; C411562:LGR4 protein, human; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D043562:Receptors, G-Protein-Coupled; D051153:Wnt Proteins; D051176:beta Catenin