title: Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry.
abstract: We achieved continuous, noncontact wide-field imaging and characterization of drug release from a polymeric device in vitro by uniquely using off-axis interferometric imaging. Unlike the current gold-standard methods in this field, which are usually based on chromatography and spectroscopy, our method requires no user intervention during the experiment and involves less lab consumable instruments. Using a simplified interferometric imaging system, we experimentally demonstrate the characterization of anesthetic drug release (Bupivacaine) from a soy-based protein matrix, which is used as a skin substitute for wound dressing. Our results demonstrate the potential of interferometric imaging as an inexpensive and easy-to-use alternative for characterization of drug release in vitro.
authors.forename: Haniel
authors.initials: H
authors.lastname: Gabai
authors.forename: Maya
authors.initials: M
authors.lastname: Baranes-Zeevi
authors.forename: Meital
authors.initials: M
authors.lastname: Zilberman
authors.forename: Natan T
authors.initials: NT
authors.lastname: Shaked
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D007368:Interferometry; D008027:Light; D017768:Skin, Artificial; D013997:Time Factors