title: [Efficacy of mirabegron, a β3-adrenergic agonist, switched from an anticholinergic agent for female patients aged over 70 years].
abstract: In the present study, we investigated the efficacy of mirabegron, a β3-adrenergic agonist, in patients aged ＞70 years who did not respond to treatment with an anticholinergic agent. From February 2012 to May 2012, we examined 37 patients who did not respond to treatment with an anticholinergic agent. We assessed the overactive bladder symptom score (OABSS), thirst, and constipation at baseline, as well as at 3 and 6 months from the start of drug administration. Theme an age of the female patients was 79.9±6.08 years. The OABSS indicated significant improvement in nocturia and urge incontinence at 3 and 6 months. Furthermore, mirabegron significantly relieved thirst (in 95.2% of cases) and constipation (in 87.5% of cases). Thus, mirabegron is considered useful for female patients aged ＞70 years who did not respond to treatment with an anticholinergic agent.
authors.affiliation: Oomori Municipal Hospital.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D000083:Acetanilides / Q000008:administration & dosage*; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage*; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D057915:Drug Substitution; D005260:Female; D006801:Humans; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D000083:Acetanilides; D058666:Adrenergic beta-2 Receptor Agonists; D018680:Cholinergic Antagonists; D018727:Muscarinic Antagonists; D013844:Thiazoles; C520025:mirabegron