title: Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa.
abstract: Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.
authors.forename: Sonia
authors.initials: S
authors.lastname: Luque
authors.forename: Luisa
authors.initials: L
authors.lastname: Sorli
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Silvia
authors.initials: S
authors.lastname: Collado
authors.forename: Francesc
authors.initials: F
authors.lastname: Barbosa
authors.forename: Nuria
authors.initials: N
authors.lastname: Berenguer
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Horcajada
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003091:Colistin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000382:microbiology; D008297:Male; D011113:Polymyxins / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D006435:Renal Dialysis
chemical_list: D000900:Anti-Bacterial Agents; D011113:Polymyxins; D003091:Colistin
keywords: Colistin,; Haemodialysis,; Pharmacokinetics,; Pseudomonas aeruginosa; Renal insufficiency,