title: Polycomb group protein bodybuilding: working out the routines.
abstract: Polycomb group (PcG) proteins regulate gene expression by modifying chemical and structural properties of chromatin. Isono et al. (2013) now report in Developmental Cell a polymerization-dependent mechanism used by PcG proteins to form higher-order chromatin structures, referred to as Polycomb bodies, and demonstrate its necessity for gene silencing.
authors.affiliation: Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.
authors.forename: Cem
authors.initials: C
authors.lastname: Sievers
authors.forename: Renato
authors.initials: R
authors.lastname: Paro
mesh_terms: D000818:Animals; D020868:Gene Silencing; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism*; D063146:Polycomb-Group Proteins / Q000378:metabolism*; D055503:Protein Multimerization
chemical_list: C501292:Phc2 protein, mouse; D063146:Polycomb-Group Proteins; D063151:Polycomb Repressive Complex 2