title: Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators.
abstract: Parenteral nutrition (PN)-associated liver disease (PNALD) is a life-threatening complication of the administration of PN. The development of PNALD may be partly due to the composition of the lipid emulsion administered with PN: soybean oil-based lipid emulsions (SOLE) are associated with liver disease, while fish oil-based lipid emulsions (FOLE) are associated with prevention and improvement of liver disease. The objective of this study was to determine how the choice of lipid emulsion modified the production of bioactive lipid mediators (LMs). We utilized a mouse model of steatosis to study the differential effect of FOLE and SOLE. We subsequently validated these results in serum samples from a small cohort of human infants transitioning from SOLE to FOLE. In mice, FOLE was associated with production of anti-inflammatory, proresolving LMs; SOLE was associated with increased production of inflammatory LMs. In human infants, the transition from SOLE to FOLE was associated with a shift toward a proresolving lipidome. Together, these results demonstrate that the composition of the lipid emulsion directly modifies inflammatory homeostasis.
authors.affiliation: Boston Children's Hospital, 300 Longwood Ave., Fegan Bldg. 3rd Floor, Boston, MA 02115. mark.puder@childrens.harvard.edu.
authors.forename: Brian T
authors.initials: BT
authors.lastname: Kalish
authors.forename: Hau D
authors.initials: HD
authors.lastname: Le
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Fitzgerald
authors.forename: Samantha
authors.initials: S
authors.lastname: Wang
authors.forename: Kyle
authors.initials: K
authors.lastname: Seamon
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Gura
authors.forename: Karsten
authors.initials: K
authors.lastname: Gronert
authors.forename: Mark
authors.initials: M
authors.lastname: Puder
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004655:Emulsions; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D013024:Soybean Oil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004655:Emulsions; D015525:Fatty Acids, Omega-3; D018836:Inflammation Mediators; D013024:Soybean Oil
keywords: lipid mediators; liver disease; omega-3; omega-6; parenteral nutrition