title: Copper-catalyzed trifluoromethyl thiolation--mild and efficient synthesis of trifluoromethyl thioethers.
abstract: Mild-mannered sulfur: A general method for the synthesis of vinyl trifluoromethyl thioethers starting from readily available di-, tri-, and tetrasubstituted vinyl iodides was developed. A wide variety of substrates were applied in the reaction with CuSCF3 to give the corresponding products in high yields, within short reaction times, with retention of the initial E/Z isomer ratio. In addition, a copper-catalyzed trifluoromethyl thioether protocol has been also developed.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany). Magnus.Rueping@rwth-aachen.de.
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
authors.forename: Nikita
authors.initials: N
authors.lastname: Tolstoluzhsky
authors.forename: Pavlo
authors.initials: P
authors.lastname: Nikolaienko
keywords: CS bond formation; copper; thioethers; trifluoromethyl thiolation; vinyl iodide