title: [Leptospirosis in Libreville (Gabon): four cases].
abstract: OBJECTIVE
  Leptospirosis is an endemic disease in tropical countries, where it is characterized by clinical polymorphism. We report four cases of leptospirosis diagnosed at the military hospital of Libreville (Gabon).
  
  
  METHODS
  Four men aged 16 to 31-years-old, were admitted for febrile jaundice, with impaired general condition and pain. All lived in disadvantaged neighborhoods in the capital. In each case, the laboratory workups found hepatic cytolysis, renal failure, hyperleukocytosis, anemia, and an inflammatory state. Serology was negative for hepatitis B and C and for HIV, as was testing for malaria. The failure to respond to presumptive antimalarial treatment suggested leptospirosis, and the diagnosis was confirmed in every case by positive serologies with significant antibody titers. The course was quickly favorable under treatment by an appropriate antibiotic; liver and kidney function returned to normal within a few days.
  
  
  CONCLUSIONS
  In tropical zones, the diagnosis of leptospirosis must be considered in all cases of febrile jaundice, especially when liver and kidney function are impaired.
authors.affiliation: Hôpital des armées, médecine, 20404 Libreville, Gabon.
authors.forename: M C
authors.initials: MC
authors.lastname: Magne
authors.forename: M
authors.initials: M
authors.lastname: Ondounda
authors.forename: L G
authors.initials: LG
authors.lastname: Mbethe
authors.forename: D
authors.initials: D
authors.lastname: Mounguengui
authors.forename: J R
authors.initials: JR
authors.lastname: Nzenze
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000740:Anemia / Q000188:drug therapy / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D003402:Creatine Kinase; D005681:Gabon; D006801:Humans; D007922:Leptospirosis / Q000175:diagnosis* / Q000188:drug therapy; D007964:Leukocytosis / Q000188:drug therapy / Q000382:microbiology; D008107:Liver Diseases / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D011204:Poverty Areas; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D000658:Amoxicillin; D003402:Creatine Kinase
keywords: Gabon; diagnosis; febrile jaundice; leptospirosis