title: Onset and duration of effect of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA in the treatment of glabellar frown lines: a randomized, double-blind study.
abstract: BACKGROUND
  Three botulinum neurotoxin type A preparations (incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA) are widely approved in Europe and in the US for the treatment of glabellar frown lines. The purpose of this study was to determine and compare the time to onset and duration of treatment effect of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA for the treatment of glabellar frown lines.
  
  
  METHODS
  Subjects aged 20-60 years with moderate to severe glabellar frown lines received one treatment of either 21 units (U) incobotulinumtoxinA, 21 U onabotulinumtoxinA, or 63 U abobotulinumtoxinA. Assessments were made over a period of 180 days. Onset of treatment effect was defined as the day that the observer noted a decrease in glabellar muscle activity compared with baseline photographs and videos. Duration of treatment effect was defined as the time until glabellar muscle action returned to the baseline level. Analyses were performed using a Weibull log(T) regression model.
  
  
  RESULTS
  The study enrolled 180 subjects; 60 per group. For all three products, onset of treatment effect occurred earlier in female subjects compared to male subjects. For both sexes, a significantly earlier time to onset of treatment effect was seen for incobotulinumtoxinA compared to onabotulinumtoxinA and abobotulinumtoxinA; in female subjects these times were 3.02 days, 5.29 days, and 5.32 days, respectively. The duration of treatment effect was longer for incobotulinumtoxinA compared to onabotulinumtoxinA and abobotulinumtoxinA; for all products, treatment effect duration was longer in females than in males. Time to onset was not a predictor of treatment duration.
  
  
  CONCLUSIONS
  IncobotulinumtoxinA demonstrated a more rapid onset and a longer duration of treatment effect than onabotulinumtoxinA (1:1 dose ratio) and abobotulinumtoxinA (1:3 dose ratio). Onset of effect was faster and duration of effect was longer in female subjects compared to male subjects.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Medical University Graz, Graz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Rappl
authors.forename: Daryousch
authors.initials: D
authors.lastname: Parvizi
authors.forename: Herwig
authors.initials: H
authors.lastname: Friedl
authors.forename: Maria
authors.initials: M
authors.lastname: Wiedner
authors.forename: Simone
authors.initials: S
authors.lastname: May
authors.forename: Bettina
authors.initials: B
authors.lastname: Kranzelbinder
authors.forename: Paul
authors.initials: P
authors.lastname: Wurzer
authors.forename: Bengt
authors.initials: B
authors.lastname: Hellbom
keywords: botulinum neurotoxin type A; glabellar frown lines; incobotulinumtoxinA; regression analysis