title: Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms.
abstract: The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.
authors.forename: Ahmet Oguz
authors.initials: AO
authors.lastname: Ada
authors.forename: Canan
authors.initials: C
authors.lastname: Demiroglu
authors.forename: Meltem
authors.initials: M
authors.lastname: Yilmazer
authors.forename: Halit Sinan
authors.initials: HS
authors.lastname: Suzen
authors.forename: Ali Eba
authors.initials: AE
authors.lastname: Demirbag
authors.forename: Sibel
authors.initials: S
authors.lastname: Efe
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Alemdar
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Iscan
authors.forename: Sema
authors.initials: S
authors.lastname: Burgaz
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000139:chemically induced*; D003032:Coal Mining; D019363:Cytochrome P-450 CYP1A1 / Q000187:drug effects* / Q000235:genetics*; D065633:Cytochrome P-450 CYP1B1 / Q000187:drug effects / Q000235:genetics; D004851:Epoxide Hydrolases / Q000187:drug effects / Q000235:genetics; D005787:Gene Frequency / Q000187:drug effects; D051549:Glutathione S-Transferase pi / Q000187:drug effects / Q000235:genetics; D005982:Glutathione Transferase / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects*; D011110:Polymorphism, Genetic / Q000187:drug effects*
chemical_list: D019363:Cytochrome P-450 CYP1A1; D065633:Cytochrome P-450 CYP1B1; D004851:Epoxide Hydrolases; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D011084:Polycyclic Aromatic Hydrocarbons; C569463:CYP1A1 protein, human; C585496:CYP1B1 protein, human; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human; C522330:EPHX1 protein, human