title: Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses.
abstract: We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with immunostimulatory and tumoricidal functions. Our study demonstrates the potential use of MDSCs as a Trojan horse for the tumor-targeted delivery of various anticancer therapeutics.
authors.affiliation: Department of Oncological Sciences; Icahn School of Medicine at Mount Sinai; New York, NY USA ; Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai; New York, NY USA.
authors.forename: Ping-Ying
authors.initials: PY
authors.lastname: Pan
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Shu-Hsia
authors.initials: SH
authors.lastname: Chen