title: Pharmacological agents currently in clinical trials for disorders in neurogastroenterology.
abstract: Esophageal, gastrointestinal, and colonic diseases resulting from disorders of the motor and sensory functions represent almost half the patients presenting to gastroenterologists. There have been significant advances in understanding the mechanisms of these disorders, through basic and translational research, and in targeting the receptors or mediators involved, through clinical trials involving biomarkers and patient responses. These advances have led to relief of patients' symptoms and improved quality of life, although there are still significant unmet needs. This article reviews the pipeline of medications in development for esophageal sensorimotor disorders, gastroparesis, chronic diarrhea, chronic constipation (including opioid-induced constipation), and visceral pain.
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000188:drug therapy; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000627:therapeutic use; D058748:Pain Perception / Q000187:drug effects; D010291:Paresis / Q000188:drug therapy; D018689:Sensory System Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D018377:Neurotransmitter Agents; D018689:Sensory System Agents