title: Antibacterial activity of some 5-dialkylaminomethylhydantoins and related derivatives.
abstract: In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C₂-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.
authors.affiliation: Faculty of Pharmaceutical Science, Fukuoka University.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Fujisaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Toyofuku
authors.forename: Mayu
authors.initials: M
authors.lastname: Egami
authors.forename: Shiori
authors.initials: S
authors.lastname: Ishida
authors.forename: Naho
authors.initials: N
authors.lastname: Nakamoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kashige
authors.forename: Fumio
authors.initials: F
authors.lastname: Miake
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006827:Hydantoins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006827:Hydantoins