title: Resolution of terminal 1,2-diols via silyl transfer.
abstract: Through kinetic analysis and optimization, we report an improved resolution of terminal 1,2-diols via asymmetric silyl transfer. Because the reaction is a regiodivergent resolution, the monoprotected product could be isolated in excess of 95:5 er and 40% yield. The described method offers a means of chemically differentiating a terminal 1,2-diol with concomitant resolution of the enantiomers.
authors.affiliation: Boston College , 2609 Beacon Street, Chestnut Hill, Massachusetts 02467-3860, United States.
authors.forename: Xixi
authors.initials: X
authors.lastname: Sun
authors.forename: Amanda D
authors.initials: AD
authors.lastname: Worthy
authors.forename: Kian L
authors.initials: KL
authors.lastname: Tan
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D012821:Silanes