title: Analysis of an intronic promoter within Synj2.
abstract: Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 transcripts led us to uncover a novel subset of transcripts that appears to derive from a region located within intron 7. We identified two alternate splice variants emanating from use of this promoter. These alternate splice variants manifest developmental stage specificity and somatic versus gametic differences in expression.
authors.affiliation: Department of Biological Sciences, North Carolina State University, Campus Box 7617, Raleigh, NC 27695, USA. Electronic address: ajplanch@ncsu.edu.
authors.forename: Antonio
authors.initials: A
authors.lastname: Planchart
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D007438:Introns; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D011401:Promoter Regions, Genetic; D013091:Spermatogenesis / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D020121:5' Untranslated Regions; D009419:Nerve Tissue Proteins; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases
keywords: Inositol polyphosphate phosphatase; Mouse; Non-canonical promoter; Spermatogenesis; Synaptojanin