title: Advances in hematopoietic stem cell transplantation in chronic myeloid leukemia.
abstract: Treatment of chronic myeloid leukemia (CML) has evolved dramatically with the development of tyrosine kinase inhibitors (TKIs). This past decade also witnessed major advances in the field of allogeneic hematopoietic stem cell transplantation (alloHSCT) that led to better patients' outcomes. Progress in the exploitation of alternative sources of stem cells, development of novel conditioning regimens, discovery of innovative graft-versus-host prophylactic strategies, and advances in supportive care as well as positioning of alloHSCT in the overall management of CML are discussed in this article.
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Veldman
authors.forename: Fuad
authors.initials: F
authors.lastname: El Rassi
authors.forename: Stacie
authors.initials: S
authors.lastname: Holloway
authors.forename: Amelia
authors.initials: A
authors.lastname: Langston
authors.forename: Hanna Jean
authors.initials: HJ
authors.lastname: Khoury
mesh_terms: D015897:Comorbidity; D018380:Hematopoietic Stem Cell Transplantation / Q000639:trends*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007165:Immunosuppression Therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D014184:Transplantation, Homologous