title: Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia.
abstract: Resting state electroencephalogram (EEG) abnormalities in schizophrenia and bipolar disorder patients suggest alterations in neural oscillatory activity. However, few studies directly compare these anomalies between patient groups, and none have examined EEG coherence. Therefore, this study investigated whether these electrophysiological characteristics differentiate clinical populations from one another, and from non-psychiatric controls. To address this question, resting EEG power and coherence were assessed in 76 bipolar patients (BP), 132 schizophrenia patients (SZ), and 136 non-psychiatric controls (NC). We conducted separate repeated-measures ANOVAs to examine group differences within seven frequency bands across several brain regions. BP showed significantly greater power relative to SZ at higher frequencies including Beta and Gamma across all regions. In terms of intra-hemispheric coherence, while SZ generally exhibited higher coherence at Delta compared to NC and BP, both SZ and BP showed higher coherence at Alpha1 and Alpha2. In contrast, BP and HC showed higher coherence within hemispheres compared to SZ at Beta 1. In terms of inter-hemispheric coherence, SZ displayed higher coherence compared to NC at temporal sites at both Alpha1 and Alpha2. Taken together, BP exhibited increased high frequency power with few disruptions in neural synchronization. In contrast, SZ generally exhibited enhanced synchronization within and across hemispheres. These findings suggest that resting EEG can be a sensitive measure for differentiating between clinical disorders.
authors.affiliation: Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B.C. V6T 1Z4, Canada. Electronic address: kamjulia@gmail.com.
authors.forename: Julia W Y
authors.initials: JW
authors.lastname: Kam
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Bolbecker
authors.forename: Brian F
authors.initials: BF
authors.lastname: O'Donnell
authors.forename: William P
authors.initials: WP
authors.lastname: Hetrick
authors.forename: Colleen A
authors.initials: CA
authors.lastname: Brenner
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology*; D001931:Brain Mapping; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D012146:Rest; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents
keywords: Bipolar disorder; EEG; Neural synchronization; Power; Resting state; Schizophrenia