title: Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome.
abstract: OBJECTIVE
  Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS).
  
  
  METHODS
  High-sensitivity cTnI levels were measured at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS patients from the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV trial.
  
  
  RESULTS
  Patients with moderately increased cTnI levels and without a relevant decrease over time had a significantly raised mortality at 30 days and 1 year. No relevant associations between cTnI changes and recurrent myocardial infarction were seen.
  
  
  CONCLUSIONS
  The cTnI change is predictive for subsequent mortality in selected conservatively managed NSTE-ACS patients.
authors.affiliation: Cardiology Unit, Department of Medical Sciences, Faculty of Medicine, Uppsala University , Uppsala , Sweden and.
authors.forename: Kai M
authors.initials: KM
authors.lastname: Eggers
authors.forename: Stefan
authors.initials: S
authors.lastname: James
authors.forename: Per
authors.initials: P
authors.lastname: Venge
authors.forename: Bertil
authors.initials: B
authors.lastname: Lindahl
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000503:physiopathology*; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I