title: The CBL-CIPK network mediates different signaling pathways in plants.
abstract: The calcineurin B-like protein-CBL-interacting protein kinase (CBL-CIPK) signaling pathway in plants is a Ca²⁺-related pathway that responds strongly to both abiotic and biotic environmental stimuli. The CBL-CIPK system shows variety, specificity, and complexity in response to different stresses, and the CBL-CIPK signaling pathway is regulated by complex mechanisms in plant cells. As a plant-specific Ca²⁺ sensor relaying pathway, the CBL-CIPK pathway has some crosstalk with other signaling pathways. In addition, research has shown that there is crosstalk between the CBL-CIPK pathway and the low-K⁺ response pathway, the ABA signaling pathway, the nitrate sensing and signaling pathway, and others. In this paper, we summarize and review research discoveries on the CBL-CIPK network. We focus on the different modification and regulation mechanisms (phosphorylation and dephosphorylation, dual lipid modification) of the CBL-CIPK network, the expression patterns and functions of CBL-CIPK network genes, the responses of this network to abiotic stresses, and its crosstalk with other signaling pathways. We also discuss the technical research methods used to analyze the CBL-CIPK network and some of its newly discovered functions in plants.
authors.affiliation: School of Life Science and Biotechnology, Dalian University of Technology, Linggong Road No. 2, Dalian, Liaoning, China, qinyangyu@gmail.com.
authors.forename: Qinyang
authors.initials: Q
authors.lastname: Yu
authors.forename: Lijia
authors.initials: L
authors.lastname: An
authors.forename: Wenli
authors.initials: W
authors.lastname: Li
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism; D017360:Arabidopsis / Q000235:genetics / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D053263:Gene Regulatory Networks; D008954:Models, Biological; D009566:Nitrates / Q000378:metabolism; D010766:Phosphorylation; D010937:Plant Growth Regulators / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D029681:Arabidopsis Proteins; C417306:CBL protein, Arabidopsis; D002135:Calcium-Binding Proteins; D009566:Nitrates; D010937:Plant Growth Regulators; D015221:Potassium Channels; D000040:Abscisic Acid; D011494:Protein Kinases; D002118:Calcium