title: Silicon Nanotweezers with a microfluidic cavity for the real time characterization of DNA damage under therapeutic radiation beams.
abstract: We report the biomechanical characterization of λ-DNA bundle exposed to a therapeutic radiation beam by silicon Nanotweezers. The micromechanical device endures the harsh environment of radiation beams, and still retains molecular-level detection accuracy. The real-time DNA bundle degradation is observed in terms of biomechanical stiffness and viscosity reduction, both in air and in solution. These results pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Perret
authors.forename: Po-Tsun
authors.initials: PT
authors.lastname: Chiang
authors.forename: Thomas
authors.initials: T
authors.lastname: Lacornerie
authors.forename: Momoko
authors.initials: M
authors.lastname: Kumemura
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lafitte
authors.forename: Herve
authors.initials: H
authors.lastname: Guillou
authors.forename: Laurent
authors.initials: L
authors.lastname: Jalabert
authors.forename: Eric
authors.initials: E
authors.lastname: Lartigau
authors.forename: Teruo
authors.initials: T
authors.lastname: Fujii
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Cleri
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujita
authors.forename: Dominique
authors.initials: D
authors.lastname: Collard
mesh_terms: D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D004249:DNA Damage; D055617:Micro-Electrical-Mechanical Systems; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008846:Micromanipulation; D036103:Nanotechnology / Q000295:instrumentation*; D012825:Silicon / Q000737:chemistry*; D014965:X-Rays
chemical_list: D004247:DNA; D012825:Silicon