title: GPR48 promotes multiple cancer cell proliferation via activation of Wnt signaling.
abstract: The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. In the present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87 and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interfering RNA oligos inhibits cell proliferation. In addition, Wnt/β-catenin signaling was activated in cells overexpressing GPR48. Therefore, our results indicated that GPR48 activates Wnt/β-catenin signaling to regulate cancer cell proliferation.
authors.affiliation: Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China E-mail : Loufangzj@163.com.
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Hai-Na
authors.initials: HN
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Lou
mesh_terms: D015153:Blotting, Western; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D034741:RNA, Small Interfering / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: C411562:LGR4 protein, human; D034741:RNA, Small Interfering; D043562:Receptors, G-Protein-Coupled; D051153:Wnt Proteins