title: Integrating advances in insulin into clinical practice: Overview of current insulin formulations.
abstract: Defects in both insulin secretion and function play a fundamental role in the pathophysiologic mechanisms underlying both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). As the most physiologic treatment option available, insulin plays a central role in the management of patients with T1DM and a growing role in the management of patients with T2DM, as is reflected in current treatment guidelines.
authors.affiliation: Johnston Memorial Diabetes Care Center Abingdon, VA, USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Rhinehart
mesh_terms: D002626:Chemistry, Pharmaceutical; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000069057:Insulin Detemir; D000069036:Insulin Glargine; D007336:Insulin, Isophane / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D049528:Insulin, Long-Acting / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D061266:Insulin, Short-Acting / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D061385:Insulins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting; D061266:Insulin, Short-Acting; D061385:Insulins; D000069036:Insulin Glargine; D000069057:Insulin Detemir; D007336:Insulin, Isophane