title: Photodynamic cell membrane perforation for intracellular electrodes.
abstract: We report a new aspect of rapid (<10 seconds) light-induced cell membrane perforation for intracellular electrode by Hematoporphyrin (HP), which is an original photosensitizer for photodynamic therapy concept. A microelectrode insertion process to cell could be improved by pinpoint use of the photosensitizing effect to degenerate cell membranes prior to insertion. According to the concept, simple electrode coating with photosensitizer will enable intracellular electrode array for neural engineering.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shibata
authors.forename: Shuhei
authors.initials: S
authors.lastname: Kashiwazaki
authors.forename: Takashi K
authors.initials: TK
authors.lastname: Saito
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000528:radiation effects; D004560:Electricity; D004566:Electrodes; D055724:Electrophysiological Phenomena / Q000187:drug effects / Q000528:radiation effects; D006415:Hematoporphyrins / Q000494:pharmacology*; D042541:Intracellular Space / Q000187:drug effects* / Q000528:radiation effects*; D008845:Microinjections; D016716:PC12 Cells; D010778:Photochemotherapy; D051381:Rats; D012815:Signal Processing, Computer-Assisted
chemical_list: D006415:Hematoporphyrins