title: A meta-analysis: neoadjuvant chemotherapy versus primary surgery in ovarian carcinoma FIGO stageIII and IV.
abstract: BACKGROUND
  The purpose of the current study is to analyze the existing data comparing neoadjuvant chemotherapy with primary debulking surgery (PDS) in patients with advanced ovarian carcinoma.
  
  
  METHODS
  Patients with stage IIIC and IV ovarian cancer were identified from articles in Medline, PubMed, Cochrane Library, and EMBASE database (1989 to February 2013). Two authors independently extracted the data. To assess the risk of bias of included literatures, Cochrane Collaboration's risk of bias tool was used. Meta-analysis on literatures was conducted by using RevMan 5.2 software.
  
  
  RESULTS
  Two high-quality randomized controlled trials (RCTs) met the inclusion criteria. These multicenter trials randomized 1,220 women with stage IIIc/IV ovarian cancer to NACT or PDS followed by chemotherapy. There were no significant differences between the study groups with regard to overall survival (OS) (1,120 women; HR 0.98; 95% CI 0.85 to 1.14) or progression-free survival (PFS) (1,120 women; HR 1.03; 95% CI 0.91 to 1.16).
  
  
  CONCLUSIONS
  There was no statistical difference in median OS and PFS between the two treatment groups. With regard to selecting who will benefit from NACT, treatment should be tailored to the patient and should take into account respectability, age, histology, stage, and performance status.
authors.affiliation: Department of Oncology, the First Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, People's Republic of China. mdylx@163.com.
authors.forename: Ma
authors.initials: M
authors.lastname: Dai-yuan
authors.forename: Tan
authors.initials: T
authors.lastname: Bang-xian
authors.forename: Li
authors.initials: L
authors.lastname: Xian-fu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ye-qin
authors.forename: Cai
authors.initials: C
authors.lastname: Hong-Wei
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D010052:Ovariectomy; D011379:Prognosis