title: Association of survivin polymorphisms with tumor susceptibility: a meta-analysis.
abstract: BACKGROUND
  The survivin polymorphisms have been shown to confer genetic susceptibility to various tumors, but the results are inconsistent. In order to accomplish a more precise estimation of the relationship, a meta-analysis was performed.
  
  
  RESULTS
  For rs9904341, a significantly increased tumor risk was found in overall meta-analysis under C/C vs. G/G (OR = 1.40, 95% CI = 1.13-1.74, p = 0.002), dominant (OR = 1.18, 95% CI = 1.01-1.38, p = 0.039) and recessive (OR = 1.34, 95% CI = 1.13-1.58, p = 0.001) genetic models and Asians group. In subgroup analyses of tumor types, we found a significant association between this SNP and an increased risk of gastric, colorectal, bladder and other tumors as well as a decreased risk of hepatocellular cancer. For rs17878467, a significantly decreased tumor risk was identified in overall meta-analysis for allele contrast (T vs. C: OR = 0.69, 95% CI = 0.51-0.92, p = 0.012), C/T vs. C/C (OR = 0.61, 95% CI = 0.42-0.88, p = 0.009) and dominant (OR = 0.62, 95% CI = 0.43-0.88, p = 0.007) genetic models and Asians group. For rs2071214, we found a significant association between this SNP and an increased tumor risk in overall meta-analysis under G/G vs. A/A (OR = 1.51, 95% CI = 1.04-2.18, p = 0.029) and recessive (OR = 1.54, 95% CI = 1.07-2.22, p = 0.020) genetic models and Asians group. Besides, there was a significant association of rs8073069 with an increased tumor risk under recessive genetic model (OR = 1.37, 95% CI = 1.01-1.84, p = 0.040), while no significant association between rs1042489 and tumor risk was detected.
  
  
  CONCLUSIONS
  The survivin rs9904341 most likely contributed to increased susceptibility to tumor in Asians as well as to gastric, colorectal and bladder cancers. As for rs17878467, the T allele might be a protective factor for tumor, especially in Asians. Moreover, the survivin rs8073069 and rs2071214 seemed to be associated with an increased tumor risk in Asians, while there was no association between the survivin rs1042489 and tumor risk.
authors.affiliation: Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Li
authors.forename: Shisheng
authors.initials: S
authors.lastname: Zhu
authors.forename: Renkuan
authors.initials: R
authors.lastname: Tang
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianbo
authors.initials: J
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D019295:Computational Biology; D005808:Genes, Recessive / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin