title: Mechanisms of drug-induced liver injury.
abstract: Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).
authors.affiliation: USC Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue (HMR101), Los Angeles, CA 90033, USA.
authors.forename: Liyun
authors.initials: L
authors.lastname: Yuan
authors.forename: Neil
authors.initials: N
authors.lastname: Kaplowitz
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D006801:Humans
keywords: Adaptive immunity; Cell death; HLA associations; Idiosyncratic drug-induced liver injury; Mitochondria; Oxidative stress; Reactive metabolites; Stress signaling