title: Diabetic nephropathy: diagnosis and treatment.
abstract: Nephropathy remains a major cause of morbidity and a key determinant of mortality in patients with type 1 or type 2 diabetes mellitus. Research is ongoing to identify biomarkers that in addition to albuminuria and glomerular filtration rate assist in the prediction and monitoring of renal disease in diabetes mellitus. Current strategies to treat this condition focus on intensification of glycaemic control and excellent control of blood pressure using regimens based on blockade of the renin-angiotensin system. Other approaches to control blood pressure and afford renoprotection are under active clinical investigation, including renal denervation and endothelin receptor antagonism. With increasing understanding of the underlying pathophysiological processes implicated in diabetic nephropathy, new specific renoprotective treatment strategies are anticipated to become available over the next few years.
authors.affiliation: Diabetes Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Vic 3004, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Fineberg
authors.forename: Karin A M
authors.initials: KA
authors.lastname: Jandeleit-Dahm
authors.forename: Mark E
authors.initials: ME
authors.lastname: Cooper
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents