title: Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China.
abstract: α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 317 AFPGC patients, from 11 clinical studies in China with a general AFPGC/GC ratio of 6.63% were summarized and analyzed. On the basis of analysis of the clinical data, the patients with AFPGC had larger tumor size, weaker cell differentiation, worse histopathological types, deeper serosal infiltration, more lymph node and liver metastases, poorer stages, shorter survival time and more positive expression of vascular endothelial growth factors than the patients without AFPGC. Our observation is consistent with previous results reported in studies of AFPGC. Overall, AFPGC is a subtype of GC with a poor prognosis.
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People's Republic of China. wcpjjt@163.com.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: Chang-Ping
authors.initials: CP
authors.lastname: Wu
authors.forename: Mei
authors.initials: M
authors.lastname: Ji
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Binfeng
authors.initials: B
authors.lastname: Lu
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shi
authors.forename: Jing-Ting
authors.initials: JT
authors.lastname: Jiang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins