title: [Advance of lung cancer screening with low-dose spiral CT].
abstract: Lung cancer has become the leading cause of cancer mortality globally, and 5-year survival rate is very poor. Screening and early detection are vital to improve survival and decrease mortality of lung cancer. In recent 20 years, low-dose spiral CT (LDCT) screening has become a research focus in this area. Randomized controlled trials have confirmed that LDCT can decrease lung cancer mortality. However, there are still some problems of LDCT. In this paper, we summarized the controversy that whether low-dose helical CT screening can reduce lung cancer mortality or not before its effectiveness was been confirmed, the results and problems in the randomized controlled trials and gave a prospect of low-dose helical CT screening's future application.
authors.affiliation: Peking Union Medical College & Institute of radiation medicine, Chinese Academy of Medical Science, Tianjin 300192, China.
authors.forename: Guanhua
authors.initials: G
authors.lastname: Ren
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Fan
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000401:mortality; D016032:Randomized Controlled Trials as Topic; D036542:Tomography, Spiral Computed / Q000379:methods*