title: Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers.
abstract: The effects of a β-dunnione compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover.
authors.affiliation: College of Advanced Science, Dankook University, Cheonan, Korea.
authors.forename: In-Geun
authors.initials: IG
authors.lastname: Jo
authors.forename: Dongsun
authors.initials: D
authors.lastname: Park
authors.forename: Jangbeen
authors.initials: J
authors.lastname: Kyung
authors.forename: Dajeong
authors.initials: D
authors.lastname: Kim
authors.forename: Jingmei
authors.initials: J
authors.lastname: Cai
authors.forename: Jihyun
authors.initials: J
authors.lastname: Kim
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kwak
authors.forename: Sang-Ku
authors.initials: SK
authors.lastname: Yoo
authors.forename: Heon-Sang
authors.initials: HS
authors.lastname: Jeong
authors.forename: Yun-Bae
authors.initials: YB
authors.lastname: Kim
keywords: Gastric secretion; MB12662; alcohol; stress; ulcer; β-dunnione