title: Molecular epidemiology of Escherichia coli sequence type 131 and Its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago Region, 2007 to 2010.
abstract: We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.
authors.affiliation: Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Ritu
authors.initials: R
authors.lastname: Banerjee
authors.forename: Ari
authors.initials: A
authors.lastname: Robicsek
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kuskowski
authors.forename: Stephen
authors.initials: S
authors.lastname: Porter
authors.forename: Brian D
authors.initials: BD
authors.lastname: Johnston
authors.forename: Evgeni
authors.initials: E
authors.lastname: Sokurenko
authors.forename: Veronika
authors.initials: V
authors.lastname: Tchesnokova
authors.forename: Lance B
authors.initials: LB
authors.lastname: Price
authors.forename: James R
authors.initials: JR
authors.lastname: Johnson
mesh_terms: D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D017720:Molecular Epidemiology; D014774:Virulence / Q000235:genetics / Q000502:physiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases