title: SLC30A8 nonsynonymous variant is associated with recovery following exercise and skeletal muscle size and strength.
abstract: Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults-the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)-were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training.
authors.affiliation: Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC.
authors.forename: Courtney
authors.initials: C
authors.lastname: Sprouse
authors.forename: Heather
authors.initials: H
authors.lastname: Gordish-Dressman
authors.forename: E Funda
authors.initials: EF
authors.lastname: Orkunoglu-Suer
authors.forename: Jason S
authors.initials: JS
authors.lastname: Lipof
authors.forename: Stephanie
authors.initials: S
authors.lastname: Moeckel-Cole
authors.forename: Ronak R
authors.initials: RR
authors.lastname: Patel
authors.forename: Kasra
authors.initials: K
authors.lastname: Adham
authors.forename: Justin S
authors.initials: JS
authors.lastname: Larkin
authors.forename: Monica J
authors.initials: MJ
authors.lastname: Hubal
authors.forename: Amy K
authors.initials: AK
authors.lastname: Kearns
authors.forename: Priscilla M
authors.initials: PM
authors.lastname: Clarkson
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Angelopoulos
authors.forename: Paul M
authors.initials: PM
authors.lastname: Gordon
authors.forename: Niall M
authors.initials: NM
authors.lastname: Moyna
authors.forename: Linda S
authors.initials: LS
authors.lastname: Pescatello
authors.forename: Paul S
authors.initials: PS
authors.lastname: Visich
authors.forename: Robert F
authors.initials: RF
authors.lastname: Zoeller
authors.forename: Eric P
authors.initials: EP
authors.lastname: Hoffman
authors.forename: Laura L
authors.initials: LL
authors.lastname: Tosi
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Devaney
mesh_terms: D000293:Adolescent; D000328:Adult; D027682:Cation Transport Proteins / Q000235:genetics*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D055070:Resistance Training; D000075703:Zinc Transporter 8
chemical_list: D027682:Cation Transport Proteins; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8