title: A genome-wide analysis of annexins from parasitic organisms and their vectors.
abstract: In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene duplication as a major evolutionary event in annexin genesis. This study illuminates annexin diversity from a novel perspective using contemporary phylogenetic hypotheses of eukaryote evolution, and will aid the consolidation of annexin protein identities in public databases and provide a foundation for future functional analysis and characterisation of these proteins in parasites of socioeconomic importance.
authors.affiliation: 1] Centre for Biodiscovery and Molecular Development of Therapeutics, Queensland Tropical Health Alliance, James Cook University, Cairns, Queensland, Australia [2].
authors.forename: Cinzia
authors.initials: C
authors.lastname: Cantacessi
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Seddon
authors.forename: Terrence L
authors.initials: TL
authors.lastname: Miller
authors.forename: Chiuan Yee
authors.initials: CY
authors.lastname: Leow
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Thomas
authors.forename: Lyndel
authors.initials: L
authors.lastname: Mason
authors.forename: Charlene
authors.initials: C
authors.lastname: Willis
authors.forename: Giselle
authors.initials: G
authors.lastname: Walker
authors.forename: Alex
authors.initials: A
authors.lastname: Loukas
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Jones
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D017302:Annexins / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D030541:Databases, Genetic; D019143:Evolution, Molecular; D055106:Genome-Wide Association Study; D006801:Humans; D007448:Invertebrates / Q000145:classification / Q000235:genetics; D010802:Phylogeny
chemical_list: D017302:Annexins