title: Comparative study of tomato and tomato paste supplementation on the level of serum lipids and lipoproteins levels in rats fed with high cholesterol.
abstract: BACKGROUND
  Hypercholesterolemia is one of the risk factors of cardiovascular diseases. Increased blood cholesterol affects general health and increases mortality due to cardiovascular disease. Poor nutrition increases LDL cholesterol and decreases LDL receptor activities in the liver. Scientists have shown that consumption of antioxidants can reduce hypercholesterolemia and proved benefits of fruit and vegetables. Tomato reduces oxidative stress by increasing serum total antioxidant level.
  
  
  OBJECTIVE
  This study compared the tomato and tomato paste supplementation on the level of serum lipids and lipoproteins in rats fed with high cholesterol.
  
  
  METHODS
  In this study, four male rat groups (10 rats per group) were used. Control group received basal diet, second group received basal diet and 2% cholesterol (Chol), third and fourth groups received basal diet, 2% cholesterol tomato and tomato paste respectively (20 percent of the diet) for a month. Then serum TC, LDL, HDL and TG were measured.
  
  
  RESULTS
  Results showed that in Chol group, all lipids increased significantly (P < 0.05) except HDL compared to the control group. Tomato and tomato paste supplementation decreased TC, LDL and TG concentration significantly (P < 0.05) compared to Chol group. Tomato paste had the higher effect on lipids decreasing than tomato.
  
  
  CONCLUSIONS
  Decreases of TC, LDL and TG may be related to tomato antioxidant effect. This course in human required more investigations.
authors.affiliation: Department of Pharmacology and Toxicology, Veterinary Faculty, Islamic Azad University, Tabriz Branch, Tabriz, IR Iran.
authors.forename: Mir Hadi
authors.initials: MH
authors.lastname: Khayat Nouri
authors.forename: Ali
authors.initials: A
authors.lastname: Namvaran Abbas Abad
keywords: Hypercholesterolemia; Lipoproteins; Lycopersicon Esculentum; Rats