title: [The relationship between selenium and gastrointestinal inflammatory diseases].
abstract: The cell-membrane toxicity of reactive oxygen and nitrogen species (RONS) plays an increasing role in the pathomechanism of gastrointestinal tract diseases. Trace elements are important parts of antioxidant protecting system, especially the selenium (Se), which, in the form of glutathione peroxidase contributes to the immunity of the gut (GALT). Due to the absorptional disorders and consequent malnutrition observed in the course of inflammatory bowel diseases (IBD) an important role is associated with nutritional therapy, including energy-, protein- and trace element-support. Human studies show, that IBD is mostly accompanied by lower serum Se concentrations, reduced antoxidant and increased proinflammatory activity. Adequate Se-replacement may reduce the severity of organ failure and infections, but not mortality. However, it is encouraging that in animal studies obvious preventive effect of Se has been found on IBD and chronic inflammation induced colon cancer .
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt. 98. 4032.
authors.forename: Dániel Tamás
authors.initials: DT
authors.lastname: Nagy
authors.forename: Béla
authors.initials: B
authors.lastname: Fülesdi
authors.forename: Judit
authors.initials: J
authors.lastname: Hallay
mesh_terms: D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism* / Q000494:pharmacology; D014131:Trace Elements / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005765:Gastrointestinal Agents; D014131:Trace Elements; D005979:Glutathione Peroxidase; D012643:Selenium
keywords: Crohn-betegség; Crohn’s disease; IBD; glutathione peroxidase; glutation-peroxidáz; gyulladásos bélbetegség; selenium; szelén