title: Genetic variations of the FCER2 gene and asthma susceptibility in north Indian children: a case-control study.
abstract: OBJECTIVE
  The findings showed that the low-affinity IgE receptor plays a pivotal role in allergic immune response and it is a pharmacogenetic predictor in asthma disease. This study aims to investigate the association of genetic variations: rs28364072 and rs7249320 with asthma and its severity in north Indian children.
  
  
  METHODS
  Case-control-based genetic association study was performed among 550 children.
  
  
  RESULTS
  Statistical analysis demonstrated significant association between asthma and genotypes frequency of both the SNPs.
  
  
  CONCLUSIONS
  Our data indicate that the studied variations are strongly associated with asthma susceptibility and might be risk factor among north Indian asthmatic children.
authors.affiliation: Department of Paediatrics & Translational Medicine Unit, King George's Medical University , Lucknow, Uttar Pradesh , India and.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Sharma
authors.forename: Pratibha
authors.initials: P
authors.lastname: Dixit
authors.forename: Shally
authors.initials: S
authors.lastname: Awasthi
authors.forename: Shubha R
authors.initials: SR
authors.lastname: Phadke
mesh_terms: D001249:Asthma / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007194:India; D037181:Lectins, C-Type / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017455:Receptors, IgE / Q000235:genetics*; D013147:Spirometry
chemical_list: D017931:DNA Primers; C546930:FCER2 protein, human; D037181:Lectins, C-Type; D017455:Receptors, IgE; D007073:Immunoglobulin E