title: Subcortical origins of human and monkey neocortical interneurons.
abstract: Cortical GABAergic inhibitory interneurons have crucial roles in the development and function of the cerebral cortex. In rodents, nearly all neocortical interneurons are generated from the subcortical ganglionic eminences. In humans and nonhuman primates, however, the developmental origin of neocortical GABAergic interneurons remains unclear. Here we show that the expression patterns of several key transcription factors in the developing primate telencephalon are very similar to those in rodents, delineating the three main subcortical progenitor domains (the medial, lateral and caudal ganglionic eminences) and the interneurons tangentially migrating from them. On the basis of the continuity of Sox6, COUP-TFII and Sp8 transcription factor expression and evidence from cell migration and cell fate analyses, we propose that the majority of primate neocortical GABAergic interneurons originate from ganglionic eminences of the ventral telencephalon. Our findings reveal that the mammalian neocortex shares basic rules for interneuron development, substantially reshaping our understanding of the origin and classification of primate neocortical interneurons.
authors.affiliation: 1] Institutes of Brain Science, Fudan University, Shanghai, China. [2] State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. [3].
authors.forename: Tong
authors.initials: T
authors.lastname: Ma
authors.forename: Congmin
authors.initials: C
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Miao
authors.initials: M
authors.lastname: Tian
authors.forename: Qiangqiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jiwen
authors.initials: J
authors.lastname: Li
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Liu
authors.forename: Yuqun
authors.initials: Y
authors.lastname: Cai
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: You
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Kenneth
authors.initials: K
authors.lastname: Campbell
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: John L
authors.initials: JL
authors.lastname: Rubenstein
authors.forename: Zhengang
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007395:Interneurons / Q000145:classification / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D019579:Neocortex / Q000166:cytology* / Q000196:embryology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009924:Organ Culture Techniques; D014157:Transcription Factors / Q000378:metabolism; D014162:Transfection; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D049452:Green Fluorescent Proteins; D005680:gamma-Aminobutyric Acid; D001973:Bromodeoxyuridine