title: [Case of prostate cancer associated with bisphosphonate-related osteonecrosis of the jaw followed by retropharyngeal abscess].
abstract: A 67-year-old man with castration-resistant prostate cancer associated with multiple bone metastases had been treated with zoledronic acid and docetaxel. Although there was no evidence of damage around the right lower jaw bone, the patient complained of pain in May 2011, which worsened during the next 2 weeks and was followed by difficulty with breathing. Computed tomographic (CT) findings of the cervical area showed swelling of the cervical tissue with air and tightening of the trachea, suggesting cellulitis caused by gas gangrene. He was intubated and treated with antibiotics. On the 12th hospital day, CT scan revealed a pharyngeal abscess and we performed a drainage operation. On the 20th hospital day, bone of the intraoral lower jaw was exposed, revealing that the infection was caused by osteonecrosis. Additional CT findings showed the abscess extending to the mediastinum and multiple liver metastases. Although antibiotic therapy was continued, the patient died of liver failure on the 61st day.
authors.affiliation: The Department of Urology,Osaka Koseinenkin Hospital.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Soda
authors.forename: Ryo
authors.initials: R
authors.lastname: Fukumoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Daizo
authors.initials: D
authors.lastname: Oka
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Takuo
authors.initials: T
authors.lastname: Koide
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000009:adverse effects; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology*; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D000077143:Docetaxel; D004322:Drainage; D017809:Fatal Outcome; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D007568:Jaw; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017703:Retropharyngeal Abscess / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D043823:Taxoids / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D000077211:Zoledronic Acid
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D043823:Taxoids; D000077143:Docetaxel; D000077211:Zoledronic Acid