title: Fetal thrombotic vasculopathy and perinatal thrombosis: should all placentas be examined?
abstract: OBJECTIVE
  Numerous fetal placenta vascular lesions seem to be a predisposing condition for some types of perinatal disease. Placental disease and newborn thromboses might be both manifestations of the same underlying disorder. Objective of this study is to describe pathological lesions of the placenta in newborns with perinatal thrombosis.
  
  
  METHODS
  We present retrospective data review and analysis regarding neonates admitted at our neonatal intensive care unit and diagnosed with an episode of thromboembolic events (TE) in the period from 2009 to 2013; among them we report three cases of perinatal thrombosis in newborns whose placentas demonstrated fetal thrombotic vasculopathy (FTV).
  
  
  RESULTS
  In all the three cases a prothrombotic maternal condition was found, and in one patient a maternal infection with chorioamnionitis; the histological examination of placenta, required soon after birth for maternal pathological conditions, was important in confirming and explaining the clinical diagnosis of neonatal thrombosis and for the management of future pregnancies.
  
  
  CONCLUSIONS
  It is proposed that placenta of newborns with TE in first days of life should always be examined, for its association with FTV and thus the storage of placentas for a week after birth should be routinely implemented.
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Magnetti
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Bagna
authors.affiliation: Patologia materna e fetale, Servizio Anatomia Patologica, Presidio OIRM Sant'Anna, Città della Scienza e della Salute, Torino, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Botta
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Viano
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Dorati
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Melissa
authors.initials: M
authors.lastname: Raia
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bertino
authors.affiliation: Dipartimento di Scienze della Sanità Pubblica e Pediatrica, Università degli Studi di Torino, Torino, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Saracco
mesh_terms: D002821:Chorioamnionitis / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008297:Male; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000473:pathology*; D012189:Retrospective Studies; D013923:Thromboembolism / Q000473:pathology*; D019851:Thrombophilia / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology*; D014652:Vascular Diseases / Q000473:pathology