title: Targeted theranostic nanoparticles: receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery.
abstract: Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.
authors.affiliation: Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon, 305-764, Republic of Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Doo-Yeol
authors.initials: DY
authors.lastname: Choi
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Cho
authors.forename: Kyoung Eun
authors.initials: KE
authors.lastname: Park
authors.forename: Seon-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Seong
authors.initials: S
authors.lastname: Hun Cho
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Hong
authors.forename: Yong Taik
authors.initials: YT
authors.lastname: Lim
mesh_terms: D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D016503:Drug Delivery Systems; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057054:Molecular Imaging; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D011956:Receptors, Cell Surface
keywords: cancer cells; fluorescence; hydrophobicity; polymeric nanoparticles; theranosis