title: Clinical insights from adiponectin analysis in breast cancer patients reveal its anti-inflammatory properties in non-obese women.
abstract: Adiponectin is a cytokine reported as a determinant of poor prognosis in women with breast cancer. However, because data regarding its role in breast cancer have been obtained primarily from studies employing overweight or obese women, the adiponectin profile in non-obese women is poorly understood. In this study, we determined adiponectin levels in plasma from non-obese women with breast cancer and investigated a possible correlation with systemic inflammatory status. We determined the plasma adiponectin levels as well as biochemical and oxidative stress parameters in 80 women. Our results revealed that plasma adiponectin levels were affected by chemotherapy, estrogen receptor status, and disease progression. Adiponectin was positively correlated with antioxidant levels, without affecting either the metastatic behavior of disease or patient outcome. These findings highlight adiponectin as a novel player in the endocrine signaling that modulates the oxidative inflammatory response in human breast cancer, and contribute to the understanding of the role of adiponectin in pathological conditions in non-obese women.
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil. Electronic address: carolpanis@sercomtel.com.br.
authors.forename: C
authors.initials: C
authors.lastname: Panis
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: A C S A
authors.initials: ACSA
authors.lastname: Herrera
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: A M F
authors.initials: AMF
authors.lastname: Aranome
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: V J
authors.initials: VJ
authors.lastname: Victorino
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: P L
authors.initials: PL
authors.lastname: Michelleti
authors.affiliation: Universitary Hospital, Department of Pharmacy, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: H K
authors.initials: HK
authors.lastname: Morimoto
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: A L
authors.initials: AL
authors.lastname: Cecchini
authors.affiliation: Universitary Hospital, Department of Pharmacy, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: A N C
authors.initials: ANC
authors.lastname: Simão
authors.affiliation: Laboratory of Physiopathology and Free Radicals, Department of General Pathology, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Cecchini
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity; D018709:Statistics, Nonparametric
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents
keywords: Adiponectin; Breast cancer; Inflammation; Oxidative stress