title: Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function.
abstract: We investigated the association between arginine-stimulated glucagon secretion (AUCIRG) and several parameters of glycaemic variability in 12 patients with type 1 diabetes without residual beta-cell function. AUCIRG positively correlated with the SD and mean amplitude of glycaemic excursions, thus glucagon might contribute to glycaemic instability, independent of endogenous insulin.
authors.affiliation: Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Bessho
authors.forename: Yuko
authors.initials: Y
authors.lastname: Murase-Mishiba
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tsutsumi
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Haseda
authors.forename: Akihisa
authors.initials: A
authors.lastname: Imagawa
authors.forename: Jungo
authors.initials: J
authors.lastname: Terasaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000097:blood*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005934:Glucagon
keywords: Glucagon; Glycaemic instability; Type 1 diabetes