title: Poly(N-vinyl-2-pyrrolidone-co-vinyl alcohol), a versatile amphiphilic polymeric scaffold for multivalent probes.
abstract: A convenient scaffold based on poly(N-vinyl-2-pyrrolidone-co-vinyl alcohol) is proposed for presenting ligands in multivalent format. This amphiphilic polymer supports synthesis of conjugates in both organic and aqueous media, permits enzymatic processing of the ligand precursor, and, finally, offers a choice of formats for evaluation of biological activity either as a soluble inhibitor or as a capture reagent after deposition on a hydrophobic surface or standard microtiter plates.
authors.affiliation: Alberta Glycomics Centre, Department of Chemistry, and Department of Chemical and Materials Engineering, University of Alberta , Edmonton Alberta, Canada.
authors.forename: Pavel I
authors.initials: PI
authors.lastname: Kitov
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kotsuchibashi
authors.forename: Eugenia
authors.initials: E
authors.lastname: Paszkiewicz
authors.forename: Dennis
authors.initials: D
authors.lastname: Wilhelm
authors.forename: Ravin
authors.initials: R
authors.lastname: Narain
authors.forename: David R
authors.initials: DR
authors.lastname: Bundle
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D008024:Ligands; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D011142:Polyvinyl Alcohol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011205:Povidone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D022622:Shiga Toxin 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D008024:Ligands; D015335:Molecular Probes; D022622:Shiga Toxin 1; D013501:Surface-Active Agents; C050762:poly(vinyl alcohol-co-N-vinyl-2-pyrrolidone); D011142:Polyvinyl Alcohol; D011205:Povidone