title: Fields of effects of 2 commercial preparations of botulinum toxin type A at equal labeled unit doses: a double-blind randomized trial.
abstract: OBJECTIVE
  This article provides new data on a controversial issue, the influence of doses on the diffusion characteristics of 2 botulinum toxins type A. OBJECTIVE To assess the fields of effect of abobotulinumtoxinA and onabotulinumtoxinA at the same labeled unit dose (1:1 U) comparing sweat gland and muscle activity.
  
  
  METHODS
  A prospective, single-center, randomized, double-blind study was conducted at the Brazilian Center for Studies in Dermatology in Porto Alegre, Brazil. The participants included 19 women.
  
  
  METHODS
  Each patient received 2 U of abobotulinumtoxinA on one side of the forehead and 2 U of onabotulinumtoxinA on the other side.
  
  
  METHODS
  Horizontal and vertical diameter and area of the fields of anhidrotic effect, the amplitude of evoked compound muscle action potentials, and the 4-point validated Wrinkle Severity Scale were assessed at 28 days.
  
  
  RESULTS
  The horizontal and vertical diameters of the fields of effect and the areas were significantly larger for onabotulinumtoxinA than those obtained for abobotulinumtoxinA. There were no significant differences between the products in the Wrinkle Severity Scale scores and Evoked Compound Muscle Action Potentials. OnabotulinumtoxinA had significantly more diffusion than abobotulinumtoxinA when isovolumetric injections of the same labeled unit dose of the products were injected. CONCLUSIONS AND RELEVANCE Although many studies state that diffusion is product dependent and abobotulinumtoxinA diffuses more than onabotulinumtoxinA, findings from the present study confirm that diffusion is dose dependent and the more potent dose tested diffuses more. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT01732809.
authors.affiliation: Cosmetic Dermatology, Department of Dermatology, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil 2Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil.
authors.forename: Doris
authors.initials: D
authors.lastname: Hexsel
authors.affiliation: Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil.
authors.forename: Camile
authors.initials: C
authors.lastname: Hexsel
authors.affiliation: Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Siega
authors.affiliation: Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Schilling-Souza
authors.affiliation: Department of Neurology and Neurosurgery, Hospital Moinhos de Vento, Porto Alegre, Brazil.
authors.forename: Francisco Telechea
authors.initials: FT
authors.lastname: Rotta
authors.affiliation: Brazilian Center for Studies in Dermatology, Porto Alegre, Brazil4Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Ticiana C
authors.initials: TC
authors.lastname: Rodrigues
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001938:Brazil; D003357:Cosmetic Techniques; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005546:Forehead; D006801:Humans; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D015595:Skin Aging / Q000187:drug effects*; D013545:Sweat Glands / Q000187:drug effects / Q000378:metabolism
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA