title: Targeted photochemotherapy in alopecia areata.
abstract: OBJECTIVE
  Alopecia areata (AA) is a common cause of localized non-scarring alopecia. Usage of targeted UVA after the topical application of 8-methoxypsoralen (8-MOP) is one of the rising treatment modalities for AA. Our aim was to assess the efficacy and safety of topical 8-MOP plus targeted UVA phototherapy in the treatment of patchy AA.
  
  
  METHODS
  Seven patchy AA patients were treated by topical 8-MOP application to the lesions followed by UVA irradiation 3 times a week, with 15 to 24 sessions in total. At the end of the treatment all patients were evaluated for response on a four-point scale (0 = no hair, 1 = white vellus hair, 2 = regrowth cosmetically acceptable for the patient, 3 = complete hair growth).
  
  
  RESULTS
  The mean cumulative UVA dose was from 7.5 to 39.6 J/cm(2) . For all 7 patients, average response score was calculated as 2, which means cosmetically acceptable regrowth.
  
  
  CONCLUSIONS
  Targeted UVA phototherapy combined with topical 8-MOP may be an effective and safe alternative treatment protocol for patchy AA, which should be kept in mind in order to choose the best for the patient, especially for patients incompatible with other treatments that are systemic and invasive.
authors.affiliation: Department of Dermatology, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Gürol
authors.initials: G
authors.lastname: Açıkgöz
authors.forename: Hakan
authors.initials: H
authors.lastname: Yeşil
authors.forename: Ercan
authors.initials: E
authors.lastname: Çalışkan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tunca
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akar
mesh_terms: D000506:Alopecia Areata / Q000188:drug therapy* / Q000473:pathology; D011564:Furocoumarins / Q000008:administration & dosage*; D006801:Humans; D010778:Photochemotherapy; D012189:Retrospective Studies
chemical_list: D011564:Furocoumarins; C051039:8-methylpsoralen
keywords: alopecia areata; photochemotherapy; targeted