title: Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference.
abstract: Over the last decade there has been considerable progress in the discovery and development of biomarkers of kidney disease, and several have now been evaluated in different clinical settings. Although there is a growing literature on the performance of various biomarkers in clinical studies, there is limited information on how these biomarkers would be utilized by clinicians to manage patients with acute kidney injury (AKI). Recognizing this gap in knowledge, we convened the 10th Acute Dialysis Quality Initiative meeting to review the literature on biomarkers in AKI and their application in clinical practice. We asked an international group of experts to assess four broad areas for biomarker utilization for AKI: risk assessment, diagnosis, and staging; differential diagnosis; prognosis and management; and novel physiological techniques including imaging. This article provides a summary of the key findings and recommendations of the group, to equip clinicians to effectively use biomarkers in AKI.
authors.affiliation: Department of Medicine, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Murray
authors.affiliation: Department of Medicine, UCSD Medical Center, University of California San Diego, San Diego, California, USA.
authors.forename: Ravindra L
authors.initials: RL
authors.lastname: Mehta
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Shaw
authors.affiliation: Renal Division, St Bortolo Hospital, International Renal Research Institute, Vicenza, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.affiliation: 1] Department of Nephrology, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia [2] Christchurch Kidney Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Endre
authors.affiliation: Department of Critical Care Medicine, School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Kellum
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington, DC, USA.
authors.forename: Lakhmir S
authors.initials: LS
authors.lastname: Chawla
authors.affiliation: 1] Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy [2] International Renal Research Institute (IRRIV), Vicenza, Italy.
authors.forename: Dinna
authors.initials: D
authors.lastname: Cruz
authors.affiliation: Department of Intensive Care Adults, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: Can
authors.initials: C
authors.lastname: Ince
authors.affiliation: Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy*; D015415:Biomarkers / Q000032:analysis*; D003627:Data Interpretation, Statistical; D006801:Humans; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers