title: Pallidal deep brain stimulation for dystonia: a case series.
abstract: OBJECTIVE
  Pallidal deep brain stimulation (DBS) is a treatment option for those with early-onset dystonia. However, there are limited data on long-term outcome and treatment complications. The authors report on the short- and long-term effects of pallidal DBS in a cohort of patients with early-onset dystonia.
  
  
  METHODS
  Fourteen consecutive pediatric patients with early-onset dystonia were systematically evaluated and treated. The duration of follow-up ranged from 16 to 84 months.
  
  
  RESULTS
  There were no immediate postoperative complications. At last follow-up, 12 of the 14 patients displayed a significant decline in the Burke-Fahn-Marsden Dystonia Rating Scale motor subscale score, with an average decrease of 62% ± 8.4%. The most common hardware complication was lead fracture (14.3%).
  
  
  CONCLUSIONS
  These data provide further evidence that DBS is a safe and effective treatment for those with earlyonset dystonia.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital; and.
authors.forename: Melita T
authors.initials: MT
authors.lastname: Petrossian
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Paul
authors.forename: Trisha J
authors.initials: TJ
authors.lastname: Multhaupt-Buell
authors.forename: Christine
authors.initials: C
authors.lastname: Eckhardt
authors.forename: Michael T
authors.initials: MT
authors.lastname: Hayes
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Duhaime
authors.forename: Emad N
authors.initials: EN
authors.lastname: Eskandar
authors.forename: Nutan
authors.initials: N
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002408:Catheters, Indwelling; D002648:Child; D002675:Child, Preschool; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000628:therapy*; D020821:Dystonic Disorders / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D038361:Neuronavigation; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome