title: Erythema nodosum as azathioprine hypersensitivity reaction in a patient with bullous pemphigoid.
abstract: A 65-year-old woman with bullous pemphigoid presented with fever and several red-purple nodular subcutaneous lesions on both lower legs 1 week after starting treatment with azathioprine (AZA). Biopsy of a skin nodule was compatible with erythema nodosum (EN) and hypersensitivity reaction to AZA was suspected. AZA was subsequently discontinued, observing complete remission of fever and EN within 2 weeks. This case highlights the importance of recognizing EN as a possible manifestation of hypersensitivity reaction to AZA.
authors.affiliation: Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Virgen de Las Nieves University Hospital, Granada, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Vargas-Hitos
authors.forename: Jose Mario
authors.initials: JM
authors.lastname: Sabio
authors.forename: Jesús
authors.initials: J
authors.lastname: Tercedor
authors.forename: Nuria
authors.initials: N
authors.lastname: Navarrete-Navarrete
authors.forename: Juan
authors.initials: J
authors.lastname: Jiménez-Alonso
keywords: Azathioprine; bullous pemphigoid; erythema nodosum; hypersensitivity syndrome