title: Tubercular arthritis of the elbow joint following olecranon fracture fixation and the role of TGF-beta in its pathogenesis.
abstract: Tuberculosis (TB) occurring after a closed bone fracture in the patient with no history of TB and no evidence of TB infection at the time of initial fracture is a rare entity. We report one such case of a 48-year-old female, who presented in the emergency department with an olecranon fracture which was open reduced and internally fixed with tension band wiring. Patient presented in the outpatient department with serosanguineous discharge at 3 weeks after surgery. The discharge was sent for culture and sensitivity tests, and the patient was managed by antibiotics and daily dressings. There was wound dehiscence and the underlying implant was exposed, which was removed at 12 weeks after surgery. Repeat debridements and dressings continued for 6 months, but the discharge from the wound site continued. X-rays of the elbow performed at 6 months raised the suspicion of TB, which was confirmed by Ziel-Neelsen staining and histopathological examination of the debrided tissue. Following the confirmation, patient was put on antitubercular drugs. The patient responded to antitubercular drug therapy (ATT), the purulent discharge from the wound ceased, and eventually the wound healed after 2 months of starting ATT.
authors.affiliation: Department of Orthopedic Surgery, PGIMER and Dr R.M.L Hospital, New Delhi, India 11001.
authors.forename: Masood
authors.initials: M
authors.lastname: Habib
authors.forename: Yashwant-Singh
authors.initials: YS
authors.lastname: Tanwar
authors.forename: Atin
authors.initials: A
authors.lastname: Jaiswal
authors.forename: Rajender-Kumar
authors.initials: RK
authors.lastname: Arya
mesh_terms: D001170:Arthritis, Infectious / Q000209:etiology*; D004551:Elbow Joint; D005260:Female; D005593:Fracture Fixation, Internal; D006801:Humans; D008875:Middle Aged; D056740:Olecranon Process / Q000293:injuries*; D011183:Postoperative Complications; D053773:Transforming Growth Factor beta1 / Q000502:physiology*; D014394:Tuberculosis, Osteoarticular / Q000209:etiology*
chemical_list: D053773:Transforming Growth Factor beta1