title: Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Krystal
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Benca
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Kilduff
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000627:therapeutic use; D001921:Brain / Q000502:physiology; D001931:Brain Mapping; D002940:Circadian Rhythm / Q000502:physiology; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D017277:Drug Approval; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008550:Melatonin / Q000627:therapeutic use; D009415:Nerve Net / Q000503:physiopathology; D009479:Neuropeptides / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D000068797:Orexins; D011963:Receptors, GABA-A / Q000187:drug effects; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology* / Q000628:therapy; D013493:Suprachiasmatic Nucleus / Q000503:physiopathology; D057170:Translational Research, Biomedical; D014481:United States; D014486:United States Food and Drug Administration; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D006993:Hypnotics and Sedatives; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid; D008550:Melatonin