title: Bis(4-benzyloxyphenyl)iodonium salts as effective precursors for the no-carrier-added radiosynthesis of 4-[¹⁸F]fluorophenol.
abstract: 4-[¹⁸F]Fluorophenol is a very useful intermediate compound for building-up more complex molecules bearing a 4-[¹⁸F]fluorophenoxy moiety. Bis(4-benzyloxyphenyl)iodonium salts proved very effective as labeling precursors for the radiosynthesis of this compound in no-carrier-added form. Starting from the bromide salt and performing the radiofluorination by conventional heating, 4-[¹⁸F]fluorophenol was obtained in an overall RCY of 43 ± 12% while a yield of 52 ± 3% was achieved more reliably starting from the tosylate salt and employing microwave heating.
authors.affiliation: Forschungszentrum Jülich GmbH, Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, 52425 Jülich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Helfer
authors.forename: Johnny
authors.initials: J
authors.lastname: Castillo Meleán
authors.forename: Johannes
authors.initials: J
authors.lastname: Ermert
authors.forename: Angelo
authors.initials: A
authors.lastname: Infantino
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Coenen
keywords: 4-[(18)F]fluorophenol; Diaryliodonium salt; Fluorine-18; Microwave heating; Radiofluorination