title: Photoredox-mediated C-H functionalization and coupling of tertiary aliphatic amines with 2-chloroazoles.
abstract: Herein, conditions for C-H functionalization of tertiary aliphatic amines and their subsequent coupling with a number of 2-chloroazole derivatives are reported. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to α-azole carbinamines commonly found in post-translationally modified peptides.
authors.affiliation: Department of Chemistry, Oklahoma State University , Stillwater, Oklahoma 74078, United States.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Singh
authors.forename: Amandeep
authors.initials: A
authors.lastname: Arora
authors.forename: Jimmie D
authors.initials: JD
authors.lastname: Weaver
mesh_terms: D000588:Amines / Q000737:chemistry*; D001393:Azoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes
chemical_list: D000588:Amines; D001393:Azoles