title: Synthesis and characterization of a calix[4]arene amphiphilie bearing cysteine and uniform Au nanoparticle formation templated by its four cysteine moieties.
abstract: A novel calix[4]arene amphiphilic molecule, denoted by CCaL3, was synthesized and found to form a spherical micelle consisting of 12 molecules at low pH in aqueous solution. Furthermore, uniform Au nanoparticles with 2.0 nm in diameter were synthesized in aqueous solution on the template consisting of the four cysteines of the upper rim of CCaL3. Asymmetric field flow fractionation coupled with light scattering showed that there was no dispersity in the CCaL3 micellar aggregation number. When AuCl4(-) ions were added into the CCaL3 micelle solution, induced circular dichroism (ICD) appeared, indicating appearance of the structural chirality of the CCaL3/AuCl4(-) complex. A combination of electron microscopy and small-angle X-ray scattering showed that helically coiled bilayer sheets were formed upon addition of AuCl4(-). Subsequent reduction with the amine of cysteine moieties led to uniform Au nanoparticles formation with 2.0 nm in diameter on the micellar plate surface. The nanoparticle size was almost equal to the size of cavity constructed by the four cysteines on the calix[4]arene upper rim, indicating that the growth of Au nanoparticles was spatially controlled by the host-guest interaction between the cysteines and Au.
authors.affiliation: Department of Chemistry and Biochemistry, University of Kitakyushu , 1-1 Hibikino, Kitakyushu, Fukuoka 808-0135, Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Fujii
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakurai
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okobira
authors.forename: Noboru
authors.initials: N
authors.lastname: Ohta
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahara
mesh_terms: D047250:Calixarenes / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D008958:Models, Molecular; D008968:Molecular Conformation; D010636:Phenols / Q000737:chemistry*
chemical_list: D008823:Micelles; D010636:Phenols; C121325:calix(4)arene; D047250:Calixarenes; D006046:Gold; D003545:Cysteine