title: Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development.
abstract: The protein kinase C family (PKC) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.
authors.affiliation: Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Lanuza
authors.forename: Manel M
authors.initials: MM
authors.lastname: Santafe
authors.forename: Neus
authors.initials: N
authors.lastname: Garcia
authors.forename: Núria
authors.initials: N
authors.lastname: Besalduch
authors.forename: Marta
authors.initials: M
authors.lastname: Tomàs
authors.forename: Teresa
authors.initials: T
authors.lastname: Obis
authors.forename: Mercedes
authors.initials: M
authors.lastname: Priego
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Nelson
authors.forename: Josep
authors.initials: J
authors.lastname: Tomàs
mesh_terms: D000328:Adult; D006801:Humans; D009469:Neuromuscular Junction / Q000201:enzymology* / Q000502:physiology; D010766:Phosphorylation / Q000502:physiology; D020033:Protein Isoforms / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D020033:Protein Isoforms; D011493:Protein Kinase C
keywords: electrical stimulation; immunofluorescence; isoforms; neuromuscular junction; neurotransmission; protein kinase C; synapse elimination