title: Diagnosis and treatment of Hodgkin's lymphoma: at times a challenge.
abstract: Hodgkin's lymphoma has been traditionally defined as a hematopoietic neoplasm composed of diagnostic Reed-Sternberg cells. More than 70% of the cases involve cervical or supraclavicular lymph nodes. Isolated sub-diaphragmatic lymphadenopathy or organ involvement is rare. We present the case of Hodgkin's lymphoma in a 51 years old female, who presented with obstructive jaundice and lymphadenopathy, empirically treated previously as a case of tuberculosis. Chemotherapy with modified ABVD protocol was given with dose modification according to LFT's. Her liver functions returned to normal levels after the first cycle. The main purpose of reporting the case is to stress definitive diagnosis of the disease before initiating treatment and the modified chemotherapy regimen used in this infrequent presentation of the disease.
authors.affiliation: Department of Oncology, Institute of Nuclear Medicine, Oncology and Radiotherapy (INOR), Abbottabad.
authors.forename: Nadeem Zia
authors.initials: NZ
authors.lastname: Abbasi
authors.forename: Mir
authors.initials: M
authors.lastname: Jalal-ud-Din
authors.forename: Zainab
authors.initials: Z
authors.lastname: Zahur
authors.forename: Amjad Aziz
authors.initials: AA
authors.lastname: Khan
authors.forename: Abdul Samad
authors.initials: AS
authors.lastname: Sheikh
authors.forename: Furqan
authors.initials: F
authors.lastname: Ali
authors.forename: Khalid Hussain
authors.initials: KH
authors.lastname: Memon
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001761:Bleomycin / Q000627:therapeutic use; D003606:Dacarbazine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications; D008206:Lymphatic Diseases / Q000150:complications; D008875:Middle Aged; D017698:Postmenopause; D016896:Treatment Outcome; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin