title: Prevalence of psychiatric disorders in the first trimester of pregnancy and factors associated with current suicide risk.
abstract: This study aimed to describe the prevalence of psychiatric disorders and to identify the factors associated with Current Suicide Risk (CSR) in the first trimester of pregnancy. The Mini-International Neuropsychiatric Interview (M.I.N.I.) was employed to diagnose mental disorders in 239 women enrolled in a prospective cohort in Rio de Janeiro, Brazil. Serum lipids, leptin and socio-economic status were the independent variables. CSR, the dependent variable, was entered as binary (yes/no) variable into crude and adjusted Poisson regression models with robust variances. CSR was found to be the main psychiatric syndrome (18.4%), followed by agoraphobia (17.2%), major depressive disorder (15.1%) and generalized anxiety disorder (10.5%). Women with CSR showed higher mean levels of cholesterol (169.2 vs. 159.2; p=0.017), high density lipoprotein (50.4 vs. 47.7; p=0.031) and low density lipoprotein (102.8 vs. 95.6; p=0.022) when compared to women without CSR. The adjusted regression model showed a higher prevalence ratio (PR) of CSR among pregnant women with generalized anxiety disorder (PR=2.70, 95% CI: 1.36-5.37), with ≥ two parturitions (PR=2.46, 95% CI: 1.22-4.93), and with major depressive disorder (PR=2.11, 95% CI: 1.08-4.12). We have shown that generalized anxiety disorder, major depressive disorder and higher parity are associated with CSR in the first trimester of pregnancy.
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil; Graduate Program in Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, RJ, Brazil.
authors.forename: Dayana Rodrigues
authors.initials: DR
authors.lastname: Farias
authors.forename: Thatiana de Jesus Pereira
authors.initials: Tde J
authors.lastname: Pinto
authors.forename: Marcella Martins Alves
authors.initials: MM
authors.lastname: Teofilo
authors.forename: Ana Amélia Freitas
authors.initials: AA
authors.lastname: Vilela
authors.forename: Juliana dos Santos
authors.initials: Jdos S
authors.lastname: Vaz
authors.forename: Antonio Egidio
authors.initials: AE
authors.lastname: Nardi
authors.forename: Gilberto
authors.initials: G
authors.lastname: Kac
mesh_terms: D000328:Adult; D000379:Agoraphobia; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D001523:Mental Disorders / Q000097:blood / Q000453:epidemiology* / Q000523:psychology; D009483:Neuropsychological Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000523:psychology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D013405:Suicide / Q000523:psychology*; D014754:Violence; D055815:Young Adult
chemical_list: D020738:Leptin; D008055:Lipids
keywords: Agoraphobia; Anxiety; Depressive disorder; Parity; Pregnancy; Suicide; Women