title: Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma.
abstract: Osteosarcoma and chondrosarcoma are the 2 most common malignant bone tumors. This review discusses the clinicopathologic features, recent preclinical developments, and targets currently being or to be validated in the clinic.
authors.affiliation: Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, Leiden RC 2300, The Netherlands.
authors.forename: Jolieke G
authors.initials: JG
authors.lastname: van Oosterwijk
authors.forename: Jakob K
authors.initials: JK
authors.lastname: Anninga
authors.forename: Hans
authors.initials: H
authors.lastname: Gelderblom
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Cleton-Jansen
authors.forename: Judith V M G
authors.initials: JV
authors.lastname: Bovée
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy*; D002813:Chondrosarcoma / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D060787:Neoplasm Grading; D012516:Osteosarcoma / Q000473:pathology* / Q000628:therapy*
keywords: Bone tumor; Chemotherapy; Chondrosarcoma; Hypoxia; Osteosarcoma; Sarcoma; Targeted therapy