title: [Analysis of allergen variation for 3292 patients with allergic rhinitis].
abstract: OBJECTIVE
  To investigate the variation of common allergens in patients with allergic rhinitis in recent 4 years in Tianjin First Center Hospital.
  
  
  METHODS
  The medical records of skin prick test on 3292 patients with allergic rhinitis between 2009 and 2012 were restrospectively analyzed. The changing trend of various allergens in 4 years and distribution differences were compared. The differences of the top 5 allergens in under age group, adult group and different gender group were further analyzed by SPSS 19.0 software.
  
  
  RESULTS
  The positive rate of dermatophagoides farinae was increasing year by year, from 45.1% in 2009 to 66.3% in 2012, and the positive rate of dermatophagoides pteronyssinus increased from 42.0% in 2009 to 58.6% in 2012, the difference was statistically significant (χ(2) value was 68.70, 41.55, all P < 0.01). The positive rate of dermatophagoides farinae and dermatophagoides pteronyssinus in adult group and male group showed significant upward trend year by year (χ(2) value was 75.85, 69.93, 274.25, 42.62, all P < 0.01), but not in adult group and female group. The positive rate of quinoa, mugwort and humulus scandens decreased year by year between 2009 and 2011(χ(2) value was 22.08, 11.64, 203.19, all P < 0.01), but increased again in 2012(χ(2) value was 21.55, 29.38, 12.40, all P < 0.01).
  
  
  CONCLUSIONS
  There is a tendency of change of allergens in patients with AR. This phenominon may be helpful for doctors to choose the type of skin prick liquid.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Center Hospital, Tianjin 300192, China.
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Peng
authors.forename: Jin-mei
authors.initials: JM
authors.lastname: Zhang
authors.forename: Li-sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Shi
authors.forename: Pei-yong
authors.initials: PY
authors.lastname: Sun
authors.forename: Yu-geng
authors.initials: YG
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
mesh_terms: D000485:Allergens / Q000145:classification*; D000818:Animals; D002681:China / Q000453:epidemiology; D040001:Dermatophagoides farinae; D040002:Dermatophagoides pteronyssinus; D005260:Female; D006801:Humans; D008297:Male; D065631:Rhinitis, Allergic / Q000453:epidemiology*; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology; D012882:Skin Tests
chemical_list: D000485:Allergens