title: Postprandial glycemic control conditions in relation to urinary N-acetyl-β-D-glucosaminidase in patients with type 2 diabetes mellitus without low glomerular filtration rate.
abstract: BACKGROUND
  This study assessed the relationship between the serum level of 1,5-anhydroglucitol (1,5-AG), a marker of postprandial hyperglycemia, and the ratio of the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) to creatinine (NAG index) in patients with type 2 diabetes mellitus.
  
  
  METHODS
  This was a cross-sectional study with 153 patients who had an estimated glomerular filtration rate of ≥60 mL/min/1.73 m(2) and no proteinuria and who had never been treated with oral hypoglycemic agents or insulin. On the basis of 1,5-AG levels, the patients were divided into a High 1,5-AG group (>14.0 μg/mL) and a Low 1,5-AG group (≤14.0 μg/mL).
  
  
  RESULTS
  The logarithmically transformed NAG index was significantly higher in the Low 1,5-AG group than in the High 1,5-AG group when all glycated hemoglobin (HbA1c) levels were included. The logarithmically transformed NAG index was lowest in the High 1,5-AG group with an HbA1c level of ≤6.4% and was highest in the Low 1,5-AG group with an HbA1c level of ≥7.5%. Multivariate regression analysis showed that the NAG index had a higher independent association with 1,5-AG than with HbA1c or the fasting plasma glucose level. In all models, multivariate regression analyses showed that the NAG index was correlated with age.
  
  
  CONCLUSIONS
  These results suggest that postprandial hyperglycemia correlates with early renal tubule injury in type 2 diabetes mellitus.
authors.affiliation: 1 Department of Internal Medicine, Division of Geriatric Medicine, Nippon Medical School , Tokyo, Japan .
authors.forename: Motoshi
authors.initials: M
authors.lastname: Ouchi
authors.forename: Kenzo
authors.initials: K
authors.lastname: Oba
authors.forename: Masayuki
authors.initials: M
authors.lastname: Motoyama
authors.forename: Misako
authors.initials: M
authors.lastname: Tsunoda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Junya
authors.initials: J
authors.lastname: Aoyama
authors.forename: Taro
authors.initials: T
authors.lastname: Saigusa
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ishii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yano
authors.forename: Masao
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sekimizu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology / Q000652:urine*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period
chemical_list: D000118:Acetylglucosaminidase; D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human