title: Synthesis, antibacterial, and antiviral evaluation of new heterocycles containing the pyridine moiety.
abstract: A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.
authors.affiliation: Faculty of Science, Synthetic Organic Chemistry Laboratory, Chemistry Department, Ain Shams University, Abbasiya, Cairo, Egypt.
authors.forename: Marwa S
authors.initials: MS
authors.lastname: Salem
authors.forename: Sameh I
authors.initials: SI
authors.lastname: Sakr
authors.forename: Waled M
authors.initials: WM
authors.lastname: El-Senousy
authors.forename: Hassan M F
authors.initials: HM
authors.lastname: Madkour
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D006571:Heterocyclic Compounds; D011725:Pyridines
keywords: 2-Pyridone; Antimicrobial activity; Antivirus activity; Furo[2,3-b]pyridine; Nicotinonitrile