title: Co-delivery of drug and DNA from cationic dual-responsive micelles derived from poly(DMAEMA-co-PPGMA).
abstract: The synthesis and gene transfection efficiency of a series of amphiphilic copolymers with poly(dimethylaminoethyl methacrylate) (PDMAEMA), and poly(propylene glycol methacrylate) (PPGMA) segments is reported. The hydrophobic PPGMA interior allows a cell-sensitizing drug such as paclitaxel to be incorporated while the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency as compared to PEI or PDMAEMA homopolymers.
authors.affiliation: Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore. Electronic address: XianJun_Loh@scholars.a-star.edu.sg.
authors.forename: Xian Jun
authors.initials: XJ
authors.lastname: Loh
authors.forename: Shi Jie
authors.initials: SJ
authors.lastname: Ong
authors.forename: Yin Ting
authors.initials: YT
authors.lastname: Tung
authors.forename: Hoi Teng
authors.initials: HT
authors.lastname: Choo
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000737:chemistry*; D008823:Micelles; D053761:Nanocomposites / Q000737:chemistry; D009757:Nylons / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D014162:Transfection
chemical_list: D004337:Drug Carriers; D008689:Methacrylates; D008823:Micelles; D009757:Nylons; D011108:Polymers; C407037:poly(2-(dimethylamino)ethyl methacrylate); D004247:DNA; D017239:Paclitaxel
keywords: Biomaterials; Gene delivery; Poly(2-(di-methylamino)ethyl methacrylate); Transfection efficiency