title: A new PERKspective on neurodegeneration.
abstract: Targeting stress-induced kinases that regulate protein synthesis may be a new therapeutic strategy for treating neurodegenerative diseases.
authors.affiliation: Department of Clinical Genetics and Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Wiep
authors.initials: W
authors.lastname: Scheper
authors.forename: Jeroen J M
authors.initials: JJ
authors.lastname: Hoozemans
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D000818:Animals; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D009410:Nerve Degeneration / Q000188:drug therapy* / Q000517:prevention & control*; D009473:Neuronal Plasticity / Q000235:genetics*; D017096:Prion Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D056811:Unfolded Protein Response / Q000187:drug effects*; D019892:eIF-2 Kinase / Q000378:metabolism*
chemical_list: C576403:7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine; D007211:Indoles; D019892:eIF-2 Kinase; D000225:Adenine