title: Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis.
abstract: A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.
authors.affiliation: Department of Chemistry, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany.
authors.forename: Arndt W
authors.initials: AW
authors.lastname: Schmidt
authors.forename: Taylor A
authors.initials: TA
authors.lastname: Choi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Theumer
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Knölker
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D002777:Cholestanols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D002777:Cholestanols
keywords: Anti-TB activity; Cholestanols; Inhibition; Steroids; Tuberculosis