title: The road from AKI to CKD: the role of endothelin.
abstract: The incidence of acute kidney injury (AKI) is increasing. It is now widely accepted that patients surviving an episode of AKI have a significant risk of progression to chronic kidney disease (CKD) and even end-stage renal failure. Zager and colleagues describe the role of endothelin-1 (ET-1) in the progression of AKI to CKD and provide a basis for the potential use of ET receptor antagonists as a therapeutic strategy in AKI.
authors.affiliation: Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Dhaun
authors.forename: David J
authors.initials: DJ
authors.lastname: Webb
mesh_terms: D000818:Animals; D018450:Disease Progression; D019332:Endothelin-1 / Q000235:genetics* / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000503:physiopathology*
chemical_list: D019332:Endothelin-1