title: Splenectomy to treat splenic lesions: an analysis of 148 cases at a cancer center.
abstract: OBJECTIVE
  Solid and cystic splenic masses discovered on imaging studies often pose diagnostic and management dilemmas. This study analyses a large series of splenectomies to identify preoperative factors associated with malignant splenic masses.
  
  
  METHODS
  Pathology records at a single institution were reviewed for all splenectomies. Those performed as a component of a larger resection, such as staging or debulking were excluded. Demographic and clinicopathologic factors were obtained. Univariate and multivariate analyses identified factors associated with an increased risk of malignancy.
  
  
  RESULTS
  Between 1986 and 2012, 2,743 patients underwent a splenectomy, 148 of which were performed for lesions identified on imaging. The indications were suspicion of malignancy (120, 81%), growth over time (28, 19%), or symptoms (39, 26%). Resected splenic lesions were malignant in 93 patients (63%); the most common pathologies included ovarian cancer (n = 39), melanoma (n = 14), and colorectal cancer (n = 9). On multivariate analysis of clinicopathologic factors, a previous history of cancer was the only independent predictor of malignancy in the splenic lesion (odds ratio 6.3; 95% CI, 2.32-16.97; P = 0.001).
  
  
  CONCLUSIONS
  While the spleen is an uncommon site of metastatic disease, in patients with a history of cancer, splenic masses selected for resection are frequently malignant.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Amudhan
authors.initials: A
authors.lastname: Pugalenthi
authors.forename: Ciaran
authors.initials: C
authors.lastname: Bradley
authors.forename: Mithat
authors.initials: M
authors.lastname: Gonen
authors.forename: Kinh Gian
authors.initials: KG
authors.lastname: Do
authors.forename: Vivian
authors.initials: V
authors.lastname: Strong
authors.forename: William
authors.initials: W
authors.lastname: Jarnagin
authors.forename: Daniel
authors.initials: D
authors.lastname: Coit
authors.forename: T Peter
authors.initials: TP
authors.lastname: Kingham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology; D002648:Child; D015179:Colorectal Neoplasms / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000556:secondary; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery*; D014057:Tomography, X-Ray Computed
keywords: metastasis; splenectomy; splenic lesion