title: No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
abstract: Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.
authors.affiliation: Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN, 37232, USA, logan.dumitrescu@chgr.mc.vanderbilt.edu.
authors.forename: Logan
authors.initials: L
authors.lastname: Dumitrescu
authors.forename: Cara L
authors.initials: CL
authors.lastname: Carty
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.forename: Lucia A
authors.initials: LA
authors.lastname: Hindorff
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Petra
authors.initials: P
authors.lastname: Bůžková
authors.forename: Fredrick R
authors.initials: FR
authors.lastname: Schumacher
authors.forename: Charles B
authors.initials: CB
authors.lastname: Eaton
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Goodloe
authors.forename: David J
authors.initials: DJ
authors.lastname: Duggan
authors.forename: Jeff
authors.initials: J
authors.lastname: Haessler
authors.forename: Barbara
authors.initials: B
authors.lastname: Cochran
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Iona
authors.initials: I
authors.lastname: Cheng
authors.forename: Karen C
authors.initials: KC
authors.lastname: Johnson
authors.forename: Chris S
authors.initials: CS
authors.lastname: Carlson
authors.forename: Shelly-Anne
authors.initials: SA
authors.lastname: Love
authors.forename: Kristin
authors.initials: K
authors.lastname: Brown-Gentry
authors.forename: Alejandro Q
authors.initials: AQ
authors.lastname: Nato
authors.forename: Miguel
authors.initials: M
authors.lastname: Quibrera
authors.forename: Ralph V
authors.initials: RV
authors.lastname: Shohet
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ambite
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Steven
authors.initials: S
authors.lastname: Buyske
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: Myriam
authors.initials: M
authors.lastname: Fornage
authors.forename: Dana C
authors.initials: DC
authors.lastname: Crawford
mesh_terms: D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D015331:Cohort Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D005828:Genetics, Population; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012907:Smoking / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides