title: Pirfenidone: a potential new therapy for restrictive allograft syndrome?
abstract: This case report describes the evolution of pulmonary function findings (FVC, FEV1 and TLC) and CT features with pirfenidone treatment for restrictive allograft syndrome following lung transplantation. Furthermore, we herein report hypermetabolic activity on (18) F-FDG PET imaging in this setting, which could indicate active fibroproliferation and pleuroparenchymal remodeling. These findings may warrant further investigation.
authors.affiliation: Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Vos
authors.forename: S E
authors.initials: SE
authors.lastname: Verleden
authors.forename: D
authors.initials: D
authors.lastname: Ruttens
authors.forename: E
authors.initials: E
authors.lastname: Vandermeulen
authors.forename: J
authors.initials: J
authors.lastname: Yserbyt
authors.forename: L J
authors.initials: LJ
authors.lastname: Dupont
authors.forename: D E
authors.initials: DE
authors.lastname: Van Raemdonck
authors.forename: N
authors.initials: N
authors.lastname: De Raedt
authors.forename: O
authors.initials: O
authors.lastname: Gheysens
authors.forename: P A
authors.initials: PA
authors.lastname: De Jong
authors.forename: G M
authors.initials: GM
authors.lastname: Verleden
authors.forename: B M
authors.initials: BM
authors.lastname: Vanaudenaerde
mesh_terms: D064591:Allografts; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004646:Emphysema / Q000150:complications / Q000601:surgery*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000150:complications / Q000601:surgery*; D011728:Pyridones / Q000627:therapeutic use*; D019275:Radiopharmaceuticals; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011728:Pyridones; D019275:Radiopharmaceuticals; D014409:Tumor Necrosis Factor-alpha; D019788:Fluorodeoxyglucose F18; C093844:pirfenidone
keywords: Fibrosis; lung transplantation; pirfenidone; restrictive allograft syndrome