title: Network analysis of neurotransmitter related human kinase genes: possible role of SRC, RAF1, PTK2B?
abstract: Previous co-expression analysis of human kinase genes highlighted 119 genes in neurotransmitter-related activity (based on Go:Terms). Using a merged interactome dataset, we analyzed the network of these Neurotransmitter Related Human Kinase Genes. Using the full interactome dataset we extended the network and calculating degrees and closeness centralities we identified SRC, MAPK1, RAF1, PTK2B and AKT1 kinase genes as potentially relevant nodes which did not show relevant activity in the original experimental study. As AKT1 and MAPK1 have already been indicated in various neuronal functions, we hypothesize a potential direct or indirect role for SRC, RAF1, PTK2B genes in neurotransmission and in central nervous system signaling processes.
authors.affiliation: Literatura Medica Network Research Section, Budapest, Hungary. zoltan.brys@lam.hu.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Brys
authors.forename: Andras
authors.initials: A
authors.lastname: Pluhar
authors.forename: Janos Tibor
authors.initials: JT
authors.lastname: Kis
authors.forename: Bela
authors.initials: B
authors.lastname: Buda
authors.forename: Attila
authors.initials: A
authors.lastname: Szabo
mesh_terms: D051418:Focal Adhesion Kinase 2 / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics* / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018377:Neurotransmitter Agents; D051418:Focal Adhesion Kinase 2; C103547:PTK2B protein, human; D016392:Proto-Oncogene Proteins pp60(c-src); D019908:Proto-Oncogene Proteins c-raf