title: Antipsychotic treatment and the occurrence of venous thromboembolism: a 10-year nationwide registry study.
abstract: OBJECTIVE
  To examine the association between antipsychotic use and venous thromboembolism (VTE) in a Taiwan population.
  
  
  METHODS
  We conducted a nested case-control study using the National Health Insurance Research Database in Taiwan. A total of 2,162 cases with VTE (defined as pulmonary embolism and infarction [ICD-9-CM-code: 415.1] or deep vein thrombosis [ICD-9-CM-codes: 451.1x, 451.81, or 453.8]) and 12,966 matched controls were identified from 2001 to 2010. Antipsychotic exposure status was measured, and potential confounding factors were adjusted for in the analyses. Conditional logistic regressions were applied to determine the effect of antipsychotic use on VTE.
  
  
  RESULTS
  Current antipsychotic use was associated with an increased risk for VTE (adjusted odds ratio [AOR] = 1.52; 95% CI, 1.19-1.93). Among current antipsychotic users, new users had a higher risk of VTE (AOR = 3.26; 95% CI, 2.06-5.17), whereas the risk among continuous users was modest but not statistically significant (AOR = 1.18; 95% CI, 0.89-1.56).
  
  
  CONCLUSIONS
  The results demonstrated an increased risk of VTE among subjects with current antipsychotic use. Antipsychotic drugs should be prescribed with caution and attention to the increased risk of VTE. The underlying mechanisms related to the effect of antipsychotics on VTE development warrant further investigation.
authors.affiliation: Department of Psychiatry, Far Eastern Memorial Hospital, Taipei.
authors.forename: Chi-Shin
authors.initials: CS
authors.lastname: Wu
authors.forename: Chao-Cheng
authors.initials: CC
authors.lastname: Lin
authors.forename: Chia-Ming
authors.initials: CM
authors.lastname: Chang
authors.forename: Kuan-Yi
authors.initials: KY
authors.lastname: Wu
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Liang
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Huang
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011618:Psychotic Disorders / Q000188:drug therapy*; D011655:Pulmonary Embolism / Q000139:chemically induced*; D054060:Pulmonary Infarction / Q000139:chemically induced*; D012042:Registries; D018570:Risk Assessment; D013624:Taiwan; D054556:Venous Thromboembolism / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents