title: Prevalence of HPV High-Risk Genotypes in Three Cohorts of Women in Ouagadougou (Burkina Faso).
abstract: The development of cervical cancer is associated with high-risk Human papilloma viruses (HPV-HR). In sub-Saharan Africa cervical cancer is the most common cancer among women and the leading cause of death attributed to malignant tumors. This study aims to identify HPV genotypes within the 30'S and 50'S HPV families found in two previous studies from our laboratory, and to determine the prevalence of twelve HPV-HR genotypes in a population of women in Ouagadougou. The twelve HPV-HR genotypes were determined by real-time multiplex PCR, in 180 samples from the general population and among a group of HIV-1 infected women. The most common genotypes found were HPV-35 (29.4%) and HPV-31 (26.1%) of the 30'S family, and HPV-52 (29.4%) and HPV-58 (20.6%) of the 50'S family. Multiple infections of HPV-HR were observed in 78.03% of infected women. The frequencies of HPV genotypes from the 30'S and 50'S families were higher, while the genotypes HPV-16 and18 were lower among the women in our study.
authors.affiliation: "Pietro Annigoni" Centre for Bio-molecular Research CERBA/LABIOGENE, University of Ouagadougou, 01 BP 364 Ouagadougou 01, Burkina Faso ; University of Parakou, PO Box 123, Republic of Benin.
authors.forename: Theodora M
authors.initials: TM
authors.lastname: Zohoncon
authors.forename: Cyrille
authors.initials: C
authors.lastname: Bisseye
authors.forename: Florencia W
authors.initials: FW
authors.lastname: Djigma
authors.forename: Albert T
authors.initials: AT
authors.lastname: Yonli
authors.forename: Tegwinde R
authors.initials: TR
authors.lastname: Compaore
authors.forename: Tani
authors.initials: T
authors.lastname: Sagna
authors.forename: Djeneba
authors.initials: D
authors.lastname: Ouermi
authors.forename: Charlemagne M R
authors.initials: CM
authors.lastname: Ouédraogo
authors.forename: Virginio
authors.initials: V
authors.lastname: Pietra
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Nikiéma
authors.forename: Simon A
authors.initials: SA
authors.lastname: Akpona
authors.forename: Jacques
authors.initials: J
authors.lastname: Simpore