title: Significance of endangered and threatened plant natural products in the control of human disease.
abstract: One in five of the world's plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50-100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) Proc Natl Acad Sci USA 98(10):5433-5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) Proc Natl Acad Sci USA 108(31):12943-12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant Diplostephium rhododendroides Hieron., as well as other potential drug-producing endangered species in this and other groups.
authors.affiliation: Departments of Pharmacognosy, Medicinal Chemistry, Geology and Geological Engineering, National Center for Natural Products Research, and Departments of Pharmacology, Chemistry, and Biochemistry, School of Pharmacy, The University of Mississippi, University, MS 38677.
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: MinKyun
authors.initials: M
authors.lastname: Na
authors.forename: Joonseok
authors.initials: J
authors.lastname: Oh
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Tami R
authors.initials: TR
authors.lastname: McBrayer
authors.forename: Tony
authors.initials: T
authors.lastname: Whitaker
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Doerksen
authors.forename: David J
authors.initials: DJ
authors.lastname: Newman
authors.forename: Louis G
authors.initials: LG
authors.lastname: Zachos
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D019659:Asteraceae / Q000502:physiology*; D003920:Diabetes Mellitus / Q000188:drug therapy; D056727:Endangered Species; D006801:Humans; D008517:Phytotherapy / Q000379:methods; D010946:Plants, Medicinal / Q000502:physiology*
keywords: diabetes mellitus; endangered plants; hepatitis C virus