title: [The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants].
abstract: The data on the risk factors and etiology of ischemic stroke in 31 infants, aged under 3 years, are summarized. The results of genotyping of blood coagulation and folic acid gene polymorphisms in patients and 83 healthy people are presented. Significant differences were found for -455 G>A FGB (р=0.03) and 807 C>T ITGA2 (р=0,005) polymorphisms. Different gene-gene combinations that can cause hypercoagulation and arterial thrombosis in this age were identified. The most frequent combinations include polymorphisms of genes for FGB, fibrinolysis system and folate cycle enzymes (OR=3,79 and more, p<0.05). A clinical case of ischemic stroke in a girl, aged 10 months, after operated congenital heart malformation is presented.
authors.affiliation: Kafedra nevrologii detskogo vozrasta i neonatologii Ural'skoĭ gosudarstvennoĭ meditsinskoĭ akademii.
authors.forename: O A
authors.initials: OA
authors.lastname: Lvova
authors.forename: V V
authors.initials: VV
authors.lastname: Gusev
authors.forename: N N
authors.initials: NN
authors.lastname: Kuznetsov
authors.forename: D A
authors.initials: DA
authors.lastname: Baranov
authors.forename: E S
authors.initials: ES
authors.lastname: Voroshilina
authors.forename: E A
authors.initials: EA
authors.lastname: Partylova
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D005340:Fibrinogen / Q000235:genetics; D005342:Fibrinolysis / Q000235:genetics*; D006801:Humans; D007223:Infant; D039421:Integrin alpha2 / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D019851:Thrombophilia / Q000151:congenital / Q000175:diagnosis / Q000235:genetics*
chemical_list: C056564:ITGA2B protein, human; D039421:Integrin alpha2; D005340:Fibrinogen; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)