title: Using human induced pluripotent stem cells to treat retinal disease.
abstract: The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK; Ophthalmology, School of Clinical Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
authors.forename: S
authors.initials: S
authors.lastname: Borooah
authors.forename: M J
authors.initials: MJ
authors.lastname: Phillips
authors.forename: B
authors.initials: B
authors.lastname: Bilican
authors.forename: A F
authors.initials: AF
authors.lastname: Wright
authors.forename: I
authors.initials: I
authors.lastname: Wilmut
authors.forename: S
authors.initials: S
authors.lastname: Chandran
authors.forename: D
authors.initials: D
authors.lastname: Gamm
authors.forename: B
authors.initials: B
authors.lastname: Dhillon
mesh_terms: D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation*; D008954:Models, Biological; D044968:Regenerative Medicine / Q000639:trends; D012164:Retinal Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends
keywords: Pluripotent; Reprogramming; Retina; Stem cells; iPS