title: Change of hs-CRP, sVCAM-1, NT-proBNP levels in patients with pregnancy-induced hypertension after therapy with magnesium sulfate and nifedipine.
abstract: OBJECTIVE
  To investigate the change of the hs-CRP, sVCAM-1, NT-proBNP levels of the patients with pregnancy-induced hypertension (PIH) syndrome.
  
  
  METHODS
  A total of 200 patients with PIH were divided into mild, moderate and severe group, and 50 healthy pregnancy patients served as the control group. The serum sVCAM-1 levels were detected by enzyme-linked immunosorbent assay, hs-CRP were detected by immunity transmission turbidity, and NT-proBNP levels were determined by the colloidal gold method. Patients were treated with magnesium sulfate and nifedipine and the contrastive analysis was performed before and after treatment. And the pathological changes in placental of PIH patients were detected by hematoxylin-eosin staining at the same time.
  
  
  RESULTS
  The hs-CRP, sVCAM-1, NT-proBNP levels of patients in the mild, moderate and severe PIH group were significantly higher than that in the control group (P<0.05). The hs-CRP, sVCAM-1, NT-proBNP levels in the severe group were significantly higher than the mild group and the moderate group, the difference was statistically significant (P<0.05). The hs-CRP, sVCAM-1, NT-proBNP of the moderate group were significantly higher than the mild group (P<0.05). There was a positive correlation between hs-CRP, sVCAM-1, NT-proBNP expression levels and the degree of the PIH. The expression of hs-CRP, sVCAM-1, NT-proBNP levels of the moderate and the severe group were significantly decreased (P<0.05). The number of placental villi and interstitial blood vessel in the moderate and severe PIH group were significantly less than the control group (P<0.05).
  
  
  CONCLUSIONS
  The increased levels of serum hs-CRP, sVCAM-1, NT-proBNP may be involved in the process of vascular endothelial cell injury of the PIH, and the hs-CRP, sVCAM-1, NT-proBNP can be used as the auxiliary index for diagnosis of PIH and determination of PIH severity.
authors.affiliation: Affiliated Hospital of Binzhou Medical College, Binzhou 256600, Shandong Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Ying-Qian
authors.initials: YQ
authors.lastname: Huo
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Yao
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Wei
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Wang
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009543:Nifedipine / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000097:blood*; D010920:Placenta; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012720:Severity of Illness Index; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D002121:Calcium Channel Blockers; D010446:Peptide Fragments; D019010:Vascular Cell Adhesion Molecule-1; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D008278:Magnesium Sulfate; D002097:C-Reactive Protein; D009543:Nifedipine
keywords: Amino–terminal pro-brain natriuretic peptide; Pregnancy–induced hypertension; Soluble vascular cell adhesion molecule–1; Ultra–sensitivity C–reactive protein