title: The performance of routine computed tomography for the detection of colorectal cancer.
abstract: BACKGROUND
  Although colonoscopy and computed tomography (CT) colonography in expert hands are the most sensitive investigations for colorectal cancer, some patients may not tolerate the necessary bowel preparation and insufflation of gas into the colon. We assessed the performance of unprepared contrast CT for the detection of colorectal cancer.
  
  
  METHODS
  A retrospective review was undertaken of all patients who had contrast CT of the abdomen and pelvis and then went on to have colonoscopy at our institutions between 2007 and 2010.
  
  
  RESULTS
  Overall, 96 patients were identified as having had CT prior to colonoscopy. The sensitivity of CT in detecting colorectal cancer was 100% (95% confidence interval [CI]: 19.8-100%) and the specificity was 95.7% (95% CI: 88.8-98.6%). The positive predictive value was 33.3% (95% CI: 6.0-75.9%) and the negative predictive value was 100% (95% CI: 94.8-100%).
  
  
  CONCLUSIONS
  Non-targeted CT that is negative for colorectal malignancy is usually reassuring but the decision for further investigations should be made on a case-by-case basis, taking into account of the likelihood of underlying colorectal malignancy and the underlying co-morbidities of the patient. However, video colonoscopy is usually necessary to assess positive CT findings.
authors.affiliation: NHS Lothian, UK.
authors.forename: H
authors.initials: H
authors.lastname: Colvin
authors.forename: A
authors.initials: A
authors.lastname: Lukram
authors.forename: I
authors.initials: I
authors.lastname: Sohail
authors.forename: K T
authors.initials: KT
authors.lastname: Chung
authors.forename: E
authors.initials: E
authors.lastname: Jehangir
authors.forename: J
authors.initials: J
authors.lastname: Berry
authors.forename: H
authors.initials: H
authors.lastname: Babu
authors.forename: F
authors.initials: F
authors.lastname: Hinson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023881:Colonography, Computed Tomographic / Q000592:standards; D003113:Colonoscopy / Q000592:standards; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000592:standards; D014057:Tomography, X-Ray Computed / Q000592:standards*; D055815:Young Adult