title: Maternal floor infarction: management of an underrecognized pathology.
abstract: Maternal floor infarction is a relatively rare condition characterized clinically by severe early onset fetal growth restriction with features of uteroplacental insufficiency. It has a very high recurrence rate and carries a significant risk or fetal demise. Pathological characteristics include massive and diffuse fibrin deposition along the decidua basalis and the perivillous space of the basal plate. We present a case of recurrent maternal floor infarction and propose diagnostic clues as well as potential therapeutic options.
authors.affiliation: Department of OBS GYN, Division of Maternal-Fetal Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Nada
authors.initials: N
authors.lastname: Al-Sahan
authors.forename: David
authors.initials: D
authors.lastname: Grynspan
authors.forename: Peter
authors.initials: P
authors.lastname: von Dadelszen
authors.forename: Andrée
authors.initials: A
authors.lastname: Gruslin
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000517:prevention & control; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D007238:Infarction / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D010920:Placenta / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D021041:Placental Circulation; D010927:Placental Insufficiency / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D011247:Pregnancy; D055502:Secondary Prevention; D012720:Severity of Illness Index; D015854:Up-Regulation; D014591:Uterine Diseases / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy
chemical_list: D005337:Fibrin
keywords: diagnosis; elevated α-fetoprotein; fetal growth restriction; fibrin deposition; globular placenta; maternal floor infarction; therapy