title: Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer.
abstract: OBJECTIVE
  To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis.
  
  
  METHODS
  An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis.
  
  
  RESULTS
  5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs.
  OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity.
  
  
  CONCLUSIONS
  This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.
authors.affiliation: Department of Infection and Liver Diseases, Institution of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, China.
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Shi
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Lin
authors.forename: De-Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Yu-Xiao
authors.initials: YX
authors.lastname: Fang
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Gui-Ling
authors.initials: GL
authors.lastname: Li
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wu
authors.forename: Kai-Fu
authors.initials: KF
authors.lastname: Tang
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; C542543:MIRN196 microRNA, human; D035683:MicroRNAs