title: Information decoding in microscopic biological processes.
abstract: The cellular and intracellular dynamics are intrinsically stochastic and dynamic. However, whole biological system such as a cell or our body can function very robustly and stably even though they are composed of these stochastic reactions. To account for this riddling relation between macroscopic robustness and microscopic stochasticity, I propose a mechanism that information relevant for stable and reliable operation of a biological system is embedded in apparently stochastic and noisy behavior of their components. To show validity of this possibility, I demonstrates that information can actually be decoded from apparently noisy signal when it is processed by an appropriate dynamics derived by Bayes' rule. Next, I investigate biological relevance of this possibility by showing that several intracellular networks can implement this decoding dynamics. Finally, by focusing its dynamical properties, I show the mechanism how the derived dynamics can separate information and noise.
authors.forename: Tetsuya J
authors.initials: TJ
authors.lastname: Kobayashi
mesh_terms: D001499:Bayes Theorem; D001686:Biological Phenomena; D008954:Models, Biological; D013269:Stochastic Processes