title: Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women.
abstract: OBJECTIVE
  DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women.
  
  
  METHODS
  Polymorphism was determined by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method and risk of cervical cancer was evaluated by calculating odds ratios (ORs) and 95% confidence interval (CI) using a multivariate logistic regression analysis.
  
  
  RESULTS
  No association was found between variant forms (AC, AA) of LIGI gene and risk of cervical cancer (OR - 0.8, 95% CI 0.46-1.53 and OR - 1.0, 95% CI 0.51-2.06, respectively). However, increased but statistically non-significant risk of adenocarcinoma was observed for cervical cancer patients having AC (OR - 4.6, 95% CI 0.62-33.82) and AA (OR - 5.0, 95% CI 0.63-39.58) genotypes.
  
  
  CONCLUSIONS
  It can thus be concluded that there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women. Further investigations in larger studies need to be carried out for more analysis.
authors.affiliation: Department of Biotechnology, SGGS College, Chandigarh, India.
authors.forename: S
authors.initials: S
authors.lastname: Kaur
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007194:India; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: C000607892:LIG1 protein, human; D011088:DNA Ligases; D000072481:DNA Ligase ATP