title: List-Barbas-Mannich reaction catalyzed by modularly designed organocatalysts.
abstract: The List-Barbas-Mannich reaction of ethyl (p-methoxyphenylimino)acetate (p-methoxyphenyl = PMP) with unmodified aldehydes or ketones catalyzed by modularly designed organocatalysts (MDOs) that are self-assembled from proline and cinchona alkaloid thioureas (such as a quinidine-derived thiourea) produces the corresponding γ-oxo-α-amino acid derivatives in high yields and excellent stereoselectivities. No solvent is necessary for this reaction. Aldehydes are especially good substrates for this reaction: The reaction takes only a few minutes to yield the corresponding List-Barbas-Mannich products in excellent dr (up to >99:1) and ee values (up to >99% ee).
authors.affiliation: Department of Chemistry, University of Texas at San Antonio , One UTSA Circle, San Antonio, Texas 78249-0698, United States.
authors.forename: Sandun
authors.initials: S
authors.lastname: Perera
authors.forename: Debarshi
authors.initials: D
authors.lastname: Sinha
authors.forename: Nirmal K
authors.initials: NK
authors.lastname: Rana
authors.forename: Van
authors.initials: V
authors.lastname: Trieu-Do
authors.forename: John Cong-Gui
authors.initials: JC
authors.lastname: Zhao