title: [Ante-natal corticosteroids and prevention of respiratory distress in the premature newborn: usefulness of rescue treatment].
abstract: The effectiveness of antenatal corticosteroid therapy for foetal lung maturation in pre-term infants is well known, but there is uncertainty about the time that the treatment remains effective. A descriptive, longitudinal study was conducted to determine whether the need for surfactant administration was determined by the time-lapse between corticosteroids administration and delivery, and when repeating the doses of maternal corticosteroids should be considered. A total of 91 premature infants ≤32 weeks and/or ≤1,500 g (limit 34+6 weeks) whose mothers had received a complete course of corticosteroids were included. In patients at 27-34+6 weeks, we found that the longer the time elapsed between delivery and administration of corticosteroids, most likely were the babies to require treatment with surfactant (P=.027). The resulting ROC curve determined an 8-days cut-off after which repeating a dose of corticosteroids should be assessed.
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España. Electronic address: Olalla.elena.lopez.suarez@sergas.es.
authors.forename: O
authors.initials: O
authors.lastname: López-Suárez
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: C
authors.initials: C
authors.lastname: García-Magán
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: R
authors.initials: R
authors.lastname: Saborido-Fiaño
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Muñuzuri
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: A
authors.initials: A
authors.lastname: Baña-Souto
authors.affiliation: Servicio de Neonatología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: M L
authors.initials: ML
authors.lastname: Couce-Pico
mesh_terms: D001623:Betamethasone / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011295:Prenatal Care; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone
keywords: Antenatal corticosteroids; Back up therapy; Corticoides antenatales; Enfermedad de membrana hialina; Hyaline membrane disease; Prematuridad; Prematurity; Terapia de rescate