title: Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells.
abstract: Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.
authors.affiliation: Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66013 Chieti, Italy; Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Celia
authors.forename: Elena
authors.initials: E
authors.lastname: Trapasso
authors.forename: Marcello
authors.initials: M
authors.lastname: Locatelli
authors.forename: Michele
authors.initials: M
authors.lastname: Navarra
authors.forename: Cinzia Anna
authors.initials: CA
authors.lastname: Ventura
authors.forename: Joy
authors.initials: J
authors.lastname: Wolfram
authors.forename: Maria
authors.initials: M
authors.lastname: Carafa
authors.forename: Valeria Maria
authors.initials: VM
authors.lastname: Morittu
authors.forename: Domenico
authors.initials: D
authors.lastname: Britti
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Marzio
authors.forename: Donatella
authors.initials: D
authors.lastname: Paolino
mesh_terms: D000078223:5-Methoxypsoralen; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002957:Citrus / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008730:Methoxsalen / Q000008:administration & dosage / Q000031:analogs & derivatives; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology; D009822:Oils, Volatile / Q000008:administration & dosage; D010938:Plant Oils / Q000008:administration & dosage*; D012995:Solubility
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008081:Liposomes; D009822:Oils, Volatile; D010938:Plant Oils; C068336:bergamot oil; D000078223:5-Methoxypsoralen; D008730:Methoxsalen
keywords: Bergamot essential oil (BEO); Cancer; Citrus extracts; Liposomes; Natural products; SH-SY5Y human neuroblastoma cells