title: Hydroxyclerodanes from Salvia shannoni.
abstract: Six new hydroxyclerodanes (1-6), named sepulturins A-F, and four known diterpenes were isolated from the leaves of Salvia shannoni. The structures of these compounds were established by extensive analysis of their NMR and MS spectroscopic data. The relative configurations of compounds 1 and 2 were determined by NOESY experiments and were confirmed by single-crystal X-ray diffraction studies. All of the isolated diterpenes possess tertiary OH groups. The structure of infuscatin (7), a clerodane previously isolated from S. infuscata, was revised. Cytotoxic, antiprotozoal, and anti-inflammatory activities of these compounds were evaluated.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México City, Mexico.
authors.forename: Elihú
authors.initials: E
authors.lastname: Bautista
authors.forename: Alfredo
authors.initials: A
authors.lastname: Toscano
authors.forename: Fernando
authors.initials: F
authors.lastname: Calzada
authors.forename: Eduardo
authors.initials: E
authors.lastname: Díaz
authors.forename: Lilian
authors.initials: L
authors.lastname: Yépez-Mulia
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ortega
mesh_terms: D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008800:Mexico; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; C585299:infuscatin