title: [Functional and morphological correlations in macular hole surgery].
abstract: BACKGROUND
  The purpose of this study is to establish the correlation between functional and morphological aspects before and 12 months after macular hole surgery.
  
  
  METHODS
  In this prospective, interventional, consecutive study 16 eyes of 16 patients were included. All eyes received a successful transconjunctival 23-gauge vitrectomy with ILM peeling after initial diagnosis and maximum duration of symptoms of two months. Preoperatively and 3, 6 and 12 months postoperatively determinations of best-corrected visual acuity (logMAR), a 10° microperimetry (MP-1) and a spectral-domain based optical coherence tomography (SD-OCT) examination were performed. The photoreceptor layer (inner and outer segment, IS/OS) was evaluated based on SD-OCT images and correlated with data assessed by microperimetry analysis in the foveal and parafoveal region.
  
  
  RESULTS
  After three months a stabilisation of BCVA with regeneration of the IS/OS line, an improvement of the fixation behaviour and the macular sensitivity could be observed. A significant restitution of the IS/OS line was observed after 12 months. Best corrected visual acuity, mean overall macular sensitivity and fixation improved significantly within the twelve month observation period (p < 0.05). Comparison of patients with at least two lines of visual acuity gain with patients having less than two lines of visual acuity gain 12 months after surgery showed no statistically significant difference in regeneration of the IS/OS integrity in the fovea (p = 0.433), but a difference was seen in the parafoveal region. A postoperative visual acuity gain of at least two lines was significantly more often seen in eyes with postoperative continuous IS/OS line in the parafoveal sectors compared to eyes with persistent IS/OS defects (p < 0.02).
  
  
  CONCLUSIONS
  Correlations of morphological and functional improvements can be observed after successful micro-invasive macular hole surgery. The extent of the preoperative IS/OS defect, particularly in the parafoveal region, is a good predictive parameter for the postoperatively obtained macular sensitivity. The prediction of the postoperative visual acuity should not be made on the basis of a single clinical, anatomic finding.
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: W J
authors.initials: WJ
authors.lastname: Mayer
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: L
authors.initials: L
authors.lastname: Reznicek
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: A S
authors.initials: AS
authors.lastname: Neubauer
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: A
authors.initials: A
authors.lastname: Wolf
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: A
authors.initials: A
authors.lastname: Kampik
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, München.
authors.forename: C
authors.initials: C
authors.lastname: Haritoglou
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012167:Retinal Perforations / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D013223:Statistics as Topic; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity; D014821:Vitrectomy