title: Noninvasive 3D pressure calculation from PC-MRI via non-iterative harmonics-based orthogonal projection: constant flow experiment.
abstract: Use of phase-contrast (PC) MRI in assessment of hemodynamics has significant clinical importance. In this paper we develop a novel approach to determination of hemodynamic pressures. 3D gradients of pressure obtained from Navier-Stokes equation are expanded into a series of orthogonal basis functions, and are subsequently projected onto an integrable subspace. Before the projection step however, a scheme is devised to eliminate the discontinuity at the vessel and image boundaries. In terms of the computation time, the proposed approach significantly improves on previous iterative methods for pressure calculations. The method has been validated using computational fluid dynamic simulations and in-vitro MRI studies of stenotic flows.
authors.forename: M J
authors.initials: MJ
authors.lastname: Negahdar
authors.forename: Mo
authors.initials: M
authors.lastname: Kadbi
authors.forename: J
authors.initials: J
authors.lastname: Cha
authors.forename: J
authors.initials: J
authors.lastname: Cebral
authors.forename: A
authors.initials: A
authors.lastname: Amini
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008858:Microscopy, Phase-Contrast; D016011:Normal Distribution; D019047:Phantoms, Imaging; D016012:Poisson Distribution; D011312:Pressure; D015203:Reproducibility of Results; D012984:Software