title: Preparation of biocompatible aggregation-induced emission homopolymeric nanoparticles for cell imaging.
abstract: A series of new homopolymers with various degrees of polymerization derived from vinyl tetraphenylethene, that is, poly[2-(4-vinylphenyl)ethene-1,1,2-triyl)tribenzene] homopolymers, is synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. The homopolymers exhibit a significant aggregation-induced emission (AIE) effect and an ability to assemble themselves into AIE polymer nanoparticles (NPs) during precipitation in a water/tetrahydrofuran (THF) mixture. The NPs also exhibit good dispersibility, stability, and biocompatibility. The AIE polymer NPs are used in imaging studies of HeLa cells.
authors.affiliation: PCFM Lab, DSAPM Lab, KLGHEI of Environment and Energy Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Ma
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Ling
authors.forename: Shidang
authors.initials: S
authors.lastname: Xu
authors.forename: Hongni
authors.initials: H
authors.lastname: Zhu
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Xie
authors.initials: X
authors.lastname: Zhou
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Chi
authors.forename: Siwei
authors.initials: S
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jiarui
authors.initials: J
authors.lastname: Xu
mesh_terms: D001672:Biocompatible Materials; D060326:Chemistry Techniques, Synthetic; D005663:Furans; D006367:HeLa Cells; D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D058105:Polymerization
chemical_list: D001672:Biocompatible Materials; D005663:Furans; C018674:tetrahydrofuran
keywords: RAFT polymerization; aggregation-induced emission; cell imaging; nanoparticles