title: Zig Zag versus Top Hat configuration in IntraLase-enabled penetrating keratoplasty.
abstract: OBJECTIVE
  To compare the outcomes with IntraLase-enabled keratoplasty using (IEK) Top Hat (TH) versus Zig Zag (ZZ) configuration.
  
  
  METHODS
  Retrospective comparative series of 24 eyes that underwent TH and 10 eyes that underwent ZZ IEK.
  
  
  RESULTS
  There were no significant differences in LogMar Best-spectacle corrected visual acuity (TH- IEK=0.3; ZZ-IEK=0.18, p=0.18), spherical equivalent (TH-IEK=-3.55±3.7 dioptres (D); ZZ-IEK=-2.69±4.85 D, p=0.60), manifest cylinder (TH- IEK=3.79±2.43 D; ZZ- IEK=4.61±3.29 D, p=0.45), topographic astigmatism (TH-IEK=3.67±2.34 D; ZZ-IEK=4.26±1.1 D, p=0.63), total higher-order aberrations (TH- IEK=8.26±3.53; ZZ-IEK=8.1±4.71, P=0.92), endothelial cell density change from baseline (TH- IEK= -41.55%±15.86; ZZ-IEK=-25.45%±30.66, p=0.22) or time to suture removal in months (TH- IEK=7.48±4.07; ZZ- IEK=6.93±2.71, p=0.75). There was no difference in requirements for astigmatic keratectomy (TH-IEK=54.2%±13; ZZ-IEK=50%±5, OR=1.18) or complications (TH-IEK=25%±6; ZZ-IEK=30%±3, OR=0.78).
  
  
  CONCLUSIONS
  TH-IEK and ZZ-IEK have comparable visual and refractive outcomes, wound healing and endothelial cell counts at 1-year.
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada Departfment of Ophthalmology, Bnai Zion Medical Center, Technion, Haifa, Israel.
authors.forename: Raneen
authors.initials: R
authors.lastname: Shehadeh Mashor
authors.affiliation: Department of Ophthalmology, Rabin Medical Center, Petach, Tiqva, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Bahar
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Dan B
authors.initials: DB
authors.lastname: Rootman
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Nikhil L
authors.initials: NL
authors.lastname: Kumar
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Neera
authors.initials: N
authors.lastname: Singal
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Allan R
authors.initials: AR
authors.lastname: Slomovic
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: David S
authors.initials: DS
authors.lastname: Rootman
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000503:physiopathology; D002452:Cell Count; D003316:Corneal Diseases / Q000503:physiopathology / Q000601:surgery*; D055954:Corneal Endothelial Cell Loss / Q000503:physiopathology; D019781:Corneal Topography; D057108:Corneal Wavefront Aberration / Q000503:physiopathology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D015948:Keratoplasty, Penetrating / Q000379:methods*; D053685:Laser Therapy; D008297:Male; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D013536:Suture Techniques; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
keywords: Cornea