title: Proliferation activity in the adult rat brain following exposure to ionizing radiation.
abstract: BACKGROUND
  The aim of our study was to investigate radiationinduced shortterm effects on the rat forebrain.
  
  
  METHODS
  Adult male Wistar rats received whole body exposure with fractionated doses of gamma rays (a total dose of 3 Gy) and were investigated seven and 14 days later. Immunohistochemistry and confocal microscopy were used to determine proliferating cells derived from anterior subventricular zone (SVZa) and distributed along the subventricular zone olfactory bulb axis (SVZ OB axis). Cell counting was performed in four anatomical parts along the welldefined pathway, known as the rostral migratory stream (RMS) represented by the SVZa, vertical arm, elbow and horizontal arm.
  
  
  RESULTS
  Different rate of cell overdistribution was found in all counted parts through the entire experiment, mostly detectable in the elbow and horizontal arm.
  
  
  CONCLUSIONS
  Results suggested that radiation response of proliferating cells resides the SVZa may a play contributory role in the development of more adverse radiationinduced: late effects.
authors.forename: S
authors.initials: S
authors.lastname: Bálentová
authors.forename: E
authors.initials: E
authors.lastname: Hajtmanová
authors.forename: R
authors.initials: R
authors.lastname: Trylčová
authors.forename: J
authors.initials: J
authors.lastname: Lehotský
authors.forename: M
authors.initials: M
authors.lastname: Adamkov
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000528:radiation effects; D002465:Cell Movement / Q000528:radiation effects; D049109:Cell Proliferation; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016548:Prosencephalon / Q000166:cytology / Q000473:pathology / Q000528:radiation effects*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation
keywords: ionizing radiation - dose fractionation - brain - SVZ-OB axis - Ki-67.