title: Cardiac complications and diabetes in thalassaemia major: a large historical multicentre study.
abstract: The relationship between diabetes mellitus (DM) and cardiac complications has never been systematically studied in thalassaemia major (TM). We evaluated a large retrospective historical cohort of TM to determine whether DM is associated with a higher risk of heart complications. We compared 86 TM patients affected by DM with 709 TM patients without DM consecutively included in the Myocardial Iron Overload in Thalassaemia database where clinical/instrumental data are recorded from birth to the first cardiovascular magnetic resonance (CMR) exam. All of the cardiac events considered were developed after the DM diagnosis. In DM patients versus non-DM patients we found a significantly higher frequency of cardiac complications (46.5% vs. 16.9%, P < 0.0001), heart failure (HF) (30.2% vs. 11.7%, P < 0.0001), hyperkinetic arrhythmias (18.6% vs. 5.5%, P < 0.0001) and myocardial fibrosis assessed by late gadolinium enhancement (29.9% vs. 18.4%, P = 0.008). TM patients with DM had a significantly higher risk of cardiac complications [odds ratio (OR) 2.84, P < 0.0001], HF (OR 2.32, P = 0.003), hyperkinetic arrhythmias (OR 2.21, P = 0.023) and myocardial fibrosis (OR 1.91, P = 0.021), also adjusting for the absence of myocardial iron overload assessed by T2* CMR and for the covariates (age and/or endocrine co-morbidity). In conclusion, DM significantly increases the risk for cardiac complications, HF, hyperkinetic arrhythmias and myocardial fibrosis in TM patients.
authors.affiliation: Cardiovascular MR Unit, Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Pepe
authors.forename: Antonella
authors.initials: A
authors.lastname: Meloni
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Caruso
authors.forename: Liana
authors.initials: L
authors.lastname: Cuccia
authors.forename: Anna
authors.initials: A
authors.lastname: Spasiano
authors.forename: Calogera
authors.initials: C
authors.lastname: Gerardi
authors.forename: Angelo
authors.initials: A
authors.lastname: Zuccarelli
authors.forename: Domenico G
authors.initials: DG
authors.lastname: D'Ascola
authors.forename: Salvatore
authors.initials: S
authors.lastname: Grimaldi
authors.forename: Michele
authors.initials: M
authors.lastname: Santodirocco
authors.forename: Saveria
authors.initials: S
authors.lastname: Campisi
authors.forename: Maria E
authors.initials: ME
authors.lastname: Lai
authors.forename: Basilia
authors.initials: B
authors.lastname: Piraino
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Chiodi
authors.forename: Claudio
authors.initials: C
authors.lastname: Ascioti
authors.forename: Letizia
authors.initials: L
authors.lastname: Gulino
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Positano
authors.forename: Massimo
authors.initials: M
authors.lastname: Lombardi
authors.forename: Maria R
authors.initials: MR
authors.lastname: Gamberini
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D058065:Diabetic Cardiomyopathies / Q000150:complications* / Q000378:metabolism; D005260:Female; D006331:Heart Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019190:Iron Overload / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D017086:beta-Thalassemia / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology
keywords: cardiac complications; cardiovascular magnetic resonance; diabetes mellitus; myocardial iron overload; thalassaemia major