title: Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity.
abstract: OBJECTIVE
  To evaluate the effect of avocado soybean unsaponifiables (ASU) on insulin secretion and insulin sensitivity in patients with obesity.
  
  
  METHODS
  A randomized, double-blind, placebo-controlled, clinical trial was carried out in 14 obese adult volunteers. After random allocation of the intervention, 7 patients received 300 mg of ASU or placebo during a fasting state for 3 months. A metabolic profile including IL-6 and high-sensitivity C-reactive protein (hs-CRP) levels was carried out prior to the intervention. A hyperglycemic-hyperinsulinemic clamp technique was used to assess insulin secretion and insulin sensitivity phases. Mann-Whitney U test and Wilcoxon test were performed for statistical analyses. The study was approved by the local ethics committee of our institution.
  
  
  RESULTS
  At baseline, both groups were similar according to clinical and laboratory characteristics. There was no significant difference in insulin secretion and insulin sensitivity with ASU.
  
  
  CONCLUSIONS
  ASU administration for 3 months did not modify insulin secretion and insulin sensitivity in patients with obesity.
authors.affiliation: Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: Arieh R
authors.initials: AR
authors.lastname: Mercado-Sesma
authors.forename: Claudia
authors.initials: C
authors.lastname: Reynoso-von-Drateln
authors.forename: Aureliano
authors.initials: A
authors.lastname: Moreno-Andrade
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D015850:Interleukin-6 / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism*; D027421:Persea / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*; D018709:Statistics, Nonparametric
chemical_list: D007328:Insulin; D015850:Interleukin-6; D010936:Plant Extracts; D002097:C-Reactive Protein