title: Protective effect of fenspiride on the bronchi in rats with chronic obstructive pulmonary disease.
abstract: We studied the effect of a non-steroidal anti-inflammatory drug fenspiride on contractive activity of bronchial smooth muscles on the model of chronic obstructive pulmonary disease of rats induced by 60-day exposure to nitrogen dioxide. The administration of fenspiride during the acute stage of the disease (day 15) abolished the constricting effect of the pollutant on the bronchial smooth muscles. Dilatation effect of fenspiride in a low dose (0.15 mg/kg) was mediated by its interaction with nerve endings of bronchial capsaicin-sensitive nerve C-fibers. The interaction of drug with receptors of C-fibers prevented neurogenic inflammation, which was confirmed by the absence of structural changes in the lungs typical of this pathology. The broncholytic effect of fenspiride in a high dose (15 mg/kg) was mediated by not only afferent pathways, but also its direct relaxing action on smooth muscle cells. The observed anti-inflammatory and bronchodilatation effect of fenspiride in very low doses can be used for prevention of chronic obstructive pulmonary disease in risk-group patients contacting with aggressive environmental factors.
authors.affiliation: Institute of Pulmonology, I. P. Pavlov St. Petersburg State Medical University; I. P. Pavlov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. osmelena@mail.ru.
authors.forename: N A
authors.initials: NA
authors.lastname: Kuzubova
authors.forename: E S
authors.initials: ES
authors.lastname: Lebedeva
authors.forename: A N
authors.initials: AN
authors.lastname: Fedin
authors.forename: I V
authors.initials: IV
authors.lastname: Dvorakovskaya
authors.forename: O N
authors.initials: ON
authors.lastname: Titova
mesh_terms: D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002211:Capsaicin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy / Q000517:prevention & control; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects; D009585:Nitrogen Dioxide; D011343:Procaine / Q000494:pharmacology; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013141:Spiro Compounds / Q000627:therapeutic use*; D015320:Tachykinins / Q000378:metabolism
chemical_list: D001993:Bronchodilator Agents; D013141:Spiro Compounds; D015320:Tachykinins; D011343:Procaine; D002211:Capsaicin; D009585:Nitrogen Dioxide; C084775:fenspiride