title: Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.
abstract: Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.
authors.affiliation: Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX, 77005, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Coughlin
authors.forename: Jeyarama S
authors.initials: JS
authors.lastname: Ananta
authors.forename: Nanfu
authors.initials: N
authors.lastname: Deng
authors.forename: Irina V
authors.initials: IV
authors.lastname: Larina
authors.forename: Paolo
authors.initials: P
authors.lastname: Decuzzi
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: West
mesh_terms: D000818:Animals; D004220:Disulfides / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006979:Hyperthermia, Induced; D049449:Luminescence; D008546:Melanoma, Experimental / Q000175:diagnosis / Q000473:pathology; D051379:Mice; D064847:Multimodal Imaging; D057145:Nanoshells / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D019047:Phantoms, Imaging; D017785:Photons; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared; D040521:Subcutaneous Tissue / Q000473:pathology; D041623:Tomography, Optical Coherence
chemical_list: D004220:Disulfides; D011092:Polyethylene Glycols; D006046:Gold; D005682:Gadolinium
keywords: X-ray imaging; gold-silica nanoshells; magnetic resonance imaging; optical imaging; photothermal ablation