title: Genetic variants in DNA repair pathways are not associated with disease progression among multiple myeloma patients.
abstract: DNA damage induced by high dose melphalan and autologous transplantation is repaired by the nucleotide excision repair (NER) and base excision repair (BER) pathways. We evaluated the association between single nucleotide polymorphisms (SNPs) (n=311) in the NER and BER pathways and disease progression in 695 multiple myeloma patients who underwent autologous transplantation. None of the SNPs were associated with disease progression. Pathway based analyses showed that the NER pathway had a borderline association with disease progression (p=0.09). These findings suggest that common variation in the NER and BER pathways do not substantially influence disease progression in multiple myeloma patients.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. Electronic address: thya0003@umn.edu.
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.forename: Mukta
authors.initials: M
authors.lastname: Arora
authors.forename: Weihua
authors.initials: W
authors.lastname: Guan
authors.forename: Helene
authors.initials: H
authors.lastname: Barcelo
authors.forename: Scott
authors.initials: S
authors.lastname: Jackson
authors.forename: Shaji
authors.initials: S
authors.lastname: Kumar
authors.forename: Morie
authors.initials: M
authors.lastname: Gertz
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D003131:Combined Modality Therapy; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D033581:Stem Cell Transplantation; D015996:Survival Rate; D014182:Transplantation, Autologous; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D008558:Melphalan
keywords: Autologous transplantation; Base excision repair; Disease progression; Melphalan; Multiple myeloma; Nucleotide excision repair; Single nucleotide polymorphisms