title: Systems medicine: opportunities and challenges for systems biology approaches.
abstract: Technological advance have not only dramatically accelerated progress in medical knowledge and practice, but also revealed the enormous complexity of diseases and pathogenetic mechanisms. Can systems biology approaches and computational modelling help defeat the challenge of exploding complexity? Four review articles discuss the challenges and opportunities for such systems level approaches in medicine, pathology and drug development.
authors.affiliation: Systems Biology Ireland, Conway Institute of Biomolecular and Biomedical Research and School of Medicine and Medical Science, University College Dublin, Ireland.
authors.forename: Walter
authors.initials: W
authors.lastname: Kolch
authors.forename: Boris N
authors.initials: BN
authors.lastname: Kholodenko
mesh_terms: D003198:Computer Simulation; D015195:Drug Design; D006801:Humans; D008511:Medicine; D049490:Systems Biology