title: High energy diets prevent the enhancing effects of emotional arousal on memory.
abstract: Over the past five decades, per capita caloric intake has increased by approximately 28% in the United States. Excessive intake of calories from fats and sugars (high energy diets; HEDs) negatively impacts hippocampal-dependent memory. These deleterious effects of HEDs on hippocampal function involve HED-induced decreases in neuronal growth factors, neurogenesis, and synaptic plasticity. Given that HEDs also alter responses to emotional arousal, the present experiment determined whether the effects of HEDs on memory depend on the emotional arousal produced by the memory task during encoding. Rats were fed a high fat/sugar cafeteria-style diet for 4 weeks and then tested in a low or high emotional arousal version of a spatial object place recognition task. The results demonstrated that the HED prevented the memory-enhancing effects of emotional arousal. Thus, altered responses to emotional arousal likely contribute to HED-induced memory impairments, particularly in stressful memory tasks such as the spatial water maze.
authors.affiliation: Neuroscience Institute, Georgia State University.
authors.forename: Amy P
authors.initials: AP
authors.lastname: Ross
authors.forename: Jenna N
authors.initials: JN
authors.lastname: Darling
authors.forename: Marise B
authors.initials: MB
authors.lastname: Parent
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000633:toxicity; D004644:Emotions / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats