title: [Progress on Wnt/beta-catenin signal pathway regulating the cartilage metabolism in osteonecrosis].
abstract: More and more scholars agreed with the viewpoint that osteonecrosis relates with the metabolic activity of chondrocyte. Moreover,the activation of beta-catenin among Wnt/beta-catenin signal pathway can promote differentiation of chondrocyte and can promote differentiated cell death. So it suggests that this signal pathway should have an effect to occurrence and development of osteonecrosis by regulating the metabolic activity of chondrocyte. Through the establishment of conditional beta-catenin knockout mice,it is helpful to understand the pathogenesis of Wnt/beta-catenin signal pathway regulating cartilage metabolism. By the way we can understand the pathogenesis of osteonecrosis and give a targeted treatment to the disease. This article reviewed the relationship of three aspects of Wnt/beta-catenin signal pathway, cartilage metabolism and osteonecrosis.
authors.affiliation: Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.forename: Pei-jian
authors.initials: PJ
authors.lastname: Tong
authors.forename: Lu-wei
authors.initials: LW
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010020:Osteonecrosis / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000502:physiology*
chemical_list: D051176:beta Catenin