title: Role of premixed insulin analogues in the treatment of patients with type 2 diabetes mellitus: a narrative review.
abstract: Because of the progressive nature of type 2 diabetes mellitus (T2DM), insulin therapy will eventually become necessary in most patients. Recent evidence suggests that maintaining optimal glycemic control by early insulin therapy can reduce the risk of microvascular and macrovascular complications in patients with T2DM. The present review focuses on relevant clinical evidence supporting the use of premixed insulin analogues in T2DM when intensifying therapy, and as starter insulins in insulin-naïve patients. Our aim is to provide relevant facts and clinical evidence useful in the decision-making process of treatment selection and individualized treatment goal setting to obtain sustained blood glucose control.
authors.affiliation: Department of Endocrinology, Eli Lilly Vostok S.A., Moscow, Russian Federation.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Elizarova
authors.forename: Gagik R
authors.initials: GR
authors.lastname: Galstyan
authors.forename: Bruce H R
authors.initials: BH
authors.lastname: Wolffenbuttel
mesh_terms: D061265:Biphasic Insulins / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D061267:Insulin Aspart / Q000627:therapeutic use; D000069036:Insulin Glargine; D007336:Insulin, Isophane / Q000627:therapeutic use; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D061266:Insulin, Short-Acting; D016896:Treatment Outcome
chemical_list: D061265:Biphasic Insulins; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D061267:Insulin Aspart; D000069036:Insulin Glargine; D007336:Insulin, Isophane; D049528:Insulin, Long-Acting; D061266:Insulin, Short-Acting; C557564:insulin aspart, insulin aspart protamine drug combination 30:70
keywords: HbA1c; glycated hemoglobin; premixed insulin analogue; type 2 diabetes mellitus; 糖化血红蛋白，HbA1c，预混胰岛素类似物，2型糖尿病