title: Cutaneous T-cell lymphoma-like drug eruption in an HIV-positive patient taking vancomycin and rifampin.
abstract: BACKGROUND
  Cutaneous T-cell pseudolymphoma (CTPL) is a benign reactive T-cell lymphoproliferative subtype of pseudolymphoma. Some variants of CTPL can resemble the plaques of mycosis fungoides (MF). The vast majority of drug-induced cases have been associated with anticonvulsants. There is only one report in the literature documenting a case of vancomycin-induced CTPL.
  
  
  METHODS
  We report a cutaneous T-cell lymphoma-like eruption in a human immunodeficiency virus (HIV)-positive patient recently started on vancomycin and rifampin.
  
  
  RESULTS
  A skin biopsy showed several histologic features of MF with immunohistochemical and T-cell receptor gene rearrangement studies suggestive of CTPL. This atypical T-cell reaction mimicking MF completely resolved on cessation of rifampin followed by vancomycin.
  
  
  CONCLUSIONS
  Considering drug-induced causes of MF-like histologic changes is crucial to prevent unnecessary treatment for MF.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Macisaac
authors.forename: Chloé E
authors.initials: CE
authors.lastname: Ward
authors.forename: Melanie
authors.initials: M
authors.lastname: Pratt
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001706:Biopsy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004791:Enzyme Inhibitors / Q000009:adverse effects; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis; D012293:Rifampin / Q000009:adverse effects*; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D014640:Vancomycin / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D014640:Vancomycin; D012293:Rifampin