title: Alterations in HbA1c resulting from the donation of autologous blood for elective surgery in patients with diabetes mellitus.
abstract: BACKGROUND
  The aim of this study was to confirm the change in haemoglobin A1c consequent to pre-operative donation of autologous blood for elective surgery in patients with diabetes mellitus.
  
  
  METHODS
  For enrolment in this prospective study, patients had to be scheduled for multiple autologous blood donations at different times and have a haemoglobin A1c level more than 5.8% at the first donation. The values of four factors, haemoglobin, haemoglobin A1c, glycated albumin, and glycated albumin/haemoglobin A1c ratio were determined. Changes in the values of these four factors between before and after the blood donations were calculated.
  
  
  RESULTS
  In all 24 patients studied, haemoglobin and haemoglobin A1c decreased as a result of the autologous blood donations. The group with a reduced glycated albumin/haemoglobin A1c ratio had short intervals between blood donations. Correlations were observed between donation interval and change in haemoglobin A1c (r=-0.63, P=0.003), and between donation interval and change in the glycated albumin/haemoglobin A1c ratio (r=0.489, P=0.045).
  
  
  CONCLUSIONS
  Haemoglobin A1c levels are likely to be underestimated after autologous blood donation by patients with diabetes mellitus, so glycated albumin may be a better indicator of these patients' glycaemic control.
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugimoto
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Hayakawa
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Tokuno
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ogino
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Okuno
authors.affiliation: Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Hayashi
authors.affiliation: Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugiyama
authors.affiliation: Department of Blood Transfusion, Kobe University Hospital, Kobe, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Minami
mesh_terms: D000368:Aged; D001782:Blood Donors; D001793:Blood Preservation; D001804:Blood Transfusion, Autologous; D003920:Diabetes Mellitus / Q000097:blood*; D017558:Elective Surgical Procedures; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D006442:Glycated Hemoglobin; D007501:Iron