title: The network of P-glycoprotein and microRNAs interactions.
abstract: Overexpression of P-glycoprotein (P-gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P-gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P-gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P-gp may regulate the expression of miRs in the cell. Furthermore, both P-gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug-sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P-gp and miRs.
authors.affiliation: Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, Porto, Portugal; Center of Medicinal Chemistry of the University of Porto, CEQUIMED-UP, Porto, Portugal; Institute of Biomedical Sciences Abel Salazar, University of Porto, ICBAS-UP, Porto, Portugal.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Lopes-Rodrigues
authors.forename: Hugo
authors.initials: H
authors.lastname: Seca
authors.forename: Diana
authors.initials: D
authors.lastname: Sousa
authors.forename: Emília
authors.initials: E
authors.lastname: Sousa
authors.forename: Raquel T
authors.initials: RT
authors.lastname: Lima
authors.forename: M Helena
authors.initials: MH
authors.lastname: Vasconcelos
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000818:Animals; D018432:Drug Resistance, Multiple / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D035683:MicroRNAs
keywords: P-glycoprotein; cancer; drug resistance; exosomes; microRNAs; microvesicles