title: The role of periostin in tissue remodeling across health and disease.
abstract: Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial-mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
authors.affiliation: Program in Developmental Biology and Neonatal Medicine, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Conway
authors.forename: Kenji
authors.initials: K
authors.lastname: Izuhara
authors.forename: Yasusei
authors.initials: Y
authors.lastname: Kudo
authors.forename: Judith
authors.initials: J
authors.lastname: Litvin
authors.forename: Roger
authors.initials: R
authors.lastname: Markwald
authors.forename: Gaoliang
authors.initials: G
authors.lastname: Ouyang
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Arron
authors.forename: Cecile T J
authors.initials: CT
authors.lastname: Holweg
authors.forename: Akira
authors.initials: A
authors.lastname: Kudo
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D003238:Connective Tissue / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D012038:Regeneration / Q000235:genetics / Q000502:physiology; D059016:Tumor Microenvironment; D014945:Wound Healing
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human