title: Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis.
abstract: This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia. We searched relevant studies in electronic databases up to March 2013. Studies comparing malaria and STH co-infected patients with those not co-infected were included and the effect estimates were pooled using a random-effects model. We identified 30 studies for meta-analyses of which 17 were cross-sectional design. The majority of included studies (80%) were carried out in African countries. Among pregnant women, those infected with hookworm were found to have higher association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I(2): 0%). Among non-pregnant adults, the summary OR of the association between anemia and the combined malaria and STH was 2.91 (1.38-6.14). The summary OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect of malaria and STH on anemia. A subgroup analysis showed a higher risk of malaria infection in the primigravidae (summary OR: 1.61; 95% CI: 1.3-1.99; I(2): 0%). In conclusion, the malaria-STH co-infection was variable with complex outcomes on anemia.
authors.affiliation: School of Population Health, University of Queensland, Queensland 4006, Australia.
authors.forename: Cho
authors.initials: C
authors.lastname: Naing
authors.forename: Maxine A
authors.initials: MA
authors.lastname: Whittaker
authors.forename: Victor
authors.initials: V
authors.lastname: Nyunt-Wai
authors.forename: Simon A
authors.initials: SA
authors.lastname: Reid
authors.forename: Shew Fung
authors.initials: SF
authors.lastname: Wong
authors.forename: Joon Wah
authors.initials: JW
authors.lastname: Mak
authors.forename: Marcel
authors.initials: M
authors.lastname: Tanner
mesh_terms: D000293:Adolescent; D000328:Adult; D000349:Africa / Q000453:epidemiology; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D000818:Animals; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D003430:Cross-Sectional Studies; D005260:Female; D006373:Helminthiasis / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008288:Malaria / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000453:epidemiology; D015995:Prevalence; D012987:Soil / Q000469:parasitology; D055815:Young Adult
chemical_list: D012987:Soil
keywords: Anemia; Co-infection; Helminths; Malaria; Prevalence