title: Determination of the biodistribution and dosimetry of ¹²³I-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging.
abstract: In this study, (123)I-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately.
authors.affiliation: Medical Radiation Physics, Department of Clinical physiology and Nuclear medicine, Malmö, Lund University, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden. Electronic address: marie.sydoff@med.lu.se.
authors.forename: Marie
authors.initials: M
authors.lastname: Sydoff
authors.forename: Helena
authors.initials: H
authors.lastname: Lizana
authors.forename: Sören
authors.initials: S
authors.lastname: Mattsson
authors.forename: Michael G
authors.initials: MG
authors.lastname: Stabin
authors.forename: Sigrid
authors.initials: S
authors.lastname: Leide-Svegborn
mesh_terms: D000368:Aged; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging*; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014326:Tropanes / Q000493:pharmacokinetics
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: (123)I-FP-CIT; Biokinetics; Dosimetry; Lewy body dementia; Parkinson's disease