title: Comparison between Gleason score and apparent diffusion coefficient obtained from diffusion-weighted imaging of prostate cancer patients.
abstract: OBJECTIVE
  To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS).
  
  
  METHODS
  40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data.
  
  
  RESULTS
  Statistically significant differences of ADC (p < .05) were found among GS groups with a trend of decreasing ADC values with increasing GS.
  
  
  CONCLUSIONS
  The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.
authors.affiliation: I.R.C.C.S.-C.R.O.B. Rionero in Vulture (Pz), Italy,1.
authors.forename: Rocchina
authors.initials: R
authors.lastname: Caivano
authors.forename: Paola
authors.initials: P
authors.lastname: Rabasco
authors.forename: Antonella
authors.initials: A
authors.lastname: Lotumolo
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cirillo
authors.forename: Felice
authors.initials: F
authors.lastname: D'Antuono
authors.forename: Alexis
authors.initials: A
authors.lastname: Zandolino
authors.forename: Antonio
authors.initials: A
authors.lastname: Villonio
authors.forename: Luca
authors.initials: L
authors.lastname: Macarini
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Aldo
authors.initials: A
authors.lastname: Cammarota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies