title: Wound healing activity of Sida cordifolia Linn. in rats.
abstract: BACKGROUND
  The present study provides a scientific evaluation for the wound healing potential of ethanolic (EtOH) extract of Sida cordifolia Linn. (SCL) plant.
  
  
  METHODS
  Excision, incision and burn wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base). Group II was treated with 10% EtOH extract ointment. Group III was treated with standard silver sulfadiazine (0.01%) cream. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies.
  
  
  RESULTS
  It was noted that the effect produced by the ethanolic extract of SCL ointment showed significant (P < 0.01) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant (P < 0.01) changes when compared with the control.
  
  
  CONCLUSIONS
  The ethanolic extract ointment of SCL effectively stimulates wound contraction; increases tensile strength of excision, incision and burn wounds.
authors.affiliation: Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Neelbud, Bhopal, Madhya Pradesh, India.
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Pawar
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Chaurasiya
authors.forename: Harish
authors.initials: H
authors.lastname: Rajak
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Singour
authors.forename: Fedelic Ashish
authors.initials: FA
authors.lastname: Toppo
authors.forename: Ankit
authors.initials: A
authors.lastname: Jain
mesh_terms: D000818:Animals; D000431:Ethanol / Q000737:chemistry; D019660:Malvaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D000431:Ethanol
keywords: Burn injury; Sida cordifolia Linn. wound healing; excision injury; incision injury