title: Distribution of hydroxychloroquine in lymphoid tissue in a rabbit model for HIV infection.
abstract: Hydroxychloroquine has been proposed for HIV treatment; however, little is known about its disposition in the lymphatic system, where replication takes place. Therefore, its distribution in lymphoid tissues (Peyer's patches and popliteal, submandibular, femoral, splenic, and prescapular lymph nodes) was evaluated and compared with that in blood. Results showed a high affinity of hydroxychloroquine for all of these tissues, with higher affinity for the splenic and submandibular lymph nodes, suggesting its potential use as a coadjuvant in HIV therapy.
authors.affiliation: Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
authors.forename: Iliana
authors.initials: I
authors.lastname: González-Hernández
authors.forename: Lucinda
authors.initials: L
authors.lastname: Aguirre-Cruz
authors.forename: Julio
authors.initials: J
authors.lastname: Sotelo
authors.forename: Raquel
authors.initials: R
authors.lastname: López-Arellano
authors.forename: Adriana
authors.initials: A
authors.lastname: Morales-Hipólito
authors.forename: Helgi
authors.initials: H
authors.lastname: Jung-Cook
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy*; D006886:Hydroxychloroquine / Q000097:blood / Q000378:metabolism*; D008221:Lymphoid Tissue / Q000378:metabolism*; D008297:Male; D011817:Rabbits
chemical_list: D019380:Anti-HIV Agents; D006886:Hydroxychloroquine