title: New phenanthrene derivatives with nitric oxide inhibitory and radical-scavenging activities from Pholidota imbricata Hook.
abstract: One new phenanthrene derivative phoimbrtol A (1) with seven known compounds, loddigesiinol B (2), shanciol B (3), (-)-medioresinol (4), (-)-pinoresinol (5), quercetin 3-O-β-L-arabinofuranoside (6), luteolin 7-O-β-glucoside (7) and platycaryanin D (8) have been isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricata Hook. Their inhibitory effects on nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity were examined. Among these compounds, 8 exhibited the most potent activity at NO production inhibitory assay and DPPH radical scavenging assay, stronger than those of the familiar antioxidative agents, quercetin and resveratrol.
authors.affiliation: a Shenzhen Institute For Drug Control , Guangdong 518057 , P.R. China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Tiejie
authors.initials: T
authors.lastname: Wang
authors.forename: Pu
authors.initials: P
authors.lastname: Xie
authors.forename: Guo
authors.initials: G
authors.lastname: Yin
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D001713:Biphenyl Compounds / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010851:Picrates / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D016166:Free Radical Scavengers; D010616:Phenanthrenes; D010851:Picrates; D013267:Stilbenes; C551753:loddigesiinol B; C000591265:phoimbrtol A; D009569:Nitric Oxide; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl; D000077185:Resveratrol