title: A genomic variation map provides insights into the genetic basis of cucumber domestication and diversity.
abstract: Most fruits in our daily diet are the products of domestication and breeding. Here we report a map of genome variation for a major fruit that encompasses ~3.6 million variants, generated by deep resequencing of 115 cucumber lines sampled from 3,342 accessions worldwide. Comparative analysis suggests that fruit crops underwent narrower bottlenecks during domestication than grain crops. We identified 112 putative domestication sweeps; 1 of these regions contains a gene involved in the loss of bitterness in fruits, an essential domestication trait of cucumber. We also investigated the genomic basis of divergence among the cultivated populations and discovered a natural genetic variant in a β-carotene hydroxylase gene that could be used to breed cucumbers with enhanced nutritional value. The genomic history of cucumber evolution uncovered here provides the basis for future genomics-enabled breeding.
authors.affiliation: 1] Institute of Vegetables and Flowers of the Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture, Sino-Dutch Joint Laboratory of Horticultural Genomics, Beijing, China. [2].
authors.forename: Jianjian
authors.initials: J
authors.lastname: Qi
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Shen
authors.forename: Han
authors.initials: H
authors.lastname: Miao
authors.forename: Bingyan
authors.initials: B
authors.lastname: Xie
authors.forename: Xixiang
authors.initials: X
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Zeng
authors.forename: Shenhao
authors.initials: S
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Shang
authors.forename: Xingfang
authors.initials: X
authors.lastname: Gu
authors.forename: Yongchen
authors.initials: Y
authors.lastname: Du
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Jinhong
authors.initials: J
authors.lastname: Yuan
authors.forename: Xueyong
authors.initials: X
authors.lastname: Yang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Chen
authors.forename: Huiming
authors.initials: H
authors.lastname: Chen
authors.forename: Xingyao
authors.initials: X
authors.lastname: Xiong
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Zhangjun
authors.initials: Z
authors.lastname: Fei
authors.forename: Linyong
authors.initials: L
authors.lastname: Mao
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Thomas
authors.initials: T
authors.lastname: Städler
authors.forename: Susanne S
authors.initials: SS
authors.lastname: Renner
authors.forename: Sophien
authors.identifier: 0000000202900315
authors.initials: S
authors.lastname: Kamoun
authors.forename: William J
authors.initials: WJ
authors.lastname: Lucas
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Zhang
authors.forename: Sanwen
authors.identifier: 0000000285475309
authors.initials: S
authors.lastname: Huang
mesh_terms: D001947:Breeding / Q000379:methods; D002874:Chromosome Mapping / Q000379:methods; D018556:Crops, Agricultural / Q000235:genetics*; D018553:Cucumis sativus / Q000235:genetics*; D049810:Genetic Speciation; D014644:Genetic Variation; D018745:Genome, Plant; D005843:Geography; D012641:Selection, Genetic / Q000502:physiology