title: Is 1 mm thickness sec. Breslow the correct cut-off for sentinel node biopsy in melanoma? Report of six cases of metastasis by thin melanoma.
abstract: OBJECTIVE
  To reassess selection criteria for Sentinel Lymph Node Biopsy (SLNB) in patients with thin melanoma (Breslow ≤ 1 mm).
  
  
  METHODS
  Between January 2004 and November 2010 we observed 6 patients with lymph node metastasis from early melanoma (Breslow ranging from 0.3 mm to 0.9 mm, not ulcerated tumor, mitosis/ mmq < 1). Nobody had received a prior study of sentinel lymph node so all patients underwent enlarged lymphadenectomy of concerned lymphatic stations and cancer re-staging.
  
  
  RESULTS
  The pathological examination of lymph nodes has always confirmed metastatic melanoma. The average followup is currently 51,5 months: 3 of 6 patients presented recurrence that in one case led to death.
  
  
  CONCLUSIONS
  In the event of a thickness < 1 mm the probability of finding a positive sentinel lymph node is about 7%. Recent data have demonstrated a significant survival advantage to early therapeutic lymphadenectomy in melanoma.
  
  
  CONCLUSIONS
  Our experience, supported by the cases described and the literature, leads to propose the technique of SLNB to all patients with melanoma thicker than 0.5 mm, given the low morbidity and the important prognostic role of the procedure, in addition to the possibility of reducing the incidence of lymph node metastases.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Quarto
authors.forename: Luigi
authors.initials: L
authors.lastname: Sivero
authors.forename: Giacomo
authors.initials: G
authors.lastname: Benassai
authors.forename: Luigi
authors.initials: L
authors.lastname: Bucci
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Desiato
authors.forename: Stefano
authors.initials: S
authors.lastname: Perrotta
authors.forename: Gianluca
authors.initials: G
authors.lastname: Benassai
authors.forename: Salvatore
authors.initials: S
authors.lastname: Massa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000556:secondary*; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy / Q000592:standards*; D012878:Skin Neoplasms / Q000473:pathology*