title: Photosensitization of singlet oxygen and in vivo photodynamic therapeutic effects mediated by PEGylated W(18)O(49) nanowires.
abstract: Upon excitation with near-infrared light (980 nm), PEGylated W18 O49 nanowires can sensitize the formation of singlet oxygen and thus reactive oxygen species (ROS). The resulting photodynamic therapy (PDT) effect can cause the destruction of tumors in the absence of organic photosensitizers. PEG=poly(ethylene glycol), PTT=photothermal therapy.
authors.affiliation: Department of Chemistry, Frontier Research Centre on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan (Republic of China).
authors.forename: Poliraju
authors.initials: P
authors.lastname: Kalluru
authors.forename: Raviraj
authors.initials: R
authors.lastname: Vankayala
authors.forename: Chi-Shiun
authors.initials: CS
authors.lastname: Chiang
authors.forename: Kuo Chu
authors.initials: KC
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D053770:Nanowires / Q000737:chemistry* / Q000627:therapeutic use; D010087:Oxides / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry / Q000378:metabolism*; D019810:Sodium Azide / Q000737:chemistry / Q000494:pharmacology; D013696:Temperature; D014183:Transplantation, Heterologous; D014414:Tungsten / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D010087:Oxides; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D004317:Doxorubicin; C511604:tungsten oxide; D019810:Sodium Azide; D014414:Tungsten
keywords: nanowires; photodynamic therapy; photothermal therapy; reactive oxygen species; singlet oxygen