title: Heart rate regulation at different levels of convulsive readiness.
abstract: Heart rate variability parameters and the level of convulsive readiness during pentylenetetrazole-induced kindling in rats were analyzed using telemetric ECG and EEG monitoring. Analysis of ECG recorded over many days showed that heart rate variability was equally reduced after 7 and 27 days of kindling irrespective of the level of convulsive readiness. Reduced sympathovagal index after 7 days of kindling showed the compensatory character of changes. However, compensatory mechanisms cannot prevent high risk of life-threatening arrhythmias. High convulsive readiness after 27 days of kindling was accompanied by a shift of autonomic balance towards the increase in sympathetic tone, which may lead to decompensation and transition to a prenosological state.
authors.affiliation: Department of Anatomy and Physiology of Humans and Animals, Moscow State Pedagogical University, Russia. mamalyga_49@mail.ru.
authors.forename: M L
authors.initials: ML
authors.lastname: Mamalyga
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D006321:Heart / Q000503:physiopathology; D006339:Heart Rate; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010433:Pentylenetetrazole