title: Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD). Suppressor of cytokine signaling (SOCS) family members are involved in the pathogenesis of many inflammatory diseases and SOCS-3 has been shown to play an important role in the regulation, onset and maintenance of airway allergic inflammation indicating that SOCS-3 displays a potential therapeutic target for anti-inflammatory respiratory drugs development. Since chronic obstructive pulmonary disease (COPD) is also characterized by inflammatory changes and airflow limitation, the present study assessed the transcriptional expression of SOCS-3 in COPD.
  
  
  METHODS
  Real-time PCR was performed to assess quantitative changes in bronchial biopsies of COPD patients in comparison to unaffected controls.
  
  
  RESULTS
  SOCS-3 was significantly down-regulated in COPD at the transcriptional level while SOCS-4 and SOCS-5 displayed no change.
  
  
  CONCLUSIONS
  It can be concluded that the presently observed inhibition of SOCS-3 mRNA expression may be related to the dysbalance of cytokine signaling observed in COPD.
authors.forename: Jochen
authors.initials: J
authors.lastname: Springer
authors.forename: Frank R
authors.initials: FR
authors.lastname: Scholz
authors.forename: Christian
authors.initials: C
authors.lastname: Peiser
authors.forename: Q Thai
authors.initials: QT
authors.lastname: Dinh
authors.forename: Axel
authors.initials: A
authors.lastname: Fischer
authors.forename: David
authors.initials: D
authors.lastname: Quarcoo
authors.affiliation: Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University, Frankfurt 60590, Germany. umweltmedizin@uni-frankfurt.de.
authors.forename: David A
authors.initials: DA
authors.lastname: Groneberg