title: Acetaminophen in children: an old drug with new warnings.
abstract: OBJECTIVE
  I frequently suggest to parents to use acetaminophen to treat their children's fever and pain. Recently, I had a child in my office who presented with a target-lesion skin rash a day after receiving acetaminophen. The rash resolved after 3 days and after stopping administration of acetaminophen. Does acetaminophen carry a risk of adverse events such as this?
  
  
  CONCLUSIONS
  Like any other medication or active substance, acetaminophen preparations might carry a risk of adverse events. In recent years a potential association between acetaminophen and asthma was investigated, and the US Food and Drug Administration recently published a warning about potential severe but rare skin reactions associated with acetaminophen. Although acetaminophen is mostly a safe medication, health care providers should be alert and advise parents about the possibility of rare but severe adverse events.
authors.affiliation: BC Children's Hospital, Department of Pediatrics, Room K4-226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4. rgoldman@cw.bc.ca.
authors.forename: Ran D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D002648:Child; D017277:Drug Approval; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D014481:United States
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen