title: Cardiac sympathetic activity assessed by heart rate variability indicates myocardial ischemia on cold exposure in diabetes.
abstract: Measurement of heart rate variability (HRV) is a non-invasive technique that can be used to investigate functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activities. It is reported that dilatation of coronary microcirculation by augmentation of sympathetic nerve activity (SNA) caused by cold exposure was impaired in diabetes. The question of whether or not SNA in HRV could respond to coronary ischemia was evaluated by cold exposure in diabetic rats. It was found that diabetes with weight loss significantly increased SNA both in baseline and cold exposure, compared with control. A correspondence was also found with coronary ischemia. It can be concluded that measurement of HRV may provide useful information regarding the coronary risk of cold exposure in diabetes. (English translation of J Jpn Coll Angiol 2012; 52: 295-301).
authors.affiliation: School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Sasaki
authors.forename: Shonosuke
authors.initials: S
authors.lastname: Matsushita
authors.forename: Fujio
authors.initials: F
authors.lastname: Sato
authors.forename: Chiho
authors.initials: C
authors.lastname: Tokunaga
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hyodo
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Sakakibara
keywords: cold exposure; diabetes; heart rate variability (HRV); rat; sympathetic nerve activity (SNA)