title: Study of the absolute bioavailability of citrocard, a new GABA derivative.
abstract: The main pharmacokinetic parameters attest to short elimination half-life and mean retention time of a single citrocard molecule. The average rate of plasma concentration decrease of the compound determined small area under the pharmacokinetic curve. Steady-state distribution volume was low and only slightly surpassed the volume of extracellular body fluids in rat, which indicated moderate capacity of citrocard to distribution and accumulation in the tissues, which is seen from low systemic clearance (Cl) despite the quick elimination of the compound. Absolute bioavailability was 64%.
authors.affiliation: Laboratory of Pharmacological Kinetics, Department of Pharmacology and Biopharmaceutics, Faculty of Advanced Medical Studies, Volgograd State Medical University, Russia. vnperfilova@mail.ru.
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: A F
authors.initials: AF
authors.lastname: Ryabukha
authors.forename: E A
authors.initials: EA
authors.lastname: Suchkov
authors.forename: S A
authors.initials: SA
authors.lastname: Lebedeva
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D018682:GABA Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid