title: Oxygen metabolism in oral cancer: HIF and GLUTs (Review).
abstract: Oral cancer is a significant cause of morbidity and mortality, and has a poor prognosis. This has encouraged additional studies into factors that may affect the development of this disease. The biological behavior of malignant neoplasms is complex. Studies have investigated the energy metabolism of tumor cells, in an endeavor to elucidate the tumor biology. The identification of molecular signatures and mechanisms, in order to understand tumor progression, may facilitate the identification of novel predictive and prognostic markers. Pathways that influence tumor progression, such as those involving hypoxia-inducible factor (HIF) and glucose transporter (GLUT) proteins, have been the targets of recent studies.
authors.affiliation: Division of Oral Pathology, School of Dentistry, Federal University of Ceará, Sobral Campus, Sobral 62010-560;
authors.forename: Karuza Maria Alves
authors.initials: KM
authors.lastname: Pereira
authors.forename: Filipe Nobre
authors.initials: FN
authors.lastname: Chaves
authors.forename: Thales Salles Angelim
authors.initials: TS
authors.lastname: Viana
authors.forename: Francisco Samuel Rodrigues
authors.initials: FS
authors.lastname: Carvalho
authors.forename: Fábio Wildson Gurgel
authors.initials: FW
authors.lastname: Costa
authors.forename: Ana Paula Negreiros Nunes
authors.initials: AP
authors.lastname: Alves
authors.forename: Fabrício Bitu
authors.initials: FB
authors.lastname: Sousa
keywords: cancer; carcinoma; facilitative hypoxia-inducible factor-1α; glucose transport proteins; oral cancer; squamous cells