title: Optical spectroscopic methods for intraoperative diagnosis.
abstract: Molecular analytical methods are increasingly needed for a quick and reliable analysis of tissue in an operating room to provide more information during operations. In this Trends article, we highlight the current state and the developments of optical spectroscopic methods as intra operative tools. The clinical problem and challenges are illustrated on the example of brain tumor surgery. While fluorescence microscopy is already used, vibrational spectroscopy techniques will complement the standard method for brain tissue diagnostics. New portable instruments are currently available and can be stationed in the operating room for quick evaluation of tissue. The promise and limitations of fluorescence and vibrational spectroscopy as intraoperative tools are surveyed in this report.
authors.affiliation: Faculty of Medicine Carl Gustav Carus, Clinical Sensoring and Monitoring, Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany, gerald.steiner@tu-dresden.de.
authors.forename: Gerald
authors.initials: G
authors.lastname: Steiner
authors.forename: Matthias
authors.initials: M
authors.lastname: Kirsch
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005909:Glioblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007430:Intraoperative Care / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D019095:Point-of-Care Systems; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation* / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods