title: OTUD5 regulates p53 stability by deubiquitinating p53.
abstract: BACKGROUND
  The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its negative regulators ubiquitin ligase MDM2.
  
  
  RESULTS
  In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. OTUD5 forms a direct complex with p53 and controls level of ubiquitination. The function of OTUD5 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
  
  
  CONCLUSIONS
  As a novel deubiquitinating enzyme for p53, OTUD5 is required for the stabilization and the activation of a p53 response.
authors.affiliation: Department of Radiotherapy, Changzhou Tumor Hospital, Soochow University, Changzhou, China ; School of Radiation Medicine and Protection and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China.
authors.forename: Judong
authors.initials: J
authors.lastname: Luo
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Lu
authors.forename: Xujing
authors.initials: X
authors.lastname: Lu
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Jianping
authors.initials: J
authors.lastname: Cao
authors.forename: Shuyu
authors.initials: S
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Ling
authors.forename: Xifa
authors.initials: X
authors.lastname: Zhou
mesh_terms: D017209:Apoptosis; D002460:Cell Line; D004249:DNA Damage; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D055550:Protein Stability; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry* / Q000378:metabolism*; D064570:Ubiquitin-Specific Proteases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D016159:Tumor Suppressor Protein p53; D010450:Endopeptidases; C525076:OTUD5 protein, human; D064570:Ubiquitin-Specific Proteases