title: Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte.
abstract: Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA.
authors.forename: Paige Selvy
authors.initials: PS
authors.lastname: Dunphy
authors.forename: Tian
authors.initials: T
authors.lastname: Luo
authors.forename: Jere W
authors.initials: JW
authors.lastname: McBride
mesh_terms: D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D002467:Cell Nucleus / Q000378:metabolism; D004536:Ehrlichia / Q000502:physiology*; D016873:Ehrlichiosis / Q000378:metabolism* / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D042541:Intracellular Space / Q000276:immunology / Q000382:microbiology; D010586:Phagocytes / Q000378:metabolism* / Q000382:microbiology*; D011485:Protein Binding; D021381:Protein Transport; D050051:Transient Receptor Potential Channels / Q000378:metabolism
chemical_list: D017487:Ankyrins; D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D050051:Transient Receptor Potential Channels
keywords: Effector; Ehrlichia; Human monocytotropic ehrlichiosis; Moonlighting protein; Nucleomodulin; Post translational modification; Tandem repeat protein; Type 1 secretion system; Zoonosis