title: Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis.
abstract: OBJECTIVE
  We compared the prevalence and the clustering of the metabolic syndrome (MetS) components (obese body mass index [BMI; ≥30 kg/m(2) ], hypertriglyceridemia, low high-density lipids, hypertension, and diabetes mellitus) in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in the Consortium of Rheumatology Researchers of North America (CORRONA) Registry.
  
  
  METHODS
  We included CORRONA participants with a rheumatologist-confirmed clinical diagnosis of PsA or RA with complete data. We used a modified definition of MetS that did not include insulin resistance, waist circumference, or blood pressure measurements. Logistic regression models were adjusted for age, sex, and race.
  
  
  RESULTS
  In the overall CORRONA population, the rates of diabetes mellitus and obesity were significantly higher in PsA compared with RA. In 294 PsA and 1,162 RA participants who had lipids measured, the overall prevalence of MetS in PsA versus RA was 27% versus 19%. The odds ratio (OR) of MetS in PsA versus RA was 1.44 (95% confidence interval [95% CI] 1.05-1.96, P = 0.02). The prevalence of hypertriglyceridemia was higher in PsA compared with RA (38% versus 28%; OR 1.51 [95% CI 1.15-1.98], P = 0.003). The prevalence of type 2 diabetes mellitus was also higher in PsA compared with RA (15% versus 11%; OR 1.56 [95% CI 1.07-2.28], P = 0.02) in the adjusted model. Similarly, higher rates of hypertriglyceridemia and diabetes mellitus were observed in the subgroup of PsA and RA patients with obese BMI.
  
  
  CONCLUSIONS
  Compared with RA, PsA is associated with higher rates of obesity, diabetes mellitus, and hypertriglyceridemia.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Monalyn
authors.initials: M
authors.lastname: Labitigan
authors.forename: Asena
authors.initials: A
authors.lastname: Bahče-Altuntas
authors.forename: Joel M
authors.initials: JM
authors.lastname: Kremer
authors.forename: George
authors.initials: G
authors.lastname: Reed
authors.forename: Jeff D
authors.initials: JD
authors.lastname: Greenberg
authors.forename: Nicole
authors.initials: N
authors.lastname: Jordan
authors.forename: Chaim
authors.initials: C
authors.lastname: Putterman
authors.forename: Anna
authors.initials: A
authors.lastname: Broder
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012042:Registries; D014481:United States / Q000453:epidemiology
chemical_list: D008055:Lipids