title: Transplantation: Autoantibodies-epiphenomena or biological clues.
abstract: The potential roles for autoantibodies in renal transplantation are increasing, as illustrated by a recent report of polyreactive autoantibodies produced by B-cell clones from a kidney transplant recipient that can bind apoptotic cells and activate complement. Such autoantibodies have the potential to amplify microcirculation injury caused by alloantibody in antibody-mediated transplant rejection.
authors.affiliation: Alberta Transplant Applied Genomics Centre, University of Alberta, 250 Heritage Medical Research Centre, Edmonton, AB T6G 2S2, Canada.
authors.forename: Philip F
authors.initials: PF
authors.lastname: Halloran
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001323:Autoantibodies / Q000097:blood*; D003167:Complement Activation / Q000276:immunology*; D015935:Complement C4b / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D010446:Peptide Fragments / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010446:Peptide Fragments; D015935:Complement C4b