title: Rapid progression of Graves' ophthalmopathy despite the administration of thiamazole.
abstract: A 42-year-old female with body weight loss, finger tremors and ocular discomfort was diagnosed with Graves' disease complicated with ophthalmopathy. Thiamazole therapy rapidly improved her hyperthyroidism. However, she was admitted to our hospital because her eye symptoms acutely deteriorated over a period of two weeks. She had ocular immotility, exposure keratitis, conjunctival edema, severe proptosis and visual impairment with a high titer of serum thyroid-stimulating antibody (TSAb). Methylprednisolone pulse therapy at a dose of 500 mg/day improved her eye symptoms. Although the mechanism of the progression of Graves' ophthalmopathy has not yet been elucidated, special attention should be paid to the occurrence of ophthalmopathy even after the initiation of thiamazole therapy.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Katsuyama
authors.forename: Masaya
authors.initials: M
authors.lastname: Takeda
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Kishio
authors.initials: K
authors.lastname: Toma
authors.forename: Kenichi
authors.initials: K
authors.lastname: Inagaki
authors.forename: Ken-Ei
authors.initials: KE
authors.lastname: Sada
authors.forename: Yukari
authors.initials: Y
authors.lastname: Mimura
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage*; D018450:Disease Progression; D005260:Female; D049970:Graves Ophthalmopathy / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008713:Methimazole / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole