title: Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment.
abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. In the last years, abnormalities of lipid metabolism and in particular of docosahexaenoic acid (DHA) have been recently linked with the development of the disease. According to the recent studies showing how hydroxylation of fatty acids enhances their biological activity, here we show that chronic treatment with a hydroxylated derivative of DHA, the 2-hydroxy-DHA (2OHDHA) in the 5XFAD transgenic mice model of AD improves performance in the radial arm maze test and restores cell proliferation in the dentate gyrus, with no changes in the presence of beta amyloid (Aβ) plaques. These results suggest that 2OHDHA induced restoration of cell proliferation can be regarded as a major component in memory recovery that is independent of Aβ load thus, setting the starting point for the development of a new drug for the treatment of AD.
authors.affiliation: Molecular Cell Biomedicine, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut, University of the Balearic Islands, Bldg. Guillem Colom, Crta. Valldemossa, Km 7,5, 07122, Palma, Balearic Islands, Spain.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Fiol-deRoque
authors.forename: Raquel
authors.initials: R
authors.lastname: Gutierrez-Lanza
authors.forename: Silvia
authors.initials: S
authors.lastname: Terés
authors.forename: Manuel
authors.initials: M
authors.lastname: Torres
authors.forename: Pere
authors.initials: P
authors.lastname: Barceló
authors.forename: Rubén V
authors.initials: RV
authors.lastname: Rial
authors.forename: Alexei
authors.initials: A
authors.lastname: Verkhratsky
authors.forename: Pablo V
authors.initials: PV
authors.lastname: Escribá
authors.forename: Xavier
authors.initials: X
authors.lastname: Busquets
authors.forename: José J
authors.initials: JJ
authors.lastname: Rodríguez
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D018891:Dentate Gyrus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D018697:Nootropic Agents / Q000494:pharmacology*
chemical_list: C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; D018697:Nootropic Agents; D004281:Docosahexaenoic Acids