title: Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.
abstract: Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption upon initial exposure to a novel flavor, but Narp KO mice did not increase consumption with subsequent exposures to the novel flavor like the WT mice. Therefore, Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.
authors.affiliation: Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: ablouin@scripps.edu.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Blouin
authors.forename: Jongah J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Bo
authors.initials: B
authors.lastname: Tao
authors.forename: Dani R
authors.initials: DR
authors.lastname: Smith
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Johnson
authors.forename: Jay M
authors.initials: JM
authors.lastname: Baraban
authors.forename: Irving M
authors.initials: IM
authors.lastname: Reti
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D002097:C-Reactive Protein / Q000172:deficiency*; D005106:Exploratory Behavior / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000172:deficiency*; D010698:Phobic Disorders / Q000235:genetics / Q000503:physiopathology*; D020127:Recovery of Function / Q000235:genetics*; D013997:Time Factors; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D009419:Nerve Tissue Proteins; D000099153:Pentraxins
keywords: Addiction; Extinction; Narp; Neophobia; Novelty; Recovery from neophobia