title: Carbapenemase-producing Enterobacteriaceae during 2011-12 in the Bolzano area (Northern Italy): increasing diversity in a low-endemicity setting.
abstract: The recent (2011-2012) distribution of carbapenemase determinants in Enterobacteriaceae was studied in the Bolzano area (Northern Italy). Low proportions of carbapenemase producers were found for Escherichia coli (0.2%), Citrobacter freundii (1.1%), Klebsiella pneumoniae (1.3%), Klebsiella oxytoca (1.6%) and Enterobacter spp (1.8%). Although VIM-1 remained the most common carbapenemase, the emergence of K. pneumoniae producing KPC-3 and of E. coli producing OXA-48 was observed. Of concern is the spread of the hyperepidemic strains E. coli ST131 producing VIM-1 and K. pneumoniae ST258 producing KPC-3. Low essential and category agreements between the reference broth microdilution and commercial methods were observed for carbapenems.
authors.affiliation: Laboratory of Microbiology and Virology, Bolzano Health District, Bolzano, Italy.
authors.forename: Richard
authors.initials: R
authors.lastname: Aschbacher
authors.forename: Tommaso
authors.initials: T
authors.lastname: Giani
authors.forename: Daniele
authors.initials: D
authors.lastname: Corda
authors.forename: Viola
authors.initials: V
authors.lastname: Conte
authors.forename: Fabio
authors.initials: F
authors.lastname: Arena
authors.forename: Valentina
authors.initials: V
authors.lastname: Pasquetto
authors.forename: Katia
authors.initials: K
authors.lastname: Scalzo
authors.forename: Maira
authors.initials: M
authors.lastname: Nicoletti
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pagani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D004755:Enterobacteriaceae / Q000145:classification / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology*; D014644:Genetic Variation; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D055815:Young Adult; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Carbapenemases; Enterobacteriaceae; KPC; OXA-48; VIM