title: Proton magnetic spectroscopy agreed better with magnetic resonance image to lateralization of epileptogenic zone than with surface electroencephalography.
abstract: OBJECTIVE
  To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI) and surface electroencephalography (EEG) in extratemporal neocortical epilepsies.
  
  
  METHODS
  A cross-sectional study, type series of cases included 33 patients, age range 13-59 years old, of both gender, presenting structural alteration identified by MRI (75.8%) or by neurophysiologic techniques (72.7%). The variables were alterations of N-acetyl-aspartate/choline, N-acetyl-aspartate/creatine, choline/creatine, and N-acetyl-aspartate/cho-line+creatine coefficient of asymmetry.
  
  
  RESULTS
  Agreement rates of lateralization by coefficient of asymmetry of NAA/Cho, NAA/Cr, Co/Cr, and NAA/Cho+Cr with MRI, independent of alteration of surface EEG, were equal to 93.3, 57.9, 15.4, and 93.3%, respectively, modifying to 100, 33.3, 0, and 100%, in 16 patients, with lateralization agreement of MRI and surface EEG.
  
  
  CONCLUSIONS
  Proton magnetic spectroscopy agreed better with MRI to lateralization of epileptogenic zone than with surface EEG.
authors.affiliation: Epilepsy and Neurophysiology Center, Neurology Department, Hospital da Restauração, RecifePE, Brazil.
authors.forename: Ricardo André Amorim
authors.initials: RA
authors.lastname: Leite
authors.forename: Maria Concépcion Garcia
authors.initials: MC
authors.lastname: Otaduy
authors.forename: Gilson Edmar Gonçalves E
authors.initials: GE
authors.lastname: Silva
authors.forename: Maria Lúcia Brito
authors.initials: ML
authors.lastname: Ferreira
authors.forename: Maria de Fátima Vasco
authors.initials: Mde F
authors.lastname: Aragão
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001923:Brain Chemistry; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D003430:Cross-Sectional Studies; D004569:Electroencephalography / Q000379:methods*; D004828:Epilepsies, Partial / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline