title: Time perception impairs sensory-motor integration in Parkinson's disease.
abstract: It is well known that perception and estimation of time are fundamental for the relationship between humans and their environment. However, this temporal information processing is inefficient in patients with Parkinson' disease (PD), resulting in temporal judgment deficits. In general, the pathophysiology of PD has been described as a dysfunction in the basal ganglia, which is a multisensory integration station. Thus, a deficit in the sensorimotor integration process could explain many of the Parkinson symptoms, such as changes in time perception. This physiological distortion may be better understood if we analyze the neurobiological model of interval timing, expressed within the conceptual framework of a traditional information-processing model called "Scalar Expectancy Theory". Therefore, in this review we discuss the pathophysiology and sensorimotor integration process in PD, the theories and neural basic mechanisms involved in temporal processing, and the main clinical findings about the impact of time perception in PD.
authors.forename: Marina
authors.initials: M
authors.lastname: Lucas
authors.forename: Fernanda
authors.initials: F
authors.lastname: Chaves
authors.forename: Silmar
authors.initials: S
authors.lastname: Teixeira
authors.forename: Diana
authors.initials: D
authors.lastname: Carvalho
authors.forename: Caroline
authors.initials: C
authors.lastname: Peressutti
authors.forename: Juliana
authors.initials: J
authors.lastname: Bittencourt
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez-González
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Antonio Egidio
authors.initials: AE
authors.lastname: Nardi
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
authors.affiliation: Sleep and Movement Disorders Clinic and Transcranial Magnetic Stimulation Unit, Hospital General Dr, Manuel Gea González, México D,F,, Mexico. arias@email.ifc.unam.mx.
authors.forename: Oscar
authors.initials: O
authors.lastname: Arias-Carrión