title: Who's really in control: microbial regulation of protein trafficking in the epithelium.
abstract: Due to evolutionary pressure, there are many complex interactions at the interface between pathogens and eukaryotic host cells wherein host cells attempt to clear invading microorganisms and pathogens counter these mechanisms to colonize and invade host tissues. One striking observation from studies focused on this interface is that pathogens have multiple mechanisms to modulate and disrupt normal cellular physiology to establish replication niches and avoid clearance. The precision by which pathogens exert their effects on host cells makes them excellent tools to answer questions about cell physiology of eukaryotic cells. Furthermore, an understanding of these mechanisms at the host-pathogen interface will benefit our understanding of how pathogens cause disease. In this review, we describe a few examples of how pathogens disrupt normal cellular physiology and protein trafficking at epithelial cell barriers to underscore how pathogens modulate cellular processes to cause disease and how this knowledge has been utilized to learn about cellular physiology.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hendricks
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Bomberger
mesh_terms: D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D058947:Bacterial Secretion Systems; D004705:Endocytosis / Q000276:immunology; D004848:Epithelium / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion; D021381:Protein Transport
chemical_list: D058947:Bacterial Secretion Systems
keywords: endocytosis; epithelium; exocytosis; microbe; pathogen