title: Aspirin resistance in patients with impaired renal functions.
abstract: BACKGROUND
  Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney diseases (CKD). Aspirin resistance (AR) worsens prognosis in CVD.
  
  
  OBJECTIVE
  The aim of this study was to detect AR prevalence in this patient group.
  
  
  METHODS
  The 203 patients (mean age 61.84 ± 11.51 years, 128 [63.1%] male) with stable coronary artery disease included in the study were grouped into four study groups according to their estimated glomerular filtration rate (eGFR) values. Multiplate test was used to determine AR. Platelet aggregation results were presented as aggregation unit (AU) × min and values over 300 AU × min were accepted as AR.
  
  
  RESULTS
  61 (30.04%) patients in the whole study population were found to have AR. Differences were detected between AR ratios and multiplate values of the patient groups (p = 0.006 and p = 0.002). AR ratio was highest in patient group 4 (eGFR < 30 mL/min/1.73 m²) and/or on chronic haemodialysis therapy, whereas there was little difference among the other three groups. In multivariate analysis, while AR status was independently related to female sex (OR = 2.31,CI 1.14-4.65, p = 0.019) and mean platelet volume (MPV) (OR = 1.68, CI 1.21-2.33, p = 0.002), multiplate test results were independently related to MPV (b = 0.265, p < 0.0001) and eGFR (b = -0.165, p = 0.025).
  
  
  CONCLUSIONS
  The AR ratio was found to be high in severe CKD patients, especially haemodialysis patients, but not in mild and moderate CKD patients. This increased AR ratio in severe CKD patients may affect the prognosis in patients who already have an increased risk for cardiovascular complications.
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey. drhaleunalaksu@gmail.com.
authors.forename: Hale Unal
authors.initials: HU
authors.lastname: Aksu
authors.forename: Ender
authors.initials: E
authors.lastname: Oner
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erturk
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aksu
authors.forename: Nilgun
authors.initials: N
authors.lastname: Isıksacan
authors.forename: Begum
authors.initials: B
authors.lastname: Ozalp
authors.forename: Gulsah
authors.initials: G
authors.lastname: Akture
authors.forename: Ertan
authors.initials: E
authors.lastname: Akbay
authors.forename: Leyla
authors.initials: L
authors.lastname: Ozer
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Erol
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000188:drug therapy*; D012307:Risk Factors
chemical_list: D001241:Aspirin