title: Enhancement of mitochondrial function correlates with the extension of lifespan by caloric restriction and caloric restriction mimetics in yeast.
abstract: Caloric restriction mimetics (CRMs) have been developed to mimic the effects of caloric restriction (CR). However, research reports for the effects of CRMs are often times inconsistent across different research groups. Therefore, in this study, we compared seven identified CRMs which extend the lifespans of various organisms including caffeine, curcumin, dapsone, metformin, rapamycin, resveratrol, and spermidine to CR for mitochondrial function in a single model, Saccharomyces cerevisiae. In this organism, rapamycin extended chronological lifespan (CLS), but other CRMs failed to extend CLS. Rapamycin enhanced mitochondrial function like CR did, but other CRMs did not. Both CR and rapamycin worked on mitochondrial function, but they worked at different windows of time during the chronological aging process.
authors.affiliation: Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
authors.forename: Kyung-Mi
authors.initials: KM
authors.lastname: Choi
authors.forename: Hye-Lan
authors.initials: HL
authors.lastname: Lee
authors.forename: Young-Yon
authors.initials: YY
authors.lastname: Kwon
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kang
authors.forename: Sung-Keun
authors.initials: SK
authors.lastname: Lee
authors.forename: Cheol-Koo
authors.initials: CK
authors.lastname: Lee
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000187:drug effects; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D020123:Sirolimus / Q000494:pharmacology; D013997:Time Factors
chemical_list: D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D020123:Sirolimus
keywords: ATP; CLS; CR; CRMs; Caloric restriction; Caloric restriction mimetics; MMP; Mitochondrial membrane potential; RLS; ROS; Rapamycin; Reactive oxygen species; caloric restriction; caloric restriction mimetics; chronological lifespan; mitochondrial membrane potential; reactive oxygen species; replicative lifespan