title: Mechanisms of stimulating effect of glycyram and D-glucuronic acid on granulocytopoiesis suppression by 5-fluorouracil.
abstract: We compared hemostimulating activity of glycyram and a preparation of D-glucuronic acid on the model of granulocytic hemopoiesis suppressed by 5-fluorouracil. Different mechanisms were shown to underlie activation of hemopoiesis by the above preparations: D-glucuronic acid directly affects hemopoietic cells, while glycyram modulates local mechanisms regulating hemopoiesis.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: D V
authors.initials: DV
authors.lastname: Reykhart
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D005472:Fluorouracil / Q000494:pharmacology; D020723:Glucuronic Acid / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D020723:Glucuronic Acid; D006034:Glycyrrhetinic Acid; D005472:Fluorouracil