title: Cytology in nipple aspirate fluid during a randomized soy food intervention among premenopausal women.
abstract: Because soy food consumption may influence breast tissue activity, we examined its effect on the presence of epithelial cells in nipple aspirate fluid (NAF). In a randomized, crossover design, 82 premenopausal women completed a high-soy and a low-soy diet for 6 mo each, separated by a 1-mo washout period. They provided NAF samples at baseline, 6 mo, and 13 mo during the midluteal phase of the menstrual cycle. Papanicolaou-stained cytology slides (for 33 women at baseline, 24 at low-soy, and 36 at high-soy) were evaluated in women with sufficient NAF. Mixed models evaluated the effect of the high-soy diet on epithelial cytology as compared to baseline and the low-soy diet. At the end of the high-soy diet, cytological subclass had decreased in 8 (24%) and increased in 3 (9%) women as compared to baseline, whereas the respective values were 3 (14%) and 6 (29%) for the low-soy diet samples (P = 0.32). Only the change in subclass indicated a trend in lower cytological class (P = 0.06). Contrary to an earlier report, the number of NAF samples with hyperplastic epithelial cells did not increase after a soy intervention in amounts consumed by Asians.
authors.affiliation: a University of Hawaii Cancer Center , Honolulu , Hawaii , USA.
authors.forename: Gertraud
authors.initials: G
authors.lastname: Maskarinec
authors.forename: Shana
authors.initials: S
authors.lastname: Suzuki
authors.forename: Ian S
authors.initials: IS
authors.lastname: Pagano
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Adrian A
authors.initials: AA
authors.lastname: Franke
authors.forename: Hormoz
authors.initials: H
authors.lastname: Ehya
mesh_terms: D000328:Adult; D001940:Breast / Q000378:metabolism; D018592:Cross-Over Studies; D004032:Diet; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D055966:Nipple Aspirate Fluid / Q000166:cytology* / Q000378:metabolism; D017697:Premenopause; D045730:Soy Foods