title: End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.
abstract: A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge (USA).
authors.forename: Salvatore
authors.initials: S
authors.lastname: Mascia
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Heider
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.forename: Richard
authors.initials: R
authors.lastname: Lakerveld
authors.forename: Brahim
authors.initials: B
authors.lastname: Benyahia
authors.forename: Paul I
authors.initials: PI
authors.lastname: Barton
authors.forename: Richard D
authors.initials: RD
authors.lastname: Braatz
authors.forename: Charles L
authors.initials: CL
authors.lastname: Cooney
authors.forename: James M B
authors.initials: JM
authors.lastname: Evans
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Jamison
authors.forename: Klavs F
authors.initials: KF
authors.lastname: Jensen
authors.forename: Allan S
authors.initials: AS
authors.lastname: Myerson
authors.forename: Bernhardt L
authors.initials: BL
authors.lastname: Trout
mesh_terms: D000143:Acids / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D002384:Catalysis; D003460:Crystallization; D004339:Drug Compounding; D005650:Fumarates / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013678:Technology, Pharmaceutical
chemical_list: D000143:Acids; D000577:Amides; D005650:Fumarates; D004364:Pharmaceutical Preparations; C446481:aliskiren
keywords: continuous processing; flow chemistry; lactones; protecting groups; synthetic methods