title: Anti-tau antibodies: hitting the target.
abstract: Immunotherapies targeting tau in mouse models of human tauopathies could have disease-modifying effects. In this issue of Neuron, Yanamandra et al. (2013) use tau antibodies, which effectively block tau seeding in culture, to attenuate tauopathy and improve cognition in mutant tau mouse models.
authors.affiliation: Departments of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, FL 32610, USA. Electronic address: tgolde@ufl.edu.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde
authors.forename: Jada
authors.initials: J
authors.lastname: Lewis
authors.forename: Nikolaus R
authors.initials: NR
authors.lastname: McFarland
mesh_terms: D000818:Animals; D006801:Humans; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy; D016875:tau Proteins / Q000037:antagonists & inhibitors / Q000276:immunology; D024801:Tauopathies / Q000188:drug therapy
chemical_list: D000911:Antibodies, Monoclonal; D016875:tau Proteins