title: Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes.
abstract: OBJECTIVE
  To determine the relationship between macular ganglion cell-inner plexiform layer (GC-IPL) thickness and optic disc/retinal nerve fibre layer (RNFL) parameters in non-glaucomatous eyes measured by spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  491 non-glaucomatous Chinese aged 40-80 years were recruited from a population-based study and underwent standardised ophthalmic examination. SD-OCT was used to measure GC-IPL thickness, optic disc parameters and RNFL thickness. Univariate and multiple linear regression analyses were performed to assess the association between GC-IPL and optic disc/RNFL parameters.
  
  
  RESULTS
  In univariate analyses, all RNFL parameters and rim area were significantly correlated with all macular GC-IPL parameters (p<0.001, r=0.12-0.56). In multiple regression analyses, after adjusting for age, gender, disc area, signal strength and axial length, average RNFL thickness (per µm decrease) was most strongly correlated with average GC-IPL thickness (β=-0.30, standardised β=-0.499, p<0.001) compared with other optic disc/RNFL parameters.
  
  
  CONCLUSIONS
  Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.
authors.affiliation: Singapore Eye Research Institute, Singapore National Eye Centre, , Singapore, Singapore.
authors.forename: Yih-Chung
authors.initials: YC
authors.lastname: Tham
authors.forename: Carol Y
authors.initials: CY
authors.lastname: Cheung
authors.forename: Victor T
authors.initials: VT
authors.lastname: Koh
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sidhartha
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Strouthidis
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008266:Macula Lutea / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000592:standards; D014794:Visual Fields