title: The renin-angiotensin system in adipose tissue and its metabolic consequences during obesity.
abstract: Obesity is a worldwide disease that is accompanied by several metabolic abnormalities such as hypertension, hyperglycemia and dyslipidemia. The accelerated adipose tissue growth and fat cell hypertrophy during the onset of obesity precedes adipocyte dysfunction. One of the features of adipocyte dysfunction is dysregulated adipokine secretion, which leads to an imbalance of pro-inflammatory, pro-atherogenic versus anti-inflammatory, insulin-sensitizing adipokines. The production of renin-angiotensin system (RAS) components by adipocytes is exacerbated during obesity, contributing to the systemic RAS and its consequences. Increased adipose tissue RAS has been described in various models of diet-induced obesity (DIO) including fructose and high-fat feeding. Up-regulation of the adipose RAS by DIO promotes inflammation, lipogenesis and reactive oxygen species generation and impairs insulin signaling, all of which worsen the adipose environment. Consequently, the increase of circulating RAS, for which adipose tissue is partially responsible, represents a link between hypertension, insulin resistance in diabetes and inflammation during obesity. However, other nutrients and food components such as soy protein attenuate adipose RAS, decrease adiposity, and improve adipocyte functionality. Here, we review the molecular mechanisms by which adipose RAS modulates systemic RAS and how it is enhanced in obesity, which will explain the simultaneous development of metabolic syndrome alterations. Finally, dietary interventions that prevent obesity and adipocyte dysfunction will maintain normal RAS concentrations and effects, thus preventing metabolic diseases that are associated with RAS enhancement.
authors.affiliation: Mount Sinai Hospital, Toronto, ON, Canada M5G1X.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Frigolet
authors.forename: Nimbe
authors.initials: N
authors.lastname: Torres
authors.forename: Armando R
authors.initials: AR
authors.lastname: Tovar
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D050156:Adipogenesis; D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology* / Q000517:prevention & control; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D007328:Insulin
keywords: Adipocyte; Adipose tissue; Diabetes; Diet; Hypertension; Renin–angiotensin system