title: Epidemiological comparison of clinical manifestations according to HLA-B*27 carrier status of Chinese ankylosing spondylitis patients.
abstract: The aim of the study was to investigate and compare the clinical manifestations between HLA-B27(+) and HLA-B27(-) ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA-B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the status of HLA-B27 were collected using questionnaires and laboratory assay, respectively. A total of 2144 patients (78.5% males and 78.4% HLA-B27(+) AS patients) participated in this study. The percentages of males, patients with family history, and involvement of lumbar spine, thoracic spine and hip joints, were observed to be significantly higher in the HLA-B27(+) AS patients than in their HLA-B27(-) AS peers.
authors.affiliation: Department of Rheumatology and Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.forename: X
authors.initials: X
authors.lastname: Pan
authors.forename: Z
authors.initials: Z
authors.lastname: Hu
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Rong
authors.forename: J
authors.initials: J
authors.lastname: Zhai
authors.forename: P
authors.initials: P
authors.lastname: He
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.forename: H
authors.initials: H
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: F
authors.initials: F
authors.lastname: Zhan
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Gao
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Lin
authors.forename: Z
authors.initials: Z
authors.lastname: Liao
authors.forename: S
authors.initials: S
authors.lastname: Cao
authors.forename: Q
authors.initials: Q
authors.lastname: Wei
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Lv
authors.forename: J
authors.initials: J
authors.lastname: Qi
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: O
authors.initials: O
authors.lastname: Jin
authors.forename: Y
authors.initials: Y
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Gu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D003710:Demography; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000453:epidemiology* / Q000235:genetics*; D055815:Young Adult
chemical_list: D015796:HLA-B27 Antigen
keywords: HLA-B27; ankylosing spondylitis; clinical manifestations