title: Cycloartane triterpenes from Beesia calthaefolia (Maxim.).
abstract: Three new cycloartane triterpenoids (1-3) and two known compounds (4, 5) were isolated from the whole plant of Beesia calthaefolia. Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 4 showed stronger inhibitory activity (IC50 136.7 μM) than positive control (Rosmarinic acid, IC50 181.8 μM) while compounds 2 and 3 were moderately active with IC50 value of 206 μM and 200.9 μM. Chemical compound studied in this article: Rosmarinic acid (PubChem CID: 5281792).
authors.affiliation: Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mu
authors.affiliation: Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China; Tian Jin University of TCM, Tian jin 300193, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.
authors.forename: Dai-Hong
authors.initials: DH
authors.lastname: Guo
authors.affiliation: Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Zhao
authors.affiliation: Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China. Electronic address: liuping301@126.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D003167:Complement Activation / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D029626:Ranunculaceae / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D012503:Saponins
keywords: Anticomplement activity; Beesia calthaefolia; CP; Classical complement pathway; Cycloartane triterpene; ELSD; Evaporative light scattering detector; Ranunculaceae