title: [Influence of prenatal alcohol exposure on retinal development and cell differentiation].
abstract: The aim of the present study was to investigate the effects of prenatal alcohol exposure (PAE) on the development and cell differentiation of retina in offspring. The mouse model of PAE was made. HE staining and immunofluorescent labeling were carried out to visualize the structure, development and cell differentiation of the retina from postnatal day 0 (P0)-P30 offspring. The results showed that PAE can lead to the retardation of retinal development, the reduction of number of bipolar cells and horizontal cells, the disorder of horizontal cells' polarity, as well as the retinal thickening in a dose-dependent manner. The data suggest that alcohol exposure during pregnancy can lead to the developmental retardation of retina and decreased number of bipolar cells and horizontal cells in the retina of offspring.
authors.affiliation: Institute of Neurobiology, Henan University, Kaifeng 475004, China. jinbo_deng@henu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xi
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Wei-Fang
authors.initials: WF
authors.lastname: Kong
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Deng
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D012160:Retina / Q000166:cytology* / Q000187:drug effects*; D051245:Retinal Bipolar Cells / Q000187:drug effects; D051248:Retinal Horizontal Cells / Q000187:drug effects
chemical_list: D000431:Ethanol