title: Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats.
abstract: Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti-inflammatory effects. However, the mechanisms by which PPAR-γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR-γ ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate-induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high-lipid diet-induced hyperlipidemia and SAP.
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060;
authors.forename: Batur
authors.initials: B
authors.lastname: Niyaz
authors.forename: Kai-Liang
authors.initials: KL
authors.lastname: Zhao
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Deng
authors.forename: Teng
authors.initials: T
authors.lastname: Zuo
authors.forename: Qiao
authors.initials: Q
authors.lastname: Shi
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Wang
keywords: acute pancreatitis; cytokine; hyperlipidemia; peroxisome proliferator activated receptor-γ ligand