title: Loading dose of clopidogrel in combination with other antithrombotic therapy for capsular warning syndrome.
abstract: A 66-year-old man had repeated stereotypical transient ischemic attacks (TIAs) of dysarthria and left hemiparesis. His symptoms were considered capsular warning syndrome (CWS), for which the responsible lesion was found on magnetic resonance imaging to be in the right putamen expanding to the corona radiata. Although administration of antithrombotic therapy including aspirin was ineffective, no further TIAs occurred after a loading dose of clopidogrel was added. A loading dose of clopidogrel combined with other antithrombotic therapy might be an effective treatment for CWS.
authors.affiliation: Department of Neurology, Minamata City General Hospital and Medical Center, Minamata, Kumamoto, Japan; Department of Neurology, Saiseikai Kumamoto Hospital, Kumamoto, Japan. Electronic address: hkawanoo@gmail.com.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawano
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: Department of Neurology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Inatomi
authors.affiliation: Department of Neurology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yonehara
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D000368:Aged; D000077144:Clopidogrel; D038524:Diffusion Magnetic Resonance Imaging; D004359:Drug Therapy, Combination; D004401:Dysarthria / Q000209:etiology; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D018810:Magnetic Resonance Angiography; D008297:Male; D010291:Paresis / Q000209:etiology; D013577:Syndrome; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Antiplatelet; clopidogrel; stroke; transient ischemic attack