title: ACE inhibitors and angiotensin receptor blockers could promote the onset of endometrial polyps in hypertensive women.
abstract: OBJECTIVE
  To investigate whether anti-hypertensive therapy is a risk factor for the onset of endometrial polyps in hypertensive women.
  
  
  METHODS
  A sample of 305 hypertensive patients was analyzed. By applying multivariable logistic regression analysis, the odds of developing endometrial polyps relative to the known risk factors for endometrial polyps and to the class of anti-hypertensive drugs were calculated.
  
  
  RESULTS
  The variables reaching significance after multivariable logistic regression analysis included the following: hypertension not-in-therapy (odds ratio 2.544; 95% confidence intervals 1.249 - 5.182; p = 0.010); ACE inhibitor therapy (odds ratio 2.400; 95% confidence intervals 1.248 - 4.614; p = 0.009); angiotensin receptor blockers (odds ratio 2.091; 95% confidence intervals 1.044 - 4.187; p = 0.037); and fasting glucose level (odds ratio 1.018; 95% confidence intervals 1.007 - 1.030; p = 0.001).
  
  
  CONCLUSIONS
  Although the results should be interpreted carefully, it appears that ACE inhibitors and, to a lesser extent, angiotensin receptor blockers may promote the onset of endometrial polyps in hypertensive patients.
authors.forename: Ugo
authors.initials: U
authors.lastname: Indraccolo
authors.forename: Maria
authors.initials: M
authors.lastname: Matteo
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Greco
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Barbieri
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Mignini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016015:Logistic Models; D008875:Middle Aged; D011127:Polyps / Q000139:chemically induced*; D014591:Uterine Diseases / Q000139:chemically induced*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents