title: New biologically active hydrogen sulfide donors.
abstract: Generous donors: The dithioperoxyanhydrides (CH3 COS)2 , (PhCOS)2 , CH3 COSSCO2 Me and PhCOSSCO2 Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3 COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies.
authors.affiliation: UMR 8601, LCBPT, CNRS-Université Paris Descartes, PRES Sorbonne Paris Cité, 45 rue des Sts Pères, 75006 Paris (France).
authors.forename: Thomas
authors.initials: T
authors.lastname: Roger
authors.forename: Francoise
authors.initials: F
authors.lastname: Raynaud
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bouillaud
authors.forename: Céline
authors.initials: C
authors.lastname: Ransy
authors.forename: Serge
authors.initials: S
authors.lastname: Simonet
authors.forename: Christine
authors.initials: C
authors.lastname: Crespo
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Bourguignon
authors.forename: Nicole
authors.initials: N
authors.lastname: Villeneuve
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vilaine
authors.forename: Isabelle
authors.initials: I
authors.lastname: Artaud
authors.forename: Erwan
authors.initials: E
authors.lastname: Galardon
mesh_terms: D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D004220:Disulfides; D006862:Hydrogen Sulfide
keywords: SQR; biological activity; dithioperoxyanhydrides; hydrogen sulfide; oxidoreductases; vasorelaxation