title: The efficiency of functional brain networks does not differ between smokers and non-smokers.
abstract: Acute nicotine consumption in smokers impacts on functional brain network topology indicating an increase in the efficiency of information transfer and attentional task performance. The effects of chronic nicotine consumption on functional brain network topology are unknown. We here investigated the effects of chronic smoking-behaviour on functional brain network topology. Minimally-deprived smokers (N=18) and non-smokers (N=17) were measured within an fMRI scanner during a resting state condition. Graph-theoretical metrics of functional network integration (global efficiency and clustering) that have been shown to be affected by acute nicotine administration were compared between both groups. Our results revealed that smoking status did not significantly change functional network integration. Additional tests for non-inferiority confirmed the similarity of regional or nodal network properties. Brain regions such as the left insular and middle frontal gyrus, in which acute nicotine consumption affected network topology, did not reveal any decrease in functional network efficiency following chronic nicotine consumption. Within the limitation of the investigated sample size, our data suggest that the integration of functional brain networks is not altered in minimally-deprived smokers. Our findings are of relevance for clinical studies showing changes in network topology between psychiatric patients with high prevalence of smoking and healthy control subjects.
authors.affiliation: Biological Psychology Lab, Department of Psychology, Carl von Ossietzky University, Oldenburg, Germany. Electronic address: Thomas.breckel@uni-oldenburg.de.
authors.forename: Thomas Peer Karl
authors.initials: TP
authors.lastname: Breckel
authors.forename: Christiane Margarethe
authors.initials: CM
authors.lastname: Thiel
authors.forename: Carsten
authors.initials: C
authors.lastname: Giessing
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012146:Rest / Q000502:physiology; D018401:Sample Size; D012907:Smoking / Q000503:physiopathology; D014029:Tobacco Use Disorder; D055815:Young Adult
chemical_list: D009538:Nicotine
keywords: Brain efficiency; Equivalence testing; Graph theory; Resting state; Smoking addiction; fMRI