title: Cu(II)-catalyzed highly regio- and stereoselective construction of C-C double bonds: an efficient method for the ketonization-olefination of indoles.
abstract: A general and efficient method for the cross-coupling of indoles with β-keto esters by using TEMPO/CuSO4·5H2O in air as oxidant has been developed. This reaction features high functional-group compatibility and an excellent selectivity. This methodology provides an alternative approach for the ketonization-olefination of indoles in moderate to good yields.
authors.affiliation: Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. China. lxliu@xmu.edu.cn.
authors.forename: Yun-Hong
authors.initials: YH
authors.lastname: Bao
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Zhu
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Qin
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Kong
authors.forename: Zheng-Wang
authors.initials: ZW
authors.lastname: Chen
authors.forename: Shao-Bin
authors.initials: SB
authors.lastname: Tang
authors.forename: Liang-Xian
authors.initials: LX
authors.lastname: Liu
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003497:Cyclic N-Oxides; D004952:Esters; D007211:Indoles; D007659:Ketones; D003300:Copper; C003959:TEMPO