title: Interarytenoid botulinum toxin injection for recalcitrant vocal process granuloma.
abstract: OBJECTIVE
  This study evaluated the efficacy of botulinum toxin type A injected into the interarytenoid muscle to treat recalcitrant vocal process granulomas.
  
  
  METHODS
  Retrospective clinical review at a tertiary care center.
  
  
  METHODS
  Eight patients with vocal process granulomas refractory to a variety of prior treatments including surgical resection, proton pump inhibitor therapy, and voice therapy underwent percutaneous injection of botulinum toxin type A into the interarytenoid muscle, performed in an office setting. Doses ranged from 5 U to 25 U in one to two injections.
  
  
  RESULTS
  One patient demonstrated no improvement, two patients demonstrated partial resolution, and five patients demonstrated complete resolution of their granulomas. Four patients noted transient breathiness. There were no other side effects. All patients tolerated the injections without difficulty.
  
  
  CONCLUSIONS
  Botulinum toxin injection into the interarytenoid muscle appears to be a safe and effective modality for treating recalcitrant vocal process granuloma.
authors.affiliation: Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Fink
authors.forename: Jihad
authors.initials: J
authors.lastname: Achkar
authors.forename: Ramon A
authors.initials: RA
authors.lastname: Franco
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Song
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D006102:Granuloma, Laryngeal / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007273:Injections, Intramuscular; D007821:Laryngeal Muscles; D007828:Laryngoscopy; D012189:Retrospective Studies; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects*; D014833:Voice Quality / Q000187:drug effects*
chemical_list: D019274:Botulinum Toxins, Type A
keywords: Botulinum; botox; granuloma; vocal process