title: A prospective, randomized, controlled, multicenter evaluation of extraction socket preservation comparing two bovine xenografts: clinical and histologic outcomes.
abstract: The aim of this prospective, randomized, controlled, multicenter study was to evaluate and compare the histologic and histomorphometric aspects of extraction sockets grafted with two commercially available bovine bone xenografts: Endobon (test group) and Bio-Oss (control group). The study was designed to ensure that baseline variables between groups were as similar as possible to allow for a direct comparison of graft healing characteristics. Thirty-eight patients contributed 62 augmented extraction sites to the study. All sites were grafted with one type of bovine bone mineral and covered with a resorbable collagen membrane for 6 months of healing prior to implant placement surgery. The histologic outcomes between the two treatment groups are similar, with de novo bone (mean ± SD) for the test group at 28.5% ± 20% and for the control group, 31.4% ± 18%. Histologic specimens also include membrane remnants. All but two implants integrated successfully after 1 year of follow-up. This investigation provides support for the efficacy of bovine bone xenograft for socket preservation when subsequent implant placement is planned.
authors.forename: Antonio
authors.initials: A
authors.lastname: Barone
authors.forename: Marzio
authors.initials: M
authors.lastname: Todisco
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ludovichetti
authors.forename: Federico
authors.initials: F
authors.lastname: Gualini
authors.forename: Hans
authors.initials: H
authors.lastname: Aggstaller
authors.forename: Daniel
authors.initials: D
authors.lastname: Torrés-Lagares
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rohrer
authors.forename: Hari S
authors.initials: HS
authors.lastname: Prasad
authors.forename: James N
authors.initials: JN
authors.lastname: Kenealy
mesh_terms: D000328:Adult; D000818:Animals; D002417:Cattle; D064593:Heterografts; D006801:Humans; D011446:Prospective Studies; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome