title: Determination of perfluorochemicals in fish and shellfish using liquid chromatography-tandem mass spectrometry.
abstract: This paper reports the validation and application of a method for determination of 10 perfluorochemicals (PFCs) in retail fish and shellfish. The analytes of interest were 7 perfluorinated carboxylates and 3 perfluorinated sulfonates. Fish and shellfish samples were digested with a basic solution of 10 mM sodium hydroxide in methanol before sonication and solid phase extraction through weak anion exchange. Analysis was performed using liquid chromatography-tandem mass spectrometry. Recoveries from spiking five different types of fish and shellfish indicate that the method performs similarly with different fish types, and recoveries were over 90% for all analytes. Forty-six retail samples, collected between 2010 and 2012, including 13 different types of fish and shellfish were analyzed for PFCs. The 13 different types included the top 10 most-consumed fish and shellfish in the United States according to data collected by the National Fisheries Institute. Two Standard Reference Materials were also analyzed. Most fish and shellfish had no detected PFCs; only 11 samples of the 46 tested had detectable concentrations of PFCs.
authors.affiliation: Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, HFS 706, College Park, Maryland 20740, United States.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Young
authors.forename: Paul
authors.initials: P
authors.lastname: South
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Begley
authors.forename: Gregory O
authors.initials: GO
authors.lastname: Noonan
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005399:Fishes; D005466:Fluorocarbons / Q000737:chemistry*; D005506:Food Contamination / Q000032:analysis*; D008460:Meat / Q000032:analysis*; D017747:Seafood / Q000032:analysis*; D012758:Shellfish / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000737:chemistry
chemical_list: D005466:Fluorocarbons; D014874:Water Pollutants, Chemical