title: Neo-adjuvant chemotherapy for cervical cancer in pregnancy: a case report and literature review.
abstract: Managing women who are pregnant and with a diagnosis of cervical cancer has many complex challenges. This case report describes the diagnosis and management of a patient presenting in her first trimester with stage 2B cervical cancer. In conjunction with this a literature review was undertaken using the following databases from the years 1970-2010: Embase, CINAHL, Medline and DARE. We examined the number of cases reported in the literature in which chemotherapy also was used in pregnant women with a cervical malignancy. Twenty-four papers were retrieved describing in total (including the present case) 35 cases of cervical cancer in pregnancy treated with this modality. Cisplatin therapy would seem the most reliable form of treatment, permitting a good outcome for most patients. The effect of delaying radiotherapy to permit pregnancy to fetal viability in larger tumours cannot be elucidated.
authors.affiliation: Horton Hospital Oxford Radcliffe University NHS Trust, OX16 9AL Oxford, UK. Electronic address: rehana_dawood@yahoo.com.
authors.forename: Rehana
authors.initials: R
authors.lastname: Dawood
authors.forename: Margaret
authors.initials: M
authors.lastname: Instone
authors.forename: Sean
authors.initials: S
authors.lastname: Kehoe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000532:radiotherapy; D011261:Pregnancy Trimester, First; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D002945:Cisplatin
keywords: Cervical cancer; Chemotherapy; Neo-adjuvant chemotherapy and radiotherapy; Pregnancy