title: A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection.
abstract: Plasmablastic lymphoma (PBL) is a very rare B-cell lymphoproliferative disorder was with an aggressive clinical behavior that recently characterized by the World Health Organization. Although PBL is most commonly observed in the oral cavity of human immunodeficiency virus (HIV)-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. Epstein-Barr virus (EBV) may be closely related the pathogenesis of PBL. PBL shows different clinicopathological characteristics between HIV-positive and -negative patients. Here, we report a case of PBL of the liver in a 79-year-old HIV-negative male. The patient died approximately 1.5 mo after examination and autopsy showed that the main lesion was a very large liver mass. Histopathological examination of the excised lesion showed large-cell lymphoma with plasmacytic differentiation diffusely infiltrating the liver and involving the surrounding organs. The neoplastic cells were diffusely positive for CD30, EBV, Bob-1, and CD38. The autopsy findings suggested a diagnosis of PBL. To our knowledge, the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection.
authors.affiliation: Joji Tani, Hisaaki Miyoshi, Takako Nomura, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761-0793, Japan.
authors.forename: Joji
authors.initials: J
authors.lastname: Tani
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Takako
authors.initials: T
authors.lastname: Nomura
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yoneyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobara
authors.forename: Hirohito
authors.initials: H
authors.lastname: Mori
authors.forename: Asahiro
authors.initials: A
authors.lastname: Morishita
authors.forename: Takashi
authors.initials: T
authors.lastname: Himoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masaki
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D010166:Palliative Care; D014057:Tomography, X-Ray Computed; D015534:Trans-Activators / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; D008562:Membrane Glycoproteins; C091546:POU2AF1 protein, human; D015534:Trans-Activators; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1
keywords: Human immunodeficiency virus-negative; Immunohistochemistry; Normal liver; Pathogenesis; Plasmablastic lymphoma