title: Dose-depending effect of intracerebroventricularly administered bradykinin on nociception in rats.
abstract: BACKGROUND
  The effect of small and high doses of intracerebroventricularly (icv) applied bradykinin (BK) on nociception produced by mechanical stimuli and the participation of B1 and B2 receptors in this nociception were investigated in rats.
  
  
  RESULTS
  BK at the lowest dose (0.06 μg) produced hyperalgesia whereas at the higher doses (6 and 12 μg) antinociception. This effect was abolished by B1 or B2 receptor antagonists, des-Arg(10)-HOE140 and HOE140 (1 pmol icv), respectively.
  
  
  CONCLUSIONS
  Depending on the dose used, BK produces pro- or anti-nociceptive action. Both B1 and B2 receptors are involved in the action of icv applied BK.
authors.affiliation: Department of Pharmacodynamics, Medical University of Warsaw, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa 64, P.O. Box 3, Poland. mbujalska@gmail.com.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bujalska-Zadrożny
authors.forename: Anna
authors.initials: A
authors.lastname: de Cordé
authors.forename: Krystyna
authors.initials: K
authors.lastname: Cegielska-Perun
authors.forename: Emilia
authors.initials: E
authors.lastname: Gąsińska
authors.forename: Helena
authors.initials: H
authors.lastname: Makulska-Nowak
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D065169:Bradykinin B1 Receptor Antagonists; D065094:Bradykinin B2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000139:chemically induced; D057967:Infusions, Intraventricular; D008297:Male; D059225:Nociception / Q000187:drug effects*; D051381:Rats; D043783:Receptor, Bradykinin B1 / Q000819:agonists; D043782:Receptor, Bradykinin B2 / Q000819:agonists; D044005:Tetrahydroisoquinolines / Q000494:pharmacology
chemical_list: D065169:Bradykinin B1 Receptor Antagonists; D065094:Bradykinin B2 Receptor Antagonists; D043783:Receptor, Bradykinin B1; D043782:Receptor, Bradykinin B2; D044005:Tetrahydroisoquinolines; C078665:HOE 140, desArg(10)-; C065679:icatibant; D001920:Bradykinin