title: Dramatic shift in the infantile hemangioma treatment paradigm at a single institution.
abstract: Historically the first line of treatment for infantile hemangiomas (IHs) has been oral corticosteroids, but because of recent discoveries recognizing the effectiveness of oral and topical beta-blockers, IH management is dynamically changing. With these new treatment options, some physicians are altering the way they manage IHs despite having little evidence-based data on the treatment methods. Highlighting treatment changes at a single large tertiary pediatric referral center, we conclude that despite the numerous studies already published on this topic, more reliable prospective studies are needed to determine the safety, efficacy, and best treatment algorithms for the use of topical and oral beta-blockers for the treatment of IHs.
authors.affiliation: Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gomulka
authors.forename: Dawn H
authors.initials: DH
authors.lastname: Siegel
authors.forename: Beth A
authors.initials: BA
authors.lastname: Drolet
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000465:Algorithms; D016208:Databases, Factual; D019317:Evidence-Based Medicine / Q000639:trends*; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D012878:Skin Neoplasms / Q000188:drug therapy*; D062606:Tertiary Care Centers
chemical_list: D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists