title: Cyclic 3-alkyl pyridinium alkaloid monomers from a New Zealand Haliclona sp. marine sponge.
abstract: Bioassay and NMR approaches have been used to guide the isolation of one known and two new cyclic 3-alkyl pyridinium alkaloid (3-APA) monomers from the New Zealand marine sponge Haliclona sp. The new compounds, dehydrohaliclocyclins C (3) and F (4), are the first reported examples of cyclic 3-APA monomers with unsaturation in the alkyl chain. The known compound haliclocyclin C (2) was also isolated from a mixture with 4. The structures of compounds 2-4 were elucidated using NMR spectroscopy, mass spectrometry, and chemical degradation.
authors.affiliation: Centre for Biodiscovery and School of Chemical & Physical Sciences, Victoria University of Wellington , PO Box 600, Kelburn, Wellington 6140, New Zealand.
authors.forename: Vidhiya
authors.initials: V
authors.lastname: Damodaran
authors.forename: Jason L
authors.initials: JL
authors.lastname: Ryan
authors.forename: Robert A
authors.initials: RA
authors.lastname: Keyzers
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D047129:Haliclona / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011726:Pyridinium Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D011726:Pyridinium Compounds; C585389:dehydrohaliclocyclin C; C585388:dehydrohaliclocyclin F