title: Endogenous 4β-hydroxycholesterol-to-cholesterol ratio is not a validated biomarker for the assessment of CYP3A activity.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (J.D.M.); and Bertino Consulting, Schenectady, New York (A.N.N., J.S.B.).
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Ma
authors.forename: Anne N
authors.initials: AN
authors.lastname: Nafziger
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Bertino
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006888:Hydroxycholesterols / Q000378:metabolism*; D008297:Male; D008874:Midazolam / Q000493:pharmacokinetics*; D012293:Rifampin / Q000494:pharmacology*
chemical_list: D006888:Hydroxycholesterols; D051544:Cytochrome P-450 CYP3A; D008874:Midazolam; D012293:Rifampin