title: Effect of pegylated hyaluronate-endo-β-N-acetylhexosaminidase on humoral mechanisms regulating the functions of progenitor cells during chronic hepatitis.
abstract: We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management Company, Novosibirsk, Russia. zgn@pharm.tsu.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: D N
authors.initials: DN
authors.lastname: Kinsht
authors.forename: A V
authors.initials: AV
authors.lastname: Artamonov
authors.forename: A A
authors.initials: AA
authors.lastname: Bekarev
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism*; D002465:Cell Movement / Q000187:drug effects; D060833:Cellular Microenvironment / Q000187:drug effects; D054377:Chemokine CXCL12 / Q000096:biosynthesis*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000494:pharmacology*
chemical_list: C575935:CXCL12 protein, rat; D054377:Chemokine CXCL12; D011092:Polyethylene Glycols; D006821:Hyaluronoglucosaminidase; D001619:beta-N-Acetylhexosaminidases; C584942:pegylated hyaluronate-endo-beta-N-acetylhexosaminidase