title: Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers.
abstract: BACKGROUND
  Health authorities of Kazakhstan are seeking for effective measures to interrupt the untoward trend, projected to increase the current number of gastric cancer (GC) cases (n=3,316) by 50% until the year 2030.
  
  
  OBJECTIVE
  Use of a non-invasive blood test with four stomach-specific biomarkers [Pepsinogen-I (PG-I) and -II (PG-II), amidated gastrin-17 (G-17), and Helicobacter pylori (HP) IgG antibodies], to assess for the prevalence of stomach conditions: Helicobacter pylori (HP) infection and atrophic gastritis (AG), both known to increase GC risk of in Kazakhstan.
  
  
  METHODS
  A cohort of 835 (symptomatic and asymptomatic) cases (473 women and 362 men)(median age 46.8 years; range 13.6-74.8) was examined with a panel of biomarkers. Results were assigned in five categories: 1) Healthy stomach, 2) HP infection, 3) atrophic gastritis (AG) of the antrum, 4) AG of the corpus, and 5) AG of both antrum and corpus (pangastritis).
  
  
  RESULTS
  The distribution in these five categories was identical in both sexes (p=0.259). Healthy stomach was detected only in 196 (23.5%) subjects, whereas the vast majority, 62.3% (n=519) had HP infection (with no AG). In 118 (14.1%) subjects, results were consistent with AG; in antrum (n=72), corpus (n=42) or pangastritis (n=4). Prevalence of AG increased with patient's age in both sexes. There was no age-related pattern in biomarker levels, and only slight differences between the genders.
  
  
  CONCLUSIONS
  While capable of detecting the subjects at risk for GC (HP or AG), GP seems to be a cost-effective means to intervene the current ominous trend in GC incidence in Kazakhstan.
authors.affiliation: Department of Gastroenterology, Astana Medical University. 49, Beybitshilik Str., 010000 Astana, Kazakhstan. rbektaeva@bk.ru.
authors.forename: Valery
authors.initials: V
authors.lastname: Benberin
authors.forename: Roza
authors.initials: R
authors.lastname: Bektayeva
authors.forename: Raushan
authors.initials: R
authors.lastname: Karabayeva
authors.forename: Aleksandr
authors.initials: A
authors.lastname: Lebedev
authors.forename: Kenzhekhan
authors.initials: K
authors.lastname: Akemeyeva
authors.forename: Lea
authors.initials: L
authors.lastname: Paloheimo
authors.forename: Kari
authors.initials: K
authors.lastname: Syrjänen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004415:Dyspepsia / Q000097:blood* / Q000453:epidemiology; D005260:Female; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016481:Helicobacter Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007623:Kazakhstan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D020115:Pepsinogen C / Q000097:blood; D010641:Phenotype; D015995:Prevalence; D017678:Sex Distribution; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D005755:Gastrins; C013550:gastrin 17; D020115:Pepsinogen C; D020116:Pepsinogen A
keywords: Gastric cancer; Helicobacter pylori; achlorhydria; antrum; atrophic gastritis; biomarker panel; blood test; corpus; gastrin-17; pepsinogens; risk factors