title: Cloning and sequencing of the chaetocin biosynthetic gene cluster.
abstract: How a fungus does it: The epidithiodiketopiperazine (ETP) fungal alkaloids, which include gliotoxin, have garnered much attention since their initial isolation. The cloning and sequencing of the biosynthetic gene cluster for another ETP, chaetocin A were used to suggest a route towards dimerization and sulfur incorporation in these molecules.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115 (USA); Current address: Metanomics GmbH, Tegeler Weg 33, 10589 Berlin (Germany).
authors.forename: Thomas
authors.initials: T
authors.lastname: Gerken
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Walsh
mesh_terms: D001483:Base Sequence; D053898:Biosynthetic Pathways / Q000235:genetics*; D002597:Chaetomium / Q000235:genetics* / Q000378:metabolism*; D003001:Cloning, Molecular; D005810:Multigene Family / Q000235:genetics*; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism
chemical_list: D010879:Piperazines; C002511:chaetocin
keywords: alkaloids; biosynthesis; chaetocin; epidithiodiketopiperazine; gliotoxin