title: Central nervous system manifestations of neonatal lupus: a systematic review.
abstract: Neonatal lupus is a rare and acquired autoimmune disease. Central nervous system abnormalities are potential manifestations in neonatal lupus. Through a systematic literature review, we analyzed the clinical features of previously reported neonatal lupus cases where central nervous system abnormalities had been identified. Most reported neonatal lupus patients with central nervous system involvement were neuroimaging-determined and asymptomatic. Only seven neonatal lupus cases were identified as having a symptomatic central nervous system abnormality which caused physical disability or required neurosurgery. A high percentage of these neurosymptomatic neonatal lupus patients had experienced a transient cutaneous skin rash and had no maternal history of autoimmune disease before pregnancy.
authors.affiliation: 1Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: K-L
authors.initials: KL
authors.lastname: Lin
authors.forename: C-L
authors.initials: CL
authors.lastname: Chen
authors.forename: A May-Kuen
authors.initials: AM
authors.lastname: Wong
authors.forename: J-L
authors.initials: JL
authors.lastname: Huang
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000503:physiopathology; D020945:Lupus Vasculitis, Central Nervous System / Q000151:congenital / Q000503:physiopathology* / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods; D011247:Pregnancy
keywords: Neonate; autoimmune disease; central nervous system; neonatal lupus