title: Epigenetics and cancer metabolism.
abstract: Cancer cells adapt their metabolism to support proliferation and survival. A hallmark of cancer, this alteration is characterized by dysfunctional metabolic enzymes, changes in nutrient availability, tumor microenvironment and oncogenic mutations. Metabolic rewiring in cancer is tightly connected to changes at the epigenetic level. Enzymes that mediate epigenetic status of cells catalyze posttranslational modifications of DNA and histones and influence metabolic gene expression. These enzymes require metabolites that are used as cofactors and substrates to carry out reactions. This interaction of epigenetics and metabolism constitutes a new avenue of cancer biology and could lead to new insights for the development of anti-cancer therapeutics.
authors.affiliation: Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States.
authors.forename: Christelle
authors.initials: C
authors.lastname: Johnson
authors.affiliation: Systems Bioinformatics/AIMMS, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands; Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Marc O
authors.initials: MO
authors.lastname: Warmoes
authors.affiliation: Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY, United States.
authors.forename: Xiling
authors.initials: X
authors.lastname: Shen
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. Electronic address: Locasale@cornell.edu.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Locasale
mesh_terms: D049109:Cell Proliferation; D002952:Citric Acid Cycle / Q000502:physiology; D019175:DNA Methylation / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics; D044127:Epigenesis, Genetic; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D011499:Protein Processing, Post-Translational / Q000235:genetics; D059016:Tumor Microenvironment
chemical_list: D005947:Glucose
keywords: Amino acid metabolism; Cancer; Epigenetics; Glucose flux; Metabolism