title: Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.
abstract: OBJECTIVE
  The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice.
  
  
  RESULTS
  Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members, which results in the activation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a major factor that controls mitochondrial biogenesis and respiration, as well as superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stress markers, including protein carbonyls, apurinic/apyrimidinic sites, malondialdehydes, and increase the reduced glutathione/oxidized glutathione ratio. Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1α by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).
  
  
  CONCLUSIONS
  These results show that ubiquinol-10 may enhance mitochondrial activity by increasing levels of SIRT1, PGC-1α, and SIRT3 that slow the rate of age-related hearing loss and protect against the progression of aging and symptoms of age-related diseases.
authors.affiliation: 1 Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine , Matsumoto, Japan .
authors.forename: Geng
authors.initials: G
authors.lastname: Tian
authors.forename: Jinko
authors.initials: J
authors.lastname: Sawashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kubo
authors.forename: Shin-ya
authors.initials: SY
authors.lastname: Nishio
authors.forename: Shigenari
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Suzuki
authors.forename: Hidekane
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Mineko
authors.initials: M
authors.lastname: Tsuruoka
authors.forename: Yaoyong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yingye
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongming
authors.initials: H
authors.lastname: Luo
authors.forename: Zhe
authors.initials: Z
authors.lastname: Xu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mori
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Kitano
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hosoe
authors.forename: Toshio
authors.initials: T
authors.lastname: Takeda
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Usami
authors.forename: Keiichi
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000107:Acetylation / Q000187:drug effects; D000375:Aging / Q000187:drug effects*; D000818:Animals; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010766:Phosphorylation / Q000187:drug effects; D011494:Protein Kinases / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D008565:Membrane Proteins; D009687:Nuclear Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C575109:Samp1 protein, mouse; D014157:Transcription Factors; D014451:Ubiquinone; C026663:ubiquinol-10; D011494:Protein Kinases; D000091162:AMP-Activated Protein Kinase Kinases; C447939:SIRT1 protein, human; D056564:Sirtuin 1