title: Hypolipemic effect of Garcinia cambogia in obese women.
abstract: Garcinia cambogia seems to promote weight reduction and improvement on lipid profile by its major compound, hydroxycitric acid (HCA), blocking ATP-citratelyase, potentially inhibiting lipogenesis. Furthermore, it is suggested that its extract is able to change the adipokine levels. Thus, the aim of this study was to analyse the effect of G. cambogia on the lipid profile, endocrine, calorimetric and anthropometric parameters of obese women. The women (BMI > 25 kg/m(2) ; age 25-60 years), divided in treated (n = 30) and control (n = 13) groups, received 2.4 g (800 mg 3×/day) of garcinia extract (50% of HCA) or placebo during 60 days, respectively, as well as dietary control. Weight, BMI, waist-hip ratio and percentage of fat mass, resting metabolic rate, respiratory coefficient, triglycerides (TG), total cholesterol, HDL and LDL, leptin and insulin serum levels were evaluated. TG was significantly reduced in the treated group (p = 0.0002) and the post-treatment variation was different compared to the placebo group (p = 0.04). No significant response was observed on other variables of the lipid profile, or on the anthropometric and calorimetric parameters. Leptin and insulin levels did not change significantly after the treatment. The short-term treatment with G. cambogia demonstrated a hypotriglyceridemic effect, which does not appear to be related to changes in leptinemia.
authors.affiliation: Grupo de pesquisa em saúde humana e ambiente, Instituto de Ciências da Saúde, Universidade Feevale, RS-239, 2755, 93352-000, Novo Hamburgo, Rio Grande do Sul, Brasil.
authors.forename: Carlos A R
authors.initials: CA
authors.lastname: Vasques
authors.forename: Ricardo
authors.initials: R
authors.lastname: Schneider
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Klein-Júnior
authors.forename: Andressa
authors.initials: A
authors.lastname: Falavigna
authors.forename: Ivone
authors.initials: I
authors.lastname: Piazza
authors.forename: Simone
authors.initials: S
authors.lastname: Rossetto
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D029761:Garcinia cambogia / Q000737:chemistry*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010936:Plant Extracts / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D007328:Insulin; D020738:Leptin; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: Garcinia cambogia; leptin; lipid profile; obesity