title: Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
abstract: Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape.
authors.affiliation: Genentech, Inc, South San Francisco, CA, 94080, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Bates
authors.forename: Lauri
authors.initials: L
authors.lastname: Diehl
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D003424:Crohn Disease / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D055808:Drug Discovery; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D007422:Intestines / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D058990:Molecular Targeted Therapy
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents
keywords: Crohn's disease; colitis; dendritic cell; inflammation; inflammatory bowel disease; mucosal immunity