title: Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.
abstract: OBJECTIVE
  Hospital-level variations in structure and process may affect clinical outcomes in ICUs. We sought to characterize the organizational structure, processes of care, use of protocols, and standardized outcomes in a large sample of U.S. ICUs.
  
  
  METHODS
  We surveyed 69 ICUs about organization, size, volume, staffing, processes of care, use of protocols, and annual ICU mortality.
  
  
  METHODS
  ICUs participating in the United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.
  
  
  METHODS
  Sixty-nine intensivists completed the survey.
  
  
  RESULTS
  We characterized structure and process variables across ICUs, investigated relationships between these variables and annual ICU mortality, and adjusted for illness severity using Acute Physiology and Chronic Health Evaluation II. Ninety-four ICU directors were invited to participate in the study and 69 ICUs (73%) were enrolled, of which 25 (36%) were medical, 24 (35%) were surgical, and 20 (29%) were of mixed type, and 64 (93%) were located in teaching hospitals with a median number of five trainees per ICU. Average annual ICU mortality was 10.8%, average Acute Physiology and Chronic Health Evaluation II score was 19.3, 58% were closed units, and 41% had a 24-hour in-house intensivist. In multivariable linear regression adjusted for Acute Physiology and Chronic Health Evaluation II and multiple ICU structure and process factors, annual ICU mortality was lower in surgical ICUs than in medical ICUs (5.6% lower [95% CI, 2.4-8.8%]) or mixed ICUs (4.5% lower [95% CI, 0.4-8.7%]). We also found a lower annual ICU mortality among ICUs that had a daily plan of care review (5.8% lower [95% CI, 1.6-10.0%]) and a lower bed-to-nurse ratio (1.8% lower when the ratio decreased from 2:1 to 1.5:1 [95% CI, 0.25-3.4%]). In contrast, 24-hour intensivist coverage (p = 0.89) and closed ICU status (p = 0.16) were not associated with a lower annual ICU mortality.
  
  
  CONCLUSIONS
  In a sample of 69 ICUs, a daily plan of care review and a lower bed-to-nurse ratio were both associated with a lower annual ICU mortality. In contrast to 24-hour intensivist staffing, improvement in team communication is a low-cost, process-targeted intervention strategy that may improve clinical outcomes in ICU patients.
authors.affiliation: 1Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD. 2Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, GA. 3Division of Pulmonary and Critical Care, Intermountain Medical Center and University of Utah, Salt Lake City, UT. 4Division of Pulmonary and Critical Care, University of Medicine and Dentistry of New Jersey, Newark, NJ. 5Division of Pulmonary, Critical Care, and Environmental Medicine, University of Missouri-Columbia, Columbia, MO. 6Division of Pulmonary and Critical Care, Meharry Medical College, Nashville, TN. 7Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN. 8Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. 9Department of Surgical Critical Care, University of Maryland, Baltimore, MD. 10Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Cleveland, OH. 11Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI. 12Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY. 13Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. 14Division of Pulmonary and Critical Care Medicine, University of Rochester, Rochester, NY. 15INOVA Fairfax Hospital, Falls Church, VA. 16Suburban Hospital, Bethesda, MD. 17Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT. 18Department of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA.
authors.forename: William
authors.initials: W
authors.lastname: Checkley
authors.forename: Greg S
authors.initials: GS
authors.lastname: Martin
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Brown
authors.forename: Steven Y
authors.initials: SY
authors.lastname: Chang
authors.forename: Ousama
authors.initials: O
authors.lastname: Dabbagh
authors.forename: Richard D
authors.initials: RD
authors.lastname: Fremont
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Girard
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rice
authors.forename: Michael D
authors.initials: MD
authors.lastname: Howell
authors.forename: Steven B
authors.initials: SB
authors.lastname: Johnson
authors.forename: James
authors.initials: J
authors.lastname: O'Brien
authors.forename: Pauline K
authors.initials: PK
authors.lastname: Park
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Pastores
authors.forename: Namrata T
authors.initials: NT
authors.lastname: Patil
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Pietropaoli
authors.forename: Maryann
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authors.lastname: Putman
authors.forename: Leo
authors.initials: L
authors.lastname: Rotello
authors.forename: Jonathan
authors.initials: J
authors.lastname: Siner
authors.forename: Sahul
authors.initials: S
authors.lastname: Sajid
authors.forename: David J
authors.initials: DJ
authors.lastname: Murphy
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Sevransky
mesh_terms: D018806:APACHE; D016638:Critical Illness; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration*; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D014481:United States; D014947:Wounds and Injuries / Q000401:mortality*