title: A path forward for the chlamydial virulence factor CPAF.
abstract: CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
authors.forename: Turner
authors.initials: T
authors.lastname: A Conrad
authors.forename: Zhangsheng
authors.initials: Z
authors.lastname: Yang
authors.forename: David
authors.initials: D
authors.lastname: Ojcius
authors.forename: Guangming
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000818:Animals; D002689:Chlamydia / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D037521:Virulence Factors / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D037521:Virulence Factors; D010450:Endopeptidases; C425923:CPA factor
keywords: CPAF; Chlamydial virulence factors and pathogenesis; Substrates