title: Relationship of blood levels of inflammatory and destructive biomarkers in coronary atherosclerosis with long-term results of surgical revascularization.
abstract: The relationships between blood levels of inflammatory and destructive biomarkers (TNF-α, IL-1β, IL-6, IL-8, soluble CD40 ligand, high-sensitivity C-reactive protein, endothelial adhesion molecules, matrix metalloproteinase 3 and 9 and their tissue inhibitor type 1) were studied in men with coronary atherosclerosis before and 5 years after coronary artery bypass surgery. In men with unfavorable course of coronary atherosclerosis in the delayed period, the initial blood levels of C-reactive protein and TNF-α by 1.7 and 3.0 times surpassed those in patients with favorable course of the disease. Associations were revealed between elevated blood content of high-sensitivity C-reactive protein (p=0.01, odds ratio of 1.33) and IL-8 (p=0.02, odds ratio of 1.02) and deaths in the delayed period; IL-6 (p=0.01, odds ratio of 1.02) and cases of myocardial infarction; C-reactive protein (p=0.02, odds ratio of 1.24) and unfavorable course of the delayed period in general (death, myocardial infarction, worsening of angina pectoris functional class).
authors.affiliation: Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk; E. N. Meshalkin Research Institute of Circulatory Pathology, Ministry of Health and Social Development of the Russian Federation, Novosibirsk, Russia. ragino@mail.ru.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.forename: A M
authors.initials: AM
authors.lastname: Chernyavskiy
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tsimbal
authors.forename: L V
authors.initials: LV
authors.lastname: Shcherbakova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Polonskaya
authors.forename: E V
authors.initials: EV
authors.lastname: Kashtanova
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D012426:Russia; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers