title: Aortic intima-media thickness measured by trans-abdominal ultrasound as an early life marker of subclinical atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory process that begins in early life. Improved identification of markers of early atherosclerosis via neonatal aortic intima-media thickness (aIMT) measurement may allow the development of interventions to prevent or reduce later cardiovascular disease.
  
  
  CONCLUSIONS
  Using aIMT, studies have shown that antenatal factors such as intra-uterine growth retardation, prematurity, maternal factors and inflammation are associated with early cardiovascular changes.
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Vic., Australia; Child Health Research Unit, Barwon Health, Geelong, Vic., Australia; University of Melbourne, Parkville, Vic., Australia.
authors.forename: Kate
authors.initials: K
authors.lastname: McCloskey
authors.forename: Peter
authors.initials: P
authors.lastname: Vuillermin
authors.forename: Anne-Louise
authors.initials: AL
authors.lastname: Ponsonby
authors.forename: Michael
authors.initials: M
authors.lastname: Cheung
authors.forename: Michael R
authors.initials: MR
authors.lastname: Skilton
authors.forename: David
authors.initials: D
authors.lastname: Burgner
mesh_terms: D001011:Aorta / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D015415:Biomarkers; D059168:Carotid Intima-Media Thickness; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000033:anatomy & histology / Q000000981:diagnostic imaging
chemical_list: D015415:Biomarkers
keywords: Aorta; Atherosclerosis; Cardiovascular; Intima-media; Neonatal