title: The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis.
abstract: We investigated the impact of disease duration, clinical course and immunosuppressive therapy on intrathecal IgG synthesis in multiple sclerosis (MS). Cerebrospinal fluid (CSF) was obtained twice, 8-10 years apart, from 20 MS patients and 26 healthy controls, and from 22 MS patients before and after two years of mitoxantrone treatment. The oligoclonal IgG band patterns changed in 15 patients at long-term follow-up, but were only influenced in 4 patients by mitoxantrone therapy. The CSF B-cell-regulating chemokine CXCL13 correlated with intrathecal IgG production suggesting a B-cell-dependence of intrathecal IgG synthesis in MS.
authors.affiliation: Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: markus.axelsson@vgregion.se.
authors.forename: Markus
authors.initials: M
authors.lastname: Axelsson
authors.forename: Niklas
authors.initials: N
authors.lastname: Mattsson
authors.forename: Clas
authors.initials: C
authors.lastname: Malmeström
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Jan
authors.initials: J
authors.lastname: Lycke
mesh_terms: D000293:Adolescent; D000328:Adult; D054382:Chemokine CXCL13 / Q000378:metabolism; D004185:Disability Evaluation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007278:Injections, Spinal; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D054382:Chemokine CXCL13; D043025:Oligoclonal Bands; D008942:Mitoxantrone
keywords: B-cell; CXCL13; Intrathecal IgG; Mitoxantrone; Multiple sclerosis; Oligoclonal band (OCB)