title: Genome-wide association study of atypical psychosis.
abstract: Atypical psychosis with a periodic course of exacerbation and features of major psychiatric disorders [schizophrenia (SZ) and bipolar disorder (BD)] has a long history in clinical psychiatry in Japan. Based upon the new criteria of atypical psychosis, a Genome-Wide Association Study (GWAS) was conducted to identify the risk gene or variants. The relationships between atypical psychosis, SZ and BD were then assessed using independent GWAS data. Forty-seven patients with solid criteria of atypical psychosis and 882 normal controls (NCs) were scanned using an Affymetrics 6.0 chip. GWAS SZ data (560 SZ cases and 548 NCs) and GWAS BD (107 cases with BD type 1 and 107 NCs) were compared using gene-based analysis. The most significant SNPs were detected around the CHN2/CPVL genes (rs245914, P = 1.6 × 10(-7)) , COL21A1 gene (rs12196860, P = 2.45 × 10(-7) ), and PYGL/TRIM9 genes (rs1959536, P = 7.73 × 10(-7) ), although none of the single-nucleotide polymorphisms exhibited genome-wide significance (P = 5 × 10(-8) ). One of the highest peaks was detected on the major histocompatibility complex region, where large SZ GWASs have previously disclosed an association. The gene-based analysis suggested significant enrichment between SZ and atypical psychosis (P = 0.01), but not BD. This study provides clues about the types of patient whose diagnosis lies between SZ and BD. Studies with larger samples are required to determine the causal variant.
authors.affiliation: Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka, Japan; Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Glatt
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsutsumi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kikuyama
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Nao
authors.initials: N
authors.lastname: Nishida
authors.forename: Taku
authors.initials: T
authors.lastname: Miyagawa
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Jun
authors.initials: J
authors.lastname: Koh
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoneda
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D012984:Software
chemical_list: D005819:Genetic Markers
keywords: GWAS; acute and transient psychotic disorder; atypical psychosis; bipolar disorder; schizophrenia