title: Adiponectin: an attractive marker for metabolic disorders in Chronic Obstructive Pulmonary Disease (COPD).
abstract: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease which may be complicated by development of co-morbidities including metabolic disorders. Metabolic disorders commonly associated with this disease contribute to lung function impairment and mortality. Systemic inflammation appears to be a major factor linking COPD to metabolic alterations. Adipose tissue seems to interfere with systemic inflammation in COPD patients by producing a large number of proteins, known as "adipokines", involved in various processes such as metabolism, immunity and inflammation. There is evidence that adiponectin is an important modulator of inflammatory processes implicated in airway pathophysiology. Increased serum levels of adiponectin and expression of its receptors on lung tissues of COPD patients have recently highlighted the importance of the adiponectin pathway in this disease. Further, in vitro studies have demonstrated an anti-inflammatory activity for this adipokine at the level of lung epithelium. This review focuses on mechanisms by which adiponectin is implicated in linking COPD with metabolic disorders.
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Loc. Tappino, Campobasso 86100, Italy. andrea.bianco@unimol.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bianco
authors.forename: Gennaro
authors.initials: G
authors.lastname: Mazzarella
authors.forename: Viviana
authors.initials: V
authors.lastname: Turchiarelli
authors.forename: Ersilia
authors.initials: E
authors.lastname: Nigro
authors.forename: Graziamaria
authors.initials: G
authors.lastname: Corbi
authors.forename: Olga
authors.initials: O
authors.lastname: Scudiero
authors.forename: Matteo
authors.initials: M
authors.lastname: Sofia
authors.forename: Aurora
authors.initials: A
authors.lastname: Daniele
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D015897:Comorbidity; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008659:Metabolic Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers