title: Quantification of primary motor pathways using diffusion MRI tractography and its application to predict postoperative motor deficits in children with focal epilepsy.
abstract: As a new tool to quantify primary motor pathways and predict postoperative motor deficits in children with focal epilepsy, the present study utilized a maximum a posteriori probability (MAP) classification of diffusion weighted imaging (DWI) tractography combined with Kalman filter. DWI was performed in 31 children with intractable focal epilepsy who underwent epilepsy surgery. Three primary motor pathways associated with "finger," "leg," and "face" were classified using DWI-MAP classifier and compared with the results of invasive electrical stimulation mapping (ESM) via receiver operating characteristic (ROC) curve analysis. The Kalman filter analysis was performed to generate a model to determine the probability of postoperative motor deficits as a function of the proximity between the resection margin and the finger motor pathway. The ROC curve analysis showed that the DWI-MAP achieves high accuracy up to 89% (finger), 88% (leg), 89% (face), in detecting the three motor areas within 20 mm, compared with ESM. Moreover, postoperative reduction of the fiber count of finger pathway was associated with postoperative motor deficits involving the hand. The prediction model revealed an accuracy of 92% in avoiding postoperative deficits if the distance between the resection margin and the finger motor pathway seen on preoperative DWI tractography was 19.5 mm. This study provides evidence that the DWI-MAP combined with Kalman filter can effectively identify the locations of cortical motor areas even in patients whose motor areas are difficult to identify using ESM, and also can serve as a reliable predictor for motor deficits following epilepsy surgery.
authors.affiliation: Carman and Ann Adams Department of Pediatrics, Department of Neurology, School of Medicine, Wayne State University, Detroit, Michigan, USA; Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, Michigan, USA.
authors.forename: Jeong-Won
authors.initials: JW
authors.lastname: Jeong
authors.forename: Eishi
authors.initials: E
authors.lastname: Asano
authors.forename: Csaba
authors.initials: C
authors.lastname: Juhász
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D004525:Efferent Pathways / Q000473:pathology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008297:Male; D009044:Motor Cortex / Q000473:pathology*; D009069:Movement Disorders / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D011336:Probability; D012372:ROC Curve
keywords: corticospinal tract; diffusion weighted image tractography; epilepsy; presurgical planning; primary motor pathway