title: Colorectal cancer screening with fecal occult blood test: A 22-year cohort study.
abstract: The aim of the present study was to investigate the efficacy of colorectal cancer (CRC) screening with a three-tier fecal occult blood test (FOBT) in the Chinese population. The study was performed between 1987 and 2008 at the Beijing Military General Hospital, in a cohort of army service males and females aged >50 years. Between 1987 and 2005, a three-tier screening program, comprising guaiac-based FOBTs (gFOBTs), followed by immunochemical FOBTs for positive guaiac test samples and then colonoscopy for positive immunochemical test subjects, was performed annually. The cohort was followed up until 2008. The cohort included 5,104 subjects, of which, 3,863 subjects participated in screening (screening group) and 1,241 did not (non-screening group). The two groups did not differ in age, gender or other major risk factors for colon cancer. Overall, 36 CRCs occurred in the screening group and 21 in the non-screening group. Compared with the non-screening group, the relative risk for the incidence and mortality of CRC was 0.51 [95% confidence interval (CI), 0.30-0.87] and 0.36 (95% CI, 0.18-0.71), respectively, in the screening group. The general sensitivity of this three-tier FOBT was 80.6% (95% CI, 65.3-91.1). Thus, annual screening using the three-tier FOBT program may reduce the CRC incidence and mortality rate.
authors.affiliation: Department of Gastroenterology, Beijing Military General Hospital, Beijing 100700, P.R. China ; Third Military Medical University, Chongqing 400038, P.R. China ;
authors.forename: Peng
authors.initials: P
authors.lastname: Jin
authors.forename: Zi-Tao
authors.initials: ZT
authors.lastname: Wu
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Li
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Li
authors.forename: Ji-Heng
authors.initials: JH
authors.lastname: Wang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Lu
authors.forename: Xin-Juan
authors.initials: XJ
authors.lastname: Cui
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Jianyu
authors.initials: J
authors.lastname: Rao
authors.forename: Jian-Qiu
authors.initials: JQ
authors.lastname: Sheng
keywords: colorectal cancer; fecal occult blood test; screening