title: Elevation of serum cytokines preceding elevation of liver enzymes in a case of drug-induced liver injury.
abstract: A 50-year-old man who was being treated for both pneumonia and type 2 diabetes mellitus complained of abdominal distention on the 16th hospital day. Liver enzyme elevation without symptoms was detected on the 17th hospital day. Based on a Roussel Uclaf Causality Assessment Method score of 10 and a Japan Digestive Disease Week score of 9, we diagnosed the patient as having drug-induced liver injury (DILI). Simultaneous assays of the levels of cytokines revealed that the elevation of the levels of interleukin (IL)-1β, IL-10, IL-12, IL-13 and tumor necrosis factor-α preceded the elevation of the serum liver enzymes. This case suggests that some cytokines or related molecules are potentially useful as early-phase biomarkers for DILI.
authors.affiliation: Department of Gastroenterology, Kazuno Kosei Hospital, Kazuno, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kakisaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takikawa
keywords: Bio-Plex; interleukin-1β; monocytic chemotactic protein-1; tumor necrosis factor-α