title: [Field trial on the simultaneous vaccination against porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae].
abstract: OBJECTIVE
  The objective of the present study was to investigate whether a combined or concurrent application of two vaccines against Mycoplasma hyopneumoniae (M. hyo.) and porcine circovirus type 2 (PCV2) in suckling piglets can be as effective as the single use of both products.
  
  
  METHODS
  A total of 598 piglets were allocated to five groups. In the 1st and 3rd weeks of life the placebo Porcilis® Diluvac forte and the two vaccines Porcilis® M HYO ("M HYO") and Porcilis® PCV ("PCV") were administered according to the following scheme: group A: placebo/PCV; group B: M HYO/M HYO; group C: placebo/placebo; group D: M HYO/M HYO + PCV (combined single dose); group E: placebo/M HYO + PCV (different injection sites). Lung lesions due to M. hyo. infection were recorded at slaughter, and average daily weight gain, morbidity, mortality, serum PCV2 load and specific humoral immune responses were compared between the groups. Local and systemic side effects were recorded.
  
  
  RESULTS
  Sporadic impairment of the herd health status due to piglet diarrhoea (n = 111) from the 1st to 3rd weeks of life were not associated with M. hyo. or PCV2. A tendency towards a higher average daily weight gain was found in vaccinated pigs compared to the control group. Slight differences between groups in terms of lung lesions, morbidity and mortality were not significant. M. hyo. and PCV2 antibody-titers were significantly higher in vaccinated than in non-vaccinated pigs. One pig from both group A (PCV2) and group C (placebo) displayed local reactions at the vaccination site.
  
  
  CONCLUSIONS
  A positive effect on animal health can be achieved by vaccination against M. hyo. and PCV2 in herds with suboptimal health status. A simultaneous vaccination either by a combined or concurrent application has no negative effect on health status. Simultaneous vaccination yielded the same positive effect on average daily weight gain as single vaccinations. Therefore, a simultaneous vaccination against M. hyo. and PCV2, which reduces workload and is beneficial for animal welfare, can be recommended.
authors.affiliation: Mag. med. vet. Erwin Herbich, Abteilung für Biomedizinische Forschung, Medizinische Universität Wien, Allgemeines Krankenhaus Wien (AKH), Leitstelle 1Q, Währinger Gürtel 18-20/1Q, A-1090 Wien, E-Mail: erwin.herbich@meduniwien.ac.at.
authors.forename: E
authors.initials: E
authors.lastname: Herbich
authors.forename: B
authors.initials: B
authors.lastname: Heissenberger
authors.forename: A
authors.initials: A
authors.lastname: Ladinig
authors.forename: A
authors.initials: A
authors.lastname: Griessler
authors.forename: M
authors.initials: M
authors.lastname: Ritzmann
authors.forename: C
authors.initials: C
authors.lastname: Weissenbacher-Lang
authors.forename: I
authors.initials: I
authors.lastname: Hennig-Pauka
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D018173:Circoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D017925:Circovirus; D045705:Mycoplasma hyopneumoniae / Q000276:immunology* / Q000302:isolation & purification; D045729:Pneumonia of Swine, Mycoplasmal / Q000517:prevention & control*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines
keywords: Respiratory disease; combined vaccine; field trial; porcine respiratory disease complex (PRDC); postweaning multisystemic wasting syndrome (PMWS)