title: Dexamethasone effects on activation and proliferation of immune memory T cells.
abstract: Dose-dependent effects of dexamethasone on activation and proliferation of donor immune memory T cells (CD45RO(+)) were studied. Activation of memory T cells associated with IL-2 production and membrane expression of CD25 molecule was resistant to dexamethasone. Proliferative activity of memory T cells associated with membrane expression of CD71 molecule was highly sensitive to dexamethasone. Hence, glucocorticoid hormones can maintain the clonal balance in the lymphoid tissue without preventing realization of the immune memory mechanism.
authors.affiliation: Laboratory of Immunology and Cell Biotechnologies, Center of Medical Biotechnologies, Innovation Park, E. Kant Baltic Federal University, Kaliningrad, Russia. gutsol.alevtina@yandex.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Gutsol
authors.forename: N A
authors.initials: NA
authors.lastname: Sokhonevich
authors.forename: V I
authors.initials: VI
authors.lastname: Seledtsov
authors.forename: L S
authors.initials: LS
authors.lastname: Litvinova
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D011990:Receptors, Transferrin / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C068126:CD71 antigen; D005938:Glucocorticoids; C508017:IL2RA protein, human; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D011990:Receptors, Transferrin; D003907:Dexamethasone