title: Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality risk in critically ill children: a prospective study.
abstract: BACKGROUND
  We tested the hypothesis that higher mid-regional pro-adrenomedullin (MR-proADM), carboxy-terminal pro-endothelin-1 (CT-proET-1), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations would be associated with increased prediction of mortality risk scores.
  
  
  METHODS
  Prospective observational study set in two pediatric intensive care units (PICUs). Two-hundred-thirty-eight patients were included. MR-proADM, CT-proET-1, PCT and CRP levels were compared between children with PRISM III and PIM 2 > p75 (Group A; n = 33) and the rest (Group B; n = 205).
  
  
  RESULTS
  Median (range) MR-proADM levels were 1.39 nmol/L (0.52-12.67) in group A versus 0.54 (0.15-3.85) in group B (P < 0.001). CT-proET-1 levels were 172 pmol/L (27-500) versus 58 (4-447) (P < 0.001). PCT levels were 7.77 ng/mL (0.34-552.00) versus 0.28 (0.02-107.00) (P < 0.001). CRP levels were 6.23 mg/dL (0.08-28.25) versus 1.30 mg/dL (0.00-42.09) (P = 0.210). The area under the ROC curve (AUC) for the differentiation of group A and B was 0.87 (95% CI:0.81-0.821) for MR-proADM, 0.86 (95% CI:0.79-0.92) for CT-proET-1 and 0.84 (95% CI:0.74-0.94) for PCT. A MR-proADM > 0.79 nmol/L had 93% sensitivity and 76% specificity to differentiate groups, whereas a CT-proET-1 > 123 pmol/L had 77% sensitivity and 84% specificity, and a PCT concentration > 2.05 ng/mL had 80% sensitivity and specificity.
  
  
  CONCLUSIONS
  In critically ill children, high levels of MR-proADM, CT-proET-1 and PCT were associated with increased prediction of mortality risk scores. MR-proADM, CT-proET-1 and PCT concentrations higher than 0.80 nmol/L, 123 pmol/L and 2 ng/mL, respectively, could be used by clinicians to identify critically ill children at higher prediction of risk death scores.
authors.forename: Corsino
authors.initials: C
authors.lastname: Rey
authors.forename: Irene
authors.initials: I
authors.lastname: García-Hernández
authors.forename: Andrés
authors.initials: A
authors.lastname: Concha
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Camblor
authors.forename: Marta
authors.initials: M
authors.lastname: Botrán
authors.forename: Alberto
authors.initials: A
authors.lastname: Medina
authors.forename: Belén
authors.initials: B
authors.lastname: Prieto
authors.forename: Jesús
authors.initials: J
authors.lastname: López-Herce
mesh_terms: D053607:Adrenomedullin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness / Q000401:mortality*; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D012306:Risk; D012680:Sensitivity and Specificity; D013030:Spain / Q000453:epidemiology
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D019332:Endothelin-1; D011498:Protein Precursors; C088633:proadrenomedullin; C093240:proendothelin 1; D053607:Adrenomedullin; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide