title: Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy.
abstract: OBJECTIVE
  We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard.
  
  
  METHODS
  Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis.
  
  
  RESULTS
  The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m(2)) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m(2); P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m(2)) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25).
  
  
  CONCLUSIONS
  GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR.
  
  
  CONCLUSIONS
  • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.
authors.affiliation: Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea, kyi821209@naver.com.
authors.forename: Yong-il
authors.initials: YI
authors.lastname: Kim
authors.forename: Seunggyun
authors.initials: S
authors.lastname: Ha
authors.forename: Young
authors.initials: Y
authors.lastname: So
authors.forename: Won Woo
authors.initials: WW
authors.lastname: Lee
authors.forename: Seok-Soo
authors.initials: SS
authors.lastname: Byun
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate