title: On the significance of germline cytogenetic rearrangements at MYCN locus in neuroblastoma.
abstract: BACKGROUND
  MYCN oncogene amplification is the most important prognostic factor in neuroblastoma. 25% neuroblastoma tumors have somatic amplifications at this locus but little is known about its constitutional aberrations and their potential role in carcinogenesis. Here, we have performed an array-CGH and qPCR characterization of two patients with constitutional partial 2p trisomy including MYCN genomic region.
  
  
  RESULTS
  One of the patients had congenital neuroblastoma and showed presence of minute areas of gains and losses within the common fragile site FRA2C at 2p24 encompassing MYCN. The link between 2p24 germline rearrangements and neuroblastoma development was reassessed by reviewing similar cases in the literature.
  
  
  CONCLUSIONS
  It appears that constitutional rearrangements involving chromosome 2p24 may play role in NB development.
authors.affiliation: Department of Biology and Genetics, Medical University of Gdansk, Debinki 1str, 80211 Gdansk, Poland. b.lipska@gumed.edu.pl.
authors.forename: Beata S
authors.initials: BS
authors.lastname: Lipska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Koczkowska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wierzba
authors.forename: Anna
authors.initials: A
authors.lastname: Ploszynska
authors.forename: Mariola
authors.initials: M
authors.lastname: Iliszko
authors.forename: Ewa
authors.initials: E
authors.lastname: Izycka-Swieszewska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Adamkiewicz-Drozynska
authors.forename: Janusz
authors.initials: J
authors.lastname: Limon