title: Stereoselective synthesis of (3R)-3-alkyl-4,1-benzoxazepine-2,5-diones.
abstract: Novel 3-alkyl-4,1-benzoxazepine-2,5-diones were synthesized in good ee exploiting the chiral pool methodology, an economical way of asymmetric synthesis. Various anthranilic acids are coupled with different α-haloacids to afford N-acylated anthranilic acid intermediates which undergo cyclization to (3R)-3-alkyl-4,1-benzoxazepines-2,5-diones.
authors.affiliation: Ibn e Sina Block, Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
authors.forename: Bushra
authors.initials: B
authors.lastname: Nisar
authors.forename: Abdul Rauf
authors.initials: AR
authors.lastname: Raza
authors.forename: David Stc
authors.initials: DS
authors.lastname: Black
authors.forename: Naresh
authors.initials: N
authors.lastname: Kumar
authors.forename: Muhammad Nawaz
authors.initials: MN
authors.lastname: Tahir
mesh_terms: D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C453003:4,1-benzoxazepine; D010077:Oxazepines
keywords: 4,1-benzoxazepine-2,5-diones; N-acylation; anthranilic acid; coupling reaction; α-halo acids