title: Peritoneal dialysis versus hemodialysis in patients with delayed graft function.
abstract: Delayed graft function (DGF) in kidney transplantation affects adverse outcomes. It remains unclear whether the post-transplant dialysis modality alters perioperative or long-term graft outcomes. We performed a retrospective observational quality initiative at two Canadian renal transplant centers, in which DGF occurred in the recipient, necessitating one of peritoneal dialysis (PD) or hemodialysis (HD). There was no difference in baseline factors between patients with post-transplant PD (n = 14) or HD (n = 63). The use of PD was associated with an increased risk of wound infection/leakage (PD 5/14 vs. HD 6/63, p = 0.024), shorter length of hospitalization (13.7 vs. 18.7 d, p = 0.009) and time requiring dialysis post-operatively (6.5 vs 11.0 d, p = 0.043). There were no differences in readmission to hospital within 6 months (4/14 vs. 23/63, p = 0.759), graft loss (0/14 vs. 2/63, p = 1.000) or acute rejection episodes (1/14 vs. 4/63, p = 1.000) at one yr, and GFR did not differ between the PD or HD groups at 30 d (35.7 vs. 33.8 mL/min/m(2), p = 0.731), six months (46.9 vs. 45.5 mL/min/m(2), p = 0.835) or one yr (46.6 vs. 44.5 mL/min/m(2), p = 0.746). Further research is needed to determine which transplant patients are most appropriate to undergo PD catheter removal at the time of transplantation.
authors.affiliation: Kidney Clinical Research Unit, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Division of Nephro-logy, Department of Medicine, London Health Sciences Center, London, ON, Canada.
authors.forename: B K A
authors.initials: BK
authors.lastname: Thomson
authors.forename: M A J
authors.initials: MA
authors.lastname: Moser
authors.forename: C
authors.initials: C
authors.lastname: Marek
authors.forename: M
authors.initials: M
authors.lastname: Bloch
authors.forename: C
authors.initials: C
authors.lastname: Weernink
authors.forename: A
authors.initials: A
authors.lastname: Shoker
authors.forename: P P
authors.initials: PP
authors.lastname: Luke
mesh_terms: D051799:Delayed Graft Function / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D011379:Prognosis; D006435:Renal Dialysis; D012307:Risk Factors
keywords: delayed graft function; dialysis modality; perioperative complications; renal transplantation