title: Combination of a haploidentical SCT with an unrelated cord blood unit: a single-arm prospective study.
abstract: We conducted a single-arm prospective study in 50 patients who received the combination of an haploidentical stem cell graft and an unrelated umbilical cord blood unit for the treatment of hematological malignancies. The median time for neutrophil engraftment was 13 days (11-20 days), and for platelets was 15 days (11-180 days). All surviving patients attained complete haploidentical engraftment except three patients who presented a mixed engraftment with increasing cord blood and decreasing haplo mismatch chimerism during the first 4 months after transplantation. The cumulative incidence of grade II-IV acute GVHD was 20%±0.327% at day+100, and the incidence of chronic GVHD was 19.26%±1.0% at 1 year. The 1-year cumulative incidence of relapse was 19.78%±1%, and the TRM was 16.2%±0.54%. At 1 year, overall survival was 78.6%±7.6% and PFS 64.0%±11.0%. The BU/CY-based conditional regimen showed a significant superiority over TBI/CY on PFS (relative risk=5.012, 95% confidence interval, 1.146-21.927, P=0.032). In conclusion, the co-infusion of an unrelated cord blood unit may potentially improve the outcome of haploidentical allogeneic hematopoietic SCT.
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: R-X
authors.initials: RX
authors.lastname: Wang
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: A-N
authors.initials: AN
authors.lastname: Sun
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: H-Y
authors.initials: HY
authors.lastname: Qiu
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Jin
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: X-W
authors.initials: XW
authors.lastname: Tang
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Z-Z
authors.initials: ZZ
authors.lastname: Fu
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: G-S
authors.initials: GS
authors.lastname: He
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Miao
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.affiliation: 1] Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China [2] Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: D-P
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014184:Transplantation, Homologous; D061349:Unrelated Donors; D055815:Young Adult