title: Assessment of dynamic cerebral autoregulation in patients with basilar artery stenosis.
abstract: OBJECTIVE
  Previous studies have shown impaired cerebral autoregulation (CA) in carotid and middle cerebral artery (MCA) stenosis/occlusion. Little is known about CA in patients with basilar artery (BA) stenosis. We therefore investigated dynamic CA patterns in BA stenosis using transfer function analysis (TFA).
  
  
  METHODS
  We measured spontaneous oscillations of blood flow velocity (CBFV) in the right posterior cerebral artery (PCA), and left MCA and mean arterial pressure (ABP) continuously in 25 patients with BA stenosis (moderate n=16 with 50-69% occlusion and severe n=9 with ≥ 70% occlusion) and 22 healthy volunteers in supine position during 6 circles per minute deep breath. Analysis was based on the 'black-box' model of transfer function deriving phase and gain in both PCA and MCA.
  
  
  RESULTS
  Though changes of phase shift and gain between the patients and healthy controls were observed in MCA, the differences are however not significant. Phase shift in PCA was significantly decreased in severe stenosis when comparing with healthy controls and moderate stenosis (4.2 ± 34.2° VS 41.1 ± 40.4°, 4.2 ± 34.2° VS 34.2 ± 27.2°, both p<0.05), whilst the gain in PCA is increased for moderate BA stenosis and decreased for severe BA stenosis. Furthermore, we found that phase shift were almost abolished in patients with ischemic stroke who developed unfavorable clinical outcome (mRs>2) on the 90 days after stroke onset.
  
  
  CONCLUSIONS
  Dynamic CA in PCA reduces in patients with severe BA stenosis and those with ischemic stroke who present poor outcome in 90 days after stroke onset. Phase shift might be a sensitive index prompting impaired CA in posterior circulation.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, affiliated to Capital Medical University, Beijing, China.
authors.forename: Xiping
authors.initials: X
authors.lastname: Gong
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Pei
authors.initials: P
authors.lastname: Dong
authors.forename: Pandeng
authors.initials: P
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D005260:Female; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D014463:Ultrasonography; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology