title: Mitochondrial protein quality control in health and disease.
abstract: Progressive mitochondrial dysfunction is linked with the onset of many age-related pathologies and neurological disorders. Mitochondrial damage can come in many forms and be induced by a variety of cellular insults. To preserve organelle function during biogenesis or times of stress, multiple surveillance systems work to ensure the persistence of a functional mitochondrial network. This review provides an overview of these processes, which collectively contribute to the maintenance of a healthy mitochondrial population, which is critical for cell physiology and survival.
authors.affiliation: Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia; ARC Centre of Excellence for Coherent X-ray Science, Melbourne, VIC, Australia.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Baker
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Palmer
authors.forename: Diana
authors.initials: D
authors.lastname: Stojanovski
mesh_terms: D016923:Cell Death; D006706:Homeostasis; D006801:Humans; D024101:Mitochondrial Proteins / Q000378:metabolism*; D063269:Mitochondrial Turnover; D063306:Mitophagy; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins
keywords: apoptosis; mitochondria; mitochondrial morphology; neurodegenerative disease; protease; protein quality control