title: Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients.
abstract: Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy.
authors.affiliation: Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland, VTT, Espoo, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Hilvo
authors.forename: Stephan
authors.initials: S
authors.lastname: Gade
authors.forename: Tuulia
authors.initials: T
authors.lastname: Hyötyläinen
authors.forename: Valentina
authors.initials: V
authors.lastname: Nekljudova
authors.forename: Tuulikki
authors.initials: T
authors.lastname: Seppänen-Laakso
authors.forename: Marko
authors.initials: M
authors.lastname: Sysi-Aho
authors.forename: Michael
authors.initials: M
authors.lastname: Untch
authors.forename: Jens
authors.initials: J
authors.lastname: Huober
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
authors.forename: Carsten
authors.initials: C
authors.lastname: Denkert
authors.forename: Matej
authors.initials: M
authors.lastname: Orešič
authors.forename: Sibylle
authors.initials: S
authors.lastname: Loibl
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism; D017326:Clinical Trials, Phase III as Topic; D018572:Disease-Free Survival; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D015337:Multicenter Studies as Topic; D020360:Neoadjuvant Therapy / Q000379:methods; D019301:Oleic Acid / Q000097:blood*; D016032:Randomized Controlled Trials as Topic; D011960:Receptors, Estrogen / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*
chemical_list: D005229:Fatty Acids, Monounsaturated; D011960:Receptors, Estrogen; D014280:Triglycerides; D019301:Oleic Acid
keywords: breast cancer; lipidomics; oleic acid; pathologic complete response rate; stearoyl-CoA desaturase (SCD)