title: Clinical and enterovirus findings associated with acute flaccid paralysis in the Republic of Korea during the recent decade.
abstract: Acute flaccid paralysis (AFP) is described as sudden onset of flaccid paralysis in one or more limbs in children caused by polioviruses (PVs). PV eradication is achieved through intensive immunization and AFP attentive surveillance, according to the World Health Organization. Since 1998, the Korea Centers for Disease Control and Prevention has conducted surveillance system. This is an overview of surveillance in the Republic of Korea during the 10-year period from 2002 to 2011. The surveillance system for wild PV eradication was conducted through reporting and laboratory testing. Cell culture isolates were identified by neutralization tests using standard polyclonal antisera typing. The molecular methods were used for further characterization to improve specificity. For genotyping, semi-nested RT-PCR was used to amplify part of the viral protein 1 gene. Patients below 5 years of age accounted for the largest proportion of cases, and a positive association between age and incidence was found. In the total 285 cases, Guillain-Barré syndrome was the major leading causes of AFP. Non-polio enterovirus was detected in some AFP patients. EV71 was detected in 21 cases and Coxsackievirus (C) A2, CA6, CA9, CB2, CB3, CB4, CB5, and Echovirus (E) 25, E30, Sabin strain polio 2, polio 1 and 3 were also detected in some patients. The present study represents a comprehensive 10-year country-based survey of AFP in the Republic of Korea. This surveillance could provide better understanding of the epidemiologic pattern, and clinical manifestations associated with specific genotypes of AFP in the Republic of Korea.
authors.affiliation: Division of Vaccine Research, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, South Korea; Department of Biology, Graduate School, Kyung Hee University, Seoul, South Korea.
authors.forename: HyeJin
authors.initials: H
authors.lastname: Kim
authors.forename: Byounghak
authors.initials: B
authors.lastname: Kang
authors.forename: Seoyeon
authors.initials: S
authors.lastname: Hwang
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Doo-Sung
authors.initials: DS
authors.lastname: Cheon
authors.forename: Kisang
authors.initials: K
authors.lastname: Kim
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Jeong
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Hyeon
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000453:epidemiology*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010243:Paralysis / Q000453:epidemiology* / Q000821:virology; D056910:Republic of Korea / Q000453:epidemiology
keywords: acute flaccid paralysis; enterovirus; poliovirus