title: Associations of serum C-peptide level with body fat distribution and ever stroke in nondiabetic subjects.
abstract: BACKGROUND
  Although elevated serum C-peptide level as an indicator of insulin resistance increases the obesity-associated risk of cardiovascular disease among diabetic patients, evidence indicating that serum C-peptide level is associated with stroke in nondiabetic subjects is limited. The aim of this study is to evaluate the association between serum C-peptide level and ever stroke in nondiabetic subjects and investigated the associations of serum C-peptide level with body fat distribution and stroke events among nondiabetic subjects.
  
  
  METHODS
  This study was a population-based cross-sectional study that included 7030 participants aged 12-85 years. Body fat distribution was determined by dual-energy X-ray absorptiometry. Serum C-peptide level was measured using the radioimmunoassay method. The association between serum C-peptide level and body fat distribution was evaluated by multiple linear regression models. Logistic regression analysis was performed to calculate the odds ratio (OR) of serum C-peptide level being associated with ever stroke.
  
  
  RESULTS
  A total of 103 nondiabetic subjects reported having a stroke. Logistic regression analysis revealed a high-serum C-peptide level significantly associated with ever stroke among nondiabetic subjects (OR: 3.71, 95% confidence interval: 1.78-7.75). Meanwhile, in multiple linear regression analysis, serum C-peptide level was positively associated with total and regional fat distribution among nondiabetic subjects.
  
  
  CONCLUSIONS
  The serum C-peptide level is strongly associated with the ever stroke in nondiabetic subjects and significantly associated with total and regional body fat distribution.
authors.affiliation: Department of Social Medicine, School of Public Health, Zhejiang University, Zhejiang, China. Electronic address: ying_li@zju.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Social Medicine, School of Public Health, Zhejiang University, Zhejiang, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Clinical Medicine, School of Medicine, Zhejiang University, Zhejiang, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hygiene and Public Health II, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Sato
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016017:Odds Ratio; D011863:Radioimmunoassay; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014481:United States; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide
keywords: Serum C-peptide; body fat distribution; fasting plasma glucose; serum insulin; stroke