title: Health-related quality of life in Turner syndrome and the influence of key features.
abstract: OBJECTIVE
  To evaluate health-related quality of life (HRQoL) in a group of girls with Turner syndrome (TS) and determine its relation to key features of the condition.
  
  
  METHODS
  HRQoL was assessed with the short-form health survey (SF-36).
  
  
  RESULTS
  Of the 35 girls, 32 [mean (SD) age: 16.7 (2.61) years], of whom 28 (87.6%) received growth hormone therapy, agreed to participitate. Compared with the general population, girls with TS have lower scores in the physical functioning domain of HRQoL. However, they have similar HRQoL as their peers in other dimensions. There was a negative and significant association between the postmenarchal status and the social functioning domain of HRQoL. Age at growth hormone treatment initiation has a negative impact on the general health domain. Age at growth hormone initiation, bone mineral apparent density (BMAD) and the prevalence of skeletal anomalies negatively influence the vitality domain. HRQoL scores in the physical function domain were negatively associated with BMAD and positively associated with height.
  
  
  CONCLUSIONS
  Compared with the general population, Irish girls with TS have similar HRQoL in most of domains as their peers. Postmenarchal status, height, age at growth hormone initiation, BMAD and skeletal anomalies showed significant association with at least one domain of HRQOL.
authors.forename: Montasser
authors.initials: M
authors.lastname: Nadeem
authors.forename: Edna F
authors.initials: EF
authors.lastname: Roche
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007494:Ireland; D007621:Karyotyping; D011788:Quality of Life; D014424:Turner Syndrome / Q000235:genetics / Q000503:physiopathology*