title: Equine pastern vasculitis: a clinical and histopathological study.
abstract: Equine pastern vasculitis is clinically challenging and the underlying aetiopathogenesis is unclear. The aims of this retrospective study were to establish histopathological criteria for pastern vasculitis, to look for an underlying cause, to investigate whether the histopathological lesions are associated with a distinct clinical picture, to assess if and how the clinical picture varies, and to determine the treatment response. Skin biopsies and clinical data from 20 horses with a diagnosis of vasculitis of the distal extremities were investigated and histology was compared to biopsies from healthy horses. It was concluded that intramural inflammatory cells, leukocytoclasia with nuclear dust, thickening and oedema of the vessel walls, and microhaemorrhages are highly specific histological findings in equine pastern vasculitis. Based on the feedback from the clinicians, the lesions were mostly seen on the lateral and medial aspects of un-pigmented legs. Lesions in white skin were characterised by exudation and crusts, whereas those in pigmented skin were alopecic and characterised by scaling. The response to treatment was poor and the prognosis guarded. No association was found between any of the histopathological findings and a distinct clinical picture. An underlying cause of equine pastern vasculitis could not be identified. Considering the large number of confounding factors, the causative agents are difficult to identify, but may involve drugs or a hypersensitivity reactions to yet unknown antigens.
authors.affiliation: Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Psalla
authors.forename: Silvia
authors.initials: S
authors.lastname: Rüfenacht
authors.forename: Michael H
authors.initials: MH
authors.lastname: Stoffel
authors.forename: Koen
authors.initials: K
authors.lastname: Chiers
authors.forename: Véronique
authors.initials: V
authors.lastname: Gaschen
authors.forename: Marcus G
authors.initials: MG
authors.lastname: Doherr
authors.forename: Vincent
authors.initials: V
authors.lastname: Gerber
authors.forename: Monika M
authors.initials: MM
authors.lastname: Welle
mesh_terms: D000818:Animals; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D006736:Horses; D010858:Pigmentation; D012189:Retrospective Studies; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*
keywords: Histopathology; Horse; Pastern dermatitis; Treatment; Vasculitis