title: Whole genome comparison of donor and cloned dogs.
abstract: Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences.
authors.affiliation: 1] Personal Genomics Institute, Genome Research Foundation, Suwon 443-270, Korea [2].
authors.forename: Hak-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Yun Sung
authors.initials: YS
authors.lastname: Cho
authors.forename: Hyunmin
authors.initials: H
authors.lastname: Kim
authors.forename: Sungwoong
authors.initials: S
authors.lastname: Jho
authors.forename: Bongjun
authors.initials: B
authors.lastname: Son
authors.forename: Joung Yoon
authors.initials: JY
authors.lastname: Choi
authors.forename: Sangsoo
authors.initials: S
authors.lastname: Kim
authors.forename: Byeong Chun
authors.initials: BC
authors.lastname: Lee
authors.forename: Jong
authors.initials: J
authors.lastname: Bhak
authors.forename: Goo
authors.initials: G
authors.lastname: Jang
mesh_terms: D000818:Animals; D019976:Cloning, Organism / Q000662:veterinary*; D004285:Dogs; D016678:Genome; D042822:Genomic Instability; D008297:Male; D009154:Mutation; D017422:Sequence Analysis, DNA; D059505:Telomere Homeostasis; D014430:Twins, Monozygotic