title: Association between glutathione S-transferase T1 null  genotype and glioma susceptibility: a meta-analysis.
abstract: The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However, these studies report inconsistent results. In order to get this precise result, a meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95% confidence intervals (95 % CI). Eleven case-control research studies with a total of 2,416 glioma cases and 4,850 controls were included into this meta-analysis. The combined results based on all studies showed that there was no significant association between the GSTT1 null allele and glioma risk (OR = 1.188, 95% CI = 0.929–1.520, P(heterogeneity) = 0.003, P = 0.170). In the subgroup analysis, the same results were found in our work. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null genotype was not associated with the increased risk of glioma.
authors.forename: Benping
authors.initials: B
authors.lastname: Zhang
authors.forename: Jianjiao
authors.initials: J
authors.lastname: Wang
authors.forename: Hongshuang
authors.initials: H
authors.lastname: Niu
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.forename: Fenggang
authors.initials: F
authors.lastname: Zhou
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hao
authors.forename: Yongri
authors.initials: Y
authors.lastname: Zheng
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Li
authors.forename: Weizhi
authors.initials: W
authors.lastname: Wang
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase