title: Vascular endothelial growth factor gene polymorphisms and vitreous proteome changes in diabetic retinopathy.
abstract: Ischemic retinal diseases, particularly diabetic retinopathy, continue to significantly impact vision and remain a leading cause of vision loss in working-aged adults. Identifying specific genetic risk factors for ischemic-driven pathways that increase susceptibility to developing diabetic retinopathy is a priority to allow development of accurate risk assessment algorithms, employ earlier intervention, and design novel treatment strategies to reduce the associated visual complications. Single nucleotide polymorphisms (SNPs) in the VEGF gene have been shown to influence the expression of the VEGF protein. Several studies suggest that SNPs in the VEGF gene mediate genetic predisposition to diabetic retinopathy. In addition, alterations in the vitreous proteome, including carbonic anhydrase mediated vascular permeability, have been found to be associated with sight-threatening proliferative diabetic retinopathy and macular edema. Inhibition of these factors could provide new therapeutic opportunities for the treatment of diabetic retinopathy.
authors.affiliation: Beetham Eye Institute, Joslin Diabetes Center , Boston, Massachusetts , USA and.
authors.forename: Kelli H
authors.initials: KH
authors.lastname: Dyer
authors.forename: Paolo S
authors.initials: PS
authors.lastname: Silva
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Sun
mesh_terms: D024401:Carbonic Anhydrase I / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D020543:Proteome / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D005136:Eye Proteins; D020543:Proteome; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D024401:Carbonic Anhydrase I