title: Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood.
abstract: The aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against EpsteinBarr virus early antigen (EBV-EA) activation induced with 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and against melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 melanoma cells, as well as potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity. Two phenolic acid derivatives, bergenin (1) and gallic acid (2), were isolated from the ethyl acetate (AcOEt)-soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV-EA activation and against skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis-inhibitory activities in α-MSH-stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical-scavenging activity.
authors.affiliation: College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nishimoto
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Suzuki
authors.forename: Ken
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Worapong
authors.initials: W
authors.lastname: Kitdamrongtham
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akazawa
authors.forename: Aranya
authors.initials: A
authors.lastname: Manosroi
authors.forename: Jiradej
authors.initials: J
authors.lastname: Manosroi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akihisa
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000956:Antigens, Viral / Q000737:chemistry / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D007887:Fabaceae / Q000737:chemistry* / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D005707:Gallic Acid / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018922:HL-60 Cells; D006801:Humans; D008543:Melanins / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D001578:Benzopyrans; C033305:Epstein-Barr virus early antigen; D016166:Free Radical Scavengers; D008543:Melanins; D010936:Plant Extracts; D005707:Gallic Acid; C006741:bergenin
keywords: Anti-tumor-promoting activity; Antioxidant activity; Bergenin; Melanogenesis inhibition; Peltophorum pterocarpum; Radical-scavenging activity