title: Astrocyte elevated gene-1 overexpression in histologically favorable Wilms tumor is related to poor prognosis.
abstract: OBJECTIVE
  Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in various types of human cancers. However, the status of AEG-1 expression and its significance in Wilms tumor are still unclear. In this study, we investigated the expression of AEG-1 and evaluated its clinical and prognostic significance in favorable-histology Wilms tumor (FHWT).
  
  
  METHODS
  Immunohistochemistry was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 38 FHWT patients. All patients underwent radical nephrectomy from January 2003 to June 2008 with subsequent therapy according to National Wilms Tumor Study Group protocols. Statistical analyses were performed to evaluate the association between AEG-1 expression and clinical parameters.
  
  
  RESULTS
  We found high AEG-1 expression in 17 of 38 (44.7%) patients. AEG-1 expression was significantly correlated with clinical stage (p = 0.019) and status of recurrence (p = 0.023). Importantly, patients with high AEG-1 expression had a shorter disease-free survival and overall survival compared with those with low AEG-1 expression (p = 0.011 and p = 0.013).
  
  
  CONCLUSIONS
  AEG-1 expression is associated with FHWT outcome in this study, and AEG-1 may represent a novel and valuable predictor for prognostic evaluation of FHWT patients.
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, PR China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong Province, PR China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong Province, PR China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Shandong Medical Imaging Research Institute, Medical School of Shandong University, Jinan, Shandong Province, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
authors.affiliation: Department of Pediatric Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, Shandong Province, PR China. Electronic address: wrd2190@126.com.
authors.forename: Rong-De
authors.initials: RD
authors.lastname: Wu
mesh_terms: D001707:Biopsy, Needle; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008565:Membrane Proteins; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016601:RNA-Binding Proteins; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: AEG-1; Immunohistochemistry; Prognosis; Survival; Wilms tumor