title: The status of serum vitamin D in patients with active Behcet's disease compared with controls.
abstract: OBJECTIVE
  The aim of this study was to characterize the status of vitamin D in patients with active and recently diagnosed Behcet's disease (BD) and the relationship between vitamin D levels and BD activity.
  
  
  METHODS
  In this cross sectional study 48 patients with BD and 47 age- and sex-matched healthy controls were included. BD was diagnosed by the International Criteria for BD. Behcet's patients were new cases who were not on any treatment. BD activity was measured by the Iranian Behcet's Disease Dynamic Activity Measure (IBDDAM) and Behcet's Disease Current Activity Form (BDCAF). 25(OH)D measured by enzyme-linked immunosorbent assay method as an indicator of vitamin D status.
  
  
  RESULTS
  The mean 25-hydroxyvitamin D (25(OH)D level in the BD group was lower than the control group. Insufficiency and deficiency of 25(OH)D in the BD group was more common than the control group. No correlation was observed between the total IBDDAM, ophthalmic IBDDAM, and BDCAF with 25(OH)D levels. No correlation was found between the major symptoms of BD and 25(OH)D value.
  
  
  CONCLUSIONS
  Our study suggests that deficiency of 25(OH)D may be a trigger factor for BD.
authors.affiliation: Tabriz Rheumatology Research Team, Connective Tissue Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Khabbazi
authors.forename: Nadereh
authors.initials: N
authors.lastname: Rashtchizadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbanihaghjo
authors.forename: Mehrzad
authors.initials: M
authors.lastname: Hajialiloo
authors.forename: Mortasa
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Ramin
authors.initials: R
authors.lastname: Taei
authors.forename: Sousan
authors.initials: S
authors.lastname: Kolahi
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000175:diagnosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25(OH)D; Behcet's disease; pathogenesis; vitamin D