title: The neuro-immune axis: prospect for novel treatments for mental disorders.
abstract: Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach.
authors.affiliation: Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
authors.forename: Aletta D
authors.initials: AD
authors.lastname: Kraneveld
authors.forename: Caroline G M
authors.initials: CG
authors.lastname: de Theije
authors.forename: Floor
authors.initials: F
authors.lastname: van Heesch
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Borre
authors.forename: Sander
authors.initials: S
authors.lastname: de Kivit
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
authors.forename: Mechiel
authors.initials: M
authors.lastname: Korte
authors.forename: Johan
authors.initials: J
authors.lastname: Garssen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001321:Autistic Disorder / Q000188:drug therapy / Q000276:immunology; D001921:Brain / Q000503:physiopathology; D002490:Central Nervous System / Q000187:drug effects; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000276:immunology; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology*
chemical_list: D000893:Anti-Inflammatory Agents