title: Concentration of plasma neutrophil gelatinase-associated lipocalin in patients with chronic kidney disease.
abstract: BACKGROUND
  The inclining incidence of chronic kidney disease which has led to high mortality and immense medical burden over the past decades has become a distressing concern in epidemiology. Unfortunately, the number of biomarkers that allow the monitoring of chronic kidney disease (CKD) is limited. Neutrophil gelatinase-associated lipocalin (NGAL) is an emerging biomarker which has been shown to be able to diagnose kidney injuries.
  
  
  METHODS
  Eighty-one nondiabetic patients with chronic kidney disease, stage 2 to 5, were recruited for this study, and 17 healthy volunteers with eGFR greater than 90 mL/minute/1.73m(2) were selected as the control group.
  
  
  RESULTS
  Our study demonstrated that the pNGAL level is elevated during CKD, and the pNGL level has a strong correlation with the concentration of sCr and eGFR.
  
  
  CONCLUSIONS
  Plasma neutrophil gelatinase-associated lipocalin is a potent tool in the diagnosis of chronic kidney diseases and is shown to have high correlation with serum creatinine and estimated glomerular filtration rate.
authors.affiliation: Department of Clinical Laboratory, Pingtung Christian Hospital, Taiwan.
authors.forename: Kai-Di
authors.initials: KD
authors.lastname: Wu
authors.forename: Liang-Lan
authors.initials: LL
authors.lastname: Hsing
authors.forename: Ya-Fang
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000209:Acute-Phase Proteins; D000368:Aged; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000097:blood*
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins