title: Disseminated Rhizopus microsporus infection following allogeneic hematopoietic stem cell transplantation in a child with severe aplastic anemia.
abstract: Disseminated Rhizopus microsporus infections are uncommon in children and are resistant to echinocandin and azole antifungal agents. We describe a child with severe aplastic anemia who developed disseminated R. microsporus infection following allogeneic hematopoietic stem cell transplantation. R. microsporus was identified microscopically in the hepatic drain culture and was confirmed on the basis of 18S rRNA and 28S rRNA sequence analyses. The patient was treated successfully with hepatic drainage and amphotericin B deoxycholate.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Ye
authors.forename: D
authors.initials: D
authors.lastname: Yu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Shao
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007674:Kidney Diseases / Q000382:microbiology; D008107:Liver Diseases / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000382:microbiology; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D012233:Rhizopus
keywords: Rhizopus microsporus; allogeneic hematopoietic stem cell transplantation; antifungal therapy; pediatric; severe aplastic anemia