title: Fasting plasma adropin concentrations correlate with fat consumption in human females.
abstract: OBJECTIVE
  This study investigated whether plasma adropin concentrations are influenced by sleep restriction and correlate with dietary preferences.
  
  
  METHODS
  Plasma adropin concentrations were measured by ELISA using samples from a study that investigated feeding behavior in sleep deprived lean (body mass index 22-26 kg/m(2) ) men and women aged 30-45 y. Sleep (habitual or restricted to 4h/night) and diet were controlled during a 4-day inpatient period. On day 5, food was self-selected (FS). Adropin was measured on day 4 in samples collected throughout the day, and then after an overnight fast at 0730 on days 5 (Pre-FS) and 6 (Post-FS).
  
  
  RESULTS
  Plasma adropin concentrations were not affected by sleep restriction. However, circulating adropin concentrations correlated with food selection preferences in women, irrespective of sleep status. Pre-FS adropin correlated positively with fat intake (total fat, r = 0.867, P < 0.05; saturated fat, r = 0.959, P < 0.01) and negatively with carbohydrate intake (r = -0.894, P < 0.05) as a percent total energy. Post-FS adropin correlated with total (r = 0.797, P < 0.05) and saturated fat intake (r = 0.945, P < 0.01), and negative with total carbohydrate intake (r = -0.929, P < 0.01). Pre-FS adropin also correlated with fat intake in kcal adjusted for body size (total fat, r = 0.852, P < 0.05; saturated fat, r = 0.927, P < 0.01).
  
  
  CONCLUSIONS
  Plasma adropin concentrations correlate with fat consumption in women.
authors.affiliation: New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital and College of Physicians and Surgeons, Columbia University, New York, 10025, USA.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: St-Onge
authors.forename: Ari
authors.initials: A
authors.lastname: Shechter
authors.forename: Julie
authors.initials: J
authors.lastname: Shlisky
authors.forename: Charmaine S
authors.initials: CS
authors.lastname: Tam
authors.forename: Su
authors.initials: S
authors.lastname: Gao
authors.forename: Eric
authors.initials: E
authors.lastname: Ravussin
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Butler
mesh_terms: D000328:Adult; D001798:Blood Proteins; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004435:Eating / Q000502:physiology; D005215:Fasting / Q000097:blood*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D006801:Humans; D007297:Inpatients; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D012737:Sex Factors; D012892:Sleep Deprivation / Q000503:physiopathology
chemical_list: D001798:Blood Proteins; D004040:Dietary Carbohydrates; D004041:Dietary Fats; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides