title: Efficient parallel Levenberg-Marquardt model fitting towards real-time automated parametric imaging microscopy.
abstract: We present a fast, accurate and robust parallel Levenberg-Marquardt minimization optimizer, GPU-LMFit, which is implemented on graphics processing unit for high performance scalable parallel model fitting processing. GPU-LMFit can provide a dramatic speed-up in massive model fitting analyses to enable real-time automated pixel-wise parametric imaging microscopy. We demonstrate the performance of GPU-LMFit for the applications in superresolution localization microscopy and fluorescence lifetime imaging microscopy.
authors.affiliation: College of Information and Electrical Engineering, China Agricultural University, Beijing, China ; College of Economics & Management, China Agricultural University, Beijing, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhu
authors.forename: Dianwen
authors.initials: D
authors.lastname: Zhang
mesh_terms: D001331:Automation; D003196:Computer Graphics; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D008856:Microscopy, Fluorescence; D008962:Models, Theoretical; D012984:Software; D013997:Time Factors