title: BAG3 is upregulated by c-Jun and stabilizes JunD.
abstract: BAG3 plays a regulatory role in a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, epithelial-mesenchymal transition (EMT), autophagy activation, and virus infection. The AP-1 transcription factors are implicated in a variety of important biological processes including cell differentiation, proliferation, apoptosis and oncogenesis. Recently, it has been reported that AP-1 protein c-Jun inhibits autophagy and enhances apoptotic cell death mediated by starvation. However, the molecular mechanisms remain unclear. For the first time, the current study demonstrated that serum starvation downregulated BAG3 at the transcriptional level via c-Jun. In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by BAG3.
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China; Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China; Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, the 1st Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Si
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
authors.forename: De-Hui
authors.initials: DH
authors.lastname: Kong
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Zong
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
authors.forename: Bao-Qin
authors.initials: BQ
authors.lastname: Liu
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China.
authors.forename: Yifu
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Department of Endocrinology and Metabolism, the 1st Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Zhen-Xian
authors.initials: ZX
authors.lastname: Du
authors.affiliation: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang 110001, China; Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China; Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang 110001, China. Electronic address: wanghq_doctor@hotmail.com.
authors.forename: Hua-Qin
authors.initials: HQ
authors.lastname: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D051017:Apoptosis Regulatory Proteins; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D006801:Humans; D055550:Protein Stability / Q000187:drug effects; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D020871:RNA Stability / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C414431:BAG3 protein, human; D016895:Culture Media, Serum-Free; C559371:JunD protein, human; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger
keywords: BAG3; Growth inhibition; JunD; c-Jun