title: ADAM33 polymorphisms are associated with asthma and a distinctive palm dermatoglyphic pattern.
abstract: A close correlation between asthma and palm dermatoglyphic patterns has been observed in previous studies, but the underlying genetic mechanisms have not been investigated. A disintegrin and metalloprotein‑33 (ADAM33) polymorphisms are important in the development of asthma and other atopic diseases. To investigate the underlying mechanisms of the association between asthma and distinctive palm dermatoglyphic patterns, thirteen ADAM33 single‑nucleotide polymorphisms (SNPs) were analyzed for the association between asthma and palm dermatoglyphic patterns in a population of 400 asthmatic patients and 200 healthy controls. Based on the results, five SNPs, rs44707 (codominant model, P=0.031; log‑additive model, P=0.0084), rs2787094 (overdominant model, P=0.049), rs678881 (codominant model, P=0.028; overdominant model, P=0.0083), rs677044 (codominant model, P=0.013; log‑additive model, P=0.0033) and rs512625 (dominant model, P=0.033), were associated with asthma in this population. Two SNPs, rs44707 (dominant model, P=0.042) and rs2787094 (codominant model, P=0.014; recessive model, P=0.0038), were observed in the asthma patients with the distinctive palm pattern. As rs44707 and rs2787094 are associated with asthma and a distinctive palm pattern, the data suggest that ADAM33 polymorphisms are correlated with asthma and may be the underlying genetic basis of the association between asthma and palm dermatoglyphic patterns.
authors.affiliation: Department of Respiratory Medicine, Qingdao Haici Hospital, Qingdao, Shandong 266033, P.R. China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Xue
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Zhao-Shan
authors.initials: ZS
authors.lastname: Zhou
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000368:Aged; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D003878:Dermatoglyphics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008663:Metacarpus / Q000033:anatomy & histology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human