title: Potential environmental implications of emerging organic contaminants in Taihu Lake, China: comparison of two ecotoxicological assessment approaches.
abstract: In this study, the hazard quotient (HQ) and a novel enhanced integrated biomarker response (EIBR) were applied to indirectly/directly estimate the ecotoxicological risk of emerging organic contaminants in Taihu Lake. Nine out of sixteen target compounds were detected in most sampling points at comparable concentrations (1.58-206.95 ng/L). Simultaneously, changes in multi-biomarkers were measured in caged fish for 28 days. The 0HQ results preliminarily indicated that most water areas were at significant risk for adverse effects to aquatic organisms (HQ>10). The prioritisation was then ranked and 17α-ethinylestradiol, diethylstilbestrol and 17β-estradiol were regarded as the greatest hazards. The EIBR, covering multi-biomarkers and their weighting, was applied to field study, and Zhushan Bay was suggested as the most stressful place, followed by Meiliang Bay. The HQ showed significant positive linear correlation with the EIBR (r=0.848, P<0.001), suggesting mutual consistency between the two approaches based on laboratory and field study in ecotoxicological risk assessment.
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China; College of Biological and Chemical Engineering, Anhui Polytechnic University, Wuhu 241000, China.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China. Electronic address: ghlu@hhu.edu.cn.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Lu
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
authors.forename: Jianchao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
authors.forename: Zhengxin
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
authors.forename: Donghai
authors.initials: D
authors.lastname: Wu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002681:China; D054750:Ecotoxicology; D004784:Environmental Monitoring / Q000379:methods; D004997:Ethinyl Estradiol / Q000032:analysis / Q000633:toxicity; D060106:Lakes / Q000737:chemistry*; D018675:Toxicity Tests / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical; D004997:Ethinyl Estradiol
keywords: Emerging organic contaminant; Enhanced integrated biomarker response; Hazard quotient; Taihu Lake