title: Antiphospholipid antibodies: neuropsychiatric presentations.
abstract: Antiphospholipid antibodies (aPL) are associated with a wide range of neurological, psychological, and psychiatric manifestations. In addition to clearly delineated purely thrombotic manifestations, which define the neurological contribution to the antiphospholipid syndrome, the strength of the other described associations is highly variable, and the underlying pathophysiological mechanisms are not fully understood. Some indications seem to support a psychiatric impact of aPL. The magnitude of the association and cellular and molecular mechanisms involved need to be further elucidated.
authors.affiliation: Department of Haematology, University Hospital, Nîmes and University of Montpellier, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Gris
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brenner
mesh_terms: D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000503:physiopathology; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D013927:Thrombosis / Q000276:immunology* / Q000503:physiopathology
chemical_list: D017152:Antibodies, Antiphospholipid