title: Association between CDH13 variants and cardiometabolic and vascular phenotypes in a Korean population.
abstract: OBJECTIVE
  Although some CDH13 single nucleotide polymorphisms (SNPs) have been shown to be determinants of blood adiponectin levels, the clinical implications of CDH13 variants are not yet completely understood. The purpose of this study was to evaluate the effects of SNPs of CDH13 on metabolic and vascular phenotypes.
  
  
  METHODS
  We included 238 hypertensive subjects and 260 age- and sex-matched controls. Seven tagging-SNPs were identified in the CDH13 gene by whole gene sequencing. The association between these SNP variants and the risk of hypertension, metabolic traits, and carotid intima-media thickness (IMT) was examined.
  
  
  RESULTS
  Minor allele carriers of rs12444338 had a lower risk of hypertension, but the association turned out just marginal after adjusting confoudners. Blood glucose levels were higher in the minor allele carriers of c.1407C>T (p=0.01), whereas low-density lipoprotein-cholesterol levels were greater in those of rs6565105 (p=0.02). The minor allele of rs1048612 was associated with a higher body mass index (p=0.01). In addition, the mean carotid IMT was significantly associated with rs12444338 (p=0.02) and rs1048612 (p=0.02).
  
  
  CONCLUSIONS
  These results provide evidence that CDH13 variants are associated with metabolic traits and carotid atherosclerosis in Koreans. This study shows the multifaceted effects of CDH13 variants on cardiometabolic risk.
authors.affiliation: Cardiology Division, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. shl1106@yuhs.ac.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Dong-Jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Kang
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Sang-Hak
authors.initials: SH
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000235:genetics; D044466:Asian People; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D015820:Cadherins / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D015820:Cadherins; C099972:H-cadherin; D002784:Cholesterol
keywords: CDH13 protein; atherosclerosis; cholesterol; glucose; human; hypertension