title: Norlathyrane diterpenes from the root of Euphorbia kansuensis.
abstract: Phytochemical investigation of the EtOH extract obtained from the root of the Euphorbia kansuensis Proch. grown in China resulted in the isolation of two novel norlathyrane diterpenes, named ekanpenoids A and B (1 and 2, resp.). Their structures were established by extensive 1D- and 2D-NMR spectroscopy, as well as other spectra. The isolated diterpenes exhibited potent cytotoxic activities against the HeLa and Hep-G2 cell lines with the IC50 values ranging from 3.6 to 9.7 μg/ml.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China, (phone: +86 25 52090620; fax: +86 25 52090618).
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Jiang
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Liu
authors.forename: Lan-Ju
authors.initials: LJ
authors.lastname: Ji
authors.forename: Hong-Fa
authors.initials: HF
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D028481:Euphorbia / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C588291:ekanpenoid A; C588292:ekanpenoid B
keywords: Cytotoxic activity; Diterpenes; Ekanpenoids A and B; Euphorbia kansuensis; Norlathyrane