title: CXCR4 in epidermal keratinocytes: crosstalk within the skin.
abstract: In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
authors.affiliation: Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA. Electronic address: WB@gru.edu.
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Bollag
authors.affiliation: Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Hill
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000276:immunology*; D005260:Female; D006801:Humans; D053760:Interleukin-23 Subunit p19 / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology*; D008297:Male; D019718:Receptors, CXCR4 / Q000276:immunology*
chemical_list: C527276:CXCR4 protein, human; C514936:CXCR4 protein, mouse; C508841:Il23a protein, mouse; D053760:Interleukin-23 Subunit p19; D019718:Receptors, CXCR4