title: Muir-Torre Syndrome in a Middle-Aged Chinese Patient with Sebaceous Carcinoma of the Eyelid.
abstract: Muir-Torre syndrome is a rare, autosomal dominant condition characterized by the presence of a skin tumor of sebaceous differentiation and visceral malignancies. We reviewed the case of a 46-year-old Chinese man who had a bleeding mass over the right upper eyelid. He had a history of colon cancer and a family history satisfying the Amsterdam criteria for hereditary non-polyposis colorectal cancer syndrome with germline mutation in the MutS homolog-2 gene. The eyelid lesion was excised completely and submitted for histopathologic examination which showed sebaceous carcinoma. Frozen section and conjunctival map biopsy showed no residual malignancy or local metastasis. Post-operative positron-emission tomography with combined computed tomography did not reveal any residual or visceral malignancy. He had no recurrence in the 32-month follow-up period. We should consider Muir-Torre syndrome in patients with sebaceous carcinoma, especially in the presence of personal and/or family history of visceral malignancies.
authors.affiliation: a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
authors.forename: Ching-Yuen
authors.initials: CY
authors.lastname: Wong
authors.affiliation: b Department of Ophthalmology , Queen Mary Hospital , Hong Kong , and.
authors.forename: Raymond Kai-Tat
authors.initials: RK
authors.lastname: Tang
authors.affiliation: a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
authors.forename: Robert Fung
authors.initials: RF
authors.lastname: Lam
authors.affiliation: a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
authors.forename: Ida Yu-Fong
authors.initials: IY
authors.lastname: Io
authors.affiliation: a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
authors.forename: Can Yin-Fun
authors.initials: CY
authors.lastname: Yuen
authors.affiliation: c Department of Surgery , Queen Mary Hospital , Hong Kong.
authors.forename: Judy Wai-Chu
authors.initials: JW
authors.lastname: Ho
authors.affiliation: a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
authors.forename: Raymond Kwok-Kay
authors.initials: RK
authors.lastname: Tse
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000473:pathology* / Q000601:surgery; D044466:Asian People / Q000208:ethnology; D002681:China / Q000453:epidemiology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000473:pathology; D005142:Eyelid Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D055653:Muir-Torre Syndrome / Q000175:diagnosis* / Q000601:surgery; D049268:Positron-Emission Tomography; D012626:Sebaceous Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
keywords: Eyelid; Muir-Torre syndrome; hereditary non-polyposis colorectal carcinoma; sebaceous carcinoma; sebaceous tumor