title: Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival.
abstract: Surgery and antifungals are the reference standard for rhino-orbito-cerebral mucormycosis (ROCM) treatment. The impact of local control on survival of 22 consecutive ROCM adults was studied on day 90: none vs. 75% died, respectively, with or without local control (p <0.0001). Hence, repeated surgical procedures are recommended to achieve local control of ROCM.
authors.affiliation: Service d'Oto-Rhino-Laryngologie, Hôpital Lariboisière, APHP, Université Paris 7, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Vironneau
authors.forename: R
authors.initials: R
authors.lastname: Kania
authors.forename: G
authors.initials: G
authors.lastname: Morizot
authors.forename: C
authors.initials: C
authors.lastname: Elie
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: P
authors.initials: P
authors.lastname: Herman
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: F
authors.initials: F
authors.lastname: Lanternier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001850:Bone Diseases, Infectious / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D001927:Brain Diseases / Q000382:microbiology / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D003646:Debridement / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000401:mortality / Q000628:therapy*; D009916:Orbital Diseases / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D010254:Paranasal Sinus Diseases / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D019291:Skull Base / Q000601:surgery; D015996:Survival Rate; D055815:Young Adult
chemical_list: D000935:Antifungal Agents
keywords: Local control; mucormycosis; necrosis; sinusitis; surgery