title: Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.
abstract: In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.
authors.affiliation: Department of Biotechnology, Zhengzhou University, Zhengzhou 450001, PR China.
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Wu
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Xu
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Dai
authors.forename: Meng-Jiao
authors.initials: MJ
authors.lastname: Liu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Wang
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Ming-Fu
authors.initials: MF
authors.lastname: Gao
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Nie
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Song
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Liu
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; C030419:andrographolide
keywords: Andrographolide; Derivative; Invasion; MMP-9; Migration