title: Anti-cancer evaluation of carboxamides of furano-sesquiterpene carboxylic acids from the soft coral Sinularia kavarattiensis.
abstract: The chemical investigation of soft coral Sinularia kavarattiensis is described. It yielded furano-sesquiterpene carboxylic acids 1 and 2 and their methyl esters 3 and 4. Semi-synthesis of furano-sesquiterpene carboxylic acid 1 gave amide derivatives 5-12. Structures of all the compounds were established by IR, NMR and mass spectral analysis. Interestingly all compounds are selectively potent on leukemia cell line. All these compounds were screened for cytotoxic activity against five human cancer cell lines (leukemia, prostate, lung, breast and cervix). Among these compounds 9 and 10 showed promising activity against leukemia and prostate cancer cell lines.
authors.affiliation: Division of Natural Products Chemistry, Toxicology Laboratory, CSIR-IICT, Hyderabad 500 007, India.
authors.forename: Singanaboina
authors.initials: S
authors.lastname: Rajaram
authors.forename: Udugu
authors.initials: U
authors.lastname: Ramulu
authors.forename: Dasari
authors.initials: D
authors.lastname: Ramesh
authors.forename: Dudem
authors.initials: D
authors.lastname: Srikanth
authors.forename: Papri
authors.initials: P
authors.lastname: Bhattacharya
authors.forename: Peddikotla
authors.initials: P
authors.lastname: Prabhakar
authors.forename: Shasi V
authors.initials: SV
authors.lastname: Kalivendi
authors.forename: Katragadda Suresh
authors.initials: KS
authors.lastname: Babu
authors.forename: Yenamandra
authors.initials: Y
authors.lastname: Venkateswarlu
authors.forename: Suryakiran
authors.initials: S
authors.lastname: Navath
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D005663:Furans; D012717:Sesquiterpenes
keywords: Cytotoxic activity; Furano-sesquiterpene carboxylic acid; Semi-synthesis; Sinularia kavarattiensis