title: Inflammatory myofibroblastic tumour in the nasal cavity of a dog.
abstract: A 4·5-year-old, female neutered Leonberger was presented with a 2-month history of sneezing, nasal discharge and epistaxis. A presumptive diagnosis of nasal aspergillosis was made based on a suspected (fungal) granuloma on rhinoscopic examination and fungal hyphae on cytological examination. A poor response to targeted therapy was observed and computed tomography 16 months after initial presentation revealed a progressive, locally invasive mass lesion. Histopathological and immunohistochemical analysis of deep surgical biopsies revealed a spindle cell population and a plasma cell rich inflammatory infiltrate, with diffuse expression of vimentin, supporting a diagnosis of inflammatory myofibroblastic tumour. Complete resolution of the nasal discharge and reduced sneezing frequency was reported 9 months post-surgical debridement via rhinotomy. To the authors' knowledge, this is the first report of IMT in the nasal cavity of a dog. IMT should be considered when presented with a nasal mass lesion, particularly if histopathological features and clinical course are inconsistent.
authors.affiliation: Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire.
authors.forename: F
authors.initials: F
authors.lastname: Swinbourne
authors.affiliation: Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire.
authors.forename: E
authors.initials: E
authors.lastname: Kulendra
authors.affiliation: Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hertfordshire.
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.affiliation: Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire.
authors.forename: C
authors.initials: C
authors.lastname: Leo
authors.affiliation: Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hertfordshire.
authors.forename: G
authors.initials: G
authors.lastname: Ter Haar
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D009296:Nasal Cavity / Q000473:pathology; D009668:Nose Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary