title: Acid neutralizing, mechanical and physical properties of pit and fissure sealants containing melt-derived 45S5 bioactive glass.
abstract: OBJECTIVE
  The aim of this study was to examine the effects of 45S5 bioactive glass (BAG) on the acid neutralizing, mechanical and physical properties of pit and fissure sealants.
  
  
  METHODS
  45S5BAG (<25 μm) was mixed with the silanized glass (180 ± 30 nm) and added into a resin matrix [Bis-GMA/TEGDMA 50/50 (wt%) containing 1% of DMAEMA/CQ 2:1 (wt%)] with varying filler proportions; 0% 45S5BAG+50% glass (BAG0); 12.5% 45S5BAG+37.5% glass (BAG12.5); 25% 45S5BAG+25% glass (BAG25); 37.5% 45S5BAG+12.5% glass (BAG37.5); and 50% 45S5BAG+0% glass (BAG50). To evaluate the acid neutralizing properties, specimens were immersed in lactic acid solution (pH 4.0). Then, the change in pH and the time required to raise the pH from 4.0 to 5.5 were measured. In addition, flexural strength, water sorption and solubility were analyzed.
  
  
  RESULTS
  The acid neutralizing properties of each group exhibited increasing pH values as more 45S5BAG was added, and the time required to raise the pH from 4.0 to 5.5 became shorter as the proportion of 45S5BAG increased (P<0.05). Additionally, the flexural strength decreased according to the increasing proportions of 45S5BAG added (P<0.05). Water sorption showed an increasing trend with increasing proportions of 45S5 BAG added (P<0.05). However, the solubility results were similar among the groups (P>0.05), except for BAG50.
  
  
  CONCLUSIONS
  The novel pit and fissure sealants neutralized the acid solution (pH 4.0) and exhibited appropriate mechanical and physical properties. Therefore, these compounds are suitable candidates for caries-inhibiting dental materials.
authors.affiliation: Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Yang
authors.forename: Yin-Zhu
authors.initials: YZ
authors.lastname: Piao
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Lee
authors.forename: Kyoung-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Kwang-Mahn
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000143:Acids / Q000737:chemistry*; D002516:Ceramics; D005898:Glass; D008422:Materials Testing; D010895:Pit and Fissure Sealants; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D000143:Acids; D010895:Pit and Fissure Sealants; C425330:bioactive glass 45S5; D014867:Water
keywords: 45S5 bioactive glass; Acid neutralizing property; Mechanical property; Physical property; Pit and fissure sealant