title: Cyclic lipopeptides as antibacterial agents - potent antibiotic activity mediated by intriguing mode of actions.
abstract: Cyclic lipopeptides (CLPs) are a promising class of natural products with antibiotic properties. CLPs are amphiphilic molecules, composed of a fatty acid tail linked to a short oligopeptide which form a macrocylic ring structure. This review presents an overview of this class of antibiotics, focusing on the current and potential therapeutic applications and placing particular emphasis on the molecular modes of action of these compounds.
authors.affiliation: Institute of Pharmaceutical Microbiology, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany. Electronic address: tanja@microbiology-bonn.de.
authors.forename: Tanja
authors.initials: T
authors.lastname: Schneider
authors.affiliation: Institute of Pharmaceutical Microbiology, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Müller
authors.affiliation: Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.
authors.forename: Henrike
authors.initials: H
authors.lastname: Miess
authors.affiliation: Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. Electronic address: harald.gross@uni-tuebingen.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic
keywords: Antibiotics; Cyclic lipopeptides; Daptomycin; Mode of action; Polymyxin