title: Feasibility of left ventricular volume measurements by three-dimensional speckle tracking echocardiography depends on image quality and degree of left ventricular enlargement: validation study with cardiac magnetic resonance imaging.
abstract: BACKGROUND
  Novel 3-dimensional echocardiography with speckle tracking imaging (3D-STE) may have advantages in assessing left ventricular (LV) volume through a cardiac cycle. The feasibility of 3D-STE may be affected by image quality and LV morphology.
  
  
  RESULTS
  We studied 64 patients (38 men, age 55±12 years) who underwent cardiac magnetic resonance imaging (CMRI) and 3D-STE on the same day. LV end-diastolic volume (EDV) and end-systolic volume (ESV) were measured by both modalities. Imaging qualities were quantified in each of 6 LV segments by an imaging quality score (IQS) of 1-3, and scores were averaged (mean IQS) at end-diastole and end-systole. Compared to CMRI, 3D-STE showed a tendency to underestimate LV volume measurements, but not significantly (EDV: bias=-18±37ml; ESV: bias=-10±34ml), and measurements correlated well with those by CMRI (EDV: R=0.80, ESV: R=0.86, ejection fraction: R=0.75, p<0.001). The absolute differences of LVEDV and ESV between 3D-STE and CMRI correlated significantly with mean IQS (LVEDV, R=-0.35, p=0.005; LVESV, R=-0.30, p=0.02). Based on the medium value of LVEDV by CMRI (127ml), subjects were classified into the small (<127ml) and large LVEDV (≧127ml) groups. In the large LVEDV group, mean IQS significantly correlated with the absolute differences of LVEDV (mean IQS, r=-0.45, p=0.01), despite no significant correlation in the small LVEDV group.
  
  
  CONCLUSIONS
  3D-STE could measure LV volume as well as CMRI, however, its accuracy depends on the quality of the acquired image and particularly on enlargement of the left ventricle.
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Kawamura
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan. Electronic address: yo-seo@md.tsukuba.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Seo
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishizu
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Atsumi
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Machino-Ohtsuka
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sakai
authors.affiliation: Department of Radiology, University of Tsukuba, Tsukuba, Japan.
authors.forename: Yumiko Oishi
authors.initials: YO
authors.lastname: Tanaka
authors.affiliation: Department of Radiology, University of Tsukuba, Tsukuba, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Minami
authors.affiliation: Cardiovascular Division, University of Tsukuba, Tsukuba, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
mesh_terms: D000328:Adult; D000368:Aged; D002306:Cardiac Volume; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
keywords: 3-Dimensional echocardiography; Magnetic resonance imaging; Speckle tracking echocardiography; Ventricular function