title: Lack of association between LIPC-514 C/T polymorphism of hepatic lipase and endometriosis in Iranian women.
abstract: OBJECTIVE
  Patients with endometriosis may suffer from dyslipidemia. Hepatic lipase (HL) is involved in the metabolism of lipoproteins and has an important role in reverse cholesterol transport. The aim of this study was to investigate the association between the LIPC-514 C/T polymorphism in the HL gene and the risk of endometriosis in a group of Iranian women.
  
  
  METHODS
  Ninety-seven patients with endometriosis and 107 women who were negative for endometriosis after diagnostic laparoscopy, as control group, were enrolled in this cross-sectional study. Samples were analyzed for polymorphism of the HL gene using polymerase chain reaction restriction fragment length polymorphism.
  
  
  RESULTS
  Multivariate analysis was used to examine the association between the risk of endometriosis and LIPC-514 C/T polymorphism. There was no statistically significant difference in the frequency of the LIPC-514 C/T polymorphism between patients and the controls (60.7% CC, 34.6% CT, 4.7% TT versus 68.4%, 27.4%, 4.2%, respectively, P = 0.52).
  
  
  CONCLUSIONS
  The present study suggested that the LIPC-514 C/T polymorphism of the HL gene has no significant association with the risk of endometriosis in the studied Iranian women.
authors.affiliation: Department of Clinical Biochemistry, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sahmani
authors.forename: Talaat Dabbaghi
authors.initials: TD
authors.lastname: Ghaleh
authors.forename: Maryam
authors.initials: M
authors.lastname: Darabi
authors.forename: Masoud
authors.initials: M
authors.lastname: Darabi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rashvand
authors.forename: Reza
authors.initials: R
authors.lastname: Najafipour
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D007492:Iran; D008049:Lipase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C504173:LIPC protein, human; D008049:Lipase
keywords: LIPC-514 C/T polymorphism; dyslipidemia; endometriosis; hepatic lipase