title: Esophageal cancer presenting as a brain metastasis: A case report.
abstract: Carcinoma of unknown primary origin (CUP) is defined as the histological diagnosis of metastasis without the detection of a primary tumor. The incidence of CUP in all patients with a malignant disease has been reported to be between 3 and 15%. Esophageal cancer is the third most common type of cancer of the digestive tract and the seventh most common cause of cancer-related mortality worldwide. The overall incidence of the disease is highest in males >50 years old. Brain metastases have been reported in only 1.7-3.6% of all patients with different types of esophageal cancer. Brain metastasis as the presenting form of esophageal carcinoma is highly uncommon. The present study reports the case of a patient with an unknown primary tumor who presented with a cerebral metastasis, without extra-neurological symptoms. The CUP was subsequently diagnosed as an esophageal carcinoma.
authors.affiliation: Section of Neurosurgery, Department of Clinical Neurosciences, Neurological Centre of Latium (NCL), Rome I-00178, Italy ; Department of Biomedicine, University of Rome 'Tor Vergata', Rome I-00173, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Spallone
authors.forename: Chiara
authors.initials: C
authors.lastname: Izzo
keywords: brain metastasis; esophageal cancer; unknown primary carcinoma