title: Next-generation sequencing in schizophrenia and other neuropsychiatric disorders.
abstract: Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA; Mental Health Services, VA Puget Sound Health Care System, Seattle, WA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Schreiber
authors.forename: Michael
authors.initials: M
authors.lastname: Dorschner
authors.forename: Debby
authors.initials: D
authors.lastname: Tsuang
mesh_terms: D055106:Genome-Wide Association Study; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008957:Models, Genetic; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
keywords: autism; genetics; schizophrenia; sequencing; whole exome