title: Pathogenesis of neurotoxicity of acrylates acrylonitrile and acrylamide: from cell to organism.
abstract: The incubation of 10 mM acrylamide (in vitro) with rat brain homogenate was followed by a decrease in catalase activity by 48% as soon as 5 min after addition of acrylate to the incubation medium. Activity of this enzyme remained low 30 min after the start of the experiment. Acute poisoning with this acrylate was accompanied by LPO activation in rat brain 24 h after injection. Exposure to acrylonitrile during occupational contacts with this monomer was followed by accumulation of adducts of acrylate with erythrocytic hemoglobin in human blood. In accordance with previously observed data, modern scheme of neurotropic effects of acrylonitrile and acrylamide was proposed. This scheme explained specific features of clinical syndromes induced by acute and chronic exposure to these toxic agents.
authors.affiliation: Research Center for Family Health Problems and Human Reproduction, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia. mtarskikh@mail.ru.
authors.forename: M M
authors.initials: MM
authors.lastname: Tarskikh
authors.forename: L G
authors.initials: LG
authors.lastname: Klimatskaya
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
mesh_terms: D020106:Acrylamide / Q000633:toxicity*; D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D021461:Animals, Outbred Strains; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D007928:Lethal Dose 50; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000378:metabolism; D016273:Occupational Exposure; D051381:Rats; D017382:Reactive Oxygen Species / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D017382:Reactive Oxygen Species; D020106:Acrylamide; D008315:Malondialdehyde; D002374:Catalase; D000181:Acrylonitrile