title: Porous media properties of reticulated shape memory polymer foams and mock embolic coils for aneurysm treatment.
abstract: BACKGROUND
  Shape memory polymer (SMP) foams are being investigated as an alternative aneurysm treatment method to embolic coils. The goal of both techniques is the reduction of blood flow into the aneurysm and the subsequent formation of a stable thrombus, which prevents future aneurysm rupture. The purpose of this study is to experimentally determine the parameters, permeability and form factor, which are related to the flow resistance imposed by both media when subjected to a pressure gradient.
  
  
  METHODS
  The porous media properties-permeability and form factor-of SMP foams and mock embolic coils (MECs) were measured with a pressure gradient method by means of an in vitro closed flow loop. We implemented the Forchheimer-Hazen-Dupuit-Darcy equation to calculate these properties. Mechanically-reticulated SMP foams were fabricated with average cell sizes of 0.7E-3 and 1.1E-3 m, while the MECs were arranged with volumetric packing densities of 11-28%.
  
  
  RESULTS
  The permeability of the SMP foams was an order of magnitude lower than that of the MECs. The form factor differed by up to two orders of magnitude and was higher for the SMP foams in all cases. The maximum flow rate of all samples tested was within the inertial laminar flow regime, with Reynolds numbers ranging between 1 and 35.
  
  
  CONCLUSIONS
  The SMP foams impose a greater resistance to fluid flow compared to MECs, which is a result of increased viscous and inertial losses. These results suggest that aneurysms treated with SMP foam will have flow conditions more favorable for blood stasis than those treated with embolic coils having packing densities ≤ 28%.
authors.affiliation: Texas A&M University, 3120 TAMU, 77843 College Station, Texas, USA. djmaitland@tamu.edu.
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Muschenborn
authors.forename: Jason M
authors.initials: JM
authors.lastname: Ortega
authors.forename: Jason M
authors.initials: JM
authors.lastname: Szafron
authors.forename: David J
authors.initials: DJ
authors.lastname: Szafron
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maitland
mesh_terms: D057510:Endovascular Procedures / Q000295:instrumentation*; D057446:Hydrodynamics; D002532:Intracranial Aneurysm / Q000601:surgery; D010539:Permeability; D011108:Polymers; D016062:Porosity
chemical_list: D011108:Polymers