title: Effect of substituent of terpyridines on the in vitro antioxidant, antitubercular, biocidal and fluorescence studies of copper(II) complexes with clioquinol.
abstract: An octahedral complexes of copper with clioquinol(CQ) and substituted terpyridine have been synthesized. The Cu(II) complexes have been characterized by elemental analyses, thermogravimetric analyses, magnetic moment measurements, FT-IR, electronic, (1)HNMR and FAB mass spectra. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. Ferric-reducing anti-oxidant power of all complexes were measured. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity.
authors.affiliation: Department of Chemistry, Navjivan Science College, Gujarat University, Dahod 389151, Gujarat, India. Electronic address: gaurangkharadi@yahoo.com.
authors.forename: G J
authors.initials: GJ
authors.lastname: Kharadi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D007464:Clioquinol / Q000737:chemistry* / Q000378:metabolism; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005453:Fluorescence; D066298:In Vitro Techniques; D008280:Magnetics; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D000995:Antitubercular Agents; D056831:Coordination Complexes; D011725:Pyridines; D003300:Copper; D007464:Clioquinol
keywords: 4′-(4-bromophenyl)-2,2′:6′,2′′-terpyridine; 4′-(4-fluorophenyl)-2,2′:6′,2′′–terpyridine; 4′-(4-methoxyphenyl)-2,2′:6′,2′′-terpyridine; Antioxidant; Antituberculosis; B.M.; Biocidal activity; Bohr magneton; C(1); C(2); C(3); CQ; Copper(II); Fluorescence; L; L(1); L(1), L(2), L(3); L(2); L(3); LB; Luria Broth; TGA; [Cu(L(1))(CQ)Cl]⋅3H(2)O; [Cu(L(2))(CQ)Cl]⋅H(2)O; [Cu(L(3))(CQ)Cl]⋅2H(2)O; clioquinol; thermogravimetric analysis