title: [Role of small-dose recombinant human coagulation factor VIIa for coagulopathy in patients with isolated traumatic brain injury].
abstract: OBJECTIVE
  To explore the role of small-dose recombinant human coagulation factor VIIa (rFVIIa) for coagulopathy in patients with isolated traumatic brain injury.
  
  
  METHODS
  A total of 86 isolated traumatic brain patients with coagulopathy were treated at our neurosurgery intensive care unit (NICU) from January 2010 to December 2012. Their trauma registry data included mortality, pre-and post-rFVIIa coagulation parameters. Two-tailed paired t-test was used to determine significant changes in coagulation parameters and other major clinical parameters.
  
  
  RESULTS
  Twenty-seven patients made up the low-dose rFVIIa (20 µg/kg) group. And the control group had 59 well-matched subjects. At admission, age, blood pressure, Glasgow coma scale score, hemoglobin, platelets and international normalize ratio were similar in both groups. After treatment, the INR of patients on rFVIIa was lower than that of the conventional treatment group (1.1 ± 0.2 vs 1.2 ± 0.2, P < 0.01) and it declined more in the rFVIIa group (0.3 ± 0.2 vs 0.1 ± 0.4, P = 0.05). No significant difference existed in mortality or length of stay between two groups.There was no occurrence of subsequent thromboembolic events.
  
  
  CONCLUSIONS
  The application of small-dose rFVIIa can effectively reduce the value of INR and improve the coagulation status of patients. During the course of treatment, no major adverse events occur.
authors.affiliation: Department of Neurosurgery, Affiliated Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Bing-bing
authors.initials: BB
authors.lastname: Pei
authors.forename: Chao-yue
authors.initials: CY
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.forename: Xue-hai
authors.initials: XH
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
authors.forename: Yi-rui
authors.initials: YR
authors.lastname: Sun
authors.forename: Zhuo-ying
authors.initials: ZY
authors.lastname: Du
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Jin
authors.initials: J
authors.lastname: Hu
authors.forename: Liang-fu
authors.initials: LF
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D015942:Factor VIIa / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa