title: Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers.
abstract: BACKGROUND
  Salacia chinensis (S. chinensis) is widely distributed in India and Sri Lanka. Most of the species of genus Salacia are known to have effects on blood glucose levels; however, the effects of S. chinensis on glucose levels are seldom reported.
  
  
  OBJECTIVE
  To evaluate the oral hypoglycemic activity of NR- Salacia (1000 mg extract of S. chinensis) in healthy adults.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled, cross-over study was conducted in healthy volunteers. Single dose of NR-Salacia (1000 mg extract of Salacia chinensis) and placebo were administered before carbohydrate-rich diet. A 6-point plasma glucose profile was performed at different time intervals up to 180 min.
  
  
  RESULTS
  NR-Salacia treatment significantly lowered plasma glucose level at 90 min, and the percentage reduction in glucose concentration was found to be 13.32 as compared to placebo group. A 33.85% decrease in the plasma glucose positive incremental area under curve (AUC) (0 to 180 min) was observed in comparison to placebo. No adverse events were recorded throughout the study period, except for some mild cases of abdominal discomforts like cramping and distention, vomiting, and headache in both placebo and NR-Salacia-treated groups.
  
  
  CONCLUSIONS
  The study findings revealed that NR-Salacia lowered the post-prandial plasma glucose levels after a carbohydrate-rich meal and can be used as an oral hypoglycemic agent.
authors.affiliation: Clinical Pharmacology, Institute of Clinical Research (India), Bangalore, India.
authors.forename: Pravina
authors.initials: P
authors.lastname: Koteshwar
authors.forename: Kadur Ramamurthy
authors.initials: KR
authors.lastname: Raveendra
authors.forename: Joseph Joshua
authors.initials: JJ
authors.lastname: Allan
authors.forename: Krishnagouda Shankargouda
authors.initials: KS
authors.lastname: Goudar
authors.forename: Kudiganti
authors.initials: K
authors.lastname: Venkateshwarlu
authors.forename: Amit
authors.initials: A
authors.lastname: Agarwal
keywords: Carbohydrate-rich diet; Salacia chinensis; cross-over; double-blind placebo controlled; hypoglycemic; post-prandial glucose