title: Human health risk assessment of lead from mining activities at semi-arid locations in the context of total lead exposure.
abstract: Lead from historical mining and mineral processing activities may pose potential human health risks if materials with high concentrations of bioavailable lead minerals are released to the environment. Since the Joint Expert Committee on Food Additives of Food and Agriculture Organization/World Health Organization withdrew the Provisional Tolerable Weekly Intake of lead in 2011, an alternative method was required for lead exposure assessment. This study evaluated the potential lead hazard to young children (0-7 years) from a historical mining location at a semi-arid area using the U.S. EPA Integrated Exposure Uptake Biokinetic (IEUBK) Model, with selected site-specific input data. This study assessed lead exposure via the inhalation pathway for children living in a location affected by lead mining activities and with specific reference to semi-arid conditions and made comparison with the ingestion pathway by using the physiologically based extraction test for gastro-intestinal simulation. Sensitivity analysis for major IEUBK input parameters was conducted. Three groups of input parameters were classified according to the results of predicted blood concentrations. The modelled lead absorption attributed to the inhalation route was lower than 2 % (mean ± SE, 0.9 % ± 0.1 %) of all lead intake routes and was demonstrated as a less significant exposure pathway to children's blood, compared with ingestion. Whilst dermal exposure was negligible, diet and ingestion of soil and dust were the dominant parameters in terms of children's blood lead prediction. The exposure assessment identified the changing role of dietary intake when house lead loadings varied. Recommendations were also made to conduct comprehensive site-specific human health risk assessment in future studies of lead exposure under a semi-arid climate.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zheng
authors.forename: Trang
authors.initials: T
authors.lastname: Huynh
authors.forename: Massimo
authors.initials: M
authors.lastname: Gasparon
authors.forename: Jack
authors.initials: J
authors.lastname: Ng
authors.forename: Barry
authors.initials: B
authors.lastname: Noller
mesh_terms: D001315:Australia; D002648:Child; D002675:Child, Preschool; D004032:Diet / Q000706:statistics & numerical data; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007854:Lead / Q000032:analysis* / Q000378:metabolism; D008906:Mining; D008956:Models, Chemical; D052638:Particulate Matter / Q000032:analysis; D018570:Risk Assessment; D012987:Soil / Q000737:chemistry
chemical_list: D004391:Dust; D004785:Environmental Pollutants; D052638:Particulate Matter; D012987:Soil; D007854:Lead