title: Pathomorphosis of experimental infection in mice, infected by Streptococcus pneumoniae, under the effect of immunotropic drugs.
abstract: Pathomorphological changes in the organs of animals intranasally infected with Streptococcus pneumoniae were studied under conditions of immunotropic therapy added to antibiotic therapy. The pathomorphosis in the lungs, spleen, and thymus in animals treated with likopid, tinrostim, and roncoleukin was described. A positive time course of the pathological process in experimental animals in comparison with intact animals and animals receiving no immunotropic drugs was demonstrated.
authors.affiliation: Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia. l_somova@mail.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.forename: N M
authors.initials: NM
authors.lastname: Kondrashova
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.forename: E I
authors.initials: EI
authors.lastname: Drobot
authors.forename: I N
authors.initials: IN
authors.lastname: Lyapun
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D021461:Animals, Outbred Strains; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001372:Aza Compounds / Q000494:pharmacology / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000276:immunology; D019587:Dietary Supplements; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D024841:Fluoroquinolones; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007376:Interleukin-2 / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D000077266:Moxifloxacin; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000276:immunology; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013296:Streptococcus pneumoniae
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007155:Immunologic Factors; D007376:Interleukin-2; D011804:Quinolines; C089161:glikopin; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000077266:Moxifloxacin