title: Neuroprotective effects of individual or combined exposure to hypoxia and hypercapnia in the experiment.
abstract: We studied the effects of hypoxic, hypercapnic, and hypercapnic-hypoxic exposures on brain tolerance to ischemia. All respiratory training modes had a neuroprotective effect, but the most pronounced effect was observed after exposure to hypercapnic hypoxia. Experimental stroke in rats preliminary exposed to hypercapnic hypoxia was associated with minimal neurological deficit and motor coordination disturbances in comparison with training modes.
authors.affiliation: Altai State Medical University, Ministry of Health and Social Development of the Russian Federation, Barnaul, Russia. pfiza_asmu@mail.ru.
authors.forename: P P
authors.initials: PP
authors.lastname: Tregub
authors.forename: V P
authors.initials: VP
authors.lastname: Kulikov
authors.forename: A G
authors.initials: AG
authors.lastname: Bespalov
authors.forename: A Ju
authors.initials: AJ
authors.lastname: Vvedensky
authors.forename: I S
authors.initials: IS
authors.lastname: Osipov
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology*; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D007511:Ischemia / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010100:Oxygen / Q000008:administration & dosage; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D018709:Statistics, Nonparametric
chemical_list: D018696:Neuroprotective Agents; D002245:Carbon Dioxide; D010100:Oxygen