title: Advances towards the prevention of meningococcal B disease: a multidimensional story.
abstract: Whilst much progress has been made in reducing the burden of bacterial meningitis and septicaemia through vaccination, endemic serogroup B meningococcal (MenB) disease has remained problematic. Polysaccharide-protein conjugate vaccines are now available to protect against Haemophilus influenzae type b, Neisseria meningitidis serogroups A, C, Y and W and thirteen serotypes of Streptococcus pneumoniae, but this approach has not been used for MenB. Instead efforts have been made to identify protein antigens which, when used in vaccines, will prevent MenB infection and possibly disease due to other serogroups too. The first such vaccine has recently been licensed.
authors.affiliation: Bristol Royal Hospital for Children, Bristol, UK. Electronic address: Marion.Roderick@UHBristol.nhs.uk.
authors.forename: Marion
authors.initials: M
authors.lastname: Roderick
authors.forename: Adam
authors.initials: A
authors.lastname: Finn
mesh_terms: D017277:Drug Approval; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D008585:Meningitis, Meningococcal / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification*; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology / Q000302:isolation & purification*
chemical_list: C570015:4CMenB vaccine; D022401:Meningococcal Vaccines
keywords: Meningococcal; Neisseria meningitidis; Serogroup B; Vaccination