title: Comparison of OCT measurements between high myopic and low myopic children.
abstract: OBJECTIVE
  To compare the peripapillary retinal nerve fiber layer (RNFL) thickness, macular thickness, and total macular volume of high myopic eyes with those of low myopic eyes in children younger than 10 years.
  
  
  METHODS
  Prospective, randomized, comparative study. Time-domain optical coherence tomography (OCT) (Stratus OCT; Carl Zeiss Meditec) was performed on 15 children with high myopia (refractive error greater than or equal to -6.0 diopters [D], group 1) and 20 children with low myopia (0 less than refractive error from -0.25 to -3.0 D, group 2). Fast RNFL scan and a fast macular scan with OCT were performed in both groups. The authors compared the data between the two groups.
  
  
  RESULTS
  The mean age of the patients with high myopia was 7.8 years and that of those with low myopia was 7.2 years. The mean overall thickness of the peripapillary RNFL was 100.8 μm in the high myopes and 110.5 μm in the low myopes. There was a statistically significant difference in the overall RNFL thickness between the two groups (p < 0.05). In addition, peripapillary RNFL thinning was especially prominent in the inferior quadrant in children with high myopia (p = 0.021). The mean values of macula thickness and volume for high myopes were also significantly smaller than the mean values for low myopes (p < 0.05).
  
  
  CONCLUSIONS
  The inferior quadrant and the overall peripapillary RNFL were significantly thinner in high myopic children relative to low myopic children. High myopic children had significantly thinner macular thickness and lower macular volumes. These structural differences should be considered in the clinical assessment of high myopic children.
authors.affiliation: *MD, PhD Department of Ophthalmology, Asan Medical Center Hospital, Seoul, Korea (H-TL); and Department of Ophthalmology, Kyungpook National University, School of Medicine, Daegu, Korea (BYC).
authors.forename: Hyun-Taek
authors.initials: HT
authors.lastname: Lim
authors.forename: Bo Young
authors.initials: BY
authors.lastname: Chun
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009216:Myopia / Q000175:diagnosis; D047728:Myopia, Degenerative / Q000175:diagnosis*; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology