title: Polymorphic AAAG repeat length in estrogen-related receptor gamma (ERRγ) and risk of breast cancer in Iranian women.
abstract: Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ERRγ gene, a case-control study of 200 breast cancer patients and 200 controls was performed in Iranian women. Our results demonstrate that women with short AAAG repeat are at higher risk of breast cancer (OR 7). This result suggests a possible involvement of polymorphic AAAG repeat of ERRγ gene in regulating its expression.
authors.affiliation: Department of Biology, Faculty of Sciences, University of Isfahan, Hezar-Jarib, Isfahan, Iran,1.
authors.forename: Padideh
authors.initials: P
authors.lastname: Karimi
authors.forename: Simin
authors.initials: S
authors.lastname: Hematti
authors.forename: Foruzan
authors.initials: F
authors.lastname: Safari
authors.forename: Manoochehr
authors.initials: M
authors.lastname: Tavassoli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D007492:Iran / Q000453:epidemiology; D018895:Microsatellite Repeats; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*; D012307:Risk Factors
chemical_list: C490917:ESRRG protein, human; D011960:Receptors, Estrogen