title: Association of self-monitoring of blood glucose use on glycated hemoglobin and weight in newly diagnosed, insulin-naïve adult patients with type 2 diabetes.
abstract: BACKGROUND
  Clinical trials have shown that self-monitoring of blood glucose (SMBG) combined with patient education and medication titration can lead to improved glycated hemoglobin (HbA1c) and reduced weight in recently diagnosed non-insulin-treated type 2 diabetes mellitus (T2DM) patients. This retrospective matched cohort study assessed the association of SMBG with achieving long-term clinical outcomes in these patients in a real-world clinical setting.
  
  
  METHODS
  Using electronic medical records (2008-2011), we selected a population of adult patients recently diagnosed with T2DM not receiving insulin who were SMBG users and a population of non-SMBG controls with similar demographic and clinical characteristics using propensity score matching. The main study outcomes compared between the two groups were time to achieve (1) HbA1c <7% for patients with baseline HbA1c ≥ 7% and (2) a ≥ 5% reduction in weight from baseline.
  
  
  RESULTS
  Of the 589 patients identified in each group, 113 in each group had a baseline HbA1c ≥ 7% (mean, 8.2%). The SMBG users were more likely to achieve an HbA1c <7% (12 months: 58.4% versus 38.9%, p = .0037; 36 months: 84.0% versus 70.0%, p = .0013) and to do so faster (median, 6.5 versus 20.5 months; log-rank p = .0016). Self-monitoring of blood glucose was associated with faster weight reduction (median time to achieve a ≥ 5% reduction, 23.5 versus 35.9 months for SMBG and non-SMBG, respectively; log-rank p = .0005).
  
  
  CONCLUSIONS
  In newly diagnosed T2DM insulin-naïve patients, SMBG users had an improved rate of achieving long-term glycemic control and weight loss in a real-world clinical setting.
authors.affiliation: LifeScan, Inc., 1000 Gibraltar Dr., Milpitas, CA 95035. nvirdi@its.jnj.com.
authors.forename: Naunihal S
authors.initials: NS
authors.lastname: Virdi
authors.forename: Patrick
authors.initials: P
authors.lastname: Lefebvre
authors.forename: Hélène
authors.initials: H
authors.lastname: Parisé
authors.forename: Mei Sheng
authors.initials: MS
authors.lastname: Duh
authors.forename: Dominic
authors.initials: D
authors.lastname: Pilon
authors.forename: François
authors.initials: F
authors.lastname: Laliberté
authors.forename: Devi
authors.initials: D
authors.lastname: Sundaresan
authors.forename: Lawrence
authors.initials: L
authors.lastname: Garber
authors.forename: Riad
authors.initials: R
authors.lastname: Dirani
mesh_terms: D000328:Adult; D000368:Aged; D015190:Blood Glucose Self-Monitoring; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D015431:Weight Loss
chemical_list: D006442:Glycated Hemoglobin