title: Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice.
abstract: Wound tissue repair is a complex and dynamic process of restoring cellular structures and tissue layers. Improvement of this process is crucial for several pathologies characterized by chronic delayed wound closure such as diabetes, and the investigation of new approaches aimed to ameliorate the wound healing process is under continuous evolution. Recently, the usage of vegetable matrices in the form of ozonated oils has been proposed and several researchers have shown a positive effect in the wound, based on their bactericidal, antiviral, and antifungal properties. The present study was undertaken to compare the effect that different ozonated oils (olive, sesame and linseed) with the same level of ozonation have on wound healing rate in SKH1 mice. Several histological parameters and the level of key proteins such as VEGF and PCNA have been analyzed. Only treatment with ozonated sesame oil shows a faster wound closure in the first 7 days. This effect paralleled with the increased VEGF and PCNA levels, NFκB nuclear translocation and 4-HNE formation. The present study shows that not only the ozonation grade is of importance for the improvement of wound healing process but also the typical composition of the oil.
authors.affiliation: Dipartimento di Scienze della Vita e Biotecnologie, Università degli Studi di Ferrara, Italy; Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea. Electronic address: giuseppe.valacchi@unife.it.
authors.forename: G
authors.initials: G
authors.lastname: Valacchi
authors.forename: I
authors.initials: I
authors.lastname: Zanardi
authors.forename: Y
authors.initials: Y
authors.lastname: Lim
authors.forename: G
authors.initials: G
authors.lastname: Belmonte
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: C
authors.initials: C
authors.lastname: Sticozzi
authors.forename: V
authors.initials: V
authors.lastname: Bocci
authors.forename: V
authors.initials: V
authors.lastname: Travagli
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D005260:Female; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D016328:NF-kappa B; D010938:Plant Oils; D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A; D003094:Collagen
keywords: 1,2,4-Trioxolane moiety; Prodrugs; Vegetable matrices; Wound healing