title: Concise review: Sowing the seeds of a fruitful harvest: hematopoietic stem cell mobilization.
abstract: Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies.
authors.affiliation: Harvard University, Department of Stem Cell and Regenerative Biology, Massachusetts General Hospital, Center for Regenerative Medicine, Harvard Stem Cell Institute, Boston, Massachusetts, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hoggatt
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Speth
authors.forename: Louis M
authors.initials: LM
authors.lastname: Pelus
mesh_terms: D000818:Animals; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D055153:Stem Cell Niche
keywords: AMD3100 (plerixafor); CXCR4; Granulocyte-colony stimulating factor; Hematopoietic stem cell; Mobilization; Stem cell niche