title: Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions.
abstract: OBJECTIVE
  Patients with inherited bleeding disorders are at high risk of bleeding following oral surgery and present challenges to the oral surgeons. Aim of this study was to report our experience in dental extraction in patients exhibiting Haemophilia A and B between 2007 and 2012.
  
  
  METHODS
  58 dental extractions in 15 patients during 19 interventions were performed. Replacement therapy with recombinant and plasma-derived factor VIII and IX was applied systematically in combination with antifibrinolytic treatment and local haemostatic measures. The following data were recorded: type of surgery, applied local haemostatic measures, general substitution, systemic antifibrinolytic agents and occurrence of postoperative bleeding complications.
  
  
  RESULTS
  Two patients presented postoperative bleeding. One had secondary bleeding requiring additional injection of factor concentrates. The other one presented epistaxis which was managed conservatively with a nasal tamponade.
  
  
  CONCLUSIONS
  Excellent haemostasis is achievable after dental extractions in patients with Haemophilia A and B by following a protocol using defined pre- and postoperative doses of factor concentrates in combination with haemostatic measures.
authors.affiliation: Department of Cranio-Maxillofacial, Plastic Surgery, Friedrich Schiller University Jena, Universitätsklinikum Jena, D-07747 Jena, Germany, andre.peisker@med.uni-jena.de.
authors.forename: Andre
authors.initials: A
authors.lastname: Peisker
authors.forename: Gregor-Franziskus
authors.initials: GF
authors.lastname: Raschke
authors.forename: Stefan
authors.initials: S
authors.lastname: Schultze-Mosgau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology* / Q000517:prevention & control*; D014081:Tooth Extraction; D055815:Young Adult
chemical_list: D006490:Hemostatics