title: CD46: the 'multitasker' of complement proteins.
abstract: Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose.
authors.affiliation: Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London SE1 9RT, UK; The Urology Centre, Guy's and St. Thomas' NHS Foundations Trust, London SE1 9RT, UK.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Antonella Francesca
authors.initials: AF
authors.lastname: Fara
authors.forename: Prokar
authors.initials: P
authors.lastname: Dasgupta
authors.forename: Claudia
authors.initials: C
authors.lastname: Kemper
mesh_terms: D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051916:Membrane Cofactor Protein / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D051916:Membrane Cofactor Protein; D003165:Complement System Proteins
keywords: (CBF1/Su(H)/Lag-1) transcription factor complex; ADAM; AMD; AP-1; Autoimmunity; B-cell lymphoma 2; Bcl-2; CCL; CCP; CD46; CD46 cytoplasmic domain 1 or 2; CSL; CYT-1 or CYT-2; Complement; DC; DLG4; DLL; ERK1/2; FLT3; FLT3L; FMS-related tyrosine kinase 3; FMS-related tyrosine kinase 3 ligand; G protein-coupled receptor; G protein-coupled receptor kinase; GAS; GATA3; GOPC; GPCR; GRK; GSK3β; GTP; Group A Streptococcus pyogenes; ICER/CREM; IFN; IL; IPEX; IS; Infection; JAK; JNK; Janus kinase; LAT; LDL receptor-related protein; LEF; LRP; Lck; MAPK; MHC; MMP; MS; MTOC; NF-κB; NICD; NO; Notch intracellular domain; PGE2; RA; RCA; SLE; SNP; SP-1; SPAK; STAT; STP region; Ste20/SPS-1-related kinase; T cell receptor; T helper cell/response; T-bet; T-box transcription factor TBX21; T-cell factor/lymphocyte-enhancer-binding factor; TCR; TER; TLR; Th; Th1 cells; Toll-like receptor; UT; a disintegrin and metalloproteinase; aHUS; activator protein 1; age-related macular degeneration; atypical hemolytic uremic syndrome; c-Jun amino-terminal kinase; chemokine (C-C motif) ligand; complement control protein domain; delta-like ligand; dendritic cell; extracellular signal-regulated protein kinases 1 and 2; glycogen synthase kinase 3β; golgi-associated PDZ and coiled-coil motif-containing protein; guanine triphosphate; human homologue of Discs Large (DLG) Drosophila; immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like; immunological synapse; inducible cAMP early repressor/cAMP response element modulator; interferon; interleukin; linker for activation of T cells; lymphocyte-specific protein tyrosine kinase; major histocompatibility complex; matrix metalloproteinase; microtubule organizing centre; mitogen-activated protein kinase; multiple sclerosis; nTreg; natural regulatory T cell; nitric oxide; nuclear factor kappa-light-chain-enhancer of activated B cells; prostaglandin E2; regulators of complement activity; rheumatoid arthritis; serine, threonine, proline-rich region; signal transducer and activator of transcription; single-nucleotide polymorphism; specificity protein 1; systemic lupus erythematosus; trans-acting T-cell-specific transcription factor GATA3; transepithelial resistance; untranslated region