title: Expression and clinicopathological significance of CD9 in gastrointestinal stromal tumor.
abstract: This study investigated the expression and clinicopathological significance of CD9 in gastrointestinal stromal tumor (GIST). Immunohistochemistry staining for CD9 was performed on tumor tissues from 74 GIST patients. The correlation with clinicopathological features, risk classification and prognosis was analyzed. CD9-positive staining comprised 59.5% (44/74) of the GIST patients. The CD9-positive expression rate of the sample was significantly associated with diameter (P = 0.028), mitotic counts (P = 0.035), risk classification (P = 0.018) and three-year recurrence-free survival (RFS) (P < 0.001). Cox proportional hazards regression (HR = 0.352; P = 0.015) showed that CD9 is an independent factor for post-operative RFS. The subgroup analysis showed that CD9 expression in gastric stromal tumor (GST) is significantly associated with diameter (P = 0.031), risk classification (P = 0.023) and three-year RFS (P = 0.001). The Cox proportional hazards regression (HR = 0.104; P = 0.006) also showed that CD9 is an independent factor for RFS of GST. However, CD9 expression does not have a statistically significant correlation with clinicopathological features, risk classification, and prognosis in non-GST. In conclusion, CD9 expression in GIST appears to be associated with the recurrence and/or metastasis of GIST patients, especially in GST, which may indicate the important role of CD9 in the malignant biological behavior and prognosis of GST.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. ; Department of Gastrointestinal Surgery of the Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou Province, China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Yang
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Shen
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Haining
authors.initials: H
authors.lastname: Chen
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Chen
authors.forename: Jiaping
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D060245:Tetraspanin 29 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D060245:Tetraspanin 29
keywords: CD9; Gastric Stromal Tumor; Gastrointestinal Stromal Tumors; Immunohistochemistry; Prognosis