title: Catalytic asymmetric 1,3-dipolar cycloaddition of two different ylides: facile access to chiral 1,2,4-triazinane frameworks.
abstract: Ylides at a crossing: An unprecedented 1,3-dipolar cycloaddition (cross-cycloaddition) between two different ylides was realized by using the chiral Cu(I) /tBu-Phosferrox complex as the catalyst under mild reaction conditions. This catalytic system provides an expeditious approach to the construction of highly functionalized 1,2,4-triazinane derivatives in good yields with excellent diastereoselectivities and enantioselectivities.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (China).
authors.forename: Min-Chao
authors.initials: MC
authors.lastname: Tong
authors.forename: Xuan
authors.initials: X
authors.lastname: Chen
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tao
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D008968:Molecular Conformation; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry; D014227:Triazines / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D056831:Coordination Complexes; D013882:Thiosemicarbazones; D014227:Triazines; C512188:azomethine; C093444:1,2,4-triazine; D003300:Copper
keywords: asymmetric catalysis; azomethine ylide; copper; cycloaddition; heterocycles