title: The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is an inflammatory disease associated with high risk of cardiovascular (CV) events. Recently, the rs964184 polymorphism has been associated with coronary artery disease in nonrheumatic Caucasian individuals. 2160 Spanish RA patients were genotyped for the rs964184 polymorphism. Sex, age at diagnosis and traditional CV risk factors (diabetes mellitus, dyslipidemia and smoking habit) were associated with increased risk of CV events. Interestingly, RA patients carrying the rs964184 GG genotype had significantly higher risk of CV events than those with CC genotype [hazard ratio (HR) = 2.91, 95% confidence interval (CI): 1.36-6.26, P = 0.006] after adjusting the results for sex, age at diagnosis and traditional CV risk factors. Our results indicate that rs964184 polymorphism is associated with CV disease in RA.
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: López-Mejías
authors.forename: F
authors.initials: F
authors.lastname: Genre
authors.forename: M
authors.initials: M
authors.lastname: García-Bermúdez
authors.forename: S
authors.initials: S
authors.lastname: Castañeda
authors.forename: C
authors.initials: C
authors.lastname: González-Juanatey
authors.forename: J
authors.initials: J
authors.lastname: Llorca
authors.forename: A
authors.initials: A
authors.lastname: Corrales
authors.forename: J A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.forename: J
authors.initials: J
authors.lastname: Rueda-Gotor
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Vaquero
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez-Rodríguez
authors.forename: B
authors.initials: B
authors.lastname: Fernández-Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Balsa
authors.forename: D
authors.initials: D
authors.lastname: Pascual-Salcedo
authors.forename: F J
authors.initials: FJ
authors.lastname: López-Longo
authors.forename: P
authors.initials: P
authors.lastname: Carreira
authors.forename: R
authors.initials: R
authors.lastname: Blanco
authors.forename: I
authors.initials: I
authors.lastname: González-Álvaro
authors.forename: J
authors.initials: J
authors.lastname: Martín
authors.forename: M A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000235:genetics; D002318:Cardiovascular Diseases / Q000150:complications* / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003710:Demography; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
keywords: 11q23.3; atherosclerosis; cardiovascular disease; rheumatoid arthritis; rs964184