title: Environmental sensing and regulation of gene expression in CD4+ T cell subsets.
abstract: Foxp3(+) regulatory T (Treg) cells represent a major mechanism for the maintenance of self-tolerance and immune homeostasis in various inflammatory responses. To achieve this, Foxp3(+) Treg cells must integrate a spectrum of environmental stimuli to orchestrate the required pathways for their coordinated action in vivo. Transcriptional and post-transcriptional mechanisms of gene regulation enable T cells to respond to inflammatory events, by altering the nature, amounts and activities of specific proteins produced for their controlled and coordinated modulation of immunity. Recent studies show that distinct translational programs orchestrate cellular processes in various immune cell types, including CD4(+) T cell subsets.
authors.affiliation: Department of Microbiology and Immunology, FOCIS Center of Excellence in Translational Immunology, Microbiome and Disease Tolerance Centre, McGill University and the Research Institute of the McGill University Health Centre, Montreal, QC, Canada H3G 1A4. Electronic address: Ciro.piccirillo@mcgill.ca.
authors.forename: Ciriaco A
authors.initials: CA
authors.lastname: Piccirillo
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D019070:Cell Lineage; D051858:Forkhead Transcription Factors / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000276:immunology
chemical_list: D051858:Forkhead Transcription Factors