title: [Effect of Helicteres angustifolia on rats with ulcerative colitis].
abstract: OBJECTIVE
  To investigate the effect of aqueous extract of Helicteres angustifolia (AEHA) on rats with ulcerative colitis (UC) and its mechanism.
  
  
  METHODS
  SD rats were randomly divided into 6 groups normal control group, the model group, SASP group and 21.6, 10.8, 5.4 g/kg AEHA group with 10 rats in each group. UC was induced by clyster with 2, 4,6-trinitrobenzesulphonic acid (TN-BS) in rats. Rats were given AEHA by gavage for 3 weeks, and sacrificed at day 22nd to determine the expressions of IL-10, IL-6 and TNF-alpha in blood. Colon tissue pathological changes were investigated.
  
  
  RESULTS
  Compared with the control group, the expression of IL-10 was increased, the expressions of IL-6 and TNF-alpha were decreased in AEHA treatment groups. The colon tissue damages and the symptoms of UC rats were improved.
  
  
  CONCLUSIONS
  AEHA can keep balance of inflammatory factors in blood of UC rats, and improve it's colon tissue damages and symptoms.
authors.affiliation: Zhongshan Hospital, Guangzhou University of TCM, Zhongshan 528400, China. aqiaosky@163.com
authors.forename: Yu-Qiao
authors.initials: YQ
authors.lastname: Gao
authors.forename: Dan
authors.initials: D
authors.lastname: Su
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Zhang
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Dai
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D016753:Interleukin-10 / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10