title: Emerging role of interleukin-33 in autoimmune diseases.
abstract: Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK; Department of Ophthalmology, First Affiliated Hospital of the Medical College, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Pei
authors.forename: Mark
authors.initials: M
authors.lastname: Barbour
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Fairlie-Clarke
authors.forename: Debbie
authors.initials: D
authors.lastname: Allan
authors.forename: Rong
authors.initials: R
authors.lastname: Mu
authors.forename: Hui-Rong
authors.initials: HR
authors.lastname: Jiang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*
chemical_list: C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins
keywords: ST2; autoimmune diseases; inflammation; interleukin-33