title: Pure akinesia: a kinematic analysis in a case responsive to rotigotine.
abstract: A patient with pure akinesia is described. This rare gait disorder, poorly responsive to therapy, is characterized by gait impairment which may be associated with handwriting and speech difficulties, in the absence of further signs of extrapyramidal involvement. Here, we report the improvement in a patient suffering from pure akinesia after low doses of rotigotine, a non-ergolinic dopamine agonist, detailing the kinematic analysis before and after the treatment. After therapy, an improvement in all of the gait parameters, particularly gait speed, was observed with a trend toward normalization. Our case report suggests that rotigotine may be a therapeutic option in cases of pure akinesia.
authors.forename: R
authors.initials: R
authors.lastname: Di Fabio
authors.forename: M
authors.initials: M
authors.lastname: Serrao
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
authors.forename: G
authors.initials: G
authors.lastname: Fragiotta
authors.forename: G
authors.initials: G
authors.lastname: Sandrini
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena / Q000187:drug effects; D018491:Dopamine Agonists / Q000627:therapeutic use*; D020233:Gait Disorders, Neurologic / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine