title: Ag@Fe2O3-GO nanocomposites prepared by a phase transfer method with long-term antibacterial property.
abstract: Silver has been utilized as a highly effective and broad-spectrum antibacterial agent in our daily life. However, low stability, poor long-term antibacterial efficiency, and potential environmental hazard of released Ag(+) ions may limit its practical applications. Ag-graphene oxide (GO) nanocomposites have been reported to display highly enhanced antibacterial property, yet their stability and long-term antibacterial properties have not been carefully investigated. Herein, we report the synthesis of Ag@Fe2O3-GO nanocomposites with tunable loading density up to full monolayer coverage by adopting a simple phase transfer method. Compared to Ag@Fe2O3, its GO composite shows enhanced stability with Ag(+) releasing rate decreased by more than two times under dialysis condition. We discover that the presence of GO not only slows down Ag nanoparticle oxidation process but also enables Ag(+) ions recrystallization on GO surface. The Ag@Fe2O3-GO nanocomposites have shown better and long-term antibacterial property against both Gram-negative and Gram-positive bacteria than those of plain Ag and Ag@Fe2O3, displaying great potential as a promising long-term bactericide with suppressed environmental hazard.
authors.affiliation: i-Lab and Division of Nanobiomedicine, Suzhou Key Laboratory of Nanobiomedical Characterization, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences , Suzhou, China 215123.
authors.forename: Nan
authors.initials: N
authors.lastname: Gao
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004787:Environmental Pollution; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006108:Graphite / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry; D012834:Silver / Q000737:chemistry* / Q000633:toxicity; D018030:Silver Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005290:Ferric Compounds; D010087:Oxides; D018030:Silver Compounds; D012834:Silver; D006108:Graphite