title: Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation.
authors.affiliation: The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Narihiro
authors.initials: N
authors.lastname: Toda
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Asano
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Barbas
mesh_terms: D057930:Click Chemistry; D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D008958:Models, Molecular; D010069:Oxadiazoles / Q000737:chemistry*; D010949:Plasma / Q000378:metabolism; D055550:Protein Stability; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D008301:Maleimides; D010069:Oxadiazoles; D011506:Proteins; D013438:Sulfhydryl Compounds; C043592:maleimide; D003545:Cysteine
keywords: chemoselectivity; cysteine; drug conjugates; phenyloxadiazole; protein conjugation