title: A chemodosimeter for the ratiometric detection of hydrazine based on return of ESIPT and its application in live-cell imaging.
abstract: A probe based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) has been synthesized and used for the ratiometric detection of hydrazine. The probe is designed in such a way that the excited state intramolecular proton transfer (ESIPT) of the HBT moiety gets blocked. The chemodosimetric approach of hydrazine to the probe results in the recovery of the ESIPT by removal of a free HBT moiety through subsequent substitution, cyclization, and elimination processes. The probe is successfully demonstrated to enable the detection of hydrazine in live cells.
authors.affiliation: Department of Chemistry, Bengal Engineering and Science University, Shibpur , Howrah 711103, West Bengal, India and Department of Microbiology, The University of Burdwan , Burdwan 713101, West Bengal, India.
authors.forename: Shyamaprosad
authors.initials: S
authors.lastname: Goswami
authors.forename: Sangita
authors.initials: S
authors.lastname: Das
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Aich
authors.forename: Bholanath
authors.initials: B
authors.lastname: Pakhira
authors.forename: Sukanya
authors.initials: S
authors.lastname: Panja
authors.forename: Subhra Kanti
authors.initials: SK
authors.lastname: Mukherjee
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Sarkar
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D005456:Fluorescent Dyes / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D057054:Molecular Imaging; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry; D011522:Protons; D013050:Spectrometry, Fluorescence
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D006834:Hydrazines; D010636:Phenols; D011522:Protons; C029424:hydrazine; C070846:2-(2-hydroxyphenyl)benzothiazole