title: Aphanamenes A and B, two new acyclic diterpene [4 + 2]-cycloaddition adducts from Aphanamixis grandifolia.
abstract: Aphanamenes A (1) and B (2), two unprecedented acyclic diterpene dimers formed via a [4 + 2]-cycloaddition, were isolated from the root bark of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analyses, and the absolute configuration of 1 was determined by ECD calculations. Both 1 and 2 showed significant inhibition on NO production on lipopolysaccharide-induced RAW264.7 macrophages.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Si-Ming
authors.initials: SM
authors.lastname: Shan
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D061565:Cycloaddition Reaction; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects*; D029582:Meliaceae / Q000737:chemistry; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000037:antagonists & inhibitors*; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D009589:Nitrogen Oxides; C587961:aphanamene A; C587962:aphanamene B