title: BDNF-TrkB signaling through Erk1/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids.
abstract: Activation of glucocorticoid receptors (GR) by glucocorticoid hormones (GC) enhances contextual fear memories through the activation of the Erk1/2(MAPK) signaling pathway. However, the molecular mechanism mediating this effect of GC remains unknown. Here we used complementary molecular and behavioral approaches in mice and rats and in genetically modified mice in which the GR was conditionally deleted (GR(NesCre)). We identified the tPA-BDNF-TrkB signaling pathway as the upstream molecular effectors of GR-mediated phosphorylation of Erk1/2(MAPK) responsible for the enhancement of contextual fear memory. These findings complete our knowledge of the molecular cascade through which GC enhance contextual fear memory and highlight the role of tPA-BDNF-TrkB-Erk1/2(MAPK) signaling pathways as one of the core effectors of stress-related effects of GC.
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Revest
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Le Roux
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: V
authors.initials: V
authors.lastname: Roullot-Lacarrière
authors.affiliation: 1] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France [2] INSERM U862, Neurocentre Magendie, Pathophysiology of Declarative Memory, Bordeaux, France.
authors.forename: N
authors.initials: N
authors.lastname: Kaouane
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Vallée
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Kasanetz
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Rougé-Pont
authors.affiliation: CNRS UMR7224, UPMC Université Pierre et Marie Curie, Molecular Genetics, Neurophysiology and Behavior, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Tronche
authors.affiliation: 1] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France [2] INSERM U862, Neurocentre Magendie, Pathophysiology of Declarative Memory, Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Desmedt
authors.affiliation: 1] INSERM U862, Neurocentre Magendie, Pathophysiology of Addiction, Bordeaux, France [2] Pathophysiology of Neuronal Plasticity, Université de Bordeaux, Bordeaux, France.
authors.forename: P V
authors.initials: PV
authors.lastname: Piazza
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005239:Fear / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010766:Phosphorylation; D017207:Rats, Sprague-Dawley; D020813:Receptor, trkB / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism*; D013315:Stress, Psychological / Q000503:physiopathology; D046509:Tissue Culture Techniques; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D011965:Receptors, Glucocorticoid; D020813:Receptor, trkB; D010959:Tissue Plasminogen Activator