title: Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver.
abstract: OBJECTIVE
  Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure.
  
  
  METHODS
  Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD25 or LD5 values, to Sprague-Dawley.
  
  
  RESULTS
  Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs.
  
  
  CONCLUSIONS
  These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs.
authors.affiliation: Department of Pathology, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea .
authors.forename: Jeong Kyu
authors.initials: JK
authors.lastname: Kim
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Eun
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Bae
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Shen
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Kim
authors.forename: Soha
authors.initials: S
authors.lastname: Park
authors.forename: Young Min
authors.initials: YM
authors.lastname: Ahn
authors.forename: Won Sang
authors.initials: WS
authors.lastname: Park
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Suk Woo
authors.initials: SW
authors.lastname: Nam
mesh_terms: D000818:Animals; D008099:Liver / Q000737:chemistry / Q000187:drug effects*; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D059467:Transcriptome; D055549:Volatile Organic Compounds / Q000032:analysis / Q000633:toxicity*
chemical_list: D055549:Volatile Organic Compounds