title: Comparative effect of antihypertensive therapy on blood glucose level in hypertensive patients in an Indian population.
abstract: Hypertensive patients have higher prevalence of insulin resistance and are at increased risk of developing type 2 diabetes mellitus (DM). There is scarcity of data on the relationship between antihypertensive therapies and glycaemic control in Indian population. Thus, the present study was designed to investigate such association among Indian population in a University teaching hospital.The study was carried out on 177 hypertensive patients (with new onset of diabetes or without diabetes) visiting the OPD of medicine department at Majeedia hospital, New Delhi. The drug history of hypertensive patients and blood glucose levels following 1-5 yrs of antihypertensive therapy were recorded.The gender distribution of hypertensive patients reveals a higher percentage of incidences in males (53.7%) as compared to females (46.3%). Hypertensive patient without DM on beta blockers and on thiazide shows higher incidence of impaired glucose tolerance (IGT) (17.5%, 18.5%) and DM (10%, 11%) as compared to patient receiving other antihypertensive therapy. While in patients of new onset diabetes the incidence was higher with β-blockers (56.2%) than with thiazides (31.3%) followed by calcium channel blockers (CCBs) (12.5%). There was proportionate increase in incidence with the duration of therapy (3-5 years). None of the patients who were on ACE inhibitors or on angiotensin receptor blockers (ARBs) reported any incidence of IGT or DM.To conclude, β-blockers and thiazides increases the risk of type 2 diabetes mellitus with long term antihypertensive therapy requiring regular monitoring. CCBs have lowered risks while ACE inhibitors and ARBs are relatively free of such metabolic adverse effects.
authors.affiliation: Research Scholar, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Ahmad
authors.affiliation: Consultant Physician, Majeedia Hospital, Jamia Hamdard, New Delhi, India.
authors.forename: P
authors.initials: P
authors.lastname: Kapur
authors.affiliation: Assistant Professor, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Khanam
authors.affiliation: Assistant Professor, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.affiliation: Research Scholar, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: G H
authors.initials: GH
authors.lastname: Khan
authors.affiliation: Research Scholar, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: M J
authors.initials: MJ
authors.lastname: Anwar
authors.affiliation: Associate Professor, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
authors.forename: D
authors.initials: D
authors.lastname: Vohora
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D007194:India; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001786:Blood Glucose; D002121:Calcium Channel Blockers