title: Optimization of choline administration regimen for correction of cognitive functions in rats after brain injury.
abstract: Choline diet promotes improvement of the brain cognitive functions in rats with moderate-to-severe traumatic brain injury. In previous studies, the rats received choline being standard (0.2%) or choline-supplemented (2%) diet for 2 weeks prior to and 2 weeks after experimental brain injury. To the end of the experiments (in 4 weeks), the post-traumatic disturbances in the cognitive functions were observed in both groups, although they were less pronounced than in the rats kept on the choline-supplemented diet. Based on original mathematical model, this paper proposes a method to calculate the most efficient use of choline to correct the brain cognitive functions. In addition to evaluating the cognitive functions, the study assessed expression of α7 nicotinic acetylcholine receptors, the amount of consumed food and water, and the dynamics of body weight.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University; Laboratory in Self-Developing Systems, V. A. Trapeznikov Institute of Control Sciences, Russian Academy of Sciences, Moscow, Russia. gusvbr@mail.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Guseva
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskii
authors.forename: V B
authors.initials: VB
authors.lastname: Gusev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism; D002794:Choline / Q000378:metabolism / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D004032:Diet; D019587:Dietary Supplements; D018696:Neuroprotective Agents / Q000378:metabolism / Q000627:therapeutic use*; D051381:Rats; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000819:agonists / Q000187:drug effects* / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D064569:alpha7 Nicotinic Acetylcholine Receptor; D002794:Choline