title: Focus on molecular events in the anterior chamber leading to glaucoma.
abstract: Primary open-angle glaucoma is a multifactorial disease that affects the retinal ganglion cells, but currently its therapy is to lower the eye pressure. This indicates a definite involvement of the trabecular meshwork, key region in the pathogenesis of glaucoma. This is the first target of glaucoma, and its functional complexity is a real challenge to search. Its functions are those to allow the outflow of aqueous humor and not the reflux. This article describes the morphological and functional changes that happen in anterior chamber. The "primus movens" is oxidative stress that affects trabecular meshwork, particularly its endothelial cells. In these develops a real mitochondriopaty. This leads to functional impotence, the trabecular meshwork altering both motility and cytoarchitecture. Its cells die by apoptosis, losing barrier functions and altering the aqueous humor outflow. All the morphological alterations occur that can be observed under a microscope. Intraocular pressure rises and the malfunctioning trabecular meshwork endotelial cells express proteins that completely alter the aqueous humor. This is a liquid whose functional proteomics complies with the conditions of the trabecular meshwork. Indeed, in glaucoma, it is possible detect the presence of proteins which testify to what occurs in the anterior chamber. There are six classes of proteins which confirm the vascular endothelium nature of the anterior chamber and are the result of the morphofunctional trabecular meshwork decay. It is possible that, all or in part, these proteins can be used as a signal to the posterior pole.
authors.affiliation: Ophthalmology Unit, Department of Head and Neck Pathologies, St Martino Hospital, Viale Benedetto XV, 16132, Genoa, Italy, sergio.sacca@hsanmartino.it.
authors.forename: Sergio Claudio
authors.initials: SC
authors.lastname: Saccà
authors.forename: Alberto
authors.initials: A
authors.lastname: Izzotti
mesh_terms: D000867:Anterior Chamber / Q000378:metabolism* / Q000473:pathology*; D000975:Antioxidants / Q000378:metabolism; D004249:DNA Damage; D005901:Glaucoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species