title: Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis.
abstract: The aim of the study was to evaluate apoptosis through regulation of Bcl-2, Bax and Mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. This is a cross-sectional study of 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma, who underwent laparoscopy. Bcl-2 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly reduced in the cystic endometriotic lesions (p < 0.0001). There was a significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells (p < 0.0001). Bax expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the endometrium (p < 0.0001). There was a significant difference in Bax expression between cystic endometriotic stromal cells and endometrial stromal cells (p = 0.03). Mcl-1 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the cystic endometriotic lesions (p = 0.003). Apoptosis may play a role in the pathophysiology of endometriosis by potentially contributing to the survival of regurgitating endometrial cells in the peritoneal cavity.
authors.affiliation: Department of Obstetrics and Gynaecology, Medicana Bahcelievler Hospital.
authors.forename: D
authors.initials: D
authors.lastname: Korkmaz
authors.forename: E
authors.initials: E
authors.lastname: Bastu
authors.forename: O
authors.initials: O
authors.lastname: Dural
authors.forename: C
authors.initials: C
authors.lastname: Yasa
authors.forename: E
authors.initials: E
authors.lastname: Yavuz
authors.forename: F
authors.initials: F
authors.lastname: Buyru
mesh_terms: D000328:Adult; D017209:Apoptosis; D003430:Cross-Sectional Studies; D003560:Cysts / Q000378:metabolism; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D064549:Myeloid Cell Leukemia Sequence 1 Protein / Q000378:metabolism*; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: C579095:MCL1 protein, human; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D051028:bcl-2-Associated X Protein