title: Flattening-filter-free intensity modulated breath-hold image-guided SABR (Stereotactic ABlative Radiotherapy) can be applied in a 15-min treatment slot.
abstract: Hypofractionated image-guided stereotactic ablative radiotherapy (igSABR) is effective in small lung/liver lesions. Computer-assisted breath-hold reduces intrafraction motion but, as every gating/triggering strategy, reduces the duty cycle, resulting in long fraction times if combined with intensity-modulated radiotherapy (IMRT). 10 MV flattening-filter-free IMRT reduces daily fraction duration to <10 min for single doses of 5-20 Gy.
authors.affiliation: Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Germany. Electronic address: judit.boda-heggemann@umm.de.
authors.forename: Judit
authors.initials: J
authors.lastname: Boda-Heggemann
authors.forename: Sabine
authors.initials: S
authors.lastname: Mai
authors.forename: Jens
authors.initials: J
authors.lastname: Fleckenstein
authors.forename: Kerstin
authors.initials: K
authors.lastname: Siebenlist
authors.forename: Anna
authors.initials: A
authors.lastname: Simeonova
authors.forename: Michael
authors.initials: M
authors.lastname: Ehmann
authors.forename: Volker
authors.initials: V
authors.lastname: Steil
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
authors.forename: Frank
authors.initials: F
authors.lastname: Lohr
authors.forename: Florian
authors.initials: F
authors.lastname: Stieler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D062485:Breath Holding; D015331:Cohort Studies; D019583:Dose Fractionation, Radiation; D005374:Filtration; D006801:Humans; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D061089:Radiotherapy, Image-Guided; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D012189:Retrospective Studies
keywords: Breath hold; FFF; Image guidance; Lung; SABR