title: Poly(ethylene glycol)-poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications.
abstract: Stimuli triggered polymers provide a variety of applications related with the biomedical fields. Among various stimuli triggered mechanisms, thermoresponsive mechanisms have been extensively investigated, as they are relatively more convenient and effective stimuli for biomedical applications. In a contemporary approach for achieving the sustained action of proteins, peptides and bioactives, injectable depots and implants have always remained the thrust areas of research. In the same series, Poloxamer based thermogelling copolymers have their own limitations regarding biodegradability. Thus, there is a need to have an alternative biomaterial for the formulation of injectable hydrogel, which must remain biocompatible along with safety and efficacy. In the same context, poly(ethylene glycol) (PEG) based copolymers play a crucial role as a biomedical material for biomedical applications, because of their biocompatibility, biodegradability, thermosensitivity and easy controlled characters. This review stresses on the physicochemical property, stability and composition prospects of smart PEG/poly(lactic-co-glycolic acid) (PLGA) based thermoresponsive injectable hydrogels, recently utilized for biomedical applications. The manuscript also highlights the synthesis scheme and stability characteristics of these copolymers, which will surely help the researchers working in the same area. We have also emphasized the applied use of these smart copolymers along with their formulation problems, which could help in understanding the possible modifications related with these, to overcome their inherent associated limitations.
authors.affiliation: University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G. 492010, India. Electronic address: itsmeamitalex@gmail.com.
authors.forename: Amit
authors.initials: A
authors.lastname: Alexander
authors.lastname: Ajazuddin
authors.forename: Junaid
authors.initials: J
authors.lastname: Khan
authors.forename: Swarnlata
authors.initials: S
authors.lastname: Saraf
authors.forename: Shailendra
authors.initials: S
authors.lastname: Saraf
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007267:Injections; D007773:Lactates / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; D007773:Lactates; D004364:Pharmaceutical Preparations; C088513:poly(lactic acid-ethylene glycol); D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols
keywords: Hydrogel; In Situ; Parenteral; Polyethylene glycol; Thermoresponsive; Thermoreversible