title: In silico prediction of the cell proliferation in porous scaffold using model of effective pore.
abstract: The mathematical prediction of cell proliferation in porous scaffold still remains a challenge. The analysis of existing models and experimental data confirms a need for a new solution, which takes into account cells" development on the scaffold pore walls as well as some additional parameters such as the pore size, cell density in cellular layers, the thickness of the growing cell layer and others. The simulations, presented below, are based on three main approaches. The first approach takes into account multilayer cell growth on the pore walls of the scaffold. The second approach is a simulation of cell proliferation in a discrete process as a continuous one. The third one is the representation of scaffold structure as a system of cylindrical channels. Oxygen (nutrient) mass transfer is realized inside these channels. The model, described below, proposes the new solution to time dependent description of cell proliferation in porous scaffold and optimized trophical conditions for tissue development.
authors.affiliation: BioDevice Systems, Praha 10, Vršovice, Bulharská 996/20, Czech Republic. Electronic address: biodevicesystems@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Makhaniok
authors.forename: Y
authors.initials: Y
authors.lastname: Haranava
authors.forename: V
authors.initials: V
authors.lastname: Goranov
authors.forename: S
authors.initials: S
authors.lastname: Panseri
authors.forename: S
authors.initials: S
authors.lastname: Semerikhina
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Marcacci
authors.forename: V
authors.initials: V
authors.lastname: Dediu
mesh_terms: D002452:Cell Count; D049109:Cell Proliferation; D003198:Computer Simulation; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D016062:Porosity; D049490:Systems Biology; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D010100:Oxygen
keywords: Cell density; Cell proliferation; Diffusion; Mathematical modeling; Oxygen uptake rate; Porous scaffold