title: 1-(1,3-Benzodioxol-5-yl-carbo-nyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice.
abstract: The current study was designed to investigate the effects of 1-(1,3-benzodioxol-5-yl-carbonyl) piperidine (1-BCP) on swimming endurance capacity which as one indicator of fatigue in the weight-loaded forced swimming mice. Mice were given either vehicle or 1-BCP (0.1, or 0.2 mmol/kg body weight daily) by intraperitoneal injection once daily for 2 weeks. The 1-BCP groups showed a significant increase in swimming time to exhaustion compared with the control group. 1-BCP increased the liver glycogen (LG) and muscle glycogen (MG) contents significantly, while decreased the lactic acid (LA) and blood urea nitrogen (BUN) levels notably compared with control group. Besides, 1-BCP treatment also significantly improved the endogenous cellular antioxidant enzymes in mice by increasing the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Therefore, this study demonstrated for the first time that the supplementation of 1-BCP, as a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, could enhance the endurance capacity of mice and facilitated them recovery from fatigue. Thus, we provide a new effective therapeutic strategy for fatigue.
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Science, Northwestern Polytechnical University.
authors.forename: Wutu
authors.initials: W
authors.lastname: Fan
authors.forename: Xianglong
authors.initials: X
authors.lastname: Wu
authors.forename: Yalei
authors.initials: Y
authors.lastname: Pan
authors.forename: Chenrui
authors.initials: C
authors.lastname: Li
authors.forename: Yinbo
authors.initials: Y
authors.lastname: Niu
authors.forename: Yuankun
authors.initials: Y
authors.lastname: Zhai
authors.forename: Qibing
authors.initials: Q
authors.lastname: Mei
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D005221:Fatigue / Q000188:drug therapy* / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000378:metabolism; D010807:Physical Endurance; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D018091:Receptors, AMPA / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D013550:Swimming; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D004149:Dioxoles; D010880:Piperidines; D018091:Receptors, AMPA; D019344:Lactic Acid; C085415:1-(1,3-benzodioxol-5-ylcarbonyl)piperidine; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D006003:Glycogen; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase