title: Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos.
abstract: Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultaneous delivery of folic acid or vitamin B9 , and hinokitiol, a relevant natural bioactive compound that exhibits anticancer activity against human malignant melanoma cells, from these multidirectionally self-assembled unimolecular nanocarriers is illustrated.
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU) - Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018, San Sebastián, Spain; Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, 20800, San Sebastián, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Sanchez-Sanchez
authors.forename: Somayeh
authors.initials: S
authors.lastname: Akbari
authors.forename: Angel J
authors.initials: AJ
authors.lastname: Moreno
authors.forename: Federica Lo
authors.initials: FL
authors.lastname: Verso
authors.forename: Arantxa
authors.initials: A
authors.lastname: Arbe
authors.forename: Juan
authors.initials: J
authors.lastname: Colmenero
authors.forename: José A
authors.initials: JA
authors.lastname: Pomposo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D005492:Folic Acid / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000138:chemical synthesis / Q000737:chemistry*; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D056004:Molecular Dynamics Simulation; D018716:Molecular Mimicry; D039821:Monoterpenes / Q000008:administration & dosage; D053758:Nanoparticles / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology; D012867:Skin / Q000187:drug effects; D014334:Tropolone / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D064267:Intrinsically Disordered Proteins; D039821:Monoterpenes; D020011:Protective Agents; D014334:Tropolone; D005492:Folic Acid; C009479:beta-thujaplicin
keywords: drug delivery; nanocarriers; nanomedicine; nanoparticles; self-assembly