title: Lipid profile and atherogenic indices soon after birth in Japanese preterm infants.
abstract: OBJECTIVE
  The intra-uterine environment affects the risk of development of cardiovascular disease in adulthood. The aim of this study was to determine the influence of prematurity and foetal growth restriction on lipid metabolism, by assessing atherogenic indices soon after birth in preterm infants.
  
  
  METHODS
  Blood samples were collected within 20 min of birth from 80 preterm infants with a gestational age of ≤35 weeks. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), apolipoprotein-A1 (apoA1) and apolipoprotein-B (apoB) levels were measured. The ratio of TC/HDLc, LDLc/HDLc and apoB/apoA1 were also calculated. Correlations between these indices and gestational age, birth weight and the standard deviation (SD) score for birth weight were also determined.
  
  
  RESULTS
  Gestational age, birth weight and SD score for birth weight were negatively correlated with the TC/HDLc, LDLc/HDLc and apoB/apoA1 ratios.
  
  
  CONCLUSIONS
  In preterm infants, prematurity and poor foetal growth may influence lipid and apolipoprotein metabolism and affect atherogenic indices at birth.
authors.affiliation: Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Shoji
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Murano
authors.forename: Mari
authors.initials: M
authors.lastname: Mori
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ohkawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Suganuma
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeno
authors.forename: Ken
authors.initials: K
authors.lastname: Hisata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirayama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ueno
authors.forename: Takashi
authors.initials: T
authors.lastname: Miida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D050356:Lipid Metabolism; D008297:Male; D010865:Pilot Projects
chemical_list: D001053:Apolipoproteins
keywords: Apolipoproteins; Foetal growth restriction; Lipoproteins; Preterm infants