title: Hepatocellular adenomatosis: what should the term stand for!
abstract: In 1985, adenomatosis, a term coined to mean ten or more nodules, was considered as a specific entity different from hepatocellular adenoma (HCA) whether single or multiple. In the 2000s the term has lost its individuality. The great contribution of the classification was to clearly demonstrate that in all hepatocellular subtypes and in particular etiologies such as glycogenosis and male hormone administration, HCA could be solitary, multiple (<10) or multiple (>10: adenomatosis). Management of hepatocellular adenomatosis may not be different from solitary or multiple HCA. To keep its specificity in terms of management and prognosis compared to solitary or multiple HCA, it is necessary to indicate the number of nodules including the combination of three parameters: size, location and subtypes. When the classical armentarium to treat nodules is not possible or too risky, embolization or liver transplantation remains the only therapeutic options.
authors.affiliation: Service de Radiologie, Hôpital Saint-André, CHU de Bordeaux, 33075 Bordeaux, France. Electronic address: Nora.frulio@chu-bordeaux.fr.
authors.forename: Nora
authors.initials: N
authors.lastname: Frulio
authors.affiliation: Service de Chirurgie Hépatobiliaire et Pancréatique, Maison du Haut-Lévèque, CHU de Bordeaux, 33604 Pessac, France. Electronic address: Laurence.chiche@chu-bordeaux.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Service de Pathologie, Hôpital Pellegrin, CHU de Bordeaux, 33075 Bordeaux, France; Inserm U1053, Université Victor-Segalen, 33076 Bordeaux, France. Electronic address: paulette.bioulac-sage@chu-bordeaux.fr.
authors.forename: Paulette
authors.initials: P
authors.lastname: Bioulac-Sage
authors.affiliation: Inserm U1053, Université Victor-Segalen, 33076 Bordeaux, France. Electronic address: charles.balabaud@u-bordeaux2.fr.
authors.forename: Charles
authors.initials: C
authors.lastname: Balabaud
mesh_terms: D018248:Adenoma, Liver Cell / Q000209:etiology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D004621:Embolization, Therapeutic; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology*; D016031:Liver Transplantation; D009154:Mutation; D009626:Terminology as Topic; D051176:beta Catenin / Q000235:genetics
chemical_list: D003278:Contraceptives, Oral, Hormonal; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D051176:beta Catenin