title: Splenic infarction in a child with primary Epstein-Barr virus infection.
abstract: Described herein is the case of a previously healthy 7-year-old girl who had splenic infarction. This lesion was identified 1 day after the first presentation of peri-umbilical and right upper quadrant pain. She had abnormal hepatic function and mild splenomegaly, and was diagnosed as having primary Epstein-Barr virus (EBV) infection. Coagulation profiles indicated low plasma activity of protein C (49%) and protein S (47%), which normalized 3 weeks later. Hypercoagulability in transient protein C and protein S deficiency might contribute to the development of splenic infarction in infectious mononucleosis.
authors.affiliation: Department of Pediatrics, School of Medicine, Chungnam National University, Daejeon, Korea.
authors.forename: Mi Hyeon
authors.initials: MH
authors.lastname: Gang
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Kim
mesh_terms: D001777:Blood Coagulation; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000821:virology; D013159:Splenic Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D019851:Thrombophilia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
keywords: Epstein-Barr virus infection; protein C and protein S; splenic infarction