title: Voice quality after treatment of T1a glottic cancer.
abstract: OBJECTIVE
  To compare voice handicap and quality of life after radiotherapy (RT) versus transoral laser surgery (LS) for T1a glottic carcinoma.
  
  
  METHODS
  Retrospective study (1996-2011) of patients treated with RT or LS for T1a glottic squamous cell carcinoma with curative intent.
  
  
  METHODS
  Disease-free patients were assessed using Voice Handicap Index (VHI 30) and European Organization for Research and Treatment of Cancer Head and Neck Quality of Life (EORTC QLQ-HN35) questionnaires.
  
  
  RESULTS
  Of 147 patients, 95 (65%) completed the questionnaires: fifty-one patients an average of 8 years after RT and 44 patients an average of 4 years after LS (no difference in age or sex ratio). The average total VHI 30 was 13.1 for RT and 29.2 for LS (P < .0001), with average emotional, physical and functional subscores significantly different. The average total EORTC QLQ-HN35 was 37.7 for RT versus 40.7 for LS (P = .7), with a difference only in the speaking subscore (P = .04).
  
  
  CONCLUSIONS
  Long-term subjective voice-related quality of life was worse after LS, with no difference in other domains. These results should be interpreted in light of the biases inherent in retrospective studies.
  
  
  METHODS
  4.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
authors.forename: Samia
authors.initials: S
authors.lastname: Laoufi
authors.forename: Haïtham
authors.initials: H
authors.lastname: Mirghani
authors.forename: François
authors.initials: F
authors.lastname: Janot
authors.forename: Dana M
authors.initials: DM
authors.lastname: Hartl
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D053685:Laser Therapy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D020266:Radiotherapy, Conformal / Q000009:adverse effects* / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014832:Voice Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D014833:Voice Quality
keywords: Glottic cancer; laser; quality of life; radiotherapy; squamous cell carcinoma; voice handicap