title: Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers: a systematic review.
abstract: BACKGROUND
  Nonhealing ulcers affect patient quality of life and impose a substantial financial burden on the health care system.
  
  
  OBJECTIVE
  To systematically evaluate benefits and harms of advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers.
  
  
  METHODS
  MEDLINE (1995 to June 2013), the Cochrane Library, and reference lists.
  
  
  METHODS
  English-language randomized trials reporting ulcer healing or time to complete healing in adults with nonhealing ulcers treated with advanced therapies.
  
  
  METHODS
  Study characteristics, outcomes, adverse events, study quality, and strength of evidence were extracted by trained researchers and confirmed by the principal investigator.
  
  
  RESULTS
  For diabetic ulcers, 35 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with a biological skin equivalent (relative risk [RR], 1.58 [95% CI, 1.20 to 2.08]) and negative pressure wound therapy (RR, 1.49 [CI, 1.11 to 2.01]) compared with standard care and low-strength evidence for platelet-derived growth factors and silver cream compared with standard care. For venous ulcers, 20 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with keratinocyte therapy (RR, 1.57 [CI, 1.16 to 2.11]) compared with standard care and low-strength evidence for biological dressing and a biological skin equivalent compared with standard care. One small trial of arterial ulcers reported improved healing with a biological skin equivalent compared with standard care. Overall, strength of evidence was low for ulcer healing and low or insufficient for time to complete healing.
  
  
  CONCLUSIONS
  Only studies of products approved by the U.S. Food and Drug Administration were reviewed. Studies were predominantly of fair or poor quality. Few trials compared 2 advanced therapies.
  
  
  CONCLUSIONS
  Compared with standard care, some advanced wound care therapies may improve the proportion of ulcers healed and reduce time to healing, although evidence is limited.
  
  
  BACKGROUND
  Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Quality Enhancement Research Initiative.
authors.forename: Nancy
authors.initials: N
authors.lastname: Greer
authors.forename: Neal A
authors.initials: NA
authors.lastname: Foman
authors.forename: Roderick
authors.initials: R
authors.lastname: MacDonald
authors.forename: James
authors.initials: J
authors.lastname: Dorrian
authors.forename: Patrick
authors.initials: P
authors.lastname: Fitzgerald
authors.forename: Indulis
authors.initials: I
authors.lastname: Rutks
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Wilt
mesh_terms: D001158:Arteries; D057186:Comparative Effectiveness Research; D048909:Diabetes Complications; D006801:Humans; D007866:Leg / Q000098:blood supply*; D007871:Leg Ulcer / Q000628:therapy*; D012307:Risk Factors; D014647:Varicose Ulcer / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing