title: Hyperglycaemia increases S100β after short experimental cardiac arrest.
abstract: BACKGROUND
  Hyperglycaemia is associated with aggravated ischaemic brain injury. The main objective of this study was to investigate the effects on cerebral perfusion of 5 min of cardiac arrest during hyperglycaemia and normoglycaemia.
  
  
  METHODS
  Twenty triple-breed pigs (weight: 22-29 kg) were randomised and clamped at blood glucose levels of 8.5-10 mM [high (H)] or 4-5.5 mM [normal (N)] and thereafter subjected to alternating current-induced 5 min-cardiac arrest followed by 8 min of cardiopulmonary resuscitation and direct current shock to restore spontaneous circulation.
  
  
  RESULTS
  Haemodynamics, laser Doppler measurements and regional venous oxygen saturation (HbO2) were monitored, and biochemical markers in blood [S100β, interleukin (IL)-6 and tumour necrosis factor (TNF)] quantified throughout an observation period of 3 h. The haemodynamics and physiological measurements were similar in the two groups. S100β increased over the experiment in the H compared with the N group (P < 0.05). IL-6 and TNF levels increased across the experiment, but no differences were seen between the groups.
  
  
  CONCLUSIONS
  The enhanced S100β response is compatible with increased cerebral injury by hyperglycaemic compared with normoglycaemic 5 min of cardiac arrest and resuscitation. The inflammatory cytokines were similar between groups.
authors.affiliation: Department of Surgical Sciences, Section of Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Molnar
authors.forename: M
authors.initials: M
authors.lastname: Bergquist
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: L
authors.initials: L
authors.lastname: Wiklund
authors.forename: F
authors.initials: F
authors.lastname: Lennmyr
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000502:physiology; D006328:Cardiac Catheterization; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology; D006323:Heart Arrest / Q000097:blood*; D006439:Hemodynamics / Q000502:physiology; D006943:Hyperglycemia / Q000097:blood*; D015850:Interleukin-6 / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D013552:Swine; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D015850:Interleukin-6; D064568:S100 Calcium Binding Protein beta Subunit; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen