title: Dominantly Inherited Alzheimer Network: facilitating research and clinical trials.
abstract: The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer's disease (AD). Its primary aims are to investigate the temporal ordering of AD pathophysiological changes that occur in asymptomatic mutation carriers and to identify those markers that herald the transition from cognitive normality to symptomatic AD. DIAN participants undergo longitudinal evaluations, including clinical and cognitive assessments and measurements of molecular and imaging AD biomarkers. This review details the unique attributes of DIAN as a model AD biomarker study and how it provides the infrastructure for innovative research projects, including clinical trials. The recent design and launch of the first anti-amyloid-beta secondary prevention trial in AD, led by the related DIAN Trials Unit, also are discussed.
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: Krista L
authors.initials: KL
authors.lastname: Moulder
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: B Joy
authors.initials: BJ
authors.lastname: Snider
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mills
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: Virginia D
authors.initials: VD
authors.lastname: Buckles
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Santacruz
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Bateman
authors.affiliation: Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St. Louis, MO 63108, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris