title: Frequent truncating mutations of STAG2 in bladder cancer.
abstract: Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
authors.affiliation: 1] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA. [2] Department of Pathology, University of California, San Francisco, San Francisco, California, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Solomon
authors.forename: Jung-Sik
authors.initials: JS
authors.lastname: Kim
authors.forename: Jolanta
authors.initials: J
authors.lastname: Bondaruk
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
authors.forename: Zeng-Feng
authors.initials: ZF
authors.lastname: Wang
authors.forename: Abdel G
authors.initials: AG
authors.lastname: Elkahloun
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ozawa
authors.forename: Julia
authors.initials: J
authors.lastname: Gerard
authors.forename: Dazhong
authors.initials: D
authors.lastname: Zhuang
authors.forename: Shizhen
authors.initials: S
authors.lastname: Zhang
authors.forename: Neema
authors.initials: N
authors.lastname: Navai
authors.forename: Arlene
authors.initials: A
authors.lastname: Siefker-Radtke
authors.forename: Joanna J
authors.initials: JJ
authors.lastname: Phillips
authors.forename: Brian D
authors.initials: BD
authors.lastname: Robinson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rubin
authors.forename: Björn
authors.initials: B
authors.lastname: Volkmer
authors.forename: Richard
authors.initials: R
authors.lastname: Hautmann
authors.forename: Rainer
authors.initials: R
authors.lastname: Küfer
authors.forename: Pancras C W
authors.initials: PC
authors.lastname: Hogendoorn
authors.forename: George
authors.initials: G
authors.lastname: Netto
authors.forename: Dan
authors.initials: D
authors.lastname: Theodorescu
authors.forename: C David
authors.initials: CD
authors.lastname: James
authors.forename: Bogdan
authors.initials: B
authors.lastname: Czerniak
authors.forename: Markku
authors.initials: M
authors.lastname: Miettinen
authors.forename: Todd
authors.initials: T
authors.lastname: Waldman
mesh_terms: D000818:Animals; D034961:Antigens, Nuclear / Q000235:genetics*; D018797:Cell Cycle Proteins; D045744:Cell Line, Tumor; D018389:Codon, Nonsense; D005260:Female; D005787:Gene Frequency; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology; D019459:Urothelium / Q000473:pathology; D000097722:Cohesins
chemical_list: D034961:Antigens, Nuclear; D018797:Cell Cycle Proteins; D018389:Codon, Nonsense; C508565:STAG2 protein, human; D000097722:Cohesins