title: Epidemiological study for personal risk factors and quality of life related to Dupuytren's disease in a mountain village of Japan.
abstract: BACKGROUND
  This study investigated the etiology, personal risk factors, and quality of life related to Dupuytren's disease among residents of a mountain village in Japan.
  
  
  METHODS
  Medical examinations were conducted of 401 adult residents (163 men, 238 women; average age of 66.7 years, range 40-92) of a mountain village in Japan. All had completed a self-administered questionnaire including items for gender, weight, height, dominant hand, occupation, history of diabetes mellitus, and frequency of smoking tobacco and drinking alcohol, in addition to EuroQol-5-Dimensions-3-level Japanese version. Blood samples were collected and assessed for biochemical markers related to Dupuytren's disease. The Dupuytren's disease diagnosis was based on clinical signs. Meyerding's classification was used to ascertain the disease severity. After examining background data and physical examination data related to Dupuytren's disease, we evaluated the association of Dupuytren's disease with those factors using univariate and logistic regression analysis.
  
  
  RESULTS
  Dupuytren's disease was diagnosed in 28 subjects (7.0%). Univariate analysis revealed associations of age, male gender, occupation, history of diabetes mellitus, and alcohol intake with Dupuytren's disease. Logistic regression analysis after adjustment for age revealed a significant association between Dupuytren's disease and male gender, occupation, and history of alcohol intake. No significant difference was found between Dupuytren's disease patients and participants without this disease in the scoring and visual analog scale of EuroQol. No relation was found in scoring, the visual analog scale of EuroQol, or grading of Meyerding's classification in participants with Dupuytren's disease.
  
  
  CONCLUSIONS
  This cross-sectional study revealed Dupuytren's disease in 7.0% of 401 subjects among the general population of a mountain village in Japan. The prevalence is higher with age and is apparently associated with male gender, occupation and alcohol intake. Risk factors associated with Dupuytren's disease were identified as age, male gender, occupation, and alcohol consumption habits.
authors.affiliation: Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan, tajikatsuyoshi@yahoo.co.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tajika
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kaneko
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsunoda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Takahito
authors.initials: T
authors.lastname: Sutou
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Takagishi
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004782:Environmental Health; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D011788:Quality of Life; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012424:Rural Population; D017678:Sex Distribution; D012737:Sex Factors