title: Chemical composition and biological activities of the essential oil of Athanasia brownii Hochr. (Asteraceae) endemic to Madagascar.
abstract: The essential oil obtained from hydrodistillation of flowering aerial parts of Athanasia brownii (Asteraceae) was studied for its chemical composition by GC/FID and GC/MS, and for biological activity, namely, antioxidant, antimicrobial, and chemopreventive potential, by DPPH (=2,2-diphenyl-1-picrylhydrazyl), ABTS (=2,2'-azinobis[3-ethylbenzothioline-6-sulfonic acid), and FRAP (=ferric reducing antioxidant power), disk diffusion test, and MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, respectively. The oil was characterized by a high content of oxygenated sesquiterpenes (71.2%), with selin-11-en-4α-ol (24.6%), caryophyllene oxide (8.7%), humulene epoxide II (5.1%), and (E)-nerolidol (4.9%) as the predominant compounds. The oil showed a moderate activity against streptococci as well as radical-scavenging potential, while the inhibitory effects against human cancer cells examined such as A375 (malignant melanoma) and HCT 116 (colon carcinoma) were significant, with IC50 values of 19.85 and 29.53 μg/ml, respectively.
authors.affiliation: Département de Génie Chimique, Ecole Supérieure Polytechnique, Université d'Antananarivo, Antananarivo, Madagascar; Institut Malgache de Recherches Appliquées, Antananarivo, Madagascar.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rasoanaivo
authors.forename: Richard
authors.initials: R
authors.lastname: Fortuné Randriana
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
authors.forename: Marcello
authors.initials: M
authors.lastname: Nicoletti
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Dezemona
authors.initials: D
authors.lastname: Petrelli
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vitali
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.forename: Sauro
authors.initials: S
authors.lastname: Vittori
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006094:Gram-Positive Bacteria / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D008270:Madagascar; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D009822:Oils, Volatile
keywords: Athanasia brownii; Biological activity; Essential oils