title: Nutrient-sensing pathways and metabolic regulation in stem cells.
abstract: Stem cells exert precise regulation to maintain a balance of self-renewal and differentiation programs to sustain tissue homeostasis throughout the life of an organism. Recent evidence suggests that this regulation is modulated, in part, via metabolic changes and modifications of nutrient-sensing pathways such as mTOR and AMPK. It is becoming increasingly clear that stem cells inhibit oxidative phosphorylation in favor of aerobic glycolysis for energy production. Recent progress has detailed the molecular mechanisms of this metabolic phenotype and has offered insight into new metabolic pathways that may be involved in stem cell homeostasis.
authors.affiliation: Abramson Family Cancer Research Institute, 2 Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Ochocki
authors.forename: M Celeste
authors.initials: MC
authors.lastname: Simon
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004734:Energy Metabolism; D006019:Glycolysis; D006706:Homeostasis; D006801:Humans; D010085:Oxidative Phosphorylation; D015398:Signal Transduction; D055153:Stem Cell Niche; D013234:Stem Cells / Q000378:metabolism*