title: [Combined inflating lung and insufflating calf pulmonary surfactant under general anesthesia in the treatment of postoperative intractable atelectasis].
abstract: OBJECTIVE
  To explore the efficacy and safety of combined inflating lung and insufflating calf pulmonary surfactant under general anesthesia for treating postoperative intractable atelectasis.
  
  
  METHODS
  From August 2006 to January 2013, 15 patients with obstinate postoperative atelectasis receiving pressure control lung expansion were enrolled. The bronchial cannula was intubated into the affected side to assist the expanding of the lung, and the calf pulmonary surfactant was insufflated selectively. The chest auscultation and computed tomography (CT) scan was performed at 1 d and 5 d after the procedure respectively, to evaluation the effect. The airway pressure, mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR) and oxygen saturation (SpO2) were recorded before the treatment, during the treatment and after the treatment.Monitoring arterial blood gas before and after treatment.
  
  
  RESULTS
  After the expansion of the lung and insufflation of calf pulmonary surfactants, the iconographic scan showed that collapsed alveolar was reinflated in 12 (80.0%) patients at 1 d after the treatment and in 14 patients(93.3%) at 5 d after the procedure.There were not notable vital sign change and complications during the treatment.At after the treatment, 1, 3, 5 and 7 d after the treatment, PaO2 was higher (P < 0.05), and there were not significantly difference in the PaCO2 and pH (P > 0.05) .
  
  
  CONCLUSIONS
  Combined pressure control lung expansion with selectively insufflating calf pulmonary surfactant under general anesthesia may be an effective therapy for postoperative intractable atelectasis.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Jiaxing Medical College, Jiaxing 314000, China.
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Lu
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Gu-ping
authors.initials: GP
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Yao
authors.forename: Bing
authors.initials: B
authors.lastname: Huang
authors.forename: Xu-yan
authors.initials: XY
authors.lastname: Zhou
authors.forename: Jian-liang
authors.initials: JL
authors.lastname: Sun
authors.forename: Jian-long
authors.initials: JL
authors.lastname: DU
authors.forename: Guo-hao
authors.initials: GH
authors.lastname: Xie
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000818:Animals; D002417:Cattle; D005260:Female; D006801:Humans; D007327:Insufflation; D008297:Male; D008875:Middle Aged; D001261:Pulmonary Atelectasis / Q000628:therapy*; D011663:Pulmonary Surfactants / Q000009:adverse effects* / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D011663:Pulmonary Surfactants