title: An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma.
abstract: OBJECTIVE
  To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma.
  
  
  METHODS
  A retrospective outcome analysis study was performed using data from a tertiary referral centre.
  
  
  RESULTS
  Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (p = 0.502). There was no significant association between laryngeal preservation rates and age (p = 0.779), anterior commissure involvement (p = 0.081), tumour stage (1a or 1b) (p = 0.266) or treatment modality (surgery or radiotherapy; p = 0.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy vs 10.0 per cent for surgery; p = 0.220). The overall 5-year regional recurrence rate was 1.2 per cent.
  
  
  CONCLUSIONS
  Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes.
authors.affiliation: Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Aydil
authors.forename: M
authors.initials: M
authors.lastname: Akmansu
authors.forename: Y
authors.initials: Y
authors.lastname: Kizil
authors.forename: O
authors.initials: O
authors.lastname: Yazici
authors.forename: S
authors.initials: S
authors.lastname: Ustün
authors.forename: F
authors.initials: F
authors.lastname: Karaloğlu
authors.forename: A
authors.initials: A
authors.lastname: Köybaşioğlu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005931:Glottis; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy / Q000401:mortality; D053685:Laser Therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome