title: Epsilon-aminocaproic acid improves postrecirculation hemodynamics by reducing intraliver activated protein C consumption in orthotopic liver transplantation.
abstract: BACKGROUND
  Activated protein C (APC) is related to regulating the inflammatory response and hemodynamic stability upon reperfusion in cardiac operations and orthotopic liver transplantation (OLT). Epsilon-aminocaproic acid (EACA) is frequently used to treat fibrinolysis during OLT. It also has inhibitory effects related to the inflammatory response. However, it remains to be determined whether EACA can attenuate intraliver APC consumption and improve hemodynamic stability after reperfusion during OLT.
  
  
  METHODS
  Fifty-nine recipients were randomized to receive either EACA (150 mg kg(-1) given intravenously prior to incision, followed by 15 mg kg(-1) h(-1) infusion until 2 h after the graft reperfusion) or the same volume of saline. Blood samples to assess plasma APC and protein C were obtained immediately before and after reperfusion from the inferior caval effluent or the portal veins for calculation of transliver differences (Δ). Hemodynamics and vasoactive medication use during the reperfusion period were observed in both groups.
  
  
  RESULTS
  No transhepatic changes in protein C were found in either group. Immediately after reperfusion, a marked intraliver consumption of APC was noted in all recipients (P < 0.001), and intraliver consumption of APC in the control group was greater than that in the EACA-treated group (P < 0.05). Fewer requirements for vasoactive medication use after reperfusion and better initial graft function were noted in the EACA-treated group (P < 0.05).
  
  
  CONCLUSIONS
  EACA can attenuate intraliver APC consumption and improve hemodynamic stability after reperfusion and initial graft function during OLT.
authors.affiliation: Department of Anesthesiology, 1st Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China, hzkhy@163.com.
authors.forename: H Y
authors.initials: HY
authors.lastname: Kong
authors.forename: X H
authors.initials: XH
authors.lastname: Wen
authors.forename: S Q
authors.initials: SQ
authors.lastname: Huang
authors.forename: S M
authors.initials: SM
authors.lastname: Zhu
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology*; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D016031:Liver Transplantation; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*
chemical_list: D011486:Protein C; D015119:Aminocaproic Acid