title: Are short telomeres predictive of advanced cancer?
abstract: The combination of variable telomere length in cancer cells and shorter telomere length in cancer-associated stromal cells strongly correlates with progression to prostate cancer metastasis and cancer death. The implication is that telomere length measurements have potential not only as prognostic indicators of prostate cancer outcomes but also as risk stratification enrichment biomarkers for individualized therapeutic interventions.
authors.affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Shay
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D018450:Disease Progression; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics*; D057285:Precision Medicine; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D051381:Rats; D016615:Telomere / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor