title: Apelin in ST segment elevation and non-ST segment elevation acute coronary syndromes: a novel finding.
abstract: BACKGROUND
  Apelin is a novel endogenous peptide with inotropic and vasodilatory properties.
  
  
  OBJECTIVE
  To investigate the role of apelin in the prognosis of acute coronary syndromes (ACS) and to assess the relationship between apelin and other diagnostic and prognostic markers.
  
  
  METHODS
  Seventy-six patients with ACS (mean age 62.1 ± 10 years) were evaluated in terms of their plasma apelin-36 concentrations, ejection fraction (EF), high sensitivity C-reactive protein (hsCRP), creatine kinase (CK), CK-MB and troponin I levels. The study group consisted of 35 ST elevation myocardial infarction (STEMI) and 41 non-ST elevation (NSTE) ACS patients. Patients were followed up for one year for cardiovascular outcomes.
  
  
  RESULTS
  There was no significant relationship between apelin and TIMI, GRACE, GENSINI scores, hsCRP and EF in STEMI and NSTE-ACS groups (p > 0.05). Apelin showed positive correlations with CK, CK-MB and troponin I in patients with NSTE-ACS, but a negative correlation in patients with STEMI (p < 0.05). There were no statistically significant differences between patients reaching the composite end point at one year with regard to apelin levels.
  
  
  CONCLUSIONS
  Apelin was positively correlated with cardiac biomarkers in patients with NSTE-ACS but negatively correlated in patients with STEMI. In STEMI, generally larger amounts of myocardial cells are subjected to infarction compared to NSTE-ACS, which may explain why apelin levels decrease with increasing CK, CK-MB and troponin levels in STEMI patients.
authors.forename: Kahraman
authors.initials: K
authors.lastname: Cosansu
authors.forename: Huseyin Altug
authors.initials: HA
authors.lastname: Cakmak
authors.forename: Baris
authors.initials: B
authors.lastname: Ikitimur
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Public Health. alpincan@yahoo.fr.
authors.forename: Gunay
authors.initials: G
authors.lastname: Can
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Karadag
authors.forename: Lale
authors.initials: L
authors.lastname: Koldas
mesh_terms: D000368:Aged; D000073861:Apelin; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology; D011379:Prognosis
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D002097:C-Reactive Protein; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form