title: N-trifluoromethylthiophthalimide: a stable electrophilic SCF3 -reagent and its application in the catalytic asymmetric trifluoromethylsulfenylation.
abstract: Cinchona alkaloid catalysts in combination with air- and moisture-stable N-trifluoromethylthiophthalimide as electrophilic SCF3 source enabled the catalytic enantioselective trifluoromethylsulfenylation. Thus, a series of α-SCF3 esters that bear a quaternary carbon stereogenic center were obtained with excellent yield and enantioselectivity. Moreover, the products can be readily converted into valuable α-SCF3 β-hydroxyesters.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
authors.forename: Teerawut
authors.initials: T
authors.lastname: Bootwicha
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Liu
authors.forename: Roman
authors.initials: R
authors.lastname: Pluta
authors.forename: Iuliana
authors.initials: I
authors.lastname: Atodiresei
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
keywords: cinchona alkaloids; fluorine; indanones; organocatalysis; trifluoromethylsulfenylation