title: Trogocytosis in allogeneic transplants: donor cells take on the recipients identity.
abstract: Trogocytosis has been identified as a mechanism of cell communication between immune cells. Unlike the more common receptor-ligand signaling, trogocytosis results in the transfer of intact and functional surface proteins between cells. For example, antigen presenting cells in contact with T cells exchange proteins which results in the T-cell acquiring antigen presentation capabilities. This allows for the newly activated T cells to stimulate other T cells thus amplifying the immune response. We have recently demonstrated that during allogeneic hematopoietic stem cell transplantation the donor cells obtain recipient MHC class I proteins by trogocytosis. The effect is a donor cell that can masquerade as a recipient cells and evade detection by NK cells and macrophages.
authors.affiliation: Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto, ON Canada; Physiology Department; University of Toronto; Toronto, ON Canada; Obstetrics and Gynaecology Department; University of Toronto; Toronto, ON Canada.
authors.forename: Ian M
authors.initials: IM
authors.lastname: Rogers
mesh_terms: D000818:Animals; D002450:Cell Communication; D006085:Graft Survival / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D014184:Transplantation, Homologous
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: NK cells; NOD/SCID; allogeneic; bone marrow; hematopoietic; macrophages; transplantation; trogocytosis