title: Tooth loss may predict poor cognitive function in community-dwelling adults without dementia or stroke: the PRESENT project.
abstract: Periodontal disease is a potential predictor of stroke and cognitive impairment. However, this association is unclear in adults aged 50 yr and above without a history of stroke or dementia. We evaluated the association between the number of teeth lost, indicating periodontal disease, and cognitive impairment in community-dwelling adults without any history of dementia or stroke. Dental examinations were performed on 438 adults older than 50 yr (315 females, mean age 63±7.8 yr; 123 males, mean age 61.5±8.5 yr) between January 2009 and December 2010. In the unadjusted analysis, odds ratios (OR) of cognitive impairment based on MMSE score were 2.46 (95% CI, 1.38-4.39) and 2.7 (95% CI, 1.57-4.64) for subjects who had lost 6-10 teeth and those who had lost more than 10 teeth, respectively, when compared with subjects who had lost 0-5 teeth. After adjusting for age, education level, hypertension, diabetes, hyperlipidemia, and smoking, the relationship remained significant (OR, 2.0; 95% CI, 1.08-3.69, P=0.027 for those with 6-10 teeth lost; OR, 2.26; 95% CI, 1.27-4.02, P=0.006 for those with more than 10 teeth lost). The number of teeth lost is correlated with cognitive impairment among community-dwelling adults aged 50 and above without any medical history of stroke or dementia.
authors.affiliation: Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Clinical Medicine, Iksan, Korea.
authors.forename: Hyunyoung
authors.initials: H
authors.lastname: Park
authors.forename: Seung-Han
authors.initials: SH
authors.lastname: Suk
authors.forename: Jin-Sung
authors.initials: JS
authors.lastname: Cheong
authors.forename: Hak-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Hyuk
authors.initials: H
authors.lastname: Chang
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Do
authors.forename: Ji-Sook
authors.initials: JS
authors.lastname: Kang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D003704:Dementia / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000150:complications; D012111:Residence Characteristics; D020521:Stroke / Q000473:pathology; D016388:Tooth Loss
keywords: Cognitive Impairment; Dementia; Oral Health; Tooth Loss