title: Proteomics and metabolomics in cancer drug development.
abstract: In this review article, the main recent advancements in the field of proteomics and metabolomics and their application in cancer research are described. In the second part of the review the main metabolic alterations observed in cancer cells are thoroughly dissected, especially those involving anabolic pathways and NADPH-generating pathways, which indirectly affect anabolic reactions, other than the maintenance of the redox poise. Alterations to mitochondrial pathways and thereby deriving oncometabolites are also detailed. The third section of the review is a discussion of how and to what extent (mutations to) tumor suppressors and oncogenes end up influencing cancer cell metabolism and cell fate, either promoting survival and proliferation or autophagy and apoptosis. In the last section of the review, an overview is provided of therapeutic strategies that make use of metabolic reprogramming approaches.
authors.affiliation: Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: D'Alessandro
authors.forename: Lello
authors.initials: L
authors.lastname: Zolla
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000235:genetics; D001343:Autophagy; D055808:Drug Discovery; D015316:Genetic Therapy / Q000379:methods; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D055442:Metabolome; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D020543:Proteome / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D006023:Glycoproteins; D010446:Peptide Fragments; D010750:Phosphoproteins; D020543:Proteome; D016159:Tumor Suppressor Protein p53; C509415:p53 protein (325-355), human