title: Effects of montelukast sodium on tendon healing: An experimental study.
abstract: BACKGROUND
  Montelukast sodium (MS) a selective leukotriene antagonist of the cysteinyl leukotriene receptor, has been used in the treatment of asthma and allergic rhinitis. In this study, we evaluated the effect of MS on the early inflammatory phase (histological) of nonsynovial tendon healing.
  
  
  METHODS
  Rats were divided randomly into two groups (n = 6 each). MS (Singulair) was administered to one group at 10 mg/kg/day [250 g/day intraperitoneally (i.p.)]. The control group was administered 250 g/day of 0.9% saline i.p. This nonsynovial tendon was longitudinally divided at the midportion, cut transversely and then sutured. In both groups, the rats were sacrificed by decapitation 10 days later.
  
  
  RESULTS
  Decreased inflammatory cell infiltration and more properly oriented collagen fibres were observed in the MS group's histopathological specimens as compared to the control group's (P < 0.05). Additionally, vascularity was decreased in the MS group.
  
  
  CONCLUSIONS
  MS decreased tendon healing, apparently by inhibiting the early inflammatory phase of nonsynovial tendon healing.
authors.affiliation: Haydarpaşa Numune Research and Educational Hospital, İstanbul-Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Polat
authors.forename: Mehmet Kerem
authors.initials: MK
authors.lastname: Canbora
authors.forename: Dilek
authors.initials: D
authors.lastname: Akakin
authors.forename: Faruk
authors.initials: F
authors.lastname: Aykanat
keywords: Achilles tendon; montelukast; rats; tendon