title: Primary adenocarcinoma of the lacrimal gland with sebaceous differentiation in a 4-year-old child.
abstract: Primary adenocarcinoma of the lacrimal gland with sebaceous differentiation is an extremely rare tumor. Only 11 cases have been reported in the literature, none in children. A 4-year-old girl presented with a rapidly progressing mass in the left lacrimal gland fossa. An incisional biopsy followed by partial orbital exenteration confirmed the diagnosis of adenocarcinoma with sebaceous cell differentiation. Currently, no previous reports of this malignancy in childhood have been published. This case underscores the necessity of expanding the presenting age that adenocarcinomas with sebaceous differentiation of the lacrimal gland can occur.
authors.affiliation: *Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery and †Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo; ‡Department of Head and Neck Surgery and §Department of Pathology, Institute of Integrative Medicine Professor Fernando Figueira, Recife, Brazil; and ‖King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Carlos G M G
authors.initials: CG
authors.lastname: Lima
authors.forename: Fernando
authors.initials: F
authors.lastname: Chahud
authors.forename: Christiano J K
authors.initials: CJ
authors.lastname: Paiva
authors.forename: Danielle
authors.initials: D
authors.lastname: Nebl
authors.forename: Antonio Augusto V
authors.initials: AA
authors.lastname: Cruz
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D012626:Sebaceous Gland Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor