title: Thrombotic thrombocytopenic purpura secondary to ABO group incompatible blood transfusion in a patient after cardiac surgery.
abstract: The triggers of secondary thrombotic thrombopcytopenic purpura (TTP) include drug toxicity, radiation and high-dose chemotherapy, angioinvasive infections, surgery and acute graft versus host disease. TTP secondary to surgery have been reported in a number of cases. Most of the cases have been occurred after open heart surgery. Extensive endothelial damage is held responsible as the initiating mechanism in postoperative TTP cases. However, there is no report of secondary TTP describing development owing to ABO incompatible blood transfusion. Here, we describe a patient who developed TTP after transfusion of ABO incompatible blood during hospitalization for bypass surgery. We also propose a hypothesis which may account for the possible underlying mechanism.
authors.affiliation: Department of Nephrology, Konya University Meram School of Medicine, Meram, Konya, Turkey.
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Nedim Yilmaz
authors.initials: NY
authors.lastname: Selcuk
authors.forename: Abduzhappar
authors.initials: A
authors.lastname: Gaipov
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ucar
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Biyik
authors.forename: Kadir
authors.initials: K
authors.lastname: Acar
keywords: ABO incompatible; blood transfusion; coronary artery bypass grafting surgery; thrombotic thrombocytopenic purpura