title: Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system.
abstract: Aeromonas salmonicida subsp. salmonicida is an important pathogen in salmonid aquaculture and is responsible for the typical furunculosis. The type-three secretion system (T3SS) is a major virulence system. In this work, we review structure and function of this highly sophisticated nanosyringe in A. salmonicida. Based on the literature as well as personal experimental observations, we document the genetic (re)organization, expression regulation, anatomy, putative functional origin and roles in the infectious process of this T3SS. We propose a model of pathogenesis where A. salmonicida induces a temporary immunosuppression state in fish in order to acquire free access to host tissues. Finally, we highlight putative important therapeutic and vaccine strategies to prevent furunculosis of salmonid fish.
authors.affiliation: Institute of Veterinary Bacteriology, University of Bern, Länggassstrasse 122, Bern, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanden Bergh
authors.forename: Joachim
authors.initials: J
authors.lastname: Frey
mesh_terms: D048409:Aeromonas salmonicida / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000662:veterinary; D058947:Bacterial Secretion Systems; D005393:Fish Diseases / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D023061:Gene Order; D057131:Immune Evasion; D007108:Immune Tolerance; D046911:Macromolecular Substances / Q000378:metabolism*; D012487:Salmonidae / Q000382:microbiology; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D058947:Bacterial Secretion Systems; D046911:Macromolecular Substances; D037521:Virulence Factors