title: Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.
abstract: Human respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in young children, immunocompromised adults, and the elderly. The innate immune response plays a pivotal role in host defense against RSV, but whether severe outcomes following RSV infection result from excessive or poor innate immune recognition remains unclear. Recent research suggests a situation in which crosstalk between families of pattern recognition receptors (PRRs) occurs in a cell type-dependent manner. The current challenge to empower novel therapeutic approaches and vaccine development is to confirm the role of the individual receptors in RSV pathogenesis in humans.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Child & Family Research Institute, Vancouver, BC V5Z 4H4, Canada.
authors.forename: Nico
authors.initials: N
authors.lastname: Marr
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Turvey
authors.forename: Nathalie
authors.initials: N
authors.lastname: Grandvaux
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000276:immunology / Q000378:metabolism; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000473:pathology*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition
keywords: innate immunity; pathogen recognition receptors; pathogenesis; respiratory syncytial virus