title: GRK 2 level in peripheral blood lymphocytes of elderly patients with acute myocardial infarction.
abstract: OBJECTIVE
  To investigate the G protein-coupled receptor kinase 2 (GRK 2) level in peripheral blood lymphocytes with cardiac function in elderly patients with acute myocardial infarction.
  
  
  METHODS
  This study enrolled 40 patients with acute ST-segment elevation myocardial infarction (STEMI) and 40 patients with unstable angina. All patients were 65 years or older. Cardiac function was evaluated by echocardiography, and the GRK 2 level in peripheral blood lymphocytes was measured. Patients with STEMI were followed up for 2 years.
  
  
  RESULTS
  The GRK 2 level in peripheral blood lymphocytes was significantly higher in patients with STEMI than in patients with unstable angina, and was negatively correlated with left ventricular ejection fraction, cardiac output, stroke volume, and left ventricular fractional shortening. The GRK 2 level was significantly elevated in some patients with acute STEMI and poor cardiac function.
  
  
  CONCLUSIONS
  Increased GRK 2 level in patients with acute STEMI may contribute to poor myocardial systolic function and myocardial remodeling. Measurement of the GRK 2 level in peripheral blood lymphocytes may assist in the evaluation of cardiac function and myocardial remodeling in elderly patients with acute STEMI.
authors.affiliation: The First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wen-Qian
authors.initials: WQ
authors.lastname: Gao
authors.forename: Chun-Guang
authors.initials: CG
authors.lastname: Han
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Lu
authors.forename: Yong-Xue
authors.initials: YX
authors.lastname: Liu
authors.forename: Hai-Peng
authors.initials: HP
authors.lastname: Hui
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
keywords: G protein-coupled receptor kinase 2; Heart function; ST-segment elevation myocardial infarction