title: Anti-inflammatory activity of TS-13, ARE-inducing phenol antioxidant.
abstract: The protective effect of water-soluble TS-13 monophenol inducing the antioxidant-responsive element (ARE) system was studied on the models of acute inflammation. Intragastric administration of TS-13 to rats significantly reduced the severity of acute aseptic inflammation induced by intravenous injection of zymosan particles: granulocyte blood count and volume density of infiltrates in the liver decreased on day 3, spontaneous production of activated oxygen metabolites and respiratory burst in blood granulocytes decreased on days 2 and 3. A single dose of TS-13 improved survival of mice with endotoxin shock induced by intraperitoneal injection of E. coli LPS. These results confirmed high anti-inflammatory activity of TS-13.
authors.affiliation: Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Novosibirsk State Pedagogical University, Russia. lemen@soramn.ru.
authors.forename: E B
authors.initials: EB
authors.lastname: Menshchikova
authors.forename: V O
authors.initials: VO
authors.lastname: Tkachev
authors.forename: N K
authors.initials: NK
authors.lastname: Zenkov
authors.forename: A E
authors.initials: AE
authors.lastname: Lemza
authors.forename: T V
authors.initials: TV
authors.lastname: Sharkova
authors.forename: N V
authors.initials: NV
authors.lastname: Kandalintseva
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D061745:Antioxidant Response Elements / Q000187:drug effects* / Q000502:physiology; D006098:Granulocytes / Q000502:physiology; D007249:Inflammation / Q000188:drug therapy*; D053208:Kaplan-Meier Estimate; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017208:Rats, Wistar; D016897:Respiratory Burst / Q000502:physiology; D013886:Thiosulfonic Acids / Q000494:pharmacology*; D015054:Zymosan
chemical_list: C553321:3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonic acid; D000893:Anti-Inflammatory Agents; D013886:Thiosulfonic Acids; D015054:Zymosan