title: Treatment of wounds colonized by multidrug resistant organisms in immune-compromised patients: a retrospective case series.
abstract: BACKGROUND
  Immune-compromised patients incur a high risk of surgical wound dehiscence and colonization by multidrug resistant organisms. Common treatment has been debridement and spontaneous secondary healing.We report on the results obtained in nine such patients whose wounds were treated by debridement, negative pressure dressing and direct closure.
  
  
  METHODS
  All immune-compromised patients referred to our Institution between March 1, 2010 and November 30, 2011 for dehiscent abdominal wounds growing multidrug resistant organisms were treated by serial wound debridements and negative pressure dressing. They were primarily closed, despite positive microbiological cultures, when clinical appearance was satisfactory.As a comparison, records from patients treated between March 1, 2008 and February 28, 2010 who, according to our Institution's policy at that time, had been left to heal by secondary intention, were retrieved and examined.
  
  
  RESULTS
  Nine patients were treated by direct wound closure, five had been treated previously by secondary intention healing.Overall, ten patients had received liver transplant, 1 kidney transplant, 1 was HIV infected, 1 suffered from multi-organ failure, 1 was undergoing hemodialysis.Wound dehiscence involved skin and subcutaneous layers in all patients, in two the muscular layer was also involved.Mean healing time was significantly shorter in patients treated more recently by primary intention in comparison with historical patients (28 vs 81 days). The only complication observed was a small superficial abscess that developed around a non-absorbable stitch 10 months after closure in a patient treated by primary closure.
  
  
  CONCLUSIONS
  According to our results, fast healing can be safely obtained by closure of a clinically healthy wound, despite growth of multidrug resistant organisms, even in immune-compromised patients.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Policlinico of Modena,University of Modena and Reggio Emilia, Via del Pozzo 71, Modena I - 41124, Italy. mrpignatti@googlemail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Pignatti
authors.forename: Giorgio Enrico
authors.initials: GE
authors.lastname: Gerunda
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rompianesi
authors.forename: Nicola
authors.initials: N
authors.lastname: De Ruvo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Di Benedetto
authors.forename: Mauro
authors.initials: M
authors.lastname: Codeluppi
authors.forename: Decenzio
authors.initials: D
authors.lastname: Bonucchi
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Pacchioni
authors.forename: Pietro
authors.initials: P
authors.lastname: Loschi
authors.forename: Cristina
authors.initials: C
authors.lastname: Malaventura
authors.forename: Giorgio
authors.initials: G
authors.lastname: De Santis