title: γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery.
abstract: The stability and compatibility of designed coiled coil peptides towards the selective incorporation of γ(4)-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of γ(4)-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research, Dr Homi Bhabha Road, Pune 411 008, India. hn.gopi@iiserpune.ac.in.
authors.forename: Sandip V
authors.initials: SV
authors.lastname: Jadhav
authors.forename: Sumeet K
authors.initials: SK
authors.lastname: Singh
authors.forename: Rahi M
authors.initials: RM
authors.lastname: Reja
authors.forename: Hosahudya N
authors.initials: HN
authors.lastname: Gopi
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D005456:Fluorescent Dyes / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D008969:Molecular Sequence Data; D009154:Mutation; D010455:Peptides / Q000737:chemistry* / Q000235:genetics*; D017433:Protein Structure, Secondary; D013696:Temperature
chemical_list: D000596:Amino Acids; D005456:Fluorescent Dyes; D008081:Liposomes; D010455:Peptides