title: Corpus callosum shape and size changes in early Alzheimer's disease: a longitudinal MRI study using the OASIS brain database.
abstract: BACKGROUND
  Alzheimer's disease (AD) has been shown to be associated with shrinkage of the corpus callosum mid-sagittal cross-sectional area (CCA).
  
  
  OBJECTIVE
  To study temporal rates of corpus callosum atrophy not previously reported for early AD.
  
  
  METHODS
  We used longitudinal MRI scans to study the rates of change of CCA and circularity (CIR), a measure of its shape, in normal controls (NC, n = 75), patients with very mild AD (AD-VM, n = 51), and mild AD (AD-M, n = 21).
  
  
  RESULTS
  There were significant reduction rates in CCA and CIR in all three groups. While CCA reduction rates were not statistically different between groups, the CIR declined faster in AD-VM (p < 0.03) and AD-M (p < 0.0001) relative to NC, and in AD-M relative to AD-VM (p < 0.0004).
  
  
  CONCLUSIONS
  CIR declines at an accelerated rate with AD severity. Its rate of change is more closely associated with AD progression than CCA or any of its sub-regions. CIR may be a useful group biomarker for objective assessment of treatments that aim to slow AD progression.
authors.affiliation: The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
authors.forename: Alvin H
authors.initials: AH
authors.lastname: Bachman
authors.affiliation: The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
authors.forename: Sang Han
authors.initials: SH
authors.lastname: Lee
authors.affiliation: The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Sidtis
authors.affiliation: The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
authors.forename: Babak A
authors.initials: BA
authors.lastname: Ardekani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values
keywords: Alzheimer's disease; brain; circularity; corpus callosum; magnetic resonance imaging; shape analysis