title: Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice.
abstract: OBJECTIVE
  To evaluate the effects of crude extract of Euphorbia tirucalli in cutaneous wound healing.
  
  
  METHODS
  A total of 20 Swiss mice were randomly divided into two groups, aveloz (GA) and control (CG), and each group was further divided into two subgroups based on the deaths scheduled for the 7th and 14th days after surgery. The animals underwent a resection of cutaneous fragment with 1cm in diameter on the dorsum; the GA was applied in each animal on the subsequent days, 0.1 mL (30 mg/mL) hydroalcoholic extract of Euphorbia tirucalli was applied on the wound, while the same volume of 0.9% saline solution was applied to the GC. It was evaluated the lesion diameter and after programmed death, a surgical specimen was resected for histopathology.
  
  
  RESULTS
  In the macroscopic analysis, no statistically significant difference was observed (p = 0.120 and p = 0.186, for the 7th and 14th days of death, respectively). The histological evaluation revealed no statistically significant difference in the variables acute inflammation (p = 0.014) and fibrosis (p = 0.018), when compared the group aveloz with the control group on day 14.
  
  
  CONCLUSIONS
  The crude hydroalcoholic extract of Euphorbia tirucalli L. demonstrated better outcomes in the healing process, acute inflammation and fibrosis on the 14 day postoperatively.
authors.forename: Euler Nicolau
authors.initials: EN
authors.lastname: Sauaia Filho
authors.forename: Orlando José dos
authors.initials: OJ
authors.lastname: Santos
authors.forename: Allan Kardec Duailibe
authors.initials: AK
authors.lastname: Barros Filho
authors.forename: Altieres de Arruda
authors.initials: Ade A
authors.lastname: Rocha
authors.forename: Rafael Campos
authors.initials: RC
authors.lastname: Silva
authors.forename: Rayan Haquim Pinheiro
authors.initials: RH
authors.lastname: Santos
authors.forename: Rennan Abud Pinheiro
authors.initials: RA
authors.lastname: Santos
mesh_terms: D000818:Animals; D028481:Euphorbia / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D005355:Fibrosis; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts