title: Akaeolide, a carbocyclic polyketide from marine-derived Streptomyces.
abstract: Akaeolide, a novel polycyclic polyketide, was isolated from the culture extract of a marine-derived actinomycete belonging to the genus Streptomyces. The planar structure of the new compound was elucidated by spectroscopic analysis including NMR and MS, and the absolute configuration was determined by X-ray crystallographic analysis of its chlorinated derivative. Akaeolide possesses a 15-membered carbocyclic framework, apparently derived from the malonate pathway, with a tetrahydrofuran ring and a β-keto-δ-lactone unit.
authors.affiliation: Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan , Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Tokyo Innovation Center , 1-32-3 Nanakuni, Hachioji, Tokyo 192-0991, Japan , and Application Laboratories, Rigaku Corporation , 3-9-12 Matsubara-cho, Akishima, Tokyo 196-8666, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Seizo
authors.initials: S
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Linkai
authors.initials: L
authors.lastname: Yu
authors.forename: Naoya
authors.initials: N
authors.lastname: Oku
mesh_terms: D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D005663:Furans; D018942:Macrolides; D061065:Polyketides; C587701:akaeolide; C018674:tetrahydrofuran