title: Improvement of restless legs syndrome by varenicline as antismoking treatment.
abstract: Varenicline is a partial agonist at the α4β2 nicotinic acetylcholine receptor effective as smoking cessation pharmacotherapy. We present a familial case of severe restless legs syndrome (RLS) resistant to polytherapy who showed a consistent and effective amelioration of RLS symptoms after introduction of varenicline as antismoking drug.
authors.affiliation: IRCCS Neuromed Istituto Neurologico Mediterraneo Sleep Medicine Center Pozzilli (Is), Italy ; Università di Roma Tor Vergata - Neurophysiopathology Department Sleep & Epilepsy Centre, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Romigi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vitrani
mesh_terms: D000369:Aged, 80 and over; D001552:Benzazepines / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D017060:Patient Satisfaction; D011810:Quinoxalines / Q000627:therapeutic use*; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline
keywords: Restless legs syndrome; nicotinic acetylcholine receptor agonist; varenicline