title: [Reticular drusen over time with SD-OCT].
abstract: OBJECTIVE
  The aim of the study was the analysis of reticular drusen (RDR) in patients with age-related macular degeneration using simultaneous confocal scanning laser ophthalmoscopy (cSLO) and spectral domain optical coherence tomography (SD-OCT) at different time points.
  
  
  METHODS
  Included in this retrospective analysis were 47 eyes from 32 patients (median age 80.1 years, range 66-89 years) with RDR at baseline and at least one follow-up visit. Registration of the cSLO near-infrared reflectance image and the SD-OCT B-scan (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg) at different time points was carried out using the AutoRescan tool.
  
  
  RESULTS
  While either no alterations or increase in the RDR area (n=19 eyes) or RDR density (n=15) were seen by cSLO imaging, the analysis of the SD-OCT B-scans at different time points revealed a more complex picture. An increase in two well visible lesions at the baseline visit was detected in 8 eyes at the first follow-up and in 3 eyes at the second follow-up examination. A regression was seen in 5 eyes at the first follow-up and in 3 eyes at the second follow-up visit. In most eyes (n=23), an increase of one with a parallel decrease of the second RDR lesion in the identical B-scan was identified at the first follow-up visit, whereas individual RDR showed an increase at the second follow-up examination that had initially shown a decrease in size at the first follow-up visit.
  
  
  CONCLUSIONS
  The results indicate underlying dynamic processes in the development and changes of RDR over time. For a more accurate analysis, the exact registration of SD-OCT B-scans at different time points and the use of high-resolution very dense volume scans would be helpful in order to assess such discrete changes of miniscule intraretinal lesions over time.
authors.affiliation: Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Auge
authors.forename: J S
authors.initials: JS
authors.lastname: Steinberg
authors.forename: M
authors.initials: M
authors.lastname: Fleckenstein
authors.forename: F G
authors.initials: FG
authors.lastname: Holz
authors.forename: S
authors.initials: S
authors.lastname: Schmitz-Valckenberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008268:Macular Degeneration / Q000150:complications / Q000473:pathology*; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods*; D015203:Reproducibility of Results; D015593:Retinal Drusen / Q000209:etiology / Q000473:pathology*; D012680:Sensitivity and Specificity; D066167:Slit Lamp; D041623:Tomography, Optical Coherence / Q000379:methods*