title: [Successful use of vemurafenib in a patient with resistant hairy cell leukemia].
abstract: The paper describes a case of a patient with refractory hairy cell leukemia. In spite of the absence of CD25 expression, the disease was classified as a classical form according to the WHO classification (2008), as also confirmed by the detection of BRAFV600E mutation. The disease was characterized by resistance to all lines of therapy (interferon-a, splenectomy, cladribin). Clinical and hematological remission was achieved within 2 months of administration of the BRAF kinase inhibitor vemurafenib.
authors.forename: E S
authors.initials: ES
authors.lastname: Urnova
authors.forename: L S
authors.initials: LS
authors.lastname: Al'-Radi
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: A A
authors.initials: AA
authors.lastname: Kariakina
authors.forename: A M
authors.initials: AM
authors.lastname: Kovrigina
authors.forename: V N
authors.initials: VN
authors.lastname: Dvirnyk
authors.forename: I A
authors.initials: IA
authors.lastname: Iakutik
authors.forename: A B
authors.initials: AB
authors.lastname: Sudarikov
authors.forename: E N
authors.initials: EN
authors.lastname: Parovichnikova
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013156:Splenectomy; D013163:Splenomegaly / Q000150:complications / Q000601:surgery; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib