title: Lack of association of S100β and neuron-specific enolase with mortality in critically ill patients.
abstract: OBJECTIVE
  To evaluate the relationship between brain damage biomarkers and mortality in the intensive care unit (ICU).
  
  
  METHODS
  The sample comprised 70 patients admitted to an ICU. Blood samples were collected from all patients on ICU admission, and levels of S100β and neuron-specific enolase (NSE) were determined by ELISA.
  
  
  RESULTS
  Acute Physiologic and Chronic Health Evaluation (APACHE II) score was associated with mortality, but NSE and S100β were not associated with this outcome. In contrast, S100β levels were significantly higher in delirious and non-delirious patients who required mechanical ventilation during ICU stay.
  
  
  CONCLUSIONS
  Levels of brain biomarkers at the time of ICU admission did not predict mortality in critically ill patients.
authors.affiliation: National Science and Technology Institute for Translational Medicine, Laboratory of Experimental Pathophysiology, CriciúmaSC, Brazil.
authors.forename: Roberta Candal de
authors.initials: RC
authors.lastname: Macedo
authors.forename: Cristiane Damiani
authors.initials: CD
authors.lastname: Tomasi
authors.forename: Vinicius René
authors.initials: VR
authors.lastname: Giombelli
authors.forename: Sarah Cascaes
authors.initials: SC
authors.lastname: Alves
authors.forename: Maria de Lourdes Ugioni
authors.initials: Mde L
authors.lastname: Bristot
authors.forename: Maria Fernanda Topanotti
authors.initials: MF
authors.lastname: Locks
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Carmen
authors.initials: C
authors.lastname: Grandi
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Cristiane
authors.initials: C
authors.lastname: Ritter
mesh_terms: D018806:APACHE; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000401:mortality*; D016022:Case-Control Studies; D016638:Critical Illness / Q000401:mortality*; D003693:Delirium / Q000097:blood*; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase