title: The cross-selective titanium(III)-catalysed acyloin reaction.
abstract: A titanium(III)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to α-hydroxylated and α-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed.
authors.affiliation: Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104 Freiburg, Germany. jan.streuff@ocbc.uni-freiburg.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Feurer
authors.forename: Georg
authors.initials: G
authors.lastname: Frey
authors.forename: Hieu-Trinh
authors.initials: HT
authors.lastname: Luu
authors.forename: Daniel
authors.initials: D
authors.lastname: Kratzert
authors.forename: Jan
authors.initials: J
authors.lastname: Streuff