title: Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.
abstract: Cousins you can count on: An iridoid-inspired compound collection was synthesized efficiently by the resolution of cyclic enones in an asymmetric cycloaddition with azomethine ylides. The collection contained novel potent inhibitors of the Wnt and Hedgehog signaling pathways.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany).
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayama
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Jia
authors.forename: Lea
authors.initials: L
authors.lastname: Kremer
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Bauer
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.forename: Slava
authors.initials: S
authors.lastname: Ziegler
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D000818:Animals; D002384:Catalysis; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D061565:Cycloaddition Reaction; D004353:Drug Evaluation, Preclinical; D057809:HEK293 Cells; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D039823:Iridoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D015398:Signal Transduction / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D051153:Wnt Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins; D039823:Iridoids; D051153:Wnt Proteins
keywords: asymmetric catalysis; cycloaddition; inhibitors; iridoids; signaling pathways