title: Plasma-exchange treatment for severe carbamazepine intoxication: a case study.
abstract: Acute poisoning is an important cause of morbidity and mortality during childhood. This manuscript reports the positive outcome of a pediatric case with a history of accidental carbamazepine intake treated using plasma exchange. A 3-year-old male presented with severe carbamazepine intoxication. He was comatose and had generalized tonic clonic seizure, ventricular tachycardia, and hypotension. Although he did not respond to classical therapies, we performed two sessions of plasma exchange. The patient recovered rapidly and was discharged from the hospital six days from the time of carbamazepine ingestion with no complication or neurologic impairment. Plasma exchange can be performed safely in very small children, and it might be the first line treatment, particularly for intoxication with drugs that have high plasma-protein-binding properties.
authors.affiliation: Department of Physiology, Faculty of Medicine, Baskent University, Ankara, Turkey; Adana Adult Bone Marrow Transplantation Center, Apheresis Unit, Baskent University, Ankara, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Kozanoglu
authors.forename: Suat
authors.initials: S
authors.lastname: Kahveci
authors.forename: Suheyl
authors.initials: S
authors.lastname: Asma
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yeral
authors.forename: Aytul
authors.initials: A
authors.lastname: Noyan
authors.forename: Can
authors.initials: C
authors.lastname: Boga
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdogu
mesh_terms: D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D002220:Carbamazepine / Q000097:blood / Q000506:poisoning*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D010951:Plasma Exchange / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine
keywords: acute poisoning; carbamazepine; childhood; plasma exchange