title: Babesia canis vogeli, Ehrlichia canis, and Anaplasma platys infection in a dog.
abstract: A 12-month-old male neutered mixed breed dog was presented with a history of diarrhea, lethargy, emaciation, polydypsia, and sniffling. Physical examination findings included pale mucous membranes, increased heart and respiratory rates, and normal rectal temperature (38°C). Hematologic abnormalities included anemia and thrombocytopenia. Biochemical abnormalities included hypoalbuminemia, hyperbilirubinemia, and elevated ALP and ALT activities. A SNAP 4Dx test result was positive for Ehrlichia canis. Babesia canis vogeli organisms were found in the peripheral blood films, while morulae of E canis were not seen. Real-time polymerase chain reaction testing confirmed the presence of both B c vogeli and E canis organisms, and also was positive for Anaplasma platys infection. The dog recovered following treatment with doxycycline and imidocarb dipropionate, with normal hematology and biochemical profiles.
authors.affiliation: IDEXX Reference Laboratories, Markham, ON, Canada.
authors.forename: Salah
authors.initials: S
authors.lastname: Al Izzi
authors.forename: Donald S
authors.initials: DS
authors.lastname: Martin
authors.forename: Roxanne Y Y
authors.initials: RY
authors.lastname: Chan
authors.forename: Christian M
authors.initials: CM
authors.lastname: Leutenegger
mesh_terms: D000709:Anaplasma / Q000235:genetics / Q000302:isolation & purification; D000712:Anaplasmosis / Q000175:diagnosis* / Q000188:drug therapy; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001403:Babesia / Q000235:genetics / Q000302:isolation & purification; D001404:Babesiosis / Q000175:diagnosis* / Q000188:drug therapy; D001774:Blood Chemical Analysis / Q000662:veterinary; D060085:Coinfection / Q000662:veterinary; D016054:DNA, Protozoan / Q000097:blood; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use; D041061:Ehrlichia canis / Q000235:genetics / Q000302:isolation & purification*; D016873:Ehrlichiosis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D006403:Hematologic Tests / Q000662:veterinary; D007095:Imidocarb / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D018512:Parasitemia / Q000662:veterinary; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D053058:Trophozoites
chemical_list: D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D016054:DNA, Protozoan; D007095:Imidocarb; D004318:Doxycycline; C031719:imidocarb dipropionate
keywords: Coinfection; SNAP 4Dx; hemoparasites; real-time PCR; tick-borne diseases