title: Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer.
abstract: Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.
authors.affiliation: Department of Human DNA Variability, University of Granada, GENYO: Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avenue de la Ilustracion, 114, 18016 Granada, Spain.
authors.forename: Martin
authors.initials: M
authors.lastname: Muñoz-Lopez
authors.forename: Pedro P
authors.initials: PP
authors.lastname: Medina
authors.forename: Jose L
authors.initials: JL
authors.lastname: Garcia-Perez
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D019313:BRCA1 Protein / Q000378:metabolism*; D019175:DNA Methylation; D006570:Heterochromatin / Q000378:metabolism*; D006801:Humans; D008297:Male; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D000071636:Protein Phosphatase 2C
chemical_list: D019313:BRCA1 Protein; D006570:Heterochromatin; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse; C000607458:PPM1D protein, human; D010749:Phosphoprotein Phosphatases; C000607468:Ppm1d protein, mouse; D000071636:Protein Phosphatase 2C