title: [Effects on the secretion of reproductive hormones in adult female rats exposed to lipopolysaccharide in neonatal life].
abstract: OBJECTIVE
  To explore whether neonatal endotoxin challenge alters reproductive hormone secretion in adult female rats.
  
  
  METHODS
  Rats were intraperitoneally injected with lipopolysaccharide (LPS) or normal saline at postnatal days 3 and 5. At Week 12, the animals underwent bilateral oophorectomy and were exposed to LPS or saline. The secretion levels of luteinizing hormone (LH) and estradiol were measured.
  
  
  RESULTS
  The LPS injection in adult neonatal saline rats caused the suppressed secretion of LH and estradiol. However, the decreased secretion of both LH and estradiol were much more apparent in adult neonatal LPS-treated rats.
  
  
  CONCLUSIONS
  The neonatal LPS challenge alters the secretions of LH and estradiol during adulthood. And the mechanism may be mediated by epigenetic programming of hypothalamic-pituitary-gonadal axis.
authors.affiliation: Department of Obstetrics & Gynecology; Department of Cardiology, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Xue-qing
authors.initials: XQ
authors.lastname: Wu
authors.forename: Qiang-yong
authors.initials: QY
authors.lastname: Zhou
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Chen
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Li
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004249:DNA Damage; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity*; D007986:Luteinizing Hormone / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008070:Lipopolysaccharides; D004958:Estradiol; D007986:Luteinizing Hormone