title: Neural coupling of cooperative hand movements: a reflex and fMRI study.
abstract: The neural control of "cooperative" hand movements reflecting "opening a bottle" was explored in human subjects by electromyographic (EMG) and functional magnetic resonance imaging (fMRI) recordings. EMG responses to unilateral nonnoxious ulnar nerve stimulation were analyzed in the forearm muscles of both sides during dynamic movements against a torque applied by the right hand to a device which was compensated for by the left hand. For control, stimuli were applied while task was performed in a static/isometric mode and during bilateral synchronous pro-/supination movements. During the dynamic cooperative task, EMG responses to stimulations appeared in the right extensor and left flexor muscles, regardless of which side was stimulated. Under the control conditions, responses appeared only on the stimulated side. fMRI recordings showed a bilateral extra-activation and functional coupling of the secondary somatosensory cortex (S2) during the dynamic cooperative, but not during the control, tasks. This activation might reflect processing of shared cutaneous input during the cooperative task. Correspondingly, it is assumed that stimulation-induced unilateral volleys are processed in S2, leading to a release of EMG responses to both forearms. This indicates a task-specific neural coupling during cooperative hand movements, which has consequences for the rehabilitation of hand function in poststroke patients.
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, 8008 Zurich, Switzerland and.
authors.forename: Volker
authors.initials: V
authors.lastname: Dietz
authors.affiliation: Clinic of Neuroradiology, University Hospital of Zurich, 8001 Zurich, Switzerland.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Macauda
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, 8008 Zurich, Switzerland and.
authors.forename: Miriam
authors.initials: M
authors.lastname: Schrafl-Altermatt
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, 8008 Zurich, Switzerland and.
authors.forename: Markus
authors.initials: M
authors.lastname: Wirz
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, 8008 Zurich, Switzerland and.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Kloter
authors.affiliation: Clinic of Neuroradiology, University Hospital of Zurich, 8001 Zurich, Switzerland.
authors.forename: Lars
authors.initials: L
authors.lastname: Michels
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D007839:Functional Laterality; D006225:Hand / Q000502:physiology*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011601:Psychophysics; D012018:Reflex / Q000502:physiology*; D019415:Torque; D014459:Ulnar Nerve / Q000502:physiology
keywords: bilateral reflex responses; hand function; motor control; secondary somatosensory cortex; unilateral nerve stimulation