title: Morphological validation of hydroxyethylstarch use during the acute period of severe brain injury.
abstract: The effects of 10% hydroxyethylstarch solution on the cerebral microcirculatory bed and the blood-brain barrier were studied in Wistar rats during the acute period of severe brain injury. Positive changes in the morphometric values of the cerebral capillaries were observed in animals receiving intravenous injections of the drug, which promoted reduction of vascular permeability and cerebral tissue edema. These results confirmed the efficiency of hydroxyethylstarch as a component of infusion therapy in patients with severe brain injury.
authors.affiliation: Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok; Vladivostok State Medical University, Russia. l_somova@mail.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.forename: M A
authors.initials: MA
authors.lastname: Moldavanov
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.forename: V B
authors.initials: VB
authors.lastname: Shumatov
mesh_terms: D000210:Acute-Phase Reaction / Q000188:drug therapy*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001930:Brain Injuries / Q000188:drug therapy*; D004730:Endothelium, Vascular / Q000187:drug effects*; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007262:Infusions, Intravenous; D008297:Male; D008854:Microscopy, Electron; D055806:Microvessels / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats
chemical_list: D006895:Hydroxyethyl Starch Derivatives; C517718:hydroxyethylstarch 200