title: Significance of the natural occurrence of L- versus D-pipecolic acid: a review.
abstract: Pipecolic acid naturally occurs in microorganisms, plants, and animals, where it plays many roles, including the interactions between these organisms, and is a key constituent of many natural and synthetic bioactive molecules. This article provides a review of current knowledge on the natural occurrence of pipecolic acid and the known and potential significance of its L- and D-enantiomers in different scientific disciplines. Knowledge gaps with perspectives for future research identified within this article include the roles of the L- versus the D-enantiomer of pipecolic acid in plant resistance, nutrient acquisition, and decontamination of polluted soils, as well as rhizosphere ecology and medical issues.
authors.affiliation: Mendel University in Brno, Department of Geology and Soil Science, Czech Republic.
authors.forename: Valerie
authors.initials: V
authors.lastname: Vranova
authors.forename: Lea
authors.initials: L
authors.lastname: Lojkova
authors.forename: Klement
authors.initials: K
authors.lastname: Rejsek
authors.forename: Pavel
authors.initials: P
authors.lastname: Formanek
mesh_terms: D010875:Pipecolic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification*; D010944:Plants / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010875:Pipecolic Acids; C031345:pipecolic acid
keywords: enantiomer; interactions; medicine; microorganisms; pipecolic acid; plants; soil