title: Self-assembled nanoparticles based on galactosylated O-carboxymethyl chitosan-graft-stearic acid conjugates for delivery of doxorubicin.
abstract: A novel polymer, i.e. galactosylated O-carboxymethyl chitosan-graft-stearic acid (Gal-OCMC-g-SA) was synthesized for liver targeting delivery of doxorubicin. The chemical structure was characterized by FT-IR, (1)H NMR and elemental analysis. Gal-OCMC-g-SA could self-assemble into nanoparticles with diameter of 160 nm by probe sonication in aqueous medium and exhibited a low critical aggregation concentration of 0.047 mg/mL. The DOX-loaded Gal-OCMC-g-SA (Gal-OCMC-g-SA/DOX) self-assembled nanoparticles were almost spherical in shape with an average diameter of less than 200 nm and zeta potential of around -10 mV. In vitro release revealed that the Gal-OCMC-g-SA/DOX nanoparticles exhibited a sustained and pH-dependent drug release manner. Furthermore, the hemolysis test demonstrated the good safety of Gal-OCMC-g-SA in blood-contacting applications. These results indicated that Gal-OCMC-g-SA/DOX nanoparticles were highly potential to be applied in cancer therapy.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xilu, Jinan 250012, PR China.
authors.forename: Hejian
authors.initials: H
authors.lastname: Guo
authors.forename: Dianrui
authors.initials: D
authors.lastname: Zhang
authors.forename: Caiyun
authors.initials: C
authors.lastname: Li
authors.forename: Lejiao
authors.initials: L
authors.lastname: Jia
authors.forename: Guangpu
authors.initials: G
authors.lastname: Liu
authors.forename: Leilei
authors.initials: L
authors.lastname: Hao
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.forename: Jingyi
authors.initials: J
authors.lastname: Shen
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D008099:Liver / Q000378:metabolism; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D013229:Stearic Acids / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; C504164:O-carboxymethylchitosan; D011108:Polymers; D013229:Stearic Acids; C031183:stearic acid; D004317:Doxorubicin; D048271:Chitosan
keywords: Doxorubicin; Liver targeting; O-carboxymethyl chitosan; Stearic acid