title: Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing.
abstract: Due to the close interactions between the skin and peripheral nervous system, there is increasing evidence that the cutaneous innervation is an important modulator of the normal wound healing process. The communication between sensory neurons and skin cells involves a variety of molecules (neuropeptides, neurohormones, and neurotrophins) and their specific receptors expressed by both neuronal and nonneuronal skin cells. It is well established that neurotransmitters and nerve growth factors released in skin have immunoregulatory roles and can exert mitogenic actions; they could also influence the functions of the different skin cell types during the wound healing process.
authors.affiliation: Laboratory of Neurosciences of Brest (EA4685), University of Western Brittany, Brest, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Chéret
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lebonvallet
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Carré
authors.forename: Laurent
authors.initials: L
authors.lastname: Misery
authors.forename: Christelle
authors.initials: C
authors.lastname: Le Gall-Ianotto
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D020078:Neurogenic Inflammation / Q000276:immunology* / Q000503:physiopathology; D009479:Neuropeptides / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010525:Peripheral Nerves / Q000276:immunology / Q000503:physiopathology; D012867:Skin / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology* / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000276:immunology*
chemical_list: D009414:Nerve Growth Factors; D009479:Neuropeptides; D018377:Neurotransmitter Agents