title: Phase-field approach to chemotactic driving of neutrophil morphodynamics.
abstract: To simulate the motion of neutrophils and their morphodynamics in response to chemical cues, we construct a model based on the phase-field method utilizing a description with a free-energy functional and associated dynamics which captures the basic features of the phenomenon. We additionally incorporate spatial sensing by introducing an auxiliary field which depicts the polymerization of the region of the cell facing the highest concentration of the chemical attractant.
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA and Physics Department, Rutherford Building, 3600 Rue University, McGill University, Montréal, Québec, Canada H3A 2T8.
authors.forename: Sara
authors.initials: S
authors.lastname: Najem
authors.forename: Martin
authors.initials: M
authors.lastname: Grant
mesh_terms: D002633:Chemotaxis; D008954:Models, Biological; D009504:Neutrophils / Q000166:cytology*