title: The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): a meta-analysis.
abstract: OBJECTIVE
  To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis.
  
  
  METHODS
  Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and Ulcerative colitis (UC) were selected from electronic databases. A total of 17 studies including 4132 cases and 5109 controls were included in this meta-analysis which detected whether -1082G/A, -819C/T and -592C/A polymorphism were associated with CD or UC susceptibility.
  
  
  RESULTS
  The IL-10 -819C/T and -519C/A variant allele observed a significant association with UC (OR 1.16, 95%CI 1.03-1.31 and OR 1.19, 95%CI 1.03-1.38) not CD while there is no significant association between -1082G/A and UC or CD.
  
  
  CONCLUSIONS
  The IL-10 -819C/T and -592C/A polymorphisms contribute to susceptibility to UC, but IL-10 -1082G/A polymorphism neither associated with CD nor UC.
authors.affiliation: Department of Radiology, The Second Hospital of Anhui Medical University , Hefei, Anhui Province , China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Zou
authors.forename: Longsheng
authors.initials: L
authors.lastname: Wang
authors.forename: Xijun
authors.initials: X
authors.lastname: Gong
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Anhong
authors.initials: A
authors.lastname: Jiang
authors.forename: Suisheng
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044382:Population Groups / Q000235:genetics; D011401:Promoter Regions, Genetic; D017594:Publication Bias
chemical_list: D016753:Interleukin-10