title: Associations between TRAF1-C5 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study is to determine whether tumor necrosis factor receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in different populations.
  
  
  METHODS
  We conducted a meta-analysis of associations between the TRAF1-C5 polymorphisms and RA susceptibility.
  
  
  RESULTS
  A total of 24 comparative studies were included in this meta-analysis, including 22,682 patients with RA and 23,493 controls. The meta-analysis showed an association between the second allele of rs10818488 and RA in Europeans, but not in Asians (OR 1.229, 95% CI 1.094-1.381, p = 0.001; OR 1.060, 95% CI 0.930-1.335, p = 0.092). The meta-analysis also indicated an association between the second allele of rs3761847 and RA in Europeans, but not in Asians (OR 1.156, 95% CI 1.006-1.327, p = 0.041; OR 1.049, 95% CI 0.952-1.156, p = 0.333). The meta-analysis revealed an association between the second allele of the rs2900180 and rs10760130 polymorphisms and RA risk in Europeans (OR 1.224, 95% CI 1.065-1.405, p = 0.004; OR 1.072, 95% CI 1.002-1.147, p = 0.042).
  
  
  CONCLUSIONS
  This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul 136-705 , Korea .
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Bae
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D044466:Asian People; D003182:Complement C5 / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics*; D044465:White People
chemical_list: D003182:Complement C5; D047990:TNF Receptor-Associated Factor 1