title: Pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats.
abstract: In order to characterize the pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats, a reliable gradient HPLC-based method has been developed and validated. After p.o. administration of geniposide, the peak concentration of geniposide in plasma occurred at 1 h and plasma geniposide was eliminated nearly completely within 12 h. The AUC(0→∞) values of geniposide were 6.99 ± 1.27 h · µg/ml and 6.76 ± 1.23 h · µg/ml after i.v. administration of 10 mg/kg and p.o. administration of 100 mg/kg of geniposide, respectively. The absolute oral bioavailability (%F) of geniposide was calculated as 9.67%. After p.o. administration of geniposide, the AUC(0→4h) values in tissues were in the order of kidney > spleen > liver > heart > lung > brain. This study improved the understanding of the pharmacokinetics, bioavailability and tissue distribution of geniposide in rats and may provide a meaningful basis for clinical application of such a bioactive compound of herbal medicines.
authors.affiliation: College of Pharmacy, Taishan Medical University, Taian, China.
authors.forename: Fugang
authors.initials: F
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Cao
authors.forename: Jifu
authors.initials: J
authors.lastname: Hao
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001921:Brain / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D039823:Iridoids / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; C007835:geniposide
keywords: Gardenia jasminoides; bioavailability; geniposide; pharmacokinetics; tissue distribution