title: Genetic variations in IL6 and IL12B decreasing the risk for psoriasis.
abstract: BACKGROUND
  Psoriasis is a chronic inflammatory skin disorder. Recent studies associated a number of genetic variants to this immune-mediated pathology.
  
  
  OBJECTIVE
  This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
  
  
  METHODS
  We genotyped 67 psoriasis patients and 69 healthy subjects for polymorphisms of IL12B rs3212227 and rs6887695, IL23R rs11209026 and rs7530511, IL6 rs1800795 and for the presence of HLA-Cw6. The patients and controls were recruited from Dermatology Department, part of "Tor Vergata" Clinic, Rome. Demographic data of the control group matched those of psoriasis patients, with a female:male ratio of 2.55 and mean age of 45.5±12.2 years for patients and 44.8±11.7 years for controls.
  
  
  RESULTS
  The following genotypes were less frequent in patients: IL12B SNP rs6887695 CC (OR, 0.179; CI95% 0.046-0.699; p=0.01), IL6 SNP rs1800795 CG (OR, 0.367; CI95% 0.179-0.753; p=0.006) and IL6 SNP rs1800795 CC (OR, 0.069; CI95% 0.008-0.586; p=0.01). Also the HLA-Cw6 allele was rarely found in controls (OR, 0.459; CI95% 0.230-0.916; p=0.02). The multivariate analysis showed that the existence of at least one C allele in both IL12B SNP rs6887695 and IL6 SNP rs1800795 or the absence of HLA-Cw6 allele and at least one C allele in IL12B SNP rs6887695 or IL6 SNP rs1800795 is associated with a lower risk of psoriasis (OR, 0.185; CI95% 0.037-0.929; p=0.04). The presence of at least one C allele in both IL12B SNP rs6887695 and IL6 SNP rs1800795 and the absence of HLA-Cw6 allele decreased even further the risk of psoriasis (OR, 0.038; CI95% 0.006-0.244; p=0.001).
  
  
  CONCLUSIONS
  We report carriers of variations in the IL6, IL12B and absence of HLA-Cw6 as having decreased risk for psoriasis.
authors.affiliation: Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 6th Pasteur Street, 400349 Cluj-Napoca, Cluj, Romania. Electronic address: boca.andreea@umfcluj.ro.
authors.forename: Andreea Nicoleta
authors.initials: AN
authors.lastname: Boca
authors.forename: Marina
authors.initials: M
authors.lastname: Talamonti
authors.forename: Marco
authors.initials: M
authors.lastname: Galluzzo
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Botti
authors.forename: Stefan Cristian
authors.initials: SC
authors.lastname: Vesa
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Anca Dana
authors.initials: AD
authors.lastname: Buzoianu
authors.forename: Antonio
authors.initials: A
authors.lastname: Costanzo
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics; D012307:Risk Factors
chemical_list: D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; C515500:IL23R protein, human; D053762:Interleukin-12 Subunit p40; D015850:Interleukin-6; D018123:Receptors, Interleukin
keywords: HLA-Cw6; IL12B SNP; IL23R SNP; IL6 SNP; Psoriasis protective loci