title: [Effect of honey-toasting on the constituents and contents of aristolochic acid analogues in aristolochiae fructus].
abstract: OBJECTIVE
  To evaluate the degree of de-toxification of Aristolochiae Fructus by honey-toasting technology from chemical viewpoint.
  
  
  METHODS
  The contents of aristolochic acid analogues (AAs) in Aristolochiae Fructus and its honey-toasted product were determined by HPLC, and the degree of de-toxification was evaluated comprehensively.
  
  
  RESULTS
  After honey-toasted, the contents of AAs decreased to varying degrees, and some new compounds were found.
  
  
  CONCLUSIONS
  The constituents and contents of Aristolochiae Fructus change after honey-toasted, which indicate honey-toasting can reduce the toxicity of Aristolochiae Fructus.
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang 330004, China. lzh7226146@163.com
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Yang
authors.forename: Wu-Liang
authors.initials: WL
authors.lastname: Yang
authors.forename: Hai-Fang
authors.initials: HF
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Jin-Bin
authors.initials: JB
authors.lastname: Yuan
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Yan
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Luo
mesh_terms: D030022:Aristolochia / Q000737:chemistry*; D034341:Aristolochic Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry*; D006722:Honey; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical
chemical_list: D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I