title: Identifiability of subgroup causal effects in randomized experiments with nonignorable missing covariates.
abstract: Although randomized experiments are widely regarded as the gold standard for estimating causal effects, missing data of the pretreatment covariates makes it challenging to estimate the subgroup causal effects. When the missing data mechanism of the covariates is nonignorable, the parameters of interest are generally not pointly identifiable, and we can only get bounds for the parameters of interest, which may be too wide for practical use. In some real cases, we have prior knowledge that some restrictions may be plausible. We show the identifiability of the causal effects and joint distributions for four interpretable missing data mechanisms and evaluate the performance of the statistical inference via simulation studies. One application of our methods to a real data set from a randomized clinical trial shows that one of the nonignorable missing data mechanisms fits better than the ignorable missing data mechanism, and the results conform to the study's original expert opinions. We also illustrate the potential applications of our methods to observational studies using a data set from a job-training program.
authors.affiliation: Department of Statistics, Harvard University, Science Center, One Oxford Street, Cambridge, MA 02138, U.S.A.
authors.forename: Peng
authors.initials: P
authors.lastname: Ding
authors.forename: Zhi
authors.initials: Z
authors.lastname: Geng
mesh_terms: D003198:Computer Simulation; D017147:Defibrillators, Implantable; D004558:Electric Stimulation / Q000379:methods; D006801:Humans; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D014693:Ventricular Fibrillation / Q000628:therapy
keywords: bound; causal inference; expert opinion; missing data; sensitivity analysis