title: Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks.
abstract: A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
authors.affiliation: Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. a.d.burrows@bath.ac.uk m.f.mahon@bath.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Burrows
authors.forename: Monika
authors.initials: M
authors.lastname: Jurcic
authors.forename: Luke L
authors.initials: LL
authors.lastname: Keenan
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Lane
authors.forename: Mary F
authors.initials: MF
authors.lastname: Mahon
authors.forename: Mark R
authors.initials: MR
authors.lastname: Warren
authors.forename: Harriott
authors.initials: H
authors.lastname: Nowell
authors.forename: Michael
authors.initials: M
authors.lastname: Paradowski
authors.forename: John
authors.initials: J
authors.lastname: Spencer
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D000077543:Deferiprone; D003692:Delayed-Action Preparations / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000008:administration & dosage* / Q000737:chemistry; D008958:Models, Molecular; D011728:Pyridones / Q000008:administration & dosage* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D003692:Delayed-Action Preparations; D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D015032:Zinc