title: Canalicular adenoma--search for the cell of origin: ultrastructural and immunohistochemical analysis of 7 cases and review of the literature.
abstract: Canalicular adenoma (CA) is a rare, benign epithelial neoplasm of the salivary glands. Historically considered to be a variant of basal cell adenoma, this "monomorphic" adenoma has a distinct clinical, morphologic, and immunohistochemical profile. The putative cell of origin remains a topic of debate. A combination of morphology, immunohistochemistry, and ultrastructural analyses have been employed to determine histogenesis, but the interpretations of these studies have implicated multiple different cell types along the salivary gland duct as the cell of origin. The authors sought to further characterize CA using electron microscopy, immunohistochemistry, and special and immuno-stains on 7 cases. Their morphologic, immunohistochemical, and ultrastructural findings support a cell of origin demonstrating features of both the intercalated duct cells and the striated duct luminal epithelial cells.
authors.affiliation: Department of Pathology, University of Maryland Medical Center , Baltimore, Maryland , USA and.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Huebner
authors.forename: Hussain
authors.initials: H
authors.lastname: Almubarak
authors.forename: Cinthia B
authors.initials: CB
authors.lastname: Drachenberg
authors.forename: John C
authors.initials: JC
authors.lastname: Papadimitriou
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D014408:Biomarkers, Tumor