title: Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy.
abstract: We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. During the period of the hypothalamic-pituitary-adrenal system hyporeactivity, the pain response in the formalin test was associated with stress-related corticosterone variations. Maternal buspirone normalized the pain reaction in prenatally stressed rats during all periods of the formalin test and modified the dynamics of the corticosterone response. In 1 day after the formalin test, the basal level of this hormone in blood plasma remained increased. Maternal buspirone increased the resistance of the nociceptive and stress-systems to inflammatory-induced pain response in prenatally stressed rats.
authors.affiliation: Laboratory of Nervous System Ontogeny, Laboratory of Experimental Endocrinolgy, I. P. Pavlov Institute of Physiology, Russian Academy of Science, St. Petersburg. Russia. irinabutkevich@yandex.ru.
authors.forename: I P
authors.initials: IP
authors.lastname: Butkevich
authors.forename: V A
authors.initials: VA
authors.lastname: Mikhailenko
authors.forename: G V
authors.initials: GV
authors.lastname: Makukhina
authors.forename: T R
authors.initials: TR
authors.lastname: Bagaeva
authors.forename: Yu A
authors.initials: YA
authors.lastname: Stolyarova
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002065:Buspirone / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D005260:Female; D007249:Inflammation / Q000378:metabolism; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D058825:Serotonin 5-HT1 Receptor Agonists / Q000494:pharmacology*; D013315:Stress, Psychological
chemical_list: D058825:Serotonin 5-HT1 Receptor Agonists; D002065:Buspirone; D003345:Corticosterone