title: Striae distensae: a comprehensive review and evidence-based evaluation of prophylaxis and treatment.
abstract: Striae distensae are an extremely common, therapeutically challenging form of dermal scarring. Risk factors have been reported but much remains to be understood about their epidemiology, diagnosis and treatment. Up-to-date knowledge of the scientific research and the evidence behind both preventative and therapeutic agents are vital in order to understand striae and to offer patients the best therapeutic alternatives. We present a clinical review of the current literature concerning striae distensae and their prevention and treatment. A systematic review of the literature was undertaken using Medline, Embase and Google Scholar. Articles in English, Spanish, Portuguese, Turkish and French were included. Striae distensae occur in pregnancy, puberty and obesity as well as in numerous medical conditions and following therapeutic interventions. Proposed aetiological mechanisms relate to hormones, physical stretch and structural alterations to the integument. Assessment methods include subjective visual scoring and various imaging modalities. Treatments that we have evaluated include topical agents, used prophylactically or therapeutically, as well as light and laser therapies, which have shown improvements in the appearance of striae. Few high level evidence based medicine randomized controlled trials evaluating treatments for striae distensae exist. Topical therapeutic agents appear to lack efficacy in the prevention of striae distensae.
authors.affiliation: Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, U.K; Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, University of Manchester, Manchester, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Al-Himdani
authors.forename: S
authors.initials: S
authors.lastname: Ud-Din
authors.forename: S
authors.initials: S
authors.lastname: Gilmore
authors.forename: A
authors.initials: A
authors.lastname: Bayat
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D017115:Catheter Ablation / Q000379:methods; D003646:Debridement / Q000379:methods; D003879:Dermatologic Agents / Q000627:therapeutic use; D015444:Exercise / Q000502:physiology; D005260:Female; D006128:Growth / Q000502:physiology; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D008297:Male; D009765:Obesity / Q000150:complications; D010789:Phototherapy / Q000379:methods; D010808:Physical Examination / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control / Q000628:therapy; D012307:Risk Factors; D057896:Striae Distensae / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D015430:Weight Gain / Q000502:physiology
chemical_list: D003879:Dermatologic Agents