title: Withanolide-based steroids from the cultured soft coral Sinularia brassica.
abstract: Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of cancer cell lines also were determined.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
authors.forename: Chiung-Yao
authors.initials: CY
authors.lastname: Huang
authors.forename: Chih-Chuang
authors.initials: CC
authors.lastname: Liaw
authors.forename: Bo-Wei
authors.initials: BW
authors.lastname: Chen
authors.forename: Pei-Chin
authors.initials: PC
authors.lastname: Chen
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020014:K562 Cells; D007941:Leukemia P388; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D054358:Withanolides