title: Effect of Xinjikang on left ventricular hypertrophy remodeling in hypertensive rats.
abstract: OBJECTIVE
  To investigate the effects of Xinjikang on the left ventricular hypertrophy remodeling and myocardial activity in hypertension.
  
  
  METHODS
  Sixty Wistar rats were randomly divided into four groups. The pressure-loaded left ventricular hypertrophy model was established with abdominal aorta ligation method. Rats in A and B groups were intragastrically administered with physiological saline, while C and D groups were administered with Xinjikang and metoprolol, respectively. The changes in blood pressure, E/A ratio, myocardial pathological morphology, myocardial lipoperoxides and superoxide dismustase activity in four groups were observed and compared before and after treatment.
  
  
  RESULTS
  There were statistically significant differences in E/A ratio between C group after treatment and model group (P<0.05), while no difference was observed between A and D groups (P>0.05); after treatment the myocardial lipoperoxides and superoxide dismustase contents in C and D groups were improved significantly compared with model group (P<0.05).
  
  
  CONCLUSIONS
  Xinjikang can improve myocardial injury, restore myocardial parenchyma and myocardial interstitial remodeling functions in hypertensive rats with the left ventricular hypertrophy.
authors.affiliation: Yuhuangding Hospital of Yantai, Yantai 264000, Shandong Province, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Liu
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lin
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Zhou
authors.forename: Guo-Zhen
authors.initials: GZ
authors.lastname: Chen
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Cai
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology / Q000627:therapeutic use; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D008790:Metoprolol
keywords: Hypertension; Left ventricular hypertrophy; Rats; Xinjikang