title: Meglumine: A novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4H-pyrans.
abstract: An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatin derivatives, and acenaphthenequinone are condensed with enolizable C-H activated compounds and alkylmalonates to give the desired products in high to excellent yields. This methodology provides an alternative approach for rapid access to construct a diversity-oriented library of 4H-pyrans.
authors.affiliation: College of Chemistry & Material Science, Hebei Normal University , Shijiazhuang 050024, China.
authors.forename: Rui-Yun
authors.initials: RY
authors.lastname: Guo
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: An
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Mo
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Wang
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Liu
authors.forename: Shu-Xia
authors.initials: SX
authors.lastname: Wang
authors.forename: Zhan-Hui
authors.initials: ZH
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008536:Meglumine / Q000737:chemistry*; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011714:Pyrans; D008536:Meglumine