title: Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients.
abstract: To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold change=0.31) as compared to healthy subjects (fold change=0.86). It has been reported that in MCI there is an increase of BDNF serum levels, and our findings could indicate a positive effect of CT in restoring pre-disease levels of expression.
authors.affiliation: 1 Center for Neurobiology of Aging , INRCA IRCCS, Ancona, Italy .
authors.forename: Tiziana
authors.initials: T
authors.lastname: Casoli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Giuli
authors.forename: Marta
authors.initials: M
authors.lastname: Balietti
authors.forename: Belinda
authors.initials: B
authors.lastname: Giorgetti
authors.forename: Moreno
authors.initials: M
authors.lastname: Solazzi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D009483:Neuropsychological Tests
chemical_list: D019208:Brain-Derived Neurotrophic Factor