title: Sage in vitro cultures: a promising tool for the production of bioactive terpenes and phenolic substances.
abstract: Extracts of Salvia species are used in traditional medicine to treat various diseases. The economic importance of this genus has increased in recent years due to evidence that some of its secondary metabolites have valuable pharmaceutical and nutraceutical properties.The bioactivity of sage extracts is mainly due to their content of terpenes and polyphenols. The increasing demand for sage products combined with environmental, ecological and climatic limitations on the production of sage metabolites from field-grown plants have led to extensive investigations into biotechnological approaches for the production of Salvia phytochemicals. The purpose of this review is to evaluate recent progress in investigations of sage in vitro systems as tools for producing important terpenoids and polyphenols and in development of methods for manipulating regulatory processes to enhance secondary metabolite production in such systems.
authors.affiliation: Laboratory of Applied Biotechnologies, Department of Industrial Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000, Plovdiv, Bulgaria.
authors.forename: Andrey
authors.initials: A
authors.lastname: Marchev
authors.forename: Christiane
authors.initials: C
authors.lastname: Haas
authors.forename: Sibylle
authors.initials: S
authors.lastname: Schulz
authors.forename: Vasil
authors.initials: V
authors.lastname: Georgiev
authors.forename: Juliane
authors.initials: J
authors.lastname: Steingroewer
authors.forename: Thomas
authors.initials: T
authors.lastname: Bley
authors.forename: Atanas
authors.initials: A
authors.lastname: Pavlov
mesh_terms: D001688:Biological Products / Q000302:isolation & purification / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D018929:Cell Culture Techniques / Q000379:methods; D010636:Phenols / Q000302:isolation & purification / Q000378:metabolism*; D027544:Salvia / Q000378:metabolism*; D013729:Terpenes / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D001688:Biological Products; D010636:Phenols; D013729:Terpenes