title: Neonatal exposure to sevoflurane causes significant suppression of hippocampal long-term potentiation in postgrowth rats.
abstract: BACKGROUND
  The inhaled anesthetic sevoflurane is commonly used for neonates in the clinical setting. Recent studies have indicated that exposure of neonatal rodents to sevoflurane causes acute widespread neurodegeneration and long-lasting neurocognitive dysfunction. Although acute toxic effects of sevoflurane on cellular viability in the hippocampus have been reported in some studies, little is known about the effects of neonatal sevoflurane exposure on long-term hippocampal synaptic plasticity, which has been implicated in the processes of learning and memory formation. Our study is the first to examine the long-term electrophysiological impact of neonatal exposure to a clinically relevant concentration of sevoflurane.
  
  
  METHODS
  On postnatal day 7, rats were exposed to sevoflurane (1% or 2% for 2 hours) with oxygen. To eliminate the influence of blood gas abnormalities caused by sevoflurane-induced respiratory suppression, a group of rats were exposed to a high concentration of carbon dioxide (8% for 2 hours) to duplicate respiratory disturbances caused by 2% sevoflurane exposure.
  
  
  RESULTS
  Exposure of neonatal rats to 2% sevoflurane for 2 hours caused significant suppression of long-term potentiation (LTP) induction in the postgrowth period. There was no significant difference between the control group and the CO2-exposed group in LTP induction, indicating that sevoflurane-induced LTP suppression was not caused by blood gas abnormalities.
  
  
  CONCLUSIONS
  Our present findings indicate that neonatal exposure to sevoflurane at a higher concentration can cause alterations in the hippocampal synaptic plasticity that persists into adulthood.
authors.affiliation: From the *Department of Anesthesiology and Critical Care Medicine and †Division of Clinical Trial Management, Center for Translational Research, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Kato
authors.forename: Kaori
authors.initials: K
authors.lastname: Tachibana
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishimoto
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Uchida
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ito
authors.forename: Kenkichi
authors.initials: K
authors.lastname: Tsuruga
authors.forename: Koichi
authors.initials: K
authors.lastname: Takita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000367:Age Factors; D018685:Anesthetics, Inhalation / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D006624:Hippocampus / Q000187:drug effects* / Q000254:growth & development / Q000503:physiopathology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D013569:Synapses / Q000187:drug effects*; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane