title: SENSASS NMR: New NMR techniques for enhancing the sensitivity and the spectral resolution of polymer supported chemicals.
abstract: The use of polyethylene glycols (PEGs) as organic polymer soluble supports for synthesis has been receiving growing interest. The main advantages of using PEGs as support are related to their non-toxicity, their commercial availability and their solubility properties allowing easy recovery and analysis of compounds linked to the polymer. The NMR characterization of PEG-branched products could however be difficult due to the presence of huge signals of the polymeric support. In order to overcome this problem, we developed new NMR experiments named SENSitivity increAsed and resolution enhanced by Signal Suppression or SENSASS NMR. These experiments implement either semi-selective pulses or Water Gate sequences for reducing signals of the polymer as well as fast pulsing techniques optimizing the recycling delay for enhancing the sensitivity of signals. They have been successfully implemented in classical NMR characterization experiments namely, COSY, HSQC and HMBC experiments.
authors.affiliation: Université Paris-Sud, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe de Chimie des Procédés et des Substances Naturelles, CNRS UMR 8182, 15, rue Georges Clemenceau, bât 410, 91405 Orsay Cedex, France.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Prosa
authors.affiliation: Université Paris-Sud, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe de Chimie des Procédés et des Substances Naturelles, CNRS UMR 8182, 15, rue Georges Clemenceau, bât 410, 91405 Orsay Cedex, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Scherrmann
authors.affiliation: Université Paris-Sud, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe de RMN en Milieu Orienté, CNRS UMR 8182, 15, rue Georges Clemenceau, bât 410, 91405 Orsay Cedex, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Merlet
authors.affiliation: Université Paris-Sud, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Equipe de RMN en Milieu Orienté, CNRS UMR 8182, 15, rue Georges Clemenceau, bât 410, 91405 Orsay Cedex, France. Electronic address: jonathan.farjon@u-psud.fr.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Farjon
keywords: Fast repetition techniques; NMR; PEG-branched chemicals; Signal Suppression methods; Supported syntheses