title: [Relation between uric acid and coronary artery calcification:a community-based cross-sectional survey among Beijing natural population].
abstract: OBJECTIVE
  To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.
  
  
  METHODS
  From April to July 2012, 903 subjects from the natural population(aged 37-76 years for men, aged 42-76 years for women)in Xishan community, Beijing, were selected to accept a survey on the risk factors of cardiovascular. Blood tests and CT coronary artery calcium scans were carried out.
  
  
  RESULTS
  At the 1 Quartile(1 Q), 2 to 3 Quartile(2-3 Q)and 4 Quartile(4 Q)of uric acid levels, the prevalence rates of coronary artery calcium were 37.2% , 45.5% , 60.6% (P<0.001) and the coronary artery calcium scores were (109.7±333.1)AU, (133.9±356.9)AU, (200.8±459.4) AU (P < 0.001)respectively. Data from the univariate logistic regression analysis showed that with the increase of uric acid, the prevalence rates of coronary artery calcium also increased(OR2-3Q = 1.41, 95% CI:1.02-1.95, P = 0.040; OR4Q = 2.60, 95% CI:1.78-3.80, P < 0.001). However, the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis(OR2-3Q = 0.92, 95% CI: 0.60-1.43, P = 0.713;OR4Q = 1.38, 95% CI:0.80-2.39, P = 0.247).
  
  
  CONCLUSIONS
  Uric acid did not seem to be an independent risk factor for coronary artery calcium, although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.
authors.affiliation: Department of Radiology, State Key Laboratory of Cardiovascular Disease,Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Cao
authors.forename: Bin
authors.initials: B
authors.lastname: LV
authors.forename: Xiong-biao
authors.initials: XB
authors.lastname: Chen
authors.forename: Jin-guo
authors.initials: JG
authors.lastname: Lu
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Hou
authors.forename: Xiang
authors.initials: X
authors.lastname: Tang
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Shi-liang
authors.initials: SL
authors.lastname: Jiang
authors.forename: Lian-cheng
authors.initials: LC
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Dong-feng
authors.initials: DF
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D061205:Vascular Calcification / Q000453:epidemiology*
chemical_list: D014527:Uric Acid