title: New therapeutic strategies for squamous cell cancer and adenocarcinoma.
abstract: This paper presents commentaries on neoadjuvant treatment esophagectomy; the prognostic and predictive effects of single nucleotide polymorphisms (SNP) in the multimodality therapy of esophageal cancer; optimal preoperative treatment prior to surgery for esophageal cancer; a possible role for trastuzumab in treating esophageal adenocarcinoma or any esophageal dysplasia/intra-epithelial neoplasia; surgery after chemoradiation in resectable esophageal cancer; whether para-aortic lymph node dissection should be performed in esophagogastric junction (EGJ) tumors; and transhiatal esophagectomy in treatment of the esophageal cancer.
authors.affiliation: Department of Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Bas P L
authors.initials: BPL
authors.lastname: Wijnhoven
authors.affiliation: Department of Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Eelke L A
authors.initials: ELA
authors.lastname: Toxopeus
authors.affiliation: Department of General, Visceral and Pediatric Surgery, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vallböhmer
authors.affiliation: Department of General, Visceral and Pediatric Surgery, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Wolfram T
authors.initials: WT
authors.lastname: Knoefel
authors.affiliation: Jersey Shore University Medical Center, Neptune, New Jersey.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Krasna
authors.affiliation: Division of Hematology - Oncology, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Perez
authors.affiliation: Departments of Surgery and Radiotherapy, University Medical Center, Utrecht, The Netherlands.
authors.forename: Peter S N
authors.initials: PSN
authors.lastname: van Rossum
authors.affiliation: Departments of Surgery and Radiotherapy, University Medical Center, Utrecht, The Netherlands.
authors.forename: Jelle P
authors.initials: JP
authors.lastname: Ruurda
authors.affiliation: Departments of Surgery and Radiotherapy, University Medical Center, Utrecht, The Netherlands.
authors.forename: Richard
authors.initials: R
authors.lastname: van Hillegersberg
authors.affiliation: Department of Surgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Marc
authors.initials: M
authors.lastname: Schiesser
authors.affiliation: Department of Surgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Schneider
authors.affiliation: FMUSP and Nucleus of General and Specialized Surgery, Sao Paulo, Brazil.
authors.forename: Valter Nilton
authors.initials: VN
authors.lastname: Felix
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D016629:Esophagectomy; D004947:Esophagus / Q000601:surgery*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016896:Treatment Outcome
keywords: HER2; SNPs; neoadjuvant chemoradiation; transhiatal esophagectomy; transthoracic esophagectomy; trimodality