title: Effect of heparin coating of a foldable intraocular lens on inflammation and capsular bag performance after cataract surgery.
abstract: OBJECTIVE
  To evaluate the effect of a heparin-coated foldable intraocular lens (IOL) on postoperative flare in high-risk patients.
  
  
  METHODS
  Vienna Institute for Research in Ocular Surgery, Department of Ophthalmology, Hanusch Hospital, Vienna, Austria.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  This study included patients with diabetes mellitus (DM), pseudoexfoliation syndrome (PXF), or both scheduled for cataract surgery in both eyes. One eye received a coated IOL (Polylens EC-1YH PAL) and the other eye, an uncoated control IOL (Polylens EC-1Y PAL). Aqueous flare measurements were taken using a laser flare meter (FM-600, Kowa) preoperatively and 1 hour, 1 day, 3 weeks, and 3 months postoperatively. Visual acuity and anterior (ACO) and posterior (PCO) capsule opacification were assessed, and IOL centration and tilt were measured with a Purkinje meter.
  
  
  RESULTS
  Eighty eyes of 40 patients were included in the study; 64 eyes of 32 patients completed the study. The mean flare values (photons/ms) preoperatively and 1 hour, 1 day, 3 weeks, and 3 months postoperatively were 6.98 ± 3.71 (SD), 19.14 ± 18.90, 16.62 ± 25.33, 10.33 ± 9.70, 8.74 ± 4.64, respectively, with the coated IOL and 8.65 ± 5.73, 22.08 ± 16.23, 13.44 ± 13.71, 7.50 ± 4.11, and 7.03 ± 3.70, respectively, with the control IOL. No significant differences were found in flare, visual acuity, ACO, PCO, tilt, or centration between the coated IOL and the control IOL at any timepoint.
  
  
  CONCLUSIONS
  No significant differences in flare or capsule performance were found between the coated IOL and control IOL.
authors.affiliation: From the Vienna Institute for Research in Ocular Surgery (Maedel, Hirnschall, Chen, Findl), A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria; Moorfields Eye Hospital NHS Foundation Trust (Hirnschall, Findl), London, United Kingdom.
authors.forename: Sophie
authors.initials: S
authors.lastname: Maedel
authors.forename: Nino
authors.initials: N
authors.lastname: Hirnschall
authors.forename: Yen-An
authors.initials: YA
authors.lastname: Chen
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000166:cytology; D020099:Coated Materials, Biocompatible; D004311:Double-Blind Method; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007903:Lens Capsule, Crystalline / Q000503:physiopathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D014606:Uveitis, Anterior / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D005343:Fibrinolytic Agents; D006493:Heparin