title: 1H and 13C NMR investigation of 20-hydroxyecdysone dioxolane derivatives, a novel group of MDR modulator agents.
abstract: The synthesis, structure elucidation and the complete (1)H and (13)C signal assignment of a series of dioxolane derivatives of 20-hydroxyecdysone, synthesized as novel modulators of multidrug resistance, are presented. The structures and NMR signal assignment were established by comprehensive one-dimensional and two-dimensional NMR spectroscopy supported by mass spectrometry.
authors.affiliation: Ubichem Research Ltd., Illatos út 33, H-1097, Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Balázs
authors.forename: Attila
authors.initials: A
authors.lastname: Hunyadi
authors.forename: József
authors.initials: J
authors.lastname: Csábi
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Jedlinszki
authors.forename: Ana
authors.initials: A
authors.lastname: Martins
authors.forename: András
authors.initials: A
authors.lastname: Simon
authors.forename: Gábor
authors.initials: G
authors.lastname: Tóth
mesh_terms: D002247:Carbon Isotopes; D034821:Commelinaceae / Q000737:chemistry*; D004148:Dioxolanes / Q000138:chemical synthesis / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D004441:Ecdysterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D011522:Protons
chemical_list: C000589099:20-hydroxyecdysone dioxolane; D002247:Carbon Isotopes; D004148:Dioxolanes; D011522:Protons; D004441:Ecdysterone
keywords: 13C NMR; 1H NMR; 20-hydroxyecdysone dioxolanes; P-glycoprotein; antitumor agents; stereochemistry