title: EGFR and EGFRvIII in glioblastoma: partners in crime.
abstract: EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis, but the underlying mechanisms have remained elusive. In this issue of Cancer Cell, Weiss and colleagues implicate phosphorylation of EGFRvIII by EGFR and the consequent phosphorylation of STAT3 as a signaling axis that drives transformation in glioblastoma.
authors.affiliation: Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5S 2J7, Canada.
authors.forename: Gelareh
authors.initials: G
authors.lastname: Zadeh
authors.forename: Krishna P L
authors.initials: KP
authors.lastname: Bhat
authors.forename: Kenneth
authors.initials: K
authors.lastname: Aldape
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D050799:STAT5 Transcription Factor / Q000378:metabolism*
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; C410723:epidermal growth factor receptor VIII; C512478:EGFR protein, human; D066246:ErbB Receptors