title: Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3.
abstract: Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.
authors.affiliation: Institute for Advanced Study at the Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.org.chemie.tu-muenchen.de.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Neubauer
authors.forename: Florian
authors.initials: F
authors.lastname: Rechenmacher
authors.forename: Ambros J
authors.initials: AJ
authors.lastname: Beer
authors.forename: Flavio
authors.initials: F
authors.lastname: Curnis
authors.forename: Karolin
authors.initials: K
authors.lastname: Pohle
authors.forename: Calogero
authors.initials: C
authors.lastname: D'Alessandria
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Wester
authors.forename: Ute
authors.initials: U
authors.lastname: Reuning
authors.forename: Angelo
authors.initials: A
authors.lastname: Corti
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaiger
authors.forename: Horst
authors.initials: H
authors.lastname: Kessler
mesh_terms: D043924:Angiogenesis Modulating Agents; D000818:Animals; D006801:Humans; D039081:Integrin alpha5beta1 / Q000037:antagonists & inhibitors*; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors*; D051379:Mice; D057786:Peptidomimetics; D049268:Positron-Emission Tomography / Q000379:methods*; D051381:Rats
chemical_list: D043924:Angiogenesis Modulating Agents; D039081:Integrin alpha5beta1; D039302:Integrin alphaVbeta3; D057786:Peptidomimetics
keywords: RGD sequence; angiogenesis; integrins; peptidomimetics; positron emission tomography