title: Neurologic toxicity of lidocaine during awake intubation in a patient with tongue base abscess. Case report.
abstract: Lidocaine is commonly used for topical anesthesia of the upper airway in patient with anticipated difficult tracheal intubation undergoing awake fiberoptic intubation. Lidocaine toxicity is dose related and proportional to its plasma level. Although neurologic toxicity has been frequently observed with intravenous use, it has also been reported for topical use. We report on a case of a patient with base tongue abscess who developed sudden seizures and coma during application of topical anesthesia with lidocaine for awake fiberoptic intubation. The presence of a deep neck infection that causes hyperemia and edema of the pharyngolaryngeal mucosa may enhance transmucosal systemic absorption of local anesthetic. Moreover, conditions such as hypercarbia, dysphagia, or hepatic diseases are known to facilitate onset of lidocaine neurologic toxicity with serum concentration lower than normal. These findings should be kept in mind before administering topical anesthesia of the upper airway. In the presence of any of these conditions above, either the total dose of local anesthetic or its concentration should be reduced as much as possible.
authors.affiliation: Otolaryngology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy. Electronic address: davide.giordano@asmn.re.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Giordano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Panini
authors.forename: Carmine
authors.initials: C
authors.lastname: Pernice
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Raso
authors.forename: Verter
authors.initials: V
authors.lastname: Barbieri
mesh_terms: D000038:Abscess / Q000000981:diagnostic imaging / Q000601:surgery*; D000779:Anesthetics, Local / Q000009:adverse effects*; D005336:Fiber Optic Technology; D006801:Humans; D007441:Intubation, Gastrointestinal / Q000379:methods*; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014060:Tongue Diseases / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine