title: Multiple sclerosis and herpesvirus interaction.
abstract: Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions.
authors.affiliation: Irmandade da Santa Casa de Misericórdia de São Paulo, São PauloSP, Brasil.
authors.forename: Guilherme Sciascia do
authors.initials: GS
authors.lastname: Olival
authors.forename: Bruna Mendonça
authors.initials: BM
authors.lastname: Lima
authors.forename: Laura M
authors.initials: LM
authors.lastname: Sumita
authors.forename: Vitor
authors.initials: V
authors.lastname: Serafim
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Fink
authors.forename: Luis Henrique
authors.initials: LH
authors.lastname: Nali
authors.forename: Camila Malta
authors.initials: CM
authors.lastname: Romano
authors.forename: Rodrigo Barbosa
authors.initials: RB
authors.lastname: Thomaz
authors.forename: Vitor Breseghello
authors.initials: VB
authors.lastname: Cavenaghi
authors.forename: Charles Peter
authors.initials: CP
authors.lastname: Tilbery
authors.forename: Augusto Cesar
authors.initials: AC
authors.lastname: Penalva-de-Oliveira
mesh_terms: D006566:Herpesviridae Infections / Q000821:virology*; D006801:Humans; D009103:Multiple Sclerosis / Q000821:virology*