title: Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones.
abstract: The aim of the study was to assess the association of phthalate metabolites levels in urine with semen parameters (sperm concentration, motility, morphology, CASA parameters), sperm chromatin structure, sperm aneuploidy and reproductive hormones. The study population consisted of 269 men who were attending an infertility clinic and had normal semen concentration (20-300mln/ml) or slight oligozoospermia (15-20mln/ml). Participants were interviewed and provided a semen sample. The phthalate metabolites were analysed in the urine using a procedure based on the LC-MS/MS method. Urinary phthalate metabolites levels were significantly associated with a decrease in sperm motility (5OH MEHP, MEHP, MINP), CASA parameters (MBP), testosterone level (MEHP) and an increase sperm DNA damage (MBP) and sperm aneuploidy (MBzP, MBP, MEHP, MEP). In view of the importance of human reproductive health and the widespread usage of phthalates, it is important to further investigate these correlations.
authors.affiliation: Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 8 Teresy Street, 91-362 Lodz, Poland. Electronic address: joannaj@imp.lodz.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jurewicz
authors.forename: Michał
authors.initials: M
authors.lastname: Radwan
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sobala
authors.forename: Danuta
authors.initials: D
authors.lastname: Ligocka
authors.forename: Paweł
authors.initials: P
authors.lastname: Radwan
authors.forename: Michał
authors.initials: M
authors.lastname: Bochenek
authors.forename: Wanda
authors.initials: W
authors.lastname: Hawuła
authors.forename: Lucjusz
authors.initials: L
authors.lastname: Jakubowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Hanke
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002843:Chromatin / Q000378:metabolism; D004785:Environmental Pollutants / Q000652:urine*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008297:Male; D010795:Phthalic Acids / Q000652:urine*; D012661:Semen / Q000737:chemistry / Q000166:cytology; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000378:metabolism* / Q000473:pathology; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D002843:Chromatin; D004785:Environmental Pollutants; D010795:Phthalic Acids; D013739:Testosterone; D004958:Estradiol; C032279:phthalic acid; D005640:Follicle Stimulating Hormone
keywords: Exposure to phthalates; Semen quality; Sperm aneuploidy; Sperm chromatin structure