title: Gadolinium complex and phosphorescent probe-modified NaDyF4 nanorods for T1- and T2-weighted MRI/CT/phosphorescence multimodality imaging.
abstract: To compensate for the deficiencies of individual imaging modalities, lanthanide-based nanoparticles are ideal building blocks for multifunctional contrast agents. Herein, oleic acid-coated NaDyF4 nanorods (DyNPs) were synthesized by the hydrothermal method, and then coated with α-cyclodextrin (α-CD) and modified with gadolinium complex (Gd-DTPA) to obtain hydrophilic and functionalized nanoparticles (DyNPs-Gd). By loading the phosphorescent probe (iridium-complex) within the surface hydrophobic layer, the developed nanophosphors (DyNPs-Gd-Ir) could be further applied in phosphorescent cell labeling. The Dy in the host induces a high X-ray absorption ability for X-ray computed tomography (CT) and negative enhancement for T2-weighted magnetic resonance imaging (MRI), whereas positive contrast for T1-weighted MRI results from the Gd-DTPA. DyNPs-Gd-Ir has been successfully applied to T1- and T2-weighted MRI/CT in vivo. Toxicity studies demonstrated that DyNPs-Gd-Ir exhibited low toxicity to living systems. Therefore, DyNPs-Gd-Ir could be a platform for next-generation contrast agents for T1- and T2-weighted MRI/CT/phosphorescence multimodal imaging.
authors.affiliation: Department of Chemistry, Capital Normal University, No. 105 Xi San Huan Road, Beijing 100048, PR China. Electronic address: Jenniferjingzhou@gmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Lu
authors.forename: Guogang
authors.initials: G
authors.lastname: Shan
authors.forename: Sihui
authors.initials: S
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liao
mesh_terms: D000818:Animals; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D064593:Heterografts; D006801:Humans; D049449:Luminescence; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging; D043942:Nanotubes; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D005682:Gadolinium
keywords: CT; MRI; NaDyF(4); Nanorods; Phosphorescence imaging; T(1) and T(2)-weighted