title: Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients.
abstract: OBJECTIVE
  Susceptibility to psoriasis has been associated with the HLA-C*0602 allele, although it may be affected by other polymorphisms.
  
  
  METHODS
  We genotyped 142 patients and 160 healthy volunteers to evaluate the possible relationship between susceptibility to psoriasis and the HLA-C*0602 allele and polymorphisms in the TNF, IL12B, and IL23R genes.
  
  
  RESULTS
  The frequency of the wild-type TNF-238, TNF-308, and TNF-1031 genotypes was greater in patients with psoriasis than in healthy volunteers, although that of the mutant TNF-857 genotype was higher. The only difference between psoriasis and psoriatic arthritis was TNF-857. The frequency of the HLAC*0602 allele was higher in psoriatic patients than in healthy volunteers. No differences were observed for IL12B and IL23R. Multivariate logistic regression analysis only confirmed these associations for TNF-238, TNF-857, and HLA-C*0602.
  
  
  CONCLUSIONS
  Our results support an association between susceptibility to psoriasis and TNF polymorphisms in the Spanish population.
authors.affiliation: Clinical Pharmacology Service.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cabaleiro
authors.forename: Manuel
authors.initials: M
authors.lastname: Román
authors.forename: Elena
authors.initials: E
authors.lastname: Gallo
authors.forename: Dolores
authors.initials: D
authors.lastname: Ochoa
authors.forename: Fátima
authors.initials: F
authors.lastname: Tudelilla
authors.forename: María
authors.initials: M
authors.lastname: Talegón
authors.forename: Rocío
authors.initials: R
authors.lastname: Prieto-Pérez
authors.forename: Amaro
authors.initials: A
authors.lastname: García-Díez
authors.forename: Esteban
authors.initials: E
authors.lastname: Daudén
authors.forename: Francisco
authors.initials: F
authors.lastname: Abad-Santos
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D013030:Spain; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens; C491620:HLA-C*06:02 antigen; C500879:IL12B protein, human; C515500:IL23R protein, human; D053762:Interleukin-12 Subunit p40; D018123:Receptors, Interleukin; D014409:Tumor Necrosis Factor-alpha
keywords: IL12B; IL23R; psoriasis; single-nucleotide polymorphisms; tumour necrosis factor