title: Antibiotics from neglected bacterial sources.
abstract: The current crop of antibiotics in clinical use are either natural products or their derivatives. However, the rise of a multitude of different antibiotic resistant human pathogens has meant that new antibiotics are urgently needed. Unfortunately, the search for new antibiotics from traditional bacterial sources often results in a high rediscovery rate of known compounds and a low chance of identifying truly novel chemical entities. To overcome this, previously unexplored (or under investigated) bacterial sources are being tapped for their potential to produce novel compounds with new activities. Here, we review a number of antibiotic compounds identified from bacteria of the genera Burkholderia, Clostridium, Lysobacter, Pantoea and Xenorhabdus and describe the potential of organisms and their associated metabolites in future drug discovery efforts.
authors.affiliation: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, 07745 Jena, Germany.
authors.forename: Sacha J
authors.initials: SJ
authors.lastname: Pidot
authors.affiliation: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, 07745 Jena, Germany.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Coyne
authors.affiliation: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, 07745 Jena, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Kloss
authors.affiliation: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, 07745 Jena, Germany. Electronic address: christian.hertweck@hki-jena.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use; D019117:Burkholderia / Q000737:chemistry* / Q000235:genetics; D003013:Clostridium / Q000737:chemistry* / Q000235:genetics; D055808:Drug Discovery / Q000639:trends; D020563:Gammaproteobacteria / Q000737:chemistry* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D001688:Biological Products
keywords: Burkholderia; Clostridium; Genome mining; Lysobacter; Pantoea; Xenorhabdus