title: Antimycobacterial labdane diterpenes from Leucas stelligera.
abstract: Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1-4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1-4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02-9.80 μg/mL.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411008, India.
authors.forename: Roshan R
authors.initials: RR
authors.lastname: Kulkarni
authors.forename: Ketaki
authors.initials: K
authors.lastname: Shurpali
authors.forename: Vedavati G
authors.initials: VG
authors.lastname: Puranik
authors.forename: Dhiman
authors.initials: D
authors.lastname: Sarkar
authors.forename: Swati P
authors.initials: SP
authors.lastname: Joshi
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D056945:Hep G2 Cells; D006801:Humans; D007194:India; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes; D047309:Flavones; C577620:5,4'-dihydroxy-7,3'-dimethoxyflavone; C007054:chrysoeriol