title: Metabolic alteration in tumorigenesis.
abstract: Altered metabolism in cancer was first discovered by Otto Warburg early last century. Although the Warburg Effect has been widely used in tumor detection, relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades. Genetic studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate metabolism. One emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control.
authors.affiliation: Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical College; School of Life Sciences, Fudan University, Shanghai, 200032, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiong
authors.forename: KunLiang
authors.initials: K
authors.lastname: Guan
mesh_terms: D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism*; D049109:Cell Proliferation; D044127:Epigenesis, Genetic; D005649:Fumarate Hydratase / Q000235:genetics / Q000378:metabolism; D005977:Glutarates / Q000378:metabolism; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000235:genetics / Q000378:metabolism
chemical_list: D005977:Glutarates; D007656:Ketoglutaric Acids; C019417:alpha-hydroxyglutarate; D007521:Isocitrate Dehydrogenase; D013385:Succinate Dehydrogenase; D005649:Fumarate Hydratase