title: Effect of metabolic presbyacusis on cochlear responses: a simulation approach using a physiologically-based model.
abstract: In the presented model, electrical, acoustical, and mechanical elements of the cochlea are explicitly integrated into a signal transmission line where these elements convey physiological interpretations of the human cochlear structures. As a result, this physiologically-motivated model enables simulation of specific cochlear lesions such as presbyacusis. The hypothesis is that high-frequency hearing loss in older adults may be due to metabolic presbyacusis whereby age-related cellular/chemical degenerations in the lateral wall of the cochlea cause a reduction in the endocochlear potential. The simulations quantitatively confirm this hypothesis and emphasize that even if the outer and inner hair cells are totally active and intact, metabolic presbyacusis alone can significantly deteriorate the cochlear functionality. Specifically, in the model, as the endocochlear potential decreases, the transduction mechanism produces less receptor current such that there is a reduction in the battery of the somatic motor. This leads to a drastic decrease in cochlear amplification and frequency sensitivity, as well as changes in position-frequency map (tuning pattern) of the cochlea. In addition, the simulations show that the age-related reduction of the endocochlear potential significantly inhibits the firing rate of the auditory nerve which might contribute to the decline of temporal resolution in the aging auditory system.
authors.affiliation: Department of Clinical and Experimental Medicine, Division of Technical Audiology, Linköping University, 581 85 Linköping, Sweden.
authors.forename: Amin
authors.initials: A
authors.lastname: Saremi
authors.forename: Stefan
authors.initials: S
authors.lastname: Stenfelt
mesh_terms: D000200:Action Potentials; D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D003056:Cochlear Nerve / Q000378:metabolism / Q000503:physiopathology; D003198:Computer Simulation; D005071:Evoked Potentials; D006199:Hair Cells, Auditory, Inner / Q000378:metabolism / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000378:metabolism / Q000473:pathology; D006309:Hearing; D006801:Humans; D016014:Linear Models; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D017711:Nonlinear Dynamics; D011304:Presbycusis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure; D013997:Time Factors; D014732:Vibration