title: Spatiotemporal drug release visualized through a drug delivery system with tunable aggregation-induced emission.
abstract: Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety National Center for Nanoscience and Technology, No 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Xue
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Luru
authors.initials: L
authors.lastname: Dai
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Hao
authors.forename: Chunqiu
authors.initials: C
authors.lastname: Zhang
authors.forename: Shuaidong
authors.initials: S
authors.lastname: Huo
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Chen
authors.forename: Guozhang
authors.initials: G
authors.lastname: Zou
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004317:Doxorubicin
keywords: aggregation-induced emission; drug delivery system; nanoaggregation; self-indicating nanoparticles; spatiotemporal drug release