title: Rhodotorula minuta as onychomycosis agent in a Chinese patient: first report and literature review.
abstract: Onychomycosis is a common superficial fungal infection, which usually caused by dermatophytes, yeast and non-dermatophytic moulds. Recently, we isolated a Rhodotorula minuta isolate from a 15-year-old immunocompetent girl student in Hangzhou (China) that was identified using microscopy, culture morphology, histological diagnosis, API 20C AUX Yeast Identification Kit and sequencing of the Internal Transcribed Spacer region. In vitro, antifungal susceptibility tests showed that this yeast isolate was susceptible to low concentrations of amphotericin B, itraconazole, voriconazole and 5-flvoriconaz but that it appeared to be dose-dependent susceptible to fluconazole(MIC = 16 μg/ml). Furthermore, the effective result of therapy with itraconazole against R. minuta was consistent with that of susceptibility tests.
authors.affiliation: Shanghai Key Laboratory of Medical Molecular Mycology & PLA Key Laboratory of Fungal Disease, ChangZheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Hongduo
authors.initials: H
authors.lastname: Chen
authors.forename: Weihua
authors.initials: W
authors.lastname: Pan
authors.forename: Wanqing
authors.initials: W
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D044466:Asian People; D002681:China; D025141:Drug Resistance, Fungal; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D014009:Onychomycosis / Q000188:drug therapy* / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use; D012248:Rhodotorula / Q000187:drug effects / Q000302:isolation & purification*; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D065819:Voriconazole
keywords: ITS; Onychomycosis; PSO; Rhodotorula; Rhodotorula minuta