title: Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection.
abstract: Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P = 0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P = 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P = 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended.
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: M B
authors.initials: MB
authors.lastname: Isa
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: J V
authors.initials: JV
authors.lastname: Pavan
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Sicilia Don
authors.affiliation: Institute 'Sanatorio Allende',Córdoba,Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Grutadauria
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: L C
authors.initials: LC
authors.lastname: Martinez
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: M O
authors.initials: MO
authors.lastname: Giordano
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Masachessi
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: P A
authors.initials: PA
authors.lastname: Barril
authors.affiliation: Virology Institute 'Dr J. M. Vanella', School of Medical Sciences,National University of Córdoba,Córdoba,Argentina.
authors.forename: S V
authors.initials: SV
authors.lastname: Nates
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology*; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D008458:Measles Vaccine