title: Determinants of fat-soluble vitamin status in patients aged 65 years and over.
abstract: In the elderly, malnutrition is highly prevalent and a major contributor to increased morbidity and mortality. We aimed to evaluate the fat-soluble vitamin status and potential determinants in patients >65 years of age. Serum vitamins A, D and E were determined by liquid chromatography in 166 patients. Gender, age, season, hospitalization, nutritional markers (albumin and cholesterol), acute-phase reactants (ferritin and C-reactive protein) and renal function (creatinine and glomerular filtrate) were assessed as potential determinants. Prevalence of vitamin deficiency was highly variable, ranging from 0 (vitamin E/cholesterol ratio) to 94% (for vitamin D in hospitalized patients). Vitamin status did not differ according to gender, but age, season, hospitalization, a poor nutritional status and impaired renal function, and the presence of acute-phase response significantly affected serum levels of vitamin A, E and D. In conclusion, in subjects >65 years both demographic and clinical factors determined the fat-soluble vitamin status.
authors.affiliation: 1] Unidad de Vitaminas, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain [2] Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Granado-Lorencio
authors.forename: I
authors.initials: I
authors.lastname: Blanco-Navarro
authors.forename: B
authors.initials: B
authors.lastname: Pérez-Sacristán
authors.forename: I
authors.initials: I
authors.lastname: Millán
authors.forename: E
authors.initials: E
authors.lastname: Donoso-Navarro
authors.forename: R A
authors.initials: RA
authors.lastname: Silvestre-Mardomingo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D005919:Glomerular Filtration Rate; D006760:Hospitalization; D006801:Humans; D007668:Kidney / Q000502:physiology; D008297:Male; D009752:Nutritional Status; D012621:Seasons; D012709:Serum Albumin / Q000032:analysis; D012737:Sex Factors; D014801:Vitamin A / Q000097:blood*; D014807:Vitamin D / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
chemical_list: D012709:Serum Albumin; D014801:Vitamin A; D014807:Vitamin D; D014810:Vitamin E; D002097:C-Reactive Protein; D005293:Ferritins; D002784:Cholesterol; D003404:Creatinine