title: Poor wound healing after pial synangiosis in 2 children with moyamoya vasculopathy associated with neurofibromatosis type 1.
abstract: Wound healing is a key component of recovery for children with neurologic conditions undergoing neurosurgical procedures. Understanding factors that can impair wound healing aids in planning long-term clinical care. Children with neurofibromatosis type 1 are at risk for vasculopathies in the brain (including moyamoya vasculopathy) and in other organs, including the heart, lung, and skin. Neurofibromatosis 1 is caused by mutations in the gene for neurofibromin, a protein that plays a role in tissue maintenance and repair as well as tumor suppression. The authors report 2 children with neurofibromatosis 1-associated moyamoya vasculopathy who developed significant wound healing complications after pial synangiosis surgery. They discuss possible contributors to these complications, including the role of neurofibromin and the possibility of vasculopathy affecting the skin, and the implications of poor wound healing in pediatric neurology patients.
authors.affiliation: Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, IN, USA mgolomb@iupui.edu.
authors.forename: Meredith R
authors.initials: MR
authors.lastname: Golomb
authors.affiliation: Department of Neurosurgery, Division of Pediatric Neurosurgery, Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, IN, USA.
authors.forename: Jodi L
authors.initials: JL
authors.lastname: Smith
mesh_terms: D002548:Cerebral Revascularization / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009072:Moyamoya Disease / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D009456:Neurofibromatosis 1 / Q000150:complications / Q000503:physiopathology*; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D010841:Pia Mater / Q000098:blood supply* / Q000601:surgery; D011183:Postoperative Complications; D014945:Wound Healing
keywords: complications; dehiscence; moyamoya; neurofibromatosis; neurofibromin; vasculopathy; wound healing