title: Association of mitochondrial DNA displacement loop polymorphisms and aggressive periodontitis in a Chinese population: a pilot study.
abstract: To examine whether certain mitochondrial DNA (mtDNA) haplogroups and/or alterations affect susceptibility to aggressive periodontitis (AgP), we analyzed the mtDNA D-Loop region in a Han Chinese population. The mtDNA haplogroups were analyzed in 58 patients with AgP and 50 periodontally healthy controls. The frequency of haplogroups A in AgP group was significantly higher than that in the control group (p=0.007). Furthermore, the frequency of haplogroup D was higher in the control group than that in AgP group (p=0.007). The frequencies of D-Loop polymorphisms m.16126T>C, m.16290C>T and m.152 T> C were significantly higher in patients with AgP compared with controls (p=0.029, 0.014 and 0.022, respectively). Additionally, the frequencies of three other D-Loop polymorphisms, m.16223C>T m.489 T>C and m.515CA deletion (del) were significantly lower in patients with AgP compared with controls (p=0.042, 0.003 and 0.026, respectively). Our study showed for the first time, an association between AgP and mtDNA haplogroups. Haplogroups A was implicated as a risk factor for AgP, while haplogroups D exhibited a protective effect in this disease. These observations may provide a new perspective on the study of the pathogenesis of periodontitis.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology , Beijing , China.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Luan
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D004272:DNA, Mitochondrial / Q000145:classification / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010802:Phylogeny; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D011859:Radiography; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial
keywords: AgP; D-loop; haplogroup; hypervariable region; mtDNA