title: Serial sub-conjunctival 5-Fluorouracil for early recurrent anophthalmic contracted socket.
abstract: BACKGROUND
  To evaluate the effects and side-effects of serial sub-conjunctival injections of 5-fluorouracil (5-FU) in early postoperative period for recurrent anophthalmic contracted socket.
  
  
  METHODS
  Retrospective comparative case series at tertiary eye care centre including fifteen adult patients with features of postoperative recurrent socket contraction after buccal mucosal graft. Group A comprised eight patients treated with 10 mg weekly sub-conjunctival injection of 5-FU in the fornices. Group B comprised seven patients taken as control. Main outcome measures were: superior fornix depth (SFD), inferior fornix depth (IFD), and socket volume (SV) at 6 months follow up. Patients were re-evaluated clinically for recurrence at last follow-up.
  
  
  RESULTS
  The mean ± SD values in group A versus group B were as follows: 10 ± 1.6 mm vs 5.1 ± 0.9 mm (p < 0.005) for SFD, 6.7 ± 1.5 mm vs 3.5 ± 0.5 mm (p = 0.02) for IFD; and 2 ± 0.55 ml versus 0.27 ± 0.06 ml (p = 0.005) for SV at 6 months. There was significant improvement in depth of fornices and volume of socket in seven patients in group A. One patient in group A did not benefit from 5-FU treatment. The beneficial effects of 5-FU were observed when first injection was given within 4 weeks after socket reconstruction. There was no recurrence (in six cases) and no side-effects seen in group A at final follow-up of 18.2 (12-24) months.
  
  
  CONCLUSIONS
  Weekly injections of 5-FU are effective for stopping the progression of recurrent contracted socket following primary reconstructive surgery. It provides early rehabilitation, and avoids repetitive surgery.
authors.affiliation: Guru Nanak Eye Centre, Maulana Azad Medical College, 221, First floor, New Delhi, India, 11002, drskamal@gmail.com.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Kamal
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Ruchi
authors.initials: R
authors.lastname: Goel
authors.forename: Sonam Angmo
authors.initials: SA
authors.lastname: Bodh
mesh_terms: D000328:Adult; D000853:Anophthalmos / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D000963:Antimetabolites / Q000008:administration & dosage* / Q000009:adverse effects; D003228:Conjunctiva / Q000187:drug effects; D003286:Contracture / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D015353:Eye Enucleation; D005137:Eye, Artificial; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D056965:Injections, Intraocular; D009916:Orbital Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D020273:Orbital Implants; D011184:Postoperative Period; D019651:Plastic Surgery Procedures; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil