title: Improvement of dementia screening accuracy of mini-mental state examination by education-adjustment and supplementation of frontal assessment battery performance.
abstract: This study aimed to investigate whether the demographic variable-adjustment and supplementation of Frontal Assessment Battery (FAB) score can improve the screening ability of Mini-Mental State Examination (MMSE) for dementia and its subtypes. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer's disease [AD]; 139 non-Alzheimer's disease dementia [NAD]; and 15 mixed AD-NAD dementia) individuals living in the community were included. Education-adjusted MMSE (MMSE-edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. FAB-supplemented MMSE (MMSE-FAB) score had significantly better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. Additional supplementation of FAB to MMSE-edu further increased the ability for overall dementia or NAD screening, but not for AD screening. Further education adjustment of MMSE-FAB also improved its ability for overall dementia, AD, and NAD screening. These results strongly support the usefulness of education-adjustment and supplementation of frontal function assessment to improve screening performance of MMSE for dementia and its subtypes, NAD in particular.
authors.affiliation: Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
authors.forename: Jee Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Lee
authors.forename: Eun Hyun
authors.initials: EH
authors.lastname: Seo
authors.forename: Bo Kyung
authors.initials: BK
authors.lastname: Sohn
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Park
authors.forename: Il Han
authors.initials: IH
authors.lastname: Choo
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Youn
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.forename: Jong Inn
authors.initials: JI
authors.lastname: Woo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis; D019540:Area Under Curve; D003704:Dementia / Q000150:complications / Q000175:diagnosis*; D003710:Demography; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve
keywords: Dementia; Education; Frontal Assessment Battery; Mini-Mental State Examination; Screening Accuracy