title: The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
abstract: USP17 is a cell cycle regulated deubiquitinating enzyme that is highly expressed in tumor-derived cell lines and has an established role in cell proliferation and chemotaxis. This is the first study to examine the clinical significance of USP17 expression in non-small cell lung cancer (NSCLC). USP17 was overexpressed in both squamous and adenocarcinoma NSCLC tissue. Patients with USP17 positive tumors had significantly reduced recurrence-free survival than patients with USP17 negative tumors. Moreover, USP17 was more highly expressed in patients with recurrence of disease at distant sites, suggesting that USP17 levels may correlate with NSCLC distant metastases. Overall, these findings establish USP17 as a potentially valuable novel biomarker for metastatic lung cancer.
authors.affiliation: Centre for Infection and Immunity, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: Cheryl
authors.initials: C
authors.lastname: McFarlane
authors.forename: Suzanne
authors.initials: S
authors.lastname: McFarlane
authors.forename: Ian
authors.initials: I
authors.lastname: Paul
authors.forename: Kenneth
authors.initials: K
authors.lastname: Arthur
authors.forename: Michael
authors.initials: M
authors.lastname: Scheaff
authors.forename: Keith
authors.initials: K
authors.lastname: Kerr
authors.forename: Michael
authors.initials: M
authors.lastname: Stevenson
authors.forename: Dean A
authors.initials: DA
authors.lastname: Fennell
authors.forename: James A
authors.initials: JA
authors.lastname: Johnston
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000473:pathology; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D015331:Cohort Studies; D018572:Disease-Free Survival; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology; D016019:Survival Analysis; D054875:Ubiquitination
chemical_list: D014408:Biomarkers, Tumor; D010450:Endopeptidases; C484854:USP17L2 protein, human