title: Amphiphilic peptoid transporters--synthesis and evaluation.
abstract: Cell-penetrating peptoids are an important class of peptidomimetics, which can replace highly biodegradable cell penetrating peptides for enhanced drug delivery. Typically, they contain positively charged amino side chains which are synthesized via their protected analogues. To avoid the use of amine protecting groups a Click-chemistry based modular synthesis of novel hydrophilic as well as amphiphilic cell penetrating peptoids was developed to generate novel structures for drug delivery in cells.
authors.affiliation: Karlsruhe Institute of Technology, Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. braese@kit.edu.
authors.forename: Sidonie B L
authors.initials: SB
authors.lastname: Vollrath
authors.forename: Daniel
authors.initials: D
authors.lastname: Fürniss
authors.forename: Ute
authors.initials: U
authors.lastname: Schepers
authors.forename: Stefan
authors.initials: S
authors.lastname: Bräse
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D057930:Click Chemistry; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D034444:Peptoids / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D034444:Peptoids; D013501:Surface-Active Agents