title: Availability of polymeric nanoparticles for specific enhanced and targeted drug delivery.
abstract: Over the past 20-30 years there has been quite a number of studies interested in polymeric nanoparticle (PNP) systems as a pharmaceutical approach for poorly soluble drugs, peptide drugs, gene and antibodies. Now, the products based on the PNP technologies are used in the fields of medical science, pharmaceutical science, tissue engineering and clothing, food and housing. This review focuses attention on PNPs for specific enhanced and targeted drug delivery of therapeutic drugs including peptide drugs as well as drug delivery applications of such systems. Outcomes from recent studies on polymers, how to make PNPs, pharmacokinetics and pharmacodynamics of PNPs, and the release profiles from PNPs and related systems are also described, including their pharmacokinetics and pharmacodynamics, if available. In addition, the latest PNP trends and will be described.
authors.affiliation: Department of Pharmacokinetics, Doshisha Women's College of Liberal Arts, Faculty of Pharmaceutical Sciences, Kodo Kyotanabe 610-0395, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kiriyama
authors.forename: Katsumi
authors.initials: K
authors.lastname: Iga
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Shibata
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D010599:Pharmacokinetics; D011108:Polymers / Q000737:chemistry*; D034622:RNA Interference; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers