title: Polymeric nanoparticles: potent vectors for vaccine delivery targeting cancer and infectious diseases.
abstract: Nanocarriers with various compositions and biological properties have been extensively applied for in vitro/in vivo drug and gene delivery. The family of nanocarriers includes polymeric nanoparticles, lipid-based carriers (liposomes/micelles), dendrimers, carbon nanotubes, and gold nanoparticles (nanoshells/nanocages). Among different delivery systems, polymeric carriers have several properties such as: easy to synthesize, inexpensive, biocompatible, biodegradable, non-immunogenic, non-toxic, and water soluble. In addition, cationic polymers seem to produce more stable complexes led to a more protection during cellular trafficking than cationic lipids. Nanoparticles often show significant adjuvant effects in vaccine delivery since they may be easily taken up by antigen presenting cells (APCs). Natural polymers such as polysaccharides and synthetic polymers have demonstrated great potential to form vaccine nanoparticles. The development of new adjuvants or delivery systems for DNA and protein immunization is an expanding research field. This review describes polymeric carriers especially PLGA, chitosan, and PEI as vaccine delivery systems.
authors.affiliation: Department of Hepatitis and AIDs; Pasteur Institute of Iran; Tehran, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Bolhassani
authors.affiliation: Department of Hepatitis and AIDs; Pasteur Institute of Iran; Tehran, Iran; Department of genetics; Islamic Azad University; Tehran Medical Branch; Tehran, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Javanzad
authors.affiliation: Department of Nanobiotechnology; Faculty of Biological Sciences; Tarbiat Modares University; Tehran, Iran.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Saleh
authors.affiliation: Department of genetics; Islamic Azad University; Tehran Medical Branch; Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Department of Hepatitis and AIDs; Pasteur Institute of Iran; Tehran, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Aghasadeghi
authors.affiliation: Department of Hepatitis and AIDs; Pasteur Institute of Iran; Tehran, Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Sadat
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D003140:Communicable Disease Control; D004337:Drug Carriers / Q000008:administration & dosage*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000517:prevention & control*; D011108:Polymers / Q000008:administration & dosage*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000493:pharmacokinetics*
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D011108:Polymers; D014612:Vaccines
keywords: gene therapy; natural polymer; non-viral vectors; synthetic polymer; vaccine delivery