title: Twist and miR-34a are involved in the generation of tumor-educated myeloid-derived suppressor cells.
abstract: Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10.
authors.affiliation: Department of General Surgery, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China. sunmj@smmu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Xusheng
authors.initials: X
authors.lastname: Chang
authors.forename: Guangzuan
authors.initials: G
authors.lastname: Zhuo
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Sun
authors.forename: Kai
authors.initials: K
authors.lastname: Yin
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D051879:Twist-Related Protein 1 / Q000235:genetics* / Q000378:metabolism*
chemical_list: C556062:IL10 protein, mouse; C551848:MIRN34a microRNA, mouse; D035683:MicroRNAs; D016212:Transforming Growth Factor beta; D051879:Twist-Related Protein 1; D016753:Interleukin-10