title: Two rare cases of a solid pseudopapillary neoplasm of the pancreas.
abstract: A solid pseudopapillary neoplasm (SPN) of the pancreas has distinct histopathological features. A solid pattern of growth with pseudopapillary structures that result from degeneration is observed. On rare occasions, the tumor may vary from being entirely solid to completely cystic. The present study describes two unique cases of SPN. A 25-year-old male presented with a pancreatic tumor showing a predominantly solid pattern with no degenerative change, although the pre-operative cytological specimens that were obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) revealed pseudopapillary structures. The second case was of an 11-year-old female who presented with a pancreatic tumor with prominent degeneration. Nests and cords of the remaining neoplastic cells were located only at the periphery, with perineural invasion. An immunohistochemical analysis revealed that the tumor cells in the two cases were positive for CD10 and β-catenin and negative for trypsin. An awareness of the broad morphological variability of SPN and an immunohistochemical panel that includes CD10, β-catenin and trypsin are useful for establishing an accurate diagnosis.
authors.affiliation: Department of Pathology, Gifu University Hospital, Gifu 501-1194, Japan.
authors.forename: Chiemi
authors.initials: C
authors.lastname: Saigo
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Nami
authors.initials: N
authors.lastname: Asano
authors.forename: Manabu
authors.initials: M
authors.lastname: Takamatsu
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yasuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goshima
authors.forename: Michio
authors.initials: M
authors.lastname: Ozeki
authors.forename: Shinji
authors.initials: S
authors.lastname: Osada
keywords: CD10; cytology; solid-pseudopapillary neoplasm; trypsin; β-catenin