title: Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms.
abstract: Autophagy is involved in several physiological and pathological processes. One of the key roles of the autophagic pathway is to participate in the first line of defense against the invasion of pathogens, as part of the innate immune response. Targeting of intracellular bacteria by the autophagic machinery, either in the cytoplasm or within vacuolar compartments, helps to control bacterial proliferation in the host cell, controlling also the spreading of the infection. In this review we will describe the means used by diverse bacterial pathogens to survive intracellularly and how they are recognized by the autophagic molecular machinery, as well as the mechanisms used to avoid autophagic clearance.
authors.affiliation: Laboratorio de Biología Celular y Molecular, Facultad de Ciencias Médicas, Instituto de Histología y Embriología-CONICET, Universidad Nacional de Cuyo Mendoza, Argentina.
authors.forename: Maria Eugenia Mansilla
authors.initials: ME
authors.lastname: Pareja
authors.forename: Maria I
authors.initials: MI
authors.lastname: Colombo
mesh_terms: D001343:Autophagy; D001419:Bacteria / Q000276:immunology*; D003593:Cytoplasm / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D014617:Vacuoles / Q000382:microbiology*
keywords: autophagy; intracellular pathogens; phagocytosis; recognition; xenophagy