title: Facile regioselective synthesis of novel bis-thiazole derivatives and their antimicrobial activity.
abstract: The design and synthesis of several new bis-thiazoles 4a-h serving as bis-drugs in comparison with mono-heterocyclic analogs are described. These bis-drugs present superior medicinal and pharmacological activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with higher hydrophobicity. Compounds with higher hydrophobicity (4d and 4h) exhibited some activity against the gram-negative bacteria.
authors.affiliation: Faculty of Sciences, Department of Organic Chemistry, University of Guilan, Rasht, Iran.
authors.forename: Nosrat O
authors.initials: NO
authors.lastname: Mahmoodi
authors.forename: Jafar
authors.initials: J
authors.lastname: Parvizi
authors.forename: Bahman
authors.initials: B
authors.lastname: Sharifzadeh
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rassa
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013844:Thiazoles
keywords: Aminothiazole; Antibacterial; Regioselectivity; bis-Drugs