title: Maternal and neonatal outcomes in dichorionic twin pregnancies following IVF treatment: a hospital-based comparative study.
abstract: OBJECTIVE
  To compare maternal, and neonatal outcomes in IVF/ICSI and spontaneously conceived dichorionic twin pregnancy.
  
  
  METHODS
  We collected data regarding dichorionic twin pregnancies following in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI, n=162) with the transfer of fresh embryos as well as data regarding spontaneously conceived pregnancies (n=213) delivered after 28 weeks of gestation at the Department of Obstetrics and Gynecology, Renmin Hospital in Wuhan in the years of 2010-2013. We then compared maternal and neonatal outcomes between IVF/ICSI and spontaneous dichorionic twin pregnancies, with a subgroup analysis separating traditional IVF from ICSI pregnancies. Odds ratios (OR) for associations between IVF/ICSI and pregnancy outcomes were adjusted for maternal factors.
  
  
  RESULTS
  The mean maternal age and the percentage of primiparous women were significantly higher in the IVF/ICSI group. Multivariate analysis revealed that maternal outcomes were comparable in both groups with/without adjustment for maternal age and parity. However, IVF/ICSI twins were less likely to have birth weight discordance than those spontaneously conceived (unadjusted OR=0.526, 95% CI 0.297-0.932; adjusted OR=0.486, 95% CI 0.255-0.856). In subgroup analyses, these associations were confirmed in the IVF (adjusted OR=0.496, 95% CI 0.265-0.926), but not in the ICSI group (adjusted OR=0.500, 95% CI 0.139-1.807).
  
  
  CONCLUSIONS
  IVF/ICSI treatment was not a risk factor for adverse maternal neonatal outcomes, but the risk for birth weight discordance is lower among IVF/ICSI twins.
authors.affiliation: Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University Hubei, China ; Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University Hubei, China.
authors.forename: Cuifang
authors.initials: C
authors.lastname: Fan
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Jinping
authors.initials: J
authors.lastname: Ye
authors.forename: Suqing
authors.initials: S
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*
keywords: In vitro fertilization/intracytoplasmic sperm injection; dichorionic twin pregnancy; maternal outcome; neonatal outcome