title: The role of genetics in the pathogenesis of periocular cutaneous neoplasms: implications for targeted therapy.
abstract: In the past, cutaneous malignancies of the periocular region were primarily treated surgically with few other options. As the genetic bases of these tumors have become elucidated, targeted therapies aimed specifically at pathways that are felt to be responsible for cellular proliferation and uncontrolled growth have emerged with new promise. This review contains a summary of the various genetic implications of cutaneous neoplasms as well as their corresponding targeted systemic therapies.
authors.affiliation: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston , Massachusetts , USA.
authors.forename: Nahyoung Grace
authors.initials: NG
authors.lastname: Lee
authors.forename: Leo A
authors.initials: LA
authors.lastname: Kim
authors.forename: Suzanne K
authors.initials: SK
authors.lastname: Freitag
mesh_terms: D005142:Eyelid Neoplasms / Q000235:genetics* / Q000628:therapy; D006801:Humans; D008967:Molecular Biology; D058990:Molecular Targeted Therapy; D012878:Skin Neoplasms / Q000235:genetics* / Q000628:therapy