title: Immunosenescence and immune response in organ transplantation.
abstract: The immune system undergoes a complex and continuous remodeling with aging. Immunosenescence results into both quantitative and qualitative changes of specific cellular subpopulations that have major impact on allorecognition and alloresponse, and consequently on graft rejection and tolerance. Here, we are going to review the immunological changes associated with the aging process relevant for transplantation. Interventions to selectively target changes associated with the senescence process seem promising therapeutic strategies to improve transplantation outcome.
authors.affiliation: Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Paulo Ney Aguiar
authors.initials: PN
authors.lastname: Martins
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Tullius
authors.forename: James F
authors.initials: JF
authors.lastname: Markmann
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology*; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D016377:Organ Transplantation / Q000009:adverse effects / Q000379:methods*; D014181:Transplantation Immunology / Q000276:immunology
keywords: aging; elderly; immunosenescence; transplantation