title: Toward decentralized analysis of mercury (II) in real samples. A critical review on nanotechnology-based methodologies.
abstract: In recent years, it has increased the number of works focused on the development of novel nanoparticle-based sensors for mercury detection, mainly motivated by the need of low cost portable devices capable of giving fast and reliable analytical response, thus contributing to the analytical decentralization. Methodologies employing colorimetric, fluorometric, magnetic, and electrochemical output signals allowed reaching detection limits within the pM and nM ranges. Most of these developments proved their suitability in detecting and quantifying mercury (II) ions in synthetic solutions or spiked water samples. However, the state of art in these technologies is still behind the standard methods of mercury quantification, such as cold vapor atomic absorption spectrometry and inductively coupled plasma techniques, in terms of reliability and sensitivity. This is mainly because the response of nanoparticle-based sensors is highly affected by the sample matrix. The developed analytical nanosystems may fail in real samples because of the negative incidence of the ionic strength and the presence of exchangeable ligands. The aim of this review is to critically consider the recently published innovations in this area, and highlight the needs to include more realistic assays in future research in order to make these advances suitable for on-site analysis.
authors.affiliation: Laboratorio de Biomateriales, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Iguá 4225 casi Mataojo, 11400 Montevideo, Uruguay. Electronic address: sbotasini@fcien.edu.uy.
authors.forename: Santiago
authors.initials: S
authors.lastname: Botasini
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Heijo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Méndez
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry; D060766:Drinking Water / Q000032:analysis*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008628:Mercury / Q000032:analysis* / Q000097:blood; D008670:Metals / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*
chemical_list: D056831:Coordination Complexes; D060766:Drinking Water; D007477:Ions; D008670:Metals; D008628:Mercury
keywords: 1-(2-pyridylazo)-2-naphtol; 2,6-pyridinedicarboxylic acid; AgNDs; AgNPs; AgNTs; Amalgam; AuNDs; AuNPs; AuNRs; DFT; DNA; EDTA; Electrode; HCys; HF–LPME; LOD; MPA; Mercury (II) ion; Nanoparticle; PAN; PDCA; Real sample; SAMMS; SG; SPR; SYBR Green I; T–Hg(II)–T; density functional theory; deoxyribonucleic acid; double stranded deoxyribonucleic acid; dsDNA; ethylenediaminetetraacetic acid; gold nanodisks; gold nanoparticles; gold nanorods; hollow fiber-based liquid three-phase micro extraction; homocystine; limit of detection; mercaptopropionic acid; polyT–ssDNA; polythymine single stranded deoxyribonucleic acid; self-assembled monolayers on mesoporous silica; silver nanodisks; silver nanoparticles; silver nanotriangles; single stranded deoxyribonucleic acid; ssDNA; surface plasmon resonance; thymine–mercury (II)–thymine