title: Clinical staging: a necessary step in the development of improved animal models of mood disturbance?
abstract: Recently, it has been suggested that the clinical staging approach be considered a serious alternative framework for conceptualising mood related psychopathology. The fundamental difference between clinical staging and the now dominant categorical diagnostic framework is that the entire illness trajectory becomes relevant, as opposed to simply the end-stage. The concept of disease trajectory has significant implications for animal models of psychopathology, and particularly for animal models of depression. This article will introduce and discuss the implications of the clinical staging approach for those undertaking research using animal models of mood disturbance.
authors.affiliation: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
authors.forename: Frederick Rohan
authors.initials: FR
authors.lastname: Walker
authors.affiliation: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
authors.forename: Morgan H
authors.initials: MH
authors.lastname: James
authors.affiliation: Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
authors.affiliation: Department of Psychiatry, ORYGEN Youth Health Research Centre, University of Melbourne, VIC, Australia.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D019964:Mood Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy