title: Barrett's esophagus: cancer and molecular biology.
abstract: The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the merits of minimally invasive esophagectomy versus open surgery; outcomes for patients with pharyngolaryngoesophagectomy; the applications of neoadjuvant chemotherapy and chemoradiotherapy; animal models examining the surgical models of BE and esophageal adenocarcinoma; the roles of various morphogens and Cdx2 in BE; and the use of in vitro BE models for chemoprevention studies.
authors.affiliation: Department of Medicine and Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Gibson
authors.affiliation: Department of Medicine and Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Arashinder S
authors.initials: AS
authors.lastname: Dhaliwal
authors.affiliation: Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.|Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.|Department of Surgery, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Clemons
authors.affiliation: Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.|Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia.|Department of Surgery, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Wayne A
authors.initials: WA
authors.lastname: Phillips
authors.affiliation: Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona Cancer Center, Tucson, Arizona.
authors.forename: Katerina
authors.initials: K
authors.lastname: Dvorak
authors.affiliation: Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Hong Kong.
authors.forename: Daniel
authors.initials: D
authors.lastname: Tong
authors.affiliation: Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Hong Kong.
authors.forename: Simon
authors.initials: S
authors.lastname: Law
authors.affiliation: Servicio de Cirugía, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina.
authors.forename: E Daniel
authors.initials: ED
authors.lastname: Pirchi
authors.affiliation: Division of General Thoracic and Esophageal Surgery, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Jari
authors.initials: J
authors.lastname: Räsänen
authors.affiliation: Jersey Shore University Medical Center, Neptune, New Jersey.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Krasna
authors.affiliation: Department of Gastroenterology & Hepatology, and Centre for Experimental & Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Kaushal
authors.initials: K
authors.lastname: Parikh
authors.affiliation: Department of Gastroenterology & Hepatology, and Centre for Experimental & Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Kausilia K
authors.initials: KK
authors.lastname: Krishnadath
authors.affiliation: Department of Biology & Biochemistry, University of Bath, Bath, UK.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Biology & Biochemistry, University of Bath, Bath, UK.
authors.forename: Leonard
authors.initials: L
authors.lastname: Griffiths
authors.affiliation: Department of Biology & Biochemistry, University of Bath, Bath, UK.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Colleypriest
authors.affiliation: Department of Biology & Biochemistry, University of Bath, Bath, UK.
authors.forename: J Mark
authors.initials: JM
authors.lastname: Farrant
authors.affiliation: Department of Biology & Biochemistry, University of Bath, Bath, UK.
authors.forename: David
authors.initials: D
authors.lastname: Tosh
authors.affiliation: Department of Medicine, UMDNJ-RWJMS, New Brunswick, New Jersey.
authors.forename: Kiron M
authors.initials: KM
authors.lastname: Das
authors.affiliation: Department of Medicine, UMDNJ-RWJMS, New Brunswick, New Jersey.
authors.forename: Manisha
authors.initials: M
authors.lastname: Bajpai
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D001471:Barrett Esophagus / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D004947:Esophagus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics
chemical_list: D015850:Interleukin-6; D016328:NF-kappa B
keywords: Barrett's esophagus; MIE; esophageal adenocarcinoma; esophagectomy