title: Treatment of pediatric pyogenic granulomas using β-adrenergic receptor antagonists.
abstract: Propranolol and timolol are nonselective ß-adrenergic antagonists that induce peripheral vasoconstriction and affect angiogenic cytokines. Oral and topical ß-blocker therapy has become the de facto first-line treatment for complicated infantile hemangiomas because of its superior efficacy and tolerability. Pyogenic granulomas or lobular capillary hemangiomas are common acquired vascular tumors accounting for 0.5% of all skin nodules in children. Although they are benign vascular proliferations, treatment is often sought because of recurrent episodes of bleeding and for cosmetic considerations. Numerous treatment options are available, but recurrence rates are high. Noninvasive methods of treatment are being sought, particularly for young children. Herein we report a series of seven cases of cutaneous and mucosal pyogenic granulomas treated successfully using oral or topical ß-blockers.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Lara
authors.initials: L
authors.lastname: Wine Lee
authors.forename: Kiera L
authors.initials: KL
authors.lastname: Goff
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Lam
authors.forename: David W
authors.initials: DW
authors.lastname: Low
authors.forename: Albert C
authors.initials: AC
authors.lastname: Yan
authors.forename: Leslie
authors.initials: L
authors.lastname: Castelo-Soccio
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D017789:Granuloma, Pyogenic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D013999:Timolol; D011433:Propranolol