title: Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats.
abstract: BACKGROUND
  Although renal denervation (RD) is shown to reduce blood pressure significantly in patients with resistant hypertension, the benefit of RD in prevention of stroke is unknown. We hypothesized that RD can prevent the incidence of stroke and brain injury in hypertensive rats beyond blood pressure lowering.
  
  
  RESULTS
  High-salt-loaded, stroke-prone, spontaneously hypertensive rats (SHRSP) were divided into 4 groups: (1) control; (2) sham operation; (3) bilateral RD; and (4) hydralazine administration to examine the effect of RD on stroke and brain injury of SHRSP. RD significantly reduced the onset of neurological deficit and death in SHRSP, and this protection against stroke by RD was associated with the increase in cerebral blood flow (CBF), the suppression of blood-brain barrier disruption, the limitation of white matter (WM) lesions, and the attenuation of macrophage infiltration and activated microglia. Furthermore, RD significantly attenuated brain oxidative stress, and NADPH oxidase subunits, P67 and Rac1 in SHRSP. On the other hand, hydralazine, with similar blood pressure lowering to RD, did not significantly suppress the onset of stroke and brain injury in SHRSP. Furthermore, RD prevented cardiac remodeling and vascular endothelial impairment in SHRSP.
  
  
  CONCLUSIONS
  Our present work provided the first experimental evidence that RD can prevent hypertensive stroke and brain injury, beyond blood pressure lowering, thereby highlighting RD as a promising therapeutic strategy for stroke as well as hypertension.
authors.affiliation: Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1-1-1 HonjyoChuo-ku, Kumamoto, 860-8556, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Yu
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Ken
authors.initials: K
authors.lastname: Uekawa
authors.forename: Mingjie
authors.initials: M
authors.lastname: Ma
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Katayama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sueta
authors.forename: Kensuke
authors.initials: K
authors.lastname: Toyama
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kataoka
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Koibuchi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Maeda
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kuratsu
authors.forename: Shokei
authors.initials: S
authors.lastname: Kim-Mitsuyama
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001927:Brain Diseases / Q000209:etiology* / Q000517:prevention & control*; D003714:Denervation; D006973:Hypertension / Q000150:complications* / Q000378:metabolism*; D007668:Kidney / Q000294:innervation* / Q000601:surgery*; D008297:Male; D018384:Oxidative Stress; D011918:Rats, Inbred SHR; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control*
keywords: hypertension; oxidative stress; renal denervation; stroke; sympathetic nerve