title: Local cAMP signaling in disease at a glance.
abstract: The second messenger cyclic AMP (cAMP) operates in discrete subcellular regions within which proteins that synthesize, break down or respond to the second messenger are precisely organized. A burgeoning knowledge of compartmentalized cAMP signaling is revealing how the local control of signaling enzyme activity impacts upon disease. The aim of this Cell Science at a Glance article and the accompanying poster is to highlight how misregulation of local cyclic AMP signaling can have pathophysiological consequences. We first introduce the core molecular machinery for cAMP signaling, which includes the cAMP-dependent protein kinase (PKA), and then consider the role of A-kinase anchoring proteins (AKAPs) in coordinating different cAMP-responsive proteins. The latter sections illustrate the emerging role of local cAMP signaling in four disease areas: cataracts, cancer, diabetes and cardiovascular diseases.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Gold
authors.forename: Tamir
authors.initials: T
authors.lastname: Gonen
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D002386:Cataract / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D015290:Second Messenger Systems
chemical_list: D000242:Cyclic AMP