title: The promise of riboswitches as potential antibacterial drug targets.
abstract: Riboswitches represent promising novel RNA structures for developing compounds that artificially regulate gene expression and, thus, bacterial growth. The past years have seen increasing efforts to identify metabolite-analogues which act on riboswitches and which reveal antibacterial activity. Here, we summarize the current inventory of riboswitch-targeting compounds, their characteristics and antibacterial potential.
authors.affiliation: Life & Medical Sciences Institute, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Lünse
authors.affiliation: Life & Medical Sciences Institute, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Schüller
authors.affiliation: Life & Medical Sciences Institute, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany. Electronic address: gmayer@uni-bonn.de.
authors.forename: Günter
authors.initials: G
authors.lastname: Mayer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D058928:Riboswitch / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D058928:Riboswitch
keywords: Adenine; FMN; Glucosamin-6-phosphate; Guanine; Lysine; Metabolite; Riboswitch; Ribozyme; TPP