title: Comparison of Bayesian methods for flexible modeling of spatial risk surfaces in disease mapping.
abstract: Bayesian hierarchical models usually model the risk surface on the same arbitrary geographical units for all data sources. Poisson/gamma random field models overcome this restriction as the underlying risk surface can be specified independently to the resolution of the data. Moreover, covariates may be considered as either excess or relative risk factors. We compare the performance of the Poisson/gamma random field model to the Markov random field (MRF)-based ecologic regression model and the Bayesian Detection of Clusters and Discontinuities (BDCD) model, in both a simulation study and a real data example. We find the BDCD model to have advantages in situations dominated by abruptly changing risk while the Poisson/gamma random field model convinces by its flexibility in the estimation of random field structures and by its flexibility incorporating covariates. The MRF-based ecologic regression model is inferior. WinBUGS code for Poisson/gamma random field models is provided.
authors.affiliation: Department of Medical Biometry, Institute for Quality and Efficiency in Health Care, Im Mediapark 8, 50670, Köln, Germany; Faculty of Statistics, TU Dortmund University, 44221, Dortmund, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Sturtz
authors.forename: Katja
authors.initials: K
authors.lastname: Ickstadt
mesh_terms: D001499:Bayes Theorem; D001699:Biometry / Q000379:methods*; D016000:Cluster Analysis; D006801:Humans; D007938:Leukemia / Q000453:epidemiology; D015233:Models, Statistical; D016012:Poisson Distribution; D012044:Regression Analysis; D012306:Risk
keywords: Disease mapping; Poisson/gamma random field model; Spatial statistics