title: Effect of propofol on anal sphincter pressure during anorectal manometry.
abstract: We evaluated the effect of propofol on resting anal sphincter pressure (RP) during anorectal manometry performed under general anesthesia in 20 children with chronic constipation. After propofol bolus administration, there was a significant decrease in the RP in 95% of children from a mean of 51.5 ± 15.3 to a mean nadir of 21.7 ± 10.5 mmHg (P < 0.001). The new postpropofol RP of 47.0 ± 12.4 mmHg was significantly lower compared with prepropofol RP (P < 0.0001). Propofol should be used with caution as an anesthetic agent for anorectal manometry, given the potential for confounding RP measurements.
authors.affiliation: *Department of Pediatric Gastroenterology, New England Medical Center †Gastroenterology Unit, Massachusetts General Hospital ‡Department of Anesthesia §Division of Gastroenterology, Hepatology, and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston.
authors.forename: Khoa
authors.initials: K
authors.lastname: Tran
authors.forename: Brad
authors.initials: B
authors.lastname: Kuo
authors.forename: Audrius
authors.initials: A
authors.lastname: Zibaitis
authors.forename: Somaletha
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Charles
authors.initials: C
authors.lastname: Cote
authors.forename: Jaime
authors.initials: J
authors.lastname: Belkind-Gerson
mesh_terms: D001003:Anal Canal / Q000187:drug effects* / Q000503:physiopathology; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D011312:Pressure; D015742:Propofol / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol