title: [Peculiarities of ocular blood flow in ischemic optic neuropathy and normal tension glaucoma].
abstract: Characteristics of ocular hemodynamics in ischemic optic neuropathy (ION) outcome and normal tension glaucoma (NTG), the conditions that are difficult to be differentially diagnosed, have been investigated. The study enrolled 32 patients (40 eyes) with ION outcome, 26 patients (46 eyes) with NTG, and 20 patients (32 eyes) with no ocular pathology. Besides the standard ophthalmological examination, color Doppler imaging of ocular vessels, evaluation of ocular blood flow volume and individual normal range of intraocular pressure (flowmetry) were performed in all cases. The results showed that an excess of the actual intraocular pressure (IOP) over the individual normal range was much higher in patients with NTG than in patients with ION (39% and 14.5% correspondingly). It was also found that NTG is associated with a more significant decrease of ocular blood flow volume (30.1% in average) in comparison to ION outcome (11%). In both conditions a decrease in velocity parameters of the blood flow in main ocular vessels was registered, however, ocular hemodynamics changes appeared to be more severe in patients with glaucomatous optic neuropathy. A statistically reliable correlation between volumetric and velocity parameters of ocular blood flow has been discovered.
authors.forename: V R
authors.initials: VR
authors.lastname: Mamikonian
authors.forename: N S
authors.initials: NS
authors.lastname: Galoian
authors.forename: N L
authors.initials: NL
authors.lastname: Sheremet
authors.forename: E E
authors.initials: EE
authors.lastname: Kazarian
authors.forename: S I
authors.initials: SI
authors.lastname: Kharlap
authors.forename: O A
authors.initials: OA
authors.lastname: Shmeleva-Demir
authors.forename: D V
authors.initials: DV
authors.lastname: Andzhelova
authors.forename: A A
authors.initials: AA
authors.lastname: Tatevosian
mesh_terms: D005123:Eye / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018917:Optic Neuropathy, Ischemic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology*; D012720:Severity of Illness Index; D014065:Tonometry, Ocular; D018615:Ultrasonography, Doppler, Color