title: [Impact of endocrine disrupting chemicals on birth outcomes].
abstract: BACKGROUND
  Endocrine disruptors are ubiquitous chemicals contaminants in the environment, wildlife, and humans. Their adverse effects on reproduction are well-documented. There is growing evidence that they can contribute to the current emergence of chronic diseases.
  
  
  OBJECTIVE
  Our aim is to assess the relationships between endocrine disruptors and the neonatal health outcomes.
  
  
  METHODS
  Two persons have independently reviewed Medline and Toxline databases about the following pollutants: bisphenol A, phthalates, parabens, brominated flame retardants and perfluorinated compounds. Only the human epidemiological studies, in general population with an abstract available, published between 2007 January the 1st and 2011 December the 31st, were analysed. The quality of each study was assessed with the Strobe score.
  
  
  RESULTS
  Twenty-five out of 680 studies were included in the analysis. All pollutants were widely detected in maternal and new borns samples. Most of the studies have shown associations between bisphenol A, brominated flame retardants and perfluorinated compounds and lower birth weight. The effects on gestational age were less documented and have shown no clear connection. Results for phthalates were more ambiguous. Only one non-instructive study was found on parabens.
  
  
  CONCLUSIONS
  Due to the inherent methological bias on endocrine disruptors research, further additional studies on environmental health must be investigated. It seems necessary to adopt preventive health measures first for vulnerable population.
authors.affiliation: Département de médecine générale, faculté de médecine Pierre et Marie Curie, 27, rue de Chaligny, 75012 Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Chen Zee
authors.forename: P
authors.initials: P
authors.lastname: Cornet
authors.forename: G
authors.initials: G
authors.lastname: Lazimi
authors.forename: C
authors.initials: C
authors.lastname: Rondet
authors.forename: M
authors.initials: M
authors.lastname: Lochard
authors.forename: A M
authors.initials: AM
authors.lastname: Magnier
authors.forename: G
authors.initials: G
authors.lastname: Ibanez
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005411:Flame Retardants / Q000032:analysis; D005466:Fluorocarbons / Q000032:analysis; D005865:Gestational Age; D006304:Health Status; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D010636:Phenols / Q000032:analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D005411:Flame Retardants; D005466:Fluorocarbons; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Birth outcomes; Bisphenol A; Bisphénol A; Brominated flame retardants; Composés perfluorés; Endocrine disruptors; Exposition prénatale; Marqueurs de la périnatalité; Parabens; Perfluorinated compounds; Perturbateurs endocriniens; Phtalates; Phthalates; Prenatal exposure; Retardateurs de flammes bromés