title: Anticancer activity of ferrocenylthiosemicarbazones.
abstract: Aliphatic and aromatic ferrocenylthiosemicarbazones were synthesized. The characterization of the new ferrocenylthiosemicarbazones was done by IR, (1)H-NMR and (13)C-NMR spectroscopy, elemental analysis and X-ray diffraction studies. The biological activity of the obtained compounds was assessed in terms of anticancer activity. Their activity against U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma), K562 (human chronic myelogenous leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma) and SKLU-1 (human lung adenocarcinoma) cell lines was studied and compared with cisplatin. All tested compounds showed good activity and the aryl-chloro substituted ferrocenylthiosemicarbazones showed the best anticancer activity.
authors.forename: Cortez-Maya
authors.initials: CM
authors.lastname: Sandra
authors.forename: Klimova
authors.initials: K
authors.lastname: Elena
authors.forename: Flores-Alamo
authors.initials: FA
authors.lastname: Marcos
authors.forename: Martínez-Klimova
authors.initials: MK
authors.lastname: Elena
authors.forename: Ramírez-Ramírez
authors.initials: RR
authors.lastname: Arturo
authors.forename: Ramírez Apan
authors.initials: RA
authors.lastname: Teresa
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, C.P. 04510, México D.F., México. sandra.crtz@gmail.com.
authors.forename: Martínez-García
authors.initials: MG
authors.lastname: Marcos
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000075163:Metallocenes; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005296:Ferrous Compounds; D000075163:Metallocenes; D013882:Thiosemicarbazones; D002945:Cisplatin; C004998:ferrocene