title: SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican type 2 diabetes patients: a comparative study and meta-analysis.
abstract: BACKGROUND
  Several studies in type 2 diabetes patients have shown significant associations between the SOD2 gene Val16Ala polymorphism and albuminuria, but this association has not been explored in the Mexican population.
  
  
  METHODS
  We evaluated the association between the SOD2 gene Val16Ala polymorphism (rs4880) and macroalbuminuria in a sample of 994 unrelated Mexican type 2 diabetes patients. The study included 119 subjects with urinary albumin >300 mg/dL and 875 subjects with urinary albumin ≤ 30 mg/dL. Genotyping of the SOD2 gene Val16Ala SNP was carried out with Real-Time Polymerase Chain Reaction (RT-PCR).
  
  
  RESULTS
  The frequency of the TT genotype was 6.7% higher in participants with macroalbuminuria than in the normoalbuminuria group (16.8% vs. 10.1%). Using a logistic regression analysis, we observed that individuals with the CC genotype had significantly lower risks of macroalbuminuria than those with the TT genotype (OR=0.42, p=0.034). We carried out a meta-analysis combining our data with data from four previous studies and estimated an odds ratio (95% CI) for the C allele (with respect to the reference T allele) of 0.65 (0.52-0.80, p<0.001).
  
  
  CONCLUSIONS
  A significant association was found between the SOD2 Val16Ala polymorphism and macroalbuminuria in a sample of Mexican type 2 diabetes patients.
authors.affiliation: Biochemistry Research Unit, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico DF, Mexico. mcruzl@yahoo.com.
authors.forename: Iván de Jesús
authors.initials: Ide J
authors.lastname: Ascencio-Montiel
authors.forename: Esteban J
authors.initials: EJ
authors.lastname: Parra
authors.forename: Adán
authors.initials: A
authors.lastname: Valladares-Salgado
authors.forename: Jaime H
authors.initials: JH
authors.lastname: Gómez-Zamudio
authors.forename: Jesús
authors.initials: J
authors.lastname: Kumate-Rodriguez
authors.forename: Jorge
authors.initials: J
authors.lastname: Escobedo-de-la-Peña
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications / Q000235:genetics*; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D000099156:Superoxide Dismutase 2
chemical_list: D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2