title: 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications.
abstract: Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships.
authors.affiliation: Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Bangkok, Thailand.
authors.forename: Veda
authors.initials: V
authors.lastname: Prachayasittikul
authors.forename: Supaluk
authors.initials: S
authors.lastname: Prachayasittikul
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.forename: Virapong
authors.initials: V
authors.lastname: Prachayasittikul
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D008670:Metals / Q000378:metabolism*; D015125:Oxyquinoline / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002614:Chelating Agents; D006912:Hydroxyquinolines; D008670:Metals; D015125:Oxyquinoline
keywords: anticancer; antidiabetic; antineurodegenerative; metal binding compound; multifunctional actions; structure-activity relationships