title: A case of myocarditis following neonatal meningitis caused by coxsackievirus B1 in spite of intravenous immunoglobulin treatment.
abstract: Enteroviral infection is one of the most common neonatal infections, and most patients recover without complications. This report describes a neonate who experienced meningitis followed by myocarditis. A 4-day-old boy was admitted with fever, diagnosed with enteroviral meningitis and treated with intravenous immunoglobulin (IVIG). However, myocarditis was subsequently diagnosed in spite of IVIG treatment, and coxsackievirus B1 (CXB1) was revealed as a cause. A left ventricular aneurysm persisted even though the patient recovered with repeated high-dose IVIG treatment and cardiac supportive care. This report describes a rare case where myocarditis developed several days after a diagnosis of CXB1 meningitis in spite of IVIG treatment. It is important to pay attention to the patient's clinical condition until the end of the second viremia of enterovirus and to consider high-dose IVIG treatment when treating enteroviral infections for neonates.
authors.affiliation: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: E Young
authors.initials: EY
authors.lastname: Bae
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Seung Beom
authors.initials: SB
authors.lastname: Han
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Jeong
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D061605:Administration, Intravenous; D003384:Coxsackievirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D029822:Enterovirus B, Human / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D008582:Meningitis, Aseptic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D009205:Myocarditis / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: coxsackievirus infections; intravenous immunoglobulins; meningitis; myocarditis; newborn