title: Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes.
abstract: Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3 -functionalized acrylamide derivatives.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China).
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004583:Electrons; D005461:Fluorine / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008745:Methylation; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D005461:Fluorine; D002244:Carbon; D003300:Copper; D006859:Hydrogen
keywords: CH activation; alkenes; copper; cross-coupling; trifluoromethylation