title: Public health genomics and personalized prevention: lessons from the COGS project.
abstract: Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at the population level. Our model-based estimates indicate that polygenic risk stratification can potentially improve the effectiveness and cost-effectiveness of screening programmes. However, compared with 'one-size-fits-all' screening programmes, personalized screening adds further layers of complexity to the organization of screening services and raises ethical, legal and social challenges. Before polygenic inheritance is translated into population screening strategy, evidence from empirical research and engagement with and education of the public and the health professionals are needed.
authors.affiliation: Department of Applied Health Research, University College London, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Pashayan
authors.forename: A
authors.initials: A
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Chowdhury
authors.forename: T
authors.initials: T
authors.lastname: Dent
authors.forename: P D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: H
authors.initials: H
authors.lastname: Burton
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D023281:Genomics / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D057285:Precision Medicine / Q000379:methods*; D018570:Risk Assessment
keywords: ethical; legal and social issues; personalized prevention; polygenic risk stratification; public health genomics; screening