title: Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study.
abstract: BACKGROUND
  Experimental and clinical trials have indicated that dietary supplements can have beneficial effects on skin health.
  
  
  OBJECTIVE
  We investigated to evaluate the effect of daily collagen peptide (CP) supplement on skin properties.
  
  
  METHODS
  Thirty-two healthy volunteers were randomized to receive either no supplement (Group A), CP 3 g (Group B), CP 3 g, and vitamin C 500 mg (Group C), or vitamin C 500 mg (Group D) daily for 12 weeks. Skin properties evaluated included hydration, transepidermal water loss (TEWL), and elasticity using a corneometer, tewameter, and cutometer, respectively.
  
  
  RESULTS
  Changes from baseline in the corneometer were statistically significant between Groups A and B (p = 0.011) and Groups A and C (p = 0.004). There were statistically significant differences in cutometer from baseline between Groups A and B (p = 0.005) and Groups A and C (p = 0.015). There was no significant difference from baseline in the corneometer and cutometer between Groups B and C. The greatest changes in TEWL from baseline were seen in Group B, and the second greatest changes were seen in Group C.
  
  
  CONCLUSIONS
  Daily CP supplementation may improve skin hydration and elasticity, but concomitant intake of low-dose vitamin C did not enhance the effect of CP on skin properties.
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine , Seoul , South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Ko
authors.forename: Yong Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Byung Gyu
authors.initials: BG
authors.lastname: Kim
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Shin
authors.forename: Dae Bang
authors.initials: DB
authors.lastname: Seo
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Myeung Nam
authors.initials: MN
authors.lastname: Kim
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D056910:Republic of Korea; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects*; D014867:Water
chemical_list: D014867:Water; D003094:Collagen; D001205:Ascorbic Acid
keywords: collagen tripeptide; skin elasticity; skin hydration