title: Rethinking antioxidants in the intensive care unit.
abstract: Recently there was yet another clinical trial using antioxidants that failed in patients with critical illness. In this perspective, we suggest that antioxidants likely interfere with the normal immune response, thus contributing to the lack of efficacy in patients with critical illness.
authors.affiliation: 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Manu
authors.initials: M
authors.lastname: Jain
authors.forename: Navdeep S
authors.initials: NS
authors.lastname: Chandel
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000502:physiology / Q000627:therapeutic use*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology; D007362:Intensive Care Units; D018384:Oxidative Stress / Q000187:drug effects / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species