title: Mechanism of suppression of phagocytic and metabolic activity of neutrophils and production of proinflammatory cytokines during chronic poisoning with organophosphorus compounds.
abstract: Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds (Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils. The reduction of functional activity of monocyte phagocytic system was stipulated by the stimulation of N-cholinergic receptors of these cells. These changes were accompanied by a decrease in blood concentration of proinflammatory cytokines (TNF-α, IL-1β, and IL-6).
authors.affiliation: V. I. Razumovskii Saratov State Medical University, Saratov, Russia. pfzabrodsky@gmail.com.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V A
authors.initials: VA
authors.lastname: Grishin
authors.forename: V K
authors.initials: VK
authors.lastname: Borodavko
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D018836:Inflammation Mediators; D007928:Lethal Dose 50; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000633:toxicity; D018722:Nicotinic Agonists / Q000633:toxicity; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D012524:Sarin / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D016207:Cytokines; D018836:Inflammation Mediators; D018722:Nicotinic Agonists; D009946:Organothiophosphorus Compounds; D009538:Nicotine; D012524:Sarin; C451779:S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate