title: Disseminated adenovirus infection in cancer patients presenting with focal pulmonary consolidation.
abstract: We report disseminated adenovirus (ADV) infection in four adult cancer patients presenting with focal pulmonary consolidation. In all cases, ADV was recovered from respiratory specimens and ADV viremia (>1 × 10(5) copies/ml) was determined by a quantitative PCR assay. Despite antiviral therapy, 3 (75%) patients died. ADV should be considered as a possible cause of severe pneumonia in immunosuppressed patients.
authors.affiliation: Infectious Disease, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Yeon Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Paola
authors.initials: P
authors.lastname: Palomino-Guilen
authors.forename: N Esther
authors.initials: NE
authors.lastname: Babady
authors.forename: Daryl M
authors.initials: DM
authors.lastname: Lamson
authors.forename: Kirsten
authors.initials: K
authors.lastname: St George
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Tang
authors.forename: Genovefa A
authors.initials: GA
authors.lastname: Papanicolaou
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009369:Neoplasms / Q000150:complications*; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D014766:Viremia / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral