title: Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients.
abstract: OBJECTIVE
  Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population.
  
  
  METHODS
  We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days.
  
  
  RESULTS
  In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure.
  
  
  CONCLUSIONS
  Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kwandong University Medical College, 24 Beomil-ro 579beon-gil, Gangneung 210-701, Korea. diva502@kd.ac.kr.
authors.forename: Seun Deuk
authors.initials: SD
authors.lastname: Hwang
authors.forename: Yoon Ji
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sang Heun
authors.initials: SH
authors.lastname: Lee
authors.forename: Deok Kyu
authors.initials: DK
authors.lastname: Cho
authors.forename: Yun Hyeong
authors.initials: YH
authors.lastname: Cho
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Moon
authors.forename: Sang Choel
authors.initials: SC
authors.lastname: Lee
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Yoon
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D003287:Contrast Media
keywords: Oxidative stress; contrast media; hemodialysis