title: Epigenetic choreography of stem cells: the DNA demethylation episode of development.
abstract: Reversible DNA methylation is a fundamental epigenetic manipulator of the genomic information in eukaryotes. DNA demethylation plays a very significant role during embryonic development and stands out for its contribution in molecular reconfiguration during cellular differentiation for determining stem cell fate. DNA demethylation arbitrated extensive make-over of the genome via reprogramming in the early embryo results in stem cell plasticity followed by commitment to the principal cell lineages. This article attempts to highlight the sequential phases and hierarchical mode of DNA demethylation events during enactment of the molecular strategy for developmental transition. A comprehensive knowledge regarding the pattern of DNA demethylation during embryogenesis and organogenesis and study of the related lacunae will offer exciting avenues for future biomedical research and stem cell-based regenerative therapy.
authors.affiliation: Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India.
authors.forename: Swayamsiddha
authors.initials: S
authors.lastname: Kar
authors.forename: Sabnam
authors.initials: S
authors.lastname: Parbin
authors.forename: Moonmoon
authors.initials: M
authors.lastname: Deb
authors.forename: Arunima
authors.initials: A
authors.lastname: Shilpi
authors.forename: Dipta
authors.initials: D
authors.lastname: Sengupta
authors.forename: Sandip Kumar
authors.initials: SK
authors.lastname: Rath
authors.forename: Madhumita
authors.initials: M
authors.lastname: Rakshit
authors.forename: Aditi
authors.initials: A
authors.lastname: Patra
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Patra
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation / Q000235:genetics*; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D016678:Genome; D006801:Humans; D039904:Pluripotent Stem Cells / Q000378:metabolism
chemical_list: D004247:DNA