title: Secondary prophylaxis of docetaxel induced diarrhea with loperamide: case report.
abstract: Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%. Several treatment guidelines for chemotherapy induced diarrhea (CID) exist, however the prophylaxis for that is not well known. We describe a new prophylactic approach for the CID with loperamide. A 72-yr-old male patient with stage IV non-small-cell lung cancer developed diarrhea repeatedly after docetaxel-cisplatin chemotherapy. His diarrhea persisted despite treatment including loperamide and fasting. However, the diarrhea was successfully prevented when loperamide was given before and after the chemotherapy. To our knowledge, this is the first report of prophylactic approach for the CID with loperamide.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Lee
authors.forename: Youn Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hoon-Kyo
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000209:etiology*; D000077143:Docetaxel; D004359:Drug Therapy, Combination; D006801:Humans; D008139:Loperamide / Q000009:adverse effects* / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D009367:Neoplasm Staging; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D008139:Loperamide; D002945:Cisplatin
keywords: Diarrhea; Docetaxel; Loperamide