title: Self-reported sleep and β-amyloid deposition in community-dwelling older adults.
abstract: OBJECTIVE
  Older adults commonly report disturbed sleep, and recent studies in humans and animals suggest links between sleep and Alzheimer disease biomarkers. Studies are needed that evaluate whether sleep variables are associated with neuroimaging evidence of β-amyloid (Aβ) deposition. OBJECTIVE To determine the association between self-reported sleep variables and Aβ deposition in community-dwelling older adults.
  
  
  METHODS
  Cross-sectional study of 70 adults (mean age, 76 [range, 53-91] years) from the neuroimaging substudy of the Baltimore Longitudinal Study of Aging, a normative aging study. EXPOSURE Self-reported sleep variables. MAIN OUTCOMES AND MEASURES β-Amyloid burden, measured by carbon 11-labeled Pittsburgh compound B positron emission tomography distribution volume ratios (DVRs).
  
  
  RESULTS
  After adjustment for potential confounders, reports of shorter sleep duration were associated with greater Aβ burden, measured by mean cortical DVR (B = 0.08 [95% CI, 0.03-0.14]; P = .005) and precuneus DVR (B = 0.11 [0.03-0.18]; P = .007). Reports of lower sleep quality were associated with greater Aβ burden measured by precuneus DVR (B = 0.08 [0.01-0.15]; P = .03).
  
  
  CONCLUSIONS
  Among community-dwelling older adults, reports of shorter sleep duration and poorer sleep quality are associated with greater Aβ burden. Additional studies with objective sleep measures are needed to determine whether sleep disturbance causes or accelerates Alzheimer disease.
authors.affiliation: Department of Mental Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Spira
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Alyssa A
authors.initials: AA
authors.lastname: Gamaldo
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Yang
authors.initials: Y
authors.lastname: An
authors.affiliation: Departments of Neurology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Wu
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Simonsick
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland4Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Murat
authors.initials: M
authors.lastname: Bilgel
authors.affiliation: Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland6Departments of Psychiatry and Behavioral Sciences and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Dean F
authors.initials: DF
authors.lastname: Wong
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Resnick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism* / Q000502:physiology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D012111:Residence Characteristics; D057566:Self Report; D012893:Sleep Wake Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D013844:Thiazoles