title: Lower metabolic clearance of tizanidine in Japanese subjects.
abstract: Our aim was to determine whether metabolic clearance, renal clearance, or both elimination pathways contribute to ethnic differences in tizanidine clearance, which is ~ 2-fold higher in Caucasians than in Asians. The pharmacokinetic parameters of tizanidine in 9 healthy male Japanese subjects were compared with those of Caucasians in previous studies. Metabolic clearance of tizanidine was lower in Japanese than in Caucasian subjects (5.9 vs. 8.1 - 10.9 l/h/kg), although renal clearances were similar (0.040 vs. 0.047 - 0.055 l/h/kg). The results suggest that ethnic differences in tizanidine clearance are due to differences in metabolic clearance.
authors.forename: Kenji
authors.initials: K
authors.lastname: Momo
authors.forename: Masato
authors.initials: M
authors.lastname: Homma
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Kohda
mesh_terms: D000328:Adult; D044466:Asian People; D003000:Clonidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D019388:Cytochrome P-450 CYP1A2 / Q000502:physiology; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D044465:White People
chemical_list: C023754:tizanidine; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; D003000:Clonidine