title: NKp30 enables NK cells to act naturally with fungi.
abstract: NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.
authors.affiliation: Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.
authors.forename: Jessica
authors.initials: J
authors.lastname: Quintin
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Levitz
mesh_terms: D002175:Candida / Q000276:immunology*; D003454:Cryptococcus / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000096:biosynthesis*
chemical_list: C431710:NCR3 protein, human; D055628:Natural Cytotoxicity Triggering Receptor 3