title: Functional activity and effective connectivity of the posterior medial prefrontal cortex during processing of incongruent mental states.
abstract: The neurocognitive components of Theory of Mind reasoning remain poorly understood. In particular the role of the posterior medial prefrontal cortex in the processing of other's mental states such as beliefs that are incongruent with one's own knowledge of reality is not clear-cut. It is unknown whether this region is involved in computing discrepant mental states or in subsequently resolving a response conflict between the discrepant others' and one's own beliefs. To test this, we adapted a false belief paradigm for the separate inspection of functional brain activity related to (1) the computation of diverging beliefs and (2) the subsequent consideration and selection of another's or one's own belief. Based on statistical parametric findings from functional neuroimaging, we employed dynamic causal modelling combined with Bayesian model selection to further characterize the interplay of resulting brain regions. In the initial computation of diverging beliefs, the posterior medial prefrontal cortex (pMPFC) and the bilateral temporoparietal cortex were crucially involved. The findings suggest that the bilateral temporal cortex engages in the construction and adjustment of diverging mental states by encoding relevant environmental information. The pMPFC inhibits this stimulus-bound processing which helps to compute discrepant mental states and process another's false belief decoupled from one's own perception of reality. In the subsequent question phase the right temporoparietal cortex showed increased activity related to switching to and reconsidering another's beliefs in order to select the correct response.
authors.affiliation: Department of Psychology, Ludwig-Maximilians-University, Munich, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schuwerk
authors.forename: Katrin
authors.initials: K
authors.lastname: Döhnel
authors.forename: Beate
authors.initials: B
authors.lastname: Sodian
authors.forename: Ingo R
authors.initials: IR
authors.lastname: Keck
authors.forename: Rainer
authors.initials: R
authors.lastname: Rupprecht
authors.forename: Monika
authors.initials: M
authors.lastname: Sommer
mesh_terms: D000328:Adult; D001499:Bayes Theorem; D001931:Brain Mapping; D003220:Conflict, Psychological; D003469:Culture; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D056345:Theory of Mind / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: decoupling; dynamic causal modelling; effective connectivity; false belief task; posterior medial prefrontal cortex; temporoparietal cortex; theory of mind reasoning