title: Post-translational control of cardiac hemodynamics through myosin binding protein C.
abstract: Cardiac myosin binding protein C (cMyBP-C) is an integral sarcomeric protein that associates with the thick, thin, and titin filament systems in the contractile apparatus. Three different isoforms of MyBP-C exist in mammalian muscle: slow skeletal (MyBPC1), fast skeletal (MyBP-C2, with several variants), and cardiac (cMyBP-C). Genetic screening studies show that mutations in MYBPC3 occur frequently and are responsible for as many as 30-35 % of identified cases of familial hypertrophic cardiomyopathy. The function of cMyBP-C is stringently regulated by its post-translational modification. In particular, the addition of phosphate groups occurs with high frequency on certain serine residues that are located in the cardiac-specific regulatory M domain. Phosphorylation of this domain has been extensively studied in vitro and in vivo. Phosphorylation of the M domain can regulate the manner in which actin and myosin interact, affecting the cross bridge cycle and ultimately, cardiac hemodynamics.
authors.affiliation: The Heart Institute, Department of Pediatrics, The Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Gupta
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Robbins
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D009210:Myofibrils / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D012518:Sarcomeres / Q000378:metabolism; D000099163:Myosin Binding Protein C
chemical_list: D000199:Actins; D002352:Carrier Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D009218:Myosins; D000099163:Myosin Binding Protein C