title: Neuroendocrine carcinoma of the skin--an updated review.
abstract: Primary neuroendocrine carcinoma of the skin, or Merkel Cell carcinoma (MCC), is a rare but aggressive tumor. Many recent advances on the morphology, immunophenotype, and pathogenesis have come to light in recent years. This review highlights the clinical features, varying histologies, histogenesis, advances in molecular pathology, prognosis, and current management of MCC. It also aims to aid in the differential diagnosis, with an emphasis on neuroendocrine tumors, and approach to the diagnosis of MCC with the use of immunohistochemistry and molecular studies.
authors.affiliation: Department of Pathology, University Health Network, Toronto General Hospital, Floor 11-E 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.
authors.forename: Marie Abi
authors.initials: MA
authors.lastname: Daoud
authors.forename: Ozgur
authors.initials: O
authors.lastname: Mete
authors.forename: Ayman
authors.initials: A
authors.lastname: Al Habeeb
authors.forename: Danny
authors.initials: D
authors.lastname: Ghazarian
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology*