title: Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines.
abstract: Autoimmune hepatitis (AIH) has been reported in association with Sjögren's syndrome (SS). Drug-induced AIH has been rarely reported. A rare case of the co-development of AIH and SS in a 53-year-old woman after the consumption of herbal medicines is described. After admission, the patient complained of dryness in her mouth, and she was subsequently diagnosed with SS, which had not been detected previously. The patient's bilirubin and aminotransferase levels initially decreased following conservative management; however, they later began to progressively increase. A diagnosis of AIH was made based on the scoring system proposed by the International Autoimmune Hepatitis Group. The patient was administered a combination of prednisolone and azathioprine, and the results of follow-up liver-function tests were found to be within the normal range. This is an unusual case of AIH and SS triggered simultaneously by the administration of herbal medicines.
authors.affiliation: Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea.
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Oh
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Mok
authors.forename: Moon Seong
authors.initials: MS
authors.lastname: Baek
authors.forename: Ji Kyeong
authors.initials: JK
authors.lastname: Lee
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Seo
authors.forename: Tae Hyeon
authors.initials: TH
authors.lastname: Kim
authors.forename: Keum Ha
authors.initials: KH
authors.lastname: Choi
authors.forename: In Kyeom
authors.initials: IK
authors.lastname: Hwang
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Ra
authors.forename: Yong-Reol
authors.initials: YR
authors.lastname: Oh
authors.forename: Yong Sung
authors.initials: YS
authors.lastname: Kim
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Cho
authors.forename: Haak Cheoul
authors.initials: HC
authors.lastname: Kim
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Sohn
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001379:Azathioprine / Q000627:therapeutic use; D001663:Bilirubin / Q000097:blood; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D029001:Herbal Medicine; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D011239:Prednisolone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001379:Azathioprine; D001663:Bilirubin
keywords: Autoimmune hepatitis; Herbal medicine; Sjögren's syndrome