title: [Association of estrogen receptor β gene polymorphisms with hypertension in postmenopausal women].
abstract: OBJECTIVE
  To explore the association between estrogen receptor β (ERβ) gene polymorphisms and hypertension in postmenopausal women.
  
  
  METHODS
  The relationship of two polymorphisms (rs944050 and rs4986938) with hypertension was examined in 71 postmenopausal women with hypertension and 50 healthy age-matched controls.
  
  
  RESULTS
  In hypertension and control groups, the ERβ allelic frequencies of A and G were 0.500, 0.500, 0.540, 0.460; 0.077, 0.923, 0.170, 0.830 respectively. The genotypic distributions of both polymorphisms stayed within Hardy-Weinberg equilibrium. For polymorphism rs4986938, statistical difference existed between the wild-type genotype and a combination of heterozygous and homozygous variant genotypes (P < 0.05). The variant allele A of rs4986938 in ERβ gene decreased the risk of hypertension (OR = 0.41, 95%CI 0.18-0.92).
  
  
  CONCLUSIONS
  The polymorphism rs4986938 in ERβ gene was associated with an elevated risk of hypertension in Chinese Han postmenopausal women.
authors.affiliation: Zhongnan Hospital, Wuhan University, Wuhan 430071, China.
authors.forename: Jia-wei
authors.initials: JW
authors.lastname: Xin
authors.forename: Jun-jian
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Yong-zhe
authors.initials: YZ
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Xiong
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D012307:Risk Factors
chemical_list: D047629:Estrogen Receptor beta