title: Lactobacillus plantarum LG42 isolated from gajami sik-hae decreases body and fat pad weights in diet-induced obese mice.
abstract: OBJECTIVE
  This study investigated the antiobesity effect of lactic acid bacteria (Lactobacillus plantarum LG42) isolated from gajami sik-hae.
  
  
  RESULTS
  Male C57BL/6J mice were divided into four groups (n = 10); NDC (normal diet & DW), HDC (high-fat diet & DW), LGLAB (high-fat diet & Lactobacillus plantarum LG42, 1 × 10(7) CFU per mouse), HGLAB (high-fat diet & L. plantarum LG42, 1 × 10(9) CFU per mouse). After 12 weeks, GLAB supplemented groups showed lower body weight, with a significant reduction in epididymal and back fat. Serum and hepatic triglyceride, serum insulin and leptin levels were significantly lowered in GLAB supplemented groups. The hepatic mRNA expression of PPARα and CPT-I were significantly increased in GLAB groups, whereas the level of ACC, SREBP-1 and LXRα were significantly decreased in GLAB groups compared with HDC group. Additionally, GLAB reduces the expression of PPARγ in the epididymal adipose tissue resulting in inhibition of genes regulated by PPARγ.
  
  
  CONCLUSIONS
  These results suggest that the Lactobacillus plantarum LG42 has antiobesity effects in high-fat-diet-induced obese mice.
  
  
  CONCLUSIONS
  These results may contribute to nutraceutical and food industries in developing functional food and probiotics based therapies for the treatment and prevention of obesity.
authors.affiliation: Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, Korea; Jeonju Makgeolli Research Center, Chonbuk National University, Jeonju, Korea.
authors.forename: J-E
authors.initials: JE
authors.lastname: Park
authors.forename: S-H
authors.initials: SH
authors.lastname: Oh
authors.forename: Y-S
authors.initials: YS
authors.lastname: Cha
keywords: Lactobacillus plantarum LG42; antiobesity; gajami sik-hae; high-fat diet