title: Decoding the pathophysiology and the genetics of multiple myeloma to identify new therapeutic targets.
abstract: In recent years, significant progress has been achieved in the characterization of the transcriptional profiles, gene mutations and structural chromosomal lesions in myeloma cells. These studies have identified many candidate therapeutic targets, which are recurrently deregulated in myeloma cells. However, these targets do not appear, at least individually, to represent universal driver(s) of this disease. Furthermore, evaluation of these recurrent lesions does not suggest that they converge to a single molecular pathway. Detailed integration of molecular and functional data for these candidate targets and pathways will hopefully dissect which of them play more critical roles for each of the different individual molecular defined subtypes of this disease. This review focuses on how recent updates in our understanding of myeloma pathogenesis and molecular characterization may impact ongoing and future efforts to develop new therapeutics for this disease.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA; Division of Hematology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Thai Red Cross Society, Bangkok, Thailand.
authors.forename: Panisinee
authors.initials: P
authors.lastname: Lawasut
authors.forename: Richard W J
authors.initials: RW
authors.lastname: Groen
authors.forename: Eugen
authors.initials: E
authors.lastname: Dhimolea
authors.forename: Paul G
authors.initials: PG
authors.lastname: Richardson
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Anderson
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Mitsiades
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D009154:Mutation; D017422:Sequence Analysis, DNA; D015398:Signal Transduction
chemical_list: D006657:Histones; D035683:MicroRNAs