title: D-psicose increases energy expenditure and decreases body fat accumulation in rats fed a high-sucrose diet.
abstract: We investigated the anti-obesity effects of D-psicose by increasing energy expenditure in rats pair-fed the high-sucrose diet (HSD). Wistar rats were divided into two dietary groups: HSD containing 5% cellulose (C) and 5% d-psicose (P). The C dietary group was further subdivided into two groups: rats fed the C diet ad libitum (C-AD) and pair-fed the C diet along with those in the P group (C-PF). Resting energy expenditure during darkness and lipoprotein lipase activity in the soleus muscle were significantly higher in the P group than in the C-PF group. Serum levels of glucose, leptin and adiponectin; glucose-6-phosphate dehydrogenase activities in the liver and perirenal adipose tissue; and body fat accumulation were all significantly lower in the P group than in the C-PF group. The anti-obesity effects of D-psicose could be induced not only by suppressing lipogenic enzyme activity but also by increasing EE in rats.
authors.affiliation: Faculty of Agriculture, Kagawa University , 2393 Ikenobe, Miki, Kita , Kagawa , Japan and.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ochiai
authors.forename: Kana
authors.initials: K
authors.lastname: Onishi
authors.forename: Takako
authors.initials: T
authors.lastname: Yamada
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Iida
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Matsuo
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D004032:Diet; D019422:Dietary Sucrose / Q000009:adverse effects*; D004734:Energy Metabolism / Q000187:drug effects*; D005632:Fructose / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019440:Anti-Obesity Agents; D019422:Dietary Sucrose; C003243:psicose; D005632:Fructose