title: New therapeutic alternatives for the management of dyslipidemia.
abstract: Hypercholesterolemia affects over 34 million adults in the United States and is a major cause of coronary heart disease (CHD). Conventional therapies, such as statins, have demonstrated their ability to improve clinical end points and decrease morbidity and mortality in patients with CHD. Lomitapide (Juxtapid(®)), mipomersen (Kynamro(®)), and icosapent (Vascepa(®)) are 3 novel agents approved by the US Food and Drug Administration in the past 2 years, which offer new lipid-lowering treatment options with unique pharmacology.
authors.affiliation: St. John's University, College of Pharmacy and Health Sciences, Department of Clinical Pharmacy Practice, Queens, New York, USA and Long Island Jewish Medical Center, Department of Pharmacy, New Hyde Park, New York, USA.
authors.forename: Manouchkathe
authors.initials: M
authors.lastname: Cassagnol
authors.forename: Danielle
authors.initials: D
authors.lastname: Ezzo
authors.forename: Priti N
authors.initials: PN
authors.lastname: Patel
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D017277:Drug Approval; D015118:Eicosapentaenoic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D009841:Oligonucleotides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology; D014486:United States Food and Drug Administration
chemical_list: D000924:Anticholesteremic Agents; C473731:BMS201038; D001562:Benzimidazoles; D009841:Oligonucleotides; C035276:eicosapentaenoic acid ethyl ester; C524142:mipomersen; D015118:Eicosapentaenoic Acid
keywords: ezetimibe/atorvastatin; hypercholesterolemia; icosapent; lomitapide; mipomersen