title: NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese.
abstract: The innate immunity and inflammatory response plays an important role in AD pathogenesis. Recently, a wealth of information linking the activation of NLRP3 inflammasome to Alzheimer's disease (AD) pathogenesis has emerged. Considering the pivotal role of NLRP3 in the inflammatory process and in AD, we hypothesized that variations in NLRP3 gene may also affect susceptibility to AD. Three selected functional single-nucleotide polymorphisms (SNPs) in NLRP3 gene (rs2027432, rs10754558, rs35829419) were genotyped in 1133 late-onset AD (LOAD) patients and 1159 healthy controls in a large Northern Han Chinese population. Among them, the 5'-flanking rs2027432 polymorphism seemed to be most associated with LOAD risk even after adjusting for age, gender, and ApoE ε4 status. For rs10754558, the genotype frequency differed significantly only in ApoE ε4 carriers. On the other hand, the minor A allele of rs35829419 (Q705K) polymorphism appeared to exert a protective effect against the development of LOAD. Our data support the notion that genetic variation in NLRP3 gene may contribute to LOAD risk in Northern Han Chinese.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, China.
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Tan
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Teng
authors.initials: T
authors.lastname: Jiang
authors.forename: Xi-Chen
authors.initials: XC
authors.lastname: Zhu
authors.forename: Hui-Fu
authors.initials: HF
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human
keywords: Alzheimer's disease; Association study; NLRP3; Polymorphism; Susceptibility