title: DGIdb: mining the druggable genome.
abstract: The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/.
authors.affiliation: 1] The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [3].
authors.forename: Malachi
authors.identifier: 000000026388446X
authors.initials: M
authors.lastname: Griffith
authors.forename: Obi L
authors.initials: OL
authors.lastname: Griffith
authors.forename: Adam C
authors.initials: AC
authors.lastname: Coffman
authors.forename: James V
authors.initials: JV
authors.lastname: Weible
authors.forename: Josh F
authors.initials: JF
authors.lastname: McMichael
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Spies
authors.forename: James
authors.initials: J
authors.lastname: Koval
authors.forename: Indraniel
authors.initials: I
authors.lastname: Das
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Callaway
authors.forename: James M
authors.initials: JM
authors.lastname: Eldred
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Miller
authors.forename: Janakiraman
authors.initials: J
authors.lastname: Subramanian
authors.forename: Ramaswamy
authors.initials: R
authors.lastname: Govindan
authors.forename: Runjun D
authors.initials: RD
authors.lastname: Kumar
authors.forename: Ron
authors.initials: R
authors.lastname: Bose
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Jason R
authors.initials: JR
authors.lastname: Walker
authors.forename: David E
authors.initials: DE
authors.lastname: Larson
authors.forename: David J
authors.initials: DJ
authors.lastname: Dooling
authors.forename: Scott M
authors.initials: SM
authors.lastname: Smith
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Ley
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Mardis
authors.forename: Richard K
authors.initials: RK
authors.lastname: Wilson
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D057225:Data Mining / Q000379:methods*; D030541:Databases, Genetic; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D005786:Gene Expression Regulation / Q000187:drug effects; D014644:Genetic Variation; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics; D009154:Mutation; D012984:Software; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000970:Antineoplastic Agents