title: Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of Leishmania amazonensis.
abstract: In this research, a series of substituted 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
authors.affiliation: Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21040-900, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: dos Santos Faiões
authors.forename: Leonor L
authors.initials: LL
authors.lastname: Leon
authors.forename: Marilene M
authors.initials: MM
authors.lastname: Canto-Cavalheiro
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Torres-Santos
authors.forename: Alice M R
authors.initials: AM
authors.lastname: Bernardino
authors.forename: Percilene F
authors.initials: PF
authors.lastname: Vegi
authors.forename: Maurício S
authors.initials: MS
authors.lastname: dos Santos
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D013777:Tetrazoles
keywords: Leishmania amazonensis; antileishmanial activity; tetrazole derivatives