title: NF-κB: a coordinator for epigenetic regulation by MLL.
abstract: NF-κB is involved in a variety of biological processes, including cancer development. In this issue of Cancer Cell, Kuo et al. show the essential role for IKK/NF-κB signaling in epigenetic regulation by MLL oncoproteins to maintain leukemia stem cells.
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Susumu
authors.initials: S
authors.lastname: Goyama
authors.forename: James C
authors.initials: JC
authors.lastname: Mulloy
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015973:Gene Expression Regulation, Leukemic; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000502:physiology*; D016328:NF-kappa B / Q000378:metabolism*
chemical_list: C497422:KMT2A protein, human; D016328:NF-kappa B; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase