title: Reduced serum retinol-binding protein levels in patients with de novo acute myeloid leukaemia.
abstract: Retinol-binding protein (RBP) has been used as a nutritional index for children with acute myeloid leukaemia (AML) in previous studies. However, no studies have yet examined RBP levels in AML patients from all age groups. In this study, AML patients presented with lower RBP concentrations than healthy control subjects and patients with benign haematopathies. A negative association was observed between serum RBP level and peripheral white blood cell count in M4 and M5 AML patients. Moreover, patients carrying the FLT3-ITD mutation and young patients had lower RBP levels than those lacking this mutation and elderly patients. In conclusion, these observations suggest that aberrant retinol levels may be associated with AML.
authors.affiliation: The First Hospital, Jilin University, Changchun, China.
authors.forename: Long
authors.initials: L
authors.lastname: Su
authors.forename: Sujun
authors.initials: S
authors.lastname: Gao
authors.forename: YeHui
authors.initials: Y
authors.lastname: Tan
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: XiaoLiang
authors.initials: X
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.forename: Hai
authors.initials: H
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012177:Retinol-Binding Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012177:Retinol-Binding Proteins