title: Plerixafor on-demand combined with chemotherapy and granulocyte colony-stimulating factor: significant improvement in peripheral blood stem cells mobilization and harvest with no increase in costs.
abstract: To date, no prospective study on Plerixafor 'on-demand' in combination with chemotherapy and granulocyte colony-stimulating factor (G-CSF) has been reported. We present an interim analysis of the first prospective study in which Plerixafor was administered on-demand in patients affected by multiple myeloma and lymphoma who received high dose cyclophosphamide or DHAP (dexamethasone, cytarabine, cisplatin) plus G-CSF to mobilize peripheral blood stem cells (PBSC). One hundred and two patients were evaluable for response. A cohort of 240 patients receiving the same mobilizing chemotherapy was retrospectively studied. Failure to mobilize CD34(+) cells in peripheral blood was reduced by 'on-demand' strategy compared to conventional mobilization; from 13·0 to 3·0% (P = 0·004). Failure to harvest CD34(+) cells 2 × 10(6) /kg decreased from 20·9 to 4·0% (P = 0·0001). The on-demand Plerixafor strategy also resulted in a lower rate of mobilization failure (P = 0·03) and harvest failure (P = 0·0008) when compared to a 'bias-adjusted set of controls'. Evaluation of economic costs of the two strategies showed that the overall cost of the two treatments were comparable when salvage mobilizations were taken into account. When in combination with cyclophosphamide or DHAP plus G-CSF, the 'on-demand' use of Plerixafor showed, in comparison to conventionally treated patients, a significant improvement in mobilization of PBSC with no increase in overall cost.
authors.affiliation: Programma di Trapianto Emopoietico, Azienda Ospedaliera Policlinico Vittorio Emanuele, Catania, Italy; Istituto Oncologico del Mediterraneo, Viagrande, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Milone
authors.forename: Massimo
authors.initials: M
authors.lastname: Martino
authors.forename: Andrea
authors.initials: A
authors.lastname: Spadaro
authors.forename: Salvatore
authors.initials: S
authors.lastname: Leotta
authors.forename: Annalia
authors.initials: A
authors.lastname: Di Marco
authors.forename: Potito
authors.initials: P
authors.lastname: Scalzulli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cupri
authors.forename: Valentina
authors.initials: V
authors.lastname: Di Martina
authors.forename: Elena
authors.initials: E
authors.lastname: Schinocca
authors.forename: Eleonora
authors.initials: E
authors.lastname: Spina
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tripepi
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001596:Benzylamines; D001781:Blood Component Removal / Q000191:economics / Q000379:methods; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000191:economics; D019650:Hematopoietic Stem Cell Mobilization / Q000191:economics / Q000379:methods*; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000191:economics; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000191:economics / Q000379:methods*; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: apheresis harvest; peripheral blood stem cell mobilization; plerixafor