title: Serum resistin levels: a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis.
abstract: Our latest studies demonstrated the potential role of adipocytokines, including adiponectin, visfatin, retinol binding protein-4, and apelin, in the pathogenesis of systemic sclerosis (SSc). Given that resistin is another member of adipocytokines with pro-inflammatory and pro-angiogenic properties, we measured serum resistin levels by enzyme-linked immunosorbent assay in 52 SSc and 19 control subjects and evaluated their clinical correlation. Since serum resistin levels greatly and inversely correlated with estimated glomerular filtration rate in SSc patients with renal dysfunction [r = -0.78, p < 0.05 (n = 9)], we evaluated the clinical correlation of serum resistin levels in SSc patients with normal renal function (n = 43). Although serum resistin levels were comparable between diffuse cutaneous SSc (n = 22), limited cutaneous SSc (n = 21), and control subjects (n = 19) [median (25-75 percentiles); 18.7 ng/ml (13.3-48.0), 23.3 ng/ml (12.9-54.1), and 22.9 ng/ml (9.4-36.7), respectively], the prevalence of elevated right ventricular systolic pressure (RVSP) was significantly higher in SSc patients with elevated serum resistin levels than in those with normal levels [67 % (4/6) vs. 16 % (6/37), p < 0.05], and serum resistin levels were significantly increased in SSc patients with elevated RVSP (n = 10) as compared to those with normal RVSP (n = 33) [52.1 ng/ml (20.8-117.5) vs. 18.5 ng/ml (12.2-46.2), p < 0.05]. Thus, serum resistin levels may serve as a useful marker for pulmonary vascular involvement in SSc, suggesting a possible contribution of resistin to the pathogenesis of pulmonary arterial hypertension associated with SSc.
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Masui
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Kaname
authors.initials: K
authors.lastname: Akamata
authors.forename: Naohiko
authors.initials: N
authors.lastname: Aozasa
authors.forename: Shinji
authors.initials: S
authors.lastname: Noda
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ichimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Toyama
authors.forename: Hayakazu
authors.initials: H
authors.lastname: Sumida
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kuwano
authors.forename: Koichi
authors.initials: K
authors.lastname: Yanaba
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tada
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kadono
mesh_terms: D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology*; D052243:Resistin / Q000097:blood*; D045743:Scleroderma, Diffuse / Q000097:blood / Q000150:complications / Q000175:diagnosis; D045745:Scleroderma, Limited / Q000097:blood / Q000150:complications / Q000175:diagnosis; D012595:Scleroderma, Systemic / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015854:Up-Regulation; D016278:Ventricular Function, Right; D017725:Ventricular Pressure
chemical_list: D015415:Biomarkers; D052243:Resistin