title: Anal carcinoma and HIV infection: is it time for screening?
abstract: A 38-year-old white man had a 10-year history of human immunodeficiency virus (HIV) infection (A3), with no episodes of opportunistic diseases and in good immunologic recovery (CD4 cell count: 450 and indetectable HIV viral load) while on HAART. He presented with a two-month history of mild anal symptoms, including pruritus and episodic bleeding. He referred past episodes of anal warts, self-treated with several topical compounds, all proven unsuccessful. Perianal examination showed erythema and scratching. A 0.5cm sized tumor, with infiltration at the base was detected on digital exam, located at 15mm from the anal margin. Local biopsy driven by high-resolution anuscopy (AAR) yielded a final diagnosis of infiltrative epidermoid carcinoma. Might that neoplasia have been prevented?
authors.affiliation: Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España. Electronic address: pherranzp@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Herranz-Pinto
authors.affiliation: Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Sendagorta-Cudós
authors.affiliation: Unidad VIH, Hospital Universitario La Paz, Madrid, España.
authors.forename: J I
authors.initials: JI
authors.lastname: Bernardino-de la Serna
authors.affiliation: Unidad VIH, Hospital Universitario La Paz, Madrid, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Peña-Sánchez de Rivera
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000473:pathology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001005:Anus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D003218:Condylomata Acuminata / Q000150:complications; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male
keywords: Anal carcinoma; Anoscopia; Anoscopy; Carcinoma anal; Citology; Citología; Cribado; Diagnosis; Diagnóstico; Human immunodeficiency virus; Human papilloma virus; Intraepithelial neoplasia; Neoplasia intraepitelial; Screening; Virus de la inmunodeficiencia humana; Virus del papiloma humano