title: Modulation of individual components of gastric motor response to duodenal glucose.
abstract: OBJECTIVE
  To evaluate individual components of the antro-pyloro-duodenal (APD) motor response to graded small intestinal glucose infusions in healthy humans.
  
  
  METHODS
  APD manometry was performed in 15 healthy subjects (12 male; 40 ± 5 years, body mass index 26.5 ± 1.6 kg/m(2)) during four 20-min intraduodenal infusions of glucose at 0, 0.5, 1.0 and 1.5 kcal/min, in a randomised double-blinded fashion. Glucose solutions were infused at a rate of 1 mL/min and separated by 40-min "wash-out" period. Data are mean ± SE. Inferential analyses are repeated measure analysis of variance with Bonferroni post-hoc testing.
  
  
  RESULTS
  At 0 kcal/min frequency of pressure waves were: antrum (7.5 ± 1.8 waves/20 min) and isolated pyloric pressure waves (IPPWs) (8.0 ± 2.3 waves/20 min) with pyloric tone (0.0 ± 0.9 mmHg). Intraduodenal glucose infusion acutely increased IPPW frequency (P < 0.001) and pyloric tone (P = 0.015), and decreased antral wave frequency (P = 0.007) in a dose-dependent fashion. A threshold for stimulation was observed at 1.0 kcal/min for pyloric phasic pressure waves (P = 0.002) and 1.5 kcal/min for pyloric tone and antral contractility.
  
  
  CONCLUSIONS
  There is hierarchy for the activation of gastrointestinal motor responses to duodenal glucose infusion. An increase in IPPWs is the first response observed.
authors.affiliation: Adam M Deane, Marianne J Chapman, Discipline of Acute Care Medicine, University of Adelaide, Adelaide 5000, South Australia, Australia.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Deane
authors.forename: Laura K
authors.initials: LK
authors.lastname: Besanko
authors.forename: Carly M
authors.initials: CM
authors.lastname: Burgstad
authors.forename: Marianne J
authors.initials: MJ
authors.lastname: Chapman
authors.forename: Michael
authors.initials: M
authors.lastname: Horowitz
authors.forename: Robert J L
authors.initials: RJ
authors.lastname: Fraser
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D004311:Double-Blind Method; D004386:Duodenum / Q000294:innervation* / Q000378:metabolism*; D025461:Feedback, Physiological; D005260:Female; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000378:metabolism*; D005769:Gastrointestinal Motility; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure; D013021:South Australia; D013270:Stomach / Q000294:innervation*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D005947:Glucose
keywords: Antral; Blood glucose; Duodenum; Gastrointestinal motility; Glucose; Manometry; Motor activity; Pyloric