title: Prolonged vitamin D intoxication: presentation, pathogenesis and progress.
abstract: Vitamin D toxicity from unactivated vitamin D (calciferol) therapy is currently a rare cause of hypercalcaemia. However, the frequency of this event may increase as high-dose unactivated vitamin D preparations become available. Prolonged vitamin D toxicity can cause reversible hypercalcaemia and partially reversible renal impairment. Parathyroid hormone may not be suppressed with unactivated vitamin D toxicity, especially if renal disease coexists.
authors.affiliation: Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital, Perth, Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: D A
authors.initials: DA
authors.lastname: Bell
authors.forename: M J
authors.initials: MJ
authors.lastname: Crooke
authors.forename: N
authors.initials: N
authors.lastname: Hay
authors.forename: P
authors.initials: P
authors.lastname: Glendenning
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D000368:Aged; D002762:Cholecalciferol / Q000008:administration & dosage / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D002762:Cholecalciferol
keywords: acute renal injury; hypercalcaemia; vitamin D intoxication