title: Pathomorphological analysis of the pancreaticoduodenal organs in experimental pancreonecrosis induced by trypsin injection.
abstract: Acute experimental pancreatitis induced by injection of trypsin into the pancreatic tissue exhibited characteristics of fulminant hemorrhagic pancreonecrosis (intense exudation of interlobular stroma, massive plasmo- and hemorrhages, foci of acinar cell autolysis involving by the end of day 1 an appreciable portion of the organ with formation of fields of necrosis and hemorrhagic imbibition of the glandular parenchyma, virtually completely without demarcation cellular reaction). Marked microcirculatory disorders and degenerative and necrobiotic changes in the duodenal mucosa and liver reflected the polyorgan nature of the pathological process. This model of hemorrhagic pancreonecrosis corresponded to the most severe forms of this conditions observed clinically.
authors.affiliation: Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
authors.forename: M A
authors.initials: MA
authors.lastname: Bakarev
authors.forename: A V
authors.initials: AV
authors.lastname: Vasilyev
authors.forename: S I
authors.initials: SI
authors.lastname: Protsenko
mesh_terms: D000818:Animals; D001329:Autolysis / Q000139:chemically induced; D004195:Disease Models, Animal; D004386:Duodenum / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D014357:Trypsin / Q000633:toxicity
chemical_list: D014357:Trypsin