title: Moisturizing effect of topical cosmetic products applied to dry skin.
abstract: One of the complications of "diabetes mellitus" is termed diabetic foot syndrome, the first symptoms of which include changes in the skin's condition and properties. The skin becomes dehydrated, dry, and prone to excessive formation of the horny layer, its barrier function becoming weakened. This function can be restored by applying suitable cosmetic excipients containing active substances. The aim of this study was to evaluate and compare the effects of commercially available cosmetic products (CPs) designed for the care of diabetic foot, through a group of selected volunteers using noninvasive bioengineering methods. Statistical surveys (p < 0.05) evaluated these CPs as regards to their hydration effect and barrier properties. Special attention was devoted to CPs with the declared content of 10% urea, and that the influence of this preparation's ability to hydrate and maintain epidermal water in the epidermis was confirmed.
authors.affiliation: Department of Fat, Tenside, and Cosmetics Technology ( J.P., J.P., P.V., R.J.), and Department of Polymer Engineering (P.M.), Tomas Bata University in Zlin, 762 72 Zlin, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Polaskova
authors.forename: Jana
authors.initials: J
authors.lastname: Pavlackova
authors.forename: Pavlina
authors.initials: P
authors.lastname: Vltavska
authors.forename: Pavel
authors.initials: P
authors.lastname: Mokrejs
authors.forename: Rahula
authors.initials: R
authors.lastname: Janis
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003358:Cosmetics / Q000008:administration & dosage* / Q000737:chemistry; D017719:Diabetic Foot / Q000473:pathology*; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005079:Excipients / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D005990:Glycerol / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008875:Middle Aged; D010539:Permeability; D012869:Skin Absorption; D014508:Urea / Q000008:administration & dosage* / Q000737:chemistry; D014867:Water / Q000378:metabolism*
chemical_list: D003358:Cosmetics; D005079:Excipients; D014867:Water; D014508:Urea; D005990:Glycerol