title: [Guiding value of brain tissue oxygenation plus intracranial pressure monitoring in severe traumatic brain injury patients].
abstract: OBJECTIVE
  To elucidate the effectiveness of brain tissue oxygenation (PbtO2) plus intracranial pressure (ICP) monitoring and targeted therapy in patients of severe traumatic brain injury (TBI).
  
  
  METHODS
  A total of 46 patients with severe TBI (Glasgow coma scale, GCS scale ≤ 8) admitted at Jiangyin People's Hospital from June 2009 to June 2012 were divided randomly into 2 groups and evaluated prospectively.Patients undergoing ICP plus PbtO2 monitoring were compared with controls with ICP monitoring alone.Therapies of both patient groups were attempted to maintain an ICP < 20 mm Hg and a cerebral perfusion pressure (CPP) ≥ 60 mm Hg.Among those with PbtO2 monitoring, oxygenation was maintained at a level of ≥ 20 mm Hg.The scores of Glasgow outcome scale (GOS) were compared between two groups at Month 6 post-injury.
  
  
  RESULTS
  The mean daily ICP and CPP levels were similar in each group.The mortality rate was 21.7% in patients with ICP monitoring alone and the favorable outcome rate was 47.8%.However, those receiving combined management had a significantly reduced mortality rate of 8.7% and good outcome rate of 65.2% (P < 0.05).
  
  
  CONCLUSIONS
  The combined use of both ICP and PbtO2 may be associated with reduced mortality and improved outcome in patients with severe TBI.
authors.affiliation: Department of Neurosurgery, Jiangyin People's Hospital, Jiangyin 214400, China.
authors.forename: Qi-ping
authors.initials: QP
authors.lastname: Wang
authors.forename: Shi-ming
authors.initials: SM
authors.lastname: Zhang
authors.forename: Heng
authors.initials: H
authors.lastname: Gao
authors.forename: Han-rong
authors.initials: HR
authors.lastname: Na
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010092:Oximetry; D011446:Prospective Studies; D055815:Young Adult