title: A pilot study on the combined use of letrozole, mifepristone and misoprostol in termination of first trimester pregnancy up to 9 weeks' gestation.
abstract: OBJECTIVE
  To assess the feasibility of adding letrozole to the standard regimen of mifepristone and misoprostol for termination of pregnancy up to 63 days.
  
  
  METHODS
  We recruited 50 subjects who had requested legal termination of pregnancy up to 63 days. Medical abortion was performed with a singe dose of 200 mg mifepristone and 10 mg of letrozole daily for 3 days followed by 800 mcg vaginal misoprostol.
  
  
  RESULTS
  The complete abortion rate was 98% (95% CI: 94-100%). The median induction-to-abortion interval of the regimen was 5.1 h (range 1.2-56 h). No serious adverse effects were reported.
  
  
  CONCLUSIONS
  The results of this pilot study suggest that a regimen of mifepristone, letrozole and misoprostol is associated with a high complete abortion rate without major adverse events.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: jchai@hkucc.hku.hk.
authors.forename: Joyce
authors.initials: J
authors.lastname: Chai
authors.forename: Pak-Chung
authors.initials: PC
authors.lastname: Ho
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage; D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D047072:Aromatase Inhibitors / Q000008:administration & dosage; D005260:Female; D006801:Humans; D000077289:Letrozole; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D009570:Nitriles / Q000008:administration & dosage*; D010865:Pilot Projects; D011247:Pregnancy; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D016595:Misoprostol; D015735:Mifepristone; D000077289:Letrozole
keywords: Letrozole; Mifepristone; Misoprostol; Termination of pregnancy