title: Revisiting the TRAK family of proteins as mediators of GABAA receptor trafficking.
abstract: γ-Aminobutyric acid type A (GABAA) receptor interacting factor-1 (GRIF-1) was originally discovered as a result of studies aiming to find the elusive GABAA receptor clustering protein. It was identified as a GABAA receptor associated protein by virtue of its specific interaction with the GABAA receptor β2 subunit intracellular loop in a yeast two-hybrid screen of a rat brain cDNA library. Further work however, established that GRIF-1, now known as trafficking kinesin protein 2 (TRAK2), is a member of the TRAK family of kinesin adaptor proteins. A pivotal role for TRAK1 and TRAK2 in the transport of mitochondria is well recognized. Notwithstanding this progress, there is a body of evidence that still supports a role for TRAKs in the intracellular transport of GABAA receptors. This is critically reviewed in this article.
authors.affiliation: University College London School of Pharmacy, 29/39 Brunswick Square, London, WC1N 1AX, UK, anne.stephenson@ucl.ac.uk.
authors.forename: F Anne
authors.initials: FA
authors.lastname: Stephenson
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D051379:Mice; D021381:Protein Transport; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D020798:Two-Hybrid System Techniques
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D011963:Receptors, GABA-A