title: Lipid transport and metabolism in healthy and osteoarthritic cartilage.
abstract: Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.
authors.affiliation: Osteoarticular Pathology Laboratory, IIS Fundación Jiménez Díaz, Madrid 28040, Spain. amanda.villalvilla@fjd.es.
authors.forename: Amanda
authors.initials: A
authors.lastname: Villalvilla
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Gómez
authors.forename: Raquel
authors.initials: R
authors.lastname: Largo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Herrero-Beaumont
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002356:Cartilage / Q000378:metabolism*; D019902:Chondrocytes / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D010003:Osteoarthritis / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D058570:TOR Serine-Threonine Kinases