title: Translational issues in targeting brown adipose tissue thermogenesis for human obesity management.
abstract: The recent advancements in unraveling novel mechanisms that control the induction, (trans)differentiation, proliferation, and thermogenic activity and capacity of brown adipose tissue (BAT), together with the application of imaging techniques for human BAT visualization, have generated optimism that these advances will provide novel strategies for targeting BAT thermogenesis, leading to efficacious and safe obesity therapies. This paper first provides an overview of landmark events of the past few decades that have been driving the search for pharmaceutical and nutraceutical compounds that would increase BAT thermogenesis for obesity management. It then addresses issues about what could be expected from an ideal thermogenic antiobesity approach, in particular to what extent daily energy expenditure will need to increase in order to achieve long-term weight loss currently achievable only through bariatric surgery, and whether the human body will have enough thermogenic capacity to reach this target weight loss by future therapies focused on BAT.
authors.affiliation: Department of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.
authors.forename: Abdul G
authors.initials: AG
authors.lastname: Dulloo
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects / Q000379:methods / Q000639:trends; D009765:Obesity / Q000188:drug therapy*; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000302:isolation & purification; D022722:Thermogenesis / Q000187:drug effects*; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends
chemical_list: D019440:Anti-Obesity Agents; D004364:Pharmaceutical Preparations
keywords: brown fat; diabetes; energy expenditure; fat oxidation; obesity; thermogenesis