title: Effects of microdermabrasion on skin rejuvenation.
abstract: BACKGROUND
  Microdermabrasion is a surface treatment, noninvasive, which uses a negative pressure and drives programmable inert microcrystals on the skin, causing an exfoliation.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effects of application of microdermabrasion in human skin rejuvenation.
  
  
  METHODS
  Eleven women who were undergoing abdominoplasty were considered. An area of 25 cm² in the umbilicus to the right was conditioned with microcrystals of Al₂O₃ in maximum flow, negative pressure of 200 mmHg and total of 8 past, the left side being used as control. The number of sessions ranged from one to five, with weekly intervals, and timing of sample collection ranged from 0 to 132 days. Samples were fixed in 10% formaldehyde in phosphate buffer and were evaluated histologically.
  
  
  RESULTS
  A mild to marked hyperpigmentation was observed and remained for a variable period. Histological findings suggest an improvement in the epidermal layer with increased thickness and reestablishing their interdigitations in the dermis initially observed an increase in collagen synthesis. The analysis showed a late stay of epidermal changes, which did not occur in the dermis.
  
  
  CONCLUSIONS
  Under the conditions and parameters used in this work, the microdermabrasion had a positive skin structure, showing that a viable resource in promoting skin rejuvenation.
authors.affiliation: Department of Physiotherapy, Institute of Health Sciences, Federal University of Triângulo Mineiro , Uberaba , Brazil.
authors.forename: Mariane
authors.initials: M
authors.lastname: Fernandes
authors.forename: Nanci Mendes
authors.initials: NM
authors.lastname: Pinheiro
authors.forename: Virgínia Oliveira
authors.initials: VO
authors.lastname: Crema
authors.forename: Adriana Clemente
authors.initials: AC
authors.lastname: Mendonça
mesh_terms: D061645:Abdominoplasty; D000328:Adult; D003094:Collagen / Q000096:biosynthesis; D003869:Dermabrasion / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012060:Rejuvenation / Q000502:physiology*; D012867:Skin / Q000033:anatomy & histology* / Q000378:metabolism; D015595:Skin Aging / Q000502:physiology*; D012879:Skin Physiological Phenomena
chemical_list: D003094:Collagen