title: Frequency of HLA-A 03 associates with HIV-1 infection in a Chinese cohort.
abstract: During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1. However, AIDS progression in the former blood donors (FBDs) is various. The aim of this study is to assess human leukocyte antigen (HLA) class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART naïve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared with HIV-seropositive group, the frequency of HLA-A 03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes, detrimental effect of HLA Bw6/ Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. This study provides novel evidence on HLA class I allele distribution and association of HLA-A 03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression.
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
authors.forename: Weilun
authors.initials: W
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Kunxue
authors.initials: K
authors.lastname: Hong
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Su
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.forename: Jianqin
authors.initials: J
authors.lastname: Xu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.forename: Yimin
authors.initials: Y
authors.lastname: Shao
authors.forename: Dexian
authors.initials: D
authors.lastname: Zheng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D015791:HLA-A3 Antigen / Q000235:genetics*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014766:Viremia / Q000235:genetics
chemical_list: D015791:HLA-A3 Antigen