title: Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment.
abstract: Because contaminants and nutrients always coexist in fish, the risk from contaminants and the benefit from nutrients, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are also concomitant via fish consumption. To investigate the risk and benefit via fish consumption, concentrations of dichlorodiphenyltrichloroethane and its metabolites (DDTs), and hexachlorocyclohexanes (HCHs) in the whole- and portion-muscles of fish from Taihu Lake, China, were measured. Based on the contaminant data and nutrients from our previous study, and the associated risk and benefit via fish consumption were estimated. The concentrations of DDTs and HCHs in the whole-muscles ranged from 7.8 × 10² to 3.4×10³ pg g⁻¹ ww, and from 67.3 to 300 pg g⁻¹ ww, respectively. Of DDTs and HCHs measured, p,p'-DDE and β-HCH were respectively the most abundant pesticides. The composition profiles of DDTs and HCHs suggested that the pesticides were mainly historical residues. The benefit-risk quotient (BRQ) of EPA+DHA vs. POPs (persistent organic pollutants including data of DDTs, HCHs, and those of polychlorinated biphenyls and polybrominated diphenyl ethers cited from our previous study) via consumption of fish from Taihu Lake was calculated. As a result, to achieve the recommended EPA+DHA intake of 250 mg d⁻¹ for a healthy adult, the consumption of most fish species from the lake can cause cancer and non-cancer risks. However, the fish consumption at the rates of 44.9 g d⁻¹ by Chinese would not lead to the risks for most of the species. The results also suggested that the risk of consuming silver carp was generally lower than other fish species, and those of dorsal muscles were lower than ventral and tail muscles.
authors.affiliation: Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Wang
authors.forename: Yingxin
authors.initials: Y
authors.lastname: Yu
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Dongping
authors.initials: D
authors.lastname: Zhang
authors.forename: Shaohuan
authors.initials: S
authors.lastname: Zhang
authors.forename: Minghong
authors.initials: M
authors.lastname: Wu
mesh_terms: D000818:Animals; D002681:China; D003634:DDT / Q000032:analysis / Q000633:toxicity*; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis / Q000633:toxicity; D004032:Diet; D004281:Docosahexaenoic Acids / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000032:analysis / Q000633:toxicity*; D006801:Humans; D060106:Lakes; D009132:Muscles / Q000378:metabolism; D010575:Pesticides / Q000032:analysis / Q000633:toxicity*; D018570:Risk Assessment; D035501:Uncertainty
chemical_list: D010575:Pesticides; D004281:Docosahexaenoic Acids; D003633:Dichlorodiphenyl Dichloroethylene; D001556:Hexachlorocyclohexane; D015118:Eicosapentaenoic Acid; D003634:DDT
keywords: Benefit–risk assessment; Fish; Organochlorine pesticide; Persistent organic pollutant; Taihu Lake