title: Accumulation and elimination of photosens and protoporphyrin IX by different types of mesenchymal cells.
abstract: We studied the kinetics of accumulation and elimination of Photosens and accumulation of protoporphyrin IX in macrophages, endothelial cells, and mesenchymal stromal cells of the human adipose tissue in vitro. In all studied cells, the dynamics of Photosens accumulation was described by a multiphase curve and the maximum accumulation of the dye was observed during the second exponential phase. Elimination of Photosens did not depend on the cell function. Accumulation of protoporphyrin IX differed considerably in different cells: it was maximum in mesenchymal stromal cells was practically not detected in endothelial cells. Accumulation of the dye by macrophages depended on individual donor characteristics.
authors.affiliation: Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. olja_udartseva@rambler.ru.
authors.forename: O O
authors.initials: OO
authors.lastname: Udartseva
authors.forename: E R
authors.initials: ER
authors.lastname: Andreeva
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007211:Indoles / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism* / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000378:metabolism* / Q000494:pharmacology; D011524:Protoporphyrins / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011524:Protoporphyrins; C048577:aluminum tetrasulfophthalocyanine; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX