title: Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds.
abstract: In cerebral amyloid angiopathy patients, microbleeds often cluster, mostly occipital, and are associated with apolipoprotein E (APOE) genotype. Microbleeds also frequently occur in the asymptomatic, general population. In this population, we investigated spatial distribution of microbleeds and whether this is influenced by APOE genotype. In 292 persons with microbleeds, we labeled microbleeds on baseline and follow-up magnetic resonance images. We calculated distance between incident and prevalent microbleeds within and between persons and performed lobar segmentation on the magnetic resonance images. Subsequently, we investigated proximity and lobar distribution in strata of APOE genotype. Microbleeds occurred closer within persons than between persons (-42.2 mm, 95% confidence interval, -44.6 to -39.9; p < 0.001). Microbleeds within APOE ε2 and ε4 carriers occurred closer than those in persons with ε3ε3 genotype (-11.9 mm, 95% confidence interval, -24.4 to 0.6; p = 0.06). Persons with ε2 and ε4 alleles had a larger proportion of microbleeds in the occipital lobe than persons with ε3ε3 genotype. Similar to cerebral amyloid angiopathy patients, microbleeds in the general population cluster and the distribution is affected by APOE genotype.
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Institute for Health Sciences, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Loehrer
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. Electronic address: m.a.ikram@erasmusmc.nl.
authors.forename: M Arfan
authors.initials: MA
authors.lastname: Ikram
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Saloua
authors.initials: S
authors.lastname: Akoudad
authors.affiliation: Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Henri A
authors.initials: HA
authors.lastname: Vrooman
authors.affiliation: Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Aad
authors.initials: A
authors.lastname: van der Lugt
authors.affiliation: Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands.
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Meike W
authors.initials: MW
authors.lastname: Vernooij
mesh_terms: D000368:Aged; D000483:Alleles; D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D016657:Cerebral Amyloid Angiopathy / Q000235:genetics; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe; D015995:Prevalence; D012307:Risk Factors
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E
keywords: APOE; Cerebral microbleeds; Cerebrovascular disease; Epidemiology; Imaging marker; MRI; Population-based; Risk factor