title: Chemoprevention of prostate cancer by major dietary phytochemicals.
abstract: Prostate cancer continues to be one of the most commonly diagnosed diseases and the second leading cause of cancer-related deaths among men in the United States. Options exist to treat localized disease, including surgery, radiation therapy, and hormonal therapy, but clinical management of advanced prostate cancer is challenging. In the past few decades, chemoprevention involving naturally-occurring compounds has emerged as a promising and cost-effective approach to reduce incidence and morbidity of prostate cancer by inhibiting the precancerous events before the occurrence of clinical disease. The present review focuses on summarizing the recent advances in studies of major dietary phytochemicals and their role in prostate cancer development.
authors.affiliation: Assistant professor, Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, Pennsylvania 18766, U.S.A. ajay.bommareddy@wilkes.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Bommareddy
authors.forename: William
authors.initials: W
authors.lastname: Eggleston
authors.forename: Stacy
authors.initials: S
authors.lastname: Prelewicz
authors.forename: Andrea
authors.initials: A
authors.lastname: Antal
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Witczak
authors.forename: Dan F
authors.initials: DF
authors.lastname: McCune
authors.forename: Adam L
authors.initials: AL
authors.lastname: Vanwert
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology; D018890:Chemoprevention; D003474:Curcumin / Q000494:pharmacology; D006801:Humans; D000077276:Lycopene; D008297:Male; D064209:Phytochemicals / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D064209:Phytochemicals; D013267:Stilbenes; D002338:Carotenoids; D003474:Curcumin; D000077185:Resveratrol; D002211:Capsaicin; D000077276:Lycopene
keywords: Prostate cancer; capsaicin; curcumin; dietary phytochemicals; lycopene; resveratrol; review