title: Long-term exercise training for an individual with mixed corticobasal degeneration and progressive supranuclear palsy features: 10-year case report follow-up.
abstract: OBJECTIVE
  This case report describes the effects of long-term (10-year) participation in a community exercise program for a client with mixed features of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). The effects of exercise participation on both functional status and brain volume are described.
  
  
  METHODS
  A 60-year-old male dentist initially reported changes in gait and limb coordination. He received a diagnosis of atypical CBD at age 66 years; PSP was added at age 72 years. At age 70 years, the client began a therapist-led community group exercise program for people with Parkinson disease (PD). The program included trunk and lower extremity stretching and strengthening, upright balance and strengthening, and both forward and backward treadmill walking. The client participated twice weekly for 1 hour for 10 years and was reassessed in years 9 to 10.
  
  
  RESULTS
  Falls (self-reported weekly over the 10-year period of the study by the client and his wife) decreased from 1.9 falls per month in year 1 to 0.3 falls per month in year 10. Balance, walking endurance, and general mobility declined slightly. Gait speed (both comfortable and fast) declined; the client was unable to vary gait speed. Quantitative brain measurements indicated a slow rate of whole brain volume loss and ventricular expansion compared with clients with autopsy-proven CBD or PSP.
  
  
  CONCLUSIONS
  This client has participated consistently in a regular group exercise program for 10 years. He has reduced fall frequency, maintained balance and endurance, and retained community ambulation using a walker. Combined with the slow rate of brain volume loss, this evidence supports the efficacy of a regular exercise program to prolong longevity and maintain function in people with CBD or PSP.
authors.affiliation: T.M. Steffen, PT, PhD, School of Physical Therapy, Regis University, 3333 Regis Blvd, G-4, Denver, CO 80221-1099 (USA).
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Steffen
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Petersen
authors.forename: Leah
authors.initials: L
authors.lastname: Dvorak
authors.forename: Kejal
authors.initials: K
authors.lastname: Kantarci
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control; D000368:Aged; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D026741:Physical Therapy Modalities; D004856:Postural Balance / Q000502:physiology; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000503:physiopathology / Q000628:therapy*