title: Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas.
abstract: Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advanced cancer cells survive stressful conditions such as chemotherapy. Here we review our recent findings describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. These results propose a new and promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome.
authors.affiliation: Clinical Cooperation Unit Pediatric Oncology; German Cancer Research Center (DKFZ); Heidelberg, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Oehme
authors.forename: Marco
authors.initials: M
authors.lastname: Lodrini
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Brady
authors.forename: Olaf
authors.initials: O
authors.lastname: Witt
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001343:Autophagy / Q000187:drug effects* / Q000235:genetics; D004317:Doxorubicin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics; D004357:Drug Synergism; D056572:Histone Deacetylase Inhibitors / Q000008:administration & dosage*; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009447:Neuroblastoma / Q000188:drug therapy* / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D004317:Doxorubicin; C447828:HDAC10 protein, human; D006655:Histone Deacetylases
keywords: HDAC-inhibitor; HDAC10; drug resistance; lysosome; macroautophagy; neuroblastoma