title: Effects of prenatal exposure to antibodies against brain-specific anion transporter on cognitive functions in rats.
abstract: We studied the effects of single intravenous injection of antibodies to brain-specific transmembrane anion transporter (BSAT1; 5 mg/kg) to pregnant rats (gestation day 10) on cognitive functions and behavior of their progeny. One of major functions of BSAT1 (or Oatp1c1) is specific transport of thyroxin across the blood-brain barrier. Female rats of two control groups were injected with non-specific Ig and 0.9% NaCl. The progeny of rats receiving monoclonal antibodies to BSAT1 demonstrated memory impairment in the Y-maze, novel object recognition test, passive avoidance test, and Morris water maze test in comparison with the control group. Our findings suggest that single injection of monoclonal antibodies to BSAT1 during the prenatal period was followed by cognitive impairments, which were probably related to thyroxin deficiency in the nervous tissue.
authors.affiliation: Department of Fundamental and Applied Neurobiology, V. P. Serbskii State Research Center of Social and Forensic Psychiatry, Ministry of Health and Social Development of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health Care and Social Development, Moscow; P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. zubkov@ngs.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Zubkov
authors.forename: V P
authors.initials: VP
authors.lastname: Baklaushev
authors.forename: K Sh
authors.initials: KSh
authors.lastname: Kardashova
authors.forename: O I
authors.initials: OI
authors.lastname: Gurina
authors.forename: A Yu
authors.initials: AY
authors.lastname: Morozova
authors.forename: Z I
authors.initials: ZI
authors.lastname: Storozheva
authors.forename: Z I
authors.initials: ZI
authors.lastname: Kekelidze
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001362:Avoidance Learning; D003071:Cognition; D005260:Female; D018782:Maze Learning; D008570:Memory, Short-Term; D027701:Organic Cation Transport Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000523:psychology*; D051381:Rats
chemical_list: D000911:Antibodies, Monoclonal; D027701:Organic Cation Transport Proteins; C451262:Slco1c1 protein, rat