title: High-sensitivity brain SPECT system using cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator.
abstract: For high-sensitivity brain imaging, we have developed a two-head single-photon emission computed tomography (SPECT) system using a CdTe semiconductor detector and 4-pixel matched collimator (4-PMC). The term, '4-PMC' indicates that the collimator hole size is matched to a 2 × 2 array of detector pixels. By contrast, a 1-pixel matched collimator (1-PMC) is defined as a collimator whose hole size is matched to one detector pixel. The performance of the higher-sensitivity 4-PMC was experimentally compared with that of the 1-PMC. The sensitivities of the 1-PMC and 4-PMC were 70 cps/MBq/head and 220 cps/MBq/head, respectively. The SPECT system using the 4-PMC provides superior image resolution in cold and hot rods phantom with the same activity and scan time to that of the 1-PMC. In addition, with half the usual scan time the 4-PMC provides comparable image quality to that of the 1-PMC. Furthermore, (99m)Tc-ECD brain perfusion images of healthy volunteers obtained using the 4-PMC demonstrated acceptable image quality for clinical diagnosis. In conclusion, our CdTe SPECT system equipped with the higher-sensitivity 4-PMC can provide better spatial resolution than the 1-PMC either in half the imaging time with the same administered activity, or alternatively, in the same imaging time with half the activity.
authors.affiliation: Central Research Laboratory, Hitachi Ltd., Hitachi-shi, Ibaraki-ken, Japan.
authors.forename: Atsuro
authors.initials: A
authors.lastname: Suzuki
authors.forename: Wataru
authors.initials: W
authors.lastname: Takeuchi
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishitsu
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ueno
authors.forename: Keiji
authors.initials: K
authors.lastname: Kobashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kubo
authors.forename: Tohru
authors.initials: T
authors.lastname: Shiga
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D019187:Cadmium Compounds; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D019047:Phantoms, Imaging; D012666:Semiconductors; D012680:Sensitivity and Specificity; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*; D055815:Young Adult
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride