title: Robinson's landmark synthesis of tropinone.
abstract: The 1917 total synthesis of tropinone by Sir Robert Robinson represents a landmark achievement in organic synthesis. Decades ahead of its time in terms of its retrosynthetic logic and biomimetic approach, the elegant combination of these two elements in this synthesis continues to serve as an inspiration for the development of new and efficient strategies for complex molecule synthesis.
authors.affiliation: Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts, USA. movassag@mit.edu.
authors.forename: Jonathan William
authors.initials: JW
authors.lastname: Medley
authors.forename: Mohammad
authors.initials: M
authors.lastname: Movassaghi
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000266:history; D060326:Chemistry Techniques, Synthetic / Q000266:history*; D049672:History, 19th Century; D049673:History, 20th Century; D015394:Molecular Structure; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history*
chemical_list: D001688:Biological Products; D014326:Tropanes; C016808:3-tropinone