title: Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes.
abstract: Non-segmental vitiligo (NSV) is an enigmatic disease with various clinical courses. To empirically identify underlying subtypes of NSV, we performed latent class analysis (LCA) of 717 consecutive patients with NSV seen between 2006 and 2012 and were analyzed. Median age was 32 yrs (14-45), median age at NSV onset was 18 yrs (8-32), and median NSV duration 5 yrs (0.75-78.5). A two-class model showed the best fit. Of the 717 patients, 280 (39%) belonged to LC1 and 437 (61%) to LC2. LC1 patients had high probabilities for early disease onset (<12 yrs), halo nevi, family history of premature hair greying, Koebner phenomenon, previous episodes of repigmentation, and family history of vitiligo. By contrast, LC2 patients were characterized by a late disease onset (after or at the age of 12 yrs, median age of 30 yrs) and acrofacial localization without any lesions on trunk or limbs. These two LCA classes (LC1, 'prepubertal onset'; LC2, 'post-pubertal onset') may help refining results from genome-wide association studies (GWAS) and allow a more accurate genotype-phenotype correlation and help defining more directed treatment protocols.
authors.affiliation: Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin and University of Bordeaux and Inserm U1035, Bordeaux, France.
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.forename: Aurélie
authors.initials: A
authors.lastname: Le Thuaut
authors.forename: Thomas
authors.initials: T
authors.lastname: Jouary
authors.forename: Fabienne
authors.initials: F
authors.lastname: Ballanger
authors.forename: Alain
authors.initials: A
authors.lastname: Taieb
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bastuji-Garin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014820:Vitiligo / Q000145:classification* / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
keywords: endophenotype; latent class analysis; post-pubertal; prepubertal; vitiligo