title: Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression.
abstract: Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the hemopoiesis inducing microenvironment with decreased levels mesenchymal progenitor cells in the bone marrow are the mechanisms underlying the hemostimulating action of this substance.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. zgn@pharm.tsu.ru. G. N. Zyuz'kov.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E A
authors.initials: EA
authors.lastname: Losev
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.forename: A V
authors.initials: AV
authors.lastname: Krapivin
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanova
authors.forename: V E
authors.initials: VE
authors.lastname: Goldberg
authors.forename: D V
authors.initials: DV
authors.lastname: Reikchart
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000157:Aconitine / Q000494:pharmacology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D054697:Cytostatic Agents / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000378:metabolism; D008808:Mice, Inbred CBA; D023461:Myeloid Progenitor Cells / Q000187:drug effects / Q000502:physiology; D044968:Regenerative Medicine
chemical_list: D054697:Cytostatic Agents; C109326:napelline; D005472:Fluorouracil; D000157:Aconitine