title: Association of the A1298C polymorphism in MTHFR gene with ischemic stroke.
abstract: A meta-analysis was performed to assess the association between the methylenetetrahydrofolate reductase (MTHFR) A1298C genetic polymorphism and ischemic stroke. A comprehensive search was conducted to identify all case-control or cohort studies. The fixed or random effect pooled measure was selected based on the homogeneity between studies, as assessed by I(2). Meta-regression was used to explore the potential sources of between-study heterogeneity. Publication bias was estimated using Egger's linear regression test. Thirteen case-control studies corresponded to the inclusion criteria comprising 2133 patients and 2572 controls which were included in the present meta-analysis. After excluding articles that deviated from Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between MTHFR A1298C genetic polymorphism and risk of ischemic stroke were observed in dominant (odds ratio [OR] 1.227, 95% confidence interval [CI] 1.062-1.416) and codominant (OR 1.138, 95% CI 1.007-1.286) inheritance models. Moreover, in the subgroup analysis based on region (Asia and Europe), significant associations were observed in most genetic models in Asia but not in Europe. This meta-analysis suggests that MTHFR A1298C genetic polymorphism is associated with increased risk of ischemic stroke, and the C allele may be an important risk factor for ischemic stroke.
authors.affiliation: Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China.
authors.forename: Yili
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Public Health, Qingdao University Medical College, 38 Dengzhou Road, Qingdao 266021, China. Electronic address: zhangdf1961@126.com.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Ischemic stroke; MTHFR; Meta-analysis; Polymorphism; Risk factor