title: [Dynamics of serum visfatin level after abdominal surgery: a new proinflammatory marker in the early diagnosis?].
abstract: BACKGROUND
  Visfatin is a newly recognized adipocytokine produced mainly in visceral fat tissue. Beside its effect on insulin receptor, it serves as proinflammatory cytokine and its level can be changed during inflammatory processes. The aim of the study was to analyze dynamics of serum visfatine level in early period after abdominal surgery and compare it with other proinflammatory markers.
  
  
  RESULTS
  In prospective cross-sectional study 20 patients after elective laparotomic abdominal surgery (partial colectomy) were enrolled and dynamics of visfatin, leptin, resistin, adiponectin, TNF-α , IL-6 and CRP in period +12, +24, +48 and + 72 hours was monitored. Serum visfatin was elevated already in +24 hrs period after surgery comparing the culmination of serum level of TNF-α and IL-6 12-24 hrs later and CRP even 48-72 hrs later.
  
  
  CONCLUSIONS
  Serum visfatin was elevated very early after abdominal surgery and thus its dynamic may be an early predictor of inflammatory processes namely in patients with visceral obesity.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Teplan
authors.forename: Ladislav
authors.initials: L
authors.lastname: Šenolt
authors.forename: Hana
authors.initials: H
authors.lastname: Hulejová
authors.forename: Vladimír
authors.initials: V
authors.lastname: Teplan
authors.forename: Milena
authors.initials: M
authors.lastname: Štollová
authors.forename: Robert
authors.initials: R
authors.lastname: Gürlich
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003082:Colectomy; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D042241:Early Diagnosis; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D056128:Obesity, Abdominal / Q000097:blood*; D011184:Postoperative Period; D011446:Prospective Studies; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase
keywords: visfatin - abdominal surgery - proinflammatory cytokines - visceral obesity.