title: Cardiovascular risk factors in children after kidney transplantation--from short-term to long-term follow-up.
abstract: Cardiovascular-related mortality is 100-fold higher in pediatric renal transplant recipients than in the age-matched general population. Seventy-seven post-renal transplant children's charts were reviewed for cardiovascular risk factors at two and six months after transplantation (short term) and at two yr after transplantation and the last follow-up visit (mean 7.14 ± 3.5 yr) (long term). Significant reduction was seen in cardiovascular risk factors prevalence from two months after transplantation to last follow-up respectively: Hypertension from 52.1% to 14%, hypercholesterolemia from 48.7% to 33%, hypertriglyceridemia from 50% to 12.5%, anemia from 29.6% to 18.3%, hyperparathyroidism from 32% to 18.3% and hyperglycemia from 11.7% to 10%, and left ventricular hypertrophy from 25.8% at short term to 15%. There was an increase in the prevalence of obesity from 1.5% to 3.9% and of CKD 3-5 from 4.75% to 24%. The need for antihypertensive treatment decreased from 54% to 42%, and the percentage of patients controlled by one medication rose from 26% to 34%, whereas the percentage controlled by 2, 3, and 4 medications decreased from 21.9%, 5.5%, and 1.4% to 6%, 2%, and 0. Children after renal transplantation appear to have high rates of cardiovascular risk factors, mainly on short-term follow-up.
authors.affiliation: Pediatric Nephrology, Schneider Children Medical Center, Petach Tikva, Israel.
authors.forename: Maital
authors.initials: M
authors.lastname: Kaidar
authors.forename: Michael
authors.initials: M
authors.lastname: Berant
authors.forename: Irit
authors.initials: I
authors.lastname: Krauze
authors.forename: Roxana
authors.initials: R
authors.lastname: Cleper
authors.forename: Eitan
authors.initials: E
authors.lastname: Mor
authors.forename: Nathan
authors.initials: N
authors.lastname: Bar-Nathan
authors.forename: Miriam
authors.initials: M
authors.lastname: Davidovits
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000150:complications; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006943:Hyperglycemia / Q000150:complications; D006961:Hyperparathyroidism / Q000150:complications; D006973:Hypertension / Q000150:complications; D015228:Hypertriglyceridemia / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation; D008297:Male; D009765:Obesity / Q000150:complications; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents
keywords: cardiac function; kidney transplantation; pediatrics; renal transplantation