title: Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.
abstract: Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 single-nucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I.
authors.affiliation: State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Yang
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.forename: Lijie
authors.initials: L
authors.lastname: Guan
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Jiang
authors.forename: Guohui
authors.initials: G
authors.lastname: Lao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hao
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
mesh_terms: D000328:Adult; D044466:Asian People; D001714:Bipolar Disorder / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase