title: A combination trial of intradermal radiofrequency and hyaluronic acid filler for the treatment of nasolabial fold wrinkles: a pilot study.
abstract: BACKGROUND
  Within the last few years, hyaluronic acid (HA) fillers and radiofrequency (RF) devices have shown significant promise for skin rejuvenation. But the effects of HA only lasted for a relatively short duration. Therefore, we tried a new combination therapy of intradermal RF and HA filler.
  
  
  OBJECTIVE
  To evaluate the clinical efficacy of combination therapy of intradermal RF and HA filler for nasolabial fold (NLF) wrinkle reduction.
  
  
  METHODS
  Ten Korean female volunteers with mild to severe NLFs were enrolled. In the control group, five subjects were treated with HA filler alone. In the experimental group, the other five subjects were treated with intradermal RF prior to HA filler. Efficacy was evaluated based on the change on the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS) from baseline.
  
  
  RESULTS
  At 12 and 24 weeks after treatment, the experimental group showed significantly greater improvement in mean WSRS score compared to the control group. And two (40%) of the five patients in the experimental group achieved 'very much improved' and two (40%) showed 'much improved' at 12 weeks after treatment.
  
  
  CONCLUSIONS
  Intradermal RF treatment prior to HA filler injection may provide synergistic and long-lasting effects for the reduction of NLF wrinkles.
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine , Seoul , South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Yong Hee
authors.initials: YH
authors.lastname: Lee
authors.forename: Hyuk
authors.initials: H
authors.lastname: Kim
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Koh
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Park
authors.forename: Il-Hong
authors.initials: IH
authors.lastname: Bae
authors.forename: Kui Young
authors.initials: KY
authors.lastname: Park
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy / Q000009:adverse effects; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D060052:Nasolabial Fold; D010865:Pilot Projects; D011846:Radio Waves / Q000009:adverse effects; D000078702:Radiofrequency Therapy; D012060:Rejuvenation; D012720:Severity of Illness Index; D016037:Single-Blind Method; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D006820:Hyaluronic Acid