title: The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model.
abstract: Ciliary neurotrophic growth factor is considered a potential therapeutic agent for central nervous system diseases. We report first in vivo data of the ciliary neurotrophic growth factor peptide mimetic Cintrofin in a rat post-status epilepticus model. Cintrofin prevented long-term alterations in the number of doublecortin-positive neuronal progenitor cells and attenuated the persistence of basal dendrites. In contrast, Cintrofin did neither affect acute status epilepticus-associated alterations in hippocampal cell proliferation and neurogenesis nor reveal any relevant effect on seizure activity. Whereas status epilepticus caused a significant disturbance in spatial learning in reversed peptide-treated rats, the performance of Cintrofin-treated rats did not differ from controls. The study confirms that Cintrofin comprises an active sequence mimicking effects of its parent molecule. While the data argue against an antiepileptogenic effect, they indicate a putative disease-modifying impact of Cintrofin.
authors.affiliation: Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University Munich, Germany.
authors.forename: Vera
authors.initials: V
authors.lastname: Russmann
authors.forename: Natalie
authors.initials: N
authors.lastname: Seeger
authors.forename: Christina
authors.initials: C
authors.lastname: Zellinger
authors.forename: Martin
authors.initials: M
authors.lastname: Hadamitzky
authors.forename: Stanislava
authors.initials: S
authors.lastname: Pankratova
authors.forename: Hannes
authors.initials: H
authors.lastname: Wendt
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bock
authors.forename: Vladimir
authors.initials: V
authors.lastname: Berezin
authors.forename: Heidrun
authors.initials: H
authors.lastname: Potschka
mesh_terms: D000818:Animals; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology* / Q000627:therapeutic use; D000089662:Doublecortin Protein; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007858:Learning / Q000187:drug effects*; D017628:Microglia / Q000473:pathology; D018716:Molecular Mimicry; D009410:Nerve Degeneration / Q000188:drug therapy / Q000473:pathology; D055495:Neurogenesis; D009474:Neurons / Q000473:pathology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology
chemical_list: D020934:Ciliary Neurotrophic Factor; C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D010446:Peptide Fragments; C586181:cintrofin peptide
keywords: Ciliary neurotrophic factor; Epileptogenesis; Learning; Mimetic peptide; Neurogenesis; Status epilepticus