title: Artificial oxygen carriers based on perfluorodecalin-filled poly(n-butyl-cyanoacrylate) nanocapsules.
abstract: Poly(n-butyl-cyanoacrylate)-nanocapsules filled by perfluorodecalin (PFD) are proposed as potential oxygen carriers for blood substitute. The capsule dispersion is prepared via interfacial polymerisation from a PFD emulsion in water which in turn is generated by spontaneous phase separation. The resulting dispersion is capable of carrying approximately 10% of its own volume of gaseous oxygen, which is approximately half of the capacity of human blood. The volumes of the organic solvents and water are varied within a wide range, connected to a change of the capsule radius between 200 and 400 nm. The principal suitability of the capsule dispersion for intravenous application is proven in first physiological experiments. A total amount of 10 ml/kg body weight has been infused into rats, with the dispersion supernatant and a normal saline solution as controls. After the infusion of nanocapsules, the blood pressure as well as the heart rate remains constant on a normal level.
authors.affiliation: Institute for Physical Chemistry, CeNIDE, University of Duisburg-Essen , Essen , Germany .
authors.forename: Claudia
authors.initials: C
authors.lastname: Stephan
authors.forename: Carolin
authors.initials: C
authors.lastname: Schlawne
authors.forename: Stefan
authors.initials: S
authors.lastname: Grass
authors.forename: Indra N
authors.initials: IN
authors.lastname: Waack
authors.forename: Katja B
authors.initials: KB
authors.lastname: Ferenz
authors.forename: Michael
authors.initials: M
authors.lastname: Bachmann
authors.forename: Sabine
authors.initials: S
authors.lastname: Barnert
authors.forename: Rolf
authors.initials: R
authors.lastname: Schubert
authors.forename: Martin
authors.initials: M
authors.lastname: Bastmeyer
authors.forename: Herbert
authors.initials: H
authors.lastname: de Groot
authors.forename: Christian
authors.initials: C
authors.lastname: Mayer
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000494:pharmacology; D003487:Cyanoacrylates / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004659:Enbucrilate; D005466:Fluorocarbons / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008297:Male; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010100:Oxygen; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001802:Blood Substitutes; D003487:Cyanoacrylates; D005466:Fluorocarbons; D053769:Nanocapsules; C008805:perfluorodecalin; D004659:Enbucrilate; D010100:Oxygen