title: Engineered stealth porous silicon nanoparticles via surface encapsulation of bovine serum albumin for prolonging blood circulation in vivo.
abstract: Luminescent porous silicon nanoparticles (PSiNPs) have been widely used as drug delivery. However, fast biodegradation and short blood circulation have been major challenges for their biomedical applications. Herein, bovine serum albumin was readily encapsulated onto alkyl-terminated PSiNPs surfaces via hydrophobic interaction, which could significantly improve their water-dispersibility and long-term stability under physiological conditions. Furthermore, compared with PSiNPs alone, PSiNPs coated with bovine serum albumin remarkably reduced nonspecific cellular uptake in vitro and prolonged blood circulation in vivo.
authors.affiliation: Key Laboratory of Forest Genetics & Biotechnology (Ministry of Education of China), Advanced Analysis & Testing Center, Nanjing Forestry University , Nanjing 210037, P. R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
authors.forename: Wenyi
authors.initials: W
authors.lastname: Zhang
authors.forename: Jisen
authors.initials: J
authors.lastname: Shi
authors.forename: Shou-jun
authors.initials: SJ
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002417:Cattle; D006207:Half-Life; D006367:HeLa Cells; D006801:Humans; D055767:Immobilized Proteins / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology
chemical_list: D055767:Immobilized Proteins; D012710:Serum Albumin, Bovine; D012825:Silicon