title: Severe preeclampsia: are hemostatic and inflammatory parameters associated?
abstract: BACKGROUND
  Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE.
  
  
  METHODS
  D-Dimer, PAI-1, IL-8, IL-6, TNF-α, and IFN-γ concentrations were measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women.
  
  
  RESULTS
  D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and non-pregnant women. IL-8, IL-6, and IFN-γ also were higher in women with sPE compared to normotensive pregnant women. However, only IL-6 and IFN-γ were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-γ in sPE.
  
  
  CONCLUSIONS
  D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE.
authors.affiliation: Clinical and Toxicological Department, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; School of Medicine, Universidade Federal de São João Del Rei, Brazil.
authors.forename: Melina B
authors.initials: MB
authors.lastname: Pinheiro
authors.forename: Maria G
authors.initials: MG
authors.lastname: Carvalho
authors.forename: Olindo A
authors.initials: OA
authors.lastname: Martins-Filho
authors.forename: Letícia G
authors.initials: LG
authors.lastname: Freitas
authors.forename: Lara C
authors.initials: LC
authors.lastname: Godoi
authors.forename: Patrícia N
authors.initials: PN
authors.lastname: Alpoim
authors.forename: Karina B
authors.initials: KB
authors.lastname: Gomes
authors.forename: Luci M
authors.initials: LM
authors.lastname: Dusse
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology / Q000473:pathology; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D
keywords: D-Dimer; Inflammatory cytokines; PAI-1; Preeclampsia