title: Experimental substantiation of the efficiency of antioxidant therapy for post-traumatic arthritis.
abstract: Experimental post-traumatic arthritis was accompanied by overexpression of pro-inflammatory cytokines and imbalance in the collagen metabolism. Intraarticular injection of mexidol prevented free-radical degradation of collagen structures, contributed to activation of collagen synthesis and cartilage repair, and reduced the severity of inflammatory changes in the joint and the degree of secondary alteration of tissue structures.
authors.affiliation: Prof. N. I. Atyasov Department of General Surgery and Anesthesiology, N. P. Ogarev Mordovia State University, Saransk, Russia. piyanzina@mail.ru.
authors.forename: M I
authors.initials: MI
authors.lastname: Shutova
authors.forename: S A
authors.initials: SA
authors.lastname: Kozlov
authors.forename: A N
authors.initials: AN
authors.lastname: Zachvatov
authors.forename: S I
authors.initials: SI
authors.lastname: Kuznecov
authors.forename: I L
authors.initials: IL
authors.lastname: Anyushin
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D002356:Cartilage / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy*; D007270:Injections, Intra-Articular; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D007719:Knee Joint / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D010847:Picolines; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; C070020:emoxypine succinate; D003094:Collagen; D006909:Hydroxyproline