title: Solvent- and catalyst-free huisgen cycloaddition to rufinamide in flow with a greener, less expensive dipolarophile.
abstract: Give it a flow: A continuous-flow process for the synthesis of a 1,2,3-triazole precursor of Rufinamide has been developed. The protocol involves a solvent- and catalyst-free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes.
authors.affiliation: Department of Chemical Engineering and Chemistry, Micro Flow Chemistry and Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612AZ, Eindhoven (The Netherlands).
authors.forename: Svetlana
authors.initials: S
authors.lastname: Borukhova
authors.forename: Timothy
authors.initials: T
authors.lastname: Noël
authors.forename: Bert
authors.initials: B
authors.lastname: Metten
authors.forename: Eric
authors.initials: E
authors.lastname: de Vos
authors.forename: Volker
authors.initials: V
authors.lastname: Hessel
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D012997:Solvents; D014230:Triazoles / Q000737:chemistry*
chemical_list: D012997:Solvents; D014230:Triazoles; C079703:rufinamide
keywords: cycloaddition; green chemistry; microflow chemistry; novel process windows; solvent free