title: The complex interactions between radiation induced non-targeted effects and cancer.
abstract: Radiation induced non-targeted effects have been widely investigated in the last two decades for their potential impact on low dose radiation risk. In this paper we will give an overview of the most relevant aspects related to these effects, starting from the definition of the low dose scenarios. We will underline the role of radiation quality, both in terms of mechanisms of interaction with the biological matter and for the importance of charged particles as powerful tools for low dose effects investigation. We will focus on cell communication, representing a common feature of non-targeted effects, giving also an overview of cancer models that have explicitly considered such effects.
authors.affiliation: Istituto Superiore di Sanità (ISS), Rome, Italy; Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma1, Gruppo Collegato Sanità, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Campa
authors.affiliation: Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma1, Gruppo Collegato Sanità, Rome, Italy; Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Balduzzi
authors.affiliation: Istituto Superiore di Sanità (ISS), Rome, Italy; Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma1, Gruppo Collegato Sanità, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Dini
authors.affiliation: Istituto Superiore di Sanità (ISS), Rome, Italy; Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma1, Gruppo Collegato Sanità, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Esposito
authors.affiliation: Istituto Superiore di Sanità (ISS), Rome, Italy; Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma1, Gruppo Collegato Sanità, Rome, Italy. Electronic address: antonella.tabocchini@iss.it.
authors.forename: Maria Antonella
authors.initials: MA
authors.lastname: Tabocchini
mesh_terms: D024201:Bystander Effect / Q000528:radiation effects*; D002450:Cell Communication / Q000528:radiation effects*; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D016207:Cytokines / Q000096:biosynthesis; D017629:Gap Junctions / Q000378:metabolism; D042822:Genomic Instability / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011829:Radiation Dosage; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D016207:Cytokines; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
keywords: Cancer risk; Radiation induced non-targeted effects; Radiation quality