title: MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications.
abstract: The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and focuses on one of the most commonly used therapeutic radionuclides, (131)I. The purpose of this document is to provide guidance on the development of protocols for quantitative (131)I SPECT in radionuclide therapy applications that require regional (normal organs, lesions) and 3-dimensional dosimetry.
authors.affiliation: Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: Yuni K
authors.initials: YK
authors.lastname: Dewaraja
authors.forename: Michael
authors.initials: M
authors.lastname: Ljungberg
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Green
authors.forename: Pat B
authors.initials: PB
authors.lastname: Zanzonico
authors.forename: Eric C
authors.initials: EC
authors.lastname: Frey
authors.forename: Wesley E
authors.initials: WE
authors.lastname: Bolch
authors.forename: A Bertrand
authors.initials: AB
authors.lastname: Brill
authors.forename: Mark
authors.initials: M
authors.lastname: Dunphy
authors.forename: Darrell R
authors.initials: DR
authors.lastname: Fisher
authors.forename: Roger W
authors.initials: RW
authors.lastname: Howell
authors.forename: Ruby F
authors.initials: RF
authors.lastname: Meredith
authors.forename: George
authors.initials: G
authors.lastname: Sgouros
authors.forename: Barry W
authors.initials: BW
authors.lastname: Wessels
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002138:Calibration; D002986:Clinical Trials as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007457:Iodine Radioisotopes; D016499:Radioimmunotherapy; D011874:Radiometry; D011993:Recombinant Fusion Proteins / Q000493:pharmacokinetics / Q000627:therapeutic use; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D011993:Recombinant Fusion Proteins; C513931:SIP(L19) fusion protein; C119496:tositumomab I-131
keywords: 131I; MIRD; SPECT/CT, dosimetry; quantitative SPECT