title: Conjugates of a secoiridoid glucoside with a phenolic glucoside from the flower buds of Lonicera japonica Thunb.
abstract: Secoiridoid glucosides, including two conjugates with a phenolic and two conjugates with a nicotinic acid derivative (3 and 4), together with seven known secoiridoid derivatives, were isolated from flower buds of Lonicera japonica. The structures were elucidated by spectroscopic analyses. Anti-influenza activities of six isolated compounds were also evaluated by plaque assay and neuraminidase inhibitory assay.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan. Electronic address: kasiwada@tokushima-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: Yuka
authors.initials: Y
authors.lastname: Omichi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Kurimoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shibata
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Miyake
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Kirimoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D009980:Influenza A virus / Q000187:drug effects; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031239:Lonicera / Q000737:chemistry*; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009539:Nicotinic Acids / Q000737:chemistry / Q000302:isolation & purification*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D057888:Iridoid Glucosides; D009539:Nicotinic Acids; D010636:Phenols; D009439:Neuraminidase
keywords: Anti-influenza; Caprifoliaceae; Eugenol; Lonicera japonica; Nicotonic acid; Secoiridoid