title: Synthesis and characterization of a novel o-tolyltelluronic trimethyltin ester and its cytotoxic assessment in vitro.
abstract: A new arenetelluronic triorganotin ester, namely (Me3Sn)4[o-Me-PhTe(μ-O)(OH)O2)]2 (1) has been prepared by the reaction of o-tolyltelluronic acid and Me3SnCl in the presence of potassium hydroxide. The complex was fully characterized by elemental analysis, FT-IR, NMR ((1)H, (13)C, (119)Sn) spectroscopy and X-ray crystallography. Structure analysis revealed that the complex crystallized as Sn4Te2 units and a 1D linear chain was formed by intermolecular C-HO interactions. Cytotoxic assessments showed that the complex can induce apoptotic cell death via accumulation of ROS, collapse of the MMP and activating caspase-3. The results indicated that ROS is crucial to the cytotoxicity induced by the complex.
authors.affiliation: School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, P. R. China. macl856@163.com macl@lcu.edu.cn.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Ma
authors.forename: Shuang
authors.initials: S
authors.lastname: Cheng
authors.forename: Zhengsong
authors.initials: Z
authors.lastname: Hu
authors.forename: Qianli
authors.initials: Q
authors.lastname: Li
authors.forename: Rufen
authors.initials: R
authors.lastname: Zhang
authors.forename: Shaoliang
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008958:Models, Molecular; D008968:Molecular Conformation; D017382:Reactive Oxygen Species / Q000378:metabolism; D014001:Tin / Q000737:chemistry*; D014298:Trimethyltin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D017382:Reactive Oxygen Species; D014298:Trimethyltin Compounds; C046488:trimethyltin; D014001:Tin; D053148:Caspase 3; D020782:Matrix Metalloproteinases