title: Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease.
abstract: Rosiglitazone (ROG) has been shown to exert beneficial effects on glycemic control and renal protection. Circulatory fibroblast growth factor‑23 (FGF‑23) is a novel independent risk factor for chronic kidney disease (CKD) progression. The current study focused on how ROG impacts on injury of the kidney, and whether FGF‑23 is involved in the process. A total of 24 male Sprague Dawley rats, weighing 250‑280 g, were divided into four groups (n=6 per group): i) Normal; ii) ROG controls, treated with ROG (10 mg/kg/day); iii) CKD models, treated with adenine (200 mg/kg/day); and iv) ROG treatment, treated with ROG (10 mg/kg/day) and adenine (200 mg/kg/day). The rats were sacrificed after four weeks, and serum, urine and kidney tissues were collected. The data revealed that the serum levels of inorganic phosphate (Pi), intact parathyroid hormone (iPTH) and FGF‑23 were significantly higher in the CKD models compared with those in the normal group (P<0.01), while ROG significantly reduced the serum levels of Pi, iPTH and FGF‑23 (P<0.01). The ratio of protein/creatine (Cr) in the urine and the serum levels of Cr, blood urea nitrogen and uric acid were significantly increased in the CKD models compared with the normal group (P<0.01), however, ROG significantly reduced these parameters (P<0.05). Furthermore, ROG significantly alleviated the tubule interstitial damage index of the CKD models in comparison with that of the controls. These results indicated that ROG mitigates the lesions of chronic kidney disease induced by adenine, and that the system of Pi‑PTH‑FGF‑23 may contribute to this process. The possible mechanisms underlying this process require confirmation in future studies.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Sun Yat‑Sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lei
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Zheng
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.forename: Mingliang
authors.initials: M
authors.lastname: Hu
authors.forename: Rongjun
authors.initials: R
authors.lastname: Liu
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yu
mesh_terms: D000225:Adenine / Q000009:adverse effects*; D000818:Animals; D003404:Creatinine / Q000097:blood; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D000077154:Rosiglitazone; D013194:Staining and Labeling; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D003404:Creatinine; D000225:Adenine