title: IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg?
abstract: As IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations attempted to correlate the IL36RN genotype with GPP clinical presentations. These studies found that IL36RN mutations account for only a fraction of GPP cases presenting with concomitant psoriasis vulgaris (PV; common or typical psoriasis). Pathogenic alleles were also found in control populations, indicating that environmental triggers and/or modifier genes may contribute to the disease.
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK. Electronic address: Francesca.capon@kcl.ac.uk.
authors.forename: Francesca
authors.initials: F
authors.lastname: Capon
mesh_terms: D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology*
chemical_list: C122187:IL36RN protein, human; D007378:Interleukins