title: Effects of 5-year treatment with testosterone undecanoate on lower urinary tract symptoms in obese men with hypogonadism and metabolic syndrome.
abstract: OBJECTIVE
  To investigate the possible effects of testosterone undecanoate (TU) injections in a population of obese (mean age 57) hypogonadal men with lower urinary tract symptoms (LUTS) in a long-term observational study.
  
  
  METHODS
  Twenty obese hypogonadal men with metabolic syndrome were treated with TU injections every 12 weeks for 60 months; also 20 matched subjects in whom TU was unaccepted or contraindicated were used as controls. LUTS severity and the impact of TU injections were assessed by differences in International Prostate Symptom Score (IPSS), maximum urinary flow (Qmax) rate in milliliters, post-void residual (PVR) volume, and prostate size every 12 months in a 5-year controlled study.
  
  
  RESULTS
  TU injections did not produce differences in IPSS, Qmax, PVR, and prostate size in both groups. No modification in prostate-specific antigen (PSA) and hematocrit levels was also found between the 2 groups. Interestingly, controls showed increased incidence of prostatitis than TU-treated men (10% vs 30%, P <.01).
  
  
  CONCLUSIONS
  We showed that 5 years of TU treatment did not change IPSS, PVR, Qmax, or prostate size in obese hypogonadal men with metabolic syndrome and moderate LUTS at baseline. Therefore, long-term TU replacement therapy is a safe and effective treatment for reverting hypogonadal features related to metabolic syndrome and does not impact negatively on LUTS and prostate volume.
authors.affiliation: Experimental Medicine Department, Endocrinology and Food and Science Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Francomano
authors.affiliation: Experimental Medicine Department, Endocrinology and Food and Science Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ilacqua
authors.affiliation: Experimental Medicine Department, Endocrinology and Food and Science Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bruzziches
authors.affiliation: Experimental Medicine Department, Endocrinology and Food and Science Section, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lenzi
authors.affiliation: Experimental Medicine Department, Endocrinology and Food and Science Section, "Sapienza" University of Rome, Rome, Italy. Electronic address: antonio.aversa@uniroma1.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Aversa
mesh_terms: D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D059411:Lower Urinary Tract Symptoms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000728:Androgens; D013739:Testosterone; C010792:testosterone undecanoate