title: Neuroprotective effects of dipeptide analogue of brain-derived neurotrophic factor GSB-106 in in vitro experiments.
abstract: Dimeric dipeptide GSB-106, a novel structural analogue of neurotrophin BDNF, in doses from 10(-5) to 10(-8) M protected cultured immortalized mouse hippocampal HT-22 neurons from H2O2 or glutamate damage. The neuroprotective effect of GSB-106 was also shown on cultured SH-SY5Y human neuroblastoma cells after treatment with neurotoxin 6-hydroxidopamine. These data attest to functional similarity of GSB-106 and neurotrophin BDNF.
authors.affiliation: Laboratory for Pharmacology of Neuroprotection, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. logvinov_ilya@mail.ru.
authors.forename: I O
authors.initials: IO
authors.lastname: Logvinov
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: A V
authors.initials: AV
authors.lastname: Tarasiuk
authors.forename: P I
authors.initials: PI
authors.lastname: Antipov
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000633:toxicity; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016627:Oxidopamine / Q000633:toxicity; D013053:Spectrophotometry
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004151:Dipeptides; D018696:Neuroprotective Agents; D018698:Glutamic Acid; D016627:Oxidopamine; D006861:Hydrogen Peroxide