title: The effectiveness of borneol on pharmacokinetics changes of four ginsenosides in Shexiang Baoxin Pill in vivo.
abstract: Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine, widely used for cardiovascular diseases in the clinic. Ginsenosides are important effective components in SBP, but their pharmacokinetic characteristics are still not known. In this paper, we studied the pharmacokinetics of ginsenoside Rb1, Rc, Re and Rg1 in SBP and investigated the effect of borneol on the pharmacokinetic characteristic of ginsenosides based on an Agilent G6410A triple quadrupole LC/MS system. Results showed that the pharmacokinetic parameters of ginsenoside Rb1, Rc, Re and Rg1 in rat plasma after oral administration of SBP are significantly different with oral administration of SBP without Borneolum Syntheticum. Plasma pharmacokinetic profiles after oral administration of ginsenoside Rb1, Rc, Re, Rg1 and co-administration with borneol at three different ratios (10:1, 1:1 and 1:10 ginsenoside vs borneol, w/w) were also determined. It was demonstrated that borneol can elevate the plasma concentration of ginsenosides after co-admininstration.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; Shanghai Hutchison Pharmaceuticals Company, Shanghai, 200331, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Li
authors.initials: L
authors.lastname: Xiang
authors.forename: Shuping
authors.initials: S
authors.lastname: Wang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Jianfei
authors.initials: J
authors.lastname: Tao
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Chen
authors.forename: Changsen
authors.initials: C
authors.lastname: Zhan
authors.forename: Ximing
authors.initials: X
authors.lastname: Huang
authors.forename: Runhui
authors.initials: R
authors.lastname: Liu
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001892:Camphanes / Q000008:administration & dosage / Q000494:pharmacology*; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D036145:Ginsenosides / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics*; D041743:Herb-Drug Interactions; D016014:Linear Models; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001892:Camphanes; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C526712:shexiang baoxin; C022871:isoborneol
keywords: Shexiang Baoxin Pill; borneol; ginsenoside; pharmacokinetic; rat plasma