title: Mussel-inspired hyperbranched poly(amino ester) polymer as strong wet tissue adhesive.
abstract: Current medical adhesives based on cyanoacrylates typically exhibit cellular toxicity. In contrast, fibrin adhesives are non-toxic but have poor adhesive properties. To overcome these drawbacks we designed a simple and scalable adhesive precursor inspired by marine mussel adhesion that functioned with strong adhesion in wet conditions and with low cytotoxicity. Dopamine, an-amine derivative of an amino acid abundantly present in mussel adhesive proteins, was co-polymerised with a tri-functional vinyl monomer, to form a hyperbranched poly(β-amino ester) polymer termed poly(dopamine-co-acrylate) (PDA). A variety of molecular weights and crosslinking methods were analysed using an ex vivo porcine skin model and an almost 4 fold increase in wet adhesion strength was observed compared to TISSEEL(®) fibrin sealant. With a fast curing time, degradable properties and low cytotoxicity, PDA is highly attractive for medical purposes and could have a broad impact on surgeries where surgical tissue adhesives, sealants, and haemostatic agents are used.
authors.affiliation: Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Lígia P
authors.initials: LP
authors.lastname: Bré
authors.forename: Tianyu
authors.initials: T
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.forename: Ben
authors.initials: B
authors.lastname: Newland
authors.forename: Wenxin
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D002470:Cell Survival; D015718:Fibrin Tissue Adhesive / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013552:Swine; D014014:Tissue Adhesives / Q000737:chemistry*
chemical_list: D015718:Fibrin Tissue Adhesive; D011108:Polymers; D014014:Tissue Adhesives; C507253:poly(beta-amino ester)
keywords: Degradable; Dopamine derived; Low cytotoxicity; Natural catechol group; PAE; Wet polymeric adhesive