title: Estimation of the level of anxiety in rats: differences in results of open-field test, elevated plus-maze test, and Vogel's conflict test.
abstract: We compared individual anxiety assessed by three standard tests, open-field test, elevated plus-maze test, and Vogel conflict drinking test, in the same animals. No significant correlations between the main anxiety parameters were found in these three experimental models. Groups of animals with high and low anxiety rats were formed by a single parameter and subsequent selection of two extreme groups (10%). It was found that none of the tests could be used for reliable estimation of individual anxiety in rats. The individual anxiety level with high degree of confidence was determined in high-anxiety and low-anxiety rats demonstrating behavioral parameters above and below the mean values in all tests used. Therefore, several tests should be used for evaluation of the individual anxiety or sensitivity to emotional stress.
authors.affiliation: P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. s-sudakov@nphys.ru.
authors.forename: S K
authors.initials: SK
authors.lastname: Sudakov
authors.forename: G A
authors.initials: GA
authors.lastname: Nazarova
authors.forename: E V
authors.initials: EV
authors.lastname: Alekseeva
authors.forename: V G
authors.initials: VG
authors.lastname: Bashkatova
mesh_terms: D000818:Animals; D001007:Anxiety / Q000175:diagnosis* / Q000503:physiopathology; D003220:Conflict, Psychological; D003955:Diagnostic Tests, Routine / Q000379:methods*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior / Q000502:physiology; D013315:Stress, Psychological / Q000175:diagnosis* / Q000503:physiopathology