title: Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives.
abstract: The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Chen
authors.forename: Jiuxi
authors.initials: J
authors.lastname: Chen
authors.forename: Miaochang
authors.initials: M
authors.lastname: Liu
authors.forename: Jinchang
authors.initials: J
authors.lastname: Ding
authors.forename: Wenxia
authors.initials: W
authors.lastname: Gao
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Huang
authors.forename: Huayue
authors.initials: H
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011799:Quinazolines; D003300:Copper