title: Larvicidal activity of the active constituent isolated from Tabebuia avellanedae bark and structurally related derivatives against three mosquito species.
abstract: Mosquito larvicidal activities of active constituent isolated from Tabebuia avellanedae bark and its structurally related derivatives were examined against the fourth instar larvae of Aedes aegypti, Culex pipiens pallens, and Ochlerotatus togoi. The insecticidal constituent of T. avellanedae bark was isolated by chromatographic techniques and identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione. On the basis of the 50% lethal concentration (LC50) values against C. pipiens pallens larvae, the most toxic compound was 1,4-naphthalenedione (1.26 mg/L), followed by 1,2-naphthalenedione (1.43 mg/L), 1,4-naphthalenediol (3.20 mg/L), 2-chloro-3-pyrrolidino-1,4-naphthalenedione (5.11 mg/L), 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (8.30 mg/L), and 2-chloro-3-morpholino-1,4-naphthalenedione (12.98 mg/L). Similar results against A. aegypti and O. togoi larvae were observed for 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione and its derivatives. According to the LC50 values against three mosquito species, these compounds were less toxic than pirimiphos-methyl. Nonetheless, naturally occurring T. avaellenedae bark-derived materials could be useful as a natural mosquito control agent.
authors.affiliation: Department of Bioenvironmental Chemistry and Institute of Agricultural Science and Technology, Chonbuk National University , Jeonju 561-756, Republic of Korea.
authors.forename: Min-Gi
authors.initials: MG
authors.lastname: Kim
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000818:Animals; D009033:Culicidae / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D009032:Mosquito Control; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D007306:Insecticides; D010936:Plant Extracts