title: Hypoxia signaling--license to metastasize.
abstract: Hypoxia-inducible factors (HIF) have long been linked to malignant tumor phenotypes in various cancer types, and several downstream mediators of HIF action are deregulated in metastatic carcinomas. A new study links hypoxia-induced collagen remodeling to sarcoma progression, providing evidence for unifying mechanisms of carcinoma and sarcoma metastasis.
authors.affiliation: 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York; and 2Howard Hughes Medical Institute, Chevy Chase, Maryland.
authors.forename: Sakari
authors.initials: S
authors.lastname: Vanharanta
authors.forename: Joan
authors.initials: J
authors.lastname: Massagué
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008914:Minoxidil / Q000494:pharmacology*; D009362:Neoplasm Metastasis; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D012509:Sarcoma / Q000473:pathology* / Q000556:secondary*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008914:Minoxidil; D003094:Collagen; D008240:Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase