title: Heredity of restless legs syndrome in a pregnant population.
abstract: OBJECTIVE
  To synthesize published research on genetic and heredity findings related to restless legs syndrome (RLS) in a pregnant population.
  
  
  METHODS
  PubMed, CINAHL, and PsycINFO databases and reference lists from published articles.
  
  
  METHODS
  Literature searches were conducted for primary research studies published in English on the genetic and heredity findings of RLS in pregnant populations.
  
  
  METHODS
  Study characteristics and findings related to genetic and heredity aspects of RLS in a pregnant population.
  
  
  RESULTS
  Five data-based articles met the criteria for study inclusion. Study findings comprised Level-2 and Level-3 evidence. Four of the five studies were larger population studies and contained a subset of pregnant participants. Parity and family history were important predictors of RLS proband status. Probands reported symptoms were often initiated during or after pregnancy.
  
  
  CONCLUSIONS
  Symptoms of RLS for female probands are often initiated during pregnancy or after childbirth. A history of RLS in a previous pregnancy and family history of RLS were strong predictors of RLS in the current pregnancy. Future research on genetic associations of RLS in pregnancy is warranted.
authors.forename: Mary Dawn
authors.initials: MD
authors.lastname: Hennessy
authors.forename: Frances Aimee
authors.initials: FA
authors.lastname: De La Torre
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005820:Genetic Testing / Q000379:methods; D040941:Heredity / Q000235:genetics*; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011256:Pregnancy Outcome; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000453:epidemiology* / Q000235:genetics*; D018570:Risk Assessment
keywords: family history; gender; genetics; heredity; pregnancy; restless legs syndrome