title: Cancer chemopreventive diterpenes from Salvia corrugata.
abstract: NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity.
authors.affiliation: Department of Pharmacy, University of Genoa, via Brigata Salerno 13, 16147 Genoa, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Giacomelli
authors.forename: Samuel
authors.initials: S
authors.lastname: Bertrand
authors.forename: Andreas
authors.initials: A
authors.lastname: Nievergelt
authors.forename: Vincent
authors.initials: V
authors.lastname: Zwick
authors.forename: Claudia
authors.initials: C
authors.lastname: Simoes-Pires
authors.forename: Laurence
authors.initials: L
authors.lastname: Marcourt
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Rivara-Minten
authors.forename: Muriel
authors.initials: M
authors.lastname: Cuendet
authors.forename: Angela
authors.initials: A
authors.lastname: Bisio
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Wolfender
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007558:Italy; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*
chemical_list: D045784:Abietanes; D056572:Histone Deacetylase Inhibitors; C103399:royleanone; D016660:NAD(P)H Dehydrogenase (Quinone)
keywords: Abietane; Diterpenes; Fruticulin C; Histone deacetylase; Icetexane; Quinone reductase; Salvia corrugata