title: Regression analysis of multivariate current status data with dependent censoring: application to ankylosing spondylitis data.
abstract: Multivariate current-status failure time data consist of several possibly related event times of interest, in which the status of each event is determined at a single examination time. If the examination time is intrinsically related to the event times, the examination is referred to as dependent censoring and needs to be taken into account. Such data often occur in clinical studies and animal carcinogenicity experiments. To accommodate for possible dependent censoring, this paper proposes a joint frailty model for event times and dependent censoring time. We develop a likelihood approach using Gaussian quadrature techniques for obtaining maximum likelihood estimates. We conduct extensive simulation studies for investigating finite-sample properties of the proposed method. We illustrate the proposed method with an analysis of patients with ankylosing spondylitis, where the examination time may be dependent on the event times of interest.
authors.affiliation: Department of Statistics and Informatics Science, Providence University, Taichung 43301, Taiwan; Department of Financial and Computational Mathematics, Providence University, Taichung, Taiwan.
authors.forename: Chyong-Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: James Cheng-Chung
authors.initials: JC
authors.lastname: Wei
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Hsu
authors.forename: Ming-Yung
authors.initials: MY
authors.lastname: Lee
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D016013:Likelihood Functions; D015233:Models, Statistical; D012044:Regression Analysis; D013167:Spondylitis, Ankylosing / Q000503:physiopathology
chemical_list: D007070:Immunoglobulin A
keywords: Gaussian quadrature techniques; dependent censoring; frailty model; multivariate current-status data