title: Association of FcγRIIIa-158V/F with systemic lupus erythematosus in a Chinese population.
abstract: OBJECTIVE
  It has long been a controversy that polymorphisms in FcγRIIIa (CD16A) receptors are associated with systemic lupus erythematosus (SLE). We aimed to verify the association of FcγRIIIa polymorphisms with SLE in a large Chinese population.
  
  
  METHODS
  We genotyped FcγRIIIa-158V/F (rs396991) using a pyro-sequencing assay (PSQ 96MA) in a total of 732 individuals with SLE (390 lupus nephritis and 342 non-lupus nephritis) and 886 controls. Meta-analysis was used to examine the association of the FcγRIIIa-F158 allele with SLE and lupus nephritis with RevMan 5.
  
  
  RESULTS
  The allele frequencies of FcγRIIIa-F158 were significantly increased in SLE (OR 1.293, 95%CI 1.111-1.505, P = 0.0009). There was significant skewing in the distribution of FcγRIIIa genotypes between SLE patients and controls (P = 0.0026 for 158 F/F vs. 158F/V and 158V/V, OR 1.604, 95%CI 1.089-2.361). Serositis was more common in patients with the FcγRIIIa-F158 allele and FcγRIIIa-F/F genotype, and low complement was more common in patients with the FcγRIIIa-F/F genotype. There was no skewing in the distribution of FcγRIIIa genotypes in the lupus nephritis group. No association was found for the frequencies of the FcγRIIIa-F158 allele and 158F/F genotype compared with the V158 allele and F/V plus V/V genotypes, respectively, between lupus nephritis and SLE without nephritis patients in a meta-analysis of 11 Asian studies.
  
  
  CONCLUSIONS
  Our results suggest that the low-binding allele FcγRIIIa-158F is one of the risk factors for SLE in the Chinese population.
authors.affiliation: Department of Rheumatology, Renji Hospital, Shanghai Institute of Rheumatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Qian
authors.forename: Xinfang
authors.initials: X
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D008181:Lupus Nephritis / Q000208:ethnology / Q000235:genetics / Q000276:immunology; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: C496124:FCGR3A protein, human; D017452:Receptors, IgG
keywords: Chinese; Fcγ receptor; lupus nephritis; systemic lupus erythematosus