title: Role of the PTEN signaling pathway in autism spectrum disorder.
abstract: Autism is an etiologically heterogeneous group of neurodevelopmental disorders, diagnosed mostly by the clinical behavioral phenotypes. The concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last decade. In this review, we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry, as well as genetic mouse models with Pten manipulations. Particularly, accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Lv
authors.forename: Tian-Lin
authors.initials: TL
authors.lastname: Cheng
authors.forename: Zi-Long
authors.initials: ZL
authors.lastname: Qiu
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human