title: [Effects of metabolic syndrome on multi-vessel lesions of symptomatic intracranial atherosclerosis].
abstract: OBJECTIVE
  To explore the effects of metabolic syndrome (MS) on multi-vessel lesions of symptomatic intracranial atherosclerosis.
  
  
  METHODS
  During April 2009 and October 2010, a total of 139 consecutive hospitalized patients with symptomatic intracranial atherosclerosis were recruited to undergo magnetic resonance angiography (MRA) or/and CT angiography (CTA) or/and digital subtraction angiography (DSA) to measure the stenotic degree and numbers of intracranial atherosclerosis. They were divided into 2 groups according to lesion numbers: single and multi-vessel lesions. MS was defined by the criteria of the Adult Treatment Panel III to examine the incidences of MS. The risk factors were analyzed for multi-vessel lesions of symptomatic intracranial atherosclerosis to explore the relationship between MS and multi-vessel lesions.
  
  
  RESULTS
  Among them, 210 intracranial atherosclerotic lesions were documented. Fifty-nine (42.4%) patients had two or more lesions (group with multi-vessel lesions). The incidence of MS was 70.5%. The rates of MS in groups of single and multi-vessel lesions were 56.3% and 89.8% respectively. And statistical significance existed between two groups (P < 0.001). Moreover, the number of MS components increased gradually with the number of lesions (P < 0.001). For the analysis of individual criteria for MS, only abnormal glycemia was found to be associated with multi-vessel lesions (P = 0.002). And multiple Logistic regression analysis showed that MS was associated with multi-vessel lesions of intracranial atherosclerosis (P = 0.001).
  
  
  CONCLUSIONS
  MS is an independent predictor for multi-vessel lesions of intracranial atherosclerosis. And its intervention may be an important preventive strategy for intracranial multi-vessel atherosclerosis.
authors.affiliation: Department of Neurology, Third Affiliated Hospital, Anhui Medical University, Hefei 230061, China.
authors.forename: Shuang-gen
authors.initials: SG
authors.lastname: Zhu
authors.forename: You-ling
authors.initials: YL
authors.lastname: Zhu
authors.forename: Zhi-fei
authors.initials: ZF
authors.lastname: Huang
authors.forename: Deng-yue
authors.initials: DY
authors.lastname: Zhai
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhou
authors.forename: Yan-fang
authors.initials: YF
authors.lastname: Mu
authors.forename: De-zhi
authors.initials: DZ
authors.lastname: Liu
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Liu
authors.forename: Ge-Lin
authors.initials: GL
authors.lastname: Xu
authors.forename: Xin-feng
authors.initials: XF
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D018810:Magnetic Resonance Angiography; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D055815:Young Adult