title: Palladium-catalyzed synthesis of 3-acylated indoles involving oxidative cross-coupling of indoles with α-amino carbonyl compounds.
abstract: A new and selective C-N bond oxidative cleavage method to 3-acylated indoles by Pd-catalyzed oxidative cross coupling of indoles with α-amino carbonyl compounds has been developed; moreover, one-pot synthesis of 3-acylated indoles from 2-ethynylanilines and α-amino carbonyl compounds has also been established. Importantly, the products 3-acylated indoles can be used to construct polyheterocyclic compound, which can be employed as efficient probes for Hg(2+) and Fe(3+).
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Xiao-Kang
authors.initials: XK
authors.lastname: Guo
authors.forename: Jian-Nan
authors.initials: JN
authors.lastname: Xiang
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000215:Acylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D007211:Indoles; D007659:Ketones; D009942:Organometallic Compounds; D010165:Palladium