title: [Expression and clinical significance of vascular endothelial growth factor-C and nm23-H1 in stage II and III colorectal carcinomas].
abstract: OBJECTIVE
  To discuss the expression and clinical significance of VEGF-C and nm23-H1 in stage II and III colorectal carcinomas.
  
  
  METHODS
  SP immunohistochemical staining was employed to determine the expression of vascular endothelial growth factor-C (VEGF-C) and nm23-H1 in the tumor tissues of 110 cases of stage II and III colorectal carcinomas and in the adjacent mucosal tissues of 53 cases as control, and analyze their correlation with cliniopathological features and prognosis.
  
  
  RESULTS
  The positive expression of VEGF-C in the carcinoma tissues was 71.8%, significantly higher than that in the adjacent mucosal tissues (22.6%, P < 0.001). The positive expression of nm23-H1 in the carcinoma tissues was 57.3%, significantly lower than that in the adjacent mucosal tissues (90.6%, P < 0.001). The expression of VEGF-C was significantly correlated with lymph node metastasis (P < 0.05), and the nm23-H1 expression was significantly correlated with lymph node metastasis and pathological type (P < 0.05). The expression of VEGF-C and nm23-H1 did not show a significant correlation with age, gender, primary tumor site, tumor size and depth of invasion (P > 0.05). The VEGF-C expression was negatively related with nm23-H1 expression in colorectal carcinoma (r = -0.361, P < 0.001). The median overall survival (MOS) and median disease free survival (MDFS) of 110 patients with colorectal carcinoma were 55 and 48 months, respectively. The colorectal patients with different VEGF-C and nm23-H1 expression showed significant differences in the 5-year OS rate and 5-year DFS rate (P < 0.001). The patients with negative VEGF-C expression and positive nm23-H1 expression had a better prognosis.
  
  
  CONCLUSIONS
  The joint detection of VEGF-C and nm23-H1 expression is very promising in prediction of the prognosis of patients with stage II and III colorectal carcinoma. However, whether it can be used as a marker in prognosis judgment needs further investigation.
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Qian-qian
authors.initials: QQ
authors.lastname: Geng
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Tang
authors.forename: En-xiao
authors.initials: EX
authors.lastname: Li
authors.forename: Yin-ying
authors.initials: YY
authors.lastname: Wu
authors.forename: Guan-jun
authors.initials: GJ
authors.lastname: Zhang
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism*; D011379:Prognosis; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; D042582:Vascular Endothelial Growth Factor C