title: Treatment outcomes of a combined cognitive behavior therapy and pharmacotherapy for a sample of women with and without substance abuse histories on an acute psychiatric unit: do therapeutic alliance and motivation matter?
abstract: OBJECTIVE
  Women with comorbid psychiatric and substance abuse problems (PwSA) experience more consequences from their use and typically have the poorest prognosis and outcome, compared to those with psychiatric problems but without substance abuse problems (PwoSA). The present study examined outcomes of a combined intensive inpatient cognitive behavior therapy (CBT) and pharmacotherapy program for women with PwSA and PwoSA.
  
  
  METHODS
  Sample consisted of 117 women on a women-only acute inpatient unit (PwSA = 50, PwoSA = 67).
  
  
  RESULTS
  Women in both groups made significant improvements in psychological functioning. High motivation at admission and therapeutic alliance at discharge were associated with improved psychological functioning at discharge for both groups.
  
  
  CONCLUSIONS
  Findings provide preliminary support for the efficacy of a combined CBT and pharmacotherapy program for women with psychiatric diagnoses on a women-only acute inpatient unit, and for pre-treatment motivation and therapeutic alliance as important correlates of better treatment outcomes.
authors.affiliation: Rutgers, The State University of New Jersey, Piscataway, New Jersey.
authors.forename: Nickeisha
authors.initials: N
authors.lastname: Clarke
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Mun
authors.forename: Shalonda
authors.initials: S
authors.lastname: Kelly
authors.forename: Helene R
authors.initials: HR
authors.lastname: White
authors.forename: Katherine
authors.initials: K
authors.lastname: Lynch
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000523:psychology / Q000628:therapy; D001714:Bipolar Disorder / Q000523:psychology / Q000628:therapy; D016022:Case-Control Studies; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy; D017831:Diagnosis, Dual (Psychiatry); D001068:Feeding and Eating Disorders / Q000523:psychology / Q000628:therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D001523:Mental Disorders / Q000523:psychology / Q000628:therapy*; D008875:Middle Aged; D009042:Motivation; D015999:Multivariate Analysis; D010817:Physician-Patient Relations; D013811:Psychotherapeutic Processes; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D012044:Regression Analysis; D012559:Schizophrenia / Q000150:complications / Q000628:therapy; D019966:Substance-Related Disorders / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs