title: [Malignant hyperthermia: multifactorial events leading to a crisis].
abstract: This case-report focused on the occurrence of a crisis of malignant hyperthermia on a young biker (21 y.o.) victim of a severe traffic accident. This observation gives some key points: the delayed occurrence of the crisis after 4 hours of surgery, the multi-factorial events that triggered the crisis; the choice to perform a quick diagnosis through gene analysis in comparison to the standard tests of caffeine on a muscular biopsy. These different points are discussed with a proposal of algorithm in the situation.
authors.affiliation: Département d'anesthesie, hôpital Foch, 40, rue Worth, BP 36, 92151 Suresnes cedex, France. Electronic address: m.leguen@hopital-foch.org.
authors.forename: M
authors.initials: M
authors.lastname: Le Guen
authors.forename: H
authors.initials: H
authors.lastname: Houissa
authors.forename: O
authors.initials: O
authors.lastname: Langeron
mesh_terms: D000063:Accidents, Traffic; D000465:Algorithms; D001642:Bicycling / Q000293:injuries; D001706:Biopsy; D002110:Caffeine; D000697:Central Nervous System Stimulants; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000188:drug therapy* / Q000628:therapy; D009104:Multiple Trauma / Q000628:therapy; D012121:Respiration, Artificial; D012206:Rhabdomyolysis / Q000209:etiology / Q000628:therapy; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine
keywords: Diagnostic génétique; Genetic diagnosis; Hyperthermie maligne; Malignant hyperthermia; Polytrauma; Polytraumatisme