title: Fabrication of water-dispersible and biocompatible red fluorescent organic nanoparticles via PEGylation of aggregate induced emission enhancement dye and their cell imaging applications.
abstract: PEGylated red fluorescent organic nanoparticles (FONs) with aggregate induced emission enhancement (AIEE) properties have been prepared via self assembly of a cyano-substituted diarylethene derivate dye (C18-R) and synthetic copolymers, which were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization using stearyl methacrylate and poly(ethylene glycol) methacrylate as monomers. Thus obtained FONs were characterized by a series of techniques including transmission electron microscopy, Fourier transform infrared spectroscopy and fluorescent spectroscopy. To explore their potential biomedical applications, biocompatibility and cell uptake behavior of these red FONs were subsequently investigated. We demonstrated that FONs showed uniform morphology, suitable particle size (70-90 nm), high water dispersibility, strong red fluorescence and excellent biocompatibility, making them promising for bioimaging applications.
authors.affiliation: Department of Chemistry/Institute of Polymers, Nanchang University, Nanchang 330031, China; Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), China. Electronic address: xiaoyongzhang1980@gmail.com.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), China.
authors.forename: Xiqi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Chemistry/Institute of Polymers, Nanchang University, Nanchang 330031, China.
authors.forename: Wanyun
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Chemistry/Institute of Polymers, Nanchang University, Nanchang 330031, China.
authors.forename: Yiwang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), China. Electronic address: weiyen@tsinghua.edu.cn.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
mesh_terms: D008689:Methacrylates / Q000737:chemistry; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D008689:Methacrylates; C524499:polyethylene glycol methacrylate; D014867:Water; D011092:Polyethylene Glycols
keywords: Aggregation induced emission; Biocompatibility; Cell imaging; Cyano-substituted diarylethene derivate dye; Fluorescent organic nanoparticles; PEGylation