title: Role of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosis and management of pancreatic cancer; comparison with multidetector row computed tomography, magnetic resonance imaging and endoscopic ultrasonography.
abstract: OBJECTIVE
  We aimed to analyze the contribution of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging to the diagnosis and management of pancreatic cancer compared with multidetector row computed tomography (MDCT), magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS).
  
  
  METHODS
  We retrospectively scanned the data of 52 patients who were referred for FDG PET/CT imaging for evaluation of pancreatic lesions greater than 10mm. The diagnostic performances of 4 imaging methods and the impact of PET/CT on the management of pancreatic cancer were defined.
  
  
  RESULTS
  Pancreatic adenocarcinoma was diagnosed in 33 of 52 patients (63%), 15 patients had benign diseases of pancreas (29%), and 4 patients were normal (8%). Sensitivity and NPV of EUS and PET/CT were equal (100%) and higher than MDCT and MRI. Specificity, PPV and NPV of PET/CT were significantly higher than MDCT. However, sensitivities of two imaging methods were not significantly different. There was no significant difference between PET/CT and MRI and EUS for these values. When the cut-off value of SUVmax was 3.2, the most effective sensitivity and specificity values were obtained. PET/CT contributed to the management of pancreatic cancer in 30% of patients.
  
  
  CONCLUSIONS
  FDG PET/CT is a valuable imaging method for the diagnosis and management of pancreatic cancer, especially when applied along with EUS as first line diagnostic tools.
authors.affiliation: Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey. Electronic address: ngozubuyukoglu@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Ergul
authors.affiliation: Clinic of Nuclear Medicine, Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Gundogan
authors.affiliation: Department of Gastroenterology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tozlu
authors.affiliation: Department of Radiology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Toprak
authors.affiliation: Department of Surgery, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kadıoglu
authors.affiliation: Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Aydin
authors.affiliation: Clinic of Nuclear Medicine, Istanbul Research and Training Hospital, Istanbul, Turkey.
authors.forename: T F
authors.initials: TF
authors.lastname: Cermik
mesh_terms: D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D064847:Multimodal Imaging; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography; Cáncer de páncreas; Diagnosis; Diagnóstico; Estadificación; Pancreatic cancer; Papel de (18)F-Fluorodeoxiglucosa por emisión de positrones/tomografía computarizada; Staging