title: Relationship between cerebrospinal fluid flow, ventricles morphology, and DTI properties in internal capsules: differences between Alzheimer's disease and normal-pressure hydrocephalus.
abstract: BACKGROUND
  Normal-pressure hydrocephalus (NPH) and Alzheimer's disease (AD) have some similar clinical features and both involve white matter and cerebrospinal fluid (CSF) disorders.
  
  
  OBJECTIVE
  To compare putative relationships between ventricular morphology, CSF flow, and white matter diffusion in AD and NPH.
  
  
  METHODS
  Thirty patients (18 with AD and 12 with suspected NPH) were included in the study. All patients underwent a 3-Tesla MRI scan, which included phase-contrast MRI of the aqueduct (to assess the aqueductal CSF stroke volume) and a DTI session (to calculate the fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) in the internal capsules).
  
  
  RESULTS
  FA was correlated with ventricular volume in the suspected NPH population (P < 0.001; rs = 0.88), whereas the ADC was highly correlated with the aqueductal CSF stroke volume in AD (P < 0.001; rs = 0.79).
  
  
  CONCLUSIONS
  Although AD and NPH both involve CSF disorders, the two diseases do not have the same impact on the internal capsules. The magnitude of the ADC is related to the aqueductal CSF stroke volume in AD, whereas FA is related to ventricular volume in NPH.
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France daouk.joel@chu-amiens.fr.
authors.forename: Joël
authors.initials: J
authors.lastname: Daouk
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Medical Image Processing Unit, Amiens University Hospital, France.
authors.forename: Bader
authors.initials: B
authors.lastname: Chaarani
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Geriatric Department, Amiens University Hospital, France.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Zmudka
authors.affiliation: Neurosurgery Department, Amiens Univwsersity Hospital, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Capel
authors.affiliation: Neurosurgery Department, Amiens Univwsersity Hospital, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Fichten
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Medical Image Processing Unit, Amiens University Hospital, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Bouzerar
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Radiology Department, Amiens University Hospital, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gondry-Jouet
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Geriatric Department, Amiens University Hospital, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Jouanny
authors.affiliation: Bioflow Image Laboratory, University of Picardie Jules Verne, France Medical Image Processing Unit, Amiens University Hospital, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Balédent
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D016880:Anisotropy; D002552:Cerebral Ventricles / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011446:Prospective Studies
keywords: Alzheimer's disease; cerebrospinal fluid flow; diffusion tensor imaging; normal-pressure hydrocephalus