title: Hypertrophic olivary degeneration with gadolinium enhancement after posterior fossa surgery in a child with medulloblastoma.
abstract: Hypertrophic olivary degeneration (HOD) is a rare transsynaptic form of degeneration occurring secondary to the disruption of the dentato-rubro-olivary pathway ("Guillain-Mollaret triangle"). HOD can be caused by ischemic, hemorrhagic, traumatic, or neoplastic lesions, and it can also occur following posterior fossa surgery. MRI characteristics of HOD include T2 signal increase and hypertrophy. To date, blood–brain barrier disruption has not been reported in HOD. Here, we present the first case of HOD with temporary gadolinium enhancement in a 10-year-old child 7 months after resection of a posterior fossa medulloblastoma. The recognition of gadolinium enhancement as a radiological feature of HOD may help to distinguish between this benign secondary condition and tumor recurrence.
authors.forename: Johannes
authors.initials: J
authors.lastname: Nowak
authors.forename: Balint
authors.initials: B
authors.lastname: Alkonyi
authors.forename: Stefan
authors.initials: S
authors.lastname: Rutkowski
authors.forename: György A
authors.initials: GA
authors.lastname: Homola
authors.forename: Monika
authors.initials: M
authors.lastname: Warmuth-Metz
mesh_terms: D002528:Cerebellar Neoplasms / Q000601:surgery*; D002648:Child; D003388:Cranial Fossa, Posterior / Q000601:surgery*; D005260:Female; D005682:Gadolinium; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008527:Medulloblastoma / Q000601:surgery*; D009410:Nerve Degeneration / Q000209:etiology*; D009847:Olivary Nucleus / Q000473:pathology*; D011183:Postoperative Complications / Q000503:physiopathology*
chemical_list: D005682:Gadolinium