title: To press or not to press, and if so, with what? A single question-focused meta-analysis of vasopressor choice during regional anesthesia in obstetrics.
abstract: Given the underlying assumption that reasonable maternal hemodynamics can be achieved with either ephedrine or phenylephrine, this focused meta-analysis addresses the impact of vasopressor choice on resultant neonatal Apgar scores during regional anesthesia. The literature was systematically searched for randomized trials of obstetric vasopressor use employing standard search tools. Only the highest quality trials were included. Of 142 studies retrieved, 9 met the defined inclusion criteria. Apgar scores at 1 and 5 minutes in the ephedrine group (served as control) vs the phenylephrine group did not differ at either time epoch; no abnormal values prevailed in either group (relative risk, 0.88; CI, 0.79-1.16). This meta-analysis focused on the most clinically relevant, immediately available information pertinent in the obstetric suite, the Apgar score, and found that ephedrine and phenylephrine did not differ in their effect on this metric. The current meta-analysis provides an updated, evidence-based validation of vasopressor use from the American Society of Anesthesiologists' 2007 "Practice Guidelines for Obstetric Anesthesia".
authors.affiliation: Virginia Commonwealth University Medical Center, Richmond, Virginia, USA. cbiddle@hsc.vcu.edu
authors.forename: Chuck
authors.initials: C
authors.lastname: Biddle
mesh_terms: D000773:Anesthesia, Obstetrical / Q000379:methods*; D001034:Apgar Score; D004809:Ephedrine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000517:prevention & control; D007231:Infant, Newborn; D010656:Phenylephrine / Q000494:pharmacology*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D004809:Ephedrine