title: Infantile hemangioma of the liver in an adult: a case report and review of the literature.
abstract: Infantile hemangioma (IH), a representative vascular liver tumor, usually occurs in infancy or early childhood but rarely in adults. In this study, we describe a case of IH in a 47-year-old female and we also review the literature. A plain computed tomography (CT) image revealed five hypoattenuating masses in the liver. A dynamic study revealed the masses appeared to be well-enhanced in the arterial phase, and were considered to be high-flow hemangiomas. The tumors appeared as hypointense tumors on the T1-weighted images and as hyperintensities on fat-suppression T2-weighted images. Following the administration of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), tumors appeared to be well-enhanced in the arterial phase. In the portal phase, tumors demonstrated isointensity compared with the surrounding liver parenchyma, and hypointensity in the equilibrium and hepatobiliary phases. The apparent diffusion coefficient (ADC) values ranged from 2.0 to 2.4x10(-3) mm2/sec. Microscopically, the tumors were composed of numerous capillary-like small vessels lined with plump endothelial cells, arranged in a single layer without mitoses, and small bile ducts were trapped and scattered within the tumor. These findings were considered to be characteristic of IH. To the best of our knowledge, this case is the third report on IH in adults.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sumi
authors.forename: Jun
authors.initials: J
authors.lastname: Akiba
authors.forename: Shuji
authors.initials: S
authors.lastname: Nagata
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Tonan
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Nomura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ogata
authors.forename: Masafumi
authors.initials: M
authors.lastname: Uchida
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yano
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006391:Hemangioma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D003287:Contrast Media; D014746:Vimentin; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA