title: A new near infrared photosensitizing nanoplatform containing blue-emitting up-conversion nanoparticles and hypocrellin A for photodynamic therapy of cancer cells.
abstract: The utilization of up-conversion nanoparticles (UCNPs) for photodynamic therapy (PDT) has gained significant interest due to their unique ability to convert near infrared light to UV/visible light. Previous work mainly focused on the fabrication of green and red emitting UCNPs to load photosensitizers (PSs) for PDT. In this work, we firstly developed a new multifunctional nanoplatform combining blue-emitting UCNPs with blue-light excited PS (hypocrellin A, HA) as a NIR photosensitizing nanoplatform for PDT of cancer cells. Tween 20 coated NaYbF4:Tm, Gd@NaGdF4 UCNPs (Tween 20-UCNPs) with strong blue up-conversion luminescence and good water dispersibility were prepared for use as PS carriers. The blue emission band matched well with the efficient absorption band of HA, thereby facilitating the resonance energy transfer from UCNPs to HA and then activating HA to produce singlet oxygen ((1)O2). The in vitro study showed that these Tween 20-UCNPs@HA complexes could efficiently produce (1)O2 to kill cancer cells under 980 nm NIR excitation. Moreover, these Gd(3+) and Yb(3+) containing nanoparticles also exhibited positive contrast effects in both T1 weighted magnetic resonance imaging (MRI) and computed tomography (CT) imaging, making them become a multifunctional platform for simultaneous PDT and bio-imaging.
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China. zjgu@ihep.ac.cn zhaoyuliang@ihep.ac.cn.
authors.forename: Shan
authors.initials: S
authors.lastname: Jin
authors.forename: Liangjun
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
authors.forename: Gan
authors.initials: G
authors.lastname: Tian
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.forename: Wenlu
authors.initials: W
authors.lastname: Ren
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Hu
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D005459:Fluorides / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011136:Polysorbates / Q000737:chemistry; D011809:Quinones / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D011859:Radiography; D026082:Singlet Oxygen / Q000378:metabolism; D015019:Yttrium / Q000737:chemistry
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents; D011136:Polysorbates; D011809:Quinones; C525362:sodium yttriumtetrafluoride; D026082:Singlet Oxygen; D019800:Phenol; D015019:Yttrium; D010569:Perylene; D005682:Gadolinium; D005459:Fluorides; C048388:hypocrellin A