title: Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial.
abstract: OBJECTIVE
  This study aimed to determine the efficacy and safety of intralesional betamethasone in erosive oral lichen planus and to evaluate relapse of erosion.
  
  
  METHODS
  Patients were randomly assigned to the experimental group (1.4 mg intralesional betamethasone) or to the control group (8 mg intralesional triamcinolone acetonide), and they received injections once a week for 2 weeks. Erosive area and pain level were assessed on days 1, 7 ± 2, and 14 ± 2. If the lesion disappeared, any recurrence within the following 3 months was recorded.
  
  
  RESULTS
  Twenty-nine participants in the experimental group and 30 in the control group completed the protocol. Healed percentage was higher with betamethasone (93.1%) than with triamcinolone (66.7%; P = .02), and final reduction in erosion area was greater in the experimental group (21.276 ± 21.064 mm(2)) than in the control group (11.5 ± 12.95 mm(2); P = .02). Reduction in pain level did not differ between groups. The proportion of participants with recurrent erosions was significantly lower in the experimental group (14.8%) than in the control group (45%; P = .04).
  
  
  CONCLUSIONS
  Intralesional betamethasone may be used in the topical treatment of erosive oral lichen planus.
authors.affiliation: State Key Laboratory of Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Chuanxia
authors.initials: C
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Duanxian
authors.initials: D
authors.lastname: Lin
authors.forename: Caixia
authors.initials: C
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Ge
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015552:Injections, Intralesional; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012008:Recurrence; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone; D014222:Triamcinolone Acetonide