title: Retrospective assessment of the utility of an iron-based agent for contrast-enhanced magnetic resonance venography in patients with endstage renal diseases.
abstract: OBJECTIVE
  To compare abdominopelvic and lower extremity venous enhancement in contrast-enhanced magnetic resonance venography (ceMRV), using iron-based ferumoxytol and gadolinium-based gadofosveset.
  
  
  METHODS
  This was a Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study. Thirty-four patients were identified who had undergone ceMRV using either ferumoxtyol (Group A, all with chronic renal insufficiency) or gadofosveset (Group B). Two radiologists rated confidence for evaluation of the major abdominopelvic and lower extremity veins from 4 (excellent confidence) to 1 (nondiagnostic). A third radiologist measured signal intensity ratios (SIRs) of venous segments compared with adjacent muscles. Scores were compared using repeated-measures analysis of variance (ANOVA). The medical record was searched for contemporaneous imaging to confirm the ceMRV findings.
  
  
  RESULTS
  In Group A, 14/225 venous segments were thrombosed, compared with 18/282 in Group B. There was no statistically significant difference between confidence scores (3.79 ± 0.44 vs. 3.85 ± 0.44, P = 0.34) or SIRs (2.40 ± 0.73 vs. 2.38 ± 0.51, P = 0.51) for patent segments in the two groups, nor were confidences scores (3.89 ± 0.29 vs. 3.72 ± 0.46, P = 0.31) or SIRs (0.90 ± 0.12 vs. 0.84 ± 0.19, P = 0.31) significantly different for thrombosed segments. Contemporaneous imaging confirmed ceMRV findings in 227 segments.
  
  
  CONCLUSIONS
  ceMRV can be performed with ferumoxytol, yielding similar image quality to a blood pool gadolinium-based contrast agent.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Mustafa R
authors.initials: MR
authors.lastname: Bashir
authors.forename: Rekha
authors.initials: R
authors.lastname: Mody
authors.forename: Amy
authors.initials: A
authors.lastname: Neville
authors.forename: Ramin
authors.initials: R
authors.lastname: Javan
authors.forename: Danielle
authors.initials: D
authors.lastname: Seaman
authors.forename: Charles Y
authors.initials: CY
authors.lastname: Kim
authors.forename: Rajan T
authors.initials: RT
authors.lastname: Gupta
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Jaffe
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D058085:Iron Compounds; D007676:Kidney Failure, Chronic / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds; D010690:Phlebography / Q000379:methods*; D012077:Renal Artery / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D058085:Iron Compounds; D009942:Organometallic Compounds; D005682:Gadolinium; D052203:Ferrosoferric Oxide; C109932:gadofosveset trisodium
keywords: DVT; SPIO; deep vein thrombosis; ferumoxytol