title: [Advance in the study of myocardial ischemic preconditioning and postconditioning and the clinical applications].
abstract: Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, protect coronary endothelial and myocardial cell ultrastructure, as well as reduce the incidence of arrhythmias. Clinical practice has confirmed the safety and efficacy of these two methods of myocardial protection. This paper reviewed about ischemic preconditioning and postconditioning protection mechanisms in myocardial ischemia reperfusion injury and clinical research literatures in recent years, to provide a theoretical basis for finding new treatment strategies on the prevention and treatment of ischemic cardiomyopathy.
authors.affiliation: Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Wu
authors.forename: Lian-Hua
authors.initials: LH
authors.lastname: Fang
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D000818:Animals; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D009203:Myocardial Infarction / Q000628:therapy; D017202:Myocardial Ischemia / Q000628:therapy; D015425:Myocardial Reperfusion / Q000009:adverse effects; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled