title: Sequential processing deficits in schizophrenia: relationship to neuropsychology and genetics.
abstract: Utilizing a combination of neuropsychological and cognitive neuroscience approaches may be essential for characterizing cognitive deficits in schizophrenia and eventually assessing cognitive outcomes. This study was designed to compare the stability of select exemplars for these approaches and their correlations in schizophrenia patients with stable treatment and clinical profiles. Reliability estimates for serial order processing were comparable to neuropsychological measures and indicate that experimental serial order processing measures may be less susceptible to practice effects than traditional neuropsychological measures. Correlations were moderate and consistent with a global cognitive factor. Exploratory analyses indicated a potentially critical role of the Met allele of the Catechol-O-methyltransferase (COMT) Val158Met polymorphism in externally paced sequential recall. Experimental measures of serial order processing may reflect frontostriatal dysfunction and be a useful supplement to large neuropsychological batteries.
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States. Electronic address: scot.hill@rosalindfranklin.edu.
authors.forename: S Kristian
authors.initials: SK
authors.lastname: Hill
authors.forename: Olivia
authors.initials: O
authors.lastname: Bjorkquist
authors.forename: Tarra
authors.initials: T
authors.lastname: Carrathers
authors.forename: Jarett E
authors.initials: JE
authors.lastname: Roseberry
authors.forename: William C
authors.initials: WC
authors.lastname: Hochberger
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Bishop
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003072:Cognition Disorders; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D012044:Regression Analysis; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000150:complications* / Q000235:genetics*; D012565:Schizophrenic Psychology; D012691:Serial Learning / Q000502:physiology
chemical_list: D002394:Catechol O-Methyltransferase
keywords: COMT; Neuropsychology; Reliability; Serial order processing; Working memory