title: New pterosin sesquiterpenes and antitubercular constituents from Pteris ensiformis.
abstract: Two new pterosin sesquiterpenes, (2S)-13-hydroxypterosin A (1) and (2S,3S)-12-hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D-NMR and MS analyses. Compound 2 exhibited antitubercular activity (MIC 6.25 μg/ml) against Mycobacterium tuberculosis H37 Rv in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan (phone: +886-8-7624002 (ext. 2827); fax: +886-8-7624002 (ext. 5121)). jjchen@mail.tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Tai-Chi
authors.initials: TC
authors.lastname: Wang
authors.forename: Chieh-Kai
authors.initials: CK
authors.lastname: Yang
authors.forename: Hsiang-Ruei
authors.initials: HR
authors.lastname: Liao
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Jinn-Fen
authors.initials: JF
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007189:Indans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D032495:Pteris / Q000737:chemistry* / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C588293:12-hydroxypterosin Q; D000995:Antitubercular Agents; D007189:Indans; D010936:Plant Extracts; D012717:Sesquiterpenes; C010772:pterosin
keywords: Antitubercular activity; Pteris ensiformis; Pterosin sesquiterpenes; Sesquiterpenes