title: Reversible chemical restraint of free-range cattle with a concentrated combination of tiletamine-zolazepam, ketamine, and detomidine.
abstract: The aim of this study was to determine the efficacy of a concentrated combination of tiletamine-zolazepam [TZ, 0.53 mg/kg body weight (BW)], ketamine (Ket, 0.53 mg/kg BW), and detomidine (Det, 0.04 mg/kg BW) in the immobilization of free-range cattle for clinical procedures. The combination was administered intramuscularly to 53 animals. Anesthesia was reversed with the α2-adrenoceptor antagonist atipamezole. Locoregional anesthesia was provided with lidocaine when required. The TZKD combination induced suitable immobilization for minor surgical procedures or medical treatments. Anesthetic onset was rapid, taking a mean of 6.1 min [standard deviation (SD) 2.8 min]. The duration of anesthesia depended on the time of administration of the antagonist; the animals recovered in the standing position in 12.9 ± 8.9 min after the administration of atipamezole. The quality of anesthesia and analgesia were satisfactory. In conclusion, this TZKD combination can be used for both immobilization and minor surgical procedures in free-range cattle.
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary Faculty, University Complutense, Avda, Puerta de Hierro s/n. 28040, Madrid, Spain (Re, Blanco-Murcia, Gómez de Segura); Pfizer Animal Health, Alcobendas, Spain (San Miguel).
authors.forename: Michela
authors.initials: M
authors.lastname: Re
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Blanco-Murcia
authors.forename: José Maria
authors.initials: JM
authors.lastname: San Miguel
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Gómez de Segura
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D000818:Animals; D002417:Cattle / Q000601:surgery*; D004338:Drug Combinations; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D007103:Immobilization / Q000379:methods / Q000662:veterinary*; D007649:Ketamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D008297:Male; D011446:Prospective Studies; D013992:Tiletamine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D015041:Zolazepam / Q000008:administration & dosage* / Q000037:antagonists & inhibitors
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; D007093:Imidazoles; C006131:tiletamine, zolazepam drug combination; C050701:atipamezole; D013992:Tiletamine; D007649:Ketamine; C041255:detomidine; D015041:Zolazepam