title: Oral mucosal injury in oncology patients: perspectives on maturation of a field.
abstract: In the past decade, there have been important strategic advances relative to pathobiological modeling as well as clinical management for oral mucositis caused by cancer therapies. Prior to the 1990s, research in this field was conducted by a relatively small number of basic and clinical investigators. Increasing interest among researchers and clinicians over the past twenty years has produced a synergistic outcome characterized by a number of key dynamics, including novel discovery models for pathobiology, increased experience in designing and conducting clinical trials, and creation of international collaborations among cancer care professionals who in turn have modeled clinical care paradigms based on state-of-the-science evidence. This maturation of the science and its clinical translation has positioned investigators and oncology providers to further accelerate both the foundational research and the clinical modeling for patient management in the years ahead. The stage is now set to further capitalize upon optimizing the interactions across this interface, with the goal of strategically enhancing management of patients with cancer at risk for this toxicity while reducing the cost of cancer care.
authors.affiliation: Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA; Program in Head & Neck Cancer and Oral Oncology, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Peterson
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
authors.forename: R V
authors.initials: RV
authors.lastname: Lalla
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects; D009061:Mouth Mucosa / Q000293:injuries*; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D019226:Oral Ulcer / Q000209:etiology / Q000473:pathology; D013280:Stomatitis / Q000209:etiology* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents
keywords: cancer therapy; clinical practice guidelines; mucosal injury; mucositis