title: Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken.
abstract: The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D1 antagonist; 2.5, 5 and 10 nmol), AMI-193 (D2 antagonist; 2.5, 5 and 10 nmol), NGB2904 (D3 antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D4 antagonist; 1.5, 3 and 6 nmol) on food intake in FD3 chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT1A agonist; 15.25 nmol) and SB242084 (5-HT2C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p<0.05). The inhibitory effect of dopamine on food intake was decreased by SCH 23390 pretreatment (P<0.05), but AMI-193, NGB2904 and L-741, 742 had no effect on food intake induced by dopamine. In addition, hypophagic effect of dopamine was attenuated by SB242084 (P<0.05), but 8-OH-DPAT had no effect. These results suggest that dopamine decrease food intake via D1 receptor and there is an interaction between dopaminergic and serotonergic systems via 5-HT2C receptor in chickens.
authors.affiliation: Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran, zendedel@ut.ac.ir.
authors.forename: Morteza
authors.initials: M
authors.lastname: Zendehdel
authors.forename: Keyvan
authors.initials: K
authors.lastname: Hasani
authors.forename: Vahab
authors.initials: V
authors.lastname: Babapour
authors.forename: Sepideh Seyedali
authors.initials: SS
authors.lastname: Mortezaei
authors.forename: Yalda
authors.initials: Y
authors.lastname: Khoshbakht
authors.forename: Shahin
authors.initials: S
authors.lastname: Hassanpour
mesh_terms: D000818:Animals; D002645:Chickens; D004298:Dopamine / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011897:Random Allocation; D017447:Receptors, Dopamine D1 / Q000378:metabolism*
chemical_list: D018377:Neurotransmitter Agents; D017447:Receptors, Dopamine D1; D004298:Dopamine