title: Combined paclitaxel-eluting balloon and Genous cobalt-chromium alloy stent utilization in de novo coronary stenoses (PEGASUS).
abstract: OBJECTIVE
  The aim of this study was to examine the angiographic result and its outcome predictors using the combination of paclitaxel-eluting balloon (PEB) and Genous stent.
  
  
  BACKGROUND
  This approach to treat coronary stenoses is a logical strategy to strike a balance between minimizing restenosis and stent thrombosis.
  
  
  METHODS
  From November 2010 to June 2012, 40 symptomatic patients with 44 de novo coronary lesions of diameter stenosis ≥ 50% were treated with the combination of PEB and Genous stents. Angiographic and clinical follow-up were intended at 6 and 9 months, respectively.
  
  
  RESULTS
  The mean age of patients was 61 ± 11 years, with male predominance (83%). Diabetes mellitus and end-stage renal failure on peritoneal dialysis were found in 15 (38%) and 10 (25%) patients, respectively. Patients received dual antiplatelet therapy for 5.1 ± 1.5 months post procedure. The size and length of PEB used was larger than the stents (3.13 ± 0.46 mm and 28 ± 9 mm vs. 2.98 ± 0.36 mm and 23 ± 7 mm). Restudy angiography was performed on 41 (95%) lesions in 37 (93%) patients at 5.9 ± 1.7 months. Angiographic restenosis was seen in 5 (12%) lesions, and significantly associated with diabetes mellitus and dialysis dependency; the late lumen loss was 0.38 ± 0.37 mm. At 9-month follow-up, no stent thrombosis was observed.
  
  
  CONCLUSIONS
  The use of PEB combined with Genous stent is associated with a reasonably low restenosis and late lumen loss, whereas diabetes mellitus and renal failure with dialysis are poor predictors of angiographic restenosis.
authors.affiliation: Cardiac Medical Unit, Grantham Hospital, Hong Kong, Hong Kong.
authors.forename: Man-Hong
authors.initials: MH
authors.lastname: Jim
authors.forename: Raymond Chi-Yan
authors.initials: RC
authors.lastname: Fung
authors.forename: Kai-Hang
authors.initials: KH
authors.lastname: Yiu
authors.forename: Andrew Kei-Yan
authors.initials: AK
authors.lastname: Ng
authors.forename: Chung-Wah
authors.initials: CW
authors.lastname: Siu
authors.forename: Katherine Yu-Yan
authors.initials: KY
authors.lastname: Fan
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D002858:Chromium Alloys; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control; D023921:Coronary Stenosis / Q000628:therapy*; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects
chemical_list: D002858:Chromium Alloys; D017239:Paclitaxel