title: An update on the importance of monitoring serum magnesium in advanced disease patients.
abstract: OBJECTIVE
  Patients with advanced diseases are exposed to many causes of hypomagnesaemia, the most frequent being pharmacological causes through the administration of chemotherapy, antibiotics, proton pump inhibitors, and so on. The objective of this review is to demonstrate the importance of measuring magnesium levels in the blood of these patients.
  
  
  RESULTS
  In the last decade, studies have been published showing a direct relationship between low levels of magnesium and nonspecific symptoms including pain that is difficult to control. Nevertheless, hypomagnesaemia is still being omitted as a differential diagnosis in many such patients.
  
  
  CONCLUSIONS
  A review of recently published studies regarding the clinical presentation of hypomagnesaemia in patients with advanced cancer and other chronic diseases is presented. Many of the clinical conditions are reportedly alleviated with intravenous or even oral magnesium administration. The presence of nonspecific neurological signs and risk factors for hypomagnesaemia could serve as an indication that serum magnesium should be determined in these patients.
authors.affiliation: aPalliative Care Unit, Clinic University of Navarra bUniversity of Navarra, Institute for Culture and Society (ICS), ATLANTES Research Program: Human Dignity, Advance Disease and Palliative Care, Pamplona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Centeno
authors.forename: José Mario
authors.initials: JM
authors.lastname: López Saca
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D016638:Critical Illness; D006801:Humans; D008274:Magnesium / Q000097:blood* / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000097:blood / Q000139:chemically induced / Q000150:complications*; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D009422:Nervous System Diseases / Q000209:etiology; D010146:Pain / Q000209:etiology; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D054328:Proton Pump Inhibitors; D008274:Magnesium; D002945:Cisplatin