title: [In vitro study over statins effects on cellular growth curves and its reversibility with mevalonate].
abstract: HMG-CoA-Reductase inhibitors, also known as statins, are currently the most powerful cholesterol-lowering drugs available on the market. Clinical trials and experimental evidence suggest that statins have heavy anti-atherosclerotic effects. These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. These so-called pleiotropic properties affect various aspects of cell function, inflammation, coagulation, and vasomotor activity. These effects are mediated either indirectly through LDL-c reduction or via a direct effect on cellular functions. Although many of the pleiotropic properties of statins may be a class effect, some may be unique to certain agents and account for differences in their pharmacological activity. So, although statins typically have similar effects on LDL-c levels, differences in chemical structure and pharmacokinetic profile can lead to variations in pleiotropic effects. In this paper we analize the in vitro effects of different statins over different cell lines from cells implicated in atherosclerotic process: endothelial cells, fibroblasts, and vascular muscular cells. In relation with our results we can proof that the effects of different dosis of different statins provides singular effects over growth curves of different cellular lines, a despite of a class-dependent effects. So, pleiotropic effects and its reversibility with mevalonate are different according with the molecule and the dosis.
authors.affiliation: Servicio de Medicina Interna, Unidad de Riesgo Cardiovascular y Lïpidos, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España. Electronic address: jesus.millan@salud.madrid.org.
authors.forename: Jesús
authors.initials: J
authors.lastname: Millan Núñez-Cortés
authors.affiliation: Laboratorio de Investigación Biomédica, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Ysmael
authors.initials: Y
authors.lastname: Alvarez Rodriguez
authors.affiliation: Laboratorio de Investigación Biomédica, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Granada
authors.initials: G
authors.lastname: Alvarez Novés
authors.affiliation: Servicio de Medicina Interna, Unidad de Riesgo Cardiovascular y Lïpidos, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Recarte Garcia-Andrade
authors.affiliation: Servicio de Medicina Interna, Unidad de Riesgo Cardiovascular y Lïpidos, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Alvarez-Sala Walther
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology; D050197:Atherosclerosis / Q000188:drug therapy / Q000473:pathology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D008798:Mevalonic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008798:Mevalonic Acid
keywords: Cellular growth; Crecimiento celular; Efectos pleiotrópicos; Estatinas; Pleiotropic effects; Statins