title: Small bowel obstruction in patients with a prior history of cancer: predictive findings of malignant origins.
abstract: BACKGROUND
  Determining the cause of acute small bowel obstruction (SBO) in patients previously treated for cancer is necessary for adequate management, especially to avoid incorrectly classing the patient as palliative. We aimed to identify predictive factors for a malignant or a benign origin of SBO.
  
  
  METHODS
  We retrospectively studied data for all patients with a prior history of cancer who had undergone operations for SBO between January 2002 and December 2011. Of the 124 patients included, 36 patients had a known cancer recurrence before surgery for SBO, whereas 88 had none.
  
  
  RESULTS
  Causes of SBO were benign (post-operative adhesions, post-irradiation strictures) in 68 patients (54.8 %) and malignant in 56 (45.2 %). Incomplete obstruction, acute clinical onset, non-permanent abdominal pain, a shorter period between primary cancer surgery and the first episode of obstruction, and a known cancer recurrence were significant predictors of a malignant SBO. Benign causes of SBO were observed in 72.8 % of patients who had no known cancer recurrence, but were observed in only 11.1 % of patients whose recurrences were known. In patients with cancer recurrence-related SBO, post-operative mortality was 28.6 %, with a median overall survival of 120 days. 1 month after surgery, 38 (67.8 %) of these patients tolerated oral intake.
  
  
  CONCLUSIONS
  A benign cause of SBO was observed in half of the patients with a prior history of cancer and in two-thirds of those without known recurrence. Even in the absence of bowel strangulation, surgery must be considered soon after failure of medical management to treat a possible adhesion-related SBO.
authors.affiliation: Department of General and Digestive Surgery, Avicenne AP-HP University Hospital, 125, rue de Stalingrad, 93009, Bobigny, France.
authors.forename: J
authors.initials: J
authors.lastname: Prost À la Denise
authors.forename: R
authors.initials: R
authors.lastname: Douard
authors.forename: G
authors.initials: G
authors.lastname: Malamut
authors.forename: F
authors.initials: F
authors.lastname: Mecheri
authors.forename: P
authors.initials: P
authors.lastname: Wind
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003251:Constriction, Pathologic; D004067:Digestive System Neoplasms / Q000453:epidemiology; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology; D006801:Humans; D007415:Intestinal Obstruction / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology*; D014571:Urologic Neoplasms / Q000453:epidemiology