title: Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment.
abstract: OBJECTIVE
  The purpose of this study was to examine the therapeutic effect of magnetic nanoparticle hyperthermia (mNPH) combined with systemic cisplatin chemotherapy in a murine mammary adenocarcinoma model (MTGB).
  
  
  METHODS
  An alternating magnetic field (35.8 kA/m at 165 kHz) was used to activate 110 nm hydroxyethyl starch-coated magnetic nanoparticles (mNP) to a thermal dose of 60 min at 43 °C. Intratumoral mNP were delivered at 7.5 mg of Fe/cm(3) of tumour (four equal tumour quadrants). Intraperitoneal cisplatin at 5 mg/kg body weight was administered 1 h prior to mNPH. Tumour regrowth delay time was used to assess the treatment efficacy.
  
  
  RESULTS
  mNP hyperthermia, combined with cisplatin, was 1.7 times more effective than mNP hyperthermia alone and 1.4 times more effective than cisplatin alone (p < 0.05).
  
  
  CONCLUSIONS
  Our results demonstrate that mNP hyperthermia can result in a safe and significant therapeutic enhancement for cisplatin cancer therapy.
authors.affiliation: Thayer School of Engineering, Dartmouth College , Hanover, New Hampshire and.
authors.forename: Alicia A
authors.initials: AA
authors.lastname: Petryk
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Giustini
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Gottesman
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kaufman
authors.forename: P Jack
authors.initials: PJ
authors.lastname: Hoopes
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D051379:Mice; D008809:Mice, Inbred C3H; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D002945:Cisplatin