title: Factors associated with conversion of long-term non-progressors to progressors: a prospective study of HIV perinatally infected paediatric survivors.
abstract: OBJECTIVE
  Survival pattern among children infected with the human immune deficiency virus (HIV) follows a bimodel distribution. Some children survive beyond 9 years age and are known as long term survivors (LTS) while others had a more rapid course to death during the first few years of life. In the LTS group of children, two sub-populations have emerged, the long term non-progressors (LTNP) who have remained asymptomatic over a period of years and those who have survived despite clinical and laboratory evidence of disease progression, the long term progressors (LTP). The aim of the present study was to determine the factors influencing the conversion of LTNPs to LTPs in a group of perinatally HIV infected children who were followed up for five years.
  
  
  METHODS
  A total of 26 HIV seropositive paediatric patients were monitored from 2006 to 2011 with CD4 cell counts, onset of clinical manifestations, body weight, biochemical, haematological and immunological parameters. Statistical analyses, both qualitative and quantitative, were used to determine the degree of conversion of non-progressors to progressors.
  
  
  RESULTS
  All 26 (13 female and 13 male) perinatally HIV infected children, born during 1991-1996 were healthy until 2006. But by 2011, 18 were placed in progressors group with antiretroviral therapy (ART), while six remained in non progressors group and two died. As per the Kaplan-Meier survival analysis, AIDS free median survival period (years) in LTP group (CD4 count) of the cohort was 10 ± 0.66 (<200; P=<0.05); 11 ± 0.61 (200-350, P=<0.05), 12 ± 0.18 (>350, P=<0.05). Intercurrent and opportunistic infections (OIs) were observed in LTPs only. The incidence of OI in LTPs was higher when compared to general paediatric population.
  
  
  CONCLUSIONS
  Our findings show that CD4 counts and OIs play an important role in influencing the survival chances of perinatally HIV infected children.
authors.affiliation: Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India.
authors.forename: Muttineni
authors.initials: M
authors.lastname: Radhakrishna
authors.forename: Kharidehal
authors.initials: K
authors.lastname: Durga
authors.forename: Ravilla Kondal
authors.initials: RK
authors.lastname: Rao
authors.forename: Doodipala Mallikarjuna
authors.initials: DM
authors.lastname: Reddy
authors.forename: Anand Kumar
authors.initials: AK
authors.lastname: Kondapi
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015658:HIV Infections / Q000503:physiopathology*; D020276:HIV Long-Term Survivors; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011446:Prospective Studies