title: Acute bilateral ureteral obstruction secondary to guaifenesin toxicity.
abstract: Several medications or their metabolites have been associated with urolithiasis, although overall they remain an infrequent cause of urolithiasis. Guaifenesin stones were originally reported as complexed with ephedrine, and subsequent reports have demonstrated pure guaifenesin stones, occurring after long term abuse. We report a case of a 23-year-old male who ingested a large, one time dose of guaifenesin, resulting in acute bilateral ureteral obstruction, which, to our knowledge, is the first such reported case in the literature.
authors.affiliation: Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Cockerill
authors.forename: Mitra R
authors.initials: MR
authors.lastname: de Cógáin
authors.forename: Amy E
authors.initials: AE
authors.lastname: Krambeck
mesh_terms: D000208:Acute Disease; D003558:Cystoscopy; D062787:Drug Overdose; D006140:Guaifenesin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000139:chemically induced* / Q000175:diagnosis* / Q000601:surgery; D052878:Urolithiasis / Q000139:chemically induced* / Q000175:diagnosis* / Q000601:surgery; D055815:Young Adult
chemical_list: D006140:Guaifenesin