title: [Clinical features and treatment of acute clenbuterol poisoning in children].
abstract: OBJECTIVE
  To study clinical features, treatment and curative effects in children with acute clenbuterol poisoning, in order to provide a basis for early diagnosis and treatment.
  
  
  METHODS
  Clinical data of 28 hospitalized children with acute clenbuterol poisoning in April 2011 were retrospectively studied.
  
  
  RESULTS
  Of the 28 patients, there were 15 males and 13 females, aged 1 to 13 years (mean age 6.5±4.8 years). Vomiting, palpitations and limb shaking were found as main clinical manifestations in the patients. Main changes of blood biochemical included hypokalemia, lactic acidosis, hyperglycemia, hypsocreatinkinase. Snus tachycardia and S-T segment depression were observed on ECG. Patients' symptoms were gradually alleviated after 12-78 hours by use of beta blockers, potassium supplement, protecting the heart and other symptomatic and supportive treatment. Blood biochemical indexes were improved after 48 hours of admission. All of the patients were cured after 5 days. The symptoms of the patients do not longer occur during a follow up of half a month.
  
  
  CONCLUSIONS
  Acute clenbuterol poisoning is characterized by vomiting, palpitations, limb shaking, hypokalemia, lactic acidosis and tachycardia in children. An early effective treatment of this disease can improve prognosis in children.
authors.affiliation: Hepatic Center, Hunan Children's Hospital, Changsha 410011, China. 1478300920@qq.com.
authors.forename: Wen-Xian
authors.initials: WX
authors.lastname: Ou-Yang
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Lu
authors.forename: Si-Jing
authors.initials: SJ
authors.lastname: Yu
authors.forename: Chuan-Zhong
authors.initials: CZ
authors.lastname: Ding
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Ding
authors.forename: Fu-Rong
authors.initials: FR
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Tang
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D002976:Clenbuterol / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D000318:Adrenergic beta-Agonists; D002976:Clenbuterol