title: Non-specific dsRNA-mediated antiviral response in the honey bee.
abstract: Honey bees are essential pollinators of numerous agricultural crops. Since 2006, honey bee populations have suffered considerable annual losses that are partially attributed to Colony Collapse Disorder (CCD). CCD is an unexplained phenomenon that correlates with elevated incidence of pathogens, including RNA viruses. Honey bees are eusocial insects that live in colonies of genetically related individuals that work in concert to gather and store nutrients. Their social organization provides numerous benefits, but also facilitates pathogen transmission between individuals. To investigate honey bee antiviral defense mechanisms, we developed an RNA virus infection model and discovered that administration of dsRNA, regardless of sequence, reduced virus infection. Our results suggest that dsRNA, a viral pathogen associated molecular pattern (PAMP), triggers an antiviral response that controls virus infection in honey bees.
authors.affiliation: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America ; Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, Montana, United States of America.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Flenniken
authors.forename: Raul
authors.initials: R
authors.lastname: Andino
mesh_terms: D000818:Animals; D001516:Bees / Q000235:genetics / Q000276:immunology / Q000821:virology*; D056631:Colony Collapse / Q000517:prevention & control / Q000821:virology*; D005786:Gene Expression Regulation; D063990:Gene Ontology; D007109:Immunity; D012328:RNA Viruses / Q000235:genetics* / Q000276:immunology; D012330:RNA, Double-Stranded / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology
chemical_list: D012330:RNA, Double-Stranded