title: Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines.
abstract: Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic agent capable of inducing tumor cell death in a variety of cancer types. However, therapeutic application of these beneficial effects remains very limited due to its short biological half-life, labile properties, rapid metabolism and elimination. Different studies were undertaken to obtain synthetic analogs of resveratrol with major bioavailability and anticancer activity. We have synthesized a series 3-chloro-azetidin-2-one derivatives, in which an azetidinone nucleus connects two aromatic rings. Aim of the present study was to investigate the effects of these new 3-chloro-azetidin-2-one resveratrol derivatives on human breast cancer cell lines proliferation. Our results indicate that some azetidin-based resveratrol derivatives may become new potent alternative tools for the treatment of human breast cancer.
authors.affiliation: Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.
authors.forename: Adele
authors.initials: A
authors.lastname: Chimento
authors.forename: Marina
authors.initials: M
authors.lastname: Sala
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Gomez-Monterrey
authors.forename: Simona
authors.initials: S
authors.lastname: Musella
authors.forename: Alessia
authors.initials: A
authors.lastname: Bertamino
authors.forename: Anna
authors.initials: A
authors.lastname: Caruso
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Sinicropi
authors.forename: Rosa
authors.initials: R
authors.lastname: Sirianni
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.forename: Ortensia Ilaria
authors.initials: OI
authors.lastname: Parisi
authors.forename: Carmela
authors.initials: C
authors.lastname: Campana
authors.forename: Emilia
authors.initials: E
authors.lastname: Martire
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Carmela
authors.initials: C
authors.lastname: Saturnino
authors.forename: Pietro
authors.initials: P
authors.lastname: Campiglia
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pezzi
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000627:therapeutic use*; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001384:Azetidines; D013267:Stilbenes; D000077185:Resveratrol
keywords: 3-Chloro-azetidin-2-one derivatives; Breast cancer; MCF-7; Resveratrol analogs anticancer drugs; SKBR3