title: Regioselective halogenation of 2-substituted-1,2,3-triazoles via sp2 C-H activation.
abstract: A highly regioselective halogenation of 2-substituted-1,2,3-triazoles was developed via sp(2) C-H activation. This method is compatible with halogen atoms, as well as electron-donating and electron-withdrawing groups. Meanwhile, the strategy is also efficient for the synthesis of a key intermediate of Suvorexant.
authors.affiliation: Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, China.
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Tian
authors.forename: Xianmin
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Zechao
authors.initials: Z
authors.lastname: Wang
authors.forename: Suping
authors.initials: S
authors.lastname: Shi
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Kuang
mesh_terms: D004583:Electrons; D054879:Halogenation; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D014230:Triazoles