title: Functions, aberrations, and advances for chromatin modulation in cancer.
abstract: Cancer initiation and progression is causally connected to genome and epigenome deregulations. Epigenetic deregulations (such as DNA methylation, histone modifications, and miRNA-based modulation) have been increasingly reported in tumorigenesis and different chromatin-modulating enzymes have been discovered and classified and their aberrations connected to cancer. A better insight into alterations occurring on chromatin enzymes and their impact in cancer thus represents a crucial step in exploiting epigenetic targeting in cancer prevention and treatment.
authors.affiliation: Dipartimento di Biochimica, Biofisica e Patologia generale, Seconda Università di Napoli, Vico L. De Crecchio 7, 80138, Naples, Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Conte
authors.forename: Lucia
authors.initials: L
authors.lastname: Altucci
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000235:genetics*; D002869:Chromosome Aberrations; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D002843:Chromatin