title: Sculpting the nucleus with dynamic microtubules.
abstract: How nuclear morphology is regulated during development and disease remains poorly understood. In this issue of Developmental Cell, using a pronuclear assembly assay, Xue et al. (2013) demonstrate that Dppa2, a chromatin-bound microtubule regulator, controls both the morphology and function of the pronucleus by fine-tuning microtubule dynamics.
authors.affiliation: Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA.
authors.forename: Yuxuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Yixian
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*
chemical_list: D002843:Chromatin; C584866:Dppa2 protein, Xenopus; D009687:Nuclear Proteins; D029867:Xenopus Proteins