title: Human immature dental pulp stem cells (hIDPSCs), their application to cell therapy and bioengineering: an analysis by systematic revision of the last decade of literature.
abstract: During recent years, attention has been given to the potential of therapeutic approaches using stem cells obtained from dental pulp tissue. The aim of this study, therefore, was to give an overview of the papers produced during the last 10 years that have described the use of stem cells obtained from human deciduous teeth in cell therapy or bioengineering. The PubMed database was investigated from January 2002 until July 2011 and the papers published during this period were analyzed according to criteria previously established, using the methodology of systematic review. The measurements were done using "stem cell" as the primary keyword, and "human deciduous teeth dental pulp cell" and "human exfoliated deciduous teeth" as the secondary keywords. Four hundred and seventy-five papers were found. The first screening resulted in 276 papers, from which 84 papers were selected. However, only 11 of them attained the aim proposed in our approach. There were few scientific studies related to direct therapeutic application using stem cells of human deciduous teeth and none of them had been applied to humans. However, the results indicated important and promising applications of the pulp stem-cells in cell therapy and bioengineering as demonstrated by studies in animal models of muscular dystrophy, Parkison's disease, and lupus erythematosus.
authors.affiliation: Departamento de Odontologia, Molecular e Genética, Universidade Estadual de Ponta Grossa, Brasil.
authors.forename: Priscilla Vianna
authors.initials: PV
authors.lastname: de Souza
authors.forename: Fabiana Bucholdz Teixeira
authors.initials: FB
authors.lastname: Alves
authors.forename: Cristina Lucia Sant'Ana
authors.initials: CL
authors.lastname: Costa Ayub
authors.forename: Maria Albertina
authors.initials: MA
authors.lastname: de Miranda Soares
authors.forename: Jose Rosa
authors.initials: JR
authors.lastname: Gomes
mesh_terms: D057005:Bioengineering; D001847:Bone Diseases / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D003782:Dental Pulp / Q000166:cytology*; D006801:Humans; D012196:Review Literature as Topic; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014094:Tooth, Deciduous / Q000166:cytology*
keywords: bioengineering; dental pulp; human; immature stem cell; therapy