title: Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians.
abstract: There were a number of studies performed to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians, but no consensus was available up to now. We conducted a meta-analysis to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians. Case-control studies investigating the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians were searched in Pubmed and Wanfang databases. Pooled odds ratio (OR) and 95% confidence interval (95% CI) was calculated. Finally, seven studies involving a total of 2,051 cases and 2,798 controls met the inclusion criteria and were included into the meta-analysis. Overall, there was an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians (Ser versus Pro: OR = 1.42, 95% CI 1.08-1.87, P = 0.013; SerSer versus ProPro: OR = 1.86, 95% CI 1.08-3.19, P = 0.024; SerSer/ProSer versus ProPro: OR = 1.61, 95% CI 1.10-2.35, P = 0.014; SerSer versus ProPro/ProSer: OR = 1.46, 95% CI 1.02-2.10, P = 0.041). There was low risk of publication bias in the meta-analysis. This meta-analysis suggests that there is an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians.
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200097, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Meng
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human