title: Analgesic effect of sinomenine in rodents after inflammation and nerve injury.
abstract: Sinomenine is an alkaloid originally isolated from the root of the plant Sinomenium acutum. It is used in traditional medicine in China to treat rheumatic arthritis. In the present study, we evaluated the potential antinociceptive effects of sinomenine in rodents with nociceptive, inflammatory and neuropathic pain. In normal rats and mice, systemic sinomenine produced moderate antinociceptive effect in the hot plate and tail flick tests. Sinomenine also exerted analgesic effects on mechanical and heat hypersensitivity in mice after carrageenan induced inflammation. Finally, sinomenine effectively alleviated mechanical and cold allodynia in rats and mice after injury to peripheral nerve or spinal cord. The analgesic effect of sinomenine is not associated with side effects and is not reversed by the opioid receptor antagonist naloxone. Our results showed that sinomenine has a wide spectrum analgesic effect in rodent models of nociceptive, inflammatory and neuropathic pain.
authors.affiliation: Department of Physiology and Pharmacology, Section of Integrative Pain Research, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Tianle
authors.initials: T
authors.lastname: Gao
authors.forename: Jingxia
authors.initials: J
authors.lastname: Hao
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Wiesenfeld-Hallin
authors.forename: Dan-Qiao
authors.initials: DQ
authors.lastname: Wang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Xu
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan / Q000009:adverse effects; D005260:Female; D006930:Hyperalgesia / Q000150:complications / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D009019:Morphinans / Q000494:pharmacology* / Q000627:therapeutic use; D009437:Neuralgia / Q000150:complications / Q000188:drug therapy; D059225:Nociception / Q000187:drug effects; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries*; D013119:Spinal Cord Injuries / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000700:Analgesics; D009019:Morphinans; C009271:sinomenine; D002351:Carrageenan
keywords: Analgesia; Herbal medicine; Morphine; Neuropathic pain; Sinomenine