title: Impact of abdominal obesity and ambulatory blood pressure in the diagnosis of left ventricular hypertrophy in never treated hypertensives.
abstract: OBJECTIVE
  The principal objective was to assess the prevalence of left ventricular hypertrophy (LVH) in hypertensive, never treated patients, depending on adjustment for body surface or height. Secondary objectives were to determine geometric alterations of the left ventricle and to analyze the interdependence of hypertension and obesity to induce LVH.
  
  
  METHODS
  Cross-sectional study that included 750 patients (387 men) aged 47 (13, SD) years who underwent ambulatory blood pressure (ABPM) monitoring and echocardiography.
  
  
  RESULTS
  The prevalence of LVH was 40.4% (303 patients), adjusted for body surface area (BSA, LVHBSA), and 61.7% (463 patients), adjusted for height(2.7) (LVHheight(2.7)). In a multivariate logistic analysis, systolic BP24h, gender and presence of elevated microalbuminuria were associated with both LVHBSA and LVHheight(2.7). Increased waist circumference was the strongest independent predictor of LVHheight(2.7), but was not associated with LVHBSA. We found a significant interaction between abdominal obesity and systolic BP24h in LVHheight(2.7). Concentric remodelling seems to be the most prevalent alteration of left ventricular geometry in early stages of hypertension (37.5%).
  
  
  CONCLUSIONS
  The impact of obesity as predictor of LVH in never treated hypertensives is present only when left ventricular mass (LVM) is indexed to height(2.7). Obesity interacts with systolic BP24h in an additive but not merely synergistic manner. Systolic BP24h is the strongest determinant of LVH when indexed for BSA.
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, Spain; Departamento de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Castellón, Spain. Electronic address: rodilla_enr@gva.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: Rodilla
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Costa
authors.affiliation: Unidad de Cardiología, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, Spain.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Martín
authors.affiliation: Servicio de Medicina Preventiva, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: González
authors.affiliation: Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, Spain; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Medicina, Universidad de Valencia, Valencia, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Pascual
authors.affiliation: Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Medicina, Universidad de Valencia, Valencia, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Redon
mesh_terms: D050153:Abdominal Fat / Q000503:physiopathology*; D000328:Adult; D000419:Albuminuria / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D001827:Body Height; D001830:Body Surface Area; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D009929:Organ Size; D015995:Prevalence; D013599:Systole; D014463:Ultrasonography; D020257:Ventricular Remodeling; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: Ambulatory blood pressure; Echocardiography; Ecocardiografía; Geometría ventricular; Hipertension; Hipertrofia ventricular izquierda; Hypertension; Left ventricular hypertrophy; Obesidad; Obesity; Presión arterial ambulatoria; Ventricular geometry