title: Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study.
abstract: OBJECTIVE
  to examine the association between subjective and objective measures of sleep and wake and other health parameters in a cohort of the very old.
  
  
  METHODS
  a population-based cohort study.
  
  
  METHODS
  primary care, North East England.
  
  
  METHODS
  four hundred and twenty-one men and women, aged 87-89, recruited to the Newcastle 85+ Study cohort.
  
  
  METHODS
  sleep questionnaires were administered and sleep-wake patterns were assessed over 5-7 days with a novel wrist triaxial accelerometer. Associations between sleep measures and various health parameters, including mortality at 24 months, were examined.
  
  
  RESULTS
  only 16% of participants perceived their sleep as severely disturbed as assessed with questionnaire responses. Wrist accelerometry showed marked variation between normal and abnormal sleep-wake cycles that did not correlate with the participants' perception of sleep. Impaired sleep-wake cycles were significantly associated with cognitive impairment, disability, depression, increased falls, body mass index and arthritis but not with any other specific disease markers and with decreased survival.
  
  
  CONCLUSIONS
  commonly used sleep questionnaires do not differentiate well between those with objectively determined disturbance of sleep-wake cycles and those with normal cycles. Abnormal sleep-wake patterns are associated with institutionalisation, cognitive impairment, disability, depression and arthritis but not with other diseases; there is also an association with reduced survival.
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
authors.forename: Kirstie N
authors.initials: KN
authors.lastname: Anderson
authors.forename: Michael
authors.initials: M
authors.lastname: Catt
authors.forename: Joanna
authors.initials: J
authors.lastname: Collerton
authors.forename: Karen
authors.initials: K
authors.lastname: Davies
authors.forename: Thomas
authors.initials: T
authors.lastname: von Zglinicki
authors.forename: Thomas B L
authors.initials: TB
authors.lastname: Kirkwood
authors.forename: Carol
authors.initials: C
authors.lastname: Jagger
mesh_terms: D056044:Actigraphy / Q000295:instrumentation; D000367:Age Factors; D000369:Aged, 80 and over; D001168:Arthritis / Q000453:epidemiology; D021081:Chronobiology Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D002940:Circadian Rhythm; D003072:Cognition Disorders / Q000453:epidemiology; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D004185:Disability Evaluation; D004739:England / Q000453:epidemiology; D004867:Equipment Design; D005260:Female; D006306:Health Surveys; D006801:Humans; D007326:Institutionalization; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity; D011320:Primary Health Care; D016016:Proportional Hazards Models; D012307:Risk Factors; D012890:Sleep; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014851:Wakefulness
keywords: 85+; accelerometry; circadian rhythm; impaired sleep and mortality; lder people; novel accelerometer; sleep