title: Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display.
abstract: We have developed a novel miniature integrated optical coherence tomography (OCT)-intravascular ultrasound (IVUS) probe, with a 1.5-mm-long rigid part and 0.9-mm outer diameter, for real-time intracoronary imaging of atherosclerotic plaques and guiding of interventional procedures. By placing the OCT ball lens and IVUS transducer back-to-back at the same axial position, this probe can provide automatically coregistered, coaxial OCT-IVUS imaging. To demonstrate its real-time capability, three-dimensional OCT-IVUS imaging of a pig's coronary artery displaying in polar coordinates, as well as images of three major types of atherosclerotic plaques in human cadaver coronary segments, were obtained using this probe and our upgraded system. Histology validation is also presented.
authors.affiliation: University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92612cUniversity of California, Irvine, Beckman Laser Institute, Irvine, California 92612eUniversity of California, Irvine, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, California 92617.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Li
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.forename: Joseph
authors.initials: J
authors.lastname: Jing
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Pranav M
authors.initials: PM
authors.lastname: Patel
authors.forename: K
authors.initials: K
authors.lastname: Kirk Shung
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D003331:Coronary Vessels / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008904:Miniaturization / Q000295:instrumentation*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods*