title: Hyperimmunoglobulin E syndrome-like symptoms in a hemodialysis patient who developed multiple subcutaneous Staphylococcus aureus abscesses.
abstract: Hyperimmunoglobulin E syndrome (HIES) is sporadically triggered by de novo genetic mutations of the signal transducer and activator of transcription 3 (STAT3). Dialysis patients frequently exhibit HIES-like symptoms including elevated IgE levels and recurrent bacterial infections. We herein report the case of a 74-year-old man on hemodialysis (HD) who developed marked IgE elevation and multiple subcutaneous cold Staphylococcus aureus abscesses. We are the first to report that a dialysis patient presented with HIES-like symptoms without the characteristic facies or bone and connective tissue abnormalities. A STAT3 gene analysis was conducted as part of the differential diagnosis.
authors.affiliation: Takasago Municipal Hospital, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yokota
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kanemitsu
authors.forename: Naoya
authors.initials: N
authors.lastname: Igaki
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000209:etiology; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007589:Job Syndrome / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000209:etiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*