title: Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers.
abstract: A new series of 64-valent glycodendrimers was prepared in excellent yield and purity using a divergent and iterative strategy based on oxime ligation. Enzyme-linked lectin assays revealed the first nanomolar inhibitor for the fucose-specific lectin isolated from Ulex europaeus.
authors.affiliation: Département de Chimie Moléculaire, UMR-CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France. olivier.renaudet@ujf-grenoble.fr.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Thomas
authors.forename: Nathalie
authors.initials: N
authors.lastname: Berthet
authors.forename: Julian
authors.initials: J
authors.lastname: Garcia
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D006001:Glycoconjugates; D010091:Oximes; D010456:Peptides, Cyclic