title: Efficacy of Olyset® Plus, a new long-lasting insecticidal net incorporating permethrin and piperonyl-butoxide against multi-resistant malaria vectors [corrected].
abstract: Due to the rapid extension of pyrethroid resistance in malaria vectors worldwide, manufacturers are developing new vector control tools including insecticide mixtures containing at least two active ingredients with different mode of action as part of insecticide resistance management. Olyset® Plus is a new long-lasting insecticidal net (LLIN) incorporating permethrin and a synergist, piperonyl butoxide (PBO), into its fibres in order to counteract metabolic-based pyrethroid resistance of mosquitoes. In this study, we evaluated the efficacy of Olyset® Plus both in laboratory and field against susceptible and multi-resistant malaria vectors and compared with Olyset Net, which is a permethrin incorporated into polyethylene net. In laboratory, Olyset® Plus performed better than Olyset® Net against susceptible Anopheles gambiae strain with a 2-day regeneration time owing to an improved permethrin bleeding rate with the new incorporation technology. It also performed better than Olyset® Net against multiple resistant populations of An. gambiae in experimental hut trials in West Africa. Moreover, the present study showed evidence for a benefit of incorporating a synergist, PBO, with a pyrethroid insecticide into mosquito netting. These results need to be further validated in a large-scale field trial to assess the durability and acceptability of this new tool for malaria vector control.
authors.affiliation: Institut de Recherche pour le Développement (IRD), Maladies Infectieuses et Vecteurs, Ecologie, Genetique, Evolution et Controle (MIVEGEC), UM1-UM2-CNRS 5290 IRD 224, Cotonou, Bénin ; Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Bénin.
authors.forename: Cédric
authors.initials: C
authors.lastname: Pennetier
authors.forename: Aziz
authors.initials: A
authors.lastname: Bouraima
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chandre
authors.forename: Michael
authors.initials: M
authors.lastname: Piameu
authors.forename: Josiane
authors.initials: J
authors.lastname: Etang
authors.forename: Marie
authors.initials: M
authors.lastname: Rossignol
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sidick
authors.forename: Barnabas
authors.initials: B
authors.lastname: Zogo
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Lacroix
authors.forename: Rajpal
authors.initials: R
authors.lastname: Yadav
authors.forename: Olivier
authors.initials: O
authors.lastname: Pigeon
authors.forename: Vincent
authors.initials: V
authors.lastname: Corbel
mesh_terms: D000818:Animals; D000852:Anopheles; D005260:Female; D007305:Insecticide Resistance / Q000187:drug effects; D057148:Insecticide-Treated Bednets; D007306:Insecticides / Q000494:pharmacology*; D008288:Malaria / Q000517:prevention & control*; D009032:Mosquito Control / Q000379:methods*; D026023:Permethrin / Q000494:pharmacology*; D010882:Piperonyl Butoxide / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D026023:Permethrin; D010882:Piperonyl Butoxide