title: Reduced subicular subdivisions of the hippocampal formation and verbal declarative memory impairments in young relatives at risk for schizophrenia.
abstract: BACKGROUND
  Smaller hippocampal volumes similar to those found in schizophrenia (SZ) are frequently observed to a lesser extent in non-psychotic first-degree relatives of patients with the illness, compared to control subjects. In this study, subdivisions of the hippocampal formation and their association with verbal and visual learning and memory were assessed in persons at familial high risk (FHR) for SZ.
  
  
  METHODS
  MRI scans were acquired using a 3T Siemens scanner of young adult (ages 19-32) FHR subjects (N=46) and controls with no family history of illness (i.e., at low genetic risk LRC; N=31) were processed using FreeSurfer 5.0. Subfields of the hippocampal formation were evaluated using the van Leemput method (Van Leemput et al., 2010). Learning and memory measures were collected by standardized neurocognitive tests.
  
  
  RESULTS
  Controlling intracranial volume, significantly reduced left (p<0.025), and right hippocampus (p<0.024) volumes were observed in FHR subjects. Among the subfields, the left (p<0.01) and right subicula (p<0.005) were significantly reduced in the FHR group. Immediate verbal recall of stories was significantly impaired and was significantly correlated with the left and right subicula within the FHR group.
  
  
  CONCLUSIONS
  Reduced subiculum volume and its association with verbal memory refines further the association with left and right hippocampus reported in previous FHR studies of schizophrenia. Further research is needed to determine the specific genetic and environmental risk factors that may be related to hippocampal subfield alterations.
authors.affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; MGH/MIT/HMS Martinos Center for Biomedical Imaging Boston, MA, United States.
authors.forename: Alan N
authors.initials: AN
authors.lastname: Francis
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: Neeraj
authors.initials: N
authors.lastname: Tandon
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
authors.forename: Heidi W
authors.initials: HW
authors.lastname: Thermenos
authors.forename: Raquelle I
authors.initials: RI
authors.lastname: Mesholam-Gately
authors.forename: Ludger T
authors.initials: LT
authors.lastname: van Elst
authors.forename: Brunna
authors.initials: B
authors.lastname: Tuschen-Caffier
authors.forename: Lynn E
authors.initials: LE
authors.lastname: DeLisi
authors.forename: Matcheri S
authors.initials: MS
authors.lastname: Keshavan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult