title: Shape design of high drug payload nanoparticles for more effective cancer therapy.
abstract: We developed different-shaped drug nanocrystals with similar hydrodynamic sizes and surface charges, and found that nanorods exhibited much higher in vitro and in vivo anticancer efficacy than that of nanospheres.
authors.affiliation: Functional Nano & Soft Materials Laboratory (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China. xjzhang@suda.edu.cn jsjie@suda.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Hao
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Jie
authors.forename: Baishun
authors.initials: B
authors.lastname: Tian
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D002166:Camptothecin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D006207:Half-Life; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D014183:Transplantation, Heterologous
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011092:Polyethylene Glycols; D002166:Camptothecin