title: A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome.
abstract: This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.
authors.affiliation: a Waisman Center , University of Wisconsin-Madison , Madison , Wisconsin.
authors.forename: Sara T
authors.initials: ST
authors.lastname: Kover
authors.forename: Elizabeth I
authors.initials: EI
authors.lastname: Pierpont
authors.forename: Jee-Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: W Ted
authors.initials: WT
authors.lastname: Brown
authors.forename: Leonard
authors.initials: L
authors.lastname: Abbeduto
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000235:genetics*; D003071:Cognition; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007361:Intelligence Tests; D008137:Longitudinal Studies; D008297:Male; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009483:Neuropsychological Tests; D010641:Phenotype; D012720:Severity of Illness Index; D012959:Socioeconomic Factors
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins