title: Bioinspired greigite magnetic nanocrystals: chemical synthesis and biomedicine applications.
abstract: Large scale greigite with uniform dimensions has stimulated significant demands for applications such as hyperthermia, photovoltaics, medicine and cell separation, etc. However, the inhomogeneity and hydrophobicity for most of the as prepared greigite crystals has limited their applications in biomedicine. Herein, we report a green chemical method utilizing β-cyclodextrin (β-CD) and polyethylene glycol (PEG) to synthesize bioinspired greigite (Fe₃S₄) magnetic nanocrystals (GMNCs) with similar structure and magnetic property of magnetosome in a large scale. β-CD and PEG is responsible to control the crystal phase and morphology, as well as to bound onto the surface of nanocrystals and form polymer layers. The GMNCs exhibit a transverse relaxivity of 94.8 mM⁻¹ s⁻¹ which is as high as iron oxide nanocrystals, and an entrapment efficiency of 58.7% for magnetic guided delivery of chemotherapeutic drug doxorubicin. Moreover, enhanced chemotherapeutic treatment of mice tumor was obtained via intravenous injection of doxorubicin loaded GMNCs.
authors.affiliation: 1] Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, Department of Materials Science and Engineering, Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China [2].
authors.forename: Mei
authors.initials: M
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Xu
authors.forename: Huai-Ling
authors.initials: HL
authors.lastname: Gao
authors.forename: Liang
authors.initials: L
authors.lastname: Dong
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Xu
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Yu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D007501:Iron / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D013440:Sulfides; D047392:beta-Cyclodextrins; C111959:greigite; D011092:Polyethylene Glycols; D007501:Iron; C031215:betadex