title: Early predictors of gestational hypertension in a low-risk cohort. Results of a pilot study.
abstract: OBJECTIVE
  To determine if the clinical or biochemical markers used in pregnancy can be applied as early predictors of gestational hypertension.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  315 pregnant women referred from the Prenatal Diagnosis Unit between weeks 10-13 of pregnancy and followed up to the childbirth.
  
  
  METHODS
  Biomarkers were measured in serum specimens in the first and second trimester of pregnancy. Blood pressure (BP) was measured in the first, second and third trimester.
  
  
  RESULTS
  The cumulative incidence of gestational hypertension was 6.01%. In the first trimester gestational hypertension predictors were uric acid greater than 3.15 mg/dl (P=0.01), BMI greater than 24 kg/m (P=0.003) SBP at least 120 mmHg (P=0.02) and DBP at least 71 mmHg (P=0.007). After applied multivariate analysis just uric acid and SBP were statistically significant.
  
  
  CONCLUSIONS
  In our cohort of healthy pregnant women uric acid above 3.15 mg/dl and SBP at least 120 mmHg are consistent predictors of gestational hypertension in the first trimester. The most important implication of our study is the possibility to identify in the first trimester women at risk to develop gestational hypertension using available markers.
authors.affiliation: aHypertension Unit. Hospital Clínico San Carlos bDepartment of Clinical Chemistry cDepartment of Epidemiology and Preventive Medicine dDepartment of Gynecology and Obstetrics, Hospital Clínico San Carlos. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Martell-Claros
authors.forename: Fiona
authors.initials: F
authors.lastname: Blanco-Kelly
authors.forename: María
authors.initials: M
authors.lastname: Abad-Cardiel
authors.forename: María J
authors.initials: MJ
authors.lastname: Torrejón
authors.forename: Beatriz
authors.initials: B
authors.lastname: Alvarez-Alvarez
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Fuentes
authors.forename: Dolores
authors.initials: D
authors.lastname: Ortega
authors.forename: Manuel
authors.initials: M
authors.lastname: Arroyo
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Herraiz
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D010865:Pilot Projects; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers