title: Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil.
abstract: Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis (TB). Both infections are highly endemic in Brazil. The aim of this study was to assess the prevalence of HTLV-1/2 in TB patients in Central-West Brazil and to perform a genetic characterisation of the respective isolates. Of the 402 patients, six (1.49%) were positive for anti-HTLV and five (1.24%; 95% confidence interval: 0.46-3.05) were infected with HTLV-1/2. Genetic characterisation demonstrated that the four HTLV-1 isolates belonged to the Transcontinental subgroup A of the Cosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c). The prevalence of HTLV infection observed in this study is higher than that observed in local blood donors and the HTLV-1 and 2 subtypes identified are consistent with those circulating in Brazil.
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública.
authors.forename: Aline Garcia
authors.initials: AG
authors.lastname: Kozlowski
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública.
authors.forename: Megmar Aparecida dos Santos
authors.initials: MA
authors.lastname: Carneiro
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública.
authors.forename: Márcia Alves Dias de
authors.initials: MA
authors.lastname: Matos
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Goiás, GoiâniaGO, Brasil.
authors.forename: Sheila Araújo
authors.initials: SA
authors.lastname: Teles
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública.
authors.forename: João Alves Filho
authors.initials: JA
authors.lastname: Araújo
authors.affiliation: Instituto Oswaldo Cruz, Rio de JaneiroRJ, Brasil.
authors.forename: Koko
authors.initials: K
authors.lastname: Otsuki
authors.affiliation: Instituto Oswaldo Cruz, Rio de JaneiroRJ, Brasil.
authors.forename: Ana Carolina Paulo
authors.initials: AC
authors.lastname: Vicente
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública.
authors.forename: Regina Maria Bringel
authors.initials: RM
authors.lastname: Martins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000382:microbiology; D017977:Deltaretrovirus / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D015490:HTLV-I Infections / Q000150:complications / Q000453:epidemiology*; D015491:HTLV-II Infections / Q000150:complications / Q000453:epidemiology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral