title: RET fusion genes in Korean non-small cell lung cancer.
abstract: Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Yoo
authors.forename: Guang
authors.initials: G
authors.lastname: Jin
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Jung
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Hong
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Shin Yup
authors.initials: SY
authors.lastname: Lee
authors.forename: Jeong Ok
authors.initials: JO
authors.lastname: Lim
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D003598:Cytoskeletal Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D016547:Kinesins / Q000235:genetics; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D017422:Sequence Analysis, DNA
chemical_list: C088832:CCDC6 protein, human; D003598:Cytoskeletal Proteins; C488101:KIF5B protein, human; D015514:Oncogene Proteins, Fusion; D051096:Proto-Oncogene Proteins c-ret; D016547:Kinesins
keywords: CCDC6; Carcinoma, Non-Small-Cell Lung; KIF5B; Korean; RET Fusion