title: Going with the flow: from circulating tumor cells to DNA.
abstract: Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Francois-Clement
authors.initials: FC
authors.lastname: Bidard
authors.forename: Britta
authors.initials: B
authors.lastname: Weigelt
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Reis-Filho
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics; D006801:Humans; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D017354:Point Mutation / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm