title: Biopsy and radical prostatectomy pathological patterns influence Prostate cancer gene 3 (PCA3) score.
abstract: OBJECTIVE
  To evaluate the relationship between Prostate cancer gene 3 (PCA3) score and prostate cancer as assessed by Gleason Score (GS) and pathological stage in a series of Italian patients, with elevated Prostate specific antigen (PSA) undergoing radical prostatectomy (RP).
  
  
  METHODS
  A total of 222 patients underwent RP for clinically localized prostate cancer; total PSA, free-PSA (%fPSA) and PCA3 score were collected and the possible associations among PCA3 and histological grade/pathological stage at biopsy and RP were investigated.
  
  
  RESULTS
  Median PCA3 scores by GS at radical prostatectomy were 51 vs. 67 (GS <7 vs. GS ≥ 7, p=0.007), while scores at the biopsy were 56 vs. 67 (GS <7 vs. GS ≥ 7, p=0.007), and in pT2 vs. pT3 patients they were 54 vs. 80 (p=0.001). Positive digital rectal examination (DRE) (odds ratio (OR)=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3 ≥ 35 (OR=2.04, p=0.030) were the main risk factors for the presence of an aggressive disease (GS ≥ 7 at RP).
  
  
  CONCLUSIONS
  PCA3 score could play an interesting role in predicting significant disease: positive DRE (OR=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3 ≥ 35 (OR=2.04, p=0.030) were the main independent risk factors for GS ≥ 7 at RP.
authors.affiliation: Division of Urology, Ospedale Gradenigo, Corso Regina Margherita 8, 10153, Torino, Italy. delucastefano@yahoo.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: De Luca
authors.forename: Roberto
authors.initials: R
authors.lastname: Passera
authors.forename: Enrico
authors.initials: E
authors.lastname: Bollito
authors.forename: Angela
authors.initials: A
authors.lastname: Milillo
authors.forename: Roberto Mario
authors.initials: RM
authors.lastname: Scarpa
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
authors.forename: Renato
authors.initials: R
authors.lastname: Coda
authors.forename: Donato Franco
authors.initials: DF
authors.lastname: Randone
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics / Q000652:urine*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000652:urine*; D001706:Biopsy; D006801:Humans; D007610:Kallikreins / Q000235:genetics / Q000652:urine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000235:genetics / Q000652:urine; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery / Q000652:urine*; D012333:RNA, Messenger / Q000652:urine*; D012372:ROC Curve
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C479341:prostate cancer antigen 3, human; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Gleason Score; PCA3; Prostate cancer; radical prostatectomy