title: Clinical and echocardiographic characteristics associated with the evolution of the ductus arteriosus in the neonate with birth weight lower than 1,500g.
abstract: OBJECTIVE
  To identify clinical and echocardiographic parameters associated with the evolution of the ductus arteriosus in neonates with birth weight lower than 1,500g.
  
  
  METHODS
  Retrospective study of 119 neonates in which clinical parameters (Prenatal: maternal age, risk of infection and chorioamnionitis, use of corticosteroid, mode of delivery and gestational age. Perinatal: weight, Apgar score, gender and birth weight/gestational age classification; Postnatal: use of surfactant, sepsis, fluid intake, heart murmur, heart rate, precordial movement and pulses, use of diuretics, oxygenation index, desaturation/apnea, ventilatory support, food intolerance, chest radiography, renal function, hemodynamic instability, and metabolic changes) and echocardiographic parameters (ductus arteriosus diameter, ductus arteriosus/weight ratio, left atrium/ aorta ratio, left ventricular diastolic diameter, and transductal flow direction, pattern and velocity) were analyzed. The clinical and echocardiographic parameters analyzed were considered statistically significant when p<0.05.
  
  
  RESULTS
  In the 119 neonates, the incidence of patent ductus arteriosus was 61.3%; 56 received treatment (46 pharmacological and 10 surgical treatment), 11 had spontaneous closure, 4 died, and 2 were discharged with patent ductus arteriosus. A higher incidence of chorioamnionitis, use of surfactant, lower weight and gestational age, sepsis, heart murmur, ventilatory support and worse oxygenation indices were observed in the neonates receiving treatment. The group with spontaneous closure had a smaller ductus arteriosus diameter, lower ductus arteriosus/weight ratio, and higher transductal flow velocity.
  
  
  CONCLUSIONS
  Based on clinical and echocardiographic parameters, the neonates with spontaneous closure of the ductus arteriosus could be differentiated from those who required treatment.
authors.forename: Luiza Fortunato
authors.initials: LF
authors.lastname: Visconti
authors.forename: Samira Saady
authors.initials: SS
authors.lastname: Morhy
authors.forename: Alice D'Agostini
authors.initials: AD
authors.lastname: Deutsch
authors.forename: Gláucia Maria Penha
authors.initials: GM
authors.lastname: Tavares
authors.forename: Tatiana Jardim Mussi
authors.initials: TJ
authors.lastname: Wilberg
authors.forename: Felipe de Souza
authors.initials: Fde S
authors.lastname: Rossi
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality*; D004452:Echocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008137:Longitudinal Studies; D008297:Male; D011663:Pulmonary Surfactants / Q000008:administration & dosage; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D011663:Pulmonary Surfactants