title: The stromal compartments in pancreatic cancer: are there any therapeutic targets?
abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant stromal response also known as a desmoplastic reaction. Pancreatic Stellate Cells have been identified as playing a key role in pancreatic cancer desmoplasia. There is accumulating evidence that the stroma contributes to tumour progression and to the low therapeutic response of PDAC patients. In this review we described the main actors of the desmoplastic reaction within PDAC and novel therapeutic approaches that are being tested to block the detrimental function of the stroma.
authors.affiliation: Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Churchill Hospital, RRI, Oxford OX3 7LJ, UK.
authors.forename: Serena
authors.initials: S
authors.lastname: Lunardi
authors.affiliation: Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Churchill Hospital, RRI, Oxford OX3 7LJ, UK.
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: Muschel
authors.affiliation: Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Churchill Hospital, RRI, Oxford OX3 7LJ, UK; Department of Radiation Oncology, University Hospitals Freiburg, Robert-Koch-Straße 3, 79106 Freiburg, Germany. Electronic address: tbbrunner@gmail.com.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Brunner
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002451:Cell Compartmentation / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D017154:Stromal Cells / Q000187:drug effects; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents
keywords: COX-2; CTLs; Cytotoxic T Lymphocytes; DCs; ECM; EGF; FAK; FAP-α; FGF; HSCs; IGF-1; Insulin Growth Factor-1; MDSCs; MMP; PCCs; PDAC; PDGF; PSCs; Pancreatic Stellate Cells; Pancreatic cancer; SERBIPINE2; SHH; SPARC; Stroma; TAMs; TGF-β; TIMP; Tregs; Tumour microenvironment; VEGF; cyclooxygenase-2; dendritic cells; epidermal growth factor; extracellular matrix; fibroblast activation protein-α; fibroblast growth factor; focal adhesion kinase; hepatic stellate cell; matrix metalloproteinases; myeloid-derived suppressor cells; pancreatic cancer cells; pancreatic ductal adenocarcinoma; platelet-derived growth factor; regulatory T cells (Tregs); secreted protein acidic and rich in cysteine; serine protease inhibitor nexin 2; sonic hedgehog; tPA; tissue inhibitors of metalloproteinases; tissue plasminogen activator; transforming growth factor-β; tumour associated macrophages; uPA; urokinase-type plasminogen activator; vascular endothelial growth factor; α-SMA; α-smooth muscle actin