title: 40 Hz auditory steady state response to linguistic features of stimuli during auditory hallucinations.
abstract: The auditory steady state response (ASSR) may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates (≤40 Hz) emanate mostly from central structures of the brain, and responses from high rates (≥80 Hz) emanate mostly from the peripheral auditory nerve or brainstem structures. Besides, it was reported that the gamma band ASSR (30-90 Hz) played an important role in working memory, speech understanding and recognition. This paper investigated the 40 Hz ASSR evoked by modulated speech and reversed speech. The speech was Chinese phrase voice, and the noise-like reversed speech was obtained by temporally reversing the speech. Both auditory stimuli were modulated with a frequency of 40 Hz. Ten healthy subjects and 5 patients with hallucination symptom participated in the experiment. Results showed reduction in left auditory cortex response when healthy subjects listened to the reversed speech compared with the speech. In contrast, when the patients who experienced auditory hallucinations listened to the reversed speech, the auditory cortex of left hemispheric responded more actively. The ASSR results were consistent with the behavior results of patients. Therefore, the gamma band ASSR is expected to be helpful for rapid and objective diagnosis of hallucination in clinic.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.|Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ying
authors.affiliation: Institute of Information Engineering & Technology, Huaqiao University, Xiamen, 362021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China. gxr-dea@tsinghua.edu.cn.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Gao
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000465:Algorithms; D001303:Auditory Cortex / Q000503:physiopathology*; D001307:Auditory Perception / Q000502:physiology; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008037:Linguistics; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D013060:Speech; D055815:Young Adult