title: Recent developments in microfluidic chip-based separation devices coupled to MS for bioanalysis.
abstract: In recent years, the development of microfluidic chip separation devices coupled to MS has dramatically increased for high-throughput bioanalysis. In this review, advances in different types of microfluidic chip separation devices, such as electrophoresis- and LC-based microchips, as well as 2D design of microfluidic chip-based separation devices will be discussed. In addition, the utilization of chip-based separation devices coupled to MS for analyzing peptides/proteins, glycans, drug metabolites and biomarkers for various bioanalytical applications will be evaluated.
authors.affiliation: Department of Chemistry, Soochow University, No. 70, Linhsi Road, Shihlin, 11102 Taipei, Taiwan.
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Lin
authors.forename: Tzuen-Yeuan
authors.initials: TY
authors.lastname: Lin
authors.forename: Ming-Ren
authors.initials: MR
authors.lastname: Fuh
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D015507:Drugs, Investigational / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods; D011134:Polysaccharides / Q000302:isolation & purification*; D011506:Proteins / Q000302:isolation & purification*
chemical_list: D015507:Drugs, Investigational; D011134:Polysaccharides; D011506:Proteins