title: The many lives of CTIP2: from AIDS to cancer and cardiac hypertrophy.
abstract: CTIP2 is a key transcriptional regulator involved in numerous physiological functions. Initial works have shown the importance of CTIP2 in the establishment and persistence of HIV latency in microglial cells, the main latent/quiescent viral reservoir in the brain. Recent studies have highlighted the importance of CTIP2 in several other pathologies, such as cardiac hypertrophy and various types of human malignancies. Targeting CTIP2 may therefore constitute a new approach in the treatment of these pathologies.
authors.affiliation: Institut de Parasitologie et de Pathologie Tropicale, EA7292, Université de Strasbourg, Strasbourg, France; IUT de Schiltigheim, 1 Allée d'Athènes, Schiltigheim, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Le Douce
authors.forename: Thomas
authors.initials: T
authors.lastname: Cherrier
authors.forename: Raphael
authors.initials: R
authors.lastname: Riclet
authors.forename: Olivier
authors.initials: O
authors.lastname: Rohr
authors.forename: Christian
authors.initials: C
authors.lastname: Schwartz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D006332:Cardiomegaly / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C479740:BCL11B protein, human; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins