title: Carboplatin versus alternating carboplatin and doxorubicin for the adjuvant treatment of canine appendicular osteosarcoma: a randomized, phase III trial.
abstract: Despite numerous published studies describing adjuvant chemotherapy for canine appendicular osteosarcoma, there is no consensus as to the optimal chemotherapy protocol. The purpose of this study was to determine whether either of two protocols would be associated with longer disease-free interval (DFI) in dogs with appendicular osteosarcoma following amputation. Dogs with histologically confirmed appendicular osteosarcoma that were free of gross metastases and underwent amputation were eligible for enrollment. Dogs were randomized to receive either six doses of carboplatin or three doses each of carboplatin and doxorubicin on an alternating schedule. Fifty dogs were included. Dogs receiving carboplatin alone had a significantly longer DFI (425 versus 135 days) than dogs receiving alternating carboplatin and doxorubicin (P = 0.04). Toxicity was similar between groups. These results suggest that six doses of carboplatin may be associated superior DFI when compared to six total doses of carboplatin and doxorubicin.
authors.affiliation: Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Skorupski
authors.affiliation: Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Uhl
authors.affiliation: Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Szivek
authors.affiliation: Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Allstadt Frazier
authors.affiliation: Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Rebhun
authors.affiliation: Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA.
authors.forename: C O
authors.initials: CO
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D012516:Osteosarcoma / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D016190:Carboplatin
keywords: amputation; bone tumour; canine; chemotherapy; clinical trial