title: Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.
abstract: Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Lemon
authors.forename: Peter N
authors.initials: PN
authors.lastname: Curtin
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Somers
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Greytak
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Lanning
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Jain
authors.forename: Moungi G
authors.initials: MG
authors.lastname: Bawendi
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Nocera
mesh_terms: D000818:Animals; D001897:Boronic Acids / Q000032:analysis; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry; D005947:Glucose / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010100:Oxygen / Q000032:analysis* / Q000737:chemistry*; D040081:Protein Array Analysis; D045663:Quantum Dots
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D005947:Glucose; D010100:Oxygen