title: Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: a prospective controlled study.
abstract: BACKGROUND
  SAHA syndrome is characterized by the tetrad: seborrhea, acne, hirsutism, and androgenetic alopecia. No previous study has examined the prevalence of glucose abnormalities in ovarian SAHA and explored whether it may be an independent risk factor for glucose abnormalities.
  
  
  OBJECTIVE
  In a prospective controlled study, we investigated the spectrum of glucose abnormalities in ovarian SAHA and explored whether it is associated with a more insulin-resistant profile.
  
  
  METHODS
  In all, 316 patients with a diagnosis of polycystic ovary syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were examined and underwent a 2-hour oral glucose tolerance test. Serum glucose homeostasis parameters, hormones, and adipokines were determined.
  
  
  RESULTS
  SAHA prevalence was 17.7% in patients with PCOS and predominance of the severe PCOS phenotype. Ovarian SAHA was independently associated with a more insulin-resistant profile (higher homeostatic model assessment of insulin resistance score, lower quantitative insulin sensitivity check index [QUICKI] and MATSUDA indices, and relative hypoadiponectinemia), and represented an independent risk factor for glucose abnormalities regardless of anthropometric features, age, and PCOS phenotype.
  
  
  CONCLUSIONS
  There was no performance of skin biopsies.
  
  
  CONCLUSIONS
  The prompt recognition of SAHA syndrome in women with PCOS permits an earlier diagnosis and surveillance of metabolic abnormalities, especially in Mediterranean PCOS population exhibiting a lower prevalence of glucose abnormalities.
authors.affiliation: Department of Clinical Biochemistry, University of Athens Medical School, Attikon General University Hospital, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Dalamaga
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadavid
authors.forename: Georgios
authors.initials: G
authors.lastname: Basios
authors.forename: Vassilios
authors.initials: V
authors.lastname: Vaggopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Rigopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kassanos
authors.forename: Eftihios
authors.initials: E
authors.lastname: Trakakis
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000150:complications* / Q000378:metabolism*; D012628:Dermatitis, Seborrheic / Q000150:complications* / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006628:Hirsutism / Q000150:complications* / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D010049:Ovarian Diseases / Q000150:complications* / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*; D011446:Prospective Studies; D012307:Risk Factors; D013577:Syndrome; D055815:Young Adult
chemical_list: D005947:Glucose
keywords: BMI; HA; HOMA-IR; IGF; IR; OA; OGTT; PCO; PCOS; QUICKI; SAHA; SAHA syndrome; SHBG; acne; adiponectin; androgenetic alopecia; body mass index; hirsutism; homeostatic model assessment of insulin resistance; hyperandrogenemia; insulin resistance; insulin-like growth factor; oligoanovulation; oral glucose tolerance test; polycystic ovarian morphology; polycystic ovary syndrome; quantitative insulin sensitivity check index; seborrhea; seborrhea, acne, hirsutism, and androgenetic alopecia; sex hormone-binding globulin