title: Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program.
abstract: In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection Agency (EPA) to implement a screening program to investigate the potential of pesticide chemicals and drinking water contaminants to adversely affect endocrine pathways. Consequently, the EPA launched the Endocrine Disruptor Screening Program (EDSP) to develop and validate estrogen, androgen, and thyroid (EAT) pathway screening assays and to produce standardized and harmonized test guidelines for regulatory application. In 2009, the EPA issued the first set of test orders for EDSP screening and a total of 50 pesticide actives and 2 inert ingredients have been evaluated using the battery of EDSP Tier 1 screening assays (i.e., five in vitro assays and six in vivo assays). To provide a framework for retrospective analysis of the data generated and to collect the insight of multiple stakeholders involved in the testing, more than 240 scientists from government, industry, academia, and non-profit organizations recently participated in a workshop titled "Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program." The workshop focused on the science and experience to date and was organized into three focal sessions: (a) Performance of the EDSP Tier 1 Screening Assays for Estrogen, Androgen, and Thyroid Pathways; (b) Practical Applications of Tier 1 Data; and (c) Indications and Opportunities for Future Endocrine Testing. A number of key learnings and recommendations related to future EDSP evaluations emanated from the collective sessions.
authors.affiliation: Dow AgroSciences, Indianapolis, IN, USA.
authors.forename: Daland R
authors.initials: DR
authors.lastname: Juberg
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Borghoff
authors.forename: Richard A
authors.initials: RA
authors.lastname: Becker
authors.forename: Warren
authors.initials: W
authors.lastname: Casey
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Michael P
authors.initials: MP
authors.lastname: Holsapple
authors.forename: M Sue
authors.initials: MS
authors.lastname: Marty
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Mihaich
authors.forename: Glen
authors.initials: G
authors.lastname: Van Der Kraak
authors.forename: Michael G
authors.initials: MG
authors.lastname: Wade
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Willett
authors.forename: Melvin E
authors.initials: ME
authors.lastname: Andersen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Borgert
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Coady
authors.forename: Michael L
authors.initials: ML
authors.lastname: Dourson
authors.forename: John R
authors.initials: JR
authors.lastname: Fowle
authors.forename: L Earl
authors.initials: LE
authors.lastname: Gray
authors.forename: James C
authors.initials: JC
authors.lastname: Lamb
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Ortego
authors.forename: Thaddeus T
authors.initials: TT
authors.lastname: Schug
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Toole
authors.forename: Leah M
authors.initials: LM
authors.lastname: Zorrilla
authors.forename: Oliver L
authors.initials: OL
authors.lastname: Kroner
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Patterson
authors.forename: Lori A
authors.initials: LA
authors.lastname: Rinckel
authors.forename: Brett R
authors.initials: BR
authors.lastname: Jones
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D004353:Drug Evaluation, Preclinical; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants; D018675:Toxicity Tests / Q000379:methods / Q000592:standards; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants