title: Molecular mechanism of oxidative damage of lung in mice following exposure to lanthanum chloride.
abstract: Exposure to lanthanoids (Ln) elicits an adverse response such as oxidative injury of lung in animals and human. The molecular targets of Ln remain unclear. In the present study, the function and signal pathway of nuclear factor erythroid 2 related factor 2 (Nrf2) in LaCl3 -induced oxidative stress in mouse lung were investigated. Mice were exposed to 2, 5, and 10 mg/kg body weight by nasal administration for 6 consecutive months. With increased doses, La was markedly accumulated and promoted the reactive oxygen species (ROS) production in the lung, which in turn resulted in peroxidation of lipids, proteins and DNA, and severe pulmonary damages. Furthermore, LaCl3 exposure could significantly increase levels of Nrf2, heme oxygenase 1 (HO-1) and glutamate-cysteine ligase catalytic subunit (GCLC) expressions in the LaCl3 -exposed lung. These findings imply that the induction of Nrf2 expression is an adaptive intracellular response to LaCl3 -induced oxidative stress in mouse lung, and that Nrf2 may regulate the LaCl3 -induced pulmonary damages.
authors.affiliation: Medical College of Soochow University, Suzhou, 215123, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hong
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Pan
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yu
authors.forename: Xuezi
authors.initials: X
authors.lastname: Sang
authors.forename: Lei
authors.initials: L
authors.lastname: Sheng
authors.forename: Xuecen
authors.initials: X
authors.lastname: Wang
authors.forename: Suxin
authors.initials: S
authors.lastname: Gui
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Fashui
authors.initials: F
authors.lastname: Hong
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004249:DNA Damage; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007811:Lanthanum / Q000378:metabolism / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse; D017382:Reactive Oxygen Species; C028521:lanthanum chloride; D007811:Lanthanum; D051547:Heme Oxygenase-1; D005721:Glutamate-Cysteine Ligase
keywords: Nrf2 pathway; lanthanum chloride; mice; pulmonary damage; reactive oxygen species