title: Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) fibrous mats.
abstract: This study prepared a composite scaffold composed of curcumin and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) copolymer using coelectrospinning technology. Incorporation of curcumin into the polymeric matrix had an obvious effect on the morphology and dimension of PCEC/curcumin fibers. The results of in vitro anti-oxidant tests and of the cytotoxicity assay demonstrated that the curcumin-loaded PCEC fibrous mats had significant anti-oxidant efficacy and low cytotoxicity. Curcumin could be sustainably released from the fibrous scaffolds. More importantly, in vivo efficacy in enhancing wound repair was also investigated based on a full-thickness dermal defect model for Wistar rats. The results indicated that the PCEC/curcumin fibrous mats had a significant advantage in promoting wound healing. At 21 days post-operation, the dermal defect was basically recovered to its normal condition. A percentage of wound closure reached up to 93.3 ± 5.6% compared with 76.9 ± 4.9% of the untreated control (p < 0.05). Therefore, the as-prepared PCEC/curcumin composite mats are a promising candidate for use as wound dressing.
authors.affiliation: Department of Oncology, the Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China.
authors.forename: Shao-Zhi
authors.initials: SZ
authors.lastname: Fu
authors.forename: Xiao-Hang
authors.initials: XH
authors.lastname: Meng
authors.forename: Juan
authors.initials: J
authors.lastname: Fan
authors.forename: Ling-Lin
authors.initials: LL
authors.lastname: Yang
authors.forename: Qing-Lian
authors.initials: QL
authors.lastname: Wen
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Ye
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Bi-Qiong
authors.initials: BQ
authors.lastname: Wang
authors.forename: Lan-Lan
authors.initials: LL
authors.lastname: Chen
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Wu
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Fan
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000473:pathology
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D011091:Polyesters; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); D011092:Polyethylene Glycols; D003474:Curcumin
keywords: PCL-PEG-PCL; curcumin; dermal defect; fibrous mats; wound healing