title: A prospective, randomized, controlled, double-masked, multi-center clinical trial of medical adhesives for the closure of laparoscopic incisions.
abstract: OBJECTIVE
  To compare LiquiBand Surgical S (LB) (Advanced Medical Solutions Ltd, Plymouth, UK) with High Viscosity Dermabond (DB) (Ethicon Inc., Kirkland, Scotland) for the closure of laparoscopic wounds.
  
  
  METHODS
  Prospective, multicenter, randomized, controlled trial (Canadian Task Force classification I).
  
  
  METHODS
  Multiple district hospitals.
  
  
  METHODS
  A total of 433 subjects were enrolled between 2006 and 2009 at 4 investigational sites.
  
  
  METHODS
  In this study, LB, an octyl/butyl cyanoacrylate blend, and DB, an octyl-based cyanoacrylate, were compared for topical skin closure of laparoscopic port sites (www.clinicaltrials.gov; study identifier NCT00762905).
  
  
  RESULTS
  High dermal apposition and cosmesis scores resulted from the use of both adhesives along with low rates of wound dehiscence and suspected infections. Masked evaluators and patients favored DB in the healing of the incisions (98.3% DB vs 93.9% LB, p < .05) and (97.2% DB vs 89.4% LB, p < .05). However, there was no difference in the overall satisfaction of the appearance of the wounds. LB was found to be significantly (p < .05) faster (LB = 32.1 seconds; DB, 50.3 seconds) and easier to use than DB, and surgical users were significantly more satisfied with using LB for wound closure.
  
  
  CONCLUSIONS
  The results of this trial show the efficacy of LB for the closure of topical skin incisions; LB was significantly faster, easier to use, and resulted in greater user satisfaction compared with DB.
authors.affiliation: Department of Obstetrics and Gynecology, Royal Surrey County Hospital NHS Foundation Trust Guildford, Surrey, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kent
authors.affiliation: Department of Obstetrics and Gynecology, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Liversedge
authors.affiliation: Department of Surgery, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, West Yorkshire, UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Dobbins
authors.affiliation: Department of Surgery, Milton Keynes Hospital NHS Foundation Trust, Milton Keynes, Buckinghamshire, UK.
authors.forename: Douglas
authors.initials: D
authors.lastname: McWhinnie
authors.affiliation: Department of Obstetrics and Gynecology, Royal Surrey County Hospital NHS Foundation Trust Guildford, Surrey, UK. Electronic address: haiderjan@doctor.com.
authors.forename: Haider
authors.initials: H
authors.lastname: Jan
mesh_terms: D000328:Adult; D003487:Cyanoacrylates / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D013529:Surgical Wound Dehiscence / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D006113:United Kingdom; D014945:Wound Healing
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate
keywords: Dermabond; Laparoscopy; Liquiband; Randomized trial; Wound