title: Alveolar oxygen tension and angio-architecture of the distal adult lung.
abstract: The present study demonstrates the fine structure of pulmonary capillaries first injured and then undergoing growth in response to a change in the ambient alveolar oxygen tension. Breathing a high fraction of inspired oxygen (FiO2 0.75) triggers restriction by endothelial cell injury and effacement leading to segment narrowing and shortening and segment loss as demonstrated by a fall in density. Subsequently, breathing a relatively low fraction (FiO2 0.21) triggers capillary assembly (angiogenesis), which reverses the changes. The data underscore the structural reprogramming (reduction and restoration) of pulmonary capillaries in response to significant shifts in oxygen tension.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and.
authors.forename: Rosemary C
authors.initials: RC
authors.lastname: Jones
authors.forename: Diane E
authors.initials: DE
authors.lastname: Capen
mesh_terms: D000367:Age Factors; D000818:Animals; D002196:Capillaries / Q000293:injuries / Q000378:metabolism / Q000503:physiopathology / Q000648:ultrastructure*; D049109:Cell Proliferation; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000378:metabolism / Q000648:ultrastructure; D049452:Green Fluorescent Proteins / Q000096:biosynthesis; D006801:Humans; D018496:Hyperoxia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic; D010100:Oxygen / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000098:blood supply*; D012038:Regeneration; D013997:Time Factors; D057772:Vascular System Injuries / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
chemical_list: D049452:Green Fluorescent Proteins; D010100:Oxygen