title: Genetic variability and evolution of broad bean wilt virus 1: role of recombination, selection and gene flow.
abstract: Analysis of four genomic regions from 37 geographically diverse isolates of broad bean wilt virus 1 (BBWV-1) showed high genetic diversity in comparison to most plant viruses. Comparison of synonymous and nonsynonymous substitutions of the small coat protein gene (SCP) revealed negative selection for most amino acid positions. Phylogenetic analysis of SCP showed that some BBWV-1 isolates from distant geographical areas were genetically close, suggesting long-distance migration. Analysis of genetic differentiation revealed high gene flow between Spanish and Near Eastern subpopulations, which were separated from North-Central and South-Eastern European subpopulations. Finally, putative recombinant and reassortant genomes were also identified.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Ferriol
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Ferrer
authors.forename: Marisol
authors.initials: M
authors.lastname: Luis-Arteaga
authors.forename: José
authors.initials: J
authors.lastname: Guerri
authors.forename: Pedro
authors.initials: P
authors.lastname: Moreno
authors.forename: Luis
authors.initials: L
authors.lastname: Rubio
mesh_terms: D016000:Cluster Analysis; D005060:Europe; D019143:Evolution, Molecular; D007887:Fabaceae / Q000821:virology; D019181:Fabavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D051456:Gene Flow; D014644:Genetic Variation; D008877:Middle East; D008969:Molecular Sequence Data; D058974:Phylogeography; D010935:Plant Diseases / Q000821:virology; D011995:Recombination, Genetic; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA