title: Should chitosan and tranexamic acid be combined for improved hemostasis after sinus surgery?
abstract: Chitosan, a β-1,4-linked polymer of glucosamine with lesser amounts of N-acetylglucosamine, has well-recognized hemostatic properties. Chitosan is also able to open tight cellular junctions, facilitating paracellular drug transport and delivery. Chitosan, through topical application, facilitates the systemic delivery of analgesic drugs. Theoretically this ability could be used to enhance the local delivery of hemostatic drugs, such as tranexamic acid, improving chitosan's role as a topical dressing. Individually a chitosan-dextran gel and tranexamic acid have been shown to improve hemostasis after endoscopic sinus surgery. A combination of both should lead to improved hemostasis and better postsurgical outcomes. The use of a chitosan/tranexamic acid dressing could have a wide range of potential beneficial applications in a number of other clinical surgical settings. While the initial main application might be as an improved external hemostatic dressing, it should also be useful on a range of internal surgical wounds.
authors.affiliation: Department of Surgery, University of Auckland, New Zealand. Electronic address: jbartley@ihug.co.nz.
authors.forename: Jim
authors.initials: J
authors.lastname: Bartley
mesh_terms: D000287:Administration, Topical; D048271:Chitosan / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D010256:Paranasal Sinuses / Q000601:surgery*; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D014148:Tranexamic Acid; D048271:Chitosan