title: Effect of long-term simulated weightlessness on surfactant and water balance in mouse lungs.
abstract: Weightlessness produces adaptive and maladaptive changes in the respiratory system. We assessed the effects of 30-day antiorthostatic hanging as a model of microgravity on the water balance in the lungs and surface activity and phospholipid composition of pulmonary surfactant in C57Bl/6 mice. Long-term antiorthostatic hanging increased water content in the lungs and reduced surface-active properties of the surfactant. This was accompanied by an increase in the content of alveolar phospholipids and changes in their fractional composition (increase in the relative content of lysophosphatidylcholine and phosphatidylethanolamine).
authors.affiliation: Izhevsk State Medical Academy, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Scences, Moscow, Russia. bryndina@udm.net.
authors.forename: I G
authors.initials: IG
authors.lastname: Bryndina
authors.forename: N N
authors.initials: NN
authors.lastname: Vasilieva
authors.forename: Yu A
authors.initials: YA
authors.lastname: Krivonogova
authors.forename: V M
authors.initials: VM
authors.lastname: Baranov
mesh_terms: D000818:Animals; D003720:Densitometry; D008168:Lung / Q000737:chemistry*; D008244:Lysophosphatidylcholines / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D010714:Phosphatidylethanolamines / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011650:Pulmonary Alveoli / Q000737:chemistry; D011663:Pulmonary Surfactants / Q000032:analysis*; D018709:Statistics, Nonparametric; D014867:Water / Q000032:analysis*; D014893:Weightlessness
chemical_list: D008244:Lysophosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D011663:Pulmonary Surfactants; D014867:Water; C483858:phosphatidylethanolamine