title: The roles of TGFβ in the tumour microenvironment.
abstract: The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.
authors.affiliation: Vanderbilt University Medical Center, Vanderbilt-Ingram Comprehensive Cancer Center, Medicine and Pathology, Cancer Biology, 2220 Pierce Avenue, 691 Preston Research Building, Nashville, Tennessee 37232, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Pickup
authors.forename: Sergey
authors.initials: S
authors.lastname: Novitskiy
authors.forename: Harold L
authors.initials: HL
authors.lastname: Moses
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002465:Cell Movement; D018450:Disease Progression; D044127:Epigenesis, Genetic; D005347:Fibroblasts / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D010641:Phenotype; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D016212:Transforming Growth Factor beta