title: Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics.
abstract: Optimization of [(18)F]radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a conventional reaction vessel is reported. [(18)F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleophiles, H-bond donors, and water was also assessed and demonstrated the versatility and potential utility of [(18)F]sulfonyl fluorides as synthons for indirect radiolabeling.
authors.affiliation: LifeSciences Division, Australian Nuclear Science and Technology Organisation (ANSTO) , Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.
authors.forename: Lidia
authors.initials: L
authors.lastname: Matesic
authors.forename: Naomi A
authors.initials: NA
authors.lastname: Wyatt
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Fraser
authors.forename: Maxine P
authors.initials: MP
authors.lastname: Roberts
authors.forename: Tien Q
authors.initials: TQ
authors.lastname: Pham
authors.forename: Ivan
authors.initials: I
authors.lastname: Greguric
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000097:blood / Q000138:chemical synthesis / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D015394:Molecular Structure; D011854:Radiochemistry / Q000295:instrumentation; D051381:Rats; D013441:Sulfinic Acids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; D013441:Sulfinic Acids; C048899:sulfuryl fluoride