title: Experimental substantiation for the use of mexidol and 3-hydroxypyridine fumarate in chronic myocardial injury.
abstract: We studied the cardioprotective properties of mexidol and 3-hydroxypyridine fumarate in rat model of chronic myocardial injury. We found that 3-hydroxypyridine fumarate (25 mg/kg) produced more pronounced antioxidant and cardioprotective effects than mexidol (25 mg/kg).
authors.affiliation: Department of Pharmacology, Department of Normal Anatomy, N. P. Ogarev Mordovia State University, Saransk, Russia. drozdov-i1ya@mail.ru.
authors.forename: M N
authors.initials: MN
authors.lastname: Zamotaeva
authors.forename: I N
authors.initials: IN
authors.lastname: Chairkin
authors.forename: V I
authors.initials: VI
authors.lastname: Inchina
authors.forename: I A
authors.initials: IA
authors.lastname: Drozdov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D004734:Energy Metabolism / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy*; D008315:Malondialdehyde / Q000097:blood; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D010847:Picolines / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000975:Antioxidants; D010847:Picolines; D010975:Platelet Aggregation Inhibitors; D011725:Pyridines; C070020:emoxypine succinate; C023500:3-hydroxypyridine; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D011188:Potassium