title: Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery.
abstract: Enhanced selectivity and efficacy is important for advanced drug delivery. Herein, a novel type of folic acid conjugated self-assembled layered double hydroxide nanoparticles is reported. These nanoparticles have a drug loading capacity of 27 wt% and are able to enter cell nuclei and dramatically improve the efficacy of MTX.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, China. xianfeng.chen@cityu.edu.hk.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Zhu
authors.forename: Longbiao
authors.initials: L
authors.lastname: Huang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhu
authors.forename: V A L
authors.initials: VA
authors.lastname: Roy
authors.forename: K N
authors.initials: KN
authors.lastname: Yu
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006878:Hydroxides / Q000737:chemistry*; D008727:Methotrexate / Q000737:chemistry / Q000633:toxicity; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D006878:Hydroxides; C031356:hydroxide ion; D005492:Folic Acid; D008727:Methotrexate