title: HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
abstract: HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively expressed, cognate protein of the HSP70 family, which is central in many cellular processes. In particular, its regulatory role in autophagy is decisive. We focused this review on HSC70 structure-function considerations and based on this, we put a particular emphasis on HSC70 targeting by small molecules and peptides in order to develop intervention strategies that deviate some of HSC70 properties for therapeutic purposes. Generating active biomolecules regulating autophagy via its effect on HSC70 can effectively be designed only if we understand the fine relationships between HSC70 structure and functions.
authors.affiliation: CNRS; Institut de Biologie Moléculaire et Cellulaire; Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis; Strasbourg, France.
authors.forename: François
authors.initials: F
authors.lastname: Stricher
authors.forename: Christophe
authors.initials: C
authors.lastname: Macri
authors.forename: Marc
authors.initials: M
authors.lastname: Ruff
authors.forename: Sylviane
authors.initials: S
authors.lastname: Muller
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001343:Autophagy; D050883:HSC70 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007109:Immunity / Q000235:genetics; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008958:Models, Molecular; D058990:Molecular Targeted Therapy; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D050883:HSC70 Heat-Shock Proteins; D007166:Immunosuppressive Agents
keywords: HSC70; P140 peptide; X-ray structure; autophagy; lupus; nucleotide exhange factor