title: Morningness-eveningness and treatment response in major depressive disorder.
abstract: In a large, prospective, 8-week open study of 721 outpatients receiving agomelatine treatment for a current major depressive episode (MDE), morningness-eveningness (Composite Scale of Morningness) was assessed before and after treatment to investigate possible changes in morningness-eveningness after treatment and evaluate whether morningness-eveningness at baseline predicted treatment response. A change towards morningness was observed after treatment. This change was greater in responders than non-responders. Moreover, being a morning type at baseline was an independent predictor of response to treatment. Once thought to be a trait variable, morningness-eveningness is a potential treatment target that should be systematically assessed in MDE patients.
authors.affiliation: Paris XI University, INSERM U 669, Department of Psychiatry, Bicêtre University Hospital , Assistance Publique - Hôpitaux de Paris, 94230 Le Kremlin Bicêtre , France .
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
authors.forename: Ellen
authors.initials: E
authors.lastname: Frank
authors.forename: Florence
authors.initials: F
authors.lastname: Gressier
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.forename: Frank
authors.initials: F
authors.lastname: Bayle
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vaiva
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000204:Activity Cycles / Q000187:drug effects; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012919:Social Behavior; D013997:Time Factors; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; C084711:agomelatine; D009281:Naphthalenes