title: Osteolytic myxopapillary ependymoma with marked hyaline degeneration in a 72-year-old male: A case report.
abstract: Myxopapillary ependymomas (MPEs) are uncommon and account for ∼15% of all ependymomas. The current study presents a case of rare spinal MPE with abnormal hyaline degeneration. The patient was a 72-year-old male with a 10-month history of lower back pain. Magnetic resonance imaging revealed a mass involving the L4 and L5 vertebrae with local bone destruction. The tumor was completely resected. Histologically, the majority of the tumor exhibited low cellularity. A marked change in hyaline was observed in the blood vessels and stroma. In specific areas, the tumor showed reticular or tubular patterning embedded in hyaline materials. The tumor cells were cuboidal to columnar in shape with strong immunostaining for glial fibrillary acidic protein and S-100. A fluorescencein situhybridization analysis for amplification of the epidermal growth factor receptor gene was negative. The results of pathological and immunohistochemical studies were consistent with the ependymal nature of neoplastic cells.
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine;
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Mohammad Shahidul
authors.initials: MS
authors.lastname: Makki
authors.forename: Qunli
authors.initials: Q
authors.lastname: Shi
keywords: hyaline degeneration; immunohistochemistry; myxopapillary ependymoma