title: Laser-interstitial thermal therapy for refractory cerebral edema from post-radiosurgery metastasis.
abstract: BACKGROUND
  Stereotactic radiosurgery is often an effective tool for the treatment of brain metastases. A complication of radiosurgical treatment for brain metastasis can be persistent cerebral edema. Treatments of this refractory cerebral edema include observation, corticosteroids, and surgical resection of the edema-inducing mass. Laser-interstitial thermal therapy is a minimally invasive technique for ablating intracranial lesions. It may provide a treatment option for metastases after radiosurgery causing refractory cerebral edema.
  
  
  METHODS
  We report the case of a 64-year-old man with lung adenocarcinoma presenting to our department with left hemiparesis. Brain magnetic resonance imaging showed an 18-mm enhancing lesion in the right external capsule with significant surrounding edema. The lesion was treated by radiosurgery. There was persistent edema after radiosurgery. The patient required continued corticosteroid therapy to maintain his ability to ambulate. He developed refractory hyperglycemia, weight gain, and bilateral proximal muscle weakness secondary to this therapy. Fourteen weeks after radiosurgery, he underwent laser-interstitial thermal therapy for lesion ablation. He was weaned off corticosteroids during 2 weeks and maintained his strength during the following month.
  
  
  CONCLUSIONS
  Laser-interstitial thermal therapy may be a treatment option for refractory cerebral edema after stereotactic radiosurgery to a metastasis. This therapy may be of particular use in deep-seated lesions refractory to corticosteroid therapy.
authors.affiliation: Department of Neurosurgery, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA; Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA. Electronic address: Andrew.Fabiano@roswellpark.org.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Fabiano
authors.affiliation: Department of Radiology, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Alberico
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000601:surgery*; D000077192:Adenocarcinoma of Lung; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy*; D016634:Radiosurgery / Q000009:adverse effects; D016896:Treatment Outcome
keywords: Edema; Laser; Metastasis; Necrosis; Radiation; Thermal