title: Memory deficits in late-onset schizophrenia.
abstract: Late-onset schizophrenia (LOS) is a controversial diagnosis, mainly characterized by more positive symptoms and less deterioration. LOS could be considered as either an extreme of typical schizophrenia (but for old age patients, and short duration of the disorder), or an independent group of patients with a specific diagnosis, with no clear evidence in favor or against any of these hypotheses. The aim of the present study is to characterize the memory cognitive profile of LOS patients without related organic factors (N=25), compared to early-onset schizophrenic patients (EOS, N=44), matched for the duration of the disorder, and healthy controls (HC, N=23), matched for the age of patients. Lifetime clinical symptoms and functioning were collected using the DIGS and the PANSS, and components of memory capacity were assessed with the Forward and Backward Digit Span Tasks, Rey Complex Figure and Verbal Fluency Tests. LOS patients were performing significantly better than EOS patients on the digit span task, Rey's complex figure at T1 score and phonemic verbal fluency. However, LOS had significantly lower performances than healthy controls on the digit span task and on both verbal fluency tests. This study provides evidence that LOS had intermediate outcome compared to EOS and controls. LOS can therefore be in line with a dimensional clinical approach of schizophrenia, whereby it presents few memory deficits and few disorganization and negative symptoms with mostly positive symptoms and possibly etiopathogenic specificities. Further studies including more specific memory assessment tests and larger samples are needed to confirm the present finding.
authors.affiliation: AP-HP, Department of Psychiatry, Fernand Widal Hospital, Paris, France.
authors.forename: Clara
authors.initials: C
authors.lastname: Brichant-Petitjean
authors.forename: Cindy
authors.initials: C
authors.lastname: Legauffre
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ramoz
authors.forename: Jean
authors.initials: J
authors.lastname: Ades
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Caroline
authors.initials: C
authors.lastname: Dubertret
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology
keywords: Cognitive deficits; Late-onset schizophrenia; Memory impairment; Neuropsychological tests