title: Catalytic, enantioselective 1,3-dipolar cycloadditions of nitrile imines with methyleneindolinones.
abstract: Catalytic, enantioselective 1,3-dipolar cycloadditions of nitrile imines with methyleneindolinones are reported. The spiro[pyrazolin-3,3'-oxindole] products are formed in good yields (up to 98%) and high enantioselectivity (up to 99% ee).
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. lstanley@iastate.edu.
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Gerten
authors.forename: Michael C
authors.initials: MC
authors.lastname: Slade
authors.forename: Kelsie M
authors.initials: KM
authors.lastname: Pugh
authors.forename: Levi M
authors.initials: LM
authors.lastname: Stanley
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007097:Imines; D007211:Indoles; D009570:Nitriles; D011720:Pyrazoles; D013141:Spiro Compounds