title: Copper-catalyzed decarboxylative trifluoromethylation of allylic bromodifluoroacetates.
abstract: The development of new synthetic fluorination reactions has important implications in medicinal, agricultural, and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluoromethyl-containing product. A two-step copper-catalyzed decarboxylative protocol for converting allylic alcohols to trifluoromethanes is reported. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ambler
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Altman
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D006845:Hydrocarbons, Fluorinated; D020005:Propanols; C006463:allyl alcohol; D003300:Copper