title: An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells.
abstract: OBJECTIVE
  To test the curative effect of human umbilical cord-derived mesenchymal stem cells on rat acute radioactive enteritis and thus to provide clinical therapeutic basis for radiation sickness.
  
  
  METHODS
  Human umbilical cord-derived mesenchymal stem cells were cultivated in vitro and the model of acute radioactive enteritis of rats was established. Then, the umbilical cord mesenchymal stem cells were injected into the rats via tail vein. Visual and histopathological changes of the experimental rats were observed.
  
  
  RESULTS
  After the injection, the rats in the prevention group and treatment group had remarkably better survival status than those in the control group. The histological observations revealed that the former also had better intestinal mucosa structure, more regenerative cells and stronger proliferation activity than the latter.
  
  
  CONCLUSIONS
  Human umbilical cord-derived mesenchymal stem cells have a definite therapeutic effect on acute radioactive enteritis in rats.
authors.affiliation: Jinan Miltary General Hospital, Shandong Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Peng
authors.initials: P
authors.lastname: Song
authors.forename: Ji
authors.initials: J
authors.lastname: Yue
authors.forename: Shi-De
authors.initials: SD
authors.lastname: Lin
authors.forename: Ting-Bao
authors.initials: TB
authors.lastname: Zhao
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004751:Enteritis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D011833:Radiation Injuries, Experimental / Q000517:prevention & control* / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D014470:Umbilical Cord / Q000166:cytology
keywords: Acute radioactive enteritis; Human umbilical cord mesenchymal stem cells; Radioactive contamination; Rat