title: Anxiolytic activity of dipeptide GB-115 after oral administration.
abstract: The anxiolytic effects of GB-115, a retroanalogue of cholecystokinin-4, administered orally to outbred and inbred animals with different level of emotionality, were studied in the open field test and elevated plus-maze test. The anxiolytic effect of talanax was observed in outbred mice (0.1-0.5 mg/kg) and in inbred BALB/c mice (0.1 and 5.0 mg/kg) in the open field test. GB-115 increased the time of entries into open arms in outbred rats (0.5-0.7 mg/kg) and in BALB/c mice (0.1 mg/kg). These data confirmed the dependence of GB-115 effect on the phenotype of emotional stress response and demonstrated a shift of anxiolytic doses of the preparation from 0.006-0.100 mg/kg in intraperitoneal administration to 0.1-5.0 mg/kg in oral treatment.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. lgkolik@mail.ru.
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
authors.forename: M A
authors.initials: MA
authors.lastname: Konstantinopolsky
authors.forename: I V
authors.initials: IV
authors.lastname: Ryibina
authors.forename: P Yu
authors.initials: PY
authors.lastname: Povarnina
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002766:Cholecystokinin / Q000031:analogs & derivatives / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy*; D013758:Tetragastrin / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D004151:Dipeptides; C520797:GB-115; D013758:Tetragastrin; D002766:Cholecystokinin