title: Imatinib-induced bone edema: case report and review of literature.
abstract: Imatinib mesylate represents a revolution in the management of patients with metastatic gastrointestinal stromal tumors (GISTs). More recently, postoperative imatinib has been shown to improve both disease-free and overall survivals in patients with a high risk of recurrence. This article presents a well-documented case of a patient with painful and reversible bone edema related to imatinib.
authors.affiliation: From aHemomed - Instituto de Oncologia e Hematologia & IEP Sao Lucas, Sao Paulo, and the bGastrointestinal Cancer Unit, Medical Oncology Department and cRadiology Department, Hospital de Câncer de Barretos, Barretos, Brazil.
authors.forename: Lucas Vieira
authors.initials: LV
authors.lastname: dos Santos
authors.forename: João Paulo
authors.initials: JP
authors.lastname: Lima
authors.forename: Kathia Cristina
authors.initials: KC
authors.lastname: Abdalla
authors.forename: Arinilda Campos
authors.initials: AC
authors.lastname: Bragagnoli
authors.forename: Florinda Almeida
authors.initials: FA
authors.lastname: Santos
authors.forename: Alexandre
authors.initials: A
authors.lastname: dos Anjos Jácome
authors.forename: Fabiano Elias
authors.initials: FE
authors.lastname: Porto
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001549:Benzamides / Q000009:adverse effects* / Q000627:therapeutic use; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology*; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D046152:Gastrointestinal Stromal Tumors / Q000150:complications / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate