title: Functional implications of the Golgi and microtubular network in gonadotropes.
abstract: In contrast to the widely accepted images of the Golgi apparatus as a cup-like shape, the Golgi in pituitary gonadotropes is organized as a spherical shape in which the outer and inner faces are cis- and trans-Golgi elements, respectively. At the center of the spherical Golgi, a pair of centrioles is situated as a microtubule-organizing center from which radiating microtubules isotropically extend toward the cell periphery. This review focuses on the significance of the characteristic organization of the Golgi and microtubule network in gonadotropes, considering the roles of microtubule-dependent membrane transport in the formation and maintenance of the Golgi structure. Because the highly symmetrical organization of the Golgi is possibly perturbed in response to experimental treatments of gonadotropes, monitoring of the Golgi structure in gonadotropes under various experimental conditions will be a novel in vivo approach to elucidate the biogenesis of the Golgi apparatus.
authors.affiliation: Department of Microscopic Anatomy and Cell Biology, Asahikawa Medical University, Asahikawa, Japan. Electronic address: tyshwata@asahikawa-med.ac.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Microscopic Anatomy and Cell Biology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Bochimoto
authors.affiliation: Division of Microscopic Anatomy and Bio-imaging, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Koga
authors.affiliation: Laboratory of Molecular Life Sciences, Department of Biotechnology, Akita Prefectural University, Akita, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hosaka
authors.affiliation: Division of Microscopic Anatomy and Bio-imaging, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ushiki
mesh_terms: D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D052681:Gonadotrophs / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*
keywords: Cellular polarity; GnRH signaling; Golgi apparatus; Gonadotrope; Microtubule-organizing center (MTOC); Pituitary