title: Isolated solitary brain metastasis as a relapse of small cell lung cancer.
abstract: The brain is one of the most common sites for the metastasis of small cell lung cancer (SCLC). The present study describes two cases of an isolated solitary brain metastasis as a relapse of SCLC, which occurred more than one year after the completion of the initial successful treatment for SCLC. The tumors were identified during a regular check-up computed tomography (CT) scan and were successfully treated. To the best of our knowledge, this is the first study to report the cases of two patients with an isolated solitary brain metastasis as a relapse of SCLC. Although extremely rare, the possibility of such recurrences should be considered, particularly in patients who have refused prophylactic cranial irradiation.
authors.affiliation: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sakurai
authors.forename: Koichi
authors.initials: K
authors.lastname: Kurishima
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Homma
authors.forename: Katsunori
authors.initials: K
authors.lastname: Kagohashi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Mio
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
keywords: isolated solitary brain metastasis; relapse; small cell lung cancer