title: Treatment of pyoderma gangrenosum with topical factor XIII.
abstract: Pyoderma gangrenosum (PG) is a severe ulcerative skin disease. Despite systemic immunosuppressive therapy, PG ulcers often progress and can develop into life-threatening conditions. In this case series, we treated 6 patients suffering from recalcitrant PG with topical coagulation factor XIII, which has been shown to exert beneficial effects on tissue regeneration and wound healing. All 6 patients showed a positive response to treatment with a marked reduction in wound size that was maintained during a 3-month follow-up period. The treatment was well tolerated with no remarkable adverse effects or complications. Topical factor XIII has potential in combination with standard immunosuppressive therapy for the treatment of PG.
authors.affiliation: Department of Dermatology, Eberhard Karls University, Liebermeisterstr. 25, 72076 Tuebingen, Germany.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Hoetzenecker
authors.forename: Emmanuella
authors.initials: E
authors.lastname: Guenova
authors.forename: Vanyo
authors.initials: V
authors.lastname: Mitev
authors.forename: Stefan
authors.initials: S
authors.lastname: Schanz
authors.forename: Anja
authors.initials: A
authors.lastname: Ulmer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Fierlbeck
mesh_terms: D000279:Administration, Cutaneous; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003029:Coagulants / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005176:Factor XIII / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D003029:Coagulants; D005176:Factor XIII; D011239:Prednisolone
keywords: factor FXIII; pyoderma gangrenosum; therapy