title: The impact of cefepime as first line therapy for neutropenic fever on Clostridium difficile rates among hematology and oncology patients.
abstract: After changing empiric treatment of febrile neutropenia from meropenem to cefepime, the effect on Clostridium difficile infection (CDI) was investigated. The change was assessed using an autoregressive model. A significant increase in CDI rates occurred following the introduction of cefepime. There may be an association between increased cefepime usage and CDI.
authors.affiliation: Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA. Electronic address: eavan@esatclear.ie.
authors.forename: Eavan G
authors.initials: EG
authors.lastname: Muldoon
authors.forename: Lauren
authors.initials: L
authors.lastname: Epstein
authors.forename: Tanya
authors.initials: T
authors.lastname: Logvinenko
authors.forename: Susan
authors.initials: S
authors.lastname: Murray
authors.forename: Shira I
authors.initials: SI
authors.lastname: Doron
authors.forename: David R
authors.initials: DR
authors.lastname: Snydman
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D016360:Clostridioides difficile / Q000187:drug effects / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000139:chemically induced / Q000453:epidemiology*; D005335:Fever of Unknown Origin / Q000188:drug therapy* / Q000209:etiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000628:therapy; D006801:Humans; D009503:Neutropenia / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime
keywords: Antimicrobial stewardship; Cefepime; Clostridium difficile; Neutropenic sepsis