title: A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.
abstract: A novel and efficient method for the preparation of antiviral nucleoside 5'-H-phosphonamidates has been developed. The oxidization of the H-phosphonamidate intermediates with iodine and sulfur afforded nucleoside 5'-phosphoramidates and 5'-thiophosphoramidates in high yields.
authors.affiliation: a Jiangxi Key Laboratory of Organic Chemistry , Jiangxi Science and Technology Normal University , Nanchang , Jiangxi , PR China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Xingjian
authors.initials: X
authors.lastname: Li
authors.forename: Shanshan
authors.initials: S
authors.lastname: Gong
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Shen
authors.forename: Liang
authors.initials: L
authors.lastname: Peng
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009946:Organothiophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D018119:Stavudine / Q000138:chemical synthesis / Q000737:chemistry; D015215:Zidovudine / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000577:Amides; D000998:Antiviral Agents; D009705:Nucleosides; D009946:Organothiophosphorus Compounds; D010756:Phosphoric Acids; D011355:Prodrugs; D011741:Pyrimidine Nucleosides; D015215:Zidovudine; C011067:phosphoramidic acid; D018119:Stavudine