title: A systematic review of current and emerging approaches in the field of larynx preservation.
abstract: Treatment options targeting laryngeal preservation include conservative surgery, concurrent chemo-radiotherapy, induction chemotherapy (IC) followed by radiotherapy (RT), and alternating chemo-radiation. The goal of this paper was to perform a systematic review of randomized clinical trials (RCTs) on current and emerging approaches in the field of larynx preservation. The search identified 36 papers of which 27 did not fall within the inclusion criteria (i.e. non-RCTs). IC followed by RT has been shown to allow laryngeal preservation in about two-thirds of pts with locally advanced laryngeal or hypopharyngeal cancer without compromising survival. IC is regarded as the landmark treatment of non-surgical larynx preservation approaches. Concomitant and alternating chemoradiotherapy treatments are also acceptable in larynx preservation.
authors.affiliation: Oncology Department, ASO Santa Croce e Carle, Italy. Electronic address: nerinadenaro@hotmail.com.
authors.forename: Nerina
authors.initials: N
authors.lastname: Denaro
authors.affiliation: Radiation Oncology, ASO Santa Croce e Carle, Italy. Electronic address: elviorussi@gmail.com.
authors.forename: Elvio Grazioso
authors.initials: EG
authors.lastname: Russi
authors.affiliation: Head and Neck Surgery Department, Centre Oscar at the Lambret, France. Electronic address: J-LEFEBVRE@o-lambret.fr.
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Lefebvre
authors.affiliation: Oncology Department, ASO Santa Croce e Carle, Italy. Electronic address: merlanomc@gmail.com.
authors.forename: Marco Carlo
authors.initials: MC
authors.lastname: Merlano
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D059248:Chemoradiotherapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D007830:Larynx / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects / Q000601:surgery; D059351:Organ Sparing Treatments / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: Concomitant chemoradiotherapy; Induction chemotherapy; Larynx conservation; Larynx preservation