title: The relationship between the phenotype of Parkinson's disease and levodopa-induced dyskinesia.
abstract: Levodopa has been demonstrated to be an effective medication for Parkinson's disease (PD), but its long-term use is complicated by the subsequent development of dyskinesias. Few studies have distinguished distinct PD subtypes associated with the occurrence of Levodopa-Induced Dyskinesia (LID). Therefore, we performed a retrospective analysis to determine if the specific phenotype of PD and other epidemiological factors are associated with the development of LID. Of 367 PD patients taking levodopa, 101 of them developed LID. Multivariate logistic regression analysis demonstrated that initial tremor-dominant manifestation was associated with a reduced risk of LID, independent of other risk factors, such as age at the onset of PD, the duration and dose of levodopa.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China.
authors.forename: Yu-Han
authors.initials: YH
authors.lastname: Zhang
authors.forename: Bei-Sha
authors.initials: BS
authors.lastname: Tang
authors.forename: Chen-Yuan
authors.initials: CY
authors.lastname: Song
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Ming-Xin
authors.initials: MX
authors.lastname: Lou
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Ren-He
authors.initials: RH
authors.lastname: Yu
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Yan
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Guo
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: Clinical phenotype; Levodopa-induced dyskinesia; Parkinson's disease