title: Hsp27 as a therapeutic target in cancers.
abstract: Heat shock protein 27 (Hsp27), induced by heat shock, environmental and pathophysiological stressors, is a multidimensional protein that acts as a protein chaperone and an antioxidant. This protein plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. This stress-activated protein is up-regulated in many cancers and is associated with poor prognosis as well as treatment resistance by protecting cells from therapeutic agent that normally induces apoptosis. This review highlights the most recent findings and role of Hsp27 in cancer and the different strategies to target and inhibit Hsp27 for clinical purposes.
authors.forename: Julie
authors.initials: J
authors.lastname: Acunzo
authors.forename: Claudia
authors.initials: C
authors.lastname: Andrieu
authors.forename: Virginie
authors.initials: V
authors.lastname: Baylot
authors.forename: Alan
authors.initials: A
authors.lastname: So
authors.affiliation: The Centre de Recherche en Cancerologie de Marseille (CRCM), UMR1068 Inserm, Institut Paoli- Calmette, Aix-Marseille Universite, 27 Boulevard Lei Roure BP30059, 13273 Marseille Cedex 9, France. palma.rocchi@inserm.fr.
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D055551:HSP27 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D018832:Molecular Chaperones; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones