title: Identification of homogeneously staining regions in leukemia patients.
abstract: Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leukemia without maturation (AML-M1), aged 23-year-old female, and the other with chronic myelogenous leukemia (CML)-blast crisis, a 28-year-old female associated with double minute chromosomes. Most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.
authors.affiliation: School of Medical Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Heydarian
authors.initials: MH
authors.lastname: Moghadam
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.forename: Mirdavood
authors.initials: M
authors.lastname: Omrani
authors.forename: Kiandokht
authors.initials: K
authors.lastname: Ghanati
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Farhikhteh
authors.initials: F
authors.lastname: Poursafavi
authors.forename: Hossein
authors.initials: H
authors.lastname: Darvish
authors.forename: Davood Zare
authors.initials: DZ
authors.lastname: Abdolahi
authors.forename: Milad
authors.initials: M
authors.lastname: Gholami
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Heidari Rostamy
authors.forename: Shamsi
authors.initials: S
authors.lastname: Safari
authors.forename: Leyla
authors.initials: L
authors.lastname: Haghnejad
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Darehgazani
authors.forename: Niloofar Safavi
authors.initials: NS
authors.lastname: Naeini
authors.forename: Mehdi Ghandehari
authors.initials: MG
authors.lastname: Motlagh
authors.forename: Davar
authors.initials: D
authors.lastname: Amani
keywords: AML; HSRs; Iran; cancer; chronic myelogenous leukemia; homogeneously staining regions dmin; incidence; leukemia; new case