title: The effect of a novel drug-eluting plastic stent on biliary stone dissolution in an ex vivo bile perfusion model.
abstract: BACKGROUND
  Temporary plastic stent insertion has been considered a safe and effective bridge therapy for difficult common bile duct (CBD) stones. Infusing chemicals to directly dissolve stones through the bile duct might also be effective. However, there are no studies on the efficacy of the combination of these 2 approaches.
  
  
  OBJECTIVE
  To investigate the efficacy of a novel ethylenediaminetetraacetic acid (EDTA) and sodium cholate-eluting plastic stent on biliary stones.
  
  
  METHODS
  Ex vivo model by using different doses of active ingredient.
  
  
  METHODS
  An ex vivo bile duct model perfused with porcine bile was created. Stents coated with degradable membranes containing various concentrations of EDTA and sodium cholate were placed in the model with CBD stones.
  
  
  METHODS
  The change in the weight of stents and stones was measured every week during perfusion until the coated membranes were completely biodegraded.
  
  
  RESULTS
  The time that the stents required to be fully degraded and the efficiency of stone dissolution were positively correlated with the percentage of EDTA and sodium cholate in the stent membrane. However, the 50% EDTA and sodium cholate stents achieved the greatest percentage of stone weight loss when the drugs were completely released.
  
  
  CONCLUSIONS
  Ex vivo study.
  
  
  CONCLUSIONS
  The EDTA and sodium cholate-eluting plastic stent effectively dissolved CBD stones and has prospect in the therapy for patients with difficult CBD stones.
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Cai
authors.affiliation: Department of Gastroenterology, Central Hospital, Songjiang District, Shanghai, China.
authors.forename: Wei Xing
authors.initials: WX
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xin Jian
authors.initials: XJ
authors.lastname: Wan
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of General Surgery, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xiao Shen
authors.initials: XS
authors.lastname: Qi
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Xing Peng
authors.initials: XP
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, First People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Lun Gen
authors.initials: LG
authors.lastname: Lu
mesh_terms: D000818:Animals; D001646:Bile; D002614:Chelating Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D054855:Drug-Eluting Stents; D004492:Edetic Acid / Q000008:administration & dosage*; D042882:Gallstones / Q000628:therapy*; D006801:Humans; D010969:Plastics; D020358:Sodium Cholate / Q000008:administration & dosage*; D013552:Swine
chemical_list: D002614:Chelating Agents; D010969:Plastics; D004492:Edetic Acid; D020358:Sodium Cholate
keywords: CBD; EDTA; PCL; PLA; UDCA; common bile duct; ethylenediaminetetraacetic acid; polycaprolactone; polylactic acid; ursodeoxycholic acid