title: Van Wyk and Grumbach syndrome: two case reports and review of the published work.
abstract: Van Wyk and Grumbach syndrome is characterized by a long-standing history of hypothyroidism, high levels of thyroid-stimulating hormone, uni- or bilateral ovarian cysts, isosexual precocity and a delayed bone age. All of the features can be reversed with treatment of the underlying hypothyroidism. Here, we describe two cases of Van Wyk and Grumbach syndrome presenting with bilateral multicystic ovaries and enlargement of the pituitary gland. One patient suffered from ovarian cyst and hypophysoma resection, the other patient promptly responded to L-thyroxine with complete regression of the ovarian cyst and other symptoms.
authors.affiliation: Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Zhang
authors.forename: Nv
authors.initials: N
authors.lastname: Geng
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Wang
authors.forename: Wenyan
authors.initials: W
authors.lastname: Tian
authors.forename: Fengxia
authors.initials: F
authors.lastname: Xue
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000188:drug therapy; D010048:Ovarian Cysts / Q000175:diagnosis*; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000601:surgery; D015175:Prolactinoma / Q000175:diagnosis* / Q000601:surgery; D011629:Puberty, Precocious / Q000175:diagnosis; D013577:Syndrome; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013972:Thyrotropin; D013974:Thyroxine
keywords: delayed bone age; enlargement of pituitary gland; enlargement of polycystic ovary; hypothyroidism; isosexual precocity