title: Respiratory manifestations of gastroesophageal reflux disease.
abstract: Gastroesophageal reflux disease (GERD) is highly associated with a range of respiratory symptoms, arising from a variety of etiologies. The following commentaries on respiratory manifestations of GERD address evidence for a role of a vagally mediated bronchoconstriction reflex in the development of asthma; the direct effects of airway obstruction on lower esophageal sphincter (LES) pressure and reflux episodes; the mechanisms by which reflux may play roles in chronic cough and airway stenosis; the limited efficacy of laparoscopic antireflux surgery (LARS) in improving GERD-related respiratory symptoms; the search for a marker for microaspiration and reflux-induced airway disease; and the potential of proton pump inhibitor (PPI) treatment for patients presenting with asthma and GERD.
authors.affiliation: Department of Medicine/Pulmonary Allergy & Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Harding
authors.affiliation: Department of Otolaryngology, Northshore Hospital, Auckland, New Zealand.
authors.forename: Jacqui E
authors.initials: JE
authors.lastname: Allen
authors.affiliation: Division of Laryngology & Professional Voice, Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Blumin
authors.affiliation: Department of Surgery, University of Washington, Seattle, Washington.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Warner
authors.affiliation: Department of Surgery, University of Washington, Seattle, Washington.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pellegrini
authors.affiliation: Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Homen's Hospital, Harvard Medical School, Cambridge, Massachusetts.
authors.forename: Walter W
authors.initials: WW
authors.lastname: Chan
mesh_terms: D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D016084:Bronchoconstriction / Q000502:physiology*; D003371:Cough / Q000209:etiology* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology; D006801:Humans
keywords: GERD; asthma; bronchoconstriction; extra-esophageal reflux