title: A case of acute generalized exanthematous pustulosis due to amoxicillin-clavulanate with multiple positivity to beta-lactam patch testing.
abstract: We present a case of acute generalized exanthematous pustolosis (AGEP) induced by amoxicillin-clavulanate. Clinical diagnosis was confirmed by symptoms presentation and  histological features (Euroscar score point compatible with definite diagnosis). Patch testing performer six months later confirmed sensitization to the culprit drug and showed positivity also to other beta-lactam antibiotics (penicillin G and cephalexin). We believe that a T cell delayed response to betalactams common ring could be involved.
authors.affiliation: . luisa.bommarito@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Bomarrito
authors.forename: G
authors.initials: G
authors.lastname: Zisa
authors.forename: G
authors.initials: G
authors.lastname: Delrosso
authors.forename: P
authors.initials: P
authors.lastname: Farinelli
authors.forename: M
authors.initials: M
authors.lastname: Galimberti
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010328:Patch Tests
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination