title: Changing the Treatment of Permanent Neonatal Diabetes Mellitus from Insulin to Glibenclamide in a 4-Month-Old Infant with KCNJ11 Activating Mutation.
abstract: Permanent neonatal diabetes mellitus (PNDM) is a rare type of diabetes and KCNJ11 gene activating mutation is one of its prevalent causes. We introduced a 4-month-old male infant with poor feeding, restlessness, tachypnea, hyperglycemia, metabolic acidosis, and ketonemia. He was discharged with insulin and after 2 months, KCNJ11 gene mutation was found and treatment was switched from subcutaneous insulin to oral glibenclamide. Now, he is 1 year old with desirable glycemic control; therefore, genetic study is recommended for KCNJ11 gene mutation in such patients because if the mutation is found, treatment can be switched from insulin to sulfonylurea.
authors.affiliation: Department of Pediatrics Endocrinology, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Homa
authors.initials: H
authors.lastname: Ilkhanipoor
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Karamizadeh
keywords: KCNJ11; permanent neonatal diabetes mellitus; sulfonylurea