title: Protective effect of ARE-inducing phenol antioxidant TS-13 in chronic inflammation.
abstract: The protective effect of partially substituted monophenol TS-13 inducing the Nrf2/Keap1/ARE signaling system was studied on the model of chronic inflammation in vivo. It was found that during simulation of inflammation in an air pouch lined with synovial-like membrane, TS-13 did not affect the exudate volume, protein content, and cell count, but significantly reduced the intensity of oxidative metabolism in leukocytes of the exudate. In rheumatoid polyarthritis induced by heterologous collagen, TS-13 reduced the severity of clinical signs of inflammation only at the early stages, but inhibited H2O2 generation by monocytes and, partially, by blood neutrophils. These results suggest that the phlogolytic effect of the redox sensitive Nrf2/Keap1/ARE signaling system is less pronounced in chronic immune-mediated inflammatory processes than in acute inflammation.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; Novosibirsk State Pedagogical University, Russia. lemen@soramn.ru.
authors.forename: E B
authors.initials: EB
authors.lastname: Menshchikova
authors.forename: N K
authors.initials: NK
authors.lastname: Zenkov
authors.forename: V O
authors.initials: VO
authors.lastname: Tkachev
authors.forename: A E
authors.initials: AE
authors.lastname: Lemza
authors.forename: N V
authors.initials: NV
authors.lastname: Kandalintseva
mesh_terms: D000818:Animals; D061745:Antioxidant Response Elements / Q000187:drug effects / Q000502:physiology*; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000188:drug therapy*; D003094:Collagen / Q000009:adverse effects; D005434:Flow Cytometry; D006861:Hydrogen Peroxide / Q000378:metabolism; D007249:Inflammation / Q000517:prevention & control*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D018709:Statistics, Nonparametric; D013886:Thiosulfonic Acids / Q000494:pharmacology*
chemical_list: C553321:3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonic acid; D013886:Thiosulfonic Acids; D003094:Collagen; D006861:Hydrogen Peroxide