title: New treatment strategies to eradicate cancer stem cells and niches in glioblastoma.
abstract: Glioblastoma multiforme (GBM) harbors are not only rapidly dividing cells but also small populations of slowly dividing and dormant cells with tumorigenesity, self-renewal, and multi-lineage differentiation capabilities. Known as glioblastoma stem cells (GSCs), they are resistant to conventional chemo- and radiotherapy and may be a causative factor in recurrence. The treatment outcome in patients with GBM remains unsatisfactory and their mean survival time has not improved sufficiently. We studied clinical evidence and basic research findings to assess the possibility of new treatment strategies that target GSCs and their specific microenvironments (GBM niches) and raise the possibility of adding new treatments to eradicate GSCs and GBM niches.
authors.forename: Takuichiro
authors.initials: T
authors.lastname: Hide
authors.forename: Keishi
authors.initials: K
authors.lastname: Makino
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakamura
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yano
authors.forename: Shigeo
authors.initials: S
authors.lastname: Anai
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takezaki
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Kuroda
authors.forename: Naoki
authors.initials: N
authors.lastname: Shinojima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ueda
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000502:physiology; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D011836:Radiation Tolerance; D015398:Signal Transduction / Q000187:drug effects; D055153:Stem Cell Niche; D035703:Therapies, Investigational; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins; D014212:Tretinoin