title: A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai, 200237 (China).
authors.forename: Le
authors.initials: L
authors.lastname: Han
authors.forename: Ganesh N
authors.initials: GN
authors.lastname: Pandian
authors.forename: Syed
authors.initials: S
authors.lastname: Junetha
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sato
authors.forename: Chandran
authors.initials: C
authors.lastname: Anandhakumar
authors.forename: Junichi
authors.initials: J
authors.lastname: Taniguchi
authors.forename: Abhijit
authors.initials: A
authors.lastname: Saha
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Bando
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nagase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000378:metabolism* / Q000473:pathology; D011758:Pyrroles / Q000737:chemistry / Q000378:metabolism; D015533:Transcriptional Activation / Q000187:drug effects / Q000235:genetics*
chemical_list: D006877:Hydroxamic Acids; D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; C029899:imidazole
keywords: DNA recognition; genetic switches; polymerase chain reaction; proteins; synthetic biology