title: Effect of prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on the course of experimental depressive syndrome in rats.
abstract: The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. The inhibitor (3.0 mg/kg, i.p., 30 min before pre-neurotoxin injection on days 8-14) alleviated depression symptoms and promoted normalization of behavioral activity after drug withdrawal. The obtained data reflected therapeutic antidepressant properties of inhibitor for prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine.
authors.affiliation: Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences; Laboratory for Psychopharmacology, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. nanikh@yandex.ru.
authors.forename: N N
authors.initials: NN
authors.lastname: Khlebnikova
authors.forename: N A
authors.initials: NA
authors.lastname: Krupina
authors.forename: N G
authors.initials: NG
authors.lastname: Bogdanova
authors.forename: I N
authors.initials: IN
authors.lastname: Orlova
authors.forename: N N
authors.initials: NN
authors.lastname: Zolotov
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000818:Animals; D001007:Anxiety / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight; D003866:Depressive Disorder / Q000188:drug therapy*; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D004298:Dopamine / Q000172:deficiency*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000085822:Prolyl Oligopeptidases; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism
chemical_list: D011759:Pyrrolidines; C543067:benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine; C542626:methionyl-2-cyanopyrrolidine; D013395:Sucrose; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008715:Methionine; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D004298:Dopamine