title: Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.
abstract: This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.
authors.affiliation: Cancer Research Program, JLC-BBRI, North Carolina Central University, Durham, North Carolina.|Department of Cardiovascular and Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Cancer Research Program, JLC-BBRI, North Carolina Central University, Durham, North Carolina.|Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Disease and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Medicine, UMDNJ-RWJMS, Medicine, New Brunswick, New Jersey.
authors.forename: Manisha
authors.initials: M
authors.lastname: Bajpai
authors.affiliation: Department of Medicine, UMDNJ-RWJMS, Medicine, New Brunswick, New Jersey.
authors.forename: Amit
authors.initials: A
authors.lastname: Verma
authors.affiliation: Department of Medicine, UMDNJ-RWJMS, Medicine, New Brunswick, New Jersey.
authors.forename: Kiron M
authors.initials: KM
authors.lastname: Das
authors.affiliation: Department of Medicine, University of Texas Southwestern Medical Center and the VA North Texas Health Care System, Dallas, Texas.
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Souza
authors.affiliation: Department of Medicine, Duke University, Durham, North Carolina.
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Garman
authors.affiliation: Trinity College Dublin/St. James' Hospital, Trinity Centre for Health Sciences, St. James' Hospital, Dublin, Ireland.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Donohoe
authors.affiliation: Trinity College Dublin/St. James' Hospital, Trinity Centre for Health Sciences, St. James' Hospital, Dublin, Ireland.
authors.forename: Naoimh J
authors.initials: NJ
authors.lastname: O'Farrell
authors.affiliation: Trinity College Dublin/St. James' Hospital, Trinity Centre for Health Sciences, St. James' Hospital, Dublin, Ireland.
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
authors.affiliation: Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona.
authors.forename: Katerina
authors.initials: K
authors.lastname: Dvorak
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001471:Barrett Esophagus / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019175:DNA Methylation; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor
keywords: Barrett's esophagus; DNA methylation; autophagy; esophageal adenocarcinoma; obesity