title: Targeted topical and combination laser surgery for the treatment of angiofibromas.
abstract: OBJECTIVE
  The angiofibromas of Tuberous sclerosis (TS) is well described manifestation. Due to the progressive nature of the skin lesion, a safe and effective technique for treating these disfiguring skin lesions is needed.
  
  
  METHODS
  We report a targeted topical and combination laser technique for treating the angiofibromas of TS in one patient. This includes treatment with topical sirolimus, pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).
  
  
  RESULTS
  Improvement in the number and appearance of facial angiofibromas and erythema is noted, without scarring or adverse events.
  
  
  CONCLUSIONS
  The technique of targeted therapy with sirolimus with electrosurgery, pulsed dye laser treatment, and AFR represents an innovative, safe therapeutic option for treating facial angiofibromas associated with TS.
authors.affiliation: Laser and Skin Surgery Center of New York, New York, New York.
authors.forename: Yoon-Soo Cindy
authors.initials: YS
authors.lastname: Bae-Harboe
authors.forename: Roy G
authors.initials: RG
authors.lastname: Geronemus
mesh_terms: D000328:Adult; D018322:Angiofibroma / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004598:Electrosurgery / Q000379:methods*; D005153:Facial Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D054025:Lasers, Dye / Q000627:therapeutic use*; D020123:Sirolimus / Q000627:therapeutic use*; D014402:Tuberous Sclerosis / Q000150:complications*
chemical_list: D000903:Antibiotics, Antineoplastic; D020123:Sirolimus
keywords: angiofibromas; laser; pulsed dye; resurfacing; sirolimus; tuberous sclerosis