title: [Salvia miltiorrhiza as medicinal model plant].
abstract: Research on medicinal model organism is one of the core technologies to promote the modernization of traditional Chinese medicine (TCM). The research progress of Salvia miltiorrhiza as medicinal model plant is summarized in this paper. The genome of S. miltiorrhiza is small and its life cycle is short, as well as this plant can be stably genetically transformed. Because S. miltiorrhiza possesses the important medicinal and economic values, recently the transcriptome and genome of S. miltiorrhiza have been significantly recovered. The research prospect of S. miltiorrhiza as medicinal model plant in TCM was discussed, including biosynthesis of active components and their genetic regulation, relationship between quality of TCM and ecological environments, and selective breeding of good quality lines. Furthermore, as medicinal model plant, the construction of mutant library for S. miltiorrhiza, the genome map with high quality, and the functional genome should be investigated. Accompanying modern investigation of life sciences, the platform for medicinal model plant, S. miltiorrhiza, will be promoted to be established. It is important to develop the ethnopharmacology and new drugs around the world.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Song
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Luo
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Jiang
authors.initials: J
authors.lastname: Xu
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
mesh_terms: D045784:Abietanes / Q000096:biosynthesis / Q000235:genetics; D000475:Alkenes; D002874:Chromosome Mapping; D020834:Ethnopharmacology; D018745:Genome, Plant; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000235:genetics* / Q000378:metabolism; D059808:Polyphenols / Q000096:biosynthesis / Q000235:genetics; D027561:Salvia miltiorrhiza / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome
chemical_list: D045784:Abietanes; D000475:Alkenes; D059808:Polyphenols; C568740:salvianolic acid; C021751:tanshinone