title: MiR-378 inhibits progression of human gastric cancer MGC-803 cells by targeting MAPK1 in vitro.
abstract: Gastric cancer (GC) is one of the most common cancers and the leading cause of cancer-related deaths globally. The discovery of microRNAs (miRNAs) provides a new avenue for GC diagnostic and treatment regiments. Currently, a large number of miRNAs have been reported to be associated with the progression of GC, among which miR-378 has been examined to be downregulated in GC tissues and several cell lines. However, the function of miR-378 on GC cells and the mechanisms were less known. Here we found that ectopic expression of miR-378 could inhibit cell proliferation, cell cycle progression, cell migration as well as invasion, and induced cell apoptosis in GC cell line MGC-803. Moreover, we found that oncogene mitogen-activated protein kinase 1 (MAPK1) was a target gene of miR-378 in GC cells, and the tumor-suppressive role of miR-378 might be achieved by the direct interaction with MAPK1. Taken together, our results showed that miR-378 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the future.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Soochow University, SooChow, Jiangsu, PR China.
authors.forename: Bojian
authors.initials: B
authors.lastname: Fei
authors.forename: Haorong
authors.initials: H
authors.lastname: Wu
mesh_terms: D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D018450:Disease Progression; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000008:administration & dosage / Q000235:genetics*; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D014162:Transfection
chemical_list: C526012:MIRN378 microRNA, human; D035683:MicroRNAs; D019950:Mitogen-Activated Protein Kinase 1