title: Changing the hemodialysis prescription for hemodialysis patients with subdural and intracranial hemorrhage.
abstract: Although continuous modalities of renal replacement therapy offer an advantage to the patient with compromised cerebral perfusion and intracranial hypertension, they are generally limited to the intensive care unit setting. Many hemodialysis patients admitted with strokes and subdural hematoma are managed on general wards. As such, these patients are generally treated by intermittent hemodialysis, and their dialysis prescription should be altered to minimize changes in serum osmolality, and fall in blood pressure during dialysis. Such patients require more frequent but shorter dialysis sessions, using minimally bioincompatible small surface area dialyzers with lower blood flows, in combination with higher sodium and cooled dialysate. In patients at risk of intracranial hemorrhage and those with invasive intracranial monitoring, systemic anticoagulants should be avoided, choosing no anticoagulation protocols or regional anticoagulants.
authors.affiliation: UCL Center for Nephrology, University College London Medical School, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
mesh_terms: D015314:Dialysis Solutions / Q000008:administration & dosage / Q000009:adverse effects*; D006408:Hematoma, Subdural / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000209:etiology*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D015314:Dialysis Solutions
keywords: Hemodialysis; cerebral edema; extradural; intracranial hemorrhage