title: Synthesis, characterization, and anticancer activity of a series of ketone-N(4)-substituted thiosemicarbazones and their ruthenium(II) arene complexes.
abstract: A series of ketone-N(4)-substituted thiosemicarbazone (TSC) compounds (L1-L9) and their corresponding [(η(6)-p-cymene)Ru(II)(TSC)Cl](+/0) complexes (1-9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1-6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.
authors.affiliation: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization (Guangxi Teachers Education University), Ministry of Education, Nanning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.forename: Quanquan
authors.initials: Q
authors.lastname: Qian
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Li
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Lei
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiao
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.forename: Chusheng
authors.initials: C
authors.lastname: Huang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D004587:Electrophoresis, Agar Gel; D057809:HEK293 Cells / Q000187:drug effects; D006801:Humans; D007659:Ketones / Q000737:chemistry; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007659:Ketones; D013882:Thiosemicarbazones; D012428:Ruthenium; D004247:DNA