title: VLPs and particle strategies for cancer vaccines.
abstract: Effective delivery of tumor antigens to APCs is one of the key steps for eliciting a strong and durable immune response to tumors. Several cancer vaccines have been evaluated in clinical trials, based on soluble peptides, but results have not been fully satisfactory. To improve immunogenicity particles provide a valid strategy to display and/or incorporate epitopes which can be efficiently targeted to APCs for effective induction of adaptive immunity. In the present review, we report some leading technologies for developing particulate vaccines employed in cancer immunotherapy, highlighting the key parameters for a rational design to elicit both humoral and cellular responses.
authors.affiliation: Department of Pharmacy, University of Napoli Federico II, Via Domenico Montesano 49, 80131, Napoli, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ungaro
authors.forename: Claudia
authors.initials: C
authors.lastname: Conte
authors.forename: Fabiana
authors.initials: F
authors.lastname: Quaglia
authors.forename: Maria Lina
authors.initials: ML
authors.lastname: Tornesello
authors.forename: Franco M
authors.initials: FM
authors.lastname: Buonaguro
authors.forename: Luigi
authors.initials: L
authors.lastname: Buonaguro
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D004337:Drug Carriers / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage; D053758:Nanoparticles / Q000008:administration & dosage; D009369:Neoplasms / Q000628:therapy*; D014611:Vaccination / Q000379:methods*; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage* / Q000276:immunology*; D014780:Viruses
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D004337:Drug Carriers; D008081:Liposomes; D058425:Vaccines, Virus-Like Particle