title: [Moebius syndrome. Clinical case report].
abstract: BACKGROUND
  Moebius syndrome (MBS) is an infrequent disease, having an incidence of 1 in 10,000 births, mainly characterized by a congenital bilateral facial paralysis due to an agenesia of the sixth and seventh cranial nerves. In addition, orofacial and limb anomalies are frequently found in these patients. The diagnosis is fundamentally based on different clinical manifestations of the disorder.
  
  
  METHODS
  a female newborn with the clinical picture of Moebius syndrome is presented, and genetic or environmental aspects are discussed. Since the use of misoprostol for abortion and inducing uterine activity in combination with NSAIDs, the number of newborns with MBS associated with this drug has increased. Nowadays, either genetic or environmental factors are associated with MBS.
  
  
  CONCLUSIONS
  it is necessary that the general and medical community be aware of the risk of teratogenic effects of misoprostol, and the usefulness of genetic counseling whenever there is a newborn with Moebius syndrome.
authors.affiliation: Coordinación de Enseñanza e Investigación en Salud, Hospital de Gineco-Pediatría, Unidad de Medicina Familiar 31, Instituto Mexicano del Seguro Social (IMSS), Mexicali, Baja California, Mexico. yusvip@yahoo.com.
authors.forename: Yusvisaret
authors.initials: Y
authors.lastname: Palmer-Morales
authors.forename: Rosario Elena
authors.initials: RE
authors.lastname: Zárate-Márquez
authors.forename: Roberto
authors.initials: R
authors.lastname: Prince-Vélez
authors.forename: Roberto
authors.initials: R
authors.lastname: González-Méndez
authors.forename: Thania Ayerim
authors.initials: TA
authors.lastname: Zamarripa-Sandoval
authors.forename: Nahim
authors.initials: N
authors.lastname: Verdugo-Salazar
authors.forename: Victor Gabriel
authors.initials: VG
authors.lastname: Torres-Félix
authors.forename: Remigio
authors.initials: R
authors.lastname: Salcido-Daniel
authors.forename: Pedro
authors.initials: P
authors.lastname: Valdez-Hernández
authors.forename: Andrés
authors.initials: A
authors.lastname: Morfín-Vela
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020331:Mobius Syndrome / Q000175:diagnosis*
keywords: Moebius syndrome; facial paralysis; parálisis facial; síndrome de Moebius