title: Palladium-catalyzed phosphonylation: synthesis of C3-, C4-, and C5-phosphonylated pyrazoles.
abstract: A palladium-catalyzed cross-coupling between 3-, 4-, and 5-halo-pyrazoles and H-phosphonates, H-phosphinates, and secondary phosphine oxides has been developed. This coupling reaction constitutes the first general method allowing the introduction of a great diversity of phosphorus substituents on the different carbons of the pyrazole ring in a one-step process.
authors.affiliation: Laboratoire de Chimie Organique, associé au CNRS, ESPCI , 10 rue Vauquelin, 75231 Paris Cedex 05, France, and Bayer S.A.S.-CRLD , 14 Impasse Pierre Baizet, CS 99163, 69263 Lyon Cedex 09, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Tran
authors.forename: Domingo
authors.initials: D
authors.lastname: Gomez Pardo
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Stefan
authors.initials: S
authors.lastname: Hillebrand
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010720:Phosphines; D011720:Pyrazoles; C031280:pyrazole; D010165:Palladium