title: First report of the predominance of clonal complex 398 Staphylococcus aureus strains in osteomyelitis complicating diabetic foot ulcers: a national French study.
abstract: Staphylococcus aureus is the most common pathogen cultured from diabetic foot infection including diabetic foot osteomyelitis. This French multicentre study determined the genetic content of S. aureus isolated from 157 consecutive cases admitted to 12 diabetic foot centres between 2008 and 2011. We describe for the first time the emergence of the CC398 methicillin-susceptible S. aureus clone, the main clone in diabetic foot osteomyelitis, and its tropism for bone. This clone spreads to humans from an animal source through its intrinsic virulence. This adaptation of S. aureus isolates looks to be a worrisome problem and should be carefully monitored.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, CH Dron, Tourcoing, France.
authors.forename: E
authors.initials: E
authors.lastname: Senneville
authors.forename: M
authors.initials: M
authors.lastname: Brière
authors.forename: C
authors.initials: C
authors.lastname: Neut
authors.forename: N
authors.initials: N
authors.lastname: Messad
authors.forename: G
authors.initials: G
authors.lastname: Lina
authors.forename: J-L
authors.initials: JL
authors.lastname: Richard
authors.forename: A
authors.initials: A
authors.lastname: Sotto
authors.forename: J-P
authors.initials: JP
authors.lastname: Lavigne
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D017719:Diabetic Foot / Q000150:complications*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D017720:Molecular Epidemiology; D058889:Molecular Typing; D010019:Osteomyelitis / Q000453:epidemiology* / Q000382:microbiology*; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D014774:Virulence
keywords: Clonal complex 398; diabetic foot; methicillin-susceptible Staphylococcus aureus; osteomyelitis