title: A description of the methodology used in an overview of reviews to evaluate evidence on the treatment, harms, diagnosis/classification, prognosis and outcomes used in the management of neck pain.
abstract: BACKGROUND
  Neck Pain (NP) is a common musculoskeletal disorder and the literature provides conflicting evidence about its management.
  
  
  OBJECTIVE
  To describe the methodology used to conduct an overview of reviews (OvR) and to characterize the distribution and risk of bias profiles across the evidence for all areas of NP management.
  
  
  METHODS
  Standard systematic review (SR) methodology was employed. MEDLINE, CINAHL, EMBASE, ILC, Cochrane CENTRAL, and LILACS were searched from 2000 to March 2012; Narrative and SR and clinical practice guidelines (CPG) evaluating the efficacy of treatment (benefits and harms), diagnosis/classification, prognosis, and outcomes were eligible. For treatment, articles were limited to SRs from 2005 forward. Risk of bias of SR was assessed with the AMSTAR; the AGREE II was used to critically appraise the CPGs.
  
  
  RESULTS
  From 2476 articles, 508 were eligible for full text screening. A total of 341 articles were included. Treatment (n=117) had the greatest yield. Other clinical areas had less literature (diagnosis=54, prognosis=16, outcomes=27, harms=16). There were no SR for classification and narrative reviews were problematic for this topic. There was great overlap across different databases within each clinical area except for those for outcome measures. Risk of bias assessment using the AMSTAR of eligible SRs showed a similar trend across different clinical areas.
  
  
  CONCLUSIONS
  A summary of methods used to review the literature in five clinical areas of NP management have been described. The challenges of selecting and synthesizing eligible articles in an OvR required customized solutions across different areas of clinical focus.
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: P Lina
authors.initials: PL
authors.lastname: Santaguida
authors.forename: Homa
authors.initials: H
authors.lastname: Keshavarz
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Carlesso
authors.forename: Margaret
authors.initials: M
authors.lastname: Lomotan
authors.forename: Anita
authors.initials: A
authors.lastname: Gross
authors.forename: Joy C
authors.initials: JC
authors.lastname: Macdermid
authors.forename: David M
authors.initials: DM
authors.lastname: Walton
keywords: Evidence syntheses; neck pain.; overview of reviews