title: Bone: Strontium ranelate does not have an anabolic effect on bone.
abstract: Strontium ranelate, a therapeutic for osteoporosis, was thought to have a dual mode of action, simultaneously stimulating bone formation and reducing resorption. A recent study casts doubt on this explanation, suggesting instead that it has a mild suppressive effect on bone formation with little effect on bone resorption.
authors.affiliation: King's College London, Osteoporosis Screening and Research Unit, King's College Academic Health Partners, 1st Floor, Tower Wing, Guy's Hospital, Guy's Campus, London SE1 9RT, UK.
authors.forename: Glen M
authors.initials: GM
authors.lastname: Blake
authors.forename: Ignac
authors.initials: I
authors.lastname: Fogelman
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use*; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D045930:Anabolic Agents; D013876:Thiophenes; C081587:strontium ranelate