title: Validating the Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) in Italian inpatients with chronic migraine with a history of medication overuse.
abstract: OBJECTIVE
  The purpose of the study is to assess validity, reliability and factor structure of the Italian version of Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) in patients suffering from chronic migraine (CM) with a history of medication overuse (MO).
  
  
  METHODS
  Patients were enrolled at hospital admission for withdrawal from MO. Factor analysis was used to confirm the latent structure of the MSQ. Reliability was measured with Cronbach's alpha coefficient, item-total correlation and inter-item correlation. Construct validity was assessed with Pearson's coefficient and known-group analysis.
  
  
  RESULTS
  The three-factor structure is basically confirmed. Cronbach's alpha varied between 0.85 and 0.92; item-total correlations were on average higher than 0.70; average inter-item correlation ranged between 0.63 and 0.65. Correlations were all significant; known-group analysis shows that MSQ score was lower consistently with disease severity.
  
  
  CONCLUSIONS
  Our findings confirm the factor structure, reliability and validity of the MSQ and expand results of previous validation studies to the Italian language and to a group of patients with severe CM requiring withdrawal treatment for MO.
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy, araggi@istituto-besta.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Raggi
authors.forename: Ambra Mara
authors.initials: AM
authors.lastname: Giovannetti
authors.forename: Silvia
authors.initials: S
authors.lastname: Schiavolin
authors.forename: Matilde
authors.initials: M
authors.lastname: Leonardi
authors.forename: Gennaro
authors.initials: G
authors.lastname: Bussone
authors.forename: Licia
authors.initials: L
authors.lastname: Grazzi
authors.forename: Susanna
authors.initials: S
authors.lastname: Usai
authors.forename: Marcella
authors.initials: M
authors.lastname: Curone
authors.forename: Paola
authors.initials: P
authors.lastname: Di Fiore
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Amico
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005260:Female; D006306:Health Surveys; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D007558:Italy; D007802:Language; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D063487:Prescription Drug Misuse; D011594:Psychometrics / Q000706:statistics & numerical data*; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000592:standards*; D055815:Young Adult