title: Use of inclusion complex of cyclodextrin with ambenonium to improve the treatment of anticholinesterase poisoning.
abstract: The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls.
authors.affiliation: Research and Testing Institute of Military Medicine, S. M. Kirov Military Medical Academy, St. Petersburg, Russia. mihei_bridge@mail.ru.
authors.forename: M A
authors.initials: MA
authors.lastname: Yudin
authors.forename: I M
authors.initials: IM
authors.lastname: Ivanov
authors.forename: A S
authors.initials: AS
authors.lastname: Nikiforov
authors.forename: T M
authors.initials: TM
authors.lastname: Kornyukhina
authors.forename: M A
authors.initials: MA
authors.lastname: Tyunin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000549:Ambenonium Chloride / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000506:poisoning* / Q000633:toxicity; D004338:Drug Combinations; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D047392:beta-Cyclodextrins / Q000627:therapeutic use*
chemical_list: D002800:Cholinesterase Inhibitors; D004338:Drug Combinations; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D000549:Ambenonium Chloride; D000110:Acetylcholinesterase