title: Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease.
abstract: Cerebral microinfarcts (CMIs) are a common finding in neuropathological studies of aging and dementia. Recently, it has become possible to detect CMIs in vivo. We studied CMI occurrence in 29 patients with mild cognitive impairment or early Alzheimer's disease (AD) and 22 non-demented individuals on 7Tesla MRI. CMI occurrence in patients (55%) and controls (45%) was not significantly different. In patients, CMI number tended to be related to microbleed number (p = 0.07). This first in vivo study of CMIs in early AD does not confirm findings from autopsy studies. Further studies are needed to clarify the role of CMIs in AD.
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Susanne J
authors.initials: SJ
authors.lastname: van Veluw
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Sophie M
authors.initials: SM
authors.lastname: Heringa
authors.affiliation: Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Kuijf
authors.affiliation: Department of Geriatrics, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Huiberdina L
authors.initials: HL
authors.lastname: Koek
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Biessels
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology*; D001344:Autopsy; D002544:Cerebral Infarction / Q000150:complications* / Q000175:diagnosis*; D003072:Cognition Disorders / Q000209:etiology; D060825:Cognitive Dysfunction / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values
keywords: Alzheimer's disease; magnetic resonance imaging; microbleeds; microinfarcts; mild cognitive impairment