title: Comparative analysis of pancreatic changes in aged rats fed life long with sunflower, fish, or olive oils.
abstract: An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related pancreatic disorders. We aimed to study the effect of oil consumption on pancreas histology in order to find aging-related signs. To this end, three groups of rats were fed an isocaloric diet for 2 years, where virgin olive, sunflower, or fish oil was included. Pancreatic samples for microscopy and blood samples were collected at the moment of sacrifice. As a result, the sunflower oil-fed rats presented higher β-cell numbers and twice the insulin content than virgin olive oil-fed animals. In addition, rats fed with fish oil developed acinar fibrosis and macrophage infiltrates in peri-insular regions, compared with counterparts fed with virgin olive oil. Inflammation signs were less prominent in the sunflower group. The obtained data emphasize the importance of dietary fatty acids in determining pancreatic structure.
authors.affiliation: Bioengineering Institute, University Miguel Hernandez, Elche (Alicante), Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Roche
authors.affiliation: Department of Pathology, Complejo Hospitalario de Jaén, Spain.
authors.forename: César L
authors.initials: CL
authors.lastname: Ramírez-Tortosa
authors.affiliation: Bioengineering Institute, University Miguel Hernandez, Elche (Alicante), Spain.
authors.forename: María I
authors.initials: MI
authors.lastname: Arribas
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain.
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Ochoa
authors.affiliation: Department of Analytical Chemistry, Nutrition and Bromatology, University of Alicante, Spain.
authors.forename: José E
authors.initials: JE
authors.lastname: Sirvent-Belando
authors.affiliation: Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Biochemistry and Molecular Biology II, University of Granada, Spain.
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Ramírez-Tortosa
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain.
authors.forename: Adrián
authors.initials: A
authors.lastname: González-Alonso
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain.
authors.forename: M Patricia
authors.initials: MP
authors.lastname: Pérez-López
authors.affiliation: Institute of Nutrition and Food Technology "José Mataix Verdú" and Department of Physiology, University of Granada, Spain. jlquiles@ugr.es.
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
mesh_terms: D061354:Acinar Cells / Q000473:pathology; D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology*; D005355:Fibrosis; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D005934:Glucagon / Q000378:metabolism; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D008297:Male; D000069463:Olive Oil; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000074242:Sunflower Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D007328:Insulin; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D005934:Glucagon
keywords: Endocrine pancreas; Exocrine pancreas; Pancreatic aging; Pancreatic fibrosis of the elderly.; β-Cell