title: Iron-catalyzed oxidative C-H/C-H cross-coupling: an efficient route to α-quaternary α-amino acid derivatives.
abstract: Fully loaded: A coordinating activation strategy has been developed to furnish α-quaternary α-amino acids through the iron(III)-catalyzed oxidative functionalization of α-C(sp(3) )H bonds of α-tertiary α-amino acid esters. The reaction exhibits a broad substrate scope for both α-amino acids and nucleophiles (Nu) as well as good functional-group tolerance (see scheme, DTBP=di-tert-butyl peroxide, DCE=1,2-dichloroethane).
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (PR China).
authors.forename: Kaizhi
authors.initials: K
authors.lastname: Li
authors.forename: Guangying
authors.initials: G
authors.lastname: Tan
authors.forename: Jingsheng
authors.initials: J
authors.lastname: Huang
authors.forename: Feijie
authors.initials: F
authors.lastname: Song
authors.forename: Jingsong
authors.initials: J
authors.lastname: You
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000596:Amino Acids; D004952:Esters; D005290:Ferric Compounds
keywords: coordinating activation; cross-coupling; homogeneous catalysis; iron; α-quaternary α-amino acids