title: Autoimmune retinopathy associated with carcinoid tumour of the small bowel.
abstract: Cancer associated retinopathy (CAR) is an immune mediated paraneoplastic condition associated with vision loss. It has been associated with a variety of systemic malignancies. The primary clinical presentation is rapid, progressive vision loss. Rod and cone dysfunction can cause other associated symptoms, such as nyctalopia. Electrophysiological testing and detection of anti-retinal antibodies are used to confirm the diagnosis. To our knowledge we describe the first patient with CAR associated with a carcinoid tumour of the gastrointestinal system. Auto-antibodies against alpha enolase and carbonic anhydrase II were detected with western blotting. Electroretinogram findings were consistent with rod and cone dysfunction.
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address: s.ogra@auckland.ac.nz.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Ogra
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: Dianne
authors.initials: D
authors.lastname: Sharp
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: Helen
authors.initials: H
authors.lastname: Danesh-Meyer
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000209:etiology / Q000503:physiopathology; D002276:Carcinoid Tumor / Q000150:complications*; D004596:Electroretinography; D017809:Fatal Outcome; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications*; D008297:Male; D059545:Paraneoplastic Syndromes, Ocular / Q000209:etiology* / Q000503:physiopathology; D058609:Visual Field Tests
keywords: Alpha enolase; Autoimmune retinopathy; Cancer associated retinopathy; Carbonic anhydrase; Neuroendocrine tumour; Paraneoplastic syndromes (ocular)