title: Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: a community-based case-control study.
abstract: OBJECTIVE
  There are no data regarding the possible role of the single nucleotide polymorphism (SNP) of class I histone deacetylases (HDACs) in type 2 diabetes mellitus (DM). We designed this study to examine whether polymorphisms of HDACs can be implicated in that disease.
  
  
  METHODS
  A community-based, case-control study was conducted, with a total of 568 subjects (284 patients and 284 controls) enrolled. Four polymorphisms of HDAC1 (rs1741981) and HDAC3 (rs11741808, rs2547547, rs2530223) were examined by the use of TaqMan technology.
  
  
  RESULTS
  We found a significant association with risk of type 2 DM for three SNPs of HDAC3, including rs11741808 [odds ratio (OR)=0.53, 95% confidence interval (CI): 0.35-0.81], rs2547547 [OR=1.72, 95% CI: 1.13-2.64], and rs2530223 [OR=1.39; 95% CI: 1.01-1.91]. Subgroup analysis showed that BMI≥23kg/m(2), high triglyceride and high blood pressure, together with the rs11741808AG genotype, were associated with a significantly decreased risk for type 2 DM, with ORs of 0.50 (95% CI: 0.27-0.91), 0.38 (95% CI: 0.20-0.71) and 0.43 (95% CI: 0.24-0.76) compared with the AA genotype, respectively. In a population with normal total cholesterol, the AG genotype yielded a significantly decreased risk of type 2 DM risk, with an OR of 0.42 (95% CI: 0.25-0.70) when compared with the persons of the AA genotype. For rs2547547, in a population with normal total cholesterol and triglyceride, the AG genotype was associated with a significantly increased risk of type 2 DM, with ORs of 1.92 (95% CI: 1.17-3.15) and 2.24 (95% CI: 1.28-3.94) when compared with the population carrying the AA genotype.
  
  
  CONCLUSIONS
  The results suggest that variants of HDAC3 contribute to an increased prevalence of type 2 DM in the Chinese Han population.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; School of Public Health, Guangdong Key Laboratory of Molecular Epidemiology, Guangdong Pharmaceutical University, Guangzhou 510310, China.
authors.forename: Zhuanping
authors.initials: Z
authors.lastname: Zeng
authors.forename: Rifang
authors.initials: R
authors.lastname: Liao
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Yao
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Xueyan
authors.initials: X
authors.lastname: Zheng
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Huang
authors.forename: Sidong
authors.initials: S
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000368:Aged; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D056284:Histone Deacetylase 1 / Q000235:genetics; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000099186:Histone Deacetylase 3
chemical_list: D056284:Histone Deacetylase 1; D006655:Histone Deacetylases; D000099186:Histone Deacetylase 3; C110550:HDAC1 protein, human
keywords: BMI; Case–control study; HDACs; Histone deacetylase; IGR; MAF; OR(G); SNP; Single-nucleotide polymorphism; Type 2 DM; Type 2 diabetes mellitus; body mass index; generalized odds ratio; histone deacetylases; impaired glucose regulation; minor allele frequency; single nucleotide polymorphism; type 2 diabetes mellitus