title: Surgical treatment and adjuvant therapies of recurrent respiratory papillomatosis.
abstract: Recurrent respiratory papillomatosis or recurrent laryngeal papillomatosis is a disease of the larynx caused by human papilloma virus, characterized by verrucous epithelial lesions and usually recurring. In the literature there are several types of treatment, such as surgery to cold, laser and/or use of microdebrider, as of adjuvant therapies; all possible to decrease the permanent sequelae of the disease.
  
  
  OBJECTIVE
  To review the literature regarding this disease with emphasis on surgical techniques and adjuvant therapies used today.
  
  
  METHODS
  We used the literature review, through surveys based electronic data in the public domain, to search for articles between 1992-2012, using keywords: papilloma, human papilloma virus infection, larynx, therapeutic, papilloma virus vaccine.
  
  
  RESULTS
  We surveyed 357 articles, of which 49 were used as the basis for this review. Scientific studies indicate a reduction of relapse in most adjuvant therapeutic presented. However, the survey showed different methodologies and samples, which did not allow to compare the types of treatment and adjuvant therapies.
  
  
  CONCLUSIONS
  The choice of surgical technique varies among studies, but there is a trend to use the microdebrider. The newer adjuvant therapies, such as cidofovir, quadrivalent vaccine against human papilloma virus and bevacizumab, require further studies.
authors.affiliation: UNIFESP, EPM.
authors.forename: Melissa Ameloti Gomes
authors.initials: MA
authors.lastname: Avelino
authors.forename: Tallyta Campos Domingues Teixeira
authors.initials: TC
authors.lastname: Zaiden
authors.forename: Raquel Oliveira
authors.initials: RO
authors.lastname: Gomes
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000601:surgery*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000998:Antiviral Agents