title: [Trends in incidence of and mortality from ischaemic stroke].
abstract: OBJECTIVE
  To investigate age- and sex-specific trends in incidence of and mortality from ischaemic stroke (IS) in the Netherlands.
  
  
  METHODS
  Descriptive study and cohort study.
  
  
  METHODS
  Data from the cause-of-death statistics from Statistics Netherlands, the Dutch national medical registry and local council population registers were used. A cohort of IS patients was formed by linking these registers. Age- and sex-specific trends in mortality from IS in the period 1980-2010 were determined using 'join point' regression analysis. The 30-day and 1-year mortality rates following hospital admission for IS and the incidence of new cases of IS were calculated for the cohort of IS patients. Mann-Kendall tests were used for trend analysis over the period 1997-2005.
  
  
  RESULTS
  Rates of mortality from IS decreased gradually in the period 1980-2000, with the exception of a levelling out of the rate of decrease in a few age groups in the 1990 s. Decrease in mortality declined dramatically after 2000 in all age groups, except for male patients in the age range 35-64 years. A comparative increased rate of decrease after 2000 was observed for 30-day and 1-year mortality following hospital admission for IS. The incidence of IS remained constant in the period 1997-2005, or increased in a few age groups.
  
  
  CONCLUSIONS
  Mortality rates following IS have decreased dramatically in the Netherlands since 2000. However, the number of cases of non-fatal IS has not decreased and is actually increasing slightly, indicating that more people have experienced IS. This is a concern, since IS often leads to disability with the accompanying burden of disease and economic burden. Prevention of IS is, therefore, extremely important.
authors.affiliation: *Dit onderzoek werd eerder gepubliceerd in Stroke (2013;44:591-7) met als titel 'Remarkable decline in ischemic stroke mortality is not matched by changes in incidence'. Afgedrukt met toestemming.
authors.forename: Ilonca
authors.initials: I
authors.lastname: Vaartjes
authors.forename: Martin
authors.initials: M
authors.lastname: O'Flaherty
authors.forename: Simon
authors.initials: S
authors.lastname: Capewell
authors.forename: Jaap L
authors.initials: JL
authors.lastname: Kappelle
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D006233:Persons with Disabilities; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D009426:Netherlands / Q000453:epidemiology; D012042:Registries; D020521:Stroke / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control; D015996:Survival Rate; D013997:Time Factors