title: Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities.
abstract: The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds 5a-j and also their antioxidant activities. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. On the other hand, compounds 5g and 5j exhibited moderate antioxidant activity.
authors.affiliation: Department of Chemistry, Yuvaraja's College Mysore, University of Mysore, Mysore, Karnataka, India.
authors.forename: Handuvinahalli Devanna
authors.initials: HD
authors.lastname: Gurupadaswamy
authors.forename: Virupaksha
authors.initials: V
authors.lastname: Girish
authors.forename: Farhan
authors.initials: F
authors.lastname: Zameer
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Hegdekatte
authors.forename: Jyoti Bala
authors.initials: JB
authors.lastname: Chauhan
authors.forename: Shaukath Ara
authors.initials: SA
authors.lastname: Khanum
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006074:Gout Suppressants / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014527:Uric Acid / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D006074:Gout Suppressants; D011744:Pyrimidinones; D014527:Uric Acid; D014969:Xanthine Oxidase
keywords: Antioxidant activity; Pyrimidones; Xanthine oxidase inhibitory activity