title: Cerebral microbleeds and macrobleeds: should they influence our recommendations for antithrombotic therapies?
abstract: Intracerebral hemorrhage (ICH, or macrobleeds) and cerebral microbleeds-smaller foci of hemosiderin deposits commonly detected by magnetic resonance imaging of older adults with or without ICH-are both associated with an increased risk of future ICH. These hemorrhagic pathologies also share risk factors with ischemic thromboembolic conditions that may require antithrombotic therapy, requiring specialists in cardiology, internal medicine, and neurology to weigh the benefits vs hemorrhagic risks of antithrombotics in individual patients. This paper will review recent advances in our understanding of hemorrhage prone cerebrovascular pathologies with a particular emphasis on use of these markers in decision making for antithrombotic use.
authors.affiliation: .
authors.forename: Kellen E
authors.initials: KE
authors.lastname: Haley
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.affiliation: Massachusetts General Hospital, Stroke Service, 175 Cambridge Street #300, Boston, MA 02114, USA edip@mail.harvard.edu
authors.forename: M Edip
authors.initials: ME
authors.lastname: Gurol
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D016657:Cerebral Amyloid Angiopathy / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D056784:Leukoencephalopathies / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D018579:Patient Selection; D012307:Risk Factors; D012806:Siderosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D020521:Stroke / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology
chemical_list: D000925:Anticoagulants