title: Gastrointestinal sensitivity and gastroesophageal reflux disease.
abstract: This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.
authors.affiliation: Department of Digestive Disease, Campus Bio-medico University, Rome, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Altomare
authors.affiliation: Department of Digestive Disease, Campus Bio-medico University, Rome, Italy.
authors.forename: Michele Pier
authors.initials: MP
authors.lastname: Luca Guarino Sara Emerenziani
authors.affiliation: Department of Digestive Disease, Campus Bio-medico University, Rome, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Cicala
authors.affiliation: Mech-Sense, Departments of Gastroenterology & Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Asbjørn Mohr
authors.initials: AM
authors.lastname: Drewes
authors.affiliation: Mech-Sense, Departments of Gastroenterology & Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Anne Lund
authors.initials: AL
authors.lastname: Krarup
authors.affiliation: Mech-Sense, Departments of Gastroenterology & Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Christina
authors.initials: C
authors.lastname: Brock
authors.affiliation: Mech-Sense, Departments of Gastroenterology & Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Lottrup
authors.affiliation: Mech-Sense, Departments of Gastroenterology & Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Jens Brøndum
authors.initials: JB
authors.lastname: Frøkjaer
authors.affiliation: Departments of Medicine, University of Texas Southwestern Medical Center and the VA North Texas Health Care System, Dallas, Texas.
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Souza
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, University "Federico II,", Naples, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Nardone
authors.affiliation: Department of Clinical and Experimental Medicine, Gastroenterology Unit, University "Federico II,", Naples, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Compare
mesh_terms: D005764:Gastroesophageal Reflux / Q000378:metabolism / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D010146:Pain / Q000378:metabolism / Q000503:physiopathology*; D011983:Receptors, Purinergic / Q000378:metabolism; D050916:TRPV Cation Channels / Q000378:metabolism
chemical_list: D011983:Receptors, Purinergic; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
keywords: ATP; GERD; PAR2; TRPV1; pain; purinergic receptors