title: Preparation and degradation study of photocurable oligolactide-HA composite: a potential resin for stereolithography application.
abstract: The merging of stereolithography (SLA) technology to the medical field certainly benefits the manufacturing of parts, especially those patient-specific for the clinical use. This technique, however, has hardly been exploited medically due to a limited number of biodegradable resins for SLA processing. To extend application of SLA in the biomedical field, photocurable oligolactide resins were developed and examined for biodegradation and biocompatibility. The degradation was studied by monitoring the changes in weight loss, and thermal and mechanical properties of the photocured specimens in phosphate buffered saline (PBS) at 37°C. The results demonstrated that a resin composition played an important role in degradation, and the retarded degradation rate was observed for the highly crosslinked resin containing hydroxyapatite (HA). The less cytotoxic sample was also obtained from the resin with higher content of HA. These findings suggest the possible use of the developed photocurable oligolactide resins in SLA manufacturing of biodegradable implants, where their degradation behaviors can be designed by varying the resin composition.
authors.affiliation: Biomedical Engineering Research Unit, National Metal and Materials Technology Center, 114 Thailand Science Park, Paholyothin Rd., Klong 1, Klong Luang, Pathumthani, 12120, Thailand.
authors.forename: Siriporn
authors.initials: S
authors.lastname: Tanodekaew
authors.forename: Somruethai
authors.initials: S
authors.lastname: Channasanon
authors.forename: Paweena
authors.initials: P
authors.lastname: Uppanan
mesh_terms: D000465:Algorithms; D000818:Animals; D063566:Biodegradable Plastics; D002470:Cell Survival; D004396:Coloring Agents; D003188:Composite Resins / Q000737:chemistry* / Q000633:toxicity; D004146:Dioxanes / Q000737:chemistry* / Q000633:toxicity; D005782:Gels; D006358:Hot Temperature; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D013778:Tetrazolium Salts; D013818:Thermogravimetry; D013844:Thiazoles
chemical_list: D063566:Biodegradable Plastics; D004396:Coloring Agents; D003188:Composite Resins; D004146:Dioxanes; D005782:Gels; D013778:Tetrazolium Salts; D013844:Thiazoles; D006820:Hyaluronic Acid; C091880:dilactide; C022616:thiazolyl blue
keywords: biocompatibility; degradation; hydroxyapatite; oligolactide