title: Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome.
abstract: Recombinant human soluble thrombomodulin (rhTM) is a promising therapeutic natural anticoagulant and is used clinically for the treatment of disseminated intravascular coagulation (DIC). Herein is reported the cases of two HUS children treated with rhTM. The patients were diagnosed as having typical HUS on the basis of thrombocytopenia, hemolytic anemia, acute renal failure, and the detection Escherichia coli 0157. I.v. rhTM was started as an anti-coagulant drug. At 2 days after the first treatment in both patients, fibrin/fibrinogen degradation products and d-dimer levels were significantly decreased, and there was a subsequent slight improvement in thrombocytopenia, and a decrease in serum lactate dehydrogenase level. Urinary protein excretion gradually diminished and a decrease in serum creatinine level was observed. The patients did not require dialysis therapy. The present results suggest that rhTM may be a safe and effective treatment for DIC complicated with HUS in children.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Suyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ono
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oikawa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ohara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Sakai
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D011994:Recombinant Proteins; D012189:Retrospective Studies; D018180:Thrombomodulin / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; C546931:THBD protein, human; D018180:Thrombomodulin; D003404:Creatinine
keywords: O-157. renal insufficiency; hemolytic uremic syndrome; recombinant human soluble thrombomodulin