title: Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion.
abstract: The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone.
authors.affiliation: V. A. Almazov Federal Center of Heart, Blood, and Endocrinology, the Ministry of Health and Social Development of Russia, St. Petersburg, Russia. Yury.V.Dmitriev@gmail.com.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Dmitriev
authors.forename: S M
authors.initials: SM
authors.lastname: Minasian
authors.forename: E A
authors.initials: EA
authors.lastname: Demchenko
authors.forename: M M
authors.initials: MM
authors.lastname: Galagudza
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006321:Heart; D006339:Heart Rate / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D009570:Nitriles / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D006575:Heterocyclic Compounds, 3-Ring; D007093:Imidazoles; D007211:Indoles; C519552:Necrostatin-5; D009570:Nitriles; C507699:necrostatin-1