title: Laryngopharyngeal reflux and GERD.
abstract: In patients with laryngopharygeal reflux (LPR), gastric contents exhibit retrograde flow into the upper aero-digestive tract, causing extraesophageal symptoms including chronic cough, hoarseness, indigestion, difficulty swallowing, globus pharyngis, and asthma. The following on laryngopharyngeal reflux includes commentaries on the use of patient-completed questionaires and anti-human pepsin antibodies and other non-invasive tests in diagnosis; the role of pepsin and acid in the etiologies of laryngeal cancers; and the application of proton pump inhibitor (PPI) therapy for the treatment of LPR.
authors.affiliation: Department of Otolaryngology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Nikki
authors.initials: N
authors.lastname: Johnston
authors.affiliation: Technostics Ltd, Castle Hill Hospital, Kingston-Upon-Hull, United Kingdom.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Dettmar
authors.affiliation: Technostics Ltd, Castle Hill Hospital, Kingston-Upon-Hull, United Kingdom.
authors.forename: Vicki
authors.initials: V
authors.lastname: Strugala
authors.affiliation: Department of Otolaryngology, North Shore Hospital, Auckland, New Zealand.
authors.forename: Jacqui E
authors.initials: JE
authors.lastname: Allen
authors.affiliation: Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts.
authors.forename: Walter W
authors.initials: WW
authors.lastname: Chan
mesh_terms: D003371:Cough / Q000209:etiology / Q000503:physiopathology; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006685:Hoarseness / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology
keywords: diagnostic tests; laryngeal cancer; larynopharyngeal reflux; pepsin; proton pump inhibitor