title: Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients.
abstract: BACKGROUND
  In surgical treatment of elderly patients, securing the safety of surgery and radical cure must be balanced. Our purpose was to verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.
  
  
  METHODS
  Patients with cTis–T4a colorectal cancer who were 75 years or older were randomized to receive open or laparoscopic surgery. Exclusion criteria were patients who had a bulky tumor, rectal cancer that required pelvic side wall lymphadenectomy, and history of colon resection. Patients were divided according to tumor location (right colon, left colon, and rectum). The short-term outcomes were compared between the two groups.
  
  
  RESULTS
  One hundred patients (right 43, left 28, and rectum 29) were registered in each group from August 2008 to August 2012. There were no differences in patient characteristics between the two groups. Three patients were converted from laparoscopic to open, because of bleeding, excision of peritoneum metastasis, and patient’s desire, respectively. In the short-term results (open:laparoscopic), there were significant differences in the rates of complications (36:23 %) and ileus (12:4 %), amount of blood loss (157:63 mL), and duration of surgery (150:172 min). There were no significant differences in the pathological margins, and the number of dissected lymph nodes. In the subgroup analysis according to the tumor location, there were significant differences in the rate of complications (39.4:22.5 %), amount of blood loss (135:42 mL), duration of surgery (139:160 min), and length of postoperative stay (13.0:10.0 days) in the colon cancer. There were no significant differences in short-term results in the rectal cancer.
  
  
  CONCLUSIONS
  Laparoscopic surgery in elderly colorectal cancer patients did not result in a difference in radical cure compared with open surgery, and the short-term results except the duration of surgery were excellent. It is an effective procedure for elderly patients with colorectal cancer, especially colon cancer.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fujii
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishibe
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ota
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Watanabe
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Amane
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Mari
authors.initials: M
authors.lastname: Oba
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D010535:Laparoscopy / Q000379:methods*; D007813:Laparotomy / Q000379:methods*; D008297:Male; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome