title: CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report.
abstract: Brain metastasis is a significant cause of morbidity and mortality and a critical complication of non-central nervous system primary carcinoma. The present study describes the clinical case of a 46-year-old male with lung cancer and life-threatening brain metastases. The patient was diagnosed with lung cancer with a clinical stage of T2N0M1 (stage IV). Six months after the initial diagnosis and administration of conformal radiotherapy combined with three cycles of chemotherapy, an enhanced computed tomography (CT) scan of the brain revealed abnormalities with double-dosing of intravenous contrast. The CT scan identified >24 lesions scattered in the whole brain. The patient was treated with three-fraction Cyberknife radiotherapy at 22 Gy, delivered to the brain metastases at the Center for Tumor Treatment of People's Liberation Army 107th Hospital. Following CyberKnife therapy, a CT scan of the brain revealed that most of the tumors had disappeared with almost no residual traces. The stereotactic radiosurgery (SRS) conducted using CyberKnife, an image-guided frameless robotic technology for whole-body radiosurgery, had produced a marked response. The present case report demonstrates that CyberKnife therapy plays a significant role in the management of multiple meta-static brain tumors.
authors.affiliation: Center for Tumor Treatment, People's Liberation Army 107th Hospital, Lai Shan Qu, Yantai, Shandong 264003, P.R. China ; Binzhou Medical College, Lai Shan Qu, Yantai, Shandong 264003, P.R. China.
authors.forename: Guiqing
authors.initials: G
authors.lastname: Yang
authors.forename: Yishan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Sixiang
authors.initials: S
authors.lastname: Lin
authors.forename: Dongning
authors.initials: D
authors.lastname: Sun
keywords: CyberKnife; brain tumor; lung cancer; metastases