title: Effect of anorexigenic peptide obestatin on platelet aggregation and osmotic resistance of erythrocytes.
abstract: We studied the effects of the anorexigenic peptide obestatin on the coagulation system and blood rheology (by the parameters of platelet aggregation and osmotic resistance of erythrocytes) in vitro and in vivo. Obestatin inhibited in vitro platelet aggregation in the entire dose range and reduced osmotic resistance of erythrocytes in all doses except 300 nmol/kg (obestatin in a dose of 300 nmol/kg had no effect on this parameter). Similar to the results of in vitro experiments, intranasal, intraperitoneal, and subcutaneous administration of obestatin in a dose of 300 nmol/kg inhibited platelet aggregation and had no effect on the osmotic resistance of erythrocytes.
authors.affiliation: Department of Human and Animal Physiology, Department of Biophysics, Faculty of Biology, Lomonosov Moscow State University, Russia. ekhirazova@gmail.com.
authors.forename: E E
authors.initials: EE
authors.lastname: Khirazova
authors.forename: M G
authors.initials: MG
authors.lastname: Golubeva
authors.forename: M V
authors.initials: MV
authors.lastname: Maslova
authors.forename: A V
authors.initials: AV
authors.lastname: Graf
authors.forename: A S
authors.initials: AS
authors.lastname: Maklakova
authors.forename: A A
authors.initials: AA
authors.lastname: Baizhumanov
authors.forename: L K
authors.initials: LK
authors.lastname: Trofimova
authors.forename: N A
authors.initials: NA
authors.lastname: Sokolova
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskii
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D001066:Appetite / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D009997:Osmotic Pressure / Q000187:drug effects*; D036361:Peptide Hormones / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
chemical_list: D036361:Peptide Hormones; C505798:obestatin, rat; D009569:Nitric Oxide; D000244:Adenosine Diphosphate