title: Use of high-sensitivity troponin for the diagnosis of acute myocardial infarction.
abstract: Although there is broad consensus that cardiac troponin I or T (cTn) is the preferred biomarker and complements clinical assessment and the 12-lead ECG in the early diagnosis of acute myocardial infarction, important uncertainties and questions remain on the value of high-sensitivity cTn assays, including their best clinical use. Although these assays have been introduced clinically in many countries, they still await regulatory approval in the USA. This review summarizes the recent advances and potential pitfalls in the clinical application of high-sensitivity cTn assays in the early diagnosis of acute myocardial infarction.
authors.affiliation: Department of Cardiology, University Hospital, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
mesh_terms: D015415:Biomarkers / Q000097:blood; D003935:Diagnostic Techniques, Cardiovascular / Q000592:standards*; D042241:Early Diagnosis; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D013997:Time Factors; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T