title: Effect of chlorpromazine on rat placenta development.
abstract: We examined the sequential histopathological changes in the placentas from rats exposed to chlorpromazine. Chlorpromazine was intraperitoneally administered on GD 14 at 50 and 100 mg/kg and the placentas were sampled on GDs 14.5, 15, 17 and 21. The incidence of dams with complete fetal resorption was increased from GD 17 up to 20% at 50 mg/kg and 44.4% at 100 mg/kg. The embryo/fetal weights reduced on GDs 15 and 17 at 50 mg/kg and during GDs 15-21 at 100 mg/kg. The placental weights reduced on GD 17 at 50 mg/kg and during GDs 14.5-21 at 100 mg/kg. Histopathologically, in the labyrinth zone, apoptotic cells were scattered in the trophoblastic septa without inhibition of cell proliferation on GDs 14.5 and 15 at 50 and 100 mg/kg in a dose-dependent manner. A decrease in trophoblasts led to labyrinth zone hypoplasia. In the basal zone, apoptotic cells were scattered on GDs 14.5 and 15 at 100 mg/kg, and most of them appeared to be glycogen cells. A decrease in glycogen cells induced the delayed development of glycogen cell islands and the subsequent remaining glycogen cell islands, and led to the cystic degeneration of glycogen cells. In addition, failure of development of the glycogen cell islands led to the impaired interstitial invasion of the glycogen cells, and then metrial gland hypoplasia occurred.
authors.affiliation: Biological Research Laboratories, Nissan Chemical Industries, Ltd., 1470 Shiraoka, Shiraoka-shi, Saitama 349-0294, Japan. Electronic address: furukawa@nissanchem.co.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Furukawa
authors.forename: Seigo
authors.initials: S
authors.lastname: Hayashi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Abe
authors.forename: Souichiro
authors.initials: S
authors.lastname: Hagio
authors.forename: Kota
authors.initials: K
authors.lastname: Irie
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Izumi
authors.initials: I
authors.lastname: Ogawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D002746:Chlorpromazine / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D020567:Fetal Weight / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D020287:In Situ Nick-End Labeling; D010920:Placenta / Q000187:drug effects* / Q000473:pathology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine
keywords: Basal zone; Chlorpromazine; Cystic degeneration; Glycogen cell; Rat