title: Detecting secondary structure and surface orientation of helical peptide monolayers from resonant hybridization signals.
abstract: Hybridization of dominant vibrational modes with meta-surface resonance allows detection of both structural changes and surface orientations of bound helical peptides. Depending on the resonance frequency of meta-molecules, a red- or blue- shift in peptide Amide-I frequency is observed. The underlying coupling mechanism is described by using a temporal coupled mode theory that is in very good agreement with the experimental results. This hybridization phenomenon constitutes the basis of many nanophotonic systems such as tunable coupled mode bio-sensors and dynamic peptide systems driven by infrared signals.
authors.affiliation: Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
authors.forename: Kamil Boratay
authors.initials: KB
authors.lastname: Alici
authors.forename: Ignacio F
authors.initials: IF
authors.lastname: Gallardo
mesh_terms: D000465:Algorithms; D000577:Amides / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared
chemical_list: D000577:Amides; D010455:Peptides