title: Three acetophenones from Acronychia pedunculata.
abstract: Phytochemical investigation of the leaves and twigs of Acronychia pedunculata has led to the isolation of three new acetophenone monomers 1-3 as well as 1-[2',4'-dihydroxy-3',5'-di-(3″-methyl-2″-butenyl)-6'-methoxy]phenylethanone (4), acronyculatin E (5), a mixture of β-sitosterol and stigmasterol, and sesamin. The structures of these new compounds were elucidated spectroscopically. The inhibitory activities of the isolated acetophenone derivatives against mammalian DNA polymerases and human cancer cell growth were also assessed.
authors.affiliation: Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kozaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takenaka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
authors.forename: Takao
authors.initials: T
authors.lastname: Yamaura
authors.forename: Takao
authors.initials: T
authors.lastname: Tanahashi
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019384:Nucleic Acid Synthesis Inhibitors; D051381:Rats; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors