title: Intramedullary gangliogliomas: clinical features, surgical outcomes, and neuropathic scoliosis.
abstract: Intramedullary spinal cord gangliogliomas are rare tumors composed of glial components and ganglion cells. These gangliogliomas are generally considered as slow-growing tumors, corresponding histologically to WHO grade I or II. There are few reports of large case series of intramedullary spinal cord gangliogliomas from a single center. We retrospectively reviewed a consecutive series of 18 patients with pathologically diagnosed ganglioglioma. Clinical manifestations, radiological features, treatment and follow-up data, and concomitant scoliosis were investigated. The mean age at diagnosis was 27.5 years, with a slight female predominance. The primary clinical symptoms were sensorimotor deficits. Magnetic resonance (MR) imaging manifestations varied considerably. Some associated, but not necessary, features were found, such as young age at onset, large tumor dimension, and bony changes. Scoliosis was observed in seven patients. Remnant tumor progression was observed in five patients during the follow-up period, and no deaths occurred. The last neurological evaluation showed functional improvement from preoperative status in five patients. Differential diagnosis of ganglioglioma based on MR images alone is challenging, but the combination of some characteristic features can be helpful. An accurate diagnosis of ganglioglioma depends on pathological criteria. Despite the benign course of ganglioglioma, considerable growth may affect its resectability and prognosis. The extent of resection should be meticulously planned, and the potential risk of recurrence and neurological deterioration should be evaluated. The concomitant scoliosis is noteworthy.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantan Xili, Chongwen District, Beijing, 100050, China.
authors.forename: Chenlong
authors.initials: C
authors.lastname: Yang
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.forename: Jingyi
authors.initials: J
authors.lastname: Fang
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Deng
authors.forename: Yulun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D019786:Gadolinium DTPA; D018303:Ganglioglioma / Q000150:complications / Q000473:pathology / Q000601:surgery; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D050765:Qa-SNARE Proteins / Q000378:metabolism; D012189:Retrospective Studies; D012600:Scoliosis / Q000209:etiology* / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014965:X-Rays; D055815:Young Adult
chemical_list: D005904:Glial Fibrillary Acidic Protein; D050765:Qa-SNARE Proteins; D010751:Phosphopyruvate Hydratase; D019786:Gadolinium DTPA