title: Prospecting genomes for lasso peptides.
abstract: Genome mining has unlocked a veritable treasure chest of natural compounds. However, each family of natural products requires a genome-mining approach tailored to its unique features to be successful. Lasso peptides are ribosomally synthesized and posttranslationally modified products with a unique three-dimensional structure. Advances in the understanding of these molecules have informed the design of strategies to identify new members of the class in sequenced genomes. This review presents the bioinformatic methods used to discover novel lasso peptides and describes how such analyses have afforded insights into the biosynthesis and evolution of this peptide class.
authors.affiliation: 207 Hoyt Laboratory, Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, 08544, USA.
authors.forename: Mikhail O
authors.initials: MO
authors.lastname: Maksimov
authors.forename: A James
authors.initials: AJ
authors.lastname: Link
mesh_terms: D000595:Amino Acid Sequence; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism*; D023281:Genomics / Q000379:methods*; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D001688:Biological Products; D010455:Peptides