title: Fetal anemia as a signal of congenital syphilis.
abstract: An upsurge in syphilis has been observed almost everywhere over the past decade. The mother's clinical presentation is often uninformative. The diagnosis of maternal syphilis infection is most often based on serologic tests that allow early Extencilline treatment. Syphilis ultrasound findings are non-specific, and delay before treatment can be decisive for prognosis. Fetal anemia is a physiological consequence of severe infection. We confirmed that syphilis can be suggested non-invasively by MCA-PSV measurements in a context of ascitis or atypical hydrops in the absence of usual causes. It is therefore important to perform maternal TPHA/VDRL serology if fetal anemia is suspected. In association with Extencilline treatment, intra uterine transfusion can limit consequences of infection. Reduced fetal movements and non-reactive fetal heart rate may prefigure acute perinatal complications or stillbirth.
authors.affiliation: Department of Obstetrics and Gynecology, Bocage Hospital, Burgundy University , Dijon , France .
authors.forename: Guillaume
authors.initials: G
authors.lastname: Macé
authors.forename: Vanina
authors.initials: V
authors.lastname: Castaigne
authors.forename: Aurore
authors.initials: A
authors.lastname: Trabbia
authors.forename: Virginie
authors.initials: V
authors.lastname: Guigue
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cynober
authors.forename: Anne
authors.initials: A
authors.lastname: Cortey
authors.forename: Valérie
authors.initials: V
authors.lastname: Lalande
authors.forename: Bruno
authors.initials: B
authors.lastname: Carbonne
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000382:microbiology*; D001201:Ascites / Q000382:microbiology*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000382:microbiology*; D006340:Heart Rate, Fetal; D006801:Humans; D011247:Pregnancy; D013590:Syphilis, Congenital / Q000150:complications* / Q000175:diagnosis
keywords: Anemia; congenital syphilis; fetal movements; intra uterine transfusion; prenatal