title: Students' self-explanations while solving unfamiliar cases: the role of biomedical knowledge.
abstract: OBJECTIVE
  General guidelines for teaching clinical reasoning have received much attention, despite a paucity of instructional approaches with demonstrated effectiveness. As suggested in a recent experimental study, self-explanation while solving clinical cases may be an effective strategy to foster reasoning in clinical clerks dealing with less familiar cases. However, the mechanisms that mediate this benefit have not been specifically investigated. The aim of this study was to explore the types of knowledge used by students when solving familiar and less familiar clinical cases with self-explanation.
  
  
  METHODS
  In a previous study, 36 third-year medical students diagnosed familiar and less familiar clinical cases either by engaging in self-explanation or not. Based on an analysis of previously collected data, the present study compared the content of self-explanation protocols generated by seven randomly selected students while solving four familiar and four less familiar cases. In total, 56 verbal protocols (28 familiar and 28 less familiar) were segmented and coded using the following categories: paraphrases, biomedical inferences, clinical inferences, monitoring statements and errors.
  
  
  RESULTS
  Students provided more self-explanation segments from less familiar cases (M = 275.29) than from familiar cases (M = 248.71, p = 0.046). They provided significantly more paraphrases (p = 0.001) and made more errors (p = 0.008). A significant interaction was found between familiarity and the type of inferences (biomedical versus clinical, p = 0.016). When self-explaining less familiar cases, students provided significantly more biomedical inferences than familiar cases.
  
  
  CONCLUSIONS
  Lack of familiarity with a case seems to stimulate medical students to engage in more extensive thinking during self-explanation. Less familiar cases seem to activate students' biomedical knowledge, which in turn helps them to create new links between biomedical and clinical knowledge, and eventually construct a more coherent mental representation of diseases. This may clarify the previously found positive effect that self-explanation has on the diagnosis of unfamiliar cases.
authors.affiliation: Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Martine
authors.initials: M
authors.lastname: Chamberland
authors.forename: Sílvia
authors.initials: S
authors.lastname: Mamede
authors.forename: Christina
authors.initials: C
authors.lastname: St-Onge
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Rivard
authors.forename: Jean
authors.initials: J
authors.lastname: Setrakian
authors.forename: Annie
authors.initials: A
authors.lastname: Lévesque
authors.forename: Luc
authors.initials: L
authors.lastname: Lanthier
authors.forename: Henk G
authors.initials: HG
authors.lastname: Schmidt
authors.forename: Remy M J P
authors.initials: RM
authors.lastname: Rikers
mesh_terms: D004504:Education, Medical, Undergraduate / Q000379:methods*; D006801:Humans; D019359:Knowledge; D007858:Learning; D011340:Problem Solving; D018794:Problem-Based Learning / Q000379:methods*; D013337:Students, Medical / Q000523:psychology*