title: High-risk human papilloma virus management in pregnancy with cervical intraepithelial neoplasia during pregnancy and postpartum in China.
abstract: OBJECTIVE
  To investigate the relationship between cervical intraepithelial neoplasia (CIN) and high-risk human papilloma virus (HR-HPV) during pregnancy and postpartum in China.
  
  
  METHODS
  In this prospective case-control study, 168 pregnant women with CIN and cervicitis were diagnosed by colposcopic cervical biopsy. All the cases underwent hybrid capture assay version II (HCII) to detect HR-HPV DNA load amounts and the tests were completed in 3-6 months after childbirth.
  
  
  RESULTS
  During pregnancy: as the CIN grade increased, the HR-HPV infection rates increased (P = 0.002), but HR-HPV DNA load amounts (in logarithms) did not change obviously (P = 0.719). 3-6 months postpartum: as the CIN grade increased, the natural negative rate of HR-HPV decreased (P = 0.000), while the amount of HR-HPV DNA (in logarithms) increased (P = 0.036); especially the amount of HR-HPV DNA in pregnant women with CINIII was significantly higher than that of other grades. During pregnancy and 3-6 months postpartum : the amount of HR-HPV DNA (in logarithms) during pregnancy was higher than that of 3-6 months postpartum with the same grade of CIN.
  
  
  CONCLUSIONS
  The findings emphasize the importance of undergoing the HCII test 3-6 months postpartum. It should be noted that HR-HPV may turn negative in pregnancy with CINIII 3-6 months after childbirth. Further treatments of pregnancy with CIN should be considered according to the CIN grade diagnosed by cervical biopsy via colposcopy 3-6 months after birth, but not according to the persistence of HR-HPV during pregnancy.
authors.affiliation: Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: He
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Wu
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Song
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000821:virology*; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000821:virology*; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology / Q000821:virology*; D002575:Uterine Cervicitis / Q000821:virology; D019562:Viral Load; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000737:chemistry / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral
keywords: cervical intraepithelial neoplasia; human papilloma virus; pregnancy