title: Simultaneous determination of dopamine, sertonin and ascorbic acid at a glassy carbon electrode modified with carbon-spheres.
abstract: A novel glassy carbon electrode (GCE) modiﬁed with carbon-spheres has been fabricated through a simple casting procedure. The modified GCE displays high selectivity and excellent electrochemical catalytic activities towards dopamine (DA), serotonin (5-HT), and ascorbic acid (AA). In the co-existence system, the peak separations between AA and DA, DA and 5-HT, and AA and 5-HT are large up to 230, 180, and 410 mV, respectively. Differential pulse voltammetry (DPV) has been employed to simultaneously detect DA, 5-HT, and AA, and the linear calibration curves for DA, 5-HT, and AA are obtained in the range of 20.0-150.0 μM, 40.0-750.0 μM and 300.0-2,000.0 μM with detection limits (S/N = 3) of 2.0 μM, 0.7 μM and 0.6 μM, respectively. The proposed electrode has been applied to detect DA, 5-HT, and AA in real samples using standard addition method with satisfactory results.
authors.affiliation: Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Key Laboratory of Chemo/Biosensing, Anhui Province, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China,. fgao@mail.ahnu.edu.cn.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Zhou
authors.forename: Meili
authors.initials: M
authors.lastname: Sheng
authors.forename: Xueyue
authors.initials: X
authors.lastname: Jiang
authors.forename: Guozhi
authors.initials: G
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D002244:Carbon / Q000737:chemistry*; D045424:Complex Mixtures / Q000032:analysis; D003217:Conductometry / Q000295:instrumentation*; D004298:Dopamine / Q000032:analysis*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005898:Glass / Q000737:chemistry; D008832:Microchemistry / Q000295:instrumentation; D008863:Microspheres; D012701:Serotonin / Q000032:analysis*
chemical_list: D045424:Complex Mixtures; D012701:Serotonin; D002244:Carbon; D001205:Ascorbic Acid; D004298:Dopamine