title: Primary bone lymphoma with multiple vertebral involvement.
abstract: A 20-year-old student presented with 2 months history of fever and night sweats, 15 days history of low backache, progressive weakness of both limbs of 7 days duration, and urinary retention for last 24 h. Examination revealed a sensory level at D 10 dermatome and grade two power in both the lower limbs with absent reflexes. Examination of spine revealed a knuckle at T8 level, which was tender on palpation. MRI spine showed erosion of D11-12 and L1 in vertebral bodies with destruction of left pedicles, transverse processes and lamina, and a prominent psoas abscess. Post gadolinium study revealed ring-enhancing lesions in the D11-12 and L1 vertebrae as well as the dural sac. Fine needle aspiration cytology (FNAC) and bone biopsy demonstrated a non-Hodgkin's lymphoma (NHL, large cell high-grade) of the spine (primary), which as per age is the youngest case of NHL ever reported in literature with multiple vertebral involvement.
authors.affiliation: Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Showkat Hussain
authors.initials: SH
authors.lastname: Dar
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Wazir
authors.forename: Ishrat Hussain
authors.initials: IH
authors.lastname: Dar
authors.forename: Jang Bahadur
authors.initials: JB
authors.lastname: Singh
mesh_terms: D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013131:Spine / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult