title: Evidence for central regulation of glucose metabolism.
abstract: Evidence for central regulation of glucose homeostasis is accumulating from both animal and human studies. Central nutrient and hormone sensing in the hypothalamus appears to coordinate regulation of whole body metabolism. Central signals activate ATP-sensitive potassium (KATP) channels, thereby down-regulating glucose production, likely through vagal efferent signals. Recent human studies are consistent with this hypothesis. The contributions of direct and central inputs to metabolic regulation are likely of comparable magnitude, with somewhat delayed central effects and more rapid peripheral effects. Understanding central regulation of glucose metabolism could promote the development of novel therapeutic approaches for such metabolic conditions as diabetes mellitus.
authors.affiliation: From the Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461.
authors.forename: Michelle
authors.initials: M
authors.lastname: Carey
authors.forename: Sylvia
authors.initials: S
authors.lastname: Kehlenbrink
authors.forename: Meredith
authors.initials: M
authors.lastname: Hawkins
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D054086:KATP Channels / Q000378:metabolism; D008954:Models, Biological; D009752:Nutritional Status; D015398:Signal Transduction
chemical_list: D005227:Fatty Acids; D007328:Insulin; D054086:KATP Channels; D005947:Glucose
keywords: Brain; Central Nervous System; Glucose Metabolism; Hypothalamus; Insulin; Lipid Metabolism