title: High-resolution MRI of uveal melanoma using a microcoil phased array at 7 T.
abstract: High-field MRI is a promising technique for the characterisation of ocular tumours, both in vivo and after enucleation. For in vivo imaging at 7 T, a dedicated three-element microcoil array was constructed as a high-sensitivity receive-only device. Using a dedicated blink/fixation protocol, high-resolution in vivo images could be acquired within 3 min in volunteers and patients with no requirement for post-acquisition image registration. Quantitative measures of axial length, aqueous depth and lens thickness in a healthy volunteer were found to agree well with standard ocular biometric techniques. In a patient with uveal melanoma, in vivo MRI gave excellent tumour/aqueous body contrast. Ex vivo imaging of the enucleated eye showed significant heterogeneity within the tumour.
authors.affiliation: C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: J W M
authors.initials: JW
authors.lastname: Beenakker
authors.forename: G A
authors.initials: GA
authors.lastname: van Rijn
authors.forename: G P M
authors.initials: GP
authors.lastname: Luyten
authors.forename: A G
authors.initials: AG
authors.lastname: Webb
mesh_terms: D016477:Artifacts; D016022:Case-Control Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology*; D009038:Motion; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D000098943:Uveal Melanoma
keywords: high-resolution ocular MRI; microcoil array; motion suppression; optical biometry; uveal melanoma