title: Effect of ethanolic extract of leaves of Paederia foetida Linn. on acetic acid induced colitis in albino rats.
abstract: OBJECTIVE
  To evaluate the effect of ethanolic extract of leaves of Paederia foetida on acetic acid induced colitis in albino rats.
  
  
  METHODS
  Ethanolic extract of Paederia foetida (EEPF) was prepared by percolation method. Acute toxicity test was done by using Organization for Economic Cooperation and Development guidelines. Albino rats were divided into four groups of five animals each. Groups A and B received 3% gum acacia. Groups C and D received EEPF 500 mg/kg body weight (BW) and 5-aminosalisylic acid 100 mg/kg BW respectively. Colitis was induced by transrectal administration of 4% acetic acid on 5(th) day. All animals were sacrificed after 48 h of colitis induction and distal 10 cm of the colon was dissected. Colon was weighed for disease activity index (DAI) and scored macroscopically and microscopically. Biochemical assessment of tissue myeloperoxidase (MPO), catalase (CAT) and superoxide dismutase (SOD) was done in colonic tissue homogenate and malondialdehyde (MDA) was estimated in serum.
  
  
  RESULTS
  P. foetida showed significant (P < 0.05) reduction in DAI, macroscopic and microscopic lesion score as well as significant (P < 0.05) improvement in MPO, MDA, CAT, and SOD level as compared to Group B.
  
  
  CONCLUSIONS
  The ethanolic extract of leaves of P. foetida showed significant amelioration of experimentally induced colitis, which may be attributed to its anti-inflammatory and antioxidant property.
authors.affiliation: Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh, Assam, India.
authors.forename: Swarnamoni
authors.initials: S
authors.lastname: Das
authors.forename: Lalit
authors.initials: L
authors.lastname: Kanodia
authors.forename: Apurba
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Abdul
authors.initials: A
authors.lastname: Hakim
mesh_terms: D019342:Acetic Acid / Q000633:toxicity*; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry*; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D000431:Ethanol; D019342:Acetic Acid
keywords: Antioxidant; Paederia foetida; colitis