title: Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model.
abstract: The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheuma-toid arthritis.
authors.affiliation: R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center, Golden Helix, Seoul 151-742.
authors.forename: Jong Bae
authors.initials: JB
authors.lastname: Seo
authors.forename: Jae-Yeon
authors.initials: JY
authors.lastname: Jeong
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Park
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Jun
authors.forename: Sang-Ik
authors.initials: SI
authors.lastname: Lee
authors.forename: Sung Sik
authors.initials: SS
authors.lastname: Choe
authors.forename: Do-Yang
authors.initials: DY
authors.lastname: Park
authors.forename: Eun-Wook
authors.initials: EW
authors.lastname: Choi
authors.forename: Dong-Seung
authors.initials: DS
authors.lastname: Seen
authors.forename: Jong-Soon
authors.initials: JS
authors.lastname: Lim
authors.forename: Tae Gyu
authors.initials: TG
authors.lastname: Lee
keywords: Analgesic; Anti-inflammatory; Arthritis; Pain; Terminalia chebula