title: A genome-wide association study of severe teenage acne in European Americans.
abstract: Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 × 10(-6)). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies.
authors.affiliation: Department of Dermatology, Clinical Research Program, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Zhang
authors.forename: Abrar A
authors.initials: AA
authors.lastname: Qureshi
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: Jiali
authors.initials: J
authors.lastname: Han
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology* / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000483:Alleles; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011786:Quality Control; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D005819:Genetic Markers