title: Antidepressants for neuro-regeneration: from depression to Alzheimer's disease.
abstract: Recently identified new potential functions of antidepressants in the treatment of neurodegenerative will be introduced. Antidepressants are reported to regulate stem cell fate to regenerate neurons in the adult hippocampus and are effective in reducing toxic amyloid peptides and are known to increase neurotrophic factor such as brain-derived neurotrophic factor. Clinical trial data support that antidepressants have potential to treat Alzheimer's disease.
authors.affiliation: Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea, hyunjungkim@cau.ac.kr.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Woosuk
authors.initials: W
authors.lastname: Kim
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kong
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003863:Depression / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor