title: Accurate detection of metabolically active "brown" and "white" adipose tissues with computed tomography.
abstract: BACKGROUND
  Adipose tissues (AT) are highly metabolically active complex endocrine organs and are classified into white (WAT) and brown AT (BAT) with proinflammatory and anti-inflammatory characteristics. The current study investigated the accuracy of computed tomography (CT) to quantitatively detect BAT and WAT based on Hounsfield unit (HU) threshold compared to standardized uptake values (SUVs) of corresponding AT with the use of positron emission tomography (PET).
  
  
  METHODS
  One hundred twenty-four patients who underwent whole-body (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT were studied. The SUVs and HUs of regions of BAT and WAT were measured and compared in these scans. The receiver operator characteristic (ROC) analysis was used to detect the HU threshold values for the detection of BAT and WAT.
  
  
  RESULTS
  The CT HU of BAT, with high (18)F-FDG uptake, was significantly higher compared to WAT (-67.1 ± 8.2 [-10 to -87] versus -93.5 ± 10.1 [-88 to -190], P = .0006). Generalized linear-regression models revealed that mean CT HU of BAT was 26.4 HU higher than that of WAT (P = .001). A strong agreement between CT HU and PET SUV in measuring metabolically active AT (r(2) = 0.81, P = .0001) was observed. The ROC curve showed that the optimal cutoff value of CT HU to detect BAT was HU ≥-87 with sensitivity of 83.3% and specificity of 100%, and the negative CT HU below -87 is highly specific for WAT.
  
  
  CONCLUSIONS
  In our study, CT can accurately and quantitatively detect BAT and WAT based on CT HU threshold, which is -10 to -87 for BAT and -88 to -190 for WAT.
authors.affiliation: Greater Los Angeles Veterans Administration Medical Center, UCLA-School of Medicine, 11301 Wilshire Blvd, Cardiology Section, Los Angeles, CA 90073; Captain James Lovell Federal Health Care Center, Chicago Medical School, North Chicago, IL. Electronic address: drnaserahmadi@gmail.com.
authors.forename: Naser
authors.initials: N
authors.lastname: Ahmadi
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Hajsadeghi
authors.forename: Mark
authors.initials: M
authors.lastname: Conneely
authors.forename: Mark
authors.initials: M
authors.lastname: Mingos
authors.forename: Rohit
authors.initials: R
authors.lastname: Arora
authors.forename: Matthew
authors.initials: M
authors.lastname: Budoff
authors.forename: Ramin
authors.initials: R
authors.lastname: Ebrahimi
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging*; D052436:Adipose Tissue, White / Q000000981:diagnostic imaging*; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Brown adipose tissue; Hounsfield units; computed tomography; positron emission tomography; standard uptake value; white adipose tissue