title: Therapeutic drug monitoring to assess clinical response to sedative medications in the intensive care unit: a case report and discussion.
abstract: We describe the pharmacological evaluation of a 60 year old female admitted to the intensive care unit with severe necrotizing fasciitis not responding to excessive dosages of intravenous sedatives and analgesics. This evaluation revealed the first to be reported midazolam-ketamine drug interaction in the medical literature and explains how we were able to answer a relevant clinical question using pharmacokinetics and pharmacodynamics analysis of serum drug levels.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mosli
authors.forename: Daniel
authors.initials: D
authors.lastname: Ovakim
authors.forename: Rommel
authors.initials: R
authors.lastname: Tirona
authors.forename: George
authors.initials: G
authors.lastname: Dresser
authors.forename: Bandar
authors.initials: B
authors.lastname: Al-Judaibi
mesh_terms: D004347:Drug Interactions / Q000502:physiology; D016903:Drug Monitoring / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000097:blood; D007362:Intensive Care Units / Q000592:standards; D007649:Ketamine / Q000009:adverse effects* / Q000097:blood; D008874:Midazolam / Q000009:adverse effects* / Q000097:blood; D008875:Middle Aged
chemical_list: D006993:Hypnotics and Sedatives; D007649:Ketamine; D008874:Midazolam