title: The effect of treadmill running on memory before and after the NBM-lesion in rats.
abstract: Some studies have shown the effects of exercise training in retarding onset and progression of memory deficit in neurodegenerative disorders such as Alzheimer's disease. In this research, we investigated the effect of treadmill running on memory function; before, after, and continually (before and after) the nucleus basalis magnocellularis lesions. 66 male rats were randomly divided into six groups, including control, sham operation, the NBM-lesion, exercise before the NBM-lesion, exercise after the NBM-lesion, and exercise before and after the NBM-lesion. Lesion was induced by 5 μg/μl bilateral injection of Ibotenic acid. Memory function was assessed by using the passive avoidance learning test. Our results showed that treadmill running delays cognitive decline in the NBM-lesion rats, prevented memory deficit, and has advantageous effects on short-term, intermediate and long-term memory. Exercising on a regular basis may impede memory loss significantly, which may be attributed to specific molecular pathways in the brain.
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Hosseini
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.forename: Parham
authors.initials: P
authors.lastname: Reisi
authors.forename: Maryam
authors.initials: M
authors.lastname: Radahmadi
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D020532:Basal Nucleus of Meynert / Q000503:physiopathology*; D003072:Cognition Disorders / Q000534:rehabilitation*; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D007051:Ibotenic Acid / Q000494:pharmacology; D008297:Male; D008568:Memory; D051381:Rats; D017208:Rats, Wistar; D012420:Running
chemical_list: D007051:Ibotenic Acid
keywords: Memory; Nucleus basalis magnocellularis; Passive avoidance learning; Treadmill running