title: Mechanisms of hemostimulating effect of Aconitum baicalense diterpene alkaloids.
abstract: A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; National Research Irkutsk State Technical University, Russia. zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'eva
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: A V
authors.initials: AV
authors.lastname: Krapivin
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: A A
authors.initials: AA
authors.lastname: Semenov
authors.forename: D V
authors.initials: DV
authors.lastname: Reykhart
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D060833:Cellular Microenvironment; D004224:Diterpenes / Q000032:analysis / Q000494:pharmacology*; D005472:Fluorouracil; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D044968:Regenerative Medicine / Q000379:methods*
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D005472:Fluorouracil