title: A folding transition underlies the emergence of membrane affinity in amyloid-β.
abstract: Small amyloid-β (Aβ) oligomers have much higher membrane affinity compared to the monomers, but the structural origin of this functional change is not understood. We show that as monomers assemble into small n-mers (n < 10), Aβ acquires a tertiary fold that is consistent with the mature fibrils. This is an early and defining transition for the aggregating peptide, and possibly underpins its altered bioactivity.
authors.affiliation: Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India. maiti@tifr.res.in.
authors.forename: Suman
authors.initials: S
authors.lastname: Nag
authors.forename: Bidyut
authors.initials: B
authors.lastname: Sarkar
authors.forename: Muralidharan
authors.initials: M
authors.lastname: Chandrakesan
authors.forename: Rajiv
authors.initials: R
authors.lastname: Abhyanakar
authors.forename: Debanjan
authors.initials: D
authors.lastname: Bhowmik
authors.forename: Mamata
authors.initials: M
authors.lastname: Kombrabail
authors.forename: Sucheta
authors.initials: S
authors.lastname: Dandekar
authors.forename: Eitan
authors.initials: E
authors.lastname: Lerner
authors.forename: Elisha
authors.initials: E
authors.lastname: Haas
authors.forename: Sudipta
authors.initials: S
authors.lastname: Maiti
mesh_terms: D016229:Amyloid beta-Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D019793:Fluorescein / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry; D017510:Protein Folding; D017433:Protein Structure, Secondary
chemical_list: C496906:1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholine; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010713:Phosphatidylcholines; C078592:amyloid beta-protein (1-40); D019793:Fluorescein