title: Postprandial effects of potassium supplementation on vascular function and blood pressure: a randomised cross-over study.
abstract: OBJECTIVE
  Endothelial dysfunction, as assessed by flow mediated dilatation (FMD) is an early event in atherosclerosis and an independent predictor of cardiovascular events. The effect of potassium supplementation on endothelial function and blood pressure (BP) in the postprandial state is not known. The aim of this study was to assess endothelial function using FMD in healthy volunteers.
  
  
  RESULTS
  Thirty-two normotensive volunteers received a meal with 36 mmol potassium (High K) and a control 6 mmol potassium (Low K) meal on 2 separate occasions in a randomized order. FMD and BP were measured while participants were fasting and at 30, 60, 90 and 120 min after the meal. There was a postprandial decrease in FMD in both groups. FMD decreased overall less after the High K meal compared to the Low K meal (meal effect p < 0.05). Both meals produced a postprandial decrease in BP at 30 min which returned to baseline levels by 120 min. No significant differences in BP were observed between meals. FMD and systolic BP were negatively correlated at 90 (r = -0.54-0.55, p < 0.01) and 120 min (r = -0.42-0.56, p < 0.01) after both meals.
  
  
  CONCLUSIONS
  A high potassium meal, which contains a similar amount of potassium as 2.5 serves of bananas, can lessen the postprandial reduction in brachial artery FMD when compared to a low potassium meal.
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, GPO Box 2471, Adelaide, SA 5000, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Blanch
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, GPO Box 2471, Adelaide, SA 5000, Australia.
authors.forename: P M
authors.initials: PM
authors.lastname: Clifton
authors.affiliation: School of Pharmacy and Medical Science, University of South Australia, GPO Box 2471, Adelaide, SA 5000, Australia. Electronic address: Jennifer.Keogh@unisa.edu.au.
authors.forename: J B
authors.initials: JB
authors.lastname: Keogh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D001916:Brachial Artery / Q000187:drug effects; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D062407:Meals; D008875:Middle Aged; D019518:Postprandial Period; D017419:Potassium, Dietary / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D017419:Potassium, Dietary
keywords: Blood pressure; Endothelial function; Potassium