title: High serum osteopontin levels are associated with low bone mineral density in postmenopausal women.
abstract: Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n=32) and postmenopausal women (n=409) participated in the study. We measured serum osteopontin levels and their relationships with bone mineral density and previous total fragility fractures. The postmenopausal women had higher mean serum OPN levels compared to the premenopausal women (43.6±25.9 vs 26.3±18.6 ng/mL; P<0.001). In the postmenopausal women, high serum OPN levels were negatively correlated with mean lumbar bone mineral density (BMD) (r=-0.113, P=0.023). In a stepwise multiple linear regression model, serum OPN levels were associated with BMD of the spine, femoral neck, and total hip after adjustment for age, body mass index, smoking, and physical activity in postmenopausal women. However, serum OPN levels did not differ between postmenopausal women with and without fractures. Postmenopausal women exhibit higher serum OPN levels than premenopausal women and higher serum OPN levels were associated with low BMD in postmenopausal women.
authors.affiliation: Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Cho
authors.forename: Keun-Hyok
authors.initials: KH
authors.lastname: Cho
authors.forename: Hyang Ah
authors.initials: HA
authors.lastname: Lee
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000368:Aged; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D050723:Fractures, Bone / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D017698:Postmenopause; D017697:Premenopause; D013131:Spine / Q000378:metabolism
chemical_list: D053495:Osteopontin
keywords: Bone Mineral Density; Fragility Fracture; Postmenopause; Serum Osteopontin Levels