title: Cerebrospinal fluid penetration of tigecycline.
abstract: We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC(0-12) ratio was 0.067.
authors.affiliation: From the Infectious Diseases Clinic, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, "Santa Maria della Misericordia" Hospital , Perugia.
authors.forename: Carlo
authors.initials: C
authors.lastname: Pallotto
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fiorio
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Avolio
authors.forename: Alessio
authors.initials: A
authors.lastname: Sgrelli
authors.forename: Franco
authors.initials: F
authors.lastname: Baldelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
authors.forename: Giuseppe Vittorio
authors.initials: GV
authors.lastname: De Socio
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D005260:Female; D006801:Humans; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010949:Plasma / Q000737:chemistry; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline