title: HIV trafficking in host cells: motors wanted!
abstract: Throughout the viral replication cycle, viral proteins, complexes, and particles need to be transported within host cells. These transport events are dependent on the host cell cytoskeleton and molecular motors. However, the mechanisms by which virus is trafficked along cytoskeleton filaments and how molecular motors are recruited and regulated to guarantee successful integration of the viral genome and production of new viruses has only recently begun to be understood. Recent studies on HIV have identified specific molecular motors involved in the trafficking of these viral particles. Here we review recent literature on the transport of HIV components in the cell, provide evidence for the identity and role of molecular motors in this process, and highlight how these trafficking events may be related to those occurring with other viruses.
authors.affiliation: Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France; INSERM, U932, 26 rue d'Ulm, 75248 Paris Cedex 05, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Gaudin
authors.forename: Bruna Cunha
authors.initials: BC
authors.lastname: de Alencar
authors.forename: Nathalie
authors.initials: N
authors.lastname: Arhel
authors.forename: Philippe
authors.initials: P
authors.lastname: Benaroch
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism / Q000821:virology; D002477:Cells / Q000378:metabolism / Q000821:virology*; D006678:HIV / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism*
chemical_list: D020409:Molecular Motor Proteins
keywords: actin; cytoskeleton; dynein; kinesin; microtubule; myosin; retrovirus