title: Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum.
abstract: (+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3'-C-7' axis. Biological evaluation showed that (+)-lingzhiol or (-)-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-β1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , 132 Lanhei Road, Kunming 650201, P. R. China , Division of Nephrology, Nanfang Hospital, Southern Medical University, Key Laboratory for Organ Failure Research, Education Ministry , Guangzhou 510515, P. R. China , University of Chinese Academy of Sciences , Yuquan Road 19, Beijing 100049, P. R. China , and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong SAR, P. R. China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Ai
authors.forename: Li Li
authors.initials: LL
authors.lastname: Zhou
authors.forename: Arthur C K
authors.initials: AC
authors.lastname: Chung
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Ping
authors.initials: P
authors.lastname: Fang
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Qun
authors.initials: Q
authors.lastname: Hu
authors.forename: Fan-Fan
authors.initials: FF
authors.lastname: Hou
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D050527:Mesangial Cells / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010766:Phosphorylation; D051381:Rats; D020940:Reishi / Q000737:chemistry* / Q000378:metabolism; D051900:Smad3 Protein / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry*; D053773:Transforming Growth Factor beta1 / Q000737:chemistry* / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D051900:Smad3 Protein; D013729:Terpenes; D053773:Transforming Growth Factor beta1; C587942:lingzhiol