title: PIAS3 may represent a potential biomarker for diagnosis and therapeutic of human colorectal cancer.
abstract: Colorectal cancer (CRC) is a challenging problem both for the developed and underdeveloped countries. Despite numerous improvements in early diagnosis and treatment, the incidence and mortality is still keeping in a high level. Molecule targeted therapy has drawn much attention as next generation anticancer agents for diagnosis and therapeutic of CRC. Protein Inhibitor of Activated Signal Transducer and Activators of Transcription 3 (PIAS3) as a novel biomarker has been focused to have a role in the development of malignancy, which was expressed at a higher level in most common malignancies compared with corresponding normal tissues. Furthermore, evidences suggest that the expression of PIAS3 can affect the growth of cancer cells by inhibiting the JAK/STAT and PI3-K/Akt signaling pathways or regulating its SUMO (small-ubiquitin like modifiers) ligase activity in some malignancy. Therefore, we hypothesized that PIAS3 may be a potential biomarker target for early cancer detection and therapeutic of human CRC.
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital to Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Gao
authors.forename: Sunil Man
authors.initials: SM
authors.lastname: Bijukchhe
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D050828:Protein Inhibitors of Activated STAT / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018832:Molecular Chaperones; C484745:PIAS3 protein, human; D050828:Protein Inhibitors of Activated STAT; D025841:Small Ubiquitin-Related Modifier Proteins