title: Determination of periodontopathogens in patients with Cri du chat syndrome.
abstract: OBJECTIVE
  Cri du chat syndrome is a genetic alteration associated with some oral pathologies. However, it has not been described previously any clinical relationship between the periodontal disease and the syndrome. The purpose of this comparative study was to compare periodontopathogenic flora in a group with Cri du chat syndrome and another without the síndrome, to assess a potential microbiological predisposition to suffer a periodontitis.
  
  
  METHODS
  The study compared nineteen subjects with Cri du chat Syndrome with a control group of nineteen patients without it. All patients were clinically evaluated by periodontal probing, valuing the pocket depth, the clinical attachmente level and bleeding on probing. There were no significant differences between both groups. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola were detected by multiplex-PCR using 16S rDNA (microIDENT).
  
  
  RESULTS
  When A. actinomycetemcomitans, P. gingivalis, P. intermedia and T. denticola were compared, no statistically significant differences were found between the two groups (p>0.05). The value of T. forsythia was significantly higher for Cri du chat syndrome (31.6%) than for the control group (5.3%). The odds ratio for T. forsythia was 8.3.
  
  
  CONCLUSIONS
  In the present study T. forsythia is associated with Cri du chat syndrome subjects and not with healthy subjects.
authors.affiliation: School of Dentistry of Sevilla c/ Avicena s/n 41009, Sevilla. Spain, gmachuca@us.es.
authors.forename: Sofía
authors.initials: S
authors.lastname: Ballesta-Mudarra
authors.forename: Guillermo
authors.initials: G
authors.lastname: Machuca-Portillo
authors.forename: Daniel
authors.initials: D
authors.lastname: Torres-Lagares
authors.forename: Ángela
authors.initials: Á
authors.lastname: Rodríguez-Caballero
authors.forename: Rosa-María
authors.initials: RM
authors.lastname: Yáñez-Vico
authors.forename: Enrique
authors.initials: E
authors.lastname: Solano-Reina
authors.forename: Evelio
authors.initials: E
authors.lastname: Perea-Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003410:Cri-du-Chat Syndrome / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D010514:Periodontal Pocket / Q000382:microbiology*; D055815:Young Adult