title: Antidepressant, psychostimulant, and nootropic effects of major and trace element composition.
abstract: The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilization time in the Porsolt test and promote retention of the conditioned passive avoidance. The most pronounced psychostimulant effect of the substance was observed at a dose of 4.68 mg/kg and the most pronounced antidepressant effect was found at a dose of 18.72 mg/kg. Maximum nootropic activity of the preparation was found at a dose of 93.6 mg/kg.
authors.affiliation: Laboratory of Phytopharmacology, Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. olgaafanasjeva@mail.ru.
authors.forename: O G
authors.initials: OG
authors.lastname: Afanasieva
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: I V
authors.initials: IV
authors.lastname: Shilova
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects; D003863:Depression / Q000188:drug therapy*; D008278:Magnesium Sulfate / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D012413:Rubidium / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology*; D019287:Zinc Sulfate / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D018697:Nootropic Agents; D014131:Trace Elements; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D019287:Zinc Sulfate; D012413:Rubidium