title: Allogeneic stem cell transplantation in patients with aggressive primary cutaneous T-cell lymphoma - a case series of the ADF working group "cutaneous lymphomas".
abstract: BACKGROUND
  Allogeneic stem cell transplantation (alloSCT) is a treatment option for primary cutaneous T-cell lymphomas that may induce long-lasting complete remissions. Little information is available on safety and efficacy.
  
  
  METHODS
  We retrospectively reviewed the data from patients with primary cutaneous T-cell lymphoma treated in the Departments of Dermatology of the Universities of Bochum, Mannheim and Cologne who received subsequent alloSCT between 2005 and 2012.
  
  
  RESULTS
  Nine patients with aggressive primary cutaneous T-cell-lymphoma received alloSCT. With a follow-up of 14 to 36 months after transplantation, 4 patients are alive and in complete remission. Two patients had recurrent disease post-transplantation, which was successfully treated with donor lymphocyte infusions. Non-relapse mortality was observed in three patients in advanced disease stages within six months after alloSCT. One patient showed only partial remission and died of disease after 32 months and one patient died 26 months after alloSCT with cause of death unknown.
  
  
  CONCLUSIONS
  This report documents the possible benefit of a graft-versus-lymphoma effect in primary cutaneous T-cell lymphoma, as has been observed for other T-cell malignancies and emphasizes that alloSCT warrants further studies in this setting.
authors.affiliation: Department of Dermatology, Ruhr- University Bochum.
authors.forename: Rose K C
authors.initials: RK
authors.lastname: Moritz
authors.forename: Markus
authors.initials: M
authors.lastname: Ditschkowski
authors.forename: Claus-Detlev
authors.initials: CD
authors.lastname: Klemke
authors.forename: Sarah
authors.initials: S
authors.lastname: Terras
authors.forename: Max
authors.initials: M
authors.lastname: Schlaak
authors.forename: Martin
authors.initials: M
authors.lastname: Knorr
authors.forename: Sebastian
authors.initials: S
authors.lastname: Theurich
authors.forename: Ute
authors.initials: U
authors.lastname: Hegenbart
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kremens
authors.forename: Dietrich W
authors.initials: DW
authors.lastname: Beelen
authors.forename: Markus
authors.initials: M
authors.lastname: Stücker
authors.forename: Alexander
authors.initials: A
authors.lastname: Kreuter
mesh_terms: D000328:Adult; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome