title: Matrix metalloproteinase-1 promoter -1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta-analysis and systematic review.
abstract: OBJECTIVE
  Matrix metalloproteinase-1 promoter -1607 1G/2G (rs1799750) polymorphism have been shown to confer genetic susceptibility to chronic periodontitis (CP), but the results are inconsistent.
  
  
  METHODS
  A meta-analysis and systematic review was performed to accomplish a more precise estimation of the relationship.
  
  
  RESULTS
  Pooled estimates revealed that there was no significant association between this polymorphism and CP risk in Caucasian and Asian populations. In addition, it was reported by three Brazilian studies that no significant association was found for this polymorphism with CP risk in a Brazilian mixed population. Besides, there was no significant association of this polymorphism with mild to moderate and severe CP risk in both Caucasian and Asian populations. Moreover, both non-smokers and smokers did not have a significant association between this polymorphism and susceptibility to CP in Caucasian population.
  
  
  CONCLUSIONS
  Matrix metalloproteinase-1 promoter -1607 1G/2G (rs1799750) polymorphism may have no effect on the disease susceptibility of CP in Caucasian, Asian and Brazilian mixed populations. Besides, this polymorphism may not play a direct role in severity of CP among both Caucasian and Asian populations, and between this polymorphism and smoking there may be no interactions to be associated with CP risk in Caucasian population.
authors.affiliation: State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Wenyang
authors.initials: W
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
mesh_terms: D044466:Asian People / Q000235:genetics; D001938:Brazil / Q000208:ethnology; D055113:Chronic Periodontitis / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006147:Guanine; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D006147:Guanine; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
keywords: chronic periodontitis; matrix metalloproteinase-1; meta-analysis; polymorphism