title: [Radix hedysari extract promotes peripheral nerve regeneration].
abstract: Treatment of peripheral nerve injury is a major challenge in clinical practice. With advances in molecular biology and development of microsurgical techniques and tissue engineering, peripheral nerve repair procedures have been greatly improved. In the last 10 decades, most treatments for peripheral nerve injury in animal models have achieved histological and functional recovery, the treatments in humans, however, produce insufficient recovery, especially for proximal nerve injury. Increasing attention has been paid to the Traditional Chinese Medicine (TCM) for promoting peripheral nerve regeneration, since these remedies often display effective clinical outcome, minor side effects and effectiveness for multiple targets. Although TCM has complex ingredients and the specific pharmacological mechanisms for their effectiveness are still unclear, an effective clinical outcome is welcomed by many clinicians. In the past 20 years, we have made a series of detailed studies including the toxicity tests, pharmacodynamic tests, pharmacological experiments etc, about a new traditional formula which mainly contains the Radix hedysari, Epimedium etc. RESULTS have shown that this formula is safe to be used in both animals and humans with no toxicity and adverse effect, and systemic administration of this formula could enhance the peripheral nerve regeneration.
authors.affiliation: Department of Trauma and Orthopeadics, Peking University Peoples Hospital;Peking University Traffic Medicine Center, Beijing 100044, China.
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Kou
authors.forename: Pei-Xun
authors.initials: PX
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Dang
authors.forename: Shao-Yin
authors.initials: SY
authors.lastname: Wei
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wang
authors.forename: Dian-Ying
authors.initials: DY
authors.lastname: Zhang
authors.forename: Zhong-Guo
authors.initials: ZG
authors.lastname: Fu
authors.forename: Bao-Guo
authors.initials: BG
authors.lastname: Jiang
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D034181:Epimedium / Q000737:chemistry; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D059348:Peripheral Nerve Injuries / Q000188:drug therapy* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts