title: Intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis: review of animal models.
abstract: The development of suitable animal models is essential to experimental research on intraperitoneal chemotherapy (IPC). This review of the English literature (MEDLINE) presents a detailed analysis of current animal models and gives recommendations for future experimental research. Special consideration should be given to cytotoxic drug dose and concentration, tumor models, and outcome parameters.
authors.affiliation: Department of Surgery, Ghent University Hospital, Ghent, Belgium.
authors.forename: Félix
authors.initials: F
authors.lastname: Gremonprez
authors.forename: Wouter
authors.initials: W
authors.lastname: Willaert
authors.forename: Wim
authors.initials: W
authors.lastname: Ceelen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D004195:Disease Models, Animal; D006979:Hyperthermia, Induced / Q000379:methods; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents
keywords: HIPEC; animal experimentation; colorectal carcinoma; cytoreductive surgery; peritoneal metastasis