title: Nickel-catalyzed sonogashira reactions of non-activated secondary alkyl bromides and iodides.
abstract: A nicked reaction: The title reaction of terminal alkynes with non-activated secondary alkyl iodides and bromides was accomplished for the first time. This reaction provides a new and practical approach for the synthesis of substituted alkynes (see scheme; cod=cyclo-1,5-octadiene).
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084 (China); State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (China); Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).
authors.forename: Jun
authors.initials: J
authors.lastname: Yi
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D007454:Iodides / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001965:Bromides; D056831:Coordination Complexes; D007454:Iodides; D009532:Nickel
keywords: alkynes; cross-coupling; halides; nickel; synthetic methods