title: New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) and multiple sclerosis (MS) are autoimmune diseases with a close relationship to their disease pattern and immunologic cascade with considerable morbidity and mortality. This article provides insight of why tumor necrosis factor blockers couldn't work in multiple sclerosis and why interferon-beta doesn't work in inflammatory bowel disease. In this article, we provide a detailed review of the linkage and potential interchangeable medication between IBD and MS in addition to Natalizumab, Trichuris suis egg therapy and vitamin D. Different treatment strategies may have potential in treating both diseases in the future.
authors.affiliation: Department of Medicine, Department of Neurology and Division of Allergy Immunology, Nassau University Medical Center, East Meadow, NY, USA. Electronic address: clin1@numc.edu.
authors.forename: Chen Hsing
authors.initials: CH
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Kadakia
authors.forename: Marianne
authors.initials: M
authors.lastname: Frieri
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy*; D016899:Interferon-beta / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy*; D000069442:Natalizumab; D058504:Th17 Cells / Q000276:immunology; D014258:Trichuris; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000069442:Natalizumab; D014409:Tumor Necrosis Factor-alpha; D014807:Vitamin D; D016899:Interferon-beta
keywords: Blood brain barrier; Inflammatory bowel disease; Multiple sclerosis; Th17 cells