title: Serum leptin and 5-hydroxytryptamine measurements for the diagnosis and treatment of premature ejaculation.
abstract: OBJECTIVE
  To study the significance of measurements of plasma leptin and 5-hydroxytryptamine (5-HT) levels in the diagnosis of premature ejaculation (PE).
  
  
  METHODS
  We compared plasma leptin and 5-HT levels, intravaginal ejaculation latency time (IELT) and Chinese Index of Premature Ejaculation-5 (CIPE-5) scores between 59 patients with PE and 64 healthy control men without PE. We then analyzed the correlations of plasma leptin and 5-HT levels with the IELT and CIPE-5 scores. The patients with PE were administered sertraline (50mg daily) for 8 weeks, and their plasma leptin and 5-HT levels, CIPE-5 scores and IELT were measured again. Comparative analyses of the data were performed between the experimental and control groups and between the pre- and post-treatment values.
  
  
  RESULTS
  Plasma leptin levels were significantly higher (P <.0001), whereas plasma 5-HT levels (P <.0001), IELT (P <.0001), and CIPE-5 scores (P <.0001) were significantly lower in the experimental group than in the control group. Significant changes in leptin and 5-HT levels, IELT and CIPE-5 scores were observed after treatment in the experimental group. Plasma leptin levels negatively correlated with 5-HT levels, CIPE-5 scores, and IELT, whereas 5-HT levels positively correlated with IELT and CIPE-5 scores.
  
  
  CONCLUSIONS
  Plasma leptin and 5-HT levels indicate the presence of PE and can be used as diagnostic markers for PE.
authors.affiliation: Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Baolong
authors.initials: B
authors.lastname: Wang
authors.forename: Changhai
authors.initials: C
authors.lastname: Yang
authors.forename: Kunlong
authors.initials: K
authors.lastname: Tang
mesh_terms: D000328:Adult; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D061686:Premature Ejaculation / Q000175:diagnosis* / Q000628:therapy*; D012372:ROC Curve; D012701:Serotonin / Q000097:blood*; D055815:Young Adult
chemical_list: D020738:Leptin; D012701:Serotonin