title: Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting.
abstract: The purpose of this study was to histomorphometrically evaluate the percentage of vital bone after grafting of maxillary sinuses using two different concentrations of recombinant human bone morphogenetic protein/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and to compare the results to a control sinus grafted with MCBA only. Thirty-six sinuses in 18 patients had two of three of the graft combinations including: (1) control, MCBA only; (2) test one, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); or (3) test two, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). Histologic cores were taken 6 to 9 month following sinus augmentation. The results showed no statistically significant differences in vital bone between the two test groups compared to the control sinus group treated with MCBA alone. Future studies involving more cases and evaluating survival of implants placed in these augmented sinuses are needed to verify the results of this randomized prospective study.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Froum
authors.forename: Stephen
authors.initials: S
authors.lastname: Wallace
authors.forename: Sang-Choon
authors.initials: SC
authors.lastname: Cho
authors.forename: Ismael
authors.initials: I
authors.lastname: Khouly
authors.forename: Edwin
authors.initials: E
authors.lastname: Rosenberg
authors.forename: Patricia
authors.initials: P
authors.lastname: Corby
authors.forename: Scott
authors.initials: S
authors.lastname: Froum
authors.forename: Timothy
authors.initials: T
authors.lastname: Bromage
authors.forename: Robert
authors.initials: R
authors.lastname: Schoor
authors.forename: Robert
authors.initials: R
authors.lastname: Norman
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Tarnow
mesh_terms: D019072:Antibiotic Prophylaxis; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D016025:Bone Transplantation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D011994:Recombinant Proteins / Q000008:administration & dosage; D014184:Transplantation, Homologous
chemical_list: D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins