title: Antioxidant properties of pyrrolobenzimidazole derivative RU-792: experimental study.
abstract: We studied antioxidant activity of new derivative of pyrrolo[1,2-α]benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe(2+)-induced chemiluminescence of lipids with 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence.
authors.affiliation: Department of Pharmacology, Volgograd State Medical Academy; Laboratory of Pharmacology of Antioxidant Substances, Institute of Pharmacology, Volgograd State Medical Academy; Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia. vad-ak@mail.ru.
authors.forename: V A
authors.initials: VA
authors.lastname: Kosolapov
authors.forename: L V
authors.initials: LV
authors.lastname: Eltsova
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002839:Chromans / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D007700:Kinetics; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D001562:Benzimidazoles; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002839:Chromans; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D011758:Pyrroles; C000588689:RU-792; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid