title: Monitoring Hip and Elbow Dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA.
abstract: Hip (HD) and Elbow Dysplasia (ED) are two common complex developmental disorders of dogs. In order to decrease their prevalence and severity, the Orthopedic Foundation for Animals (OFA) has a voluntary registry of canine hip and elbow conformation certified by boarded radiologists. However, the voluntarily reports have been severely biased against exposing dogs with problems, especially at beginning period. Fluctuated by additional influential factors such as age, the published raw scores barely showed trends of improvement. In this study, we used multiple-trait mixed model to simultaneously adjust these factors and incorporate pedigree to derive Estimated Breeding Values (EBV). A total of 1,264,422 dogs from 74 breeds were evaluated for EBVs from 760,455 hip scores and 135,409 elbow scores. These EBVs have substantially recovered the reporting bias and the other influences. Clear and steady trends of genetic improvement were observed over the 40 years since 1970. The total genetic improvements were 16.4% and 1.1% of the phenotypic standard deviation for HD and ED, respectively. The incidences of dysplasia were 0.83% and 2.08%, and the heritabilities were estimated as 0.22 and 0.17 for hip and elbow scores, respectively. The genetic correlation between them was 0.12. We conclude that EBV is more effective than reporting raw phenotype. The weak genetic correlation suggested that selection based on hip scores would also slightly improve elbow scores but it is necessary to allocate effort toward improvement of elbow scores alone.
authors.affiliation: Key Laboratory of Agricultural Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, People's Republic of China ; Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, People's Republic of China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Hou
authors.forename: Yachun
authors.initials: Y
authors.lastname: Wang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Lu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Rory J
authors.initials: RJ
authors.lastname: Todhunter
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000818:Animals; D001947:Breeding; D004285:Dogs; D004551:Elbow Joint / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006619:Hip Dysplasia, Canine / Q000453:epidemiology* / Q000235:genetics*; D004204:Joint Dislocations / Q000151:congenital*; D008297:Male; D010641:Phenotype; D012737:Sex Factors