title: MHC-NP: predicting peptides naturally processed by the MHC.
abstract: We present MHC-NP, a tool for predicting peptides naturally processed by the MHC pathway. The method was part of the 2nd Machine Learning Competition in Immunology and yielded state-of-the-art accuracy for the prediction of peptides eluted from human HLA-A*02:01, HLA-B*07:02, HLA-B*35:01, HLA-B*44:03, HLA-B*53:01, HLA-B*57:01 and mouse H2-D(b) and H2-K(b) MHC molecules. We briefly explain the theory and motivations that have led to developing this tool. General applicability in the field of immunology and specifically epitope-based vaccine are expected. Our tool is freely available online and hosted by the Immune Epitope Database at http://tools.immuneepitope.org/mhcnp/.
authors.affiliation: Department of Computer Science and Software Engineering, Pavillon Adrien-Pouliot, 1065, av. De la Médecine, Université Laval, Québec, Québec, G1V 0A6, Canada. Electronic address: sebastien.giguere.8@ulaval.ca.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Giguère
authors.forename: Alexandre
authors.initials: A
authors.lastname: Drouin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lacoste
authors.forename: Mario
authors.initials: M
authors.lastname: Marchand
authors.forename: Jacques
authors.initials: J
authors.lastname: Corbeil
authors.forename: François
authors.initials: F
authors.lastname: Laviolette
mesh_terms: D000465:Algorithms; D000818:Animals; D017951:Antigen Presentation; D001185:Artificial Intelligence; D018604:Epitope Mapping / Q000379:methods*; D006183:H-2 Antigens / Q000737:chemistry / Q000276:immunology; D015789:HLA-A2 Antigen / Q000737:chemistry / Q000276:immunology; D015235:HLA-B Antigens / Q000737:chemistry / Q000276:immunology; D064532:Histocompatibility Antigen H-2D / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D010455:Peptides / Q000737:chemistry* / Q000276:immunology; D011485:Protein Binding; D012984:Software; D014612:Vaccines
chemical_list: D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; C435939:HLA-A*02:01 antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D064532:Histocompatibility Antigen H-2D; D010455:Peptides; D014612:Vaccines
keywords: Epitope; Immunology; Kernel; MHC; Machine learning; Vaccinology