title: Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling.
abstract: Plants and animals have evolved intracellular nucleotide-binding domain and leucine-rich repeat-containing immune receptors (NLRs) to perceive non-self and trigger immune responses. Plant NLRs detect strain-specific pathogen effectors and activate immune signaling leading to extensive transcriptional reprogramming and termination of pathogen infection. Here we review the recent findings in barley MLA immune receptor mediated immune responses against the barley powdery mildew fungus. We focus on nucleocytoplasmic partitioning of immune receptor, bifurcation of immune signaling, transcriptional repression and derepression connecting receptor activation to immune responses. We also discuss similar findings from other plant NLRs where appropriate.
authors.affiliation: State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China ; Graduate University of Chinese Academy of Sciences Beijing, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Qian-Hua
authors.initials: QH
authors.lastname: Shen
keywords: MLA; barley; cell death; immune signaling; plant NLRs; transcription factors; transcription regulation