title: Enantioselective liquid-liquid extraction of zopiclone with mandelic acid ester derivatives.
abstract: Enantioselective liquid-liquid extraction of zopiclone was conducted by employing a series of (R)-mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. (R)-o-chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum enantioselectivity of 1.6.
authors.affiliation: Department of Chemical Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Yangfeng
authors.initials: Y
authors.lastname: Peng
authors.forename: Quan
authors.initials: Q
authors.lastname: He
authors.forename: Bin
authors.initials: B
authors.lastname: Zuo
authors.forename: Haibo
authors.initials: H
authors.lastname: Niu
authors.forename: Tianzhong
authors.initials: T
authors.lastname: Tong
authors.forename: Hongliang
authors.initials: H
authors.lastname: Zhao
mesh_terms: D053961:Azabicyclo Compounds / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D059625:Liquid-Liquid Extraction; D008333:Mandelic Acids / Q000737:chemistry*; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D053961:Azabicyclo Compounds; D004952:Esters; D008333:Mandelic Acids; D010879:Piperazines; C515050:zopiclone; C037938:mandelic acid
keywords: chiral recognition; enantiomer; enantioselective extraction; mandelic acid ester; zopiclone