title: The role of impaired esophageal and gastric motility in end-stage lung diseases and after lung transplantation.
abstract: Today, many questions persist regarding the causal relationship of gastroesophageal reflux disease (GERD) to promote aspiration and its potential to induce both pulmonary and allograft failure. Current hypotheses, which have identified GERD as a nonimmune risk factor in inducing pulmonary and allograft failure, center on the role of GERD-induced aspiration of gastroduodenal contents. Risk factors of GERD, such as impaired esophageal and gastric motility, may indirectly play a role in the aspiration process. In fact, although impaired esophageal and gastric motility is not independently a cause of lung deterioration or allograft failure, they may cause and or exacerbate GERD. This report seeks to review present research on impaired esophageal and gastric motility in end-stage lung disease to characterize prevalence, etiology, pathophysiology, and current treatment options within this special patient population.
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, Illinois. Electronic address: pfisichella@lumc.edu.
authors.forename: Piero Marco
authors.initials: PM
authors.lastname: Fisichella
authors.forename: Anahita
authors.initials: A
authors.lastname: Jalilvand
mesh_terms: D003240:Connective Tissue Diseases / Q000209:etiology; D003550:Cystic Fibrosis / Q000209:etiology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000601:surgery; D005769:Gastrointestinal Motility; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000209:etiology; D014184:Transplantation, Homologous
keywords: Ambulatory pH monitoring; Aspiration; Esophageal motor dysfunction; Esophageal multichannel pH impedance; Gastric dysmotility; Gastroesophageal reflux disease (GERD); Lung transplantation