title: Eruptive melanocytic nevi induced by interferon for nodal metastatic melanoma: case report and review of the literature.
abstract: BACKGROUND
  The rapid appearance of multiple new melanocytic nevi is known as eruptive nevi and has been well documented to occur with certain medications, in particular chemotherapeutic agents.
  
  
  METHODS
  We report a case of a woman with melanoma complicated by nodal metastasis who developed multiple melanocytic nevi while on high-dose interferon.
  
  
  RESULTS
  Serial photographs confirmed that the pigmented lesions were of new onset, whereas histology documented that the lesions were dysplastic nevi. A survey of the literature documented numerous causes of eruptive nevi, which we review. To date, interferon has not been linked to eruptive nevi.
  
  
  CONCLUSIONS
  The phenomenon of eruptive nevi has been attributed to medications, bullous dermatoses, immunosuppression, and systemic conditions and is possibly a paraneoplastic disorder. Interferon appears to be another possible cause of this disorder.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Salopek
authors.forename: Muhammad N
authors.initials: MN
authors.lastname: Mahmood
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007372:Interferons / Q000009:adverse effects* / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D009508:Nevus, Pigmented / Q000139:chemically induced* / Q000175:diagnosis; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007372:Interferons