title: Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted byBeauveria bassianaCS1029.
abstract: The aim of this study was to investigate whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester produced by cell subtypeBeauveria bassianaCS1029 causes acute toxicity when used for cosmetic purposes by performing an eye irritation test. New Zealand white (NZW) rabbits were treated with a 100 mg/dose of S-(-)-10,11-dihydroxyfarnesic acid methyl ester according to standard procedure guidelines. No significant changes in terms of ocular lesions of the cornea, turbidity of the cornea, swelling of the eyelid or ocular discharge were observed in the methyl ester-treated groups, while sodium dioctyl sulfosuccinate, a positive control, caused severe toxicity. The anatomical and pathological observations indicate that the methyl ester produced byBeauveria bassianaCS1029 did not induce eye irritation in the lenses of the rabbits. The data suggest that the methyl ester evaluated in this study has promising potential as a cosmetic ingredient that does not irritate the eye.
authors.affiliation: Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Hyeong-U
authors.initials: HU
authors.lastname: Son
authors.forename: Sang-Han
authors.initials: SH
authors.lastname: Lee
keywords: Beauveria bassiana; cosmetic ingredient; dihydroxyfarnesic acid; eye irritation; toxicity