title: Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid.
abstract: Novel N-halamine-functionalized silica nanoparticles (NHFS NPs) were facilely fabricated from the 5-allylbarbituric acid (ABBA) by a seeded copolymerization using colloidal silica nanoparticles as support and ABBA-based N-halamine copolymers as shell. The NHFS NPs with spherical morphology and legible core-shell structure have the average diameter of 538.5 nm and the average shell thickness of 19.8 nm. The NHFS NPs possessed improved antimicrobial activity against both Gram-positive and Gram-negative bacteria compared with their bulk powder counterparts. The structural effect of N-halamine on bactericidal activity was clarified through the comparison between barbituric acid-based NHFS NPs and hydantoin-structural NHFS NPs. Effects of colloidal silica support and comonomer methyl methacrylate on particles morphology and the corresponding antimicrobial activity were comparatively investigated as well. Antibacterial tests revealed that N-halamine nanomaterials originated from barbituric acid derivative displayed powerful antibacterial performance and long-term stability.
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China. Electronic address: dongali@imu.edu.cn.
authors.forename: Alideertu
authors.initials: A
authors.lastname: Dong
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Xue
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Shi
authors.initials: S
authors.lastname: Lan
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.affiliation: College of Chemistry, Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Fengqi
authors.initials: F
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
authors.forename: Chokto
authors.initials: C
authors.lastname: Harnoode
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001463:Barbiturates / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001463:Barbiturates; D012822:Silicon Dioxide; C032232:barbituric acid
keywords: 5-Allylbarbituric acid; Bactericidal; Methyl methacrylate; N-Halamine; Silica