title: Clinical experimentation with aerosol antibiotics: current and future methods of administration.
abstract: Currently almost all antibiotics are administered by the intravenous route. Since several systems and situations require more efficient methods of administration, investigation and experimentation in drug design has produced local treatment modalities. Administration of antibiotics in aerosol form is one of the treatment methods of increasing interest. As the field of drug nanotechnology grows, new molecules have been produced and combined with aerosol production systems. In the current review, we discuss the efficiency of aerosol antibiotic studies along with aerosol production systems. The different parts of the aerosol antibiotic methodology are presented. Additionally, information regarding the drug molecules used is presented and future applications of this method are discussed.
authors.affiliation: Pulmonary Department, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kioumis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Porpodis
authors.forename: Dionysios
authors.initials: D
authors.lastname: Spyratos
authors.forename: Kosmas
authors.initials: K
authors.lastname: Tsakiridis
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: J Francis
authors.initials: JF
authors.lastname: Turner
authors.forename: Robert
authors.initials: R
authors.lastname: Browning
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hohenforst-Schmidt
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zarogoulidis
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D009330:Nebulizers and Vaporizers
chemical_list: D000336:Aerosols; D000900:Anti-Bacterial Agents
keywords: aerosol; antibiotics; nebulizers