title: Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model.
abstract: OBJECTIVE
  To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model.
  
  
  METHODS
  The Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O2:K1:H-) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group.
  
  
  RESULTS
  The use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05).
  
  
  CONCLUSIONS
  These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.
authors.affiliation: Department of Urology, International St Mary's Hospital, The Catholic Kwandong University of Korea, Incheon, Republic of Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Yoon
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Woong Jin
authors.initials: WJ
authors.lastname: Bae
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yong Sun
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: U Syn
authors.initials: US
authors.lastname: Ha
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Sung-Hoo
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Sohn
authors.affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ksw1227@catholic.ac.kr.
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Kim
mesh_terms: D061354:Acinar Cells / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000652:urine; D005355:Fibrosis; D007249:Inflammation / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011467:Prostate / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D011472:Prostatitis / Q000188:drug therapy* / Q000382:microbiology / Q000652:urine; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013025:Glycine max / Q000737:chemistry*; D014556:Urine / Q000382:microbiology
chemical_list: D000872:Anthocyanins; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts
keywords: anthocyanins; anti-bacterial agents; prostatitis