title: Systematic analysis of wide-field fundus autofluorescence (FAF) imaging in posterior uveitis.
abstract: OBJECTIVE
  To evaluate wide-field fundus autofluorescence (FAF) in patients with uveitis with retinal or chorioretinal involvement.
  
  
  METHODS
  We included 78 study eyes in this prospective study. Best-corrected visual acuity, a full clinical examination, wide-field green-light FAF and composite color, green and red laser separation fundus imaging with Optomap SLO were performed. In a systematic analysis, the number, extension and margins of central and peripheral retinal or chorioretinal alterations, scars and infiltrates in infectious and non-infectious uveitic study eyes were evaluated. Wide-field FAF and color fundus imaging results were compared regarding their diagnostic properties.
  
  
  RESULTS
  Nine out of 78 study eyes were diagnosed with infectious, 69 cases with non-infectious uveitis. Six infectious uveitic study eyes had changes of the peripheral fundus compared with 48 of 69 non-infectious uveitic eyes. In 33 (infectious versus non-infectious: 4 versus 29) cases, wide-field FAF images revealed more retinal or chorioretinal alterations or pathologies with a farther extended demarcation than wide-field composite color fundus imaging. Eleven out of 69 non-infectious study eyes were diagnosed with vasculitis which could be more precisely evaluated with wide-field FAF than wide-field composite color, green or red light filtered fundus imaging.
  
  
  CONCLUSIONS
  Non-invasive wide-field FAF detects more retinal or chorioretinal involvement in patients with posterior uveitis than seen in color imaging and thus is useful in diagnosis and follow-up of uveitic patients.
authors.affiliation: Department of Ophthalmology, Ludwig-Maximilians-University , Munich , Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Reznicek
authors.forename: Florian
authors.initials: F
authors.lastname: Seidensticker
authors.forename: Carmen
authors.initials: C
authors.lastname: Stumpf
authors.forename: Anselm
authors.initials: A
authors.lastname: Kampik
authors.forename: Stephan
authors.initials: S
authors.lastname: Thurau
authors.forename: Marcus
authors.initials: M
authors.lastname: Kernt
authors.forename: Aljoscha
authors.initials: A
authors.lastname: Neubauer
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002825:Chorioretinitis / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D031300:Retinal Vasculitis / Q000175:diagnosis*; D015866:Uveitis, Posterior / Q000175:diagnosis* / Q000382:microbiology; D014792:Visual Acuity / Q000502:physiology