title: The post-resuscitative urinalysis associate the survival of patients with non-traumatic out-of-hospital cardiac arrest.
abstract: OBJECTIVE
  To analyze whether urine output and urinalysis results are predictive of survival and neurologic outcomes in patients with non-traumatic out-of-hospital cardiac arrest (OHCA).
  
  
  METHODS
  Information was obtained from 1,340 patients with non-traumatic OHCA who had achieved a sustained return of spontaneous circulation (ROSC). Factors that were associated with survival in the post-resuscitative period were evaluated. The association between urine output and fluid challenge in the early resuscitative period was analyzed and compared between the survivors and the non-survivors. The results of the initial urinalysis, including the presence of proteinuria and other findings, were used to evaluate the severity of vascular protein leakage and survival. The association between proteinuria and the neurologic outcomes of the survivors was also analyzed. The clinical features of capillary leakage were examined during the post-resuscitative period.
  
  
  RESULTS
  Of the 1,340 patients, 312 survived. A greater urine output was associated with a higher chance of survival. The initial urine output increased in proportion to the amount of fluid that was administered during early resuscitation in the emergency department for the survivors but not for the non-survivors (p<0.05). In the initial urinalysis, proteinuria was strongly associated with survival, and severe proteinuria indicated significantly poorer neurologic outcomes (p<0.05 for both comparisons). Proteinuria was associated with a risk of developing signs of capillary leakage, including body mass index gain and pitting edema (both p<0.001).
  
  
  CONCLUSIONS
  The severity of proteinuria during the early post-resuscitative period was predictive of survival.
authors.affiliation: Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chin-Fu
authors.initials: CF
authors.lastname: Chang
authors.forename: Chao-Jui
authors.initials: CJ
authors.lastname: Li
authors.forename: Chih-Jan
authors.initials: CJ
authors.lastname: Ko
authors.forename: Tsung-Han
authors.initials: TH
authors.lastname: Teng
authors.forename: Shih-Chang
authors.initials: SC
authors.lastname: Lai
authors.forename: Mei-Chueh
authors.initials: MC
authors.lastname: Yang
authors.forename: Chun-Wen
authors.initials: CW
authors.lastname: Chiu
authors.forename: Chu-Chung
authors.initials: CC
authors.lastname: Chou
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Chang
authors.forename: Yung-Chiao
authors.initials: YC
authors.lastname: Yao
authors.forename: Lan-Hsin
authors.initials: LH
authors.lastname: Wu
authors.forename: Han-Ping
authors.initials: HP
authors.lastname: Wu
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Chen
authors.forename: Yan-Ren
authors.initials: YR
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000401:mortality*; D011507:Proteinuria / Q000150:complications; D016482:Urinalysis / Q000379:methods*