title: ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.
abstract: OBJECTIVE
  To evaluate the association between the genetic polymorphisms and haplotypes of the ITGA1 gene and the risk of gastric cancer.
  
  
  METHODS
  The study subjects were 477 age- and sex-matched case-control pairs. Genotyping was performed for 15 single nucleotide polymorphisms (SNPs) in ITGA1. The associations between gastric cancer and these SNPs and haplotypes were analyzed with multivariate conditional logistic regression models. Multiple testing corrections were carried out following methodology for controlling the false discovery rate. Gene-based association tests were performed using the versatile gene-based association study (VEGAS) method.
  
  
  RESULTS
  In the codominant model, the ORs for SNPs rs2432143 (1.517; 95%CI: 1.144-2.011) and rs2447867 (1.258; 95%CI: 1.051-1.505) were statistically significant. In the dominant model, polymorphisms of rs1862610 and rs2447867 were found to be significant risk factors, with ORs of 1.337 (95%CI: 1.029-1.737) and 1.412 (95%CI: 1.061-1.881), respectively. In the recessive model, only the rs2432143 polymorphism was significant (OR = 1.559, 95%CI: 1.150-2.114). The C-C type of ITGA1 haplotype block 2 was a significant protective factor against gastric cancer in the both codominant model (OR = 0.602, 95%CI: 0.212-0.709, P = 0.021) and the dominant model (OR = 0.653, 95%CI: 0.483-0.884). The ITGA1 gene showed a significant gene-based association with gastric cancer in the VEGAS test. In the dominant model, the A-T type of ITGA1 haplotype block 2 was a significant risk factor (OR = 1.341, 95%CI: 1.034-1.741). SNP rs2447867 might be related to the severity of gastric epithelial injury due to inflammation and, thus, to the risk of developing gastric cancer.
  
  
  CONCLUSIONS
  ITGA1 gene SNPs rs1862610, rs24321 43, and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer.
authors.affiliation: Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Yong-Dae Kim, Heon Kim, Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea.
authors.forename: Dong-Hyuk
authors.initials: DH
authors.lastname: Yim
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Zhang
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Eom
authors.forename: Sun In
authors.initials: SI
authors.lastname: Moon
authors.forename: Hyo-Yung
authors.initials: HY
authors.lastname: Yun
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Song
authors.forename: Sei-Jin
authors.initials: SJ
authors.lastname: Youn
authors.forename: Taisun
authors.initials: T
authors.lastname: Hyun
authors.forename: Joo-Seung
authors.initials: JS
authors.lastname: Park
authors.forename: Byung Sik
authors.initials: BS
authors.lastname: Kim
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Heon
authors.initials: H
authors.lastname: Kim
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D039423:Integrin alpha1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*
chemical_list: D039423:Integrin alpha1
keywords: Gastric cancer; Haplotype; ITGA1; Integrin; Polymorphism