title: Interleukin-17A expression in patients presenting with nasal polyposis.
abstract: Sinonasal polyposis (SNP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. Interleukin-17A (IL-17A) is a key inflammatory cytokine in many disorders. Little attention has been paid to the role of IL-17A in chronic inflammatory disorders.
  
  
  OBJECTIVE
  To investigate the expression of IL-17A in the SNP and verify if this expression is a marker of good or bad prognosis.
  
  
  METHODS
  Prospective study with 25 patients presenting with SNP were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups, and asthmatic or non-asthmatic.
  
  
  RESULTS
  The IL-17A expression was observed in both atopic and nonatopic patients. The numbers of IL-17A positive cells were greater in nasal polyps of atopic patients than nonatopic (p = 0.0128).
  
  
  CONCLUSIONS
  These results indicate that IL-17A may play an important role in the pathology of SNP. Considering the inflammatory properties of IL-17A, this study suggests that it could increase susceptibility to atopy and asthma.
authors.affiliation: Universidade Federal de Goiás.
authors.forename: Melissa Ameloti Gomes
authors.initials: MA
authors.lastname: Avelino
authors.forename: Isabela Jubé
authors.initials: IJ
authors.lastname: Wastowski
authors.forename: Ricardo Gimenes
authors.initials: RG
authors.lastname: Ferri
authors.forename: Thaís Gomes Abrahão
authors.initials: TG
authors.lastname: Elias
authors.forename: Ana Paula Lindoso
authors.initials: AP
authors.lastname: Lima
authors.forename: Larissa Mesquita
authors.initials: LM
authors.lastname: Nunes
authors.forename: Shirley Shizue Nagata
authors.initials: SS
authors.lastname: Pignatari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000150:complications / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D020381:Interleukin-17