title: Nicholas reactions in the synthesis of dicobalt dibenzocyclooctyne complexes.
abstract: Hexacarbonyldicobalt complexes of biaryl-substituted 4-methoxybutynones and 4-methoxy-2-butynes undergo intramolecular Nicholas reactions to form dibenzocyclooctyne-Co2(CO)6 complexes in good yields. Reductive decomplexation of the cyclization products is possible, and the method has been applied to a formal synthesis of isoschizandrin.
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor , Windsor, ON, Canada N9B 3P4.
authors.forename: Sinisa
authors.initials: S
authors.lastname: Djurdjevic
authors.forename: James R
authors.initials: JR
authors.lastname: Green