title: Positron emission tomography imaging of 5-hydroxytryptamine1B receptors in Parkinson's disease.
abstract: Impairment of the central serotonin system in Parkinson's disease (PD) has been shown postmortem and in vivo with positron emission tomography (PET). The aim of this PET study was to examine and compare the availability of the 5-hydroxytryptamine (5-HT)(1B)-receptor subtype in patients with PD and age-matched control subjects. Twelve control subjects and 12 PD patients were examined with PET using the 5-HT(1B)-radioligand [(11)C]AZ10419369. In PD patients, 5-HT(1B)-receptor availability in the right orbitofrontal cortex was lower than in control subjects. A statistically significant negative correlation between 5-HT(1B)-receptor availability and age was obtained for the right temporal cortex in control subjects and for the right midbrain and left parahippocampal gyrus in PD patients. The lower regional 5-HT(1B)-receptor availability is in line with previous studies showing a decrease of serotonin imaging markers in PD and corroborates a role of the serotonin system in the pathophysiology of PD. The demonstrated age effect on 5-HT(1B) receptors suggest a physiologic and PD-related decline of serotonin function, indicating the importance of controlling for age in clinical studies.
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden. Electronic address: andrea.varrone@ki.se.
authors.forename: Andrea
authors.initials: A
authors.lastname: Varrone
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Svenningsson
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
authors.forename: Anton
authors.initials: A
authors.lastname: Forsberg
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
authors.forename: Katarina
authors.initials: K
authors.lastname: Varnäs
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Tiger
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakao
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Halldin
authors.affiliation: Stockholm Brain Institute, Stockholm, Sweden; Department of Psychology, Stockholm University, Stockholm, Sweden.
authors.forename: Lars-Göran
authors.initials: LG
authors.lastname: Nilsson
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden; Stockholm Brain Institute, Stockholm, Sweden; AstraZeneca Translational Science Centre at Karolinska Institutet, Stockholm, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Farde
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D008032:Limbic System / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods*; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology
chemical_list: D015415:Biomarkers; D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin
keywords: 5-HT(1B); Aging; High-resolution PET; Limbic system; Parkinson's disease; Serotonin