title: Influence of vitamin D mushroom powder supplementation on exercise-induced muscle damage in vitamin D insufficient high school athletes.
abstract: Incidence of vitamin D deficiency is increasing worldwide. The purpose of this study was to determine if supplementation with vitamin D2 from Portobello mushroom powder would enhance skeletal muscle function and attenuate exercise-induced muscle damage in low vitamin D status high school athletes. Participants were randomised to Portobello mushroom powder (600 IU/d vitamin D2) or placebo for 6 weeks. Participants then completed a 1.5-h exercise session designed to induce skeletal muscle damage. Blood samples and measures of skeletal muscle function were taken pre-supplementation, post-supplementation/pre-exercise and post-exercise. Six weeks supplementation with vitamin D2 increased serum 25(OH)D2 by 9.9-fold and decreased serum 25(OH)D3 by 28%. Changes in skeletal muscle function and circulating markers of skeletal muscle damage did not differ between groups. In conclusion, 600 IU/d vitamin D2 increased 25(OH)D2 with a concomitant decrease in 25(OD)D3, with no effect on muscular function or exercise-induced muscle damage in high school athletes.
authors.affiliation: a Human Performance Laboratory , Appalachian State University , Kannapolis , NC , USA.
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Shanely
authors.forename: David C
authors.initials: DC
authors.lastname: Nieman
authors.forename: Amy M
authors.initials: AM
authors.lastname: Knab
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Gillitt
authors.forename: Mary Pat
authors.initials: MP
authors.lastname: Meaney
authors.forename: Fuxia
authors.initials: F
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Sha
authors.forename: Lynn
authors.initials: L
authors.lastname: Cialdella-Kam
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000293:Adolescent; D000364:Agaricus / Q000737:chemistry*; D056352:Athletes; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D002112:Calcifediol / Q000097:blood; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009135:Muscular Diseases / Q000097:blood* / Q000517:prevention & control; D012574:Schools; D013177:Sports; D014807:Vitamin D / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood*; D014815:Vitamins / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001688:Biological Products; D014815:Vitamins; D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2; D002112:Calcifediol