title: Copper-catalyzed trifluoromethylation-cyclization of enynes: highly regioselective construction of trifluoromethylated carbocycles and heterocycles.
abstract: Regioselective trifluoromethylation-cyclization: A method for copper-catalyzed trifluoromethylation-cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time. The reaction proceeds efficiently in a highly regioselective manner to give various 5- or 6-exo-dig carbocycles and heterocycles in moderate to high yields.
authors.affiliation: State key Laboratory of Applied Organic Chemistry lanzhou University, Lanzhou 730000 (P. R. China), Fax: (+86) 931-891-2582.
authors.forename: Pin
authors.initials: P
authors.lastname: Gao
authors.forename: Xiao-Biao
authors.initials: XB
authors.lastname: Yan
authors.forename: Tao
authors.initials: T
authors.lastname: Tao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Ting
authors.initials: T
authors.lastname: He
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D005461:Fluorine / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D005461:Fluorine; D002244:Carbon; D003300:Copper
keywords: copper; cyclization; enynes; regioselectivity; trifluoromethylation