title: Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: a meta-analysis.
abstract: OBJECTIVE
  The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship.
  
  
  METHODS
  We searched the PubMed, Embase, and Web of Science data- bases for studies related to the association between the ApoE genotype and the risk of RPL. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association.
  
  
  RESULTS
  Seven studies, including 2,090 RPL cases and 742 control samples, were identified. The results showed a significant association between ApoE E4 mutation and RPL risk (for E4 allele: OR =1.98, 95 %CI =1.14-3.43, P=0.499; for E2E3 vs. E3E3: OR =1.33, 95%CI =1.12-1.42, P=0.008; for E2E4 vs. E3E3: OR =1.26, 95 % CI =1.07-1.49, P=0.005).
  
  
  CONCLUSIONS
  The meta-analysis suggests an association between ApoE E4 mutation and increased risk of RPL.
authors.affiliation: Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot, 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Meng
authors.forename: Mu-ge
authors.initials: MG
authors.lastname: Qi
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Yi
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Liu
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics* / Q000473:pathology; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E