title: Developmental disorders of the dentition: an update.
abstract: Dental anomalies are common congenital malformations that can occur either as isolated findings or as part of a syndrome. This review focuses on genetic causes of abnormal tooth development and the implications of these abnormalities for clinical care. As an introduction, we describe general insights into the genetics of tooth development obtained from mouse and zebrafish models. This is followed by a discussion of isolated as well as syndromic tooth agenesis, including Van der Woude syndrome (VWS), ectodermal dysplasias (EDs), oral-facial-digital (OFD) syndrome type I, Rieger syndrome, holoprosencephaly, and tooth anomalies associated with cleft lip and palate. Next, we review delayed formation and eruption of teeth, as well as abnormalities in tooth size, shape, and form. Finally, isolated and syndromic causes of supernumerary teeth are considered, including cleidocranial dysplasia and Gardner syndrome.
authors.forename: Ophir D
authors.initials: OD
authors.lastname: Klein
authors.forename: Snehlata
authors.initials: S
authors.lastname: Oberoi
authors.forename: Ann
authors.initials: A
authors.lastname: Huysseune
authors.forename: Maria
authors.initials: M
authors.lastname: Hovorakova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Peterka
authors.forename: Renata
authors.initials: R
authors.lastname: Peterkova
mesh_terms: D000015:Abnormalities, Multiple / Q000503:physiopathology; D000818:Animals; D000869:Anterior Eye Segment / Q000002:abnormalities / Q000503:physiopathology; D002971:Cleft Lip / Q000150:complications / Q000503:physiopathology; D002972:Cleft Palate / Q000150:complications / Q000503:physiopathology; D003560:Cysts / Q000150:complications / Q000503:physiopathology; D003817:Dentition; D002658:Developmental Disabilities / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D004476:Ectodermal Dysplasia / Q000150:complications / Q000503:physiopathology; D005124:Eye Abnormalities / Q000150:complications / Q000503:physiopathology; D015785:Eye Diseases, Hereditary; D016142:Holoprosencephaly / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008046:Lip / Q000002:abnormalities / Q000503:physiopathology; D051379:Mice; D009958:Orofaciodigital Syndromes / Q000150:complications / Q000503:physiopathology; D014070:Tooth / Q000254:growth & development* / Q000473:pathology*
keywords: craniofacial; hypodontia; mouse; supernumerary teeth; syndrome; teeth; zebrafish