title: Lauroyl-L-aspartate decreased food intake and body temperature in neonatal chicks.
abstract: We hypothesized that the effects of L- and D-amino acids might be influenced when conjugated with fatty acid. Thus, the effects of oral administration of lauroyl-L-aspartate (Lau-L-Asp) as well as lauroyl-D-aspartate (Lau-D-Asp) were examined. In Experiment 1, oral administration of both Lau-L-Asp and Lau-D-Asp decreased food intake while L- or D-Asp did not influence food intake. Interestingly, only Lau-L-Asp decreased body temperature. Experiment 2 was conducted to determine whether non-conjugated mixture of L-Asp plus lauric acid has same effects under ad libitum feeding conditions. Lau-L-Asp decreased food intake and body temperature, but L-Asp plus lauric acid did not show any effect studied. In Experiment 3, we found that Lau-L-Asp declined food intake as well as time-dependently suppressed the body temperature in fasted chicks. However, L-Asp plus lauric acid did not show any effect. These results suggest that Lau-L-Asp may exert anorexigenic and hypothermic actions in chicks.
authors.affiliation: Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Erwan
authors.forename: V S
authors.initials: VS
authors.lastname: Chowdhury
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001224:Aspartic Acid / Q000737:chemistry / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D002645:Chickens; D004435:Eating / Q000187:drug effects*; D007850:Lauric Acids / Q000737:chemistry*
chemical_list: D007850:Lauric Acids; C030358:lauric acid; D001224:Aspartic Acid
keywords: Body temperature; Food intake; Lauroyl-l- or -d-aspartate