title: Differential gene expression of the key signalling pathway in para-carcinoma, carcinoma and relapse human pancreatic cancer.
abstract: Pancreatic cancer (PC) has a high rate of mortality and a poorly understood mechanism of progression. Investigation of the molecular mechanism of PC and exploration of the specific markers for early diagnosis and specific targets of therapy are key points to prevent and treat PC effectively and to improve their prognosis. In our study, expression profiles experiment of para-carcinoma, carcinoma and relapse human PC was performed using Agilent human whole genomic oligonucleotide microarrays with 45 000 probes. Differentially expressed genes related with PC were screened and analysed further by Gene Ontology term analysis and Kyoto encyclopaedia of genes and genomes pathway analysis. Our results showed that there were 3853 differentially expressed genes associated with pancreatic carcinogenesis and relapse. In addition, our study found that PC was related to the Jak-STAT signalling pathway, PPAR signalling pathway and Calcium signalling pathway, indicating their potential roles in pancreatic carcinogenesis and progress.
authors.affiliation: Veterinary Faculty, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
authors.forename: Zheng-Yan
authors.initials: ZY
authors.lastname: Chang
authors.forename: Ran
authors.initials: R
authors.lastname: Sun
authors.forename: Yu-Shui
authors.initials: YS
authors.lastname: Ma
authors.forename: Da
authors.initials: D
authors.lastname: Fu
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Lai
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Li
authors.forename: Xing-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhang
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Lv
authors.forename: Xian-Ling
authors.initials: XL
authors.lastname: Cong
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Li
mesh_terms: D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D063990:Gene Ontology; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D020411:Oligonucleotide Array Sequence Analysis; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
keywords: Jak-STAT signalling pathway; PPAR signalling pathway; calcium signalling pathway; carcinogenesis; microarray; pancreatic cancer; relapse