title: An efficient and facile methodology for bromination of pyrimidine and purine nucleosides with sodium monobromoisocyanurate (SMBI).
abstract: An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure.
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institute (KI), Novum, Huddinge SE-141 83, Sweden. Jyotirmoy.Maity@ki.se.
authors.forename: Jyotirmoy
authors.initials: J
authors.lastname: Maity
authors.forename: Roger
authors.initials: R
authors.lastname: Stromberg
mesh_terms: D004126:Dimethylformamide / Q000737:chemistry; D054879:Halogenation; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D014227:Triazines / Q000737:chemistry*
chemical_list: D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D012997:Solvents; D014227:Triazines; C516817:bromoisocyanuric acid; D004126:Dimethylformamide