title: Atrial fibrillation in heart failure: catheter and surgical interventional therapies.
abstract: Atrial fibrillation and heart failure commonly coexist in the same patient. Each may adversely affect the other. Atrial fibrillation leads to heart failure exacerbation, left ventricular function deterioration and an increase in thrombo-embolic risk. Therapeutic options targeting atrial fibrillation in heart failure patients include pharmacological and non-pharmacological means. Pharmacological therapy is directed at either rate control using nodal blocking agents or rhythm control using anti-arrhythmic agents, of which the options are limited in patients with heart failure. The landmark AF-CHF trial did not show any benefit of rhythm control strategy as opposed to rate control in patients with heart failure and atrial fibrillation. However, patients in this trial as well as in others used mostly amiodarone for rhythm control. This might have negated any positive effects of achieving normal sinus rhythm. Non-pharmacological therapy both for rate and rhythm control is appealing. This includes AV node ablation for rate control, catheter ablation of atrial fibrillation and surgical therapy of atrial fibrillation. This review will address non-pharmacologic treatment of AF in heart failure patients.
authors.affiliation: Cleveland Clinic, 9500 Euclid Ave., Desk J2-2, Cleveland, OH, 44195, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Rabah
authors.forename: Oussama
authors.initials: O
authors.lastname: Wazni
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D057186:Comparative Effectiveness Research; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D017063:Outcome Assessment, Health Care; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000889:Anti-Arrhythmia Agents