title: Changes in oxidant and antioxidant status of females with experimental gestosis under the effect of GABA derivatives.
abstract: Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition of SOD and glutathione peroxidase in the brain, liver, and uterus of animals with gestosis. Citrocard and saliphene (GABA derivatives) inhibited LPO (reduced MDA concentrations in the studied organs) and activated antioxidant enzymes in experimental gestosis.
authors.affiliation: Department of Pharmacology and Biopharmacy, Faculty for Advanced Medical Training, Institute of Pharmacology, Volgograd State Medical University, Russia. vnperfilova@mail.ru.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: T A
authors.initials: TA
authors.lastname: Popova
authors.forename: L B
authors.initials: LB
authors.lastname: Ivanova
authors.forename: I I
authors.initials: II
authors.lastname: Prokofiev
authors.forename: O V
authors.initials: OV
authors.lastname: Gulyaeva
authors.forename: L I
authors.initials: LI
authors.lastname: Stepa
mesh_terms: D000818:Animals; D005260:Female; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000188:drug therapy*; D011247:Pregnancy; D051381:Rats; D012965:Sodium Chloride / Q000009:adverse effects; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride; D005680:gamma-Aminobutyric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C008842:4-amino-3-phenylbutyric acid