title: Double-positive CD4/CD8 mycosis fungoides: a rarely reported immunohistochemical profile.
abstract: Mycosis fungoides (MF) represents the most common epidermotropic cutaneous T-cell lymphoma (CTCL), and tumor cells typically express a mature T-helper memory phenotype. A minority of MF patients display an unusual phenotype, which may be either CD4(-)/CD8(+) or double negative. Herein, we report a case of biopsy-proven MF in a 31-year-old woman who presented with infiltrated plaques involving photoprotected areas of the skin. Immunohistochemical study combined with confocal microscopy revealed co-expression of CD4 and CD8 in a subset of atypical T lymphocytes. To our knowledge, this is the second report of a CD4/CD8 dual-positive MF.
authors.affiliation: Laboratoire d'Anatomie Pathologique, CHU Purpan, Toulouse, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Tournier
authors.forename: Camille
authors.initials: C
authors.lastname: Laurent
authors.forename: Marianne
authors.initials: M
authors.lastname: Thomas
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.forename: Roland
authors.initials: R
authors.lastname: Viraben
authors.forename: Pierre
authors.initials: P
authors.lastname: Brousset
authors.forename: Laurence
authors.initials: L
authors.lastname: Lamant
mesh_terms: D000328:Adult; D015704:CD4 Antigens / Q000276:immunology / Q000378:metabolism*; D016827:CD8 Antigens / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D009182:Mycosis Fungoides / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens
keywords: T-cell phenotype; confocal microscopy; immunohistochemistry; mycosis fungoides