title: Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium.
abstract: The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verification using targeted mass spectrometry methods.
authors.affiliation: 1Division of Oncology and 2Division of Endocrinology and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; 3The Broad Institute of MIT and Harvard, Cambridge, Massachusetts; 4Fred Hutchinson Cancer Research Center, Seattle; 5Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington; 6Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, Maryland; and 7The Jim Ayers Institute for Cancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellis
authors.forename: Michael
authors.initials: M
authors.lastname: Gillette
authors.forename: Steven A
authors.initials: SA
authors.lastname: Carr
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Paulovich
authors.forename: Richard D
authors.initials: RD
authors.lastname: Smith
authors.forename: Karin K
authors.initials: KK
authors.lastname: Rodland
authors.forename: R Reid
authors.initials: RR
authors.lastname: Townsend
authors.forename: Christopher
authors.initials: C
authors.lastname: Kinsinger
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mesri
authors.forename: Henry
authors.initials: H
authors.lastname: Rodriguez
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology; D005260:Female; D015894:Genome, Human; D023281:Genomics; D005838:Genotype; D006801:Humans; D058977:Molecular Sequence Annotation; D009154:Mutation; D054547:National Cancer Institute (U.S.); D054560:National Human Genome Research Institute (U.S.); D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D040901:Proteomics; D014481:United States
chemical_list: D014408:Biomarkers, Tumor