title: Identification of silver nanoparticles in the small intestinal mucosa, liver, and spleen of rats by transmission electron microscopy.
abstract: The effects of water-dispersed Ag nanoparticles on the small intestinal mucosa, liver, and spleen of rats were studied by transmission electron microscopy. Acute experiments demonstrated penetration of Ag nanoparticles injected into the isolated intestinal loop into the intestinal mucosa, liver, and splenic tissues. Ultrastructural changes (lobed nucleus, megamitochondria) were found in the studied organs. These data indicated that injection of water-dispersed Ag nanoparticles into the gastrointestinal tract was followed by their penetration through the epithelium of the small intestinal mucosa into other organs, e.g. into the liver and spleen. This fact is essential for evaluation of potential risks of the nanoparticle effects on human health and environment.
authors.affiliation: A. N. Bach Institute of Biochemistry, the Russian Academy of Sciences; Institute of Nutrition, the Russian Academy of Medical Sciences, Moscow, Russia. sh-p_s@mail.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Platonova
authors.forename: S M
authors.initials: SM
authors.lastname: Pridvorova
authors.forename: A V
authors.initials: AV
authors.lastname: Zherdev
authors.forename: L S
authors.initials: LS
authors.lastname: Vasilevskaya
authors.forename: E A
authors.initials: EA
authors.lastname: Arianova
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinski
authors.forename: S A
authors.initials: SA
authors.lastname: Khotimchenko
authors.forename: B B
authors.initials: BB
authors.lastname: Dzantiev
authors.forename: V O
authors.initials: VO
authors.lastname: Popov
authors.forename: V A
authors.initials: VA
authors.lastname: Tutelyan
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000166:cytology; D007413:Intestinal Mucosa / Q000166:cytology*; D007421:Intestine, Small / Q000166:cytology; D008099:Liver / Q000166:cytology*; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008928:Mitochondria; D010581:Peyer's Patches / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000737:chemistry; D013154:Spleen / Q000166:cytology*; D014018:Tissue Distribution
chemical_list: D012834:Silver