title: Prevention and treatment of intraluminal catheter thrombosis in children hospitalised in a paediatric intensive care unit.
abstract: OBJECTIVE
  The aim of the study was to develop and implement a protocol for the prevention and treatment of catheter related intraluminal thrombosis in a paediatric intensive care unit
  
  
  METHODS
  A computerised search was carried out on MEDLINE, through PubMed, using the medical subject heading 'central venous catheter', 'central venous access device', 'central venous line' associated with 'occlusion', 'obstruction', 'catheter-related thrombosis', 'critically ill patients' and 'thrombolytic therapy'. References of reviewed articles were also searched for relevant titles as well as non-randomised controlled trials and series of cases when no information of higher level of evidence was available.
  
  
  RESULTS
  With the information gathered, a protocol for the prevention and treatment of catheter related intraluminal thrombosis was elaborated and those recommendations that best suit our environment were included. They were agreed upon by a broad panel of professionals working in the Pediatric Intensive Care Unit and the Pharmacy Department.
  
  
  CONCLUSIONS
  Due to the variety of options available for the pharmacotherapeutic management of intraluminal catheter thrombosis, one measure to improve the quality of the therapy and to diminish the variability in the prescription could be the implementation of a protocol as described in this paper.
authors.affiliation: Pharmacy Department, Gregorio Marañón University General Hospital, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: de Lorenzo-Pinto
authors.forename: Amelia C
authors.initials: AC
authors.lastname: Sánchez-Galindo
authors.forename: Silvia
authors.initials: S
authors.lastname: Manrique-Rodríguez
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Fernández-Llamazares
authors.forename: Sarah Nicole
authors.initials: SN
authors.lastname: Fernández-Lafever
authors.forename: Miriam García
authors.initials: MG
authors.lastname: San-Prudencio
authors.forename: Lucía
authors.initials: L
authors.lastname: Cortejoso
authors.forename: María
authors.initials: M
authors.lastname: Sanjurjo-Sáez
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002648:Child; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D015278:Intensive Care Units, Pediatric; D020246:Venous Thrombosis / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D005343:Fibrinolytic Agents
keywords: catheters; heparin; intensive care units; thrombolytic therapy