title: Structures of class B G protein-coupled receptors: prospects for drug discovery.
abstract: New members in the GPCR photo gallery! Crystal structures of class B G protein-coupled receptors, which bind peptide hormones, have been solved [see picture of the corticotropin-releasing factor receptor 1 (blue) and a bound allosteric nonpeptide antagonist (green)]. The structures provide a basis for a rational design of better drugs for diabetes, osteoporosis, migraine, or depression.
authors.affiliation: AG Chemical Genomics, Max Planck Institute of Psychiatry, Kraepelinstr. 2, München (Germany) http://www.mpipsykl.mpg.de/en/research/groups/hausch/index.html. hausch@mpipsykl.mpg.de.
authors.forename: Felix
authors.initials: F
authors.lastname: Hausch
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D005934:Glucagon / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled; D005934:Glucagon
keywords: GPCRs; drug design; glucagon; receptors; structure elucidation