title: Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley.
abstract: The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 μg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 μg/mL) against B. cereus.
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Sivasothy
authors.forename: Halijah
authors.initials: H
authors.lastname: Ibrahim
authors.forename: Audra Shaleena
authors.initials: AS
authors.lastname: Paliany
authors.forename: Siti Aisyah
authors.initials: SA
authors.lastname: Alias
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes
keywords: Alpinia pahangensis Ridley; Antibacterial agent; Bis-labdanic diterpene; Labdane diterpene; Pahangensin A; Pahangensin B; Zingiberaceae