title: A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions.
abstract: Pregabalin is approved for the treatment of a variety of clinical conditions and its analgesic, anxiolytic and anticonvulsant properties are well documented. Pregabalin's effects on sleep, however, are less well known. This review summarizes the published data on the effects of pregabalin on sleep disturbance associated with neuropathic pain, fibromyalgia, restless legs syndrome, partial onset seizures and general anxiety disorder. The data demonstrate that pregabalin has a positive benefit on sleep disturbance associated with several different clinical conditions. Polysomnographic data reveal that pregabalin primarily affects sleep maintenance. The evidence indicates that pregabalin has a direct effect on sleep that is distinct from its analgesic, anxiolytic and anticonvulsant effects.
authors.affiliation: Division of Sleep Medicine and Research Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address: troth1@hfhs.org.
authors.forename: Thomas
authors.initials: T
authors.lastname: Roth
authors.affiliation: Women's Health Research Program, University of Cincinnati, 260 Stetson Street, Suite 3200, Cincinnati, OH 45219, USA. Electronic address: Lesley.Arnold@uc.edu.
authors.forename: Lesley M
authors.initials: LM
authors.lastname: Arnold
authors.affiliation: Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain. Electronic address: dgb@iis.es.
authors.forename: Diego
authors.initials: D
authors.lastname: Garcia-Borreguero
authors.affiliation: Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA. Electronic address: malca.resnick@pfizer.com.
authors.forename: Malca
authors.initials: M
authors.lastname: Resnick
authors.affiliation: Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA. Electronic address: andrew.clair@pfizer.com.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Clair
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy; D004828:Epilepsies, Partial / Q000188:drug therapy; D005356:Fibromyalgia / Q000188:drug therapy; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy; D017286:Polysomnography / Q000187:drug effects; D000069583:Pregabalin; D012148:Restless Legs Syndrome / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid
keywords: Patient-report; Polysomnography; Pregabalin; Sleep disturbance