title: Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis. A double-blind randomised, placebo-controlled, prospective trial.
abstract: OBJECTIVE
  To compare the efficacy of meloxicam and a glucosamine-chondroitin (Glu-Ch) supplement in the management of feline osteoarthritis (OA).
  
  
  METHODS
  Prospective, blinded, randomized clinical trial. Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days, followed by a placebo until day 98. Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time.
  
  
  RESULTS
  Data were collected from thirty cats. Pre-treatment disease scores were significantly higher in the meloxicam group for owner mobility (p=0.01) and veterinary lameness (p=0.02). Owner mobility scores at day 14 (p=0.01) and day 42 (p=0.002) were significantly improved compared to pre-treatment scores for the meloxicam group. When meloxicam and Glu-Ch were discontinued and the placebo commenced, a significant proportion of the meloxicam group showed worsening of all the owner-assessed scores between day 70 and day 98, when compared to the Glu-Ch group (mobility p=0.01; activity p=0.02; temperament p=0.04; lifestyle p=0.01).
  
  
  CONCLUSIONS
  Treatment with meloxicam resulted in a significant improvement in mobility and activity levels of cats with OA until the placebo was introduced. A greater proportion of cats receiving meloxicam medication showed a significant worsening of owner assessment scores once the placed was introduced, when compared to the Glu-Ch group.
authors.affiliation: Rui M. Sul, LMV MRCVS, Small Animal Hospital, School of Veterinary Medicine, University of Glasgow, 464 Bearsden Road, Glasgow G61 1QH, United Kingdom, Phone: +44 141 330 5848, Fax: +44 141 330 3663, Email: r.sul.1@research.gla.ac.uk.
authors.forename: R M
authors.initials: RM
authors.lastname: Sul
authors.forename: D
authors.initials: D
authors.lastname: Chase
authors.forename: T
authors.initials: T
authors.lastname: Parkin
authors.forename: D
authors.initials: D
authors.lastname: Bennett
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002807:Chondroitin / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D005944:Glucosamine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D000077239:Meloxicam; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D013843:Thiazines / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D002807:Chondroitin; D005944:Glucosamine; D000077239:Meloxicam
keywords: Feline; chondroitin; glucosamine; meloxicam; osteoarthritis