title: The Pleiotropic Effects of miRNAs on Tumor Angiogenesis.
abstract: Angiogenesis, the process of new blood vessel formation and growth from already existing venules is critical in vascular development and homeostasis controlled by the balance of pro- and anti-angiogenic factors. Emerging evidence indicates the development, progression, and metastasis of various human cancers are strongly relied on angiogenesis. However, molecular mechanisms that underlie the complex regulation of angiogenic processes are still not fully elucidated. Recent studies revealed that microRNAs (miRNAs) were important regulators of tumor angiogenesis and the entire research in this area has entered into a so-called "miRNAs era." Thus, miRNAs might be important therapeutic targets or biomarkers for cancer. Due to the complexity of miRNA regulating mechanisms, how specific miRNAs intersect with and modulate tumor angiogenesis is still unclear. The conflicting results of the same miRNAs from different groups indicated that miRNAs might possess potent activity in a cell type or cell context specific manner. Here, we present a summary of latest advances in understanding the roles of angiogenic miRNAs as potential tools or targets in cancer therapy.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, P.R. China.|Jiangsu Province Key Laboratory of Tumor Biological Therapy, Xuzhou Medical College, Xuzhou 221000, P.R. China.
authors.forename: Runting
authors.initials: R
authors.lastname: Yin
authors.affiliation: School of Laboratory Medicine, Ningxia Medical University, Yinchuan, 750004, P.R. China.
authors.forename: Le
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, School of Pharmacy, Nantong University, Nantong 226001, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Jiangsu Province Key Laboratory of Tumor Biological Therapy, Xuzhou Medical College, Xuzhou 221000, P.R. China.
authors.forename: Junnian
authors.initials: J
authors.lastname: Zheng
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: ANGIOGENESIS; CANCER; miRNAs