title: Synthesis, characterization, DNA interaction, antioxidant and anticancer activity of new ruthenium(II) complexes of thiosemicarbazone/semicarbazone bearing 9,10-phenanthrenequinone.
abstract: A new series of octahedral ruthenium(II) complexes supported by tridentate ligands derived from phenanthrenequinone and derivatives of thiosemicarbazide/semicarbazide and other co-ligands have been synthesized and characterized. DNA binding experiments indicated that ruthenium(II) complexes can interact with DNA through non-intercalation and the apparent binding constant value (Kb) of [RuCl(CO)(PPh₃)(L₃)] (3) at room temperature was calculated to be 2.27 × 10(3)M(-1). The DNA cleavage studies showed that the complexes have better cleavage of pBR 322 DNA. Antioxidative activity proved that the complexes have significant radical scavenging activity against free radicals. Cytotoxic activities showed that the ruthenium(II) complexes exhibited more effective cytotoxic activity against selected cancer cells.
authors.affiliation: Department of Chemistry, Periyar University, Salem 636 011, Tamil Nadu, India.
authors.forename: Panneerselvam
authors.initials: P
authors.lastname: Anitha
authors.forename: Nataraj
authors.initials: N
authors.lastname: Chitrapriya
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Jang
authors.forename: Periasamy
authors.initials: P
authors.lastname: Viswanathamurthi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000633:toxicity; D061986:MCF-7 Cells; D010616:Phenanthrenes / Q000737:chemistry; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry*; D012664:Semicarbazones / Q000737:chemistry; D013696:Temperature; D014783:Viscosity
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D007364:Intercalating Agents; D010616:Phenanthrenes; D012664:Semicarbazones; C005399:9,10-phenanthrenequinone; D012428:Ruthenium; D004247:DNA
keywords: Anticancer activity; Antioxidant; DNA binding; DNA cleavage; Ruthenium(II) complexes