title: Class I myosins in B-cell physiology: functions in spreading, immune synapses, motility, and vesicular traffic.
abstract: Myosins comprise a family of motor proteins whose role in muscle contraction and motility in a large range of eukaryotic cells has been widely studied. Although these proteins have been characterized extensively and much is known about their function in different cellular compartments, little is known about these molecules in hematopoietic cells. Myosins expressed by cells from the immune response are involved in maintaining plasma membrane tension, moving and secreting vesicles, endo- and exocytotic processes, and promoting the adhesion and motility of cells. Herein, we summarize our current understanding of class I myosins in B cells, with an emphasis on the emerging roles of these molecular motors in immune functions.
authors.affiliation: Departamento de Biomedicina Molecular, CINVESTAV-IPN, México, DF, México.
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Santos-Argumedo
authors.forename: José Luis
authors.initials: JL
authors.lastname: Maravillas-Montero
authors.forename: Orestes
authors.initials: O
authors.lastname: López-Ortega
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology*; D002465:Cell Movement; D006801:Humans; D054992:Immunological Synapses / Q000502:physiology; D024461:Myosin Type I / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism
chemical_list: D024461:Myosin Type I
keywords: B lymphocyte; cytoskeleton; myosin I