title: An L-DNA G-quadruplex: application for peroxidase DNAzyme.
abstract: L-DNA is the mirror-image form of natural D-DNA. We demonstrate that one left-handed G-rich sequence can form an L-DNA intramolecular G-quadruplex. Further investigation revealed that a DNAzyme formed by an L-nucleotide G-quadruplex exhibited peroxidase catalytic efficiency. The enhancement of the color change of the oxygenation product ABTS(•-) caused by L-nucleotide G-quadruplex formation could be clearly observed with naked eyes. This research provides a new concept for the application of the L-DNA peroxidase DNAzyme complex in nuclease-containing biological systems.
authors.affiliation: a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education , Wuhan University , Wuhan , Hubei , P. R. China.
authors.forename: Libo
authors.initials: L
authors.lastname: Yuan
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhengan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000042:Absorption; D002942:Circular Dichroism; D021881:DNA, Catalytic / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D054856:G-Quadruplexes; D009195:Peroxidase / Q000378:metabolism*; D013997:Time Factors
chemical_list: D021881:DNA, Catalytic; D009195:Peroxidase