title: Cancer-associated osteoclast differentiation takes a good look in the miR(NA)ror.
abstract: Tumor-bone cell interactions are critical for the development of metastasis-related osteolytic bone destruction. In this issue of Cancer Cell, Ell and colleagues show how a discrete miRNA network regulates osteoclastogenesis during breast cancer bone metastasis. A signature of upregulated miRNAs may have diagnostic and therapeutic implications for bone metastases.
authors.affiliation: Division of Endocrinology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Waning
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Mohammad
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Guise
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001859:Bone Neoplasms / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs