title: Intense pulsed light versus benzoyl peroxide 5% gel in treatment of acne vulgaris.
abstract: Acne is a common disorder affecting the pilosebaceous unit. Despite many advances in the treatments of acne vulgaris the best option is still controversial as the pathogenesis of acne is rather complex, necessitating various combination therapies. The objective of this study is to compare the clinical efficacy of intense pulsed light therapy (IPL) versus benzoyl peroxide 5% for the treatment of inflammatory acne. Fifty patients of both sexes, (15 males and 35 females) aged (18-27 years), with mild-to-severe acne and Fitzpatrick skin phototype IV were enrolled in this study. The patients were equally divided into two groups. The first group was treated by benzoyl peroxide while the second group was treated by IPL. For both therapies, patients experienced a significant reduction in the mean of the inflammatory lesion counts over the treatment period. Comparing the effects of both therapies, BP produced better results than IPL. The difference in the results was statistically significant at the midpoint of the study. However, this difference was insignificant at the end of study. Treatment with both benzoyl peroxide and IPL resulted in considerable improvement of the acne after 5 weeks of treatment. Comparing the effects of both therapies, BP produced better results than IPL. The difference in the results was statistically significant at the midpoint of the study. However, this difference was insignificant at the end of study.
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
authors.forename: Azmy Ahmed Abd
authors.initials: AA
authors.lastname: El-Latif
authors.forename: Faisal Abdel Aziz
authors.initials: FA
authors.lastname: Hassan
authors.forename: Ahmed Rashad
authors.initials: AR
authors.lastname: Elshahed
authors.forename: Amr Ghareeb
authors.initials: AG
authors.lastname: Mohamed
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Elsaie
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000628:therapy*; D000328:Adult; D001585:Benzoyl Peroxide / Q000627:therapeutic use*; D005260:Female; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D062325:Intense Pulsed Light Therapy; D008297:Male; D055815:Young Adult
chemical_list: D005782:Gels; D001585:Benzoyl Peroxide