title: Sudden hearing loss associated with methylphenidate therapy.
abstract: An 8-year-old child diagnosed with attention deficit/hyperactivity disorder presented to our Department of Otolaryngology 4 days after suffering hearing loss, loss of balance, tinnitus, and fullness sensation of the left ear. Her symptoms occured with the first dose of methylphenidate. The medical history and physical examination revealed no other diseases associated with sudden hearing loss. The audiogram revealed a total hearing loss on the left ear. Stapedial reflexes, distortion product and transient-evoked otoacoustic emissions were absent in left ear. The absence of clinical, laboratory and radiological evidence of a possible cause for complaints, an association between methylphenidate and sudden hearing loss was suggested. The patient received a standard course of oral corticosteroid and hyperbaric oxygen therapy. Weekly otological and audiological examinations were performed. Conservative and medical treatments offered no relief from hearing loss. Sudden hearing loss is a serious and irreversible adverse effect of methylphenidate. Therefore, the risk of hearing loss should be taken into consideration when initiating methylphenidate therapy.
authors.affiliation: Department of Otorhinolaryngology, Agri Military Hospital, Agri, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Karapinar
authors.forename: Omer
authors.initials: O
authors.lastname: Saglam
authors.forename: Engin
authors.initials: E
authors.lastname: Dursun
authors.forename: Bilal
authors.initials: B
authors.lastname: Cetin
authors.forename: Nergis
authors.initials: N
authors.lastname: Salman
authors.forename: Murat
authors.initials: M
authors.lastname: Sahan
mesh_terms: D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006309:Hearing / Q000187:drug effects; D003639:Hearing Loss, Sudden / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects*; D011241:Prednisone / Q000008:administration & dosage
chemical_list: D000697:Central Nervous System Stimulants; D005938:Glucocorticoids; D008774:Methylphenidate; D011241:Prednisone