title: Iothalamate versus estimated GFR in a Hispanic-dominant pediatric renal transplant population.
abstract: BACKGROUND
  Accurate knowledge of glomerular filtration rate (GFR) is essential to the practice of nephrology. Routine surveillance of GFR is most commonly executed using estimated GFR (eGFR) calculations, most often from serum creatinine measurements. However, cystatin C-based equations have demonstrated earlier sensitivity to decline in renal function. The literature regarding eGFR from cystatin C has few references that include transplant recipients. Additionally, for most of the published eGFR equations, patients of Hispanic ethnicity have not been enrolled in sufficient numbers.
  
  
  METHODS
  The applicability of several eGFR equations to the pediatric kidney transplant population at our center were compared in the context of determining whether Hispanic ethnicity was associated with equation performance.
  
  
  RESULTS
  Updated Schwartz, CKiD, and Zappitelli eGFR estimation equations demonstrated the highest correlations.
  
  
  CONCLUSIONS
  The authors recommend further prospective investigations to validate and identify factors contributing to these findings.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Papez
authors.forename: Gina-Marie
authors.initials: GM
authors.lastname: Barletta
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hsieh
authors.forename: Mark
authors.initials: M
authors.lastname: Joseph
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Morgenstern
mesh_terms: D000293:Adolescent; D001130:Arizona / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002648:Child; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006630:Hispanic or Latino; D006801:Humans; D007483:Iothalamic Acid; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008954:Models, Biological; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology / Q000601:surgery; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D007483:Iothalamic Acid; D003404:Creatinine