title: Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea.
abstract: OBJECTIVE
  To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA).
  
  
  METHODS
  The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/ hour initially randomized, 812 had body weight measured at baseline and after 6 months of study.
  
  
  METHODS
  CPAP or Sham CPAP.
  
  
  METHODS
  Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score.
  
  
  RESULTS
  Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014).
  
  
  CONCLUSIONS
  OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.
  
  
  CONCLUSIONS
  A commentary on this article appears in this issue on page 995.
  
  
  BACKGROUND
  Quan SF; Budhiraja R; Clarke DP; Goodwin JL; Gottlieb DJ; Nichols DA; Simon RD; Smith TW; Walsh JK; Kushida CA. Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea.
authors.affiliation: Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA ; Arizona Respiratory Center, University of Arizona, Tucson, AZ.
authors.forename: Stuart F
authors.initials: SF
authors.lastname: Quan
authors.forename: Rohit
authors.initials: R
authors.lastname: Budhiraja
authors.forename: Denise P
authors.initials: DP
authors.lastname: Clarke
authors.forename: James L
authors.initials: JL
authors.lastname: Goodwin
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gottlieb
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Nichols
authors.forename: Richard D
authors.initials: RD
authors.lastname: Simon
authors.forename: Terry W
authors.initials: TW
authors.lastname: Smith
authors.forename: James K
authors.initials: JK
authors.lastname: Walsh
authors.forename: Clete A
authors.initials: CA
authors.lastname: Kushida
mesh_terms: D000328:Adult; D000886:Anthropometry; D001835:Body Weight; D045422:Continuous Positive Airway Pressure / Q000009:adverse effects* / Q000379:methods; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D017286:Polysomnography; D011788:Quality of Life; D018570:Risk Assessment; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain
keywords: Continuous positive airway pressure; obstructive sleep apnea; weight