title: [Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy].
abstract: A considerable tear endothelin-1 increase (2-3 times) has been found in patients with primary open-angle glaucoma and proliferative diabetic retinopathy. Patients with proliferative retinopathy also showed an increase of plasminogen level in tear fluid and a tendency of a similar increase in blood serum. No correlation between endothelin-1 and plasminogen levels in these pathologies was established. Tear endothelin-1 and plasminogen measurement could be used as an informative and non-invasive method to help prognosis making, condition severity evaluation and control the effectiveness of treatment of ocular local microcirculatory disturbances.
authors.forename: T A
authors.initials: TA
authors.lastname: Pavlenko
authors.forename: N B
authors.initials: NB
authors.lastname: Chesnokova
authors.forename: H G
authors.initials: HG
authors.lastname: Davydova
authors.forename: T D
authors.initials: TD
authors.lastname: Okhotsimskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Beznos
authors.forename: A V
authors.initials: AV
authors.lastname: Grigor'ev
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism* / Q000503:physiopathology; D019332:Endothelin-1 / Q000378:metabolism*; D005902:Glaucoma, Open-Angle / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008833:Microcirculation; D010958:Plasminogen / Q000378:metabolism*; D012720:Severity of Illness Index; D013666:Tears / Q000737:chemistry*; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D010958:Plasminogen