title: Short duration of sleep is associated with hyperleptinemia in Taiwanese adults.
abstract: BACKGROUND
  Higher plasma levels of leptin have been associated with increased cardiometabolic risk. The aim of this study was to investigate the association between short duration of sleep and hyperleptinemia in Taiwanese adults.
  
  
  METHODS
  We examined the association between duration of sleep and hyperleptinemia in 254 men and women recruited from the physical examination center at a regional hospital in southern Taiwan. Hyperleptinemia was defined as a plasma leptin level of 8.13 ng/mL and above. Short sleep duration was defined as < 6.5 h/day. Multiple logistic regression analysis was used to assess the association between short duration of sleep and hyperleptinemia.
  
  
  RESULTS
  In females, short duration of sleep (< 6.5 h/day; OR = 2.15, 95% CI = 0.99-4.78), greater hip circumference (OR = 3.00, CI = 1.13-8.78), higher percent body fat (OR = 1.75, CI = 1.07-2.95), and higher white blood cell counts (OR = 1.67, CI = 1.26-2.28) were associated with an increased risk of hyperleptinemia. In males, greater body weight was significantly associated with an increased risk of hyperleptinemia (OR = 3.55, 95% CI = 1.46-10.23). There was also a trend of association (p = 0.096) between short duration of sleep and an increased risk of hyperleptinemia (OR = 4.98, 95% CI = 0.80-42.40).
  
  
  CONCLUSIONS
  In this study of healthy Taiwanese adults, short duration of sleep was significantly associated with hyperleptinemia in women, and the association was independent of adiposity.
authors.affiliation: Department of Medical Research, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan ; Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Koo
authors.forename: Ning-Sheng
authors.initials: NS
authors.lastname: Lai
authors.forename: Jui-Kun
authors.initials: JK
authors.lastname: Chiang
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000886:Anthropometry; D015992:Body Mass Index; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology*; D016017:Odds Ratio; D018570:Risk Assessment; D012737:Sex Factors; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D020738:Leptin
keywords: Sleep duration; adiposity; gender; leptin; leptin resistance