title: Application of gene expression programming and neural networks to predict adverse events of radical hysterectomy in cervical cancer patients.
abstract: The aim of this article was to compare gene expression programming (GEP) method with three types of neural networks in the prediction of adverse events of radical hysterectomy in cervical cancer patients. One-hundred and seven patients treated by radical hysterectomy were analyzed. Each record representing a single patient consisted of 10 parameters. The occurrence and lack of perioperative complications imposed a two-class classification problem. In the simulations, GEP algorithm was compared to a multilayer perceptron (MLP), a radial basis function network neural, and a probabilistic neural network. The generalization ability of the models was assessed on the basis of their accuracy, the sensitivity, the specificity, and the area under the receiver operating characteristic curve (AUROC). The GEP classifier provided best results in the prediction of the adverse events with the accuracy of 71.96 %. Comparable but slightly worse outcomes were obtained using MLP, i.e., 71.87 %. For each of measured indices: accuracy, sensitivity, specificity, and the AUROC, the standard deviation was the smallest for the models generated by GEP classifier.
authors.affiliation: Faculty of Electrical and Computer Engineering, Rzeszow University of Technology, W. Pola 2, 35-959, Rzeszow, Poland, mkusy@prz.edu.pl.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kusy
authors.forename: Bogdan
authors.initials: B
authors.lastname: Obrzut
authors.forename: Jacek
authors.initials: J
authors.lastname: Kluska
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D008875:Middle Aged; D015233:Models, Statistical; D016571:Neural Networks, Computer; D011183:Postoperative Complications / Q000209:etiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*