title: Clinicopathologic features of CD5-positive nodal marginal zone lymphoma.
abstract: OBJECTIVE
  To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL).
  
  
  METHODS
  We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL.
  
  
  RESULTS
  Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months).
  
  
  CONCLUSIONS
  CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
authors.affiliation: The University of Texas MD Anderson Cancer Center, Dept of Hematopathology, Box 72, 1515 Holcombe Blvd, Houston, TX 77030; e-mail: jjaso@mdanderson.org.
authors.forename: Jesse Manuel
authors.initials: JM
authors.lastname: Jaso
authors.forename: C Cameron
authors.initials: CC
authors.lastname: Yin
authors.forename: Sa A
authors.initials: SA
authors.lastname: Wang
authors.forename: Roberto N
authors.initials: RN
authors.lastname: Miranda
authors.forename: Christine E
authors.initials: CE
authors.lastname: Jabcuga
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D018956:CD5 Antigens / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate; D013781:Texas / Q000453:epidemiology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018956:CD5 Antigens
keywords: CD5; Nodal marginal zone lymphoma