title: The relationship between defibrillation threshold and total mortality.
abstract: BACKGROUND
  The relationship between the defibrillation threshold (DFT) and total mortality is unclear.
  
  
  METHODS
  A university hospital prospectively maintained implantable defibrillator (ICD) database identified 508 patients who underwent ICD implantation and had DFT testing performed at implant. Patients were placed in one of three groups based on the implant DFT (high (≥20 J), moderate (19-11 J), or low DFT (≤10 J)).
  
  
  RESULTS
  Sixty-seven patients had a high DFT, 216 had a moderate DFT, and 225 had a low DFT. The mean left ventricular ejection fraction (LVEF) was 0.25, 0.28, and 0.30 in the high, moderate, and low DFT groups, respectively, (p = 0.04). There were significantly more patients with a subcutaneous electrode in the high DFT group (p < 0.001), more patients taking amiodarone (p < 0.001), and more patients on oral anticoagulation (p = 0.04). There were a total of 140 deaths during the follow-up period (mean 3.2 ± 1.7 years). There were 24 deaths in the high DFT group (35.8%), 62 in the moderate DFT group (28.7%), and 54 in the low DFT group (24.0%) (p = 0.05). Implant DFT was a significant predictor of mortality (p = 0.01), as was age, LVEF (p < 0.001), CAD (p = 0.01), amiodarone use (p = 0.02), and hematoma at implant (p = 0.01). An elevated DFT was an independent predictor of mortality after controlling for all significant univariate variables (p = 0.004).
  
  
  CONCLUSIONS
  A high-implant DFT predicts an adverse prognosis, even when an adequate ICD safety margin is present.
authors.affiliation: Medical College of Wisconsin, Milwaukee, WI, USA, jrubenstein@mcw.edu.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Rubenstein
authors.forename: Michael H
authors.initials: MH
authors.lastname: Kim
authors.forename: Fred
authors.initials: F
authors.lastname: Morady
authors.forename: S Adam
authors.initials: SA
authors.lastname: Strickberger
mesh_terms: D002423:Cause of Death; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control*; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D004056:Differential Threshold; D019544:Equipment Failure Analysis / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014922:Wisconsin / Q000453:epidemiology