title: Annexin A5 as a potential marker in tumors.
abstract: Annexin A5 (Anxa5) promotes pancreatic adenocarcinoma, sarcoma, tumorigenesis and progression of breast cancer and prostate cancer stem cells. It is involved with metastasis, invasion and development of squamous cell carcinoma, and facilitates nodal progression of bladder cancer and angiogenesis and progression of glioma. Anxa5 de-regulation is associated with drug resistance in nasopharyngeal carcinoma and gastric cancer. Although Anxa5 protein up-regulation promotes cervical cancer progression, it is markedly suppressed in cervical carcinoma cells. Anxa5 is negatively correlated with thyroid cancer malignancy. In this review, we explore the mechanisms of Anxa5 action in tumors. Anxa5 could be a predictive biomarker for tumor development, metastasis and invasion, and be of diagnostic, prognostic and therapeutic significance in cancer.
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
authors.forename: Boya
authors.initials: B
authors.lastname: Peng
authors.forename: Chunmei
authors.initials: C
authors.lastname: Guo
authors.forename: Hongwei
authors.initials: H
authors.lastname: Guan
authors.forename: Shuqing
authors.initials: S
authors.lastname: Liu
authors.forename: Ming-Zhong
authors.initials: MZ
authors.lastname: Sun
mesh_terms: D017304:Annexin A5 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy
chemical_list: D017304:Annexin A5; D014408:Biomarkers, Tumor
keywords: Annexin A5; Drug resistance; Malignancy; Tumor