title: BDNF signaling is necessary for the antidepressant-like effect of naringenin.
abstract: Previous studies in our laboratory have demonstrated that naringenin produced antidepressant-like action in tail suspension test (TST). However, the underlying mechanisms involved in neurotrophin system by which naringenin works have not been investigated. The present study extends earlier works on the role of brain-derived neurotrophic factor (BDNF) in regulating the antidepressant-like actions of naringenin in chronic unpredictable mild stress (CUMS). We showed that a 21-day regimen with naringenin reversed the decreased sucrose preference in sucrose preference test (SPT) and the prolonged first feeding latency in novelty-suppressed feeding test (NSFT), without affecting home-cage feeding consumption. In addition, we also found that naringenin promoted BDNF expression in the hippocampus but not in the frontal cortex in both non-stressed and CUMS mice. Moreover, the antidepressant-like effect of naringenin in SPT and NSFT induced by naringenin administration were totally abolished by K252a, an inhibitor of BDNF receptor tropomyosin-related kinase receptor B (TrkB). In conclusion, our findings suggest that the antidepressant-like effect of naringenin may be mediated, at least in part, by the activation of BDNF signaling in the hippocampus.
authors.affiliation: Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China. Electronic address: litao.yi@yahoo.com.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Yi
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Liu
authors.initials: L
authors.lastname: Luo
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Geng
authors.forename: Yue
authors.initials: Y
authors.lastname: Tang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xia
authors.forename: Di
authors.initials: D
authors.lastname: Wu
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002227:Carbazoles / Q000494:pharmacology; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D044950:Flavanones / Q000627:therapeutic use*; D005508:Food Deprivation; D005518:Food Preferences / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D026121:Indole Alkaloids / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015398:Signal Transduction / Q000187:drug effects*; D013315:Stress, Psychological / Q000188:drug therapy*; D013395:Sucrose / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D015854:Up-Regulation / Q000187:drug effects*; D014868:Water Deprivation
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D002227:Carbazoles; D004791:Enzyme Inhibitors; D044950:Flavanones; D026121:Indole Alkaloids; D013549:Sweetening Agents; D013395:Sucrose; C049985:staurosporine aglycone; C005273:naringenin
keywords: BDNF; Brain-derived neurotrophic factor (BDNF); CUMS; Chronic unpredictable mild stress; Depression; HPA; M-MLV; Moloney Murine Leukemia Virus; NSFT; Naringenin; SPT; TST; TrkB; brain-derived neurotrophic factor; chronic unpredictable mild stress; hypothalamic–pituitary–adrenal; novelty-suppressed feeding test; sucrose preference test; tail suspension test; tropomyosin-related kinase receptor B