title: Electropolymerized fluorinated aniline-based fiber for headspace solid-phase microextraction and gas chromatographic determination of benzaldehyde in injectable pharmaceutical formulations.
abstract: In this study, a simple method was developed and validated to detect trace levels of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction coupled with gas chromatography-flame ionization detector. Polyaniline was electrodeposited on a platinum wire in trifluoroacetic acid solvent by cyclic voltammetry technique. This fiber shows high thermal and mechanical stability and high performance in extraction of benzaldehyde. Extraction and desorption time and temperature, salt effect and gas chromatography parameters were optimized as key parameters. At the optimum conditions, the fiber shows good linearity between peak area ratio of benzaldehyde/3-chlorobenzaldehyde and benzaldehyde concentration in the range of 50-800 ng/mL with percent relative standard deviation values ranging from 0.75 to 8.64% (n = 3). The limits of quantitation and detection were 50 and 16 ng/mL, respectively. The method has the requisite selectivity, sensitivity, accuracy and precision to assay benzaldehyde in injectable pharmaceutical dosage forms.
authors.affiliation: Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran alimohammadi@tums.ac.ir.
authors.forename: Ali
authors.initials: A
authors.lastname: Mohammadi
authors.affiliation: Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mohammadi
authors.affiliation: Department of Engineering Science, College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Abdolmajid
authors.initials: A
authors.lastname: Bayandori Moghaddam
authors.affiliation: Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Vahideh
authors.initials: V
authors.lastname: Masoumi
authors.affiliation: Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Roderick B
authors.initials: RB
authors.lastname: Walker
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001547:Benzaldehydes / Q000032:analysis*; D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005410:Flame Ionization; D054879:Halogenation; D057230:Limit of Detection; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D052617:Solid Phase Microextraction / Q000295:instrumentation* / Q000379:methods*; D012997:Solvents; D013696:Temperature
chemical_list: D000814:Aniline Compounds; D001547:Benzaldehydes; D004364:Pharmaceutical Preparations; D012997:Solvents; C416807:polyaniline; C023650:aniline; C032175:benzaldehyde