title: T1 mapping in the rat myocardium at 7 tesla using a modified CINE inversion recovery sequence.
abstract: OBJECTIVE
  To evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE-IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla.
  
  
  METHODS
  The recently published mCINE-IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations were used to study signal evolution and heart rate dependency. Gadolinium phantoms, a heart specimen and a healthy rat were used to study reproducibility. Two cryo-infarcted rats were scanned to measure late gadolinium enhancement (LGE).
  
  
  RESULTS
  In the phantom reproducibility studies the T1 measurements had a maximum coefficient of variation (COV) of 1.3%. For the in vivo reproducibility the COV was below 5% in the anterior cardiac segments. In simulations with phantoms and specimens, a heart rate dependency of approximately 0.5 ms/bpm was present. The T1 maps of the cryo-infarcted rats showed a clear lowering of T1 in de LGE region.
  
  
  CONCLUSIONS
  The results show that mCINE-IR is highly reproducible and that the sensitivity allows detecting T1 changes in the rat myocardium.
authors.affiliation: Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Henk
authors.initials: H
authors.lastname: Smit
authors.forename: Ruben Pellicer
authors.initials: RP
authors.lastname: Guridi
authors.forename: Jamal
authors.initials: J
authors.lastname: Guenoun
authors.forename: Dirk H J
authors.initials: DH
authors.lastname: Poot
authors.forename: Gabriela N
authors.initials: GN
authors.lastname: Doeswijk
authors.forename: Matteo
authors.initials: M
authors.lastname: Milanesi
authors.forename: Monique R
authors.initials: MR
authors.lastname: Bernsen
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: Krestin
authors.forename: Stefan
authors.initials: S
authors.lastname: Klein
authors.forename: Gyula
authors.initials: G
authors.lastname: Kotek
mesh_terms: D000465:Algorithms; D000818:Animals; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: CINE inversion recovery; T1 estimation; delayed enhancement; rat cardiac T1