title: Preparation and characterization of nebivolol nanoparticles using Eudragit® RS100.
abstract: Nebivolol, a beta-blocker, has been widely used for the treatment of hypertension and cardiovascular diseases; but has drawbacks like poor solubility and bioavailability requiring frequent dosing. The present study attempts to overcome these issues through nanoparticulate delivery system using widely used carrier Eudragit(®) RS100. The solvent evaporation (single emulsion) technique was used for developing nanoparticles. The impact of formulation and process variables on particle size and entrapment efficiency was studied to optimize the formulation. The physico-chemical characterization confirmed the particle size in nano range with smooth and spherical morphology. Further, Fourier transforms infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) studies confirm compatibility of drug-polymer combination. The in vitro drug release study of the prepared nanoparticles showed prolongation of drug release with reduced burst release in comparison with pure drug powder.
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India.
authors.forename: Utpal
authors.initials: U
authors.lastname: Jana
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India.
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Mohanty
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India.
authors.forename: Prabal Kumar
authors.initials: PK
authors.lastname: Manna
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India. Electronic address: gpmohanta@hotmail.com.
authors.forename: Guru Prasad
authors.initials: GP
authors.lastname: Mohanta
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry; D004983:Ethanolamines / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D000068577:Nebivolol; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001578:Benzopyrans; D004337:Drug Carriers; D004983:Ethanolamines; D011109:Polymethacrylic Acids; D000068577:Nebivolol; C038300:methylmethacrylate-methacrylic acid copolymer
keywords: Eudragit(®) RS100; Nanoparticles; Nebivolol; Poorly soluble