title: Paraneoplastic leukemoid reaction in solid tumors.
abstract: Leukemoid reaction is defined as leucocytosis >50,000/μL. When it occurs in association with a malignancy, and infection or leukemia has been ruled out, it is termed as paraneoplastic leukemoid reaction. A patient presented with fatigue, generalized weakness, and abdominal distension and was incidentally noted to have a white blood cell count of 139,000/μL. Leukemia was ruled out by peripheral smear and flow cytometry. Computed tomography-guided biopsy of thickened omentum revealed poorly differentiated metastatic carcinoma. He died 3 days after admission with a peak white blood cell count of 180,000/μL. Previous reports and pathophysiology of paraneoplastic leukemoid reaction are reviewed.
authors.affiliation: *Department of Internal Medicine, University of Nebraska Medical Center, Omaha †Department of Pathology, Saint Francis Medical Center ‡Internal Medical Associates of Grand Island, Grand Island, NE.
authors.forename: Subhankar
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Brent
authors.initials: B
authors.lastname: Keenportz
authors.forename: Suzette
authors.initials: S
authors.lastname: Woodward
authors.forename: Jay
authors.initials: J
authors.lastname: Anderson
authors.forename: David
authors.initials: D
authors.lastname: Colan
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D007955:Leukemoid Reaction / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000150:complications*; D009852:Omentum; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D011859:Radiography