title: Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease.
abstract: Several large-scale meta-GWAS identified significant association between SNP rs17465637 in the MIA3 gene and coronary artery disease (CAD) in the European ancestry populations. However, three follow-up replication studies in the Chinese populations yielded inconsistent results. In order to unequivocally determine whether SNP rs17465637 is associated with CAD, we performed an independent case control association study in the Chinese Han population and a follow-up large scale meta-analysis for SNP rs17465637. Our study included 2503 CAD patients and 2920 non-CAD controls of the Chinese Han origin. A significant association was found between SNP rs17465637 and CAD (P = 0.01, OR = 1.11). Meta-analysis included 7263 CAD patients and 8347 controls combined from five Asian populations. The association between SNP rs17465637 and CAD became highly significant (P = 4.97 × 10(-5), OR = 1.11). Similar analysis also identified significant association between SNP rs17465637 and MI (2424 cases vs. 6,536controls; P = 5.00 × 10(-3), OR = 1.10). We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations.
authors.affiliation: Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Li
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Huang
authors.forename: Dan
authors.initials: D
authors.lastname: Yin
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Chengqi
authors.initials: C
authors.lastname: Xu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Sisi
authors.initials: S
authors.lastname: Li
authors.forename: Shanshan
authors.initials: S
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Xiong
authors.forename: Yuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhu
authors.forename: Zhenhong
authors.initials: Z
authors.lastname: Su
authors.forename: Bisheng
authors.initials: B
authors.lastname: Zhou
authors.forename: Yuting
authors.initials: Y
authors.lastname: Zhang
authors.forename: Longfei
authors.initials: L
authors.lastname: Wang
authors.forename: Le
authors.initials: L
authors.lastname: Chang
authors.forename: Chaoping
authors.initials: C
authors.lastname: Xu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Tie
authors.initials: T
authors.lastname: Ke
authors.forename: Xiang
authors.initials: X
authors.lastname: Ren
authors.forename: Xiang
authors.initials: X
authors.lastname: Cheng
authors.forename: Yanzong
authors.initials: Y
authors.lastname: Yang
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Liao
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Qing K
authors.initials: QK
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C497396:ARNT protein, human; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator