title: Longitudinal evaluation using FP-CIT in patients with parkinsonism.
abstract: OBJECTIVE
  To assess a group of patients with parkinsonism using serial studies with FP-CIT, basically the initial false negative results.
  
  
  METHODS
  Restrospective study of 92 patients (55 men and 37 women) who had undergone 2 different FP-CIT studies because of discrepancies between study results and clinical progression. The mean elapsed time between the studies was 26 months (SD: 6). We performed a semi-quantitative study using the patient's clinical history and the available literature to analyse discrepant cases with a normal initial study and subsequent pathological findings.
  
  
  RESULTS
  A total of 184 studies were completed for 92 patients; 11 of those 92 showed discrepancies between initial and subsequent studies. Among the 11 discrepant cases, 7 showed a normal initial study and pathological findings at a later date. Analysis of the predominant clinical features that might explain this behaviour revealed that 4 of these 7 subjects presented tremor-dominant parkinsonism. Regarding the rest, 1 presented early stage parkinsonism and was treated with antidopaminergic agents; 1 was classified as probable multisystem atrophy type C, and the third showed clinical signs of atypical parkinsonism without any causes of those signs being identified.
  
  
  CONCLUSIONS
  Serial FP-CIT studies are unnecessary in the large majority of cases, but they may be justifiable in certain clinical situations.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Virgen de la Victoria», Málaga, España. Electronic address: mariad.martinezvalle.sspa@juntadeandalucia.es.
authors.forename: M D
authors.initials: MD
authors.lastname: Martínez-Valle Torres
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «San Cecilio», Granada, España.
authors.forename: S J
authors.initials: SJ
authors.lastname: Ortega Lozano
authors.affiliation: Servicio de Neurología, Hospital Universitario «Virgen de la Victoria», Málaga, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez Heredia
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Virgen de la Victoria», Málaga, España.
authors.forename: T
authors.initials: T
authors.lastname: Amrani Raissouni
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Virgen de la Victoria», Málaga, España.
authors.forename: E
authors.initials: E
authors.lastname: Ramos Moreno
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Virgen de la Victoria», Málaga, España.
authors.forename: P
authors.initials: P
authors.lastname: Moya Espinosa
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario «Virgen de la Victoria», Málaga, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Jiménez-Hoyuela
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D020329:Essential Tremor / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: Dopamine transporters; False negatives; Falsos negativos; I123-Ioflupane; I123-Ioflupano; Parkinsonism; Parkinsonismo; Transportadores de dopamina