title: [Prognosis assessment of alcoholic liver disease: how and why?].
abstract: Alcoholic liver disease (ALD) causes more than 5000 deaths per year in France. Most of those deaths could be prevented by an early diagnosis, which would give the patients the opportunity to modify their alcohol consumption while liver lesions are still reversible. Hepatic histology is the main parameter that predicts morbidity and mortality in patients with ALD. Non-invasive methods such as biomarker tests (e.g. FibroTest(®) or FibroMetre A(®)) or hepatic elastography (FibroScan(®)) may allow diagnosing alcohol-induced liver lesion without systematic biopsy. Despite promising preliminary results, those methods are not validated yet in ALD. A validation of non-invasive methods for ALD could allow a large screening of the severe forms of this pathology.
authors.affiliation: Hôpital Cochin, AP-HP, unité d'hépatologie et d'addictologie, 75014 Paris, France; Institut d'histoire et de philosophie des sciences et des techniques, 75006 Paris, France. Electronic address: jean-baptiste.trabut@cch.aphp.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Trabut
authors.affiliation: Hôpital Cochin, AP-HP, unité d'hépatologie et d'addictologie, 75014 Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Thépot
authors.affiliation: Hôpital Cochin, laboratoire d'anatomie pathologie, université Paris Descartes, 75014 Paris, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Terris
authors.affiliation: Hôpital Cochin, AP-HP, unité d'hépatologie et d'addictologie, 75014 Paris, France; Inserm U1016, université Paris Descartes, 75014 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sogni
authors.affiliation: Inserm, département de l'alcool et des addictions, 75013 Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Nalpas
authors.affiliation: Hôpital Cochin, AP-HP, unité d'hépatologie et d'addictologie, 75014 Paris, France; Inserm U1016, université Paris Descartes, 75014 Paris, France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
mesh_terms: D015415:Biomarkers; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis*; D008297:Male; D011379:Prognosis
chemical_list: D015415:Biomarkers