title: Double-blind, randomized, controlled clinical trial of the effects of diosmectite and basic fibroblast growth factor paste on the treatment of minor recurrent aphthous stomatitis.
abstract: OBJECTIVE
  This study investigated the effectiveness and safety of topical application of diosmectite (DS) and basic fibroblast growth factor (bFGF) paste in the treatment of minor recurrent aphthous stomatitis.
  
  
  METHODS
  Four pastes, containing bFGF and DS, DS alone, bFGF alone, and vehicle only, were consecutively applied 4 times per day for 5 days. Pain levels and the amount of ulcer amelioration were evaluated.
  
  
  RESULTS
  A total of 129 participants completed the study. DS+bFGF paste released bFGF continuously and significantly lowered ulcer pain scores (P < .05 for days 3, 4, 5, and 6) compared with the other pastes. The ulcer size was significantly reduced (P < .05 for days 2, 4, and 6) in the DS+bFGF paste group compared with the other groups. No obvious adverse drug effects were observed.
  
  
  CONCLUSIONS
  DS+bFGF paste was effective in alleviating ulcer pain and promoting healing without significant side effects in the treatment of minor recurrent aphthous stomatitis.
authors.affiliation: Department of Stomatology, First People's Hospital of Chenzhou and University of South China, Chenzhou, Hunan, China; Institute of Translation Medicine, University of South China, Chenzhou, Hunan, China. Electronic address: jxw0927@yahoo.com.cn.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Lu
authors.forename: Shou-Kang
authors.initials: SK
authors.lastname: Yang
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Sun
mesh_terms: D000287:Administration, Topical; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009824:Ointments; D012008:Recurrence; D017640:Silicates / Q000008:administration & dosage / Q000627:therapeutic use*; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D009824:Ointments; D017640:Silicates; D016222:Fibroblast Growth Factor 2; C033214:Smectite