title: MRI biosensor for lead detection based on the DNAzyme-induced catalytic reaction.
abstract: A MRI biosensor for sensitive and specific detection of lead ions (Pb(2+)) was developed based on DNAzyme-induced cleavage of magnetic nanoparticles (MNPs). A low limit of detection (LOD) of 0.05 ng mL(-1) was obtained. This biosensor has the potential to serve as a general platform for the detection of heavy metal ions.
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University , Wuxi, JiangSu 214122, People's Republic of China.
authors.forename: Liguang
authors.initials: L
authors.lastname: Xu
authors.forename: Honghong
authors.initials: H
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Libing
authors.initials: L
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Kuang
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Xu
mesh_terms: D015374:Biosensing Techniques; D002384:Catalysis; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D007477:Ions / Q000737:chemistry; D007854:Lead / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry
chemical_list: D021881:DNA, Catalytic; D007477:Ions; D058185:Magnetite Nanoparticles; D007854:Lead