title: Efficacy of a Dermoxen® lenitiva for pruritus genitalis in a randomized, double blind trial.
abstract: BACKGROUND
  Pruritus can be defined as an unpleasant cutaneous sensation associated with the immediate desire to scratch. In particular external intimate zone could be hit by pruritus genitalis because of several reasons (bacterial infection, fungal infection, stress, bad intimate behavior, synthetic intimate clothes).
  
  
  OBJECTIVE
  The aim of the study was to compare the efficacy of Dermoxen® Lenitiva cream versus a methylprednisolone aceponate 0.1% based cream in treating pruritus of the external genitalia.
  
  
  METHODS
  Independent, randomized, double-blind, controlled trial in two University affiliated Italian Hospitals. 80 women, affected by aspecific pruritus genitalis with negative vaginal swab for bacterial or fungal infections or other pathogenic causes of itching, were selected and blindly treated by Dermoxen® Lenitiva cream or methylprednisolone aceponate 0.1% based cream. The main outcome measures were: the reduction of sensation of pruritus, evaluated by a visual analog scale (VAS) pain score, and improvement of intimate wellness sensation, and comfort during sexual intercourse, frequency and severity of adverse reactions.
  
  
  RESULTS
  Significant reduction of itching sensation was verified for each treatment.
  
  
  CONCLUSIONS
  Based on our results, DermoXen® Lenitiva vaginal cream showed efficacy so as methylprednisolone aceponate 0.1% based cream for itching treatment on external female genitalia and improved intimate comfort and comfort in sexual intercourse.
authors.affiliation: Research and Development, Ekuberg Pharma S.r.l., Italy. davide.carati@ekubergpharma.com  
authors.forename: D
authors.initials: D
authors.lastname: Carati
authors.forename: M
authors.initials: M
authors.lastname: Guido
authors.forename: A
authors.initials: A
authors.lastname: Malvasi
authors.forename: A
authors.initials: A
authors.lastname: Zizza
authors.forename: A
authors.initials: A
authors.lastname: Tinelli
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009824:Ointments; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy*
chemical_list: D009824:Ointments; D010936:Plant Extracts; C078007:methylprednisolone aceponate; D008775:Methylprednisolone