title: [Glycosylation of autoantibodies in autoimmunes diseases].
abstract: Protein glycosylation is one of the most common post-translational modifications, involved in the well described protein biosynthesis process. Protein glycosylation seems to play a major role in the pathogenesis of auto-immune diseases. Herein are described the main alterations of autoantibody glycosylation associated with autoimmunes diseases such as rheumatoid arthritis, IgA glomerulonephritis, Schoenlein-Henoch purpura, Sjögren's syndrome, systemic scleroderma, systemic lupus erythematosus, myasthenia gravis and granulomatosis with polyangiitis (Wegener). Molecular identification of altered immunoglobulin glycosylation could lead to a better understanding of the pathogenesis of those diseases, might allow an evaluation of their biological activity and could even be a new therapeutic target.
authors.affiliation: Médecine interne et maladies multi-organiques de l'adulte, centre de compétence pour « maladie auto-immunes rares », université Montpellier I, CHRU Saint-Éloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.
authors.forename: R
authors.initials: R
authors.lastname: Goulabchand
authors.forename: F
authors.initials: F
authors.lastname: Batteux
authors.forename: P
authors.initials: P
authors.lastname: Guilpain
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D000939:Epitopes / Q000378:metabolism; D006031:Glycosylation; D014890:Granulomatosis with Polyangiitis / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D056747:Immunomodulation
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D016756:Immunoglobulins, Intravenous
keywords: Auto-anticorps; Autoantibodies; Autoimmune diseases; Glycosylation; Immunoglobulines; Immunoglobulins; Maladies auto-immunes; Sialylation