title: Mechanically tissue-like elastomeric polymers and their potential as a vehicle to deliver functional cardiomyocytes.
abstract: One of the major challenges in the field of biomaterials engineering is the replication of the non-linear elasticity observed in soft tissues. In the present study, non-linearly elastic biomaterials were successfully fabricated from a chemically cross-linked elastomeric poly(glycerol sebacate) (PGS) and thermoplastic poly(L-lactic acid) (PLLA) using the core/shell electrospinning technique. The spun fibrous materials, containing a PGS core and PLLA shell, demonstrated J-shaped stress-strain curves, and having ultimate tensile strength, rupture elongation, and stiffness constants respectively comparable to muscle tissue properties. In vitro evaluations also showed that PGS/PLLA fibrous biomaterials possess excellent biocompatibility, capable of supporting human stem-cell-derived cardiomyocytes over several weeks in culture. Therefore, the core/shell electrospun elastomeric materials provide a new potential scaffold to support cells in the therapy of a wide range of soft tissues exposed to cyclic deformation, such as tendon, ligament, cardiac or smooth muscle and lung epithelium.
authors.affiliation: Department of Materials Engineering and Monash Centre of Electron Microscope, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiya
authors.initials: X
authors.lastname: Fang
authors.forename: George A
authors.initials: GA
authors.lastname: Thouas
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Cook
authors.forename: Donald F
authors.initials: DF
authors.lastname: Newgreen
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003651:Decanoates / Q000737:chemistry*; D020724:Elastomers / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000187:drug effects; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013314:Stress, Mechanical; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003651:Decanoates; D020724:Elastomers; D011091:Polyesters; D011108:Polymers; C469892:poly(glycerol-sebacate); D019344:Lactic Acid; C033616:poly(lactide); D005990:Glycerol
keywords: Cardiomyocyte; Core/shell electrospinning; Elastomer; Poly(glycerol sebacate) fibre