title: Thermoresponsive dendrimers based on oligoethylene glycols: design, synthesis and cytotoxic activity against MCF-7 breast cancer cells.
abstract: Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone were efficiently synthesized from tetrabromohydroquinone and three different oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement at different temperatures for 0.25 wt% of aqueous solutions from D1, D2 and D3. The cytotoxicity of the prepared dendrimers was tested against MCF-7 breast cancer cells. All tested dendrimers showed considerable results, where D2 dendrimer gave the best result; it showed cytotoxicity against MCF-7 cell line with IC₅₀ of 1.07 μg/mL and resistant fraction equals 1.97%, the other two dendrimers showed a modest cytotoxic profile.
authors.affiliation: Chemistry Department, Polymer Lab. 122, Faculty of Science, Assiut University, PB 71516, Assiut, Egypt. Electronic address: manoush00@yahoo.com.
authors.forename: Mona A
authors.initials: MA
authors.lastname: Abdel-Rahman
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Al-Abd
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry; D061986:MCF-7 Cells; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: C509877:2,3,5,6-tetrabromohydroquinone; D000970:Antineoplastic Agents; D050091:Dendrimers; D006873:Hydroquinones; D011092:Polyethylene Glycols
keywords: Cytotoxicity; Synthesis; Tetrabromohydroquinone; Thermoresponsive dendrimers; Water-soluble dendrimers