title: Fennel-like nanoaggregates based on polysaccharide derivatives and their application in drug delivery.
abstract: Biodegradable polymeric nanoparticles, which hold hierarchical morphologies, are of importance for controlled drug delivery. In this work, nanoparticles with fennel-like morphology were prepared from graft copolymers of hydroxyethylcellulose and poly(p-dioxane). The effect of microstructure parameters on the morphological transition of the nano-aggregates was studied and the nanoparticles were investigated as a carrier of hydrophobic drug. The morphology and drug release property of the nanoparticles were found to be related with the degree of substitution and molecular weight of graft chain of the copolymer.
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China. Electronic address: songfei520@gmail.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Shi
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
authors.forename: Xue-Ting
authors.initials: XT
authors.lastname: Dong
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Han
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China. Electronic address: xiuliwang1@163.com.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
authors.forename: Si-Chong
authors.initials: SC
authors.lastname: Chen
authors.affiliation: Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China.
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Wang
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D007052:Ibuprofen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D004146:Dioxanes; D011108:Polymers; D002482:Cellulose; C002283:hydroxyethylcellulose; C025223:1,4-dioxane; D007052:Ibuprofen
keywords: Controlled release; Fennel-like morphology; Hydroxyethylcellulose; Ibuprofen; Poly(p-dioxane)