title: Radiation-induced gliomas in 2 pediatric patients with neurofibromatosis type 1: case study and summary of the literature.
abstract: Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes patients to the formation of sporadic tumors and also increases the risk of radiation-induced malignancies. The most commonly described radiation-induced tumor in NF1 patients is a malignant peripheral nerve sheath tumor. We present 2 children with NF1 who received radiation therapy and subsequently developed high-grade gliomas. We then review the current literature on radiation-induced tumors in NF1 patients. Although radiation may be the most appropriate therapy in specific situations for children with NF1, the secondary tumor risk should be carefully considered.
authors.affiliation: Departments of *Neuro-Oncology †Radiology, Children's Hospital Colorado, Aurora ‡Department of Radiation Oncology, University of Colorado, Denver, CO.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Madden
authors.forename: Sarah Z
authors.initials: SZ
authors.lastname: Rush
authors.forename: Nicholas
authors.initials: N
authors.lastname: Stence
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Foreman
authors.forename: Arthur K
authors.initials: AK
authors.lastname: Liu
mesh_terms: D001932:Brain Neoplasms / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005910:Glioma / Q000209:etiology*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000532:radiotherapy*