title: Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study.
abstract: OBJECTIVE
  To develop the missing link between hyperuricemia and hypertension.
  
  
  METHODS
  The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department. Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee. Totally 205 newly diagnosed and untreated essential hypertensive cases and age-sex matched normotensive controls were enrolled in the study. The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled. Uric acid levels in all participants were analyzed.
  
  
  RESULTS
  Renal function between newly diagnosed hypertensive cases and normotensive healthy controls were adjusted. The mean serum uric acid observed in newly diagnosed hypertensive cases and in normotensive healthy controls were (290.05±87.05) μmol/L and (245.24±99.38) μmol/L respectively. A total of 59 (28.8%) participants of cases and 28 (13.7%) participants of controls had hyperuricemia (odds ratio 2.555 (95% CI: 1.549-4.213), P<0.001).
  
  
  CONCLUSIONS
  The mean serum uric acid levels and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.
authors.affiliation: Department of Biochemistry, Manipal College of Medical Sciences (MCOMS), Manipal Teaching Hospital (MTH), Pokhara, Nepal. Electronic address: bibekclb@yahoo.com.
authors.forename: Bibek
authors.initials: B
authors.lastname: Poudel
authors.forename: Binod Kumar
authors.initials: BK
authors.lastname: Yadav
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.forename: Bharat
authors.initials: B
authors.lastname: Jha
authors.forename: Kanak Bahadur
authors.initials: KB
authors.lastname: Raut
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology*; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid
keywords: Hyperuricemia; Joint National Committee; Newly diagnosed hypertension; Serum uric acid