title: Antimutagenic activity of wheat polypeptides in human cells exposed to cadmium chloride.
abstract: Antimutagenic effects of polypeptides isolated from Triticum kiharae wheat plantule extracts have been studied on human cells exposed to cadmium chloride. The most effective polypeptide Tk-AMP-BP β -purothionin exhibited higher antimutagenic activity than wheat water extract and another peptide isolated from the same wheat species, Tk-AMP-γ 2 defensin; it also produced a pronounced antioxidant effect. This polypeptide can be used as a preventive agent for reducing the mutagenic potential of some environmental pollutants and for correction of human diseases associated with the defense system defects.
authors.affiliation: N. I. Vavilov Institute of General Genetics, the Russian Academy of Sciences, Moscow, Russia. Zasukhina@vigg.ru.
authors.forename: G D
authors.initials: GD
authors.lastname: Zasukhina
authors.forename: I M
authors.initials: IM
authors.lastname: Vasilyeva
authors.forename: I A
authors.initials: IA
authors.lastname: Kadnikov
authors.forename: M V
authors.initials: MV
authors.lastname: Voronin
authors.forename: T I
authors.initials: TI
authors.lastname: Odintsova
authors.forename: T V
authors.initials: TV
authors.lastname: Korostileva
authors.forename: V A
authors.initials: VA
authors.lastname: Pukhalskii
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D019256:Cadmium Chloride / Q000009:adverse effects; D002478:Cells, Cultured; D023082:Defensins / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D014908:Triticum / Q000737:chemistry*
chemical_list: D023181:Antimicrobial Cationic Peptides; D016587:Antimutagenic Agents; D000975:Antioxidants; D023082:Defensins; D010936:Plant Extracts; D010940:Plant Proteins; C016085:purothionin; D019256:Cadmium Chloride