title: Supraglottic immunoglobulin-G4 related plasma cell granuloma: case report and literature review.
abstract: BACKGROUND
  Granuloma of the upper aerodigestive tract is a rare presentation of immunoglobulin-G4 (IgG4)-related disease. Since the disease process was defined in 2003, only 2 cases affecting the laryngopharynx have been reported in the literature.
  
  
  RESULTS
  A 62-year-old white man presented with persistent productive cough of brown sputum, globus symptoms, dysphagia, odynophagia, dysphonia, otalgia, and general malaise over a period of 2 months. Investigations revealed IgG4-positive plasma cell granuloma of the supraglottic region. This was successfully treated with oral corticosteroids.
  
  
  CONCLUSIONS
  Because IgG4 testing is not performed routinely, management recommendations have been poorly defined. We reviewed the literature and discuss herein the clinical characteristics, pathology, diagnosis, and management. The authors theorize that IgG4-related disease involving the larynx and pharynx may be more common than suggested by the paucity of reported cases.
authors.affiliation: Department of Otolaryngology, Monash Health, Melbourne, Victoria, Australia.
authors.forename: Jeremy F
authors.initials: JF
authors.lastname: Khoo
authors.forename: Michael
authors.initials: M
authors.lastname: Batt
authors.forename: Paul
authors.initials: P
authors.lastname: Stimpson
authors.forename: Adnan
authors.initials: A
authors.lastname: Safdar
mesh_terms: D000284:Administration, Oral; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005931:Glottis / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006104:Granuloma, Plasma Cell / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D007074:Immunoglobulin G
keywords: inflammatory myofibroblastic tumor; inflammatory pseudotumor; laryngeal diseases; plasma cell granuloma; serum immunoglobulin (Ig)G4 concentrations