title: Photodynamic hyperthermal chemotherapy with indocyanine green: a novel cancer therapy for 16 cases of malignant soft tissue sarcoma.
abstract: Sixteen cases of malignant soft tissue sarcoma (STS; 10 canines and six felines) were treated with a novel triple therapy that combined photodynamic therapy, hyperthermia using indocyanine green with a broadband light source, and local chemotherapy after surgical tumor resection. This triple therapy was called photodynamic hyperthermal chemotherapy (PHCT). In all cases, the surgical margin was insufficient. In one feline case, PHCT was performed without surgical resection. PHCT was performed over an interval of 1 to 2 weeks and was repeated three to 21 times. No severe side effects, including severe skin burns, necrosis, or skin suture rupture, were observed in any of the animals. No disease recurrence was observed in seven out of 10 (70.0%) dogs and three out of six (50.0%) cats over the follow-up periods ranging from 238 to 1901 days. These results suggest that PHCT decreases the risk of STS recurrence. PHCT should therefore be considered an adjuvant therapy for treating companion animals with STS in veterinary medicine.
authors.affiliation: The United Graduated Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Onoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kawashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takayama
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ogawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D002415:Cats; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D004285:Dogs; D006979:Hyperthermia, Induced / Q000662:veterinary; D007208:Indocyanine Green / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000662:veterinary; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D007208:Indocyanine Green
keywords: PDT; cancer; chemotherapy; hyperthermia; soft tissue sarcoma