title: SLC1A2 rs3794087 does not associate with essential tremor.
abstract: A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET, we genotyped rs3794087 in a North American series consisting of 1347 patients with ET and controls. Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and patients with ET (p > 0.36). These findings therefore do not support a role for SLC1A2 rs3794087 in susceptibility to ET in the North American population. Further studies in ethnically distinct populations of patients with ET are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver British Columbia, Canada.
authors.forename: Jay P
authors.initials: JP
authors.lastname: Ross
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Sruti
authors.initials: S
authors.lastname: Rayaprolu
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver British Columbia, Canada.
authors.forename: Cecily Q
authors.initials: CQ
authors.lastname: Bernales
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto-Ortolaza
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Jay
authors.initials: J
authors.lastname: van Gerpen
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.affiliation: Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon Saskatchewan, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Rajput
authors.affiliation: Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon Saskatchewan, Canada.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Rajput
authors.affiliation: Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon Saskatchewan, Canada.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Rajput
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver British Columbia, Canada. Electronic address: carles@can.ubc.ca.
authors.forename: Carles
authors.initials: C
authors.lastname: Vilariño-Güell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020329:Essential Tremor / Q000208:ethnology* / Q000235:genetics*; D027342:Excitatory Amino Acid Transporter 2; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D050491:Glutamate Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009656:North America / Q000208:ethnology; D012307:Risk Factors
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D050491:Glutamate Plasma Membrane Transport Proteins; C493397:SLC1A2 protein, human
keywords: Association; Essential tremor; SLC1A2