title: Multivariate pattern analysis of FMRI in breast cancer survivors and healthy women.
abstract: Advances in breast cancer (BC) treatments have resulted in significantly improved survival rates. However, BC chemotherapy is often associated with several side effects including cognitive dysfunction. We applied multivariate pattern analysis (MVPA) to functional magnetic resonance imaging (fMRI) to find a brain connectivity pattern that accurately and automatically distinguishes chemotherapy-treated (C+) from non-chemotherapy treated (C-) BC females and healthy female controls (HC). Twenty-seven C+, 29 C-, and 30 HC underwent fMRI during an executive-prefrontal task (Go/Nogo). The pattern of functional connectivity associated with this task discriminated with significant accuracy between C+ and HC groups (72%, p = .006) and between C+ and C- groups (71%, p = .012). However, the accuracy of discrimination between C- and HC was not significant (51%, p = .46). Compared with HC, behavioral performance of the C+ and C- groups during the task was intact. However, the C+ group demonstrated altered functional connectivity in the right frontoparietal and left supplementary motor area networks compared to HC, and in the right middle frontal and left superior frontal gyri networks, compared to C-. Our results provide further evidence that executive function performance may be preserved in some chemotherapy-treated BC survivors through recruitment of additional neural connections.
authors.affiliation: 1 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
authors.forename: S M Hadi
authors.initials: SM
authors.lastname: Hosseini
authors.affiliation: 1 Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
authors.forename: Shelli R
authors.initials: SR
authors.lastname: Kesler
mesh_terms: D000328:Adult; D000368:Aged; D001185:Artificial Intelligence; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D002755:Choice Behavior; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D013534:Survival; D017741:Survivors
chemical_list: D010100:Oxygen