title: Serum and tissue metabolomics of head and neck cancer.
abstract: BACKGROUND
  No reliable clinical markers to diagnose early stage-disease and predict its prognosis have yet been found for squamous cell carcinoma of the head and neck (HNSCC).
  
  
  METHODS
  In the present study, the metabolomic analysis of serum and tissue samples obtained from patients with HNSCC was performed using gas chromatography/mass spectrometry.
  
  
  RESULTS
  In serum, levels of several metabolites related to the glycolytic pathway, such as glucose, were higher in patients with HNSCC, and the levels of several amino acids were lower. In contrast to sera, the levels of many metabolites related to the glycolytic pathway appeared to be lower in tumor tissues of HNSCC than in non-tumorous tissues, and the levels of several amino acids, such as valine, thyrosine, serine and methionine, were higher.
  
  
  CONCLUSIONS
  Our results demonstrate that changes in metabolite patterns are useful in assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.
authors.affiliation: Professor and Chairman. Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. nibu@med.kobe-u.ac.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Shin
authors.initials: S
authors.lastname: Nishiumi
authors.forename: Shin
authors.initials: S
authors.lastname: Nishiumii
authors.forename: Junko
authors.initials: J
authors.lastname: Kitamoto-Matsuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Koichi
authors.initials: K
authors.lastname: Morimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamashita
authors.forename: Miki
authors.initials: M
authors.lastname: Saito
authors.forename: Naoki
authors.initials: N
authors.lastname: Otsuki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Irino
authors.forename: Masakazu
authors.initials: M
authors.lastname: Shinohara
authors.forename: Masaru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nibu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D008297:Male; D055432:Metabolomics; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor
keywords: Metabolomics; amino acid; glycolytic pathway; head and neck cancer; serum; tissue