title: Clinical trials of viral therapy for malignant gliomas.
abstract: Despite recent scientific advances in the understanding of the biology of malignant gliomas, there has been little change in the overall survival for this devastating disease. New and innovative treatments are under constant investigation. Starting in the 1990s, there was an interest in using viral therapeutics for the treatment of malignant gliomas. Multiple strategies were pursued, including oncolytic viral therapy, enzyme/pro-drug combinations and gene transfer with viral vectors. Multiple Phase I and II trials demonstrated the safety of these techniques, but clinically showed limited efficacy. However, this led to a better understanding of the pitfalls of viral therapy and encouraged the development of new approaches and improved delivery methods. Here we review the prior and ongoing clinical trials of viral therapy for gliomas, and discuss how novel strategies are currently being utilized in clinical trials.
authors.affiliation: Department of Neurosciences, Moores Cancer Center, Translational Neuro-Oncology Laboratories, 3855 Health Sciences Dr. #0819, UC San Diego, La Jolla, CA, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Piccioni
authors.forename: Santosh
authors.initials: S
authors.lastname: Kesari
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000628:therapy*; D002986:Clinical Trials as Topic; D015316:Genetic Therapy; D005822:Genetic Vectors; D005910:Glioma / Q000235:genetics / Q000628:therapy*; D006801:Humans; D050130:Oncolytic Virotherapy; D014780:Viruses / Q000235:genetics*