title: Presence of keratin-specific antibody-forming cells in palatine tonsils of patients with pustulosis palmaris et plantaris (PPP) and its correlation with prognosis after tonsillectomy.
abstract: CONCLUSIONS
  Keratin-specific immune responses in tonsils may be associated with the pathogenesis of pustulosis palmaris et plantaris (PPP). Evaluation of keratin-specific immune responses in tonsils might be useful to predict the effectiveness of tonsillectomy for patients with PPP.
  
  
  OBJECTIVE
  The aim of the present study was to clarify the role of keratin-specific immune responses in the pathogenesis of PPP in tonsils. It has been reported that anti-keratin antibodies in serum were higher in patients with PPP and decreased after tonsillectomy, indicating that anti-keratin antibodies might be generated in tonsils.
  
  
  METHODS
  In order to demonstrate the presence of keratin-specific immune responses in tonsils, the numbers of keratin-specific antibody-forming cells (AFCs) in tonsillar and peripheral blood lymphocytes were examined by enzyme-linked immunospot assay. The prognosis of PPP was compared after tonsillectomy.
  
  
  RESULTS
  The numbers of keratin-specific IgM and IgG AFCs in tonsils and of IgG AFCs in peripheral blood were significantly increased in patients with PPP. The numbers of keratin-specific IgG AFCs in peripheral blood correlated positively with tonsil and serum IgG antibodies specific to keratin. Our data show that a good prognosis in patients with PPP depended on the numbers of keratin-specific IgG and IgM AFCs in peripheral blood and the levels of keratin-specific IgG antibodies in serum being significantly decreased 6 months after tonsillectomy.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Ohori
authors.forename: Yukari
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kurono
mesh_terms: D000293:Adolescent; D000328:Adult; D000921:Antibody-Producing Cells; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007633:Keratins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D011565:Psoriasis / Q000097:blood / Q000276:immunology* / Q000601:surgery; D014068:Tonsillectomy; D055815:Young Adult
chemical_list: D007633:Keratins