title: Prevalence of unruptured cerebral aneurysms in Chinese adults aged 35 to 75 years: a cross-sectional study.
abstract: BACKGROUND
  The reported prevalence of unruptured cerebral aneurysms (UCAs) varies widely.
  
  
  OBJECTIVE
  To measure the prevalence of UCAs by using 3-dimensional time-of-flight magnetic resonance angiography in adults aged 35 to 75 years.
  
  
  METHODS
  Cross-sectional study done between June 2007 and June 2011.
  
  
  METHODS
  Two communities chosen at random from 2 districts (1 urban and 1 suburban) in Shanghai, China.
  
  
  METHODS
  4813 adults aged 35 to 75 years.
  
  
  METHODS
  Three-dimensional time-of-flight magnetic resonance angiography, interpreted by 3 observers blinded to the participants' information, was used to identify the location and size of UCAs and to estimate the overall, age-specific, and sex-specific prevalence.
  
  
  RESULTS
  369 UCAs were found in 336 participants (130 men and 206 women); 4477 participants had no evidence of UCAs. The prevalence was 7.0% overall (95% CI, 6.3% to 7.7%), with 5.5% for men (CI, 4.6% to 6.4%) and 8.4% for women (CI, 7.3% to 9.5%). The overall prevalence of UCAs was higher in women than in men (P < 0.001) and peaked at ages 55 to 64 years in men and women. The UCAs were mostly located in the internal carotid artery (81%), and 90.2% had a maximum diameter less than 5 mm. Mean diameter was larger in women than in men (3.7 mm vs. 3.2 mm; P < 0.009).
  
  
  CONCLUSIONS
  Participants were from 2 communities selected from 2 districts in Shanghai, and adults older than 75 years were not studied.
  
  
  CONCLUSIONS
  The overall prevalence of UCAs was 7.0% in Chinese adults aged 35 to 75 years, and most lesions had a diameter less than 5 mm.
  
  
  BACKGROUND
  National Natural Science Foundation of China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Li
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Chen
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Li
authors.forename: Yuan-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Ying-Sheng
authors.initials: YS
authors.lastname: Cheng
authors.forename: Ding-Jun
authors.initials: DJ
authors.lastname: Hu
authors.forename: Hua-Qiao
authors.initials: HQ
authors.lastname: Tan
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
authors.forename: Zhen-Kui
authors.initials: ZK
authors.lastname: Sun
authors.forename: Xiao-Er
authors.initials: XE
authors.lastname: Wei
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Zhang
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Qiao
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Zong
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Lou
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: De-Rong
authors.initials: DR
authors.lastname: Peng
authors.forename: Sui-Xin
authors.initials: SX
authors.lastname: Ding
authors.forename: Xue-Fan
authors.initials: XF
authors.lastname: Xu
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Hou
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002343:Carotid Artery, Internal / Q000473:pathology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology* / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution