title: Steric control of site selectivity in the Pd-catalyzed C-H acetoxylation of simple arenes.
abstract: This report describes the use of an oxidant and a ligand to control site selectivity in the Pd(OAc)2-catalyzed C-H acetoxylation of simple arenes. The use of MesI(OAc)2 as the terminal oxidant in combination with acridine as the ligand results in primarily sterically controlled selectivity. In contrast, with Pd(OAc)2 as the catalyst and PhI(OAc)2 as the oxidant, electronic effects dominate the selectivity of arene C-H acetoxylation.
authors.affiliation: University of Michigan , Department of Chemistry, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Cook
authors.forename: Marion H
authors.initials: MH
authors.lastname: Emmert
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford