title: L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats.
abstract: Opiate addiction is a chronic, relapsing brain disease characterized by persistent and uncontrolled drug-seeking behavior despite negative effects. L-Stepholidine (L-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of L-SPD suggests that L-SPD may be effective for the treatment of opiate addiction. The aim of this study was to characterize the effects of L-SPD on heroin self-administration on a fixed-ratio 1 schedule and cue-induced reinstatement under an extinction/reinstatement protocol. The effect of L-SPD on the locomotor activity of heroin-free rats was also tested. We found that 2.5, 5, and 10 mg/kg of L-SPD attenuated heroin self-administration and cue-induced reinstatement without affecting locomotor activity. These results showed that L-SPD, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement.
authors.affiliation: aWuhan Institutes of Biomedical Sciences, Jianghan University bDrug Prevention and Education Center, Hubei Public Security Bureau, Wuhan cShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yue
authors.forename: Baomiao
authors.initials: B
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Tian
authors.forename: Qin
authors.initials: Q
authors.lastname: Ru
authors.forename: Yongping
authors.initials: Y
authors.lastname: Gan
authors.forename: Daisong
authors.initials: D
authors.lastname: Wang
authors.forename: Guozhang
authors.initials: G
authors.lastname: Jin
authors.forename: Chaoying
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D003463:Cues; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D005108:Extinction, Psychological / Q000187:drug effects; D003932:Heroin / Q000008:administration & dosage*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009294:Narcotics / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000819:agonists; D012054:Reinforcement, Psychology; D012646:Self Administration
chemical_list: D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D009294:Narcotics; D017447:Receptors, Dopamine D1; D001599:Berberine; C010513:stepholidine; D003932:Heroin