title: [Potential drug interactions in patients with sepsis admitted to the intensive care unit].
abstract: OBJECTIVE
  To analyze, detect and classify potential drug interactions in patients with sepsis admitted to the intensive care unit.
  
  
  METHODS
  This prospective observational cohort study of septic patients was conducted between April 2010 and August 2011. Data collection included demographic characteristics, clinical features, and analysis of pharmacotherapy.
  
  
  RESULTS
  Of 86 patients, 80% had potential drug interactions, with a mean of 1.84 ± 1.09 interaction per patient. Regarding the classification of drug interactions, 64.2% had a pharmacodynamic profile, 60% were of major severity, 53.3% had a rapid onset of action, and 53.8% had good documentation. The prevalence of interactions was associated with age, number of drugs prescribed, and length of stay in the intensive care unit (p < 0.001).
  
  
  CONCLUSIONS
  This study showed that drug interactions represent an important clinical concern in septic patients admitted to intensive care units.
authors.forename: R A
authors.initials: RA
authors.lastname: Caribé
authors.forename: G R
authors.initials: GR
authors.lastname: Chaves
authors.forename: J D
authors.initials: JD
authors.lastname: Pocognoni
authors.forename: I A
authors.initials: IA
authors.lastname: Souza
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D001938:Brazil; D003422:Critical Care; D003428:Cross Infection / Q000188:drug therapy; D004347:Drug Interactions; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D012308:Risk Management; D018805:Sepsis / Q000188:drug therapy*; D011795:Surveys and Questionnaires