title: Value of proBNP1-108 testing for the risk stratification of patients with systolic heart failure.
abstract: The study objectives were to determine the circulating levels of proBNP1-108, the precursor of B-type natriuretic peptide (BNP) and amino-terminal pro-BNP (NT-proBNP), in patients with systolic heart failure (HF) and to assess their prognosis value for cardiovascular (CV) death over a long-term follow-up. Seventy-three patients with systolic HF and 68 healthy volunteers were included. ProBNP1-108, BNP and NT-proBNP levels were measured with automated immunoassays and their predictive value for long-term survival was assessed through an 8 years follow-up. ProBNP1-108 levels were markedly increased in patients with systolic HF in comparison to healthy volunteers. In univariate proportional hazard model, survival was related to proBNP1-108, BNP, NT-proBNP, age, EF and glomerular filtration rate (eGFR). Kaplan-Meier survival curves according to proBNP tertiles diverged significantly, and the highest proBNP levels were related to patients with the highest risk of CV death. In a multivariate analysis including age, EF, proBNP1-108, BNP, NT-proBNP, and eGFR levels, NT-proBNP was the strongest predictor of long term CV death. Our study therefore demonstrated that high levels of proBNP1-108, measured with an assay with enhanced analytical specificity, are related to the long-term risk of cardiovascular death in systolic heart failure.
authors.affiliation: Pôle de Recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium; Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium. Electronic address: damien.gruson@uclouvain.be.
authors.forename: Damien
authors.initials: D
authors.lastname: Gruson
authors.forename: Thibault
authors.initials: T
authors.lastname: Lepoutre
authors.forename: Sylvie A
authors.initials: SA
authors.lastname: Ahn
authors.forename: Michel F
authors.initials: MF
authors.lastname: Rousseau
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D054143:Heart Failure, Systolic / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D013318:Stroke Volume / Q000502:physiology; D016019:Survival Analysis
chemical_list: D010446:Peptide Fragments; C524086:Pro-BNP1-108; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: BNP; Heart failure; NT-proBNP; ProBNP(1–108); Prognosis