title: Mammalian cardiolipin biosynthesis.
abstract: Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis and provide an overview of regulation of cardiolipin biosynthesis. In addition, the important role that this key phospholipid plays in disease processes including heart failure, diabetes, thyroid hormone disease and the genetic disease Barth Syndrome will be discussed.
authors.affiliation: Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
authors.forename: Edgard M
authors.initials: EM
authors.lastname: Mejia
authors.affiliation: Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
authors.forename: Hieu
authors.initials: H
authors.lastname: Nguyen
authors.affiliation: Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada; Department of Biochemistry and Medical Genetics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, DREAM Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada. Electronic address: ghatch@mich.ca.
authors.forename: Grant M
authors.initials: GM
authors.lastname: Hatch
mesh_terms: D000818:Animals; D002308:Cardiolipins / Q000096:biosynthesis* / Q000378:metabolism; D004194:Disease; D006801:Humans; D008322:Mammals / Q000378:metabolism*
chemical_list: D002308:Cardiolipins
keywords: Barth Syndrome; Cardiolipin; Diabetes; Genetic disease; Heart failure; Lipid; Metabolism; Mitochondria; Phospholipid; Thyroid hormone