title: Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion.
abstract: OBJECTIVE
  Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma are aggressive neoplasms with a propensity to involve the meninges and dura. In addition to similar clinical presentations, both meningeal HPC and mesenchymal chondrosarcoma share overlapping morphologic features, including ovoid cells, variable collagen deposition, and a branching vascular pattern. Recently, a novel HEY1-NCOA2 fusion was reported as a recurrent event in mesenchymal chondrosarcomas.
  
  
  METHODS
  Thirteen mesenchymal chondrosarcomas and 18 meningeal HPCs were identified from surgical pathology archives, and the tumors were evaluated for HEY1-NCOA2 fusion with reverse transcriptase-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  HEY1-NCOA2 fusion transcript was detected in all six cases of mesenchymal chondrosarcoma but in none of the meningeal HPC cases (0/11) that were evaluable with RT-PCR.
  
  
  CONCLUSIONS
  These results show that (1) meningeal HPC and mesenchymal chondrosarcoma are distinct at the molecular level, and (2) the identification of HEY1-NCOA2 can be used as an auxiliary diagnostic tool to differentiate these entities.
authors.affiliation: Mayo Clinic, Dept of Anatomic Pathology, Hilton 11, 200 First St, SW, Rochester, MN 55905; fritchie.karen@mayo.edu.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Fritchie
authors.forename: Long
authors.initials: L
authors.lastname: Jin
authors.forename: Ana
authors.initials: A
authors.lastname: Ruano
authors.forename: Andre M
authors.initials: AM
authors.lastname: Oliveira
authors.forename: Brian P
authors.initials: BP
authors.lastname: Rubin
mesh_terms: D000328:Adult; D000368:Aged; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D018211:Chondrosarcoma, Mesenchymal / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D051958:Nuclear Receptor Coactivator 2 / Q000235:genetics* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D004273:DNA, Neoplasm; D051958:Nuclear Receptor Coactivator 2; D015514:Oncogene Proteins, Fusion; C485631:HEY1 protein, human; C498001:NCOA2 protein, human
keywords: HEY1-NCOA2; Meningeal hemangiopericytoma; Mesenchymal chondrosarcoma