title: Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions.
abstract: Systematic exchange of amino acid residues of similar physicochemical properties maintains specific coiled-coil interaction between two heptad repeats of HIV-1 gp41, as well as the biological activity of related peptide fusion inhibitors. This exchangeability can greatly degenerate sequence space of peptides thus making ab initio design of coiled-coil interaction feasible.
authors.affiliation: Department of Medicinal Chemistry, Beijing Institute of Pharmacology & Toxicology, 27 Taiping Rd, Haidian District, Beijing 100850, China. caileefeng@gmail.com keliangliu55@126.com.
authors.forename: Guiying
authors.initials: G
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Baohua
authors.initials: B
authors.lastname: Zheng
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
authors.forename: Yanni
authors.initials: Y
authors.lastname: Li
authors.forename: Keliang
authors.initials: K
authors.lastname: Liu
authors.forename: Lifeng
authors.initials: L
authors.lastname: Cai
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D055598:Chemical Phenomena; D015700:HIV Envelope Protein gp41 / Q000737:chemistry*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D015202:Protein Engineering; D020449:Repetitive Sequences, Amino Acid
chemical_list: D000596:Amino Acids; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; C514787:gp41 protein, Human immunodeficiency virus 1