title: Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample.
abstract: We genotyped the LPR and VNTR polymorphisms of the serotonin transporter gene in 504 cocaine-dependent patients and 508 controls. No association was detected with either polymorphism or with any haplotype combination. This study provided no evidence that these polymorphisms confer susceptibility to cocaine dependence in our sample.
authors.affiliation: Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Tristán-Noguero
authors.forename: Noèlia
authors.initials: N
authors.lastname: Fernàndez-Castillo
authors.forename: Carlos
authors.initials: C
authors.lastname: Roncero
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez-Mora
authors.forename: Josep Antoni
authors.initials: JA
authors.lastname: Ramos-Quiroga
authors.forename: Constanza
authors.initials: C
authors.lastname: Daigre
authors.forename: Angel
authors.initials: A
authors.lastname: Egido
authors.forename: Joan
authors.initials: J
authors.lastname: Alvarós
authors.forename: Gemma
authors.initials: G
authors.lastname: Prat
authors.forename: Miquel
authors.initials: M
authors.lastname: Casas
authors.forename: Bru
authors.initials: B
authors.lastname: Cormand
authors.forename: Marta
authors.initials: M
authors.lastname: Ribasés
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000208:ethnology* / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013030:Spain; D044465:White People / Q000208:ethnology / Q000235:genetics
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5HTT; Association study; Drug addiction