title: Perioperative morbidity associated with abdominal myomectomy compared with total abdominal hysterectomy for uterine fibroids.
abstract: The aim of the study was to systematically review and summarise existing evidence related to the perioperative morbidity associated with abdominal myomectomy in comparison with abdominal hysterectomy for uterine fibroids. A review of MEDLINE and EMBASE was carried out. The primary outcome was the major morbidity rate and secondary outcomes were uterine size, estimated blood loss, blood transfusion, operating time and duration of hospital stay. The results identified six observational studies including 1520 participants. All studies scored moderately on the N-OQA scale and were limited to a uterine size of up to 18 weeks. There was no significant difference in the rate of major morbidity (RR 0.94; 95% CI = 0.31, 2.81; p = 0.91) between the two operations. It was concluded that based on variable quality data from retrospective cohort studies, abdominal myomectomy and hysterectomy appear to have similar major morbidity rates for the uterine size up to 16-18 weeks. Well-designed trials with a standardised morbidity outcome and including uterine size greater than 18 weeks are required.
authors.affiliation: Assisted Conception Unit, Guy's and St. Thomas NHS Trust , London , UK.
authors.forename: J
authors.initials: J
authors.lastname: Pundir
authors.forename: R
authors.initials: R
authors.lastname: Walawalkar
authors.forename: S
authors.initials: S
authors.lastname: Seshadri
authors.forename: Y
authors.initials: Y
authors.lastname: Khalaf
authors.forename: T
authors.initials: T
authors.lastname: El-Toukhy
mesh_terms: D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D007889:Leiomyoma / Q000601:surgery*; D059035:Perioperative Period; D063186:Uterine Myomectomy / Q000009:adverse effects* / Q000706:statistics & numerical data; D014594:Uterine Neoplasms / Q000601:surgery*