title: A study of adaptation mechanisms based on ABR recorded at high stimulation rate.
abstract: OBJECTIVE
  This paper analyzes the fast and slow mechanisms of adaptation through a study of latencies and amplitudes on ABR recorded at high stimulation rates using the randomized stimulation and averaging (RSA) technique.
  
  
  METHODS
  The RSA technique allows a separate processing of auditory responses, and is used, in this study, to categorize responses according to the interstimulus interval (ISI) of their preceding stimulus. The fast and slow mechanisms of adaptation are analyzed by the separated responses methodology, whose underlying principles and mathematical basis are described in detail.
  
  
  RESULTS
  The morphology of the ABR is influenced by both fast and slow mechanisms of adaptation. These results are consistent with previous animal studies based on spike rate.
  
  
  CONCLUSIONS
  Both fast and slow mechanisms of adaptation are present in all subjects. In addition, the distribution of the jitter and the sequencing of the stimuli may be critical parameters when obtaining reliable ABRs.
  
  
  CONCLUSIONS
  The separated responses methodology enables for the first time the analysis of the fast and slow mechanisms of adaptation in ABR obtained at stimulation rates greater than 100 Hz. The non-invasive nature of this methodology is appropriate for its use in humans.
authors.affiliation: Department of Signal Theory, Telematics and Communications, CITIC-UGR, University of Granada, C/ Periodista Daniel Saucedo Aranda s/n, 18071 Granada, Spain; MRC Institute of Hearing Research, Southampton Outstation, Royal South Hants Hospital, Brintons Terrace, Mailpoint OAU, Southampton, Hampshire SO14 OYG, UK. Electronic address: jvalderrama@ugr.es.
authors.forename: Joaquin T
authors.initials: JT
authors.lastname: Valderrama
authors.affiliation: Department of Signal Theory, Telematics and Communications, CITIC-UGR, University of Granada, C/ Periodista Daniel Saucedo Aranda s/n, 18071 Granada, Spain. Electronic address: atv@ugr.es.
authors.forename: Angel
authors.initials: A
authors.lastname: de la Torre
authors.affiliation: Department of Signal Theory, Telematics and Communications, CITIC-UGR, University of Granada, C/ Periodista Daniel Saucedo Aranda s/n, 18071 Granada, Spain. Electronic address: isamaru@ugr.es.
authors.forename: Isaac
authors.initials: I
authors.lastname: Alvarez
authors.affiliation: Department of Signal Theory, Telematics and Communications, CITIC-UGR, University of Granada, C/ Periodista Daniel Saucedo Aranda s/n, 18071 Granada, Spain. Electronic address: segura@ugr.es.
authors.forename: Jose Carlos
authors.initials: JC
authors.lastname: Segura
authors.affiliation: MRC Institute of Hearing Research, Southampton Outstation, Royal South Hants Hospital, Brintons Terrace, Mailpoint OAU, Southampton, Hampshire SO14 OYG, UK. Electronic address: ardt@soton.ac.uk.
authors.forename: A Roger D
authors.initials: ARD
authors.lastname: Thornton
authors.affiliation: ENT Service, San Cecilio University Hospital, Av. Dr. Oloriz 16, 18002 Granada, Spain; Department of Surgery and its Specialties, University of Granada, Av. De Madrid 11, 18012 Granada, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sainz
authors.affiliation: ENT Service, San Cecilio University Hospital, Av. Dr. Oloriz 16, 18002 Granada, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Vargas
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D001309:Auditory Threshold / Q000502:physiology*; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology
keywords: Adaptation; Auditory Brainstem Response (ABR); Evoked potentials; Interstimulus interval (ISI); Randomized stimulation and averaging (RSA)