title: Electrochemical serotonin monitoring of poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate)-modified fluorine-doped tin oxide by predeposition of self-assembled 4-pyridylporphyrin.
abstract: A 5,10,15,20-tetrakis(4-pyridyl)-21H,23H-porphyrin (TPyP)-modified self-assembled functional layer was prepared on a fluorine-doped tin oxide (FTO) substrate. We employed a bifunctional molecule, 3-iodopropionate (3IP), to covalently bind TPyP to the FTO substrate. The 3IP-monolayered FTO and the TPyP-3IP-bilayered FTO electrodes were characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and Fourier transform-infrared spectroscopy. Compared to conventional electropolymerized poly(ethylenedioxythiophene):poly(sodium 4-styrenesulfonate) (PEDOT:PSS) film on bare FTO, the PEDOT:PSS film on the TPyP-3IP-bilayered FTO showed better sensitivity and selectivity in monitoring serotonin in the presence of high concentrations of interfering agents such as ascorbic acid, urea, D-(+)-glucose, epinephrine, and L-3,4-dihydroxyphenylalanine. Both PEDOT:PSS films on the bare FTO and the TPyP-3IP-bilayered FTO showed electrocatalytic effects in serotonin detection, and only the TPyP-3IP-based PEDOT:PSS film acted as a pH resistant buffer layer in the selective detection of serotonin.
authors.affiliation: Department of Materials Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Song
authors.forename: Sangsig
authors.initials: S
authors.lastname: Kim
authors.forename: Nam
authors.initials: N
authors.lastname: Ki Min
authors.forename: Joon-Hyung
authors.initials: JH
authors.lastname: Jin
mesh_terms: D015374:Biosensing Techniques; D005461:Fluorine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011137:Polystyrenes / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D012701:Serotonin / Q000302:isolation & purification*; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D011137:Polystyrenes; D011166:Porphyrins; D017971:Tin Compounds; D005461:Fluorine; D012701:Serotonin; C045358:stannic oxide
keywords: 5,10,15,20-tetrakis(4-pyridyl)-21H23H-porphyrin; Binary self-assembled monolayer; Cyclic voltammetry; Electrochemical impedance spectroscopy; PEDOT:PSS; Serotonin