title: Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis.
abstract: Antibiotic abundance: Several new uridyl peptide antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC-ESI-MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N-acetyltransferase, to be responsible for acetylation of the uridyl peptide antibiotic.
authors.affiliation: Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tübingen (Germany).
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Tang
authors.forename: Marcel
authors.initials: M
authors.lastname: Gross
authors.forename: Yunying
authors.initials: Y
authors.lastname: Xie
authors.forename: Andreas
authors.initials: A
authors.lastname: Kulik
authors.forename: Bertolt
authors.initials: B
authors.lastname: Gust
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D008968:Molecular Conformation; D005810:Multigene Family; D009705:Nucleosides / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics / Q000378:metabolism
chemical_list: D009705:Nucleosides; C083650:mureidomycin F; D000123:Acetyltransferases
keywords: N-acetylation; biosynthesis; heterologous expression; uridyl peptide antibiotics