title: Fluorescent conjugate of sLe(x)-selective bisboronic acid for imaging application.
abstract: Carbohydrate-based biomarkers such as sialyl Lewis X are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed a boronolectin-fluorophore conjugate, which was able to selectively label and image xenograft (sc) tumor. This represents the very first example that a small molecule capable of recognizing a carbohydrate biomarker was used for optical imaging application.
authors.affiliation: Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chu
authors.forename: Danzhu
authors.initials: D
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Zhiren Luis
authors.initials: ZL
authors.lastname: Liu
authors.forename: Brent
authors.initials: B
authors.lastname: Weston
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D056945:Hep G2 Cells; D064593:Heterografts; D006801:Humans; D016256:Lewis X Antigen / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D009005:Monosaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D061848:Optical Imaging / Q000379:methods*; D000080506:Sialyl Lewis X Antigen
chemical_list: D001896:Boron Compounds; D005456:Fluorescent Dyes; D016256:Lewis X Antigen; D009005:Monosaccharides; D000080506:Sialyl Lewis X Antigen; C541244:boronolectin
keywords: Biomarker; Boronolectin; Optical imaging; Xenograft tumer