title: Predictive value of selected biomarkers, polymorphisms, and clinical features for oligoarticular juvenile idiopathic arthritis-associated uveitis.
abstract: OBJECTIVE
  Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and is associated with considerable morbidity. The aim of this study was to examine the risk factors associated with uveitis in oligoarticular JIA.
  
  
  METHODS
  We conducted a chart review of 86 patients with oligoarticular JIA to assess if antinuclear antibody (ANA) status, gender, and age at JIA onset were associated with the development of uveitis. Biomarkers such as cytokine gene polymorphisms, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were also assessed.
  
  
  RESULTS
  Twenty-seven patients exhibited oligoarticular JIA-associated uveitis. Only the ESR at arthritis onset and the patient's age at arthritis onset were related to uveitis development in our patient sample.
  
  
  CONCLUSIONS
  An age-associated risk of uveitis was observed in children younger than 3 years at the time of JIA onset. ESR values at arthritis onset higher than 22 mm/h were also related to uveitis development.
authors.affiliation: Instituto Clínic de Oftalmologia, Hospital Clínico , Barcelona , Spain .
authors.forename: Laura
authors.initials: L
authors.lastname: Pelegrín
authors.forename: Ricardo
authors.initials: R
authors.lastname: Casaroli-Marano
authors.forename: Jordi
authors.initials: J
authors.lastname: Antón
authors.forename: María Carmen
authors.initials: MC
authors.lastname: García de Vicuña
authors.forename: Nicolás
authors.initials: N
authors.lastname: Molina-Prat
authors.forename: Juan
authors.initials: J
authors.lastname: Ignacio Aróstegui
authors.forename: Jordi
authors.initials: J
authors.lastname: Yagüe
authors.forename: José
authors.initials: J
authors.lastname: Ríos
authors.forename: Alfredo
authors.initials: A
authors.lastname: Adán
mesh_terms: D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000097:blood*; D001171:Arthritis, Juvenile / Q000097:blood* / Q000150:complications / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014605:Uveitis / Q000097:blood / Q000453:epidemiology / Q000235:genetics*
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; D016207:Cytokines; D002097:C-Reactive Protein; D004247:DNA
keywords: Age of arthritis onset; chronic anterior uveitis; erythrocyte sedimentation rate; oligoarticular juvenile idiopathic arthritis; polymorphism