title: Perspectives on RAGE signaling and its role in cardiovascular disease.
abstract: RAGE stands for Receptor of Advanced Glycation Endproducts. The two main topics discussed are (1) the nature of RAGE signaling and (2) its role in cardiovascular disease. RAGE may occur in membrane-bound form or in secretory form. RAGE signaling involves multiple ligands: (1) several AGEs (2) amyloid β pecursor protein (APP), (3) high mobility group box 1 (HMGB1), (4) S100A4, (5) S100A8/A9, and (6) S100A12, which are calcium-binding proteins, and (7) S100B, a glial-derived protein. RAGE ligands and various diseases involving RAGE signaling are summarized in tabular form.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: M Michael
authors.initials: MM
authors.lastname: Cohen
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products
keywords: AGEs; Alzheimer disease; HMGB1; RAGE signaling; cancer; cardiovascular disease; diabetes mellitus; inflammation; ischemia-reperfusion injury to the heart; membrane-bound RAGE; renal disease; secretory RAGE