title: Asthma and hemoglobinopathy: when is supplemental oxygen required?
abstract: Asthma is the most common reason for referral to the emergency department in childhood. In severe attacks, supplemental O2 is given when oxygen saturation level is <90%. Described herein is the case of a child with persistent low oxygen saturation as measured on pulse oximetry (S(p)O2) after full clinical recovery from an asthma attack. Simultaneously, P(a)O2 was normal. A diagnosis of abnormal hemoglobin with decreased oxygen affinity (hemoglobin Seattle) was made on hemoglobin electrophoresis and genetic analysis. To ascertain when supplemental oxygen was needed, an oxygen dissociation curve was plotted using the tonometer technique, and it was found that an S(p)O2 of 70% is parallel to a P(a)O2 of 60 mmHg. Plotting an oxygen dissociation curve is a simple reproducible method to determine when supplemental oxygen is required for a child with a hemoglobinopathy.
authors.affiliation: Pediatric Pulmonary Unit, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, Midreshet Ben-Gurion, Israel.
authors.forename: Leon
authors.initials: L
authors.lastname: Joseph
authors.forename: Inbal
authors.initials: I
authors.lastname: Brickner-Braun
authors.forename: Berry
authors.initials: B
authors.lastname: Pinshow
authors.forename: Shmuel
authors.initials: S
authors.lastname: Goldberg
authors.forename: Hagit
authors.initials: H
authors.lastname: Miskin
authors.forename: Elie
authors.initials: E
authors.lastname: Picard
mesh_terms: D001249:Asthma / Q000097:blood / Q000150:complications* / Q000628:therapy; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006453:Hemoglobinopathies / Q000097:blood / Q000209:etiology / Q000628:therapy*; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy / Q000379:methods*
chemical_list: D006455:Hemoglobins, Abnormal; C089520:hemoglobin Seattle; D010100:Oxygen
keywords: hemoglobin Seattle; hemoglobinopathy; oxygen saturation