title: Hydrothermal fabrication of ZSM-5 zeolites: biocompatibility, drug delivery property, and bactericidal property.
abstract: The bone graft-associated infection is widely considered in orthopedic surgery, which may lead to implant failure, extensive bone debridement, and increased patient morbidity. In this study, we fabricated ZSM-5 zeolites for drug delivery systems by hydrothermal method. The structure, morphology, biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites were investigated. The ZSM-5 zeolites have mordenite framework inverted-type structure and exhibit the disk-like shape with the diameter of ∼350 nm and thickness of ∼165 nm. The biocompatibility tests indicate that human bone marrow stromal cells spread out well on the surfaces of the ZSM-5 zeolites and proliferate significantly with increasing culture time. As compared with the conventional hydroxyapatite particles, the ZSM-5 zeolites possess greater drug loading efficiency and drug sustained release property because of the ordered micropores, large Brunauer-Emmett-Teller (BET) surface areas, and functional groups. For the gentamicin-loaded ZSM-5 zeolites, the sustained release of gentamicin minimizes significantly bacterial adhesion and prevents biofilm formation against Staphylococcus epidermidis. The excellent biocompatibility, drug delivery property, and bactericidal property of the ZSM-5 zeolites suggest that they have great application potentials for treating implant-associated infections.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Guo
authors.forename: Teng
authors.initials: T
authors.lastname: Long
authors.forename: Zhen-Fu
authors.initials: ZF
authors.lastname: Song
authors.forename: Zhen-An
authors.initials: ZA
authors.lastname: Zhu
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D018441:Biofilms / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D049109:Cell Proliferation; D016503:Drug Delivery Systems; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D017154:Stromal Cells / Q000187:drug effects / Q000648:ultrastructure; D014961:X-Ray Diffraction; D017641:Zeolites / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005839:Gentamicins; C570564:ZSM-5 zeolite; D017641:Zeolites
keywords: ZSM-5 zeolite; bactericidal property; biocompatibility; drug delivery system