title: Long term recovery of median nerve repair using laser-activated chitosan adhesive films.
abstract: Sutures remain the standard peripheral nerve repair technique, whether applied directly or indirectly to nerve tissue. Unfortunately, significant postoperative complications can result, such as inflammation, neuroma formation and foreign body reactions. Photochemical-tissue-bonding (PTB) using rose Bengal (RB) integrated into a chitosan bioadhesive is an alternative nerve repair device that removes the need for sutures. Rats were arranged into three groups: RB-chitosan adhesives-repair, end-to-end epineural suture-repair (surgical standard) and sham laser-irradiated control. Groups were compared through histological assessment, electrophysiological recordings and grip motor strength. RB-chitosan adhesive repaired nerves displayed comparable results when compared to the standard suture-repair based on histological and electrophysiological findings. Functionally, RB-chitosan adhesive was associated with a quicker and more pronounced recovery of grip force when compared to the suture-repair.
authors.affiliation: School of Medicine, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Barton
authors.forename: John W
authors.initials: JW
authors.lastname: Morley
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Stoodley
authors.forename: Sumaiya
authors.initials: S
authors.lastname: Shaikh
authors.forename: David A
authors.initials: DA
authors.lastname: Mahns
authors.forename: Antonio
authors.initials: A
authors.lastname: Lauto
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000269:Adhesives / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D018737:Hand Strength / Q000502:physiology; D007834:Lasers; D008475:Median Nerve / Q000187:drug effects* / Q000293:injuries / Q000502:physiology* / Q000528:radiation effects; D011184:Postoperative Period; D051381:Rats; D020127:Recovery of Function / Q000187:drug effects*; D012395:Rose Bengal / Q000737:chemistry; D013997:Time Factors
chemical_list: D000269:Adhesives; D001672:Biocompatible Materials; D012395:Rose Bengal; D048271:Chitosan
keywords: biomaterial; chitosan; laser; peripheral-nerve-repair; photochemical-tissue-bonding and rose-bengal