title: Prospects of using benzodiazepines in complex therapy of poisonings with anticholinesterase agents.
abstract: The efficiency of benzodiazepines on mouse model of anticholinesterase poisoning was shown. The protective effects of clonazepam and midazolam were observed at high (1 TD50, incoordination) and medium (0.3 TD50) doses and the effects of phenazepam and diazepam were found only at high doses. Midazolam produced the most pronounced protective effect: administration of this drug significantly increased the protective index of atropine+HI-6 combination during poisoning.
authors.affiliation: Research Testing Institute of Military Medicine of S. M. Kirov Military Medical Academy, St. Petersburg, Russia. mihei_bridge@mail.ru.
authors.forename: M A
authors.initials: MA
authors.lastname: Yudin
authors.forename: S N
authors.initials: SN
authors.lastname: Subbotina
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: S V
authors.initials: SV
authors.lastname: Chepur
authors.forename: A S
authors.initials: AS
authors.lastname: Nikiforov
mesh_terms: D000818:Animals; D001285:Atropine; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000506:poisoning*; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D008297:Male; D051379:Mice; D008874:Midazolam / Q000494:pharmacology; D010091:Oximes; D011726:Pyridinium Compounds; D018709:Statistics, Nonparametric; D018675:Toxicity Tests
chemical_list: D002800:Cholinesterase Inhibitors; D010091:Oximes; D011726:Pyridinium Compounds; D001569:Benzodiazepines; C017928:phenazepam; D002998:Clonazepam; D001285:Atropine; C022870:asoxime chloride; D003975:Diazepam; D008874:Midazolam