title: Enhanced osteoconductivity of titanium implant by polarization-induced surface charges.
abstract: This study introduces the application of method for electrically polarizing titanium implants coated with anatase TiO2 using microarc oxidation. It also describes the features of the electrically polarized titanium implants, on which surface charges are generated by the dipole moment of the TiO2 , and describes how the surface charges affect the implants' in vivo bone-implant integration capability. A comprehensive assessment using biomechanical, histomorphological, and radiographic analyses in a rabbit model was performed on polarized and nonpolarized implants. The electrically polarized surfaces accelerated the establishment of implant biomechanical fixation, compared with the nonpolarized surfaces. The percentage of the bone-implant contact ratio was higher using polarized implants than using nonpolarized implants. In contrast, the bone volume around the implants was not affected by polarization. Thus, using the polarized implant, this study identified that controlled surface charges have a significant effect on the properties of titanium implants. The application of the electrical polarization process and the polarization-enhanced osteoinductivity, which resulted in greater bone-implant integration, was clearly demonstrated.
authors.affiliation: Department of Material Biofunctions, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nozaki
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Naohiro
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Miho
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takakuda
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Yamashita
authors.forename: Akiko
authors.initials: A
authors.lastname: Nagai
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D008297:Male; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D055672:Static Electricity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; C009495:titanium dioxide; D014025:Titanium
keywords: dental implant; electrical polarization; micro-CT analysis; osseointegration; surface modification