title: Of mice and men: what physiological correlates of cognitive deficits in a mouse model of schizophrenia tell us about psychiatric disease.
abstract: Hippocampal neurons "replay" activity related to previous events during rest. In this issue of Neuron, Suh et al. (2013) show that this physiological correlate of learning is impaired in mice lacking calcineurin, establishing a link between synaptic anomalies and cognitive deficits observed in this schizophrenia model.
authors.affiliation: Neuroscience Research Unit, Pfizer, Cambridge, MA 02139, USA. Electronic address: patricio.o'donnell@pfizer.com.
authors.forename: Patricio
authors.initials: P
authors.lastname: O'Donnell
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000502:physiology*; D056547:CA1 Region, Hippocampal / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology*; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology